vincristine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
vinca alkaloids 2825 57-22-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vincristine
  • (+)-Vincristine
  • leucristine
  • vincristin
  • vinkristin
  • 22-oxo-vincaleukoblastine
  • vincristine sulfate
  • oncovin
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
  • Molecular weight: 824.97
  • Formula: C46H56N4O10
  • CLOGP: 4.04
  • LIPINSKI: 2
  • HAC: 14
  • HDO: 3
  • TPSA: 171.17
  • ALOGS: -4.44
  • ROTB: 10

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 15 % Benet LZ, Broccatelli F, Oprea TI
Vd (Volume of distribution) 2.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.40 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 23 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 10, 1963 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 3499.59 13.66 1977 64293 92650 46527142
Neutropenia 1354.71 13.66 1316 64954 141888 46477904
Febrile bone marrow aplasia 839.51 13.66 329 65941 6533 46613259
Product use in unapproved indication 638.05 13.66 711 65559 89562 46530230
Bone marrow failure 607.66 13.66 428 65842 29241 46590551
Haematotoxicity 546.43 13.66 243 66027 6690 46613102
Mucosal inflammation 537.14 13.66 444 65826 38532 46581260
Pancytopenia 521.94 13.66 623 65647 84435 46535357
Myelodysplastic syndrome 492.24 13.66 296 65974 15415 46604377
Diffuse large B-cell lymphoma recurrent 487.06 13.66 149 66121 1343 46618449
Posterior reversible encephalopathy syndrome 476.27 13.66 286 65984 14855 46604937
Second primary malignancy 475.13 13.66 217 66053 6367 46613425
Acute myeloid leukaemia 467.94 13.66 287 65983 15491 46604301
Thrombocytopenia 426.85 13.66 695 65575 125886 46493906
Tumour lysis syndrome 416.26 13.66 204 66066 7032 46612760
Sepsis 401.84 13.66 704 65566 135310 46484482
Venoocclusive liver disease 383.82 13.66 164 66106 4087 46615705
Septic shock 369.69 13.66 433 65837 57460 46562332
Diffuse large B-cell lymphoma 322.51 13.66 161 66109 5777 46614015
Rheumatoid arthritis 320.06 13.66 4 66266 240211 46379581
Acute lymphocytic leukaemia recurrent 319.41 13.66 118 66152 1977 46617815
Neurotoxicity 318.73 13.66 214 66056 13503 46606289
Hypofibrinogenaemia 303.64 13.66 96 66174 974 46618818
Pyrexia 294.82 13.66 1123 65147 347679 46272113
Ovarian failure 286.09 13.66 93 66177 1039 46618753
Neutropenic sepsis 280.90 13.66 190 66080 12134 46607658
Hepatitis B 279.98 13.66 126 66144 3567 46616225
Pain 274.05 13.66 170 66100 476778 46143014
Progressive multifocal leukoencephalopathy 249.28 13.66 171 66099 11175 46608617
Fall 238.42 13.66 85 66185 329012 46290780
Acute lymphocytic leukaemia 237.26 13.66 103 66167 2670 46617122
Staphylococcal bacteraemia 223.04 13.66 118 66152 4786 46615006
Maternal exposure before pregnancy 218.58 13.66 113 66157 4368 46615424
Cardiotoxicity 216.58 13.66 129 66141 6593 46613199
Diffuse large B-cell lymphoma refractory 214.75 13.66 72 66198 892 46618900
Disease recurrence 200.92 13.66 184 66086 18287 46601505
Haemophagocytic lymphohistiocytosis 195.82 13.66 131 66139 8211 46611581
Aplasia 194.31 13.66 97 66173 3479 46616313
Multiple organ dysfunction syndrome 190.52 13.66 296 65974 51414 46568378
Product dose omission issue 185.86 13.66 14 66256 168506 46451286
Off label use 184.30 13.66 1040 65230 378801 46240991
Neutrophil count decreased 183.43 13.66 265 66005 43161 46576631
Disease progression 180.96 13.66 400 65870 90900 46528892
Neuropathy peripheral 175.41 13.66 394 65876 90499 46529293
Joint swelling 174.40 13.66 17 66253 166056 46453736
Leukopenia 168.98 13.66 328 65942 68015 46551777
B-cell lymphoma recurrent 166.29 13.66 49 66221 383 46619409
Pneumocystis jirovecii pneumonia 166.04 13.66 152 66118 15096 46604696
Pruritus 164.73 13.66 69 66201 242283 46377509
Hypertriglyceridaemia 164.58 13.66 102 66168 5602 46614190
Ileus paralytic 163.29 13.66 92 66178 4231 46615561
Drug hypersensitivity 163.21 13.66 71 66199 243754 46376038
Post transplant lymphoproliferative disorder 161.94 13.66 88 66182 3768 46616024
Neutropenic colitis 159.23 13.66 73 66197 2159 46617633
Nasopharyngitis 158.49 13.66 17 66253 153981 46465811
Platelet count decreased 157.83 13.66 401 65869 99623 46520169
Dizziness 155.09 13.66 153 66117 340261 46279531
Myelosuppression 154.95 13.66 110 66160 7593 46612199
Drug resistance 154.75 13.66 155 66115 17213 46602579
Headache 153.98 13.66 278 65992 478074 46141718
Fatigue 153.00 13.66 406 65864 608291 46011501
Neoplasm progression 151.25 13.66 188 66082 26495 46593297
Epstein-Barr virus infection 146.07 13.66 101 66169 6683 46613109
Arthralgia 144.11 13.66 184 66086 364419 46255373
Abdominal discomfort 140.49 13.66 23 66247 151142 46468650
Hyperbilirubinaemia 139.67 13.66 117 66153 10321 46609471
Neoplasm recurrence 136.75 13.66 67 66203 2306 46617486
Anxiety 135.00 13.66 45 66225 181912 46437880
Peripheral swelling 134.30 13.66 30 66240 158041 46461751
Cardiomyopathy 129.70 13.66 136 66134 15937 46603855
Feeling abnormal 125.65 13.66 15 66255 125045 46494747
Cytopenia 122.83 13.66 96 66174 7672 46612120
Leukoencephalopathy 121.64 13.66 74 66196 3930 46615862
Hepatitis B reactivation 119.05 13.66 53 66217 1461 46618331
Mucormycosis 118.16 13.66 60 66210 2232 46617560
Injection site pain 117.81 13.66 9 66261 107143 46512649
Malignant neoplasm progression 116.96 13.66 274 65996 64652 46555140
Insomnia 116.83 13.66 44 66226 164880 46454912
Weight increased 116.31 13.66 44 66226 164429 46455363
Bacteraemia 116.25 13.66 121 66149 14058 46605734
Pneumatosis intestinalis 116.17 13.66 57 66213 1968 46617824
Rash 114.70 13.66 207 66063 356305 46263487
Blood culture positive 111.08 13.66 73 66197 4439 46615353
Temporal lobe epilepsy 107.17 13.66 34 66236 349 46619443
Cerebral venous thrombosis 104.77 13.66 54 66216 2073 46617719
Malaise 103.25 13.66 196 66074 331036 46288756
Disseminated intravascular coagulation 101.49 13.66 130 66140 18875 46600917
Drug ineffective 100.86 13.66 559 65711 677279 45942513
Secondary immunodeficiency 98.84 13.66 41 66229 946 46618846
Lymphopenia 98.51 13.66 115 66155 15178 46604614
Blood lactate dehydrogenase increased 96.78 13.66 132 66138 20368 46599424
Contraindicated product administered 96.19 13.66 4 66266 79943 46539849
Lennox-Gastaut syndrome 96.12 13.66 29 66241 248 46619544
Dyspnoea 95.98 13.66 392 65878 515156 46104636
White blood cell count decreased 95.57 13.66 363 65907 111868 46507924
Myelopathy 95.54 13.66 54 66216 2498 46617294
Systemic candida 94.85 13.66 55 66215 2672 46617120
Polyneuropathy 94.79 13.66 99 66171 11545 46608247
Stem cell transplant 93.29 13.66 47 66223 1719 46618073
Sinusitis 92.93 13.66 34 66236 129734 46490058
Hypogammaglobulinaemia 92.08 13.66 70 66200 5368 46614424
Fungaemia 90.79 13.66 48 66222 1943 46617849
Arthropathy 90.65 13.66 8 66262 84692 46535100
Asthma 89.46 13.66 12 66258 91530 46528262
Musculoskeletal stiffness 88.61 13.66 16 66254 97977 46521815
Pain in extremity 86.91 13.66 146 66124 258534 46361258
Blood pressure increased 86.06 13.66 36 66234 126630 46493162
Drug intolerance 86.05 13.66 51 66219 146998 46472794
Venoocclusive disease 85.93 13.66 46 66224 1910 46617882
Hepatocellular injury 85.84 13.66 152 66118 29370 46590422
Pleural effusion 84.00 13.66 284 65986 82668 46537124
Overdose 83.33 13.66 21 66249 101958 46517834
Central nervous system lymphoma 83.18 13.66 39 66231 1215 46618577
Swelling 82.03 13.66 37 66233 124474 46495318
Hepatic failure 80.85 13.66 159 66111 33257 46586535
Cerebral venous sinus thrombosis 80.40 13.66 43 66227 1782 46618010
Epstein-Barr virus associated lymphoproliferative disorder 80.00 13.66 40 66230 1439 46618353
Infection 79.71 13.66 388 65882 133204 46486588
Nephroblastoma 79.26 13.66 21 66249 105 46619687
Depression 78.98 13.66 75 66195 170029 46449763
Anaemia 78.61 13.66 626 65644 255153 46364639
Arthritis 78.32 13.66 9 66261 77307 46542485
Injection site erythema 77.07 13.66 8 66262 74419 46545373
Enterococcal infection 76.74 13.66 70 66200 6917 46612875
Muscle spasms 75.91 13.66 40 66230 123073 46496719
Ejection fraction decreased 75.02 13.66 109 66161 17828 46601964
Drug abuse 73.61 13.66 4 66266 63404 46556388
Ascites 73.19 13.66 161 66109 36423 46583369
B-cell lymphoma 73.17 13.66 50 66220 3244 46616548
Leukaemia recurrent 72.57 13.66 36 66234 1273 46618519
Clostridium difficile colitis 72.21 13.66 109 66161 18444 46601348
Bronchopulmonary aspergillosis 70.66 13.66 69 66201 7427 46612365
Respiratory failure 70.50 13.66 294 65976 94522 46525270
Synovitis 70.44 13.66 4 66266 61071 46558721
Palpitations 69.82 13.66 24 66246 95235 46524557
Bone pain 69.76 13.66 184 66086 46706 46573086
Nausea 69.32 13.66 634 65636 686820 45932972
Smooth muscle cell neoplasm 68.85 13.66 27 66243 536 46619256
Peripheral motor neuropathy 68.48 13.66 36 66234 1440 46618352
Stomatitis 68.40 13.66 233 66037 68064 46551728
Bronchitis 67.48 13.66 33 66237 105946 46513846
Superior sagittal sinus thrombosis 67.35 13.66 30 66240 828 46618964
Gene mutation 66.77 13.66 32 66238 1048 46618744
Enterococcal bacteraemia 65.77 13.66 33 66237 1196 46618596
B precursor type acute leukaemia 65.58 13.66 20 66250 178 46619614
Cystitis haemorrhagic 65.28 13.66 48 66222 3499 46616293
Hospitalisation 65.15 13.66 7 66263 63378 46556414
Pseudomonas test positive 64.76 13.66 28 66242 718 46619074
Chest pain 64.42 13.66 94 66176 176230 46443562
Contusion 64.19 13.66 22 66248 87465 46532327
Aspergillus infection 64.16 13.66 63 66207 6827 46612965
Klebsiella infection 64.06 13.66 62 66208 6600 46613192
Encephalopathy 64.03 13.66 145 66125 33444 46586348
Therapy partial responder 63.71 13.66 53 66217 4629 46615163
Peripheral sensory neuropathy 62.65 13.66 61 66209 6542 46613250
Inappropriate schedule of product administration 62.39 13.66 9 66261 65004 46554788
Migraine 62.09 13.66 12 66258 70014 46549778
Agranulocytosis 60.38 13.66 111 66159 22074 46597718
Colitis 60.14 13.66 151 66119 37196 46582596
Rhinovirus infection 59.80 13.66 46 66224 3590 46616202
Retinoblastoma 59.70 13.66 17 66253 116 46619676
Urticaria 59.51 13.66 48 66222 117844 46501948
Myeloid leukaemia 59.27 13.66 21 66249 310 46619482
Lymphadenopathy 58.82 13.66 140 66130 33348 46586444
Cytomegalovirus infection 58.76 13.66 98 66172 18046 46601746
Abdominal pain upper 58.62 13.66 72 66198 145233 46474559
Therapeutic product effect decreased 58.51 13.66 22 66248 82579 46537213
Refractory anaemia with an excess of blasts 57.23 13.66 22 66248 413 46619379
Escherichia bacteraemia 56.85 13.66 40 66230 2721 46617071
Lymphoma transformation 56.70 13.66 17 66253 142 46619650
Acute myelomonocytic leukaemia 55.86 13.66 18 66252 195 46619597
Ileus 55.26 13.66 83 66187 13981 46605811
Congestive cardiomyopathy 54.62 13.66 53 66217 5660 46614132
Venous thrombosis 52.86 13.66 48 66222 4714 46615078
Injection site reaction 52.62 13.66 4 66266 47845 46571947
Respiratory distress 52.40 13.66 130 66140 31786 46588006
Condition aggravated 52.17 13.66 176 66094 244876 46374916
Intentional product misuse 51.66 13.66 4 66266 47124 46572668
Sleep disorder 51.22 13.66 4 66266 46791 46573001
Fusarium infection 51.18 13.66 22 66248 556 46619236
Human bocavirus infection 51.00 13.66 19 66251 326 46619466
Hepatomegaly 50.91 13.66 71 66199 11182 46608610
Pneumocystis jirovecii infection 50.88 13.66 28 66242 1229 46618563
Pulmonary haemorrhage 50.62 13.66 54 66216 6451 46613341
Antithrombin III decreased 50.12 13.66 18 66252 277 46619515
Glioma 50.06 13.66 18 66252 278 46619514
Osteonecrosis 50.03 13.66 112 66158 25632 46594160
Left ventricular dysfunction 49.86 13.66 67 66203 10188 46609604
Bacterial sepsis 49.83 13.66 41 66229 3526 46616266
Heart rate abnormal 49.56 13.66 40 66230 3347 46616445
Ototoxicity 49.39 13.66 26 66244 1043 46618749
Suicidal ideation 49.27 13.66 10 66260 56372 46563420
Candida infection 49.23 13.66 102 66168 22138 46597654
Cervix disorder 48.64 13.66 20 66250 451 46619341
Device related infection 48.35 13.66 98 66172 20943 46598849
Osteoarthritis 48.34 13.66 14 66256 62011 46557781
Herpes simplex 47.66 13.66 55 66215 7168 46612624
Hyperglycaemia 47.53 13.66 133 66137 34938 46584854
Quadriplegia 47.43 13.66 30 66240 1707 46618085
Human herpesvirus 6 infection 47.14 13.66 34 66236 2405 46617387
Blood fibrinogen decreased 46.84 13.66 22 66248 688 46619104
Premature menopause 46.81 13.66 22 66248 689 46619103
Hyperhidrosis 46.79 13.66 35 66235 89273 46530519
Influenza like illness 46.74 13.66 12 66258 57558 46562234
Pyomyositis 46.19 13.66 18 66252 351 46619441
Enterovirus test positive 46.17 13.66 14 66256 122 46619670
Philadelphia chromosome positive 46.16 13.66 17 66253 282 46619510
Lymphoma 46.02 13.66 63 66207 9750 46610042
Staphylococcal sepsis 45.79 13.66 55 66215 7477 46612315
Cutaneous calcification 45.74 13.66 13 66257 88 46619704
Lung infiltration 45.67 13.66 76 66194 13967 46605825
Diarrhoea 45.65 13.66 542 65728 559060 46060732
Myalgia 45.54 13.66 65 66205 123023 46496769
Toxic neuropathy 45.41 13.66 18 66252 368 46619424
Leukaemia cutis 45.24 13.66 13 66257 92 46619700
Gastrooesophageal reflux disease 44.58 13.66 25 66245 74319 46545473
Pneumonia fungal 44.36 13.66 41 66229 4119 46615673
Neck pain 44 13.66 12 66258 55294 46564498
Choriocarcinoma 43.96 13.66 13 66257 103 46619689
Brain oedema 43.93 13.66 70 66200 12408 46607384
Mantle cell lymphoma recurrent 43.11 13.66 13 66257 111 46619681
Enterobacter infection 42.76 13.66 29 66241 1858 46617934
Injection site swelling 42.62 13.66 4 66266 40323 46579469
Loss of personal independence in daily activities 42.60 13.66 14 66256 57169 46562623
Urinary tract infection 42.36 13.66 165 66105 220101 46399691
B-cell lymphoma refractory 42.12 13.66 12 66258 82 46619710
Incorrect dose administered 42.12 13.66 7 66263 45543 46574249
Osteomyelitis bacterial 42.01 13.66 14 66256 170 46619622
5q minus syndrome 41.86 13.66 14 66256 172 46619620
Injection site pruritus 41.85 13.66 4 66266 39739 46580053
Suicide attempt 41.84 13.66 13 66257 55023 46564769
Hot flush 41.81 13.66 6 66264 43511 46576281
Human rhinovirus test positive 41.64 13.66 13 66257 126 46619666
Inappropriate antidiuretic hormone secretion 41.49 13.66 73 66197 14029 46605763
Back pain 41.25 13.66 156 66114 209883 46409909
Mucosal toxicity 41.01 13.66 16 66254 313 46619479
Intussusception 40.95 13.66 18 66252 481 46619311
Wound 40.89 13.66 6 66264 42796 46576996
Somnolence 40.88 13.66 102 66168 156419 46463373
Cerebrovascular accident 40.80 13.66 50 66220 100989 46518803
Herpes zoster meningoencephalitis 40.78 13.66 15 66255 248 46619544
Hepatitis E 40.49 13.66 24 66246 1215 46618577
Humoral immune defect 40.27 13.66 11 66259 63 46619729
Hypoalbuminaemia 40.12 13.66 60 66210 10067 46609725
Alopecia 40.00 13.66 109 66161 162305 46457487
Histiocytic sarcoma 39.70 13.66 11 66259 67 46619725
Myocardial infarction 39.66 13.66 48 66222 97480 46522312
Combined immunodeficiency 39.63 13.66 12 66258 104 46619688
Perineal necrosis 39.33 13.66 12 66258 107 46619685
Epstein-Barr virus associated lymphoma 39.25 13.66 15 66255 277 46619515
Loss of consciousness 39.21 13.66 58 66212 108180 46511612
Cough 39.03 13.66 181 66089 230068 46389724
Coagulopathy 38.80 13.66 83 66187 18416 46601376
JC virus infection 38.76 13.66 26 66244 1636 46618156
Gastrosplenic fistula 38.61 13.66 10 66260 45 46619747
Transverse sinus thrombosis 38.58 13.66 19 66251 661 46619131
Medulloblastoma recurrent 38.51 13.66 11 66259 76 46619716
Dry mouth 38.27 13.66 15 66255 54911 46564881
Astrocytoma, low grade 38.08 13.66 10 66260 48 46619744
Injury 38.07 13.66 8 66262 44019 46575773
Blood glucose increased 38.01 13.66 28 66242 71985 46547807
Perineal infection 37.84 13.66 12 66258 123 46619669
Plasmablastic lymphoma 37.81 13.66 14 66256 236 46619556
Gastroenteritis norovirus 37.63 13.66 25 66245 1548 46618244
Growth hormone deficiency 37.41 13.66 12 66258 128 46619664
Unmasking of previously unidentified disease 37.28 13.66 19 66251 712 46619080
Cardiac failure 37.23 13.66 217 66053 79731 46540061
Bone marrow disorder 36.93 13.66 26 66244 1770 46618022
Platelet count abnormal 36.93 13.66 31 66239 2741 46617051
Lymphadenitis 36.51 13.66 30 66240 2575 46617217
Adverse drug reaction 36.48 13.66 9 66261 44353 46575439
Therapeutic response delayed 36.19 13.66 17 66253 532 46619260
Chest discomfort 36.10 13.66 45 66225 90224 46529568
Depressed mood 36.04 13.66 3 66267 33316 46586476
Vision blurred 35.96 13.66 36 66234 79672 46540120
Acute promyelocytic leukaemia 35.87 13.66 20 66250 901 46618891
Oedema peripheral 35.83 13.66 112 66158 159594 46460198
Lymphoproliferative disorder 35.65 13.66 30 66240 2662 46617130
Clostridium test positive 35.57 13.66 26 66244 1878 46617914
Listeria sepsis 35.21 13.66 17 66253 566 46619226
Recurrent cancer 35.10 13.66 25 66245 1734 46618058
Unevaluable event 34.93 13.66 11 66259 46164 46573628
Malignant transformation 34.66 13.66 14 66256 301 46619491
Burning sensation 34.65 13.66 10 66260 44401 46575391
Cytomegalovirus viraemia 34.54 13.66 37 66233 4441 46615351
Bacterial infection 34.29 13.66 73 66197 16143 46603649
Acute hepatitis B 34.24 13.66 14 66256 311 46619481
Glioblastoma multiforme 34.05 13.66 19 66251 857 46618935
T-cell lymphoma 33.99 13.66 17 66253 612 46619180
Cytomegalovirus chorioretinitis 33.77 13.66 23 66247 1484 46618308
Discomfort 33.77 13.66 12 66258 46658 46573134
Erythropoiesis abnormal 33.72 13.66 13 66257 246 46619546
Tremor 33.71 13.66 71 66199 115568 46504224
Memory impairment 33.68 13.66 36 66234 77301 46542491
Femur fracture 33.52 13.66 6 66264 36991 46582801
Nail pigmentation 33.45 13.66 12 66258 184 46619608
Cytogenetic abnormality 33.44 13.66 16 66254 522 46619270
Leukaemic lymphoma 33.41 13.66 10 66260 83 46619709
Infection reactivation 32.94 13.66 18 66252 779 46619013
Mobility decreased 32.71 13.66 23 66247 60571 46559221
Pneumonia cytomegaloviral 32.68 13.66 25 66245 1935 46617857
Areflexia 32.64 13.66 30 66240 2993 46616799
General physical health deterioration 32.58 13.66 278 65992 115491 46504301
Blast cells present 32.45 13.66 14 66256 357 46619435
Seizure 32.30 13.66 291 65979 122763 46497029
Blood pressure fluctuation 32.23 13.66 3 66267 30445 46589347
Cardiomyopathy acute 32.21 13.66 12 66258 206 46619586
Hemiparesis 32.15 13.66 81 66189 19988 46599804
Rhinocerebral mucormycosis 31.98 13.66 11 66259 148 46619644
Vocal cord paralysis 31.91 13.66 23 66247 1625 46618167
Cryptococcosis 31.82 13.66 18 66252 834 46618958
Hepatic infarction 31.68 13.66 16 66254 588 46619204
Oesophageal candidiasis 31.66 13.66 38 66232 5162 46614630
Subdural hygroma 31.48 13.66 12 66258 220 46619572
Leukoerythroblastosis 31.48 13.66 12 66258 220 46619572
Hyperammonaemia 31.26 13.66 36 66234 4680 46615112
Hypersensitivity 31.24 13.66 109 66161 150212 46469580
Capillary leak syndrome 31.20 13.66 24 66246 1873 46617919
Hallucination 31.11 13.66 16 66254 49935 46569857
Varicella zoster virus infection 30.80 13.66 26 66244 2317 46617475
Encephalitis 30.76 13.66 45 66225 7403 46612389
Cholestasis 30.73 13.66 96 66174 26797 46592995
Pseudomonas infection 30.65 13.66 52 66218 9706 46610086
Antithrombin III 30.58 13.66 11 66259 170 46619622
Acute respiratory distress syndrome 30.55 13.66 84 66186 21838 46597954
Trichodysplasia spinulosa 30.50 13.66 14 66256 415 46619377
Chronic kidney disease 30.45 13.66 10 66260 40861 46578931
White blood cell count abnormal 30.42 13.66 37 66233 5095 46614697
Candida test positive 30.12 13.66 18 66252 925 46618867
Gestational trophoblastic tumour 30.03 13.66 8 66262 41 46619751
Carotid intima-media thickness increased 29.83 13.66 9 66261 77 46619715
Therapy responder 29.76 13.66 13 66257 342 46619450
Ureaplasma infection 29.54 13.66 14 66256 447 46619345
Nasal congestion 29.10 13.66 16 66254 48097 46571695
Musculoskeletal pain 29.05 13.66 34 66236 70094 46549698
Hyperpyrexia 28.99 13.66 27 66243 2739 46617053
Klebsiella bacteraemia 28.88 13.66 19 66251 1157 46618635
Feeling hot 28.75 13.66 9 66261 37919 46581873
Acute biphenotypic leukaemia 28.70 13.66 8 66262 50 46619742
Nephrolithiasis 28.59 13.66 6 66264 33045 46586747
Hepatotoxicity 28.32 13.66 89 66181 24920 46594872
Desmoplastic small round cell tumour 28.08 13.66 10 66260 150 46619642
Pseudomonal sepsis 27.94 13.66 23 66247 1979 46617813
Product quality issue 27.86 13.66 8 66262 35640 46584152
Therapy non-responder 27.78 13.66 124 66146 41028 46578764
International normalised ratio increased 27.76 13.66 16 66254 46867 46572925
Surgery 27.58 13.66 4 66266 28781 46591011
Subclavian vein thrombosis 27.43 13.66 22 66248 1824 46617968
Flushing 27.12 13.66 31 66239 64583 46555209
Leukaemia 26.79 13.66 28 66242 3267 46616525
B-cell type acute leukaemia 26.59 13.66 9 66261 115 46619677
Cerebellar stroke 26.56 13.66 10 66260 177 46619615
Paraparesis 26.48 13.66 22 66248 1917 46617875
Dyspepsia 26.48 13.66 35 66235 68437 46551355
BK virus infection 26.43 13.66 26 66244 2823 46616969
Premature delivery 26.35 13.66 80 66190 21989 46597803
Escherichia test positive 26.16 13.66 22 66248 1950 46617842
Pulse waveform abnormal 26.15 13.66 8 66262 72 46619720
Potentiating drug interaction 26.10 13.66 30 66240 3893 46615899
Sinusitis fungal 26.09 13.66 16 66254 862 46618930
Ankle brachial index decreased 26.06 13.66 8 66262 73 46619719
Ocular vascular disorder 25.86 13.66 12 66258 365 46619427
Rhinorrhoea 25.84 13.66 18 66252 47647 46572145
Toxic cardiomyopathy 25.71 13.66 9 66261 128 46619664
Acquired gene mutation 25.70 13.66 14 66256 602 46619190
Emotional distress 25.70 13.66 6 66264 30701 46589091
Traumatic lung injury 25.53 13.66 19 66251 1411 46618381
Flatulence 25.48 13.66 5 66265 28873 46590919
Hypertransaminasaemia 25.47 13.66 28 66242 3460 46616332
Haemorrhage intracranial 25.44 13.66 56 66214 12668 46607124
Joint stiffness 25.43 13.66 4 66266 27104 46592688
Metastasis 25.42 13.66 31 66239 4281 46615511
Refractory cytopenia with multilineage dysplasia 25.39 13.66 9 66261 133 46619659
Haemolytic uraemic syndrome 25.31 13.66 24 66246 2490 46617302
Tumour necrosis 25.29 13.66 15 66255 760 46619032
Primary immunodeficiency syndrome 25.21 13.66 7 66263 43 46619749
Heart rate decreased 25.01 13.66 7 66263 31716 46588076
Weight decreased 24.92 13.66 186 66084 210663 46409129
Hepatitis C RNULL increased 24.68 13.66 9 66261 145 46619647
Mucoepidermoid carcinoma 24.68 13.66 7 66263 47 46619745
Bone marrow transplant 24.60 13.66 14 66256 656 46619136
Clostridium difficile infection 24.55 13.66 85 66185 25018 46594774
Metastases to meninges 24.54 13.66 21 66249 1906 46617886
Chronic hepatitis 24.44 13.66 15 66255 809 46618983
Intestinal perforation 24.29 13.66 50 66220 10801 46608991
Wheezing 24.21 13.66 24 66246 53362 46566430
Hereditary motor and sensory neuropathy 24.18 13.66 7 66263 51 46619741
Pneumonia 24.18 13.66 702 65568 375618 46244174
IIIrd nerve paralysis 24.16 13.66 14 66256 679 46619113
Rhabdomyosarcoma recurrent 24.14 13.66 6 66264 22 46619770
Soft tissue infection 24.05 13.66 21 66249 1959 46617833
Alveolar soft part sarcoma 23.87 13.66 8 66262 99 46619693
Streptococcus test positive 23.70 13.66 17 66253 1192 46618600
Angioimmunoblastic T-cell lymphoma 23.58 13.66 8 66262 103 46619689
Small intestinal obstruction 23.57 13.66 63 66207 16109 46603683
Localised infection 23.53 13.66 3 66267 23798 46595994
Throat irritation 23.50 13.66 6 66264 28895 46590897
Influenza 23.43 13.66 58 66212 89212 46530580
Angiocentric lymphoma 23.37 13.66 12 66258 457 46619335
Pulmonary toxicity 23.33 13.66 31 66239 4662 46615130
Encephalitis viral 23.32 13.66 19 66251 1611 46618181
Geotrichum infection 23.30 13.66 12 66258 460 46619332
Partial seizures 23.25 13.66 32 66238 4978 46614814
Fluid retention 23.08 13.66 23 66247 51023 46568769
Blood immunoglobulin G decreased 23.07 13.66 20 66250 1848 46617944
Gastrointestinal necrosis 23.01 13.66 24 66246 2794 46616998
Gastric stenosis 22.98 13.66 7 66263 62 46619730
Staphylococcal infection 22.82 13.66 106 66164 35665 46584127
Gastric disorder 22.79 13.66 5 66265 26700 46593092
Multiple sclerosis 22.50 13.66 4 66266 24787 46595005
Paraplegia 22.49 13.66 22 66248 2372 46617420
Angioedema 22.49 13.66 14 66256 39328 46580464
Hepatic enzyme increased 22.36 13.66 52 66218 81735 46538057
Dysgeusia 22.34 13.66 15 66255 40476 46579316
T-cell type acute leukaemia 22.32 13.66 7 66263 69 46619723
Neutropenic infection 22.31 13.66 16 66254 1122 46618670
Head injury 22.31 13.66 4 66266 24632 46595160
Cytomegalovirus colitis 22.29 13.66 19 66251 1716 46618076
Renal replacement therapy 22.17 13.66 6 66264 33 46619759
Renal vein thrombosis 22.12 13.66 10 66260 286 46619506
Acute lymphocytic leukaemia refractory 22.05 13.66 7 66263 72 46619720
Cytokine release syndrome 22.03 13.66 35 66235 6188 46613604
Visual impairment 22.00 13.66 38 66232 66651 46553141
Premature baby 21.95 13.66 66 66204 18046 46601746
Alveolar rhabdomyosarcoma 21.73 13.66 6 66264 36 46619756
Dry eye 21.59 13.66 8 66262 30314 46589478
Death 21.49 13.66 341 65929 335207 46284585
Necrotising gastritis 21.45 13.66 6 66264 38 46619754
Hepatosplenic candidiasis 21.45 13.66 9 66261 214 46619578
Gait disturbance 21.29 13.66 120 66150 145143 46474649
Chronic myelomonocytic leukaemia 21.25 13.66 10 66260 314 46619478
Autonomic neuropathy 21.17 13.66 13 66257 702 46619090
Skin discolouration 21.05 13.66 10 66260 32670 46587122
Pharyngeal inflammation 21.00 13.66 12 66258 567 46619225
Blood stem cell transplant failure 20.97 13.66 8 66262 147 46619645
Escherichia infection 20.94 13.66 47 66223 10770 46609022
Platelet transfusion 20.94 13.66 13 66257 716 46619076
SARS-CoV-2 test negative 20.93 13.66 7 66263 86 46619706
Confusional state 20.87 13.66 137 66133 159755 46460037
Jejunal stenosis 20.81 13.66 6 66264 43 46619749
Hypoglycaemia 20.79 13.66 28 66242 54321 46565471
Duodenal stenosis 20.75 13.66 12 66258 580 46619212
Epstein Barr virus positive mucocutaneous ulcer 20.74 13.66 9 66261 233 46619559
Haemoglobin abnormal 20.44 13.66 28 66242 4335 46615457
Pneumonia influenzal 20.36 13.66 17 66253 1492 46618300
Dry skin 20.31 13.66 17 66253 40999 46578793
Neutrophil count abnormal 20.24 13.66 21 66249 2429 46617363
Peritonitis viral 20.24 13.66 6 66264 48 46619744
Atypical haemolytic uraemic syndrome 20.11 13.66 11 66259 477 46619315
Abnormal behaviour 20 13.66 3 66267 21055 46598737
Wrong technique in product usage process 19.86 13.66 29 66241 54393 46565399
Parainfluenzae virus infection 19.84 13.66 18 66252 1766 46618026
Blood pressure systolic increased 19.83 13.66 8 66262 28779 46591013
Disturbance in attention 19.81 13.66 10 66260 31550 46588242
Cerebral artery thrombosis 19.76 13.66 10 66260 369 46619423
Serotonin syndrome 19.75 13.66 5 66265 24215 46595577
Mucosal infection 19.72 13.66 7 66263 104 46619688
Coronavirus infection 19.66 13.66 22 66248 2772 46617020
Brain injury 19.62 13.66 33 66237 6117 46613675
Congenital retinoblastoma 19.58 13.66 5 66265 21 46619771
Paranasal sinus mucosal hypertrophy 19.58 13.66 5 66265 21 46619771
Iris atrophy 19.52 13.66 6 66264 55 46619737
Adenovirus infection 19.43 13.66 22 66248 2808 46616984
Leukaemic infiltration 19.39 13.66 5 66265 22 46619770
Central nervous system enteroviral infection 19.39 13.66 5 66265 22 46619770
Respiratory arrest 19.38 13.66 12 66258 33804 46585988
Delayed puberty 19.36 13.66 7 66263 110 46619682
Erythema 19.33 13.66 121 66149 142699 46477093
Balance disorder 19.31 13.66 39 66231 64482 46555310
Listeria encephalitis 19.31 13.66 8 66262 184 46619608
Ocular lymphoma 19.23 13.66 6 66264 58 46619734
Haematocolpos 19.23 13.66 6 66264 58 46619734
Alanine aminotransferase increased 19.18 13.66 201 66069 88250 46531542
Peripheral sensorimotor neuropathy 19.14 13.66 15 66255 1203 46618589
Chronic lymphocytic leukaemia 18.99 13.66 22 66248 2878 46616914
Rectal adenoma 18.88 13.66 6 66264 62 46619730
Chronic obstructive pulmonary disease 18.87 13.66 33 66237 57600 46562192
Oropharyngeal pain 18.83 13.66 49 66221 74119 46545673
Cataract 18.83 13.66 22 66248 45393 46574399
Nervous system disorder 18.82 13.66 58 66212 16071 46603721
Rash pruritic 18.78 13.66 21 66249 44194 46575598
Jugular vein thrombosis 18.75 13.66 21 66249 2649 46617143
Swollen tongue 18.75 13.66 9 66261 29223 46590569
Hepatosplenomegaly 18.74 13.66 20 66250 2390 46617402
Vulvovaginitis 18.72 13.66 9 66261 297 46619495
Tooth disorder 18.64 13.66 5 66265 23298 46596494
Hepatitis acute 18.56 13.66 38 66232 8176 46611616
Acne 18.55 13.66 3 66267 19916 46599876
Primary mediastinal large B-cell lymphoma recurrent 18.54 13.66 6 66264 66 46619726
Meningoencephalitis herpetic 18.52 13.66 14 66256 1064 46618728
Generalised tonic-clonic seizure 18.51 13.66 82 66188 27040 46592752
Vulvovaginal inflammation 18.48 13.66 11 66259 561 46619231
Urinary tract infection bacterial 18.42 13.66 26 66244 4139 46615653
Adverse event 18.41 13.66 13 66257 34171 46585621
Inflammatory myofibroblastic tumour 18.40 13.66 5 66265 28 46619764
Mantle cell lymphoma 18.15 13.66 11 66259 580 46619212
Post lumbar puncture syndrome 18.15 13.66 11 66259 580 46619212
Red blood cell sedimentation rate increased 18.14 13.66 5 66265 22884 46596908
Blood cholesterol increased 18.13 13.66 18 66252 39995 46579797
Foot fracture 18.12 13.66 3 66267 19579 46600213
Underdose 18.09 13.66 3 66267 19555 46600237
Escherichia sepsis 18.08 13.66 26 66244 4212 46615580
Blood bilirubin increased 18.04 13.66 96 66174 34088 46585704
Limb discomfort 18.00 13.66 5 66265 22771 46597021
Graft versus host disease 17.97 13.66 33 66237 6555 46613237
Coronary artery disease 17.96 13.66 13 66257 33739 46586053
Salivary gland cancer 17.94 13.66 7 66263 137 46619655
Skin ulcer 17.94 13.66 12 66258 32446 46587346
Retinal pigment epitheliopathy 17.92 13.66 8 66262 222 46619570
Candida sepsis 17.89 13.66 15 66255 1324 46618468
Bacillus infection 17.89 13.66 9 66261 328 46619464
Cardiopulmonary failure 17.88 13.66 24 66246 3645 46616147
Acute leukaemia 17.85 13.66 14 66256 1124 46618668
Acute monocytic leukaemia 17.84 13.66 6 66264 75 46619717
Restlessness 17.73 13.66 7 66263 25517 46594275
Oedema due to cardiac disease 17.70 13.66 5 66265 33 46619759
Intracardiac thrombus 17.68 13.66 19 66251 2289 46617503
Urethritis 17.66 13.66 8 66262 230 46619562
Joint injury 17.65 13.66 3 66267 19206 46600586
Lower respiratory tract infection 17.62 13.66 32 66238 55057 46564735
Amnesia 17.44 13.66 20 66250 41611 46578181
Myeloproliferative neoplasm 17.33 13.66 10 66260 481 46619311
Haematoma 17.33 13.66 12 66258 31860 46587932
Primary cardiac lymphoma 17.33 13.66 5 66265 36 46619756
Blood magnesium decreased 17.23 13.66 44 66226 10948 46608844
Precursor T-lymphoblastic lymphoma/leukaemia 17.21 13.66 5 66265 37 46619755
Splenic necrosis 17.21 13.66 5 66265 37 46619755
Axonal neuropathy 17.19 13.66 13 66257 989 46618803
Chronic hepatitis B 17.13 13.66 8 66262 247 46619545
Bacillus test positive 17.09 13.66 5 66265 38 46619754
Blast crisis in myelogenous leukaemia 17.02 13.66 10 66260 498 46619294
Cauda equina syndrome 16.99 13.66 11 66259 652 46619140
Flagellate dermatitis 16.98 13.66 7 66263 159 46619633
Heart rate irregular 16.87 13.66 3 66267 18588 46601204
Enteral nutrition 16.87 13.66 5 66265 40 46619752
Chromosomal deletion 16.87 13.66 5 66265 40 46619752
Swelling face 16.81 13.66 31 66239 53028 46566764
Acidosis 16.76 13.66 44 66226 11130 46608662
Haemangioma-thrombocytopenia syndrome 16.68 13.66 3 66267 0 46619792
Bone marrow leukaemic cell infiltration 16.68 13.66 3 66267 0 46619792
Antithrombin III deficiency 16.68 13.66 3 66267 0 46619792
Central nervous system leukaemia 16.67 13.66 6 66264 93 46619699
Diffuse large B-cell lymphoma stage III 16.65 13.66 5 66265 42 46619750
Hyperkalaemia 16.63 13.66 29 66241 50680 46569112
Hypophosphataemia 16.55 13.66 34 66236 7333 46612459
Device issue 16.53 13.66 4 66266 19976 46599816
Lymphocytosis 16.43 13.66 18 66252 2216 46617576
Rectal fissure 16.42 13.66 10 66260 532 46619260
Hepatic function abnormal 16.38 13.66 94 66176 34327 46585465
Cardiac disorder 16.37 13.66 23 66247 43835 46575957
Aborted pregnancy 16.35 13.66 5 66265 45 46619747
Withdrawal syndrome 16.30 13.66 3 66267 18131 46601661
Nephropathy toxic 16.27 13.66 34 66236 7420 46612372
Lipase increased 16.23 13.66 37 66233 8566 46611226
Tachypnoea 16.18 13.66 51 66219 14300 46605492
Quadriparesis 16.18 13.66 16 66254 1748 46618044
Endocarditis 16.13 13.66 27 66243 4985 46614807
Encopresis 16.10 13.66 6 66264 103 46619689
Pancreatitis acute 16.08 13.66 74 66196 24798 46594994
Blister 16.07 13.66 24 66246 44607 46575185
Meningitis coccidioides 16.02 13.66 4 66266 15 46619777
Vertigo 15.97 13.66 31 66239 52017 46567775
B-lymphocyte count abnormal 15.97 13.66 5 66265 49 46619743
Therapy cessation 15.89 13.66 9 66261 26620 46593172
Beta 2 microglobulin decreased 15.82 13.66 4 66266 16 46619776
Pancreatic pseudocyst 15.81 13.66 10 66260 569 46619223
Intra-abdominal haemorrhage 15.81 13.66 18 66252 2312 46617480
Neuroblastoma 15.79 13.66 5 66265 51 46619741
Hyperviscosity syndrome 15.79 13.66 7 66263 191 46619601
Enterocolitis 15.71 13.66 30 66240 6138 46613654
Refractory cytopenia with unilineage dysplasia 15.68 13.66 10 66260 577 46619215
Fear of injection 15.62 13.66 24 66246 4123 46615669
Intestinal dilatation 15.57 13.66 15 66255 1587 46618205
Vascular compression 15.54 13.66 6 66264 114 46619678
Gastroenteritis salmonella 15.52 13.66 9 66261 437 46619355
Cranial nerve disorder 15.52 13.66 8 66262 307 46619485
Respiratory syncytial virus infection 15.50 13.66 26 66244 4809 46614983
Abdominal compartment syndrome 15.47 13.66 10 66260 591 46619201
Osteoporosis 15.45 13.66 21 66249 40587 46579205
Anal ulcer 15.45 13.66 9 66261 441 46619351
Anal injury 15.44 13.66 4 66266 18 46619774
Hypoaesthesia 15.43 13.66 102 66168 118767 46501025
Haemoglobin decreased 15.41 13.66 263 66007 128686 46491106
Myelitis 15.41 13.66 13 66257 1157 46618635
Splenomegaly 15.41 13.66 39 66231 9649 46610143
Interstitial lung disease 15.40 13.66 130 66140 53819 46565973
Pulmonary vascular disorder 15.31 13.66 8 66262 316 46619476
Staphylococcus test positive 15.30 13.66 22 66248 3562 46616230
Viral haemorrhagic cystitis 15.29 13.66 10 66260 603 46619189
Treatment failure 15.26 13.66 74 66196 93013 46526779
Hepatitis B surface antigen positive 15.21 13.66 5 66265 58 46619734
Subileus 15.18 13.66 20 66250 2983 46616809
Postictal state 15.13 13.66 12 66258 979 46618813
Malignant neoplasm of orbit 15.10 13.66 4 66266 20 46619772
Malnutrition 15.09 13.66 49 66221 13954 46605838
Brain herniation 15.08 13.66 20 66250 3003 46616789
Klebsiella test positive 15.07 13.66 12 66258 985 46618807
Hyporeflexia 15.03 13.66 16 66254 1906 46617886
Impaired healing 15.02 13.66 18 66252 36725 46583067
Porphyria non-acute 15.01 13.66 8 66262 329 46619463
Cardiac failure congestive 15.00 13.66 73 66197 91677 46528115
Adult T-cell lymphoma/leukaemia 14.90 13.66 8 66262 334 46619458
Ear infection 14.89 13.66 7 66263 23006 46596786
Diffuse large B-cell lymphoma stage IV 14.87 13.66 7 66263 220 46619572
Liver function test abnormal 14.87 13.66 27 66243 46460 46573332
Acute graft versus host disease 14.73 13.66 23 66247 4007 46615785
Laboratory test abnormal 14.70 13.66 7 66263 22840 46596952
Asthenia 14.69 13.66 333 65937 310742 46309050
Enterococcus test positive 14.61 13.66 12 66258 1029 46618763
Adenoviral haemorrhagic cystitis 14.60 13.66 6 66264 135 46619657
Ventriculo-peritoneal shunt 14.60 13.66 3 66267 3 46619789
Pancreatic infarction 14.60 13.66 3 66267 3 46619789
Vaginal obstruction 14.60 13.66 3 66267 3 46619789
Vulvovaginal adhesion 14.60 13.66 3 66267 3 46619789
Periorbital cellulitis 14.57 13.66 9 66261 491 46619301
Cardiac dysfunction 14.57 13.66 14 66256 1477 46618315
Febrile infection 14.55 13.66 13 66257 1250 46618542
Sopor 14.51 13.66 5 66265 19823 46599969
Cheyne-Stokes respiration 14.44 13.66 6 66264 139 46619653
Pyloric stenosis 14.42 13.66 8 66262 357 46619435
Eye irritation 14.40 13.66 3 66267 16611 46603181
Heart rate increased 14.36 13.66 56 66214 74735 46545057
Pseudomonal bacteraemia 14.30 13.66 13 66257 1278 46618514
Sarcoidosis 14.27 13.66 26 66244 5133 46614659
Osteosarcoma 14.25 13.66 6 66264 144 46619648
Encephalitis cytomegalovirus 14.22 13.66 9 66261 513 46619279
Campylobacter infection 14.15 13.66 10 66260 685 46619107
Myocardial oedema 14.10 13.66 5 66265 74 46619718
Graft versus host disease in skin 13.92 13.66 17 66253 2350 46617442
Liver abscess 13.89 13.66 18 66252 2641 46617151
Granulocytopenia 13.86 13.66 26 66244 5247 46614545
Rash macular 13.85 13.66 5 66265 19255 46600537
Cancer in remission 13.84 13.66 4 66266 29 46619763
Psychiatric decompensation 13.82 13.66 12 66258 1111 46618681
Eosinophilia 13.80 13.66 5 66265 19212 46600580
Electrocardiogram QT prolonged 13.73 13.66 33 66237 51292 46568500
Perirectal abscess 13.73 13.66 11 66259 911 46618881
Fungal test positive 13.67 13.66 9 66261 549 46619243

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 3674.21 12.79 2780 83889 103913 29761896
Neutropenia 1395.08 12.79 1783 84886 126757 29739052
Hepatitis B 685.51 12.79 340 86329 5732 29860077
Product use in unapproved indication 650.00 12.79 926 85743 72767 29793042
Mucosal inflammation 645.68 12.79 603 86066 29891 29835918
Febrile bone marrow aplasia 572.16 12.79 332 86337 7765 29858044
Second primary malignancy 562.02 12.79 302 86367 6054 29859755
Bone marrow failure 525.48 12.79 533 86136 29252 29836557
Diffuse large B-cell lymphoma recurrent 464.18 12.79 188 86481 1904 29863905
Myelodysplastic syndrome 455.55 12.79 401 86268 18377 29847432
Diffuse large B-cell lymphoma 421.72 12.79 270 86399 7571 29858238
Pancytopenia 418.57 12.79 823 85846 84229 29781580
Haematotoxicity 412.21 12.79 244 86425 5926 29859883
Venoocclusive liver disease 411.93 12.79 250 86419 6363 29859446
Tumour lysis syndrome 384.30 12.79 310 86359 12575 29853234
Posterior reversible encephalopathy syndrome 377.05 12.79 262 86407 8445 29857364
Acute myeloid leukaemia 376.93 12.79 354 86315 17652 29848157
Hepatitis B reactivation 351.29 12.79 170 86499 2707 29863102
Hypofibrinogenaemia 328.15 12.79 137 86532 1508 29864301
Myelosuppression 295.38 12.79 211 86458 7111 29858698
Pyrexia 284.86 12.79 1633 85036 292856 29572953
Progressive multifocal leukoencephalopathy 281.87 12.79 223 86446 8790 29857019
Off label use 277.02 12.79 1436 85233 247854 29617955
Leukopenia 268.20 12.79 537 86132 55622 29810187
Fall 257.94 12.79 102 86567 181770 29684039
Acute lymphocytic leukaemia 243.97 12.79 136 86533 2936 29862873
Thrombocytopenia 241.47 12.79 907 85762 136137 29729672
Pneumocystis jirovecii pneumonia 241.06 12.79 272 86397 16848 29848961
Sepsis 229.61 12.79 934 85735 145461 29720348
Neuropathy peripheral 221.63 12.79 571 86098 69904 29795905
Cytomegalovirus chorioretinitis 220.25 12.79 130 86539 3138 29862671
Acute lymphocytic leukaemia recurrent 219.83 12.79 121 86548 2546 29863263
Product dose omission issue 219.51 12.79 11 86658 91620 29774189
Neoplasm progression 213.33 12.79 262 86407 17761 29848048
Neutrophil count decreased 208.68 12.79 411 86258 42043 29823766
Death 198.37 12.79 466 86203 356817 29508992
Septic shock 194.46 12.79 510 86159 63097 29802712
Neutropenic sepsis 189.86 12.79 198 86471 11211 29854598
Diffuse large B-cell lymphoma refractory 186.83 12.79 74 86595 703 29865106
Myocardial infarction 182.02 12.79 68 86601 125557 29740252
Acquired gene mutation 173.85 12.79 79 86590 1082 29864727
B-cell lymphoma recurrent 171.42 12.79 66 86603 577 29865232
Dizziness 169.17 12.79 189 86480 194720 29671089
Cytopenia 168.28 12.79 160 86509 8096 29857713
Arthralgia 167.88 12.79 92 86577 135699 29730110
Fatigue 167.06 12.79 432 86237 320241 29545568
Rash 160.12 12.79 192 86477 191697 29674112
Disease progression 156.81 12.79 548 86121 79326 29786483
Post transplant lymphoproliferative disorder 152.55 12.79 125 86544 5181 29860628
Hypertriglyceridaemia 148.30 12.79 148 86521 7950 29857859
Cardiotoxicity 146.18 12.79 113 86556 4301 29861508
Hyperbilirubinaemia 146.15 12.79 211 86458 16731 29849078
White blood cell count decreased 140.48 12.79 547 86122 83400 29782409
Hypogammaglobulinaemia 135.03 12.79 116 86553 5136 29860673
Pain 134.37 12.79 182 86487 172459 29693350
Mantle cell lymphoma recurrent 133.03 12.79 49 86620 374 29865435
Neoplasm recurrence 133.02 12.79 77 86592 1790 29864019
Leukoencephalopathy 131.55 12.79 102 86567 3900 29861909
Muscle spasms 129.96 12.79 17 86652 64821 29800988
Neurotoxicity 129.86 12.79 175 86494 13007 29852802
Dyspnoea 129.41 12.79 512 86157 332783 29533026
Insomnia 127.82 12.79 55 86614 93281 29772528
Anxiety 122.99 12.79 53 86616 89818 29775991
Rhabdomyolysis 121.99 12.79 19 86650 63561 29802248
Overdose 121.50 12.79 46 86623 84291 29781518
Aspergillus infection 118.45 12.79 147 86522 10067 29855742
Joint swelling 117.84 12.79 4 86665 46942 29818867
Peripheral swelling 115.49 12.79 19 86650 61055 29804754
Malaise 111.68 12.79 195 86474 166767 29699042
Lymphopenia 110.70 12.79 162 86507 13001 29852808
Depression 109.20 12.79 63 86606 90374 29775435
Polyneuropathy 108.98 12.79 152 86517 11671 29854138
Pruritus 108.70 12.79 109 86560 118095 29747714
Osteonecrosis 108.35 12.79 179 86490 15956 29849853
Epstein-Barr virus infection 107.32 12.79 114 86555 6592 29859217
Bacteraemia 106.35 12.79 174 86495 15386 29850423
Lymphadenopathy 105.52 12.79 224 86445 24152 29841657
Hepatic failure 102.95 12.79 272 86397 33771 29832038
Malignant neoplasm progression 102.72 12.79 448 86221 71839 29793970
Rheumatoid arthritis 101.70 12.79 4 86665 41193 29824616
Central nervous system lymphoma 101.43 12.79 50 86619 830 29864979
Myelopathy 97.18 12.79 64 86605 1883 29863926
Venoocclusive disease 93.92 12.79 70 86599 2520 29863289
Disease recurrence 93.61 12.79 156 86513 14005 29851804
Weight increased 93.59 12.79 50 86619 74863 29790946
Myalgia 93.13 12.79 53 86616 76614 29789195
Coronary artery disease 92.80 12.79 16 86653 49696 29816113
Cerebrovascular accident 92.72 12.79 64 86605 83413 29782396
Feeling abnormal 92.28 12.79 25 86644 56731 29809078
Stomatitis 92.27 12.79 277 86392 37002 29828807
Therapy partial responder 91.80 12.79 80 86589 3611 29862198
Aplasia 91.46 12.79 83 86586 3954 29861855
Suicidal ideation 90.91 12.79 3 86666 36111 29829698
Sweat gland tumour 90.02 12.79 37 86632 390 29865419
Suicide attempt 89.13 12.79 4 86665 36693 29829116
Cardiac failure congestive 88.20 12.79 69 86600 84338 29781471
Candida infection 86.90 12.79 158 86511 15204 29850605
Somnolence 85.80 12.79 92 86577 96671 29769138
Inappropriate schedule of product administration 85.70 12.79 8 86661 39720 29826089
B-cell lymphoma 85.49 12.79 84 86585 4426 29861383
Hallucination 84.83 12.79 19 86650 49040 29816769
Ileus paralytic 83.35 12.79 92 86577 5556 29860253
Psoriasis 83.14 12.79 12 86657 42494 29823315
Blood fibrinogen decreased 81.86 12.79 45 86624 944 29864865
Cytomegalovirus infection 81.82 12.79 199 86470 23475 29842334
Hospitalisation 81.13 12.79 15 86654 44304 29821505
Herpes simplex 80.65 12.79 81 86588 4383 29861426
Platelet count decreased 77.96 12.79 550 86119 105579 29760230
Intentional product misuse 77.46 12.79 6 86663 34661 29831148
Nasopharyngitis 76.90 12.79 37 86632 58812 29806997
Infection 76.18 12.79 435 86234 77639 29788170
Drug resistance 73.63 12.79 173 86496 19960 29845849
Colitis 73.44 12.79 226 86443 30594 29835215
Cytokine release syndrome 73.24 12.79 115 86554 9818 29855991
Chronic obstructive pulmonary disease 71.88 12.79 22 86647 46104 29819705
Multiple organ dysfunction syndrome 70.18 12.79 366 86303 63121 29802688
Chest pain 69.32 12.79 148 86521 117479 29748330
Bronchopulmonary aspergillosis 69.05 12.79 126 86543 12158 29853651
Aggression 68.61 12.79 12 86657 36895 29828914
Blood glucose increased 68.54 12.79 47 86622 61483 29804326
Cerebral venous thrombosis 68.51 12.79 34 86635 573 29865236
Blood creatine phosphokinase increased 68.17 12.79 21 86648 43827 29821982
Drug interaction 67.76 12.79 322 86347 199246 29666563
Adenovirus infection 67.31 12.79 72 86597 4196 29861613
Neutropenic colitis 67.19 12.79 54 86615 2176 29863633
Hyperhidrosis 66.17 12.79 58 86611 67032 29798777
West Nile viral infection 65.87 12.79 33 86636 568 29865241
Diarrhoea 65.49 12.79 635 86034 333468 29532341
Cytogenetic abnormality 65.37 12.79 36 86633 758 29865051
Tremor 65.30 12.79 73 86596 75290 29790519
Haemophagocytic lymphohistiocytosis 63.56 12.79 107 86562 9684 29856125
Confusional state 62.96 12.79 191 86478 134643 29731166
Lymphoma 62.27 12.79 108 86561 10013 29855796
Blood culture positive 62.24 12.79 74 86595 4845 29860964
Bacterial sepsis 62.16 12.79 74 86595 4852 29860957
Adenoviral hepatitis 61.85 12.79 22 86647 150 29865659
Mucormycosis 61.37 12.79 76 86593 5192 29860617
Epstein-Barr virus associated lymphoproliferative disorder 61.09 12.79 46 86623 1682 29864127
Blood pressure increased 60.88 12.79 71 86598 71857 29793952
Asthma 60.58 12.79 15 86654 36159 29829650
Escherichia sepsis 60.57 12.79 66 86603 3928 29861881
Oesophageal stenosis 60.13 12.79 44 86625 1539 29864270
Agranulocytosis 60.01 12.79 169 86500 21773 29844036
Superior sagittal sinus thrombosis 58.94 12.79 25 86644 287 29865522
Acute lymphocytic leukaemia refractory 57.86 12.79 19 86650 98 29865711
Fungal infection 57.71 12.79 124 86545 13476 29852333
Stem cell transplant 56.68 12.79 48 86621 2083 29863726
Antithrombin III decreased 56.45 12.79 26 86643 368 29865441
Systemic mycosis 55.95 12.79 38 86631 1178 29864631
Gastritis bacterial 55.94 12.79 21 86648 170 29865639
Hepatotoxicity 55.87 12.79 146 86523 17999 29847810
Memory impairment 55.67 12.79 19 86650 37155 29828654
Staphylococcal sepsis 55.44 12.79 99 86570 9392 29856417
Incorrect dose administered 55.32 12.79 12 86657 31674 29834135
Malignant transformation 55.07 12.79 31 86638 682 29865127
Injection site pain 53.90 12.79 11 86658 30299 29835510
Asthenia 53.88 12.79 397 86272 220893 29644916
Oedema peripheral 53.73 12.79 144 86525 105688 29760121
Coombs positive haemolytic anaemia 53.04 12.79 31 86638 734 29865075
Headache 52.99 12.79 310 86359 181996 29683813
Hypoglycaemia 52.82 12.79 42 86627 50939 29814870
Plasmablastic lymphoma 52.22 12.79 22 86647 248 29865561
Leukaemia recurrent 51.77 12.79 40 86629 1521 29864288
Pain in extremity 51.53 12.79 156 86513 110065 29755744
Inappropriate antidiuretic hormone secretion 50.62 12.79 106 86563 11316 29854493
Gait disturbance 49.30 12.79 88 86581 74689 29791120
Chest discomfort 48.99 12.79 36 86633 45444 29820365
Pseudomonas infection 48.47 12.79 99 86570 10383 29855426
Back pain 48.10 12.79 145 86524 102451 29763358
Loss of consciousness 47.46 12.79 99 86570 79276 29786533
Strongyloidiasis 46.91 12.79 45 86624 2301 29863508
Aspiration bone marrow abnormal 46.86 12.79 16 86653 95 29865714
Stress 46.66 12.79 3 86666 20232 29845577
Drug hypersensitivity 46.65 12.79 79 86590 68440 29797369
Hepatosplenic candidiasis 46.42 12.79 19 86650 198 29865611
Cerebral venous sinus thrombosis 46.18 12.79 21 86648 288 29865521
Pneumonitis 45.92 12.79 179 86490 27275 29838534
Pulmonary vascular disorder 45.63 12.79 22 86647 347 29865462
Peripheral motor neuropathy 45.42 12.79 38 86631 1621 29864188
Myelitis transverse 45.42 12.79 31 86638 969 29864840
Intussusception 45.41 12.79 25 86644 526 29865283
Injury 45.24 12.79 5 86664 21726 29844083
Arthropathy 45.16 12.79 4 86665 20723 29845086
Gastrointestinal toxicity 44.93 12.79 41 86628 1967 29863842
JC virus infection 44.92 12.79 39 86630 1751 29864058
Cystitis haemorrhagic 44.79 12.79 62 86607 4725 29861084
Abdominal discomfort 44.78 12.79 45 86624 48746 29817063
Musculoskeletal stiffness 44.71 12.79 24 86645 35857 29829952
Device related infection 44.53 12.79 129 86540 16886 29848923
Syncope 42.72 12.79 116 86553 84787 29781022
Glioma 42.44 12.79 20 86649 299 29865510
Bone marrow necrosis 42.36 12.79 16 86653 132 29865677
Pleural effusion 42.20 12.79 362 86307 73704 29792105
Hepatomegaly 41.93 12.79 91 86578 9956 29855853
Balance disorder 41.81 12.79 27 86642 36466 29829343
Respiratory failure 41.68 12.79 460 86209 100182 29765627
Wrong technique in product usage process 41.59 12.79 19 86650 31136 29834673
Hyperkalaemia 41.45 12.79 80 86589 65930 29799879
Therapy non-responder 41.37 12.79 182 86487 29271 29836538
Anaemia 41.23 12.79 837 85832 207155 29658654
Enterovirus infection 41.22 12.79 24 86645 564 29865245
Nausea 40.97 12.79 609 86060 296348 29569461
Peripheral T-cell lymphoma unspecified 40.94 12.79 23 86646 504 29865305
Recurrent cancer 40.90 12.79 31 86638 1145 29864664
Cardiomyopathy 40.78 12.79 116 86553 15027 29850782
Lung infiltration 40.67 12.79 103 86566 12456 29853353
Lymphadenitis 40.22 12.79 36 86633 1684 29864125
Loss of personal independence in daily activities 40.03 12.79 7 86662 21528 29844281
Product quality issue 39.90 12.79 4 86665 18770 29847039
Viral haemorrhagic cystitis 39.84 12.79 27 86642 834 29864975
Central nervous system leukaemia 39.64 12.79 18 86651 246 29865563
Systemic candida 39.03 12.79 44 86625 2720 29863089
Primitive neuroectodermal tumour 38.68 12.79 13 86656 73 29865736
Unevaluable event 38.53 12.79 22 86647 31763 29834046
Refractory anaemia with an excess of blasts 38.34 12.79 20 86649 376 29865433
Congenital cardiovascular anomaly 38.08 12.79 16 86653 179 29865630
Coagulopathy 38.08 12.79 129 86540 18358 29847451
Ejection fraction decreased 37.75 12.79 113 86556 15062 29850747
Sleep disorder 37.55 12.79 12 86657 24467 29841342
Serotonin syndrome 37.54 12.79 4 86665 17887 29847922
Encephalitis enteroviral 37.28 12.79 15 86654 149 29865660
Cardio-respiratory arrest 37.26 12.79 68 86601 57238 29808571
Lymphoma transformation 36.84 12.79 15 86654 154 29865655
International normalised ratio increased 36.36 12.79 51 86618 47688 29818121
Peripheral sensory neuropathy 36.34 12.79 63 86606 5838 29859971
Haemoglobin abnormal 36.22 12.79 45 86624 3084 29862725
Sedation 36.11 12.79 3 86666 16370 29849439
Mobility decreased 36.06 12.79 15 86654 25984 29839825
Treatment noncompliance 35.96 12.79 14 86655 25239 29840570
Neuroleptic malignant syndrome 35.90 12.79 3 86666 16292 29849517
Weight decreased 35.61 12.79 273 86396 150648 29715161
Chronic lymphocytic leukaemia refractory 35.55 12.79 13 86656 97 29865712
Haemolysis 35.47 12.79 70 86599 7161 29858648
Fluid retention 35.36 12.79 14 86655 24984 29840825
Depressed mood 35.24 12.79 4 86665 17025 29848784
Pneumocystis jirovecii infection 35.17 12.79 30 86639 1315 29864494
Acute myelomonocytic leukaemia 34.98 12.79 14 86655 137 29865672
Nephrolithiasis 34.92 12.79 14 86655 24796 29841013
T-cell type acute leukaemia 34.92 12.79 15 86654 178 29865631
Minimal residual disease 34.89 12.79 16 86653 224 29865585
Epstein-Barr virus associated lymphoma 34.77 12.79 21 86648 529 29865280
Contusion 34.68 12.79 24 86645 31256 29834553
Pulmonary toxicity 34.29 12.79 53 86616 4463 29861346
Blood stem cell transplant failure 34.25 12.79 19 86650 406 29865403
Klebsiella infection 34.18 12.79 67 86602 6820 29858989
Toxicity to various agents 34.05 12.79 338 86331 176845 29688964
Escherichia bacteraemia 34.02 12.79 42 86627 2860 29862949
Wheezing 33.95 12.79 24 86645 30914 29834895
Gene mutation 33.89 12.79 24 86645 797 29865012
Escherichia infection 33.86 12.79 64 86605 6341 29859468
B-cell lymphoma refractory 33.83 12.79 13 86656 113 29865696
Body height below normal 33.79 12.79 16 86653 242 29865567
Abnormal behaviour 33.63 12.79 16 86653 25607 29840202
Atrial fibrillation 33.46 12.79 180 86489 107944 29757865
Bradycardia 33.35 12.79 89 86580 65437 29800372
Abdominal pain upper 33.34 12.79 83 86586 62468 29803341
Adverse event 33.32 12.79 3 86666 15338 29850471
Nervous system disorder 33.16 12.79 98 86571 12971 29852838
End stage renal disease 32.94 12.79 69 86600 7366 29858443
Electrocardiogram QT prolonged 32.94 12.79 33 86636 35802 29830007
Rhabdomyosarcoma recurrent 32.87 12.79 12 86657 89 29865720
Agitation 32.69 12.79 67 86602 54006 29811803
Xanthogranuloma 32.50 12.79 10 86659 40 29865769
Juvenile melanoma benign 32.40 12.79 11 86658 64 29865745
Respiratory distress 32.30 12.79 184 86485 32788 29833021
Pneumonia aspiration 32.27 12.79 37 86632 37743 29828066
Neuroblastoma 32.15 12.79 15 86654 219 29865590
Pulmonary arteriopathy 32.12 12.79 11 86658 66 29865743
Intestinal perforation 32.01 12.79 74 86595 8445 29857364
Palpitations 31.92 12.79 30 86639 33543 29832266
Cardiac arrest 31.91 12.79 149 86520 92701 29773108
Blood pressure fluctuation 31.86 12.79 6 86663 17497 29848312
Hepatosplenomegaly 31.76 12.79 46 86623 3655 29862154
Pneumatosis intestinalis 31.64 12.79 39 86630 2651 29863158
Epstein-Barr viraemia 31.53 12.79 24 86645 892 29864917
Hereditary motor and sensory neuropathy 31.49 12.79 8 86661 12 29865797
Influenza 31.45 12.79 48 86621 43350 29822459
Drug reaction with eosinophilia and systemic symptoms 31.39 12.79 22 86647 28466 29837343
Acute promyelocytic leukaemia 31.37 12.79 20 86649 556 29865253
Ganglioneuroblastoma 31.24 12.79 9 86660 27 29865782
Clostridium test positive 31.22 12.79 34 86635 2022 29863787
Adverse drug reaction 31.08 12.79 14 86655 23131 29842678
Dry skin 31.07 12.79 13 86656 22441 29843368
Acute monocytic leukaemia 31.03 12.79 17 86652 354 29865455
T-cell lymphoma 30.82 12.79 24 86645 923 29864886
Infection reactivation 30.71 12.79 24 86645 928 29864881
Amnesia 30.69 12.79 16 86653 24305 29841504
Hepatic infection fungal 30.43 12.79 13 86656 152 29865657
Disseminated intravascular coagulation 30.37 12.79 136 86533 22035 29843774
Neurofibrosarcoma 30.30 12.79 9 86660 31 29865778
Autoimmune lymphoproliferative syndrome 30.28 12.79 13 86656 154 29865655
Chronic kidney disease 30.26 12.79 39 86630 37799 29828010
Staphylococcal bacteraemia 30.21 12.79 63 86606 6705 29859104
Subdural hygroma 29.88 12.79 16 86653 318 29865491
Human rhinovirus test positive 29.77 12.79 13 86656 161 29865648
Mantle cell lymphoma 29.76 12.79 29 86640 1512 29864297
Delayed puberty 29.42 12.79 13 86656 166 29865643
Acute hepatic failure 29.35 12.79 88 86581 11739 29854070
Transformation to acute myeloid leukaemia 29.28 12.79 20 86649 626 29865183
Injection site erythema 29.26 12.79 3 86666 13831 29851978
Small intestinal perforation 29.18 12.79 30 86639 1669 29864140
Anal inflammation 29.09 12.79 16 86653 336 29865473
Hepatocellular injury 28.92 12.79 148 86521 25323 29840486
Multiple-drug resistance 28.89 12.79 39 86630 2902 29862907
Pneumonia viral 28.61 12.79 37 86632 2640 29863169
Plasma cell myeloma 28.44 12.79 71 86598 53391 29812418
Transient ischaemic attack 28.38 12.79 19 86650 25181 29840628
Pseudomonal sepsis 28.28 12.79 39 86630 2961 29862848
Cerebral thrombosis 28.23 12.79 22 86647 847 29864962
Traumatic lung injury 28.17 12.79 25 86644 1156 29864653
Bone marrow infiltration 28.10 12.79 11 86658 101 29865708
Stevens-Johnson syndrome 28.02 12.79 8 86661 17548 29848261
Left ventricular dysfunction 27.85 12.79 71 86598 8620 29857189
Hypersensitivity 27.78 12.79 73 86596 53955 29811854
Blood creatinine increased 27.78 12.79 153 86516 91222 29774587
Decreased appetite 27.53 12.79 289 86380 149621 29716188
Myocardial ischaemia 27.44 12.79 8 86661 17309 29848500
High-grade B-cell lymphoma 27.10 12.79 12 86657 154 29865655
Ewing's sarcoma 26.83 12.79 8 86661 28 29865781
Optic glioma 26.83 12.79 8 86661 28 29865781
Intestinal pseudo-obstruction 26.82 12.79 24 86645 1122 29864687
Hot flush 26.79 12.79 5 86664 14675 29851134
Musculoskeletal pain 26.75 12.79 30 86639 30910 29834899
Encephalopathy 26.64 12.79 172 86497 32033 29833776
Haematochezia 26.62 12.79 36 86633 34186 29831623
Gastrosplenic fistula 26.62 12.79 8 86661 29 29865780
Cardiac disorder 26.23 12.79 47 86622 39846 29825963
Gastrooesophageal reflux disease 26.04 12.79 33 86636 32222 29833587
Diffuse large B-cell lymphoma stage IV 25.88 12.79 13 86656 225 29865584
Herpes simplex encephalitis 25.80 12.79 14 86655 286 29865523
Ascites 25.64 12.79 185 86484 35736 29830073
Acute lung injury 25.55 12.79 23 86646 1084 29864725
Lymphocytosis 25.52 12.79 30 86639 1940 29863869
Rhabdomyosarcoma 25.48 12.79 9 86660 60 29865749
Diffuse large B-cell lymphoma stage III 25.48 12.79 9 86660 60 29865749
Chronic lymphocytic leukaemia 25.41 12.79 47 86622 4581 29861228
Clostridium difficile colitis 25.34 12.79 88 86581 12680 29853129
Bone marrow disorder 25.33 12.79 26 86643 1444 29864365
Device related thrombosis 25.25 12.79 20 86649 789 29865020
Vision blurred 25.11 12.79 52 86617 41764 29824045
Dysgeusia 24.97 12.79 21 86648 24780 29841029
Blood glucose decreased 24.80 12.79 4 86665 13049 29852760
Heart rate decreased 24.78 12.79 15 86654 20979 29844830
Varicella zoster virus infection 24.75 12.79 24 86645 1244 29864565
Thymus enlargement 24.74 12.79 9 86660 66 29865743
Oesophageal candidiasis 24.69 12.79 44 86625 4166 29861643
Pneumoperitoneum 24.69 12.79 27 86642 1613 29864196
Sleep apnoea syndrome 24.58 12.79 9 86660 16848 29848961
Medulloblastoma recurrent 24.51 12.79 9 86660 68 29865741
Prostatic specific antigen increased 24.39 12.79 3 86666 12001 29853808
Delusion 24.35 12.79 3 86666 11986 29853823
Pneumonia fungal 24.11 12.79 51 86618 5482 29860327
Intestinal atresia 24.07 12.79 9 86660 72 29865737
Therapy cessation 23.97 12.79 7 86662 15130 29850679
Rib fracture 23.94 12.79 4 86665 12716 29853093
Azoospermia 23.85 12.79 15 86654 407 29865402
Hepatic candidiasis 23.64 12.79 8 86661 46 29865763
Metastases to bone marrow 23.64 12.79 16 86653 493 29865316
Liver function test abnormal 23.63 12.79 33 86636 30917 29834892
BK virus infection 23.56 12.79 44 86625 4320 29861489
Interstitial lung disease 23.47 12.79 272 86397 59925 29805884
Cerebral aspergillosis 23.36 12.79 24 86645 1334 29864475
Delirium 23.17 12.79 52 86617 40579 29825230
Influenza like illness 23.05 12.79 24 86645 25581 29840228
Vertigo 23.00 12.79 19 86650 22616 29843193
Neutropenic infection 22.98 12.79 21 86648 1009 29864800
Flushing 22.96 12.79 31 86638 29461 29836348
Refractory cancer 22.96 12.79 10 86659 123 29865686
Congenital herpes simplex infection 22.95 12.79 8 86661 51 29865758
Faeces discoloured 22.93 12.79 6 86663 13940 29851869
Mucosal infection 22.80 12.79 12 86657 230 29865579
Ameloblastoma 22.77 12.79 9 86660 85 29865724
Alanine aminotransferase increased 22.76 12.79 321 86348 73955 29791854
Gastrointestinal necrosis 22.76 12.79 37 86632 3252 29862557
Cellulitis gangrenous 22.67 12.79 11 86658 176 29865633
Blastic plasmacytoid dendritic cell neoplasia 22.67 12.79 9 86660 86 29865723
Blindness cortical 22.62 12.79 13 86656 298 29865511
Splenic lesion 22.54 12.79 10 86659 129 29865680
Clostridium difficile infection 22.51 12.79 98 86571 15685 29850124
Enterocolitis infectious 22.50 12.79 22 86647 1152 29864657
Osteosarcoma 22.18 12.79 11 86658 185 29865624
Blood pressure systolic increased 22.14 12.79 8 86661 15102 29850707
Gallbladder oedema 22.08 12.79 11 86658 187 29865622
Burning sensation 22.06 12.79 10 86659 16464 29849345
Respiratory tract infection fungal 22.01 12.79 17 86652 646 29865163
Psoriatic arthropathy 22.01 12.79 9 86660 15752 29850057
Renal salt-wasting syndrome 22 12.79 10 86659 137 29865672
Psychotic disorder 21.93 12.79 18 86651 21497 29844312
Stomatococcal infection 21.87 12.79 10 86659 139 29865670
Morphoea 21.74 12.79 10 86659 141 29865668
Ileus 21.74 12.79 96 86573 15459 29850350
Restlessness 21.71 12.79 20 86649 22579 29843230
Acute kidney injury 21.71 12.79 615 86054 273227 29592582
Genotoxicity 21.66 12.79 7 86662 34 29865775
Rash pruritic 21.66 12.79 20 86649 22552 29843257
Granulocyte count decreased 21.65 12.79 17 86652 662 29865147
Central nervous system fungal infection 21.61 12.79 12 86657 257 29865552
Non-Hodgkin's lymphoma 21.59 12.79 26 86643 1725 29864084
Respiratory arrest 21.54 12.79 32 86637 29226 29836583
Dyspepsia 21.54 12.79 34 86635 30295 29835514
Positron emission tomogram abnormal 21.40 12.79 9 86660 101 29865708
Hepatitis 21.40 12.79 124 86545 22232 29843577
Rectal haemorrhage 21.36 12.79 43 86626 34896 29830913
Arteriosclerosis 21.31 12.79 3 86666 10830 29854979
Angioedema 21.29 12.79 42 86627 34342 29831467
Paraplegia 21.29 12.79 32 86637 2629 29863180
Pseudomonas test positive 21.29 12.79 20 86649 996 29864813
Erectile dysfunction 21.27 12.79 13 86656 18089 29847720
Focal nodular hyperplasia 21.25 12.79 10 86659 149 29865660
Hallucination, visual 21.24 12.79 10 86659 16103 29849706
Lactic acidosis 21.22 12.79 36 86633 31177 29834632
Molluscum contagiosum 21.16 12.79 12 86657 268 29865541
Metastases to retroperitoneum 21.08 12.79 11 86658 207 29865602
Acute erythroid leukaemia 21.07 12.79 10 86659 152 29865657
Facial paresis 21.01 12.79 33 86636 2817 29862992
Splenic marginal zone lymphoma 20.87 12.79 7 86662 39 29865770
Hepatic amoebiasis 20.87 12.79 8 86661 69 29865740
Drug clearance decreased 20.86 12.79 22 86647 1261 29864548
Erythema 20.73 12.79 135 86534 77316 29788493
Extravasation 20.69 12.79 26 86643 1802 29864007
Disorientation 20.67 12.79 37 86632 31381 29834428
B-cell type acute leukaemia 20.65 12.79 12 86657 281 29865528
Escherichia test positive 20.62 12.79 20 86649 1037 29864772
Immunosuppression 20.61 12.79 46 86623 5129 29860680
Labelled drug-drug interaction medication error 20.54 12.79 3 86666 10535 29855274
Dermatitis diaper 20.54 12.79 12 86657 284 29865525
Peritonitis bacterial 20.50 12.79 4 86665 11374 29854435
Personality change due to a general medical condition 20.44 12.79 7 86662 42 29865767
Suspected product quality issue 20.39 12.79 10 86659 164 29865645
Hepatitis D 20.30 12.79 7 86662 43 29865766
Haemorrhage 20.25 12.79 67 86602 46012 29819797
Haematopoietic stem cell mobilisation 20.12 12.79 10 86659 169 29865640
Glioblastoma multiforme 20.05 12.79 18 86651 845 29864964
Cerebral toxoplasmosis 20.05 12.79 23 86646 1449 29864360
Sphingomonas paucimobilis infection 20.03 12.79 7 86662 45 29865764
Parainfluenzae virus infection 19.98 12.79 27 86642 2011 29863798
Anger 19.84 12.79 4 86665 11116 29854693
Retinal haemorrhage 19.84 12.79 43 86626 4700 29861109
Muscle rigidity 19.82 12.79 3 86666 10258 29855551
Periorbital infection 19.76 12.79 9 86660 124 29865685
Eczema 19.72 12.79 7 86662 13362 29852447
Burkitt's lymphoma 19.71 12.79 10 86659 177 29865632
Arthritis 19.66 12.79 25 86644 24376 29841433
Diaphragm muscle weakness 19.66 12.79 8 86661 82 29865727
Anaplastic large-cell lymphoma 19.66 12.79 10 86659 178 29865631
Disturbance in attention 19.63 12.79 21 86648 22108 29843701
Disseminated cryptococcosis 19.51 12.79 19 86650 990 29864819
Renal impairment 19.49 12.79 153 86516 84031 29781778
Dehydration 19.23 12.79 247 86422 123292 29742517
Chronic myeloid leukaemia 19.22 12.79 30 86639 2547 29863262
Blood HIV RNULL increased 19.08 12.79 22 86647 1394 29864415
Stomatitis necrotising 19.00 12.79 8 86661 90 29865719
Peripheral sensorimotor neuropathy 18.94 12.79 21 86648 1274 29864535
Head injury 18.94 12.79 13 86656 17007 29848802
Localised infection 18.93 12.79 8 86661 13729 29852080
Bone sarcoma 18.92 12.79 8 86661 91 29865718
Vocal cord paralysis 18.90 12.79 17 86652 800 29865009
Metastases to spleen 18.90 12.79 12 86657 331 29865478
Abdominal neoplasm 18.80 12.79 10 86659 196 29865613
Gastrointestinal haemorrhage 18.70 12.79 153 86516 83293 29782516
Fungal sepsis 18.68 12.79 16 86653 705 29865104
Transaminases increased 18.62 12.79 124 86545 23333 29842476
Marginal zone lymphoma recurrent 18.59 12.79 6 86663 29 29865780
Granulocytopenia neonatal 18.59 12.79 6 86663 29 29865780
Metastases to muscle 18.48 12.79 10 86659 203 29865606
Superior vena cava syndrome 18.45 12.79 13 86656 428 29865381
Basal cell naevus syndrome 18.43 12.79 6 86663 30 29865779
Bacillus test positive 18.43 12.79 6 86663 30 29865779
Skin exfoliation 18.40 12.79 24 86645 23148 29842661
Platelet count abnormal 18.37 12.79 28 86641 2329 29863480
Hypersomnia 18.35 12.79 5 86664 11311 29854498
Vascular access complication 18.35 12.79 10 86659 206 29865603
Candida endophthalmitis 18.33 12.79 8 86661 99 29865710
Diabetes mellitus inadequate control 18.29 12.79 7 86662 12755 29853054
Phlebitis infective 18.28 12.79 9 86660 149 29865660
Enterovesical fistula 18.25 12.79 15 86654 624 29865185
Candida sepsis 18.15 12.79 19 86650 1080 29864729
Gastric stenosis 18.11 12.79 6 86663 32 29865777
5q minus syndrome 18.01 12.79 9 86660 154 29865655
Infusion site discolouration 17.91 12.79 8 86661 105 29865704
Orthostatic hypotension 17.88 12.79 26 86643 23953 29841856
Protein C decreased 17.87 12.79 5 86664 13 29865796
Skin toxicity 17.84 12.79 33 86636 3216 29862593
Platelet transfusion 17.83 12.79 18 86651 980 29864829
Bronchitis 17.81 12.79 56 86613 39069 29826740
Cutaneous T-cell lymphoma recurrent 17.81 12.79 6 86663 34 29865775
Gastrointestinal inflammation 17.76 12.79 31 86638 2888 29862921
Swollen tongue 17.68 12.79 8 86661 13184 29852625
Acinetobacter infection 17.65 12.79 18 86651 992 29864817
Sopor 17.56 12.79 5 86664 10986 29854823
Cerebral salt-wasting syndrome 17.52 12.79 6 86663 36 29865773
Chromosome analysis abnormal 17.51 12.79 8 86661 111 29865698
Enterococcal infection 17.48 12.79 58 86611 8166 29857643
Adenocarcinoma gastric 17.42 12.79 19 86650 1132 29864677
Accidental exposure to product 17.31 12.79 4 86665 10111 29855698
Pulmonary sarcoidosis 17.25 12.79 14 86655 572 29865237
Vasogenic cerebral oedema 17.25 12.79 13 86656 476 29865333
Pneumaturia 17.25 12.79 6 86663 38 29865771
Sinusitis bacterial 17.25 12.79 11 86658 306 29865503
Exposure during pregnancy 17.23 12.79 3 86666 9258 29856551
B-lymphocyte count decreased 17.22 12.79 13 86656 477 29865332
Renal tubular disorder 17.20 12.79 42 86627 4964 29860845
Hepatitis viral 17.15 12.79 13 86656 480 29865329
Proteinuria 17.09 12.79 13 86656 16132 29849677
Cranial nerve disorder 17.06 12.79 12 86657 394 29865415
Cavernous sinus thrombosis 17.01 12.79 8 86661 119 29865690
Bacterial infection 17.00 12.79 77 86592 12533 29853276
Protein S decreased 16.98 12.79 6 86663 40 29865769
Taeniasis 16.85 12.79 7 86662 76 29865733
Central nervous system neoplasm 16.73 12.79 6 86663 42 29865767
Lymphoplasmacytoid lymphoma/immunocytoma 16.73 12.79 6 86663 42 29865767
Streptococcal infection 16.71 12.79 40 86629 4668 29861141
Therapy responder 16.71 12.79 9 86660 181 29865628
Limb discomfort 16.69 12.79 3 86666 9047 29856762
Ocular hyperaemia 16.67 12.79 3 86666 9040 29856769
Iron deficiency anaemia 16.62 12.79 3 86666 9021 29856788
Plasma cell myeloma refractory 16.61 12.79 6 86663 43 29865766
Precursor T-lymphoblastic lymphoma/leukaemia 16.53 12.79 7 86662 80 29865729
Hallucination, auditory 16.50 12.79 4 86665 9785 29856024
Peripheral T-cell lymphoma unspecified stage III 16.50 12.79 6 86663 44 29865765
Adult T-cell lymphoma/leukaemia 16.41 12.79 10 86659 256 29865553
Hepatitis B DNULL increased 16.39 12.79 13 86656 514 29865295
Diffuse large B-cell lymphoma stage II 16.27 12.79 6 86663 46 29865763
Central nervous system enteroviral infection 16.27 12.79 6 86663 46 29865763
Drug eruption 16.26 12.79 16 86653 17510 29848299
Helicobacter sepsis 16.25 12.79 5 86664 20 29865789
Premature ageing 16.23 12.79 7 86662 84 29865725
Non-alcoholic steatohepatitis 16.05 12.79 15 86654 742 29865067
T-cell lymphoma recurrent 16.05 12.79 6 86663 48 29865761
Ototoxicity 16.03 12.79 20 86649 1376 29864433
Paresis 16 12.79 23 86646 1815 29863994
Injection site swelling 16.00 12.79 3 86666 8777 29857032
Subclavian vein thrombosis 15.95 12.79 16 86653 864 29864945
Heart rate increased 15.87 12.79 58 86611 38663 29827146
Dry mouth 15.86 12.79 26 86643 22824 29842985
Lymphoproliferative disorder 15.84 12.79 26 86643 2304 29863505
Blood lactate dehydrogenase increased 15.81 12.79 108 86561 20493 29845316
Gastrointestinal injury 15.81 12.79 11 86658 355 29865454
Klebsiella sepsis 15.71 12.79 22 86647 1695 29864114
Rectal adenoma 15.69 12.79 5 86664 23 29865786
White blood cell count abnormal 15.66 12.79 28 86641 2658 29863151
Pancreatitis 15.63 12.79 168 86501 36322 29829487
Metapneumovirus infection 15.59 12.79 13 86656 552 29865257
Diabetic ketoacidosis 15.53 12.79 14 86655 15972 29849837
Accidental overdose 15.49 12.79 18 86651 18257 29847552
Prescribed overdose 15.44 12.79 3 86666 8558 29857251
Embolism 15.40 12.79 50 86619 6959 29858850
Angiodysplasia 15.40 12.79 12 86657 462 29865347
Fibrosarcoma 15.36 12.79 5 86664 25 29865784
Refractory cytopenia with multilineage dysplasia 15.35 12.79 8 86661 150 29865659
Humoral immune defect 15.33 12.79 6 86663 55 29865754
Postural tremor 15.31 12.79 10 86659 290 29865519
Irritability 15.29 12.79 27 86642 23023 29842786
Lymphocytic leukaemia 15.26 12.79 8 86661 152 29865657
Injection site reaction 15.26 12.79 6 86663 10754 29855055
Klebsiella bacteraemia 15.22 12.79 17 86652 1040 29864769
Hyperpyrexia 15.20 12.79 27 86642 2550 29863259
Blood cholesterol increased 15.17 12.79 16 86653 16954 29848855
Skin discolouration 15.14 12.79 14 86655 15780 29850029
Optic nerve disorder 15.14 12.79 13 86656 575 29865234
Retroperitoneal lymphadenopathy 15.11 12.79 14 86655 685 29865124
Extrapyramidal disorder 15.10 12.79 6 86663 10687 29855122
Lower respiratory tract infection fungal 15.08 12.79 13 86656 578 29865231
Leukaemia 15.08 12.79 31 86638 3266 29862543
Vocal cord paresis 15.08 12.79 7 86662 101 29865708
Urinary retention 15.06 12.79 47 86622 32870 29832939
Transplant rejection 15.06 12.79 4 86665 9202 29856607
Ganglioneuroma 15.02 12.79 4 86665 8 29865801
Peroneal nerve palsy 14.89 12.79 26 86643 2423 29863386
Pneumonia cytomegaloviral 14.86 12.79 28 86641 2768 29863041
Mantle cell lymphoma stage IV 14.79 12.79 6 86663 61 29865748
Extramedullary haemopoiesis 14.79 12.79 6 86663 61 29865748
Neutrophil percentage decreased 14.78 12.79 11 86658 395 29865414
Congenital hepatobiliary anomaly 14.74 12.79 5 86664 29 29865780
Cytomegalovirus enterocolitis 14.73 12.79 15 86654 825 29864984
Urticaria 14.70 12.79 95 86574 54511 29811298
Neutrophil count abnormal 14.69 12.79 19 86650 1356 29864453
Swelling 14.67 12.79 54 86615 35921 29829888
Retinoblastoma 14.60 12.79 5 86664 30 29865779
Psychomotor hyperactivity 14.59 12.79 3 86666 8221 29857588
Salivary gland atrophy 14.55 12.79 3 86666 0 29865809
Alveolar rhabdomyosarcoma 14.55 12.79 3 86666 0 29865809
Anal candidiasis 14.55 12.79 3 86666 0 29865809
Febrile infection 14.54 12.79 21 86648 1664 29864145
Blood bilirubin increased 14.48 12.79 166 86503 36470 29829339
Paternal exposure timing unspecified 14.46 12.79 5 86664 31 29865778
Lewis-Sumner syndrome 14.46 12.79 5 86664 31 29865778
Muscle twitching 14.41 12.79 3 86666 8152 29857657
Lung adenocarcinoma stage I 14.41 12.79 4 86665 10 29865799
Astrocytoma 14.38 12.79 8 86661 172 29865637
Duodenal obstruction 14.37 12.79 7 86662 113 29865696
Human metapneumovirus test positive 14.37 12.79 6 86663 66 29865743
Body temperature decreased 14.34 12.79 5 86664 9650 29856159
Hypouricaemia 14.31 12.79 9 86660 244 29865565
Meningitis bacterial 14.31 12.79 17 86652 1112 29864697
Hypertension 14.30 12.79 256 86413 121098 29744711
Enteritis 14.24 12.79 47 86622 6598 29859211
Ureteric compression 14.20 12.79 5 86664 33 29865776
Areflexia 14.16 12.79 27 86642 2692 29863117
Dyskinesia 14.10 12.79 26 86643 21808 29844001
Hemiparesis 14.10 12.79 82 86587 14720 29851089
Chronic lymphocytic leukaemia recurrent 14.04 12.79 11 86658 427 29865382
Secondary immunodeficiency 14.02 12.79 10 86659 336 29865473
Hepatitis B surface antigen positive 13.95 12.79 7 86662 121 29865688
Mastitis 13.93 12.79 8 86661 183 29865626
Diverticulitis 13.92 12.79 18 86651 17427 29848382
Skin cancer 13.92 12.79 3 86666 7958 29857851
Respiratory depression 13.88 12.79 8 86661 11495 29854314
Peripheral T-cell lymphoma unspecified refractory 13.88 12.79 4 86665 12 29865797
Intracranial pressure increased 13.87 12.79 31 86638 3459 29862350
Cancer fatigue 13.82 12.79 5 86664 36 29865773
Pulmonary veno-occlusive disease 13.75 12.79 11 86658 440 29865369
Oral candidiasis 13.75 12.79 66 86603 11005 29854804
Guillain-Barre syndrome 13.74 12.79 39 86630 5044 29860765
Meningoradiculitis 13.59 12.79 5 86664 38 29865771
Iris atrophy 13.55 12.79 6 86663 77 29865732
Blood urea increased 13.53 12.79 46 86623 31335 29834474
Mucosal toxicity 13.52 12.79 8 86661 194 29865615
Acute respiratory distress syndrome 13.49 12.79 115 86554 23357 29842452
Acinetobacter sepsis 13.48 12.79 5 86664 39 29865770
Primary effusion lymphoma 13.48 12.79 5 86664 39 29865770
Obesity 13.47 12.79 4 86665 8551 29857258
Mononeuropathy multiplex 13.45 12.79 7 86662 131 29865678
Chronic lymphocytic leukaemia transformation 13.34 12.79 8 86661 199 29865610
Skin laceration 13.33 12.79 8 86661 11243 29854566
Rash maculo-papular 13.32 12.79 34 86635 25384 29840425
Diabetes mellitus 13.32 12.79 69 86600 41796 29824013
Gastrointestinal mucosal disorder 13.30 12.79 10 86659 365 29865444
Blood urine present 13.27 12.79 6 86663 9894 29855915
Neurological decompensation 13.23 12.79 24 86645 2304 29863505
Ventricular tachycardia 13.23 12.79 31 86638 23831 29841978
Condition aggravated 13.20 12.79 301 86368 137565 29728244
Geotrichum infection 13.15 12.79 11 86658 469 29865340
Type 2 diabetes mellitus 13.15 12.79 12 86657 13610 29852199
Deafness 13.15 12.79 62 86607 10263 29855546
Hepatosplenic T-cell lymphoma 13.13 12.79 11 86658 470 29865339
Coronary artery occlusion 13.13 12.79 8 86661 11149 29854660
Wound 13.11 12.79 10 86659 12392 29853417
Varicella 13.11 12.79 19 86650 1511 29864298
Frequent bowel movements 13.10 12.79 4 86665 8401 29857408
Liver tenderness 13.08 12.79 7 86662 139 29865670
Quadriplegia 13.06 12.79 19 86650 1516 29864293
Bladder cancer 13.03 12.79 5 86664 9097 29856712
Cryptococcal fungaemia 13.02 12.79 6 86663 85 29865724
Hypertensive crisis 12.99 12.79 4 86665 8353 29857456
Meningitis cryptococcal 12.98 12.79 22 86647 2002 29863807
Splenic candidiasis 12.96 12.79 6 86663 86 29865723
Non-Hodgkin's lymphoma unspecified histology aggressive 12.96 12.79 5 86664 44 29865765
Sinus bradycardia 12.92 12.79 9 86660 11686 29854123
Pyomyositis 12.90 12.79 7 86662 143 29865666
B precursor type acute leukaemia 12.90 12.79 6 86663 87 29865722
No adverse event 12.87 12.79 19 86650 17400 29848409
Acute myocardial infarction 12.82 12.79 95 86574 52844 29812965
Kidney transplant rejection 12.79 12.79 3 86666 7506 29858303
Renal disorder 12.79 12.79 31 86638 23553 29842256

Pharmacologic Action:

SourceCodeDescription
ATC L01CA02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Vinca alkaloids and analogues
FDA CS M0022674 Vinca Alkaloids
FDA EPC N0000175612 Vinca Alkaloid
MeSH PA D050256 Antimitotic Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000972 Antineoplastic Agents, Phytogenic
MeSH PA D050257 Tubulin Modulators
CHEBI has role CHEBI:23888 drugs
CHEBI has role CHEBI:35610 cytostatic
CHEBI has role CHEBI:60832 tubulin modulators
CHEBI has role CHEBI:61951 microtubule destabilising role
CHEBI has role CHEBI:76924 plant metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Acute lymphoid leukemia indication 91857003 DOID:9952
Diffuse non-Hodgkin's lymphoma, large cell indication 109969005
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Rhabdomyosarcoma indication 302847003 DOID:3247
Nephroblastoma indication 302849000 DOID:2154
Follicular non-Hodgkin's lymphoma indication 308121000
Neuroblastoma indication 432328008 DOID:769
Astrocytoma, anaplastic off-label use 55353007 DOID:3078
Ewing's sarcoma off-label use 76909002 DOID:3369
Chronic lymphoid leukemia, disease off-label use 92814006
Multiple myeloma off-label use 109989006 DOID:9538
Mycosis fungoides off-label use 118618005
Small cell carcinoma of lung off-label use 254632001 DOID:5409
Glioblastoma multiforme of brain off-label use 276828006 DOID:3073
Primary cutaneous T-cell lymphoma off-label use 400122007
Ovarian Germ Cell Tumor Carcinoma off-label use
Mycosis contraindication 3218000 DOID:1564
Hyperbilirubinemia contraindication 14783006 DOID:2741
Obstruction of bile duct contraindication 30144000
Viral disease contraindication 34014006 DOID:934
Hyperuricemia contraindication 35885006 DOID:1920
Charcot-Marie-Tooth disease contraindication 50548001
Hepatic failure contraindication 59927004
Leukopenia contraindication 84828003 DOID:615
Bacterial infectious disease contraindication 87628006
Peripheral motor neuropathy contraindication 95663000 DOID:683
Neuromyopathy contraindication 255522009 DOID:440
Uric acid renal calculus contraindication 274401005
Pregnancy, function contraindication 289908002
Peripheral nerve disease contraindication 302226006
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Protozoal Infection contraindication
Polyneuropathies contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.02 acidic
pKa2 13.81 acidic
pKa3 7.2 Basic
pKa4 6.58 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tubulin beta Tumour-associated antigen INHIBITOR SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Multidrug resistance-associated protein 7 Transporter WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter WOMBAT-PK
Canalicular multispecific organic anion transporter 1 Transporter WOMBAT-PK
Multidrug resistance protein 1 Transporter WOMBAT-PK
Tubulin Structural IC50 5.74 CHEMBL

External reference:

IDSource
4019971 VUID
N0000148056 NUI
D02197 KEGG_DRUG
2068-78-2 SECONDARY_CAS_RN
4017542 VANDF
4019971 VANDF
C0591904 UMLSCUI
CHEBI:28445 CHEBI
R1Q PDB_CHEM_ID
5978 PUBCHEM_CID
CHEMBL501867 ChEMBL_ID
CHEMBL90555 ChEMBL_ID
D014750 MESH_DESCRIPTOR_UI
1440 INN_ID
5J49Q6B70F UNII
6785 IUPHAR_LIGAND_ID
DB00541 DRUGBANK_ID
11202 RXNORM
5133 MMSL
5675 MMSL
7308 MMSL
879 MMSL
d00401 MMSL
002656 NDDF
004894 NDDF
23079006 SNOMEDCT_US
387126006 SNOMEDCT_US
387427007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Vincasar PFS HUMAN PRESCRIPTION DRUG LABEL 1 0703-4402 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 20 sections
Vincasar PFS HUMAN PRESCRIPTION DRUG LABEL 1 0703-4412 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 20 sections
VinCRIStine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 61703-309 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 22 sections
VinCRIStine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 61703-309 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 22 sections