vincristine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
vinca alkaloids	2825	57-22-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: vincristine (+)-Vincristine leucristine vincristin vinkristin 22-oxo-vincaleukoblastine vincristine sulfate oncovin	An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.) Molecular weight: 824.97 Formula: C46H56N4O10 CLOGP: 4.04 LIPINSKI: 2 HAC: 14 HDO: 3 TPSA: 171.17 ALOGS: -4.44 ROTB: 10 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

vincristine
(+)-Vincristine
leucristine
vincristin
vinkristin
22-oxo-vincaleukoblastine
vincristine sulfate
oncovin

An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)

Molecular weight: 824.97
Formula: C46H56N4O10
CLOGP: 4.04
LIPINSKI: 2
HAC: 14
HDO: 3
TPSA: 171.17
ALOGS: -4.44
ROTB: 10

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	10 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	15 %	Benet LZ, Broccatelli F, Oprea TI
Vd (Volume of distribution)	2.40 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	2 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.40 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	23 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
July 10, 1963	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	3499.59	13.66	1977	64293	92650	46527142
Neutropenia	1354.71	13.66	1316	64954	141888	46477904
Febrile bone marrow aplasia	839.51	13.66	329	65941	6533	46613259
Product use in unapproved indication	638.05	13.66	711	65559	89562	46530230
Bone marrow failure	607.66	13.66	428	65842	29241	46590551
Haematotoxicity	546.43	13.66	243	66027	6690	46613102
Mucosal inflammation	537.14	13.66	444	65826	38532	46581260
Pancytopenia	521.94	13.66	623	65647	84435	46535357
Myelodysplastic syndrome	492.24	13.66	296	65974	15415	46604377
Diffuse large B-cell lymphoma recurrent	487.06	13.66	149	66121	1343	46618449
Posterior reversible encephalopathy syndrome	476.27	13.66	286	65984	14855	46604937
Second primary malignancy	475.13	13.66	217	66053	6367	46613425
Acute myeloid leukaemia	467.94	13.66	287	65983	15491	46604301
Thrombocytopenia	426.85	13.66	695	65575	125886	46493906
Tumour lysis syndrome	416.26	13.66	204	66066	7032	46612760
Sepsis	401.84	13.66	704	65566	135310	46484482
Venoocclusive liver disease	383.82	13.66	164	66106	4087	46615705
Septic shock	369.69	13.66	433	65837	57460	46562332
Diffuse large B-cell lymphoma	322.51	13.66	161	66109	5777	46614015
Rheumatoid arthritis	320.06	13.66	4	66266	240211	46379581
Acute lymphocytic leukaemia recurrent	319.41	13.66	118	66152	1977	46617815
Neurotoxicity	318.73	13.66	214	66056	13503	46606289
Hypofibrinogenaemia	303.64	13.66	96	66174	974	46618818
Pyrexia	294.82	13.66	1123	65147	347679	46272113
Ovarian failure	286.09	13.66	93	66177	1039	46618753
Neutropenic sepsis	280.90	13.66	190	66080	12134	46607658
Hepatitis B	279.98	13.66	126	66144	3567	46616225
Pain	274.05	13.66	170	66100	476778	46143014
Progressive multifocal leukoencephalopathy	249.28	13.66	171	66099	11175	46608617
Fall	238.42	13.66	85	66185	329012	46290780
Acute lymphocytic leukaemia	237.26	13.66	103	66167	2670	46617122
Staphylococcal bacteraemia	223.04	13.66	118	66152	4786	46615006
Maternal exposure before pregnancy	218.58	13.66	113	66157	4368	46615424
Cardiotoxicity	216.58	13.66	129	66141	6593	46613199
Diffuse large B-cell lymphoma refractory	214.75	13.66	72	66198	892	46618900
Disease recurrence	200.92	13.66	184	66086	18287	46601505
Haemophagocytic lymphohistiocytosis	195.82	13.66	131	66139	8211	46611581
Aplasia	194.31	13.66	97	66173	3479	46616313
Multiple organ dysfunction syndrome	190.52	13.66	296	65974	51414	46568378
Product dose omission issue	185.86	13.66	14	66256	168506	46451286
Off label use	184.30	13.66	1040	65230	378801	46240991
Neutrophil count decreased	183.43	13.66	265	66005	43161	46576631
Disease progression	180.96	13.66	400	65870	90900	46528892
Neuropathy peripheral	175.41	13.66	394	65876	90499	46529293
Joint swelling	174.40	13.66	17	66253	166056	46453736
Leukopenia	168.98	13.66	328	65942	68015	46551777
B-cell lymphoma recurrent	166.29	13.66	49	66221	383	46619409
Pneumocystis jirovecii pneumonia	166.04	13.66	152	66118	15096	46604696
Pruritus	164.73	13.66	69	66201	242283	46377509
Hypertriglyceridaemia	164.58	13.66	102	66168	5602	46614190
Ileus paralytic	163.29	13.66	92	66178	4231	46615561
Drug hypersensitivity	163.21	13.66	71	66199	243754	46376038
Post transplant lymphoproliferative disorder	161.94	13.66	88	66182	3768	46616024
Neutropenic colitis	159.23	13.66	73	66197	2159	46617633
Nasopharyngitis	158.49	13.66	17	66253	153981	46465811
Platelet count decreased	157.83	13.66	401	65869	99623	46520169
Dizziness	155.09	13.66	153	66117	340261	46279531
Myelosuppression	154.95	13.66	110	66160	7593	46612199
Drug resistance	154.75	13.66	155	66115	17213	46602579
Headache	153.98	13.66	278	65992	478074	46141718
Fatigue	153.00	13.66	406	65864	608291	46011501
Neoplasm progression	151.25	13.66	188	66082	26495	46593297
Epstein-Barr virus infection	146.07	13.66	101	66169	6683	46613109
Arthralgia	144.11	13.66	184	66086	364419	46255373
Abdominal discomfort	140.49	13.66	23	66247	151142	46468650
Hyperbilirubinaemia	139.67	13.66	117	66153	10321	46609471
Neoplasm recurrence	136.75	13.66	67	66203	2306	46617486
Anxiety	135.00	13.66	45	66225	181912	46437880
Peripheral swelling	134.30	13.66	30	66240	158041	46461751
Cardiomyopathy	129.70	13.66	136	66134	15937	46603855
Feeling abnormal	125.65	13.66	15	66255	125045	46494747
Cytopenia	122.83	13.66	96	66174	7672	46612120
Leukoencephalopathy	121.64	13.66	74	66196	3930	46615862
Hepatitis B reactivation	119.05	13.66	53	66217	1461	46618331
Mucormycosis	118.16	13.66	60	66210	2232	46617560
Injection site pain	117.81	13.66	9	66261	107143	46512649
Malignant neoplasm progression	116.96	13.66	274	65996	64652	46555140
Insomnia	116.83	13.66	44	66226	164880	46454912
Weight increased	116.31	13.66	44	66226	164429	46455363
Bacteraemia	116.25	13.66	121	66149	14058	46605734
Pneumatosis intestinalis	116.17	13.66	57	66213	1968	46617824
Rash	114.70	13.66	207	66063	356305	46263487
Blood culture positive	111.08	13.66	73	66197	4439	46615353
Temporal lobe epilepsy	107.17	13.66	34	66236	349	46619443
Cerebral venous thrombosis	104.77	13.66	54	66216	2073	46617719
Malaise	103.25	13.66	196	66074	331036	46288756
Disseminated intravascular coagulation	101.49	13.66	130	66140	18875	46600917
Drug ineffective	100.86	13.66	559	65711	677279	45942513
Secondary immunodeficiency	98.84	13.66	41	66229	946	46618846
Lymphopenia	98.51	13.66	115	66155	15178	46604614
Blood lactate dehydrogenase increased	96.78	13.66	132	66138	20368	46599424
Contraindicated product administered	96.19	13.66	4	66266	79943	46539849
Lennox-Gastaut syndrome	96.12	13.66	29	66241	248	46619544
Dyspnoea	95.98	13.66	392	65878	515156	46104636
White blood cell count decreased	95.57	13.66	363	65907	111868	46507924
Myelopathy	95.54	13.66	54	66216	2498	46617294
Systemic candida	94.85	13.66	55	66215	2672	46617120
Polyneuropathy	94.79	13.66	99	66171	11545	46608247
Stem cell transplant	93.29	13.66	47	66223	1719	46618073
Sinusitis	92.93	13.66	34	66236	129734	46490058
Hypogammaglobulinaemia	92.08	13.66	70	66200	5368	46614424
Fungaemia	90.79	13.66	48	66222	1943	46617849
Arthropathy	90.65	13.66	8	66262	84692	46535100
Asthma	89.46	13.66	12	66258	91530	46528262
Musculoskeletal stiffness	88.61	13.66	16	66254	97977	46521815
Pain in extremity	86.91	13.66	146	66124	258534	46361258
Blood pressure increased	86.06	13.66	36	66234	126630	46493162
Drug intolerance	86.05	13.66	51	66219	146998	46472794
Venoocclusive disease	85.93	13.66	46	66224	1910	46617882
Hepatocellular injury	85.84	13.66	152	66118	29370	46590422
Pleural effusion	84.00	13.66	284	65986	82668	46537124
Overdose	83.33	13.66	21	66249	101958	46517834
Central nervous system lymphoma	83.18	13.66	39	66231	1215	46618577
Swelling	82.03	13.66	37	66233	124474	46495318
Hepatic failure	80.85	13.66	159	66111	33257	46586535
Cerebral venous sinus thrombosis	80.40	13.66	43	66227	1782	46618010
Epstein-Barr virus associated lymphoproliferative disorder	80.00	13.66	40	66230	1439	46618353
Infection	79.71	13.66	388	65882	133204	46486588
Nephroblastoma	79.26	13.66	21	66249	105	46619687
Depression	78.98	13.66	75	66195	170029	46449763
Anaemia	78.61	13.66	626	65644	255153	46364639
Arthritis	78.32	13.66	9	66261	77307	46542485
Injection site erythema	77.07	13.66	8	66262	74419	46545373
Enterococcal infection	76.74	13.66	70	66200	6917	46612875
Muscle spasms	75.91	13.66	40	66230	123073	46496719
Ejection fraction decreased	75.02	13.66	109	66161	17828	46601964
Drug abuse	73.61	13.66	4	66266	63404	46556388
Ascites	73.19	13.66	161	66109	36423	46583369
B-cell lymphoma	73.17	13.66	50	66220	3244	46616548
Leukaemia recurrent	72.57	13.66	36	66234	1273	46618519
Clostridium difficile colitis	72.21	13.66	109	66161	18444	46601348
Bronchopulmonary aspergillosis	70.66	13.66	69	66201	7427	46612365
Respiratory failure	70.50	13.66	294	65976	94522	46525270
Synovitis	70.44	13.66	4	66266	61071	46558721
Palpitations	69.82	13.66	24	66246	95235	46524557
Bone pain	69.76	13.66	184	66086	46706	46573086
Nausea	69.32	13.66	634	65636	686820	45932972
Smooth muscle cell neoplasm	68.85	13.66	27	66243	536	46619256
Peripheral motor neuropathy	68.48	13.66	36	66234	1440	46618352
Stomatitis	68.40	13.66	233	66037	68064	46551728
Bronchitis	67.48	13.66	33	66237	105946	46513846
Superior sagittal sinus thrombosis	67.35	13.66	30	66240	828	46618964
Gene mutation	66.77	13.66	32	66238	1048	46618744
Enterococcal bacteraemia	65.77	13.66	33	66237	1196	46618596
B precursor type acute leukaemia	65.58	13.66	20	66250	178	46619614
Cystitis haemorrhagic	65.28	13.66	48	66222	3499	46616293
Hospitalisation	65.15	13.66	7	66263	63378	46556414
Pseudomonas test positive	64.76	13.66	28	66242	718	46619074
Chest pain	64.42	13.66	94	66176	176230	46443562
Contusion	64.19	13.66	22	66248	87465	46532327
Aspergillus infection	64.16	13.66	63	66207	6827	46612965
Klebsiella infection	64.06	13.66	62	66208	6600	46613192
Encephalopathy	64.03	13.66	145	66125	33444	46586348
Therapy partial responder	63.71	13.66	53	66217	4629	46615163
Peripheral sensory neuropathy	62.65	13.66	61	66209	6542	46613250
Inappropriate schedule of product administration	62.39	13.66	9	66261	65004	46554788
Migraine	62.09	13.66	12	66258	70014	46549778
Agranulocytosis	60.38	13.66	111	66159	22074	46597718
Colitis	60.14	13.66	151	66119	37196	46582596
Rhinovirus infection	59.80	13.66	46	66224	3590	46616202
Retinoblastoma	59.70	13.66	17	66253	116	46619676
Urticaria	59.51	13.66	48	66222	117844	46501948
Myeloid leukaemia	59.27	13.66	21	66249	310	46619482
Lymphadenopathy	58.82	13.66	140	66130	33348	46586444
Cytomegalovirus infection	58.76	13.66	98	66172	18046	46601746
Abdominal pain upper	58.62	13.66	72	66198	145233	46474559
Therapeutic product effect decreased	58.51	13.66	22	66248	82579	46537213
Refractory anaemia with an excess of blasts	57.23	13.66	22	66248	413	46619379
Escherichia bacteraemia	56.85	13.66	40	66230	2721	46617071
Lymphoma transformation	56.70	13.66	17	66253	142	46619650
Acute myelomonocytic leukaemia	55.86	13.66	18	66252	195	46619597
Ileus	55.26	13.66	83	66187	13981	46605811
Congestive cardiomyopathy	54.62	13.66	53	66217	5660	46614132
Venous thrombosis	52.86	13.66	48	66222	4714	46615078
Injection site reaction	52.62	13.66	4	66266	47845	46571947
Respiratory distress	52.40	13.66	130	66140	31786	46588006
Condition aggravated	52.17	13.66	176	66094	244876	46374916
Intentional product misuse	51.66	13.66	4	66266	47124	46572668
Sleep disorder	51.22	13.66	4	66266	46791	46573001
Fusarium infection	51.18	13.66	22	66248	556	46619236
Human bocavirus infection	51.00	13.66	19	66251	326	46619466
Hepatomegaly	50.91	13.66	71	66199	11182	46608610
Pneumocystis jirovecii infection	50.88	13.66	28	66242	1229	46618563
Pulmonary haemorrhage	50.62	13.66	54	66216	6451	46613341
Antithrombin III decreased	50.12	13.66	18	66252	277	46619515
Glioma	50.06	13.66	18	66252	278	46619514
Osteonecrosis	50.03	13.66	112	66158	25632	46594160
Left ventricular dysfunction	49.86	13.66	67	66203	10188	46609604
Bacterial sepsis	49.83	13.66	41	66229	3526	46616266
Heart rate abnormal	49.56	13.66	40	66230	3347	46616445
Ototoxicity	49.39	13.66	26	66244	1043	46618749
Suicidal ideation	49.27	13.66	10	66260	56372	46563420
Candida infection	49.23	13.66	102	66168	22138	46597654
Cervix disorder	48.64	13.66	20	66250	451	46619341
Device related infection	48.35	13.66	98	66172	20943	46598849
Osteoarthritis	48.34	13.66	14	66256	62011	46557781
Herpes simplex	47.66	13.66	55	66215	7168	46612624
Hyperglycaemia	47.53	13.66	133	66137	34938	46584854
Quadriplegia	47.43	13.66	30	66240	1707	46618085
Human herpesvirus 6 infection	47.14	13.66	34	66236	2405	46617387
Blood fibrinogen decreased	46.84	13.66	22	66248	688	46619104
Premature menopause	46.81	13.66	22	66248	689	46619103
Hyperhidrosis	46.79	13.66	35	66235	89273	46530519
Influenza like illness	46.74	13.66	12	66258	57558	46562234
Pyomyositis	46.19	13.66	18	66252	351	46619441
Enterovirus test positive	46.17	13.66	14	66256	122	46619670
Philadelphia chromosome positive	46.16	13.66	17	66253	282	46619510
Lymphoma	46.02	13.66	63	66207	9750	46610042
Staphylococcal sepsis	45.79	13.66	55	66215	7477	46612315
Cutaneous calcification	45.74	13.66	13	66257	88	46619704
Lung infiltration	45.67	13.66	76	66194	13967	46605825
Diarrhoea	45.65	13.66	542	65728	559060	46060732
Myalgia	45.54	13.66	65	66205	123023	46496769
Toxic neuropathy	45.41	13.66	18	66252	368	46619424
Leukaemia cutis	45.24	13.66	13	66257	92	46619700
Gastrooesophageal reflux disease	44.58	13.66	25	66245	74319	46545473
Pneumonia fungal	44.36	13.66	41	66229	4119	46615673
Neck pain	44	13.66	12	66258	55294	46564498
Choriocarcinoma	43.96	13.66	13	66257	103	46619689
Brain oedema	43.93	13.66	70	66200	12408	46607384
Mantle cell lymphoma recurrent	43.11	13.66	13	66257	111	46619681
Enterobacter infection	42.76	13.66	29	66241	1858	46617934
Injection site swelling	42.62	13.66	4	66266	40323	46579469
Loss of personal independence in daily activities	42.60	13.66	14	66256	57169	46562623
Urinary tract infection	42.36	13.66	165	66105	220101	46399691
B-cell lymphoma refractory	42.12	13.66	12	66258	82	46619710
Incorrect dose administered	42.12	13.66	7	66263	45543	46574249
Osteomyelitis bacterial	42.01	13.66	14	66256	170	46619622
5q minus syndrome	41.86	13.66	14	66256	172	46619620
Injection site pruritus	41.85	13.66	4	66266	39739	46580053
Suicide attempt	41.84	13.66	13	66257	55023	46564769
Hot flush	41.81	13.66	6	66264	43511	46576281
Human rhinovirus test positive	41.64	13.66	13	66257	126	46619666
Inappropriate antidiuretic hormone secretion	41.49	13.66	73	66197	14029	46605763
Back pain	41.25	13.66	156	66114	209883	46409909
Mucosal toxicity	41.01	13.66	16	66254	313	46619479
Intussusception	40.95	13.66	18	66252	481	46619311
Wound	40.89	13.66	6	66264	42796	46576996
Somnolence	40.88	13.66	102	66168	156419	46463373
Cerebrovascular accident	40.80	13.66	50	66220	100989	46518803
Herpes zoster meningoencephalitis	40.78	13.66	15	66255	248	46619544
Hepatitis E	40.49	13.66	24	66246	1215	46618577
Humoral immune defect	40.27	13.66	11	66259	63	46619729
Hypoalbuminaemia	40.12	13.66	60	66210	10067	46609725
Alopecia	40.00	13.66	109	66161	162305	46457487
Histiocytic sarcoma	39.70	13.66	11	66259	67	46619725
Myocardial infarction	39.66	13.66	48	66222	97480	46522312
Combined immunodeficiency	39.63	13.66	12	66258	104	46619688
Perineal necrosis	39.33	13.66	12	66258	107	46619685
Epstein-Barr virus associated lymphoma	39.25	13.66	15	66255	277	46619515
Loss of consciousness	39.21	13.66	58	66212	108180	46511612
Cough	39.03	13.66	181	66089	230068	46389724
Coagulopathy	38.80	13.66	83	66187	18416	46601376
JC virus infection	38.76	13.66	26	66244	1636	46618156
Gastrosplenic fistula	38.61	13.66	10	66260	45	46619747
Transverse sinus thrombosis	38.58	13.66	19	66251	661	46619131
Medulloblastoma recurrent	38.51	13.66	11	66259	76	46619716
Dry mouth	38.27	13.66	15	66255	54911	46564881
Astrocytoma, low grade	38.08	13.66	10	66260	48	46619744
Injury	38.07	13.66	8	66262	44019	46575773
Blood glucose increased	38.01	13.66	28	66242	71985	46547807
Perineal infection	37.84	13.66	12	66258	123	46619669
Plasmablastic lymphoma	37.81	13.66	14	66256	236	46619556
Gastroenteritis norovirus	37.63	13.66	25	66245	1548	46618244
Growth hormone deficiency	37.41	13.66	12	66258	128	46619664
Unmasking of previously unidentified disease	37.28	13.66	19	66251	712	46619080
Cardiac failure	37.23	13.66	217	66053	79731	46540061
Bone marrow disorder	36.93	13.66	26	66244	1770	46618022
Platelet count abnormal	36.93	13.66	31	66239	2741	46617051
Lymphadenitis	36.51	13.66	30	66240	2575	46617217
Adverse drug reaction	36.48	13.66	9	66261	44353	46575439
Therapeutic response delayed	36.19	13.66	17	66253	532	46619260
Chest discomfort	36.10	13.66	45	66225	90224	46529568
Depressed mood	36.04	13.66	3	66267	33316	46586476
Vision blurred	35.96	13.66	36	66234	79672	46540120
Acute promyelocytic leukaemia	35.87	13.66	20	66250	901	46618891
Oedema peripheral	35.83	13.66	112	66158	159594	46460198
Lymphoproliferative disorder	35.65	13.66	30	66240	2662	46617130
Clostridium test positive	35.57	13.66	26	66244	1878	46617914
Listeria sepsis	35.21	13.66	17	66253	566	46619226
Recurrent cancer	35.10	13.66	25	66245	1734	46618058
Unevaluable event	34.93	13.66	11	66259	46164	46573628
Malignant transformation	34.66	13.66	14	66256	301	46619491
Burning sensation	34.65	13.66	10	66260	44401	46575391
Cytomegalovirus viraemia	34.54	13.66	37	66233	4441	46615351
Bacterial infection	34.29	13.66	73	66197	16143	46603649
Acute hepatitis B	34.24	13.66	14	66256	311	46619481
Glioblastoma multiforme	34.05	13.66	19	66251	857	46618935
T-cell lymphoma	33.99	13.66	17	66253	612	46619180
Cytomegalovirus chorioretinitis	33.77	13.66	23	66247	1484	46618308
Discomfort	33.77	13.66	12	66258	46658	46573134
Erythropoiesis abnormal	33.72	13.66	13	66257	246	46619546
Tremor	33.71	13.66	71	66199	115568	46504224
Memory impairment	33.68	13.66	36	66234	77301	46542491
Femur fracture	33.52	13.66	6	66264	36991	46582801
Nail pigmentation	33.45	13.66	12	66258	184	46619608
Cytogenetic abnormality	33.44	13.66	16	66254	522	46619270
Leukaemic lymphoma	33.41	13.66	10	66260	83	46619709
Infection reactivation	32.94	13.66	18	66252	779	46619013
Mobility decreased	32.71	13.66	23	66247	60571	46559221
Pneumonia cytomegaloviral	32.68	13.66	25	66245	1935	46617857
Areflexia	32.64	13.66	30	66240	2993	46616799
General physical health deterioration	32.58	13.66	278	65992	115491	46504301
Blast cells present	32.45	13.66	14	66256	357	46619435
Seizure	32.30	13.66	291	65979	122763	46497029
Blood pressure fluctuation	32.23	13.66	3	66267	30445	46589347
Cardiomyopathy acute	32.21	13.66	12	66258	206	46619586
Hemiparesis	32.15	13.66	81	66189	19988	46599804
Rhinocerebral mucormycosis	31.98	13.66	11	66259	148	46619644
Vocal cord paralysis	31.91	13.66	23	66247	1625	46618167
Cryptococcosis	31.82	13.66	18	66252	834	46618958
Hepatic infarction	31.68	13.66	16	66254	588	46619204
Oesophageal candidiasis	31.66	13.66	38	66232	5162	46614630
Subdural hygroma	31.48	13.66	12	66258	220	46619572
Leukoerythroblastosis	31.48	13.66	12	66258	220	46619572
Hyperammonaemia	31.26	13.66	36	66234	4680	46615112
Hypersensitivity	31.24	13.66	109	66161	150212	46469580
Capillary leak syndrome	31.20	13.66	24	66246	1873	46617919
Hallucination	31.11	13.66	16	66254	49935	46569857
Varicella zoster virus infection	30.80	13.66	26	66244	2317	46617475
Encephalitis	30.76	13.66	45	66225	7403	46612389
Cholestasis	30.73	13.66	96	66174	26797	46592995
Pseudomonas infection	30.65	13.66	52	66218	9706	46610086
Antithrombin III	30.58	13.66	11	66259	170	46619622
Acute respiratory distress syndrome	30.55	13.66	84	66186	21838	46597954
Trichodysplasia spinulosa	30.50	13.66	14	66256	415	46619377
Chronic kidney disease	30.45	13.66	10	66260	40861	46578931
White blood cell count abnormal	30.42	13.66	37	66233	5095	46614697
Candida test positive	30.12	13.66	18	66252	925	46618867
Gestational trophoblastic tumour	30.03	13.66	8	66262	41	46619751
Carotid intima-media thickness increased	29.83	13.66	9	66261	77	46619715
Therapy responder	29.76	13.66	13	66257	342	46619450
Ureaplasma infection	29.54	13.66	14	66256	447	46619345
Nasal congestion	29.10	13.66	16	66254	48097	46571695
Musculoskeletal pain	29.05	13.66	34	66236	70094	46549698
Hyperpyrexia	28.99	13.66	27	66243	2739	46617053
Klebsiella bacteraemia	28.88	13.66	19	66251	1157	46618635
Feeling hot	28.75	13.66	9	66261	37919	46581873
Acute biphenotypic leukaemia	28.70	13.66	8	66262	50	46619742
Nephrolithiasis	28.59	13.66	6	66264	33045	46586747
Hepatotoxicity	28.32	13.66	89	66181	24920	46594872
Desmoplastic small round cell tumour	28.08	13.66	10	66260	150	46619642
Pseudomonal sepsis	27.94	13.66	23	66247	1979	46617813
Product quality issue	27.86	13.66	8	66262	35640	46584152
Therapy non-responder	27.78	13.66	124	66146	41028	46578764
International normalised ratio increased	27.76	13.66	16	66254	46867	46572925
Surgery	27.58	13.66	4	66266	28781	46591011
Subclavian vein thrombosis	27.43	13.66	22	66248	1824	46617968
Flushing	27.12	13.66	31	66239	64583	46555209
Leukaemia	26.79	13.66	28	66242	3267	46616525
B-cell type acute leukaemia	26.59	13.66	9	66261	115	46619677
Cerebellar stroke	26.56	13.66	10	66260	177	46619615
Paraparesis	26.48	13.66	22	66248	1917	46617875
Dyspepsia	26.48	13.66	35	66235	68437	46551355
BK virus infection	26.43	13.66	26	66244	2823	46616969
Premature delivery	26.35	13.66	80	66190	21989	46597803
Escherichia test positive	26.16	13.66	22	66248	1950	46617842
Pulse waveform abnormal	26.15	13.66	8	66262	72	46619720
Potentiating drug interaction	26.10	13.66	30	66240	3893	46615899
Sinusitis fungal	26.09	13.66	16	66254	862	46618930
Ankle brachial index decreased	26.06	13.66	8	66262	73	46619719
Ocular vascular disorder	25.86	13.66	12	66258	365	46619427
Rhinorrhoea	25.84	13.66	18	66252	47647	46572145
Toxic cardiomyopathy	25.71	13.66	9	66261	128	46619664
Acquired gene mutation	25.70	13.66	14	66256	602	46619190
Emotional distress	25.70	13.66	6	66264	30701	46589091
Traumatic lung injury	25.53	13.66	19	66251	1411	46618381
Flatulence	25.48	13.66	5	66265	28873	46590919
Hypertransaminasaemia	25.47	13.66	28	66242	3460	46616332
Haemorrhage intracranial	25.44	13.66	56	66214	12668	46607124
Joint stiffness	25.43	13.66	4	66266	27104	46592688
Metastasis	25.42	13.66	31	66239	4281	46615511
Refractory cytopenia with multilineage dysplasia	25.39	13.66	9	66261	133	46619659
Haemolytic uraemic syndrome	25.31	13.66	24	66246	2490	46617302
Tumour necrosis	25.29	13.66	15	66255	760	46619032
Primary immunodeficiency syndrome	25.21	13.66	7	66263	43	46619749
Heart rate decreased	25.01	13.66	7	66263	31716	46588076
Weight decreased	24.92	13.66	186	66084	210663	46409129
Hepatitis C RNULL increased	24.68	13.66	9	66261	145	46619647
Mucoepidermoid carcinoma	24.68	13.66	7	66263	47	46619745
Bone marrow transplant	24.60	13.66	14	66256	656	46619136
Clostridium difficile infection	24.55	13.66	85	66185	25018	46594774
Metastases to meninges	24.54	13.66	21	66249	1906	46617886
Chronic hepatitis	24.44	13.66	15	66255	809	46618983
Intestinal perforation	24.29	13.66	50	66220	10801	46608991
Wheezing	24.21	13.66	24	66246	53362	46566430
Hereditary motor and sensory neuropathy	24.18	13.66	7	66263	51	46619741
Pneumonia	24.18	13.66	702	65568	375618	46244174
IIIrd nerve paralysis	24.16	13.66	14	66256	679	46619113
Rhabdomyosarcoma recurrent	24.14	13.66	6	66264	22	46619770
Soft tissue infection	24.05	13.66	21	66249	1959	46617833
Alveolar soft part sarcoma	23.87	13.66	8	66262	99	46619693
Streptococcus test positive	23.70	13.66	17	66253	1192	46618600
Angioimmunoblastic T-cell lymphoma	23.58	13.66	8	66262	103	46619689
Small intestinal obstruction	23.57	13.66	63	66207	16109	46603683
Localised infection	23.53	13.66	3	66267	23798	46595994
Throat irritation	23.50	13.66	6	66264	28895	46590897
Influenza	23.43	13.66	58	66212	89212	46530580
Angiocentric lymphoma	23.37	13.66	12	66258	457	46619335
Pulmonary toxicity	23.33	13.66	31	66239	4662	46615130
Encephalitis viral	23.32	13.66	19	66251	1611	46618181
Geotrichum infection	23.30	13.66	12	66258	460	46619332
Partial seizures	23.25	13.66	32	66238	4978	46614814
Fluid retention	23.08	13.66	23	66247	51023	46568769
Blood immunoglobulin G decreased	23.07	13.66	20	66250	1848	46617944
Gastrointestinal necrosis	23.01	13.66	24	66246	2794	46616998
Gastric stenosis	22.98	13.66	7	66263	62	46619730
Staphylococcal infection	22.82	13.66	106	66164	35665	46584127
Gastric disorder	22.79	13.66	5	66265	26700	46593092
Multiple sclerosis	22.50	13.66	4	66266	24787	46595005
Paraplegia	22.49	13.66	22	66248	2372	46617420
Angioedema	22.49	13.66	14	66256	39328	46580464
Hepatic enzyme increased	22.36	13.66	52	66218	81735	46538057
Dysgeusia	22.34	13.66	15	66255	40476	46579316
T-cell type acute leukaemia	22.32	13.66	7	66263	69	46619723
Neutropenic infection	22.31	13.66	16	66254	1122	46618670
Head injury	22.31	13.66	4	66266	24632	46595160
Cytomegalovirus colitis	22.29	13.66	19	66251	1716	46618076
Renal replacement therapy	22.17	13.66	6	66264	33	46619759
Renal vein thrombosis	22.12	13.66	10	66260	286	46619506
Acute lymphocytic leukaemia refractory	22.05	13.66	7	66263	72	46619720
Cytokine release syndrome	22.03	13.66	35	66235	6188	46613604
Visual impairment	22.00	13.66	38	66232	66651	46553141
Premature baby	21.95	13.66	66	66204	18046	46601746
Alveolar rhabdomyosarcoma	21.73	13.66	6	66264	36	46619756
Dry eye	21.59	13.66	8	66262	30314	46589478
Death	21.49	13.66	341	65929	335207	46284585
Necrotising gastritis	21.45	13.66	6	66264	38	46619754
Hepatosplenic candidiasis	21.45	13.66	9	66261	214	46619578
Gait disturbance	21.29	13.66	120	66150	145143	46474649
Chronic myelomonocytic leukaemia	21.25	13.66	10	66260	314	46619478
Autonomic neuropathy	21.17	13.66	13	66257	702	46619090
Skin discolouration	21.05	13.66	10	66260	32670	46587122
Pharyngeal inflammation	21.00	13.66	12	66258	567	46619225
Blood stem cell transplant failure	20.97	13.66	8	66262	147	46619645
Escherichia infection	20.94	13.66	47	66223	10770	46609022
Platelet transfusion	20.94	13.66	13	66257	716	46619076
SARS-CoV-2 test negative	20.93	13.66	7	66263	86	46619706
Confusional state	20.87	13.66	137	66133	159755	46460037
Jejunal stenosis	20.81	13.66	6	66264	43	46619749
Hypoglycaemia	20.79	13.66	28	66242	54321	46565471
Duodenal stenosis	20.75	13.66	12	66258	580	46619212
Epstein Barr virus positive mucocutaneous ulcer	20.74	13.66	9	66261	233	46619559
Haemoglobin abnormal	20.44	13.66	28	66242	4335	46615457
Pneumonia influenzal	20.36	13.66	17	66253	1492	46618300
Dry skin	20.31	13.66	17	66253	40999	46578793
Neutrophil count abnormal	20.24	13.66	21	66249	2429	46617363
Peritonitis viral	20.24	13.66	6	66264	48	46619744
Atypical haemolytic uraemic syndrome	20.11	13.66	11	66259	477	46619315
Abnormal behaviour	20	13.66	3	66267	21055	46598737
Wrong technique in product usage process	19.86	13.66	29	66241	54393	46565399
Parainfluenzae virus infection	19.84	13.66	18	66252	1766	46618026
Blood pressure systolic increased	19.83	13.66	8	66262	28779	46591013
Disturbance in attention	19.81	13.66	10	66260	31550	46588242
Cerebral artery thrombosis	19.76	13.66	10	66260	369	46619423
Serotonin syndrome	19.75	13.66	5	66265	24215	46595577
Mucosal infection	19.72	13.66	7	66263	104	46619688
Coronavirus infection	19.66	13.66	22	66248	2772	46617020
Brain injury	19.62	13.66	33	66237	6117	46613675
Congenital retinoblastoma	19.58	13.66	5	66265	21	46619771
Paranasal sinus mucosal hypertrophy	19.58	13.66	5	66265	21	46619771
Iris atrophy	19.52	13.66	6	66264	55	46619737
Adenovirus infection	19.43	13.66	22	66248	2808	46616984
Leukaemic infiltration	19.39	13.66	5	66265	22	46619770
Central nervous system enteroviral infection	19.39	13.66	5	66265	22	46619770
Respiratory arrest	19.38	13.66	12	66258	33804	46585988
Delayed puberty	19.36	13.66	7	66263	110	46619682
Erythema	19.33	13.66	121	66149	142699	46477093
Balance disorder	19.31	13.66	39	66231	64482	46555310
Listeria encephalitis	19.31	13.66	8	66262	184	46619608
Ocular lymphoma	19.23	13.66	6	66264	58	46619734
Haematocolpos	19.23	13.66	6	66264	58	46619734
Alanine aminotransferase increased	19.18	13.66	201	66069	88250	46531542
Peripheral sensorimotor neuropathy	19.14	13.66	15	66255	1203	46618589
Chronic lymphocytic leukaemia	18.99	13.66	22	66248	2878	46616914
Rectal adenoma	18.88	13.66	6	66264	62	46619730
Chronic obstructive pulmonary disease	18.87	13.66	33	66237	57600	46562192
Oropharyngeal pain	18.83	13.66	49	66221	74119	46545673
Cataract	18.83	13.66	22	66248	45393	46574399
Nervous system disorder	18.82	13.66	58	66212	16071	46603721
Rash pruritic	18.78	13.66	21	66249	44194	46575598
Jugular vein thrombosis	18.75	13.66	21	66249	2649	46617143
Swollen tongue	18.75	13.66	9	66261	29223	46590569
Hepatosplenomegaly	18.74	13.66	20	66250	2390	46617402
Vulvovaginitis	18.72	13.66	9	66261	297	46619495
Tooth disorder	18.64	13.66	5	66265	23298	46596494
Hepatitis acute	18.56	13.66	38	66232	8176	46611616
Acne	18.55	13.66	3	66267	19916	46599876
Primary mediastinal large B-cell lymphoma recurrent	18.54	13.66	6	66264	66	46619726
Meningoencephalitis herpetic	18.52	13.66	14	66256	1064	46618728
Generalised tonic-clonic seizure	18.51	13.66	82	66188	27040	46592752
Vulvovaginal inflammation	18.48	13.66	11	66259	561	46619231
Urinary tract infection bacterial	18.42	13.66	26	66244	4139	46615653
Adverse event	18.41	13.66	13	66257	34171	46585621
Inflammatory myofibroblastic tumour	18.40	13.66	5	66265	28	46619764
Mantle cell lymphoma	18.15	13.66	11	66259	580	46619212
Post lumbar puncture syndrome	18.15	13.66	11	66259	580	46619212
Red blood cell sedimentation rate increased	18.14	13.66	5	66265	22884	46596908
Blood cholesterol increased	18.13	13.66	18	66252	39995	46579797
Foot fracture	18.12	13.66	3	66267	19579	46600213
Underdose	18.09	13.66	3	66267	19555	46600237
Escherichia sepsis	18.08	13.66	26	66244	4212	46615580
Blood bilirubin increased	18.04	13.66	96	66174	34088	46585704
Limb discomfort	18.00	13.66	5	66265	22771	46597021
Graft versus host disease	17.97	13.66	33	66237	6555	46613237
Coronary artery disease	17.96	13.66	13	66257	33739	46586053
Salivary gland cancer	17.94	13.66	7	66263	137	46619655
Skin ulcer	17.94	13.66	12	66258	32446	46587346
Retinal pigment epitheliopathy	17.92	13.66	8	66262	222	46619570
Candida sepsis	17.89	13.66	15	66255	1324	46618468
Bacillus infection	17.89	13.66	9	66261	328	46619464
Cardiopulmonary failure	17.88	13.66	24	66246	3645	46616147
Acute leukaemia	17.85	13.66	14	66256	1124	46618668
Acute monocytic leukaemia	17.84	13.66	6	66264	75	46619717
Restlessness	17.73	13.66	7	66263	25517	46594275
Oedema due to cardiac disease	17.70	13.66	5	66265	33	46619759
Intracardiac thrombus	17.68	13.66	19	66251	2289	46617503
Urethritis	17.66	13.66	8	66262	230	46619562
Joint injury	17.65	13.66	3	66267	19206	46600586
Lower respiratory tract infection	17.62	13.66	32	66238	55057	46564735
Amnesia	17.44	13.66	20	66250	41611	46578181
Myeloproliferative neoplasm	17.33	13.66	10	66260	481	46619311
Haematoma	17.33	13.66	12	66258	31860	46587932
Primary cardiac lymphoma	17.33	13.66	5	66265	36	46619756
Blood magnesium decreased	17.23	13.66	44	66226	10948	46608844
Precursor T-lymphoblastic lymphoma/leukaemia	17.21	13.66	5	66265	37	46619755
Splenic necrosis	17.21	13.66	5	66265	37	46619755
Axonal neuropathy	17.19	13.66	13	66257	989	46618803
Chronic hepatitis B	17.13	13.66	8	66262	247	46619545
Bacillus test positive	17.09	13.66	5	66265	38	46619754
Blast crisis in myelogenous leukaemia	17.02	13.66	10	66260	498	46619294
Cauda equina syndrome	16.99	13.66	11	66259	652	46619140
Flagellate dermatitis	16.98	13.66	7	66263	159	46619633
Heart rate irregular	16.87	13.66	3	66267	18588	46601204
Enteral nutrition	16.87	13.66	5	66265	40	46619752
Chromosomal deletion	16.87	13.66	5	66265	40	46619752
Swelling face	16.81	13.66	31	66239	53028	46566764
Acidosis	16.76	13.66	44	66226	11130	46608662
Haemangioma-thrombocytopenia syndrome	16.68	13.66	3	66267	0	46619792
Bone marrow leukaemic cell infiltration	16.68	13.66	3	66267	0	46619792
Antithrombin III deficiency	16.68	13.66	3	66267	0	46619792
Central nervous system leukaemia	16.67	13.66	6	66264	93	46619699
Diffuse large B-cell lymphoma stage III	16.65	13.66	5	66265	42	46619750
Hyperkalaemia	16.63	13.66	29	66241	50680	46569112
Hypophosphataemia	16.55	13.66	34	66236	7333	46612459
Device issue	16.53	13.66	4	66266	19976	46599816
Lymphocytosis	16.43	13.66	18	66252	2216	46617576
Rectal fissure	16.42	13.66	10	66260	532	46619260
Hepatic function abnormal	16.38	13.66	94	66176	34327	46585465
Cardiac disorder	16.37	13.66	23	66247	43835	46575957
Aborted pregnancy	16.35	13.66	5	66265	45	46619747
Withdrawal syndrome	16.30	13.66	3	66267	18131	46601661
Nephropathy toxic	16.27	13.66	34	66236	7420	46612372
Lipase increased	16.23	13.66	37	66233	8566	46611226
Tachypnoea	16.18	13.66	51	66219	14300	46605492
Quadriparesis	16.18	13.66	16	66254	1748	46618044
Endocarditis	16.13	13.66	27	66243	4985	46614807
Encopresis	16.10	13.66	6	66264	103	46619689
Pancreatitis acute	16.08	13.66	74	66196	24798	46594994
Blister	16.07	13.66	24	66246	44607	46575185
Meningitis coccidioides	16.02	13.66	4	66266	15	46619777
Vertigo	15.97	13.66	31	66239	52017	46567775
B-lymphocyte count abnormal	15.97	13.66	5	66265	49	46619743
Therapy cessation	15.89	13.66	9	66261	26620	46593172
Beta 2 microglobulin decreased	15.82	13.66	4	66266	16	46619776
Pancreatic pseudocyst	15.81	13.66	10	66260	569	46619223
Intra-abdominal haemorrhage	15.81	13.66	18	66252	2312	46617480
Neuroblastoma	15.79	13.66	5	66265	51	46619741
Hyperviscosity syndrome	15.79	13.66	7	66263	191	46619601
Enterocolitis	15.71	13.66	30	66240	6138	46613654
Refractory cytopenia with unilineage dysplasia	15.68	13.66	10	66260	577	46619215
Fear of injection	15.62	13.66	24	66246	4123	46615669
Intestinal dilatation	15.57	13.66	15	66255	1587	46618205
Vascular compression	15.54	13.66	6	66264	114	46619678
Gastroenteritis salmonella	15.52	13.66	9	66261	437	46619355
Cranial nerve disorder	15.52	13.66	8	66262	307	46619485
Respiratory syncytial virus infection	15.50	13.66	26	66244	4809	46614983
Abdominal compartment syndrome	15.47	13.66	10	66260	591	46619201
Osteoporosis	15.45	13.66	21	66249	40587	46579205
Anal ulcer	15.45	13.66	9	66261	441	46619351
Anal injury	15.44	13.66	4	66266	18	46619774
Hypoaesthesia	15.43	13.66	102	66168	118767	46501025
Haemoglobin decreased	15.41	13.66	263	66007	128686	46491106
Myelitis	15.41	13.66	13	66257	1157	46618635
Splenomegaly	15.41	13.66	39	66231	9649	46610143
Interstitial lung disease	15.40	13.66	130	66140	53819	46565973
Pulmonary vascular disorder	15.31	13.66	8	66262	316	46619476
Staphylococcus test positive	15.30	13.66	22	66248	3562	46616230
Viral haemorrhagic cystitis	15.29	13.66	10	66260	603	46619189
Treatment failure	15.26	13.66	74	66196	93013	46526779
Hepatitis B surface antigen positive	15.21	13.66	5	66265	58	46619734
Subileus	15.18	13.66	20	66250	2983	46616809
Postictal state	15.13	13.66	12	66258	979	46618813
Malignant neoplasm of orbit	15.10	13.66	4	66266	20	46619772
Malnutrition	15.09	13.66	49	66221	13954	46605838
Brain herniation	15.08	13.66	20	66250	3003	46616789
Klebsiella test positive	15.07	13.66	12	66258	985	46618807
Hyporeflexia	15.03	13.66	16	66254	1906	46617886
Impaired healing	15.02	13.66	18	66252	36725	46583067
Porphyria non-acute	15.01	13.66	8	66262	329	46619463
Cardiac failure congestive	15.00	13.66	73	66197	91677	46528115
Adult T-cell lymphoma/leukaemia	14.90	13.66	8	66262	334	46619458
Ear infection	14.89	13.66	7	66263	23006	46596786
Diffuse large B-cell lymphoma stage IV	14.87	13.66	7	66263	220	46619572
Liver function test abnormal	14.87	13.66	27	66243	46460	46573332
Acute graft versus host disease	14.73	13.66	23	66247	4007	46615785
Laboratory test abnormal	14.70	13.66	7	66263	22840	46596952
Asthenia	14.69	13.66	333	65937	310742	46309050
Enterococcus test positive	14.61	13.66	12	66258	1029	46618763
Adenoviral haemorrhagic cystitis	14.60	13.66	6	66264	135	46619657
Ventriculo-peritoneal shunt	14.60	13.66	3	66267	3	46619789
Pancreatic infarction	14.60	13.66	3	66267	3	46619789
Vaginal obstruction	14.60	13.66	3	66267	3	46619789
Vulvovaginal adhesion	14.60	13.66	3	66267	3	46619789
Periorbital cellulitis	14.57	13.66	9	66261	491	46619301
Cardiac dysfunction	14.57	13.66	14	66256	1477	46618315
Febrile infection	14.55	13.66	13	66257	1250	46618542
Sopor	14.51	13.66	5	66265	19823	46599969
Cheyne-Stokes respiration	14.44	13.66	6	66264	139	46619653
Pyloric stenosis	14.42	13.66	8	66262	357	46619435
Eye irritation	14.40	13.66	3	66267	16611	46603181
Heart rate increased	14.36	13.66	56	66214	74735	46545057
Pseudomonal bacteraemia	14.30	13.66	13	66257	1278	46618514
Sarcoidosis	14.27	13.66	26	66244	5133	46614659
Osteosarcoma	14.25	13.66	6	66264	144	46619648
Encephalitis cytomegalovirus	14.22	13.66	9	66261	513	46619279
Campylobacter infection	14.15	13.66	10	66260	685	46619107
Myocardial oedema	14.10	13.66	5	66265	74	46619718
Graft versus host disease in skin	13.92	13.66	17	66253	2350	46617442
Liver abscess	13.89	13.66	18	66252	2641	46617151
Granulocytopenia	13.86	13.66	26	66244	5247	46614545
Rash macular	13.85	13.66	5	66265	19255	46600537
Cancer in remission	13.84	13.66	4	66266	29	46619763
Psychiatric decompensation	13.82	13.66	12	66258	1111	46618681
Eosinophilia	13.80	13.66	5	66265	19212	46600580
Electrocardiogram QT prolonged	13.73	13.66	33	66237	51292	46568500
Perirectal abscess	13.73	13.66	11	66259	911	46618881
Fungal test positive	13.67	13.66	9	66261	549	46619243

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	3674.21	12.79	2780	83889	103913	29761896
Neutropenia	1395.08	12.79	1783	84886	126757	29739052
Hepatitis B	685.51	12.79	340	86329	5732	29860077
Product use in unapproved indication	650.00	12.79	926	85743	72767	29793042
Mucosal inflammation	645.68	12.79	603	86066	29891	29835918
Febrile bone marrow aplasia	572.16	12.79	332	86337	7765	29858044
Second primary malignancy	562.02	12.79	302	86367	6054	29859755
Bone marrow failure	525.48	12.79	533	86136	29252	29836557
Diffuse large B-cell lymphoma recurrent	464.18	12.79	188	86481	1904	29863905
Myelodysplastic syndrome	455.55	12.79	401	86268	18377	29847432
Diffuse large B-cell lymphoma	421.72	12.79	270	86399	7571	29858238
Pancytopenia	418.57	12.79	823	85846	84229	29781580
Haematotoxicity	412.21	12.79	244	86425	5926	29859883
Venoocclusive liver disease	411.93	12.79	250	86419	6363	29859446
Tumour lysis syndrome	384.30	12.79	310	86359	12575	29853234
Posterior reversible encephalopathy syndrome	377.05	12.79	262	86407	8445	29857364
Acute myeloid leukaemia	376.93	12.79	354	86315	17652	29848157
Hepatitis B reactivation	351.29	12.79	170	86499	2707	29863102
Hypofibrinogenaemia	328.15	12.79	137	86532	1508	29864301
Myelosuppression	295.38	12.79	211	86458	7111	29858698
Pyrexia	284.86	12.79	1633	85036	292856	29572953
Progressive multifocal leukoencephalopathy	281.87	12.79	223	86446	8790	29857019
Off label use	277.02	12.79	1436	85233	247854	29617955
Leukopenia	268.20	12.79	537	86132	55622	29810187
Fall	257.94	12.79	102	86567	181770	29684039
Acute lymphocytic leukaemia	243.97	12.79	136	86533	2936	29862873
Thrombocytopenia	241.47	12.79	907	85762	136137	29729672
Pneumocystis jirovecii pneumonia	241.06	12.79	272	86397	16848	29848961
Sepsis	229.61	12.79	934	85735	145461	29720348
Neuropathy peripheral	221.63	12.79	571	86098	69904	29795905
Cytomegalovirus chorioretinitis	220.25	12.79	130	86539	3138	29862671
Acute lymphocytic leukaemia recurrent	219.83	12.79	121	86548	2546	29863263
Product dose omission issue	219.51	12.79	11	86658	91620	29774189
Neoplasm progression	213.33	12.79	262	86407	17761	29848048
Neutrophil count decreased	208.68	12.79	411	86258	42043	29823766
Death	198.37	12.79	466	86203	356817	29508992
Septic shock	194.46	12.79	510	86159	63097	29802712
Neutropenic sepsis	189.86	12.79	198	86471	11211	29854598
Diffuse large B-cell lymphoma refractory	186.83	12.79	74	86595	703	29865106
Myocardial infarction	182.02	12.79	68	86601	125557	29740252
Acquired gene mutation	173.85	12.79	79	86590	1082	29864727
B-cell lymphoma recurrent	171.42	12.79	66	86603	577	29865232
Dizziness	169.17	12.79	189	86480	194720	29671089
Cytopenia	168.28	12.79	160	86509	8096	29857713
Arthralgia	167.88	12.79	92	86577	135699	29730110
Fatigue	167.06	12.79	432	86237	320241	29545568
Rash	160.12	12.79	192	86477	191697	29674112
Disease progression	156.81	12.79	548	86121	79326	29786483
Post transplant lymphoproliferative disorder	152.55	12.79	125	86544	5181	29860628
Hypertriglyceridaemia	148.30	12.79	148	86521	7950	29857859
Cardiotoxicity	146.18	12.79	113	86556	4301	29861508
Hyperbilirubinaemia	146.15	12.79	211	86458	16731	29849078
White blood cell count decreased	140.48	12.79	547	86122	83400	29782409
Hypogammaglobulinaemia	135.03	12.79	116	86553	5136	29860673
Pain	134.37	12.79	182	86487	172459	29693350
Mantle cell lymphoma recurrent	133.03	12.79	49	86620	374	29865435
Neoplasm recurrence	133.02	12.79	77	86592	1790	29864019
Leukoencephalopathy	131.55	12.79	102	86567	3900	29861909
Muscle spasms	129.96	12.79	17	86652	64821	29800988
Neurotoxicity	129.86	12.79	175	86494	13007	29852802
Dyspnoea	129.41	12.79	512	86157	332783	29533026
Insomnia	127.82	12.79	55	86614	93281	29772528
Anxiety	122.99	12.79	53	86616	89818	29775991
Rhabdomyolysis	121.99	12.79	19	86650	63561	29802248
Overdose	121.50	12.79	46	86623	84291	29781518
Aspergillus infection	118.45	12.79	147	86522	10067	29855742
Joint swelling	117.84	12.79	4	86665	46942	29818867
Peripheral swelling	115.49	12.79	19	86650	61055	29804754
Malaise	111.68	12.79	195	86474	166767	29699042
Lymphopenia	110.70	12.79	162	86507	13001	29852808
Depression	109.20	12.79	63	86606	90374	29775435
Polyneuropathy	108.98	12.79	152	86517	11671	29854138
Pruritus	108.70	12.79	109	86560	118095	29747714
Osteonecrosis	108.35	12.79	179	86490	15956	29849853
Epstein-Barr virus infection	107.32	12.79	114	86555	6592	29859217
Bacteraemia	106.35	12.79	174	86495	15386	29850423
Lymphadenopathy	105.52	12.79	224	86445	24152	29841657
Hepatic failure	102.95	12.79	272	86397	33771	29832038
Malignant neoplasm progression	102.72	12.79	448	86221	71839	29793970
Rheumatoid arthritis	101.70	12.79	4	86665	41193	29824616
Central nervous system lymphoma	101.43	12.79	50	86619	830	29864979
Myelopathy	97.18	12.79	64	86605	1883	29863926
Venoocclusive disease	93.92	12.79	70	86599	2520	29863289
Disease recurrence	93.61	12.79	156	86513	14005	29851804
Weight increased	93.59	12.79	50	86619	74863	29790946
Myalgia	93.13	12.79	53	86616	76614	29789195
Coronary artery disease	92.80	12.79	16	86653	49696	29816113
Cerebrovascular accident	92.72	12.79	64	86605	83413	29782396
Feeling abnormal	92.28	12.79	25	86644	56731	29809078
Stomatitis	92.27	12.79	277	86392	37002	29828807
Therapy partial responder	91.80	12.79	80	86589	3611	29862198
Aplasia	91.46	12.79	83	86586	3954	29861855
Suicidal ideation	90.91	12.79	3	86666	36111	29829698
Sweat gland tumour	90.02	12.79	37	86632	390	29865419
Suicide attempt	89.13	12.79	4	86665	36693	29829116
Cardiac failure congestive	88.20	12.79	69	86600	84338	29781471
Candida infection	86.90	12.79	158	86511	15204	29850605
Somnolence	85.80	12.79	92	86577	96671	29769138
Inappropriate schedule of product administration	85.70	12.79	8	86661	39720	29826089
B-cell lymphoma	85.49	12.79	84	86585	4426	29861383
Hallucination	84.83	12.79	19	86650	49040	29816769
Ileus paralytic	83.35	12.79	92	86577	5556	29860253
Psoriasis	83.14	12.79	12	86657	42494	29823315
Blood fibrinogen decreased	81.86	12.79	45	86624	944	29864865
Cytomegalovirus infection	81.82	12.79	199	86470	23475	29842334
Hospitalisation	81.13	12.79	15	86654	44304	29821505
Herpes simplex	80.65	12.79	81	86588	4383	29861426
Platelet count decreased	77.96	12.79	550	86119	105579	29760230
Intentional product misuse	77.46	12.79	6	86663	34661	29831148
Nasopharyngitis	76.90	12.79	37	86632	58812	29806997
Infection	76.18	12.79	435	86234	77639	29788170
Drug resistance	73.63	12.79	173	86496	19960	29845849
Colitis	73.44	12.79	226	86443	30594	29835215
Cytokine release syndrome	73.24	12.79	115	86554	9818	29855991
Chronic obstructive pulmonary disease	71.88	12.79	22	86647	46104	29819705
Multiple organ dysfunction syndrome	70.18	12.79	366	86303	63121	29802688
Chest pain	69.32	12.79	148	86521	117479	29748330
Bronchopulmonary aspergillosis	69.05	12.79	126	86543	12158	29853651
Aggression	68.61	12.79	12	86657	36895	29828914
Blood glucose increased	68.54	12.79	47	86622	61483	29804326
Cerebral venous thrombosis	68.51	12.79	34	86635	573	29865236
Blood creatine phosphokinase increased	68.17	12.79	21	86648	43827	29821982
Drug interaction	67.76	12.79	322	86347	199246	29666563
Adenovirus infection	67.31	12.79	72	86597	4196	29861613
Neutropenic colitis	67.19	12.79	54	86615	2176	29863633
Hyperhidrosis	66.17	12.79	58	86611	67032	29798777
West Nile viral infection	65.87	12.79	33	86636	568	29865241
Diarrhoea	65.49	12.79	635	86034	333468	29532341
Cytogenetic abnormality	65.37	12.79	36	86633	758	29865051
Tremor	65.30	12.79	73	86596	75290	29790519
Haemophagocytic lymphohistiocytosis	63.56	12.79	107	86562	9684	29856125
Confusional state	62.96	12.79	191	86478	134643	29731166
Lymphoma	62.27	12.79	108	86561	10013	29855796
Blood culture positive	62.24	12.79	74	86595	4845	29860964
Bacterial sepsis	62.16	12.79	74	86595	4852	29860957
Adenoviral hepatitis	61.85	12.79	22	86647	150	29865659
Mucormycosis	61.37	12.79	76	86593	5192	29860617
Epstein-Barr virus associated lymphoproliferative disorder	61.09	12.79	46	86623	1682	29864127
Blood pressure increased	60.88	12.79	71	86598	71857	29793952
Asthma	60.58	12.79	15	86654	36159	29829650
Escherichia sepsis	60.57	12.79	66	86603	3928	29861881
Oesophageal stenosis	60.13	12.79	44	86625	1539	29864270
Agranulocytosis	60.01	12.79	169	86500	21773	29844036
Superior sagittal sinus thrombosis	58.94	12.79	25	86644	287	29865522
Acute lymphocytic leukaemia refractory	57.86	12.79	19	86650	98	29865711
Fungal infection	57.71	12.79	124	86545	13476	29852333
Stem cell transplant	56.68	12.79	48	86621	2083	29863726
Antithrombin III decreased	56.45	12.79	26	86643	368	29865441
Systemic mycosis	55.95	12.79	38	86631	1178	29864631
Gastritis bacterial	55.94	12.79	21	86648	170	29865639
Hepatotoxicity	55.87	12.79	146	86523	17999	29847810
Memory impairment	55.67	12.79	19	86650	37155	29828654
Staphylococcal sepsis	55.44	12.79	99	86570	9392	29856417
Incorrect dose administered	55.32	12.79	12	86657	31674	29834135
Malignant transformation	55.07	12.79	31	86638	682	29865127
Injection site pain	53.90	12.79	11	86658	30299	29835510
Asthenia	53.88	12.79	397	86272	220893	29644916
Oedema peripheral	53.73	12.79	144	86525	105688	29760121
Coombs positive haemolytic anaemia	53.04	12.79	31	86638	734	29865075
Headache	52.99	12.79	310	86359	181996	29683813
Hypoglycaemia	52.82	12.79	42	86627	50939	29814870
Plasmablastic lymphoma	52.22	12.79	22	86647	248	29865561
Leukaemia recurrent	51.77	12.79	40	86629	1521	29864288
Pain in extremity	51.53	12.79	156	86513	110065	29755744
Inappropriate antidiuretic hormone secretion	50.62	12.79	106	86563	11316	29854493
Gait disturbance	49.30	12.79	88	86581	74689	29791120
Chest discomfort	48.99	12.79	36	86633	45444	29820365
Pseudomonas infection	48.47	12.79	99	86570	10383	29855426
Back pain	48.10	12.79	145	86524	102451	29763358
Loss of consciousness	47.46	12.79	99	86570	79276	29786533
Strongyloidiasis	46.91	12.79	45	86624	2301	29863508
Aspiration bone marrow abnormal	46.86	12.79	16	86653	95	29865714
Stress	46.66	12.79	3	86666	20232	29845577
Drug hypersensitivity	46.65	12.79	79	86590	68440	29797369
Hepatosplenic candidiasis	46.42	12.79	19	86650	198	29865611
Cerebral venous sinus thrombosis	46.18	12.79	21	86648	288	29865521
Pneumonitis	45.92	12.79	179	86490	27275	29838534
Pulmonary vascular disorder	45.63	12.79	22	86647	347	29865462
Peripheral motor neuropathy	45.42	12.79	38	86631	1621	29864188
Myelitis transverse	45.42	12.79	31	86638	969	29864840
Intussusception	45.41	12.79	25	86644	526	29865283
Injury	45.24	12.79	5	86664	21726	29844083
Arthropathy	45.16	12.79	4	86665	20723	29845086
Gastrointestinal toxicity	44.93	12.79	41	86628	1967	29863842
JC virus infection	44.92	12.79	39	86630	1751	29864058
Cystitis haemorrhagic	44.79	12.79	62	86607	4725	29861084
Abdominal discomfort	44.78	12.79	45	86624	48746	29817063
Musculoskeletal stiffness	44.71	12.79	24	86645	35857	29829952
Device related infection	44.53	12.79	129	86540	16886	29848923
Syncope	42.72	12.79	116	86553	84787	29781022
Glioma	42.44	12.79	20	86649	299	29865510
Bone marrow necrosis	42.36	12.79	16	86653	132	29865677
Pleural effusion	42.20	12.79	362	86307	73704	29792105
Hepatomegaly	41.93	12.79	91	86578	9956	29855853
Balance disorder	41.81	12.79	27	86642	36466	29829343
Respiratory failure	41.68	12.79	460	86209	100182	29765627
Wrong technique in product usage process	41.59	12.79	19	86650	31136	29834673
Hyperkalaemia	41.45	12.79	80	86589	65930	29799879
Therapy non-responder	41.37	12.79	182	86487	29271	29836538
Anaemia	41.23	12.79	837	85832	207155	29658654
Enterovirus infection	41.22	12.79	24	86645	564	29865245
Nausea	40.97	12.79	609	86060	296348	29569461
Peripheral T-cell lymphoma unspecified	40.94	12.79	23	86646	504	29865305
Recurrent cancer	40.90	12.79	31	86638	1145	29864664
Cardiomyopathy	40.78	12.79	116	86553	15027	29850782
Lung infiltration	40.67	12.79	103	86566	12456	29853353
Lymphadenitis	40.22	12.79	36	86633	1684	29864125
Loss of personal independence in daily activities	40.03	12.79	7	86662	21528	29844281
Product quality issue	39.90	12.79	4	86665	18770	29847039
Viral haemorrhagic cystitis	39.84	12.79	27	86642	834	29864975
Central nervous system leukaemia	39.64	12.79	18	86651	246	29865563
Systemic candida	39.03	12.79	44	86625	2720	29863089
Primitive neuroectodermal tumour	38.68	12.79	13	86656	73	29865736
Unevaluable event	38.53	12.79	22	86647	31763	29834046
Refractory anaemia with an excess of blasts	38.34	12.79	20	86649	376	29865433
Congenital cardiovascular anomaly	38.08	12.79	16	86653	179	29865630
Coagulopathy	38.08	12.79	129	86540	18358	29847451
Ejection fraction decreased	37.75	12.79	113	86556	15062	29850747
Sleep disorder	37.55	12.79	12	86657	24467	29841342
Serotonin syndrome	37.54	12.79	4	86665	17887	29847922
Encephalitis enteroviral	37.28	12.79	15	86654	149	29865660
Cardio-respiratory arrest	37.26	12.79	68	86601	57238	29808571
Lymphoma transformation	36.84	12.79	15	86654	154	29865655
International normalised ratio increased	36.36	12.79	51	86618	47688	29818121
Peripheral sensory neuropathy	36.34	12.79	63	86606	5838	29859971
Haemoglobin abnormal	36.22	12.79	45	86624	3084	29862725
Sedation	36.11	12.79	3	86666	16370	29849439
Mobility decreased	36.06	12.79	15	86654	25984	29839825
Treatment noncompliance	35.96	12.79	14	86655	25239	29840570
Neuroleptic malignant syndrome	35.90	12.79	3	86666	16292	29849517
Weight decreased	35.61	12.79	273	86396	150648	29715161
Chronic lymphocytic leukaemia refractory	35.55	12.79	13	86656	97	29865712
Haemolysis	35.47	12.79	70	86599	7161	29858648
Fluid retention	35.36	12.79	14	86655	24984	29840825
Depressed mood	35.24	12.79	4	86665	17025	29848784
Pneumocystis jirovecii infection	35.17	12.79	30	86639	1315	29864494
Acute myelomonocytic leukaemia	34.98	12.79	14	86655	137	29865672
Nephrolithiasis	34.92	12.79	14	86655	24796	29841013
T-cell type acute leukaemia	34.92	12.79	15	86654	178	29865631
Minimal residual disease	34.89	12.79	16	86653	224	29865585
Epstein-Barr virus associated lymphoma	34.77	12.79	21	86648	529	29865280
Contusion	34.68	12.79	24	86645	31256	29834553
Pulmonary toxicity	34.29	12.79	53	86616	4463	29861346
Blood stem cell transplant failure	34.25	12.79	19	86650	406	29865403
Klebsiella infection	34.18	12.79	67	86602	6820	29858989
Toxicity to various agents	34.05	12.79	338	86331	176845	29688964
Escherichia bacteraemia	34.02	12.79	42	86627	2860	29862949
Wheezing	33.95	12.79	24	86645	30914	29834895
Gene mutation	33.89	12.79	24	86645	797	29865012
Escherichia infection	33.86	12.79	64	86605	6341	29859468
B-cell lymphoma refractory	33.83	12.79	13	86656	113	29865696
Body height below normal	33.79	12.79	16	86653	242	29865567
Abnormal behaviour	33.63	12.79	16	86653	25607	29840202
Atrial fibrillation	33.46	12.79	180	86489	107944	29757865
Bradycardia	33.35	12.79	89	86580	65437	29800372
Abdominal pain upper	33.34	12.79	83	86586	62468	29803341
Adverse event	33.32	12.79	3	86666	15338	29850471
Nervous system disorder	33.16	12.79	98	86571	12971	29852838
End stage renal disease	32.94	12.79	69	86600	7366	29858443
Electrocardiogram QT prolonged	32.94	12.79	33	86636	35802	29830007
Rhabdomyosarcoma recurrent	32.87	12.79	12	86657	89	29865720
Agitation	32.69	12.79	67	86602	54006	29811803
Xanthogranuloma	32.50	12.79	10	86659	40	29865769
Juvenile melanoma benign	32.40	12.79	11	86658	64	29865745
Respiratory distress	32.30	12.79	184	86485	32788	29833021
Pneumonia aspiration	32.27	12.79	37	86632	37743	29828066
Neuroblastoma	32.15	12.79	15	86654	219	29865590
Pulmonary arteriopathy	32.12	12.79	11	86658	66	29865743
Intestinal perforation	32.01	12.79	74	86595	8445	29857364
Palpitations	31.92	12.79	30	86639	33543	29832266
Cardiac arrest	31.91	12.79	149	86520	92701	29773108
Blood pressure fluctuation	31.86	12.79	6	86663	17497	29848312
Hepatosplenomegaly	31.76	12.79	46	86623	3655	29862154
Pneumatosis intestinalis	31.64	12.79	39	86630	2651	29863158
Epstein-Barr viraemia	31.53	12.79	24	86645	892	29864917
Hereditary motor and sensory neuropathy	31.49	12.79	8	86661	12	29865797
Influenza	31.45	12.79	48	86621	43350	29822459
Drug reaction with eosinophilia and systemic symptoms	31.39	12.79	22	86647	28466	29837343
Acute promyelocytic leukaemia	31.37	12.79	20	86649	556	29865253
Ganglioneuroblastoma	31.24	12.79	9	86660	27	29865782
Clostridium test positive	31.22	12.79	34	86635	2022	29863787
Adverse drug reaction	31.08	12.79	14	86655	23131	29842678
Dry skin	31.07	12.79	13	86656	22441	29843368
Acute monocytic leukaemia	31.03	12.79	17	86652	354	29865455
T-cell lymphoma	30.82	12.79	24	86645	923	29864886
Infection reactivation	30.71	12.79	24	86645	928	29864881
Amnesia	30.69	12.79	16	86653	24305	29841504
Hepatic infection fungal	30.43	12.79	13	86656	152	29865657
Disseminated intravascular coagulation	30.37	12.79	136	86533	22035	29843774
Neurofibrosarcoma	30.30	12.79	9	86660	31	29865778
Autoimmune lymphoproliferative syndrome	30.28	12.79	13	86656	154	29865655
Chronic kidney disease	30.26	12.79	39	86630	37799	29828010
Staphylococcal bacteraemia	30.21	12.79	63	86606	6705	29859104
Subdural hygroma	29.88	12.79	16	86653	318	29865491
Human rhinovirus test positive	29.77	12.79	13	86656	161	29865648
Mantle cell lymphoma	29.76	12.79	29	86640	1512	29864297
Delayed puberty	29.42	12.79	13	86656	166	29865643
Acute hepatic failure	29.35	12.79	88	86581	11739	29854070
Transformation to acute myeloid leukaemia	29.28	12.79	20	86649	626	29865183
Injection site erythema	29.26	12.79	3	86666	13831	29851978
Small intestinal perforation	29.18	12.79	30	86639	1669	29864140
Anal inflammation	29.09	12.79	16	86653	336	29865473
Hepatocellular injury	28.92	12.79	148	86521	25323	29840486
Multiple-drug resistance	28.89	12.79	39	86630	2902	29862907
Pneumonia viral	28.61	12.79	37	86632	2640	29863169
Plasma cell myeloma	28.44	12.79	71	86598	53391	29812418
Transient ischaemic attack	28.38	12.79	19	86650	25181	29840628
Pseudomonal sepsis	28.28	12.79	39	86630	2961	29862848
Cerebral thrombosis	28.23	12.79	22	86647	847	29864962
Traumatic lung injury	28.17	12.79	25	86644	1156	29864653
Bone marrow infiltration	28.10	12.79	11	86658	101	29865708
Stevens-Johnson syndrome	28.02	12.79	8	86661	17548	29848261
Left ventricular dysfunction	27.85	12.79	71	86598	8620	29857189
Hypersensitivity	27.78	12.79	73	86596	53955	29811854
Blood creatinine increased	27.78	12.79	153	86516	91222	29774587
Decreased appetite	27.53	12.79	289	86380	149621	29716188
Myocardial ischaemia	27.44	12.79	8	86661	17309	29848500
High-grade B-cell lymphoma	27.10	12.79	12	86657	154	29865655
Ewing's sarcoma	26.83	12.79	8	86661	28	29865781
Optic glioma	26.83	12.79	8	86661	28	29865781
Intestinal pseudo-obstruction	26.82	12.79	24	86645	1122	29864687
Hot flush	26.79	12.79	5	86664	14675	29851134
Musculoskeletal pain	26.75	12.79	30	86639	30910	29834899
Encephalopathy	26.64	12.79	172	86497	32033	29833776
Haematochezia	26.62	12.79	36	86633	34186	29831623
Gastrosplenic fistula	26.62	12.79	8	86661	29	29865780
Cardiac disorder	26.23	12.79	47	86622	39846	29825963
Gastrooesophageal reflux disease	26.04	12.79	33	86636	32222	29833587
Diffuse large B-cell lymphoma stage IV	25.88	12.79	13	86656	225	29865584
Herpes simplex encephalitis	25.80	12.79	14	86655	286	29865523
Ascites	25.64	12.79	185	86484	35736	29830073
Acute lung injury	25.55	12.79	23	86646	1084	29864725
Lymphocytosis	25.52	12.79	30	86639	1940	29863869
Rhabdomyosarcoma	25.48	12.79	9	86660	60	29865749
Diffuse large B-cell lymphoma stage III	25.48	12.79	9	86660	60	29865749
Chronic lymphocytic leukaemia	25.41	12.79	47	86622	4581	29861228
Clostridium difficile colitis	25.34	12.79	88	86581	12680	29853129
Bone marrow disorder	25.33	12.79	26	86643	1444	29864365
Device related thrombosis	25.25	12.79	20	86649	789	29865020
Vision blurred	25.11	12.79	52	86617	41764	29824045
Dysgeusia	24.97	12.79	21	86648	24780	29841029
Blood glucose decreased	24.80	12.79	4	86665	13049	29852760
Heart rate decreased	24.78	12.79	15	86654	20979	29844830
Varicella zoster virus infection	24.75	12.79	24	86645	1244	29864565
Thymus enlargement	24.74	12.79	9	86660	66	29865743
Oesophageal candidiasis	24.69	12.79	44	86625	4166	29861643
Pneumoperitoneum	24.69	12.79	27	86642	1613	29864196
Sleep apnoea syndrome	24.58	12.79	9	86660	16848	29848961
Medulloblastoma recurrent	24.51	12.79	9	86660	68	29865741
Prostatic specific antigen increased	24.39	12.79	3	86666	12001	29853808
Delusion	24.35	12.79	3	86666	11986	29853823
Pneumonia fungal	24.11	12.79	51	86618	5482	29860327
Intestinal atresia	24.07	12.79	9	86660	72	29865737
Therapy cessation	23.97	12.79	7	86662	15130	29850679
Rib fracture	23.94	12.79	4	86665	12716	29853093
Azoospermia	23.85	12.79	15	86654	407	29865402
Hepatic candidiasis	23.64	12.79	8	86661	46	29865763
Metastases to bone marrow	23.64	12.79	16	86653	493	29865316
Liver function test abnormal	23.63	12.79	33	86636	30917	29834892
BK virus infection	23.56	12.79	44	86625	4320	29861489
Interstitial lung disease	23.47	12.79	272	86397	59925	29805884
Cerebral aspergillosis	23.36	12.79	24	86645	1334	29864475
Delirium	23.17	12.79	52	86617	40579	29825230
Influenza like illness	23.05	12.79	24	86645	25581	29840228
Vertigo	23.00	12.79	19	86650	22616	29843193
Neutropenic infection	22.98	12.79	21	86648	1009	29864800
Flushing	22.96	12.79	31	86638	29461	29836348
Refractory cancer	22.96	12.79	10	86659	123	29865686
Congenital herpes simplex infection	22.95	12.79	8	86661	51	29865758
Faeces discoloured	22.93	12.79	6	86663	13940	29851869
Mucosal infection	22.80	12.79	12	86657	230	29865579
Ameloblastoma	22.77	12.79	9	86660	85	29865724
Alanine aminotransferase increased	22.76	12.79	321	86348	73955	29791854
Gastrointestinal necrosis	22.76	12.79	37	86632	3252	29862557
Cellulitis gangrenous	22.67	12.79	11	86658	176	29865633
Blastic plasmacytoid dendritic cell neoplasia	22.67	12.79	9	86660	86	29865723
Blindness cortical	22.62	12.79	13	86656	298	29865511
Splenic lesion	22.54	12.79	10	86659	129	29865680
Clostridium difficile infection	22.51	12.79	98	86571	15685	29850124
Enterocolitis infectious	22.50	12.79	22	86647	1152	29864657
Osteosarcoma	22.18	12.79	11	86658	185	29865624
Blood pressure systolic increased	22.14	12.79	8	86661	15102	29850707
Gallbladder oedema	22.08	12.79	11	86658	187	29865622
Burning sensation	22.06	12.79	10	86659	16464	29849345
Respiratory tract infection fungal	22.01	12.79	17	86652	646	29865163
Psoriatic arthropathy	22.01	12.79	9	86660	15752	29850057
Renal salt-wasting syndrome	22	12.79	10	86659	137	29865672
Psychotic disorder	21.93	12.79	18	86651	21497	29844312
Stomatococcal infection	21.87	12.79	10	86659	139	29865670
Morphoea	21.74	12.79	10	86659	141	29865668
Ileus	21.74	12.79	96	86573	15459	29850350
Restlessness	21.71	12.79	20	86649	22579	29843230
Acute kidney injury	21.71	12.79	615	86054	273227	29592582
Genotoxicity	21.66	12.79	7	86662	34	29865775
Rash pruritic	21.66	12.79	20	86649	22552	29843257
Granulocyte count decreased	21.65	12.79	17	86652	662	29865147
Central nervous system fungal infection	21.61	12.79	12	86657	257	29865552
Non-Hodgkin's lymphoma	21.59	12.79	26	86643	1725	29864084
Respiratory arrest	21.54	12.79	32	86637	29226	29836583
Dyspepsia	21.54	12.79	34	86635	30295	29835514
Positron emission tomogram abnormal	21.40	12.79	9	86660	101	29865708
Hepatitis	21.40	12.79	124	86545	22232	29843577
Rectal haemorrhage	21.36	12.79	43	86626	34896	29830913
Arteriosclerosis	21.31	12.79	3	86666	10830	29854979
Angioedema	21.29	12.79	42	86627	34342	29831467
Paraplegia	21.29	12.79	32	86637	2629	29863180
Pseudomonas test positive	21.29	12.79	20	86649	996	29864813
Erectile dysfunction	21.27	12.79	13	86656	18089	29847720
Focal nodular hyperplasia	21.25	12.79	10	86659	149	29865660
Hallucination, visual	21.24	12.79	10	86659	16103	29849706
Lactic acidosis	21.22	12.79	36	86633	31177	29834632
Molluscum contagiosum	21.16	12.79	12	86657	268	29865541
Metastases to retroperitoneum	21.08	12.79	11	86658	207	29865602
Acute erythroid leukaemia	21.07	12.79	10	86659	152	29865657
Facial paresis	21.01	12.79	33	86636	2817	29862992
Splenic marginal zone lymphoma	20.87	12.79	7	86662	39	29865770
Hepatic amoebiasis	20.87	12.79	8	86661	69	29865740
Drug clearance decreased	20.86	12.79	22	86647	1261	29864548
Erythema	20.73	12.79	135	86534	77316	29788493
Extravasation	20.69	12.79	26	86643	1802	29864007
Disorientation	20.67	12.79	37	86632	31381	29834428
B-cell type acute leukaemia	20.65	12.79	12	86657	281	29865528
Escherichia test positive	20.62	12.79	20	86649	1037	29864772
Immunosuppression	20.61	12.79	46	86623	5129	29860680
Labelled drug-drug interaction medication error	20.54	12.79	3	86666	10535	29855274
Dermatitis diaper	20.54	12.79	12	86657	284	29865525
Peritonitis bacterial	20.50	12.79	4	86665	11374	29854435
Personality change due to a general medical condition	20.44	12.79	7	86662	42	29865767
Suspected product quality issue	20.39	12.79	10	86659	164	29865645
Hepatitis D	20.30	12.79	7	86662	43	29865766
Haemorrhage	20.25	12.79	67	86602	46012	29819797
Haematopoietic stem cell mobilisation	20.12	12.79	10	86659	169	29865640
Glioblastoma multiforme	20.05	12.79	18	86651	845	29864964
Cerebral toxoplasmosis	20.05	12.79	23	86646	1449	29864360
Sphingomonas paucimobilis infection	20.03	12.79	7	86662	45	29865764
Parainfluenzae virus infection	19.98	12.79	27	86642	2011	29863798
Anger	19.84	12.79	4	86665	11116	29854693
Retinal haemorrhage	19.84	12.79	43	86626	4700	29861109
Muscle rigidity	19.82	12.79	3	86666	10258	29855551
Periorbital infection	19.76	12.79	9	86660	124	29865685
Eczema	19.72	12.79	7	86662	13362	29852447
Burkitt's lymphoma	19.71	12.79	10	86659	177	29865632
Arthritis	19.66	12.79	25	86644	24376	29841433
Diaphragm muscle weakness	19.66	12.79	8	86661	82	29865727
Anaplastic large-cell lymphoma	19.66	12.79	10	86659	178	29865631
Disturbance in attention	19.63	12.79	21	86648	22108	29843701
Disseminated cryptococcosis	19.51	12.79	19	86650	990	29864819
Renal impairment	19.49	12.79	153	86516	84031	29781778
Dehydration	19.23	12.79	247	86422	123292	29742517
Chronic myeloid leukaemia	19.22	12.79	30	86639	2547	29863262
Blood HIV RNULL increased	19.08	12.79	22	86647	1394	29864415
Stomatitis necrotising	19.00	12.79	8	86661	90	29865719
Peripheral sensorimotor neuropathy	18.94	12.79	21	86648	1274	29864535
Head injury	18.94	12.79	13	86656	17007	29848802
Localised infection	18.93	12.79	8	86661	13729	29852080
Bone sarcoma	18.92	12.79	8	86661	91	29865718
Vocal cord paralysis	18.90	12.79	17	86652	800	29865009
Metastases to spleen	18.90	12.79	12	86657	331	29865478
Abdominal neoplasm	18.80	12.79	10	86659	196	29865613
Gastrointestinal haemorrhage	18.70	12.79	153	86516	83293	29782516
Fungal sepsis	18.68	12.79	16	86653	705	29865104
Transaminases increased	18.62	12.79	124	86545	23333	29842476
Marginal zone lymphoma recurrent	18.59	12.79	6	86663	29	29865780
Granulocytopenia neonatal	18.59	12.79	6	86663	29	29865780
Metastases to muscle	18.48	12.79	10	86659	203	29865606
Superior vena cava syndrome	18.45	12.79	13	86656	428	29865381
Basal cell naevus syndrome	18.43	12.79	6	86663	30	29865779
Bacillus test positive	18.43	12.79	6	86663	30	29865779
Skin exfoliation	18.40	12.79	24	86645	23148	29842661
Platelet count abnormal	18.37	12.79	28	86641	2329	29863480
Hypersomnia	18.35	12.79	5	86664	11311	29854498
Vascular access complication	18.35	12.79	10	86659	206	29865603
Candida endophthalmitis	18.33	12.79	8	86661	99	29865710
Diabetes mellitus inadequate control	18.29	12.79	7	86662	12755	29853054
Phlebitis infective	18.28	12.79	9	86660	149	29865660
Enterovesical fistula	18.25	12.79	15	86654	624	29865185
Candida sepsis	18.15	12.79	19	86650	1080	29864729
Gastric stenosis	18.11	12.79	6	86663	32	29865777
5q minus syndrome	18.01	12.79	9	86660	154	29865655
Infusion site discolouration	17.91	12.79	8	86661	105	29865704
Orthostatic hypotension	17.88	12.79	26	86643	23953	29841856
Protein C decreased	17.87	12.79	5	86664	13	29865796
Skin toxicity	17.84	12.79	33	86636	3216	29862593
Platelet transfusion	17.83	12.79	18	86651	980	29864829
Bronchitis	17.81	12.79	56	86613	39069	29826740
Cutaneous T-cell lymphoma recurrent	17.81	12.79	6	86663	34	29865775
Gastrointestinal inflammation	17.76	12.79	31	86638	2888	29862921
Swollen tongue	17.68	12.79	8	86661	13184	29852625
Acinetobacter infection	17.65	12.79	18	86651	992	29864817
Sopor	17.56	12.79	5	86664	10986	29854823
Cerebral salt-wasting syndrome	17.52	12.79	6	86663	36	29865773
Chromosome analysis abnormal	17.51	12.79	8	86661	111	29865698
Enterococcal infection	17.48	12.79	58	86611	8166	29857643
Adenocarcinoma gastric	17.42	12.79	19	86650	1132	29864677
Accidental exposure to product	17.31	12.79	4	86665	10111	29855698
Pulmonary sarcoidosis	17.25	12.79	14	86655	572	29865237
Vasogenic cerebral oedema	17.25	12.79	13	86656	476	29865333
Pneumaturia	17.25	12.79	6	86663	38	29865771
Sinusitis bacterial	17.25	12.79	11	86658	306	29865503
Exposure during pregnancy	17.23	12.79	3	86666	9258	29856551
B-lymphocyte count decreased	17.22	12.79	13	86656	477	29865332
Renal tubular disorder	17.20	12.79	42	86627	4964	29860845
Hepatitis viral	17.15	12.79	13	86656	480	29865329
Proteinuria	17.09	12.79	13	86656	16132	29849677
Cranial nerve disorder	17.06	12.79	12	86657	394	29865415
Cavernous sinus thrombosis	17.01	12.79	8	86661	119	29865690
Bacterial infection	17.00	12.79	77	86592	12533	29853276
Protein S decreased	16.98	12.79	6	86663	40	29865769
Taeniasis	16.85	12.79	7	86662	76	29865733
Central nervous system neoplasm	16.73	12.79	6	86663	42	29865767
Lymphoplasmacytoid lymphoma/immunocytoma	16.73	12.79	6	86663	42	29865767
Streptococcal infection	16.71	12.79	40	86629	4668	29861141
Therapy responder	16.71	12.79	9	86660	181	29865628
Limb discomfort	16.69	12.79	3	86666	9047	29856762
Ocular hyperaemia	16.67	12.79	3	86666	9040	29856769
Iron deficiency anaemia	16.62	12.79	3	86666	9021	29856788
Plasma cell myeloma refractory	16.61	12.79	6	86663	43	29865766
Precursor T-lymphoblastic lymphoma/leukaemia	16.53	12.79	7	86662	80	29865729
Hallucination, auditory	16.50	12.79	4	86665	9785	29856024
Peripheral T-cell lymphoma unspecified stage III	16.50	12.79	6	86663	44	29865765
Adult T-cell lymphoma/leukaemia	16.41	12.79	10	86659	256	29865553
Hepatitis B DNULL increased	16.39	12.79	13	86656	514	29865295
Diffuse large B-cell lymphoma stage II	16.27	12.79	6	86663	46	29865763
Central nervous system enteroviral infection	16.27	12.79	6	86663	46	29865763
Drug eruption	16.26	12.79	16	86653	17510	29848299
Helicobacter sepsis	16.25	12.79	5	86664	20	29865789
Premature ageing	16.23	12.79	7	86662	84	29865725
Non-alcoholic steatohepatitis	16.05	12.79	15	86654	742	29865067
T-cell lymphoma recurrent	16.05	12.79	6	86663	48	29865761
Ototoxicity	16.03	12.79	20	86649	1376	29864433
Paresis	16	12.79	23	86646	1815	29863994
Injection site swelling	16.00	12.79	3	86666	8777	29857032
Subclavian vein thrombosis	15.95	12.79	16	86653	864	29864945
Heart rate increased	15.87	12.79	58	86611	38663	29827146
Dry mouth	15.86	12.79	26	86643	22824	29842985
Lymphoproliferative disorder	15.84	12.79	26	86643	2304	29863505
Blood lactate dehydrogenase increased	15.81	12.79	108	86561	20493	29845316
Gastrointestinal injury	15.81	12.79	11	86658	355	29865454
Klebsiella sepsis	15.71	12.79	22	86647	1695	29864114
Rectal adenoma	15.69	12.79	5	86664	23	29865786
White blood cell count abnormal	15.66	12.79	28	86641	2658	29863151
Pancreatitis	15.63	12.79	168	86501	36322	29829487
Metapneumovirus infection	15.59	12.79	13	86656	552	29865257
Diabetic ketoacidosis	15.53	12.79	14	86655	15972	29849837
Accidental overdose	15.49	12.79	18	86651	18257	29847552
Prescribed overdose	15.44	12.79	3	86666	8558	29857251
Embolism	15.40	12.79	50	86619	6959	29858850
Angiodysplasia	15.40	12.79	12	86657	462	29865347
Fibrosarcoma	15.36	12.79	5	86664	25	29865784
Refractory cytopenia with multilineage dysplasia	15.35	12.79	8	86661	150	29865659
Humoral immune defect	15.33	12.79	6	86663	55	29865754
Postural tremor	15.31	12.79	10	86659	290	29865519
Irritability	15.29	12.79	27	86642	23023	29842786
Lymphocytic leukaemia	15.26	12.79	8	86661	152	29865657
Injection site reaction	15.26	12.79	6	86663	10754	29855055
Klebsiella bacteraemia	15.22	12.79	17	86652	1040	29864769
Hyperpyrexia	15.20	12.79	27	86642	2550	29863259
Blood cholesterol increased	15.17	12.79	16	86653	16954	29848855
Skin discolouration	15.14	12.79	14	86655	15780	29850029
Optic nerve disorder	15.14	12.79	13	86656	575	29865234
Retroperitoneal lymphadenopathy	15.11	12.79	14	86655	685	29865124
Extrapyramidal disorder	15.10	12.79	6	86663	10687	29855122
Lower respiratory tract infection fungal	15.08	12.79	13	86656	578	29865231
Leukaemia	15.08	12.79	31	86638	3266	29862543
Vocal cord paresis	15.08	12.79	7	86662	101	29865708
Urinary retention	15.06	12.79	47	86622	32870	29832939
Transplant rejection	15.06	12.79	4	86665	9202	29856607
Ganglioneuroma	15.02	12.79	4	86665	8	29865801
Peroneal nerve palsy	14.89	12.79	26	86643	2423	29863386
Pneumonia cytomegaloviral	14.86	12.79	28	86641	2768	29863041
Mantle cell lymphoma stage IV	14.79	12.79	6	86663	61	29865748
Extramedullary haemopoiesis	14.79	12.79	6	86663	61	29865748
Neutrophil percentage decreased	14.78	12.79	11	86658	395	29865414
Congenital hepatobiliary anomaly	14.74	12.79	5	86664	29	29865780
Cytomegalovirus enterocolitis	14.73	12.79	15	86654	825	29864984
Urticaria	14.70	12.79	95	86574	54511	29811298
Neutrophil count abnormal	14.69	12.79	19	86650	1356	29864453
Swelling	14.67	12.79	54	86615	35921	29829888
Retinoblastoma	14.60	12.79	5	86664	30	29865779
Psychomotor hyperactivity	14.59	12.79	3	86666	8221	29857588
Salivary gland atrophy	14.55	12.79	3	86666	0	29865809
Alveolar rhabdomyosarcoma	14.55	12.79	3	86666	0	29865809
Anal candidiasis	14.55	12.79	3	86666	0	29865809
Febrile infection	14.54	12.79	21	86648	1664	29864145
Blood bilirubin increased	14.48	12.79	166	86503	36470	29829339
Paternal exposure timing unspecified	14.46	12.79	5	86664	31	29865778
Lewis-Sumner syndrome	14.46	12.79	5	86664	31	29865778
Muscle twitching	14.41	12.79	3	86666	8152	29857657
Lung adenocarcinoma stage I	14.41	12.79	4	86665	10	29865799
Astrocytoma	14.38	12.79	8	86661	172	29865637
Duodenal obstruction	14.37	12.79	7	86662	113	29865696
Human metapneumovirus test positive	14.37	12.79	6	86663	66	29865743
Body temperature decreased	14.34	12.79	5	86664	9650	29856159
Hypouricaemia	14.31	12.79	9	86660	244	29865565
Meningitis bacterial	14.31	12.79	17	86652	1112	29864697
Hypertension	14.30	12.79	256	86413	121098	29744711
Enteritis	14.24	12.79	47	86622	6598	29859211
Ureteric compression	14.20	12.79	5	86664	33	29865776
Areflexia	14.16	12.79	27	86642	2692	29863117
Dyskinesia	14.10	12.79	26	86643	21808	29844001
Hemiparesis	14.10	12.79	82	86587	14720	29851089
Chronic lymphocytic leukaemia recurrent	14.04	12.79	11	86658	427	29865382
Secondary immunodeficiency	14.02	12.79	10	86659	336	29865473
Hepatitis B surface antigen positive	13.95	12.79	7	86662	121	29865688
Mastitis	13.93	12.79	8	86661	183	29865626
Diverticulitis	13.92	12.79	18	86651	17427	29848382
Skin cancer	13.92	12.79	3	86666	7958	29857851
Respiratory depression	13.88	12.79	8	86661	11495	29854314
Peripheral T-cell lymphoma unspecified refractory	13.88	12.79	4	86665	12	29865797
Intracranial pressure increased	13.87	12.79	31	86638	3459	29862350
Cancer fatigue	13.82	12.79	5	86664	36	29865773
Pulmonary veno-occlusive disease	13.75	12.79	11	86658	440	29865369
Oral candidiasis	13.75	12.79	66	86603	11005	29854804
Guillain-Barre syndrome	13.74	12.79	39	86630	5044	29860765
Meningoradiculitis	13.59	12.79	5	86664	38	29865771
Iris atrophy	13.55	12.79	6	86663	77	29865732
Blood urea increased	13.53	12.79	46	86623	31335	29834474
Mucosal toxicity	13.52	12.79	8	86661	194	29865615
Acute respiratory distress syndrome	13.49	12.79	115	86554	23357	29842452
Acinetobacter sepsis	13.48	12.79	5	86664	39	29865770
Primary effusion lymphoma	13.48	12.79	5	86664	39	29865770
Obesity	13.47	12.79	4	86665	8551	29857258
Mononeuropathy multiplex	13.45	12.79	7	86662	131	29865678
Chronic lymphocytic leukaemia transformation	13.34	12.79	8	86661	199	29865610
Skin laceration	13.33	12.79	8	86661	11243	29854566
Rash maculo-papular	13.32	12.79	34	86635	25384	29840425
Diabetes mellitus	13.32	12.79	69	86600	41796	29824013
Gastrointestinal mucosal disorder	13.30	12.79	10	86659	365	29865444
Blood urine present	13.27	12.79	6	86663	9894	29855915
Neurological decompensation	13.23	12.79	24	86645	2304	29863505
Ventricular tachycardia	13.23	12.79	31	86638	23831	29841978
Condition aggravated	13.20	12.79	301	86368	137565	29728244
Geotrichum infection	13.15	12.79	11	86658	469	29865340
Type 2 diabetes mellitus	13.15	12.79	12	86657	13610	29852199
Deafness	13.15	12.79	62	86607	10263	29855546
Hepatosplenic T-cell lymphoma	13.13	12.79	11	86658	470	29865339
Coronary artery occlusion	13.13	12.79	8	86661	11149	29854660
Wound	13.11	12.79	10	86659	12392	29853417
Varicella	13.11	12.79	19	86650	1511	29864298
Frequent bowel movements	13.10	12.79	4	86665	8401	29857408
Liver tenderness	13.08	12.79	7	86662	139	29865670
Quadriplegia	13.06	12.79	19	86650	1516	29864293
Bladder cancer	13.03	12.79	5	86664	9097	29856712
Cryptococcal fungaemia	13.02	12.79	6	86663	85	29865724
Hypertensive crisis	12.99	12.79	4	86665	8353	29857456
Meningitis cryptococcal	12.98	12.79	22	86647	2002	29863807
Splenic candidiasis	12.96	12.79	6	86663	86	29865723
Non-Hodgkin's lymphoma unspecified histology aggressive	12.96	12.79	5	86664	44	29865765
Sinus bradycardia	12.92	12.79	9	86660	11686	29854123
Pyomyositis	12.90	12.79	7	86662	143	29865666
B precursor type acute leukaemia	12.90	12.79	6	86663	87	29865722
No adverse event	12.87	12.79	19	86650	17400	29848409
Acute myocardial infarction	12.82	12.79	95	86574	52844	29812965
Kidney transplant rejection	12.79	12.79	3	86666	7506	29858303
Renal disorder	12.79	12.79	31	86638	23553	29842256

Pharmacologic Action:

Source	Code	Description
ATC	L01CA02	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS Vinca alkaloids and analogues
FDA CS	M0022674	Vinca Alkaloids
FDA EPC	N0000175612	Vinca Alkaloid
MeSH PA	D050256	Antimitotic Agents
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D000972	Antineoplastic Agents, Phytogenic
MeSH PA	D050257	Tubulin Modulators
CHEBI has role	CHEBI:23888	drugs
CHEBI has role	CHEBI:35610	cytostatic
CHEBI has role	CHEBI:60832	tubulin modulators
CHEBI has role	CHEBI:61951	microtubule destabilising role
CHEBI has role	CHEBI:76924	plant metabolites

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Acute lymphoid leukemia	indication	91857003	DOID:9952
Diffuse non-Hodgkin's lymphoma, large cell	indication	109969005
Hodgkin's disease	indication	118599009
Non-Hodgkin's lymphoma	indication	118601006
Burkitt's lymphoma	indication	118617000
Rhabdomyosarcoma	indication	302847003	DOID:3247
Nephroblastoma	indication	302849000	DOID:2154
Follicular non-Hodgkin's lymphoma	indication	308121000
Neuroblastoma	indication	432328008	DOID:769
Astrocytoma, anaplastic	off-label use	55353007	DOID:3078
Ewing's sarcoma	off-label use	76909002	DOID:3369
Chronic lymphoid leukemia, disease	off-label use	92814006
Multiple myeloma	off-label use	109989006	DOID:9538
Mycosis fungoides	off-label use	118618005
Small cell carcinoma of lung	off-label use	254632001	DOID:5409
Glioblastoma multiforme of brain	off-label use	276828006	DOID:3073
Primary cutaneous T-cell lymphoma	off-label use	400122007
Ovarian Germ Cell Tumor Carcinoma	off-label use
Mycosis	contraindication	3218000	DOID:1564
Hyperbilirubinemia	contraindication	14783006	DOID:2741
Obstruction of bile duct	contraindication	30144000
Viral disease	contraindication	34014006	DOID:934
Hyperuricemia	contraindication	35885006	DOID:1920
Charcot-Marie-Tooth disease	contraindication	50548001
Hepatic failure	contraindication	59927004
Leukopenia	contraindication	84828003	DOID:615
Bacterial infectious disease	contraindication	87628006
Peripheral motor neuropathy	contraindication	95663000	DOID:683
Neuromyopathy	contraindication	255522009	DOID:440
Uric acid renal calculus	contraindication	274401005
Pregnancy, function	contraindication	289908002
Peripheral nerve disease	contraindication	302226006
Breastfeeding (mother)	contraindication	413712001
Chronic lung disease	contraindication	413839001
Protozoal Infection	contraindication
Polyneuropathies	contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.02	acidic
pKa2	13.81	acidic
pKa3	7.2	Basic
pKa4	6.58	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Tubulin beta	Tumour-associated antigen	P04350 P07437 P68371 Q13509 Q13885 Q3ZCM7 Q9BUF5 Q9BVA1 Q9H4B7	TBB1_HUMAN TBB2A_HUMAN TBB2B_HUMAN TBB3_HUMAN TBB4A_HUMAN TBB4B_HUMAN TBB5_HUMAN TBB6_HUMAN TBB8_HUMAN	INHIBITOR			SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Multidrug resistance-associated protein 7	Transporter	Q5T3U5	MRP7_HUMAN				WOMBAT-PK
Multidrug resistance-associated protein 1	Transporter	P33527	MRP1_HUMAN				WOMBAT-PK
Canalicular multispecific organic anion transporter 1	Transporter	Q92887	MRP2_HUMAN				WOMBAT-PK
Multidrug resistance protein 1	Transporter	P08183	MDR1_HUMAN				WOMBAT-PK
Tubulin	Structural		Q862F3_BOVIN Q862L2_BOVIN TBB2B_BOVIN		IC50	5.74	CHEMBL

External reference:

ID	Source
4019971	VUID
N0000148056	NUI
D02197	KEGG_DRUG
2068-78-2	SECONDARY_CAS_RN
4017542	VANDF
4019971	VANDF
C0591904	UMLSCUI
CHEBI:28445	CHEBI
R1Q	PDB_CHEM_ID
5978	PUBCHEM_CID
CHEMBL501867	ChEMBL_ID
CHEMBL90555	ChEMBL_ID
D014750	MESH_DESCRIPTOR_UI
1440	INN_ID
5J49Q6B70F	UNII
6785	IUPHAR_LIGAND_ID
DB00541	DRUGBANK_ID
11202	RXNORM
5133	MMSL
5675	MMSL
7308	MMSL
879	MMSL
d00401	MMSL
002656	NDDF
004894	NDDF
23079006	SNOMEDCT_US
387126006	SNOMEDCT_US
387427007	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Vincasar PFS	HUMAN PRESCRIPTION DRUG LABEL	1	0703-4402	INJECTION, SOLUTION	1 mg	INTRAVENOUS	ANDA	20 sections
Vincasar PFS	HUMAN PRESCRIPTION DRUG LABEL	1	0703-4412	INJECTION, SOLUTION	1 mg	INTRAVENOUS	ANDA	20 sections
VinCRIStine Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	61703-309	INJECTION, SOLUTION	1 mg	INTRAVENOUS	ANDA	22 sections
VinCRIStine Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	61703-309	INJECTION, SOLUTION	1 mg	INTRAVENOUS	ANDA	22 sections