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vinflunine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| vinca alkaloids | 3644 | 162652-95-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
inhibits tubulin assembly
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 57 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 3.364 | Moderate | 0.74 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 75.336 | Moderate | 0.74 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 3.076 | 10^-6 cm/s | Moderate | 0.74 |
| dh-clint | Dog hepatocyte intrinsic clearance | 13.614 | uL/min/10^6 cells | Moderate | 0.74 |
| dppb | Dog plasma protein binding (% unbound) | 8.940 | % | Moderate | 0.74 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 17.650 | % | Moderate | 0.74 |
| herg | hERG pIC50 | 4.863 | pIC50 | Moderate | 0.74 |
| hh-clint | Human hepatocyte intrinsic clearance | 8.472 | uL/min/10^6 cells | Moderate | 0.74 |
| hlm-clint | Human liver microsomal intrinsic clearance | 102.329 | uL/min/mg protein | Moderate | 0.74 |
| hppb | Human plasma protein binding (% unbound) | 13.440 | % | Moderate | 0.74 |
| kinase-safety-class | ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK3,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIM2,PRKDC,STK33,TEK,TGFBR1,ZAP70 | 31 | |||
| kinase-selectivity-class | EIF2AK3 | 1 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 64.714 | High | 0.81 | |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 44.978 | Moderate | 0.74 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 20.797 | Moderate | 0.74 | |
| mppb | Mouse plasma protein binding (% unbound) | 6.610 | Moderate | 0.74 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 86.099 | Moderate | 0.74 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 1 | |||
| pld-class | Phospholipidosis risk class (1 = positive, 0 = negative) | 1 | High | 0.81 | |
| pppb | Pig plasma protein binding (% unbound) | 15.520 | % | Moderate | 0.74 |
| rat-kpuu-brain | Rat brain Kpuu | 0.012 | % | High | 0.81 |
| rh-clint | Rat hepatocyte intrinsic clearance | 10.593 | uL/min/10^6 cells | Moderate | 0.74 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 21.280 | % | Moderate | 0.74 |
| rppb | Rat plasma protein binding (% unbound) | 8.410 | % | Moderate | 0.74 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 264.241 | uM | Moderate | 0.74 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L01CA05 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS Vinca alkaloids and analogues |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
Related Drugs by ATC class:
L01CA Vinca alkaloids and analogues 5 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Transitional cell carcinoma | indication | 27090000 | DOID:2671 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.32 | acidic |
| pKa2 | 13.35 | acidic |
| pKa3 | 7.39 | Basic |
| pKa4 | 6.11 | Basic |
| pKa5 | 5.01 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Tubulin beta | Tumour-associated antigen | INHIBITOR | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| D09032 | KEGG_DRUG |
| 194468-36-5 | SECONDARY_CAS_RN |
| C0672663 | UMLSCUI |
| CHEBI:90241 | CHEBI |
| CHEMBL2110725 | ChEMBL_ID |
| CHEMBL2105629 | ChEMBL_ID |
| DB11641 | DRUGBANK_ID |
| C111217 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7499 | INN_ID |
| 5BF646324K | UNII |
| 10629256 | PUBCHEM_CID |
| 013377 | NDDF |
| 013378 | NDDF |
| 16666811000001104 | SNOMEDCT_US |
| 698843001 | SNOMEDCT_US |
Pharmaceutical products:
None