Stem definition | Drug id | CAS RN |
---|---|---|
vinca alkaloids | 2823 | 865-21-4 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 10 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
BA (Bioavailability) | 0 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 28 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 3.10 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.14 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 67 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 5, 1965 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neutropenia | 190.38 | 27.27 | 138 | 4963 | 158029 | 56128937 |
Febrile neutropenia | 169.23 | 27.27 | 110 | 4991 | 105435 | 56181531 |
Pulmonary toxicity | 102.04 | 27.27 | 35 | 5066 | 7848 | 56279118 |
Pancytopenia | 87.74 | 27.27 | 69 | 5032 | 88646 | 56198320 |
Malignant neoplasm progression | 70.08 | 27.27 | 56 | 5045 | 73531 | 56213435 |
Second primary malignancy | 69.83 | 27.27 | 26 | 5075 | 7376 | 56279590 |
Tissue infiltration | 68.77 | 27.27 | 15 | 5086 | 610 | 56286356 |
Basal ganglion degeneration | 67.86 | 27.27 | 14 | 5087 | 434 | 56286532 |
Disease progression | 63.91 | 27.27 | 62 | 5039 | 105111 | 56181855 |
Uterine enlargement | 59.25 | 27.27 | 15 | 5086 | 1168 | 56285798 |
Product use in unapproved indication | 55.50 | 27.27 | 66 | 5035 | 140756 | 56146210 |
Inguinal hernia | 53.08 | 27.27 | 15 | 5086 | 1776 | 56285190 |
Anaesthesia | 51.67 | 27.27 | 11 | 5090 | 398 | 56286568 |
Febrile bone marrow aplasia | 50.91 | 27.27 | 20 | 5081 | 6552 | 56280414 |
Myelodysplastic syndrome | 49.95 | 27.27 | 26 | 5075 | 16380 | 56270586 |
Psychogenic seizure | 49.73 | 27.27 | 14 | 5087 | 1635 | 56285331 |
Interstitial lung disease | 49.19 | 27.27 | 41 | 5060 | 57022 | 56229944 |
Pleuroparenchymal fibroelastosis | 47.32 | 27.27 | 7 | 5094 | 26 | 56286940 |
Toxic neuropathy | 46.71 | 27.27 | 10 | 5091 | 372 | 56286594 |
Refractory anaemia with an excess of blasts | 45.43 | 27.27 | 10 | 5091 | 424 | 56286542 |
Dysaesthesia | 44.54 | 27.27 | 16 | 5085 | 4100 | 56282866 |
Neurological decompensation | 44.24 | 27.27 | 14 | 5087 | 2440 | 56284526 |
Hypochromic anaemia | 43.83 | 27.27 | 13 | 5088 | 1825 | 56285141 |
Ileus | 42.26 | 27.27 | 22 | 5079 | 13860 | 56273106 |
Astrocytoma, low grade | 41.86 | 27.27 | 7 | 5094 | 65 | 56286901 |
Monoplegia | 41.59 | 27.27 | 14 | 5087 | 2960 | 56284006 |
Hyperpyrexia | 40.30 | 27.27 | 14 | 5087 | 3254 | 56283712 |
Premature menopause | 39.25 | 27.27 | 10 | 5091 | 798 | 56286168 |
Pyrexia | 39.23 | 27.27 | 104 | 4997 | 418669 | 55868297 |
Congestive cardiomyopathy | 39.15 | 27.27 | 16 | 5085 | 5803 | 56281163 |
Premature baby | 38.16 | 27.27 | 23 | 5078 | 19182 | 56267784 |
Acute myeloid leukaemia | 35.47 | 27.27 | 21 | 5080 | 16951 | 56270015 |
Off label use | 34.98 | 27.27 | 120 | 4981 | 556060 | 55730906 |
Pneumocystis jirovecii pneumonia | 34.32 | 27.27 | 20 | 5081 | 15681 | 56271285 |
Lymphadenopathy | 33.91 | 27.27 | 27 | 5074 | 35181 | 56251785 |
Foetal exposure during pregnancy | 32.71 | 27.27 | 26 | 5075 | 33797 | 56253169 |
Intervertebral disc disorder | 32.36 | 27.27 | 13 | 5088 | 4513 | 56282453 |
Klebsiella infection | 31.63 | 27.27 | 15 | 5086 | 7741 | 56279225 |
Mucosal inflammation | 31.28 | 27.27 | 28 | 5073 | 42782 | 56244184 |
Splenomegaly | 30.62 | 27.27 | 16 | 5085 | 10152 | 56276814 |
Pericarditis constrictive | 30.60 | 27.27 | 7 | 5094 | 354 | 56286612 |
Meningitis streptococcal | 30.40 | 27.27 | 6 | 5095 | 148 | 56286818 |
Pseudohyponatraemia | 30.35 | 27.27 | 5 | 5096 | 42 | 56286924 |
Lung disorder | 30.02 | 27.27 | 30 | 5071 | 52567 | 56234399 |
Renal cyst | 29.04 | 27.27 | 15 | 5086 | 9294 | 56277672 |
Abdominal tenderness | 28.84 | 27.27 | 14 | 5087 | 7607 | 56279359 |
Respiratory failure | 28.60 | 27.27 | 39 | 5062 | 95023 | 56191943 |
Hypothyroidism | 27.94 | 27.27 | 25 | 5076 | 38171 | 56248795 |
Neuropathy peripheral | 27.67 | 27.27 | 40 | 5061 | 102853 | 56184113 |
Leukaemia | 27.53 | 27.27 | 11 | 5090 | 3764 | 56283202 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 228.32 | 25.98 | 180 | 5342 | 121669 | 31570153 |
Second primary malignancy | 186.80 | 25.98 | 63 | 5459 | 6969 | 31684853 |
Neutropenia | 126.44 | 25.98 | 138 | 5384 | 140226 | 31551596 |
Acute myeloid leukaemia | 121.37 | 25.98 | 61 | 5461 | 18611 | 31673211 |
Cardiotoxicity | 95.06 | 25.98 | 35 | 5487 | 4992 | 31686830 |
Product use in unapproved indication | 81.34 | 25.98 | 93 | 5429 | 99078 | 31592744 |
Azoospermia | 76.33 | 25.98 | 17 | 5505 | 388 | 31691434 |
Off label use | 71.51 | 25.98 | 174 | 5348 | 347100 | 31344722 |
Endocarditis noninfective | 69.72 | 25.98 | 13 | 5509 | 116 | 31691706 |
Pulmonary toxicity | 68.14 | 25.98 | 28 | 5494 | 5349 | 31686473 |
Neutrophil count decreased | 66.60 | 25.98 | 59 | 5463 | 46335 | 31645487 |
Malignant neoplasm progression | 61.21 | 25.98 | 72 | 5450 | 78926 | 31612896 |
Chronic myeloid leukaemia | 58.82 | 25.98 | 21 | 5501 | 2740 | 31689082 |
Cytomegalovirus chorioretinitis | 54.40 | 25.98 | 21 | 5501 | 3407 | 31688415 |
Testicular disorder | 53.94 | 25.98 | 14 | 5508 | 619 | 31691203 |
Myositis | 51.54 | 25.98 | 29 | 5493 | 11065 | 31680757 |
Pneumocystis jirovecii pneumonia | 49.83 | 25.98 | 34 | 5488 | 18217 | 31673605 |
Autoimmune neutropenia | 48.82 | 25.98 | 11 | 5511 | 265 | 31691557 |
Interstitial lung disease | 45.93 | 25.98 | 55 | 5467 | 61348 | 31630474 |
Myelodysplastic syndrome | 45.89 | 25.98 | 33 | 5489 | 19218 | 31672604 |
Bone marrow failure | 40.91 | 25.98 | 36 | 5486 | 27972 | 31663850 |
Cytopenia | 38.60 | 25.98 | 24 | 5498 | 10986 | 31680836 |
Desmoid tumour | 38.38 | 25.98 | 8 | 5514 | 132 | 31691690 |
Polyneuropathy | 34.93 | 25.98 | 24 | 5498 | 12998 | 31678824 |
Cardiac dysfunction | 34.50 | 25.98 | 13 | 5509 | 1974 | 31689848 |
Pneumonia salmonella | 32.65 | 25.98 | 6 | 5516 | 49 | 31691773 |
Optic glioma | 32.54 | 25.98 | 6 | 5516 | 50 | 31691772 |
Myelosuppression | 31.99 | 25.98 | 24 | 5498 | 14896 | 31676926 |
Pulmonary fibrosis | 31.78 | 25.98 | 25 | 5497 | 16635 | 31675187 |
Cryptococcal fungaemia | 28.90 | 25.98 | 6 | 5516 | 97 | 31691725 |
Ichthyosis | 28.72 | 25.98 | 6 | 5516 | 100 | 31691722 |
Treatment failure | 27.98 | 25.98 | 35 | 5487 | 40757 | 31651065 |
Spindle cell sarcoma | 27.10 | 25.98 | 6 | 5516 | 133 | 31691689 |
Neuropathy peripheral | 26.05 | 25.98 | 47 | 5475 | 75602 | 31616220 |
Pancytopenia | 26.03 | 25.98 | 51 | 5471 | 87265 | 31604557 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 343.38 | 22.99 | 256 | 9374 | 204062 | 70714752 |
Neutropenia | 277.50 | 22.99 | 249 | 9381 | 256907 | 70661907 |
Second primary malignancy | 253.91 | 22.99 | 87 | 9543 | 12964 | 70905850 |
Pulmonary toxicity | 171.82 | 22.99 | 62 | 9568 | 10736 | 70908078 |
Acute myeloid leukaemia | 160.24 | 22.99 | 80 | 9550 | 30860 | 70887954 |
Malignant neoplasm progression | 136.97 | 22.99 | 121 | 9509 | 121618 | 70797196 |
Product use in unapproved indication | 131.49 | 22.99 | 151 | 9479 | 207327 | 70711487 |
Pancytopenia | 90.63 | 22.99 | 107 | 9523 | 151000 | 70767814 |
Myelodysplastic syndrome | 90.13 | 22.99 | 54 | 9576 | 29731 | 70889083 |
Disease progression | 87.51 | 22.99 | 107 | 9523 | 156565 | 70762249 |
Interstitial lung disease | 86.94 | 22.99 | 88 | 9542 | 104597 | 70814217 |
Cardiotoxicity | 83.10 | 22.99 | 37 | 9593 | 11033 | 70907781 |
Neutrophil count decreased | 82.03 | 22.99 | 77 | 9553 | 83479 | 70835335 |
Chronic myeloid leukaemia | 81.63 | 22.99 | 28 | 9602 | 4173 | 70914641 |
Off label use | 80.78 | 22.99 | 252 | 9378 | 742808 | 70176006 |
Pneumocystis jirovecii pneumonia | 79.44 | 22.99 | 50 | 9580 | 30032 | 70888782 |
Endocarditis noninfective | 67.00 | 22.99 | 13 | 9617 | 191 | 70918623 |
Pleuroparenchymal fibroelastosis | 66.00 | 22.99 | 11 | 9619 | 63 | 70918751 |
Myelitis | 63.72 | 22.99 | 20 | 9610 | 2257 | 70916557 |
Cytopenia | 59.22 | 22.99 | 34 | 9596 | 17289 | 70901525 |
Pyrexia | 56.03 | 22.99 | 195 | 9435 | 606757 | 70312057 |
Myelosuppression | 55.35 | 22.99 | 40 | 9590 | 30105 | 70888709 |
Tissue infiltration | 51.73 | 22.99 | 13 | 9617 | 651 | 70918163 |
Basal ganglion degeneration | 51.48 | 22.99 | 12 | 9618 | 436 | 70918378 |
Lung disorder | 49.75 | 22.99 | 54 | 9576 | 69430 | 70849384 |
Desmoid tumour | 48.83 | 22.99 | 10 | 9620 | 196 | 70918618 |
Neuropathy peripheral | 48.35 | 22.99 | 72 | 9558 | 126824 | 70791990 |
Uterine enlargement | 47.99 | 22.99 | 13 | 9617 | 874 | 70917940 |
Astrocytoma, low grade | 46.15 | 22.99 | 9 | 9621 | 136 | 70918678 |
Myositis | 45.98 | 22.99 | 29 | 9601 | 17460 | 70901354 |
Cytomegalovirus chorioretinitis | 43.94 | 22.99 | 19 | 9611 | 5279 | 70913535 |
Mucosal inflammation | 43.87 | 22.99 | 50 | 9580 | 67800 | 70851014 |
Optic glioma | 43.71 | 22.99 | 8 | 9622 | 84 | 70918730 |
Congestive cardiomyopathy | 41.55 | 22.99 | 23 | 9607 | 10903 | 70907911 |
Autoimmune neutropenia | 40.36 | 22.99 | 10 | 9620 | 472 | 70918342 |
Astrocytoma | 40.31 | 22.99 | 9 | 9621 | 269 | 70918545 |
Anaesthesia | 40.28 | 22.99 | 10 | 9620 | 476 | 70918338 |
Psychogenic seizure | 38.25 | 22.99 | 13 | 9617 | 1883 | 70916931 |
Ileus | 35.27 | 22.99 | 28 | 9602 | 24209 | 70894605 |
Bone marrow failure | 34.92 | 22.99 | 38 | 9592 | 48972 | 70869842 |
Toxic neuropathy | 34.42 | 22.99 | 10 | 9620 | 868 | 70917946 |
Thrombocytopenia | 34.41 | 22.99 | 90 | 9540 | 239020 | 70679794 |
Refractory anaemia with an excess of blasts | 34.20 | 22.99 | 10 | 9620 | 888 | 70917926 |
Dysaesthesia | 34.16 | 22.99 | 16 | 9614 | 5352 | 70913462 |
Polyneuropathy | 33.90 | 22.99 | 26 | 9604 | 21389 | 70897425 |
Neoplasm progression | 33.86 | 22.99 | 36 | 9594 | 45192 | 70873622 |
Pneumonia salmonella | 33.14 | 22.99 | 6 | 9624 | 59 | 70918755 |
Febrile bone marrow aplasia | 31.81 | 22.99 | 20 | 9610 | 11971 | 70906843 |
Hypothyroidism | 31.77 | 22.99 | 35 | 9595 | 45720 | 70873094 |
Pulmonary fibrosis | 30.57 | 22.99 | 30 | 9600 | 34280 | 70884534 |
Monoplegia | 30.04 | 22.99 | 13 | 9617 | 3618 | 70915196 |
Ichthyosis | 28.42 | 22.99 | 6 | 9624 | 137 | 70918677 |
Guillain-Barre syndrome | 28.06 | 22.99 | 16 | 9614 | 8024 | 70910790 |
Hypochromic anaemia | 27.49 | 22.99 | 11 | 9619 | 2516 | 70916298 |
Cryptococcal fungaemia | 27.15 | 22.99 | 6 | 9624 | 171 | 70918643 |
Treatment failure | 26.88 | 22.99 | 60 | 9570 | 144082 | 70774732 |
Ileus paralytic | 26.79 | 22.99 | 16 | 9614 | 8745 | 70910069 |
Peripheral sensory neuropathy | 26.73 | 22.99 | 18 | 9612 | 12092 | 70906722 |
Neurological decompensation | 26.68 | 22.99 | 13 | 9617 | 4743 | 70914071 |
Lymphadenopathy | 26.65 | 22.99 | 33 | 9597 | 48758 | 70870056 |
Spindle cell sarcoma | 25.45 | 22.99 | 6 | 9624 | 229 | 70918585 |
Pneumonitis | 25.24 | 22.99 | 34 | 9596 | 54563 | 70864251 |
Respiratory failure | 24.75 | 22.99 | 64 | 9566 | 168671 | 70750143 |
Oropharyngeal squamous cell carcinoma | 24.74 | 22.99 | 6 | 9624 | 259 | 70918555 |
Left ventricular dysfunction | 24.55 | 22.99 | 20 | 9610 | 17937 | 70900877 |
Inguinal hernia | 24.15 | 22.99 | 13 | 9617 | 5832 | 70912982 |
Intervertebral disc disorder | 24.14 | 22.99 | 12 | 9618 | 4573 | 70914241 |
Splenic infection fungal | 23.99 | 22.99 | 5 | 9625 | 107 | 70918707 |
Pseudohyponatraemia | 22.99 | 22.99 | 5 | 9625 | 132 | 70918682 |
None
Source | Code | Description |
---|---|---|
ATC | L01CA01 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS Vinca alkaloids and analogues |
FDA CS | M0022674 | Vinca Alkaloids |
FDA EPC | N0000175612 | Vinca Alkaloid |
MeSH PA | D050256 | Antimitotic Agents |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D000972 | Antineoplastic Agents, Phytogenic |
MeSH PA | D050257 | Tubulin Modulators |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:35705 | immunosuppressive agents |
CHEBI has role | CHEBI:61951 | microtubule destabilizing role |
CHEBI has role | CHEBI:76924 | plant metabolites |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Kaposi's sarcoma | indication | 109385007 | |
Hodgkin's disease | indication | 118599009 | |
Non-Hodgkin's lymphoma | indication | 118601006 | |
Langerhans cell histiocytosis, disseminated | indication | 118614007 | |
Mycosis fungoides | indication | 118618005 | |
Malignant tumor of testis | indication | 363449006 | DOID:2998 |
Carcinoma of female breast | indication | 447782002 | |
Gestational trophoblastic neoplasia | indication | 609519004 | DOID:3590 |
Metastatic Breast Carcinoma | indication | ||
Non-small cell lung cancer | off-label use | 254637007 | DOID:3908 |
Malignant tumor of head and/or neck | off-label use | 255056009 | |
Malignant tumor of urinary bladder | off-label use | 399326009 | DOID:11054 |
Neuroblastoma | off-label use | 432328008 | DOID:769 |
Ovarian Germ Cell Tumor Carcinoma | off-label use | ||
Mycosis | contraindication | 3218000 | DOID:1564 |
Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
Disorder of lung | contraindication | 19829001 | DOID:850 |
Viral disease | contraindication | 34014006 | DOID:934 |
Depressive disorder | contraindication | 35489007 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Hepatic failure | contraindication | 59927004 | |
Bacterial infectious disease | contraindication | 87628006 | |
Impaired wound healing | contraindication | 271618001 | |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Peripheral nerve disease | contraindication | 302226006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Protozoal Infection | contraindication | ||
Severe Leukopenia | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 11.32 | acidic |
pKa2 | 13.81 | acidic |
pKa3 | 7.54 | Basic |
pKa4 | 6.84 | Basic |
pKa5 | 6.11 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Tubulin beta | Tumour-associated antigen | INHIBITOR | IC50 | 9 | IUPHAR | SCIENTIFIC LITERATURE | |||
Canalicular multispecific organic anion transporter 1 | Transporter | WOMBAT-PK | |||||||
Multidrug resistance-associated protein 1 | Transporter | WOMBAT-PK | |||||||
Multidrug resistance-associated protein 7 | Transporter | WOMBAT-PK | |||||||
Multidrug resistance protein 1 | Transporter | Ki | 7 | CHEMBL | |||||
Thromboxane-A synthase | Enzyme | IC50 | 5.73 | DRUG MATRIX | |||||
Arachidonate 15-lipoxygenase | Enzyme | IC50 | 5.30 | DRUG MATRIX | |||||
Amine oxidase [flavin-containing] B | Enzyme | Ki | 4.11 | CHEMBL |
ID | Source |
---|---|
4019970 | VUID |
N0000148055 | NUI |
D01068 | KEGG_DRUG |
143-67-9 | SECONDARY_CAS_RN |
4017457 | VANDF |
4019970 | VANDF |
C0042670 | UMLSCUI |
CHEBI:27375 | CHEBI |
VLB | PDB_CHEM_ID |
CHEMBL159 | ChEMBL_ID |
CHEMBL508191 | ChEMBL_ID |
CHEMBL378544 | ChEMBL_ID |
D014747 | MESH_DESCRIPTOR_UI |
DB00570 | DRUGBANK_ID |
6851 | IUPHAR_LIGAND_ID |
1101 | INN_ID |
5V9KLZ54CY | UNII |
13342 | PUBCHEM_CID |
11198 | RXNORM |
5674 | MMSL |
7980 | MMSL |
856 | MMSL |
d00400 | MMSL |
002654 | NDDF |
002655 | NDDF |
12436009 | SNOMEDCT_US |
387051009 | SNOMEDCT_US |
387115000 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Vinblastine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-278 | INJECTION | 1 mg | INTRAVENOUS | ANDA | 12 sections |