vincristine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
vinca alkaloids 2825 57-22-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vincristine
  • (+)-Vincristine
  • leucristine
  • vincristin
  • vinkristin
  • 22-oxo-vincaleukoblastine
  • vincristine sulfate
  • oncovin
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
  • Molecular weight: 824.97
  • Formula: C46H56N4O10
  • CLOGP: 3.07
  • LIPINSKI: 2
  • HAC: 14
  • HDO: 3
  • TPSA: 171.17
  • ALOGS: -4.44
  • ROTB: 10
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 15 % Benet LZ, Broccatelli F, Oprea TI
Vd (Volume of distribution) 2.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.40 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 23 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.360 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 49.091 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.507 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 4.217 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 24.070 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 36.950 % High 1
herg hERG pIC50 4.480 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 1.968 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 31.405 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 34.420 % High 1
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK3,MAP3K7,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CA,PIK3CB,PIM2,PRKDC,TEK,TGFBR1,ZAP70 28
kinase-selectivity-class MAP2K6 1
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.549 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 9.036 High 1
mh-clint Mouse hepatocyte intrinsic clearance 13.900 High 1
mppb Mouse plasma protein binding (% unbound) 25.750 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 11.561 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 0.89
pppb Pig plasma protein binding (% unbound) 38.740 % High 1
rat-kpuu-brain Rat brain Kpuu 0.009 % High 1
rh-clint Rat hepatocyte intrinsic clearance 3.681 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 54.250 % High 1
rppb Rat plasma protein binding (% unbound) 22.500 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 741.310 uM High 1

Approvals:

DateAgencyCompanyOrphan
July 10, 1963 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 6893.35 16.31 3272 86109 155077 90383989
Disease progression 2564.64 16.31 1708 87673 154907 90384159
Neutropenia 2249.04 16.31 1821 87560 223083 90315983
Diffuse large B-cell lymphoma recurrent 1176.50 16.31 330 89051 3196 90535870
Pancytopenia 1151.19 16.31 951 88430 119312 90419754
Febrile bone marrow aplasia 965.80 16.31 363 89018 9375 90529691
Myelosuppression 963.69 16.31 621 88760 52970 90486096
Haematotoxicity 948.55 16.31 384 88997 12151 90526915
Mucosal inflammation 934.58 16.31 626 88755 56999 90482067
Thrombocytopenia 763.12 16.31 983 88398 207742 90331324
Second primary malignancy 737.64 16.31 304 89077 10074 90528992
Off label use 711.26 16.31 2536 86845 1099716 89439350
Bone marrow failure 702.03 16.31 422 88959 31799 90507267
Acute myeloid leukaemia 666.56 16.31 350 89031 20290 90518776
Tumour lysis syndrome 644.26 16.31 282 89099 10870 90528196
Myelodysplastic syndrome 631.37 16.31 339 89042 20564 90518502
Hepatitis B reactivation 622.25 16.31 208 89173 3766 90535300
Septic shock 608.73 16.31 568 88813 83592 90455474
Venoocclusive liver disease 596.40 16.31 224 89157 5769 90533297
Sepsis 595.38 16.31 807 88574 179007 90360059
Posterior reversible encephalopathy syndrome 577.63 16.31 327 89054 22012 90517054
Disease recurrence 539.20 16.31 379 89002 37274 90501792
Product use in unapproved indication 495.90 16.31 1051 88330 335185 90203881
Neoplasm progression 471.94 16.31 374 89007 44112 90494954
Neuropathy peripheral 470.38 16.31 626 88755 136344 90402722
Pain 466.10 16.31 201 89180 996140 89542926
Therapy partial responder 460.26 16.31 281 89100 21762 90517304
Cytopenia 444.58 16.31 253 89128 17196 90521870
Joint swelling 426.71 16.31 16 89365 503284 90035782
Multiple organ dysfunction syndrome 412.90 16.31 418 88963 67918 90471148
Leukopenia 409.96 16.31 501 88880 100209 90438857
Neurotoxicity 408.56 16.31 258 89123 21209 90517857
Cardiotoxicity 407.63 16.31 207 89174 11182 90527884
Cytokine release syndrome 406.13 16.31 284 89097 27689 90511377
Hypofibrinogenaemia 379.77 16.31 111 89270 1259 90537807
Acute lymphocytic leukaemia recurrent 365.62 16.31 127 89254 2594 90536472
Abdominal discomfort 362.03 16.31 29 89352 477299 90061767
Blood lactate dehydrogenase increased 357.28 16.31 255 89126 25677 90513389
Malignant neoplasm progression 352.36 16.31 479 88902 106391 90432675
Anaemia 341.13 16.31 937 88444 351865 90187201
Rheumatoid arthritis 336.35 16.31 4 89377 362610 90176456
Diffuse large B-cell lymphoma refractory 333.42 16.31 107 89274 1693 90537373
Neutropenic sepsis 332.82 16.31 213 89168 17917 90521149
Arthropathy 331.32 16.31 6 89375 366236 90172830
Systemic lupus erythematosus 331.27 16.31 5 89376 361891 90177175
Neutropenic colitis 327.44 16.31 131 89250 4012 90535054
Ovarian failure 322.19 16.31 102 89279 1541 90537525
Arthralgia 320.00 16.31 186 89195 778336 89760730
Nasopharyngitis 319.35 16.31 21 89360 407083 90131983
Pruritus 316.99 16.31 73 89308 541452 89997614
Synovitis 308.74 16.31 3 89378 329749 90209317
Swelling 297.69 16.31 33 89348 419025 90120041
Pyrexia 280.63 16.31 1340 88041 659145 89879921
Peripheral swelling 266.23 16.31 44 89337 413062 90126004
Wound 266.01 16.31 7 89374 302973 90236093
Haemophagocytic lymphohistiocytosis 265.03 16.31 174 89207 15285 90523781
Weight increased 263.87 16.31 47 89334 417880 90121186
Neutrophil count decreased 260.95 16.31 337 89044 71195 90467871
Staphylococcal bacteraemia 256.39 16.31 132 89249 7337 90531729
Rash 252.96 16.31 248 89133 795852 89743214
Respiratory failure 251.74 16.31 433 88948 117985 90421081
Platelet count decreased 240.56 16.31 461 88920 136508 90402558
Musculoskeletal stiffness 239.42 16.31 13 89368 296519 90242547
Fatigue 235.87 16.31 492 88889 1153531 89385535
Contraindicated product administered 235.61 16.31 22 89359 320117 90218949
Post transplant lymphoproliferative disorder 233.32 16.31 121 89260 6828 90532238
Drug resistance 232.55 16.31 212 89169 30237 90508829
Hypertriglyceridaemia 229.95 16.31 125 89256 7764 90531302
Product dose omission issue 228.78 16.31 15 89366 291672 90247394
Fall 224.85 16.31 97 89284 481713 90057353
Drug hypersensitivity 220.08 16.31 91 89290 463518 90075548
Epstein-Barr virus infection 216.24 16.31 132 89249 10212 90528854
Malaise 214.71 16.31 159 89222 585827 89953239
Bacteraemia 214.25 16.31 177 89204 22123 90516943
Lymphoma 213.77 16.31 145 89236 13446 90525620
Progressive multifocal leukoencephalopathy 213.45 16.31 153 89228 15502 90523564
Polyneuropathy 212.36 16.31 166 89215 19175 90519891
Insomnia 211.53 16.31 37 89344 333437 90205629
Headache 208.88 16.31 331 89050 862415 89676651
B-cell lymphoma recurrent 206.92 16.31 56 89325 468 90538598
Discomfort 206.88 16.31 17 89364 274318 90264748
Cardiomyopathy 201.72 16.31 164 89217 20042 90519024
Psoriatic arthropathy 201.43 16.31 5 89376 228330 90310736
Diffuse large B-cell lymphoma 200.65 16.31 118 89263 8527 90530539
Therapeutic product effect decreased 199.19 16.31 21 89360 277550 90261516
Sinusitis 197.10 16.31 48 89333 343040 90196026
Hepatitis B 197.10 16.31 94 89287 4425 90534641
Systemic candida 194.73 16.31 96 89285 4863 90534203
Asthma 194.26 16.31 11 89370 242149 90296917
Neoplasm recurrence 193.36 16.31 84 89297 3175 90535891
Aplasia 192.52 16.31 89 89292 3902 90535164
Duodenal ulcer perforation 190.93 16.31 6 89375 221282 90317784
Escherichia bacteraemia 190.08 16.31 99 89282 5636 90533430
Hepatic enzyme increased 189.47 16.31 60 89321 360676 90178390
Hypogammaglobulinaemia 187.51 16.31 122 89259 10552 90528514
Dizziness 186.44 16.31 184 89197 589100 89949966
Pneumocystis jirovecii pneumonia 185.94 16.31 161 89220 21455 90517611
Irritable bowel syndrome 185.08 16.31 4 89377 207444 90331622
Impaired healing 183.76 16.31 12 89369 234187 90304879
Urticaria 183.09 16.31 42 89339 312692 90226374
Hyperbilirubinaemia 182.70 16.31 133 89248 13803 90525263
Helicobacter infection 179.84 16.31 11 89370 226839 90312227
Hypersensitivity 178.92 16.31 114 89267 454563 90084503
Pericarditis 177.94 16.31 27 89354 270124 90268942
Contusion 172.77 16.31 22 89359 251194 90287872
Drug intolerance 172.34 16.31 115 89266 447476 90091590
Blister 169.06 16.31 25 89356 254973 90284093
Injury 167.96 16.31 6 89375 197343 90341723
Pneumatosis intestinalis 166.90 16.31 77 89304 3360 90535706
Mobility decreased 165.27 16.31 25 89356 250709 90288357
Clostridium difficile colitis 162.37 16.31 164 89217 26542 90512524
Anxiety 156.56 16.31 55 89326 309717 90229349
Enterococcal infection 155.72 16.31 106 89275 9885 90529181
Blood cholesterol increased 153.77 16.31 14 89367 207998 90331068
Dyspnoea 149.11 16.31 414 88967 880541 89658525
Lymphadenopathy 148.97 16.31 204 89177 45571 90493495
Ileus paralytic 146.61 16.31 80 89301 5005 90534061
Wheezing 145.39 16.31 29 89352 238051 90301015
Injection site pain 145.35 16.31 6 89375 173693 90365373
Bone pain 141.40 16.31 234 89147 61749 90477317
Aspergillus infection 141.21 16.31 103 89278 10720 90528346
Maternal exposure before pregnancy 140.19 16.31 104 89277 11109 90527957
Sleep disorder 139.45 16.31 16 89365 198014 90341052
Leukoencephalopathy 135.91 16.31 75 89306 4798 90534268
Lower respiratory tract infection 134.60 16.31 40 89341 250619 90288447
Alopecia 133.22 16.31 176 89205 494895 90044171
Osteoarthritis 132.50 16.31 18 89363 195712 90343354
White blood cell count decreased 132.48 16.31 414 88967 166695 90372371
Peripheral sensory neuropathy 132.09 16.31 93 89288 9157 90529909
Psoriasis 131.19 16.31 3 89378 147751 90391315
Agranulocytosis 124.62 16.31 163 89218 34839 90504227
Dry mouth 124.42 16.31 17 89364 184042 90355024
Rhinovirus infection 124.39 16.31 76 89305 5887 90533179
Klebsiella infection 123.15 16.31 93 89288 10204 90528862
Enterococcal bacteraemia 122.70 16.31 53 89328 1975 90537091
Lymphopenia 122.03 16.31 131 89250 22750 90516316
Infusion related reaction 121.75 16.31 139 89242 416641 90122425
Feeling abnormal 121.62 16.31 12 89369 167223 90371843
Myelopathy 121.49 16.31 62 89319 3382 90535684
Mucormycosis 121.05 16.31 64 89317 3757 90535309
Blood pressure increased 120.45 16.31 24 89357 197193 90341873
Secondary immunodeficiency 120.30 16.31 53 89328 2073 90536993
Bronchopulmonary aspergillosis 119.04 16.31 95 89286 11303 90527763
Ascites 116.73 16.31 186 89195 47554 90491512
COVID-19 116.49 16.31 399 88982 168444 90370622
Blood culture positive 114.48 16.31 68 89313 5004 90534062
Hepatocellular injury 114.38 16.31 142 89239 28816 90510250
Arthritis 114.17 16.31 15 89366 167300 90371766
Muscle spasms 113.76 16.31 53 89328 251830 90287236
Mantle cell lymphoma recurrent 112.84 16.31 33 89348 375 90538691
Disseminated intravascular coagulation 112.56 16.31 122 89259 21416 90517650
Inappropriate schedule of product administration 111.04 16.31 10 89371 149923 90389143
Smooth muscle cell neoplasm 110.53 16.31 44 89337 1329 90537737
COVID-19 pneumonia 109.35 16.31 111 89270 18066 90521000
Migraine 108.55 16.31 27 89354 190365 90348701
Abdominal pain upper 108.39 16.31 101 89280 332573 90206493
Lennox-Gastaut syndrome 108.38 16.31 30 89351 275 90538791
Cytomegalovirus infection 104.35 16.31 130 89251 26472 90512594
Venoocclusive disease 103.82 16.31 50 89331 2405 90536661
Pain in extremity 102.98 16.31 179 89202 450350 90088716
Acute lymphocytic leukaemia 102.58 16.31 52 89329 2796 90536270
Central nervous system lymphoma 102.58 16.31 47 89334 2018 90537048
Venous thrombosis 101.47 16.31 65 89316 5472 90533594
Gene mutation 101.18 16.31 47 89334 2083 90536983
Confusional state 101.09 16.31 140 89241 386065 90153001
Cardiac failure 99.75 16.31 285 89096 109211 90429855
C-reactive protein abnormal 98.54 16.31 7 89374 127422 90411644
Hypoaesthesia 95.90 16.31 101 89280 314109 90224957
Bacterial infection 94.26 16.31 116 89265 23328 90515738
Hepatitis E 93.63 16.31 43 89338 1856 90537210
Depression 93.58 16.31 95 89286 300506 90238560
Lymphoma transformation 93.01 16.31 25 89356 203 90538863
Road traffic accident 92.51 16.31 3 89378 107623 90431443
Ototoxicity 92.25 16.31 43 89338 1921 90537145
Ejection fraction decreased 91.51 16.31 121 89260 26132 90512934
Loss of personal independence in daily activities 90.96 16.31 13 89368 136092 90402974
Human herpesvirus 6 infection 90.74 16.31 51 89330 3381 90535685
Hepatic failure 90.62 16.31 150 89231 39578 90499488
Temporal lobe epilepsy 90.07 16.31 28 89353 397 90538669
Staphylococcal sepsis 89.13 16.31 74 89307 9309 90529757
Peripheral motor neuropathy 88.98 16.31 42 89339 1931 90537135
Hypoalbuminaemia 88.28 16.31 93 89288 15804 90523262
Human bocavirus infection 87.18 16.31 28 89353 444 90538622
Superior sagittal sinus thrombosis 87.05 16.31 32 89349 774 90538292
Ileus 86.95 16.31 94 89287 16452 90522614
Overdose 86.78 16.31 24 89357 157685 90381381
Pneumocystis jirovecii infection 86.66 16.31 41 89340 1895 90537171
Sciatica 86.52 16.31 3 89378 101379 90437687
Type 2 diabetes mellitus 85.41 16.31 47 89334 203197 90335869
Cystitis haemorrhagic 84.75 16.31 58 89323 5455 90533611
Myeloid leukaemia 84.57 16.31 28 89353 491 90538575
Fungaemia 83.77 16.31 48 89333 3302 90535764
Bronchitis 82.80 16.31 24 89357 152903 90386163
Device related infection 82.50 16.31 114 89267 25672 90513394
Hepatotoxicity 82.49 16.31 156 89225 45686 90493380
Musculoskeletal pain 82.12 16.31 33 89348 171218 90367848
Herpes simplex 81.88 16.31 73 89308 10108 90528958
Dyspepsia 81.58 16.31 47 89334 198113 90340953
Enterobacter infection 81.08 16.31 43 89338 2540 90536526
Glioma 80.80 16.31 26 89355 415 90538651
Congestive cardiomyopathy 80.46 16.31 63 89318 7291 90531775
Immune effector cell-associated neurotoxicity syndrome 80.07 16.31 57 89324 5711 90533355
Vasogenic cerebral oedema 78.99 16.31 34 89347 1256 90537810
Acute hepatic failure 78.66 16.31 104 89277 22457 90516609
Chest pain 78.59 16.31 121 89260 319524 90219542
Left ventricular dysfunction 78.25 16.31 84 89297 14585 90524481
Quadriplegia 78.22 16.31 40 89341 2191 90536875
Leukaemia recurrent 77.96 16.31 35 89346 1432 90537634
Injection site reaction 77.63 16.31 3 89378 92077 90446989
Encephalopathy 76.19 16.31 152 89229 46292 90492774
Neck pain 75.89 16.31 11 89370 113952 90425114
Pleural effusion 75.76 16.31 263 89118 111728 90427338
Hyperglycaemia 75.58 16.31 160 89221 50810 90488256
Memory impairment 75.37 16.31 51 89330 197193 90341873
Hospitalisation 75.31 16.31 17 89364 128083 90410983
Gastrooesophageal reflux disease 75.07 16.31 35 89346 166302 90372764
Adverse drug reaction 73.80 16.31 13 89368 116688 90422378
Haemorrhage intracranial 72.53 16.31 82 89299 15080 90523986
Cytomegalovirus chorioretinitis 72.36 16.31 39 89342 2380 90536686
Glioblastoma multiforme 71.84 16.31 29 89352 909 90538157
Injection site erythema 71.78 16.31 7 89374 98495 90440571
Hypercholesterolaemia 71.38 16.31 8 89373 100884 90438182
JC virus infection 70.79 16.31 40 89341 2679 90536387
Splenomegaly 70.69 16.31 75 89306 12849 90526217
Respiratory distress 70.65 16.31 133 89248 38813 90500253
Pseudomonas infection 70.43 16.31 80 89301 14785 90524281
Candida infection 70.29 16.31 123 89258 33934 90505132
Cervix disorder 69.74 16.31 26 89355 655 90538411
Intentional product misuse 69.05 16.31 5 89376 89599 90449467
Gait inability 68.95 16.31 29 89352 146427 90392639
Gastrosplenic fistula 68.88 16.31 16 89365 65 90539001
Hepatomegaly 68.79 16.31 75 89306 13251 90525815
Cholestasis 68.40 16.31 126 89255 36173 90502893
Cerebral venous thrombosis 68.15 16.31 37 89344 2291 90536775
Pneumonia fungal 67.93 16.31 56 89325 6975 90532091
Gastroenteritis norovirus 67.45 16.31 37 89344 2339 90536727
Aplastic anaemia 67.31 16.31 74 89307 13195 90525871
Pleuroparenchymal fibroelastosis 67.07 16.31 19 89362 191 90538875
Vocal cord paralysis 66.67 16.31 37 89344 2393 90536673
Pseudomonas test positive 65.64 16.31 27 89354 889 90538177
Colitis 65.58 16.31 184 89197 69758 90469308
Epstein-Barr virus associated lymphoma 65.15 16.31 25 89356 683 90538383
Oedema 64.96 16.31 61 89320 200234 90338832
Geotrichum infection 64.85 16.31 24 89357 592 90538474
Cerebral venous sinus thrombosis 64.70 16.31 36 89345 2340 90536726
Joint stiffness 64.26 16.31 3 89378 78039 90461027
Enterovirus test positive 63.71 16.31 18 89363 179 90538887
Clostridium difficile infection 63.55 16.31 122 89259 36123 90502943
Pulmonary haemorrhage 63.54 16.31 57 89324 7956 90531110
Epstein-Barr virus associated lymphoproliferative disorder 63.46 16.31 37 89344 2630 90536436
Adverse event 62.51 16.31 19 89362 117399 90421667
Metastases to meninges 61.49 16.31 41 89340 3694 90535372
Hyperpyrexia 61.41 16.31 45 89336 4716 90534350
Cardiomyopathy acute 60.63 16.31 19 89362 277 90538789
Inappropriate antidiuretic hormone secretion 60.56 16.31 85 89296 19420 90519646
Perineal necrosis 59.96 16.31 16 89365 126 90538940
Strongyloidiasis 59.90 16.31 30 89351 1572 90537494
Palpitations 59.82 16.31 30 89351 136698 90402368
Leukoerythroblastosis 59.77 16.31 19 89362 291 90538775
Perineal infection 59.39 16.31 17 89364 178 90538888
Premature menopause 59.04 16.31 28 89353 1301 90537765
Malignant transformation 58.07 16.31 22 89359 580 90538486
Therapy non-responder 57.39 16.31 277 89104 136427 90402639
Refractory anaemia with an excess of blasts 56.92 16.31 20 89361 423 90538643
Product quality issue 56.86 16.31 6 89375 79319 90459747
Neutropenic infection 56.46 16.31 30 89351 1779 90537287
Intestinal perforation 56.31 16.31 69 89312 13812 90525254
Diarrhoea 55.50 16.31 626 88755 938564 89600502
Gait disturbance 55.44 16.31 108 89273 260388 90278678
Humoral immune defect 55.01 16.31 19 89362 381 90538685
Obesity 54.51 16.31 18 89363 105489 90433577
Autoimmune disorder 54.51 16.31 6 89375 76738 90462328
Infection reactivation 54.49 16.31 30 89351 1910 90537156
Osteonecrosis 54.45 16.31 95 89286 26146 90512920
B precursor type acute leukaemia 54.30 16.31 17 89364 247 90538819
Chronic myelomonocytic leukaemia 54.28 16.31 19 89362 397 90538669
Hepatic cytolysis 54.13 16.31 104 89277 30812 90508254
Tracheo-oesophageal fistula 54.07 16.31 22 89359 704 90538362
Pseudomonal sepsis 54.00 16.31 40 89341 4262 90534804
Klebsiella bacteraemia 53.97 16.31 33 89348 2559 90536507
Cutaneous calcification 53.69 16.31 16 89365 195 90538871
Pyomyositis 53.54 16.31 19 89362 414 90538652
Varicella zoster virus infection 53.09 16.31 38 89343 3839 90535227
Night sweats 52.33 16.31 31 89350 128735 90410331
Inflammation 51.60 16.31 60 89321 178532 90360534
Follicular lymphoma 51.52 16.31 18 89363 374 90538692
Antithrombin III decreased 51.46 16.31 16 89365 227 90538839
Cytomegalovirus infection reactivation 51.29 16.31 50 89331 7750 90531316
Jugular vein thrombosis 51.12 16.31 36 89345 3545 90535521
Influenza like illness 50.92 16.31 9 89372 80602 90458464
Feeling hot 50.85 16.31 8 89373 78000 90461066
Acute promyelocytic leukaemia 50.81 16.31 24 89357 1105 90537961
Gastrointestinal disorder 50.75 16.31 111 89270 256576 90282490
Ear infection 50.73 16.31 5 89376 69770 90469296
Staphylococcal infection 49.97 16.31 132 89249 48307 90490759
B-cell aplasia 49.68 16.31 16 89365 256 90538810
Acute respiratory distress syndrome 49.61 16.31 96 89285 28590 90510476
Cystitis bacterial 49.55 16.31 17 89364 334 90538732
Adenovirus infection 49.28 16.31 39 89342 4583 90534483
Bone marrow disorder 49.23 16.31 33 89348 2999 90536067
Hypertension 49.22 16.31 258 89123 457274 90081792
Bacterial sepsis 48.99 16.31 40 89341 4915 90534151
Oedema peripheral 48.98 16.31 114 89267 257801 90281265
Acute hepatitis B 48.71 16.31 17 89364 352 90538714
Cytomegalovirus viraemia 48.71 16.31 48 89333 7538 90531528
Fusarium infection 48.69 16.31 23 89358 1059 90538007
Amnesia 48.69 16.31 23 89358 108482 90430584
Pneumonia cytomegaloviral 48.46 16.31 33 89348 3078 90535988
Premature delivery 47.73 16.31 113 89268 38649 90500417
Lymphoproliferative disorder 47.69 16.31 37 89344 4225 90534841
Histiocytic sarcoma 47.37 16.31 12 89369 75 90538991
Incorrect dose administered 47.35 16.31 10 89371 78920 90460146
Neurological symptom 47.11 16.31 45 89336 6802 90532264
Condition aggravated 47.10 16.31 369 89012 595176 89943890
Injection site swelling 47.10 16.31 3 89378 59836 90479230
Blood fibrinogen decreased 46.98 16.31 23 89358 1147 90537919
Red blood cell sedimentation rate increased 46.50 16.31 12 89369 82583 90456483
Heart rate abnormal 46.41 16.31 42 89339 5929 90533137
Cardiac dysfunction 46.40 16.31 34 89347 3563 90535503
Back pain 46.35 16.31 159 89222 317016 90222050
Escherichia infection 46.01 16.31 67 89314 15828 90523238
Taste disorder 45.84 16.31 4 89377 61542 90477524
T-cell type acute leukaemia 45.42 16.31 13 89368 136 90538930
Coagulopathy 45.34 16.31 82 89299 23207 90515859
Treatment failure 45.34 16.31 151 89230 303777 90235289
Rhinocerebral mucormycosis 45.16 16.31 20 89361 792 90538274
Babesiosis 44.94 16.31 15 89366 270 90538796
Combined immunodeficiency 44.83 16.31 13 89368 143 90538923
Colitis ulcerative 44.66 16.31 4 89377 60262 90478804
Visual impairment 44.47 16.31 39 89342 132326 90406740
Klebsiella test positive 44.31 16.31 24 89357 1479 90537587
Illness 44.11 16.31 13 89368 81956 90457110
Philadelphia chromosome positive 44.01 16.31 17 89364 473 90538593
5q minus syndrome 43.88 16.31 14 89367 217 90538849
Thrombotic microangiopathy 43.61 16.31 65 89316 15678 90523388
Mucosal toxicity 43.56 16.31 16 89365 386 90538680
Nausea 43.44 16.31 803 88578 1109513 89429553
Soft tissue infection 43.40 16.31 30 89351 2867 90536199
Erythropoiesis abnormal 43.33 16.31 15 89366 303 90538763
Dysplasia 43.17 16.31 23 89358 1371 90537695
Seizure 43.16 16.31 278 89103 152351 90386715
Ureaplasma infection 43.08 16.31 20 89361 885 90538181
Paraparesis 43.02 16.31 30 89351 2908 90536158
Streptococcal bacteraemia 42.94 16.31 27 89354 2200 90536866
Acute pulmonary oedema 42.77 16.31 50 89331 9530 90529536
Osteomyelitis bacterial 42.74 16.31 14 89367 237 90538829
Pneumonia 42.73 16.31 874 88507 637185 89901881
Drug abuse 42.63 16.31 14 89367 82333 90456733
Herpes zoster meningoencephalitis 42.62 16.31 16 89365 411 90538655
Iris atrophy 42.60 16.31 12 89369 118 90538948
Minimal residual disease 42.37 16.31 16 89365 418 90538648
Hepatic cirrhosis 42.35 16.31 6 89375 63247 90475819
Stenotrophomonas bacteraemia 42.33 16.31 12 89369 121 90538945
Fluid retention 42.17 16.31 17 89364 88074 90450992
Enterovirus infection 41.97 16.31 23 89358 1451 90537615
BK virus infection 41.74 16.31 35 89346 4463 90534603
B-cell lymphoma 41.55 16.31 32 89349 3614 90535452
Injection site pruritus 41.49 16.31 3 89378 53831 90485235
Hyperhidrosis 41.33 16.31 44 89337 136261 90402805
Fanconi syndrome 41.13 16.31 25 89356 1918 90537148
Synovial sarcoma 40.87 16.31 10 89371 53 90539013
Ill-defined disorder 40.78 16.31 75 89306 184816 90354250
Vaccination failure 40.37 16.31 21 89360 1192 90537874
Transverse sinus thrombosis 40.22 16.31 17 89364 600 90538466
Peripheral sensorimotor neuropathy 39.95 16.31 25 89356 2020 90537046
Escherichia sepsis 39.59 16.31 38 89343 5778 90533288
Weight decreased 39.30 16.31 217 89164 379693 90159373
Hot flush 39.00 16.31 6 89375 59482 90479584
Vision blurred 38.90 16.31 31 89350 110262 90428804
Therapy responder 38.82 16.31 14 89367 320 90538746
Blood glucose increased 38.60 16.31 23 89358 95223 90443843
Hepatic infarction 38.49 16.31 17 89364 669 90538397
Paraesthesia 38.27 16.31 123 89258 250203 90288863
Hepatitis B core antibody positive 38.15 16.31 14 89367 337 90538729
Pseudomonal bacteraemia 38.01 16.31 24 89357 1970 90537096
Lymphadenitis 37.99 16.31 32 89349 4105 90534961
Hypokalaemia 37.80 16.31 240 89141 130876 90408190
Anisometropia 37.56 16.31 10 89371 78 90538988
Dry skin 37.51 16.31 20 89361 88053 90451013
Suicidal ideation 37.46 16.31 13 89368 73842 90465224
Enterocolitis infectious 37.43 16.31 24 89357 2023 90537043
Leukaemic lymphoma 37.33 16.31 10 89371 80 90538986
Meningitis cryptococcal 37.31 16.31 23 89358 1810 90537256
Pneumonia klebsiella 37.30 16.31 28 89353 3044 90536022
Retinal pigment epitheliopathy 37.13 16.31 13 89368 272 90538794
Human rhinovirus test positive 37.01 16.31 18 89363 885 90538181
B-cell type acute leukaemia 36.87 16.31 16 89365 603 90538463
Endometrial adenocarcinoma 36.86 16.31 21 89360 1429 90537637
Pancreatitis acute 36.73 16.31 91 89290 32024 90507042
Gastrointestinal toxicity 36.70 16.31 46 89335 9421 90529645
Lung infiltration 36.60 16.31 59 89322 15223 90523843
Drug ineffective 36.48 16.31 1690 87691 1382608 89156458
Intentional product use issue 36.44 16.31 102 89279 216790 90322276
Hydrocephalus 36.26 16.31 37 89344 6057 90533009
Leukaemia cutis 36.26 16.31 11 89370 143 90538923
Platelet transfusion 36.16 16.31 19 89362 1101 90537965
Burning sensation 36.14 16.31 9 89372 63443 90475623
Gastrointestinal necrosis 36.09 16.31 28 89353 3197 90535869
Metastasis 36.04 16.31 37 89344 6100 90532966
Myeloproliferative neoplasm 35.84 16.31 16 89365 646 90538420
Eczema 35.43 16.31 5 89376 52865 90486201
Toxic neuropathy 35.39 16.31 15 89366 533 90538533
Antithrombin III 35.38 16.31 11 89370 156 90538910
Nail pigmentation 35.11 16.31 12 89369 233 90538833
Alanine aminotransferase increased 34.98 16.31 218 89163 118120 90420946
Platelet count abnormal 34.69 16.31 31 89350 4304 90534762
Tissue infiltration 34.63 16.31 17 89364 853 90538213
Nephropathy toxic 34.59 16.31 52 89329 12636 90526430
Granulocytopenia 34.56 16.31 37 89344 6404 90532662
Ventricular dysfunction 34.55 16.31 29 89352 3702 90535364
Small intestinal obstruction 34.23 16.31 69 89312 21165 90517901
Osteoporosis 34.20 16.31 27 89354 96504 90442562
Intussusception 34.20 16.31 18 89363 1047 90538019
Necrotising gastritis 34.17 16.31 9 89372 67 90538999
Cryptococcosis 33.93 16.31 20 89361 1451 90537615
Escherichia test positive 33.90 16.31 25 89356 2645 90536421
Unmasking of previously unidentified disease 33.86 16.31 20 89361 1456 90537610
Metastases to peritoneum 33.82 16.31 30 89351 4125 90534941
Acute respiratory failure 33.66 16.31 106 89275 42812 90496254
Lymphocyte count decreased 33.63 16.31 93 89288 34957 90504109
B-cell lymphoma refractory 33.60 16.31 9 89372 72 90538994
Myalgia 33.56 16.31 77 89304 175048 90364018
Mucoepidermoid carcinoma of salivary gland 33.43 16.31 8 89373 38 90539028
Erythema 33.42 16.31 115 89266 229131 90309935
Salivary gland cancer 33.38 16.31 11 89370 190 90538876
Acute biphenotypic leukaemia 33.28 16.31 9 89372 75 90538991
Depressed mood 33.08 16.31 5 89376 50217 90488849
Fluid replacement 33.04 16.31 15 89366 630 90538436
Necrotising colitis 33.00 16.31 19 89362 1319 90537747
Joint dislocation 32.92 16.31 3 89378 44579 90494487
Leukaemia 32.82 16.31 32 89349 4960 90534106
Pulse waveform abnormal 32.76 16.31 9 89372 80 90538986
Pneumonitis 32.74 16.31 107 89274 44063 90495003
Ankle brachial index decreased 32.66 16.31 9 89372 81 90538985
Nasal congestion 32.61 16.31 21 89360 83393 90455673
Enterobacter bacteraemia 32.46 16.31 16 89365 810 90538256
Pulmonary fibrosis 32.26 16.31 35 89346 107468 90431598
Acute myelomonocytic leukaemia 32.21 16.31 11 89370 213 90538853
Tumour haemorrhage 32.12 16.31 22 89359 2072 90536994
Cerebellar stroke 32.10 16.31 13 89368 411 90538655
Therapeutic response delayed 32.02 16.31 16 89365 834 90538232
Encephalitis viral 31.73 16.31 21 89360 1868 90537198
Primary immunodeficiency syndrome 31.72 16.31 8 89373 49 90539017
White blood cell count abnormal 31.57 16.31 38 89343 7466 90531600
Primary mediastinal large B-cell lymphoma recurrent 31.55 16.31 9 89372 93 90538973
Gas gangrene 31.35 16.31 10 89371 155 90538911
Potentiating drug interaction 31.22 16.31 33 89348 5629 90533437
Carotid intima-media thickness increased 31.20 16.31 9 89372 97 90538969
Listeria sepsis 31.15 16.31 15 89366 721 90538345
Hallucination 31.13 16.31 13 89368 65946 90473120
Brain oedema 31.07 16.31 59 89322 17326 90521740
Flushing 31.04 16.31 25 89356 88466 90450600
Tumour rupture 30.81 16.31 11 89370 244 90538822
Cytomegalovirus colitis 30.70 16.31 26 89355 3360 90535706
Graft versus host disease 30.66 16.31 39 89342 8105 90530961
Aeromonas infection 30.44 16.31 10 89371 171 90538895
Rash pruritic 30.41 16.31 22 89359 82192 90456874
Monoparesis 30.39 16.31 21 89360 2006 90537060
Growth hormone deficiency 30.33 16.31 10 89371 173 90538893
Tachycardia 30.25 16.31 262 89119 157411 90381655
Drug ineffective for unapproved indication 30.12 16.31 138 89243 66506 90472560
Blood pressure systolic increased 30.06 16.31 10 89371 58335 90480731
Loss of consciousness 29.94 16.31 58 89323 140180 90398886
Basal ganglion degeneration 29.91 16.31 12 89369 370 90538696
Subdural hygroma 29.89 16.31 11 89370 267 90538799
Heart rate decreased 29.69 16.31 8 89373 53497 90485569
Subclavian vein thrombosis 29.58 16.31 21 89360 2095 90536971
Tumour necrosis 29.56 16.31 16 89365 985 90538081
Suicide attempt 29.45 16.31 19 89362 75380 90463686
Oesophageal candidiasis 29.42 16.31 35 89346 6794 90532272
Hyperammonaemia 29.25 16.31 34 89347 6441 90532625
Lymphocytosis 29.22 16.31 24 89357 2973 90536093
Rhabdomyosarcoma recurrent 29.12 16.31 7 89374 34 90539032
Streptococcus test positive 29.08 16.31 18 89363 1427 90537639
Epstein-Barr viraemia 28.79 16.31 18 89363 1452 90537614
Trichodysplasia spinulosa 28.75 16.31 14 89367 690 90538376
Polyomavirus-associated nephropathy 28.70 16.31 22 89359 2468 90536598
Premature baby 28.62 16.31 71 89310 25006 90514060
Acute lymphocytic leukaemia refractory 28.46 16.31 8 89373 78 90538988
Encephalitis cytomegalovirus 28.41 16.31 14 89367 708 90538358
Coronavirus infection 28.39 16.31 31 89350 5484 90533582
Blood stem cell transplant failure 28.30 16.31 10 89371 215 90538851
Mediastinum neoplasm 28.28 16.31 8 89373 80 90538986
Treatment noncompliance 28.20 16.31 8 89373 51719 90487347
Live birth 28.19 16.31 22 89359 79085 90459981
Lipase increased 28.13 16.31 44 89337 11067 90527999
Pregnancy 28.07 16.31 13 89368 62034 90477032
Klebsiella sepsis 28 16.31 19 89362 1762 90537304
Hepatosplenic candidiasis 27.99 16.31 11 89370 321 90538745
Metapneumovirus infection 27.81 16.31 17 89364 1318 90537748
Partial seizures 27.70 16.31 35 89346 7225 90531841
Anaesthesia 27.66 16.31 12 89369 452 90538614
Renal-limited thrombotic microangiopathy 27.55 16.31 10 89371 233 90538833
Chronic hepatitis 27.55 16.31 16 89365 1129 90537937
Bacillus infection 27.40 16.31 15 89366 944 90538122
Intra-abdominal haemorrhage 27.40 16.31 22 89359 2640 90536426
Rhinorrhoea 27.34 16.31 28 89353 88288 90450778
Liver function test increased 27.31 16.31 26 89355 84829 90454237
Swollen tongue 27.20 16.31 6 89375 45950 90493116
Enterocolitis 27.20 16.31 42 89339 10448 90528618
Chest discomfort 27.19 16.31 60 89321 138305 90400761
Postictal state 27.14 16.31 17 89364 1376 90537690
Electrolyte imbalance 26.86 16.31 67 89314 23678 90515388
Alveolar soft part sarcoma 26.73 16.31 8 89373 99 90538967
Haemoglobin abnormal 26.73 16.31 34 89347 7066 90532000
Capillary leak syndrome 26.65 16.31 22 89359 2745 90536321
Liver carcinoma ruptured 26.59 16.31 7 89374 52 90539014
Underdose 26.56 16.31 10 89371 54007 90485059
Trichosporon infection 26.52 16.31 11 89370 370 90538696
Cerebrovascular accident 26.45 16.31 51 89330 123482 90415584
Dry eye 26.42 16.31 12 89369 57919 90481147
Parainfluenzae virus infection 26.40 16.31 22 89359 2781 90536285
Haemolytic uraemic syndrome 26.34 16.31 22 89359 2789 90536277
Medulloblastoma recurrent 26.30 16.31 8 89373 105 90538961
Pneumonia influenzal 26.27 16.31 20 89361 2220 90536846
Generalised tonic-clonic seizure 26.27 16.31 85 89296 34818 90504248
Abdominal neoplasm 26.25 16.31 11 89370 380 90538686
Stenotrophomonas infection 26.24 16.31 21 89360 2508 90536558
Pneumonia bacterial 26.14 16.31 46 89335 12744 90526322
Chronic hepatitis B 26.06 16.31 11 89370 387 90538679
Cardiopulmonary failure 25.97 16.31 26 89355 4162 90534904
Paraneoplastic pemphigus 25.96 16.31 8 89373 110 90538956
Liver injury 25.93 16.31 84 89297 170483 90368583
Angioedema 25.82 16.31 16 89365 64860 90474206
Cough 25.79 16.31 236 89145 368726 90170340
SARS-CoV-2 test negative 25.74 16.31 12 89369 536 90538530
Clostridium test positive 25.47 16.31 29 89352 5372 90533694
Myocardial infarction 25.17 16.31 41 89340 105931 90433135
Therapy interrupted 25.10 16.31 9 89372 50099 90488967
Amenorrhoea 25.05 16.31 43 89338 11679 90527387
Haemodynamic instability 25.01 16.31 43 89338 11696 90527370
Acidosis 24.99 16.31 45 89336 12691 90526375
Central nervous system enteroviral infection 24.98 16.31 6 89375 29 90539037
Meningitis 24.91 16.31 36 89345 8445 90530621
Chemotherapeutic drug level increased 24.91 16.31 9 89372 207 90538859
Retroperitoneal lymphadenopathy 24.84 16.31 13 89368 747 90538319
Epstein Barr virus positive mucocutaneous ulcer 24.78 16.31 12 89369 584 90538482
Gastric stenosis 24.74 16.31 7 89374 70 90538996
Asthenia 24.70 16.31 374 89007 533377 90005689
Recurrent cancer 24.62 16.31 20 89361 2439 90536627
Limb discomfort 24.59 16.31 4 89377 38056 90501010
Respiratory syncytial virus infection 24.47 16.31 40 89341 10440 90528626
Atypical haemolytic uraemic syndrome 24.25 16.31 14 89367 977 90538089
Optic glioma 24.13 16.31 5 89376 10 90539056
Metastatic lymphoma 24.13 16.31 9 89372 227 90538839
Hepatic function abnormal 24.08 16.31 100 89281 46188 90492878
Radiation myelopathy 23.90 16.31 6 89375 36 90539030
Overgrowth fungal 23.81 16.31 8 89373 147 90538919
Alpha haemolytic streptococcal infection 23.58 16.31 17 89364 1737 90537329
Gastrointestinal inflammation 23.54 16.31 31 89350 6665 90532401
Acquired gene mutation 23.40 16.31 15 89366 1264 90537802
Pharyngeal inflammation 23.37 16.31 14 89367 1046 90538020
Ear pain 23.29 16.31 14 89367 57688 90481378
Eye irritation 23.28 16.31 3 89378 33975 90505091
Intracardiac thrombus 23.12 16.31 19 89362 2355 90536711
Procalcitonin increased 22.97 16.31 16 89365 1548 90537518
Portal vein embolism 22.94 16.31 7 89374 93 90538973
Cranial nerve disorder 22.84 16.31 12 89369 695 90538371
Uterine enlargement 22.68 16.31 15 89366 1333 90537733
Vulvovaginitis 22.67 16.31 10 89371 392 90538674
Balance disorder 22.65 16.31 38 89343 97042 90442024
Angiocentric lymphoma 22.62 16.31 12 89369 709 90538357
Blast cells present 22.61 16.31 11 89370 541 90538525
Metastases to central nervous system 22.53 16.31 52 89329 17490 90521576
High-grade B-cell lymphoma 22.51 16.31 6 89375 47 90539019
Splenic necrosis 22.51 16.31 6 89375 47 90539019
Enterococcal sepsis 22.50 16.31 16 89365 1600 90537466
Cytogenetic abnormality 22.50 16.31 11 89370 547 90538519
Chromosomal deletion 22.47 16.31 7 89374 100 90538966
Nephroblastoma 22.45 16.31 5 89376 16 90539050
Shock haemorrhagic 22.43 16.31 42 89339 12203 90526863
Peritonitis viral 22.40 16.31 6 89375 48 90539018
Lymphatic duct injury 22.40 16.31 6 89375 48 90539018
Walking aid user 22.34 16.31 4 89377 35502 90503564
Cryptococcal fungaemia 22.28 16.31 7 89374 103 90538963
Device related bacteraemia 22.28 16.31 10 89371 409 90538657
Mucosal infection 22.26 16.31 8 89373 181 90538885
Enteritis 22.24 16.31 38 89343 10283 90528783
Mycobacterial infection 22.18 16.31 18 89363 2192 90536874
Otitis media acute 22.13 16.31 14 89367 1153 90537913
Joint injury 22.10 16.31 3 89378 32661 90506405
Hereditary motor and sensory neuropathy 22.09 16.31 7 89374 106 90538960
Urinary tract infection bacterial 21.95 16.31 29 89352 6256 90532810
Blood bilirubin increased 21.90 16.31 93 89288 43377 90495689
Autonomic neuropathy 21.90 16.31 15 89366 1412 90537654
Somnolence 21.83 16.31 119 89262 208965 90330101
Deep vein thrombosis 21.81 16.31 160 89221 91460 90447606
Periorbital cellulitis 21.78 16.31 12 89369 765 90538301
Pathogen resistance 21.76 16.31 33 89348 8082 90530984
Pericardial effusion malignant 21.74 16.31 8 89373 194 90538872
Myocardial stunning 21.66 16.31 9 89372 304 90538762
Malnutrition 21.66 16.31 53 89328 18505 90520561
Staphylococcus test positive 21.64 16.31 24 89357 4321 90534745
Hypertransaminasaemia 21.54 16.31 48 89333 15777 90523289
Brain injury 21.51 16.31 32 89349 7706 90531360
T-cell lymphoma 21.48 16.31 12 89369 786 90538280
Encephalitis 21.41 16.31 39 89342 11095 90527971
Pericardial calcification 21.39 16.31 5 89376 21 90539045
Autoimmune haemolytic anaemia 21.20 16.31 27 89354 5618 90533448
Unevaluable event 21.18 16.31 14 89367 54834 90484232
Fasciitis 21.05 16.31 11 89370 630 90538436
IIIrd nerve paralysis 21.01 16.31 12 89369 820 90538246
Cancer in remission 20.94 16.31 6 89375 63 90539003
Visceral leishmaniasis 20.93 16.31 11 89370 638 90538428
Interstitial lung disease 20.87 16.31 138 89243 76267 90462799
Throat irritation 20.82 16.31 11 89370 48684 90490382
Medication error 20.82 16.31 32 89349 84620 90454446
Anal squamous cell carcinoma 20.74 16.31 11 89370 650 90538416
Swelling face 20.74 16.31 30 89351 81322 90457744
Refractory cytopenia with multilineage dysplasia 20.62 16.31 7 89374 133 90538933
Endocarditis 20.61 16.31 30 89351 7083 90531983
Abdominal abscess 20.60 16.31 26 89355 5361 90533705
Brain herniation 20.57 16.31 23 89358 4177 90534889
Granulocyte count decreased 20.55 16.31 18 89363 2434 90536632
Jejunal stenosis 20.53 16.31 6 89375 68 90538998
Gastric disorder 20.50 16.31 4 89377 33380 90505686
Stem cell transplant 20.48 16.31 17 89364 2137 90536929
Odynophagia 20.42 16.31 34 89347 9009 90530057
Subacute combined cord degeneration 20.37 16.31 8 89373 233 90538833
Neurological decompensation 20.37 16.31 21 89360 3480 90535586
Muscular weakness 20.29 16.31 120 89261 206546 90332520
Drug clearance decreased 20.20 16.31 16 89365 1882 90537184
Blood immunoglobulin G decreased 20.18 16.31 21 89360 3517 90535549
Hyperglycaemic hyperosmolar nonketotic syndrome 20.10 16.31 14 89367 1355 90537711
Paranasal sinus mucosal hypertrophy 20.06 16.31 5 89376 29 90539037
Genitourinary symptom 20.01 16.31 7 89374 146 90538920
Osteosarcoma 20.01 16.31 7 89374 146 90538920
Lung disorder 19.98 16.31 78 89303 149805 90389261
Vena cava thrombosis 19.93 16.31 18 89363 2534 90536532
Hypoxia 19.92 16.31 131 89250 72268 90466798
Retinoblastoma 19.85 16.31 6 89375 77 90538989
Urethritis 19.84 16.31 8 89373 250 90538816
Sinusitis fungal 19.72 16.31 16 89365 1948 90537118
Ovarian injury 19.65 16.31 4 89377 7 90539059
Areflexia 19.62 16.31 21 89360 3632 90535434
Central nervous system viral infection 19.58 16.31 7 89374 156 90538910
Renal replacement therapy 19.57 16.31 6 89375 81 90538985
Monoplegia 19.52 16.31 21 89360 3653 90535413
Picornavirus infection 19.50 16.31 6 89375 82 90538984
Pericardial effusion 19.50 16.31 80 89301 36753 90502313
Papillary thyroid cancer 19.48 16.31 18 89363 2609 90536457
Adverse reaction 19.47 16.31 3 89378 29709 90509357
Listeria encephalitis 19.46 16.31 8 89373 263 90538803
Nervous system disorder 19.45 16.31 56 89325 21537 90517529
Necrosis 19.33 16.31 28 89353 6582 90532484
Ecthyma 19.25 16.31 9 89372 405 90538661
Campylobacter infection 19.22 16.31 13 89368 1199 90537867
Hepatitis G 19.18 16.31 6 89375 87 90538979
Encephalitis fungal 19.18 16.31 6 89375 87 90538979
Obliterative bronchiolitis 19.17 16.31 18 89363 2663 90536403
Eustachian tube dysfunction 19.14 16.31 11 89370 761 90538305
Chronic kidney disease 19.13 16.31 13 89368 50178 90488888
Toxic epidermal necrolysis 19.11 16.31 73 89308 32455 90506611
Transaminases increased 19.07 16.31 80 89301 37112 90501954
Heart rate increased 19.02 16.31 53 89328 112849 90426217
Flagellate dermatitis 19.01 16.31 7 89374 170 90538896
Paraesthesia oral 19.01 16.31 4 89377 31655 90507411
Peripheral T-cell lymphoma unspecified 18.91 16.31 8 89373 283 90538783
Renal failure 18.87 16.31 205 89176 130802 90408264
Adenoviral haemorrhagic cystitis 18.86 16.31 7 89374 174 90538892
Metastases to lymph nodes 18.86 16.31 38 89343 11651 90527415
Eye pain 18.85 16.31 10 89371 44158 90494908
Mass 18.73 16.31 45 89336 15532 90523534
Gastrointestinal fungal infection 18.68 16.31 9 89372 433 90538633
Bacillus test positive 18.67 16.31 5 89376 40 90539026
Localised infection 18.65 16.31 5 89376 33557 90505509
Oophoritis 18.64 16.31 7 89374 180 90538886
Bilirubin conjugated increased 18.62 16.31 19 89362 3111 90535955
Head injury 18.60 16.31 4 89377 31184 90507882
Drug withdrawal syndrome 18.60 16.31 3 89378 28720 90510346
Laboratory test abnormal 18.58 16.31 9 89372 41845 90497221
Cerebral artery thrombosis 18.46 16.31 9 89372 445 90538621
Optic atrophy 18.45 16.31 14 89367 1547 90537519
Campylobacter gastroenteritis 18.41 16.31 11 89370 818 90538248
Duodenal stenosis 18.41 16.31 10 89371 620 90538446
Acne 18.41 16.31 3 89378 28504 90510562
Lung adenocarcinoma 18.40 16.31 25 89356 5540 90533526
Genital infection 18.39 16.31 7 89374 187 90538879
Hypophagia 18.20 16.31 77 89304 35860 90503206
Primary hypogonadism 18.08 16.31 7 89374 196 90538870
Encopresis 18.08 16.31 6 89375 106 90538960
Lineage switch leukaemia 18.05 16.31 5 89376 46 90539020
Haematopoietic stem cell mobilisation 18.05 16.31 5 89376 46 90539020
Quadriparesis 18.01 16.31 17 89364 2532 90536534
Vulvovaginal inflammation 17.95 16.31 12 89369 1086 90537980
Tessellated fundus 17.86 16.31 5 89376 48 90539018
Skin ulcer 17.74 16.31 14 89367 50061 90489005
Candida sepsis 17.74 16.31 14 89367 1639 90537427
Cheyne-Stokes respiration 17.72 16.31 6 89375 113 90538953
Aborted pregnancy 17.67 16.31 5 89376 50 90539016
Parvovirus infection 17.65 16.31 9 89372 490 90538576
Cardiac ventricular thrombosis 17.60 16.31 12 89369 1122 90537944
Skin discolouration 17.54 16.31 11 89370 44304 90494762
Sinus congestion 17.45 16.31 3 89378 27421 90511645
Splenic marginal zone lymphoma 17.41 16.31 5 89376 53 90539013
Chronic myeloid leukaemia 17.37 16.31 17 89364 2647 90536419
Oral pain 17.31 16.31 71 89310 32612 90506454
Beta 2 microglobulin decreased 17.27 16.31 4 89377 16 90539050
Meningitis bacterial 17.27 16.31 14 89367 1703 90537363
Delayed puberty 17.25 16.31 6 89375 123 90538943
Blood disorder 17.21 16.31 29 89352 7761 90531305
Respiratory tract infection fungal 17.20 16.31 9 89372 517 90538549
Cardiac failure acute 17.16 16.31 37 89344 11892 90527174
Ocular lymphoma 17.11 16.31 6 89375 126 90538940
Pneumothorax spontaneous 17.08 16.31 11 89370 934 90538132
Cachexia 17.08 16.31 27 89354 6851 90532215
Eye swelling 17.06 16.31 4 89377 29382 90509684
Ocular hyperaemia 17.05 16.31 6 89375 33792 90505274
Graft versus host disease in skin 17.02 16.31 20 89361 3833 90535233
Acute motor-sensory axonal neuropathy 16.96 16.31 8 89373 367 90538699
C-reactive protein increased 16.93 16.31 107 89274 181282 90357784
Pulmonary vascular disorder 16.90 16.31 8 89373 370 90538696
Axonal neuropathy 16.90 16.31 12 89369 1197 90537869
Bone marrow necrosis 16.90 16.31 6 89375 131 90538935
Perirectal abscess 16.89 16.31 11 89370 952 90538114
Norovirus test positive 16.86 16.31 7 89374 236 90538830
Haematocolpos 16.85 16.31 5 89376 60 90539006
Hypercreatininaemia 16.74 16.31 10 89371 743 90538323
Embolism 16.72 16.31 32 89349 9449 90529617
Bacterial translocation 16.71 16.31 10 89371 746 90538320
Gallbladder enlargement 16.69 16.31 11 89370 972 90538094
Post-acute COVID-19 syndrome 16.65 16.31 12 89369 1225 90537841
Central nervous system leukaemia 16.64 16.31 7 89374 244 90538822
Central nervous system lesion 16.62 16.31 36 89345 11610 90527456
Malignant neoplasm of orbit 16.54 16.31 4 89377 20 90539046
Cardiac disorder 16.53 16.31 19 89362 56853 90482213
Rectal fissure 16.49 16.31 10 89371 764 90538302
Ulcer haemorrhage 16.49 16.31 3 89378 26318 90512748
Cerebral aspergillosis 16.45 16.31 9 89372 566 90538500
Diabetes insipidus 16.44 16.31 18 89363 3194 90535872
Marginal zone lymphoma recurrent 16.38 16.31 4 89377 21 90539045
Haemobilia 16.37 16.31 6 89375 144 90538922
Chemotherapeutic drug level above therapeutic 16.34 16.31 5 89376 67 90538999

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 5891.62 14.15 4520 113397 181183 42322235
Disease progression 2530.59 14.15 2509 115408 141147 42362271
Neutropenia 1666.53 14.15 2381 115536 197050 42306368
Myelosuppression 1059.33 14.15 885 117032 39576 42463842
Diffuse large B-cell lymphoma recurrent 1040.89 14.15 421 117496 4465 42498953
Mucosal inflammation 752.52 14.15 800 117117 48574 42454844
Haematotoxicity 703.50 14.15 416 117501 10569 42492849
Second primary malignancy 677.84 14.15 387 117530 9188 42494230
Off label use 620.87 14.15 3424 114493 634911 41868507
Neoplasm progression 586.06 14.15 548 117369 28452 42474966
Hepatitis B reactivation 575.15 14.15 272 117645 4306 42499112
Tumour lysis syndrome 566.43 14.15 479 117438 21752 42481666
Pancytopenia 563.27 14.15 1097 116820 116646 42386772
Febrile bone marrow aplasia 515.60 14.15 332 117585 9849 42493569
Thrombocytopenia 500.03 14.15 1401 116516 188878 42314540
Hepatitis B 490.48 14.15 277 117640 6434 42496984
Myelodysplastic syndrome 485.10 14.15 443 117474 22302 42481116
Product use in unapproved indication 483.52 14.15 1357 116560 183099 42320319
Venoocclusive liver disease 480.32 14.15 319 117598 9983 42493435
Posterior reversible encephalopathy syndrome 475.70 14.15 345 117572 12476 42490942
Bone marrow failure 453.05 14.15 507 117410 32586 42470832
Acute myeloid leukaemia 435.12 14.15 413 117504 21843 42481575
Therapy partial responder 427.04 14.15 390 117527 19631 42483787
Cytokine release syndrome 407.42 14.15 557 117360 43970 42459448
Septic shock 369.30 14.15 796 117121 90876 42412542
Product dose omission issue 362.56 14.15 15 117902 154350 42349068
Cytopenia 356.01 14.15 332 117585 17165 42486253
Diffuse large B-cell lymphoma refractory 354.12 14.15 151 117766 1846 42501572
Fall 339.55 14.15 113 117804 234407 42269011
Hypofibrinogenaemia 336.50 14.15 145 117772 1822 42501596
Sepsis 318.23 14.15 1240 116677 198094 42305324
Disease recurrence 308.01 14.15 395 117522 29283 42474135
Leukopenia 305.50 14.15 653 117264 74093 42429325
Neuropathy peripheral 304.18 14.15 787 117130 101066 42402352
Pyrexia 291.55 14.15 1974 115943 392068 42111350
Cytomegalovirus chorioretinitis 290.92 14.15 173 117744 4438 42498980
Progressive multifocal leukoencephalopathy 290.55 14.15 247 117670 11289 42492129
Fatigue 269.24 14.15 498 117419 435143 42068275
Arthralgia 268.45 14.15 116 117801 205122 42298296
Cardiotoxicity 266.31 14.15 196 117721 7249 42496169
Hypogammaglobulinaemia 260.12 14.15 235 117682 11656 42491762
Hypertriglyceridaemia 259.51 14.15 219 117698 9907 42493511
Blood lactate dehydrogenase increased 251.77 14.15 335 117582 25746 42477672
Rash 251.14 14.15 238 117679 276716 42226702
Lymphadenopathy 250.37 14.15 380 117537 32985 42470433
Dizziness 240.58 14.15 202 117715 249052 42254366
Dyspnoea 239.52 14.15 546 117371 442075 42061343
Acute lymphocytic leukaemia recurrent 231.60 14.15 138 117779 3553 42499865
Neutrophil count decreased 228.60 14.15 527 117390 62888 42440530
B-cell lymphoma recurrent 221.16 14.15 85 117832 777 42502641
Neutropenic sepsis 221.04 14.15 246 117671 15700 42487718
Myocardial infarction 215.37 14.15 41 117876 123968 42379450
Pneumocystis jirovecii pneumonia 215.26 14.15 305 117612 24876 42478542
Diffuse large B-cell lymphoma 215.02 14.15 191 117726 9263 42494155
Pruritus 214.93 14.15 128 117789 188643 42314775
Pain 209.75 14.15 221 117696 244627 42258791
Aspergillus infection 207.05 14.15 237 117680 15600 42487818
Neurotoxicity 200.00 14.15 285 117632 23366 42480052
Hyperbilirubinaemia 197.54 14.15 264 117653 20371 42483047
Inappropriate schedule of product administration 196.49 14.15 19 117898 95883 42407535
Acquired gene mutation 192.70 14.15 92 117825 1488 42501930
Neoplasm recurrence 189.79 14.15 109 117808 2615 42500803
Malignant neoplasm progression 187.16 14.15 692 117225 107708 42395710
Mantle cell lymphoma recurrent 183.53 14.15 78 117839 945 42502473
Death 183.38 14.15 679 117238 470506 42032912
Malaise 182.19 14.15 191 117726 211965 42291453
Candida infection 180.66 14.15 259 117658 21351 42482067
Anxiety 178.73 14.15 53 117864 118507 42384911
Lymphoma 173.33 14.15 206 117711 14115 42489303
Muscle spasms 171.22 14.15 19 117898 86025 42417393
Insomnia 170.87 14.15 57 117860 118196 42385222
Stomatitis 170.17 14.15 408 117509 49921 42453497
Somnolence 168.71 14.15 90 117827 141015 42362403
Joint swelling 165.19 14.15 5 117912 68017 42435401
Bacteraemia 164.02 14.15 268 117649 24772 42478646
Venoocclusive disease 162.86 14.15 113 117804 3802 42499616
Rhabdomyolysis 153.30 14.15 18 117899 78001 42425417
Hospitalisation 151.53 14.15 15 117902 74315 42429103
Peripheral swelling 150.15 14.15 33 117884 90237 42413181
Post transplant lymphoproliferative disorder 149.87 14.15 154 117763 8966 42494452
Leukoencephalopathy 145.50 14.15 116 117801 4838 42498580
Depression 142.21 14.15 65 117852 111298 42392120
Intentional product misuse 138.86 14.15 8 117909 61892 42441526
Polyneuropathy 134.97 14.15 209 117708 18452 42484966
Drug ineffective 133.31 14.15 2462 115455 627735 41875683
Weight increased 125.95 14.15 71 117846 107912 42395506
Epstein-Barr virus infection 124.61 14.15 144 117773 9574 42493844
Myelopathy 123.91 14.15 85 117832 2806 42500612
Confusional state 123.47 14.15 170 117747 167427 42335991
Blood pressure increased 123.29 14.15 64 117853 101864 42401554
Central nervous system lymphoma 122.87 14.15 65 117852 1320 42502098
Pain in extremity 122.13 14.15 142 117775 150462 42352956
Diarrhoea 120.85 14.15 764 117153 460085 42043333
Loss of personal independence in daily activities 119.74 14.15 4 117913 49812 42453606
Injection site pain 119.56 14.15 11 117906 57787 42445631
Neutropenic colitis 119.33 14.15 99 117818 4371 42499047
Suicidal ideation 118.93 14.15 3 117914 48158 42455260
Coombs positive haemolytic anaemia 118.24 14.15 61 117856 1174 42502244
Nasopharyngitis 116.99 14.15 43 117874 83953 42419465
Herpes simplex 116.93 14.15 120 117797 6975 42496443
Asthma 116.12 14.15 17 117900 62297 42441121
Overdose 116.04 14.15 74 117843 105190 42398228
Haemophagocytic lymphohistiocytosis 115.25 14.15 192 117725 18030 42485388
Cytomegalovirus infection reactivation 114.70 14.15 148 117769 11030 42492388
Infection 113.92 14.15 611 117306 111457 42391961
Chest pain 111.58 14.15 133 117784 139397 42364021
Bronchopulmonary aspergillosis 111.41 14.15 196 117721 19233 42484185
Chronic obstructive pulmonary disease 111.38 14.15 20 117897 63094 42440324
Feeling abnormal 109.21 14.15 29 117888 69757 42433661
Coronary artery disease 109.06 14.15 11 117906 53709 42449709
Hepatotoxicity 107.47 14.15 224 117693 24943 42478475
White blood cell count decreased 106.90 14.15 594 117323 109802 42393616
Incorrect dose administered 104.61 14.15 12 117905 52962 42450456
Myalgia 103.92 14.15 69 117848 96011 42407407
Rheumatoid arthritis 103.47 14.15 3 117914 42437 42460981
Musculoskeletal stiffness 102.59 14.15 18 117899 57747 42445671
Lymphopenia 101.68 14.15 200 117717 21363 42482055
Lymphadenitis 101.00 14.15 71 117846 2440 42500978
Therapy non-responder 99.94 14.15 350 117567 53009 42450409
Sleep disorder 99.88 14.15 9 117908 48086 42455332
Immune effector cell-associated neurotoxicity syndrome 98.22 14.15 126 117791 9335 42494083
Drug interaction 98.19 14.15 393 117524 266606 42236812
Blood fibrinogen decreased 98.14 14.15 59 117858 1544 42501874
Fungal infection 97.98 14.15 187 117730 19535 42483883
Hyperhidrosis 97.89 14.15 65 117852 90447 42412971
Gastrointestinal toxicity 97.73 14.15 84 117833 3895 42499523
Oedema peripheral 97.23 14.15 141 117776 135935 42367483
Tremor 96.50 14.15 76 117841 96853 42406565
Psoriasis 96.00 14.15 11 117906 48593 42454825
Cerebrovascular accident 94.45 14.15 78 117839 97082 42406336
Drug resistance 94.30 14.15 257 117660 33991 42469427
Acute lymphocytic leukaemia 93.70 14.15 77 117840 3354 42500064
Cytomegalovirus infection 92.55 14.15 246 117671 32060 42471358
Pneumonia fungal 92.13 14.15 120 117797 9026 42494392
Anaemia 91.98 14.15 1181 116736 279097 42224321
COVID-19 90.00 14.15 589 117328 115359 42388059
Drug hypersensitivity 86.86 14.15 88 117829 99301 42404117
Cardiac failure congestive 86.63 14.15 66 117851 85536 42417882
Skin exfoliation 85.69 14.15 8 117909 41545 42461873
Suicide attempt 84.91 14.15 13 117904 46087 42457331
Cerebral venous thrombosis 84.35 14.15 46 117871 995 42502423
Memory impairment 84.22 14.15 18 117899 50204 42453214
Abdominal discomfort 84.17 14.15 52 117865 75203 42428215
Escherichia sepsis 83.68 14.15 91 117826 5656 42497762
Wheezing 83.40 14.15 24 117893 54757 42448661
Headache 82.59 14.15 361 117556 239008 42264410
Aggression 82.39 14.15 12 117905 44151 42459267
Back pain 81.16 14.15 169 117748 141607 42361811
Sweat gland tumour 80.81 14.15 34 117883 401 42503017
Hallucination 80.81 14.15 29 117888 57478 42445940
Lymphoma transformation 80.57 14.15 36 117881 496 42502922
Gait disturbance 79.83 14.15 92 117825 97908 42405510
Blood creatine phosphokinase increased 79.69 14.15 18 117899 48320 42455098
Strongyloidiasis 79.37 14.15 70 117847 3361 42500057
Agranulocytosis 78.64 14.15 224 117693 30388 42473030
Chest discomfort 78.31 14.15 39 117878 63577 42439841
Osteonecrosis 78.27 14.15 150 117767 15715 42487703
Pseudomonal bacteraemia 76.62 14.15 59 117858 2337 42501081
Minimal residual disease 75.25 14.15 36 117881 585 42502833
Epstein-Barr virus associated lymphoma 75.18 14.15 43 117874 1023 42502395
Escherichia infection 74.65 14.15 122 117795 11274 42492144
Staphylococcal sepsis 74.50 14.15 122 117795 11292 42492126
Blood glucose increased 73.07 14.15 58 117859 73641 42429777
Cardiomyopathy 72.87 14.15 163 117754 19047 42484371
Glioma 72.69 14.15 33 117884 473 42502945
Systemic mycosis 72.47 14.15 57 117860 2330 42501088
Sedation 71.33 14.15 3 117914 30472 42472946
JC virus infection 70.92 14.15 62 117855 2942 42500476
Mucormycosis 70.83 14.15 93 117824 7050 42496368
Asthenia 70.57 14.15 471 117446 280322 42223096
Systemic candida 70.18 14.15 80 117837 5239 42498179
Multiple organ dysfunction syndrome 69.92 14.15 484 117433 96551 42406867
Erythema 69.86 14.15 121 117796 108672 42394746
Klebsiella infection 69.78 14.15 118 117799 11214 42492204
Aplasia 69.32 14.15 76 117841 4767 42498651
Heart rate decreased 67.97 14.15 10 117907 36522 42466896
Malignant transformation 67.77 14.15 39 117878 939 42502479
Ileus paralytic 64.46 14.15 92 117825 7549 42495869
Hepatic failure 63.78 14.15 241 117676 37859 42465559
Loss of consciousness 62.75 14.15 99 117818 92255 42411163
Adenovirus infection 61.93 14.15 85 117832 6724 42496694
Eczema 61.89 14.15 10 117907 34076 42469342
Weight decreased 61.59 14.15 331 117586 207617 42295801
Adverse drug reaction 61.58 14.15 14 117903 37420 42465998
B-cell lymphoma refractory 60.64 14.15 23 117894 202 42503216
Cerebral venous sinus thrombosis 60.33 14.15 33 117884 718 42502700
Coagulopathy 59.70 14.15 165 117752 21997 42481421
Hepatosplenomegaly 59.65 14.15 69 117848 4591 42498827
Wrong technique in product usage process 59.05 14.15 22 117895 42613 42460805
Klebsiella sepsis 58.31 14.15 53 117864 2648 42500770
Arthritis 57.77 14.15 22 117895 42043 42461375
Arthropathy 57.69 14.15 7 117910 29590 42473828
Intestinal perforation 57.61 14.15 106 117811 10768 42492650
Abdominal pain upper 57.61 14.15 87 117830 82522 42420896
Bacterial sepsis 57.58 14.15 80 117837 6402 42497016
Respiratory failure 56.85 14.15 573 117344 127559 42375859
Nightmare 56.80 14.15 3 117914 25009 42478409
West Nile viral infection 56.78 14.15 34 117883 883 42502535
Blood pressure systolic increased 56.06 14.15 6 117911 27962 42475456
Serotonin syndrome 55.99 14.15 4 117913 25841 42477577
Contusion 55.95 14.15 23 117894 41962 42461456
Pneumonia viral 55.91 14.15 64 117853 4210 42499208
Enterovirus infection 55.38 14.15 38 117879 1255 42502163
Haemolysis 55.31 14.15 97 117820 9492 42493926
Ill-defined disorder 54.92 14.15 132 117785 16164 42487254
Acute lymphocytic leukaemia refractory 54.70 14.15 19 117898 126 42503292
Platelet count decreased 54.58 14.15 605 117312 137976 42365442
Colitis ulcerative 54.07 14.15 5 117912 26170 42477248
Gastritis bacterial 53.76 14.15 24 117893 330 42503088
Viral haemorrhagic cystitis 53.56 14.15 43 117874 1811 42501607
Blood pressure fluctuation 53.35 14.15 6 117911 26902 42476516
Gastrooesophageal reflux disease 53.33 14.15 29 117888 44994 42458424
Infection reactivation 53.24 14.15 46 117871 2148 42501270
Bradycardia 53.13 14.15 97 117820 85387 42418031
Plasma cell myeloma 53.02 14.15 33 117884 47545 42455873
Swelling 52.17 14.15 45 117872 54840 42448578
Device related thrombosis 51.57 14.15 38 117879 1407 42502011
Treatment noncompliance 51.24 14.15 20 117897 37652 42465766
Subdural hygroma 51.14 14.15 25 117892 427 42502991
Staphylococcal bacteraemia 51.04 14.15 102 117815 11019 42492399
Bone marrow necrosis 50.86 14.15 22 117895 279 42503139
Hypertransaminasaemia 50.22 14.15 91 117826 9136 42494282
Colitis 50.06 14.15 258 117659 46314 42457104
Hypoglycaemia 50.02 14.15 55 117862 59799 42443619
Hot flush 49.77 14.15 3 117914 22348 42481070
Therapy interrupted 49.51 14.15 3 117914 22247 42481171
Bacillus bacteraemia 49.50 14.15 19 117898 173 42503245
Hyperkalaemia 49.38 14.15 92 117825 80366 42423052
Clostridium difficile colitis 49.32 14.15 150 117767 21102 42482316
Mobility decreased 49.26 14.15 18 117899 35288 42468130
Bone marrow disorder 48.93 14.15 42 117875 1944 42501474
Vision blurred 48.68 14.15 46 117871 53653 42449765
Haematochezia 48.50 14.15 54 117863 58382 42445036
Pseudomonas infection 48.41 14.15 124 117793 15799 42487619
Diabetes mellitus 48.28 14.15 57 117860 60030 42443388
Clostridium difficile infection 48.04 14.15 155 117762 22504 42480914
Glioblastoma multiforme 47.72 14.15 30 117887 852 42502566
Neuroleptic malignant syndrome 47.46 14.15 3 117914 21469 42481949
Cystitis haemorrhagic 47.38 14.15 78 117839 7251 42496167
Blood culture positive 47.35 14.15 64 117853 4989 42498429
Bacillus infection 47.08 14.15 28 117889 718 42502700
Epstein-Barr virus associated lymphoproliferative disorder 47.08 14.15 45 117872 2398 42501020
Dry mouth 46.78 14.15 26 117891 39853 42463565
Dysgeusia 46.75 14.15 18 117899 34171 42469247
Adenoviral hepatitis 46.12 14.15 25 117892 534 42502884
Blood cholesterol increased 46.04 14.15 9 117908 26732 42476686
Illness 45.97 14.15 7 117910 24923 42478495
COVID-19 pneumonia 45.96 14.15 148 117769 21465 42481953
Ejection fraction decreased 45.84 14.15 150 117767 21937 42481481
Transient ischaemic attack 45.74 14.15 18 117899 33721 42469697
Heart rate increased 45.55 14.15 48 117869 53207 42450211
Palpitations 45.48 14.15 44 117873 50753 42452665
Inappropriate antidiuretic hormone secretion 45.39 14.15 124 117793 16417 42487001
Nervous system disorder 45.31 14.15 127 117790 17068 42486350
Adverse event 45.09 14.15 6 117911 23634 42479784
Superior sagittal sinus thrombosis 44.99 14.15 21 117896 322 42503096
Cerebral toxoplasmosis 44.96 14.15 41 117876 2057 42501361
Acute myelomonocytic leukaemia 44.80 14.15 18 117899 187 42503231
Syncope 44.76 14.15 134 117783 99272 42404146
Encephalopathy 44.43 14.15 229 117688 41104 42462314
Angiocentric lymphoma 44.26 14.15 24 117893 513 42502905
Balance disorder 44.15 14.15 40 117877 47605 42455813
Pneumonia aspiration 44.12 14.15 44 117873 50034 42453384
Transformation to acute myeloid leukaemia 43.87 14.15 31 117886 1074 42502344
Psoriatic arthropathy 43.84 14.15 8 117909 24959 42478459
Cardio-respiratory arrest 43.59 14.15 59 117858 58577 42444841
Urticaria 43.39 14.15 87 117830 73949 42429469
Obstructive airways disorder 43.34 14.15 8 117909 24751 42478667
Stomatococcal infection 42.73 14.15 18 117899 213 42503205
Nausea 42.50 14.15 808 117109 395991 42107427
Follicular lymphoma 42.29 14.15 22 117895 431 42502987
Primitive neuroectodermal tumour 42.21 14.15 14 117903 79 42503339
Depressed mood 42.14 14.15 7 117910 23377 42480041
Gastrosplenic fistula 42.06 14.15 13 117904 56 42503362
Hepatopulmonary syndrome 42.01 14.15 15 117902 109 42503309
Frequent bowel movements 41.88 14.15 5 117912 21402 42482016
Hepatitis viral 41.87 14.15 27 117890 802 42502616
Accidental exposure to product 41.85 14.15 4 117913 20389 42483029
Injury 41.77 14.15 6 117911 22310 42481108
Intussusception 41.52 14.15 26 117891 733 42502685
Blood stem cell transplant failure 41.40 14.15 22 117895 451 42502967
Injection site erythema 41.34 14.15 4 117913 20191 42483227
Condition aggravated 41.33 14.15 492 117425 260262 42243156
Road traffic accident 41.23 14.15 3 117914 19090 42484328
Fluid retention 41.04 14.15 18 117899 31601 42471817
Flushing 40.82 14.15 26 117891 37002 42466416
Left ventricular dysfunction 40.75 14.15 95 117822 11406 42492012
Gene mutation 40.53 14.15 36 117881 1745 42501673
Hypothyroidism 40.50 14.15 19 117898 32065 42471353
Autoimmune lymphoproliferative syndrome 40.44 14.15 17 117900 200 42503218
Antithrombin III decreased 40.07 14.15 23 117894 551 42502867
Influenza 40.03 14.15 69 117848 62106 42441312
Babesiosis 39.35 14.15 17 117900 215 42503203
Human polyomavirus infection 39.31 14.15 31 117886 1272 42502146
Unevaluable event 39.29 14.15 23 117894 34265 42469153
Rash pruritic 39.28 14.15 22 117895 33581 42469837
Refractory cancer 39.18 14.15 16 117901 174 42503244
Cytogenetic abnormality 39.02 14.15 27 117890 904 42502514
Visual impairment 39.00 14.15 37 117880 43076 42460342
Amnesia 38.83 14.15 15 117902 28422 42474996
Acute monocytic leukaemia 38.76 14.15 20 117897 385 42503033
Congenital cardiovascular anomaly 38.62 14.15 16 117901 181 42503237
Cystitis viral 38.45 14.15 30 117887 1212 42502206
Medication error 38.34 14.15 22 117895 33132 42470286
Drug clearance decreased 38.01 14.15 38 117879 2140 42501278
Haematopoietic stem cell mobilisation 37.92 14.15 19 117898 343 42503075
Marginal zone lymphoma recurrent 37.55 14.15 12 117905 59 42503359
International normalised ratio increased 37.31 14.15 47 117870 48121 42455297
Decreased appetite 37.25 14.15 348 117569 192789 42310629
Drug reaction with eosinophilia and systemic symptoms 37.02 14.15 37 117880 42038 42461380
Leukaemia recurrent 36.99 14.15 35 117882 1841 42501577
Swollen tongue 36.86 14.15 7 117910 21224 42482194
Rectal haemorrhage 36.79 14.15 50 117867 49556 42453862
Retinal haemorrhage 36.75 14.15 61 117856 5709 42497709
Vertigo 36.66 14.15 25 117892 34322 42469096
Blood creatinine increased 36.60 14.15 168 117749 109835 42393583
Central nervous system leukaemia 36.44 14.15 19 117898 374 42503044
Deafness neurosensory 35.95 14.15 48 117869 3698 42499720
Bladder cancer 35.91 14.15 3 117914 17044 42486374
Electrocardiogram QT prolonged 35.89 14.15 48 117869 47897 42455521
Pleural effusion 35.88 14.15 419 117498 96747 42406671
Juvenile melanoma benign 35.85 14.15 12 117905 70 42503348
Peripheral sensorimotor neuropathy 35.72 14.15 35 117882 1923 42501495
Injection site swelling 35.71 14.15 3 117914 16970 42486448
Agitation 35.65 14.15 78 117839 64236 42439182
Product quality issue 35.42 14.15 4 117913 17878 42485540
Neoplasm 35.36 14.15 63 117854 6242 42497176
Small intestinal perforation 35.08 14.15 42 117875 2899 42500519
Hypertension 35.00 14.15 295 117622 166909 42336509
Delirium 35.00 14.15 57 117860 52462 42450956
Coma 34.87 14.15 59 117858 53495 42449923
Gallbladder oedema 34.83 14.15 16 117901 236 42503182
Haemorrhage 34.78 14.15 72 117845 60491 42442927
Hepatitis E 34.53 14.15 43 117874 3091 42500327
Chromosome analysis abnormal 34.49 14.15 15 117902 193 42503225
Angioedema 34.44 14.15 40 117877 42437 42460981
Benign prostatic hyperplasia 34.37 14.15 8 117909 21044 42482374
Psychotic disorder 34.32 14.15 19 117898 29189 42474229
Burning sensation 34.28 14.15 8 117909 21005 42482413
Cardiac arrest 34.01 14.15 171 117746 109149 42394269
Skin discolouration 33.99 14.15 8 117909 20882 42482536
Parainfluenzae virus infection 33.92 14.15 46 117871 3597 42499821
Toxicity to various agents 33.79 14.15 439 117478 228697 42274721
Peripheral T-cell lymphoma unspecified 33.76 14.15 21 117896 585 42502833
Sleep apnoea syndrome 33.75 14.15 9 117908 21599 42481819
Aspiration bone marrow abnormal 33.52 14.15 13 117904 122 42503296
Dyspepsia 33.46 14.15 39 117878 41313 42462105
Central nervous system neoplasm 33.28 14.15 12 117905 90 42503328
Disorientation 33.18 14.15 31 117886 36358 42467060
Disturbance in attention 32.88 14.15 21 117896 29845 42473573
Nephrolithiasis 32.85 14.15 32 117885 36798 42466620
Localised infection 32.76 14.15 8 117909 20365 42483053
Recurrent cancer 32.59 14.15 31 117886 1642 42501776
Thrombosis 32.55 14.15 90 117827 68421 42434997
Rhabdomyosarcoma recurrent 32.53 14.15 13 117904 133 42503285
Escherichia bacteraemia 32.21 14.15 54 117863 5095 42498323
Fat embolism syndrome 32.19 14.15 11 117906 69 42503349
Bone marrow infiltration 32.02 14.15 15 117902 232 42503186
Dyspnoea exertional 31.96 14.15 56 117861 50092 42453326
Metastases to spleen 31.85 14.15 19 117898 490 42502928
Obesity 31.81 14.15 4 117913 16455 42486963
Xanthogranuloma 31.79 14.15 11 117906 72 42503346
Enterocolitis infectious 31.70 14.15 33 117884 1950 42501468
Ganglioneuroblastoma 31.63 14.15 9 117908 27 42503391
Troponin increased 31.61 14.15 7 117910 19055 42484363
Stevens-Johnson syndrome 31.46 14.15 11 117906 22167 42481251
Pulmonary vascular disorder 31.32 14.15 21 117896 667 42502751
Administration site extravasation 31.27 14.15 22 117895 757 42502661
Pulmonary arteriopathy 31.04 14.15 11 117906 78 42503340
Cerebral aspergillosis 31.00 14.15 31 117886 1746 42501672
Abdominal neoplasm 30.96 14.15 18 117899 442 42502976
Lymphocytosis 30.88 14.15 40 117877 2991 42500427
Graft versus host disease 30.71 14.15 92 117825 12833 42490585
Hallucination, visual 30.56 14.15 10 117907 21010 42482408
Hallucination, auditory 30.28 14.15 3 117914 14861 42488557
Acute hepatic failure 30.24 14.15 110 117807 16963 42486455
Prostate cancer 30.17 14.15 48 117869 44595 42458823
Withdrawal syndrome 30.05 14.15 3 117914 14772 42488646
Metastatic lymphoma 30.04 14.15 17 117900 396 42503022
B-cell lymphoma 30.04 14.15 51 117866 4862 42498556
Injection site reaction 29.96 14.15 4 117913 15717 42487701
Delusion 29.94 14.15 3 117914 14731 42488687
Retroperitoneal lymphadenopathy 29.91 14.15 24 117893 1010 42502408
Enterococcal infection 29.85 14.15 87 117830 11952 42491466
Accidental overdose 29.74 14.15 21 117896 28309 42475109
Musculoskeletal pain 29.70 14.15 29 117888 33311 42470107
Labelled drug-drug interaction medication error 29.61 14.15 4 117913 15578 42487840
Brain abscess 29.61 14.15 47 117870 4237 42499181
Pneumonitis 29.38 14.15 207 117710 41511 42461907
Blood bilirubin increased 29.37 14.15 209 117708 42043 42461375
Hepatosplenic candidiasis 29.29 14.15 14 117903 227 42503191
Post-acute COVID-19 syndrome 29.08 14.15 17 117900 422 42502996
Hepatomegaly 29.06 14.15 85 117832 11700 42491718
Humoral immune defect 29.01 14.15 16 117901 354 42503064
Hepatocellular injury 28.88 14.15 136 117781 23542 42479876
Lower respiratory tract infection fungal 28.78 14.15 19 117898 588 42502830
Multiple-drug resistance 28.75 14.15 63 117854 7259 42496159
Pathogen resistance 28.64 14.15 83 117834 11367 42492051
Mass 28.60 14.15 70 117847 8669 42494749
Nephropathy toxic 28.58 14.15 107 117810 16731 42486687
Azoospermia 28.48 14.15 18 117899 516 42502902
Arrhythmogenic right ventricular dysplasia 28.37 14.15 9 117908 43 42503375
Myelitis transverse 28.24 14.15 26 117891 1321 42502097
Migraine with aura 28.02 14.15 22 117895 897 42502521
Drug ineffective for unapproved indication 27.94 14.15 221 117696 45942 42457476
Head injury 27.87 14.15 11 117906 20571 42482847
Restlessness 27.77 14.15 24 117893 29225 42474193
Atypical haemolytic uraemic syndrome 27.73 14.15 18 117899 541 42502877
Neurofibrosarcoma 27.71 14.15 9 117908 47 42503371
Varicella zoster virus infection 27.56 14.15 35 117882 2566 42500852
Lung disorder 27.49 14.15 57 117860 47866 42455552
Peripheral sensory neuropathy 27.43 14.15 69 117848 8693 42494725
Neuroblastoma recurrent 27.41 14.15 16 117901 396 42503022
Astrocytoma 27.41 14.15 13 117904 207 42503211
Discomfort 27.40 14.15 18 117899 25201 42478217
Device related infection 27.36 14.15 120 117797 20159 42483259
Pneumonia klebsiella 27.32 14.15 45 117872 4184 42499234
Synovitis 27.31 14.15 5 117912 15562 42487856
Lung infiltration 27.25 14.15 93 117824 13896 42489522
Fibrinous bronchitis 27.23 14.15 11 117906 116 42503302
Arteriosclerosis coronary artery 26.95 14.15 9 117908 18668 42484750
Meningitis cryptococcal 26.92 14.15 39 117878 3244 42500174
Delayed puberty 26.80 14.15 13 117904 218 42503200
Neurological decompensation 26.78 14.15 42 117875 3747 42499671
Erectile dysfunction 26.77 14.15 18 117899 24895 42478523
Orthostatic hypotension 26.76 14.15 27 117890 30543 42472875
Dehydration 26.65 14.15 257 117660 141510 42361908
Productive cough 26.59 14.15 65 117852 51502 42451916
Peripheral motor neuropathy 26.46 14.15 32 117885 2232 42501186
Limb injury 26.41 14.15 4 117913 14301 42489117
Haemoptysis 26.41 14.15 55 117862 46112 42457306
Blood HIV RNA increased 26.38 14.15 27 117890 1564 42501854
Cerebral thrombosis 26.23 14.15 22 117895 986 42502432
Blood glucose decreased 26.20 14.15 4 117913 14215 42489203
Human rhinovirus test positive 26.17 14.15 14 117903 291 42503127
Respiratory arrest 26.17 14.15 24 117893 28400 42475018
Central nervous system fungal infection 26.00 14.15 16 117901 437 42502981
Therapy cessation 25.98 14.15 12 117905 20438 42482980
Ureteric compression 25.91 14.15 14 117903 297 42503121
Cardiac dysfunction 25.88 14.15 39 117878 3360 42500058
Immunosuppression 25.87 14.15 66 117851 8387 42495031
Atrial fibrillation 25.84 14.15 254 117663 139339 42364079
Skin laceration 25.80 14.15 4 117913 14054 42489364
Influenza like illness 25.79 14.15 30 117887 31810 42471608
Ototoxicity 25.78 14.15 32 117885 2293 42501125
Disorder of orbit 25.77 14.15 10 117907 94 42503324
Encephalitis enteroviral 25.71 14.15 12 117905 184 42503234
Rib fracture 25.70 14.15 7 117910 16564 42486854
Plasmablastic lymphoma 25.64 14.15 18 117899 617 42502801
Diabetic ketoacidosis 25.63 14.15 15 117902 22352 42481066
Iron deficiency anaemia 25.62 14.15 3 117914 13036 42490382
Jugular vein thrombosis 25.36 14.15 30 117887 2044 42501374
Plasma cell myeloma refractory 25.34 14.15 25 117892 1385 42502033
Extrapyramidal disorder 25.32 14.15 7 117910 16405 42487013
Chylothorax 25.27 14.15 23 117894 1151 42502267
Pleuroparenchymal fibroelastosis 25.26 14.15 11 117906 142 42503276
Hepatitis 25.12 14.15 145 117772 27155 42476263
Oesophageal candidiasis 25.04 14.15 51 117866 5584 42497834
Scedosporium infection 25.04 14.15 26 117891 1532 42501886
Neoplasm malignant 25.02 14.15 16 117901 22727 42480691
Pancreatitis 25.02 14.15 205 117712 43063 42460355
Hypersomnia 25.00 14.15 5 117912 14613 42488805
Ameloblastoma 24.97 14.15 10 117907 103 42503315
HCoV-HKU1 infection 24.92 14.15 8 117909 40 42503378
Granulocyte count decreased 24.87 14.15 26 117891 1544 42501874
Diabetes mellitus inadequate control 24.83 14.15 6 117911 15384 42488034
B-lymphocyte count decreased 24.78 14.15 20 117897 849 42502569
Genotoxicity 24.76 14.15 8 117909 41 42503377
Bronchitis 24.73 14.15 59 117858 47142 42456276
Medulloblastoma recurrent 24.71 14.15 10 117907 106 42503312
Hepatic candidiasis 24.68 14.15 9 117908 70 42503348
End stage renal disease 24.68 14.15 101 117816 16457 42486961
Neck pain 24.61 14.15 28 117889 29986 42473432
Hereditary motor and sensory neuropathy 24.61 14.15 7 117910 21 42503397
Epstein-Barr viraemia 24.57 14.15 31 117886 2258 42501160
Cerebral candidiasis 24.46 14.15 9 117908 72 42503346
Cerebral cavernous malformation 24.44 14.15 8 117909 43 42503375
Vaccination failure 24.44 14.15 25 117892 1447 42501971
Hyperleukocytosis 24.39 14.15 33 117884 2575 42500843
Cardiogenic shock 24.39 14.15 38 117879 35602 42467816
Blister 24.38 14.15 24 117893 27466 42475952
Molluscum contagiosum 24.11 14.15 14 117903 343 42503075
Respiratory depression 24.08 14.15 11 117906 18857 42484561
Feeling hot 23.87 14.15 18 117899 23464 42479954
Disseminated cryptococcosis 23.80 14.15 28 117889 1897 42501521
Liver function test abnormal 23.66 14.15 33 117884 32358 42471060
Transaminases increased 23.64 14.15 164 117753 32721 42470697
Cytomegalovirus hepatitis 23.62 14.15 16 117901 517 42502901
Intestinal atresia 23.54 14.15 9 117908 81 42503337
Pneumocystis jirovecii infection 23.48 14.15 34 117883 2826 42500592
Wound 23.42 14.15 9 117908 17108 42486310
Lactic acidosis 23.38 14.15 57 117860 45204 42458214
Blood urea increased 23.37 14.15 34 117883 32759 42470659
Lentigo 23.37 14.15 19 117898 815 42502603
Bacillus test positive 23.35 14.15 9 117908 83 42503335
Haemoglobin abnormal 23.34 14.15 46 117871 4918 42498500
Body height below normal 23.30 14.15 12 117905 230 42503188
Hypotension 23.28 14.15 539 117378 257092 42246326
Dry eye 23.21 14.15 7 117910 15499 42487919
Herpes simplex encephalitis 23.16 14.15 14 117903 370 42503048
Gastrointestinal wall thickening 23.15 14.15 27 117890 1812 42501606
Melaena 23.15 14.15 45 117872 38701 42464717
Metastases to bone marrow 23.12 14.15 16 117901 536 42502882
Loss of CAR T-cell persistence 23.06 14.15 7 117910 28 42503390
Leukaemia 23.04 14.15 50 117867 5722 42497696
Respiratory distress 23.04 14.15 196 117721 41624 42461794
Vocal cord paralysis 23.02 14.15 22 117895 1172 42502246
Aplastic anaemia 22.97 14.15 81 117836 12303 42491115
Osteosarcoma 22.89 14.15 13 117904 305 42503113
Laboratory test abnormal 22.87 14.15 18 117899 22960 42480458
Pseudomonas test positive 22.77 14.15 24 117893 1439 42501979
Chronic lymphocytic leukaemia refractory 22.70 14.15 9 117908 90 42503328
Epstein-Barr virus infection reactivation 22.70 14.15 32 117885 2595 42500823
Cardiomegaly 22.63 14.15 9 117908 16757 42486661
Nasal congestion 22.62 14.15 29 117888 29472 42473946
Norovirus infection 22.61 14.15 18 117899 749 42502669
Eosinophilia 22.58 14.15 35 117882 32864 42470554
Sinusitis fungal 22.53 14.15 18 117899 753 42502665
Diverticulitis 22.46 14.15 18 117899 22755 42480663
Oesophageal stenosis 22.43 14.15 28 117889 2018 42501400
Subclavian vein thrombosis 22.40 14.15 20 117897 976 42502442
Chromosomal mutation 22.32 14.15 7 117910 32 42503386
Hepatic infection fungal 22.24 14.15 12 117905 254 42503164
Gout 22.12 14.15 27 117890 28028 42475390
Cerebral salt-wasting syndrome 22.08 14.15 8 117909 61 42503357
Rhinovirus infection 22.02 14.15 53 117864 6495 42496923
Pulmonary sarcoidosis 21.94 14.15 18 117899 782 42502636
Positron emission tomogram abnormal 21.93 14.15 11 117906 199 42503219
Streptococcal bacteraemia 21.83 14.15 32 117885 2690 42500728
Drug eruption 21.82 14.15 19 117898 23056 42480362
Basal cell naevus syndrome 21.81 14.15 7 117910 35 42503383
Metastases to meninges 21.76 14.15 27 117890 1934 42501484
Lung neoplasm malignant 21.72 14.15 13 117904 19134 42484284
Ventricular fibrillation 21.69 14.15 31 117886 30092 42473326
Skin cancer 21.64 14.15 3 117914 11459 42491959
Cellulitis gangrenous 21.62 14.15 12 117905 269 42503149
Adenocarcinoma gastric 21.60 14.15 23 117894 1395 42502023
Platelet transfusion 21.54 14.15 25 117892 1669 42501749
Joint stiffness 21.52 14.15 4 117913 12318 42491100
Parasitic gastroenteritis 21.44 14.15 10 117907 153 42503265
Cold sweat 21.31 14.15 3 117914 11327 42492091
Eye irritation 21.28 14.15 3 117914 11315 42492103
Candida sepsis 21.24 14.15 23 117894 1422 42501996
Irritability 21.21 14.15 28 117889 28100 42475318
Pneumatosis intestinalis 21.11 14.15 43 117874 4709 42498709
Catheter site thrombosis 21.10 14.15 10 117907 159 42503259
Urinary tract obstruction 20.98 14.15 39 117878 3992 42499426
Philadelphia chromosome positive 20.97 14.15 16 117901 625 42502793
Secondary immunodeficiency 20.88 14.15 18 117899 838 42502580
Ocular hyperaemia 20.85 14.15 9 117908 15954 42487464
Personality change due to a general medical condition 20.75 14.15 7 117910 42 42503376
Body temperature decreased 20.70 14.15 7 117910 14406 42489012
Pneumoperitoneum 20.60 14.15 29 117888 2349 42501069
Panic attack 20.60 14.15 3 117914 11042 42492376
Abdominal mass 20.53 14.15 29 117888 2357 42501061
Rash maculo-papular 20.35 14.15 46 117871 37457 42465961
Phlebitis infective 20.34 14.15 9 117908 121 42503297
Sphingomonas paucimobilis infection 20.34 14.15 7 117910 45 42503373
Myocardial ischaemia 20.23 14.15 12 117905 17750 42485668
Chloroma 20.20 14.15 15 117902 562 42502856
Candida pneumonia 20.13 14.15 17 117900 769 42502649
Alanine aminotransferase increased 20.06 14.15 350 117567 88056 42415362
Flatulence 20.05 14.15 24 117893 25128 42478290
Therapy responder 19.98 14.15 10 117907 180 42503238
Helicobacter sepsis 19.97 14.15 6 117911 23 42503395
Gastrointestinal mucosal disorder 19.92 14.15 14 117903 481 42502937
Cardiac disorder 19.89 14.15 69 117848 48863 42454555
Hypoaesthesia 19.89 14.15 116 117801 71347 42432071
Ventricular tachycardia 19.84 14.15 33 117884 30127 42473291
Disseminated intravascular coagulation 19.84 14.15 127 117790 24667 42478751
Dysphonia 19.78 14.15 30 117887 28420 42474998
B-cell type acute leukaemia 19.73 14.15 17 117900 791 42502627
Sopor 19.69 14.15 6 117911 13196 42490222
Abdominal lymphadenopathy 19.60 14.15 19 117898 1030 42502388
Retinopathy proliferative 19.59 14.15 8 117909 87 42503331
Incorrect route of product administration 19.58 14.15 23 117894 24282 42479136
Herpes virus infection 19.57 14.15 36 117881 3656 42499762
Pseudomonal sepsis 19.53 14.15 39 117878 4210 42499208
Taeniasis 19.47 14.15 7 117910 52 42503366
Lip scab 19.43 14.15 8 117909 89 42503329
Microgenia 19.34 14.15 5 117912 9 42503409
Abnormal behaviour 19.27 14.15 27 117890 26424 42476994
Metastases to retroperitoneum 19.26 14.15 11 117906 261 42503157
Swelling face 19.21 14.15 29 117888 27525 42475893
Premature ageing 19.19 14.15 8 117909 92 42503326
Candida endophthalmitis 19.16 14.15 9 117908 140 42503278
Pulmonary oedema 19.14 14.15 79 117838 53193 42450225
T-cell prolymphocytic leukaemia 19.13 14.15 7 117910 55 42503363
Antithrombin III deficiency 19.11 14.15 9 117908 141 42503277
Speech disorder 19.03 14.15 32 117885 29089 42474329
Acute promyelocytic leukaemia 19.02 14.15 16 117901 720 42502698
Vagus nerve paralysis 19.00 14.15 5 117912 10 42503408
Splenic lesion 18.99 14.15 12 117905 344 42503074
Acne 18.96 14.15 7 117910 13637 42489781
Urinary bladder rupture 18.89 14.15 8 117909 96 42503322
Bacterial infection 18.85 14.15 137 117780 27742 42475676
Hyperlipidaemia 18.84 14.15 19 117898 21497 42481921
Transplant rejection 18.83 14.15 7 117910 13581 42489837
Gastroenteritis adenovirus 18.82 14.15 10 117907 205 42503213
Enterovirus test positive 18.82 14.15 8 117909 97 42503321
Infantile vomiting 18.74 14.15 8 117909 98 42503320
Eye pain 18.71 14.15 12 117905 17018 42486400
Splenic marginal zone lymphoma 18.69 14.15 6 117911 30 42503388
Toxocariasis 18.69 14.15 6 117911 30 42503388
Depressed level of consciousness 18.60 14.15 69 117848 47901 42455517
Respiratory moniliasis 18.53 14.15 11 117906 281 42503137
Endocarditis bacterial 18.52 14.15 20 117897 1233 42502185
Non-alcoholic steatohepatitis 18.49 14.15 18 117899 981 42502437
Fungaemia 18.44 14.15 32 117885 3104 42500314
Urethral obstruction 18.39 14.15 10 117907 215 42503203
Chronic lymphocytic leukaemia transformation 18.35 14.15 10 117907 216 42503202
Coronary artery occlusion 18.31 14.15 4 117913 10993 42492425
Hepatic amoebiasis 18.31 14.15 7 117910 63 42503355
Combined immunodeficiency 18.25 14.15 8 117909 105 42503313
Urinary retention 18.21 14.15 58 117859 42156 42461262
Salivary hypersecretion 18.18 14.15 4 117913 10939 42492479
Pulmonary toxicity 18.16 14.15 59 117858 8596 42494822
Blood urine present 18.11 14.15 5 117912 11728 42491690
Meningitis tuberculous 18.04 14.15 15 117902 664 42502754
Stem cell transplant 18.03 14.15 29 117888 2643 42500775
Clostridium bacteraemia 18.02 14.15 10 117907 224 42503194
Gastrointestinal haemorrhage 18.00 14.15 178 117739 97548 42405870
Gait inability 17.97 14.15 22 117895 22811 42480607
Focal nodular hyperplasia 17.94 14.15 9 117908 163 42503255
Bile duct necrosis 17.93 14.15 7 117910 67 42503351
Parasitic pneumonia 17.92 14.15 6 117911 35 42503383
Eye disorder 17.83 14.15 5 117912 11607 42491811
Acute lung injury 17.82 14.15 22 117895 1567 42501851
Klebsiella bacteraemia 17.82 14.15 27 117890 2337 42501081
Optic glioma 17.78 14.15 6 117911 36 42503382
Graft versus host disease in gastrointestinal tract 17.69 14.15 42 117875 5101 42498317
Cytomegalovirus colitis 17.65 14.15 36 117881 3945 42499473
Infection in an immunocompromised host 17.64 14.15 18 117899 1039 42502379
Enterocolitis 17.61 14.15 64 117853 9865 42493553
Dyskinesia 17.44 14.15 27 117890 25363 42478055
Suspected product quality issue 17.41 14.15 10 117907 240 42503178
Leukaemia cutis 17.40 14.15 7 117910 73 42503345
Metastases to muscle 17.37 14.15 10 117907 241 42503177
Flagellate dermatitis 17.36 14.15 8 117909 119 42503299
Disease susceptibility 17.32 14.15 7 117910 74 42503344
Renal salt-wasting syndrome 17.28 14.15 12 117905 404 42503014
Blastic plasmacytoid dendritic cell neoplasia 17.23 14.15 7 117910 75 42503343
Ileus 17.18 14.15 101 117816 19038 42484380
Toxic leukoencephalopathy 17.15 14.15 15 117902 712 42502706
Impaired work ability 17.14 14.15 6 117911 12085 42491333
Rash macular 17.10 14.15 13 117904 16878 42486540
Pneumothorax spontaneous 17.10 14.15 16 117901 830 42502588
Morphoea 17.08 14.15 10 117907 249 42503169
Muscle rigidity 17.07 14.15 6 117911 12053 42491365
Atrioventricular block 17.06 14.15 3 117914 9612 42493806
Restless legs syndrome 17.05 14.15 3 117914 9611 42493807
Biliary abscess 17.00 14.15 6 117911 42 42503376
Natural killer-cell lymphoblastic lymphoma 17.00 14.15 6 117911 42 42503376
Sinus bradycardia 16.96 14.15 10 117907 14843 42488575
Tooth disorder 16.89 14.15 6 117911 11973 42491445
Coronary artery stenosis 16.83 14.15 4 117913 10375 42493043
Enterococcus test positive 16.80 14.15 22 117895 1663 42501755
Gastrointestinal protozoal infection 16.76 14.15 7 117910 81 42503337
Blood potassium decreased 16.73 14.15 19 117898 20365 42483053
Periorbital infection 16.70 14.15 9 117908 190 42503228
Refractory anaemia with an excess of blasts 16.64 14.15 11 117906 341 42503077
5q minus syndrome 16.61 14.15 8 117909 132 42503286
Corynebacterium infection 16.51 14.15 16 117901 867 42502551
Cancer fatigue 16.45 14.15 9 117908 196 42503222
Splenic candidiasis 16.38 14.15 7 117910 86 42503332
Vasculitis 16.38 14.15 16 117901 18378 42485040
Cystitis noninfective 16.33 14.15 13 117904 541 42502877
Product administration error 16.29 14.15 16 117901 18327 42485091
Angioimmunoblastic T-cell lymphoma recurrent 16.28 14.15 5 117912 21 42503397
Gastrointestinal obstruction 16.25 14.15 18 117899 1142 42502276
Pseudomonas aeruginosa meningitis 16.20 14.15 6 117911 49 42503369
Disseminated cytomegaloviral infection 16.19 14.15 10 117907 275 42503143
Escherichia test positive 15.98 14.15 19 117898 1302 42502116
Anisocytosis 15.94 14.15 13 117904 560 42502858
Blood pressure abnormal 15.93 14.15 4 117913 9994 42493424
Intracranial pressure increased 15.90 14.15 38 117879 4636 42498782
Traumatic lung injury 15.85 14.15 19 117898 1313 42502105
Hydronephrosis 15.84 14.15 70 117847 11795 42491623
Urinary tract infection 15.81 14.15 187 117730 99097 42404321
Peripheral blood stem cell apheresis 15.79 14.15 8 117909 148 42503270
Picornavirus infection 15.79 14.15 6 117911 53 42503365
Glycosylated haemoglobin increased 15.78 14.15 8 117909 12916 42490502
Ventricular dysfunction 15.74 14.15 37 117880 4466 42498952
Peritoneal lesion 15.69 14.15 8 117909 150 42503268
Tendonitis 15.68 14.15 4 117913 9890 42493528
Bronchiectasis 15.67 14.15 16 117901 18003 42485415
Respiratory tract infection fungal 15.62 14.15 15 117902 804 42502614
Rales 15.59 14.15 6 117911 11394 42492024
Pneumonia adenoviral 15.54 14.15 11 117906 382 42503036
Ear infection 15.52 14.15 8 117909 12796 42490622
Retinitis viral 15.46 14.15 8 117909 155 42503263
Disseminated blastomycosis 15.42 14.15 11 117906 387 42503031
Cognitive disorder 15.41 14.15 46 117871 34126 42469292
Pollakiuria 15.39 14.15 24 117893 22481 42480937
Acute myocardial infarction 15.35 14.15 96 117821 58069 42445349
Cerebellar syndrome 15.34 14.15 28 117889 2827 42500591
Pneumonia necrotising 15.26 14.15 17 117900 1085 42502333
Diffuse alopecia 15.25 14.15 7 117910 103 42503315
Ganglioneuroma 15.20 14.15 4 117913 8 42503410
Proteus infection 15.20 14.15 19 117898 1371 42502047
Facial paresis 15.14 14.15 30 117887 3220 42500198
Plasma cells decreased 15.14 14.15 6 117911 60 42503358
Gastric disorder 15.14 14.15 7 117910 11915 42491503
Inferior vena caval occlusion 15.14 14.15 6 117911 60 42503358
Lymph node haemorrhage 15.11 14.15 5 117912 28 42503390
Appendiceal abscess 15.07 14.15 7 117910 106 42503312
Herpes simplex test positive 15.02 14.15 9 117908 234 42503184
Mydriasis 14.99 14.15 3 117914 8767 42494651
Blood pressure diastolic decreased 14.97 14.15 5 117912 10370 42493048
Congenital herpes simplex infection 14.96 14.15 5 117912 29 42503389
Congenital hepatobiliary anomaly 14.96 14.15 5 117912 29 42503389
Neuroborreliosis 14.88 14.15 6 117911 63 42503355
Chromosomal deletion 14.88 14.15 6 117911 63 42503355
Leukaemic infiltration 14.84 14.15 8 117909 169 42503249
B precursor type acute leukaemia 14.79 14.15 9 117908 241 42503177
Acute hepatitis B 14.79 14.15 9 117908 241 42503177
Kidney transplant rejection 14.78 14.15 3 117914 8680 42494738
Lacrimation increased 14.78 14.15 7 117910 11751 42491667
Multiple lentigines syndrome 14.68 14.15 5 117912 31 42503387
Psychomotor hyperactivity 14.60 14.15 6 117911 10952 42492466
Renal disorder 14.57 14.15 37 117880 28943 42474475
Electrolyte imbalance 14.56 14.15 89 117828 17012 42486406
Constipation 14.50 14.15 340 117577 161951 42341467
Neurological examination abnormal 14.47 14.15 10 117907 334 42503084
Exposure during pregnancy 14.46 14.15 3 117914 8545 42494873
Carnitine deficiency 14.45 14.15 7 117910 117 42503301
Electrocardiogram abnormal 14.44 14.15 5 117912 10140 42493278
Haematuria 14.44 14.15 97 117820 57702 42445716
Cytogenetic analysis abnormal 14.41 14.15 14 117903 761 42502657
Jejunal stenosis 14.39 14.15 6 117911 69 42503349
Prescribed overdose 14.35 14.15 9 117908 12918 42490500
Skin candida 14.33 14.15 13 117904 648 42502770
Retroperitoneal mass 14.30 14.15 7 117910 120 42503298
Germ cell cancer 14.30 14.15 7 117910 120 42503298
Acral lentiginous melanoma 14.29 14.15 5 117912 34 42503384
Underdose 14.27 14.15 15 117902 16651 42486767
Diffuse large B-cell lymphoma stage IV 14.25 14.15 12 117905 541 42502877
BK virus infection 14.23 14.15 55 117862 8729 42494689
Mastitis 14.23 14.15 8 117909 184 42503234
C-reactive protein abnormal 14.20 14.15 4 117913 9257 42494161

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 12420.09 14.48 7323 181565 309444 110090967
Neutropenia 3793.75 14.48 3887 185001 370733 110029678
Disease progression 3570.37 14.48 3107 185781 240927 110159484
Myelosuppression 1828.97 14.48 1417 187471 92923 110307488
Pancytopenia 1669.12 14.48 1920 186968 207693 110192718
Mucosal inflammation 1628.29 14.48 1334 187554 94807 110305604
Diffuse large B-cell lymphoma recurrent 1574.31 14.48 537 188351 5762 110394649
Haematotoxicity 1555.49 14.48 747 188141 20335 110380076
Second primary malignancy 1335.36 14.48 641 188247 17427 110382984
Thrombocytopenia 1227.93 14.48 2163 186725 346722 110053689
Off label use 1201.29 14.48 5389 183499 1494796 108905615
Tumour lysis syndrome 1186.24 14.48 708 188180 30093 110370318
Bone marrow failure 1162.35 14.48 888 188000 56960 110343451
Febrile bone marrow aplasia 1130.37 14.48 566 188322 16899 110383512
Myelodysplastic syndrome 1075.47 14.48 715 188173 36769 110363642
Acute myeloid leukaemia 1067.09 14.48 716 188172 37394 110363017
Hepatitis B reactivation 1035.53 14.48 413 188475 7071 110393340
Septic shock 1018.04 14.48 1299 187589 156229 110244182
Posterior reversible encephalopathy syndrome 1017.87 14.48 665 188223 33196 110367215
Sepsis 993.02 14.48 1904 186984 325442 110074969
Neoplasm progression 970.79 14.48 837 188051 63758 110336653
Product use in unapproved indication 937.96 14.48 2239 186649 445138 109955273
Neuropathy peripheral 888.44 14.48 1300 187588 177977 110222434
Cytokine release syndrome 819.51 14.48 790 188098 69516 110330895
Venoocclusive liver disease 778.10 14.48 421 188467 14786 110385625
Therapy partial responder 726.96 14.48 561 188327 36500 110363911
Hepatitis B 719.25 14.48 344 188544 9268 110391143
Pain 714.93 14.48 371 188517 954584 109445827
Leukopenia 705.41 14.48 1057 187831 147734 110252677
Cytopenia 693.64 14.48 502 188386 29614 110370797
Disease recurrence 672.79 14.48 664 188224 60120 110340291
Joint swelling 661.56 14.48 21 188867 442824 109957587
Arthralgia 640.21 14.48 266 188622 779366 109621045
Malignant neoplasm progression 595.68 14.48 1069 187819 173498 110226913
Neurotoxicity 590.01 14.48 525 188363 41682 110358729
Fall 563.62 14.48 166 188722 603316 109797095
Neutropenic sepsis 563.16 14.48 447 188441 30299 110370112
Pyrexia 561.24 14.48 3014 185874 895251 109505160
Acute lymphocytic leukaemia recurrent 500.71 14.48 229 188659 5558 110394853
Fatigue 499.99 14.48 819 188069 1215139 109185272
Pruritus 499.12 14.48 185 188703 581375 109819036
Cardiotoxicity 488.89 14.48 324 188564 16557 110383854
Nasopharyngitis 484.32 14.48 54 188834 394307 110006104
Rheumatoid arthritis 484.28 14.48 5 188883 299608 110100803
Peripheral swelling 477.34 14.48 63 188825 403971 109996440
Pneumocystis jirovecii pneumonia 473.15 14.48 467 188421 42268 110358143
Aspergillus infection 466.11 14.48 371 188517 25245 110375166
Hypertriglyceridaemia 465.30 14.48 309 188579 15845 110384566
Multiple organ dysfunction syndrome 464.66 14.48 887 188001 150823 110249588
Product dose omission issue 457.55 14.48 22 188866 321760 110078651
Rash 455.87 14.48 439 188449 820525 109579886
Cytomegalovirus chorioretinitis 455.27 14.48 229 188659 6899 110393512
Abdominal discomfort 452.14 14.48 67 188821 393791 110006620
Arthropathy 450.77 14.48 8 188880 287514 110112897
Synovitis 445.67 14.48 4 188884 274088 110126323
Neutrophil count decreased 445.28 14.48 766 188122 120175 110280236
Dizziness 434.13 14.48 335 188553 697858 109702553
Progressive multifocal leukoencephalopathy 431.91 14.48 351 188537 24605 110375806
Malaise 420.66 14.48 320 188568 671499 109728912
Hypofibrinogenaemia 412.83 14.48 157 188731 2350 110398061
Weight increased 411.07 14.48 105 188783 419539 109980872
Diffuse large B-cell lymphoma refractory 401.22 14.48 154 188734 2367 110398044
Hypogammaglobulinaemia 400.43 14.48 307 188581 19769 110380642
Swelling 397.67 14.48 62 188826 350979 110049432
Drug hypersensitivity 396.99 14.48 140 188748 453950 109946461
Blood lactate dehydrogenase increased 391.10 14.48 429 188459 43905 110356506
Insomnia 390.14 14.48 72 188816 360518 110039893
Bacteraemia 389.33 14.48 419 188469 41971 110358440
Musculoskeletal stiffness 385.71 14.48 23 188865 279799 110120612
Haemophagocytic lymphohistiocytosis 366.41 14.48 354 188534 31205 110369206
Dyspnoea 360.75 14.48 854 188034 1106018 109294393
Anaemia 354.36 14.48 1856 187032 545230 109855181
Neutropenic colitis 351.64 14.48 201 188687 7864 110392547
Bronchopulmonary aspergillosis 348.64 14.48 336 188552 29527 110370884
B-cell lymphoma recurrent 346.14 14.48 113 188775 1045 110399366
Secondary immunodeficiency 345.73 14.48 166 188722 4510 110395901
Wound 343.26 14.48 13 188875 234424 110165987
Diffuse large B-cell lymphoma 334.49 14.48 251 188637 15647 110384764
Headache 333.18 14.48 626 188262 881751 109518660
Asthma 331.95 14.48 25 188863 250266 110150145
Glossodynia 326.11 14.48 12 188876 221992 110178419
Lymphadenopathy 313.01 14.48 461 188427 63374 110337037
Psoriatic arthropathy 310.32 14.48 5 188883 196756 110203655
Epstein-Barr virus infection 306.36 14.48 255 188633 18483 110381928
Anxiety 305.61 14.48 104 188784 344974 110055437
Neoplasm recurrence 304.85 14.48 158 188730 5074 110395337
Interstitial lung disease 302.46 14.48 708 188180 138626 110261785
Polyneuropathy 302.04 14.48 321 188567 31691 110368720
Ototoxicity 294.39 14.48 143 188745 3988 110396423
Respiratory failure 291.19 14.48 919 187969 214413 110185998
Platelet count decreased 289.49 14.48 959 187929 229484 110170927
Hyperbilirubinaemia 286.63 14.48 306 188582 30365 110370046
Contusion 286.23 14.48 32 188856 233329 110167082
Leukoencephalopathy 279.68 14.48 182 188706 9013 110391398
Wheezing 278.06 14.48 50 188838 255180 110145231
Venoocclusive disease 273.48 14.48 157 188731 6193 110394218
Muscle spasms 273.40 14.48 69 188819 278088 110122323
Drug resistance 273.34 14.48 405 188483 55969 110344442
Myelopathy 273.10 14.48 150 188738 5426 110394985
Candida infection 272.75 14.48 372 188516 47637 110352774
Discomfort 269.59 14.48 27 188861 214680 110185731
Post transplant lymphoproliferative disorder 268.90 14.48 219 188669 15394 110385017
Duodenal ulcer perforation 266.66 14.48 8 188880 177692 110222719
Mobility decreased 264.14 14.48 44 188844 237378 110163033
Folliculitis 261.32 14.48 5 188883 167648 110232763
COVID-19 261.26 14.48 966 187922 244094 110156317
Irritable bowel syndrome 259.68 14.48 4 188884 164211 110236200
Urticaria 259.16 14.48 110 188778 318747 110081664
Pain in extremity 258.98 14.48 270 188618 486848 109913563
Inappropriate schedule of product administration 257.27 14.48 25 188863 203612 110196799
Injury 255.53 14.48 11 188877 177254 110223157
White blood cell count decreased 255.31 14.48 917 187971 228473 110171938
Aplasia 254.70 14.48 162 188726 7711 110392700
Osteoarthritis 251.64 14.48 15 188873 182608 110217803
Cardiomyopathy 250.96 14.48 298 188590 33227 110367184
Blood cholesterol increased 249.19 14.48 17 188871 184768 110215643
Blister 248.86 14.48 44 188844 227332 110173079
Clostridium difficile colitis 248.37 14.48 339 188549 43439 110356972
Drug abuse 246.20 14.48 14 188874 177397 110223014
Sleep disorder 244.21 14.48 27 188861 198617 110201794
Injection site pain 243.99 14.48 15 188873 177907 110222504
Contraindicated product administered 239.37 14.48 64 188824 248203 110152208
Lymphopenia 238.46 14.48 318 188570 39852 110360559
Systemic candida 235.88 14.48 169 188719 9805 110390606
Cytomegalovirus infection 235.55 14.48 371 188517 54073 110346338
Acquired gene mutation 232.05 14.48 107 188781 2647 110397764
Hypersensitivity 232.02 14.48 209 188679 403789 109996622
Drug ineffective 231.27 14.48 3758 185130 1516782 108883629
Helicobacter infection 230.62 14.48 22 188866 181855 110218556
Blood pressure increased 230.22 14.48 77 188811 258296 110142115
Lymphoma 229.89 14.48 224 188664 19947 110380464
Impaired healing 229.00 14.48 32 188856 196685 110203726
Abdominal pain upper 226.30 14.48 160 188728 348951 110051460
Pneumatosis intestinalis 226.14 14.48 155 188733 8374 110392037
Mantle cell lymphoma recurrent 223.64 14.48 79 188809 947 110399464
Bacterial infection 223.57 14.48 331 188557 45705 110354706
Agranulocytosis 213.97 14.48 381 188507 61379 110339032
Ileus paralytic 213.52 14.48 170 188718 11567 110388844
Dry mouth 211.73 14.48 42 188846 199906 110200505
Confusional state 200.89 14.48 306 188582 468374 109932037
Feeling abnormal 199.86 14.48 34 188854 180677 110219734
Depression 199.72 14.48 150 188738 317185 110083226
Sinusitis 198.90 14.48 131 188757 296557 110103854
Immune effector cell-associated neurotoxicity syndrome 198.87 14.48 180 188708 14602 110385809
Psoriasis 197.51 14.48 10 188878 139983 110260428
Acute lymphocytic leukaemia 194.94 14.48 122 188766 5643 110394768
Loss of personal independence in daily activities 193.27 14.48 17 188871 150003 110250408
Herpes simplex 192.78 14.48 182 188706 15582 110384829
Intentional product misuse 192.37 14.48 8 188880 132896 110267515
Hepatotoxicity 191.86 14.48 369 188519 63031 110337380
Klebsiella infection 191.16 14.48 202 188686 19807 110380604
Arthritis 188.74 14.48 30 188858 167556 110232855
Staphylococcal bacteraemia 185.85 14.48 183 188705 16505 110383906
Cytomegalovirus infection reactivation 185.75 14.48 191 188697 18142 110382269
Mucormycosis 184.97 14.48 150 188738 10478 110389933
Rhinovirus infection 183.57 14.48 156 188732 11633 110388778
C-reactive protein abnormal 177.61 14.48 11 188877 129684 110270727
Pneumonia fungal 175.97 14.48 168 188720 14586 110385825
Hepatic failure 173.43 14.48 371 188517 68368 110332043
Drug intolerance 172.64 14.48 267 188621 406245 109994166
Overdose 172.52 14.48 92 188796 233702 110166709
Musculoskeletal pain 169.32 14.48 51 188837 182972 110217439
Chest pain 168.80 14.48 238 188650 376137 110024274
Human herpesvirus 6 infection 168.36 14.48 117 188771 6464 110393947
Pericarditis 166.47 14.48 83 188805 219031 110181380
Hospitalisation 166.25 14.48 23 188865 142470 110257941
Enterococcal infection 165.74 14.48 189 188699 20177 110380234
Stress 164.74 14.48 3 188885 105345 110295066
COVID-19 pneumonia 164.68 14.48 256 188632 36887 110363524
Peripheral sensory neuropathy 164.00 14.48 171 188717 16509 110383902
Diarrhoea 163.58 14.48 1208 187680 1138297 109262114
Lower respiratory tract infection 163.39 14.48 107 188781 242999 110157412
Parainfluenzae virus infection 162.25 14.48 117 188771 6857 110393554
Alopecia 162.24 14.48 232 188656 364521 110035890
Human bocavirus infection 162.14 14.48 64 188824 1064 110399347
Escherichia bacteraemia 161.35 14.48 136 188752 10028 110390383
Road traffic accident 160.51 14.48 5 188883 107393 110293018
Memory impairment 159.86 14.48 68 188820 196876 110203535
Therapeutic product effect decreased 156.92 14.48 113 188775 244203 110156208
Hepatic enzyme increased 152.94 14.48 194 188694 320698 110079713
Gastrooesophageal reflux disease 152.84 14.48 58 188830 179918 110220493
Lip dry 148.36 14.48 5 188883 100078 110300333
Glioma 147.62 14.48 56 188832 832 110399579
Ejection fraction decreased 146.51 14.48 256 188632 40624 110359787
Lymphadenitis 146.04 14.48 100 188788 5393 110395018
Dyspepsia 145.57 14.48 72 188816 190893 110209518
Pseudomonal sepsis 141.46 14.48 120 188768 8926 110391485
Type 2 diabetes mellitus 140.98 14.48 63 188825 177169 110223242
Intestinal perforation 140.25 14.48 176 188712 20768 110379643
Enterobacter infection 138.65 14.48 99 188789 5712 110394699
Gene mutation 137.65 14.48 81 188807 3348 110397063
Lymphoma transformation 137.36 14.48 48 188840 556 110399855
Central nervous system lymphoma 135.75 14.48 77 188811 2967 110397444
Hypoaesthesia 133.73 14.48 206 188682 314017 110086394
Strongyloidiasis 133.10 14.48 91 188797 4895 110395516
Bronchitis 132.68 14.48 51 188837 156981 110243430
Cystitis bacterial 132.23 14.48 57 188831 1196 110399215
Coombs positive haemolytic anaemia 132.02 14.48 61 188827 1516 110398895
Nausea 131.51 14.48 1414 187474 1234276 109166135
Myocardial infarction 131.16 14.48 83 188805 192000 110208411
Pseudomonas infection 129.14 14.48 196 188692 27657 110372754
Dry skin 128.88 14.48 16 188872 107637 110292774
Escherichia sepsis 128.30 14.48 120 188768 10152 110390259
Hepatitis E 127.69 14.48 85 188803 4374 110396037
Oedema peripheral 127.32 14.48 229 188659 328431 110071980
Staphylococcal sepsis 127.09 14.48 153 188735 17301 110383110
Injection site reaction 126.79 14.48 6 188882 89064 110311347
Fungal infection 126.76 14.48 273 188615 50533 110349878
Encephalopathy 126.46 14.48 364 188524 80691 110319720
Blood culture positive 126.08 14.48 112 188776 8864 110391547
Obesity 126.04 14.48 21 188867 113330 110287081
Neck pain 125.94 14.48 28 188860 123102 110277309
Glioblastoma multiforme 125.88 14.48 58 188830 1432 110398979
Pseudomonal bacteraemia 124.39 14.48 83 188805 4288 110396123
Back pain 123.68 14.48 282 188606 370714 110029697
Cystitis haemorrhagic 123.33 14.48 127 188761 12082 110388329
Mycobacterium chelonae infection 122.09 14.48 72 188816 2988 110397423
Osteonecrosis 121.83 14.48 212 188676 33529 110366882
Myalgia 121.74 14.48 120 188768 222261 110178150
Malignant transformation 121.50 14.48 57 188831 1468 110398943
Left ventricular dysfunction 121.44 14.48 174 188714 23319 110377092
JC virus infection 121.36 14.48 88 188800 5202 110395209
Somnolence 120.92 14.48 201 188687 297248 110103163
Injection site erythema 120.41 14.48 11 188877 94165 110306246
Incorrect dose administered 120.26 14.48 17 188871 103624 110296787
Disseminated intravascular coagulation 119.67 14.48 236 188652 41050 110359361
Epstein-Barr virus associated lymphoma 119.57 14.48 58 188830 1612 110398799
Gait inability 119.08 14.48 42 188846 136334 110264077
Inappropriate antidiuretic hormone secretion 118.74 14.48 210 188678 33641 110366770
Norovirus test positive 118.62 14.48 49 188839 921 110399490
Pleural effusion 118.15 14.48 608 188280 177101 110223310
Blood fibrinogen decreased 117.50 14.48 67 188821 2608 110397803
Superior sagittal sinus thrombosis 116.94 14.48 51 188837 1102 110399309
Prescribed overdose 115.35 14.48 9 188879 87572 110312839
Sciatica 114.96 14.48 12 188876 92387 110308024
Peripheral motor neuropathy 114.86 14.48 77 188811 4009 110396402
Adverse event 114.86 14.48 23 188865 108786 110291625
Adenovirus infection 114.03 14.48 116 188772 10878 110389533
Escherichia infection 113.84 14.48 170 188718 23646 110376765
Epstein-Barr virus associated lymphoproliferative disorder 112.71 14.48 81 188807 4721 110395690
Rhabdomyolysis 112.35 14.48 33 188855 120368 110280043
Adverse drug reaction 112.08 14.48 22 188866 105537 110294874
Suicidal ideation 109.95 14.48 15 188873 93922 110306489
Bacterial sepsis 109.95 14.48 111 188777 10315 110390096
Wound infection 109.21 14.48 17 188871 96448 110303963
Gastrosplenic fistula 108.40 14.48 29 188859 121 110400290
Therapy non-responder 107.93 14.48 543 188345 156764 110243647
Erythema 107.64 14.48 209 188679 291238 110109173
Hyperhidrosis 106.10 14.48 98 188790 187200 110213211
Pneumonia 105.87 14.48 2092 186796 874622 109525789
Gait disturbance 105.82 14.48 196 188692 278012 110122399
Colitis 105.28 14.48 399 188489 101924 110298487
Cerebral venous thrombosis 105.21 14.48 67 188821 3195 110397216
Hypercholesterolaemia 105.16 14.48 15 188873 90822 110309589
Sedation 105.01 14.48 3 188885 69680 110330731
Cerebral venous sinus thrombosis 104.83 14.48 64 188824 2831 110397580
Cytomegalovirus viraemia 104.45 14.48 140 188748 17624 110382787
Palpitations 104.36 14.48 72 188816 159140 110241271
Gastrointestinal toxicity 103.75 14.48 111 188777 11037 110389374
Blood pressure fluctuation 103.49 14.48 6 188882 74818 110325593
Leukaemia recurrent 102.71 14.48 65 188823 3066 110397345
Enterovirus infection 102.26 14.48 62 188826 2708 110397703
Cardiac failure 101.41 14.48 607 188281 187019 110213392
Thymus hypoplasia 101.32 14.48 52 188836 1635 110398776
Frequent bowel movements 101.00 14.48 5 188883 71385 110329026
Chest discomfort 100.82 14.48 89 188799 173759 110226652
Minimal residual disease 99.42 14.48 43 188845 910 110399501
Colitis ulcerative 99.00 14.48 9 188879 77354 110323057
Infection reactivation 96.16 14.48 69 188819 4012 110396399
Clostridium difficile infection 95.15 14.48 248 188640 51881 110348530
Enterococcal bacteraemia 95.10 14.48 71 188817 4390 110396021
Product quality issue 93.73 14.48 11 188877 77288 110323123
Infusion related reaction 93.71 14.48 335 188553 380827 110019584
Viraemia 93.56 14.48 68 188820 4034 110396377
Migraine 93.51 14.48 93 188795 171559 110228852
Lymphoid tissue hypoplasia 93.34 14.48 49 188839 1616 110398795
Blood pressure systolic increased 93.10 14.48 15 188873 82976 110317435
Inflammation 92.88 14.48 116 188772 193122 110207289
Hepatomegaly 92.71 14.48 146 188742 21268 110379143
Venous thrombosis 92.36 14.48 92 188796 8413 110391998
Asthenia 92.17 14.48 744 188144 688255 109712156
Oedema 90.90 14.48 136 188752 209840 110190571
Oesophageal candidiasis 90.42 14.48 105 188783 11429 110388982
Device related infection 90.28 14.48 205 188683 39314 110361097
Suicide attempt 89.99 14.48 32 188856 103362 110297049
Illness 89.65 14.48 16 188872 82155 110318256
Amnesia 89.42 14.48 34 188854 105374 110295037
Coagulopathy 88.82 14.48 208 188680 40703 110359708
Feeling hot 88.68 14.48 23 188865 91083 110309328
Klebsiella sepsis 88.32 14.48 66 188822 4087 110396324
Joint stiffness 88.30 14.48 7 188881 67236 110333175
Ascites 87.43 14.48 352 188536 92456 110307955
Antithrombin III decreased 87.19 14.48 33 188855 487 110399924
Pleuroparenchymal fibroelastosis 87.00 14.48 30 188858 333 110400078
Hypertension 86.87 14.48 513 188375 509571 109890840
Infection 86.61 14.48 973 187915 361227 110039184
Heart rate decreased 86.29 14.48 18 188870 82738 110317673
Fungaemia 85.60 14.48 76 188812 6010 110394401
Babesiosis 85.12 14.48 32 188856 463 110399948
Ileus 84.68 14.48 172 188716 30557 110369854
Condition aggravated 84.44 14.48 825 188063 734011 109666400
Hot flush 83.65 14.48 8 188880 66028 110334383
Smooth muscle cell neoplasm 83.15 14.48 43 188845 1374 110399037
Weight decreased 82.77 14.48 465 188423 467592 109932819
Injection site swelling 82.36 14.48 6 188882 61784 110338627
Systemic mycosis 81.76 14.48 61 188827 3768 110396643
Aplastic anaemia 81.67 14.48 148 188740 24160 110376251
Eczema 81.25 14.48 13 188875 72280 110328131
Pneumocystis jirovecii infection 80.61 14.48 64 188824 4336 110396075
Sweat gland tumour 80.52 14.48 32 188856 542 110399869
Autoimmune disorder 80.20 14.48 9 188879 65474 110334937
West Nile viral infection 80.01 14.48 41 188847 1285 110399126
Hepatocellular injury 79.54 14.48 228 188660 50414 110349997
Hepatosplenomegaly 79.14 14.48 77 188811 6842 110393569
Nephropathy toxic 78.34 14.48 156 188732 27322 110373089
Vocal cord paralysis 78.21 14.48 54 188834 2952 110397459
Rash pruritic 77.75 14.48 35 188853 98034 110302377
Hallucination 77.65 14.48 38 188850 101394 110299017
Fluid retention 77.41 14.48 32 188856 94275 110306136
Prescribed underdose 77.25 14.48 10 188878 65164 110335247
Remission not achieved 76.10 14.48 30 188858 497 110399914
Cerebrovascular accident 75.98 14.48 120 188768 181164 110219247
Ear infection 75.88 14.48 9 188879 62723 110337688
Loss of consciousness 75.78 14.48 137 188751 196169 110204242
Heart rate increased 74.87 14.48 81 188807 143753 110256658
Product prescribing error 74.57 14.48 3 188885 51328 110349083
Injection site pruritus 74.45 14.48 3 188885 51255 110349156
Pneumonitis 74.28 14.48 293 188595 76238 110324173
Acute myelomonocytic leukaemia 73.87 14.48 28 188860 415 110399996
Maternal exposure during pregnancy 73.85 14.48 208 188680 254675 110145736
Lung disorder 73.75 14.48 121 188767 179926 110220485
Respiratory distress 73.69 14.48 272 188616 68602 110331809
Blood glucose increased 73.07 14.48 71 188817 132425 110267986
Congestive cardiomyopathy 73.03 14.48 105 188783 14114 110386297
Visual impairment 73.02 14.48 73 188815 134355 110266056
Hip arthroplasty 72.76 14.48 6 188882 55807 110344604
Enteritis 72.62 14.48 123 188765 19033 110381378
Pseudomonas test positive 72.58 14.48 47 188841 2307 110398104
Night sweats 72.50 14.48 73 188815 133910 110266501
Burning sensation 72.28 14.48 15 188873 69197 110331214
Angioedema 72.27 14.48 39 188849 98461 110301950
Swollen tongue 72.18 14.48 9 188879 60353 110340058
Cytogenetic abnormality 72.05 14.48 37 188851 1165 110399246
Subdural hygroma 72.04 14.48 30 188858 576 110399835
Coronary artery disease 71.91 14.48 17 188871 71673 110328738
Vasogenic cerebral oedema 71.89 14.48 46 188842 2212 110398199
Peripheral sensorimotor neuropathy 71.48 14.48 57 188831 3886 110396525
Bone marrow necrosis 71.00 14.48 27 188861 404 110400007
Angiocentric lymphoma 70.48 14.48 37 188851 1220 110399191
Red blood cell sedimentation rate increased 70.28 14.48 23 188865 78279 110322132
Fusarium infection 70.27 14.48 49 188839 2722 110397689
Jugular vein thrombosis 69.77 14.48 64 188824 5281 110395130
Deafness 69.48 14.48 146 188742 26563 110373848
Varicella zoster virus infection 69.36 14.48 69 188819 6299 110394112
Exposure during pregnancy 69.06 14.48 112 188776 167312 110233099
Pathogen resistance 69.03 14.48 115 188773 17557 110382854
Vision blurred 69.01 14.48 71 188817 128951 110271460
Gastrointestinal disorder 68.96 14.48 199 188689 241753 110158658
Follicular lymphoma 68.86 14.48 31 188857 724 110399687
Hypertransaminasaemia 68.31 14.48 137 188751 24118 110376293
Depressed mood 68.19 14.48 11 188877 60798 110339613
Meningitis cryptococcal 68.04 14.48 60 188828 4702 110395709
Staphylococcal infection 67.25 14.48 267 188621 69677 110330734
Streptococcal bacteraemia 67.06 14.48 59 188829 4610 110395801
Hypoalbuminaemia 66.96 14.48 151 188737 28823 110371588
Drug interaction 66.86 14.48 540 188348 499643 109900768
Chronic obstructive pulmonary disease 66.83 14.48 53 188835 109105 110291306
Philadelphia chromosome positive 66.68 14.48 32 188856 868 110399543
Myeloid leukaemia 66.52 14.48 32 188856 873 110399538
Influenza like illness 66.35 14.48 34 188854 88378 110312033
Bone marrow disorder 65.99 14.48 56 188832 4167 110396244
Retroperitoneal lymphadenopathy 65.86 14.48 37 188851 1399 110399012
Lung infiltration 65.68 14.48 136 188752 24492 110375919
Viral haemorrhagic cystitis 65.64 14.48 51 188837 3348 110397063
Pregnancy 65.18 14.48 6 188882 51061 110349350
Cholestasis 65.05 14.48 250 188638 64268 110336143
Enterocolitis infectious 65.04 14.48 51 188837 3393 110397018
Leukaemia 64.98 14.48 72 188816 7446 110392965
Nervous system disorder 64.25 14.48 157 188731 31564 110368847
Metastases to meninges 64.22 14.48 60 188828 5068 110395343
Haemolysis 64.09 14.48 104 188784 15535 110384876
Blood stem cell transplant failure 63.96 14.48 29 188859 689 110399722
Hyperglycaemia 63.55 14.48 301 188587 84789 110315622
Quadriplegia 63.00 14.48 54 188834 4073 110396338
Klebsiella bacteraemia 62.97 14.48 58 188830 4811 110395600
Flushing 62.69 14.48 52 188836 104684 110295727
B-cell lymphoma 62.67 14.48 69 188819 7085 110393326
Skin exfoliation 62.44 14.48 36 188852 87615 110312796
Refractory anaemia with an excess of blasts 62.41 14.48 30 188858 817 110399594
Paraesthesia 62.13 14.48 252 188636 276269 110124142
Intussusception 61.70 14.48 37 188851 1584 110398827
Enterovirus test positive 61.68 14.48 23 188865 325 110400086
Stomatitis 61.42 14.48 719 188169 269523 110130888
Balance disorder 61.38 14.48 65 188823 116495 110283916
Live birth 61.34 14.48 21 188867 69463 110330948
Acute promyelocytic leukaemia 61.29 14.48 39 188849 1857 110398554
Encephalitis 61.14 14.48 113 188775 18726 110381685
Nasal congestion 61.07 14.48 47 188841 98235 110302176
Medication error 61.00 14.48 54 188834 105312 110295099
Acute hepatitis B 60.51 14.48 26 188862 541 110399870
Drug ineffective for unapproved indication 60.28 14.48 340 188548 102498 110297913
Haematopoietic stem cell mobilisation 60.26 14.48 24 188864 409 110400002
Platelet transfusion 60.01 14.48 45 188843 2801 110397610
Blood creatine phosphokinase increased 59.64 14.48 25 188863 73052 110327359
Hyperpyrexia 59.18 14.48 71 188817 7998 110392413
Cardiomyopathy acute 58.23 14.48 23 188865 383 110400028
Peripheral T-cell lymphoma unspecified 58.00 14.48 29 188859 862 110399549
5q minus syndrome 57.90 14.48 21 188867 273 110400138
Lymphocytosis 57.78 14.48 58 188830 5353 110395058
Geotrichum infection 57.69 14.48 32 188856 1180 110399231
BK virus infection 57.62 14.48 90 188798 13016 110387395
Epstein-Barr viraemia 57.04 14.48 48 188840 3531 110396880
Acute lymphocytic leukaemia refractory 56.96 14.48 19 188869 189 110400222
Gastritis bacterial 56.87 14.48 25 188863 551 110399860
Soft tissue infection 56.86 14.48 56 188832 5051 110395360
Cerebral aspergillosis 56.73 14.48 40 188848 2262 110398149
Humoral immune defect 56.48 14.48 27 188861 726 110399685
Pneumonia klebsiella 56.44 14.48 63 188825 6569 110393842
Treatment noncompliance 56.39 14.48 27 188861 72963 110327448
Pulmonary haemorrhage 56.31 14.48 101 188787 16355 110384056
Joint injury 55.95 14.48 3 188885 39991 110360420
Vaccination failure 55.93 14.48 41 188847 2465 110397946
Tremor 55.69 14.48 169 188719 202063 110198348
Taste disorder 55.61 14.48 21 188867 65366 110335045
Serotonin syndrome 55.57 14.48 16 188872 59137 110341274
Acute respiratory distress syndrome 55.16 14.48 208 188680 52990 110347421
Drug clearance decreased 55.06 14.48 50 188838 4072 110396339
Pancreatitis acute 54.69 14.48 226 188662 60048 110340363
Bone pain 54.29 14.48 238 188650 64895 110335516
Combined immunodeficiency 54.15 14.48 18 188870 177 110400234
Nightmare 54.10 14.48 3 188885 38860 110361551
Therapy interrupted 53.70 14.48 10 188878 49812 110350599
Hepatosplenic candidiasis 53.39 14.48 25 188863 641 110399770
Rhabdomyosarcoma recurrent 53.28 14.48 17 188871 145 110400266
Pyomyositis 53.23 14.48 26 188862 734 110399677
Chronic myelomonocytic leukaemia 53.17 14.48 29 188859 1034 110399377
Pulmonary vascular disorder 52.97 14.48 29 188859 1042 110399369
Therapy responder 52.47 14.48 22 188866 430 110399981
Pneumonia cytomegaloviral 52.34 14.48 62 188826 6892 110393519
Stomatococcal infection 52.24 14.48 21 188867 367 110400044
Limb injury 52.10 14.48 3 188885 37633 110362778
Stem cell transplant 52.02 14.48 50 188838 4377 110396034
Bradycardia 51.94 14.48 118 188770 155399 110245012
Cutaneous calcification 51.78 14.48 18 188870 205 110400206
Ventricular dysfunction 51.70 14.48 64 188824 7447 110392964
Limb discomfort 51.61 14.48 5 188883 40849 110359562
Human polyomavirus infection 50.75 14.48 34 188854 1768 110398643
Autoimmune lymphoproliferative syndrome 50.71 14.48 18 188870 219 110400192
Perineal necrosis 50.71 14.48 17 188871 172 110400239
Atypical haemolytic uraemic syndrome 50.59 14.48 32 188856 1508 110398903
Splenomegaly 50.41 14.48 122 188766 24376 110376035
Leukaemia cutis 50.13 14.48 18 188870 227 110400184
Cytomegalovirus colitis 49.95 14.48 61 188827 7000 110393411
Rectal haemorrhage 49.57 14.48 80 188808 119753 110280658
Cystitis viral 49.37 14.48 31 188857 1442 110398969
Bacillus infection 49.21 14.48 32 188856 1582 110398829
Graft versus host disease 49.15 14.48 103 188785 18703 110381708
Mucosal toxicity 48.99 14.48 24 188864 682 110399729
Adenoviral hepatitis 48.94 14.48 27 188861 985 110399426
Bacillus bacteraemia 48.75 14.48 18 188870 247 110400164
Recurrent cancer 48.65 14.48 43 188845 3380 110397031
Human rhinovirus test positive 48.64 14.48 29 188859 1228 110399183
Enterocolitis 48.62 14.48 103 188785 18846 110381565
Vertigo 48.53 14.48 46 188842 86824 110313587
Underdose 48.35 14.48 24 188864 63530 110336881
Device related thrombosis 48.23 14.48 43 188845 3419 110396992
Pancreatitis 48.22 14.48 299 188589 93234 110307177
Abscess bacterial 48.09 14.48 26 188862 911 110399500
B-cell lymphoma refractory 47.89 14.48 16 188872 160 110400251
Head injury 47.75 14.48 8 188880 43009 110357402
T-cell type acute leukaemia 47.32 14.48 19 188869 331 110400080
Dry eye 47.31 14.48 18 188870 55775 110344636
Subclavian vein thrombosis 47.24 14.48 39 188849 2793 110397618
B precursor type acute leukaemia 47.06 14.48 21 188867 480 110399931
B-cell type acute leukaemia 47.04 14.48 30 188858 1434 110398977
Paraparesis 47.03 14.48 48 188840 4518 110395893
Swelling face 46.93 14.48 53 188835 92268 110308143
Pneumonia viral 46.82 14.48 75 188813 11082 110389329
Central nervous system leukaemia 46.81 14.48 22 188866 569 110399842
Wrong technique in product usage process 46.79 14.48 48 188840 87300 110313111
Neuroleptic malignant syndrome 46.29 14.48 3 188885 34056 110366355
Acute monocytic leukaemia 46.01 14.48 22 188866 592 110399819
Abdominal neoplasm 45.86 14.48 23 188865 688 110399723
Neoplasm 45.80 14.48 74 188814 11013 110389398
Osteoporosis 45.44 14.48 49 188839 87103 110313308
Acute hepatic failure 45.02 14.48 151 188737 36317 110364094
Hypoglycaemia 44.82 14.48 81 188807 116023 110284388
Iris atrophy 44.76 14.48 16 188872 199 110400212
Neurological decompensation 44.75 14.48 57 188831 6826 110393585
Cryptococcosis 44.67 14.48 47 188841 4584 110395827
Injection site haemorrhage 44.62 14.48 3 188885 33025 110367386
Electrolyte imbalance 44.55 14.48 152 188736 36876 110363535
Blood bilirubin increased 44.40 14.48 251 188637 75721 110324690
Hepatitis viral 44.38 14.48 29 188859 1446 110398965
End stage renal disease 44.25 14.48 107 188781 21366 110379045
Myelitis transverse 44.15 14.48 35 188853 2366 110398045
Coronavirus infection 44.00 14.48 67 188821 9478 110390933
Alanine aminotransferase increased 44.00 14.48 494 188394 183279 110217132
Fanconi syndrome 43.74 14.48 41 188847 3478 110396933
Lentigo 43.63 14.48 23 188865 765 110399646
Osteosarcoma 43.59 14.48 19 188869 410 110400001
Salivary gland cancer 43.47 14.48 20 188868 492 110399919
Granulocyte count decreased 43.17 14.48 43 188845 3931 110396480
Histiocytic sarcoma 42.99 14.48 13 188875 91 110400320
Sneezing 42.93 14.48 3 188885 31981 110368430
Hyperammonaemia 42.85 14.48 81 188807 13651 110386760
Cardiac dysfunction 42.79 14.48 53 188835 6170 110394241
Accidental exposure to product 42.63 14.48 16 188872 49992 110350419
Acne 42.62 14.48 4 188884 33516 110366895
Hereditary motor and sensory neuropathy 42.55 14.48 14 188874 133 110400278
Brain abscess 42.32 14.48 55 188833 6719 110393692
Stenotrophomonas infection 42.07 14.48 51 188837 5807 110394604
Withdrawal syndrome 41.96 14.48 3 188885 31377 110369034
Urinary tract infection 41.86 14.48 356 188532 325926 110074485
International normalised ratio increased 41.77 14.48 52 188836 86720 110313691
Enterobacter bacteraemia 41.69 14.48 28 188860 1462 110398949
Haematochezia 41.62 14.48 84 188804 115440 110284971
Tumour necrosis 41.59 14.48 34 188854 2402 110398009
Dysgeusia 41.57 14.48 35 188853 69950 110330461
Heart rate irregular 41.25 14.48 5 188883 34269 110366142
Delayed puberty 41.22 14.48 15 188873 197 110400214
Transformation to acute myeloid leukaemia 41.14 14.48 28 188860 1495 110398916
Joint dislocation 41.12 14.48 5 188883 34185 110366226
Cardiac failure congestive 40.99 14.48 127 188761 150873 110249538
Dysplasia 40.71 14.48 30 188858 1818 110398593
Transient ischaemic attack 40.52 14.48 30 188858 63952 110336459
Ganglioneuroblastoma 40.44 14.48 10 188878 28 110400383
Skin laceration 40.43 14.48 5 188883 33748 110366663
C-reactive protein increased 40.39 14.48 213 188675 217706 110182705
Epstein-Barr virus infection reactivation 40.38 14.48 42 188846 4042 110396369
Post-acute COVID-19 syndrome 40.29 14.48 28 188860 1547 110398864
Gastrointestinal necrosis 40.06 14.48 53 188835 6587 110393824
Primary mediastinal large B-cell lymphoma recurrent 39.84 14.48 13 188875 120 110400291
Small intestinal perforation 39.72 14.48 43 188845 4333 110396078
Throat irritation 39.58 14.48 21 188867 53531 110346880
Xanthogranuloma 39.56 14.48 12 188876 85 110400326
Lipase increased 39.51 14.48 94 188794 18578 110381833
Iron deficiency anaemia 39.51 14.48 4 188884 31555 110368856
Metastasis 39.49 14.48 59 188829 8208 110392203
Immunosuppression 39.32 14.48 91 188797 17668 110382743
Delirium 39.23 14.48 110 188778 134915 110265496
Disseminated cryptococcosis 39.01 14.48 34 188854 2623 110397788
Intracardiac thrombus 38.84 14.48 42 188846 4226 110396185
Nail pigmentation 38.74 14.48 17 188871 373 110400038
Body temperature decreased 38.57 14.48 8 188880 36927 110363484
Osteomyelitis bacterial 38.33 14.48 19 188869 554 110399857
Retinitis 38.21 14.48 5 188883 32322 110368089
Cough 38.04 14.48 557 188331 461084 109939327
Localised infection 38.01 14.48 13 188875 43035 110357376
Sopor 37.99 14.48 8 188880 36538 110363873
Optic glioma 37.97 14.48 11 188877 65 110400346
Pulmonary arteriopathy 37.96 14.48 12 188876 99 110400312
Pulmonary fibrosis 37.79 14.48 73 188815 101969 110298442
Premature menopause 37.64 14.48 23 188865 1019 110399392
Encephalitis cytomegalovirus 37.63 14.48 29 188859 1881 110398530
Eye irritation 37.62 14.48 6 188882 33446 110366965
Retinal haemorrhage 37.34 14.48 62 188826 9439 110390972
Refractory cancer 37.32 14.48 15 188873 262 110400149
Encephalitis viral 37.31 14.48 35 188853 2972 110397439
Decreased appetite 37.21 14.48 580 188308 475266 109925145
Gastric stenosis 37.15 14.48 14 188874 204 110400207
Device issue 37.07 14.48 7 188881 34528 110365883
Hepatic candidiasis 36.95 14.48 12 188876 109 110400302
Mucosal infection 36.79 14.48 18 188870 510 110399901
Seizure 36.73 14.48 556 188332 220629 110179782
Liver function test increased 36.73 14.48 59 188829 88489 110311922
Necrotising gastritis 36.62 14.48 11 188877 75 110400336
Rhinocerebral mucormycosis 36.55 14.48 26 188862 1491 110398920
Eye pain 36.51 14.48 20 188868 50079 110350332
Aeromonas infection 36.50 14.48 18 188870 519 110399892
Adverse reaction 36.41 14.48 4 188884 29590 110370821
Lower respiratory tract infection fungal 36.40 14.48 21 188867 836 110399575
Multiple-drug resistance 36.37 14.48 74 188814 13161 110387250
Ocular hyperaemia 36.22 14.48 11 188877 39275 110361136
Perineal infection 36.17 14.48 21 188867 846 110399565
Viral infection 36.11 14.48 183 188705 52956 110347455
Ureaplasma infection 36.11 14.48 26 188862 1520 110398891
Cerebral toxoplasmosis 36.00 14.48 35 188853 3107 110397304
Myeloproliferative neoplasm 35.99 14.48 25 188863 1380 110399031
Unevaluable event 35.94 14.48 29 188859 59198 110341213
Respiratory tract congestion 35.93 14.48 5 188883 30852 110369559
Chromosomal deletion 35.92 14.48 13 188875 168 110400243
Paraesthesia oral 35.78 14.48 7 188881 33664 110366747
Obstructive airways disorder 35.76 14.48 17 188871 46132 110354279
Flagellate dermatitis 35.69 14.48 15 188873 295 110400116
Lennox-Gastaut syndrome 35.64 14.48 15 188873 296 110400115
Cardio-respiratory arrest 35.43 14.48 92 188796 115744 110284667
Trichosporon infection 35.35 14.48 24 188864 1276 110399135
Metapneumovirus infection 35.33 14.48 31 188857 2413 110397998
Sinus congestion 35.32 14.48 5 188883 30454 110369957
Skin discolouration 35.14 14.48 20 188868 49026 110351385
Neutropenic infection 35.05 14.48 35 188853 3210 110397201
Blood pressure diastolic decreased 35.03 14.48 9 188879 35876 110364535
Disability 34.96 14.48 5 188883 30218 110370193
Trichodysplasia spinulosa 34.95 14.48 22 188866 1028 110399383
Hepatic cytolysis 34.93 14.48 186 188702 54867 110345544
Respiratory arrest 34.81 14.48 29 188859 58270 110342141
Mass 34.40 14.48 92 188796 19538 110380873
Fat embolism syndrome 34.34 14.48 12 188876 139 110400272
Leukoerythroblastosis 34.14 14.48 15 188873 330 110400081
Central nervous system enteroviral infection 34.06 14.48 11 188877 98 110400313
Picornavirus infection 34.03 14.48 12 188876 143 110400268
Therapy cessation 34.03 14.48 17 188871 44840 110355571
Intracranial pressure increased 33.95 14.48 63 188825 10472 110389939
Hepatopulmonary syndrome 33.91 14.48 13 188875 199 110400212
Retinal pigment epitheliopathy 33.76 14.48 17 188871 513 110399898
Gastroenteritis norovirus 33.68 14.48 36 188852 3575 110396836
Chronic myeloid leukaemia 33.66 14.48 39 188849 4234 110396177
Chromosome analysis abnormal 33.51 14.48 14 188874 271 110400140
Administration site extravasation 33.51 14.48 26 188862 1703 110398708
Metastatic lymphoma 33.47 14.48 18 188870 624 110399787
Stenotrophomonas bacteraemia 33.28 14.48 14 188874 276 110400135
Graft versus host disease in gastrointestinal tract 33.22 14.48 57 188831 8911 110391500
Scedosporium infection 33.20 14.48 30 188858 2428 110397983
Hepatic cirrhosis 33.10 14.48 40 188848 67586 110332825
Chylothorax 33.01 14.48 22 188866 1134 110399277
Autonomic neuropathy 32.90 14.48 29 188859 2271 110398140
Nephroblastoma 32.73 14.48 8 188880 21 110400390
Kidney infection 32.69 14.48 3 188885 25596 110374815
Influenza 32.62 14.48 163 188725 168938 110231473
Respiratory tract infection fungal 32.61 14.48 23 188865 1301 110399110
Acute biphenotypic leukaemia 32.61 14.48 12 188876 163 110400248
Rhinorrhoea 32.60 14.48 80 188808 102586 110297825
Pneumothorax spontaneous 32.37 14.48 26 188862 1791 110398620
Lymphoproliferative disorder 32.34 14.48 50 188838 7168 110393243
Ureteric compression 32.21 14.48 14 188874 300 110400111
Diffuse alveolar damage 31.99 14.48 37 188851 4010 110396401
Muscular weakness 31.90 14.48 271 188617 248197 110152214
Temporal lobe epilepsy 31.80 14.48 16 188872 482 110399929
Leukaemic lymphoma 31.80 14.48 10 188878 81 110400330
Tracheo-oesophageal fistula 31.79 14.48 18 188870 691 110399720
Synovial sarcoma 31.69 14.48 10 188878 82 110400329
Transaminases increased 31.65 14.48 201 188687 63189 110337222
Deafness neurosensory 31.59 14.48 58 188830 9561 110390850
Bacillus test positive 31.59 14.48 12 188876 179 110400232
Dyspnoea exertional 31.56 14.48 83 188805 103977 110296434
Blood pressure systolic abnormal 31.50 14.48 3 188885 24847 110375564
Hypophagia 31.50 14.48 175 188713 52451 110347960
Splenic marginal zone lymphoma 31.48 14.48 10 188878 84 110400327
Metastases to spleen 31.44 14.48 19 188869 825 110399586
Histoplasmosis disseminated 31.41 14.48 36 188852 3863 110396548
Neurological symptom 31.34 14.48 77 188811 15531 110384880
Central nervous system fungal infection 31.23 14.48 17 188871 604 110399807
Toxic neuropathy 31.18 14.48 21 188867 1102 110399309
Anisometropia 31.17 14.48 10 188878 87 110400324
Metastases to peritoneum 31.14 14.48 43 188845 5567 110394844
Chemotherapeutic drug level increased 31.09 14.48 16 188872 506 110399905
Drug reaction with eosinophilia and systemic symptoms 31.04 14.48 58 188830 82037 110318374
Blood potassium decreased 31 14.48 28 188860 54086 110346325
Bone marrow infiltration 30.95 14.48 19 188869 849 110399562
Medulloblastoma recurrent 30.93 14.48 12 188876 190 110400221
Tendonitis 30.91 14.48 4 188884 26079 110374332
Jejunal stenosis 30.90 14.48 11 188877 135 110400276
Chronic hepatitis 30.81 14.48 25 188863 1747 110398664
Enterococcus test positive 30.77 14.48 31 188857 2873 110397538
Metastases to bone marrow 30.66 14.48 20 188868 994 110399417
Sinusitis fungal 30.61 14.48 30 188858 2690 110397721
Blood pressure diastolic abnormal 30.50 14.48 4 188884 25811 110374600
Acute lung injury 30.43 14.48 32 188856 3119 110397292
Escherichia test positive 30.42 14.48 34 188854 3550 110396861
Multiple sclerosis 30.32 14.48 4 188884 25694 110374717
Candida sepsis 30.27 14.48 31 188857 2930 110397481
Malnutrition 30.24 14.48 109 188779 27170 110373241
Transverse sinus thrombosis 30.24 14.48 18 188870 760 110399651
Fibrinous bronchitis 30.19 14.48 11 188877 145 110400266
Gastroenteritis viral 30.16 14.48 8 188880 31218 110369193
Candida pneumonia 30.15 14.48 20 188868 1023 110399388
Pneumonia bacterial 30.03 14.48 106 188782 26155 110374256
Electrocardiogram QT prolonged 30.02 14.48 91 188797 108869 110291542
Muscle spasticity 29.77 14.48 12 188876 35903 110364508
Streptococcus test positive 29.73 14.48 29 188859 2585 110397826
Hyperkalaemia 29.70 14.48 125 188763 135671 110264740
Hydrocephalus 29.69 14.48 59 188829 10316 110390095
Ameloblastoma 29.67 14.48 10 188878 103 110400308
Antithrombin III deficiency 29.59 14.48 11 188877 154 110400257
Gastric disorder 29.58 14.48 10 188878 33347 110367064
Herpes zoster meningoencephalitis 29.55 14.48 20 188868 1058 110399353
Liver function test abnormal 29.49 14.48 45 188843 68905 110331506
Accidental overdose 29.48 14.48 27 188861 51807 110348604
Hypersomnia 29.47 14.48 6 188882 28055 110372356
Carotid intima-media thickness increased 29.41 14.48 10 188878 106 110400305
Cryptococcal fungaemia 29.34 14.48 13 188875 292 110400119
Capillary leak syndrome 29.34 14.48 39 188849 4869 110395542
Injection site rash 29.23 14.48 3 188885 23416 110376995
Pneumoperitoneum 29.13 14.48 35 188853 3949 110396462
Plasma cell myeloma 28.97 14.48 39 188849 62897 110337514
Campylobacter gastroenteritis 28.96 14.48 25 188863 1904 110398507
Endometrial adenocarcinoma 28.95 14.48 21 188867 1242 110399169
Diabetic ketoacidosis 28.93 14.48 18 188870 42040 110358371
Mediastinum neoplasm 28.84 14.48 10 188878 113 110400298
Laboratory test abnormal 28.78 14.48 20 188868 44059 110356352
Panic attack 28.75 14.48 7 188881 28933 110371478
Hip fracture 28.72 14.48 12 188876 35139 110365272
Cerebral candidiasis 28.72 14.48 9 188879 72 110400339
Ill-defined disorder 28.67 14.48 154 188734 156699 110243712
Cardiac murmur 28.66 14.48 4 188884 24624 110375787
Extrapyramidal disorder 28.65 14.48 7 188881 28860 110371551
Brain oedema 28.52 14.48 117 188771 30981 110369430
White blood cell count abnormal 28.39 14.48 46 188842 6863 110393548
Molluscum contagiosum 28.22 14.48 16 188872 616 110399795
Blood HIV RNA increased 28.17 14.48 26 188862 2162 110398249
Hyperleukocytosis 28.12 14.48 32 188856 3407 110397004
Epstein Barr virus positive mucocutaneous ulcer 28.11 14.48 20 188868 1147 110399264
Astrocytoma 28.00 14.48 12 188876 248 110400163
Central nervous system neoplasm 27.97 14.48 11 188877 181 110400230
Erythropoiesis abnormal 27.91 14.48 16 188872 629 110399782
Diffuse large B-cell lymphoma stage IV 27.86 14.48 18 188870 880 110399531
Foot fracture 27.81 14.48 5 188883 25541 110374870
Tooth disorder 27.68 14.48 8 188880 29501 110370910
Orthostatic hypotension 27.61 14.48 44 188844 66205 110334206
Pulse waveform abnormal 27.59 14.48 9 188879 83 110400328
Ankle brachial index decreased 27.59 14.48 9 188879 83 110400328
Arrhythmogenic right ventricular dysplasia 27.49 14.48 9 188879 84 110400327
Platelet count abnormal 27.42 14.48 43 188845 6239 110394172
Depressed level of consciousness 27.34 14.48 99 188789 112179 110288232
Delusion 27.31 14.48 4 188884 23751 110376660
Disorder of orbit 27.30 14.48 10 188878 134 110400277
Gastrointestinal inflammation 27.28 14.48 54 188834 9415 110390996
Chronic hepatitis B 27.07 14.48 15 188873 552 110399859
Eyelid ptosis 27.03 14.48 66 188822 13261 110387150
Subacute combined cord degeneration 27.01 14.48 13 188875 355 110400056
Pulmonary toxicity 27.00 14.48 79 188809 17667 110382744
Miosis 26.97 14.48 3 188885 21980 110378431
Disturbance in attention 26.96 14.48 40 188848 61955 110338456
Cardiac ventricular thrombosis 26.96 14.48 30 188858 3117 110397294
Facial paresis 26.90 14.48 42 188846 6071 110394340
Rib fracture 26.85 14.48 12 188876 33758 110366653
Restlessness 26.78 14.48 34 188854 56225 110344186
Femur fracture 26.70 14.48 22 188866 44447 110355964
Chronic lymphocytic leukaemia transformation 26.63 14.48 12 188876 281 110400130
Ear pain 26.57 14.48 31 188857 53195 110347216
Respiratory syncytial virus infection 26.52 14.48 69 188819 14415 110385996
Neutrophil count abnormal 26.51 14.48 38 188850 5094 110395317
Meningitis tuberculous 26.49 14.48 20 188868 1258 110399153
Fear 26.45 14.48 4 188884 23189 110377222
Traumatic lung injury 26.38 14.48 27 188861 2550 110397861
Chloroma 26.32 14.48 17 188871 831 110399580
Lacrimation increased 26.22 14.48 10 188878 30940 110369471
Gastric perforation 26.20 14.48 37 188851 4892 110395519
Positron emission tomogram abnormal 26.06 14.48 14 188874 484 110399927
Mood altered 26.02 14.48 3 188885 21372 110379039
Abortion spontaneous 26.00 14.48 13 188875 34269 110366142
Cerebellar syndrome 25.95 14.48 42 188846 6260 110394151
Movement disorder 25.86 14.48 15 188873 36389 110364022
Herpes virus infection 25.78 14.48 50 188838 8588 110391823
Vocal cord paresis 25.76 14.48 12 188876 304 110400107
Chromosomal mutation 25.75 14.48 8 188880 62 110400349
Klebsiella test positive 25.72 14.48 26 188862 2420 110397991
Cerebral thrombosis 25.70 14.48 26 188862 2422 110397989
Intentional product use issue 25.65 14.48 285 188603 247621 110152790
HCoV-HKU1 infection 25.53 14.48 8 188880 64 110400347
Intestinal atresia 25.53 14.48 8 188880 64 110400347
Product administration error 25.50 14.48 16 188872 37201 110363210
Infantile vomiting 25.42 14.48 8 188880 65 110400346
Tissue infiltration 25.42 14.48 18 188870 1025 110399386
Adenocarcinoma gastric 25.41 14.48 24 188864 2055 110398356
Viral load increased 25.14 14.48 30 188858 3360 110397051
Basal cell naevus syndrome 25.14 14.48 7 188881 35 110400376
Optic atrophy 25.06 14.48 26 188862 2495 110397916
Rash erythematous 25.02 14.48 65 188823 81767 110318644
Neuroblastoma recurrent 25.00 14.48 14 188874 526 110399885
Hepatic infection fungal 24.96 14.48 12 188876 327 110400084
Meningoencephalitis viral 24.88 14.48 14 188874 531 110399880
Myelitis 24.77 14.48 29 188859 3184 110397227
Rash macular 24.67 14.48 18 188870 38668 110361743
Gas gangrene 24.66 14.48 12 188876 336 110400075
Diabetes mellitus inadequate control 24.60 14.48 10 188878 29765 110370646
Quadriparesis 24.53 14.48 35 188853 4672 110395739
Vena cava thrombosis 24.41 14.48 30 188858 3464 110396947
Haemorrhage intracranial 24.25 14.48 106 188782 28863 110371548
Heart rate abnormal 24.22 14.48 44 188844 7194 110393217
Renal replacement therapy 24.21 14.48 10 188878 188 110400223
Thirst 24.17 14.48 4 188884 21703 110378708
Ovarian failure 24.15 14.48 17 188871 959 110399452
Apraxia 24.10 14.48 30 188858 3510 110396901
Hepatic infarction 24.07 14.48 17 188871 964 110399447
Encephalitis enteroviral 24.05 14.48 11 188877 267 110400144
Primary immunodeficiency syndrome 24.04 14.48 8 188880 79 110400332
Pyloric stenosis 24.03 14.48 14 188874 568 110399843
Sinus disorder 23.94 14.48 13 188875 32715 110367696
Marginal zone lymphoma recurrent 23.93 14.48 7 188881 43 110400368
Coronavirus test positive 23.92 14.48 19 188869 1288 110399123
Disseminated toxoplasmosis 23.82 14.48 13 188875 464 110399947
Granulocytopenia 23.72 14.48 61 188827 12654 110387757
Sputum discoloured 23.72 14.48 9 188879 27936 110372475
Graft versus host disease in skin 23.69 14.48 47 188841 8207 110392204
Erythropenia 23.57 14.48 13 188875 474 110399937
Primitive neuroectodermal tumour 23.53 14.48 7 188881 46 110400365
Skin toxicity 23.52 14.48 58 188830 11725 110388686
Lymphocyte count decreased 23.51 14.48 173 188715 57070 110343341
Thrombocytopenia neonatal 23.48 14.48 6 188882 20 110400391
Oesophageal stenosis 23.45 14.48 36 188852 5129 110395282
Drug effective for unapproved indication 23.43 14.48 65 188823 14102 110386309
Mucoepidermoid carcinoma of salivary gland 23.41 14.48 9 188879 139 110400272
Human herpesvirus 7 infection 23.37 14.48 10 188878 206 110400205
Flatulence 23.31 14.48 33 188855 52116 110348295
Cerebral salt-wasting syndrome 23.28 14.48 11 188877 288 110400123
Morphoea 23.25 14.48 14 188874 604 110399807
Abdominal mass 23.23 14.48 35 188853 4906 110395505
Breast cancer 23.23 14.48 19 188869 38523 110361888
Thrombotic microangiopathy 23.15 14.48 105 188783 29044 110371367
Haemolytic uraemic syndrome 22.99 14.48 35 188853 4950 110395461
Drug eruption 22.97 14.48 35 188853 53624 110346787
Paranasal sinus mucosal hypertrophy 22.95 14.48 8 188880 92 110400319
Cytomegalovirus hepatitis 22.92 14.48 16 188872 890 110399521
Obliterative bronchiolitis 22.90 14.48 30 188858 3693 110396718
Therapeutic response delayed 22.89 14.48 19 188869 1371 110399040
Norovirus infection 22.86 14.48 24 188864 2335 110398076
Tooth malformation 22.83 14.48 9 188879 149 110400262
Lymphocytic leukaemia 22.80 14.48 11 188877 302 110400109
Skin haemorrhage 22.80 14.48 7 188881 24820 110375591
Taeniasis 22.79 14.48 7 188881 52 110400359
Feeling cold 22.76 14.48 15 188873 33972 110366439
Anorectal cellulitis 22.71 14.48 8 188880 95 110400316
Lip swelling 22.71 14.48 32 188856 50635 110349776
Campylobacter infection 22.69 14.48 24 188864 2355 110398056
Helicobacter sepsis 22.63 14.48 6 188882 24 110400387
Loss of CAR T-cell persistence 22.63 14.48 6 188882 24 110400387
Device dislocation 22.61 14.48 13 188875 31691 110368720
Emotional distress 22.51 14.48 26 188862 44821 110355590
Restless legs syndrome 22.51 14.48 7 188881 24619 110375792
Leukonychia 22.49 14.48 8 188880 98 110400313
Blood calcium decreased 22.45 14.48 17 188871 35828 110364583
Angioimmunoblastic T-cell lymphoma recurrent 22.43 14.48 6 188882 25 110400386
Hydronephrosis 22.42 14.48 82 188806 20583 110379828
Cellulitis gangrenous 22.36 14.48 12 188876 414 110399997
Premature ageing 22.34 14.48 8 188880 100 110400311
Obstruction gastric 22.29 14.48 22 188866 1989 110398422
Creatinine renal clearance decreased 22.22 14.48 5 188883 21810 110378601
Alpha haemolytic streptococcal infection 22.18 14.48 29 188859 3564 110396847
Renal tubular disorder 22.17 14.48 43 188845 7386 110393025
Plasmablastic lymphoma 22.14 14.48 15 188873 795 110399616
Throat tightness 22.13 14.48 15 188873 33474 110366937
Photosensitivity reaction 22.13 14.48 8 188880 25581 110374830
Basal ganglion degeneration 22.10 14.48 12 188876 424 110399987
Gastrointestinal obstruction 22.08 14.48 23 188865 2217 110398194
Parasitic gastroenteritis 22.08 14.48 10 188878 237 110400174
Pneumococcal bacteraemia 22.04 14.48 10 188878 238 110400173
Diabetes mellitus 22.03 14.48 91 188797 99290 110301121
Blood urine present 21.97 14.48 7 188881 24238 110376173
Listeria sepsis 21.87 14.48 15 188873 811 110399600
Blindness cortical 21.85 14.48 17 188871 1118 110399293
Blood potassium increased 21.83 14.48 15 188873 33234 110367177
Endocarditis 21.77 14.48 61 188827 13310 110387101
Anal inflammation 21.74 14.48 24 188864 2472 110397939
Pneumonia pseudomonal 21.70 14.48 43 188845 7503 110392908
Muscle rigidity 21.67 14.48 7 188881 24024 110376387
Stevens-Johnson syndrome 21.65 14.48 29 188859 46872 110353539
Oxygen saturation decreased 21.61 14.48 168 188720 156814 110243597
Respiratory depression 21.59 14.48 14 188874 31987 110368424
Abdominal distension 21.57 14.48 193 188695 174910 110225501
Herpes simplex encephalitis 21.56 14.48 15 188873 830 110399581
Neuroborreliosis 21.55 14.48 9 188879 174 110400237
Aspiration bone marrow abnormal 21.51 14.48 9 188879 175 110400236
Non-alcoholic steatohepatitis 21.49 14.48 24 188864 2503 110397908
Walking aid user 21.41 14.48 8 188880 25067 110375344
Hepatitis B DNA increased 21.40 14.48 15 188873 840 110399571
Superior vena cava syndrome 21.40 14.48 18 188870 1323 110399088
Ulcer haemorrhage 21.39 14.48 6 188882 22565 110377846
T-cell prolymphocytic leukaemia 21.32 14.48 7 188881 66 110400345
Neurofibrosarcoma 21.30 14.48 10 188878 258 110400153
Infection in an immunocompromised host 21.21 14.48 21 188867 1906 110398505
Hepatitis B surface antigen positive 21.18 14.48 9 188879 182 110400229
Paraplegia 21.14 14.48 38 188850 6162 110394249
Lip scab 21.14 14.48 8 188880 118 110400293
Lumbosacral radiculopathy 21.11 14.48 13 188875 584 110399827
Glycosylated haemoglobin increased 21.08 14.48 7 188881 23612 110376799
Metastases to lymph nodes 21.06 14.48 65 188823 14967 110385444
Ageusia 21.05 14.48 4 188884 19641 110380770
Fracture 21.01 14.48 8 188880 24780 110375631
Paraneoplastic pemphigus 20.96 14.48 9 188879 187 110400224
Diverticulitis 20.96 14.48 37 188851 53485 110346926
Labelled drug-drug interaction medication error 20.92 14.48 12 188876 29290 110371121
Chronic lymphocytic leukaemia refractory 20.90 14.48 8 188880 122 110400289
Renal salt-wasting syndrome 20.89 14.48 15 188873 873 110399538
Cerebellar stroke 20.83 14.48 15 188873 877 110399534
Microgenia 20.77 14.48 5 188883 12 110400399
Pneumonia necrotising 20.77 14.48 20 188868 1755 110398656
Otitis media acute 20.76 14.48 19 188869 1563 110398848
Cataract 20.76 14.48 68 188820 79417 110320994
KMT2A gene mutation 20.63 14.48 6 188882 36 110400375
Vaginal discharge 20.62 14.48 3 188885 17905 110382506
Clostridium bacteraemia 20.61 14.48 12 188876 486 110399925
Necrosis 20.54 14.48 54 188834 11352 110389059
Aggression 20.52 14.48 44 188844 59166 110341245
Congenital herpes simplex infection 20.49 14.48 5 188883 13 110400398
Skin cancer 20.43 14.48 3 188885 17781 110382630
Meningitis bacterial 20.41 14.48 26 188862 3113 110397298
Splenic lesion 20.37 14.48 13 188875 622 110399789
Neurological examination abnormal 20.36 14.48 14 188874 760 110399651
Skin burning sensation 20.32 14.48 6 188882 21819 110378592
Pneumonia adenoviral 20.28 14.48 13 188875 627 110399784
Gastrointestinal fungal infection 20.28 14.48 14 188874 765 110399646
Incorrect route of product administration 20.27 14.48 50 188838 64011 110336400
Mantle cell lymphoma refractory 20.21 14.48 8 188880 134 110400277
Sphingomonas paucimobilis infection 20.21 14.48 8 188880 134 110400277
Candida endophthalmitis 20.20 14.48 9 188879 205 110400206
Blastic plasmacytoid dendritic cell neoplasia 20.20 14.48 7 188881 79 110400332
Spinal stenosis 20.16 14.48 4 188884 19052 110381359
Disseminated aspergillosis 20.15 14.48 23 188865 2457 110397954
Urethral obstruction 20.04 14.48 10 188878 296 110400115
Bile duct necrosis 20.04 14.48 7 188881 81 110400330
Hallucination, auditory 20.03 14.48 10 188878 26387 110374024
Staphylococcus test positive 20.00 14.48 41 188847 7329 110393082
Death 19.91 14.48 983 187905 697886 109702525
Gastric pneumatosis 19.84 14.48 6 188882 42 110400369
Peroneal nerve palsy 19.84 14.48 41 188847 7373 110393038
Blood glucose decreased 19.76 14.48 13 188875 29475 110370936
Sinus tachycardia 19.74 14.48 137 188751 44356 110356055
Bacterial translocation 19.74 14.48 18 188870 1474 110398937
Sleep apnoea syndrome 19.72 14.48 24 188864 40423 110359988
Cholelithiasis 19.68 14.48 50 188838 63372 110337039
Haemoglobin abnormal 19.67 14.48 46 188842 8992 110391419
Fluid replacement 19.66 14.48 15 188873 958 110399453
Septic embolus 19.63 14.48 22 188866 2304 110398107
Pain of skin 19.60 14.48 5 188883 20024 110380387
Metastases to retroperitoneum 19.55 14.48 11 188877 417 110399994
Renal-limited thrombotic microangiopathy 19.55 14.48 12 188876 536 110399875
Splenic candidiasis 19.51 14.48 7 188881 88 110400323
Uterine enlargement 19.50 14.48 15 188873 970 110399441
Metastases to central nervous system 19.49 14.48 84 188804 22733 110377678
Guillain-Barre syndrome 19.48 14.48 51 188837 10693 110389718
Food allergy 19.48 14.48 5 188883 19943 110380468
Pharyngeal inflammation 19.46 14.48 19 188869 1695 110398716
Akathisia 19.40 14.48 3 188885 17110 110383301
Arteriosclerosis 19.38 14.48 9 188879 24758 110375653
Lymphadenitis viral 19.37 14.48 7 188881 90 110400321
Pulmonary mucormycosis 19.35 14.48 21 188867 2122 110398289
Peripheral blood stem cell apheresis 19.34 14.48 8 188880 151 110400260
Poor quality sleep 19.34 14.48 12 188876 28065 110372346
Retinopathy proliferative 19.34 14.48 8 188880 151 110400260
Iron deficiency 19.30 14.48 4 188884 18472 110381939
Poisoning 19.28 14.48 13 188875 29092 110371319
Plasminogen decreased 19.26 14.48 4 188884 3 110400408
Biliary abscess 19.25 14.48 6 188882 47 110400364
Overgrowth fungal 19.24 14.48 8 188880 153 110400258
Thyroid disorder 19.18 14.48 3 188885 16966 110383445
Neuroendocrine carcinoma of the skin 19.18 14.48 19 188869 1726 110398685
Alveolar soft part sarcoma 19.16 14.48 7 188881 93 110400318
Seasonal allergy 19.15 14.48 5 188883 19717 110380694
Dysphonia 19.12 14.48 66 188822 75863 110324548
TP53 gene mutation 19.05 14.48 8 188880 157 110400254
Eye swelling 19.05 14.48 17 188871 33031 110367380
Streptococcal infection 19.04 14.48 51 188837 10839 110389572
Liver tenderness 19.04 14.48 10 188878 330 110400081
Clostridium test positive 19.04 14.48 51 188837 10842 110389569
VIth nerve paralysis 18.98 14.48 19 188869 1748 110398663
Pulmonary sarcoidosis 18.93 14.48 19 188869 1753 110398658
Lymphatic duct injury 18.93 14.48 6 188882 50 110400361
T-cell lymphoma 18.90 14.48 18 188870 1558 110398853
Papillary thyroid cancer 18.87 14.48 24 188864 2870 110397541
Urinary bladder rupture 18.82 14.48 8 188880 162 110400249
Marrow hyperplasia 18.72 14.48 19 188869 1777 110398634
Leukaemic infiltration extramedullary 18.72 14.48 10 188878 342 110400069
High-grade B-cell lymphoma 18.69 14.48 9 188879 246 110400165
Vagus nerve paralysis 18.66 14.48 5 188883 21 110400390
Blood calcium increased 18.65 14.48 4 188884 18036 110382375
Respiratory moniliasis 18.64 14.48 11 188877 457 110399954
Portal vein embolism 18.64 14.48 7 188881 101 110400310
Female genital tract fistula 18.49 14.48 3 188885 16516 110383895
Anaesthesia 18.48 14.48 12 188876 592 110399819
Rhinitis allergic 18.47 14.48 4 188884 17918 110382493
Pseudomonas aeruginosa meningitis 18.45 14.48 7 188881 104 110400307
Refractory cytopenia with multilineage dysplasia 18.43 14.48 9 188879 254 110400157
Microsporidia infection 18.34 14.48 17 188871 1422 110398989
B-lymphocyte count decreased 18.31 14.48 20 188868 2035 110398376
Disseminated blastomycosis 18.28 14.48 11 188877 474 110399937
Hepatic amoebiasis 18.27 14.48 7 188881 107 110400304
Gastrointestinal protozoal infection 18.27 14.48 7 188881 107 110400304
Hepatic lesion 18.23 14.48 43 188845 8450 110391961
Gangrene 18.22 14.48 3 188885 16338 110384073
Vulvovaginitis 18.17 14.48 10 188878 363 110400048
Peritonitis viral 18.14 14.48 6 188882 58 110400353
Retinal toxicity 18.11 14.48 18 188870 1641 110398770
Human herpesvirus 8 infection 18.07 14.48 19 188869 1852 110398559
Growth failure 18.05 14.48 9 188879 266 110400145
General physical health deterioration 18.02 14.48 571 188317 424724 109975687
Generalised tonic-clonic seizure 17.95 14.48 157 188731 54523 110345888
Lymphadenopathy mediastinal 17.93 14.48 33 188855 5451 110394960
Intracranial hypotension 17.88 14.48 12 188876 626 110399785
Metastases to muscle 17.88 14.48 10 188878 375 110400036
Listeriosis 17.82 14.48 23 188865 2791 110397620
Herpes zoster 17.81 14.48 272 188616 108107 110292304
Cancer in remission 17.78 14.48 6 188882 62 110400349
Splenic necrosis 17.76 14.48 8 188880 187 110400224
Oral herpes 17.76 14.48 114 188774 35966 110364445
Musculoskeletal discomfort 17.74 14.48 9 188879 23529 110376882
Salivary hypersecretion 17.73 14.48 4 188884 17417 110382994
Proteus infection 17.73 14.48 23 188865 2805 110397606
Brain injury 17.71 14.48 57 188831 13419 110386992
Diffuse large B-cell lymphoma stage II 17.70 14.48 7 188881 117 110400294
B-cell aplasia 17.66 14.48 10 188878 384 110400027
Toxocariasis 17.64 14.48 5 188883 27 110400384
Natural killer-cell lymphoblastic lymphoma 17.61 14.48 6 188882 64 110400347
Lineage switch leukaemia 17.61 14.48 6 188882 64 110400347
Cancer fatigue 17.61 14.48 10 188878 386 110400025
Hepatic encephalopathy 17.61 14.48 95 188793 28161 110372250
Crying 17.58 14.48 11 188877 25617 110374794
Fungal oesophagitis 17.56 14.48 15 188873 1126 110399285
Pleocytosis 17.53 14.48 18 188870 1706 110398705
Hypotonia 17.53 14.48 63 188825 15682 110384729
Tooth infection 17.49 14.48 8 188880 22208 110378203
Parkinsonism 17.46 14.48 8 188880 22179 110378232
Drug level decreased 17.45 14.48 5 188883 18543 110381868
Toxic erythema of chemotherapy 17.24 14.48 10 188878 402 110400009
Impaired work ability 17.23 14.48 12 188876 26407 110374004
Acute motor-sensory axonal neuropathy 17.23 14.48 11 188877 527 110399884
Streptococcal sepsis 17.19 14.48 31 188857 5041 110395370
Necrotising colitis 17.18 14.48 18 188870 1747 110398664
Angina pectoris 17.18 14.48 52 188836 62243 110338168
Carnitine deficiency 17.14 14.48 9 188879 297 110400114
Pericardial effusion 17.11 14.48 161 188727 57056 110343355
Haemodynamic instability 17.11 14.48 81 188807 22807 110377604
Hypogonadism male 17.09 14.48 8 188880 205 110400206
Blood creatinine increased 17.08 14.48 215 188673 182674 110217737
Nephrolithiasis 17.05 14.48 57 188831 66155 110334256
Blood immunoglobulin G decreased 17.03 14.48 32 188856 5368 110395043
Corynebacterium infection 17.02 14.48 19 188869 1981 110398430
Adenoviral haemorrhagic cystitis 16.96 14.48 12 188876 682 110399729
Administration related reaction 16.89 14.48 9 188879 306 110400105
Endocarditis bacterial 16.84 14.48 18 188870 1787 110398624
IIIrd nerve paralysis 16.83 14.48 16 188872 1381 110399030
Meningitis 16.76 14.48 51 188837 11651 110388760
Ecthyma 16.69 14.48 14 188874 1025 110399386
Pneumonia respiratory syncytial viral 16.68 14.48 22 188866 2727 110397684
Chronic lymphocytic leukaemia recurrent 16.58 14.48 14 188874 1035 110399376
Acute respiratory failure 16.53 14.48 199 188689 75061 110325350
Hypoxia 16.52 14.48 312 188576 129203 110271208
Subileus 16.52 14.48 35 188853 6402 110394009
Acute graft versus host disease in skin 16.52 14.48 48 188840 10692 110389719
Oophoritis 16.50 14.48 7 188881 141 110400270
Central nervous system necrosis 16.49 14.48 10 188878 437 110399974
Acute leukaemia 16.49 14.48 18 188870 1831 110398580
Areflexia 16.45 14.48 36 188852 6733 110393678
Cutaneous mucormycosis 16.42 14.48 12 188876 718 110399693
Thinking abnormal 16.40 14.48 3 188885 15137 110385274
Epidermal necrosis 16.37 14.48 23 188865 3027 110397384
Productive cough 16.36 14.48 121 188767 114184 110286227
Enterococcal sepsis 16.34 14.48 24 188864 3288 110397123
Food protein-induced enterocolitis syndrome 16.29 14.48 5 188883 37 110400374
Stomatitis necrotising 16.28 14.48 8 188880 229 110400182
Chronic graft versus host disease 16.25 14.48 44 188844 9413 110390998
Retinitis viral 16.24 14.48 10 188878 449 110399962
Eosinophilia 16.24 14.48 48 188840 57888 110342523
Meningitis pneumococcal 16.16 14.48 12 188876 736 110399675
Hiatus hernia 16.15 14.48 14 188874 27592 110372819
Vulvovaginal inflammation 16.14 14.48 12 188876 737 110399674
Cerebral hypoperfusion 16.12 14.48 13 188875 901 110399510
Scrotal oedema 16.11 14.48 17 188871 1664 110398747
Myocardial stunning 16.10 14.48 9 188879 337 110400074
Drug tolerance decreased 16.08 14.48 14 188874 27526 110372885
Parasitic pneumonia 16.06 14.48 5 188883 39 110400372
Brain herniation 16.00 14.48 42 188846 8821 110391590
Primary hypogonadism 15.99 14.48 8 188880 238 110400173
Hypertensive crisis 15.99 14.48 11 188877 24361 110376050
Small intestinal obstruction 15.99 14.48 102 188786 32111 110368300
Metapneumovirus bronchiolitis 15.97 14.48 4 188884 12 110400399
Breath sounds abnormal 15.97 14.48 12 188876 25392 110375019
Antithrombin III 15.95 14.48 6 188882 87 110400324
Electrocardiogram abnormal 15.92 14.48 6 188882 18703 110381708
Pulmonary veno-occlusive disease 15.92 14.48 19 188869 2129 110398282
Growth hormone deficiency 15.89 14.48 10 188878 467 110399944
Cardiac sarcoidosis 15.88 14.48 9 188879 346 110400065
Cardiopulmonary failure 15.88 14.48 39 188849 7864 110392547
Emotional disorder 15.88 14.48 4 188884 16156 110384255
Pneumonia toxoplasmal 15.85 14.48 5 188883 41 110400370
Genotoxicity 15.85 14.48 5 188883 41 110400370
Engraftment syndrome 15.84 14.48 18 188870 1914 110398497
Coma 15.83 14.48 127 188761 117742 110282669
Meningoencephalitis herpetic 15.79 14.48 20 188868 2382 110398029
Feeling jittery 15.77 14.48 3 188885 14719 110385692
Bone sarcoma 15.76 14.48 6 188882 90 110400321
Bronchospasm 15.76 14.48 17 188871 30222 110370189
Joint effusion 15.74 14.48 8 188880 20897 110379514
Selective mutism 15.70 14.48 6 188882 91 110400320
Portal hypertension 15.66 14.48 41 188847 8596 110391815
Graft complication 15.65 14.48 14 188874 1118 110399293
Monoparesis 15.65 14.48 28 188860 4525 110395886
Extravasation 15.64 14.48 29 188859 4816 110395595
Neuroblastoma 15.63 14.48 9 188879 357 110400054
Arteriosclerosis coronary artery 15.62 14.48 12 188876 25106 110375305
Splenic infection fungal 15.61 14.48 7 188881 162 110400249
Tachypnoea 15.58 14.48 118 188770 39277 110361134
Rectal fissure 15.52 14.48 14 188874 1130 110399281
Herpes simplex test positive 15.49 14.48 11 188877 629 110399782
Drug dose omission by device 15.46 14.48 3 188885 14513 110385898
Rosai-Dorfman syndrome 15.34 14.48 5 188883 46 110400365
Cutaneous T-cell lymphoma recurrent 15.30 14.48 6 188882 98 110400313
Abnormal behaviour 15.27 14.48 27 188861 39012 110361399
Dementia 15.22 14.48 19 188869 31654 110368757
Rales 15.15 14.48 12 188876 24727 110375684
Tessellated fundus 15.15 14.48 5 188883 48 110400363
Hyperglycaemic hyperosmolar nonketotic syndrome 15.13 14.48 22 188866 2987 110397424
White matter lesion 15.12 14.48 21 188867 2733 110397678
Beta 2 microglobulin decreased 15.09 14.48 4 188884 16 110400395
Intervertebral disc protrusion 15.08 14.48 15 188873 27683 110372728
Oral disorder 15.08 14.48 50 188838 11953 110388458
Inferior vena caval occlusion 15.08 14.48 6 188882 102 110400309
Scopulariopsis infection 15.08 14.48 7 188881 176 110400235
Acral lentiginous melanoma 15.06 14.48 5 188883 49 110400362
Post procedural complication 15.02 14.48 14 188874 26644 110373767
Hepatic function abnormal 15.02 14.48 225 188663 89070 110311341
Blindness 15.00 14.48 110 188778 36249 110364162
Anisocytosis 14.99 14.48 14 188874 1182 110399229
Aborted pregnancy 14.97 14.48 5 188883 50 110400361
Diverticulum 14.95 14.48 4 188884 15522 110384889
Transplant rejection 14.94 14.48 12 188876 24555 110375856
Bladder cancer 14.93 14.48 8 188880 20284 110380127
Pelvic fracture 14.92 14.48 3 188885 14151 110386260
Partial seizures 14.91 14.48 48 188840 11301 110389110
Treatment failure 14.88 14.48 360 188528 276874 110123537
Deep vein thrombosis 14.88 14.48 328 188560 139559 110260852
Toxic leukoencephalopathy 14.87 14.48 16 188872 1601 110398810
Pericardial effusion malignant 14.86 14.48 8 188880 278 110400133
Anaemia megaloblastic 14.81 14.48 12 188876 837 110399574
Facial paralysis 14.81 14.48 81 188807 24133 110376278
Adenovirus test positive 14.76 14.48 6 188882 108 110400303
Head discomfort 14.72 14.48 7 188881 18993 110381418
Leukaemic infiltration 14.69 14.48 7 188881 187 110400224
Hepatitis G 14.66 14.48 6 188882 110 110400301
Hepatic angiosarcoma 14.66 14.48 6 188882 110 110400301
Drug tolerance 14.66 14.48 5 188883 16580 110383831
Urethritis 14.65 14.48 11 188877 686 110399725
Central nervous system lesion 14.65 14.48 59 188829 15494 110384917
Arterial occlusive disease 14.64 14.48 4 188884 15304 110385107
Pericardial calcification 14.62 14.48 5 188883 54 110400357
Gout 14.57 14.48 25 188863 36541 110363870
Pneumaturia 14.54 14.48 5 188883 55 110400356
Eye opacity 14.53 14.48 4 188884 19 110400392
Eustachian tube dysfunction 14.52 14.48 11 188877 695 110399716
T-cell lymphoma refractory 14.51 14.48 6 188882 113 110400298
Coordination abnormal 14.51 14.48 13 188875 25215 110375196
Anaphylactic reaction 14.51 14.48 125 188763 114175 110286236

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01CA02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Vinca alkaloids and analogues
FDA CS M0022674 Vinca Alkaloids
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000972 Antineoplastic Agents, Phytogenic
MeSH PA D050256 Antimitotic Agents
MeSH PA D050257 Tubulin Modulators
FDA EPC N0000175612 Vinca Alkaloid
CHEBI has role CHEBI:23888 drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:60832 tubulin modulator
CHEBI has role CHEBI:61951 microtubule-destabilising agent
CHEBI has role CHEBI:76924 plant metabolite
CHEBI has role CHEBI:176497 geroprotector

Related Drugs by ATC class:

L01CA Vinca alkaloids and analogues 5 drugs
vinblastinevindesinevinfluninevinorelbinevintafolide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acute lymphoid leukemia indication 91857003 DOID:9952
Diffuse non-Hodgkin's lymphoma, large cell indication 109969005
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Rhabdomyosarcoma indication 302847003 DOID:3247
Nephroblastoma indication 302849000 DOID:2154
Follicular non-Hodgkin's lymphoma indication 308121000
Neuroblastoma indication 432328008 DOID:769
Astrocytoma, anaplastic off-label use 55353007 DOID:3078
Ewing's sarcoma off-label use 76909002 DOID:3369
Chronic lymphoid leukemia, disease off-label use 92814006
Multiple myeloma off-label use 109989006 DOID:9538
Mycosis fungoides off-label use 118618005
Small cell carcinoma of lung off-label use 254632001 DOID:5409
Glioblastoma multiforme of brain off-label use 276828006 DOID:3073
Primary cutaneous T-cell lymphoma off-label use 400122007
Ovarian Germ Cell Tumor Carcinoma off-label use
Mycosis contraindication 3218000 DOID:1564
Hyperbilirubinemia contraindication 14783006 DOID:2741
Obstruction of bile duct contraindication 30144000
Viral disease contraindication 34014006 DOID:934
Hyperuricemia contraindication 35885006 DOID:1920
Charcot-Marie-Tooth disease contraindication 50548001
Hepatic failure contraindication 59927004
Leukopenia contraindication 84828003 DOID:615
Bacterial infectious disease contraindication 87628006
Peripheral motor neuropathy contraindication 95663000 DOID:683
Neuromyopathy contraindication 255522009 DOID:440
Uric acid renal calculus contraindication 274401005
Pregnancy, function contraindication 289908002
Peripheral nerve disease contraindication 302226006
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Protozoal Infection contraindication
Polyneuropathies contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.02 acidic
pKa2 13.81 acidic
pKa3 7.2 Basic
pKa4 6.58 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Tubulin beta Tumour-associated antigen INHIBITOR SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Multidrug resistance protein 1 Transporter WOMBAT-PK
Canalicular multispecific organic anion transporter 1 Transporter WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter WOMBAT-PK
Multidrug resistance-associated protein 7 Transporter WOMBAT-PK
Tubulin Structural IC50 5.74 CHEMBL

External reference:

IDSource
4019971 VUID
N0000148056 NUI
D02197 KEGG_DRUG
2068-78-2 SECONDARY_CAS_RN
4017542 VANDF
4019971 VANDF
C0042679 UMLSCUI
CHEBI:28445 CHEBI
R1Q PDB_CHEM_ID
CHEMBL90555 ChEMBL_ID
CHEMBL501867 ChEMBL_ID
D014750 MESH_DESCRIPTOR_UI
DB00541 DRUGBANK_ID
6785 IUPHAR_LIGAND_ID
1440 INN_ID
5J49Q6B70F UNII
5978 PUBCHEM_CID
11202 RXNORM
5133 MMSL
5675 MMSL
7308 MMSL
879 MMSL
d00401 MMSL
002656 NDDF
004894 NDDF
23079006 SNOMEDCT_US
387126006 SNOMEDCT_US
387427007 SNOMEDCT_US
5J49Q6B70F INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
VinCRIStine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 61703-309 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 22 sections
VinCRIStine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 61703-309 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 22 sections