vincristine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
vinca alkaloids 2825 57-22-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vincristine
  • (+)-Vincristine
  • leucristine
  • vincristin
  • vinkristin
  • 22-oxo-vincaleukoblastine
  • vincristine sulfate
  • oncovin
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
  • Molecular weight: 824.97
  • Formula: C46H56N4O10
  • CLOGP: 3.07
  • LIPINSKI: 2
  • HAC: 14
  • HDO: 3
  • TPSA: 171.17
  • ALOGS: -4.44
  • ROTB: 10
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 15 % Benet LZ, Broccatelli F, Oprea TI
Vd (Volume of distribution) 2.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.40 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 23 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 10, 1963 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 4816.95 15.32 2412 66778 116037 63303795
Neutropenia 1580.12 15.32 1394 67796 173611 63246221
Disease progression 1130.60 15.32 990 68200 121768 63298064
Febrile bone marrow aplasia 869.82 15.32 320 68870 7005 63412827
Haematotoxicity 820.74 15.32 328 68862 9048 63410784
Pancytopenia 793.47 15.32 732 68458 96201 63323631
Diffuse large B-cell lymphoma recurrent 752.02 15.32 217 68973 2103 63417729
Product use in unapproved indication 643.94 15.32 880 68310 178200 63241632
Bone marrow failure 606.48 15.32 385 68805 28905 63390927
Thrombocytopenia 586.35 15.32 771 68419 150386 63269446
Mucosal inflammation 565.68 15.32 443 68747 46485 63373347
Second primary malignancy 536.37 15.32 231 68959 7722 63412110
Myelosuppression 511.81 15.32 320 68870 23383 63396449
Venoocclusive liver disease 507.48 15.32 193 68997 4642 63415190
Hepatitis B reactivation 501.64 15.32 171 69019 2966 63416866
Acute myeloid leukaemia 486.32 15.32 276 68914 16871 63402961
Myelodysplastic syndrome 484.15 15.32 273 68917 16481 63403351
Off label use 469.83 15.32 1703 67487 672759 62747073
Posterior reversible encephalopathy syndrome 456.70 15.32 266 68924 17079 63402753
Sepsis 455.44 15.32 688 68502 152435 63267397
Tumour lysis syndrome 437.61 15.32 208 68982 8782 63411050
Septic shock 426.31 15.32 440 68750 66189 63353643
Pain 392.89 15.32 159 69031 740469 62679363
Hypofibrinogenaemia 363.92 15.32 106 69084 1064 63418768
Disease recurrence 327.70 15.32 260 68930 27770 63392062
Ovarian failure 326.41 15.32 100 69090 1210 63418622
Cardiotoxicity 312.12 15.32 162 69028 8276 63411556
Acute lymphocytic leukaemia recurrent 302.45 15.32 108 69082 2161 63417671
Neurotoxicity 301.86 15.32 203 68987 16787 63403045
Joint swelling 298.60 15.32 14 69176 327652 63092180
Neuropathy peripheral 297.69 15.32 482 68708 113185 63306647
Neoplasm progression 295.41 15.32 274 68916 36154 63383678
Pyrexia 293.82 15.32 1149 68041 469329 62950503
Diffuse large B-cell lymphoma refractory 285.81 15.32 89 69101 1141 63418691
Multiple organ dysfunction syndrome 276.57 15.32 325 68865 56427 63363405
Cytopenia 271.67 15.32 165 69025 11436 63408396
Therapy partial responder 271.43 15.32 160 69030 10498 63409334
Rheumatoid arthritis 260.58 15.32 3 69187 253816 63166016
Staphylococcal bacteraemia 260.15 15.32 125 69065 5405 63414427
Abdominal discomfort 259.51 15.32 25 69165 320860 63098972
Neutropenic sepsis 246.53 15.32 177 69013 16261 63403571
Leukopenia 243.34 15.32 357 68833 76933 63342899
Pruritus 231.46 15.32 55 69135 361398 63058434
Arthralgia 228.26 15.32 173 69017 569537 62850295
Arthropathy 227.81 15.32 6 69184 234786 63185046
Malignant neoplasm progression 218.67 15.32 351 68839 81770 63338062
Nasopharyngitis 215.95 15.32 16 69174 254241 63165591
Neutropenic colitis 215.58 15.32 92 69098 3003 63416829
Blood lactate dehydrogenase increased 213.24 15.32 187 69003 22929 63396903
Systemic lupus erythematosus 212.06 15.32 3 69187 208915 63210917
Swelling 206.23 15.32 28 69162 275350 63144482
Contraindicated product administered 205.92 15.32 7 69183 217641 63202191
Haemophagocytic lymphohistiocytosis 205.78 15.32 134 69056 10493 63409339
Drug resistance 204.52 15.32 182 69008 22751 63397081
Product dose omission issue 201.13 15.32 14 69176 234299 63185533
Fall 196.59 15.32 91 69099 392243 63027589
Anaemia 194.39 15.32 731 68459 292699 63127133
Fatigue 194.36 15.32 426 68764 887602 62532230
Neutrophil count decreased 192.83 15.32 271 68919 56135 63363697
Aplasia 190.47 15.32 93 69097 4166 63415666
Synovitis 188.34 15.32 3 69187 186915 63232917
Peripheral swelling 181.31 15.32 35 69155 265907 63153925
Rash 180.21 15.32 208 68982 560663 62859169
Progressive multifocal leukoencephalopathy 179.38 15.32 133 69057 12838 63406994
Platelet count decreased 178.27 15.32 392 68798 115730 63304102
Lymphoma 173.12 15.32 127 69063 12060 63407772
Weight increased 170.19 15.32 38 69152 260754 63159078
Post transplant lymphoproliferative disorder 170.18 15.32 91 69099 4940 63414892
Cardiomyopathy 167.72 15.32 145 69045 17439 63402393
Headache 167.07 15.32 271 68919 632970 62786862
Epstein-Barr virus infection 166.97 15.32 106 69084 7944 63411888
Hypertriglyceridaemia 164.74 15.32 96 69094 6163 63413669
Diffuse large B-cell lymphoma 163.69 15.32 98 69092 6614 63413218
Maternal exposure before pregnancy 162.41 15.32 102 69088 7501 63412331
Hepatitis B 160.83 15.32 80 69110 3732 63416100
Hyperbilirubinaemia 158.68 15.32 117 69073 11197 63408635
Musculoskeletal stiffness 158.49 15.32 11 69179 184607 63235225
Wound 155.28 15.32 5 69185 163258 63256574
B-cell lymphoma recurrent 153.52 15.32 43 69147 370 63419462
Hypogammaglobulinaemia 150.36 15.32 95 69095 7060 63412772
Neoplasm recurrence 150.02 15.32 68 69122 2570 63417262
Dizziness 149.57 15.32 149 69041 429776 62990056
Therapeutic product effect decreased 146.10 15.32 19 69171 193168 63226664
Pneumocystis jirovecii pneumonia 144.42 15.32 131 69059 16783 63403049
Pneumatosis intestinalis 142.95 15.32 64 69126 2349 63417483
Malaise 138.08 15.32 150 69040 415804 63004028
Drug hypersensitivity 137.96 15.32 84 69106 310603 63109229
Drug intolerance 137.69 15.32 83 69107 308578 63111254
Polyneuropathy 136.51 15.32 119 69071 14470 63405362
Bacteraemia 135.80 15.32 128 69062 17220 63402612
Discomfort 135.28 15.32 13 69177 167361 63252471
Sinusitis 134.49 15.32 40 69150 226613 63193219
Cytokine release syndrome 132.41 15.32 116 69074 14198 63405634
Insomnia 131.39 15.32 36 69154 215216 63204616
Anxiety 127.97 15.32 39 69151 217502 63202330
Ileus paralytic 122.95 15.32 71 69119 4480 63415352
Feeling abnormal 121.31 15.32 11 69179 148381 63271451
Respiratory failure 119.66 15.32 310 68880 101548 63318284
Secondary immunodeficiency 119.65 15.32 48 69142 1335 63418497
Dyspnoea 118.90 15.32 350 68840 660963 62758869
Injection site pain 116.63 15.32 6 69184 129794 63290038
Clostridium difficile colitis 115.77 15.32 127 69063 20442 63399390
Blood culture positive 112.53 15.32 68 69122 4667 63415165
Bone pain 110.62 15.32 207 68983 54434 63365398
Systemic candida 110.61 15.32 59 69131 3186 63416646
Leukoencephalopathy 109.09 15.32 65 69125 4348 63415484
Mucormycosis 108.69 15.32 56 69134 2815 63417017
Lennox-Gastaut syndrome 108.28 15.32 30 69160 247 63419585
Hepatic enzyme increased 107.43 15.32 43 69147 202285 63217547
Blood pressure increased 106.90 15.32 23 69167 162039 63257793
Hepatocellular injury 106.34 15.32 140 69050 27241 63392591
Asthma 105.50 15.32 9 69181 127552 63292280
Escherichia bacteraemia 103.36 15.32 60 69130 3823 63416009
Contusion 101.64 15.32 20 69170 150024 63269808
Hypersensitivity 101.02 15.32 102 69088 292583 63127249
Ascites 98.78 15.32 167 69023 40561 63379271
Rhinovirus infection 97.34 15.32 61 69129 4468 63415364
Smooth muscle cell neoplasm 97.07 15.32 36 69154 805 63419027
Pericarditis 96.94 15.32 14 69176 131565 63288267
Alopecia 96.91 15.32 136 69054 337400 63082432
Lymphadenopathy 92.36 15.32 157 69033 38301 63381531
Urticaria 91.74 15.32 33 69157 165769 63254063
Lymphopenia 90.95 15.32 106 69084 18221 63401611
Acute lymphocytic leukaemia 89.31 15.32 47 69143 2469 63417363
Arthritis 88.58 15.32 11 69179 115910 63303922
Temporal lobe epilepsy 88.24 15.32 28 69162 383 63419449
Ototoxicity 86.71 15.32 38 69152 1324 63418508
Klebsiella infection 86.50 15.32 73 69117 8493 63411339
Agranulocytosis 86.21 15.32 121 69069 25013 63394819
Disseminated intravascular coagulation 86.00 15.32 105 69085 18946 63400886
Enterococcal infection 85.74 15.32 70 69120 7778 63412054
Peripheral motor neuropathy 85.18 15.32 40 69150 1641 63418191
Pain in extremity 85.15 15.32 144 69046 331342 63088490
Ejection fraction decreased 84.89 15.32 113 69077 22219 63397613
Inappropriate schedule of product administration 84.18 15.32 8 69182 103957 63315875
Psoriatic arthropathy 82.94 15.32 4 69186 91516 63328316
Psoriasis 81.47 15.32 3 69187 86954 63332878
Enterococcal bacteraemia 81.05 15.32 37 69153 1422 63418410
Superior sagittal sinus thrombosis 80.93 15.32 31 69159 760 63419072
Bronchopulmonary aspergillosis 79.91 15.32 70 69120 8565 63411267
Aspergillus infection 79.74 15.32 68 69122 8025 63411807
White blood cell count decreased 77.75 15.32 329 68861 138775 63281057
Blister 76.79 15.32 23 69167 129791 63290041
Irritable bowel syndrome 76.67 15.32 3 69187 82409 63337423
Overdose 76.55 15.32 16 69174 115062 63304770
Duodenal ulcer perforation 75.37 15.32 5 69185 87204 63332628
Muscle spasms 75.33 15.32 38 69152 156112 63263720
Cystitis haemorrhagic 74.98 15.32 50 69140 4073 63415759
Venoocclusive disease 74.63 15.32 39 69151 2019 63417813
Gene mutation 73.38 15.32 36 69154 1629 63418203
Impaired healing 73.05 15.32 12 69178 102530 63317302
Mobility decreased 72.52 15.32 21 69169 121138 63298694
Migraine 71.63 15.32 13 69177 103333 63316499
Infusion related reaction 71.34 15.32 98 69092 245423 63174409
Colitis 71.21 15.32 161 69029 48367 63371465
Central nervous system lymphoma 70.79 15.32 34 69156 1468 63418364
Cardiac failure 70.76 15.32 236 68954 88906 63330926
Bronchitis 70.59 15.32 24 69166 124911 63294921
Loss of personal independence in daily activities 70.17 15.32 11 69179 97279 63322553
Peripheral sensory neuropathy 70.15 15.32 61 69129 7390 63412442
Cervix disorder 70.12 15.32 26 69164 581 63419251
Staphylococcal sepsis 69.47 15.32 63 69127 8065 63411767
Myeloid leukaemia 68.99 15.32 23 69167 371 63419461
Mantle cell lymphoma recurrent 68.72 15.32 20 69170 200 63419632
Cerebral venous thrombosis 68.70 15.32 37 69153 2037 63417795
Herpes simplex 68.53 15.32 63 69127 8208 63411624
Leukaemia recurrent 68.30 15.32 32 69158 1306 63418526
Myelopathy 68.23 15.32 41 69149 2785 63417047
Aplastic anaemia 68.08 15.32 67 69123 9502 63410330
Human bocavirus infection 67.93 15.32 23 69167 390 63419442
Abdominal pain upper 66.66 15.32 76 69114 206368 63213464
Human herpesvirus 6 infection 66.51 15.32 41 69149 2916 63416916
Pleural effusion 66.35 15.32 238 68952 92972 63326860
Enterobacter infection 66.23 15.32 37 69153 2190 63417642
Helicobacter infection 65.77 15.32 11 69179 92774 63327058
Injection site erythema 65.77 15.32 7 69183 83167 63336665
Bacterial infection 65.58 15.32 93 69097 19406 63400426
Enterovirus test positive 65.42 15.32 18 69172 144 63419688
Congestive cardiomyopathy 65.15 15.32 54 69136 6128 63413704
Pseudomonas test positive 64.84 15.32 26 69164 722 63419110
Wheezing 64.18 15.32 13 69177 95582 63324250
Vasogenic cerebral oedema 63.61 15.32 27 69163 869 63418963
JC virus infection 63.53 15.32 35 69155 2016 63417816
Respiratory distress 63.02 15.32 124 69066 33827 63386005
Chest pain 62.93 15.32 86 69104 215873 63203959
Human rhinovirus test positive 62.30 15.32 18 69172 175 63419657
Cytomegalovirus chorioretinitis 62.24 15.32 33 69157 1760 63418072
Device related infection 62.21 15.32 100 69090 23292 63396540
Quadriplegia 62.12 15.32 33 69157 1767 63418065
Osteoarthritis 61.90 15.32 14 69176 95329 63324503
Lower respiratory tract infection 61.15 15.32 34 69156 132273 63287559
Injury 61.01 15.32 5 69185 73242 63346590
Fungaemia 60.98 15.32 36 69154 2367 63417465
Cardiomyopathy acute 60.98 15.32 19 69171 244 63419588
Blood cholesterol increased 60.66 15.32 14 69176 94018 63325814
Lymphoma transformation 60.41 15.32 17 69173 149 63419683
Cutaneous calcification 60.27 15.32 16 69174 110 63419722
Diarrhoea 59.89 15.32 496 68694 714870 62704962
Vocal cord paralysis 58.56 15.32 34 69156 2167 63417665
Ileus 58.27 15.32 76 69114 14649 63405183
Acute hepatic failure 58.11 15.32 85 69105 18242 63401590
Epstein-Barr virus associated lymphoproliferative disorder 57.78 15.32 32 69158 1862 63417970
Palpitations 56.58 15.32 26 69164 112744 63307088
Cerebral venous sinus thrombosis 56.58 15.32 32 69158 1940 63417892
Hepatic failure 56.49 15.32 122 69068 35534 63384298
Pneumocystis jirovecii infection 56.33 15.32 29 69161 1455 63418377
Cytomegalovirus infection 54.94 15.32 89 69101 20863 63398969
Refractory anaemia with an excess of blasts 54.79 15.32 20 69170 427 63419405
Gastrosplenic fistula 54.44 15.32 13 69177 54 63419778
Fusarium infection 54.43 15.32 22 69168 624 63419208
Pyomyositis 54.36 15.32 19 69171 356 63419476
Venous thrombosis 54.13 15.32 44 69146 4858 63414974
Premature menopause 54.08 15.32 24 69166 862 63418970
Left ventricular dysfunction 53.99 15.32 66 69124 11922 63407910
Glioma 53.34 15.32 18 69172 302 63419530
Condition aggravated 52.86 15.32 242 68948 401975 63017857
Hepatomegaly 52.81 15.32 65 69125 11824 63408008
Perineal infection 52.76 15.32 15 69175 137 63419695
Hospitalisation 52.30 15.32 14 69176 85067 63334765
Neck pain 51.93 15.32 7 69183 69311 63350521
Epstein-Barr virus associated lymphoma 51.92 15.32 20 69170 498 63419334
Hyperpyrexia 51.92 15.32 38 69152 3594 63416238
Injection site reaction 51.64 15.32 3 69187 58521 63361311
Cholestasis 51.63 15.32 105 69085 29329 63390503
Hypoalbuminaemia 51.56 15.32 64 69126 11741 63408091
Intentional product misuse 51.18 15.32 4 69186 60913 63358919
Adverse drug reaction 51.16 15.32 12 69178 79702 63340130
Perineal necrosis 50.77 15.32 14 69176 113 63419719
Depression 50.72 15.32 85 69105 196407 63223425
Nausea 49.94 15.32 645 68545 853826 62566006
COVID-19 pneumonia 49.61 15.32 69 69121 14140 63405692
Pulmonary haemorrhage 48.72 15.32 49 69141 7132 63412700
Blood fibrinogen decreased 48.54 15.32 22 69168 831 63419001
Antithrombin III decreased 48.53 15.32 16 69174 249 63419583
B-cell lymphoma refractory 48.52 15.32 13 69177 93 63419739
Hepatitis E 48.50 15.32 26 69164 1418 63418414
Heart rate abnormal 47.58 15.32 41 69149 4906 63414926
Dry mouth 47.50 15.32 13 69177 77850 63341982
Varicella zoster virus infection 47.44 15.32 32 69158 2657 63417175
Gastroenteritis norovirus 47.35 15.32 29 69161 2039 63417793
Influenza like illness 47.19 15.32 8 69182 66816 63353016
Encephalopathy 46.82 15.32 119 69071 38501 63381331
Acute promyelocytic leukaemia 46.79 15.32 22 69168 905 63418927
Hyperglycaemia 46.65 15.32 125 69065 41742 63378090
Inappropriate antidiuretic hormone secretion 46.56 15.32 70 69120 15392 63404440
B precursor type acute leukaemia 46.44 15.32 15 69175 218 63419614
Confusional state 46.07 15.32 120 69070 236260 63183572
Philadelphia chromosome positive 45.47 15.32 17 69173 389 63419443
Bacterial sepsis 44.71 15.32 36 69154 3922 63415910
Acute hepatitis B 44.21 15.32 16 69174 333 63419499
Ureaplasma infection 44.18 15.32 19 69171 632 63419200
Osteomyelitis bacterial 43.89 15.32 14 69176 195 63419637
Candida infection 43.76 15.32 96 69094 28255 63391577
Jugular vein thrombosis 43.17 15.32 32 69158 3086 63416746
Mucosal toxicity 42.92 15.32 16 69174 363 63419469
Combined immunodeficiency 42.87 15.32 12 69178 103 63419729
5q minus syndrome 42.81 15.32 14 69176 212 63419620
Staphylococcal infection 42.81 15.32 120 69070 41136 63378696
Babesiosis 42.63 15.32 14 69176 215 63419617
Herpes zoster meningoencephalitis 42.53 15.32 15 69175 289 63419543
Erythropoiesis abnormal 42.29 15.32 15 69175 294 63419538
Klebsiella bacteraemia 42.22 15.32 25 69165 1653 63418179
Sleep disorder 42.18 15.32 18 69172 81548 63338284
Lymphadenitis 41.77 15.32 32 69158 3243 63416589
Klebsiella test positive 41.64 15.32 22 69168 1165 63418667
Intestinal perforation 41.63 15.32 58 69132 11905 63407927
Myocardial infarction 41.55 15.32 29 69161 99864 63319968
Neutropenic infection 41.44 15.32 23 69167 1344 63418488
Chronic myelomonocytic leukaemia 40.93 15.32 15 69175 324 63419508
Humoral immune defect 40.63 15.32 14 69176 251 63419581
Synovial sarcoma 40.37 15.32 10 69180 50 63419782
Injection site swelling 40.31 15.32 3 69187 47569 63372263
Transverse sinus thrombosis 40.23 15.32 17 69173 541 63419291
Oedema peripheral 40.23 15.32 92 69098 189419 63230413
Back pain 40.22 15.32 150 69040 263995 63155837
Splenomegaly 40.18 15.32 55 69135 11102 63408730
Hepatotoxicity 39.67 15.32 109 69081 36932 63382900
Haemorrhage intracranial 39.34 15.32 60 69130 13359 63406473
Metastases to meninges 38.96 15.32 28 69162 2574 63417258
Platelet count abnormal 38.85 15.32 31 69159 3333 63416499
Stomatitis 38.45 15.32 271 68919 138454 63281378
Hepatic cytolysis 38.44 15.32 64 69126 15343 63404489
Histiocytic sarcoma 38.42 15.32 10 69180 63 63419769
Tissue infiltration 38.27 15.32 17 69173 612 63419220
Leukoerythroblastosis 38.10 15.32 13 69177 226 63419606
Feeling hot 37.92 15.32 5 69185 50349 63369483
Injection site pruritus 37.79 15.32 3 69187 45113 63374719
Gastrointestinal necrosis 37.14 15.32 28 69162 2770 63417062
Clostridium difficile infection 37.10 15.32 93 69097 29829 63390003
Therapy responder 37.10 15.32 14 69176 329 63419503
Suicidal ideation 37.01 15.32 11 69179 62410 63357422
Gastrooesophageal reflux disease 36.91 15.32 30 69160 95609 63324223
Retinal pigment epitheliopathy 36.88 15.32 13 69177 250 63419582
Unmasking of previously unidentified disease 36.84 15.32 19 69171 957 63418875
Nail pigmentation 36.80 15.32 12 69178 180 63419652
Blood glucose increased 36.61 15.32 23 69167 83733 63336099
Incorrect dose administered 36.60 15.32 10 69180 59958 63359874
Vision blurred 36.52 15.32 28 69162 91896 63327936
Cytomegalovirus infection reactivation 36.41 15.32 32 69158 3931 63415901
Hot flush 36.40 15.32 6 69184 51153 63368679
Leukaemic lymphoma 36.34 15.32 10 69180 80 63419752
Bone marrow disorder 36.20 15.32 26 69164 2388 63417444
Metastases to peritoneum 36.13 15.32 30 69160 3412 63416420
Escherichia infection 35.95 15.32 56 69134 12698 63407134
Drug abuse 35.94 15.32 17 69173 72501 63347331
Cytomegalovirus viraemia 35.52 15.32 37 69153 5612 63414220
Intussusception 35.36 15.32 16 69174 602 63419230
Neurological symptom 34.80 15.32 37 69153 5746 63414086
Joint stiffness 34.48 15.32 3 69187 41866 63377966
Malignant transformation 34.44 15.32 14 69176 403 63419429
Loss of consciousness 34.42 15.32 47 69143 118074 63301758
Cystitis bacterial 34.37 15.32 12 69178 224 63419608
Illness 34.36 15.32 6 69184 49053 63370779
Glioblastoma multiforme 34.31 15.32 17 69173 786 63419046
Antithrombin III 34.30 15.32 11 69179 156 63419676
Therapeutic response delayed 34.26 15.32 16 69174 648 63419184
Platelet transfusion 34.25 15.32 17 69173 789 63419043
Myeloproliferative neoplasm 34.14 15.32 15 69175 526 63419306
Pseudomonas infection 34.10 15.32 51 69139 11162 63408670
Toxic neuropathy 34.09 15.32 14 69176 414 63419418
Hepatic infarction 33.90 15.32 16 69174 664 63419168
Potentiating drug interaction 33.82 15.32 32 69158 4324 63415508
Clostridium test positive 33.81 15.32 28 69162 3173 63416659
Cryptococcosis 33.80 15.32 19 69171 1138 63418694
Basal ganglion degeneration 33.47 15.32 14 69176 434 63419398
Salivary gland cancer 33.43 15.32 11 69179 170 63419662
Gait disturbance 33.42 15.32 96 69094 183082 63236750
Streptococcal bacteraemia 33.40 15.32 22 69168 1755 63418077
Burning sensation 33.34 15.32 9 69181 54398 63365434
Lung infiltration 33.34 15.32 58 69132 14405 63405427
Necrotising gastritis 33.28 15.32 9 69181 67 63419765
Adverse event 33.23 15.32 16 69174 67543 63352289
BK virus infection 33.22 15.32 28 69162 3251 63416581
Infection reactivation 33.17 15.32 19 69171 1180 63418652
Musculoskeletal pain 33.12 15.32 31 69159 92246 63327586
Pneumonia fungal 33 15.32 35 69155 5420 63414412
Myalgia 32.85 15.32 69 69121 146460 63273372
Acute biphenotypic leukaemia 32.82 15.32 9 69181 71 63419761
Chest discomfort 32.81 15.32 43 69147 109926 63309906
Depressed mood 32.77 15.32 3 69187 40188 63379644
Acute myelomonocytic leukaemia 32.74 15.32 11 69179 182 63419650
Pseudomonal bacteraemia 32.67 15.32 21 69169 1607 63418225
Cerebrovascular accident 32.48 15.32 42 69148 107982 63311850
Strongyloidiasis 32.46 15.32 19 69171 1229 63418603
Suicide attempt 32.21 15.32 13 69177 60905 63358927
Escherichia test positive 31.96 15.32 24 69166 2360 63417472
Memory impairment 31.90 15.32 40 69150 104218 63315614
Ankle brachial index decreased 31.87 15.32 9 69181 80 63419752
Pulse waveform abnormal 31.87 15.32 9 69181 80 63419752
Pseudomonal sepsis 31.81 15.32 24 69166 2377 63417455
Carotid intima-media thickness increased 31.48 15.32 9 69181 84 63419748
Hyperhidrosis 31.33 15.32 43 69147 107793 63312039
Growth hormone deficiency 31.24 15.32 10 69180 141 63419691
B-cell lymphoma 31.00 15.32 27 69163 3278 63416554
Heart rate decreased 30.99 15.32 6 69184 45554 63374278
White blood cell count abnormal 30.79 15.32 36 69154 6206 63413626
Pneumonia 30.77 15.32 682 68508 456085 62963747
Small intestinal obstruction 30.49 15.32 64 69126 18273 63401559
Dyspepsia 30.45 15.32 40 69150 102156 63317676
Premature delivery 30.36 15.32 87 69103 30194 63389638
Hypoaesthesia 30.17 15.32 89 69101 168304 63251528
Trichodysplasia spinulosa 30.07 15.32 14 69176 563 63419269
Lymphoproliferative disorder 29.79 15.32 26 69164 3164 63416668
Listeria sepsis 29.75 15.32 15 69175 720 63419112
Soft tissue infection 29.74 15.32 22 69168 2115 63417717
Flushing 29.66 15.32 23 69167 75064 63344768
Subdural hygroma 29.66 15.32 11 69179 246 63419586
C-reactive protein abnormal 29.45 15.32 7 69183 46089 63373743
Adenovirus infection 29.20 15.32 27 69163 3544 63416288
Encephalitis viral 29.10 15.32 20 69170 1712 63418120
Hepatosplenic candidiasis 29.09 15.32 11 69179 260 63419572
Leukaemia 29.08 15.32 29 69161 4179 63415653
Pneumonia cytomegaloviral 29.04 15.32 22 69168 2192 63417640
Medulloblastoma recurrent 28.75 15.32 8 69182 67 63419765
Paraparesis 28.74 15.32 22 69168 2226 63417606
Nasal congestion 28.74 15.32 18 69172 65642 63354190
Immune effector cell-associated neurotoxicity syndrome 28.49 15.32 22 69168 2255 63417577
Therapy non-responder 28.32 15.32 160 69030 75741 63344091
Weight decreased 28.31 15.32 181 69009 276617 63143215
Cerebellar stroke 28.22 15.32 11 69179 283 63419549
Rhabdomyosarcoma recurrent 28.09 15.32 7 69183 36 63419796
Seizure 27.85 15.32 243 68947 132391 63287441
Acute lymphocytic leukaemia refractory 27.76 15.32 8 69182 77 63419755
Tachycardia 27.75 15.32 222 68968 117934 63301898
Nephrolithiasis 27.58 15.32 6 69184 41978 63377854
Enterocolitis infectious 27.51 15.32 19 69171 1639 63418193
Gastric disorder 27.45 15.32 4 69186 37365 63382467
Intracardiac thrombus 27.39 15.32 22 69168 2388 63417444
COVID-19 27.38 15.32 214 68976 112889 63306943
Metastasis 27.37 15.32 31 69159 5166 63414666
Femur fracture 27.36 15.32 6 69184 41750 63378082
Lipase increased 27.25 15.32 43 69147 9857 63409975
Hyperammonaemia 27.20 15.32 31 69159 5201 63414631
Uterine enlargement 27.05 15.32 17 69173 1251 63418581
Primary immunodeficiency syndrome 27.04 15.32 7 69183 43 63419789
Capillary leak syndrome 26.97 15.32 21 69169 2179 63417653
Chronic hepatitis 26.96 15.32 15 69175 881 63418951
Blood pressure systolic increased 26.94 15.32 9 69181 47388 63372444
Epstein Barr virus positive mucocutaneous ulcer 26.94 15.32 12 69178 435 63419397
Hallucination 26.93 15.32 13 69177 54804 63365028
Atypical haemolytic uraemic syndrome 26.86 15.32 14 69176 721 63419111
Sciatica 26.85 15.32 3 69187 34321 63385511
Oesophageal candidiasis 26.84 15.32 32 69158 5631 63414201
Tracheo-oesophageal fistula 26.69 15.32 13 69177 579 63419253
Haemolytic uraemic syndrome 26.66 15.32 22 69168 2481 63417351
Recurrent cancer 26.63 15.32 20 69170 1967 63417865
Fluid retention 26.62 15.32 16 69174 59670 63360162
Erythema 26.60 15.32 100 69090 175651 63244181
Brain oedema 26.52 15.32 52 69138 14143 63405689
Rhinocerebral mucormycosis 26.48 15.32 12 69178 453 63419379
Infection 26.48 15.32 373 68817 228800 63191032
Streptococcus test positive 26.37 15.32 17 69173 1308 63418524
Geotrichum infection 26.26 15.32 12 69178 462 63419370
Cough 26.21 15.32 199 68991 292544 63127288
Ear infection 26.06 15.32 5 69185 38208 63381624
Hypertransaminasaemia 25.97 15.32 34 69156 6575 63413257
Pneumonitis 25.96 15.32 91 69099 35131 63384701
Alveolar soft part sarcoma 25.94 15.32 8 69182 99 63419733
SARS-CoV-2 test negative 25.67 15.32 12 69178 487 63419345
Leukaemia cutis 25.66 15.32 8 69182 103 63419729
Cytomegalovirus colitis 25.58 15.32 21 69169 2351 63417481
Tumour necrosis 25.43 15.32 14 69176 805 63419027
Oedema 25.38 15.32 42 69148 97580 63322252
Pleuroparenchymal fibroelastosis 25.31 15.32 8 69182 108 63419724
Respiratory arrest 25.17 15.32 3 69187 32642 63387190
Chronic kidney disease 25.15 15.32 9 69181 45389 63374443
Eczema 24.81 15.32 3 69187 32288 63387544
Lymphocytosis 24.74 15.32 22 69168 2745 63417087
Coagulopathy 24.58 15.32 63 69127 20481 63399351
Cataract 24.47 15.32 16 69174 57037 63362795
Central nervous system enteroviral infection 24.39 15.32 6 69184 29 63419803
Somnolence 24.32 15.32 106 69084 178579 63241253
Premature baby 24.20 15.32 63 69127 20672 63399160
Gastric stenosis 24.14 15.32 7 69183 69 63419763
Osteonecrosis 24.13 15.32 70 69120 24460 63395372
Anaesthesia 24.06 15.32 11 69179 424 63419408
Mediastinum neoplasm 24.05 15.32 7 69183 70 63419762
Acute respiratory distress syndrome 23.97 15.32 68 69122 23466 63396366
Graft versus host disease 23.84 15.32 33 69157 6730 63413102
Parainfluenzae virus infection 23.84 15.32 20 69170 2307 63417525
Stem cell transplant 23.67 15.32 18 69172 1804 63418028
Neurological decompensation 23.64 15.32 21 69169 2617 63417215
Cardiac disorder 23.55 15.32 13 69177 50803 63369029
Polyomavirus-associated nephropathy 23.44 15.32 18 69172 1830 63418002
Refractory cytopenia with multilineage dysplasia 23.39 15.32 8 69182 140 63419692
Coronavirus infection 23.35 15.32 26 69164 4252 63415580
Pericardial effusion 23.32 15.32 79 69111 29979 63389853
Radiation myelopathy 23.30 15.32 6 69184 36 63419796
Follicular lymphoma 23.29 15.32 9 69181 226 63419606
Metastases to lymph nodes 23.24 15.32 36 69154 8122 63411710
Visual impairment 23.22 15.32 35 69155 84411 63335421
Acquired gene mutation 23.06 15.32 14 69176 969 63418863
Abdominal neoplasm 23.05 15.32 10 69180 340 63419492
Partial seizures 22.88 15.32 30 69160 5812 63414020
Chronic hepatitis B 22.86 15.32 10 69180 347 63419485
Rash pruritic 22.77 15.32 19 69171 59780 63360052
Dry eye 22.72 15.32 8 69182 40753 63379079
Otitis media acute 22.71 15.32 14 69176 996 63418836
Unevaluable event 22.61 15.32 14 69176 51372 63368460
Pneumonia influenzal 22.56 15.32 17 69173 1680 63418152
Treatment failure 22.53 15.32 126 69064 198917 63220915
Jejunal stenosis 22.38 15.32 6 69184 43 63419789
Balance disorder 22.25 15.32 36 69154 84386 63335446
Pharyngeal inflammation 22.12 15.32 12 69178 670 63419162
Joint injury 22.11 15.32 3 69187 29569 63390263
Peripheral sensorimotor neuropathy 22.11 15.32 16 69174 1487 63418345
Nephroblastoma 21.96 15.32 5 69185 16 63419816
Product quality issue 21.85 15.32 6 69184 35859 63383973
Oophoritis 21.85 15.32 7 69183 99 63419733
Staphylococcus test positive 21.82 15.32 24 69166 3872 63415960
Peritonitis viral 21.81 15.32 6 69184 48 63419784
Throat irritation 21.66 15.32 7 69183 37640 63382192
Chromosomal deletion 21.65 15.32 7 69183 102 63419730
Cranial nerve disorder 21.51 15.32 11 69179 544 63419288
Brain injury 21.37 15.32 32 69158 7011 63412821
International normalised ratio increased 21.34 15.32 12 69178 46413 63373419
Rhinorrhoea 21.29 15.32 24 69166 65553 63354279
Angioedema 21.19 15.32 13 69177 47952 63371880
Fasciitis 21.02 15.32 11 69179 571 63419261
Mucosal infection 20.96 15.32 8 69182 194 63419638
Post-acute COVID-19 syndrome 20.94 15.32 10 69180 426 63419406
Blood immunoglobulin G decreased 20.90 15.32 19 69171 2439 63417393
Paranasal sinus mucosal hypertrophy 20.89 15.32 5 69185 21 63419811
Swollen tongue 20.87 15.32 6 69184 34794 63385038
Ocular lymphoma 20.80 15.32 6 69184 58 63419774
Flatulence 20.78 15.32 6 69184 34696 63385136
Amnesia 20.75 15.32 18 69172 55567 63364265
Emotional distress 20.68 15.32 5 69185 32544 63387288
Dry skin 20.54 15.32 19 69171 56868 63362964
Hyperglycaemic hyperosmolar nonketotic syndrome 20.45 15.32 13 69177 976 63418856
Papillary thyroid cancer 20.30 15.32 18 69172 2238 63417594
Epstein-Barr viraemia 20.20 15.32 13 69177 997 63418835
Primary mediastinal large B-cell lymphoma recurrent 20.18 15.32 6 69184 65 63419767
Vulvovaginitis 20.16 15.32 9 69181 328 63419504
Enterovirus infection 20.15 15.32 13 69177 1001 63418831
Blast cells present 20.03 15.32 10 69180 470 63419362
Limb discomfort 20.03 15.32 4 69186 29712 63390120
Inflammatory myofibroblastic tumour 20.02 15.32 5 69185 26 63419806
Subacute combined cord degeneration 19.96 15.32 8 69182 222 63419610
Haemoglobin abnormal 19.72 15.32 26 69164 5062 63414770
Ovarian injury 19.63 15.32 4 69186 6 63419826
Asthenia 19.62 15.32 297 68893 383307 63036525
Lymphocyte count decreased 19.62 15.32 75 69115 30182 63389650
T-cell lymphoma 19.48 15.32 11 69179 665 63419167
Obliterative bronchiolitis 19.42 15.32 17 69173 2078 63417754
Rhabdomyolysis 19.30 15.32 12 69178 43939 63375893
Cytogenetic abnormality 19.29 15.32 10 69180 509 63419323
Paraneoplastic pemphigus 19.19 15.32 6 69184 78 63419754
Renal replacement therapy 19.19 15.32 6 69184 78 63419754
IIIrd nerve paralysis 19.15 15.32 11 69179 687 63419145
Blood stem cell transplant failure 19.11 15.32 7 69183 151 63419681
Iris atrophy 18.98 15.32 6 69184 81 63419751
Retinoblastoma 18.98 15.32 6 69184 81 63419751
Thrombotic microangiopathy 18.90 15.32 38 69152 10523 63409309
Listeria encephalitis 18.89 15.32 8 69182 256 63419576
Disturbance in attention 18.84 15.32 9 69181 38180 63381652
Enteritis 18.80 15.32 33 69157 8253 63411579
Splenic marginal zone lymphoma 18.63 15.32 5 69185 36 63419796
Osteoporosis 18.60 15.32 21 69169 57317 63362515
Tooth disorder 18.54 15.32 4 69186 28153 63391679
Skin discolouration 18.54 15.32 9 69181 37819 63382013
Visceral leishmaniasis 18.53 15.32 10 69180 553 63419279
Escherichia sepsis 18.51 15.32 25 69165 4982 63414850
Localised infection 18.51 15.32 5 69185 30205 63389627
Monoplegia 18.42 15.32 20 69170 3181 63416651
Encephalitis 18.41 15.32 34 69156 8846 63410986
Splenic necrosis 18.40 15.32 5 69185 38 63419794
B-cell aplasia 18.34 15.32 6 69184 91 63419741
Genital infection 18.30 15.32 7 69183 171 63419661
Eye pain 18.27 15.32 7 69183 33847 63385985
Urethritis 18.22 15.32 8 69182 280 63419552
Flagellate dermatitis 18.18 15.32 7 69183 174 63419658
Bacillus test positive 18.17 15.32 5 69185 40 63419792
Amenorrhoea 18.14 15.32 36 69154 9878 63409954
Trichosporon infection 18.11 15.32 8 69182 284 63419548
Urinary tract infection bacterial 18.07 15.32 25 69165 5097 63414735
Generalised tonic-clonic seizure 18.06 15.32 71 69119 28945 63390887
Nephropathy toxic 18.04 15.32 35 69155 9444 63410388
Parvovirus infection 18.04 15.32 8 69182 287 63419545
Hypertension 18.03 15.32 206 68984 279097 63140735
Red blood cell sedimentation rate increased 17.98 15.32 13 69177 43969 63375863
Cardiac dysfunction 17.96 15.32 17 69173 2298 63417534
Paraesthesia 17.96 15.32 99 69091 156867 63262965
Hemiparesis 17.89 15.32 61 69129 23221 63396611
Stenotrophomonas infection 17.89 15.32 16 69174 2011 63417821
Head injury 17.82 15.32 4 69186 27392 63392440
Brain herniation 17.79 15.32 21 69169 3656 63416176
Gastrointestinal inflammation 17.75 15.32 26 69164 5586 63414246
Post lumbar puncture syndrome 17.68 15.32 10 69180 606 63419226
Aborted pregnancy 17.65 15.32 5 69185 45 63419787
Cancer in remission 17.55 15.32 5 69185 46 63419786
Enteral nutrition 17.55 15.32 5 69185 46 63419786
Delayed puberty 17.55 15.32 6 69184 105 63419727
Liver function test abnormal 17.50 15.32 16 69174 48165 63371667
Heart rate increased 17.46 15.32 49 69141 94189 63325643
Hereditary motor and sensory neuropathy 17.44 15.32 6 69184 107 63419725
Postictal state 17.42 15.32 12 69178 1031 63418801
Blood magnesium decreased 17.40 15.32 42 69148 13156 63406676
Peripheral T-cell lymphoma unspecified 17.30 15.32 7 69183 199 63419633
Vulvovaginal inflammation 17.28 15.32 11 69179 828 63419004
Sinusitis fungal 17.26 15.32 15 69175 1816 63418016
Skin ulcer 17.24 15.32 13 69177 43032 63376800
Encopresis 17.19 15.32 6 69184 112 63419720
Tessellated fundus 17.18 15.32 5 69185 50 63419782
B-cell type acute leukaemia 17.14 15.32 7 69183 204 63419628
Blood bilirubin increased 17.10 15.32 83 69107 37057 63382775
Campylobacter infection 17.08 15.32 12 69178 1064 63418768
Chemotherapeutic drug level above therapeutic 16.92 15.32 5 69185 53 63419779
Rectal fissure 16.90 15.32 10 69180 660 63419172
Beta 2 microglobulin decreased 16.87 15.32 4 69186 16 63419816
Subclavian vein thrombosis 16.84 15.32 15 69175 1875 63417957
Haematocolpos 16.83 15.32 5 69185 54 63419778
Swelling face 16.79 15.32 27 69163 63448 63356384
Mantle cell lymphoma 16.68 15.32 9 69181 497 63419335
Colitis ulcerative 16.59 15.32 4 69186 26087 63393745
Marginal zone lymphoma recurrent 16.49 15.32 4 69186 18 63419814
Enterocutaneous fistula 16.40 15.32 13 69177 1384 63418448
Urinary tract infection 16.39 15.32 197 68993 264487 63155345
Hepatic function abnormal 16.38 15.32 82 69108 37060 63382772
T-cell type acute leukaemia 16.36 15.32 5 69185 60 63419772
Cheyne-Stokes respiration 16.35 15.32 6 69184 130 63419702
Perirectal abscess 16.32 15.32 11 69179 912 63418920
Procalcitonin increased 16.28 15.32 12 69178 1147 63418685
B-lymphocyte count abnormal 16.28 15.32 5 69185 61 63419771
Osteosarcoma 16.23 15.32 6 69184 133 63419699
Psychogenic seizure 16.23 15.32 14 69176 1678 63418154
Enterococcus test positive 16.15 15.32 12 69178 1161 63418671
Malignant neoplasm of orbit 16.15 15.32 4 69186 20 63419812
Pyloric stenosis 16.14 15.32 8 69182 370 63419462
Duodenal stenosis 16.11 15.32 9 69181 533 63419299
Inguinal hernia 16.07 15.32 15 69175 1992 63417840
Impaired fasting glucose 16.02 15.32 7 69183 242 63419590
Gastrointestinal disorder 16.00 15.32 81 69109 131158 63288674
Acne 15.98 15.32 3 69187 23290 63396542
Hydrocephalus 15.96 15.32 24 69166 5276 63414556
Quadriparesis 15.93 15.32 15 69175 2014 63417818
Endocarditis 15.86 15.32 25 69165 5725 63414107
Encephalitis cytomegalovirus 15.82 15.32 9 69181 552 63419280
Neonatal respiratory distress 15.81 15.32 8 69182 387 63419445
Drug clearance decreased 15.71 15.32 13 69177 1471 63418361
Ocular hyperaemia 15.71 15.32 4 69186 25140 63394692
Hypercreatininaemia 15.67 15.32 9 69181 562 63419270
Pulmonary vascular disorder 15.66 15.32 8 69182 395 63419437
Granulocyte count decreased 15.56 15.32 12 69178 1228 63418604
Cardiac failure acute 15.56 15.32 33 69157 9490 63410342
Leukonychia 15.53 15.32 4 69186 24 63419808
Listeriosis 15.43 15.32 13 69177 1508 63418324
Areflexia 15.41 15.32 18 69172 3100 63416732
Blood disorder 15.41 15.32 27 69163 6744 63413088
Plasmodium falciparum infection 15.40 15.32 4 69186 25 63419807
Disseminated trichosporonosis 15.40 15.32 5 69185 74 63419758
Ventriculo-peritoneal shunt 15.39 15.32 3 69187 3 63419829
Antithrombin III deficiency 15.39 15.32 3 69187 3 63419829
Plasminogen decreased 15.39 15.32 3 69187 3 63419829
Low cardiac output syndrome 15.33 15.32 8 69182 413 63419419

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 4731.07 14.12 3441 88755 133408 34731327
Neutropenia 1399.99 14.12 1885 90311 154893 34709842
Disease progression 1105.65 14.12 1391 90805 106686 34758049
Myelosuppression 774.21 14.12 534 91662 18731 34846004
Diffuse large B-cell lymphoma recurrent 686.08 14.12 274 91922 2954 34861781
Product use in unapproved indication 673.05 14.12 1151 91045 116348 34748387
Mucosal inflammation 650.75 14.12 646 91550 37976 34826759
Haematotoxicity 602.61 14.12 334 91862 7860 34856875
Second primary malignancy 578.72 14.12 321 91875 7565 34857170
Hepatitis B reactivation 565.22 14.12 252 91944 3639 34861096
Off label use 522.15 14.12 2333 89863 417191 34447544
Febrile bone marrow aplasia 515.97 14.12 302 91894 7907 34856828
Hepatitis B 493.04 14.12 263 91933 5720 34859015
Pancytopenia 479.69 14.12 882 91314 94275 34770460
Bone marrow failure 455.45 14.12 469 91727 28784 34835951
Venoocclusive liver disease 415.40 14.12 260 91936 7706 34857029
Posterior reversible encephalopathy syndrome 411.74 14.12 281 91915 9673 34855062
Myelodysplastic syndrome 406.99 14.12 365 91831 18843 34845892
Acute myeloid leukaemia 398.66 14.12 353 91843 17917 34846818
Neoplasm progression 398.28 14.12 393 91803 22907 34841828
Tumour lysis syndrome 389.06 14.12 338 91858 16721 34848014
Hypofibrinogenaemia 347.47 14.12 140 92056 1546 34863189
Cytopenia 343.69 14.12 278 91918 12445 34852290
Therapy partial responder 322.74 14.12 239 91957 9377 34855358
Thrombocytopenia 302.28 14.12 1002 91194 155245 34709490
Pyrexia 284.87 14.12 1670 90526 331343 34533392
Fall 273.49 14.12 97 92099 202788 34661947
Product dose omission issue 264.99 14.12 12 92184 119699 34745036
Diffuse large B-cell lymphoma refractory 257.02 14.12 104 92092 1162 34863573
Progressive multifocal leukoencephalopathy 256.64 14.12 210 91986 9554 34855181
Sepsis 251.29 14.12 985 91211 165576 34699159
Neuropathy peripheral 245.02 14.12 621 91575 82642 34782093
Cytomegalovirus chorioretinitis 233.33 14.12 135 92061 3454 34861281
Neutropenic sepsis 232.94 14.12 231 91965 13536 34851199
Neutrophil count decreased 223.02 14.12 446 91750 50658 34814077
Hypogammaglobulinaemia 219.40 14.12 174 92022 7566 34857169
B-cell lymphoma recurrent 212.58 14.12 80 92116 724 34864011
Cardiotoxicity 211.43 14.12 150 92046 5498 34859237
Septic shock 208.41 14.12 533 91663 71301 34793434
Leukopenia 203.06 14.12 486 91710 62370 34802365
Arthralgia 197.56 14.12 101 92095 169940 34694795
Myocardial infarction 196.68 14.12 40 92156 121045 34743690
Dizziness 193.63 14.12 175 92021 218346 34646389
Fatigue 191.13 14.12 436 91760 370217 34494518
Death 188.94 14.12 489 91707 397560 34467175
Disease recurrence 188.40 14.12 257 91939 21233 34843502
Acquired gene mutation 184.82 14.12 84 92112 1271 34863464
Hyperbilirubinaemia 183.01 14.12 224 91972 16619 34848116
Hypertriglyceridaemia 181.77 14.12 162 92034 8286 34856449
Pneumocystis jirovecii pneumonia 180.84 14.12 241 91955 19469 34845266
Mantle cell lymphoma recurrent 180.48 14.12 70 92126 693 34864042
Cytokine release syndrome 178.89 14.12 259 91937 22618 34842117
Acute lymphocytic leukaemia recurrent 175.61 14.12 106 92090 2938 34861797
Dyspnoea 175.60 14.12 467 91729 376315 34488420
Lymphadenopathy 163.89 14.12 280 91916 28183 34836552
Rash 163.26 14.12 209 91987 222543 34642192
Aspergillus infection 156.42 14.12 177 92019 12077 34852658
Neoplasm recurrence 155.31 14.12 88 92108 2161 34862574
Candida infection 152.48 14.12 210 91986 17505 34847230
Muscle spasms 152.37 14.12 12 92184 74989 34789746
Pruritus 145.51 14.12 98 92098 141883 34722852
Rhabdomyolysis 143.98 14.12 9 92187 68154 34796581
Pain 142.86 14.12 199 91997 204476 34660259
Malaise 142.80 14.12 168 92028 185657 34679078
Insomnia 140.97 14.12 49 92147 103858 34760877
Joint swelling 139.38 14.12 4 92192 59886 34804849
Stomatitis 138.61 14.12 330 91866 42184 34822551
Bacteraemia 138.07 14.12 212 91984 19505 34845230
Malignant neoplasm progression 136.76 14.12 526 91670 87520 34777215
Polyneuropathy 136.42 14.12 182 92014 14714 34850021
Post transplant lymphoproliferative disorder 136.13 14.12 123 92073 6405 34858330
Anxiety 129.62 14.12 50 92146 99378 34765357
Diffuse large B-cell lymphoma 123.43 14.12 123 92073 7247 34857488
Peripheral swelling 122.75 14.12 26 92170 76515 34788220
Lymphoma 122.58 14.12 158 92038 12349 34852386
Neurotoxicity 122.40 14.12 191 92005 17819 34846916
Inappropriate schedule of product administration 121.03 14.12 12 92184 62284 34802451
Blood lactate dehydrogenase increased 120.45 14.12 217 91979 22773 34841962
Leukoencephalopathy 117.83 14.12 94 92102 4121 34860614
Venoocclusive disease 116.31 14.12 80 92116 2787 34861948
Depression 113.66 14.12 57 92139 97041 34767694
Overdose 113.47 14.12 49 92147 91010 34773725
Somnolence 112.07 14.12 78 92118 111038 34753697
Drug resistance 111.49 14.12 225 91971 25702 34839033
Hospitalisation 107.86 14.12 12 92184 56890 34807845
Lymphopenia 105.16 14.12 169 92027 16166 34848569
Epstein-Barr virus infection 103.91 14.12 114 92082 7514 34857221
Weight increased 103.90 14.12 58 92138 92975 34771760
White blood cell count decreased 100.77 14.12 508 91688 94937 34769798
Intentional product misuse 96.38 14.12 6 92190 45605 34819130
Myalgia 96.02 14.12 51 92145 84059 34780676
Fungal infection 96 14.12 160 92036 15775 34848960
Blood pressure increased 95.43 14.12 57 92139 88045 34776690
Coombs positive haemolytic anaemia 95.21 14.12 48 92148 924 34863811
Myelopathy 95.03 14.12 67 92129 2430 34862305
Suicidal ideation 92.87 14.12 3 92193 40385 34824350
Blood fibrinogen decreased 92.76 14.12 51 92145 1179 34863556
Acute lymphocytic leukaemia 92.12 14.12 71 92125 2958 34861777
Chest pain 91.62 14.12 120 92076 126642 34738093
Haemophagocytic lymphohistiocytosis 91.53 14.12 140 92056 12833 34851902
Confusional state 90.99 14.12 150 92046 144010 34720725
Neutropenic colitis 89.78 14.12 71 92125 3073 34861662
Coronary artery disease 89.53 14.12 11 92185 48294 34816441
Feeling abnormal 88.92 14.12 28 92168 63207 34801528
Cerebrovascular accident 87.54 14.12 58 92138 84753 34779982
Rheumatoid arthritis 87.36 14.12 3 92193 38235 34826500
Drug interaction 86.42 14.12 306 91890 225640 34639095
Herpes simplex 86.20 14.12 89 92107 5470 34859265
Cytomegalovirus infection 84.21 14.12 202 91994 25933 34838802
Nasopharyngitis 83.49 14.12 40 92156 69928 34794807
Lymphadenitis 83.24 14.12 57 92139 1971 34862764
Oedema peripheral 82.96 14.12 117 92079 119695 34745040
Sweat gland tumour 82.08 14.12 34 92162 405 34864330
Cerebral venous thrombosis 82.05 14.12 40 92156 714 34864021
Central nervous system lymphoma 78.56 14.12 43 92153 985 34863750
Pain in extremity 78.55 14.12 133 92063 126380 34738355
Tremor 78.04 14.12 62 92134 82525 34782210
Osteonecrosis 77.29 14.12 140 92056 14750 34849985
Cardiac failure congestive 76.84 14.12 64 92132 83206 34781529
Blood glucose increased 76.81 14.12 40 92156 66678 34798057
Chronic obstructive pulmonary disease 75.63 14.12 18 92178 48900 34815835
Hepatotoxicity 74.61 14.12 171 92025 21314 34843421
Hepatic failure 74.25 14.12 230 91966 34301 34830434
Aplasia 73.94 14.12 75 92121 4513 34860222
Hyperhidrosis 73.84 14.12 55 92141 75637 34789098
Diarrhoea 73.31 14.12 667 91529 389245 34475490
Musculoskeletal stiffness 72.52 14.12 17 92179 46663 34818072
Blood creatine phosphokinase increased 72.39 14.12 15 92181 44842 34819893
Minimal residual disease 72.21 14.12 31 92165 406 34864329
Asthma 71.50 14.12 13 92183 42643 34822092
Loss of personal independence in daily activities 71.20 14.12 4 92192 33175 34831560
Memory impairment 70.91 14.12 14 92182 43304 34821431
Anaemia 70.78 14.12 932 91264 232403 34632332
Bronchopulmonary aspergillosis 70.03 14.12 133 92063 14526 34850209
Cerebral venous sinus thrombosis 68.96 14.12 32 92164 509 34864226
Incorrect dose administered 68.67 14.12 12 92184 40503 34824232
Back pain 68.51 14.12 136 92060 121653 34743082
Pneumonia fungal 68.48 14.12 89 92107 7011 34857724
Injection site pain 67.33 14.12 11 92185 38994 34825741
Hallucination 66.90 14.12 26 92170 51472 34813263
Aggression 65.04 14.12 12 92184 38952 34825783
West Nile viral infection 64.82 14.12 34 92162 713 34864022
Psoriasis 64.68 14.12 12 92184 38800 34825935
Chest discomfort 63.80 14.12 32 92164 54498 34810237
Cytomegalovirus infection reactivation 63.73 14.12 73 92123 5045 34859690
Suicide attempt 63.28 14.12 13 92183 39103 34825632
Platelet count decreased 62.60 14.12 534 91662 119183 34745552
Colitis 62.23 14.12 230 91966 37520 34827215
Agranulocytosis 62.11 14.12 170 92026 23651 34841084
Gait disturbance 62.10 14.12 80 92116 85060 34779675
Plasma cell myeloma 62.04 14.12 17 92179 42020 34822715
Escherichia sepsis 61.82 14.12 69 92127 4635 34860100
Systemic mycosis 61.71 14.12 43 92153 1530 34863205
Malignant transformation 60.66 14.12 34 92162 817 34863918
Strongyloidiasis 60.33 14.12 53 92143 2658 34862077
Drug ineffective 60.19 14.12 1602 90594 455149 34409586
Headache 59.19 14.12 300 91896 200335 34664400
Ileus paralytic 59.13 14.12 76 92120 5921 34858814
Gastritis bacterial 58.27 14.12 22 92174 201 34864534
Multiple organ dysfunction syndrome 57.98 14.12 373 91823 76193 34788542
End stage renal disease 57.47 14.12 92 92104 8769 34855966
Lymphoma transformation 57.07 14.12 23 92173 254 34864481
Wheezing 57.01 14.12 19 92177 41383 34823352
Mucormycosis 56.55 14.12 74 92122 5868 34858867
Cardiomyopathy 56.40 14.12 132 92064 16676 34848059
Infection 55.94 14.12 421 91775 90494 34774241
Therapy non-responder 55.17 14.12 227 91969 38919 34825816
Sleep disorder 54.55 14.12 9 92187 31679 34833056
Klebsiella infection 54.54 14.12 88 92108 8443 34856292
Acute lymphocytic leukaemia refractory 54.33 14.12 18 92178 107 34864628
Escherichia infection 54.01 14.12 86 92110 8159 34856576
Enterovirus infection 53.45 14.12 33 92163 953 34863782
Arthropathy 52.73 14.12 5 92191 26902 34837833
Blood culture positive 52.57 14.12 64 92132 4719 34860016
Heart rate decreased 52.51 14.12 10 92186 31735 34833000
Haemolysis 52.44 14.12 84 92112 8010 34856725
Adenovirus infection 52.43 14.12 67 92129 5190 34859545
Loss of consciousness 52.12 14.12 86 92110 82581 34782154
Infection reactivation 51.98 14.12 38 92158 1460 34863275
Staphylococcal sepsis 51.65 14.12 93 92103 9751 34854984
Abdominal discomfort 51.57 14.12 49 92147 59786 34804949
Syncope 51.52 14.12 102 92094 91349 34773386
Drug hypersensitivity 51.50 14.12 83 92113 80446 34784289
B-cell lymphoma refractory 51.27 14.12 19 92177 164 34864571
Epstein-Barr virus associated lymphoma 51.21 14.12 28 92168 640 34864095
JC virus infection 48.80 14.12 43 92153 2165 34862570
Cystitis haemorrhagic 48.37 14.12 67 92129 5612 34859123
Adenoviral hepatitis 47.89 14.12 25 92171 519 34864216
Ill-defined disorder 47.51 14.12 110 92086 13799 34850936
Coagulopathy 47.44 14.12 137 92059 19652 34845083
Adverse drug reaction 46.95 14.12 10 92186 29332 34835403
Skin exfoliation 46.76 14.12 8 92188 27424 34837311
Antithrombin III decreased 46.48 14.12 21 92175 313 34864422
Bacterial sepsis 46.31 14.12 63 92133 5187 34859548
Asthenia 46.18 14.12 419 91777 244832 34619903
Blood pressure fluctuation 46.17 14.12 6 92190 25243 34839492
Blood pressure systolic increased 45.68 14.12 4 92192 22948 34841787
Wrong technique in product usage process 45.38 14.12 19 92177 35967 34828768
Atrial fibrillation 45.22 14.12 168 92028 122225 34742510
Multiple-drug resistance 44.91 14.12 62 92134 5177 34859558
Escherichia bacteraemia 44.63 14.12 49 92147 3231 34861504
Hepatosplenomegaly 44.55 14.12 55 92141 4114 34860621
Glioma 44.48 14.12 21 92175 348 34864387
Systemic candida 44.47 14.12 52 92144 3674 34861061
Intussusception 43.86 14.12 25 92171 621 34864114
Pseudomonas infection 43.48 14.12 99 92097 12283 34852452
Viral haemorrhagic cystitis 43.38 14.12 31 92165 1149 34863586
Cerebral toxoplasmosis 43.09 14.12 36 92160 1685 34863050
Balance disorder 43.02 14.12 27 92169 40627 34824108
Gastrointestinal toxicity 43 14.12 44 92152 2675 34862060
Mobility decreased 42.95 14.12 13 92183 30115 34834620
Epstein-Barr virus associated lymphoproliferative disorder 42.91 14.12 38 92158 1926 34862809
Erythema 42.66 14.12 108 92088 88672 34776063
Respiratory failure 42.21 14.12 455 91741 108117 34756618
Gastrooesophageal reflux disease 41.80 14.12 24 92172 37900 34826835
Retinal haemorrhage 41.79 14.12 59 92137 5030 34859705
Abdominal pain upper 41.77 14.12 78 92118 71412 34793323
Device related thrombosis 41.67 14.12 30 92166 1125 34863610
Contusion 41.55 14.12 22 92174 36342 34828393
Inappropriate antidiuretic hormone secretion 41.53 14.12 99 92097 12654 34852081
Cytogenetic abnormality 41.16 14.12 27 92169 868 34863867
Clostridium difficile infection 40.73 14.12 126 92070 18772 34845963
Parainfluenzae virus infection 39.77 14.12 43 92153 2787 34861948
Plasma cell myeloma refractory 39.62 14.12 23 92173 592 34864143
Intestinal perforation 39.38 14.12 79 92117 8981 34855754
Gastrosplenic fistula 39.34 14.12 12 92184 52 34864683
Bradycardia 39.21 14.12 88 92108 75330 34789405
Hypoglycaemia 39.15 14.12 52 92144 54588 34810147
Congenital cardiovascular anomaly 39.12 14.12 16 92180 184 34864551
Treatment noncompliance 38.50 14.12 13 92183 28087 34836648
Adverse event 38.37 14.12 3 92193 18874 34845861
Serotonin syndrome 38.28 14.12 4 92192 19929 34844806
Nephrolithiasis 38.27 14.12 16 92180 30317 34834418
Drug reaction with eosinophilia and systemic symptoms 37.67 14.12 20 92176 32992 34831743
Pneumonia aspiration 37.66 14.12 33 92163 41870 34822865
Injury 37.62 14.12 5 92191 20682 34844053
Cardio-respiratory arrest 37.21 14.12 55 92141 55218 34809517
Transformation to acute myeloid leukaemia 37.19 14.12 24 92172 750 34863985
Hepatocellular injury 37.16 14.12 136 92060 22075 34842660
Neoplasm 37.16 14.12 58 92138 5409 34859326
Bone marrow disorder 36.78 14.12 33 92163 1702 34863033
Pleural effusion 36.59 14.12 352 91844 81194 34783541
Encephalopathy 36.52 14.12 187 92009 35132 34829603
Juvenile melanoma benign 36.41 14.12 12 92184 70 34864665
Gene mutation 36.39 14.12 30 92166 1378 34863357
Subdural hygroma 36.39 14.12 18 92178 332 34864403
Weight decreased 36.37 14.12 294 91902 176007 34688728
Hot flush 36.36 14.12 3 92193 18063 34846672
Device related infection 36.29 14.12 114 92082 17123 34847612
Gallbladder oedema 36.19 14.12 16 92180 226 34864509
Bacterial infection 36.06 14.12 113 92083 16950 34847785
Neuroleptic malignant syndrome 36.04 14.12 3 92193 17931 34846804
Blood stem cell transplant failure 36.03 14.12 19 92177 403 34864332
COVID-19 pneumonia 35.53 14.12 112 92084 16855 34847880
Central nervous system neoplasm 35.45 14.12 12 92184 77 34864658
Unevaluable event 35.38 14.12 21 92175 32569 34832166
Road traffic accident 34.84 14.12 3 92193 17447 34847288
Leukaemia recurrent 34.79 14.12 31 92165 1584 34863151
Recurrent cancer 34.70 14.12 29 92167 1358 34863377
Atypical haemolytic uraemic syndrome 34.64 14.12 17 92179 308 34864427
Pulmonary vascular disorder 34.54 14.12 22 92174 672 34864063
Gastrointestinal haemorrhage 34.29 14.12 119 92077 88358 34776377
Coma 34.25 14.12 42 92154 45636 34819099
Nervous system disorder 34.20 14.12 100 92096 14443 34850292
Pneumonia viral 34.12 14.12 42 92154 3132 34861603
Klebsiella sepsis 34.11 14.12 34 92162 2003 34862732
Xanthogranuloma 33.99 14.12 11 92185 60 34864675
International normalised ratio increased 33.95 14.12 45 92151 47282 34817453
Varicella zoster virus infection 33.72 14.12 32 92164 1774 34862961
Aspiration bone marrow abnormal 33.67 14.12 13 92183 127 34864608
Flushing 33.66 14.12 22 92174 32398 34832337
Pseudomonal bacteraemia 33.60 14.12 29 92167 1420 34863315
Amnesia 33.53 14.12 14 92182 26549 34838186
Aplastic anaemia 33.36 14.12 77 92119 9639 34855096
Urticaria 33.07 14.12 72 92124 62305 34802430
Cardiac disorder 33.03 14.12 39 92157 43087 34821648
Acute monocytic leukaemia 32.95 14.12 17 92179 344 34864391
Hyperkalaemia 32.88 14.12 85 92111 69304 34795431
Lentigo 32.87 14.12 19 92177 485 34864250
Swelling 32.78 14.12 38 92158 42328 34822407
Cardiac arrest 32.32 14.12 137 92059 96022 34768713
Heart rate increased 32.29 14.12 45 92151 46298 34818437
Respiratory distress 32.23 14.12 182 92014 35483 34829252
Refractory cancer 32.22 14.12 13 92183 144 34864591
Ganglioneuroblastoma 32.06 14.12 9 92187 27 34864708
Bladder cancer 31.96 14.12 3 92193 16275 34848460
Influenza 31.92 14.12 51 92145 49615 34815120
Vision blurred 31.66 14.12 45 92151 45918 34818817
Enterocolitis infectious 31.59 14.12 30 92166 1665 34863070
Arthritis 31.57 14.12 22 92174 31324 34833411
Pulmonary arteriopathy 31.56 14.12 11 92185 78 34864657
Autoimmune lymphoproliferative syndrome 31.52 14.12 13 92183 153 34864582
Bone marrow infiltration 31.52 14.12 14 92182 200 34864535
Metastases to spleen 31.44 14.12 18 92178 451 34864284
Neurofibrosarcoma 31.35 14.12 9 92187 30 34864705
Abdominal neoplasm 31.27 14.12 17 92179 384 34864351
Product quality issue 31.26 14.12 4 92192 17031 34847704
Disorientation 31.22 14.12 25 92171 33163 34831572
Human rhinovirus test positive 31.21 14.12 14 92182 205 34864530
Transient ischaemic attack 31.11 14.12 17 92179 27596 34837139
Fluid retention 31.11 14.12 16 92180 26871 34837864
Erectile dysfunction 31.10 14.12 8 92188 20629 34844106
Injection site erythema 31.03 14.12 3 92193 15896 34848839
Lymphocytosis 30.82 14.12 36 92160 2541 34862194
Central nervous system leukaemia 30.61 14.12 15 92181 271 34864464
Dysgeusia 30.31 14.12 16 92180 26481 34838254
Ototoxicity 30.28 14.12 31 92165 1886 34862849
Staphylococcal bacteraemia 30.14 14.12 68 92128 8384 34856351
Eczema 30.08 14.12 6 92190 18430 34846305
Depressed mood 30.06 14.12 7 92189 19310 34845425
Primitive neuroectodermal tumour 29.97 14.12 10 92186 61 34864674
Medulloblastoma recurrent 29.83 14.12 10 92186 62 34864673
Azoospermia 29.76 14.12 17 92179 424 34864311
Palpitations 29.73 14.12 37 92159 39949 34824786
Peripheral motor neuropathy 29.70 14.12 30 92166 1796 34862939
Hepatosplenic candidiasis 29.65 14.12 14 92182 232 34864503
Ejection fraction decreased 29.32 14.12 114 92082 19040 34845695
Blood HIV RNA increased 29.30 14.12 25 92171 1205 34863530
Lower respiratory tract infection fungal 29.29 14.12 19 92177 599 34864136
Hepatic infection fungal 29.25 14.12 13 92183 186 34864549
Oesophageal stenosis 29.20 14.12 29 92167 1701 34863034
Respiratory arrest 29.16 14.12 19 92177 28024 34836711
Blood cholesterol increased 29.04 14.12 9 92187 20534 34844201
Agitation 29.00 14.12 68 92128 57331 34807404
Hepatomegaly 28.91 14.12 76 92120 10320 34854415
Encephalitis enteroviral 28.81 14.12 12 92184 145 34864590
Skin discolouration 28.72 14.12 6 92190 17839 34846896
Labelled drug-drug interaction medication error 28.68 14.12 3 92193 14936 34849799
Sleep apnoea syndrome 28.55 14.12 9 92187 20312 34844423
Liver function test abnormal 28.50 14.12 24 92172 31050 34833685
Neurological decompensation 28.32 14.12 37 92159 2929 34861806
Haemorrhage 28.31 14.12 58 92138 51312 34813423
Peripheral sensory neuropathy 28.26 14.12 58 92138 6702 34858033
Superior sagittal sinus thrombosis 28.22 14.12 14 92182 260 34864475
Pathogen resistance 28.11 14.12 71 92125 9411 34855324
Burning sensation 27.97 14.12 7 92189 18387 34846348
Chromosome analysis abnormal 27.96 14.12 12 92184 157 34864578
Haematochezia 27.86 14.12 50 92146 46484 34818251
Visual impairment 27.82 14.12 32 92164 35770 34828965
Central nervous system fungal infection 27.75 14.12 15 92181 335 34864400
Clostridium difficile colitis 27.74 14.12 98 92098 15632 34849103
Hereditary motor and sensory neuropathy 27.63 14.12 7 92189 12 34864723
Delayed puberty 27.61 14.12 13 92183 214 34864521
Peripheral sensorimotor neuropathy 27.59 14.12 27 92169 1555 34863180
Hepatic candidiasis 27.53 14.12 9 92187 51 34864684
Pulmonary sarcoidosis 27.46 14.12 18 92178 578 34864157
Pneumonitis 27.46 14.12 168 92028 33710 34831025
Toxicity to various agents 27.42 14.12 368 91828 199994 34664741
Psoriatic arthropathy 27.40 14.12 9 92187 19789 34844946
Molluscum contagiosum 27.38 14.12 14 92182 278 34864457
Cerebral thrombosis 27.21 14.12 22 92174 983 34863752
Pneumatosis intestinalis 27.20 14.12 42 92154 3881 34860854
Rectal haemorrhage 27.14 14.12 40 92156 40209 34824526
Small intestinal perforation 27.09 14.12 31 92165 2140 34862595
Influenza like illness 27.04 14.12 20 92176 27614 34837121
Transaminases increased 27.02 14.12 141 92055 26682 34838053
Gastrointestinal wall thickening 26.94 14.12 26 92170 1472 34863263
Pneumocystis jirovecii infection 26.83 14.12 28 92168 1742 34862993
Dry mouth 26.81 14.12 24 92172 30141 34834594
Philadelphia chromosome positive 26.74 14.12 15 92181 361 34864374
Diabetes mellitus 26.62 14.12 52 92144 46821 34817914
Musculoskeletal pain 26.58 14.12 27 92169 31936 34832799
Hypersensitivity 26.50 14.12 78 92118 60957 34803778
Cellulitis gangrenous 26.43 14.12 12 92184 181 34864554
Bone marrow necrosis 26.26 14.12 12 92184 184 34864551
Psychotic disorder 26.20 14.12 16 92180 24436 34840299
Deafness neurosensory 26.16 14.12 35 92161 2836 34861899
Disorder of orbit 26.14 14.12 10 92186 95 34864640
Epstein-Barr viraemia 25.94 14.12 24 92172 1288 34863447
Enterococcal infection 25.85 14.12 68 92128 9238 34855497
Vocal cord paralysis 25.85 14.12 21 92175 945 34863790
Rash pruritic 25.71 14.12 20 92176 26921 34837814
Rhinovirus infection 25.66 14.12 43 92153 4256 34860479
Rhabdomyosarcoma recurrent 25.60 14.12 10 92186 101 34864634
Herpes simplex encephalitis 25.37 14.12 14 92182 326 34864409
Benign prostatic hyperplasia 25.21 14.12 4 92192 14491 34850244
Prostate cancer 25.21 14.12 41 92155 39608 34825127
Acute promyelocytic leukaemia 25.11 14.12 16 92180 489 34864246
Disturbance in attention 25.10 14.12 19 92177 25926 34838809
Respiratory depression 25.06 14.12 6 92190 16239 34848496
Lung infiltration 25.04 14.12 83 92113 12822 34851913
Stevens-Johnson syndrome 24.89 14.12 9 92187 18630 34846105
Administration site extravasation 24.82 14.12 17 92179 588 34864147
Hallucination, visual 24.78 14.12 8 92188 17783 34846952
COVID-19 24.77 14.12 313 91883 77237 34787498
Haemoglobin abnormal 24.77 14.12 40 92156 3840 34860895
Immune effector cell-associated neurotoxicity syndrome 24.69 14.12 39 92157 3674 34861061
Left ventricular dysfunction 24.68 14.12 70 92126 9937 34854798
Nausea 24.52 14.12 696 91500 339212 34525523
Diverticulitis 24.52 14.12 11 92185 19993 34844742
Osteosarcoma 24.47 14.12 13 92183 280 34864455
Drug clearance decreased 24.46 14.12 27 92169 1791 34862944
Localised infection 24.33 14.12 8 92188 17579 34847156
Vertigo 24.32 14.12 19 92177 25517 34839218
Dyspepsia 24.28 14.12 37 92159 36695 34828040
Mass 24.28 14.12 60 92136 7845 34856890
Synovitis 24.20 14.12 4 92192 14062 34850673
Cerebral aspergillosis 24.16 14.12 24 92172 1408 34863327
Blood creatinine increased 24.15 14.12 149 92047 94827 34769908
Injection site reaction 24.06 14.12 3 92193 13030 34851705
Bacillus test positive 24.05 14.12 9 92187 80 34864655
Glioblastoma multiforme 23.99 14.12 18 92178 720 34864015
Delirium 23.96 14.12 50 92146 43941 34820794
Intestinal atresia 23.96 14.12 9 92187 81 34864654
Myocardial ischaemia 23.94 14.12 8 92188 17400 34847335
Blood bilirubin increased 23.90 14.12 178 92018 38118 34826617
B-cell lymphoma 23.89 14.12 42 92154 4321 34860414
Acute myelomonocytic leukaemia 23.85 14.12 10 92186 123 34864612
Cytomegalovirus hepatitis 23.85 14.12 15 92181 448 34864287
Body height below normal 23.85 14.12 12 92184 230 34864505
Candida pneumonia 23.79 14.12 15 92181 450 34864285
Frequent bowel movements 23.47 14.12 3 92193 12784 34851951
Angioedema 23.43 14.12 39 92157 37335 34827400
Loss of CAR T-cell persistence 23.39 14.12 7 92189 28 34864707
Adenocarcinoma gastric 23.31 14.12 22 92174 1211 34863524
Delusion 23.11 14.12 3 92193 12632 34852103
Pseudomonas test positive 23.00 14.12 21 92175 1108 34863627
Illness 22.93 14.12 4 92192 13525 34851210
Platelet transfusion 22.88 14.12 24 92172 1502 34863233
Myelitis transverse 22.83 14.12 21 92175 1119 34863616
Immunosuppression 22.80 14.12 51 92145 6253 34858482
Refractory anaemia with an excess of blasts 22.72 14.12 14 92182 403 34864332
Ameloblastoma 22.69 14.12 9 92187 95 34864640
Withdrawal syndrome 22.67 14.12 3 92193 12452 34852283
Basal cell naevus syndrome 22.65 14.12 7 92189 32 34864703
Candida sepsis 22.63 14.12 22 92174 1257 34863478
Orthostatic hypotension 22.59 14.12 21 92175 25898 34838837
Hypersomnia 22.56 14.12 3 92193 12404 34852331
Positron emission tomogram abnormal 22.44 14.12 10 92186 144 34864591
Genotoxicity 22.30 14.12 7 92189 34 34864701
Marginal zone lymphoma recurrent 22.30 14.12 7 92189 34 34864701
Blood glucose decreased 22.25 14.12 4 92192 13233 34851502
Head injury 22.24 14.12 10 92186 18150 34846585
Ureteric compression 22.20 14.12 12 92184 268 34864467
Disseminated intravascular coagulation 22.19 14.12 115 92081 21701 34843034
Melaena 22.10 14.12 37 92159 35343 34829392
Chloroma 22.10 14.12 15 92181 511 34864224
Medication error 21.94 14.12 21 92175 25544 34839191
Electrocardiogram QT prolonged 21.92 14.12 47 92149 40905 34823830
Enterovirus test positive 21.90 14.12 8 92188 66 34864669
Suspected product quality issue 21.90 14.12 10 92186 153 34864582
Dehydration 21.89 14.12 228 91968 129741 34734994
Metastases to bone marrow 21.79 14.12 15 92181 523 34864212
Restlessness 21.79 14.12 21 92175 25461 34839274
Plasmablastic lymphoma 21.74 14.12 13 92183 354 34864381
Acute hepatic failure 21.73 14.12 84 92112 13990 34850745
Hepatitis 21.61 14.12 122 92074 23782 34840953
Obesity 21.41 14.12 4 92192 12874 34851861
Hallucination, auditory 21.39 14.12 3 92193 11914 34852821
Candida endophthalmitis 21.37 14.12 9 92187 112 34864623
Swollen tongue 21.37 14.12 6 92190 14599 34850136
Dyspnoea exertional 21.28 14.12 52 92144 43227 34821508
Accidental exposure to product 21.24 14.12 4 92192 12798 34851937
Decreased appetite 21.19 14.12 310 91886 166082 34698653
Pneumonia necrotising 21.08 14.12 17 92179 757 34863978
Personality change due to a general medical condition 21.07 14.12 7 92189 42 34864693
Peripheral T-cell lymphoma unspecified 21.07 14.12 14 92182 460 34864275
Abnormal behaviour 20.86 14.12 21 92175 24948 34839787
Limb injury 20.84 14.12 3 92193 11686 34853049
Phlebitis infective 20.75 14.12 9 92187 121 34864614
Hyperleukocytosis 20.73 14.12 26 92170 1976 34862759
Meningitis tuberculous 20.71 14.12 16 92180 669 34864066
Sphingomonas paucimobilis infection 20.67 14.12 7 92189 45 34864690
Retinopathy proliferative 20.64 14.12 8 92188 79 34864656
Skin laceration 20.56 14.12 4 92192 12505 34852230
Hepatitis viral 20.48 14.12 15 92181 578 34864157
Diabetic ketoacidosis 20.46 14.12 11 92185 18021 34846714
Injection site swelling 20.46 14.12 3 92193 11524 34853211
Neck pain 20.41 14.12 22 92174 25327 34839408
Metastases to retroperitoneum 20.37 14.12 11 92185 245 34864490
Lung opacity 20.34 14.12 28 92168 2331 34862404
Granulocyte count decreased 20.31 14.12 17 92179 798 34863937
Helicobacter sepsis 20.25 14.12 6 92190 23 34864712
Thrombosis 20.12 14.12 67 92129 50391 34814344
Chronic lymphocytic leukaemia refractory 20.12 14.12 8 92188 85 34864650
Secondary immunodeficiency 20.12 14.12 13 92183 407 34864328
Urinary bladder rupture 20.04 14.12 8 92188 86 34864649
Neoplasm malignant 20.00 14.12 14 92182 19891 34844844
Meningitis cryptococcal 19.93 14.12 28 92168 2376 34862359
Oesophageal candidiasis 19.91 14.12 39 92157 4357 34860378
Leukaemia 19.84 14.12 40 92156 4563 34860172
Obstructive airways disorder 19.82 14.12 8 92188 15486 34849249
Taeniasis 19.80 14.12 7 92189 52 34864683
Cardiomegaly 19.71 14.12 8 92188 15430 34849305
Cerebral salt-wasting syndrome 19.69 14.12 7 92189 53 34864682
Morphoea 19.67 14.12 10 92186 196 34864539
Optic glioma 19.67 14.12 6 92190 26 34864709
Retroperitoneal lymphadenopathy 19.62 14.12 17 92179 837 34863898
Acute lung injury 19.59 14.12 22 92174 1488 34863247
Microgenia 19.58 14.12 5 92191 9 34864726
T-cell prolymphocytic leukaemia 19.57 14.12 7 92189 54 34864681
Splenic marginal zone lymphoma 19.49 14.12 6 92190 27 34864708
Stomatococcal infection 19.46 14.12 9 92187 142 34864593
B-lymphocyte count decreased 19.40 14.12 15 92181 628 34864107
Clostridium test positive 19.38 14.12 33 92163 3309 34861426
Stem cell transplant 19.37 14.12 26 92170 2113 34862622
Vagus nerve paralysis 19.24 14.12 5 92191 10 34864725
BK virus infection 19.18 14.12 45 92151 5693 34859042
Urinary retention 19.13 14.12 42 92154 36246 34828489
Periorbital infection 19.13 14.12 9 92187 148 34864587
Coronary artery occlusion 19.12 14.12 3 92193 10959 34853776
Neuroblastoma recurrent 19.07 14.12 9 92187 149 34864586
Pancreatitis 19.00 14.12 171 92025 38720 34826015
Condition aggravated 18.98 14.12 375 91821 191821 34672914
Chylothorax 18.86 14.12 16 92180 765 34863970
Diabetes mellitus inadequate control 18.85 14.12 6 92190 13458 34851277
Drug ineffective for unapproved indication 18.84 14.12 117 92079 23598 34841137
Focal nodular hyperplasia 18.80 14.12 9 92187 154 34864581
Disseminated cytomegaloviral infection 18.80 14.12 10 92186 216 34864519
Blood urea increased 18.74 14.12 32 92164 30332 34834403
Anal inflammation 18.70 14.12 20 92176 1280 34863455
Hepatic amoebiasis 18.63 14.12 7 92189 63 34864672
Sinusitis fungal 18.57 14.12 14 92182 564 34864171
Laboratory test abnormal 18.39 14.12 16 92180 20375 34844360
Cardiogenic shock 18.39 14.12 26 92170 26592 34838143
Therapy cessation 18.33 14.12 11 92185 16962 34847773
Ventricular tachycardia 18.32 14.12 26 92170 26553 34838182
Haematopoietic stem cell mobilisation 18.29 14.12 9 92187 164 34864571
Epidermal necrosis 18.28 14.12 13 92183 478 34864257
Disease susceptibility 18.16 14.12 7 92189 68 34864667
Catheter site thrombosis 18.16 14.12 8 92188 112 34864623
Metastases to muscle 18.04 14.12 10 92186 235 34864500
Graft versus host disease 17.92 14.12 65 92131 10504 34854231
Body temperature decreased 17.91 14.12 6 92190 13028 34851707
Therapy responder 17.81 14.12 9 92187 174 34864561
Blastic plasmacytoid dendritic cell neoplasia 17.81 14.12 7 92189 72 34864663
Lung neoplasm malignant 17.79 14.12 12 92184 17383 34847352
Sinus bradycardia 17.75 14.12 6 92190 12957 34851778
Sopor 17.73 14.12 5 92191 12131 34852604
Splenic candidiasis 17.72 14.12 7 92189 73 34864662
Pulmonary oedema 17.69 14.12 65 92131 47464 34817271
Leukaemia cutis 17.64 14.12 7 92189 74 34864661
Corynebacterium infection 17.60 14.12 14 92182 611 34864124
Proteinuria 17.59 14.12 14 92182 18628 34846107
Cardiac dysfunction 17.58 14.12 26 92170 2312 34862423
Extrapyramidal disorder 17.57 14.12 6 92190 12874 34851861
Gastric stenosis 17.56 14.12 7 92189 75 34864660
Skin cancer 17.55 14.12 3 92193 10294 34854441
Drug eruption 17.48 14.12 16 92180 19882 34844853
Traumatic lung injury 17.45 14.12 19 92177 1241 34863494
Astrocytoma 17.45 14.12 9 92187 182 34864553
Acute hepatitis B 17.41 14.12 9 92187 183 34864552
Enteritis 17.28 14.12 54 92142 8088 34856647
Splenic lesion 17.24 14.12 10 92186 257 34864478
Bronchitis 17.23 14.12 55 92141 41908 34822827
Cerebellar syndrome 17.16 14.12 26 92170 2362 34862373
Premature ageing 17.16 14.12 7 92189 80 34864655
Escherichia test positive 17.12 14.12 18 92178 1130 34863605
Chronic myeloid leukaemia 17.11 14.12 25 92171 2199 34862536
Hypothyroidism 16.99 14.12 18 92178 20884 34843851
Wound 16.96 14.12 9 92187 14855 34849880
Infusion site discolouration 16.92 14.12 8 92188 133 34864602
Intestinal pseudo-obstruction 16.91 14.12 22 92174 1734 34863001
Discomfort 16.91 14.12 15 92181 18923 34845812
Urethral obstruction 16.89 14.12 9 92187 195 34864540
Hepatitis E 16.86 14.12 24 92172 2062 34862673
Joint stiffness 16.80 14.12 4 92192 10869 34853866
5q minus syndrome 16.60 14.12 8 92188 139 34864596
Acute myocardial infarction 16.56 14.12 79 92117 53640 34811095
Skin toxicity 16.52 14.12 38 92158 4746 34859989
Pneumonia adenoviral 16.44 14.12 11 92185 366 34864369
Metapneumovirus infection 16.39 14.12 15 92181 794 34863941
Bacillus infection 16.31 14.12 10 92186 285 34864450
Gastrointestinal necrosis 16.24 14.12 31 92165 3398 34861337
Retroperitoneal mass 16.22 14.12 7 92189 93 34864642
Hydronephrosis 16.18 14.12 62 92134 10284 34854451
Renal tubular disorder 16.16 14.12 37 92159 4606 34860129
Blister 16.12 14.12 22 92174 22836 34841899
Viral load increased 16.06 14.12 26 92170 2501 34862234
Feeding intolerance 16.06 14.12 8 92188 150 34864585
Blindness cortical 16.02 14.12 11 92185 382 34864353
Muscle rigidity 16.00 14.12 4 92192 10514 34854221
Disseminated cryptococcosis 15.97 14.12 19 92177 1367 34863368
Coronary artery stenosis 15.96 14.12 3 92193 9613 34855122
Klebsiella bacteraemia 15.95 14.12 19 92177 1369 34863366
Pneumonia klebsiella 15.83 14.12 30 92166 3270 34861465
Respiratory tract infection fungal 15.75 14.12 14 92182 713 34864022
Fungaemia 15.75 14.12 26 92170 2542 34862193
Gait inability 15.65 14.12 19 92177 20739 34843996
Accidental overdose 15.65 14.12 18 92178 20122 34844613
Mixed anxiety and depressive disorder 15.64 14.12 7 92189 102 34864633
Chronic kidney disease 15.57 14.12 56 92140 41154 34823581
Panic attack 15.53 14.12 3 92193 9429 34855306
Transplant rejection 15.53 14.12 4 92192 10307 34854428
Cytomegalovirus viraemia 15.51 14.12 49 92147 7381 34857354
Pseudomonal sepsis 15.50 14.12 31 92165 3516 34861219
Peritoneal lesion 15.45 14.12 7 92189 105 34864630
B-cell type acute leukaemia 15.40 14.12 10 92186 316 34864419
Appendiceal abscess 15.39 14.12 7 92189 106 34864629
Feeling hot 15.39 14.12 17 92179 19355 34845380
Ganglioneuroma 15.39 14.12 4 92192 8 34864727
Superior vena cava syndrome 15.39 14.12 13 92183 618 34864117
Metastases to meninges 15.24 14.12 19 92177 1435 34863300
Congenital hepatobiliary anomaly 15.20 14.12 5 92191 29 34864706
Mastitis 15.11 14.12 8 92188 171 34864564
Carnitine deficiency 15.10 14.12 7 92189 111 34864624
Eye opacity 15.07 14.12 4 92192 9 34864726
Subclavian vein thrombosis 15.02 14.12 15 92181 886 34863849
Gastric disorder 15.00 14.12 7 92189 12434 34852301
Haemoptysis 15.00 14.12 45 92151 34961 34829774
Gastrointestinal protozoal infection 14.99 14.12 6 92190 65 34864670
Postural tremor 14.99 14.12 10 92186 331 34864404
Facial paresis 14.98 14.12 28 92168 3021 34861714
Vascular access complication 14.93 14.12 10 92186 333 34864402
Multiple lentigines syndrome 14.91 14.12 5 92191 31 34864704
Renal salt-wasting syndrome 14.88 14.12 10 92186 335 34864400
Blood urine present 14.86 14.12 5 92191 10829 34853906
Bladder spasm 14.86 14.12 15 92181 897 34863838
Mucosal toxicity 14.83 14.12 9 92187 252 34864483
Lymphocytic leukaemia 14.82 14.12 8 92188 178 34864557
Hypouricaemia 14.79 14.12 9 92187 253 34864482
Hypoaesthesia 14.79 14.12 98 92098 61346 34803389
Clostridium bacteraemia 14.78 14.12 8 92188 179 34864556
Infection in an immunocompromised host 14.73 14.12 13 92183 656 34864079
Enterobacter bacteraemia 14.64 14.12 11 92185 441 34864294
Rales 14.57 14.12 4 92192 9879 34854856
Streptococcal infection 14.55 14.12 37 92159 4924 34859811
Product administration error 14.53 14.12 13 92183 16331 34848404
Hepatitis B DNA increased 14.52 14.12 12 92184 553 34864182
Lewis-Sumner syndrome 14.52 14.12 5 92191 34 34864701
Acral lentiginous melanoma 14.52 14.12 5 92191 34 34864701
Paternal exposure timing unspecified 14.52 14.12 5 92191 34 34864701
Neuroborreliosis 14.52 14.12 5 92191 34 34864701
Selective mutism 14.52 14.12 6 92190 71 34864664
Ocular hyperaemia 14.51 14.12 6 92190 11446 34853289
T-cell type acute leukaemia 14.51 14.12 7 92189 122 34864613
Exposure during pregnancy 14.38 14.12 3 92193 8931 34855804
Troponin increased 14.38 14.12 6 92190 11383 34853352
Irritability 14.36 14.12 27 92169 24663 34840072
Epidural haemorrhage 14.30 14.12 6 92190 74 34864661
Diffuse alopecia 14.30 14.12 6 92190 74 34864661
Congenital herpes simplex infection 14.28 14.12 5 92191 36 34864699
Pneumaturia 14.28 14.12 5 92191 36 34864699
Peripheral T-cell lymphoma unspecified refractory 14.25 14.12 4 92192 12 34864723
Metapneumovirus bronchiolitis 14.25 14.12 4 92192 12 34864723
Spindle cell sarcoma 14.21 14.12 7 92189 128 34864607
Food protein-induced enterocolitis syndrome 14.16 14.12 5 92191 37 34864698
Speech disorder 14.15 14.12 29 92167 25657 34839078
Hypertension 14.13 14.12 264 91932 136179 34728556
Aeromonas infection 14.13 14.12 9 92187 275 34864460

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 9056.15 13.08 5463 139673 225536 79373716
Neutropenia 2735.95 13.08 2974 142162 284736 79314516
Disease progression 1516.16 13.08 1770 143366 182592 79416660
Haematotoxicity 1327.61 13.08 621 144515 14898 79584354
Product use in unapproved indication 1245.76 13.08 1879 143257 248480 79350772
Pancytopenia 1218.97 13.08 1504 143632 164241 79435011
Mucosal inflammation 1141.79 13.08 1009 144127 74571 79524681
Myelosuppression 1136.77 13.08 779 144357 39517 79559735
Second primary malignancy 1065.40 13.08 521 144615 13829 79585423
Bone marrow failure 1048.71 13.08 815 144321 50292 79548960
Diffuse large B-cell lymphoma recurrent 1045.84 13.08 363 144773 3844 79595408
Febrile bone marrow aplasia 1024.76 13.08 492 144644 12528 79586724
Hepatitis B reactivation 938.43 13.08 370 144766 5738 79593514
Myelodysplastic syndrome 883.54 13.08 598 144538 29703 79569549
Acute myeloid leukaemia 880.29 13.08 601 144535 30284 79568968
Off label use 839.80 13.08 3561 141575 903654 78695598
Posterior reversible encephalopathy syndrome 817.56 13.08 540 144596 25741 79573511
Thrombocytopenia 806.65 13.08 1602 143534 263657 79335595
Tumour lysis syndrome 769.31 13.08 502 144634 23437 79575815
Sepsis 716.54 13.08 1540 143596 267888 79331364
Hepatitis B 671.28 13.08 320 144816 8012 79591240
Neuropathy peripheral 611.63 13.08 996 144140 140309 79458943
Venoocclusive liver disease 607.89 13.08 335 144801 11436 79587816
Septic shock 601.27 13.08 916 144220 121885 79477367
Neoplasm progression 579.07 13.08 585 144551 51097 79548155
Pain 525.89 13.08 316 144820 703486 78895766
Pyrexia 523.50 13.08 2528 142608 676181 78923071
Cytopenia 502.42 13.08 363 144773 20020 79579232
Therapy partial responder 494.34 13.08 338 144798 17059 79582193
Fall 487.19 13.08 142 144994 487487 79111765
Neutropenic sepsis 472.83 13.08 393 144743 26671 79572581
Arthralgia 455.27 13.08 237 144899 571566 79027686
Joint swelling 447.50 13.08 18 145118 288628 79310624
Leukopenia 418.10 13.08 756 144380 115757 79483495
Hypofibrinogenaemia 407.65 13.08 149 144987 1853 79597399
Malignant neoplasm progression 388.29 13.08 801 144335 135189 79464063
Acute lymphocytic leukaemia recurrent 376.16 13.08 180 144956 4544 79594708
Fatigue 375.02 13.08 703 144433 929024 78670228
Product dose omission issue 365.77 13.08 21 145115 247516 79351736
Cytomegalovirus chorioretinitis 365.04 13.08 185 144951 5305 79593947
Disease recurrence 363.99 13.08 425 144711 43684 79555568
Pneumocystis jirovecii pneumonia 362.28 13.08 367 144769 32141 79567111
Rheumatoid arthritis 357.70 13.08 4 145132 208466 79390786
Progressive multifocal leukoencephalopathy 357.47 13.08 298 144838 20302 79578950
Pruritus 355.44 13.08 137 144999 394511 79204741
Neutrophil count decreased 348.98 13.08 619 144517 93340 79505912
Dizziness 346.53 13.08 271 144865 526170 79073082
Neurotoxicity 345.85 13.08 358 144778 32160 79567092
Multiple organ dysfunction syndrome 334.70 13.08 701 144435 119545 79479707
Cardiotoxicity 334.06 13.08 232 144904 12007 79587245
Peripheral swelling 329.48 13.08 49 145087 269568 79329684
Diffuse large B-cell lymphoma refractory 326.71 13.08 116 145020 1319 79597933
Hypogammaglobulinaemia 308.59 13.08 226 144910 12725 79586527
Aspergillus infection 307.48 13.08 265 144871 18896 79580356
Nasopharyngitis 303.71 13.08 49 145087 253832 79345420
Ototoxicity 301.67 13.08 138 144998 3136 79596116
Interstitial lung disease 298.99 13.08 644 144492 111956 79487296
Dyspnoea 296.69 13.08 706 144430 856319 78742933
Rash 296.34 13.08 371 144765 577987 79021265
B-cell lymphoma recurrent 294.49 13.08 98 145038 902 79598350
Hypertriglyceridaemia 293.84 13.08 218 144918 12522 79586730
Arthropathy 288.88 13.08 7 145129 177104 79422148
Secondary immunodeficiency 281.39 13.08 131 145005 3103 79596149
Malaise 280.52 13.08 287 144849 489582 79109670
Haemophagocytic lymphohistiocytosis 277.70 13.08 265 144871 21572 79577680
Bacteraemia 275.36 13.08 319 144817 32505 79566747
Abdominal discomfort 275.14 13.08 60 145076 250667 79348585
Cytokine release syndrome 267.68 13.08 329 144807 35669 79563583
Weight increased 267.24 13.08 86 145050 277300 79321952
Insomnia 260.39 13.08 63 145073 245107 79354145
Drug resistance 256.30 13.08 349 144787 41864 79557388
Aplasia 256.08 13.08 166 144970 7654 79591598
Synovitis 253.68 13.08 4 145132 150730 79448522
Headache 251.97 13.08 507 144629 653265 78945987
Musculoskeletal stiffness 243.47 13.08 20 145116 174988 79424264
Swelling 241.56 13.08 50 145086 216661 79382591
Drug abuse 236.63 13.08 15 145121 162676 79436576
Drug hypersensitivity 234.33 13.08 126 145010 298790 79300462
Platelet count decreased 233.37 13.08 832 144304 193832 79405420
Epstein-Barr virus infection 228.51 13.08 198 144938 14218 79585034
Anxiety 227.35 13.08 84 145052 248428 79350824
Hyperbilirubinaemia 225.57 13.08 250 144886 24268 79574984
Neutropenic colitis 224.25 13.08 136 145000 5571 79593681
Neoplasm recurrence 223.26 13.08 122 145014 4092 79595160
Polyneuropathy 221.75 13.08 246 144890 23905 79575347
Bronchopulmonary aspergillosis 220.23 13.08 236 144900 22058 79577194
Diffuse large B-cell lymphoma 219.63 13.08 180 144956 11969 79587283
Leukoencephalopathy 215.68 13.08 150 144986 7779 79591473
Acquired gene mutation 214.83 13.08 97 145039 2136 79597116
Anaemia 212.88 13.08 1462 143674 443553 79155699
Lymphadenopathy 212.22 13.08 362 144774 52885 79546367
Blood lactate dehydrogenase increased 211.27 13.08 306 144830 38864 79560388
Cardiomyopathy 198.00 13.08 253 144883 28521 79570731
Blood pressure increased 197.46 13.08 69 145067 211291 79387961
Post transplant lymphoproliferative disorder 197.14 13.08 165 144971 11299 79587953
Candida infection 193.79 13.08 290 144846 37924 79561328
Venoocclusive disease 192.72 13.08 114 145022 4459 79594793
Bacterial infection 190.46 13.08 259 144877 31021 79568231
Lymphopenia 187.55 13.08 254 144882 30303 79568949
Feeling abnormal 187.47 13.08 32 145104 159167 79440085
Pain in extremity 187.29 13.08 233 144903 364305 79234947
Muscle spasms 187.24 13.08 44 145092 174686 79424566
Lymphoma 185.22 13.08 192 144944 17268 79581984
Myelopathy 183.57 13.08 111 145025 4522 79594730
Inappropriate schedule of product administration 181.15 13.08 17 145119 133611 79465641
Injection site pain 180.12 13.08 15 145121 129823 79469429
Contusion 177.19 13.08 29 145107 148747 79450505
White blood cell count decreased 176.79 13.08 745 144391 187543 79411709
Acute lymphocytic leukaemia 176.41 13.08 111 145025 4858 79594394
Asthma 175.87 13.08 20 145116 135075 79464177
Ileus paralytic 174.89 13.08 143 144993 9477 79589775
Overdose 174.02 13.08 59 145077 184147 79415105
Pneumatosis intestinalis 173.96 13.08 121 145015 6276 79592976
Mantle cell lymphoma recurrent 173.03 13.08 58 145078 547 79598705
Wound 168.07 13.08 11 145125 116168 79483084
Cytomegalovirus infection 167.40 13.08 288 144848 42356 79556896
Parainfluenzae virus infection 160.45 13.08 110 145026 5572 79593680
Hypersensitivity 157.54 13.08 147 144989 262092 79337160
Myocardial infarction 155.74 13.08 70 145066 184059 79415193
Discomfort 155.27 13.08 22 145114 125595 79473657
Agranulocytosis 154.80 13.08 287 144849 44743 79554509
Clostridium difficile colitis 152.40 13.08 237 144899 32046 79567206
Contraindicated product administered 149.59 13.08 50 145086 157488 79441764
Respiratory failure 149.46 13.08 689 144447 180222 79419030
Mucormycosis 147.92 13.08 123 145013 8346 79590906
Intentional product misuse 147.12 13.08 6 145130 95159 79504093
Staphylococcal bacteraemia 143.57 13.08 142 144994 12076 79587176
Hepatic failure 143.20 13.08 333 144803 60879 79538373
Glossodynia 143.16 13.08 12 145124 103325 79495927
Herpes simplex 142.02 13.08 141 144995 12046 79587206
Diarrhoea 138.96 13.08 986 144150 879503 78719749
Drug intolerance 138.54 13.08 166 144970 263953 79335299
Loss of personal independence in daily activities 136.53 13.08 14 145122 102566 79496686
Chest pain 135.15 13.08 190 144946 282114 79317138
Systemic candida 133.21 13.08 105 145031 6601 79592651
Urticaria 132.45 13.08 87 145049 185114 79414138
Stomatitis 131.77 13.08 573 144563 146184 79453068
Abdominal pain upper 131.44 13.08 128 145008 223691 79375561
Stress 130.33 13.08 3 145133 79609 79519643
Arthritis 129.00 13.08 26 145110 114854 79484398
Klebsiella infection 128.85 13.08 151 144985 15569 79583683
Wheezing 127.72 13.08 28 145108 116636 79482616
Rhinovirus infection 127.60 13.08 110 145026 7843 79591409
Blood culture positive 126.03 13.08 112 145024 8317 79590935
Rhabdomyolysis 123.02 13.08 20 145116 103111 79496141
Mobility decreased 122.77 13.08 35 145101 122140 79477112
Depression 122.71 13.08 128 145008 216662 79382590
Psoriasis 122.47 13.08 11 145125 89576 79509676
Colitis 122.10 13.08 351 144785 72956 79526296
Lymphadenitis 121.80 13.08 86 145050 4569 79594683
Escherichia bacteraemia 120.24 13.08 98 145038 6464 79592788
Osteoarthritis 118.61 13.08 11 145125 87298 79511954
Nausea 118.23 13.08 1144 143992 956052 78643200
Psoriatic arthropathy 117.04 13.08 6 145130 77993 79521259
Ejection fraction decreased 115.87 13.08 218 144918 34359 79564893
Bronchitis 114.70 13.08 47 145089 130597 79468655
Back pain 113.35 13.08 240 144896 303940 79295312
Oedema peripheral 112.76 13.08 178 144958 252110 79347142
Myalgia 112.70 13.08 103 145033 185538 79413714
Blood fibrinogen decreased 112.39 13.08 60 145076 1919 79597333
Cystitis haemorrhagic 110.37 13.08 108 145028 9064 79590188
Blister 109.83 13.08 40 145096 119436 79479816
Sinusitis 108.88 13.08 117 145019 195384 79403868
Gene mutation 108.09 13.08 65 145071 2621 79596631
Pneumonia fungal 107.78 13.08 117 145019 11093 79588159
Injury 107.34 13.08 9 145127 77487 79521765
Peripheral sensory neuropathy 106.50 13.08 125 145011 12908 79586344
Hospitalisation 106.49 13.08 21 145115 94215 79505037
Pseudomonal sepsis 106.44 13.08 89 145047 6085 79593167
Confusional state 106.31 13.08 266 144870 317731 79281521
Injection site erythema 105.83 13.08 10 145126 78187 79521065
Coombs positive haemolytic anaemia 105.27 13.08 48 145088 1082 79598170
Human herpesvirus 6 infection 104.34 13.08 83 145053 5287 79593965
Central nervous system lymphoma 104.22 13.08 60 145076 2229 79597023
Drug interaction 104.21 13.08 396 144740 414787 79184465
Mycobacterium chelonae infection 102.90 13.08 61 145075 2395 79596857
Hepatotoxicity 102.66 13.08 263 144873 51089 79548163
Enterococcal infection 101.96 13.08 134 145002 15526 79583726
Epstein-Barr virus associated lymphoproliferative disorder 101.21 13.08 69 145067 3463 79595789
Somnolence 99.95 13.08 176 144960 238805 79360447
Alopecia 99.85 13.08 167 144969 231188 79368064
Irritable bowel syndrome 99.43 13.08 3 145133 62238 79537014
Peripheral motor neuropathy 99.39 13.08 67 145069 3300 79595952
Cerebral venous sinus thrombosis 98.87 13.08 58 145078 2233 79597019
Chest discomfort 98.48 13.08 65 145071 137979 79461273
Blood pressure fluctuation 98.17 13.08 6 145130 67139 79532113
Blood cholesterol increased 98.15 13.08 17 145119 83703 79515549
Disseminated intravascular coagulation 97.34 13.08 207 144929 35635 79563617
Cerebral venous thrombosis 96.48 13.08 61 145075 2692 79596560
Therapeutic product effect decreased 95.85 13.08 94 145042 163769 79435483
Suicidal ideation 95.20 13.08 13 145123 76327 79522925
Cytomegalovirus infection reactivation 94.52 13.08 97 145039 8619 79590633
Aplastic anaemia 93.81 13.08 138 144998 17767 79581485
Pleural effusion 93.66 13.08 516 144620 144746 79454506
Duodenal ulcer perforation 93.63 13.08 7 145129 66204 79533048
Human bocavirus infection 93.37 13.08 39 145097 706 79598546
Hyperhidrosis 93.20 13.08 83 145053 151409 79447843
Glioma 93.15 13.08 37 145099 585 79598667
Malignant transformation 92.70 13.08 45 145091 1173 79598079
Superior sagittal sinus thrombosis 92.30 13.08 43 145093 1020 79598232
Fungal infection 92.08 13.08 222 144914 41526 79557726
Gastrosplenic fistula 91.56 13.08 25 145111 106 79599146
Leukaemia recurrent 91.10 13.08 59 145077 2715 79596537
Intestinal perforation 90.85 13.08 134 145002 17292 79581960
JC virus infection 90.81 13.08 67 145069 3814 79595438
COVID-19 pneumonia 90.66 13.08 177 144959 28672 79570580
Bacterial sepsis 90.29 13.08 92 145044 8106 79591146
Cerebrovascular accident 89.77 13.08 90 145046 155202 79444050
Enterobacter infection 89.69 13.08 71 145065 4491 79594761
Osteonecrosis 89.59 13.08 184 144952 30911 79568341
Palpitations 88.46 13.08 61 145075 126549 79472703
Lymphoma transformation 87.93 13.08 30 145106 300 79598952
Folliculitis 87.28 13.08 3 145133 55377 79543875
Pseudomonas infection 87.09 13.08 145 144991 20758 79578494
Incorrect dose administered 86.74 13.08 17 145119 76613 79522639
Inappropriate antidiuretic hormone secretion 85.81 13.08 164 144972 26149 79573103
West Nile viral infection 85.35 13.08 40 145096 962 79598290
Sleep disorder 85.23 13.08 25 145111 85652 79513600
Staphylococcal sepsis 85.22 13.08 119 145017 14607 79584645
Adenovirus infection 84.44 13.08 90 145046 8357 79590895
Blood glucose increased 82.19 13.08 54 145082 114921 79484331
Blood pressure systolic increased 82.14 13.08 12 145124 66974 79532278
Strongyloidiasis 81.69 13.08 63 145073 3835 79595417
Remission not achieved 81.64 13.08 30 145106 379 79598873
Cytomegalovirus viraemia 80.84 13.08 108 145028 12713 79586539
Smooth muscle cell neoplasm 80.70 13.08 38 145098 924 79598328
Injection site reaction 79.78 13.08 5 145131 54780 79544472
Encephalopathy 79.72 13.08 287 144849 67110 79532142
Antithrombin III decreased 79.29 13.08 31 145105 469 79598783
Suicide attempt 79.26 13.08 26 145110 82906 79516346
Epstein-Barr virus associated lymphoma 79.19 13.08 39 145097 1050 79598202
Memory impairment 79.17 13.08 53 145083 111681 79487571
Heart rate decreased 78.75 13.08 16 145120 70300 79528952
Oesophageal candidiasis 77.98 13.08 90 145046 9128 79590124
Impaired healing 77.80 13.08 31 145105 87624 79511628
Sweat gland tumour 77.65 13.08 31 145105 497 79598755
Vocal cord paralysis 77.62 13.08 52 145084 2535 79596717
Hepatocellular injury 77.42 13.08 226 144910 47367 79551885
Device related infection 77.39 13.08 184 144952 34110 79565142
Ascites 77.16 13.08 307 144829 75255 79523997
Dry skin 77.14 13.08 15 145121 67980 79531272
Erythema 76.76 13.08 184 144952 223106 79376146
Gait disturbance 76.19 13.08 165 144971 207341 79391911
Enterovirus infection 75.47 13.08 46 145090 1901 79597351
Loss of consciousness 75.47 13.08 118 145018 167825 79431427
Escherichia infection 75.09 13.08 125 145011 17892 79581360
Musculoskeletal pain 74.63 13.08 47 145089 102307 79496945
Adverse drug reaction 74.58 13.08 15 145121 66377 79532875
Left ventricular dysfunction 73.67 13.08 129 145007 19232 79580020
Escherichia sepsis 73.54 13.08 84 145052 8424 79590828
Hepatomegaly 73.44 13.08 127 145009 18747 79580505
Neck pain 73.22 13.08 23 145113 75394 79523858
Human rhinovirus test positive 72.92 13.08 29 145107 460 79598792
Cystitis bacterial 72.00 13.08 32 145104 678 79598574
Enterococcal bacteraemia 71.86 13.08 53 145083 3015 79596237
Gastrooesophageal reflux disease 71.79 13.08 51 145085 104195 79495057
Hot flush 71.71 13.08 8 145128 54869 79544383
Infection reactivation 71.64 13.08 50 145086 2607 79596645
Dry mouth 70.51 13.08 36 145100 87983 79511269
Pneumonia 70.17 13.08 1633 143503 658613 78940639
Philadelphia chromosome positive 69.65 13.08 31 145105 659 79598593
Respiratory distress 69.48 13.08 249 144887 58090 79541162
Death 69.28 13.08 678 144458 565836 79033416
Cytogenetic abnormality 69.26 13.08 36 145100 1089 79598163
Coronary artery disease 69.10 13.08 17 145119 65457 79533795
Hallucination 68.79 13.08 35 145101 85710 79513542
Product prescribing error 68.67 13.08 3 145133 44810 79554442
Fungaemia 68.63 13.08 61 145075 4530 79594722
Blood creatine phosphokinase increased 68.13 13.08 18 145118 66072 79533180
Hepatic enzyme increased 68.04 13.08 144 144992 182466 79416786
Influenza like illness 67.62 13.08 23 145113 71684 79527568
Refractory anaemia with an excess of blasts 67.53 13.08 33 145103 873 79598379
Pseudomonas test positive 67.32 13.08 42 145094 1810 79597442
Deafness 67.23 13.08 130 145006 20907 79578345
End stage renal disease 66.65 13.08 96 145040 12124 79587128
Varicella zoster virus infection 66.37 13.08 59 145077 4382 79594870
Helicobacter infection 66.36 13.08 22 145114 69682 79529570
Illness 65.53 13.08 5 145131 46506 79552746
Condition aggravated 65.42 13.08 590 144546 500534 79098718
Fusarium infection 65.22 13.08 41 145095 1791 79597461
Pseudomonal bacteraemia 65.00 13.08 50 145086 3032 79596220
Myeloid leukaemia 64.73 13.08 30 145106 703 79598549
Burning sensation 64.31 13.08 14 145122 58618 79540634
Injection site pruritus 64.24 13.08 3 145133 42280 79556972
Hepatitis E 64.19 13.08 49 145087 2937 79596315
Heart rate increased 64.18 13.08 75 145061 120649 79478603
Infection 63.90 13.08 697 144439 241015 79358237
Injection site swelling 63.84 13.08 6 145130 47126 79552126
Road traffic accident 63.53 13.08 4 145132 43660 79555592
Glioblastoma multiforme 63.53 13.08 35 145101 1193 79598059
C-reactive protein abnormal 63.33 13.08 7 145129 48360 79550892
Enterovirus test positive 63.21 13.08 23 145113 282 79598970
Serotonin syndrome 62.99 13.08 5 145131 45022 79554230
Dyspepsia 62.79 13.08 63 145073 108624 79490628
Thymus hypoplasia 62.39 13.08 32 145104 941 79598311
Acute promyelocytic leukaemia 62.39 13.08 37 145099 1454 79597798
Intussusception 62.33 13.08 34 145102 1136 79598116
Cardiac failure congestive 62.14 13.08 102 145034 142300 79456952
Cardiomyopathy acute 61.93 13.08 23 145113 300 79598952
Cardiac failure 61.91 13.08 488 144648 154354 79444898
Minimal residual disease 61.73 13.08 26 145110 481 79598771
Norovirus test positive 61.29 13.08 28 145108 634 79598618
Clostridium difficile infection 61.28 13.08 194 144942 42491 79556761
Adverse event 60.94 13.08 17 145119 60197 79539055
Balance disorder 59.79 13.08 55 145081 98802 79500450
Tremor 59.36 13.08 139 144997 169944 79429308
Acute hepatitis B 59.28 13.08 25 145111 464 79598788
Bradycardia 59.24 13.08 97 145039 135460 79463792
Pneumocystis jirovecii infection 58.96 13.08 46 145090 2848 79596404
Depressed mood 58.71 13.08 9 145127 48471 79550781
Coagulopathy 58.58 13.08 171 144965 35835 79563417
Flushing 58.43 13.08 45 145091 88223 79511029
Cutaneous calcification 58.39 13.08 18 145118 126 79599126
Therapy non-responder 58.21 13.08 326 144810 91979 79507273
Systemic mycosis 57.87 13.08 44 145092 2622 79596630
Atypical haemolytic uraemic syndrome 57.79 13.08 31 145105 1001 79598251
Chronic obstructive pulmonary disease 57.24 13.08 43 145093 85376 79513876
Pneumonitis 57.17 13.08 241 144895 60619 79538633
Vasogenic cerebral oedema 57.17 13.08 35 145101 1458 79597794
Asthenia 56.95 13.08 626 144510 511063 79088189
5q minus syndrome 56.67 13.08 21 145115 272 79598980
Feeling hot 56.60 13.08 19 145117 59715 79539537
Rash pruritic 56.33 13.08 30 145106 71599 79527653
Viral haemorrhagic cystitis 56.08 13.08 39 145097 2022 79597230
Hepatosplenomegaly 56.01 13.08 62 145074 6007 79593245
Urinary tract infection 55.92 13.08 283 144853 274229 79325023
Weight decreased 55.62 13.08 398 144738 354800 79244452
COVID-19 55.57 13.08 483 144653 157191 79442061
Angioedema 55.31 13.08 35 145101 76000 79523252
Fluid retention 55.25 13.08 29 145107 69780 79529472
Pericarditis 55.14 13.08 65 145071 104171 79495081
Lymphoid tissue hypoplasia 55.09 13.08 29 145107 901 79598351
Respiratory arrest 55.07 13.08 18 145118 57532 79541720
Gastritis bacterial 55.03 13.08 22 145114 354 79598898
Viraemia 55.01 13.08 44 145092 2825 79596427
Vision blurred 55.00 13.08 67 145069 105831 79493421
Hepatosplenic candidiasis 54.85 13.08 25 145111 563 79598689
Immune effector cell-associated neurotoxicity syndrome 54.42 13.08 60 145076 5788 79593464
Treatment noncompliance 54.33 13.08 14 145122 52254 79546998
Pulmonary vascular disorder 54.18 13.08 30 145106 1033 79598219
Enteritis 53.98 13.08 96 145040 14487 79584765
Lung infiltration 53.95 13.08 125 145011 22787 79576465
Pathogen resistance 53.84 13.08 95 145041 14247 79585005
Platelet transfusion 53.83 13.08 40 145096 2302 79596950
BK virus infection 53.73 13.08 73 145063 8731 79590521
Pyomyositis 53.39 13.08 25 145111 600 79598652
Bone marrow disorder 53.14 13.08 46 145090 3297 79595955
Stem cell transplant 52.97 13.08 48 145088 3656 79595596
Enterocolitis infectious 52.89 13.08 43 145093 2826 79596426
Haemolysis 52.21 13.08 88 145048 12724 79586528
Leukaemia 52.06 13.08 59 145077 5866 79593386
Drug reaction with eosinophilia and systemic symptoms 51.86 13.08 26 145110 64218 79535034
Subdural hygroma 51.80 13.08 23 145113 486 79598766
Acute lymphocytic leukaemia refractory 51.42 13.08 17 145119 153 79599099
Swollen tongue 51.33 13.08 8 145128 42562 79556690
Mucosal toxicity 51.26 13.08 24 145112 576 79598676
Peripheral sensorimotor neuropathy 51.08 13.08 43 145093 2967 79596285
Acute myelomonocytic leukaemia 51.07 13.08 20 145116 304 79598948
Hypoalbuminaemia 51.04 13.08 117 145019 21180 79578072
Recurrent cancer 50.99 13.08 41 145095 2652 79596600
Quadriplegia 50.94 13.08 45 145091 3315 79595937
Joint stiffness 50.79 13.08 7 145129 40823 79558429
Hyperpyrexia 50.73 13.08 59 145077 6033 79593219
Multiple-drug resistance 50.70 13.08 71 145065 8737 79590515
International normalised ratio increased 50.22 13.08 48 145088 84673 79514579
B-cell lymphoma 49.77 13.08 59 145077 6156 79593096
Lower respiratory tract infection 49.73 13.08 100 145036 129120 79470132
Adenoviral hepatitis 49.56 13.08 27 145109 900 79598352
Congestive cardiomyopathy 49.45 13.08 82 145054 11698 79587554
Nasal congestion 49.44 13.08 40 145096 76512 79522740
Klebsiella bacteraemia 49.03 13.08 42 145094 2968 79596284
Nephrolithiasis 48.70 13.08 18 145118 53273 79545979
B-cell lymphoma refractory 48.69 13.08 16 145120 141 79599111
Eczema 48.48 13.08 8 145128 40810 79558442
Hypoglycaemia 47.93 13.08 69 145067 101525 79497727
Therapy responder 47.81 13.08 21 145115 432 79598820
Blood stem cell transplant failure 47.56 13.08 22 145114 513 79598739
Pancreatitis 47.15 13.08 248 144888 68327 79530925
Perineal necrosis 46.92 13.08 15 145121 120 79599132
Lymphocytosis 46.90 13.08 50 145086 4643 79594609
Neoplasm 45.94 13.08 69 145067 9047 79590205
Chronic myelomonocytic leukaemia 45.68 13.08 25 145111 841 79598411
Neurological decompensation 45.63 13.08 52 145084 5201 79594051
Babesiosis 45.48 13.08 19 145117 344 79598908
Joint injury 45.21 13.08 3 145133 31332 79567920
Head injury 45.11 13.08 7 145129 37362 79561890
Nervous system disorder 45.09 13.08 129 145007 26727 79572525
Epstein-Barr viraemia 44.82 13.08 35 145101 2170 79597082
Hip arthroplasty 44.79 13.08 6 145130 35750 79563502
Jugular vein thrombosis 44.74 13.08 48 145088 4490 79594762
Amnesia 44.54 13.08 30 145106 63027 79536225
Salivary gland cancer 44.31 13.08 20 145116 440 79598812
Ileus 44.10 13.08 126 145010 26085 79573167
Plasma cell myeloma 43.83 13.08 21 145115 53238 79546014
Abscess bacterial 43.78 13.08 24 145112 810 79598442
Prescribed overdose 43.73 13.08 8 145128 37875 79561377
Staphylococcal infection 43.70 13.08 216 144920 58079 79541173
Rhabdomyosarcoma recurrent 43.26 13.08 14 145122 117 79599135
Colitis ulcerative 43.11 13.08 6 145130 34736 79564516
Cholestasis 42.62 13.08 198 144938 51911 79547341
Limb discomfort 42.39 13.08 5 145131 32845 79566407
Klebsiella sepsis 42.35 13.08 40 145096 3212 79596040
Vertigo 42.29 13.08 38 145098 69044 79530208
Heart rate irregular 42.11 13.08 5 145131 32674 79566578
Limb injury 42.09 13.08 3 145133 29525 79569727
Visual impairment 42.07 13.08 64 145072 92067 79507185
Abdominal neoplasm 41.88 13.08 21 145115 588 79598664
Cryptococcosis 41.78 13.08 41 145095 3452 79595800
Delayed puberty 41.74 13.08 15 145121 177 79599075
Infusion related reaction 41.58 13.08 247 144889 229990 79369262
Gastrointestinal necrosis 41.58 13.08 51 145085 5514 79593738
Body temperature decreased 41.22 13.08 5 145131 32140 79567112
Hypoaesthesia 41.17 13.08 177 144959 179175 79420077
Osteosarcoma 41.00 13.08 18 145118 370 79598882
Cardio-respiratory arrest 40.88 13.08 85 145051 108425 79490827
Leukaemia cutis 40.86 13.08 15 145121 189 79599063
Xanthogranuloma 40.80 13.08 12 145124 70 79599182
Neurological symptom 40.78 13.08 64 145072 8719 79590533
Bone pain 40.69 13.08 205 144931 55537 79543715
Dysgeusia 40.66 13.08 27 145109 57150 79542102
Gastric stenosis 40.26 13.08 14 145122 149 79599103
Wrong technique in product usage process 40.23 13.08 45 145091 73830 79525422
Ganglioneuroblastoma 39.81 13.08 10 145126 28 79599224
Lennox-Gastaut syndrome 39.62 13.08 15 145121 207 79599045
Lentigo 39.61 13.08 19 145117 482 79598770
Drug ineffective 39.61 13.08 2372 142764 1078541 78520711
Peripheral T-cell lymphoma unspecified 39.41 13.08 21 145115 669 79598583
Trichodysplasia spinulosa 39.40 13.08 22 145114 770 79598482
Central nervous system leukaemia 39.38 13.08 18 145118 408 79598844
Injection site haemorrhage 39.25 13.08 3 145133 27867 79571385
Gastric disorder 38.95 13.08 10 145126 37423 79561829
Liver function test abnormal 38.83 13.08 36 145100 64439 79534813
Neuroleptic malignant syndrome 38.72 13.08 3 145133 27556 79571696
Hereditary motor and sensory neuropathy 38.65 13.08 13 145123 124 79599128
Retinal haemorrhage 38.32 13.08 60 145076 8157 79591095
Acute monocytic leukaemia 38.29 13.08 19 145117 520 79598732
Autoimmune lymphoproliferative syndrome 38.23 13.08 14 145122 175 79599077
Ear infection 38.21 13.08 8 145128 34424 79564828
Acne 38.08 13.08 3 145133 27187 79572065
Sopor 38.04 13.08 7 145129 33003 79566249
Cerebral aspergillosis 37.58 13.08 29 145107 1767 79597485
Withdrawal syndrome 37.51 13.08 3 145133 26851 79572401
Encephalitis 37.51 13.08 83 145053 14677 79584575
Venous thrombosis 37.50 13.08 55 145081 7061 79592191
Myeloproliferative neoplasm 37.40 13.08 23 145113 966 79598286
Osteomyelitis bacterial 37.26 13.08 18 145118 464 79598788
Unevaluable event 37.22 13.08 28 145108 55557 79543695
Pulmonary arteriopathy 37.21 13.08 12 145124 99 79599153
Metastases to meninges 37.11 13.08 39 145097 3562 79595690
Combined immunodeficiency 37.11 13.08 12 145124 100 79599152
Nail pigmentation 37.03 13.08 16 145120 316 79598936
Lipase increased 36.77 13.08 88 145048 16378 79582874
Syncope 36.52 13.08 185 144951 179264 79419988
Red blood cell sedimentation rate increased 36.48 13.08 19 145117 45923 79553329
Intracardiac thrombus 36.46 13.08 42 145094 4251 79595001
Meningitis cryptococcal 36.19 13.08 38 145098 3468 79595784
Soft tissue infection 36.16 13.08 40 145096 3872 79595380
Ureaplasma infection 36.13 13.08 23 145113 1027 79598225
Hyperammonaemia 36.00 13.08 69 145067 11024 79588228
Hepatic candidiasis 35.93 13.08 11 145125 75 79599177
Medulloblastoma recurrent 35.91 13.08 12 145124 112 79599140
Premature menopause 35.72 13.08 19 145117 603 79598649
Blood pressure diastolic decreased 35.71 13.08 6 145130 30210 79569042
Central nervous system enteroviral infection 35.56 13.08 11 145125 78 79599174
Localised infection 35.52 13.08 12 145124 37563 79561689
Influenza 35.51 13.08 119 145017 129487 79469765
Iron deficiency anaemia 35.49 13.08 3 145133 25669 79573583
Coronavirus infection 35.32 13.08 55 145081 7442 79591810
Granulocyte count decreased 35.25 13.08 28 145108 1780 79597472
Hyperglycaemia 35.20 13.08 234 144902 70101 79529151
Exposure during pregnancy 34.99 13.08 83 145053 101049 79498203
Chronic myeloid leukaemia 34.80 13.08 38 145098 3626 79595626
Gastrointestinal toxicity 34.79 13.08 57 145079 8052 79591200
Transient ischaemic attack 34.70 13.08 27 145109 52668 79546584
Retinal pigment epitheliopathy 34.54 13.08 17 145119 457 79598795
Stevens-Johnson syndrome 34.51 13.08 14 145122 39152 79560100
Lower respiratory tract infection fungal 34.47 13.08 21 145115 867 79598385
Sciatica 34.33 13.08 9 145127 33213 79566039
Orthostatic hypotension 34.25 13.08 31 145105 56133 79543119
Drug clearance decreased 34.23 13.08 36 145100 3291 79595961
Clostridium test positive 34.18 13.08 50 145086 6404 79592848
Gastroenteritis viral 34.06 13.08 3 145133 24828 79574424
Skin discolouration 34.04 13.08 16 145120 41018 79558234
Oedema 34.00 13.08 108 145028 119472 79479780
Bacillus test positive 33.99 13.08 12 145124 134 79599118
Throat irritation 33.92 13.08 16 145120 40930 79558322
Femur fracture 33.76 13.08 14 145122 38638 79560614
Cardiac disorder 33.72 13.08 42 145094 65715 79533537
Splenic marginal zone lymphoma 33.62 13.08 10 145126 61 79599191
Migraine 33.41 13.08 68 145068 87425 79511827
Nephroblastoma 33.40 13.08 8 145128 17 79599235
B precursor type acute leukaemia 33.14 13.08 16 145120 412 79598840
Mucosal infection 33.08 13.08 17 145119 502 79598750
Swelling face 32.97 13.08 49 145087 71163 79528089
Skin exfoliation 32.91 13.08 31 145105 55069 79544183
Dry eye 32.87 13.08 13 145123 36918 79562334
Cough 32.77 13.08 470 144666 366319 79232933
Bone marrow necrosis 32.52 13.08 14 145122 274 79598978
Central nervous system neoplasm 32.51 13.08 11 145125 107 79599145
Temporal lobe epilepsy 32.51 13.08 16 145120 430 79598822
Acute biphenotypic leukaemia 32.49 13.08 12 145124 154 79599098
Metastases to spleen 32.34 13.08 18 145118 626 79598626
Blood bilirubin increased 32.33 13.08 219 144917 66013 79533239
Electrocardiogram QT prolonged 32.22 13.08 73 145063 90313 79508939
Encephalitis viral 32.22 13.08 31 145105 2548 79596704
Central nervous system fungal infection 32.04 13.08 16 145120 444 79598808
Necrotising gastritis 31.96 13.08 10 145126 74 79599178
Anal inflammation 31.92 13.08 24 145112 1406 79597846
Streptococcal bacteraemia 31.84 13.08 36 145100 3570 79595682
Transverse sinus thrombosis 31.80 13.08 18 145118 647 79598605
Product quality issue 31.80 13.08 11 145125 33929 79565323
Chronic hepatitis 31.67 13.08 24 145112 1423 79597829
Hepatic infection fungal 31.65 13.08 13 145123 225 79599027
Erythropoiesis abnormal 31.59 13.08 16 145120 458 79598794
Pneumonia cytomegaloviral 31.54 13.08 42 145094 4927 79594325
Therapy interrupted 31.43 13.08 9 145127 31332 79567920
Candida pneumonia 31.40 13.08 18 145118 663 79598589
Splenomegaly 31.33 13.08 96 145040 20658 79578594
Optic glioma 31.27 13.08 9 145127 48 79599204
Synovial sarcoma 31.17 13.08 10 145126 81 79599171
Leukaemic lymphoma 31.17 13.08 10 145126 81 79599171
Perineal infection 31.11 13.08 19 145117 788 79598464
Disturbance in attention 31.03 13.08 28 145108 50773 79548479
T-cell type acute leukaemia 30.85 13.08 12 145124 179 79599073
Metastases to bone marrow 30.79 13.08 19 145117 803 79598449
Device issue 30.70 13.08 6 145130 27102 79572150
Cerebral toxoplasmosis 30.66 13.08 29 145107 2333 79596919
Epstein Barr virus positive mucocutaneous ulcer 30.51 13.08 19 145117 816 79598436
Pregnancy 30.29 13.08 6 145130 26845 79572407
Carotid intima-media thickness increased 30.15 13.08 10 145126 91 79599161
Streptococcus test positive 30.05 13.08 28 145108 2210 79597042
Klebsiella test positive 30.04 13.08 25 145111 1698 79597554
Hyperkalaemia 30.01 13.08 107 145029 114291 79484961
Rib fracture 29.99 13.08 7 145129 27940 79571312
Tendonitis 29.84 13.08 4 145132 23826 79575426
Transformation to acute myeloid leukaemia 29.81 13.08 20 145116 977 79598275
Tumour necrosis 29.65 13.08 26 145110 1896 79597356
Nephropathy toxic 29.48 13.08 93 145043 20326 79578926
Haematochezia 29.48 13.08 73 145063 87572 79511680
Myelitis transverse 29.36 13.08 26 145110 1921 79597331
Device related thrombosis 29.35 13.08 30 145106 2653 79596599
Tooth disorder 29.31 13.08 6 145130 26227 79573025
Metapneumovirus infection 29.28 13.08 25 145111 1759 79597493
Foot fracture 29.24 13.08 3 145133 21978 79577274
Medication error 29.16 13.08 50 145086 68592 79530660
Eye pain 29.16 13.08 16 145120 37562 79561690
Therapy cessation 29.14 13.08 16 145120 37546 79561706
Kidney infection 29.02 13.08 3 145133 21848 79577404
Gait inability 28.80 13.08 39 145097 58878 79540374
Histiocytic sarcoma 28.72 13.08 9 145127 67 79599185
Chromosomal deletion 28.72 13.08 11 145125 157 79599095
Disseminated cryptococcosis 28.68 13.08 25 145111 1809 79597443
Paraparesis 28.65 13.08 35 145101 3768 79595484
Meningitis tuberculous 28.64 13.08 21 145115 1184 79598068
Hypersomnia 28.62 13.08 4 145132 23082 79576170
Skin toxicity 28.57 13.08 53 145083 8261 79590991
Escherichia test positive 28.55 13.08 32 145104 3143 79596109
Respiratory tract infection fungal 28.51 13.08 21 145115 1192 79598060
Diffuse alveolar damage 28.51 13.08 34 145102 3570 79595682
Depressed level of consciousness 28.39 13.08 86 145050 96566 79502686
Refractory cancer 28.39 13.08 12 145124 224 79599028
Chronic kidney disease 28.28 13.08 48 145088 66106 79533146
Leukoerythroblastosis 28.27 13.08 13 145123 299 79598953
Hypertension 28.22 13.08 428 144708 330564 79268688
Panic attack 28.20 13.08 5 145131 24211 79575041
Acute hepatic failure 28.08 13.08 119 145017 29994 79569258
Retroperitoneal lymphadenopathy 28.04 13.08 20 145116 1080 79598172
Blood potassium decreased 27.97 13.08 26 145110 46486 79552766
Cardiac dysfunction 27.95 13.08 36 145100 4088 79595164
Oesophageal stenosis 27.94 13.08 37 145099 4317 79594935
Metastases to peritoneum 27.82 13.08 37 145099 4335 79594917
Toxic neuropathy 27.74 13.08 19 145117 961 79598291
Geotrichum infection 27.72 13.08 19 145117 962 79598290
Acute lung injury 27.46 13.08 31 145105 3069 79596183
Disorder of orbit 27.38 13.08 10 145126 124 79599128
Bone marrow infiltration 27.32 13.08 17 145119 729 79598523
Ankle brachial index decreased 27.32 13.08 9 145127 80 79599172
Cerebral salt-wasting syndrome 27.24 13.08 10 145126 126 79599126
Hip fracture 27.09 13.08 11 145125 30750 79568502
Pulse waveform abnormal 27.03 13.08 9 145127 83 79599169
Viral load increased 27.00 13.08 30 145106 2918 79596334
Blood HIV RNA increased 26.98 13.08 24 145112 1784 79597468
Prescribed underdose 26.91 13.08 10 145126 29504 79569748
Abortion spontaneous 26.90 13.08 10 145126 29497 79569755
B-cell type acute leukaemia 26.79 13.08 15 145121 528 79598724
Ocular hyperaemia 26.67 13.08 9 145127 28197 79571055
Pancreatitis acute 26.64 13.08 168 144968 49436 79549816
Meningoencephalitis viral 26.59 13.08 14 145122 435 79598817
Mediastinum neoplasm 26.56 13.08 9 145127 88 79599164
Heart rate abnormal 26.56 13.08 43 145093 6014 79593238
Delirium 26.54 13.08 73 145063 84554 79514698
Epidermal necrosis 26.42 13.08 22 145114 1495 79597757
Sputum discoloured 26.41 13.08 4 145132 21739 79577513
Metastasis 26.38 13.08 46 145090 6834 79592418
Neutropenic infection 26.30 13.08 27 145109 2400 79596852
Ureteric compression 26.30 13.08 12 145124 271 79598981
Cellulitis gangrenous 26.30 13.08 12 145124 271 79598981
Capillary leak syndrome 26.19 13.08 34 145102 3891 79595361
Diverticulitis 26.10 13.08 27 145109 45909 79553343
Encephalitis enteroviral 26.09 13.08 10 145126 143 79599109
Pneumonia necrotising 26.08 13.08 20 145116 1207 79598045
Haematopoietic stem cell mobilisation 26.04 13.08 11 145125 205 79599047
Subclavian vein thrombosis 26.02 13.08 27 145109 2430 79596822
Tissue infiltration 25.95 13.08 16 145120 675 79598577
Ameloblastoma 25.95 13.08 9 145127 95 79599157
Dyspnoea exertional 25.92 13.08 77 145059 86996 79512256
Small intestinal perforation 25.91 13.08 31 145105 3266 79595986
Cytomegalovirus colitis 25.84 13.08 37 145099 4648 79594604
Gastrointestinal inflammation 25.81 13.08 48 145088 7496 79591756
Respiratory depression 25.81 13.08 9 145127 27621 79571631
Transaminases increased 25.80 13.08 172 144964 51571 79547681
Diabetic ketoacidosis 25.80 13.08 15 145121 34107 79565145
Emotional distress 25.66 13.08 21 145115 39948 79559304
Positron emission tomogram abnormal 25.64 13.08 13 145123 373 79598879
Follicular lymphoma 25.64 13.08 13 145123 373 79598879
Iris atrophy 25.53 13.08 10 145126 152 79599100
Cerebellar syndrome 25.53 13.08 40 145096 5440 79593812
Blood calcium decreased 25.50 13.08 13 145123 31806 79567446
Molluscum contagiosum 25.47 13.08 14 145122 475 79598777
Tracheo-oesophageal fistula 25.26 13.08 15 145121 591 79598661
Basal cell naevus syndrome 25.21 13.08 7 145129 32 79599220
Intestinal atresia 25.03 13.08 8 145128 64 79599188
Pulmonary haemorrhage 25.01 13.08 71 145065 14646 79584606
Trichosporon infection 24.94 13.08 18 145118 990 79598262
Blood potassium increased 24.93 13.08 11 145125 29264 79569988
Traumatic lung injury 24.83 13.08 26 145110 2365 79596887
Myelitis 24.83 13.08 26 145110 2365 79596887
Post-acute COVID-19 syndrome 24.79 13.08 14 145122 501 79598751
Acute respiratory distress syndrome 24.76 13.08 151 144985 43916 79555336
Hepatitis 24.70 13.08 180 144956 55547 79543705
Marginal zone lymphoma recurrent 24.70 13.08 7 145129 35 79599217
Blood pressure diastolic abnormal 24.59 13.08 3 145133 19199 79580053
Restlessness 24.57 13.08 29 145107 46463 79552789
Administration site extravasation 24.49 13.08 20 145116 1323 79597929
Renal replacement therapy 24.41 13.08 10 145126 172 79599080
Flatulence 24.40 13.08 25 145111 42699 79556553
Renal tubular disorder 24.39 13.08 43 145093 6443 79592809
Chromosome analysis abnormal 24.37 13.08 11 145125 242 79599010
Osteoporosis 24.31 13.08 38 145098 54074 79545178
Erythropenia 24.29 13.08 13 145123 418 79598834
Apraxia 24.26 13.08 28 145108 2839 79596413
Delusion 24.26 13.08 4 145132 20419 79578833
Labelled drug-drug interaction medication error 24.17 13.08 10 145126 27640 79571612
Subacute combined cord degeneration 24.16 13.08 12 145124 329 79598923
Rhinocerebral mucormycosis 24.16 13.08 18 145118 1040 79598212
Feeling cold 24.15 13.08 11 145125 28718 79570534
Humoral immune defect 24.15 13.08 13 145123 423 79598829
White blood cell count abnormal 24.13 13.08 40 145096 5705 79593547
Graft versus host disease 24.09 13.08 71 145065 14955 79584297
Mass 23.79 13.08 78 145058 17394 79581858
Hypertransaminasaemia 23.75 13.08 61 145075 11863 79587389
Ovarian failure 23.74 13.08 15 145121 661 79598591
Chronic hepatitis B 23.73 13.08 13 145123 438 79598814
Extrapyramidal disorder 23.71 13.08 6 145130 22673 79576579
Metastases to lymph nodes 23.69 13.08 56 145080 10341 79588911
Paraesthesia 23.64 13.08 206 144930 176117 79423135
Thirst 23.62 13.08 3 145133 18616 79580636
Muscle rigidity 23.38 13.08 4 145132 19878 79579374
Accidental exposure to product 23.36 13.08 14 145122 31308 79567944
Photosensitivity reaction 23.26 13.08 5 145131 21122 79578130
Sinusitis fungal 23.21 13.08 25 145111 2349 79596903
Gastric pneumatosis 23.10 13.08 6 145130 20 79599232
Thrombocytopenia neonatal 23.10 13.08 6 145130 20 79599232
Rectal haemorrhage 23.05 13.08 67 145069 76233 79523019
Blindness cortical 23.00 13.08 17 145119 970 79598282
Dehydration 22.87 13.08 316 144820 247871 79351381
Encephalitis cytomegalovirus 22.83 13.08 18 145118 1132 79598120
Aggression 22.69 13.08 36 145100 50922 79548330
Breast cancer 22.64 13.08 17 145119 33764 79565488
Malnutrition 22.62 13.08 91 145045 22411 79576841
Anorectal cellulitis 22.61 13.08 8 145128 90 79599162
Herpes simplex encephalitis 22.58 13.08 15 145121 721 79598531
Paranasal sinus mucosal hypertrophy 22.53 13.08 8 145128 91 79599161
Injection site rash 22.52 13.08 3 145133 17951 79581301
Pneumoperitoneum 22.44 13.08 28 145108 3080 79596172
Vocal cord paresis 22.41 13.08 11 145125 294 79598958
Stomatococcal infection 22.41 13.08 11 145125 294 79598958
Neurofibrosarcoma 22.41 13.08 10 145126 214 79599038
Pharyngeal inflammation 22.36 13.08 17 145119 1013 79598239
Taeniasis 22.35 13.08 7 145129 52 79599200
Streptococcal sepsis 22.30 13.08 27 145109 2880 79596372
Tooth malformation 22.28 13.08 9 145127 149 79599103
Loss of CAR T-cell persistence 22.25 13.08 6 145130 24 79599228
Helicobacter sepsis 22.25 13.08 6 145130 24 79599228
Autonomic neuropathy 22.22 13.08 22 145114 1873 79597379
Pneumonia adenoviral 22.19 13.08 13 145123 499 79598753
Jejunal stenosis 22.14 13.08 8 145128 96 79599156
Hypophagia 22.14 13.08 150 144986 45217 79554035
Herpes zoster meningoencephalitis 22.12 13.08 15 145121 746 79598506
Immunosuppression 21.98 13.08 62 145074 12741 79586511
Rash erythematous 21.96 13.08 45 145091 57724 79541528
Chloroma 21.96 13.08 15 145121 755 79598497
Listeria sepsis 21.93 13.08 15 145121 757 79598495
Drug ineffective for unapproved indication 21.86 13.08 164 144972 51074 79548178
Blood creatinine increased 21.75 13.08 179 144957 154878 79444374
Cytomegalovirus hepatitis 21.72 13.08 15 145121 769 79598483
Sphingomonas paucimobilis infection 21.70 13.08 8 145128 102 79599150
Adenocarcinoma gastric 21.68 13.08 21 145115 1740 79597512
Accidental overdose 21.67 13.08 24 145112 39557 79559695
Obstruction gastric 21.59 13.08 21 145115 1749 79597503
Drug eruption 21.56 13.08 29 145107 43906 79555346
Bacterial translocation 21.54 13.08 14 145122 648 79598604
Pyloric stenosis 21.53 13.08 13 145123 528 79598724
Aspiration bone marrow abnormal 21.49 13.08 9 145127 164 79599088
Pericardial effusion 21.45 13.08 151 144985 46086 79553166
Rash macular 21.43 13.08 13 145123 28886 79570366
Lymphocytic leukaemia 21.43 13.08 10 145126 238 79599014
Microgenia 21.42 13.08 5 145131 9 79599243
Obliterative bronchiolitis 21.42 13.08 27 145109 3001 79596251
Respiratory tract congestion 21.41 13.08 5 145131 19949 79579303
Product administration error 21.37 13.08 16 145120 31830 79567422
Cerebral thrombosis 21.37 13.08 24 145112 2363 79596889
Blood pressure systolic abnormal 21.35 13.08 3 145133 17244 79582008
Candida endophthalmitis 21.34 13.08 9 145127 167 79599085
Sinus congestion 21.32 13.08 5 145131 19891 79579361
Hyperleukocytosis 21.27 13.08 25 145111 2585 79596667
Cryptococcal fungaemia 21.20 13.08 9 145127 170 79599082
Hepatitis B surface antigen positive 21.20 13.08 9 145127 170 79599082
Hepatitis B DNA increased 21.19 13.08 15 145121 800 79598452
Urinary bladder rupture 21.16 13.08 8 145128 110 79599142
Abnormal behaviour 21.16 13.08 21 145115 36400 79562852
Cerebellar stroke 21.14 13.08 13 145123 546 79598706
Basal ganglion degeneration 21.08 13.08 12 145124 436 79598816
Coronavirus test positive 20.98 13.08 17 145119 1112 79598140
Pneumonia klebsiella 20.97 13.08 35 145101 5019 79594233
Pneumococcal bacteraemia 20.96 13.08 8 145128 113 79599139
Oxygen saturation decreased 20.94 13.08 143 144993 128904 79470348
Therapeutic response delayed 20.81 13.08 17 145119 1125 79598127
Neuroendocrine carcinoma of the skin 20.75 13.08 18 145118 1294 79597958
Bladder cancer 20.74 13.08 5 145131 19521 79579731
Rhinorrhoea 20.73 13.08 70 145066 76004 79523248
Obesity 20.69 13.08 20 145116 35105 79564147
Campylobacter infection 20.69 13.08 21 145115 1842 79597410
Eye irritation 20.63 13.08 6 145130 20675 79578577
Platelet count abnormal 20.62 13.08 34 145102 4828 79594424
Primary immunodeficiency syndrome 20.61 13.08 7 145129 69 79599183
Refractory cytopenia with multilineage dysplasia 20.59 13.08 10 145126 261 79598991
Fracture 20.54 13.08 7 145129 21794 79577458
Pneumonia viral 20.51 13.08 49 145087 9109 79590143
Pulmonary mucormycosis 20.51 13.08 17 145119 1148 79598104
Wound infection 20.45 13.08 9 145127 23982 79575270
Otitis media acute 20.45 13.08 18 145118 1319 79597933
Candida sepsis 20.36 13.08 24 145112 2489 79596763
Hydrocephalus 20.34 13.08 48 145088 8852 79590400
Paraesthesia oral 20.30 13.08 6 145130 20465 79578787
Acute myocardial infarction 20.24 13.08 72 145064 76964 79522288
Retinopathy proliferative 20.23 13.08 8 145128 125 79599127
Campylobacter gastroenteritis 20.13 13.08 18 145118 1347 79597905
Splenic candidiasis 20.09 13.08 7 145129 75 79599177
Lymphadenitis viral 20.09 13.08 7 145129 75 79599177
Haemolytic uraemic syndrome 20.07 13.08 32 145104 4417 79594835
SARS-CoV-2 test negative 20.06 13.08 18 145118 1353 79597899
Pulmonary sarcoidosis 20.00 13.08 18 145118 1359 79597893
Extramedullary haemopoiesis 19.94 13.08 8 145128 130 79599122
Primary mediastinal large B-cell lymphoma recurrent 19.92 13.08 7 145129 77 79599175
Cataract 19.92 13.08 53 145083 62067 79537185
Creatinine renal clearance decreased 19.92 13.08 5 145131 18997 79580255
Congenital herpes simplex infection 19.90 13.08 5 145131 14 79599238
Papillary thyroid cancer 19.81 13.08 24 145112 2562 79596690
Hepatitis viral 19.80 13.08 16 145120 1042 79598210
Blood urine present 19.78 13.08 7 145129 21290 79577962
Coma 19.77 13.08 105 145031 100544 79498708
Uterine enlargement 19.74 13.08 15 145121 893 79598359
Restless legs syndrome 19.73 13.08 6 145130 20086 79579166
Neutrophil count abnormal 19.67 13.08 28 145108 3498 79595754
Neuroborreliosis 19.67 13.08 8 145128 135 79599117
Hepatic infarction 19.64 13.08 15 145121 900 79598352
Obstructive airways disorder 19.62 13.08 17 145119 31442 79567810
Agitation 19.60 13.08 104 145032 99611 79499641
Lymphoproliferative disorder 19.55 13.08 36 145100 5579 79593673
Metastases to retroperitoneum 19.50 13.08 11 145125 393 79598859
Fanconi syndrome 19.47 13.08 25 145111 2831 79596421
Underdose 19.39 13.08 19 145117 33132 79566120
Blastic plasmacytoid dendritic cell neoplasia 19.37 13.08 7 145129 84 79599168
Musculoskeletal discomfort 19.34 13.08 6 145130 19829 79579423
Gastroenteritis norovirus 19.33 13.08 26 145110 3080 79596172
Pleocytosis 19.32 13.08 18 145118 1421 79597831
Diabetes mellitus inadequate control 19.31 13.08 10 145126 24254 79574998
Premature ageing 19.23 13.08 7 145129 86 79599166
Human polyomavirus infection 19.18 13.08 16 145120 1090 79598162
Blood glucose decreased 19.18 13.08 12 145124 26222 79573030
Intracranial pressure increased 19.15 13.08 45 145091 8277 79590975
T-cell prolymphocytic leukaemia 19.11 13.08 6 145130 45 79599207
Suspected product quality issue 19.10 13.08 10 145126 307 79598945
Lip swelling 19.08 13.08 28 145108 40883 79558369
Oophoritis 19.08 13.08 7 145129 88 79599164
Enterocolitis 19.06 13.08 64 145072 14448 79584804
Pleuroparenchymal fibroelastosis 19.04 13.08 8 145128 147 79599105
Plasminogen decreased 19.01 13.08 4 145132 3 79599249
Hypertensive crisis 19 13.08 7 145129 20763 79578489
Astrocytoma 18.99 13.08 9 145127 222 79599030
Maternal exposure during pregnancy 18.98 13.08 158 144978 136380 79462872
Spinal stenosis 18.96 13.08 3 145133 15788 79583464
Miosis 18.96 13.08 3 145133 15786 79583466
Microsporidia infection 18.92 13.08 15 145121 951 79598301
Blood immunoglobulin G decreased 18.91 13.08 27 145109 3382 79595870
Leukonychia 18.88 13.08 6 145130 47 79599205
Throat tightness 18.76 13.08 14 145122 27893 79571359
Melaena 18.74 13.08 53 145083 60837 79538415
Alveolar soft part sarcoma 18.73 13.08 7 145129 93 79599159
Facial paresis 18.71 13.08 35 145101 5491 79593761
Liver tenderness 18.70 13.08 10 145126 321 79598931
Administration related reaction 18.63 13.08 9 145127 232 79599020
Hepatic cytolysis 18.53 13.08 98 145038 27053 79572199
Toxicity to various agents 18.36 13.08 606 144530 420934 79178318
Vagus nerve paralysis 18.35 13.08 5 145131 21 79599231
Decreased appetite 18.22 13.08 479 144657 341939 79257313
Renal salt-wasting syndrome 18.21 13.08 13 145123 703 79598549
Ageusia 18.18 13.08 4 145132 16628 79582624
Seizure 18.12 13.08 461 144675 188373 79410879
Growth failure 18.12 13.08 9 145127 247 79599005
Gastrointestinal disorder 18.10 13.08 139 144997 122066 79477186
Hepatic amoebiasis 18.02 13.08 7 145129 104 79599148
Sleep apnoea syndrome 17.98 13.08 24 145112 36454 79562798
Gastrointestinal obstruction 17.92 13.08 19 145117 1753 79597499
Metastases to muscle 17.91 13.08 10 145126 350 79598902
Movement disorder 17.90 13.08 14 145122 27245 79572007
Poisoning 17.88 13.08 12 145124 25260 79573992
Peritonitis viral 17.86 13.08 6 145130 57 79599195
Human herpesvirus 8 infection 17.82 13.08 16 145120 1204 79598048
Enterobacter bacteraemia 17.79 13.08 14 145122 878 79598374
Skin cancer 17.74 13.08 3 145133 15037 79584215
Splenic infection fungal 17.66 13.08 7 145129 110 79599142
Cholelithiasis 17.60 13.08 44 145092 52620 79546632
Cutaneous T-cell lymphoma recurrent 17.59 13.08 6 145130 60 79599192
Hypogonadism male 17.56 13.08 8 145128 180 79599072
Eosinophilia 17.51 13.08 35 145101 45310 79553942
Glaucoma 17.51 13.08 7 145129 19754 79579498
Superior vena cava syndrome 17.50 13.08 16 145120 1233 79598019
Device dislocation 17.49 13.08 13 145123 25957 79573295
VIth nerve paralysis 17.48 13.08 18 145118 1606 79597646
Proteinuria 17.47 13.08 20 145116 32482 79566770
Listeriosis 17.43 13.08 21 145115 2229 79597023
Streptococcal infection 17.41 13.08 45 145091 8785 79590467
Urethral obstruction 17.35 13.08 9 145127 271 79598981
Carnitine deficiency 17.32 13.08 9 145127 272 79598980
Pneumothorax spontaneous 17.27 13.08 17 145119 1437 79597815
Mantle cell lymphoma refractory 17.27 13.08 7 145129 117 79599135
Antithrombin III deficiency 17.27 13.08 7 145129 117 79599135
Non-alcoholic steatohepatitis 17.26 13.08 21 145115 2251 79597001
Inflammation 17.22 13.08 100 145036 93653 79505599
Chronic lymphocytic leukaemia refractory 17.16 13.08 7 145129 119 79599133
Haematoma 17.14 13.08 44 145092 52151 79547101
Brain oedema 17.11 13.08 91 145045 25172 79574080
Paraplegia 17.10 13.08 32 145104 5021 79594231
Staphylococcus test positive 17.10 13.08 37 145099 6444 79592808
Hyperglycaemic hyperosmolar nonketotic syndrome 17.03 13.08 21 145115 2282 79596970
Lactic acidosis 17.03 13.08 68 145068 70291 79528961
Disseminated aspergillosis 17 13.08 15 145121 1103 79598149
Clostridium bacteraemia 16.98 13.08 10 145126 388 79598864
Cardiac murmur 16.91 13.08 4 145132 15820 79583432
Enterococcus test positive 16.89 13.08 20 145116 2084 79597168
Pneumaturia 16.88 13.08 5 145131 30 79599222
Eye swelling 16.88 13.08 14 145122 26454 79572798
Tachypnoea 16.85 13.08 108 145028 31955 79567297
Lacrimation increased 16.82 13.08 10 145126 22467 79576785
Glycosylated haemoglobin increased 16.78 13.08 7 145129 19253 79579999
Joint dislocation 16.74 13.08 5 145131 16934 79582318
Rectal fissure 16.69 13.08 14 145122 961 79598291
Vulvovaginitis 16.63 13.08 9 145127 296 79598956
Primitive neuroectodermal tumour 16.61 13.08 5 145131 32 79599220
Joint effusion 16.60 13.08 6 145130 18008 79581244
Bacillus infection 16.58 13.08 15 145121 1140 79598112
Lung opacity 16.56 13.08 32 145104 5142 79594110
Corynebacterium infection 16.56 13.08 16 145120 1322 79597930
Fungal oesophagitis 16.53 13.08 14 145122 974 79598278
Intestinal pseudo-obstruction 16.48 13.08 22 145114 2587 79596665
Vulvovaginal inflammation 16.44 13.08 11 145125 535 79598717
Selective mutism 16.39 13.08 6 145130 75 79599177
Hypercholesterolaemia 16.29 13.08 11 145125 23084 79576168
Eye opacity 16.25 13.08 4 145132 10 79599242
Growth hormone deficiency 16.24 13.08 10 145126 421 79598831
Crying 16.22 13.08 11 145125 23032 79576220
Brain injury 16.21 13.08 52 145084 11465 79587787
Tooth infection 16.16 13.08 7 145129 18825 79580427
Angina unstable 16.11 13.08 5 145131 16522 79582730
Genotoxicity 16.10 13.08 5 145131 36 79599216
Haemoglobin abnormal 16.08 13.08 38 145098 7016 79592236
Food protein-induced enterocolitis syndrome 15.98 13.08 5 145131 37 79599215
Cold sweat 15.97 13.08 7 145129 18692 79580560
Seasonal allergy 15.93 13.08 5 145131 16401 79582851
Pneumonia pseudomonal 15.88 13.08 34 145102 5877 79593375
Splenic lesion 15.87 13.08 11 145125 567 79598685
Morphoea 15.86 13.08 10 145126 439 79598813
Engraftment syndrome 15.86 13.08 16 145120 1393 79597859
Bacillus bacteraemia 15.85 13.08 7 145129 146 79599106
Retinal toxicity 15.84 13.08 16 145120 1395 79597857
Eating disorder 15.79 13.08 9 145127 20688 79578564
Metapneumovirus bronchiolitis 15.72 13.08 4 145132 12 79599240
Paraneoplastic pemphigus 15.72 13.08 7 145129 149 79599103
Haematocrit decreased 15.65 13.08 58 145078 61254 79537998
Chemotherapeutic drug level above therapeutic 15.64 13.08 6 145130 86 79599166
Lewis-Sumner syndrome 15.64 13.08 5 145131 40 79599212
Antithrombin III 15.58 13.08 6 145130 87 79599165
Faeces discoloured 15.57 13.08 18 145118 29109 79570143
Cancer in remission 15.53 13.08 5 145131 41 79599211
Right ventricular failure 15.52 13.08 12 145124 23485 79575767
Transplant rejection 15.49 13.08 8 145128 19429 79579823
C-reactive protein increased 15.46 13.08 155 144981 128872 79470380
Diverticulum 15.46 13.08 4 145132 14892 79584360
Sinus disorder 15.45 13.08 11 145125 22453 79576799
Laboratory test abnormal 15.36 13.08 17 145119 28031 79571221
Disseminated cytomegaloviral infection 15.35 13.08 10 145126 465 79598787
Alanine aminotransferase increased 15.33 13.08 396 144740 162174 79437078
Gastrointestinal protozoal infection 15.33 13.08 6 145130 91 79599161
Sinus bradycardia 15.32 13.08 14 145122 25233 79574019
Arteriosclerosis 15.29 13.08 7 145129 18220 79581032
Hiatus hernia 15.28 13.08 12 145124 23300 79575952
Skin abrasion 15.19 13.08 3 145133 13453 79585799
Aborted pregnancy 15.12 13.08 5 145131 45 79599207
Blood alkaline phosphatase increased 15.11 13.08 62 145074 63602 79535650
Bone sarcoma 15.10 13.08 6 145130 95 79599157
Lymphadenopathy mediastinal 15.08 13.08 28 145108 4368 79594884
Intervertebral disc degeneration 14.99 13.08 5 145131 15780 79583472
Chronic lymphocytic leukaemia transformation 14.92 13.08 8 145128 258 79598994
Infection parasitic 14.92 13.08 10 145126 488 79598764
Skin burning sensation 14.90 13.08 3 145133 13269 79585983
Akathisia 14.88 13.08 3 145133 13256 79585996
Acute leukaemia 14.85 13.08 17 145119 1709 79597543
Beta 2 microglobulin decreased 14.83 13.08 4 145132 16 79599236
Pneumonia aspiration 14.80 13.08 67 145069 66900 79532352
Splenic necrosis 14.80 13.08 7 145129 172 79599080
Cellulitis orbital 14.78 13.08 12 145124 787 79598465
Acral lentiginous melanoma 14.75 13.08 5 145131 49 79599203
Chronic lymphocytic leukaemia recurrent 14.74 13.08 11 145125 637 79598615
Flagellate dermatitis 14.73 13.08 8 145128 265 79598987
Thinking abnormal 14.72 13.08 3 145133 13158 79586094
Electrocardiogram abnormal 14.72 13.08 6 145130 16731 79582521
Hallucination, visual 14.69 13.08 23 145113 32706 79566546
Emotional disorder 14.67 13.08 4 145132 14383 79584869
Respiratory syncytial virus infection 14.67 13.08 44 145092 9358 79589894
Tessellated fundus 14.66 13.08 5 145131 50 79599202
KMT2A gene mutation 14.64 13.08 4 145132 17 79599235
Paratracheal lymphadenopathy 14.54 13.08 7 145129 179 79599073
Poor quality sleep 14.51 13.08 12 145124 22710 79576542
Primary hypogonadism 14.51 13.08 7 145129 180 79599072
Myocardial ischaemia 14.50 13.08 15 145121 25504 79573748
Lip dry 14.44 13.08 5 145131 15413 79583839
Adenoviral haemorrhagic cystitis 14.44 13.08 10 145126 515 79598737
Salivary hypersecretion 14.42 13.08 4 145132 14220 79585032
Hallucination, auditory 14.40 13.08 10 145126 20683 79578569
Plasmablastic lymphoma 14.40 13.08 10 145126 517 79598735
Anaesthesia 14.40 13.08 10 145126 517 79598735
Cardiomegaly 14.40 13.08 16 145120 26336 79572916
Fasciitis 14.37 13.08 12 145124 819 79598433
Anal ulcer 14.34 13.08 15 145121 1363 79597889
Hepatic cirrhosis 14.31 13.08 26 145110 34880 79564372
Coronary artery occlusion 14.28 13.08 5 145131 15310 79583942
IIIrd nerve paralysis 14.26 13.08 14 145122 1179 79598073
Leukaemic infiltration extramedullary 14.23 13.08 7 145129 188 79599064
Meningitis bacterial 14.23 13.08 21 145115 2711 79596541
Graft versus host disease in gastrointestinal tract 14.23 13.08 34 145102 6322 79592930
Hepatic haemorrhage 14.23 13.08 13 145123 1001 79598251
Feeling jittery 14.21 13.08 3 145133 12838 79586414
Atrial fibrillation 14.19 13.08 264 144872 197622 79401630
Stenotrophomonas infection 14.17 13.08 25 145111 3748 79595504
Muscle spasticity 14.14 13.08 11 145125 21464 79577788
Genital infection 14.13 13.08 7 145129 191 79599061
Perirectal abscess 14.12 13.08 18 145118 2023 79597229
Malignant neoplasm of orbit 14.11 13.08 4 145132 20 79599232
Parvovirus infection 14.09 13.08 11 145125 682 79598570
Pneumopericardium 14.06 13.08 7 145129 193 79599059
Mental disorder 14.04 13.08 22 145114 31280 79567972
Pharyngeal oedema 14.04 13.08 6 145130 16266 79582986
Feeding intolerance 14.01 13.08 12 145124 848 79598404
Abdominal mass 13.98 13.08 24 145112 3521 79595731
Precursor T-lymphoblastic lymphoma/leukaemia recurrent 13.95 13.08 4 145132 21 79599231
Human metapneumovirus test positive 13.90 13.08 7 145129 198 79599054
Vaccination failure 13.87 13.08 17 145119 1836 79597416
Dysaesthesia 13.87 13.08 32 145104 5816 79593436
Ataxia telangiectasia 13.86 13.08 3 145133 3 79599249
Listeria encephalitis 13.80 13.08 8 145128 301 79598951
Stomatitis necrotising 13.74 13.08 7 145129 203 79599049
Hypouricaemia 13.73 13.08 9 145127 423 79598829
Shunt infection 13.67 13.08 7 145129 205 79599047
Dermatitis allergic 13.66 13.08 8 145128 18122 79581130
Diabetes mellitus 13.66 13.08 85 145051 78305 79520947
Acinetobacter sepsis 13.62 13.08 5 145131 63 79599189
Metabolic acidosis 13.61 13.08 91 145045 82438 79516814
Cystitis viral 13.61 13.08 11 145125 717 79598535
Histoplasmosis disseminated 13.59 13.08 19 145117 2334 79596918
Post procedural complication 13.54 13.08 14 145122 23815 79575437
Ulcer 13.51 13.08 21 145115 29951 79569301
Rales 13.48 13.08 10 145126 19991 79579261
Sinus tachycardia 13.48 13.08 114 145022 36794 79562458
Dementia 13.44 13.08 15 145121 24644 79574608
Deafness neurosensory 13.44 13.08 35 145101 6863 79592389
Philadelphia positive acute lymphocytic leukaemia 13.41 13.08 5 145131 66 79599186
B-cell aplasia 13.40 13.08 7 145129 214 79599038
Mononeuropathy multiplex 13.39 13.08 9 145127 441 79598811
Human herpesvirus 7 infection 13.38 13.08 6 145130 130 79599122
Haemolytic anaemia 13.33 13.08 66 145070 17754 79581498
Rhinitis allergic 13.31 13.08 3 145133 12266 79586986
Intervertebral disc protrusion 13.29 13.08 14 145122 23607 79575645
T-cell lymphoma recurrent 13.27 13.08 5 145131 68 79599184
Ecthyma 13.24 13.08 11 145125 745 79598507
T-cell lymphoma 13.23 13.08 14 145122 1289 79597963
Cranial nerve disorder 13.22 13.08 13 145123 1097 79598155
Blood urea increased 13.22 13.08 45 145091 48745 79550507
Pelvic fracture 13.21 13.08 3 145133 12201 79587051
Peroneal nerve palsy 13.18 13.08 32 145104 6010 79593242
Generalised tonic-clonic seizure 13.18 13.08 130 145006 43780 79555472
Angina pectoris 13.16 13.08 49 145087 51683 79547569
Tuberculosis liver 13.14 13.08 5 145131 70 79599182
Anaplastic lymphoma kinase gene mutation 13.09 13.08 6 145130 137 79599115

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01CA02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Vinca alkaloids and analogues
FDA CS M0022674 Vinca Alkaloids
FDA EPC N0000175612 Vinca Alkaloid
CHEBI has role CHEBI:23888 drugs
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:60832 tubulin modulators
CHEBI has role CHEBI:61951 microtubule destabilizing role
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:176497 geroprotectors
MeSH PA D050256 Antimitotic Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000972 Antineoplastic Agents, Phytogenic
MeSH PA D050257 Tubulin Modulators

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acute lymphoid leukemia indication 91857003 DOID:9952
Diffuse non-Hodgkin's lymphoma, large cell indication 109969005
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Rhabdomyosarcoma indication 302847003 DOID:3247
Nephroblastoma indication 302849000 DOID:2154
Follicular non-Hodgkin's lymphoma indication 308121000
Neuroblastoma indication 432328008 DOID:769
Astrocytoma, anaplastic off-label use 55353007 DOID:3078
Ewing's sarcoma off-label use 76909002 DOID:3369
Chronic lymphoid leukemia, disease off-label use 92814006
Multiple myeloma off-label use 109989006 DOID:9538
Mycosis fungoides off-label use 118618005
Small cell carcinoma of lung off-label use 254632001 DOID:5409
Glioblastoma multiforme of brain off-label use 276828006 DOID:3073
Primary cutaneous T-cell lymphoma off-label use 400122007
Ovarian Germ Cell Tumor Carcinoma off-label use
Mycosis contraindication 3218000 DOID:1564
Hyperbilirubinemia contraindication 14783006 DOID:2741
Obstruction of bile duct contraindication 30144000
Viral disease contraindication 34014006 DOID:934
Hyperuricemia contraindication 35885006 DOID:1920
Charcot-Marie-Tooth disease contraindication 50548001
Hepatic failure contraindication 59927004
Leukopenia contraindication 84828003 DOID:615
Bacterial infectious disease contraindication 87628006
Peripheral motor neuropathy contraindication 95663000 DOID:683
Neuromyopathy contraindication 255522009 DOID:440
Uric acid renal calculus contraindication 274401005
Pregnancy, function contraindication 289908002
Peripheral nerve disease contraindication 302226006
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Protozoal Infection contraindication
Polyneuropathies contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.02 acidic
pKa2 13.81 acidic
pKa3 7.2 Basic
pKa4 6.58 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Tubulin beta Tumour-associated antigen INHIBITOR SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Multidrug resistance protein 1 Transporter WOMBAT-PK
Canalicular multispecific organic anion transporter 1 Transporter WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter WOMBAT-PK
Multidrug resistance-associated protein 7 Transporter WOMBAT-PK
Tubulin Structural IC50 5.74 CHEMBL

External reference:

IDSource
4019971 VUID
N0000148056 NUI
D02197 KEGG_DRUG
2068-78-2 SECONDARY_CAS_RN
4017542 VANDF
4019971 VANDF
C0042679 UMLSCUI
CHEBI:28445 CHEBI
R1Q PDB_CHEM_ID
CHEMBL90555 ChEMBL_ID
CHEMBL501867 ChEMBL_ID
D014750 MESH_DESCRIPTOR_UI
DB00541 DRUGBANK_ID
6785 IUPHAR_LIGAND_ID
1440 INN_ID
5J49Q6B70F UNII
5978 PUBCHEM_CID
11202 RXNORM
5133 MMSL
5675 MMSL
7308 MMSL
879 MMSL
d00401 MMSL
002656 NDDF
004894 NDDF
23079006 SNOMEDCT_US
387126006 SNOMEDCT_US
387427007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Vincasar PFS HUMAN PRESCRIPTION DRUG LABEL 1 0703-4402 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 20 sections
Vincasar PFS HUMAN PRESCRIPTION DRUG LABEL 1 0703-4412 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 20 sections
VinCRIStine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 61703-309 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 22 sections
VinCRIStine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 61703-309 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 22 sections
VinCRIStine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 61703-309 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 22 sections
VinCRIStine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 61703-309 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 22 sections
VinCRIStine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 61703-309 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 22 sections
VinCRIStine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 61703-309 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 22 sections