vincristine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
vinca alkaloids 2825 57-22-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vincristine
  • (+)-Vincristine
  • leucristine
  • vincristin
  • vinkristin
  • 22-oxo-vincaleukoblastine
  • vincristine sulfate
  • oncovin
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
  • Molecular weight: 824.97
  • Formula: C46H56N4O10
  • CLOGP: 4.04
  • LIPINSKI: 2
  • HAC: 14
  • HDO: 3
  • TPSA: 171.17
  • ALOGS: -4.44
  • ROTB: 10
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 15 % Benet LZ, Broccatelli F, Oprea TI
Vd (Volume of distribution) 2.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.40 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 23 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 10, 1963 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 3992.66 13.52 2203 70549 102733 53173581
Neutropenia 1542.75 13.52 1456 71296 157729 53118585
Febrile bone marrow aplasia 865.62 13.52 337 72415 6852 53269462
Haematotoxicity 646.80 13.52 281 72471 7616 53268698
Pancytopenia 637.86 13.52 700 72052 90228 53186086
Bone marrow failure 624.35 13.52 431 72321 29684 53246630
Product use in unapproved indication 621.29 13.52 765 71987 111524 53164790
Mucosal inflammation 597.48 13.52 483 72269 42301 53234013
Diffuse large B-cell lymphoma recurrent 558.76 13.52 169 72583 1527 53274787
Myelodysplastic syndrome 515.59 13.52 307 72445 16353 53259961
Posterior reversible encephalopathy syndrome 505.88 13.52 300 72452 15860 53260454
Second primary malignancy 501.29 13.52 228 72524 6904 53269410
Acute myeloid leukaemia 492.93 13.52 300 72452 16632 53259682
Thrombocytopenia 488.30 13.52 760 71992 137967 53138347
Sepsis 469.81 13.52 769 71983 145660 53130654
Venoocclusive liver disease 448.64 13.52 185 72567 4387 53271927
Tumour lysis syndrome 431.37 13.52 212 72540 7662 53268652
Rheumatoid arthritis 407.47 13.52 4 72748 314527 52961787
Septic shock 406.72 13.52 462 72290 61767 53214547
Diffuse large B-cell lymphoma 361.80 13.52 178 72574 6447 53269867
Neurotoxicity 347.31 13.52 232 72520 15117 53261197
Acute lymphocytic leukaemia recurrent 341.68 13.52 125 72627 2123 53274191
Pain 336.96 13.52 193 72559 588205 52688109
Hypofibrinogenaemia 323.33 13.52 102 72650 1073 53275241
Pyrexia 306.90 13.52 1222 71530 401971 52874343
Ovarian failure 292.64 13.52 94 72658 1053 53275261
Hepatitis B 278.47 13.52 126 72626 3766 53272548
Progressive multifocal leukoencephalopathy 278.43 13.52 185 72567 11944 53264370
Neutropenic sepsis 276.35 13.52 198 72554 14451 53261863
Myelosuppression 276.12 13.52 188 72564 12640 53263674
Joint swelling 250.80 13.52 18 72734 234620 53041694
Disease progression 248.51 13.52 475 72277 101445 53174869
Multiple organ dysfunction syndrome 243.13 13.52 338 72414 55339 53220975
Acute lymphocytic leukaemia 241.27 13.52 104 72648 2761 53273553
Diffuse large B-cell lymphoma refractory 233.42 13.52 78 72674 998 53275316
Disease recurrence 227.81 13.52 205 72547 20741 53255573
Cardiotoxicity 227.05 13.52 135 72617 7164 53269150
Fall 224.88 13.52 104 72648 358336 52917978
Staphylococcal bacteraemia 223.08 13.52 119 72633 5114 53271200
Neutrophil count decreased 215.76 13.52 299 72453 48799 53227515
Abdominal discomfort 207.44 13.52 28 72724 221034 53055280
Product dose omission issue 206.76 13.52 14 72738 191606 53084708
Leukopenia 206.28 13.52 364 72388 73099 53203215
Off label use 205.17 13.52 1219 71533 470993 52805321
Pruritus 204.14 13.52 73 72679 293759 52982555
Neuropathy peripheral 204.09 13.52 441 72311 102746 53173568
Neutropenic colitis 201.67 13.52 89 72663 2504 53273810
Haemophagocytic lymphohistiocytosis 199.23 13.52 135 72617 9002 53267312
Maternal exposure before pregnancy 197.58 13.52 113 72639 5573 53270741
Nasopharyngitis 196.42 13.52 18 72734 192277 53084037
Aplasia 191.96 13.52 100 72652 4092 53272222
Fatigue 190.65 13.52 450 72302 730056 52546258
Post transplant lymphoproliferative disorder 185.20 13.52 99 72653 4272 53272042
Neoplasm progression 183.33 13.52 215 72537 29704 53246610
Platelet count decreased 182.61 13.52 434 72318 107665 53168649
Pneumocystis jirovecii pneumonia 181.47 13.52 162 72590 16216 53260098
Peripheral swelling 179.97 13.52 32 72720 206076 53070238
Arthralgia 177.92 13.52 203 72549 439580 52836734
Hepatitis B reactivation 176.04 13.52 75 72677 1933 53274381
B-cell lymphoma recurrent 172.21 13.52 50 72702 386 53275928
Drug resistance 170.60 13.52 171 72581 19791 53256523
Epstein-Barr virus infection 165.08 13.52 111 72641 7307 53269007
Hypertriglyceridaemia 163.93 13.52 104 72648 6200 53270114
Ileus paralytic 163.88 13.52 93 72659 4518 53271796
Rash 158.66 13.52 227 72525 445964 52830350
Contraindicated product administered 158.61 13.52 6 72746 135623 53140691
Headache 156.92 13.52 310 72442 536511 52739803
Drug hypersensitivity 154.14 13.52 85 72667 265157 53011157
Weight increased 154.08 13.52 44 72708 204523 53071791
Arthropathy 150.62 13.52 11 72741 141442 53134872
Dizziness 150.27 13.52 172 72580 372087 52904227
Hyperbilirubinaemia 150.21 13.52 123 72629 10946 53265368
Swelling 145.98 13.52 40 72712 191065 53085249
Cardiomyopathy 145.32 13.52 146 72606 16942 53259372
Cytopenia 143.93 13.52 111 72641 9059 53267255
Neoplasm recurrence 143.18 13.52 69 72683 2385 53273929
Leukoencephalopathy 136.28 13.52 80 72672 4144 53272170
Anxiety 132.91 13.52 51 72701 196653 53079661
Feeling abnormal 132.06 13.52 15 72737 135286 53141028
Synovitis 128.85 13.52 4 72748 107889 53168425
Malignant neoplasm progression 128.14 13.52 294 72458 71247 53205067
Insomnia 127.22 13.52 48 72704 187024 53089290
Mucormycosis 124.73 13.52 64 72688 2536 53273778
Blood culture positive 124.45 13.52 78 72674 4551 53271763
Pneumatosis intestinalis 121.59 13.52 60 72692 2186 53274128
Injection site pain 120.18 13.52 9 72743 113382 53162932
Bacteraemia 119.82 13.52 126 72626 15423 53260891
Sinusitis 118.43 13.52 41 72711 168523 53107791
Drug intolerance 116.25 13.52 68 72684 205425 53070889
Musculoskeletal stiffness 114.75 13.52 16 72736 123352 53152962
Anaemia 114.36 13.52 706 72046 276012 53000302
Hypogammaglobulinaemia 110.03 13.52 80 72672 5970 53270344
Disseminated intravascular coagulation 109.79 13.52 135 72617 19584 53256730
White blood cell count decreased 108.71 13.52 395 72357 124080 53152234
Blood lactate dehydrogenase increased 108.40 13.52 141 72611 21640 53254674
Temporal lobe epilepsy 107.48 13.52 34 72718 361 53275953
Asthma 106.54 13.52 12 72740 108960 53167354
Therapy partial responder 106.45 13.52 79 72673 6084 53270230
Psoriasis 104.82 13.52 3 72749 87086 53189228
Lymphopenia 104.76 13.52 122 72630 16721 53259593
Cerebral venous thrombosis 104.71 13.52 55 72697 2289 53274025
Drug ineffective 103.38 13.52 673 72079 816572 52459742
Polyneuropathy 103.34 13.52 108 72644 13125 53263189
Dyspnoea 103.11 13.52 431 72321 585801 52690513
Respiratory failure 102.61 13.52 336 72416 100176 53176138
Central nervous system lymphoma 102.44 13.52 47 72705 1451 53274863
Therapeutic product effect decreased 102.32 13.52 23 72729 125632 53150682
Myelopathy 102.25 13.52 57 72695 2674 53273640
Secondary immunodeficiency 102.25 13.52 43 72709 1072 53275242
Malaise 102.13 13.52 209 72543 357408 52918906
Systemic candida 101.53 13.52 59 72693 2998 53273316
Pleural effusion 101.33 13.52 308 72444 88271 53188043
Wound 100.74 13.52 6 72746 91551 53184763
Lennox-Gastaut syndrome 96.35 13.52 29 72723 257 53276057
Bone pain 95.88 13.52 213 72539 50509 53225805
Blood pressure increased 95.56 13.52 36 72716 140443 53135871
Stem cell transplant 93.12 13.52 47 72705 1798 53274516
Fungaemia 91.36 13.52 49 72703 2128 53274186
Pain in extremity 89.75 13.52 157 72595 284893 52991421
Discomfort 89.68 13.52 12 72740 95460 53180854
Ascites 89.19 13.52 179 72573 39556 53236758
Smooth muscle cell neoplasm 88.30 13.52 34 72718 669 53275645
Arthritis 86.89 13.52 9 72743 87289 53189025
Hepatic failure 86.05 13.52 166 72586 35640 53240674
Venoocclusive disease 85.53 13.52 46 72706 2009 53274305
Epstein-Barr virus associated lymphoproliferative disorder 85.15 13.52 43 72709 1647 53274667
Klebsiella infection 85.03 13.52 77 72675 7849 53268465
Contusion 84.84 13.52 23 72729 110709 53165605
Peripheral motor neuropathy 84.63 13.52 42 72710 1549 53274765
Cerebral venous sinus thrombosis 82.10 13.52 44 72708 1908 53274406
Ejection fraction decreased 81.40 13.52 117 72635 19731 53256583
Muscle spasms 79.95 13.52 42 72710 134753 53141561
Enterococcal infection 79.91 13.52 73 72679 7525 53268789
Leukaemia recurrent 79.87 13.52 39 72713 1388 53274926
Lymphadenopathy 79.79 13.52 162 72590 36093 53240221
Overdose 79.54 13.52 24 72728 107712 53168602
Hepatocellular injury 79.51 13.52 145 72607 29841 53246473
B-cell lymphoma 77.48 13.52 52 72700 3411 53272903
Clostridium difficile colitis 77.40 13.52 114 72638 19651 53256663
Injection site erythema 76.79 13.52 8 72744 77241 53199073
Agranulocytosis 76.27 13.52 125 72627 23624 53252690
Nephroblastoma 75.79 13.52 20 72732 103 53276211
Depression 74.33 13.52 84 72668 182968 53093346
Superior sagittal sinus thrombosis 73.79 13.52 32 72720 862 53275452
Alopecia 73.09 13.52 130 72622 234453 53041861
Aspergillus infection 73.00 13.52 69 72683 7427 53268887
Congestive cardiomyopathy 72.55 13.52 63 72689 6075 53270239
Escherichia bacteraemia 72.40 13.52 49 72703 3259 53273055
Bronchopulmonary aspergillosis 71.77 13.52 73 72679 8592 53267722
Colitis 71.34 13.52 168 72584 41384 53234930
Inappropriate schedule of product administration 71.31 13.52 9 72743 74869 53201445
Bronchitis 69.16 13.52 33 72719 111866 53164448
Cystitis haemorrhagic 69.11 13.52 51 72701 3893 53272421
Migraine 69.01 13.52 13 72739 80404 53195910
Urticaria 68.63 13.52 51 72701 135834 53140480
Hypersensitivity 68.12 13.52 114 72638 210551 53065763
Enterococcal bacteraemia 67.26 13.52 34 72718 1305 53275009
Hospitalisation 66.51 13.52 9 72743 71003 53205311
Peripheral sensory neuropathy 66.21 13.52 64 72688 7084 53269230
Gene mutation 65.68 13.52 33 72719 1250 53275064
Abdominal pain upper 65.68 13.52 78 72674 166213 53110101
Cervix disorder 65.25 13.52 25 72727 485 53275829
Pseudomonas test positive 64.37 13.52 28 72724 760 53275554
B precursor type acute leukaemia 63.77 13.52 20 72732 206 53276108
Condition aggravated 62.17 13.52 203 72549 296931 52979383
Palpitations 62.01 13.52 31 72721 102317 53173997
Candida infection 61.74 13.52 118 72634 25155 53251159
Refractory anaemia with an excess of blasts 61.32 13.52 23 72729 420 53275894
Encephalopathy 61.21 13.52 147 72605 36661 53239653
Chest pain 60.49 13.52 104 72648 190081 53086233
Retinoblastoma 60.37 13.52 17 72735 116 53276198
Pneumocystis jirovecii infection 60.19 13.52 32 72720 1365 53274949
JC virus infection 59.81 13.52 35 72717 1802 53274512
Respiratory distress 59.41 13.52 138 72614 33689 53242625
Quadriplegia 59.09 13.52 35 72717 1843 53274471
Myeloid leukaemia 59.01 13.52 21 72731 328 53275986
Rhinovirus infection 58.94 13.52 46 72706 3819 53272495
Vocal cord paralysis 58.90 13.52 35 72717 1854 53274460
Cytomegalovirus infection 57.62 13.52 99 72653 19440 53256874
Pneumonia fungal 57.49 13.52 49 72703 4607 53271707
Lymphoma transformation 57.37 13.52 17 72735 142 53276172
Ileus 56.75 13.52 85 72667 14870 53261444
Herpes simplex 56.66 13.52 61 72691 7668 53268646
Hepatomegaly 56.40 13.52 75 72677 11756 53264558
Astrocytoma, low grade 56.33 13.52 14 72738 54 53276260
Acute myelomonocytic leukaemia 56.32 13.52 18 72734 198 53276116
Glioma 56.22 13.52 20 72732 312 53276002
Nausea 55.77 13.52 713 72039 755378 52520936
Lymphoma 55.52 13.52 70 72682 10412 53265902
Infection 55.22 13.52 413 72339 171792 53104522
Injection site reaction 54.37 13.52 4 72748 51162 53225152
Epstein-Barr virus associated lymphoma 53.90 13.52 21 72731 427 53275887
Fusarium infection 53.86 13.52 23 72729 596 53275718
Enterovirus test positive 53.85 13.52 16 72736 135 53276179
Antithrombin III decreased 53.73 13.52 19 72733 291 53276023
Bacterial sepsis 53.69 13.52 44 72708 3918 53272396
Hepatic enzyme increased 53.32 13.52 56 72696 126139 53150175
Osteoarthritis 53.30 13.52 15 72737 70471 53205843
Loss of personal independence in daily activities 52.53 13.52 15 72737 69800 53206514
Venous thrombosis 52.39 13.52 48 72704 4966 53271348
Blood fibrinogen decreased 52.33 13.52 24 72728 740 53275574
Intentional product misuse 52.09 13.52 4 72748 49388 53226926
Pericarditis 51.98 13.52 12 72740 64394 53211920
Human bocavirus infection 51.85 13.52 19 72733 324 53275990
Osteonecrosis 51.79 13.52 113 72639 26462 53249852
Pulmonary haemorrhage 51.32 13.52 55 72697 6878 53269436
Hyperglycaemia 51.17 13.52 145 72607 39939 53236375
Device related infection 50.35 13.52 102 72650 22684 53253630
Ototoxicity 50.12 13.52 27 72725 1183 53275131
Pyomyositis 49.76 13.52 19 72733 365 53275949
Heart rate abnormal 49.19 13.52 42 72710 3958 53272356
Hepatotoxicity 48.15 13.52 113 72639 27767 53248547
Influenza like illness 47.82 13.52 12 72740 60847 53215467
Cytokine release syndrome 47.43 13.52 57 72695 8072 53268242
Lower respiratory tract infection 47.42 13.52 33 72719 90948 53185366
Stomatitis 47.25 13.52 261 72491 97897 53178417
Human herpesvirus 6 infection 47.25 13.52 34 72718 2496 53273818
Left ventricular dysfunction 47.19 13.52 67 72685 11170 53265144
Human rhinovirus test positive 46.94 13.52 15 72737 165 53276149
Mantle cell lymphoma recurrent 46.93 13.52 14 72738 120 53276194
Neck pain 46.84 13.52 12 72740 60004 53216310
Perineal necrosis 46.82 13.52 14 72738 121 53276193
Lung infiltration 46.67 13.52 77 72675 14630 53261684
Hyperpyrexia 46.64 13.52 38 72714 3356 53272958
Cutaneous calcification 46.26 13.52 13 72739 88 53276226
Drug abuse 45.87 13.52 16 72736 65510 53210804
Staphylococcal sepsis 45.79 13.52 55 72697 7785 53268529
Leukaemia cutis 45.76 13.52 13 72739 92 53276222
Diarrhoea 45.63 13.52 591 72161 624955 52651359
Suicidal ideation 45.53 13.52 13 72739 60498 53215816
Perineal infection 45.37 13.52 14 72738 136 53276178
Toxic neuropathy 45.35 13.52 18 72734 385 53275929
Cardiac failure 45.23 13.52 234 72518 85610 53190704
Premature menopause 44.97 13.52 22 72730 786 53275528
Mobility decreased 44.86 13.52 24 72728 76247 53200067
Philadelphia chromosome positive 44.70 13.52 17 72735 323 53275991
Enterobacter infection 44.45 13.52 30 72722 1986 53274328
Hot flush 44.10 13.52 6 72746 47154 53229160
Choriocarcinoma 43.93 13.52 13 72739 108 53276206
T-cell lymphoma 43.46 13.52 21 72731 730 53275584
Injection site swelling 43.45 13.52 4 72748 42624 53233690
Histiocytic sarcoma 43.25 13.52 12 72740 77 53276237
Blister 43.16 13.52 27 72725 78726 53197588
Inappropriate antidiuretic hormone secretion 43.10 13.52 75 72677 14876 53261438
Salivary gland cancer 43.09 13.52 14 72738 163 53276151
Brain oedema 43.04 13.52 71 72681 13487 53262827
B-cell lymphoma refractory 42.60 13.52 12 72740 82 53276232
Irritable bowel syndrome 42.14 13.52 5 72747 43627 53232687
Injury 42.14 13.52 9 72743 50962 53225352
Injection site pruritus 42.13 13.52 4 72748 41585 53234729
Osteomyelitis bacterial 42.12 13.52 14 72738 176 53276138
Bone marrow disorder 41.86 13.52 29 72723 2004 53274310
Adverse drug reaction 41.32 13.52 11 72741 53614 53222700
Back pain 41.11 13.52 172 72580 234075 53042239
Suicide attempt 41.07 13.52 14 72738 58154 53218160
Intussusception 40.96 13.52 18 72734 501 53275813
Coagulopathy 40.96 13.52 86 72666 19612 53256702
Hepatitis E 40.93 13.52 24 72728 1240 53275074
Acute hepatitis B 40.85 13.52 16 72736 330 53275984
Mucosal toxicity 40.72 13.52 16 72736 333 53275981
Incorrect dose administered 40.23 13.52 10 72742 51035 53225279
Combined immunodeficiency 40.00 13.52 12 72740 105 53276209
Cerebrovascular accident 39.75 13.52 51 72701 105123 53171191
Growth hormone deficiency 39.73 13.52 13 72739 155 53276159
Desmoplastic small round cell tumour 39.61 13.52 14 72738 214 53276100
Humoral immune defect 39.46 13.52 11 72741 72 53276242
Bacterial infection 39.30 13.52 79 72673 17468 53258846
Dry mouth 39.25 13.52 16 72736 59534 53216780
Transverse sinus thrombosis 39.18 13.52 19 72733 666 53275648
Herpes zoster meningoencephalitis 39.15 13.52 15 72737 291 53276023
Gastrosplenic fistula 39.00 13.52 10 72742 45 53276269
Depressed mood 38.96 13.52 3 72749 36961 53239353
Myocardial infarction 38.78 13.52 47 72705 99307 53177007
Hypoalbuminaemia 38.45 13.52 60 72692 10876 53265438
5q minus syndrome 38.35 13.52 14 72738 236 53276078
Medulloblastoma recurrent 38.22 13.52 11 72741 82 53276232
Lymphoproliferative disorder 38.18 13.52 32 72720 2940 53273374
Impaired healing 38.06 13.52 20 72732 64185 53212129
Lymphadenitis 37.89 13.52 31 72721 2754 53273560
Blood glucose increased 37.81 13.52 30 72722 77331 53198983
Cholestasis 37.80 13.52 105 72647 28590 53247724
Plasmablastic lymphoma 37.77 13.52 14 72738 247 53276067
Cytomegalovirus colitis 37.51 13.52 27 72725 1983 53274331
Myalgia 37.17 13.52 79 72673 133412 53142902
Blood pressure fluctuation 37.04 13.52 3 72749 35467 53240847
Sleep disorder 36.92 13.52 17 72735 58853 53217461
Gastroenteritis norovirus 36.81 13.52 25 72727 1672 53274642
BK virus infection 36.72 13.52 32 72720 3100 53273214
Cough 36.71 13.52 203 72549 256690 53019624
Hyperhidrosis 36.51 13.52 47 72705 96746 53179568
Memory impairment 36.48 13.52 37 72715 84720 53191594
Urinary tract infection 36.26 13.52 186 72566 239717 53036597
Seizure 36.20 13.52 301 72451 129208 53147106
Acute promyelocytic leukaemia 36.09 13.52 20 72732 927 53275387
Platelet count abnormal 36.08 13.52 31 72721 2947 53273367
Chest discomfort 35.99 13.52 50 72702 99645 53176669
Hemiparesis 35.95 13.52 86 72666 21389 53254925
Therapeutic response delayed 35.89 13.52 17 72735 565 53275749
Gastrooesophageal reflux disease 35.68 13.52 36 72716 82627 53193687
Unmasking of previously unidentified disease 35.62 13.52 19 72733 816 53275498
Areflexia 35.56 13.52 31 72721 3005 53273309
Paraparesis 35.22 13.52 27 72725 2183 53274131
Pneumonia 35.06 13.52 763 71989 406406 52869908
Leukoerythroblastosis 34.98 13.52 13 72739 231 53276083
Babesiosis 34.98 13.52 13 72739 231 53276083
Recurrent cancer 34.96 13.52 25 72727 1817 53274497
Burning sensation 34.87 13.52 11 72741 48002 53228312
Glioblastoma multiforme 34.76 13.52 19 72733 857 53275457
Haemorrhage intracranial 34.67 13.52 64 72688 13288 53263026
Listeria sepsis 34.48 13.52 17 72735 618 53275696
Confusional state 34.44 13.52 142 72610 194079 53082235
Acute respiratory distress syndrome 34.39 13.52 89 72663 23243 53253071
Rhinocerebral mucormycosis 34.22 13.52 12 72740 179 53276135
Erythropoiesis abnormal 33.84 13.52 13 72739 254 53276060
Leukaemic lymphoma 33.80 13.52 10 72742 83 53276231
Clostridium test positive 33.79 13.52 27 72725 2319 53273995
Hepatic infarction 33.78 13.52 17 72735 646 53275668
Cytogenetic abnormality 33.69 13.52 16 72736 535 53275779
Nail pigmentation 33.57 13.52 12 72740 190 53276124
Malignant transformation 33.55 13.52 14 72738 342 53275972
Somnolence 33.39 13.52 117 72635 167617 53108697
Acute biphenotypic leukaemia 33.39 13.52 9 72743 51 53276263
Staphylococcal infection 33.32 13.52 122 72630 38426 53237888
Oesophageal candidiasis 33.03 13.52 39 72713 5421 53270893
Cytomegalovirus chorioretinitis 32.73 13.52 23 72729 1626 53274688
Femur fracture 32.70 13.52 7 72745 39578 53236736
Cytomegalovirus viraemia 32.46 13.52 37 72715 4954 53271360
Intracardiac thrombus 32.39 13.52 27 72725 2462 53273852
Pseudomonas infection 32.28 13.52 54 72698 10374 53265940
Cardiomyopathy acute 32.15 13.52 12 72740 216 53276098
Gastrointestinal necrosis 32.06 13.52 29 72723 2951 53273363
Infection reactivation 32.00 13.52 19 72733 1005 53275309
White blood cell count abnormal 31.97 13.52 38 72714 5320 53270994
Vision blurred 31.84 13.52 42 72710 85562 53190752
Varicella zoster virus infection 31.70 13.52 27 72725 2536 53273778
Blast cells present 31.65 13.52 14 72738 396 53275918
Hallucination 31.57 13.52 17 72735 53821 53222493
Tissue infiltration 31.46 13.52 16 72736 622 53275692
Nephrolithiasis 31.39 13.52 6 72746 36741 53239573
Encephalitis 31.36 13.52 46 72706 7898 53268416
Pneumonia cytomegaloviral 31.29 13.52 25 72727 2147 53274167
Necrotising gastritis 31.28 13.52 9 72743 67 53276247
Pseudomonal sepsis 31.22 13.52 25 72727 2154 53274160
Feeling hot 31.11 13.52 9 72743 41535 53234779
Musculoskeletal pain 31.05 13.52 34 72718 75166 53201148
Wheezing 31.04 13.52 26 72726 65249 53211065
Antithrombin III 31.01 13.52 11 72741 170 53276144
Nasal congestion 30.99 13.52 17 72735 53270 53223044
Capillary leak syndrome 30.88 13.52 24 72728 1980 53274334
Tumour necrosis 30.86 13.52 17 72735 779 53275535
Gestational trophoblastic tumour 30.35 13.52 8 72744 41 53276273
Oedema peripheral 30.19 13.52 125 72627 170662 53105652
Carotid intima-media thickness increased 30.18 13.52 9 72743 77 53276237
Potentiating drug interaction 30.18 13.52 33 72719 4220 53272094
Surgery 30.05 13.52 4 72748 31960 53244354
Philadelphia positive acute lymphocytic leukaemia 30.03 13.52 8 72744 43 53276271
Unevaluable event 29.96 13.52 15 72737 49483 53226831
Cryptococcosis 29.94 13.52 18 72734 974 53275340
Hyperammonaemia 29.87 13.52 36 72716 5113 53271201
Candida test positive 29.74 13.52 18 72734 986 53275328
Haemolytic uraemic syndrome 29.69 13.52 26 72726 2535 53273779
Premature baby 29.66 13.52 76 72676 19725 53256589
Heart rate decreased 29.58 13.52 7 72745 36940 53239374
Blood cholesterol increased 29.26 13.52 18 72734 52971 53223343
Escherichia test positive 29.25 13.52 24 72728 2141 53274173
Mucoepidermoid carcinoma 29.15 13.52 8 72744 49 53276265
Refractory cytopenia with multilineage dysplasia 29.10 13.52 10 72742 140 53276174
Flushing 29.06 13.52 32 72720 70568 53205746
Dyspepsia 28.94 13.52 38 72714 77562 53198752
Cerebellar stroke 28.92 13.52 11 72741 209 53276105
Trichodysplasia spinulosa 28.55 13.52 14 72738 503 53275811
Acquired gene mutation 28.50 13.52 16 72736 761 53275553
Leukaemia 28.49 13.52 30 72722 3676 53272638
Aplastic anaemia 28.35 13.52 45 72707 8276 53268038
Loss of consciousness 28.24 13.52 72 72680 114140 53162174
Chronic kidney disease 28.02 13.52 12 72740 43358 53232956
Joint stiffness 27.97 13.52 4 72748 30279 53246035
Subdural hygroma 27.95 13.52 11 72741 230 53276084
Encephalitis viral 27.91 13.52 21 72731 1651 53274663
Product quality issue 27.76 13.52 8 72744 37015 53239299
Klebsiella bacteraemia 27.55 13.52 19 72733 1303 53275011
Duodenal ulcer perforation 27.52 13.52 7 72745 35176 53241138
Rhinorrhoea 27.17 13.52 20 72732 53558 53222756
Subclavian vein thrombosis 27.13 13.52 22 72730 1930 53274384
Therapy responder 27.07 13.52 12 72740 341 53275973
Jugular vein thrombosis 27.03 13.52 26 72726 2860 53273454
Ureaplasma infection 27.02 13.52 14 72738 566 53275748
Angiocentric lymphoma 26.98 13.52 14 72738 568 53275746
Mediastinum neoplasm 26.87 13.52 8 72744 68 53276246
Therapy non-responder 26.63 13.52 135 72617 48985 53227329
Sinusitis fungal 26.59 13.52 19 72733 1379 53274935
Helicobacter infection 26.56 13.52 10 72742 39059 53237255
Hepatosplenic candidiasis 26.54 13.52 11 72741 264 53276050
Pulse waveform abnormal 26.47 13.52 8 72744 72 53276242
Ankle brachial index decreased 26.37 13.52 8 72744 73 53276241
Emotional distress 26.12 13.52 6 72746 32311 53244003
Basal ganglion degeneration 26.11 13.52 13 72739 483 53275831
Small intestinal obstruction 25.88 13.52 66 72686 17081 53259233
Ocular vascular disorder 25.87 13.52 12 72740 380 53275934
Splenomegaly 25.81 13.52 49 72703 10390 53265924
Acute lymphocytic leukaemia refractory 25.81 13.52 8 72744 79 53276235
Metastasis 25.70 13.52 32 72720 4699 53271615
Ill-defined disorder 25.67 13.52 18 72734 49426 53226888
Gastric disorder 25.61 13.52 5 72747 30160 53246154
Escherichia infection 25.51 13.52 53 72699 11997 53264317
Primary immunodeficiency syndrome 25.49 13.52 7 72745 43 53276271
Premature delivery 25.47 13.52 86 72666 26018 53250296
International normalised ratio increased 25.31 13.52 17 72735 47744 53228570
Abdominal neoplasm 25.31 13.52 11 72741 298 53276016
B-cell type acute leukaemia 25.26 13.52 9 72743 141 53276173
Infusion related reaction 25.23 13.52 118 72634 155839 53120475
Toxic cardiomyopathy 25.20 13.52 9 72743 142 53276172
Traumatic lung injury 25.14 13.52 19 72733 1504 53274810
Atypical haemolytic uraemic syndrome 25.04 13.52 13 72739 528 53275786
Clostridium difficile infection 24.71 13.52 89 72663 27804 53248510
Influenza 24.46 13.52 59 72693 95320 53180994
Hepatitis C RNA increased 24.32 13.52 9 72743 158 53276156
Chronic myelomonocytic leukaemia 24.27 13.52 11 72741 330 53275984
Chronic hepatitis 24.18 13.52 15 72737 859 53275455
Alveolar soft part sarcoma 24.18 13.52 8 72744 99 53276215
Rhabdomyosarcoma recurrent 24.17 13.52 6 72746 23 53276291
Multiple sclerosis 24.13 13.52 4 72748 27149 53249165
Bone marrow transplant 24.10 13.52 14 72738 711 53275603
Gait disturbance 24.06 13.52 123 72629 158719 53117595
Intestinal perforation 24.03 13.52 50 72702 11330 53264984
Uterine enlargement 24.00 13.52 17 72735 1217 53275097
Blood pressure systolic increased 23.92 13.52 9 72743 35168 53241146
Pulmonary toxicity 23.91 13.52 33 72719 5358 53270956
IIIrd nerve paralysis 23.88 13.52 14 72738 723 53275591
Streptococcus test positive 23.78 13.52 17 72735 1235 53275079
Geotrichum infection 23.75 13.52 12 72740 460 53275854
Soft tissue infection 23.70 13.52 21 72731 2080 53274234
Angioedema 23.64 13.52 14 72738 42062 53234252
Localised infection 23.60 13.52 4 72748 26712 53249602
Metastases to meninges 23.37 13.52 21 72731 2118 53274196
Escherichia sepsis 23.32 13.52 30 72722 4551 53271763
Dry skin 23.31 13.52 17 72735 45743 53230571
Flatulence 23.29 13.52 7 72745 31510 53244804
Mantle cell lymphoma 23.26 13.52 13 72739 613 53275701
Hypertransaminasaemia 23.17 13.52 28 72724 3988 53272326
Fluid retention 23.12 13.52 24 72728 54377 53221937
Blood immunoglobulin G decreased 22.81 13.52 20 72732 1953 53274361
Weight decreased 22.62 13.52 208 72544 234740 53041574
T-cell type acute leukaemia 22.59 13.52 7 72745 69 53276245
COVID-19 22.59 13.52 105 72647 36783 53239531
Head injury 22.53 13.52 4 72748 25829 53250485
Gastric stenosis 22.50 13.52 7 72745 70 53276244
Hereditary motor and sensory neuropathy 22.50 13.52 7 72745 70 53276244
Rash pruritic 22.48 13.52 21 72731 49989 53226325
Partial seizures 22.47 13.52 32 72720 5348 53270966
Balance disorder 22.37 13.52 41 72711 73166 53203148
Neutropenic infection 22.28 13.52 16 72736 1171 53275143
Renal replacement therapy 22.26 13.52 6 72746 34 53276280
Dry eye 22.23 13.52 9 72743 33635 53242679
Visual impairment 22.13 13.52 41 72711 72871 53203443
Nervous system disorder 22.11 13.52 63 72689 17401 53258913
Parainfluenzae virus infection 22.10 13.52 20 72732 2036 53274278
Axonal neuropathy 22.02 13.52 15 72737 1008 53275306
Alveolar rhabdomyosarcoma 21.97 13.52 6 72746 36 53276278
Alanine aminotransferase increased 21.93 13.52 212 72540 94883 53181431
Erythema 21.87 13.52 125 72627 156844 53119470
Mucosal infection 21.85 13.52 8 72744 136 53276178
Wrong technique in product usage process 21.77 13.52 30 72722 60002 53216312
Epstein Barr virus positive mucocutaneous ulcer 21.73 13.52 10 72742 311 53276003
Throat irritation 21.72 13.52 8 72744 31673 53244641
Polyomavirus-associated nephropathy 21.69 13.52 18 72734 1631 53274683
Renal vein thrombosis 21.64 13.52 10 72742 314 53276000
Generalised tonic-clonic seizure 21.55 13.52 87 72665 28671 53247643
Treatment failure 21.45 13.52 96 72656 128307 53148007
Retinal pigment epitheliopathy 21.41 13.52 9 72743 224 53276090
Paraplegia 21.38 13.52 22 72730 2625 53273689
Platelet transfusion 21.19 13.52 13 72739 730 53275584
Serotonin syndrome 21.15 13.52 5 72747 26401 53249913
Jejunal stenosis 21.05 13.52 6 72746 43 53276271
Duodenal stenosis 21.05 13.52 12 72740 588 53275726
Cataract 20.96 13.52 22 72730 49598 53226716
Blood stem cell transplant failure 20.94 13.52 8 72744 154 53276160
Skin discolouration 20.80 13.52 11 72741 35181 53241133
Angioimmunoblastic T-cell lymphoma 20.79 13.52 8 72744 157 53276157
Peritonitis viral 20.48 13.52 6 72746 48 53276266
Hepatic function abnormal 20.41 13.52 102 72650 36797 53239517
General physical health deterioration 20.32 13.52 297 72455 146645 53129669
Pharyngeal inflammation 20.29 13.52 12 72740 630 53275684
Granulocytopenia 20.24 13.52 31 72721 5529 53270785
Joint injury 20.22 13.52 3 72749 22097 53254217
Limb discomfort 20.11 13.52 5 72747 25517 53250797
Haemoglobin abnormal 20.10 13.52 28 72724 4586 53271728
Chronic lymphocytic leukaemia 20.09 13.52 23 72729 3093 53273221
Post lumbar puncture syndrome 20 13.52 12 72740 647 53275667
Disturbance in attention 19.95 13.52 11 72741 34372 53241942
Abnormal behaviour 19.93 13.52 3 72749 21863 53254451
Blood bilirubin increased 19.93 13.52 99 72653 35631 53240683
Tooth disorder 19.86 13.52 5 72747 25307 53251007
Hepatitis acute 19.80 13.52 40 72712 8876 53267438
Cardiopulmonary failure 19.78 13.52 25 72727 3726 53272588
Congenital retinoblastoma 19.78 13.52 5 72747 21 53276293
Paranasal sinus mucosal hypertrophy 19.78 13.52 5 72747 21 53276293
Pseudomonal bacteraemia 19.78 13.52 16 72736 1399 53274915
Pneumonia influenzal 19.76 13.52 17 72735 1618 53274696
Chronic obstructive pulmonary disease 19.75 13.52 33 72719 61040 53215274
Tachycardia 19.69 13.52 230 72522 107982 53168332
Nephropathy toxic 19.68 13.52 39 72713 8533 53267781
Death 19.61 13.52 356 72396 356876 52919438
Brain injury 19.60 13.52 33 72719 6372 53269942
Central nervous system enteroviral infection 19.59 13.52 5 72747 22 53276292
Acne 19.59 13.52 3 72749 21583 53254731
Graft versus host disease 19.59 13.52 35 72717 7087 53269227
Haemoglobin decreased 19.57 13.52 279 72473 137028 53139286
Neutrophil count abnormal 19.55 13.52 21 72731 2633 53273681
Underdose 19.51 13.52 3 72749 21519 53254795
Acidosis 19.48 13.52 46 72706 11346 53264968
Haematocolpos 19.47 13.52 6 72746 58 53276256
Ocular lymphoma 19.47 13.52 6 72746 58 53276256
Swollen tongue 19.45 13.52 9 72743 31071 53245243
Restlessness 19.41 13.52 7 72745 28080 53248234
Delayed puberty 19.40 13.52 7 72745 114 53276200
Iris atrophy 19.38 13.52 6 72746 59 53276255
Dysgeusia 19.33 13.52 18 72734 42913 53233401
Tremor 19.25 13.52 97 72655 125639 53150675
Quadriparesis 19.23 13.52 18 72734 1913 53274401
Amnesia 19.22 13.52 20 72732 45268 53231046
Osteoporosis 19.18 13.52 21 72731 46439 53229875
Cerebral artery thrombosis 19.08 13.52 10 72742 414 53275900
Rectal adenoma 19.03 13.52 6 72746 63 53276251
Hypoglycaemia 18.98 13.52 32 72720 58981 53217333
Interstitial lung disease 18.98 13.52 141 72611 58481 53217833
Skin ulcer 18.95 13.52 13 72739 36106 53240208
Foot fracture 18.92 13.52 3 72749 21036 53255278
Rectal fissure 18.91 13.52 11 72741 560 53275754
Enteral nutrition 18.86 13.52 6 72746 65 53276249
Neurological decompensation 18.85 13.52 20 72732 2472 53273842
Primary mediastinal large B-cell lymphoma recurrent 18.77 13.52 6 72746 66 53276248
Adverse event 18.74 13.52 17 72735 41044 53235270
Hepatosplenomegaly 18.68 13.52 20 72732 2498 53273816
Anaesthesia 18.63 13.52 10 72742 435 53275879
Leukaemic infiltration 18.60 13.52 5 72747 28 53276286
Inflammatory myofibroblastic tumour 18.60 13.52 5 72747 28 53276286
Gastrointestinal disorder 18.42 13.52 62 72690 89942 53186372
Tracheo-oesophageal fistula 18.42 13.52 11 72741 588 53275726
Illness 18.42 13.52 4 72748 22392 53253922
Lipase increased 18.41 13.52 40 72712 9338 53266976
Meningoencephalitis herpetic 18.35 13.52 14 72738 1124 53275190
Oedema due to cardiac disease 18.31 13.52 5 72747 30 53276284
Coronavirus infection 18.29 13.52 22 72730 3118 53273196
Vulvovaginitis 18.26 13.52 9 72743 327 53275987
Enterococcus test positive 18.16 13.52 14 72738 1141 53275173
Heart rate irregular 18.12 13.52 3 72749 20381 53255933
Peripheral sensorimotor neuropathy 18.07 13.52 15 72737 1360 53274954
Gastrointestinal toxicity 17.97 13.52 27 72725 4735 53271579
Acute leukaemia 17.94 13.52 14 72738 1162 53275152
Blood immunoglobulin A decreased 17.86 13.52 9 72743 343 53275971
Vulvovaginal inflammation 17.84 13.52 11 72741 623 53275691
Hypophosphataemia 17.79 13.52 38 72714 8767 53267547
Endocarditis 17.78 13.52 29 72723 5455 53270859
Abdominal compartment syndrome 17.76 13.52 11 72741 628 53275686
SARS-CoV-2 test negative 17.72 13.52 9 72743 349 53275965
Papillary thyroid cancer 17.67 13.52 18 72734 2122 53274192
Adenovirus infection 17.62 13.52 22 72730 3240 53273074
Staphylococcus test positive 17.62 13.52 24 72728 3849 53272465
Acute monocytic leukaemia 17.59 13.52 6 72746 82 53276232
Autonomic neuropathy 17.58 13.52 13 72739 995 53275319
Device issue 17.54 13.52 4 72748 21654 53254660
Urinary tract infection bacterial 17.53 13.52 26 72726 4508 53271806
Primary cardiac lymphoma 17.52 13.52 5 72747 36 53276278
Cardiac disorder 17.50 13.52 23 72729 46943 53229371
Chronic hepatitis B 17.43 13.52 8 72744 247 53276067
Myeloproliferative neoplasm 17.43 13.52 10 72742 496 53275818
Blood magnesium decreased 17.34 13.52 45 72707 11769 53264545
Pyloric stenosis 17.30 13.52 9 72743 367 53275947
Splenic necrosis 17.17 13.52 5 72747 39 53276275
Candida sepsis 17.14 13.52 15 72737 1461 53274853
Pulmonary vascular disorder 17.10 13.52 9 72743 376 53275938
Precursor T-lymphoblastic lymphoma/leukaemia 17.06 13.52 5 72747 40 53276274
Postictal state 17.04 13.52 13 72739 1043 53275271
Ear infection 17.00 13.52 7 72745 25893 53250421
Listeria encephalitis 16.97 13.52 8 72744 263 53276051
Hyporeflexia 16.97 13.52 17 72735 1965 53274349
C-reactive protein abnormal 16.96 13.52 7 72745 25863 53250451
Bacillus test positive 16.96 13.52 5 72747 41 53276273
Hyperkalaemia 16.92 13.52 30 72722 54226 53222088
Myelitis 16.89 13.52 14 72738 1267 53275047
Haemangioma-thrombocytopenia syndrome 16.80 13.52 3 72749 0 53276314
Bone marrow leukaemic cell infiltration 16.80 13.52 3 72749 0 53276314
Blast crisis in myelogenous leukaemia 16.79 13.52 10 72742 532 53275782
Chromosomal deletion 16.64 13.52 5 72747 44 53276270
Urethritis 16.64 13.52 8 72744 275 53276039
Flagellate dermatitis 16.63 13.52 7 72745 175 53276139
Astrocytoma 16.61 13.52 6 72746 98 53276216
Diffuse large B-cell lymphoma stage IV 16.59 13.52 8 72744 277 53276037
Aborted pregnancy 16.54 13.52 5 72747 45 53276269
Pancreatitis acute 16.49 13.52 75 72677 26034 53250280
Coronary artery disease 16.29 13.52 13 72739 33424 53242890
Subileus 16.28 13.52 21 72731 3195 53273119
Meningism 16.24 13.52 9 72743 417 53275897
Therapy cessation 16.21 13.52 9 72743 28016 53248298
Encopresis 16.18 13.52 6 72746 106 53276208
Tachypnoea 16.15 13.52 53 72699 15801 53260513
Central nervous system leukaemia 16.13 13.52 6 72746 107 53276207
Lymphocytosis 16.06 13.52 18 72734 2365 53273949
Pancreatic pseudocyst 16.02 13.52 10 72742 579 53275735
Beta 2 microglobulin decreased 15.98 13.52 4 72748 16 53276298
Optic glioma 15.98 13.52 4 72748 16 53276298
Perirectal abscess 15.94 13.52 12 72740 944 53275370
Refractory cytopenia with unilineage dysplasia 15.93 13.52 10 72742 585 53275729
B-lymphocyte count abnormal 15.90 13.52 5 72747 52 53276262
Hyperviscosity syndrome 15.86 13.52 7 72745 197 53276117
Erythropenia 15.82 13.52 7 72745 198 53276116
Intestinal dilatation 15.80 13.52 15 72737 1623 53274691
Eye irritation 15.78 13.52 3 72749 18446 53257868
Vascular compression 15.78 13.52 6 72746 114 53276200
Intra-abdominal haemorrhage 15.76 13.52 18 72734 2414 53273900
Swelling face 15.76 13.52 34 72718 57134 53219180
Vaccination failure 15.76 13.52 7 72745 200 53276114
Vertigo 15.75 13.52 33 72719 56048 53220266
Respiratory syncytial virus infection 15.71 13.52 27 72725 5301 53271013
Metastases to peritoneum 15.65 13.52 20 72732 3015 53273299
Tachycardia induced cardiomyopathy 15.65 13.52 5 72747 55 53276259
COVID-19 pneumonia 15.62 13.52 32 72720 7171 53269143
Pericardial effusion 15.51 13.52 76 72676 27202 53249112
Cauda equina syndrome 15.49 13.52 11 72741 791 53275523
Hepatitis B surface antigen positive 15.41 13.52 5 72747 58 53276256
Eosinophilia 15.29 13.52 5 72747 21330 53254984
Porphyria non-acute 15.27 13.52 8 72744 331 53275983
Malignant neoplasm of orbit 15.26 13.52 4 72748 20 53276294
Joint range of motion decreased 15.19 13.52 3 72749 17953 53258361
Respiratory arrest 15.17 13.52 14 72738 33526 53242788
Asthenia 15.12 13.52 355 72397 343235 52933079
Klebsiella test positive 15.12 13.52 12 72740 1021 53275293
Visceral leishmaniasis 15.02 13.52 9 72743 484 53275830
Sopor 15.01 13.52 5 72747 21079 53255235
Adult T-cell lymphoma/leukaemia 14.84 13.52 8 72744 351 53275963
Osmotic demyelination syndrome 14.79 13.52 10 72742 664 53275650
Withdrawal syndrome 14.79 13.52 4 72748 19297 53257017
Pneumonitis 14.76 13.52 82 72670 30806 53245508
Hydrocephalus 14.74 13.52 26 72726 5210 53271104
Rash macular 14.74 13.52 5 72747 20842 53255472
Antithrombin III deficiency 14.72 13.52 3 72749 3 53276311
Ventriculo-peritoneal shunt 14.72 13.52 3 72749 3 53276311
Vulvovaginal adhesion 14.72 13.52 3 72749 3 53276311
Vaginal obstruction 14.72 13.52 3 72749 3 53276311
Pancreatic infarction 14.72 13.52 3 72749 3 53276311
Heart rate increased 14.69 13.52 60 72692 82255 53194059
Chronic graft versus host disease 14.68 13.52 20 72732 3208 53273106
Cheyne-Stokes respiration 14.67 13.52 6 72746 139 53276175
Febrile infection 14.67 13.52 13 72739 1288 53275026
Liver function test abnormal 14.61 13.52 27 72725 48044 53228270
Cranial nerve disorder 14.53 13.52 8 72744 366 53275948
Malnutrition 14.51 13.52 49 72703 14822 53261492
Gastroenteritis salmonella 14.45 13.52 9 72743 519 53275795
Neonatal respiratory distress 14.44 13.52 7 72745 245 53276069
Electrocardiogram QT prolonged 14.37 13.52 35 72717 56368 53219946
Streptococcal bacteraemia 14.33 13.52 14 72738 1570 53274744
Anal ulcer 14.31 13.52 9 72743 528 53275786
Intervertebral disc protrusion 14.29 13.52 6 72746 21939 53254375
Shock 14.27 13.52 66 72686 23073 53253241
Eyelid ptosis 14.25 13.52 29 72723 6468 53269846
Acute graft versus host disease 14.23 13.52 23 72729 4294 53272020
Amenorrhoea 14.12 13.52 36 72716 9313 53267001
Ocular hyperaemia 14.12 13.52 6 72746 21785 53254529
Osteosarcoma 14.10 13.52 6 72746 154 53276160
Gastrointestinal inflammation 14.08 13.52 24 72728 4682 53271632
Brain herniation 14.07 13.52 20 72732 3336 53272978
Fungal test positive 14.05 13.52 9 72743 545 53275769
Peripheral T-cell lymphoma unspecified 14.03 13.52 7 72745 261 53276053
Sciatica 14.01 13.52 6 72746 21687 53254627
Cancer in remission 13.99 13.52 4 72748 29 53276285
Ecthyma 13.96 13.52 7 72745 264 53276050
Iron deficiency anaemia 13.96 13.52 4 72748 18576 53257738
Upper limb fracture 13.94 13.52 3 72749 16904 53259410
Dysaesthesia 13.91 13.52 22 72730 4033 53272281
Breast cancer 13.90 13.52 29 72723 49329 53226985
Viral haemorrhagic cystitis 13.80 13.52 10 72742 742 53275572
Sarcoidosis 13.78 13.52 26 72726 5488 53270826
Drug dependence 13.77 13.52 6 72746 21466 53254848
Encephalitis cytomegalovirus 13.76 13.52 9 72743 565 53275749
Enterocolitis 13.75 13.52 30 72722 7022 53269292
Bacillus infection 13.75 13.52 9 72743 566 53275748
Human herpesvirus 7 infection 13.71 13.52 5 72747 84 53276230
Eye pain 13.69 13.52 13 72739 30712 53245602
Otitis media acute 13.68 13.52 11 72741 953 53275361
Meningitis coccidioides 13.65 13.52 4 72748 32 53276282
Listeriosis 13.64 13.52 13 72739 1414 53274900
Obliterative bronchiolitis 13.61 13.52 15 72737 1935 53274379
Injection site rash 13.55 13.52 3 72749 16576 53259738
Campylobacter infection 13.54 13.52 10 72742 764 53275550
Fusobacterium infection 13.54 13.52 4 72748 33 53276281

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 4167.55 12.98 3144 91435 116422 32302525
Neutropenia 1500.13 12.98 1950 92629 140225 32278722
Hepatitis B 687.36 12.98 346 94233 5995 32412952
Mucosal inflammation 666.54 12.98 641 93938 32793 32386154
Product use in unapproved indication 642.20 12.98 1010 93569 86194 32332753
Second primary malignancy 568.32 12.98 314 94265 6627 32412320
Febrile bone marrow aplasia 561.23 12.98 333 94246 8082 32410865
Diffuse large B-cell lymphoma recurrent 554.54 12.98 228 94351 2394 32416553
Bone marrow failure 522.88 12.98 538 94041 29866 32389081
Myelodysplastic syndrome 510.49 12.98 441 94138 19597 32399350
Myelosuppression 484.63 12.98 343 94236 11333 32407614
Haematotoxicity 461.95 12.98 272 94307 6504 32412443
Posterior reversible encephalopathy syndrome 441.27 12.98 300 94279 9276 32409671
Hepatitis B reactivation 438.91 12.98 210 94369 3239 32415708
Pancytopenia 435.05 12.98 874 93705 90361 32328586
Tumour lysis syndrome 434.40 12.98 351 94228 14196 32404751
Diffuse large B-cell lymphoma 423.33 12.98 279 94300 8183 32410764
Venoocclusive liver disease 418.24 12.98 263 94316 7102 32411845
Acute myeloid leukaemia 401.65 12.98 378 94201 18796 32400151
Hypofibrinogenaemia 325.17 12.98 138 94441 1578 32417369
Pyrexia 324.66 12.98 1804 92775 318164 32100783
Progressive multifocal leukoencephalopathy 308.12 12.98 241 94338 9290 32409657
Fall 280.75 12.98 110 94469 196091 32222856
Sepsis 269.24 12.98 1042 93537 157792 32261155
Thrombocytopenia 268.79 12.98 994 93585 147305 32271642
Pneumocystis jirovecii pneumonia 263.04 12.98 299 94280 18571 32400376
Off label use 260.12 12.98 1649 92930 304671 32114276
Leukopenia 254.66 12.98 549 94030 59573 32359374
Acute lymphocytic leukaemia 247.09 12.98 144 94435 3374 32415573
Product dose omission issue 245.08 12.98 13 94566 102562 32316385
Acute lymphocytic leukaemia recurrent 237.86 12.98 134 94445 2938 32416009
Neoplasm progression 235.07 12.98 288 94291 19370 32399577
Cytomegalovirus chorioretinitis 233.14 12.98 140 94439 3472 32415475
Septic shock 229.59 12.98 573 94006 68416 32350531
Neuropathy peripheral 228.03 12.98 612 93967 76370 32342577
Neutrophil count decreased 223.60 12.98 451 94128 46688 32372259
Death 217.98 12.98 496 94083 382021 32036926
Diffuse large B-cell lymphoma refractory 213.34 12.98 86 94493 854 32418093
Disease progression 207.33 12.98 639 93940 86223 32332724
Cytopenia 206.09 12.98 196 94383 9868 32409079
Neutropenic sepsis 202.56 12.98 216 94363 12483 32406464
Fatigue 194.65 12.98 461 94118 350240 32068707
Dizziness 193.36 12.98 195 94384 209423 32209524
Arthralgia 187.59 12.98 99 94480 148349 32270598
B-cell lymphoma recurrent 179.08 12.98 69 94510 601 32418346
Rash 178.36 12.98 208 94371 209125 32209822
Acquired gene mutation 177.35 12.98 82 94497 1165 32417782
Myocardial infarction 170.65 12.98 76 94503 125600 32293347
Post transplant lymphoproliferative disorder 162.01 12.98 135 94444 5699 32413248
Leukoencephalopathy 156.97 12.98 115 94464 4010 32414937
Hyperbilirubinaemia 156.70 12.98 224 94355 17506 32401441
Mantle cell lymphoma recurrent 152.80 12.98 57 94522 450 32418497
Dyspnoea 149.19 12.98 547 94032 361498 32057449
Hypogammaglobulinaemia 147.30 12.98 131 94448 6045 32412902
Cardiotoxicity 145.05 12.98 118 94461 4814 32414133
White blood cell count decreased 145.04 12.98 587 93992 90611 32328336
Hypertriglyceridaemia 143.83 12.98 151 94428 8568 32410379
Pain 141.52 12.98 204 94375 187352 32231595
Insomnia 140.47 12.98 58 94521 100290 32318657
Neoplasm recurrence 139.04 12.98 82 94497 1965 32416982
Muscle spasms 138.49 12.98 20 94559 70398 32348549
Peripheral swelling 133.05 12.98 20 94559 68325 32350622
Joint swelling 132.10 12.98 4 94575 51731 32367216
Anxiety 131.95 12.98 57 94522 95948 32322999
Therapy partial responder 130.54 12.98 111 94468 4819 32414128
Aspergillus infection 129.42 12.98 164 94415 11410 32407537
Rhabdomyolysis 127.96 12.98 21 94558 67244 32351703
Pruritus 126.38 12.98 113 94466 128589 32290358
Neurotoxicity 125.32 12.98 185 94394 14885 32404062
Bacteraemia 124.93 12.98 201 94378 17432 32401515
Depression 123.60 12.98 64 94515 96996 32321951
Overdose 122.39 12.98 50 94529 87027 32331920
Lymphadenopathy 117.64 12.98 250 94329 26832 32392115
Malaise 117.28 12.98 210 94369 176928 32242019
Lymphopenia 113.83 12.98 173 94406 14283 32404664
Rheumatoid arthritis 111.75 12.98 4 94575 44540 32374407
Disease recurrence 110.92 12.98 181 94398 15883 32403064
Central nervous system lymphoma 110.55 12.98 55 94524 927 32418020
Osteonecrosis 110.35 12.98 184 94395 16438 32402509
Polyneuropathy 109.55 12.98 162 94417 13053 32405894
Hepatic failure 107.86 12.98 286 94293 35394 32383553
Weight increased 106.76 12.98 55 94524 83608 32335339
Candida infection 104.93 12.98 181 94398 16622 32402325
Stomatitis 104.38 12.98 305 94274 39924 32379023
Epstein-Barr virus infection 103.30 12.98 115 94464 6975 32411972
Malignant neoplasm progression 100.86 12.98 474 94105 78022 32340925
Myelopathy 100.68 12.98 67 94512 1996 32416951
Inappropriate schedule of product administration 100.12 12.98 9 94570 45816 32373131
Feeling abnormal 98.30 12.98 27 94552 60396 32358551
Suicidal ideation 97.02 12.98 3 94576 38080 32380867
Somnolence 96.16 12.98 96 94483 103701 32315246
Myalgia 95.59 12.98 59 94520 81171 32337776
B-cell lymphoma 94.63 12.98 90 94489 4529 32414418
Venoocclusive disease 94.32 12.98 72 94507 2674 32416273
Hospitalisation 93.77 12.98 15 94564 48956 32369991
Coronary artery disease 93.46 12.98 16 94563 49690 32369257
Psoriasis 93.28 12.98 12 94567 46111 32372836
Sweat gland tumour 89.75 12.98 37 94542 391 32418556
Hallucination 88.48 12.98 22 94557 52597 32366350
Cerebrovascular accident 88.08 12.98 73 94506 86247 32332700
Aplasia 86.19 12.98 84 94495 4358 32414589
Cytokine release syndrome 84.77 12.98 146 94433 13389 32405558
Blood fibrinogen decreased 83.96 12.98 47 94532 1017 32417930
Platelet count decreased 83.45 12.98 595 93984 113996 32304951
Drug resistance 82.94 12.98 197 94382 22768 32396179
Intentional product misuse 81.76 12.98 6 94573 36045 32382902
Asthma 81.07 12.98 15 94564 44050 32374897
Herpes simplex 80.72 12.98 87 94492 5087 32413860
Cardiac failure congestive 80.28 12.98 77 94502 84775 32334172
Ileus paralytic 80.26 12.98 93 94486 5893 32413054
Nasopharyngitis 79.79 12.98 43 94536 63744 32355203
Cytomegalovirus infection 78.87 12.98 206 94373 25258 32393689
Drug interaction 78.60 12.98 347 94232 217838 32201109
Diarrhoea 77.10 12.98 685 93894 364117 32054830
Chronic obstructive pulmonary disease 77.06 12.98 23 94556 48730 32370217
Infection 76.94 12.98 465 94114 84250 32334697
Haemophagocytic lymphohistiocytosis 75.94 12.98 126 94453 11209 32407738
Aggression 75.56 12.98 12 94567 39377 32379570
Suicide attempt 74.85 12.98 11 94568 38233 32380714
Blood glucose increased 74.54 12.98 49 94530 65192 32353755
Chest pain 74.40 12.98 156 94423 123981 32294966
Tremor 74.31 12.98 76 94503 81201 32337746
Adenovirus infection 73.21 12.98 79 94500 4625 32414322
Hyperhidrosis 72.83 12.98 60 94519 71108 32347839
Blood culture positive 72.07 12.98 81 94498 4964 32413983
Cerebral venous thrombosis 71.92 12.98 36 94543 615 32418332
Fungal infection 71.12 12.98 145 94434 15110 32403837
Multiple organ dysfunction syndrome 70.95 12.98 395 94184 69459 32349488
Blood creatine phosphokinase increased 70.88 12.98 22 94557 45454 32373493
Confusional state 70.67 12.98 199 94380 142916 32276031
Colitis 70.20 12.98 238 94341 33713 32385234
Blood pressure increased 69.42 12.98 77 94502 79277 32339670
Enterovirus infection 67.45 12.98 35 94544 647 32418300
Bronchopulmonary aspergillosis 67.28 12.98 133 94446 13554 32405393
Lymphoma 66.98 12.98 116 94463 10684 32408263
Neutropenic colitis 65.99 12.98 57 94522 2528 32416419
Escherichia sepsis 65.89 12.98 72 94507 4276 32414671
Hepatotoxicity 64.62 12.98 161 94418 19176 32399771
Incorrect dose administered 64.27 12.98 12 94567 35016 32383931
Oedema peripheral 63.73 12.98 149 94430 113942 32305005
West Nile viral infection 63.31 12.98 33 94546 616 32418331
Mucormycosis 63.02 12.98 80 94499 5574 32413373
Agranulocytosis 62.81 12.98 180 94399 23297 32395650
Memory impairment 62.34 12.98 20 94559 40459 32378488
Bacterial sepsis 62.19 12.98 77 94502 5231 32413716
Epstein-Barr virus associated lymphoproliferative disorder 61.74 12.98 48 94531 1832 32417115
Systemic mycosis 61.39 12.98 43 94536 1395 32417552
Injection site pain 61.35 12.98 11 94568 33047 32385900
Superior sagittal sinus thrombosis 61.35 12.98 26 94553 296 32418651
Chest discomfort 59.75 12.98 36 94543 50194 32368753
Cytogenetic abnormality 59.40 12.98 35 94544 837 32418110
Hypoglycaemia 59.25 12.98 43 94536 54339 32364608
Asthenia 58.98 12.98 423 94156 235521 32183426
Back pain 58.90 12.98 149 94430 110904 32308043
Cerebral venous sinus thrombosis 58.68 12.98 27 94552 379 32418568
Stem cell transplant 58.67 12.98 50 94529 2177 32416770
Multiple-drug resistance 58.05 12.98 63 94516 3712 32415235
Acute lymphocytic leukaemia refractory 57.61 12.98 19 94560 99 32418848
Plasmablastic lymphoma 57.60 12.98 25 94554 303 32418644
Minimal residual disease 57.24 12.98 25 94554 308 32418639
Headache 57.00 12.98 336 94243 195861 32223086
Adenoviral hepatitis 56.91 12.98 23 94556 230 32418717
Stress 56.79 12.98 3 94576 23779 32395168
Oesophageal stenosis 56.60 12.98 44 94535 1679 32417268
Antithrombin III decreased 56.13 12.98 26 94553 371 32418576
Pain in extremity 56.01 12.98 169 94410 118732 32300215
JC virus infection 55.57 12.98 46 94533 1923 32417024
Coombs positive haemolytic anaemia 55.53 12.98 33 94546 802 32418145
Pseudomonas infection 54.32 12.98 113 94466 11943 32407004
Gait disturbance 54.31 12.98 94 94485 80314 32338633
Loss of personal independence in daily activities 54.20 12.98 7 94572 26826 32392121
Pleural effusion 53.92 12.98 404 94175 78588 32340359
Pneumonitis 53.53 12.98 201 94378 29933 32389014
Malignant transformation 53.37 12.98 32 94547 791 32418156
Gastritis bacterial 53.23 12.98 21 94558 196 32418751
Staphylococcal sepsis 53.22 12.98 100 94479 9813 32409134
Musculoskeletal stiffness 52.82 12.98 24 94555 39240 32379707
Strongyloidiasis 52.65 12.98 50 94529 2511 32416436
Anaemia 52.26 12.98 927 93652 222697 32196250
Leukaemia recurrent 52.00 12.98 41 94538 1598 32417349
Drug hypersensitivity 51.24 12.98 84 94495 73316 32345631
Wrong technique in product usage process 51.09 12.98 19 94560 35040 32383907
Respiratory failure 51.00 12.98 506 94073 106676 32312271
Arthropathy 50.26 12.98 4 94575 22485 32396462
Inappropriate antidiuretic hormone secretion 49.66 12.98 109 94470 11954 32406993
Aspiration bone marrow abnormal 49.55 12.98 17 94562 102 32418845
Glioma 49.17 12.98 23 94556 336 32418611
Infection reactivation 48.00 12.98 34 94545 1123 32417824
Device related infection 47.49 12.98 137 94442 17796 32401151
Balance disorder 47.32 12.98 28 94551 39431 32379516
Cystitis haemorrhagic 47.22 12.98 66 94513 5048 32413899
Abdominal discomfort 47.19 12.98 50 94529 52574 32366373
Syncope 46.94 12.98 122 94457 90002 32328945
Epstein-Barr virus associated lymphoma 46.88 12.98 27 94552 618 32418329
Myelitis transverse 46.21 12.98 32 94547 1019 32417928
Wheezing 45.89 12.98 25 94554 36849 32382098
Hepatosplenic candidiasis 45.57 12.98 19 94560 207 32418740
Escherichia bacteraemia 45.21 12.98 51 94528 3138 32415809
Peripheral motor neuropathy 45.20 12.98 39 94540 1727 32417220
Hyperkalaemia 44.89 12.98 84 94495 69666 32349281
Viral haemorrhagic cystitis 44.74 12.98 30 94549 905 32418042
Bone marrow necrosis 44.74 12.98 17 94562 142 32418805
Coagulopathy 44.73 12.98 142 94437 19435 32399512
Intussusception 44.45 12.98 25 94554 546 32418401
Peripheral T-cell lymphoma unspecified 44.21 12.98 25 94554 552 32418395
Hepatomegaly 43.63 12.98 95 94484 10362 32408585
Central nervous system leukaemia 43.51 12.98 20 94559 280 32418667
Sleep disorder 43.41 12.98 12 94567 26740 32392207
Disseminated intravascular coagulation 43.18 12.98 157 94422 23019 32395928
Loss of consciousness 43.04 12.98 112 94467 82595 32336352
Nausea 42.95 12.98 666 93913 320183 32098764
Unevaluable event 42.93 12.98 22 94557 33564 32385383
Lymphadenitis 42.29 12.98 38 94541 1777 32417170
Sedation 42.24 12.98 3 94576 18523 32400424
Injury 42.16 12.98 7 94572 22238 32396709
Mobility decreased 42.07 12.98 15 94564 28394 32390553
Gastrointestinal toxicity 42.05 12.98 41 94538 2128 32416819
Klebsiella infection 41.99 12.98 80 94499 7932 32411015
Therapy non-responder 41.75 12.98 197 94382 32457 32386490
Product quality issue 41.41 12.98 4 94575 19229 32399718
Recurrent cancer 41.37 12.98 32 94547 1212 32417735
Cardiomyopathy 41.12 12.98 121 94458 15892 32403055
Serotonin syndrome 41.10 12.98 4 94575 19113 32399834
Treatment noncompliance 40.90 12.98 14 94565 27188 32391759
Weight decreased 40.87 12.98 296 94283 164522 32254425
Lung infiltration 40.85 12.98 106 94473 12942 32406005
End stage renal disease 40.59 12.98 79 94500 7958 32410989
Refractory anaemia with an excess of blasts 39.63 12.98 21 94558 406 32418541
Nephrolithiasis 39.56 12.98 15 94564 27339 32391608
Neuroleptic malignant syndrome 39.41 12.98 3 94576 17492 32401455
Escherichia infection 39.40 12.98 73 94506 7087 32411860
Lymphoma transformation 39.33 12.98 16 94563 163 32418784
Pneumonia aspiration 39.31 12.98 37 94542 41119 32377828
Systemic candida 38.94 12.98 46 94533 2975 32415972
Blood pressure fluctuation 38.92 12.98 6 94573 20129 32398818
Central nervous system neoplasm 38.61 12.98 13 94566 73 32418874
Primitive neuroectodermal tumour 38.61 12.98 13 94566 73 32418874
Contusion 38.40 12.98 25 94554 33443 32385504
Encephalopathy 38.34 12.98 199 94380 34058 32384889
Respiratory distress 38.25 12.98 203 94376 35043 32383904
Congenital cardiovascular anomaly 37.69 12.98 16 94563 183 32418764
Drug reaction with eosinophilia and systemic symptoms 37.63 12.98 24 94555 32461 32386486
Dry skin 37.31 12.98 13 94566 24965 32393982
International normalised ratio increased 37.21 12.98 53 94526 48982 32369965
Encephalitis enteroviral 37.20 12.98 15 94564 149 32418798
Pulmonary vascular disorder 37.02 12.98 23 94556 607 32418340
Optic glioma 36.73 12.98 11 94568 39 32418908
Adverse event 36.61 12.98 3 94576 16469 32402478
Haemolysis 36.57 12.98 74 94505 7667 32411280
Atrial fibrillation 36.48 12.98 195 94384 116509 32302438
Depressed mood 36.42 12.98 5 94574 18295 32400652
B-cell lymphoma refractory 36.03 12.98 14 94565 125 32418822
Pneumocystis jirovecii infection 35.98 12.98 32 94547 1476 32417471
Abdominal pain upper 35.95 12.98 90 94489 67248 32351699
Hepatosplenomegaly 35.49 12.98 50 94529 3853 32415094
Bone marrow disorder 35.29 12.98 33 94546 1625 32417322
Juvenile melanoma benign 35.26 12.98 12 94567 70 32418877
Chronic lymphocytic leukaemia refractory 35.14 12.98 13 94566 100 32418847
Pulmonary arteriopathy 34.97 12.98 12 94567 72 32418875
Ejection fraction decreased 34.93 12.98 122 94457 17536 32401411
Bradycardia 34.91 12.98 100 94479 71462 32347485
T-cell type acute leukaemia 34.84 12.98 15 94564 178 32418769
Heart rate decreased 34.52 12.98 15 94564 25185 32393762
Fluid retention 34.52 12.98 17 94562 26533 32392414
Acute myelomonocytic leukaemia 34.46 12.98 14 94565 142 32418805
Abnormal behaviour 34.33 12.98 17 94562 26449 32392498
Haematochezia 34.32 12.98 38 94541 39170 32379777
Blood stem cell transplant failure 34.19 12.98 19 94560 405 32418542
Peripheral sensory neuropathy 34.08 12.98 65 94514 6449 32412498
Intestinal perforation 34.08 12.98 78 94501 8797 32410150
Retinal haemorrhage 33.88 12.98 56 94523 4965 32413982
Cardio-respiratory arrest 33.80 12.98 70 94509 55919 32363028
Staphylococcal bacteraemia 33.59 12.98 70 94509 7406 32411541
Body height below normal 33.59 12.98 16 94563 244 32418703
T-cell lymphoma 33.36 12.98 26 94553 996 32417951
Haemoglobin abnormal 33.03 12.98 45 94534 3360 32415587
Electrocardiogram QT prolonged 32.99 12.98 40 94539 39601 32379346
Adverse drug reaction 32.96 12.98 17 94562 25844 32393103
Influenza 32.72 12.98 52 94527 45962 32372985
Rhabdomyosarcoma recurrent 32.70 12.98 12 94567 90 32418857
Hypersensitivity 32.57 12.98 75 94504 57683 32361264
Xanthogranuloma 32.45 12.98 10 94569 40 32418907
Bacterial infection 32.37 12.98 102 94477 13904 32405043
Nervous system disorder 32.18 12.98 102 94477 13947 32405000
Neuroblastoma 32.13 12.98 15 94564 218 32418729
Pneumonia fungal 32.04 12.98 62 94517 6218 32412729
Gene mutation 32.00 12.98 25 94554 961 32417986
Pulmonary toxicity 31.76 12.98 54 94525 4899 32414048
Injection site erythema 31.71 12.98 3 94576 14665 32404282
Blood creatinine increased 31.52 12.98 158 94421 95974 32322973
Hereditary motor and sensory neuropathy 31.45 12.98 8 94571 12 32418935
Palpitations 31.33 12.98 35 94544 35934 32383013
Ganglioneuroblastoma 31.19 12.98 9 94570 27 32418920
Gastrooesophageal reflux disease 31.14 12.98 33 94546 34705 32384242
Acute promyelocytic leukaemia 30.83 12.98 20 94559 570 32418377
Acute monocytic leukaemia 30.69 12.98 17 94562 360 32418587
B-cell type acute leukaemia 30.30 12.98 16 94563 307 32418640
Autoimmune lymphoproliferative syndrome 30.22 12.98 13 94566 154 32418793
Agitation 30.16 12.98 77 94502 57159 32361788
Cardiac disorder 30.07 12.98 47 94532 41819 32377128
Plasma cell myeloma 29.98 12.98 78 94501 57536 32361411
Mass 29.97 12.98 68 94511 7624 32411323
Astrocytoma 29.90 12.98 14 94565 205 32418742
Transformation to acute myeloid leukaemia 29.88 12.98 21 94558 685 32418262
Amnesia 29.68 12.98 18 94561 25018 32393929
Sleep apnoea syndrome 29.49 12.98 9 94570 18805 32400142
Hot flush 29.48 12.98 5 94574 15641 32403306
Subdural hygroma 29.44 12.98 16 94563 326 32418621
Pseudomonal sepsis 29.33 12.98 40 94539 2989 32415958
Varicella zoster virus infection 29.32 12.98 29 94550 1532 32417415
Human rhinovirus test positive 29.14 12.98 13 94566 169 32418778
Musculoskeletal pain 28.93 12.98 30 94549 31867 32387080
Neurofibrosarcoma 28.82 12.98 9 94570 38 32418909
Epstein-Barr viraemia 28.77 12.98 24 94555 1014 32417933
Transient ischaemic attack 28.61 12.98 20 94559 25774 32393173
Hepatic infection fungal 28.35 12.98 13 94566 181 32418766
Anal inflammation 28.22 12.98 16 94563 355 32418592
Bone marrow infiltration 28.04 12.98 11 94568 101 32418846
Delayed puberty 27.97 12.98 13 94566 187 32418760
Blood pressure systolic increased 27.86 12.98 8 94571 17388 32401559
Clostridium test positive 27.77 12.98 34 94545 2283 32416664
Prostatic specific antigen increased 27.72 12.98 3 94576 13184 32405763
Chronic kidney disease 27.65 12.98 46 94533 39929 32379018
Small intestinal perforation 27.62 12.98 30 94549 1769 32417178
Pneumonia viral 27.33 12.98 38 94541 2892 32416055
Psoriatic arthropathy 27.19 12.98 9 94570 17851 32401096
BK virus infection 27.15 12.98 50 94529 4831 32414116
Chronic lymphocytic leukaemia 27.12 12.98 50 94529 4835 32414112
Mantle cell lymphoma 27.06 12.98 29 94550 1684 32417263
Myocardial ischaemia 26.94 12.98 9 94570 17750 32401197
Gallbladder oedema 26.90 12.98 13 94566 205 32418742
Acute hepatic failure 26.87 12.98 91 94488 12878 32406069
Ewing's sarcoma 26.79 12.98 8 94571 28 32418919
Dysgeusia 26.76 12.98 21 94558 25510 32393437
Gastrosplenic fistula 26.58 12.98 8 94571 29 32418918
Influenza like illness 26.39 12.98 24 94555 27116 32391831
High-grade B-cell lymphoma 26.37 12.98 12 94567 164 32418783
Therapy cessation 26.32 12.98 7 94572 16006 32402941
Enterococcal infection 26.29 12.98 72 94507 9075 32409872
Traumatic lung injury 26.23 12.98 25 94554 1261 32417686
Hepatic candidiasis 26.23 12.98 9 94570 54 32418893
Blood glucose decreased 26.23 12.98 4 94575 13530 32405417
Hepatocellular injury 26.23 12.98 144 94435 25174 32393773
Cerebral thrombosis 26.16 12.98 22 94557 940 32418007
Rash pruritic 26.10 12.98 20 94559 24591 32394356
Vision blurred 26.03 12.98 56 94523 44130 32374817
Decreased appetite 26.02 12.98 321 94258 160492 32258455
Glioblastoma multiforme 26.01 12.98 21 94558 847 32418100
Dyspepsia 25.80 12.98 35 94544 33020 32385927
Clostridium difficile colitis 25.78 12.98 96 94483 14235 32404712
Labelled drug-drug interaction medication error 25.65 12.98 3 94576 12410 32406537
Oesophageal candidiasis 25.55 12.98 46 94533 4368 32414579
Diffuse large B-cell lymphoma stage III 25.43 12.98 9 94570 60 32418887
Vertigo 25.41 12.98 20 94559 24263 32394684
Erectile dysfunction 25.34 12.98 13 94566 19826 32399121
Psychotic disorder 25.33 12.98 18 94561 23002 32395945
Drug clearance decreased 25.28 12.98 26 94553 1439 32417508
Lymphocytosis 25.26 12.98 31 94548 2086 32416861
Cellulitis gangrenous 25.19 12.98 12 94567 183 32418764
Splenic lesion 25.08 12.98 11 94568 137 32418810
Rhabdomyosarcoma 25.06 12.98 9 94570 63 32418884
Transaminases increased 25.03 12.98 141 94438 24887 32394060
Delirium 24.99 12.98 57 94522 43989 32374958
Rib fracture 24.96 12.98 5 94574 13884 32405063
Withdrawal syndrome 24.88 12.98 3 94576 12119 32406828
Ascites 24.87 12.98 201 94378 39990 32378957
Herpes simplex encephalitis 24.72 12.98 14 94565 310 32418637
Thymus enlargement 24.70 12.98 9 94570 66 32418881
Clostridium difficile infection 24.70 12.98 110 94469 17686 32401261
Left ventricular dysfunction 24.64 12.98 73 94506 9622 32409325
Burning sensation 24.59 12.98 10 94569 17468 32401479
Cytomegalovirus infection reactivation 24.58 12.98 39 94540 3340 32415607
Interstitial lung disease 24.47 12.98 293 94286 64708 32354239
Medulloblastoma recurrent 24.47 12.98 9 94570 68 32418879
Renal impairment 24.33 12.98 162 94417 91810 32327137
Pneumatosis intestinalis 24.23 12.98 39 94540 3381 32415566
Restlessness 24.19 12.98 22 94557 24859 32394088
Alanine aminotransferase increased 24.19 12.98 341 94238 78138 32340809
Splenic marginal zone lymphoma 24.05 12.98 8 94571 43 32418904
Intestinal atresia 24.02 12.98 9 94570 72 32418875
Angioedema 23.96 12.98 43 94536 36246 32382701
Toxicity to various agents 23.93 12.98 369 94210 177672 32241275
Gastrointestinal necrosis 23.90 12.98 39 94540 3420 32415527
Device related thrombosis 23.90 12.98 21 94558 953 32417994
Hallucination, visual 23.85 12.98 10 94569 17149 32401798
Eczema 23.78 12.98 7 94572 14973 32403974
Liver function test abnormal 23.77 12.98 35 94544 31912 32387035
Erythema 23.72 12.98 143 94436 82962 32335985
Faeces discoloured 23.53 12.98 7 94572 14870 32404077
Peritonitis bacterial 23.53 12.98 4 94575 12492 32406455
Azoospermia 23.52 12.98 15 94564 415 32418532
Haemorrhage 23.45 12.98 70 94509 49378 32369569
Rhinovirus infection 23.27 12.98 38 94541 3335 32415612
Flushing 23.26 12.98 34 94545 31093 32387854
Blood lactate dehydrogenase increased 23.25 12.98 125 94454 21680 32397267
Metastases to bone marrow 23.23 12.98 16 94563 505 32418442
Arthritis 23.21 12.98 26 94553 26666 32392281
Intestinal pseudo-obstruction 23.21 12.98 24 94555 1337 32417610
Delusion 22.98 12.98 5 94574 13103 32405844
Facial paresis 22.96 12.98 35 94544 2896 32416051
Cardiac arrest 22.91 12.98 176 94403 96600 32322347
Chronic myeloid leukaemia 22.88 12.98 34 94545 2750 32416197
Diffuse large B-cell lymphoma stage IV 22.79 12.98 13 94566 292 32418655
Enterocolitis infectious 22.79 12.98 23 94556 1245 32417702
Congenital herpes simplex infection 22.78 12.98 8 94571 52 32418895
Pseudomonal bacteraemia 22.77 12.98 21 94558 1016 32417931
Ameloblastoma 22.72 12.98 9 94570 85 32418862
Loss of CAR T-cell persistence 22.72 12.98 7 94572 28 32418919
Pseudomonas test positive 22.68 12.98 21 94558 1021 32417926
Cerebral salt-wasting syndrome 22.65 12.98 8 94571 53 32418894
Refractory cancer 22.63 12.98 10 94569 127 32418820
Localised infection 22.51 12.98 8 94571 15179 32403768
Skin exfoliation 22.44 12.98 24 94555 25133 32393814
Rectal haemorrhage 22.40 12.98 47 94532 37376 32381571
Lower respiratory tract infection fungal 22.39 12.98 17 94562 626 32418321
Positron emission tomogram abnormal 22.35 12.98 10 94569 131 32418816
Cerebral aspergillosis 22.25 12.98 24 94555 1404 32417543
Hepatitis 22.07 12.98 131 94448 23562 32395385
Escherichia test positive 22.02 12.98 22 94557 1176 32417771
Mucosal infection 22.01 12.98 12 94567 246 32418701
Gastrointestinal haemorrhage 22.00 12.98 155 94424 86727 32332220
Anger 22.00 12.98 4 94575 11900 32407047
Disturbance in attention 21.93 12.98 22 94557 23731 32395216
Pneumoperitoneum 21.63 12.98 27 94552 1849 32417098
Genotoxicity 21.63 12.98 7 94572 34 32418913
Paraplegia 21.62 12.98 33 94546 2733 32416214
Renal salt-wasting syndrome 21.44 12.98 10 94569 145 32418802
Stomatococcal infection 21.44 12.98 10 94569 145 32418802
Blastic plasmacytoid dendritic cell neoplasia 21.43 12.98 9 94570 100 32418847
Orthostatic hypotension 21.22 12.98 26 94553 25624 32393323
Acute lung injury 21.19 12.98 23 94556 1355 32417592
Molluscum contagiosum 21.18 12.98 12 94567 266 32418681
Central nervous system fungal infection 21.10 12.98 13 94566 338 32418609
Bronchitis 20.98 12.98 57 94522 41450 32377497
Granulocyte count decreased 20.94 12.98 17 94562 691 32418256
Focal nodular hyperplasia 20.90 12.98 10 94569 154 32418793
Disorientation 20.84 12.98 41 94538 33384 32385563
Hepatitis viral 20.71 12.98 16 94563 605 32418342
Ileus 20.69 12.98 98 94481 16167 32402780
Administration site extravasation 20.65 12.98 15 94564 516 32418431
Salivary gland cancer 20.63 12.98 12 94567 280 32418667
Blindness cortical 20.60 12.98 13 94566 353 32418594
Vocal cord paralysis 20.47 12.98 19 94560 927 32418020
Hepatic amoebiasis 20.44 12.98 8 94571 73 32418874
Personality change due to a general medical condition 20.40 12.98 7 94572 42 32418905
Metastases to spleen 20.40 12.98 13 94566 359 32418588
Cerebral toxoplasmosis 20.37 12.98 24 94555 1548 32417399
Metastases to retroperitoneum 20.29 12.98 11 94568 223 32418724
Hepatitis D 20.26 12.98 7 94572 43 32418904
Respiratory arrest 20.24 12.98 33 94546 28875 32390072
Accidental exposure to product 20.20 12.98 4 94575 11198 32407749
Acute erythroid leukaemia 20.18 12.98 10 94569 167 32418780
Non-Hodgkin's lymphoma 20.11 12.98 25 94554 1705 32417242
Dermatitis diaper 20.11 12.98 12 94567 294 32418653
Stevens-Johnson syndrome 20.10 12.98 15 94564 18694 32400253
Hypersomnia 20.10 12.98 5 94574 11956 32406991
Haematopoietic stem cell mobilisation 20.07 12.98 10 94569 169 32418778
Vascular access complication 20.07 12.98 11 94568 228 32418719
Sphingomonas paucimobilis infection 19.99 12.98 7 94572 45 32418902
Respiratory tract infection fungal 19.97 12.98 17 94562 739 32418208
Immunosuppression 19.96 12.98 48 94531 5589 32413358
Platelet transfusion 19.95 12.98 20 94559 1074 32417873
Suspected product quality issue 19.92 12.98 10 94569 172 32418775
Retinopathy proliferative 19.88 12.98 8 94571 79 32418868
Parainfluenzae virus infection 19.87 12.98 29 94550 2308 32416639
Morphoea 19.86 12.98 10 94569 173 32418774
Arteriosclerosis 19.77 12.98 4 94575 11030 32407917
Extravasation 19.76 12.98 26 94553 1877 32417070
Diabetic ketoacidosis 19.76 12.98 14 94565 17918 32401029
Periorbital infection 19.71 12.98 9 94570 124 32418823
Limb injury 19.69 12.98 3 94576 10156 32408791
Limb discomfort 19.68 12.98 3 94576 10151 32408796
Osteosarcoma 19.65 12.98 11 94568 238 32418709
Sopor 19.57 12.98 5 94574 11744 32407203
Burkitt's lymphoma 19.56 12.98 10 94569 179 32418768
Lymphoplasmacytoid lymphoma/immunocytoma 19.49 12.98 7 94572 49 32418898
Lactic acidosis 19.34 12.98 43 94536 33493 32385454
Head injury 19.19 12.98 14 94565 17649 32401298
Pulmonary veno-occlusive disease 19.18 12.98 14 94565 485 32418462
Diabetes mellitus inadequate control 19.17 12.98 8 94571 13760 32405187
Microgenia 19.09 12.98 5 94574 9 32418938
Disseminated cryptococcosis 19.05 12.98 20 94559 1134 32417813
Epidermal necrosis 19.03 12.98 14 94565 491 32418456
Neutropenic infection 19.03 12.98 21 94558 1261 32417686
Diffuse large B-cell lymphoma stage II 19.02 12.98 7 94572 53 32418894
Stomatitis necrotising 18.96 12.98 8 94571 90 32418857
Chloroma 18.84 12.98 14 94565 499 32418448
Bone sarcoma 18.81 12.98 8 94571 92 32418855
Hyperpyrexia 18.80 12.98 31 94548 2743 32416204
Vagus nerve paralysis 18.75 12.98 5 94574 10 32418937
Diabetes mellitus 18.63 12.98 68 94511 45105 32373842
Drug eruption 18.57 12.98 17 94562 19149 32399798
Granulocytopenia neonatal 18.56 12.98 6 94573 29 32418918
Marginal zone lymphoma recurrent 18.56 12.98 6 94573 29 32418918
Pneumonia cytomegaloviral 18.53 12.98 32 94547 2940 32416007
Iron deficiency anaemia 18.50 12.98 3 94576 9698 32409249
Condition aggravated 18.48 12.98 330 94249 155331 32263616
Anaplastic large-cell lymphoma 18.43 12.98 10 94569 203 32418744
Basal cell naevus syndrome 18.39 12.98 6 94573 30 32418917
Bacillus test positive 18.39 12.98 6 94573 30 32418917
Streptococcal infection 18.38 12.98 43 94536 4919 32414028
Blood bilirubin increased 18.36 12.98 183 94396 38601 32380346
Dry mouth 18.36 12.98 26 94553 24093 32394854
Lung opacity 18.31 12.98 22 94557 1448 32417499
Plasma cell myeloma refractory 18.26 12.98 7 94572 60 32418887
Abdominal neoplasm 18.26 12.98 10 94569 207 32418740
Phlebitis infective 18.23 12.98 9 94570 149 32418798
Injection site swelling 18.20 12.98 3 94576 9581 32409366
Gastrointestinal inflammation 18.19 12.98 33 94546 3151 32415796
Muscle rigidity 18.18 12.98 5 94574 11181 32407766
Renal tubular disorder 18.10 12.98 44 94535 5158 32413789
Dehydration 18.10 12.98 265 94314 128693 32290254
Extrapyramidal disorder 18.09 12.98 6 94573 11889 32407058
Metastases to muscle 18.09 12.98 10 94569 211 32418736
Humoral immune defect 18.06 12.98 7 94572 62 32418885
Pancreatitis 18.06 12.98 180 94399 37971 32380976
Urinary retention 18.06 12.98 49 94530 35648 32383299
Hallucination, auditory 18.04 12.98 4 94575 10346 32408601
Prescribed overdose 18.03 12.98 3 94576 9516 32409431
Secondary immunodeficiency 17.96 12.98 12 94567 360 32418587
Candida sepsis 17.88 12.98 20 94559 1219 32417728
Urticaria 17.84 12.98 101 94478 59513 32359434
Acute kidney injury 17.82 12.98 686 93893 292782 32126165
Candida endophthalmitis 17.80 12.98 8 94571 106 32418841
Metapneumovirus infection 17.76 12.98 15 94564 645 32418302
Body temperature decreased 17.76 12.98 5 94574 11009 32407938
Pulmonary sarcoidosis 17.64 12.98 14 94565 551 32418396
Obesity 17.61 12.98 4 94575 10178 32408769
Leukaemia 17.53 12.98 37 94542 3949 32414998
Swelling 17.49 12.98 55 94524 38167 32380780
Gastric stenosis 17.49 12.98 6 94573 36 32418911
Infusion site discolouration 17.47 12.98 8 94571 111 32418836
Lymphocytic leukaemia 17.46 12.98 9 94570 164 32418783
Enterovesical fistula 17.41 12.98 15 94564 663 32418284
Irritability 17.39 12.98 28 94551 24626 32394321
Chromosome analysis abnormal 17.34 12.98 8 94571 113 32418834
Injection site reaction 17.31 12.98 6 94573 11563 32407384
Cutaneous T-cell lymphoma recurrent 17.21 12.98 6 94573 38 32418909
Pneumaturia 17.21 12.98 6 94573 38 32418909
Diverticulitis 17.14 12.98 18 94561 19010 32399937
5q minus syndrome 17.08 12.98 9 94570 172 32418775
Skin discolouration 16.99 12.98 14 94565 16599 32402348
Protein S decreased 16.95 12.98 6 94573 40 32418907
Sinusitis bacterial 16.91 12.98 11 94568 315 32418632
Blood cholesterol increased 16.91 12.98 16 94563 17741 32401206
Ocular hyperaemia 16.91 12.98 4 94575 9897 32409050
Neutrophil percentage decreased 16.90 12.98 12 94567 398 32418549
Protein C decreased 16.86 12.98 5 94574 17 32418930
Taeniasis 16.81 12.98 7 94572 76 32418871
Psychomotor hyperactivity 16.78 12.98 3 94576 9036 32409911
Peripheral sensorimotor neuropathy 16.73 12.98 21 94558 1446 32417501
Ototoxicity 16.70 12.98 22 94557 1590 32417357
Therapy responder 16.67 12.98 9 94570 181 32418766
Blood HIV RNA increased 16.64 12.98 22 94557 1595 32417352
Dystrophic calcification 16.61 12.98 4 94575 4 32418943
Heart rate increased 16.57 12.98 64 94515 41764 32377183
Diaphragm muscle weakness 16.56 12.98 8 94571 126 32418821
Type 2 diabetes mellitus 16.51 12.98 12 94567 15160 32403787
Vasogenic cerebral oedema 16.50 12.98 13 94566 506 32418441
Dyspnoea exertional 16.50 12.98 58 94521 38903 32380044
Dyskinesia 16.47 12.98 27 94552 23576 32395371
Peripheral T-cell lymphoma unspecified stage III 16.46 12.98 6 94573 44 32418903
Platelet count abnormal 16.42 12.98 28 94551 2546 32416401
Hypertension 16.38 12.98 277 94302 131473 32287474
Skin toxicity 16.36 12.98 35 94544 3771 32415176
Fungal sepsis 16.35 12.98 17 94562 953 32417994
Mediastinal mass 16.32 12.98 9 94570 189 32418758
Intracranial pressure increased 16.32 12.98 35 94544 3778 32415169
Skin cancer 16.30 12.98 3 94576 8847 32410100
Central nervous system enteroviral infection 16.23 12.98 6 94573 46 32418901
Helicobacter sepsis 16.23 12.98 5 94574 20 32418927
Adenocarcinoma gastric 16.20 12.98 19 94560 1219 32417728
Premature ageing 16.19 12.98 7 94572 84 32418863
Precursor T-lymphoblastic lymphoma/leukaemia 16.19 12.98 7 94572 84 32418863
Urinary bladder rupture 16.19 12.98 7 94572 84 32418863
Klebsiella sepsis 16.12 12.98 23 94556 1793 32417154
B-lymphocyte count decreased 16.11 12.98 13 94566 524 32418423
Proteinuria 16.11 12.98 16 94563 17339 32401608
T-cell lymphoma recurrent 16.01 12.98 6 94573 48 32418899
Cranial nerve disorder 15.92 12.98 12 94567 437 32418510
Bladder cancer 15.91 12.98 5 94574 10251 32408696
Swollen tongue 15.90 12.98 10 94569 13629 32405318
Acinetobacter infection 15.77 12.98 18 94561 1122 32417825
Sinus bradycardia 15.76 12.98 9 94570 12929 32406018
Coma 15.75 12.98 67 94512 42545 32376402
Enterovirus test positive 15.70 12.98 6 94573 51 32418896
Lentigo 15.65 12.98 11 94568 359 32418588
Hepatitis B DNA increased 15.53 12.98 13 94566 552 32418395
Ventricular tachycardia 15.38 12.98 32 94547 25524 32393423
Astrocytoma malignant 15.35 12.98 4 94575 7 32418940
Embolism 15.34 12.98 52 94527 7362 32411585
Fibrosarcoma 15.33 12.98 5 94574 25 32418922
Transplant rejection 15.29 12.98 5 94574 9994 32408953
Refractory cytopenia with multilineage dysplasia 15.27 12.98 8 94571 151 32418796
Exposure during pregnancy 15.23 12.98 4 94575 9225 32409722
Eosinophilia 15.23 12.98 31 94548 24927 32394020
Subclavian vein thrombosis 15.20 12.98 16 94563 910 32418037
Adult T-cell lymphoma/leukaemia 15.17 12.98 10 94569 293 32418654
Meningitis tuberculous 15.08 12.98 14 94565 683 32418264
Superior vena cava syndrome 15.06 12.98 13 94566 576 32418371
Skin laceration 15.05 12.98 8 94571 11958 32406989
Neck pain 15.04 12.98 27 94552 22760 32396187
Obstructive airways disorder 15.04 12.98 8 94571 11953 32406994
Cavernous sinus thrombosis 15.03 12.98 8 94571 156 32418791
Follicular lymphoma 15.02 12.98 6 94573 58 32418889
Ganglioneuroma 15 12.98 4 94575 8 32418939
Respiratory depression 14.97 12.98 10 94569 13201 32405746
Mononeuropathy multiplex 14.94 12.98 8 94571 158 32418789
No adverse event 14.89 12.98 22 94557 20031 32398916
Wound 14.88 12.98 10 94569 13157 32405790
Gastrointestinal injury 14.78 12.98 11 94568 393 32418554
Non-alcoholic steatohepatitis 14.75 12.98 15 94564 819 32418128
Viral load increased 14.75 12.98 30 94549 3120 32415827
Congenital hepatobiliary anomaly 14.71 12.98 5 94574 29 32418918
Ill-defined disorder 14.66 12.98 71 94508 11818 32407129
Aplastic anaemia 14.63 12.98 51 94528 7322 32411625
Medication error 14.61 12.98 27 94552 22508 32396439
Philadelphia chromosome positive 14.56 12.98 10 94569 314 32418633
Salivary gland atrophy 14.53 12.98 3 94576 0 32418947
Alveolar rhabdomyosarcoma 14.53 12.98 3 94576 0 32418947
Anal candidiasis 14.53 12.98 3 94576 0 32418947
Rash maculo-papular 14.52 12.98 38 94541 27984 32390963
Paternal exposure timing unspecified 14.43 12.98 5 94574 31 32418916
Klebsiella bacteraemia 14.40 12.98 18 94561 1234 32417713
Acute respiratory distress syndrome 14.39 12.98 124 94455 25129 32393818
Human metapneumovirus test positive 14.34 12.98 6 94573 66 32418881
Gliosis 14.34 12.98 8 94571 172 32418775
Mantle cell lymphoma stage IV 14.26 12.98 6 94573 67 32418880
Retinal pigment epitheliopathy 14.24 12.98 9 94570 245 32418702
Hypertensive crisis 14.22 12.98 4 94575 8813 32410134
Neurological decompensation 14.21 12.98 27 94552 2671 32416276
Muscle twitching 14.14 12.98 4 94575 8780 32410167
Cytomegalovirus enterocolitis 14.13 12.98 15 94564 862 32418085
Paresis 14.12 12.98 23 94556 2014 32416933
Lung adenocarcinoma stage I 14.12 12.98 4 94575 11 32418936
Lewis-Sumner syndrome 14.04 12.98 5 94574 34 32418913
Rectal adenoma 14.04 12.98 5 94574 34 32418913
Coronary artery occlusion 13.98 12.98 8 94571 11477 32407470
Frequent bowel movements 13.98 12.98 5 94574 9447 32409500
Candida pneumonia 13.97 12.98 10 94569 336 32418611
Hypouricaemia 13.95 12.98 9 94570 254 32418693
Miosis 13.94 12.98 4 94575 8700 32410247
Retinoblastoma 13.92 12.98 5 94574 35 32418912
Eye excision 13.92 12.98 5 94574 35 32418912
Optic nerve disorder 13.90 12.98 13 94566 640 32418307
Tooth disorder 13.87 12.98 6 94573 10101 32408846
Peripheral T-cell lymphoma unspecified refractory 13.86 12.98 4 94575 12 32418935
Deafness neurosensory 13.86 12.98 27 94552 2721 32416226
Vocal cord paresis 13.81 12.98 7 94572 123 32418824
Disorder of orbit 13.80 12.98 6 94573 73 32418874
Cryptococcosis 13.77 12.98 23 94556 2057 32416890
Angiodysplasia 13.71 12.98 12 94567 542 32418405
Guillain-Barre syndrome 13.70 12.98 41 94538 5433 32413514
Blood urea increased 13.69 12.98 48 94531 32225 32386722
Neuroborreliosis 13.68 12.98 5 94574 37 32418910
Retroperitoneal lymphadenopathy 13.67 12.98 14 94565 771 32418176
Accidental overdose 13.61 12.98 22 94557 19317 32399630
Abnormal dreams 13.60 12.98 4 94575 8560 32410387
Joint stiffness 13.54 12.98 6 94573 9959 32408988
Panic attack 13.52 12.98 5 94574 9256 32409691
Iris atrophy 13.52 12.98 6 94573 77 32418870
Pulmonary oedema 13.52 12.98 79 94500 46188 32372759
Mastitis 13.51 12.98 8 94571 193 32418754
Kidney transplant rejection 13.51 12.98 3 94576 7752 32411195
Bladder spasm 13.51 12.98 15 94564 907 32418040
Arteriosclerosis coronary artery 13.46 12.98 9 94570 11872 32407075
Acinetobacter sepsis 13.45 12.98 5 94574 39 32418908
Abdominal mass 13.45 12.98 18 94561 1321 32417626
Haematuria 13.38 12.98 84 94495 48277 32370670
Mucosal toxicity 13.37 12.98 8 94571 197 32418750
Enteritis 13.36 12.98 49 94530 7212 32411735
Meningoradiculitis 13.35 12.98 5 94574 40 32418907
Pneumothorax spontaneous 13.35 12.98 11 94568 457 32418490
Gastrointestinal mucosal disorder 13.32 12.98 10 94569 362 32418585
Hepatitis fulminant 13.32 12.98 34 94545 4109 32414838
Deafness 13.30 12.98 65 94514 10860 32408087
Splenic candidiasis 13.25 12.98 6 94573 81 32418866
Chronic lymphocytic leukaemia transformation 13.23 12.98 8 94571 201 32418746
White blood cell count abnormal 13.22 12.98 28 94551 2996 32415951
Meningitis bacterial 13.22 12.98 17 94562 1200 32417747
Blood urine present 13.20 12.98 7 94572 10478 32408469
Postural tremor 13.20 12.98 10 94569 367 32418580
Human polyomavirus infection 13.18 12.98 13 94566 684 32418263
Acute myocardial infarction 13.18 12.98 100 94479 55049 32363898
Renal disorder 13.17 12.98 34 94545 25149 32393798
Feeling hot 13.06 12.98 18 94561 16868 32402079
Cancer fatigue 13.03 12.98 5 94574 43 32418904
Hepatosplenic T-cell lymphoma 13.02 12.98 11 94568 473 32418474
Neoplasm 13.01 12.98 35 94544 4366 32414581
Areflexia 13.00 12.98 27 94552 2849 32416098
Necrotic lymphadenopathy 12.98 12.98 4 94575 16 32418931

Pharmacologic Action:

SourceCodeDescription
ATC L01CA02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Vinca alkaloids and analogues
FDA CS M0022674 Vinca Alkaloids
MeSH PA D050256 Antimitotic Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000972 Antineoplastic Agents, Phytogenic
MeSH PA D050257 Tubulin Modulators
FDA EPC N0000175612 Vinca Alkaloid
CHEBI has role CHEBI:23888 drugs
CHEBI has role CHEBI:35610 cytostatic
CHEBI has role CHEBI:60832 tubulin modulators
CHEBI has role CHEBI:61951 microtubule destabilising role
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:176497 anti-aging drugs

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Acute lymphoid leukemia indication 91857003 DOID:9952
Diffuse non-Hodgkin's lymphoma, large cell indication 109969005
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Rhabdomyosarcoma indication 302847003 DOID:3247
Nephroblastoma indication 302849000 DOID:2154
Follicular non-Hodgkin's lymphoma indication 308121000
Neuroblastoma indication 432328008 DOID:769
Astrocytoma, anaplastic off-label use 55353007 DOID:3078
Ewing's sarcoma off-label use 76909002 DOID:3369
Chronic lymphoid leukemia, disease off-label use 92814006
Multiple myeloma off-label use 109989006 DOID:9538
Mycosis fungoides off-label use 118618005
Small cell carcinoma of lung off-label use 254632001 DOID:5409
Glioblastoma multiforme of brain off-label use 276828006 DOID:3073
Primary cutaneous T-cell lymphoma off-label use 400122007
Ovarian Germ Cell Tumor Carcinoma off-label use
Mycosis contraindication 3218000 DOID:1564
Hyperbilirubinemia contraindication 14783006 DOID:2741
Obstruction of bile duct contraindication 30144000
Viral disease contraindication 34014006 DOID:934
Hyperuricemia contraindication 35885006 DOID:1920
Charcot-Marie-Tooth disease contraindication 50548001
Hepatic failure contraindication 59927004
Leukopenia contraindication 84828003 DOID:615
Bacterial infectious disease contraindication 87628006
Peripheral motor neuropathy contraindication 95663000 DOID:683
Neuromyopathy contraindication 255522009 DOID:440
Uric acid renal calculus contraindication 274401005
Pregnancy, function contraindication 289908002
Peripheral nerve disease contraindication 302226006
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Protozoal Infection contraindication
Polyneuropathies contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.02 acidic
pKa2 13.81 acidic
pKa3 7.2 Basic
pKa4 6.58 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Tubulin beta Tumour-associated antigen INHIBITOR SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Multidrug resistance protein 1 Transporter WOMBAT-PK
Canalicular multispecific organic anion transporter 1 Transporter WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter WOMBAT-PK
Multidrug resistance-associated protein 7 Transporter WOMBAT-PK
Tubulin Structural IC50 5.74 CHEMBL

External reference:

IDSource
4019971 VUID
N0000148056 NUI
D02197 KEGG_DRUG
2068-78-2 SECONDARY_CAS_RN
4017542 VANDF
4019971 VANDF
C0042679 UMLSCUI
CHEBI:28445 CHEBI
R1Q PDB_CHEM_ID
CHEMBL90555 ChEMBL_ID
CHEMBL501867 ChEMBL_ID
D014750 MESH_DESCRIPTOR_UI
DB00541 DRUGBANK_ID
6785 IUPHAR_LIGAND_ID
1440 INN_ID
5J49Q6B70F UNII
5978 PUBCHEM_CID
11202 RXNORM
5133 MMSL
5675 MMSL
7308 MMSL
879 MMSL
d00401 MMSL
002656 NDDF
004894 NDDF
23079006 SNOMEDCT_US
387126006 SNOMEDCT_US
387427007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Vincasar PFS HUMAN PRESCRIPTION DRUG LABEL 1 0703-4402 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 20 sections
Vincasar PFS HUMAN PRESCRIPTION DRUG LABEL 1 0703-4412 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 20 sections
VinCRIStine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 61703-309 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 22 sections
VinCRIStine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 61703-309 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 22 sections