Stem definition | Drug id | CAS RN |
---|---|---|
vinca alkaloids | 2825 | 57-22-7 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 10 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 15 % | Benet LZ, Broccatelli F, Oprea TI |
Vd (Volume of distribution) | 2.40 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 2 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.40 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 23 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
July 10, 1963 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 3992.66 | 13.52 | 2203 | 70549 | 102733 | 53173581 |
Neutropenia | 1542.75 | 13.52 | 1456 | 71296 | 157729 | 53118585 |
Febrile bone marrow aplasia | 865.62 | 13.52 | 337 | 72415 | 6852 | 53269462 |
Haematotoxicity | 646.80 | 13.52 | 281 | 72471 | 7616 | 53268698 |
Pancytopenia | 637.86 | 13.52 | 700 | 72052 | 90228 | 53186086 |
Bone marrow failure | 624.35 | 13.52 | 431 | 72321 | 29684 | 53246630 |
Product use in unapproved indication | 621.29 | 13.52 | 765 | 71987 | 111524 | 53164790 |
Mucosal inflammation | 597.48 | 13.52 | 483 | 72269 | 42301 | 53234013 |
Diffuse large B-cell lymphoma recurrent | 558.76 | 13.52 | 169 | 72583 | 1527 | 53274787 |
Myelodysplastic syndrome | 515.59 | 13.52 | 307 | 72445 | 16353 | 53259961 |
Posterior reversible encephalopathy syndrome | 505.88 | 13.52 | 300 | 72452 | 15860 | 53260454 |
Second primary malignancy | 501.29 | 13.52 | 228 | 72524 | 6904 | 53269410 |
Acute myeloid leukaemia | 492.93 | 13.52 | 300 | 72452 | 16632 | 53259682 |
Thrombocytopenia | 488.30 | 13.52 | 760 | 71992 | 137967 | 53138347 |
Sepsis | 469.81 | 13.52 | 769 | 71983 | 145660 | 53130654 |
Venoocclusive liver disease | 448.64 | 13.52 | 185 | 72567 | 4387 | 53271927 |
Tumour lysis syndrome | 431.37 | 13.52 | 212 | 72540 | 7662 | 53268652 |
Rheumatoid arthritis | 407.47 | 13.52 | 4 | 72748 | 314527 | 52961787 |
Septic shock | 406.72 | 13.52 | 462 | 72290 | 61767 | 53214547 |
Diffuse large B-cell lymphoma | 361.80 | 13.52 | 178 | 72574 | 6447 | 53269867 |
Neurotoxicity | 347.31 | 13.52 | 232 | 72520 | 15117 | 53261197 |
Acute lymphocytic leukaemia recurrent | 341.68 | 13.52 | 125 | 72627 | 2123 | 53274191 |
Pain | 336.96 | 13.52 | 193 | 72559 | 588205 | 52688109 |
Hypofibrinogenaemia | 323.33 | 13.52 | 102 | 72650 | 1073 | 53275241 |
Pyrexia | 306.90 | 13.52 | 1222 | 71530 | 401971 | 52874343 |
Ovarian failure | 292.64 | 13.52 | 94 | 72658 | 1053 | 53275261 |
Hepatitis B | 278.47 | 13.52 | 126 | 72626 | 3766 | 53272548 |
Progressive multifocal leukoencephalopathy | 278.43 | 13.52 | 185 | 72567 | 11944 | 53264370 |
Neutropenic sepsis | 276.35 | 13.52 | 198 | 72554 | 14451 | 53261863 |
Myelosuppression | 276.12 | 13.52 | 188 | 72564 | 12640 | 53263674 |
Joint swelling | 250.80 | 13.52 | 18 | 72734 | 234620 | 53041694 |
Disease progression | 248.51 | 13.52 | 475 | 72277 | 101445 | 53174869 |
Multiple organ dysfunction syndrome | 243.13 | 13.52 | 338 | 72414 | 55339 | 53220975 |
Acute lymphocytic leukaemia | 241.27 | 13.52 | 104 | 72648 | 2761 | 53273553 |
Diffuse large B-cell lymphoma refractory | 233.42 | 13.52 | 78 | 72674 | 998 | 53275316 |
Disease recurrence | 227.81 | 13.52 | 205 | 72547 | 20741 | 53255573 |
Cardiotoxicity | 227.05 | 13.52 | 135 | 72617 | 7164 | 53269150 |
Fall | 224.88 | 13.52 | 104 | 72648 | 358336 | 52917978 |
Staphylococcal bacteraemia | 223.08 | 13.52 | 119 | 72633 | 5114 | 53271200 |
Neutrophil count decreased | 215.76 | 13.52 | 299 | 72453 | 48799 | 53227515 |
Abdominal discomfort | 207.44 | 13.52 | 28 | 72724 | 221034 | 53055280 |
Product dose omission issue | 206.76 | 13.52 | 14 | 72738 | 191606 | 53084708 |
Leukopenia | 206.28 | 13.52 | 364 | 72388 | 73099 | 53203215 |
Off label use | 205.17 | 13.52 | 1219 | 71533 | 470993 | 52805321 |
Pruritus | 204.14 | 13.52 | 73 | 72679 | 293759 | 52982555 |
Neuropathy peripheral | 204.09 | 13.52 | 441 | 72311 | 102746 | 53173568 |
Neutropenic colitis | 201.67 | 13.52 | 89 | 72663 | 2504 | 53273810 |
Haemophagocytic lymphohistiocytosis | 199.23 | 13.52 | 135 | 72617 | 9002 | 53267312 |
Maternal exposure before pregnancy | 197.58 | 13.52 | 113 | 72639 | 5573 | 53270741 |
Nasopharyngitis | 196.42 | 13.52 | 18 | 72734 | 192277 | 53084037 |
Aplasia | 191.96 | 13.52 | 100 | 72652 | 4092 | 53272222 |
Fatigue | 190.65 | 13.52 | 450 | 72302 | 730056 | 52546258 |
Post transplant lymphoproliferative disorder | 185.20 | 13.52 | 99 | 72653 | 4272 | 53272042 |
Neoplasm progression | 183.33 | 13.52 | 215 | 72537 | 29704 | 53246610 |
Platelet count decreased | 182.61 | 13.52 | 434 | 72318 | 107665 | 53168649 |
Pneumocystis jirovecii pneumonia | 181.47 | 13.52 | 162 | 72590 | 16216 | 53260098 |
Peripheral swelling | 179.97 | 13.52 | 32 | 72720 | 206076 | 53070238 |
Arthralgia | 177.92 | 13.52 | 203 | 72549 | 439580 | 52836734 |
Hepatitis B reactivation | 176.04 | 13.52 | 75 | 72677 | 1933 | 53274381 |
B-cell lymphoma recurrent | 172.21 | 13.52 | 50 | 72702 | 386 | 53275928 |
Drug resistance | 170.60 | 13.52 | 171 | 72581 | 19791 | 53256523 |
Epstein-Barr virus infection | 165.08 | 13.52 | 111 | 72641 | 7307 | 53269007 |
Hypertriglyceridaemia | 163.93 | 13.52 | 104 | 72648 | 6200 | 53270114 |
Ileus paralytic | 163.88 | 13.52 | 93 | 72659 | 4518 | 53271796 |
Rash | 158.66 | 13.52 | 227 | 72525 | 445964 | 52830350 |
Contraindicated product administered | 158.61 | 13.52 | 6 | 72746 | 135623 | 53140691 |
Headache | 156.92 | 13.52 | 310 | 72442 | 536511 | 52739803 |
Drug hypersensitivity | 154.14 | 13.52 | 85 | 72667 | 265157 | 53011157 |
Weight increased | 154.08 | 13.52 | 44 | 72708 | 204523 | 53071791 |
Arthropathy | 150.62 | 13.52 | 11 | 72741 | 141442 | 53134872 |
Dizziness | 150.27 | 13.52 | 172 | 72580 | 372087 | 52904227 |
Hyperbilirubinaemia | 150.21 | 13.52 | 123 | 72629 | 10946 | 53265368 |
Swelling | 145.98 | 13.52 | 40 | 72712 | 191065 | 53085249 |
Cardiomyopathy | 145.32 | 13.52 | 146 | 72606 | 16942 | 53259372 |
Cytopenia | 143.93 | 13.52 | 111 | 72641 | 9059 | 53267255 |
Neoplasm recurrence | 143.18 | 13.52 | 69 | 72683 | 2385 | 53273929 |
Leukoencephalopathy | 136.28 | 13.52 | 80 | 72672 | 4144 | 53272170 |
Anxiety | 132.91 | 13.52 | 51 | 72701 | 196653 | 53079661 |
Feeling abnormal | 132.06 | 13.52 | 15 | 72737 | 135286 | 53141028 |
Synovitis | 128.85 | 13.52 | 4 | 72748 | 107889 | 53168425 |
Malignant neoplasm progression | 128.14 | 13.52 | 294 | 72458 | 71247 | 53205067 |
Insomnia | 127.22 | 13.52 | 48 | 72704 | 187024 | 53089290 |
Mucormycosis | 124.73 | 13.52 | 64 | 72688 | 2536 | 53273778 |
Blood culture positive | 124.45 | 13.52 | 78 | 72674 | 4551 | 53271763 |
Pneumatosis intestinalis | 121.59 | 13.52 | 60 | 72692 | 2186 | 53274128 |
Injection site pain | 120.18 | 13.52 | 9 | 72743 | 113382 | 53162932 |
Bacteraemia | 119.82 | 13.52 | 126 | 72626 | 15423 | 53260891 |
Sinusitis | 118.43 | 13.52 | 41 | 72711 | 168523 | 53107791 |
Drug intolerance | 116.25 | 13.52 | 68 | 72684 | 205425 | 53070889 |
Musculoskeletal stiffness | 114.75 | 13.52 | 16 | 72736 | 123352 | 53152962 |
Anaemia | 114.36 | 13.52 | 706 | 72046 | 276012 | 53000302 |
Hypogammaglobulinaemia | 110.03 | 13.52 | 80 | 72672 | 5970 | 53270344 |
Disseminated intravascular coagulation | 109.79 | 13.52 | 135 | 72617 | 19584 | 53256730 |
White blood cell count decreased | 108.71 | 13.52 | 395 | 72357 | 124080 | 53152234 |
Blood lactate dehydrogenase increased | 108.40 | 13.52 | 141 | 72611 | 21640 | 53254674 |
Temporal lobe epilepsy | 107.48 | 13.52 | 34 | 72718 | 361 | 53275953 |
Asthma | 106.54 | 13.52 | 12 | 72740 | 108960 | 53167354 |
Therapy partial responder | 106.45 | 13.52 | 79 | 72673 | 6084 | 53270230 |
Psoriasis | 104.82 | 13.52 | 3 | 72749 | 87086 | 53189228 |
Lymphopenia | 104.76 | 13.52 | 122 | 72630 | 16721 | 53259593 |
Cerebral venous thrombosis | 104.71 | 13.52 | 55 | 72697 | 2289 | 53274025 |
Drug ineffective | 103.38 | 13.52 | 673 | 72079 | 816572 | 52459742 |
Polyneuropathy | 103.34 | 13.52 | 108 | 72644 | 13125 | 53263189 |
Dyspnoea | 103.11 | 13.52 | 431 | 72321 | 585801 | 52690513 |
Respiratory failure | 102.61 | 13.52 | 336 | 72416 | 100176 | 53176138 |
Central nervous system lymphoma | 102.44 | 13.52 | 47 | 72705 | 1451 | 53274863 |
Therapeutic product effect decreased | 102.32 | 13.52 | 23 | 72729 | 125632 | 53150682 |
Myelopathy | 102.25 | 13.52 | 57 | 72695 | 2674 | 53273640 |
Secondary immunodeficiency | 102.25 | 13.52 | 43 | 72709 | 1072 | 53275242 |
Malaise | 102.13 | 13.52 | 209 | 72543 | 357408 | 52918906 |
Systemic candida | 101.53 | 13.52 | 59 | 72693 | 2998 | 53273316 |
Pleural effusion | 101.33 | 13.52 | 308 | 72444 | 88271 | 53188043 |
Wound | 100.74 | 13.52 | 6 | 72746 | 91551 | 53184763 |
Lennox-Gastaut syndrome | 96.35 | 13.52 | 29 | 72723 | 257 | 53276057 |
Bone pain | 95.88 | 13.52 | 213 | 72539 | 50509 | 53225805 |
Blood pressure increased | 95.56 | 13.52 | 36 | 72716 | 140443 | 53135871 |
Stem cell transplant | 93.12 | 13.52 | 47 | 72705 | 1798 | 53274516 |
Fungaemia | 91.36 | 13.52 | 49 | 72703 | 2128 | 53274186 |
Pain in extremity | 89.75 | 13.52 | 157 | 72595 | 284893 | 52991421 |
Discomfort | 89.68 | 13.52 | 12 | 72740 | 95460 | 53180854 |
Ascites | 89.19 | 13.52 | 179 | 72573 | 39556 | 53236758 |
Smooth muscle cell neoplasm | 88.30 | 13.52 | 34 | 72718 | 669 | 53275645 |
Arthritis | 86.89 | 13.52 | 9 | 72743 | 87289 | 53189025 |
Hepatic failure | 86.05 | 13.52 | 166 | 72586 | 35640 | 53240674 |
Venoocclusive disease | 85.53 | 13.52 | 46 | 72706 | 2009 | 53274305 |
Epstein-Barr virus associated lymphoproliferative disorder | 85.15 | 13.52 | 43 | 72709 | 1647 | 53274667 |
Klebsiella infection | 85.03 | 13.52 | 77 | 72675 | 7849 | 53268465 |
Contusion | 84.84 | 13.52 | 23 | 72729 | 110709 | 53165605 |
Peripheral motor neuropathy | 84.63 | 13.52 | 42 | 72710 | 1549 | 53274765 |
Cerebral venous sinus thrombosis | 82.10 | 13.52 | 44 | 72708 | 1908 | 53274406 |
Ejection fraction decreased | 81.40 | 13.52 | 117 | 72635 | 19731 | 53256583 |
Muscle spasms | 79.95 | 13.52 | 42 | 72710 | 134753 | 53141561 |
Enterococcal infection | 79.91 | 13.52 | 73 | 72679 | 7525 | 53268789 |
Leukaemia recurrent | 79.87 | 13.52 | 39 | 72713 | 1388 | 53274926 |
Lymphadenopathy | 79.79 | 13.52 | 162 | 72590 | 36093 | 53240221 |
Overdose | 79.54 | 13.52 | 24 | 72728 | 107712 | 53168602 |
Hepatocellular injury | 79.51 | 13.52 | 145 | 72607 | 29841 | 53246473 |
B-cell lymphoma | 77.48 | 13.52 | 52 | 72700 | 3411 | 53272903 |
Clostridium difficile colitis | 77.40 | 13.52 | 114 | 72638 | 19651 | 53256663 |
Injection site erythema | 76.79 | 13.52 | 8 | 72744 | 77241 | 53199073 |
Agranulocytosis | 76.27 | 13.52 | 125 | 72627 | 23624 | 53252690 |
Nephroblastoma | 75.79 | 13.52 | 20 | 72732 | 103 | 53276211 |
Depression | 74.33 | 13.52 | 84 | 72668 | 182968 | 53093346 |
Superior sagittal sinus thrombosis | 73.79 | 13.52 | 32 | 72720 | 862 | 53275452 |
Alopecia | 73.09 | 13.52 | 130 | 72622 | 234453 | 53041861 |
Aspergillus infection | 73.00 | 13.52 | 69 | 72683 | 7427 | 53268887 |
Congestive cardiomyopathy | 72.55 | 13.52 | 63 | 72689 | 6075 | 53270239 |
Escherichia bacteraemia | 72.40 | 13.52 | 49 | 72703 | 3259 | 53273055 |
Bronchopulmonary aspergillosis | 71.77 | 13.52 | 73 | 72679 | 8592 | 53267722 |
Colitis | 71.34 | 13.52 | 168 | 72584 | 41384 | 53234930 |
Inappropriate schedule of product administration | 71.31 | 13.52 | 9 | 72743 | 74869 | 53201445 |
Bronchitis | 69.16 | 13.52 | 33 | 72719 | 111866 | 53164448 |
Cystitis haemorrhagic | 69.11 | 13.52 | 51 | 72701 | 3893 | 53272421 |
Migraine | 69.01 | 13.52 | 13 | 72739 | 80404 | 53195910 |
Urticaria | 68.63 | 13.52 | 51 | 72701 | 135834 | 53140480 |
Hypersensitivity | 68.12 | 13.52 | 114 | 72638 | 210551 | 53065763 |
Enterococcal bacteraemia | 67.26 | 13.52 | 34 | 72718 | 1305 | 53275009 |
Hospitalisation | 66.51 | 13.52 | 9 | 72743 | 71003 | 53205311 |
Peripheral sensory neuropathy | 66.21 | 13.52 | 64 | 72688 | 7084 | 53269230 |
Gene mutation | 65.68 | 13.52 | 33 | 72719 | 1250 | 53275064 |
Abdominal pain upper | 65.68 | 13.52 | 78 | 72674 | 166213 | 53110101 |
Cervix disorder | 65.25 | 13.52 | 25 | 72727 | 485 | 53275829 |
Pseudomonas test positive | 64.37 | 13.52 | 28 | 72724 | 760 | 53275554 |
B precursor type acute leukaemia | 63.77 | 13.52 | 20 | 72732 | 206 | 53276108 |
Condition aggravated | 62.17 | 13.52 | 203 | 72549 | 296931 | 52979383 |
Palpitations | 62.01 | 13.52 | 31 | 72721 | 102317 | 53173997 |
Candida infection | 61.74 | 13.52 | 118 | 72634 | 25155 | 53251159 |
Refractory anaemia with an excess of blasts | 61.32 | 13.52 | 23 | 72729 | 420 | 53275894 |
Encephalopathy | 61.21 | 13.52 | 147 | 72605 | 36661 | 53239653 |
Chest pain | 60.49 | 13.52 | 104 | 72648 | 190081 | 53086233 |
Retinoblastoma | 60.37 | 13.52 | 17 | 72735 | 116 | 53276198 |
Pneumocystis jirovecii infection | 60.19 | 13.52 | 32 | 72720 | 1365 | 53274949 |
JC virus infection | 59.81 | 13.52 | 35 | 72717 | 1802 | 53274512 |
Respiratory distress | 59.41 | 13.52 | 138 | 72614 | 33689 | 53242625 |
Quadriplegia | 59.09 | 13.52 | 35 | 72717 | 1843 | 53274471 |
Myeloid leukaemia | 59.01 | 13.52 | 21 | 72731 | 328 | 53275986 |
Rhinovirus infection | 58.94 | 13.52 | 46 | 72706 | 3819 | 53272495 |
Vocal cord paralysis | 58.90 | 13.52 | 35 | 72717 | 1854 | 53274460 |
Cytomegalovirus infection | 57.62 | 13.52 | 99 | 72653 | 19440 | 53256874 |
Pneumonia fungal | 57.49 | 13.52 | 49 | 72703 | 4607 | 53271707 |
Lymphoma transformation | 57.37 | 13.52 | 17 | 72735 | 142 | 53276172 |
Ileus | 56.75 | 13.52 | 85 | 72667 | 14870 | 53261444 |
Herpes simplex | 56.66 | 13.52 | 61 | 72691 | 7668 | 53268646 |
Hepatomegaly | 56.40 | 13.52 | 75 | 72677 | 11756 | 53264558 |
Astrocytoma, low grade | 56.33 | 13.52 | 14 | 72738 | 54 | 53276260 |
Acute myelomonocytic leukaemia | 56.32 | 13.52 | 18 | 72734 | 198 | 53276116 |
Glioma | 56.22 | 13.52 | 20 | 72732 | 312 | 53276002 |
Nausea | 55.77 | 13.52 | 713 | 72039 | 755378 | 52520936 |
Lymphoma | 55.52 | 13.52 | 70 | 72682 | 10412 | 53265902 |
Infection | 55.22 | 13.52 | 413 | 72339 | 171792 | 53104522 |
Injection site reaction | 54.37 | 13.52 | 4 | 72748 | 51162 | 53225152 |
Epstein-Barr virus associated lymphoma | 53.90 | 13.52 | 21 | 72731 | 427 | 53275887 |
Fusarium infection | 53.86 | 13.52 | 23 | 72729 | 596 | 53275718 |
Enterovirus test positive | 53.85 | 13.52 | 16 | 72736 | 135 | 53276179 |
Antithrombin III decreased | 53.73 | 13.52 | 19 | 72733 | 291 | 53276023 |
Bacterial sepsis | 53.69 | 13.52 | 44 | 72708 | 3918 | 53272396 |
Hepatic enzyme increased | 53.32 | 13.52 | 56 | 72696 | 126139 | 53150175 |
Osteoarthritis | 53.30 | 13.52 | 15 | 72737 | 70471 | 53205843 |
Loss of personal independence in daily activities | 52.53 | 13.52 | 15 | 72737 | 69800 | 53206514 |
Venous thrombosis | 52.39 | 13.52 | 48 | 72704 | 4966 | 53271348 |
Blood fibrinogen decreased | 52.33 | 13.52 | 24 | 72728 | 740 | 53275574 |
Intentional product misuse | 52.09 | 13.52 | 4 | 72748 | 49388 | 53226926 |
Pericarditis | 51.98 | 13.52 | 12 | 72740 | 64394 | 53211920 |
Human bocavirus infection | 51.85 | 13.52 | 19 | 72733 | 324 | 53275990 |
Osteonecrosis | 51.79 | 13.52 | 113 | 72639 | 26462 | 53249852 |
Pulmonary haemorrhage | 51.32 | 13.52 | 55 | 72697 | 6878 | 53269436 |
Hyperglycaemia | 51.17 | 13.52 | 145 | 72607 | 39939 | 53236375 |
Device related infection | 50.35 | 13.52 | 102 | 72650 | 22684 | 53253630 |
Ototoxicity | 50.12 | 13.52 | 27 | 72725 | 1183 | 53275131 |
Pyomyositis | 49.76 | 13.52 | 19 | 72733 | 365 | 53275949 |
Heart rate abnormal | 49.19 | 13.52 | 42 | 72710 | 3958 | 53272356 |
Hepatotoxicity | 48.15 | 13.52 | 113 | 72639 | 27767 | 53248547 |
Influenza like illness | 47.82 | 13.52 | 12 | 72740 | 60847 | 53215467 |
Cytokine release syndrome | 47.43 | 13.52 | 57 | 72695 | 8072 | 53268242 |
Lower respiratory tract infection | 47.42 | 13.52 | 33 | 72719 | 90948 | 53185366 |
Stomatitis | 47.25 | 13.52 | 261 | 72491 | 97897 | 53178417 |
Human herpesvirus 6 infection | 47.25 | 13.52 | 34 | 72718 | 2496 | 53273818 |
Left ventricular dysfunction | 47.19 | 13.52 | 67 | 72685 | 11170 | 53265144 |
Human rhinovirus test positive | 46.94 | 13.52 | 15 | 72737 | 165 | 53276149 |
Mantle cell lymphoma recurrent | 46.93 | 13.52 | 14 | 72738 | 120 | 53276194 |
Neck pain | 46.84 | 13.52 | 12 | 72740 | 60004 | 53216310 |
Perineal necrosis | 46.82 | 13.52 | 14 | 72738 | 121 | 53276193 |
Lung infiltration | 46.67 | 13.52 | 77 | 72675 | 14630 | 53261684 |
Hyperpyrexia | 46.64 | 13.52 | 38 | 72714 | 3356 | 53272958 |
Cutaneous calcification | 46.26 | 13.52 | 13 | 72739 | 88 | 53276226 |
Drug abuse | 45.87 | 13.52 | 16 | 72736 | 65510 | 53210804 |
Staphylococcal sepsis | 45.79 | 13.52 | 55 | 72697 | 7785 | 53268529 |
Leukaemia cutis | 45.76 | 13.52 | 13 | 72739 | 92 | 53276222 |
Diarrhoea | 45.63 | 13.52 | 591 | 72161 | 624955 | 52651359 |
Suicidal ideation | 45.53 | 13.52 | 13 | 72739 | 60498 | 53215816 |
Perineal infection | 45.37 | 13.52 | 14 | 72738 | 136 | 53276178 |
Toxic neuropathy | 45.35 | 13.52 | 18 | 72734 | 385 | 53275929 |
Cardiac failure | 45.23 | 13.52 | 234 | 72518 | 85610 | 53190704 |
Premature menopause | 44.97 | 13.52 | 22 | 72730 | 786 | 53275528 |
Mobility decreased | 44.86 | 13.52 | 24 | 72728 | 76247 | 53200067 |
Philadelphia chromosome positive | 44.70 | 13.52 | 17 | 72735 | 323 | 53275991 |
Enterobacter infection | 44.45 | 13.52 | 30 | 72722 | 1986 | 53274328 |
Hot flush | 44.10 | 13.52 | 6 | 72746 | 47154 | 53229160 |
Choriocarcinoma | 43.93 | 13.52 | 13 | 72739 | 108 | 53276206 |
T-cell lymphoma | 43.46 | 13.52 | 21 | 72731 | 730 | 53275584 |
Injection site swelling | 43.45 | 13.52 | 4 | 72748 | 42624 | 53233690 |
Histiocytic sarcoma | 43.25 | 13.52 | 12 | 72740 | 77 | 53276237 |
Blister | 43.16 | 13.52 | 27 | 72725 | 78726 | 53197588 |
Inappropriate antidiuretic hormone secretion | 43.10 | 13.52 | 75 | 72677 | 14876 | 53261438 |
Salivary gland cancer | 43.09 | 13.52 | 14 | 72738 | 163 | 53276151 |
Brain oedema | 43.04 | 13.52 | 71 | 72681 | 13487 | 53262827 |
B-cell lymphoma refractory | 42.60 | 13.52 | 12 | 72740 | 82 | 53276232 |
Irritable bowel syndrome | 42.14 | 13.52 | 5 | 72747 | 43627 | 53232687 |
Injury | 42.14 | 13.52 | 9 | 72743 | 50962 | 53225352 |
Injection site pruritus | 42.13 | 13.52 | 4 | 72748 | 41585 | 53234729 |
Osteomyelitis bacterial | 42.12 | 13.52 | 14 | 72738 | 176 | 53276138 |
Bone marrow disorder | 41.86 | 13.52 | 29 | 72723 | 2004 | 53274310 |
Adverse drug reaction | 41.32 | 13.52 | 11 | 72741 | 53614 | 53222700 |
Back pain | 41.11 | 13.52 | 172 | 72580 | 234075 | 53042239 |
Suicide attempt | 41.07 | 13.52 | 14 | 72738 | 58154 | 53218160 |
Intussusception | 40.96 | 13.52 | 18 | 72734 | 501 | 53275813 |
Coagulopathy | 40.96 | 13.52 | 86 | 72666 | 19612 | 53256702 |
Hepatitis E | 40.93 | 13.52 | 24 | 72728 | 1240 | 53275074 |
Acute hepatitis B | 40.85 | 13.52 | 16 | 72736 | 330 | 53275984 |
Mucosal toxicity | 40.72 | 13.52 | 16 | 72736 | 333 | 53275981 |
Incorrect dose administered | 40.23 | 13.52 | 10 | 72742 | 51035 | 53225279 |
Combined immunodeficiency | 40.00 | 13.52 | 12 | 72740 | 105 | 53276209 |
Cerebrovascular accident | 39.75 | 13.52 | 51 | 72701 | 105123 | 53171191 |
Growth hormone deficiency | 39.73 | 13.52 | 13 | 72739 | 155 | 53276159 |
Desmoplastic small round cell tumour | 39.61 | 13.52 | 14 | 72738 | 214 | 53276100 |
Humoral immune defect | 39.46 | 13.52 | 11 | 72741 | 72 | 53276242 |
Bacterial infection | 39.30 | 13.52 | 79 | 72673 | 17468 | 53258846 |
Dry mouth | 39.25 | 13.52 | 16 | 72736 | 59534 | 53216780 |
Transverse sinus thrombosis | 39.18 | 13.52 | 19 | 72733 | 666 | 53275648 |
Herpes zoster meningoencephalitis | 39.15 | 13.52 | 15 | 72737 | 291 | 53276023 |
Gastrosplenic fistula | 39.00 | 13.52 | 10 | 72742 | 45 | 53276269 |
Depressed mood | 38.96 | 13.52 | 3 | 72749 | 36961 | 53239353 |
Myocardial infarction | 38.78 | 13.52 | 47 | 72705 | 99307 | 53177007 |
Hypoalbuminaemia | 38.45 | 13.52 | 60 | 72692 | 10876 | 53265438 |
5q minus syndrome | 38.35 | 13.52 | 14 | 72738 | 236 | 53276078 |
Medulloblastoma recurrent | 38.22 | 13.52 | 11 | 72741 | 82 | 53276232 |
Lymphoproliferative disorder | 38.18 | 13.52 | 32 | 72720 | 2940 | 53273374 |
Impaired healing | 38.06 | 13.52 | 20 | 72732 | 64185 | 53212129 |
Lymphadenitis | 37.89 | 13.52 | 31 | 72721 | 2754 | 53273560 |
Blood glucose increased | 37.81 | 13.52 | 30 | 72722 | 77331 | 53198983 |
Cholestasis | 37.80 | 13.52 | 105 | 72647 | 28590 | 53247724 |
Plasmablastic lymphoma | 37.77 | 13.52 | 14 | 72738 | 247 | 53276067 |
Cytomegalovirus colitis | 37.51 | 13.52 | 27 | 72725 | 1983 | 53274331 |
Myalgia | 37.17 | 13.52 | 79 | 72673 | 133412 | 53142902 |
Blood pressure fluctuation | 37.04 | 13.52 | 3 | 72749 | 35467 | 53240847 |
Sleep disorder | 36.92 | 13.52 | 17 | 72735 | 58853 | 53217461 |
Gastroenteritis norovirus | 36.81 | 13.52 | 25 | 72727 | 1672 | 53274642 |
BK virus infection | 36.72 | 13.52 | 32 | 72720 | 3100 | 53273214 |
Cough | 36.71 | 13.52 | 203 | 72549 | 256690 | 53019624 |
Hyperhidrosis | 36.51 | 13.52 | 47 | 72705 | 96746 | 53179568 |
Memory impairment | 36.48 | 13.52 | 37 | 72715 | 84720 | 53191594 |
Urinary tract infection | 36.26 | 13.52 | 186 | 72566 | 239717 | 53036597 |
Seizure | 36.20 | 13.52 | 301 | 72451 | 129208 | 53147106 |
Acute promyelocytic leukaemia | 36.09 | 13.52 | 20 | 72732 | 927 | 53275387 |
Platelet count abnormal | 36.08 | 13.52 | 31 | 72721 | 2947 | 53273367 |
Chest discomfort | 35.99 | 13.52 | 50 | 72702 | 99645 | 53176669 |
Hemiparesis | 35.95 | 13.52 | 86 | 72666 | 21389 | 53254925 |
Therapeutic response delayed | 35.89 | 13.52 | 17 | 72735 | 565 | 53275749 |
Gastrooesophageal reflux disease | 35.68 | 13.52 | 36 | 72716 | 82627 | 53193687 |
Unmasking of previously unidentified disease | 35.62 | 13.52 | 19 | 72733 | 816 | 53275498 |
Areflexia | 35.56 | 13.52 | 31 | 72721 | 3005 | 53273309 |
Paraparesis | 35.22 | 13.52 | 27 | 72725 | 2183 | 53274131 |
Pneumonia | 35.06 | 13.52 | 763 | 71989 | 406406 | 52869908 |
Leukoerythroblastosis | 34.98 | 13.52 | 13 | 72739 | 231 | 53276083 |
Babesiosis | 34.98 | 13.52 | 13 | 72739 | 231 | 53276083 |
Recurrent cancer | 34.96 | 13.52 | 25 | 72727 | 1817 | 53274497 |
Burning sensation | 34.87 | 13.52 | 11 | 72741 | 48002 | 53228312 |
Glioblastoma multiforme | 34.76 | 13.52 | 19 | 72733 | 857 | 53275457 |
Haemorrhage intracranial | 34.67 | 13.52 | 64 | 72688 | 13288 | 53263026 |
Listeria sepsis | 34.48 | 13.52 | 17 | 72735 | 618 | 53275696 |
Confusional state | 34.44 | 13.52 | 142 | 72610 | 194079 | 53082235 |
Acute respiratory distress syndrome | 34.39 | 13.52 | 89 | 72663 | 23243 | 53253071 |
Rhinocerebral mucormycosis | 34.22 | 13.52 | 12 | 72740 | 179 | 53276135 |
Erythropoiesis abnormal | 33.84 | 13.52 | 13 | 72739 | 254 | 53276060 |
Leukaemic lymphoma | 33.80 | 13.52 | 10 | 72742 | 83 | 53276231 |
Clostridium test positive | 33.79 | 13.52 | 27 | 72725 | 2319 | 53273995 |
Hepatic infarction | 33.78 | 13.52 | 17 | 72735 | 646 | 53275668 |
Cytogenetic abnormality | 33.69 | 13.52 | 16 | 72736 | 535 | 53275779 |
Nail pigmentation | 33.57 | 13.52 | 12 | 72740 | 190 | 53276124 |
Malignant transformation | 33.55 | 13.52 | 14 | 72738 | 342 | 53275972 |
Somnolence | 33.39 | 13.52 | 117 | 72635 | 167617 | 53108697 |
Acute biphenotypic leukaemia | 33.39 | 13.52 | 9 | 72743 | 51 | 53276263 |
Staphylococcal infection | 33.32 | 13.52 | 122 | 72630 | 38426 | 53237888 |
Oesophageal candidiasis | 33.03 | 13.52 | 39 | 72713 | 5421 | 53270893 |
Cytomegalovirus chorioretinitis | 32.73 | 13.52 | 23 | 72729 | 1626 | 53274688 |
Femur fracture | 32.70 | 13.52 | 7 | 72745 | 39578 | 53236736 |
Cytomegalovirus viraemia | 32.46 | 13.52 | 37 | 72715 | 4954 | 53271360 |
Intracardiac thrombus | 32.39 | 13.52 | 27 | 72725 | 2462 | 53273852 |
Pseudomonas infection | 32.28 | 13.52 | 54 | 72698 | 10374 | 53265940 |
Cardiomyopathy acute | 32.15 | 13.52 | 12 | 72740 | 216 | 53276098 |
Gastrointestinal necrosis | 32.06 | 13.52 | 29 | 72723 | 2951 | 53273363 |
Infection reactivation | 32.00 | 13.52 | 19 | 72733 | 1005 | 53275309 |
White blood cell count abnormal | 31.97 | 13.52 | 38 | 72714 | 5320 | 53270994 |
Vision blurred | 31.84 | 13.52 | 42 | 72710 | 85562 | 53190752 |
Varicella zoster virus infection | 31.70 | 13.52 | 27 | 72725 | 2536 | 53273778 |
Blast cells present | 31.65 | 13.52 | 14 | 72738 | 396 | 53275918 |
Hallucination | 31.57 | 13.52 | 17 | 72735 | 53821 | 53222493 |
Tissue infiltration | 31.46 | 13.52 | 16 | 72736 | 622 | 53275692 |
Nephrolithiasis | 31.39 | 13.52 | 6 | 72746 | 36741 | 53239573 |
Encephalitis | 31.36 | 13.52 | 46 | 72706 | 7898 | 53268416 |
Pneumonia cytomegaloviral | 31.29 | 13.52 | 25 | 72727 | 2147 | 53274167 |
Necrotising gastritis | 31.28 | 13.52 | 9 | 72743 | 67 | 53276247 |
Pseudomonal sepsis | 31.22 | 13.52 | 25 | 72727 | 2154 | 53274160 |
Feeling hot | 31.11 | 13.52 | 9 | 72743 | 41535 | 53234779 |
Musculoskeletal pain | 31.05 | 13.52 | 34 | 72718 | 75166 | 53201148 |
Wheezing | 31.04 | 13.52 | 26 | 72726 | 65249 | 53211065 |
Antithrombin III | 31.01 | 13.52 | 11 | 72741 | 170 | 53276144 |
Nasal congestion | 30.99 | 13.52 | 17 | 72735 | 53270 | 53223044 |
Capillary leak syndrome | 30.88 | 13.52 | 24 | 72728 | 1980 | 53274334 |
Tumour necrosis | 30.86 | 13.52 | 17 | 72735 | 779 | 53275535 |
Gestational trophoblastic tumour | 30.35 | 13.52 | 8 | 72744 | 41 | 53276273 |
Oedema peripheral | 30.19 | 13.52 | 125 | 72627 | 170662 | 53105652 |
Carotid intima-media thickness increased | 30.18 | 13.52 | 9 | 72743 | 77 | 53276237 |
Potentiating drug interaction | 30.18 | 13.52 | 33 | 72719 | 4220 | 53272094 |
Surgery | 30.05 | 13.52 | 4 | 72748 | 31960 | 53244354 |
Philadelphia positive acute lymphocytic leukaemia | 30.03 | 13.52 | 8 | 72744 | 43 | 53276271 |
Unevaluable event | 29.96 | 13.52 | 15 | 72737 | 49483 | 53226831 |
Cryptococcosis | 29.94 | 13.52 | 18 | 72734 | 974 | 53275340 |
Hyperammonaemia | 29.87 | 13.52 | 36 | 72716 | 5113 | 53271201 |
Candida test positive | 29.74 | 13.52 | 18 | 72734 | 986 | 53275328 |
Haemolytic uraemic syndrome | 29.69 | 13.52 | 26 | 72726 | 2535 | 53273779 |
Premature baby | 29.66 | 13.52 | 76 | 72676 | 19725 | 53256589 |
Heart rate decreased | 29.58 | 13.52 | 7 | 72745 | 36940 | 53239374 |
Blood cholesterol increased | 29.26 | 13.52 | 18 | 72734 | 52971 | 53223343 |
Escherichia test positive | 29.25 | 13.52 | 24 | 72728 | 2141 | 53274173 |
Mucoepidermoid carcinoma | 29.15 | 13.52 | 8 | 72744 | 49 | 53276265 |
Refractory cytopenia with multilineage dysplasia | 29.10 | 13.52 | 10 | 72742 | 140 | 53276174 |
Flushing | 29.06 | 13.52 | 32 | 72720 | 70568 | 53205746 |
Dyspepsia | 28.94 | 13.52 | 38 | 72714 | 77562 | 53198752 |
Cerebellar stroke | 28.92 | 13.52 | 11 | 72741 | 209 | 53276105 |
Trichodysplasia spinulosa | 28.55 | 13.52 | 14 | 72738 | 503 | 53275811 |
Acquired gene mutation | 28.50 | 13.52 | 16 | 72736 | 761 | 53275553 |
Leukaemia | 28.49 | 13.52 | 30 | 72722 | 3676 | 53272638 |
Aplastic anaemia | 28.35 | 13.52 | 45 | 72707 | 8276 | 53268038 |
Loss of consciousness | 28.24 | 13.52 | 72 | 72680 | 114140 | 53162174 |
Chronic kidney disease | 28.02 | 13.52 | 12 | 72740 | 43358 | 53232956 |
Joint stiffness | 27.97 | 13.52 | 4 | 72748 | 30279 | 53246035 |
Subdural hygroma | 27.95 | 13.52 | 11 | 72741 | 230 | 53276084 |
Encephalitis viral | 27.91 | 13.52 | 21 | 72731 | 1651 | 53274663 |
Product quality issue | 27.76 | 13.52 | 8 | 72744 | 37015 | 53239299 |
Klebsiella bacteraemia | 27.55 | 13.52 | 19 | 72733 | 1303 | 53275011 |
Duodenal ulcer perforation | 27.52 | 13.52 | 7 | 72745 | 35176 | 53241138 |
Rhinorrhoea | 27.17 | 13.52 | 20 | 72732 | 53558 | 53222756 |
Subclavian vein thrombosis | 27.13 | 13.52 | 22 | 72730 | 1930 | 53274384 |
Therapy responder | 27.07 | 13.52 | 12 | 72740 | 341 | 53275973 |
Jugular vein thrombosis | 27.03 | 13.52 | 26 | 72726 | 2860 | 53273454 |
Ureaplasma infection | 27.02 | 13.52 | 14 | 72738 | 566 | 53275748 |
Angiocentric lymphoma | 26.98 | 13.52 | 14 | 72738 | 568 | 53275746 |
Mediastinum neoplasm | 26.87 | 13.52 | 8 | 72744 | 68 | 53276246 |
Therapy non-responder | 26.63 | 13.52 | 135 | 72617 | 48985 | 53227329 |
Sinusitis fungal | 26.59 | 13.52 | 19 | 72733 | 1379 | 53274935 |
Helicobacter infection | 26.56 | 13.52 | 10 | 72742 | 39059 | 53237255 |
Hepatosplenic candidiasis | 26.54 | 13.52 | 11 | 72741 | 264 | 53276050 |
Pulse waveform abnormal | 26.47 | 13.52 | 8 | 72744 | 72 | 53276242 |
Ankle brachial index decreased | 26.37 | 13.52 | 8 | 72744 | 73 | 53276241 |
Emotional distress | 26.12 | 13.52 | 6 | 72746 | 32311 | 53244003 |
Basal ganglion degeneration | 26.11 | 13.52 | 13 | 72739 | 483 | 53275831 |
Small intestinal obstruction | 25.88 | 13.52 | 66 | 72686 | 17081 | 53259233 |
Ocular vascular disorder | 25.87 | 13.52 | 12 | 72740 | 380 | 53275934 |
Splenomegaly | 25.81 | 13.52 | 49 | 72703 | 10390 | 53265924 |
Acute lymphocytic leukaemia refractory | 25.81 | 13.52 | 8 | 72744 | 79 | 53276235 |
Metastasis | 25.70 | 13.52 | 32 | 72720 | 4699 | 53271615 |
Ill-defined disorder | 25.67 | 13.52 | 18 | 72734 | 49426 | 53226888 |
Gastric disorder | 25.61 | 13.52 | 5 | 72747 | 30160 | 53246154 |
Escherichia infection | 25.51 | 13.52 | 53 | 72699 | 11997 | 53264317 |
Primary immunodeficiency syndrome | 25.49 | 13.52 | 7 | 72745 | 43 | 53276271 |
Premature delivery | 25.47 | 13.52 | 86 | 72666 | 26018 | 53250296 |
International normalised ratio increased | 25.31 | 13.52 | 17 | 72735 | 47744 | 53228570 |
Abdominal neoplasm | 25.31 | 13.52 | 11 | 72741 | 298 | 53276016 |
B-cell type acute leukaemia | 25.26 | 13.52 | 9 | 72743 | 141 | 53276173 |
Infusion related reaction | 25.23 | 13.52 | 118 | 72634 | 155839 | 53120475 |
Toxic cardiomyopathy | 25.20 | 13.52 | 9 | 72743 | 142 | 53276172 |
Traumatic lung injury | 25.14 | 13.52 | 19 | 72733 | 1504 | 53274810 |
Atypical haemolytic uraemic syndrome | 25.04 | 13.52 | 13 | 72739 | 528 | 53275786 |
Clostridium difficile infection | 24.71 | 13.52 | 89 | 72663 | 27804 | 53248510 |
Influenza | 24.46 | 13.52 | 59 | 72693 | 95320 | 53180994 |
Hepatitis C RNA increased | 24.32 | 13.52 | 9 | 72743 | 158 | 53276156 |
Chronic myelomonocytic leukaemia | 24.27 | 13.52 | 11 | 72741 | 330 | 53275984 |
Chronic hepatitis | 24.18 | 13.52 | 15 | 72737 | 859 | 53275455 |
Alveolar soft part sarcoma | 24.18 | 13.52 | 8 | 72744 | 99 | 53276215 |
Rhabdomyosarcoma recurrent | 24.17 | 13.52 | 6 | 72746 | 23 | 53276291 |
Multiple sclerosis | 24.13 | 13.52 | 4 | 72748 | 27149 | 53249165 |
Bone marrow transplant | 24.10 | 13.52 | 14 | 72738 | 711 | 53275603 |
Gait disturbance | 24.06 | 13.52 | 123 | 72629 | 158719 | 53117595 |
Intestinal perforation | 24.03 | 13.52 | 50 | 72702 | 11330 | 53264984 |
Uterine enlargement | 24.00 | 13.52 | 17 | 72735 | 1217 | 53275097 |
Blood pressure systolic increased | 23.92 | 13.52 | 9 | 72743 | 35168 | 53241146 |
Pulmonary toxicity | 23.91 | 13.52 | 33 | 72719 | 5358 | 53270956 |
IIIrd nerve paralysis | 23.88 | 13.52 | 14 | 72738 | 723 | 53275591 |
Streptococcus test positive | 23.78 | 13.52 | 17 | 72735 | 1235 | 53275079 |
Geotrichum infection | 23.75 | 13.52 | 12 | 72740 | 460 | 53275854 |
Soft tissue infection | 23.70 | 13.52 | 21 | 72731 | 2080 | 53274234 |
Angioedema | 23.64 | 13.52 | 14 | 72738 | 42062 | 53234252 |
Localised infection | 23.60 | 13.52 | 4 | 72748 | 26712 | 53249602 |
Metastases to meninges | 23.37 | 13.52 | 21 | 72731 | 2118 | 53274196 |
Escherichia sepsis | 23.32 | 13.52 | 30 | 72722 | 4551 | 53271763 |
Dry skin | 23.31 | 13.52 | 17 | 72735 | 45743 | 53230571 |
Flatulence | 23.29 | 13.52 | 7 | 72745 | 31510 | 53244804 |
Mantle cell lymphoma | 23.26 | 13.52 | 13 | 72739 | 613 | 53275701 |
Hypertransaminasaemia | 23.17 | 13.52 | 28 | 72724 | 3988 | 53272326 |
Fluid retention | 23.12 | 13.52 | 24 | 72728 | 54377 | 53221937 |
Blood immunoglobulin G decreased | 22.81 | 13.52 | 20 | 72732 | 1953 | 53274361 |
Weight decreased | 22.62 | 13.52 | 208 | 72544 | 234740 | 53041574 |
T-cell type acute leukaemia | 22.59 | 13.52 | 7 | 72745 | 69 | 53276245 |
COVID-19 | 22.59 | 13.52 | 105 | 72647 | 36783 | 53239531 |
Head injury | 22.53 | 13.52 | 4 | 72748 | 25829 | 53250485 |
Gastric stenosis | 22.50 | 13.52 | 7 | 72745 | 70 | 53276244 |
Hereditary motor and sensory neuropathy | 22.50 | 13.52 | 7 | 72745 | 70 | 53276244 |
Rash pruritic | 22.48 | 13.52 | 21 | 72731 | 49989 | 53226325 |
Partial seizures | 22.47 | 13.52 | 32 | 72720 | 5348 | 53270966 |
Balance disorder | 22.37 | 13.52 | 41 | 72711 | 73166 | 53203148 |
Neutropenic infection | 22.28 | 13.52 | 16 | 72736 | 1171 | 53275143 |
Renal replacement therapy | 22.26 | 13.52 | 6 | 72746 | 34 | 53276280 |
Dry eye | 22.23 | 13.52 | 9 | 72743 | 33635 | 53242679 |
Visual impairment | 22.13 | 13.52 | 41 | 72711 | 72871 | 53203443 |
Nervous system disorder | 22.11 | 13.52 | 63 | 72689 | 17401 | 53258913 |
Parainfluenzae virus infection | 22.10 | 13.52 | 20 | 72732 | 2036 | 53274278 |
Axonal neuropathy | 22.02 | 13.52 | 15 | 72737 | 1008 | 53275306 |
Alveolar rhabdomyosarcoma | 21.97 | 13.52 | 6 | 72746 | 36 | 53276278 |
Alanine aminotransferase increased | 21.93 | 13.52 | 212 | 72540 | 94883 | 53181431 |
Erythema | 21.87 | 13.52 | 125 | 72627 | 156844 | 53119470 |
Mucosal infection | 21.85 | 13.52 | 8 | 72744 | 136 | 53276178 |
Wrong technique in product usage process | 21.77 | 13.52 | 30 | 72722 | 60002 | 53216312 |
Epstein Barr virus positive mucocutaneous ulcer | 21.73 | 13.52 | 10 | 72742 | 311 | 53276003 |
Throat irritation | 21.72 | 13.52 | 8 | 72744 | 31673 | 53244641 |
Polyomavirus-associated nephropathy | 21.69 | 13.52 | 18 | 72734 | 1631 | 53274683 |
Renal vein thrombosis | 21.64 | 13.52 | 10 | 72742 | 314 | 53276000 |
Generalised tonic-clonic seizure | 21.55 | 13.52 | 87 | 72665 | 28671 | 53247643 |
Treatment failure | 21.45 | 13.52 | 96 | 72656 | 128307 | 53148007 |
Retinal pigment epitheliopathy | 21.41 | 13.52 | 9 | 72743 | 224 | 53276090 |
Paraplegia | 21.38 | 13.52 | 22 | 72730 | 2625 | 53273689 |
Platelet transfusion | 21.19 | 13.52 | 13 | 72739 | 730 | 53275584 |
Serotonin syndrome | 21.15 | 13.52 | 5 | 72747 | 26401 | 53249913 |
Jejunal stenosis | 21.05 | 13.52 | 6 | 72746 | 43 | 53276271 |
Duodenal stenosis | 21.05 | 13.52 | 12 | 72740 | 588 | 53275726 |
Cataract | 20.96 | 13.52 | 22 | 72730 | 49598 | 53226716 |
Blood stem cell transplant failure | 20.94 | 13.52 | 8 | 72744 | 154 | 53276160 |
Skin discolouration | 20.80 | 13.52 | 11 | 72741 | 35181 | 53241133 |
Angioimmunoblastic T-cell lymphoma | 20.79 | 13.52 | 8 | 72744 | 157 | 53276157 |
Peritonitis viral | 20.48 | 13.52 | 6 | 72746 | 48 | 53276266 |
Hepatic function abnormal | 20.41 | 13.52 | 102 | 72650 | 36797 | 53239517 |
General physical health deterioration | 20.32 | 13.52 | 297 | 72455 | 146645 | 53129669 |
Pharyngeal inflammation | 20.29 | 13.52 | 12 | 72740 | 630 | 53275684 |
Granulocytopenia | 20.24 | 13.52 | 31 | 72721 | 5529 | 53270785 |
Joint injury | 20.22 | 13.52 | 3 | 72749 | 22097 | 53254217 |
Limb discomfort | 20.11 | 13.52 | 5 | 72747 | 25517 | 53250797 |
Haemoglobin abnormal | 20.10 | 13.52 | 28 | 72724 | 4586 | 53271728 |
Chronic lymphocytic leukaemia | 20.09 | 13.52 | 23 | 72729 | 3093 | 53273221 |
Post lumbar puncture syndrome | 20 | 13.52 | 12 | 72740 | 647 | 53275667 |
Disturbance in attention | 19.95 | 13.52 | 11 | 72741 | 34372 | 53241942 |
Abnormal behaviour | 19.93 | 13.52 | 3 | 72749 | 21863 | 53254451 |
Blood bilirubin increased | 19.93 | 13.52 | 99 | 72653 | 35631 | 53240683 |
Tooth disorder | 19.86 | 13.52 | 5 | 72747 | 25307 | 53251007 |
Hepatitis acute | 19.80 | 13.52 | 40 | 72712 | 8876 | 53267438 |
Cardiopulmonary failure | 19.78 | 13.52 | 25 | 72727 | 3726 | 53272588 |
Congenital retinoblastoma | 19.78 | 13.52 | 5 | 72747 | 21 | 53276293 |
Paranasal sinus mucosal hypertrophy | 19.78 | 13.52 | 5 | 72747 | 21 | 53276293 |
Pseudomonal bacteraemia | 19.78 | 13.52 | 16 | 72736 | 1399 | 53274915 |
Pneumonia influenzal | 19.76 | 13.52 | 17 | 72735 | 1618 | 53274696 |
Chronic obstructive pulmonary disease | 19.75 | 13.52 | 33 | 72719 | 61040 | 53215274 |
Tachycardia | 19.69 | 13.52 | 230 | 72522 | 107982 | 53168332 |
Nephropathy toxic | 19.68 | 13.52 | 39 | 72713 | 8533 | 53267781 |
Death | 19.61 | 13.52 | 356 | 72396 | 356876 | 52919438 |
Brain injury | 19.60 | 13.52 | 33 | 72719 | 6372 | 53269942 |
Central nervous system enteroviral infection | 19.59 | 13.52 | 5 | 72747 | 22 | 53276292 |
Acne | 19.59 | 13.52 | 3 | 72749 | 21583 | 53254731 |
Graft versus host disease | 19.59 | 13.52 | 35 | 72717 | 7087 | 53269227 |
Haemoglobin decreased | 19.57 | 13.52 | 279 | 72473 | 137028 | 53139286 |
Neutrophil count abnormal | 19.55 | 13.52 | 21 | 72731 | 2633 | 53273681 |
Underdose | 19.51 | 13.52 | 3 | 72749 | 21519 | 53254795 |
Acidosis | 19.48 | 13.52 | 46 | 72706 | 11346 | 53264968 |
Haematocolpos | 19.47 | 13.52 | 6 | 72746 | 58 | 53276256 |
Ocular lymphoma | 19.47 | 13.52 | 6 | 72746 | 58 | 53276256 |
Swollen tongue | 19.45 | 13.52 | 9 | 72743 | 31071 | 53245243 |
Restlessness | 19.41 | 13.52 | 7 | 72745 | 28080 | 53248234 |
Delayed puberty | 19.40 | 13.52 | 7 | 72745 | 114 | 53276200 |
Iris atrophy | 19.38 | 13.52 | 6 | 72746 | 59 | 53276255 |
Dysgeusia | 19.33 | 13.52 | 18 | 72734 | 42913 | 53233401 |
Tremor | 19.25 | 13.52 | 97 | 72655 | 125639 | 53150675 |
Quadriparesis | 19.23 | 13.52 | 18 | 72734 | 1913 | 53274401 |
Amnesia | 19.22 | 13.52 | 20 | 72732 | 45268 | 53231046 |
Osteoporosis | 19.18 | 13.52 | 21 | 72731 | 46439 | 53229875 |
Cerebral artery thrombosis | 19.08 | 13.52 | 10 | 72742 | 414 | 53275900 |
Rectal adenoma | 19.03 | 13.52 | 6 | 72746 | 63 | 53276251 |
Hypoglycaemia | 18.98 | 13.52 | 32 | 72720 | 58981 | 53217333 |
Interstitial lung disease | 18.98 | 13.52 | 141 | 72611 | 58481 | 53217833 |
Skin ulcer | 18.95 | 13.52 | 13 | 72739 | 36106 | 53240208 |
Foot fracture | 18.92 | 13.52 | 3 | 72749 | 21036 | 53255278 |
Rectal fissure | 18.91 | 13.52 | 11 | 72741 | 560 | 53275754 |
Enteral nutrition | 18.86 | 13.52 | 6 | 72746 | 65 | 53276249 |
Neurological decompensation | 18.85 | 13.52 | 20 | 72732 | 2472 | 53273842 |
Primary mediastinal large B-cell lymphoma recurrent | 18.77 | 13.52 | 6 | 72746 | 66 | 53276248 |
Adverse event | 18.74 | 13.52 | 17 | 72735 | 41044 | 53235270 |
Hepatosplenomegaly | 18.68 | 13.52 | 20 | 72732 | 2498 | 53273816 |
Anaesthesia | 18.63 | 13.52 | 10 | 72742 | 435 | 53275879 |
Leukaemic infiltration | 18.60 | 13.52 | 5 | 72747 | 28 | 53276286 |
Inflammatory myofibroblastic tumour | 18.60 | 13.52 | 5 | 72747 | 28 | 53276286 |
Gastrointestinal disorder | 18.42 | 13.52 | 62 | 72690 | 89942 | 53186372 |
Tracheo-oesophageal fistula | 18.42 | 13.52 | 11 | 72741 | 588 | 53275726 |
Illness | 18.42 | 13.52 | 4 | 72748 | 22392 | 53253922 |
Lipase increased | 18.41 | 13.52 | 40 | 72712 | 9338 | 53266976 |
Meningoencephalitis herpetic | 18.35 | 13.52 | 14 | 72738 | 1124 | 53275190 |
Oedema due to cardiac disease | 18.31 | 13.52 | 5 | 72747 | 30 | 53276284 |
Coronavirus infection | 18.29 | 13.52 | 22 | 72730 | 3118 | 53273196 |
Vulvovaginitis | 18.26 | 13.52 | 9 | 72743 | 327 | 53275987 |
Enterococcus test positive | 18.16 | 13.52 | 14 | 72738 | 1141 | 53275173 |
Heart rate irregular | 18.12 | 13.52 | 3 | 72749 | 20381 | 53255933 |
Peripheral sensorimotor neuropathy | 18.07 | 13.52 | 15 | 72737 | 1360 | 53274954 |
Gastrointestinal toxicity | 17.97 | 13.52 | 27 | 72725 | 4735 | 53271579 |
Acute leukaemia | 17.94 | 13.52 | 14 | 72738 | 1162 | 53275152 |
Blood immunoglobulin A decreased | 17.86 | 13.52 | 9 | 72743 | 343 | 53275971 |
Vulvovaginal inflammation | 17.84 | 13.52 | 11 | 72741 | 623 | 53275691 |
Hypophosphataemia | 17.79 | 13.52 | 38 | 72714 | 8767 | 53267547 |
Endocarditis | 17.78 | 13.52 | 29 | 72723 | 5455 | 53270859 |
Abdominal compartment syndrome | 17.76 | 13.52 | 11 | 72741 | 628 | 53275686 |
SARS-CoV-2 test negative | 17.72 | 13.52 | 9 | 72743 | 349 | 53275965 |
Papillary thyroid cancer | 17.67 | 13.52 | 18 | 72734 | 2122 | 53274192 |
Adenovirus infection | 17.62 | 13.52 | 22 | 72730 | 3240 | 53273074 |
Staphylococcus test positive | 17.62 | 13.52 | 24 | 72728 | 3849 | 53272465 |
Acute monocytic leukaemia | 17.59 | 13.52 | 6 | 72746 | 82 | 53276232 |
Autonomic neuropathy | 17.58 | 13.52 | 13 | 72739 | 995 | 53275319 |
Device issue | 17.54 | 13.52 | 4 | 72748 | 21654 | 53254660 |
Urinary tract infection bacterial | 17.53 | 13.52 | 26 | 72726 | 4508 | 53271806 |
Primary cardiac lymphoma | 17.52 | 13.52 | 5 | 72747 | 36 | 53276278 |
Cardiac disorder | 17.50 | 13.52 | 23 | 72729 | 46943 | 53229371 |
Chronic hepatitis B | 17.43 | 13.52 | 8 | 72744 | 247 | 53276067 |
Myeloproliferative neoplasm | 17.43 | 13.52 | 10 | 72742 | 496 | 53275818 |
Blood magnesium decreased | 17.34 | 13.52 | 45 | 72707 | 11769 | 53264545 |
Pyloric stenosis | 17.30 | 13.52 | 9 | 72743 | 367 | 53275947 |
Splenic necrosis | 17.17 | 13.52 | 5 | 72747 | 39 | 53276275 |
Candida sepsis | 17.14 | 13.52 | 15 | 72737 | 1461 | 53274853 |
Pulmonary vascular disorder | 17.10 | 13.52 | 9 | 72743 | 376 | 53275938 |
Precursor T-lymphoblastic lymphoma/leukaemia | 17.06 | 13.52 | 5 | 72747 | 40 | 53276274 |
Postictal state | 17.04 | 13.52 | 13 | 72739 | 1043 | 53275271 |
Ear infection | 17.00 | 13.52 | 7 | 72745 | 25893 | 53250421 |
Listeria encephalitis | 16.97 | 13.52 | 8 | 72744 | 263 | 53276051 |
Hyporeflexia | 16.97 | 13.52 | 17 | 72735 | 1965 | 53274349 |
C-reactive protein abnormal | 16.96 | 13.52 | 7 | 72745 | 25863 | 53250451 |
Bacillus test positive | 16.96 | 13.52 | 5 | 72747 | 41 | 53276273 |
Hyperkalaemia | 16.92 | 13.52 | 30 | 72722 | 54226 | 53222088 |
Myelitis | 16.89 | 13.52 | 14 | 72738 | 1267 | 53275047 |
Haemangioma-thrombocytopenia syndrome | 16.80 | 13.52 | 3 | 72749 | 0 | 53276314 |
Bone marrow leukaemic cell infiltration | 16.80 | 13.52 | 3 | 72749 | 0 | 53276314 |
Blast crisis in myelogenous leukaemia | 16.79 | 13.52 | 10 | 72742 | 532 | 53275782 |
Chromosomal deletion | 16.64 | 13.52 | 5 | 72747 | 44 | 53276270 |
Urethritis | 16.64 | 13.52 | 8 | 72744 | 275 | 53276039 |
Flagellate dermatitis | 16.63 | 13.52 | 7 | 72745 | 175 | 53276139 |
Astrocytoma | 16.61 | 13.52 | 6 | 72746 | 98 | 53276216 |
Diffuse large B-cell lymphoma stage IV | 16.59 | 13.52 | 8 | 72744 | 277 | 53276037 |
Aborted pregnancy | 16.54 | 13.52 | 5 | 72747 | 45 | 53276269 |
Pancreatitis acute | 16.49 | 13.52 | 75 | 72677 | 26034 | 53250280 |
Coronary artery disease | 16.29 | 13.52 | 13 | 72739 | 33424 | 53242890 |
Subileus | 16.28 | 13.52 | 21 | 72731 | 3195 | 53273119 |
Meningism | 16.24 | 13.52 | 9 | 72743 | 417 | 53275897 |
Therapy cessation | 16.21 | 13.52 | 9 | 72743 | 28016 | 53248298 |
Encopresis | 16.18 | 13.52 | 6 | 72746 | 106 | 53276208 |
Tachypnoea | 16.15 | 13.52 | 53 | 72699 | 15801 | 53260513 |
Central nervous system leukaemia | 16.13 | 13.52 | 6 | 72746 | 107 | 53276207 |
Lymphocytosis | 16.06 | 13.52 | 18 | 72734 | 2365 | 53273949 |
Pancreatic pseudocyst | 16.02 | 13.52 | 10 | 72742 | 579 | 53275735 |
Beta 2 microglobulin decreased | 15.98 | 13.52 | 4 | 72748 | 16 | 53276298 |
Optic glioma | 15.98 | 13.52 | 4 | 72748 | 16 | 53276298 |
Perirectal abscess | 15.94 | 13.52 | 12 | 72740 | 944 | 53275370 |
Refractory cytopenia with unilineage dysplasia | 15.93 | 13.52 | 10 | 72742 | 585 | 53275729 |
B-lymphocyte count abnormal | 15.90 | 13.52 | 5 | 72747 | 52 | 53276262 |
Hyperviscosity syndrome | 15.86 | 13.52 | 7 | 72745 | 197 | 53276117 |
Erythropenia | 15.82 | 13.52 | 7 | 72745 | 198 | 53276116 |
Intestinal dilatation | 15.80 | 13.52 | 15 | 72737 | 1623 | 53274691 |
Eye irritation | 15.78 | 13.52 | 3 | 72749 | 18446 | 53257868 |
Vascular compression | 15.78 | 13.52 | 6 | 72746 | 114 | 53276200 |
Intra-abdominal haemorrhage | 15.76 | 13.52 | 18 | 72734 | 2414 | 53273900 |
Swelling face | 15.76 | 13.52 | 34 | 72718 | 57134 | 53219180 |
Vaccination failure | 15.76 | 13.52 | 7 | 72745 | 200 | 53276114 |
Vertigo | 15.75 | 13.52 | 33 | 72719 | 56048 | 53220266 |
Respiratory syncytial virus infection | 15.71 | 13.52 | 27 | 72725 | 5301 | 53271013 |
Metastases to peritoneum | 15.65 | 13.52 | 20 | 72732 | 3015 | 53273299 |
Tachycardia induced cardiomyopathy | 15.65 | 13.52 | 5 | 72747 | 55 | 53276259 |
COVID-19 pneumonia | 15.62 | 13.52 | 32 | 72720 | 7171 | 53269143 |
Pericardial effusion | 15.51 | 13.52 | 76 | 72676 | 27202 | 53249112 |
Cauda equina syndrome | 15.49 | 13.52 | 11 | 72741 | 791 | 53275523 |
Hepatitis B surface antigen positive | 15.41 | 13.52 | 5 | 72747 | 58 | 53276256 |
Eosinophilia | 15.29 | 13.52 | 5 | 72747 | 21330 | 53254984 |
Porphyria non-acute | 15.27 | 13.52 | 8 | 72744 | 331 | 53275983 |
Malignant neoplasm of orbit | 15.26 | 13.52 | 4 | 72748 | 20 | 53276294 |
Joint range of motion decreased | 15.19 | 13.52 | 3 | 72749 | 17953 | 53258361 |
Respiratory arrest | 15.17 | 13.52 | 14 | 72738 | 33526 | 53242788 |
Asthenia | 15.12 | 13.52 | 355 | 72397 | 343235 | 52933079 |
Klebsiella test positive | 15.12 | 13.52 | 12 | 72740 | 1021 | 53275293 |
Visceral leishmaniasis | 15.02 | 13.52 | 9 | 72743 | 484 | 53275830 |
Sopor | 15.01 | 13.52 | 5 | 72747 | 21079 | 53255235 |
Adult T-cell lymphoma/leukaemia | 14.84 | 13.52 | 8 | 72744 | 351 | 53275963 |
Osmotic demyelination syndrome | 14.79 | 13.52 | 10 | 72742 | 664 | 53275650 |
Withdrawal syndrome | 14.79 | 13.52 | 4 | 72748 | 19297 | 53257017 |
Pneumonitis | 14.76 | 13.52 | 82 | 72670 | 30806 | 53245508 |
Hydrocephalus | 14.74 | 13.52 | 26 | 72726 | 5210 | 53271104 |
Rash macular | 14.74 | 13.52 | 5 | 72747 | 20842 | 53255472 |
Antithrombin III deficiency | 14.72 | 13.52 | 3 | 72749 | 3 | 53276311 |
Ventriculo-peritoneal shunt | 14.72 | 13.52 | 3 | 72749 | 3 | 53276311 |
Vulvovaginal adhesion | 14.72 | 13.52 | 3 | 72749 | 3 | 53276311 |
Vaginal obstruction | 14.72 | 13.52 | 3 | 72749 | 3 | 53276311 |
Pancreatic infarction | 14.72 | 13.52 | 3 | 72749 | 3 | 53276311 |
Heart rate increased | 14.69 | 13.52 | 60 | 72692 | 82255 | 53194059 |
Chronic graft versus host disease | 14.68 | 13.52 | 20 | 72732 | 3208 | 53273106 |
Cheyne-Stokes respiration | 14.67 | 13.52 | 6 | 72746 | 139 | 53276175 |
Febrile infection | 14.67 | 13.52 | 13 | 72739 | 1288 | 53275026 |
Liver function test abnormal | 14.61 | 13.52 | 27 | 72725 | 48044 | 53228270 |
Cranial nerve disorder | 14.53 | 13.52 | 8 | 72744 | 366 | 53275948 |
Malnutrition | 14.51 | 13.52 | 49 | 72703 | 14822 | 53261492 |
Gastroenteritis salmonella | 14.45 | 13.52 | 9 | 72743 | 519 | 53275795 |
Neonatal respiratory distress | 14.44 | 13.52 | 7 | 72745 | 245 | 53276069 |
Electrocardiogram QT prolonged | 14.37 | 13.52 | 35 | 72717 | 56368 | 53219946 |
Streptococcal bacteraemia | 14.33 | 13.52 | 14 | 72738 | 1570 | 53274744 |
Anal ulcer | 14.31 | 13.52 | 9 | 72743 | 528 | 53275786 |
Intervertebral disc protrusion | 14.29 | 13.52 | 6 | 72746 | 21939 | 53254375 |
Shock | 14.27 | 13.52 | 66 | 72686 | 23073 | 53253241 |
Eyelid ptosis | 14.25 | 13.52 | 29 | 72723 | 6468 | 53269846 |
Acute graft versus host disease | 14.23 | 13.52 | 23 | 72729 | 4294 | 53272020 |
Amenorrhoea | 14.12 | 13.52 | 36 | 72716 | 9313 | 53267001 |
Ocular hyperaemia | 14.12 | 13.52 | 6 | 72746 | 21785 | 53254529 |
Osteosarcoma | 14.10 | 13.52 | 6 | 72746 | 154 | 53276160 |
Gastrointestinal inflammation | 14.08 | 13.52 | 24 | 72728 | 4682 | 53271632 |
Brain herniation | 14.07 | 13.52 | 20 | 72732 | 3336 | 53272978 |
Fungal test positive | 14.05 | 13.52 | 9 | 72743 | 545 | 53275769 |
Peripheral T-cell lymphoma unspecified | 14.03 | 13.52 | 7 | 72745 | 261 | 53276053 |
Sciatica | 14.01 | 13.52 | 6 | 72746 | 21687 | 53254627 |
Cancer in remission | 13.99 | 13.52 | 4 | 72748 | 29 | 53276285 |
Ecthyma | 13.96 | 13.52 | 7 | 72745 | 264 | 53276050 |
Iron deficiency anaemia | 13.96 | 13.52 | 4 | 72748 | 18576 | 53257738 |
Upper limb fracture | 13.94 | 13.52 | 3 | 72749 | 16904 | 53259410 |
Dysaesthesia | 13.91 | 13.52 | 22 | 72730 | 4033 | 53272281 |
Breast cancer | 13.90 | 13.52 | 29 | 72723 | 49329 | 53226985 |
Viral haemorrhagic cystitis | 13.80 | 13.52 | 10 | 72742 | 742 | 53275572 |
Sarcoidosis | 13.78 | 13.52 | 26 | 72726 | 5488 | 53270826 |
Drug dependence | 13.77 | 13.52 | 6 | 72746 | 21466 | 53254848 |
Encephalitis cytomegalovirus | 13.76 | 13.52 | 9 | 72743 | 565 | 53275749 |
Enterocolitis | 13.75 | 13.52 | 30 | 72722 | 7022 | 53269292 |
Bacillus infection | 13.75 | 13.52 | 9 | 72743 | 566 | 53275748 |
Human herpesvirus 7 infection | 13.71 | 13.52 | 5 | 72747 | 84 | 53276230 |
Eye pain | 13.69 | 13.52 | 13 | 72739 | 30712 | 53245602 |
Otitis media acute | 13.68 | 13.52 | 11 | 72741 | 953 | 53275361 |
Meningitis coccidioides | 13.65 | 13.52 | 4 | 72748 | 32 | 53276282 |
Listeriosis | 13.64 | 13.52 | 13 | 72739 | 1414 | 53274900 |
Obliterative bronchiolitis | 13.61 | 13.52 | 15 | 72737 | 1935 | 53274379 |
Injection site rash | 13.55 | 13.52 | 3 | 72749 | 16576 | 53259738 |
Campylobacter infection | 13.54 | 13.52 | 10 | 72742 | 764 | 53275550 |
Fusobacterium infection | 13.54 | 13.52 | 4 | 72748 | 33 | 53276281 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 4167.55 | 12.98 | 3144 | 91435 | 116422 | 32302525 |
Neutropenia | 1500.13 | 12.98 | 1950 | 92629 | 140225 | 32278722 |
Hepatitis B | 687.36 | 12.98 | 346 | 94233 | 5995 | 32412952 |
Mucosal inflammation | 666.54 | 12.98 | 641 | 93938 | 32793 | 32386154 |
Product use in unapproved indication | 642.20 | 12.98 | 1010 | 93569 | 86194 | 32332753 |
Second primary malignancy | 568.32 | 12.98 | 314 | 94265 | 6627 | 32412320 |
Febrile bone marrow aplasia | 561.23 | 12.98 | 333 | 94246 | 8082 | 32410865 |
Diffuse large B-cell lymphoma recurrent | 554.54 | 12.98 | 228 | 94351 | 2394 | 32416553 |
Bone marrow failure | 522.88 | 12.98 | 538 | 94041 | 29866 | 32389081 |
Myelodysplastic syndrome | 510.49 | 12.98 | 441 | 94138 | 19597 | 32399350 |
Myelosuppression | 484.63 | 12.98 | 343 | 94236 | 11333 | 32407614 |
Haematotoxicity | 461.95 | 12.98 | 272 | 94307 | 6504 | 32412443 |
Posterior reversible encephalopathy syndrome | 441.27 | 12.98 | 300 | 94279 | 9276 | 32409671 |
Hepatitis B reactivation | 438.91 | 12.98 | 210 | 94369 | 3239 | 32415708 |
Pancytopenia | 435.05 | 12.98 | 874 | 93705 | 90361 | 32328586 |
Tumour lysis syndrome | 434.40 | 12.98 | 351 | 94228 | 14196 | 32404751 |
Diffuse large B-cell lymphoma | 423.33 | 12.98 | 279 | 94300 | 8183 | 32410764 |
Venoocclusive liver disease | 418.24 | 12.98 | 263 | 94316 | 7102 | 32411845 |
Acute myeloid leukaemia | 401.65 | 12.98 | 378 | 94201 | 18796 | 32400151 |
Hypofibrinogenaemia | 325.17 | 12.98 | 138 | 94441 | 1578 | 32417369 |
Pyrexia | 324.66 | 12.98 | 1804 | 92775 | 318164 | 32100783 |
Progressive multifocal leukoencephalopathy | 308.12 | 12.98 | 241 | 94338 | 9290 | 32409657 |
Fall | 280.75 | 12.98 | 110 | 94469 | 196091 | 32222856 |
Sepsis | 269.24 | 12.98 | 1042 | 93537 | 157792 | 32261155 |
Thrombocytopenia | 268.79 | 12.98 | 994 | 93585 | 147305 | 32271642 |
Pneumocystis jirovecii pneumonia | 263.04 | 12.98 | 299 | 94280 | 18571 | 32400376 |
Off label use | 260.12 | 12.98 | 1649 | 92930 | 304671 | 32114276 |
Leukopenia | 254.66 | 12.98 | 549 | 94030 | 59573 | 32359374 |
Acute lymphocytic leukaemia | 247.09 | 12.98 | 144 | 94435 | 3374 | 32415573 |
Product dose omission issue | 245.08 | 12.98 | 13 | 94566 | 102562 | 32316385 |
Acute lymphocytic leukaemia recurrent | 237.86 | 12.98 | 134 | 94445 | 2938 | 32416009 |
Neoplasm progression | 235.07 | 12.98 | 288 | 94291 | 19370 | 32399577 |
Cytomegalovirus chorioretinitis | 233.14 | 12.98 | 140 | 94439 | 3472 | 32415475 |
Septic shock | 229.59 | 12.98 | 573 | 94006 | 68416 | 32350531 |
Neuropathy peripheral | 228.03 | 12.98 | 612 | 93967 | 76370 | 32342577 |
Neutrophil count decreased | 223.60 | 12.98 | 451 | 94128 | 46688 | 32372259 |
Death | 217.98 | 12.98 | 496 | 94083 | 382021 | 32036926 |
Diffuse large B-cell lymphoma refractory | 213.34 | 12.98 | 86 | 94493 | 854 | 32418093 |
Disease progression | 207.33 | 12.98 | 639 | 93940 | 86223 | 32332724 |
Cytopenia | 206.09 | 12.98 | 196 | 94383 | 9868 | 32409079 |
Neutropenic sepsis | 202.56 | 12.98 | 216 | 94363 | 12483 | 32406464 |
Fatigue | 194.65 | 12.98 | 461 | 94118 | 350240 | 32068707 |
Dizziness | 193.36 | 12.98 | 195 | 94384 | 209423 | 32209524 |
Arthralgia | 187.59 | 12.98 | 99 | 94480 | 148349 | 32270598 |
B-cell lymphoma recurrent | 179.08 | 12.98 | 69 | 94510 | 601 | 32418346 |
Rash | 178.36 | 12.98 | 208 | 94371 | 209125 | 32209822 |
Acquired gene mutation | 177.35 | 12.98 | 82 | 94497 | 1165 | 32417782 |
Myocardial infarction | 170.65 | 12.98 | 76 | 94503 | 125600 | 32293347 |
Post transplant lymphoproliferative disorder | 162.01 | 12.98 | 135 | 94444 | 5699 | 32413248 |
Leukoencephalopathy | 156.97 | 12.98 | 115 | 94464 | 4010 | 32414937 |
Hyperbilirubinaemia | 156.70 | 12.98 | 224 | 94355 | 17506 | 32401441 |
Mantle cell lymphoma recurrent | 152.80 | 12.98 | 57 | 94522 | 450 | 32418497 |
Dyspnoea | 149.19 | 12.98 | 547 | 94032 | 361498 | 32057449 |
Hypogammaglobulinaemia | 147.30 | 12.98 | 131 | 94448 | 6045 | 32412902 |
Cardiotoxicity | 145.05 | 12.98 | 118 | 94461 | 4814 | 32414133 |
White blood cell count decreased | 145.04 | 12.98 | 587 | 93992 | 90611 | 32328336 |
Hypertriglyceridaemia | 143.83 | 12.98 | 151 | 94428 | 8568 | 32410379 |
Pain | 141.52 | 12.98 | 204 | 94375 | 187352 | 32231595 |
Insomnia | 140.47 | 12.98 | 58 | 94521 | 100290 | 32318657 |
Neoplasm recurrence | 139.04 | 12.98 | 82 | 94497 | 1965 | 32416982 |
Muscle spasms | 138.49 | 12.98 | 20 | 94559 | 70398 | 32348549 |
Peripheral swelling | 133.05 | 12.98 | 20 | 94559 | 68325 | 32350622 |
Joint swelling | 132.10 | 12.98 | 4 | 94575 | 51731 | 32367216 |
Anxiety | 131.95 | 12.98 | 57 | 94522 | 95948 | 32322999 |
Therapy partial responder | 130.54 | 12.98 | 111 | 94468 | 4819 | 32414128 |
Aspergillus infection | 129.42 | 12.98 | 164 | 94415 | 11410 | 32407537 |
Rhabdomyolysis | 127.96 | 12.98 | 21 | 94558 | 67244 | 32351703 |
Pruritus | 126.38 | 12.98 | 113 | 94466 | 128589 | 32290358 |
Neurotoxicity | 125.32 | 12.98 | 185 | 94394 | 14885 | 32404062 |
Bacteraemia | 124.93 | 12.98 | 201 | 94378 | 17432 | 32401515 |
Depression | 123.60 | 12.98 | 64 | 94515 | 96996 | 32321951 |
Overdose | 122.39 | 12.98 | 50 | 94529 | 87027 | 32331920 |
Lymphadenopathy | 117.64 | 12.98 | 250 | 94329 | 26832 | 32392115 |
Malaise | 117.28 | 12.98 | 210 | 94369 | 176928 | 32242019 |
Lymphopenia | 113.83 | 12.98 | 173 | 94406 | 14283 | 32404664 |
Rheumatoid arthritis | 111.75 | 12.98 | 4 | 94575 | 44540 | 32374407 |
Disease recurrence | 110.92 | 12.98 | 181 | 94398 | 15883 | 32403064 |
Central nervous system lymphoma | 110.55 | 12.98 | 55 | 94524 | 927 | 32418020 |
Osteonecrosis | 110.35 | 12.98 | 184 | 94395 | 16438 | 32402509 |
Polyneuropathy | 109.55 | 12.98 | 162 | 94417 | 13053 | 32405894 |
Hepatic failure | 107.86 | 12.98 | 286 | 94293 | 35394 | 32383553 |
Weight increased | 106.76 | 12.98 | 55 | 94524 | 83608 | 32335339 |
Candida infection | 104.93 | 12.98 | 181 | 94398 | 16622 | 32402325 |
Stomatitis | 104.38 | 12.98 | 305 | 94274 | 39924 | 32379023 |
Epstein-Barr virus infection | 103.30 | 12.98 | 115 | 94464 | 6975 | 32411972 |
Malignant neoplasm progression | 100.86 | 12.98 | 474 | 94105 | 78022 | 32340925 |
Myelopathy | 100.68 | 12.98 | 67 | 94512 | 1996 | 32416951 |
Inappropriate schedule of product administration | 100.12 | 12.98 | 9 | 94570 | 45816 | 32373131 |
Feeling abnormal | 98.30 | 12.98 | 27 | 94552 | 60396 | 32358551 |
Suicidal ideation | 97.02 | 12.98 | 3 | 94576 | 38080 | 32380867 |
Somnolence | 96.16 | 12.98 | 96 | 94483 | 103701 | 32315246 |
Myalgia | 95.59 | 12.98 | 59 | 94520 | 81171 | 32337776 |
B-cell lymphoma | 94.63 | 12.98 | 90 | 94489 | 4529 | 32414418 |
Venoocclusive disease | 94.32 | 12.98 | 72 | 94507 | 2674 | 32416273 |
Hospitalisation | 93.77 | 12.98 | 15 | 94564 | 48956 | 32369991 |
Coronary artery disease | 93.46 | 12.98 | 16 | 94563 | 49690 | 32369257 |
Psoriasis | 93.28 | 12.98 | 12 | 94567 | 46111 | 32372836 |
Sweat gland tumour | 89.75 | 12.98 | 37 | 94542 | 391 | 32418556 |
Hallucination | 88.48 | 12.98 | 22 | 94557 | 52597 | 32366350 |
Cerebrovascular accident | 88.08 | 12.98 | 73 | 94506 | 86247 | 32332700 |
Aplasia | 86.19 | 12.98 | 84 | 94495 | 4358 | 32414589 |
Cytokine release syndrome | 84.77 | 12.98 | 146 | 94433 | 13389 | 32405558 |
Blood fibrinogen decreased | 83.96 | 12.98 | 47 | 94532 | 1017 | 32417930 |
Platelet count decreased | 83.45 | 12.98 | 595 | 93984 | 113996 | 32304951 |
Drug resistance | 82.94 | 12.98 | 197 | 94382 | 22768 | 32396179 |
Intentional product misuse | 81.76 | 12.98 | 6 | 94573 | 36045 | 32382902 |
Asthma | 81.07 | 12.98 | 15 | 94564 | 44050 | 32374897 |
Herpes simplex | 80.72 | 12.98 | 87 | 94492 | 5087 | 32413860 |
Cardiac failure congestive | 80.28 | 12.98 | 77 | 94502 | 84775 | 32334172 |
Ileus paralytic | 80.26 | 12.98 | 93 | 94486 | 5893 | 32413054 |
Nasopharyngitis | 79.79 | 12.98 | 43 | 94536 | 63744 | 32355203 |
Cytomegalovirus infection | 78.87 | 12.98 | 206 | 94373 | 25258 | 32393689 |
Drug interaction | 78.60 | 12.98 | 347 | 94232 | 217838 | 32201109 |
Diarrhoea | 77.10 | 12.98 | 685 | 93894 | 364117 | 32054830 |
Chronic obstructive pulmonary disease | 77.06 | 12.98 | 23 | 94556 | 48730 | 32370217 |
Infection | 76.94 | 12.98 | 465 | 94114 | 84250 | 32334697 |
Haemophagocytic lymphohistiocytosis | 75.94 | 12.98 | 126 | 94453 | 11209 | 32407738 |
Aggression | 75.56 | 12.98 | 12 | 94567 | 39377 | 32379570 |
Suicide attempt | 74.85 | 12.98 | 11 | 94568 | 38233 | 32380714 |
Blood glucose increased | 74.54 | 12.98 | 49 | 94530 | 65192 | 32353755 |
Chest pain | 74.40 | 12.98 | 156 | 94423 | 123981 | 32294966 |
Tremor | 74.31 | 12.98 | 76 | 94503 | 81201 | 32337746 |
Adenovirus infection | 73.21 | 12.98 | 79 | 94500 | 4625 | 32414322 |
Hyperhidrosis | 72.83 | 12.98 | 60 | 94519 | 71108 | 32347839 |
Blood culture positive | 72.07 | 12.98 | 81 | 94498 | 4964 | 32413983 |
Cerebral venous thrombosis | 71.92 | 12.98 | 36 | 94543 | 615 | 32418332 |
Fungal infection | 71.12 | 12.98 | 145 | 94434 | 15110 | 32403837 |
Multiple organ dysfunction syndrome | 70.95 | 12.98 | 395 | 94184 | 69459 | 32349488 |
Blood creatine phosphokinase increased | 70.88 | 12.98 | 22 | 94557 | 45454 | 32373493 |
Confusional state | 70.67 | 12.98 | 199 | 94380 | 142916 | 32276031 |
Colitis | 70.20 | 12.98 | 238 | 94341 | 33713 | 32385234 |
Blood pressure increased | 69.42 | 12.98 | 77 | 94502 | 79277 | 32339670 |
Enterovirus infection | 67.45 | 12.98 | 35 | 94544 | 647 | 32418300 |
Bronchopulmonary aspergillosis | 67.28 | 12.98 | 133 | 94446 | 13554 | 32405393 |
Lymphoma | 66.98 | 12.98 | 116 | 94463 | 10684 | 32408263 |
Neutropenic colitis | 65.99 | 12.98 | 57 | 94522 | 2528 | 32416419 |
Escherichia sepsis | 65.89 | 12.98 | 72 | 94507 | 4276 | 32414671 |
Hepatotoxicity | 64.62 | 12.98 | 161 | 94418 | 19176 | 32399771 |
Incorrect dose administered | 64.27 | 12.98 | 12 | 94567 | 35016 | 32383931 |
Oedema peripheral | 63.73 | 12.98 | 149 | 94430 | 113942 | 32305005 |
West Nile viral infection | 63.31 | 12.98 | 33 | 94546 | 616 | 32418331 |
Mucormycosis | 63.02 | 12.98 | 80 | 94499 | 5574 | 32413373 |
Agranulocytosis | 62.81 | 12.98 | 180 | 94399 | 23297 | 32395650 |
Memory impairment | 62.34 | 12.98 | 20 | 94559 | 40459 | 32378488 |
Bacterial sepsis | 62.19 | 12.98 | 77 | 94502 | 5231 | 32413716 |
Epstein-Barr virus associated lymphoproliferative disorder | 61.74 | 12.98 | 48 | 94531 | 1832 | 32417115 |
Systemic mycosis | 61.39 | 12.98 | 43 | 94536 | 1395 | 32417552 |
Injection site pain | 61.35 | 12.98 | 11 | 94568 | 33047 | 32385900 |
Superior sagittal sinus thrombosis | 61.35 | 12.98 | 26 | 94553 | 296 | 32418651 |
Chest discomfort | 59.75 | 12.98 | 36 | 94543 | 50194 | 32368753 |
Cytogenetic abnormality | 59.40 | 12.98 | 35 | 94544 | 837 | 32418110 |
Hypoglycaemia | 59.25 | 12.98 | 43 | 94536 | 54339 | 32364608 |
Asthenia | 58.98 | 12.98 | 423 | 94156 | 235521 | 32183426 |
Back pain | 58.90 | 12.98 | 149 | 94430 | 110904 | 32308043 |
Cerebral venous sinus thrombosis | 58.68 | 12.98 | 27 | 94552 | 379 | 32418568 |
Stem cell transplant | 58.67 | 12.98 | 50 | 94529 | 2177 | 32416770 |
Multiple-drug resistance | 58.05 | 12.98 | 63 | 94516 | 3712 | 32415235 |
Acute lymphocytic leukaemia refractory | 57.61 | 12.98 | 19 | 94560 | 99 | 32418848 |
Plasmablastic lymphoma | 57.60 | 12.98 | 25 | 94554 | 303 | 32418644 |
Minimal residual disease | 57.24 | 12.98 | 25 | 94554 | 308 | 32418639 |
Headache | 57.00 | 12.98 | 336 | 94243 | 195861 | 32223086 |
Adenoviral hepatitis | 56.91 | 12.98 | 23 | 94556 | 230 | 32418717 |
Stress | 56.79 | 12.98 | 3 | 94576 | 23779 | 32395168 |
Oesophageal stenosis | 56.60 | 12.98 | 44 | 94535 | 1679 | 32417268 |
Antithrombin III decreased | 56.13 | 12.98 | 26 | 94553 | 371 | 32418576 |
Pain in extremity | 56.01 | 12.98 | 169 | 94410 | 118732 | 32300215 |
JC virus infection | 55.57 | 12.98 | 46 | 94533 | 1923 | 32417024 |
Coombs positive haemolytic anaemia | 55.53 | 12.98 | 33 | 94546 | 802 | 32418145 |
Pseudomonas infection | 54.32 | 12.98 | 113 | 94466 | 11943 | 32407004 |
Gait disturbance | 54.31 | 12.98 | 94 | 94485 | 80314 | 32338633 |
Loss of personal independence in daily activities | 54.20 | 12.98 | 7 | 94572 | 26826 | 32392121 |
Pleural effusion | 53.92 | 12.98 | 404 | 94175 | 78588 | 32340359 |
Pneumonitis | 53.53 | 12.98 | 201 | 94378 | 29933 | 32389014 |
Malignant transformation | 53.37 | 12.98 | 32 | 94547 | 791 | 32418156 |
Gastritis bacterial | 53.23 | 12.98 | 21 | 94558 | 196 | 32418751 |
Staphylococcal sepsis | 53.22 | 12.98 | 100 | 94479 | 9813 | 32409134 |
Musculoskeletal stiffness | 52.82 | 12.98 | 24 | 94555 | 39240 | 32379707 |
Strongyloidiasis | 52.65 | 12.98 | 50 | 94529 | 2511 | 32416436 |
Anaemia | 52.26 | 12.98 | 927 | 93652 | 222697 | 32196250 |
Leukaemia recurrent | 52.00 | 12.98 | 41 | 94538 | 1598 | 32417349 |
Drug hypersensitivity | 51.24 | 12.98 | 84 | 94495 | 73316 | 32345631 |
Wrong technique in product usage process | 51.09 | 12.98 | 19 | 94560 | 35040 | 32383907 |
Respiratory failure | 51.00 | 12.98 | 506 | 94073 | 106676 | 32312271 |
Arthropathy | 50.26 | 12.98 | 4 | 94575 | 22485 | 32396462 |
Inappropriate antidiuretic hormone secretion | 49.66 | 12.98 | 109 | 94470 | 11954 | 32406993 |
Aspiration bone marrow abnormal | 49.55 | 12.98 | 17 | 94562 | 102 | 32418845 |
Glioma | 49.17 | 12.98 | 23 | 94556 | 336 | 32418611 |
Infection reactivation | 48.00 | 12.98 | 34 | 94545 | 1123 | 32417824 |
Device related infection | 47.49 | 12.98 | 137 | 94442 | 17796 | 32401151 |
Balance disorder | 47.32 | 12.98 | 28 | 94551 | 39431 | 32379516 |
Cystitis haemorrhagic | 47.22 | 12.98 | 66 | 94513 | 5048 | 32413899 |
Abdominal discomfort | 47.19 | 12.98 | 50 | 94529 | 52574 | 32366373 |
Syncope | 46.94 | 12.98 | 122 | 94457 | 90002 | 32328945 |
Epstein-Barr virus associated lymphoma | 46.88 | 12.98 | 27 | 94552 | 618 | 32418329 |
Myelitis transverse | 46.21 | 12.98 | 32 | 94547 | 1019 | 32417928 |
Wheezing | 45.89 | 12.98 | 25 | 94554 | 36849 | 32382098 |
Hepatosplenic candidiasis | 45.57 | 12.98 | 19 | 94560 | 207 | 32418740 |
Escherichia bacteraemia | 45.21 | 12.98 | 51 | 94528 | 3138 | 32415809 |
Peripheral motor neuropathy | 45.20 | 12.98 | 39 | 94540 | 1727 | 32417220 |
Hyperkalaemia | 44.89 | 12.98 | 84 | 94495 | 69666 | 32349281 |
Viral haemorrhagic cystitis | 44.74 | 12.98 | 30 | 94549 | 905 | 32418042 |
Bone marrow necrosis | 44.74 | 12.98 | 17 | 94562 | 142 | 32418805 |
Coagulopathy | 44.73 | 12.98 | 142 | 94437 | 19435 | 32399512 |
Intussusception | 44.45 | 12.98 | 25 | 94554 | 546 | 32418401 |
Peripheral T-cell lymphoma unspecified | 44.21 | 12.98 | 25 | 94554 | 552 | 32418395 |
Hepatomegaly | 43.63 | 12.98 | 95 | 94484 | 10362 | 32408585 |
Central nervous system leukaemia | 43.51 | 12.98 | 20 | 94559 | 280 | 32418667 |
Sleep disorder | 43.41 | 12.98 | 12 | 94567 | 26740 | 32392207 |
Disseminated intravascular coagulation | 43.18 | 12.98 | 157 | 94422 | 23019 | 32395928 |
Loss of consciousness | 43.04 | 12.98 | 112 | 94467 | 82595 | 32336352 |
Nausea | 42.95 | 12.98 | 666 | 93913 | 320183 | 32098764 |
Unevaluable event | 42.93 | 12.98 | 22 | 94557 | 33564 | 32385383 |
Lymphadenitis | 42.29 | 12.98 | 38 | 94541 | 1777 | 32417170 |
Sedation | 42.24 | 12.98 | 3 | 94576 | 18523 | 32400424 |
Injury | 42.16 | 12.98 | 7 | 94572 | 22238 | 32396709 |
Mobility decreased | 42.07 | 12.98 | 15 | 94564 | 28394 | 32390553 |
Gastrointestinal toxicity | 42.05 | 12.98 | 41 | 94538 | 2128 | 32416819 |
Klebsiella infection | 41.99 | 12.98 | 80 | 94499 | 7932 | 32411015 |
Therapy non-responder | 41.75 | 12.98 | 197 | 94382 | 32457 | 32386490 |
Product quality issue | 41.41 | 12.98 | 4 | 94575 | 19229 | 32399718 |
Recurrent cancer | 41.37 | 12.98 | 32 | 94547 | 1212 | 32417735 |
Cardiomyopathy | 41.12 | 12.98 | 121 | 94458 | 15892 | 32403055 |
Serotonin syndrome | 41.10 | 12.98 | 4 | 94575 | 19113 | 32399834 |
Treatment noncompliance | 40.90 | 12.98 | 14 | 94565 | 27188 | 32391759 |
Weight decreased | 40.87 | 12.98 | 296 | 94283 | 164522 | 32254425 |
Lung infiltration | 40.85 | 12.98 | 106 | 94473 | 12942 | 32406005 |
End stage renal disease | 40.59 | 12.98 | 79 | 94500 | 7958 | 32410989 |
Refractory anaemia with an excess of blasts | 39.63 | 12.98 | 21 | 94558 | 406 | 32418541 |
Nephrolithiasis | 39.56 | 12.98 | 15 | 94564 | 27339 | 32391608 |
Neuroleptic malignant syndrome | 39.41 | 12.98 | 3 | 94576 | 17492 | 32401455 |
Escherichia infection | 39.40 | 12.98 | 73 | 94506 | 7087 | 32411860 |
Lymphoma transformation | 39.33 | 12.98 | 16 | 94563 | 163 | 32418784 |
Pneumonia aspiration | 39.31 | 12.98 | 37 | 94542 | 41119 | 32377828 |
Systemic candida | 38.94 | 12.98 | 46 | 94533 | 2975 | 32415972 |
Blood pressure fluctuation | 38.92 | 12.98 | 6 | 94573 | 20129 | 32398818 |
Central nervous system neoplasm | 38.61 | 12.98 | 13 | 94566 | 73 | 32418874 |
Primitive neuroectodermal tumour | 38.61 | 12.98 | 13 | 94566 | 73 | 32418874 |
Contusion | 38.40 | 12.98 | 25 | 94554 | 33443 | 32385504 |
Encephalopathy | 38.34 | 12.98 | 199 | 94380 | 34058 | 32384889 |
Respiratory distress | 38.25 | 12.98 | 203 | 94376 | 35043 | 32383904 |
Congenital cardiovascular anomaly | 37.69 | 12.98 | 16 | 94563 | 183 | 32418764 |
Drug reaction with eosinophilia and systemic symptoms | 37.63 | 12.98 | 24 | 94555 | 32461 | 32386486 |
Dry skin | 37.31 | 12.98 | 13 | 94566 | 24965 | 32393982 |
International normalised ratio increased | 37.21 | 12.98 | 53 | 94526 | 48982 | 32369965 |
Encephalitis enteroviral | 37.20 | 12.98 | 15 | 94564 | 149 | 32418798 |
Pulmonary vascular disorder | 37.02 | 12.98 | 23 | 94556 | 607 | 32418340 |
Optic glioma | 36.73 | 12.98 | 11 | 94568 | 39 | 32418908 |
Adverse event | 36.61 | 12.98 | 3 | 94576 | 16469 | 32402478 |
Haemolysis | 36.57 | 12.98 | 74 | 94505 | 7667 | 32411280 |
Atrial fibrillation | 36.48 | 12.98 | 195 | 94384 | 116509 | 32302438 |
Depressed mood | 36.42 | 12.98 | 5 | 94574 | 18295 | 32400652 |
B-cell lymphoma refractory | 36.03 | 12.98 | 14 | 94565 | 125 | 32418822 |
Pneumocystis jirovecii infection | 35.98 | 12.98 | 32 | 94547 | 1476 | 32417471 |
Abdominal pain upper | 35.95 | 12.98 | 90 | 94489 | 67248 | 32351699 |
Hepatosplenomegaly | 35.49 | 12.98 | 50 | 94529 | 3853 | 32415094 |
Bone marrow disorder | 35.29 | 12.98 | 33 | 94546 | 1625 | 32417322 |
Juvenile melanoma benign | 35.26 | 12.98 | 12 | 94567 | 70 | 32418877 |
Chronic lymphocytic leukaemia refractory | 35.14 | 12.98 | 13 | 94566 | 100 | 32418847 |
Pulmonary arteriopathy | 34.97 | 12.98 | 12 | 94567 | 72 | 32418875 |
Ejection fraction decreased | 34.93 | 12.98 | 122 | 94457 | 17536 | 32401411 |
Bradycardia | 34.91 | 12.98 | 100 | 94479 | 71462 | 32347485 |
T-cell type acute leukaemia | 34.84 | 12.98 | 15 | 94564 | 178 | 32418769 |
Heart rate decreased | 34.52 | 12.98 | 15 | 94564 | 25185 | 32393762 |
Fluid retention | 34.52 | 12.98 | 17 | 94562 | 26533 | 32392414 |
Acute myelomonocytic leukaemia | 34.46 | 12.98 | 14 | 94565 | 142 | 32418805 |
Abnormal behaviour | 34.33 | 12.98 | 17 | 94562 | 26449 | 32392498 |
Haematochezia | 34.32 | 12.98 | 38 | 94541 | 39170 | 32379777 |
Blood stem cell transplant failure | 34.19 | 12.98 | 19 | 94560 | 405 | 32418542 |
Peripheral sensory neuropathy | 34.08 | 12.98 | 65 | 94514 | 6449 | 32412498 |
Intestinal perforation | 34.08 | 12.98 | 78 | 94501 | 8797 | 32410150 |
Retinal haemorrhage | 33.88 | 12.98 | 56 | 94523 | 4965 | 32413982 |
Cardio-respiratory arrest | 33.80 | 12.98 | 70 | 94509 | 55919 | 32363028 |
Staphylococcal bacteraemia | 33.59 | 12.98 | 70 | 94509 | 7406 | 32411541 |
Body height below normal | 33.59 | 12.98 | 16 | 94563 | 244 | 32418703 |
T-cell lymphoma | 33.36 | 12.98 | 26 | 94553 | 996 | 32417951 |
Haemoglobin abnormal | 33.03 | 12.98 | 45 | 94534 | 3360 | 32415587 |
Electrocardiogram QT prolonged | 32.99 | 12.98 | 40 | 94539 | 39601 | 32379346 |
Adverse drug reaction | 32.96 | 12.98 | 17 | 94562 | 25844 | 32393103 |
Influenza | 32.72 | 12.98 | 52 | 94527 | 45962 | 32372985 |
Rhabdomyosarcoma recurrent | 32.70 | 12.98 | 12 | 94567 | 90 | 32418857 |
Hypersensitivity | 32.57 | 12.98 | 75 | 94504 | 57683 | 32361264 |
Xanthogranuloma | 32.45 | 12.98 | 10 | 94569 | 40 | 32418907 |
Bacterial infection | 32.37 | 12.98 | 102 | 94477 | 13904 | 32405043 |
Nervous system disorder | 32.18 | 12.98 | 102 | 94477 | 13947 | 32405000 |
Neuroblastoma | 32.13 | 12.98 | 15 | 94564 | 218 | 32418729 |
Pneumonia fungal | 32.04 | 12.98 | 62 | 94517 | 6218 | 32412729 |
Gene mutation | 32.00 | 12.98 | 25 | 94554 | 961 | 32417986 |
Pulmonary toxicity | 31.76 | 12.98 | 54 | 94525 | 4899 | 32414048 |
Injection site erythema | 31.71 | 12.98 | 3 | 94576 | 14665 | 32404282 |
Blood creatinine increased | 31.52 | 12.98 | 158 | 94421 | 95974 | 32322973 |
Hereditary motor and sensory neuropathy | 31.45 | 12.98 | 8 | 94571 | 12 | 32418935 |
Palpitations | 31.33 | 12.98 | 35 | 94544 | 35934 | 32383013 |
Ganglioneuroblastoma | 31.19 | 12.98 | 9 | 94570 | 27 | 32418920 |
Gastrooesophageal reflux disease | 31.14 | 12.98 | 33 | 94546 | 34705 | 32384242 |
Acute promyelocytic leukaemia | 30.83 | 12.98 | 20 | 94559 | 570 | 32418377 |
Acute monocytic leukaemia | 30.69 | 12.98 | 17 | 94562 | 360 | 32418587 |
B-cell type acute leukaemia | 30.30 | 12.98 | 16 | 94563 | 307 | 32418640 |
Autoimmune lymphoproliferative syndrome | 30.22 | 12.98 | 13 | 94566 | 154 | 32418793 |
Agitation | 30.16 | 12.98 | 77 | 94502 | 57159 | 32361788 |
Cardiac disorder | 30.07 | 12.98 | 47 | 94532 | 41819 | 32377128 |
Plasma cell myeloma | 29.98 | 12.98 | 78 | 94501 | 57536 | 32361411 |
Mass | 29.97 | 12.98 | 68 | 94511 | 7624 | 32411323 |
Astrocytoma | 29.90 | 12.98 | 14 | 94565 | 205 | 32418742 |
Transformation to acute myeloid leukaemia | 29.88 | 12.98 | 21 | 94558 | 685 | 32418262 |
Amnesia | 29.68 | 12.98 | 18 | 94561 | 25018 | 32393929 |
Sleep apnoea syndrome | 29.49 | 12.98 | 9 | 94570 | 18805 | 32400142 |
Hot flush | 29.48 | 12.98 | 5 | 94574 | 15641 | 32403306 |
Subdural hygroma | 29.44 | 12.98 | 16 | 94563 | 326 | 32418621 |
Pseudomonal sepsis | 29.33 | 12.98 | 40 | 94539 | 2989 | 32415958 |
Varicella zoster virus infection | 29.32 | 12.98 | 29 | 94550 | 1532 | 32417415 |
Human rhinovirus test positive | 29.14 | 12.98 | 13 | 94566 | 169 | 32418778 |
Musculoskeletal pain | 28.93 | 12.98 | 30 | 94549 | 31867 | 32387080 |
Neurofibrosarcoma | 28.82 | 12.98 | 9 | 94570 | 38 | 32418909 |
Epstein-Barr viraemia | 28.77 | 12.98 | 24 | 94555 | 1014 | 32417933 |
Transient ischaemic attack | 28.61 | 12.98 | 20 | 94559 | 25774 | 32393173 |
Hepatic infection fungal | 28.35 | 12.98 | 13 | 94566 | 181 | 32418766 |
Anal inflammation | 28.22 | 12.98 | 16 | 94563 | 355 | 32418592 |
Bone marrow infiltration | 28.04 | 12.98 | 11 | 94568 | 101 | 32418846 |
Delayed puberty | 27.97 | 12.98 | 13 | 94566 | 187 | 32418760 |
Blood pressure systolic increased | 27.86 | 12.98 | 8 | 94571 | 17388 | 32401559 |
Clostridium test positive | 27.77 | 12.98 | 34 | 94545 | 2283 | 32416664 |
Prostatic specific antigen increased | 27.72 | 12.98 | 3 | 94576 | 13184 | 32405763 |
Chronic kidney disease | 27.65 | 12.98 | 46 | 94533 | 39929 | 32379018 |
Small intestinal perforation | 27.62 | 12.98 | 30 | 94549 | 1769 | 32417178 |
Pneumonia viral | 27.33 | 12.98 | 38 | 94541 | 2892 | 32416055 |
Psoriatic arthropathy | 27.19 | 12.98 | 9 | 94570 | 17851 | 32401096 |
BK virus infection | 27.15 | 12.98 | 50 | 94529 | 4831 | 32414116 |
Chronic lymphocytic leukaemia | 27.12 | 12.98 | 50 | 94529 | 4835 | 32414112 |
Mantle cell lymphoma | 27.06 | 12.98 | 29 | 94550 | 1684 | 32417263 |
Myocardial ischaemia | 26.94 | 12.98 | 9 | 94570 | 17750 | 32401197 |
Gallbladder oedema | 26.90 | 12.98 | 13 | 94566 | 205 | 32418742 |
Acute hepatic failure | 26.87 | 12.98 | 91 | 94488 | 12878 | 32406069 |
Ewing's sarcoma | 26.79 | 12.98 | 8 | 94571 | 28 | 32418919 |
Dysgeusia | 26.76 | 12.98 | 21 | 94558 | 25510 | 32393437 |
Gastrosplenic fistula | 26.58 | 12.98 | 8 | 94571 | 29 | 32418918 |
Influenza like illness | 26.39 | 12.98 | 24 | 94555 | 27116 | 32391831 |
High-grade B-cell lymphoma | 26.37 | 12.98 | 12 | 94567 | 164 | 32418783 |
Therapy cessation | 26.32 | 12.98 | 7 | 94572 | 16006 | 32402941 |
Enterococcal infection | 26.29 | 12.98 | 72 | 94507 | 9075 | 32409872 |
Traumatic lung injury | 26.23 | 12.98 | 25 | 94554 | 1261 | 32417686 |
Hepatic candidiasis | 26.23 | 12.98 | 9 | 94570 | 54 | 32418893 |
Blood glucose decreased | 26.23 | 12.98 | 4 | 94575 | 13530 | 32405417 |
Hepatocellular injury | 26.23 | 12.98 | 144 | 94435 | 25174 | 32393773 |
Cerebral thrombosis | 26.16 | 12.98 | 22 | 94557 | 940 | 32418007 |
Rash pruritic | 26.10 | 12.98 | 20 | 94559 | 24591 | 32394356 |
Vision blurred | 26.03 | 12.98 | 56 | 94523 | 44130 | 32374817 |
Decreased appetite | 26.02 | 12.98 | 321 | 94258 | 160492 | 32258455 |
Glioblastoma multiforme | 26.01 | 12.98 | 21 | 94558 | 847 | 32418100 |
Dyspepsia | 25.80 | 12.98 | 35 | 94544 | 33020 | 32385927 |
Clostridium difficile colitis | 25.78 | 12.98 | 96 | 94483 | 14235 | 32404712 |
Labelled drug-drug interaction medication error | 25.65 | 12.98 | 3 | 94576 | 12410 | 32406537 |
Oesophageal candidiasis | 25.55 | 12.98 | 46 | 94533 | 4368 | 32414579 |
Diffuse large B-cell lymphoma stage III | 25.43 | 12.98 | 9 | 94570 | 60 | 32418887 |
Vertigo | 25.41 | 12.98 | 20 | 94559 | 24263 | 32394684 |
Erectile dysfunction | 25.34 | 12.98 | 13 | 94566 | 19826 | 32399121 |
Psychotic disorder | 25.33 | 12.98 | 18 | 94561 | 23002 | 32395945 |
Drug clearance decreased | 25.28 | 12.98 | 26 | 94553 | 1439 | 32417508 |
Lymphocytosis | 25.26 | 12.98 | 31 | 94548 | 2086 | 32416861 |
Cellulitis gangrenous | 25.19 | 12.98 | 12 | 94567 | 183 | 32418764 |
Splenic lesion | 25.08 | 12.98 | 11 | 94568 | 137 | 32418810 |
Rhabdomyosarcoma | 25.06 | 12.98 | 9 | 94570 | 63 | 32418884 |
Transaminases increased | 25.03 | 12.98 | 141 | 94438 | 24887 | 32394060 |
Delirium | 24.99 | 12.98 | 57 | 94522 | 43989 | 32374958 |
Rib fracture | 24.96 | 12.98 | 5 | 94574 | 13884 | 32405063 |
Withdrawal syndrome | 24.88 | 12.98 | 3 | 94576 | 12119 | 32406828 |
Ascites | 24.87 | 12.98 | 201 | 94378 | 39990 | 32378957 |
Herpes simplex encephalitis | 24.72 | 12.98 | 14 | 94565 | 310 | 32418637 |
Thymus enlargement | 24.70 | 12.98 | 9 | 94570 | 66 | 32418881 |
Clostridium difficile infection | 24.70 | 12.98 | 110 | 94469 | 17686 | 32401261 |
Left ventricular dysfunction | 24.64 | 12.98 | 73 | 94506 | 9622 | 32409325 |
Burning sensation | 24.59 | 12.98 | 10 | 94569 | 17468 | 32401479 |
Cytomegalovirus infection reactivation | 24.58 | 12.98 | 39 | 94540 | 3340 | 32415607 |
Interstitial lung disease | 24.47 | 12.98 | 293 | 94286 | 64708 | 32354239 |
Medulloblastoma recurrent | 24.47 | 12.98 | 9 | 94570 | 68 | 32418879 |
Renal impairment | 24.33 | 12.98 | 162 | 94417 | 91810 | 32327137 |
Pneumatosis intestinalis | 24.23 | 12.98 | 39 | 94540 | 3381 | 32415566 |
Restlessness | 24.19 | 12.98 | 22 | 94557 | 24859 | 32394088 |
Alanine aminotransferase increased | 24.19 | 12.98 | 341 | 94238 | 78138 | 32340809 |
Splenic marginal zone lymphoma | 24.05 | 12.98 | 8 | 94571 | 43 | 32418904 |
Intestinal atresia | 24.02 | 12.98 | 9 | 94570 | 72 | 32418875 |
Angioedema | 23.96 | 12.98 | 43 | 94536 | 36246 | 32382701 |
Toxicity to various agents | 23.93 | 12.98 | 369 | 94210 | 177672 | 32241275 |
Gastrointestinal necrosis | 23.90 | 12.98 | 39 | 94540 | 3420 | 32415527 |
Device related thrombosis | 23.90 | 12.98 | 21 | 94558 | 953 | 32417994 |
Hallucination, visual | 23.85 | 12.98 | 10 | 94569 | 17149 | 32401798 |
Eczema | 23.78 | 12.98 | 7 | 94572 | 14973 | 32403974 |
Liver function test abnormal | 23.77 | 12.98 | 35 | 94544 | 31912 | 32387035 |
Erythema | 23.72 | 12.98 | 143 | 94436 | 82962 | 32335985 |
Faeces discoloured | 23.53 | 12.98 | 7 | 94572 | 14870 | 32404077 |
Peritonitis bacterial | 23.53 | 12.98 | 4 | 94575 | 12492 | 32406455 |
Azoospermia | 23.52 | 12.98 | 15 | 94564 | 415 | 32418532 |
Haemorrhage | 23.45 | 12.98 | 70 | 94509 | 49378 | 32369569 |
Rhinovirus infection | 23.27 | 12.98 | 38 | 94541 | 3335 | 32415612 |
Flushing | 23.26 | 12.98 | 34 | 94545 | 31093 | 32387854 |
Blood lactate dehydrogenase increased | 23.25 | 12.98 | 125 | 94454 | 21680 | 32397267 |
Metastases to bone marrow | 23.23 | 12.98 | 16 | 94563 | 505 | 32418442 |
Arthritis | 23.21 | 12.98 | 26 | 94553 | 26666 | 32392281 |
Intestinal pseudo-obstruction | 23.21 | 12.98 | 24 | 94555 | 1337 | 32417610 |
Delusion | 22.98 | 12.98 | 5 | 94574 | 13103 | 32405844 |
Facial paresis | 22.96 | 12.98 | 35 | 94544 | 2896 | 32416051 |
Cardiac arrest | 22.91 | 12.98 | 176 | 94403 | 96600 | 32322347 |
Chronic myeloid leukaemia | 22.88 | 12.98 | 34 | 94545 | 2750 | 32416197 |
Diffuse large B-cell lymphoma stage IV | 22.79 | 12.98 | 13 | 94566 | 292 | 32418655 |
Enterocolitis infectious | 22.79 | 12.98 | 23 | 94556 | 1245 | 32417702 |
Congenital herpes simplex infection | 22.78 | 12.98 | 8 | 94571 | 52 | 32418895 |
Pseudomonal bacteraemia | 22.77 | 12.98 | 21 | 94558 | 1016 | 32417931 |
Ameloblastoma | 22.72 | 12.98 | 9 | 94570 | 85 | 32418862 |
Loss of CAR T-cell persistence | 22.72 | 12.98 | 7 | 94572 | 28 | 32418919 |
Pseudomonas test positive | 22.68 | 12.98 | 21 | 94558 | 1021 | 32417926 |
Cerebral salt-wasting syndrome | 22.65 | 12.98 | 8 | 94571 | 53 | 32418894 |
Refractory cancer | 22.63 | 12.98 | 10 | 94569 | 127 | 32418820 |
Localised infection | 22.51 | 12.98 | 8 | 94571 | 15179 | 32403768 |
Skin exfoliation | 22.44 | 12.98 | 24 | 94555 | 25133 | 32393814 |
Rectal haemorrhage | 22.40 | 12.98 | 47 | 94532 | 37376 | 32381571 |
Lower respiratory tract infection fungal | 22.39 | 12.98 | 17 | 94562 | 626 | 32418321 |
Positron emission tomogram abnormal | 22.35 | 12.98 | 10 | 94569 | 131 | 32418816 |
Cerebral aspergillosis | 22.25 | 12.98 | 24 | 94555 | 1404 | 32417543 |
Hepatitis | 22.07 | 12.98 | 131 | 94448 | 23562 | 32395385 |
Escherichia test positive | 22.02 | 12.98 | 22 | 94557 | 1176 | 32417771 |
Mucosal infection | 22.01 | 12.98 | 12 | 94567 | 246 | 32418701 |
Gastrointestinal haemorrhage | 22.00 | 12.98 | 155 | 94424 | 86727 | 32332220 |
Anger | 22.00 | 12.98 | 4 | 94575 | 11900 | 32407047 |
Disturbance in attention | 21.93 | 12.98 | 22 | 94557 | 23731 | 32395216 |
Pneumoperitoneum | 21.63 | 12.98 | 27 | 94552 | 1849 | 32417098 |
Genotoxicity | 21.63 | 12.98 | 7 | 94572 | 34 | 32418913 |
Paraplegia | 21.62 | 12.98 | 33 | 94546 | 2733 | 32416214 |
Renal salt-wasting syndrome | 21.44 | 12.98 | 10 | 94569 | 145 | 32418802 |
Stomatococcal infection | 21.44 | 12.98 | 10 | 94569 | 145 | 32418802 |
Blastic plasmacytoid dendritic cell neoplasia | 21.43 | 12.98 | 9 | 94570 | 100 | 32418847 |
Orthostatic hypotension | 21.22 | 12.98 | 26 | 94553 | 25624 | 32393323 |
Acute lung injury | 21.19 | 12.98 | 23 | 94556 | 1355 | 32417592 |
Molluscum contagiosum | 21.18 | 12.98 | 12 | 94567 | 266 | 32418681 |
Central nervous system fungal infection | 21.10 | 12.98 | 13 | 94566 | 338 | 32418609 |
Bronchitis | 20.98 | 12.98 | 57 | 94522 | 41450 | 32377497 |
Granulocyte count decreased | 20.94 | 12.98 | 17 | 94562 | 691 | 32418256 |
Focal nodular hyperplasia | 20.90 | 12.98 | 10 | 94569 | 154 | 32418793 |
Disorientation | 20.84 | 12.98 | 41 | 94538 | 33384 | 32385563 |
Hepatitis viral | 20.71 | 12.98 | 16 | 94563 | 605 | 32418342 |
Ileus | 20.69 | 12.98 | 98 | 94481 | 16167 | 32402780 |
Administration site extravasation | 20.65 | 12.98 | 15 | 94564 | 516 | 32418431 |
Salivary gland cancer | 20.63 | 12.98 | 12 | 94567 | 280 | 32418667 |
Blindness cortical | 20.60 | 12.98 | 13 | 94566 | 353 | 32418594 |
Vocal cord paralysis | 20.47 | 12.98 | 19 | 94560 | 927 | 32418020 |
Hepatic amoebiasis | 20.44 | 12.98 | 8 | 94571 | 73 | 32418874 |
Personality change due to a general medical condition | 20.40 | 12.98 | 7 | 94572 | 42 | 32418905 |
Metastases to spleen | 20.40 | 12.98 | 13 | 94566 | 359 | 32418588 |
Cerebral toxoplasmosis | 20.37 | 12.98 | 24 | 94555 | 1548 | 32417399 |
Metastases to retroperitoneum | 20.29 | 12.98 | 11 | 94568 | 223 | 32418724 |
Hepatitis D | 20.26 | 12.98 | 7 | 94572 | 43 | 32418904 |
Respiratory arrest | 20.24 | 12.98 | 33 | 94546 | 28875 | 32390072 |
Accidental exposure to product | 20.20 | 12.98 | 4 | 94575 | 11198 | 32407749 |
Acute erythroid leukaemia | 20.18 | 12.98 | 10 | 94569 | 167 | 32418780 |
Non-Hodgkin's lymphoma | 20.11 | 12.98 | 25 | 94554 | 1705 | 32417242 |
Dermatitis diaper | 20.11 | 12.98 | 12 | 94567 | 294 | 32418653 |
Stevens-Johnson syndrome | 20.10 | 12.98 | 15 | 94564 | 18694 | 32400253 |
Hypersomnia | 20.10 | 12.98 | 5 | 94574 | 11956 | 32406991 |
Haematopoietic stem cell mobilisation | 20.07 | 12.98 | 10 | 94569 | 169 | 32418778 |
Vascular access complication | 20.07 | 12.98 | 11 | 94568 | 228 | 32418719 |
Sphingomonas paucimobilis infection | 19.99 | 12.98 | 7 | 94572 | 45 | 32418902 |
Respiratory tract infection fungal | 19.97 | 12.98 | 17 | 94562 | 739 | 32418208 |
Immunosuppression | 19.96 | 12.98 | 48 | 94531 | 5589 | 32413358 |
Platelet transfusion | 19.95 | 12.98 | 20 | 94559 | 1074 | 32417873 |
Suspected product quality issue | 19.92 | 12.98 | 10 | 94569 | 172 | 32418775 |
Retinopathy proliferative | 19.88 | 12.98 | 8 | 94571 | 79 | 32418868 |
Parainfluenzae virus infection | 19.87 | 12.98 | 29 | 94550 | 2308 | 32416639 |
Morphoea | 19.86 | 12.98 | 10 | 94569 | 173 | 32418774 |
Arteriosclerosis | 19.77 | 12.98 | 4 | 94575 | 11030 | 32407917 |
Extravasation | 19.76 | 12.98 | 26 | 94553 | 1877 | 32417070 |
Diabetic ketoacidosis | 19.76 | 12.98 | 14 | 94565 | 17918 | 32401029 |
Periorbital infection | 19.71 | 12.98 | 9 | 94570 | 124 | 32418823 |
Limb injury | 19.69 | 12.98 | 3 | 94576 | 10156 | 32408791 |
Limb discomfort | 19.68 | 12.98 | 3 | 94576 | 10151 | 32408796 |
Osteosarcoma | 19.65 | 12.98 | 11 | 94568 | 238 | 32418709 |
Sopor | 19.57 | 12.98 | 5 | 94574 | 11744 | 32407203 |
Burkitt's lymphoma | 19.56 | 12.98 | 10 | 94569 | 179 | 32418768 |
Lymphoplasmacytoid lymphoma/immunocytoma | 19.49 | 12.98 | 7 | 94572 | 49 | 32418898 |
Lactic acidosis | 19.34 | 12.98 | 43 | 94536 | 33493 | 32385454 |
Head injury | 19.19 | 12.98 | 14 | 94565 | 17649 | 32401298 |
Pulmonary veno-occlusive disease | 19.18 | 12.98 | 14 | 94565 | 485 | 32418462 |
Diabetes mellitus inadequate control | 19.17 | 12.98 | 8 | 94571 | 13760 | 32405187 |
Microgenia | 19.09 | 12.98 | 5 | 94574 | 9 | 32418938 |
Disseminated cryptococcosis | 19.05 | 12.98 | 20 | 94559 | 1134 | 32417813 |
Epidermal necrosis | 19.03 | 12.98 | 14 | 94565 | 491 | 32418456 |
Neutropenic infection | 19.03 | 12.98 | 21 | 94558 | 1261 | 32417686 |
Diffuse large B-cell lymphoma stage II | 19.02 | 12.98 | 7 | 94572 | 53 | 32418894 |
Stomatitis necrotising | 18.96 | 12.98 | 8 | 94571 | 90 | 32418857 |
Chloroma | 18.84 | 12.98 | 14 | 94565 | 499 | 32418448 |
Bone sarcoma | 18.81 | 12.98 | 8 | 94571 | 92 | 32418855 |
Hyperpyrexia | 18.80 | 12.98 | 31 | 94548 | 2743 | 32416204 |
Vagus nerve paralysis | 18.75 | 12.98 | 5 | 94574 | 10 | 32418937 |
Diabetes mellitus | 18.63 | 12.98 | 68 | 94511 | 45105 | 32373842 |
Drug eruption | 18.57 | 12.98 | 17 | 94562 | 19149 | 32399798 |
Granulocytopenia neonatal | 18.56 | 12.98 | 6 | 94573 | 29 | 32418918 |
Marginal zone lymphoma recurrent | 18.56 | 12.98 | 6 | 94573 | 29 | 32418918 |
Pneumonia cytomegaloviral | 18.53 | 12.98 | 32 | 94547 | 2940 | 32416007 |
Iron deficiency anaemia | 18.50 | 12.98 | 3 | 94576 | 9698 | 32409249 |
Condition aggravated | 18.48 | 12.98 | 330 | 94249 | 155331 | 32263616 |
Anaplastic large-cell lymphoma | 18.43 | 12.98 | 10 | 94569 | 203 | 32418744 |
Basal cell naevus syndrome | 18.39 | 12.98 | 6 | 94573 | 30 | 32418917 |
Bacillus test positive | 18.39 | 12.98 | 6 | 94573 | 30 | 32418917 |
Streptococcal infection | 18.38 | 12.98 | 43 | 94536 | 4919 | 32414028 |
Blood bilirubin increased | 18.36 | 12.98 | 183 | 94396 | 38601 | 32380346 |
Dry mouth | 18.36 | 12.98 | 26 | 94553 | 24093 | 32394854 |
Lung opacity | 18.31 | 12.98 | 22 | 94557 | 1448 | 32417499 |
Plasma cell myeloma refractory | 18.26 | 12.98 | 7 | 94572 | 60 | 32418887 |
Abdominal neoplasm | 18.26 | 12.98 | 10 | 94569 | 207 | 32418740 |
Phlebitis infective | 18.23 | 12.98 | 9 | 94570 | 149 | 32418798 |
Injection site swelling | 18.20 | 12.98 | 3 | 94576 | 9581 | 32409366 |
Gastrointestinal inflammation | 18.19 | 12.98 | 33 | 94546 | 3151 | 32415796 |
Muscle rigidity | 18.18 | 12.98 | 5 | 94574 | 11181 | 32407766 |
Renal tubular disorder | 18.10 | 12.98 | 44 | 94535 | 5158 | 32413789 |
Dehydration | 18.10 | 12.98 | 265 | 94314 | 128693 | 32290254 |
Extrapyramidal disorder | 18.09 | 12.98 | 6 | 94573 | 11889 | 32407058 |
Metastases to muscle | 18.09 | 12.98 | 10 | 94569 | 211 | 32418736 |
Humoral immune defect | 18.06 | 12.98 | 7 | 94572 | 62 | 32418885 |
Pancreatitis | 18.06 | 12.98 | 180 | 94399 | 37971 | 32380976 |
Urinary retention | 18.06 | 12.98 | 49 | 94530 | 35648 | 32383299 |
Hallucination, auditory | 18.04 | 12.98 | 4 | 94575 | 10346 | 32408601 |
Prescribed overdose | 18.03 | 12.98 | 3 | 94576 | 9516 | 32409431 |
Secondary immunodeficiency | 17.96 | 12.98 | 12 | 94567 | 360 | 32418587 |
Candida sepsis | 17.88 | 12.98 | 20 | 94559 | 1219 | 32417728 |
Urticaria | 17.84 | 12.98 | 101 | 94478 | 59513 | 32359434 |
Acute kidney injury | 17.82 | 12.98 | 686 | 93893 | 292782 | 32126165 |
Candida endophthalmitis | 17.80 | 12.98 | 8 | 94571 | 106 | 32418841 |
Metapneumovirus infection | 17.76 | 12.98 | 15 | 94564 | 645 | 32418302 |
Body temperature decreased | 17.76 | 12.98 | 5 | 94574 | 11009 | 32407938 |
Pulmonary sarcoidosis | 17.64 | 12.98 | 14 | 94565 | 551 | 32418396 |
Obesity | 17.61 | 12.98 | 4 | 94575 | 10178 | 32408769 |
Leukaemia | 17.53 | 12.98 | 37 | 94542 | 3949 | 32414998 |
Swelling | 17.49 | 12.98 | 55 | 94524 | 38167 | 32380780 |
Gastric stenosis | 17.49 | 12.98 | 6 | 94573 | 36 | 32418911 |
Infusion site discolouration | 17.47 | 12.98 | 8 | 94571 | 111 | 32418836 |
Lymphocytic leukaemia | 17.46 | 12.98 | 9 | 94570 | 164 | 32418783 |
Enterovesical fistula | 17.41 | 12.98 | 15 | 94564 | 663 | 32418284 |
Irritability | 17.39 | 12.98 | 28 | 94551 | 24626 | 32394321 |
Chromosome analysis abnormal | 17.34 | 12.98 | 8 | 94571 | 113 | 32418834 |
Injection site reaction | 17.31 | 12.98 | 6 | 94573 | 11563 | 32407384 |
Cutaneous T-cell lymphoma recurrent | 17.21 | 12.98 | 6 | 94573 | 38 | 32418909 |
Pneumaturia | 17.21 | 12.98 | 6 | 94573 | 38 | 32418909 |
Diverticulitis | 17.14 | 12.98 | 18 | 94561 | 19010 | 32399937 |
5q minus syndrome | 17.08 | 12.98 | 9 | 94570 | 172 | 32418775 |
Skin discolouration | 16.99 | 12.98 | 14 | 94565 | 16599 | 32402348 |
Protein S decreased | 16.95 | 12.98 | 6 | 94573 | 40 | 32418907 |
Sinusitis bacterial | 16.91 | 12.98 | 11 | 94568 | 315 | 32418632 |
Blood cholesterol increased | 16.91 | 12.98 | 16 | 94563 | 17741 | 32401206 |
Ocular hyperaemia | 16.91 | 12.98 | 4 | 94575 | 9897 | 32409050 |
Neutrophil percentage decreased | 16.90 | 12.98 | 12 | 94567 | 398 | 32418549 |
Protein C decreased | 16.86 | 12.98 | 5 | 94574 | 17 | 32418930 |
Taeniasis | 16.81 | 12.98 | 7 | 94572 | 76 | 32418871 |
Psychomotor hyperactivity | 16.78 | 12.98 | 3 | 94576 | 9036 | 32409911 |
Peripheral sensorimotor neuropathy | 16.73 | 12.98 | 21 | 94558 | 1446 | 32417501 |
Ototoxicity | 16.70 | 12.98 | 22 | 94557 | 1590 | 32417357 |
Therapy responder | 16.67 | 12.98 | 9 | 94570 | 181 | 32418766 |
Blood HIV RNA increased | 16.64 | 12.98 | 22 | 94557 | 1595 | 32417352 |
Dystrophic calcification | 16.61 | 12.98 | 4 | 94575 | 4 | 32418943 |
Heart rate increased | 16.57 | 12.98 | 64 | 94515 | 41764 | 32377183 |
Diaphragm muscle weakness | 16.56 | 12.98 | 8 | 94571 | 126 | 32418821 |
Type 2 diabetes mellitus | 16.51 | 12.98 | 12 | 94567 | 15160 | 32403787 |
Vasogenic cerebral oedema | 16.50 | 12.98 | 13 | 94566 | 506 | 32418441 |
Dyspnoea exertional | 16.50 | 12.98 | 58 | 94521 | 38903 | 32380044 |
Dyskinesia | 16.47 | 12.98 | 27 | 94552 | 23576 | 32395371 |
Peripheral T-cell lymphoma unspecified stage III | 16.46 | 12.98 | 6 | 94573 | 44 | 32418903 |
Platelet count abnormal | 16.42 | 12.98 | 28 | 94551 | 2546 | 32416401 |
Hypertension | 16.38 | 12.98 | 277 | 94302 | 131473 | 32287474 |
Skin toxicity | 16.36 | 12.98 | 35 | 94544 | 3771 | 32415176 |
Fungal sepsis | 16.35 | 12.98 | 17 | 94562 | 953 | 32417994 |
Mediastinal mass | 16.32 | 12.98 | 9 | 94570 | 189 | 32418758 |
Intracranial pressure increased | 16.32 | 12.98 | 35 | 94544 | 3778 | 32415169 |
Skin cancer | 16.30 | 12.98 | 3 | 94576 | 8847 | 32410100 |
Central nervous system enteroviral infection | 16.23 | 12.98 | 6 | 94573 | 46 | 32418901 |
Helicobacter sepsis | 16.23 | 12.98 | 5 | 94574 | 20 | 32418927 |
Adenocarcinoma gastric | 16.20 | 12.98 | 19 | 94560 | 1219 | 32417728 |
Premature ageing | 16.19 | 12.98 | 7 | 94572 | 84 | 32418863 |
Precursor T-lymphoblastic lymphoma/leukaemia | 16.19 | 12.98 | 7 | 94572 | 84 | 32418863 |
Urinary bladder rupture | 16.19 | 12.98 | 7 | 94572 | 84 | 32418863 |
Klebsiella sepsis | 16.12 | 12.98 | 23 | 94556 | 1793 | 32417154 |
B-lymphocyte count decreased | 16.11 | 12.98 | 13 | 94566 | 524 | 32418423 |
Proteinuria | 16.11 | 12.98 | 16 | 94563 | 17339 | 32401608 |
T-cell lymphoma recurrent | 16.01 | 12.98 | 6 | 94573 | 48 | 32418899 |
Cranial nerve disorder | 15.92 | 12.98 | 12 | 94567 | 437 | 32418510 |
Bladder cancer | 15.91 | 12.98 | 5 | 94574 | 10251 | 32408696 |
Swollen tongue | 15.90 | 12.98 | 10 | 94569 | 13629 | 32405318 |
Acinetobacter infection | 15.77 | 12.98 | 18 | 94561 | 1122 | 32417825 |
Sinus bradycardia | 15.76 | 12.98 | 9 | 94570 | 12929 | 32406018 |
Coma | 15.75 | 12.98 | 67 | 94512 | 42545 | 32376402 |
Enterovirus test positive | 15.70 | 12.98 | 6 | 94573 | 51 | 32418896 |
Lentigo | 15.65 | 12.98 | 11 | 94568 | 359 | 32418588 |
Hepatitis B DNA increased | 15.53 | 12.98 | 13 | 94566 | 552 | 32418395 |
Ventricular tachycardia | 15.38 | 12.98 | 32 | 94547 | 25524 | 32393423 |
Astrocytoma malignant | 15.35 | 12.98 | 4 | 94575 | 7 | 32418940 |
Embolism | 15.34 | 12.98 | 52 | 94527 | 7362 | 32411585 |
Fibrosarcoma | 15.33 | 12.98 | 5 | 94574 | 25 | 32418922 |
Transplant rejection | 15.29 | 12.98 | 5 | 94574 | 9994 | 32408953 |
Refractory cytopenia with multilineage dysplasia | 15.27 | 12.98 | 8 | 94571 | 151 | 32418796 |
Exposure during pregnancy | 15.23 | 12.98 | 4 | 94575 | 9225 | 32409722 |
Eosinophilia | 15.23 | 12.98 | 31 | 94548 | 24927 | 32394020 |
Subclavian vein thrombosis | 15.20 | 12.98 | 16 | 94563 | 910 | 32418037 |
Adult T-cell lymphoma/leukaemia | 15.17 | 12.98 | 10 | 94569 | 293 | 32418654 |
Meningitis tuberculous | 15.08 | 12.98 | 14 | 94565 | 683 | 32418264 |
Superior vena cava syndrome | 15.06 | 12.98 | 13 | 94566 | 576 | 32418371 |
Skin laceration | 15.05 | 12.98 | 8 | 94571 | 11958 | 32406989 |
Neck pain | 15.04 | 12.98 | 27 | 94552 | 22760 | 32396187 |
Obstructive airways disorder | 15.04 | 12.98 | 8 | 94571 | 11953 | 32406994 |
Cavernous sinus thrombosis | 15.03 | 12.98 | 8 | 94571 | 156 | 32418791 |
Follicular lymphoma | 15.02 | 12.98 | 6 | 94573 | 58 | 32418889 |
Ganglioneuroma | 15 | 12.98 | 4 | 94575 | 8 | 32418939 |
Respiratory depression | 14.97 | 12.98 | 10 | 94569 | 13201 | 32405746 |
Mononeuropathy multiplex | 14.94 | 12.98 | 8 | 94571 | 158 | 32418789 |
No adverse event | 14.89 | 12.98 | 22 | 94557 | 20031 | 32398916 |
Wound | 14.88 | 12.98 | 10 | 94569 | 13157 | 32405790 |
Gastrointestinal injury | 14.78 | 12.98 | 11 | 94568 | 393 | 32418554 |
Non-alcoholic steatohepatitis | 14.75 | 12.98 | 15 | 94564 | 819 | 32418128 |
Viral load increased | 14.75 | 12.98 | 30 | 94549 | 3120 | 32415827 |
Congenital hepatobiliary anomaly | 14.71 | 12.98 | 5 | 94574 | 29 | 32418918 |
Ill-defined disorder | 14.66 | 12.98 | 71 | 94508 | 11818 | 32407129 |
Aplastic anaemia | 14.63 | 12.98 | 51 | 94528 | 7322 | 32411625 |
Medication error | 14.61 | 12.98 | 27 | 94552 | 22508 | 32396439 |
Philadelphia chromosome positive | 14.56 | 12.98 | 10 | 94569 | 314 | 32418633 |
Salivary gland atrophy | 14.53 | 12.98 | 3 | 94576 | 0 | 32418947 |
Alveolar rhabdomyosarcoma | 14.53 | 12.98 | 3 | 94576 | 0 | 32418947 |
Anal candidiasis | 14.53 | 12.98 | 3 | 94576 | 0 | 32418947 |
Rash maculo-papular | 14.52 | 12.98 | 38 | 94541 | 27984 | 32390963 |
Paternal exposure timing unspecified | 14.43 | 12.98 | 5 | 94574 | 31 | 32418916 |
Klebsiella bacteraemia | 14.40 | 12.98 | 18 | 94561 | 1234 | 32417713 |
Acute respiratory distress syndrome | 14.39 | 12.98 | 124 | 94455 | 25129 | 32393818 |
Human metapneumovirus test positive | 14.34 | 12.98 | 6 | 94573 | 66 | 32418881 |
Gliosis | 14.34 | 12.98 | 8 | 94571 | 172 | 32418775 |
Mantle cell lymphoma stage IV | 14.26 | 12.98 | 6 | 94573 | 67 | 32418880 |
Retinal pigment epitheliopathy | 14.24 | 12.98 | 9 | 94570 | 245 | 32418702 |
Hypertensive crisis | 14.22 | 12.98 | 4 | 94575 | 8813 | 32410134 |
Neurological decompensation | 14.21 | 12.98 | 27 | 94552 | 2671 | 32416276 |
Muscle twitching | 14.14 | 12.98 | 4 | 94575 | 8780 | 32410167 |
Cytomegalovirus enterocolitis | 14.13 | 12.98 | 15 | 94564 | 862 | 32418085 |
Paresis | 14.12 | 12.98 | 23 | 94556 | 2014 | 32416933 |
Lung adenocarcinoma stage I | 14.12 | 12.98 | 4 | 94575 | 11 | 32418936 |
Lewis-Sumner syndrome | 14.04 | 12.98 | 5 | 94574 | 34 | 32418913 |
Rectal adenoma | 14.04 | 12.98 | 5 | 94574 | 34 | 32418913 |
Coronary artery occlusion | 13.98 | 12.98 | 8 | 94571 | 11477 | 32407470 |
Frequent bowel movements | 13.98 | 12.98 | 5 | 94574 | 9447 | 32409500 |
Candida pneumonia | 13.97 | 12.98 | 10 | 94569 | 336 | 32418611 |
Hypouricaemia | 13.95 | 12.98 | 9 | 94570 | 254 | 32418693 |
Miosis | 13.94 | 12.98 | 4 | 94575 | 8700 | 32410247 |
Retinoblastoma | 13.92 | 12.98 | 5 | 94574 | 35 | 32418912 |
Eye excision | 13.92 | 12.98 | 5 | 94574 | 35 | 32418912 |
Optic nerve disorder | 13.90 | 12.98 | 13 | 94566 | 640 | 32418307 |
Tooth disorder | 13.87 | 12.98 | 6 | 94573 | 10101 | 32408846 |
Peripheral T-cell lymphoma unspecified refractory | 13.86 | 12.98 | 4 | 94575 | 12 | 32418935 |
Deafness neurosensory | 13.86 | 12.98 | 27 | 94552 | 2721 | 32416226 |
Vocal cord paresis | 13.81 | 12.98 | 7 | 94572 | 123 | 32418824 |
Disorder of orbit | 13.80 | 12.98 | 6 | 94573 | 73 | 32418874 |
Cryptococcosis | 13.77 | 12.98 | 23 | 94556 | 2057 | 32416890 |
Angiodysplasia | 13.71 | 12.98 | 12 | 94567 | 542 | 32418405 |
Guillain-Barre syndrome | 13.70 | 12.98 | 41 | 94538 | 5433 | 32413514 |
Blood urea increased | 13.69 | 12.98 | 48 | 94531 | 32225 | 32386722 |
Neuroborreliosis | 13.68 | 12.98 | 5 | 94574 | 37 | 32418910 |
Retroperitoneal lymphadenopathy | 13.67 | 12.98 | 14 | 94565 | 771 | 32418176 |
Accidental overdose | 13.61 | 12.98 | 22 | 94557 | 19317 | 32399630 |
Abnormal dreams | 13.60 | 12.98 | 4 | 94575 | 8560 | 32410387 |
Joint stiffness | 13.54 | 12.98 | 6 | 94573 | 9959 | 32408988 |
Panic attack | 13.52 | 12.98 | 5 | 94574 | 9256 | 32409691 |
Iris atrophy | 13.52 | 12.98 | 6 | 94573 | 77 | 32418870 |
Pulmonary oedema | 13.52 | 12.98 | 79 | 94500 | 46188 | 32372759 |
Mastitis | 13.51 | 12.98 | 8 | 94571 | 193 | 32418754 |
Kidney transplant rejection | 13.51 | 12.98 | 3 | 94576 | 7752 | 32411195 |
Bladder spasm | 13.51 | 12.98 | 15 | 94564 | 907 | 32418040 |
Arteriosclerosis coronary artery | 13.46 | 12.98 | 9 | 94570 | 11872 | 32407075 |
Acinetobacter sepsis | 13.45 | 12.98 | 5 | 94574 | 39 | 32418908 |
Abdominal mass | 13.45 | 12.98 | 18 | 94561 | 1321 | 32417626 |
Haematuria | 13.38 | 12.98 | 84 | 94495 | 48277 | 32370670 |
Mucosal toxicity | 13.37 | 12.98 | 8 | 94571 | 197 | 32418750 |
Enteritis | 13.36 | 12.98 | 49 | 94530 | 7212 | 32411735 |
Meningoradiculitis | 13.35 | 12.98 | 5 | 94574 | 40 | 32418907 |
Pneumothorax spontaneous | 13.35 | 12.98 | 11 | 94568 | 457 | 32418490 |
Gastrointestinal mucosal disorder | 13.32 | 12.98 | 10 | 94569 | 362 | 32418585 |
Hepatitis fulminant | 13.32 | 12.98 | 34 | 94545 | 4109 | 32414838 |
Deafness | 13.30 | 12.98 | 65 | 94514 | 10860 | 32408087 |
Splenic candidiasis | 13.25 | 12.98 | 6 | 94573 | 81 | 32418866 |
Chronic lymphocytic leukaemia transformation | 13.23 | 12.98 | 8 | 94571 | 201 | 32418746 |
White blood cell count abnormal | 13.22 | 12.98 | 28 | 94551 | 2996 | 32415951 |
Meningitis bacterial | 13.22 | 12.98 | 17 | 94562 | 1200 | 32417747 |
Blood urine present | 13.20 | 12.98 | 7 | 94572 | 10478 | 32408469 |
Postural tremor | 13.20 | 12.98 | 10 | 94569 | 367 | 32418580 |
Human polyomavirus infection | 13.18 | 12.98 | 13 | 94566 | 684 | 32418263 |
Acute myocardial infarction | 13.18 | 12.98 | 100 | 94479 | 55049 | 32363898 |
Renal disorder | 13.17 | 12.98 | 34 | 94545 | 25149 | 32393798 |
Feeling hot | 13.06 | 12.98 | 18 | 94561 | 16868 | 32402079 |
Cancer fatigue | 13.03 | 12.98 | 5 | 94574 | 43 | 32418904 |
Hepatosplenic T-cell lymphoma | 13.02 | 12.98 | 11 | 94568 | 473 | 32418474 |
Neoplasm | 13.01 | 12.98 | 35 | 94544 | 4366 | 32414581 |
Areflexia | 13.00 | 12.98 | 27 | 94552 | 2849 | 32416098 |
Necrotic lymphadenopathy | 12.98 | 12.98 | 4 | 94575 | 16 | 32418931 |
Source | Code | Description |
---|---|---|
ATC | L01CA02 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS Vinca alkaloids and analogues |
FDA CS | M0022674 | Vinca Alkaloids |
MeSH PA | D050256 | Antimitotic Agents |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D000972 | Antineoplastic Agents, Phytogenic |
MeSH PA | D050257 | Tubulin Modulators |
FDA EPC | N0000175612 | Vinca Alkaloid |
CHEBI has role | CHEBI:23888 | drugs |
CHEBI has role | CHEBI:35610 | cytostatic |
CHEBI has role | CHEBI:60832 | tubulin modulators |
CHEBI has role | CHEBI:61951 | microtubule destabilising role |
CHEBI has role | CHEBI:76924 | plant metabolites |
CHEBI has role | CHEBI:176497 | anti-aging drugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Acute lymphoid leukemia | indication | 91857003 | DOID:9952 |
Diffuse non-Hodgkin's lymphoma, large cell | indication | 109969005 | |
Hodgkin's disease | indication | 118599009 | |
Non-Hodgkin's lymphoma | indication | 118601006 | |
Burkitt's lymphoma | indication | 118617000 | |
Rhabdomyosarcoma | indication | 302847003 | DOID:3247 |
Nephroblastoma | indication | 302849000 | DOID:2154 |
Follicular non-Hodgkin's lymphoma | indication | 308121000 | |
Neuroblastoma | indication | 432328008 | DOID:769 |
Astrocytoma, anaplastic | off-label use | 55353007 | DOID:3078 |
Ewing's sarcoma | off-label use | 76909002 | DOID:3369 |
Chronic lymphoid leukemia, disease | off-label use | 92814006 | |
Multiple myeloma | off-label use | 109989006 | DOID:9538 |
Mycosis fungoides | off-label use | 118618005 | |
Small cell carcinoma of lung | off-label use | 254632001 | DOID:5409 |
Glioblastoma multiforme of brain | off-label use | 276828006 | DOID:3073 |
Primary cutaneous T-cell lymphoma | off-label use | 400122007 | |
Ovarian Germ Cell Tumor Carcinoma | off-label use | ||
Mycosis | contraindication | 3218000 | DOID:1564 |
Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
Obstruction of bile duct | contraindication | 30144000 | |
Viral disease | contraindication | 34014006 | DOID:934 |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Charcot-Marie-Tooth disease | contraindication | 50548001 | |
Hepatic failure | contraindication | 59927004 | |
Leukopenia | contraindication | 84828003 | DOID:615 |
Bacterial infectious disease | contraindication | 87628006 | |
Peripheral motor neuropathy | contraindication | 95663000 | DOID:683 |
Neuromyopathy | contraindication | 255522009 | DOID:440 |
Uric acid renal calculus | contraindication | 274401005 | |
Pregnancy, function | contraindication | 289908002 | |
Peripheral nerve disease | contraindication | 302226006 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Chronic lung disease | contraindication | 413839001 | |
Protozoal Infection | contraindication | ||
Polyneuropathies | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 10.02 | acidic |
pKa2 | 13.81 | acidic |
pKa3 | 7.2 | Basic |
pKa4 | 6.58 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Tubulin beta | Tumour-associated antigen | INHIBITOR | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||||
Multidrug resistance protein 1 | Transporter | WOMBAT-PK | |||||||
Canalicular multispecific organic anion transporter 1 | Transporter | WOMBAT-PK | |||||||
Multidrug resistance-associated protein 1 | Transporter | WOMBAT-PK | |||||||
Multidrug resistance-associated protein 7 | Transporter | WOMBAT-PK | |||||||
Tubulin | Structural | IC50 | 5.74 | CHEMBL |
ID | Source |
---|---|
4019971 | VUID |
N0000148056 | NUI |
D02197 | KEGG_DRUG |
2068-78-2 | SECONDARY_CAS_RN |
4017542 | VANDF |
4019971 | VANDF |
C0042679 | UMLSCUI |
CHEBI:28445 | CHEBI |
R1Q | PDB_CHEM_ID |
CHEMBL90555 | ChEMBL_ID |
CHEMBL501867 | ChEMBL_ID |
D014750 | MESH_DESCRIPTOR_UI |
DB00541 | DRUGBANK_ID |
6785 | IUPHAR_LIGAND_ID |
1440 | INN_ID |
5J49Q6B70F | UNII |
5978 | PUBCHEM_CID |
11202 | RXNORM |
5133 | MMSL |
5675 | MMSL |
7308 | MMSL |
879 | MMSL |
d00401 | MMSL |
002656 | NDDF |
004894 | NDDF |
23079006 | SNOMEDCT_US |
387126006 | SNOMEDCT_US |
387427007 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Vincasar PFS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-4402 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | ANDA | 20 sections |
Vincasar PFS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-4412 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | ANDA | 20 sections |
VinCRIStine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61703-309 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | ANDA | 22 sections |
VinCRIStine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61703-309 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | ANDA | 22 sections |