vinflunine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
vinca alkaloids 3644 162652-95-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vinflunine
  • javlor
  • vinflunine ditartrate
inhibits tubulin assembly
  • Molecular weight: 816.94
  • Formula: C45H54F2N4O8
  • CLOGP: 5.37
  • LIPINSKI: 3
  • HAC: 12
  • HDO: 2
  • TPSA: 133.87
  • ALOGS: -5.16
  • ROTB: 10

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01CA05 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Vinca alkaloids and analogues
CHEBI has role CHEBI:35610 cytostatic

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Transitional cell carcinoma indication 27090000 DOID:2671

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.32 acidic
pKa2 13.35 acidic
pKa3 7.39 Basic
pKa4 6.11 Basic
pKa5 5.01 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tubulin beta Tumour-associated antigen INHIBITOR SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D09032 KEGG_DRUG
194468-36-5 SECONDARY_CAS_RN
C0672663 UMLSCUI
CHEBI:90241 CHEBI
CHEMBL2110725 ChEMBL_ID
CHEMBL2105629 ChEMBL_ID
DB11641 DRUGBANK_ID
C111217 MESH_SUPPLEMENTAL_RECORD_UI
7499 INN_ID
5BF646324K UNII
10629256 PUBCHEM_CID
013377 NDDF
013378 NDDF
698843001 SNOMEDCT_US

Pharmaceutical products:

None