vincristine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
vinca alkaloids 2825 57-22-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vincristine
  • (+)-Vincristine
  • leucristine
  • vincristin
  • vinkristin
  • 22-oxo-vincaleukoblastine
  • vincristine sulfate
  • oncovin
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
  • Molecular weight: 824.97
  • Formula: C46H56N4O10
  • CLOGP: 3.07
  • LIPINSKI: 2
  • HAC: 14
  • HDO: 3
  • TPSA: 171.17
  • ALOGS: -4.44
  • ROTB: 10
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 15 % Benet LZ, Broccatelli F, Oprea TI
Vd (Volume of distribution) 2.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.40 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 23 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 10, 1963 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 3695.73 15.18 1932 56576 95735 50450881
Neutropenia 1357.27 15.18 1220 57288 146745 50399871
Febrile bone marrow aplasia 808.09 15.18 296 58212 6015 50540601
Haematotoxicity 736.66 15.18 294 58214 7601 50539015
Product use in unapproved indication 717.83 15.18 772 57736 115047 50431569
Pancytopenia 571.69 15.18 589 57919 83441 50463175
Diffuse large B-cell lymphoma recurrent 551.71 15.18 159 58349 1436 50545180
Bone marrow failure 542.46 15.18 359 58149 27265 50519351
Second primary malignancy 501.14 15.18 215 58293 6699 50539917
Myelodysplastic syndrome 454.28 15.18 258 58250 14874 50531742
Venoocclusive liver disease 444.26 15.18 172 58336 4089 50542527
Thrombocytopenia 441.14 15.18 635 57873 127038 50419578
Mucosal inflammation 435.04 15.18 365 58143 39777 50506839
Acute myeloid leukaemia 433.74 15.18 250 58258 14824 50531792
Sepsis 396.14 15.18 617 57891 132308 50414308
Tumour lysis syndrome 382.77 15.18 182 58326 7239 50539377
Septic shock 381.75 15.18 397 58111 56778 50489838
Posterior reversible encephalopathy syndrome 367.80 15.18 224 58284 14704 50531912
Hypofibrinogenaemia 349.87 15.18 103 58405 1009 50545607
Myelosuppression 313.07 15.18 195 58313 13322 50533294
Pain 307.99 15.18 143 58365 578760 49967856
Off label use 304.44 15.18 1216 57292 473210 50073406
Ovarian failure 298.06 15.18 91 58417 1020 50545596
Acute lymphocytic leukaemia recurrent 291.70 15.18 103 58405 1872 50544744
Disease progression 270.14 15.18 434 58074 95432 50451184
Pyrexia 268.40 15.18 1005 57503 379198 50167418
Neurotoxicity 261.58 15.18 180 58328 14560 50532056
Staphylococcal bacteraemia 243.55 15.18 117 58391 4760 50541856
Multiple organ dysfunction syndrome 240.88 15.18 294 58214 50043 50496573
Disease recurrence 234.97 15.18 191 58317 19890 50526726
Diffuse large B-cell lymphoma refractory 231.69 15.18 74 58434 972 50545644
Joint swelling 231.15 15.18 13 58495 245273 50301343
Hepatitis B reactivation 230.97 15.18 88 58420 1999 50544617
Cardiotoxicity 222.19 15.18 124 58384 6903 50539713
Rheumatoid arthritis 218.57 15.18 3 58505 202547 50344069
Neutropenic sepsis 216.87 15.18 158 58350 13989 50532627
Neuropathy peripheral 210.83 15.18 391 58117 96366 50450250
Haemophagocytic lymphohistiocytosis 206.12 15.18 127 58381 8506 50538110
Neutropenic colitis 204.72 15.18 84 58424 2333 50544283
Neoplasm progression 199.03 15.18 205 58303 28952 50517664
Leukopenia 194.62 15.18 309 58199 67219 50479397
Drug resistance 193.98 15.18 167 58341 18822 50527794
Pruritus 190.24 15.18 47 58461 283521 50263095
Abdominal discomfort 188.87 15.18 23 58485 231618 50314998
Maternal exposure before pregnancy 183.07 15.18 101 58407 5496 50541120
Aplasia 182.92 15.18 89 58419 3724 50542892
Neutrophil count decreased 173.52 15.18 239 58269 45787 50500829
Fall 172.61 15.18 86 58422 334846 50211770
Cytopenia 172.02 15.18 114 58394 8661 50537955
Product dose omission issue 169.32 15.18 11 58497 183827 50362789
Nasopharyngitis 165.27 15.18 16 58492 192911 50353705
Post transplant lymphoproliferative disorder 160.29 15.18 84 58424 4120 50542496
Arthralgia 159.06 15.18 164 58344 438538 50108078
Hyperbilirubinaemia 158.40 15.18 112 58396 9458 50537158
Arthropathy 156.34 15.18 6 58502 157900 50388716
Hepatitis B 154.64 15.18 77 58431 3389 50543227
Epstein-Barr virus infection 154.61 15.18 98 58410 6899 50539717
Progressive multifocal leukoencephalopathy 153.40 15.18 118 58390 11339 50535277
Platelet count decreased 152.07 15.18 350 58158 100376 50446240
B-cell lymphoma recurrent 152.05 15.18 43 58465 360 50546256
Systemic lupus erythematosus 147.82 15.18 3 58505 140619 50405997
Swelling 147.50 15.18 27 58481 200845 50345771
Contraindicated product administered 146.32 15.18 6 58502 148952 50397664
Fatigue 146.06 15.18 383 58125 707218 49839398
Peripheral swelling 144.27 15.18 31 58477 205905 50340711
Weight increased 142.23 15.18 30 58478 201861 50344755
Neoplasm recurrence 137.31 15.18 63 58445 2306 50544310
Rash 135.61 15.18 185 58323 437286 50109330
Pneumatosis intestinalis 134.81 15.18 60 58448 2043 50544573
Cardiomyopathy 133.29 15.18 124 58384 15462 50531154
Hypertriglyceridaemia 131.64 15.18 81 58427 5410 50541206
Headache 129.01 15.18 244 58264 506291 50040325
Synovitis 128.78 15.18 3 58505 123862 50422754
Therapy partial responder 127.68 15.18 85 58423 6506 50540110
Dizziness 125.96 15.18 129 58379 346240 50200376
Anaemia 120.01 15.18 593 57915 251863 50294753
Diffuse large B-cell lymphoma 119.39 15.18 77 58431 5585 50541031
Blood culture positive 114.76 15.18 68 58440 4240 50542376
Malignant neoplasm progression 114.31 15.18 247 58261 67877 50478739
Secondary immunodeficiency 113.41 15.18 45 58463 1143 50545473
Ileus paralytic 110.70 15.18 65 58443 3985 50542631
Bacteraemia 110.45 15.18 108 58400 14325 50532291
Drug hypersensitivity 110.11 15.18 78 58430 250932 50295684
Musculoskeletal stiffness 109.08 15.18 11 58497 128470 50418146
Mucormycosis 107.35 15.18 54 58454 2429 50544187
Anxiety 106.91 15.18 36 58472 177570 50369046
Hypogammaglobulinaemia 106.80 15.18 72 58436 5627 50540989
Bone pain 106.71 15.18 194 58314 47035 50499581
Lennox-Gastaut syndrome 106.52 15.18 30 58478 247 50546369
Feeling abnormal 105.87 15.18 11 58497 125481 50421135
Pneumocystis jirovecii pneumonia 105.32 15.18 106 58402 14557 50532059
Malaise 104.75 15.18 141 58367 335391 50211225
Insomnia 104.29 15.18 36 58472 174829 50371787
Systemic candida 104.24 15.18 55 58453 2735 50543881
Injection site pain 104.11 15.18 6 58502 111018 50435598
Drug intolerance 102.97 15.18 63 58445 219041 50327575
Wound 101.45 15.18 5 58503 105789 50440827
Hepatocellular injury 101.18 15.18 137 58371 25810 50520806
Sinusitis 100.19 15.18 36 58472 170522 50376094
Therapeutic product effect decreased 98.30 15.18 19 58489 136031 50410585
Blood pressure increased 95.33 15.18 19 58489 133113 50413503
Dyspnoea 94.93 15.18 321 58187 547287 49999329
Smooth muscle cell neoplasm 94.36 15.18 35 58473 736 50545880
Discomfort 92.72 15.18 9 58499 108371 50438245
Acute lymphocytic leukaemia 91.82 15.18 47 58461 2194 50544422
Polyneuropathy 91.38 15.18 90 58418 12041 50534575
Klebsiella infection 89.60 15.18 71 58437 7123 50539493
Temporal lobe epilepsy 89.51 15.18 28 58480 342 50546274
Lymphopenia 89.26 15.18 100 58408 15521 50531095
Leukoencephalopathy 87.32 15.18 55 58453 3828 50542788
Clostridium difficile colitis 87.03 15.18 105 58403 17637 50528979
Respiratory failure 86.77 15.18 267 58241 90914 50455702
Disseminated intravascular coagulation 86.67 15.18 103 58405 17032 50529584
Escherichia bacteraemia 85.14 15.18 50 58458 3066 50543550
Ascites 83.16 15.18 149 58359 35712 50510904
Blood lactate dehydrogenase increased 81.97 15.18 107 58401 19455 50527161
Peripheral motor neuropathy 79.64 15.18 37 58471 1394 50545222
Superior sagittal sinus thrombosis 78.91 15.18 30 58478 677 50545939
Enterococcal infection 77.29 15.18 64 58444 6834 50539782
Pain in extremity 76.94 15.18 123 58385 272742 50273874
Colitis 76.76 15.18 150 58358 38379 50508237
Contusion 76.26 15.18 18 58490 112165 50434451
Ejection fraction decreased 75.59 15.18 100 58408 18420 50528196
Venoocclusive disease 75.47 15.18 39 58469 1857 50544759
Arthritis 74.71 15.18 7 58501 86714 50459902
Rhinovirus infection 74.36 15.18 48 58460 3486 50543130
Asthma 72.40 15.18 9 58499 89328 50457288
Urticaria 71.68 15.18 30 58478 129531 50417085
Lymphadenopathy 71.13 15.18 134 58374 33365 50513251
Cervix disorder 70.86 15.18 25 58483 453 50546163
Bronchopulmonary aspergillosis 69.97 15.18 63 58445 7529 50539087
Overdose 69.80 15.18 15 58493 99712 50446904
Peripheral sensory neuropathy 69.40 15.18 59 58449 6532 50540084
Gene mutation 68.06 15.18 32 58476 1239 50545377
Herpes simplex 67.13 15.18 60 58448 7102 50539514
Myelopathy 67.11 15.18 40 58468 2521 50544095
Pseudomonas test positive 66.36 15.18 26 58482 638 50545978
Aspergillus infection 65.64 15.18 58 58450 6763 50539853
Hypersensitivity 65.46 15.18 92 58416 215069 50331547
Cystitis haemorrhagic 65.17 15.18 45 58463 3657 50542959
Cytokine release syndrome 64.92 15.18 64 58444 8570 50538046
White blood cell count decreased 64.71 15.18 287 58221 116435 50430181
Alopecia 63.08 15.18 117 58391 244930 50301686
Fungaemia 62.22 15.18 35 58473 1977 50544639
Injection site erythema 62.08 15.18 7 58501 74929 50471687
Muscle spasms 61.92 15.18 34 58474 125519 50421097
Cerebral venous thrombosis 61.83 15.18 34 58474 1837 50544779
Quadriplegia 61.64 15.18 33 58475 1690 50544926
Bronchitis 61.11 15.18 22 58486 104137 50442479
Hepatic enzyme increased 61.08 15.18 42 58466 137338 50409278
Human bocavirus infection 60.87 15.18 21 58487 355 50546261
Cerebral venous sinus thrombosis 59.82 15.18 32 58476 1636 50544980
Leukaemia recurrent 59.34 15.18 29 58479 1225 50545391
Enterococcal bacteraemia 59.25 15.18 29 58479 1229 50545387
Pneumocystis jirovecii infection 58.88 15.18 29 58479 1246 50545370
Inappropriate schedule of product administration 58.78 15.18 7 58501 71824 50474792
Pleural effusion 58.44 15.18 217 58291 81237 50465379
Drug ineffective 57.54 15.18 639 57869 818694 49727922
Agranulocytosis 57.53 15.18 95 58413 21326 50525290
Congestive cardiomyopathy 57.29 15.18 49 58459 5469 50541147
Hospitalisation 57.16 15.18 6 58502 67931 50478685
Enterovirus test positive 57.11 15.18 16 58492 129 50546487
Central nervous system lymphoma 57.00 15.18 29 58479 1336 50545280
Epstein-Barr virus associated lymphoproliferative disorder 56.67 15.18 31 58477 1658 50544958
Cardiac failure 56.59 15.18 205 58303 75835 50470781
Human herpesvirus 6 infection 56.32 15.18 36 58472 2570 50544046
Respiratory distress 56.29 15.18 115 58393 30374 50516242
Lymphoma transformation 56.26 15.18 16 58492 137 50546479
Ototoxicity 56.15 15.18 27 58481 1100 50545516
Myeloid leukaemia 55.75 15.18 19 58489 309 50546307
Hepatic failure 55.20 15.18 118 58390 32165 50514451
Glioma 53.55 15.18 18 58490 280 50546336
Pyomyositis 53.46 15.18 19 58489 352 50546264
Enterobacter infection 53.44 15.18 31 58477 1857 50544759
Chest pain 53.42 15.18 76 58432 176806 50369810
Migraine 53.33 15.18 11 58497 75269 50471347
Device related infection 53.07 15.18 90 58418 20645 50525971
Abdominal pain upper 52.66 15.18 64 58444 159245 50387371
Palpitations 52.07 15.18 22 58486 94484 50452132
JC virus infection 51.91 15.18 30 58478 1785 50544831
Refractory anaemia with an excess of blasts 51.65 15.18 19 58489 390 50546226
Venous thrombosis 51.21 15.18 42 58466 4424 50542192
Vocal cord paralysis 51.01 15.18 29 58479 1672 50544944
Pericarditis 50.83 15.18 14 58494 78675 50467941
Human rhinovirus test positive 50.57 15.18 15 58493 151 50546465
Loss of personal independence in daily activities 50.12 15.18 10 58498 70040 50476576
Antithrombin III decreased 49.96 15.18 16 58492 212 50546404
Perineal necrosis 49.95 15.18 14 58494 113 50546503
Impaired healing 49.85 15.18 10 58498 69776 50476840
Blood fibrinogen decreased 49.66 15.18 21 58487 630 50545986
Epstein-Barr virus associated lymphoma 49.12 15.18 19 58489 450 50546166
Depression 49.04 15.18 72 58436 165351 50381265
Staphylococcal sepsis 48.94 15.18 50 58458 6986 50539630
Perineal infection 48.90 15.18 14 58494 123 50546493
Heart rate abnormal 48.86 15.18 39 58469 3953 50542663
Cutaneous calcification 48.77 15.18 13 58495 85 50546531
Diarrhoea 47.78 15.18 443 58065 588033 49958583
Cytomegalovirus infection 47.35 15.18 79 58429 17883 50528733
Hyperpyrexia 46.59 15.18 34 58474 3015 50543601
Left ventricular dysfunction 46.41 15.18 59 58449 10447 50536169
Candida infection 46.14 15.18 91 58417 23432 50523184
Injection site reaction 45.99 15.18 3 58505 50029 50496587
Hepatotoxicity 45.96 15.18 99 58409 27127 50519489
Premature menopause 45.76 15.18 21 58487 769 50545847
Philadelphia chromosome positive 45.63 15.18 17 58491 362 50546254
Mantle cell lymphoma recurrent 45.53 15.18 13 58495 113 50546503
Hepatitis E 45.27 15.18 24 58484 1205 50545411
Encephalopathy 45.24 15.18 112 58396 33599 50513017
Osteoarthritis 44.70 15.18 12 58496 68594 50478022
B-cell lymphoma refractory 44.56 15.18 12 58496 82 50546534
Mucosal toxicity 44.55 15.18 16 58492 306 50546310
Ileus 44.36 15.18 65 58443 13164 50533452
Acute hepatitis B 43.93 15.18 16 58492 319 50546297
Osteomyelitis bacterial 43.89 15.18 14 58494 183 50546433
Blister 43.77 15.18 22 58486 85396 50461220
Stomatitis 43.76 15.18 232 58276 101112 50445504
Hepatomegaly 43.61 15.18 58 58450 10735 50535881
Bacterial sepsis 43.59 15.18 35 58473 3577 50543039
Bacterial infection 43.44 15.18 72 58436 16209 50530407
Neck pain 43.31 15.18 7 58501 57060 50489556
Fusarium infection 42.81 15.18 18 58490 532 50546084
Hyperglycaemia 42.72 15.18 115 58393 36290 50510326
B precursor type acute leukaemia 42.71 15.18 13 58495 144 50546472
5q minus syndrome 42.62 15.18 14 58494 202 50546414
Nausea 42.61 15.18 568 57940 704830 49841786
Gastroenteritis norovirus 42.46 15.18 26 58482 1721 50544895
Combined immunodeficiency 42.27 15.18 12 58496 102 50546514
Herpes zoster meningoencephalitis 42.15 15.18 15 58493 279 50546337
Babesiosis 41.82 15.18 14 58494 215 50546401
Platelet count abnormal 41.80 15.18 31 58477 2818 50543798
Condition aggravated 41.77 15.18 189 58319 296869 50249747
Influenza like illness 41.53 15.18 8 58500 57451 50489165
Clostridium test positive 40.80 15.18 27 58481 2045 50544571
Humoral immune defect 40.74 15.18 11 58497 76 50546540
Gastrosplenic fistula 40.64 15.18 10 58498 45 50546571
Mobility decreased 40.36 15.18 21 58487 79927 50466689
Transverse sinus thrombosis 40.29 15.18 17 58491 507 50546109
Unmasking of previously unidentified disease 39.86 15.18 19 58489 759 50545857
Lower respiratory tract infection 39.84 15.18 31 58477 95170 50451446
Intussusception 39.65 15.18 16 58492 425 50546191
Intentional product misuse 39.64 15.18 4 58504 46730 50499886
Pulmonary haemorrhage 39.57 15.18 43 58465 6449 50540167
Injury 39.46 15.18 5 58503 48920 50497696
Lymphadenitis 39.15 15.18 29 58479 2631 50543985
Cholestasis 39.08 15.18 89 58419 25312 50521304
Clostridium difficile infection 38.99 15.18 89 58419 25350 50521266
Haemorrhage intracranial 38.92 15.18 59 58449 12315 50534301
Erythropoiesis abnormal 38.92 15.18 14 58494 269 50546347
Infusion related reaction 38.46 15.18 87 58421 169470 50377146
Hypoalbuminaemia 38.33 15.18 52 58456 9808 50536808
Histiocytic sarcoma 38.11 15.18 10 58498 61 50546555
Leukoerythroblastosis 37.40 15.18 13 58495 225 50546391
Myocardial infarction 37.24 15.18 29 58479 88998 50457618
Injection site swelling 36.98 15.18 3 58505 41770 50504846
Infection 36.95 15.18 333 58175 172621 50373995
Cerebrovascular accident 36.95 15.18 33 58475 94647 50451969
Jugular vein thrombosis 36.59 15.18 28 58480 2668 50543948
Wheezing 36.56 15.18 13 58495 62034 50484582
Therapy responder 36.41 15.18 14 58494 326 50546290
Nail pigmentation 36.35 15.18 12 58496 176 50546440
Varicella zoster virus infection 36.33 15.18 27 58481 2462 50544154
Tissue infiltration 36.16 15.18 16 58492 537 50546079
Duodenal ulcer perforation 35.97 15.18 5 58503 45606 50501010
Therapeutic response delayed 35.94 15.18 16 58492 545 50546071
Back pain 35.92 15.18 132 58376 219898 50326718
Malignant transformation 35.79 15.18 14 58494 342 50546274
Leukaemic lymphoma 35.76 15.18 10 58498 80 50546536
Infection reactivation 35.58 15.18 19 58489 968 50545648
Cytomegalovirus viraemia 35.58 15.18 35 58473 4674 50541942
Cardiomyopathy acute 35.57 15.18 12 58496 189 50546427
Injection site pruritus 35.50 15.18 3 58505 40408 50506208
Premature delivery 35.40 15.18 82 58426 23581 50523035
Rhinocerebral mucormycosis 35.22 15.18 12 58496 195 50546421
Bone marrow disorder 35.04 15.18 24 58484 1924 50544692
Inappropriate antidiuretic hormone secretion 34.90 15.18 58 58450 13085 50533531
Toxic neuropathy 34.83 15.18 14 58494 368 50546248
Glioblastoma multiforme 34.72 15.18 17 58491 721 50545895
Acute promyelocytic leukaemia 34.66 15.18 18 58490 866 50545750
Hot flush 34.47 15.18 5 58503 44164 50502452
Blood glucose increased 34.16 15.18 20 58488 71304 50475312
Ureaplasma infection 33.91 15.18 15 58493 503 50546113
Potentiating drug interaction 33.86 15.18 31 58477 3785 50542831
Suicidal ideation 33.68 15.18 11 58497 55374 50491242
Antithrombin III 33.66 15.18 11 58497 156 50546460
Aplastic anaemia 33.62 15.18 43 58465 7660 50538956
Adverse drug reaction 33.53 15.18 11 58497 55211 50491405
Confusional state 33.42 15.18 107 58401 185821 50360795
Salivary gland cancer 33.34 15.18 11 58497 161 50546455
Gastrointestinal necrosis 33.12 15.18 26 58482 2572 50544044
White blood cell count abnormal 33.10 15.18 36 58472 5404 50541212
Acute myelomonocytic leukaemia 32.97 15.18 11 58497 167 50546449
Lung infiltration 32.78 15.18 57 58451 13336 50533280
Necrotising gastritis 32.75 15.18 9 58499 67 50546549
Oedema peripheral 32.70 15.18 85 58423 157876 50388740
Pneumonia fungal 32.44 15.18 32 58476 4288 50542328
Incorrect dose administered 32.43 15.18 8 58500 48406 50498210
Vision blurred 32.41 15.18 26 58482 78621 50467995
Cryptococcosis 31.75 15.18 17 58491 871 50545745
Listeria sepsis 31.68 15.18 15 58493 590 50546026
Feeling hot 31.63 15.18 4 58504 39198 50507418
Loss of consciousness 31.32 15.18 45 58463 104308 50442308
Trichodysplasia spinulosa 31.15 15.18 14 58494 488 50546128
Escherichia test positive 31.08 15.18 23 58485 2084 50544532
Pseudomonal sepsis 31.08 15.18 23 58485 2084 50544532
Dry mouth 31.06 15.18 13 58495 56165 50490451
Klebsiella bacteraemia 31.02 15.18 19 58489 1258 50545358
Growth hormone deficiency 30.85 15.18 10 58498 138 50546478
BK virus infection 30.76 15.18 26 58482 2855 50543761
Cerebellar stroke 30.74 15.18 11 58497 208 50546408
Basal ganglion degeneration 30.59 15.18 13 58495 395 50546221
Helicobacter infection 30.00 15.18 10 58498 49692 50496924
Acute biphenotypic leukaemia 29.92 15.18 8 58500 53 50546563
Pneumonia 29.84 15.18 608 57900 377793 50168823
Drug abuse 29.79 15.18 16 58492 59830 50486786
Pseudomonas infection 29.71 15.18 45 58463 9385 50537231
Burning sensation 29.50 15.18 8 58500 45438 50501178
Brain oedema 29.44 15.18 52 58456 12318 50534298
Subdural hygroma 29.41 15.18 11 58497 237 50546379
Paraparesis 29.26 15.18 22 58486 2042 50544574
Lymphoma 29.10 15.18 45 58463 9556 50537060
Staphylococcal infection 29.05 15.18 99 58409 35517 50511099
Hepatosplenic candidiasis 28.82 15.18 11 58497 251 50546365
Lymphoproliferative disorder 28.76 15.18 25 58483 2852 50543764
Capillary leak syndrome 28.71 15.18 21 58487 1869 50544747
Depressed mood 28.63 15.18 3 58505 34020 50512596
Blood cholesterol increased 28.62 15.18 14 58494 55201 50491415
Medulloblastoma recurrent 28.61 15.18 8 58500 64 50546552
Cytomegalovirus colitis 28.34 15.18 21 58487 1906 50544710
COVID-19 28.34 15.18 118 58390 46544 50500072
Memory impairment 28.25 15.18 30 58478 79330 50467286
Gastrooesophageal reflux disease 28.22 15.18 28 58480 76400 50470216
Pneumonia cytomegaloviral 28.21 15.18 21 58487 1920 50544696
Myalgia 28.01 15.18 64 58444 124255 50422361
Flushing 27.81 15.18 22 58486 66993 50479623
Chest discomfort 27.81 15.18 40 58468 92682 50453934
Pulse waveform abnormal 27.77 15.18 8 58500 72 50546544
Ankle brachial index decreased 27.68 15.18 8 58500 73 50546543
Hypertransaminasaemia 27.58 15.18 27 58481 3584 50543032
Streptococcus test positive 27.56 15.18 17 58491 1140 50545476
Carotid intima-media thickness increased 27.29 15.18 8 58500 77 50546539
Chronic myelomonocytic leukaemia 27.27 15.18 11 58497 292 50546324
Chronic hepatitis 27.03 15.18 15 58493 825 50545791
Haemolytic uraemic syndrome 26.99 15.18 22 58486 2297 50544319
Suicide attempt 26.99 15.18 13 58495 51719 50494897
Oesophageal candidiasis 26.88 15.18 31 58477 4963 50541653
Soft tissue infection 26.74 15.18 20 58488 1842 50544774
Seizure 26.73 15.18 230 58278 117644 50428972
Atypical haemolytic uraemic syndrome 26.71 15.18 13 58495 544 50546072
Primary immunodeficiency syndrome 26.63 15.18 7 58501 43 50546573
Somnolence 26.60 15.18 91 58417 154894 50391722
Hyperammonaemia 26.57 15.18 30 58478 4694 50541922
Heart rate decreased 26.54 15.18 5 58503 36492 50510124
Nephroblastoma 26.47 15.18 5 58503 3 50546613
Leukaemia 26.42 15.18 26 58482 3473 50543143
Leukaemia cutis 26.42 15.18 8 58500 87 50546529
Uterine enlargement 26.25 15.18 16 58492 1050 50545566
Sleep disorder 26.13 15.18 17 58491 57266 50489350
Tumour necrosis 26.10 15.18 14 58494 720 50545896
Escherichia infection 26.05 15.18 46 58462 10895 50535721
Hepatic infarction 25.88 15.18 13 58495 583 50546033
Partial seizures 25.85 15.18 30 58478 4835 50541781
Chronic kidney disease 25.82 15.18 7 58501 39764 50506852
Premature baby 25.75 15.18 62 58446 18275 50528341
Geotrichum infection 25.68 15.18 12 58496 458 50546158
Alveolar soft part sarcoma 25.48 15.18 8 58500 99 50546517
Femur fracture 25.47 15.18 6 58502 37458 50509158
Metastases to meninges 25.45 15.18 20 58488 1982 50544634
Hyperhidrosis 25.44 15.18 40 58468 89386 50457230
Rhabdomyosarcoma recurrent 25.37 15.18 6 58502 22 50546594
Osteonecrosis 25.29 15.18 70 58438 22447 50524169
Ill-defined disorder 25.23 15.18 16 58492 54638 50491978
Unevaluable event 24.93 15.18 11 58497 46055 50500561
Joint stiffness 24.68 15.18 3 58505 30305 50516311
Coagulopathy 24.48 15.18 60 58448 17884 50528732
Acquired gene mutation 24.47 15.18 14 58494 817 50545799
Gait disturbance 24.45 15.18 90 58418 149915 50396701
Acute lymphocytic leukaemia refractory 24.40 15.18 7 58501 62 50546554
Tachycardia 24.39 15.18 198 58310 99565 50447051
Respiratory arrest 24.36 15.18 3 58505 30006 50516610
Platelet transfusion 24.30 15.18 13 58495 665 50545951
Therapy non-responder 24.24 15.18 120 58388 50902 50495714
Tracheo-oesophageal fistula 24.22 15.18 12 58496 522 50546094
Stem cell transplant 24.14 15.18 18 58490 1650 50544966
Gastric stenosis 24.01 15.18 7 58501 66 50546550
Hallucination 23.92 15.18 12 58496 46645 50499971
Mediastinum neoplasm 23.92 15.18 7 58501 67 50546549
Pneumonia influenzal 23.88 15.18 17 58491 1450 50545166
Nasal congestion 23.55 15.18 15 58493 51105 50495511
Splenomegaly 23.50 15.18 41 58467 9619 50536997
Cytomegalovirus chorioretinitis 23.47 15.18 17 58491 1490 50545126
Blood immunoglobulin G decreased 23.46 15.18 19 58489 1966 50544650
Staphylococcus test positive 23.32 15.18 24 58484 3382 50543234
Recurrent cancer 23.30 15.18 18 58490 1739 50544877
Mucosal infection 23.20 15.18 8 58500 135 50546481
Lipase increased 23.09 15.18 38 58470 8503 50538113
Polyomavirus-associated nephropathy 23.02 15.18 17 58491 1535 50545081
Refractory cytopenia with multilineage dysplasia 22.93 15.18 8 58500 140 50546476
Cough 22.92 15.18 174 58334 241090 50305526
Musculoskeletal pain 22.78 15.18 30 58478 72147 50474469
Nephrolithiasis 22.72 15.18 6 58502 34687 50511929
Pharyngeal inflammation 22.68 15.18 12 58496 600 50546016
Coronavirus infection 22.56 15.18 22 58486 2907 50543709
International normalised ratio increased 22.27 15.18 11 58497 43141 50503475
Small intestinal obstruction 22.21 15.18 54 58454 16014 50530602
Anaesthesia 22.21 15.18 10 58498 350 50546266
Cardiac disorder 22.12 15.18 11 58497 42968 50503648
Jejunal stenosis 22.03 15.18 6 58502 43 50546573
Urinary tract infection 22.02 15.18 160 58348 223860 50322756
Intracardiac thrombus 21.84 15.18 19 58489 2170 50544446
Fluid retention 21.82 15.18 16 58492 50633 50495983
Gastric disorder 21.59 15.18 4 58504 29544 50517072
Blast cells present 21.59 15.18 10 58498 374 50546242
Peritonitis viral 21.46 15.18 6 58502 48 50546568
Haemoglobin abnormal 21.45 15.18 26 58482 4386 50542230
Peripheral sensorimotor neuropathy 21.41 15.18 15 58493 1247 50545369
Epstein Barr virus positive mucocutaneous ulcer 21.32 15.18 10 58498 385 50546231
Retinal pigment epitheliopathy 21.32 15.18 8 58500 174 50546442
Neurological decompensation 21.24 15.18 19 58489 2251 50544365
Hemiparesis 21.22 15.18 61 58447 19987 50526629
Dyspepsia 21.21 15.18 33 58475 74064 50472552
Papillary thyroid cancer 21.14 15.18 18 58490 1997 50544619
Adenovirus infection 21.11 15.18 22 58486 3146 50543470
Urinary tract infection bacterial 21.02 15.18 25 58483 4134 50542482
Chronic hepatitis B 21.02 15.18 8 58500 181 50546435
Abdominal neoplasm 20.98 15.18 9 58499 280 50546336
Sinusitis fungal 20.95 15.18 15 58493 1291 50545325
Ocular lymphoma 20.93 15.18 6 58502 53 50546563
Iris atrophy 20.83 15.18 6 58502 54 50546562
Brain injury 20.82 15.18 30 58478 5984 50540632
Balance disorder 20.63 15.18 31 58477 70559 50476057
Erythema 20.63 15.18 93 58415 146321 50400295
Paranasal sinus mucosal hypertrophy 20.60 15.18 5 58503 21 50546595
Central nervous system enteroviral infection 20.41 15.18 5 58503 22 50546594
B-cell lymphoma 20.38 15.18 21 58487 2964 50543652
Vulvovaginitis 20.23 15.18 9 58499 306 50546310
Rhinorrhoea 20.09 15.18 18 58490 51565 50495051
Vulvovaginal inflammation 20.06 15.18 11 58497 591 50546025
Renal replacement therapy 20.00 15.18 6 58502 63 50546553
Primary mediastinal large B-cell lymphoma recurrent 19.92 15.18 6 58502 64 50546552
Intestinal perforation 19.90 15.18 40 58468 10439 50536177
Inflammatory myofibroblastic tumour 19.89 15.18 5 58503 25 50546591
B-cell type acute leukaemia 19.88 15.18 7 58501 126 50546490
Myeloproliferative neoplasm 19.75 15.18 10 58498 456 50546160
Subacute combined cord degeneration 19.53 15.18 8 58500 221 50546395
Metastases to peritoneum 19.46 15.18 20 58488 2813 50543803
Blood bilirubin increased 19.43 15.18 81 58427 31957 50514659
Blood magnesium decreased 19.31 15.18 41 58467 11119 50535497
Cytogenetic abnormality 19.30 15.18 10 58498 479 50546137
Restlessness 19.29 15.18 3 58505 25170 50521446
Hypoaesthesia 19.04 15.18 79 58429 127178 50419438
Cataract 19.04 15.18 16 58492 47284 50499332
Product quality issue 18.99 15.18 6 58502 30852 50515764
Blood immunoglobulin A decreased 18.99 15.18 9 58499 355 50546261
Visual impairment 18.98 15.18 31 58477 68244 50478372
Encephalitis 18.84 15.18 32 58476 7348 50539268
Blood stem cell transplant failure 18.71 15.18 7 58501 151 50546465
Retinoblastoma 18.70 15.18 6 58502 80 50546536
Emotional distress 18.69 15.18 5 58503 28658 50517958
Amnesia 18.66 15.18 13 58495 42247 50504369
Adverse event 18.62 15.18 14 58494 43749 50502867
Rectal fissure 18.61 15.18 10 58498 516 50546100
Hereditary motor and sensory neuropathy 18.50 15.18 6 58502 83 50546533
Limb discomfort 18.45 15.18 3 58505 24354 50522262
Listeria encephalitis 18.44 15.18 8 58500 256 50546360
Blood pressure systolic increased 18.35 15.18 9 58499 35440 50511176
Tooth disorder 18.32 15.18 3 58505 24225 50522391
SARS-CoV-2 test negative 18.27 15.18 9 58499 387 50546229
Urethritis 18.26 15.18 8 58500 262 50546354
Parainfluenzae virus infection 18.15 15.18 16 58492 1859 50544757
Splenic necrosis 18.10 15.18 5 58503 38 50546578
Head injury 18.10 15.18 3 58505 24017 50522599
Weight decreased 18.09 15.18 166 58342 221079 50325537
Klebsiella test positive 18.01 15.18 12 58496 919 50545697
Enteral nutrition 17.88 15.18 5 58503 40 50546576
Bacillus test positive 17.88 15.18 5 58503 40 50546576
Liver function test abnormal 17.84 15.18 15 58493 44324 50502292
Postictal state 17.79 15.18 12 58496 938 50545678
Flagellate dermatitis 17.78 15.18 7 58501 174 50546442
Asthenia 17.68 15.18 261 58247 318781 50227835
Flatulence 17.65 15.18 6 58502 29452 50517164
Gastrointestinal inflammation 17.49 15.18 24 58484 4576 50542040
Localised infection 17.48 15.18 4 58504 25481 50521135
Skin discolouration 17.44 15.18 8 58500 32749 50513867
Angioedema 17.43 15.18 11 58497 37665 50508951
Aborted pregnancy 17.36 15.18 5 58503 45 50546571
Quadriparesis 17.33 15.18 15 58493 1701 50544915
Haemangioma-thrombocytopenia syndrome 17.29 15.18 3 58505 0 50546616
Mantle cell lymphoma 17.25 15.18 9 58499 437 50546179
Rhabdomyolysis 17.24 15.18 12 58496 39015 50507601
Endocarditis 16.99 15.18 25 58483 5082 50541534
Pseudomonal bacteraemia 16.92 15.18 13 58495 1246 50545370
T-cell lymphoma 16.87 15.18 10 58498 624 50545992
Swollen tongue 16.86 15.18 6 58502 28624 50517992
Dry eye 16.84 15.18 8 58500 32087 50514529
Encopresis 16.84 15.18 6 58502 112 50546504
Eczema 16.75 15.18 3 58505 22699 50523917
Hydrocephalus 16.74 15.18 24 58484 4764 50541852
Subclavian vein thrombosis 16.72 15.18 15 58493 1784 50544832
B-lymphocyte count abnormal 16.71 15.18 5 58503 52 50546564
Throat irritation 16.71 15.18 7 58501 30232 50516384
Hepatic cytolysis 16.68 15.18 32 58476 8071 50538545
IIIrd nerve paralysis 16.68 15.18 10 58498 637 50545979
Acute respiratory distress syndrome 16.64 15.18 58 58450 21041 50525575
Beta 2 microglobulin decreased 16.64 15.18 4 58504 16 50546600
Vascular compression 16.55 15.18 6 58502 118 50546498
Haematocolpos 16.54 15.18 5 58503 54 50546562
Tachycardia induced cardiomyopathy 16.54 15.18 5 58503 54 50546562
Enterococcus test positive 16.46 15.18 12 58496 1062 50545554
Pyloric stenosis 16.43 15.18 8 58500 335 50546281
Duodenal stenosis 16.35 15.18 9 58499 487 50546129
Obliterative bronchiolitis 16.34 15.18 15 58493 1838 50544778
Neutropenic infection 16.33 15.18 12 58496 1075 50545541
Osteosarcoma 16.32 15.18 6 58502 123 50546493
Cardiac failure congestive 16.26 15.18 47 58461 84335 50462281
Areflexia 16.23 15.18 18 58490 2762 50543854
Perirectal abscess 16.22 15.18 11 58497 868 50545748
Encephalitis viral 16.21 15.18 14 58494 1583 50545033
Pulmonary vascular disorder 16.17 15.18 8 58500 347 50546269
Otitis media acute 16.16 15.18 11 58497 873 50545743
Cheyne-Stokes respiration 16.14 15.18 6 58502 127 50546489
Enteritis 16.12 15.18 29 58479 6966 50539650
Ear infection 16.07 15.18 5 58503 25965 50520651
Rash pruritic 16.03 15.18 19 58489 47827 50498789
Listeriosis 15.97 15.18 13 58495 1355 50545261
Lymphocytosis 15.96 15.18 16 58492 2186 50544430
Acidosis 15.91 15.18 36 58472 10191 50536425
Malignant neoplasm of orbit 15.91 15.18 4 58504 20 50546596
Metastases to pancreas 15.90 15.18 7 58501 232 50546384
COVID-19 pneumonia 15.89 15.18 32 58476 8363 50538253
Hepatitis acute 15.85 15.18 31 58477 7930 50538686
Intra-abdominal haemorrhage 15.85 15.18 16 58492 2204 50544412
Vaccination failure 15.82 15.18 8 58500 364 50546252
Joint injury 15.81 15.18 3 58505 21786 50524830
Campylobacter infection 15.78 15.18 10 58498 703 50545913
Microsporidia infection 15.76 15.18 7 58501 237 50546379
Anal ulcer 15.75 15.18 9 58499 524 50546092
Axonal neuropathy 15.72 15.18 11 58497 913 50545703
Gastrointestinal toxicity 15.71 15.18 23 58485 4654 50541962
Treatment failure 15.68 15.18 94 58414 137543 50409073
Nephropathy toxic 15.67 15.18 31 58477 7998 50538618
Escherichia sepsis 15.60 15.18 22 58486 4302 50542314
Plasmodium falciparum infection 15.59 15.18 4 58504 22 50546594
Respiratory syncytial virus infection 15.58 15.18 24 58484 5078 50541538
Tremor 15.58 15.18 74 58434 114829 50431787
Generalised tonic-clonic seizure 15.55 15.18 66 58442 26244 50520372
Pancreatic pseudocyst 15.55 15.18 9 58499 537 50546079
Cardiac dysfunction 15.45 15.18 14 58494 1687 50544929
Enterocutaneous fistula 15.42 15.18 12 58496 1172 50545444
Inguinal hernia 15.41 15.18 14 58494 1692 50544924
Metastasis 15.40 15.18 22 58486 4353 50542263
Sciatica 15.40 15.18 3 58505 21379 50525237
Angiocentric lymphoma 15.40 15.18 9 58499 547 50546069
Cytomegalovirus infection reactivation 15.30 15.18 17 58491 2614 50544002
Respiratory tract infection fungal 15.23 15.18 8 58500 394 50546222
Ventriculo-peritoneal shunt 15.22 15.18 3 58505 3 50546613
Antithrombin III deficiency 15.22 15.18 3 58505 3 50546613
Plasminogen decreased 15.22 15.18 3 58505 3 50546613

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 3891.35 13.93 2818 74518 109422 29387769
Neutropenia 1229.27 13.93 1611 75725 130100 29367091
Product use in unapproved indication 758.31 13.93 1030 76306 85845 29411346
Diffuse large B-cell lymphoma recurrent 555.73 13.93 221 77115 2376 29494815
Myelosuppression 549.16 13.93 362 76974 11865 29485326
Mucosal inflammation 546.47 13.93 534 76802 31061 29466130
Haematotoxicity 544.75 13.93 291 77045 6408 29490783
Second primary malignancy 544.50 13.93 291 77045 6414 29490777
Febrile bone marrow aplasia 503.16 13.93 285 77051 7066 29490125
Hepatitis B reactivation 480.02 13.93 212 77124 3017 29494174
Hepatitis B 475.88 13.93 249 77087 5248 29491943
Bone marrow failure 457.99 13.93 455 76881 26994 29470197
Venoocclusive liver disease 393.74 13.93 238 77098 6679 29490512
Myelodysplastic syndrome 389.28 13.93 343 76993 17451 29479740
Posterior reversible encephalopathy syndrome 377.11 13.93 255 77081 8721 29488470
Pancytopenia 376.83 13.93 733 76603 82435 29414756
Acute myeloid leukaemia 374.69 13.93 325 77011 16188 29481003
Tumour lysis syndrome 366.07 13.93 298 77038 13586 29483605
Off label use 357.11 13.93 1641 75695 299159 29198032
Hypofibrinogenaemia 350.20 13.93 136 77200 1365 29495826
Pyrexia 282.92 13.93 1488 75848 286134 29211057
Neoplasm progression 265.98 13.93 284 77052 18328 29478863
Cytopenia 246.03 13.93 205 77131 9654 29487537
Thrombocytopenia 246.01 13.93 843 76493 133980 29363211
Fall 245.52 13.93 79 77257 177099 29320092
Cytomegalovirus chorioretinitis 230.91 13.93 129 77207 3109 29494082
Disease progression 228.01 13.93 595 76741 81321 29415870
Sepsis 224.45 13.93 850 76486 141832 29355359
Progressive multifocal leukoencephalopathy 216.95 13.93 181 77155 8538 29488653
Diffuse large B-cell lymphoma refractory 213.17 13.93 83 77253 839 29496352
Neutrophil count decreased 209.31 13.93 394 76942 43173 29454018
Product dose omission issue 203.87 13.93 12 77324 96371 29400820
Leukopenia 195.31 13.93 440 76896 54763 29442428
Neuropathy peripheral 188.53 13.93 507 76829 70520 29426671
Acquired gene mutation 188.26 13.93 83 77253 1175 29496016
Septic shock 186 13.93 466 76870 62094 29435097
Hyperbilirubinaemia 182.51 13.93 210 77126 14724 29482467
Neutropenic sepsis 181.91 13.93 187 77149 11540 29485651
Pneumocystis jirovecii pneumonia 180.39 13.93 221 77115 16558 29480633
Death 178.28 13.93 395 76941 341689 29155502
Myocardial infarction 177.92 13.93 36 77300 110260 29386931
B-cell lymphoma recurrent 168.93 13.93 63 77273 560 29496631
Therapy partial responder 163.79 13.93 124 77212 5075 29492116
Hypertriglyceridaemia 163.22 13.93 144 77192 7331 29489860
Dizziness 161.48 13.93 155 77181 189529 29307662
Acute lymphocytic leukaemia recurrent 157.31 13.93 92 77244 2424 29494767
Arthralgia 155.26 13.93 86 77250 139531 29357660
Cardiotoxicity 153.56 13.93 115 77221 4629 29492562
Mantle cell lymphoma recurrent 148.46 13.93 54 77282 444 29496747
Fatigue 146.65 13.93 389 76947 316432 29180759
Aspergillus infection 136.42 13.93 153 77183 10428 29486763
Bacteraemia 135.04 13.93 189 77147 16134 29481057
Dyspnoea 134.52 13.93 424 76912 326308 29170883
Neoplasm recurrence 133.48 13.93 76 77260 1901 29495290
Rash 132.41 13.93 182 77154 189637 29307554
Hypogammaglobulinaemia 131.38 13.93 115 77221 5792 29491399
Muscle spasms 129.22 13.93 11 77325 65071 29432120
Post transplant lymphoproliferative disorder 128.36 13.93 110 77226 5383 29491808
Rhabdomyolysis 124.31 13.93 9 77327 60799 29436392
Lymphadenopathy 120.80 13.93 227 77109 24822 29472369
Candida infection 118.15 13.93 171 77165 15054 29482137
Insomnia 115.16 13.93 44 77292 88717 29408474
Pain 114.93 13.93 169 77167 171263 29325928
Polyneuropathy 114.65 13.93 150 77186 12002 29485189
Pruritus 113.40 13.93 84 77252 116765 29380426
Anxiety 111.28 13.93 42 77294 85323 29411868
Drug resistance 108.63 13.93 199 77137 21341 29475850
Disease recurrence 108.17 13.93 168 77168 15746 29481445
Peripheral swelling 106.56 13.93 19 77317 63720 29433471
Lymphopenia 105.02 13.93 152 77184 13381 29483810
Leukoencephalopathy 103.78 13.93 83 77253 3684 29493507
Malaise 103.42 13.93 161 77175 159441 29337750
Cytokine release syndrome 101.29 13.93 147 77189 12972 29484219
Stomatitis 97.42 13.93 264 77072 36849 29460342
Venoocclusive disease 96.87 13.93 68 77268 2471 29494720
Myelopathy 94.83 13.93 61 77275 1913 29495278
Diffuse large B-cell lymphoma 93.58 13.93 98 77238 6178 29491013
Overdose 93.33 13.93 46 77290 79773 29417418
White blood cell count decreased 93.05 13.93 448 76888 82914 29414277
Malignant neoplasm progression 89.82 13.93 407 76929 73452 29423739
Depression 89.54 13.93 56 77280 85091 29412100
Neurotoxicity 89.34 13.93 147 77189 14466 29482725
Epstein-Barr virus infection 89.14 13.93 98 77238 6531 29490660
Weight increased 88.41 13.93 45 77291 76622 29420569
Myalgia 87.53 13.93 42 77294 73977 29423214
Herpes simplex 86.94 13.93 84 77252 4806 29492385
Acute lymphocytic leukaemia 85.64 13.93 64 77272 2567 29494624
Somnolence 81.88 13.93 75 77261 93880 29403311
Confusional state 81.84 13.93 130 77206 127747 29369444
Inappropriate schedule of product administration 81.83 13.93 10 77326 44462 29452729
Hospitalisation 80.68 13.93 12 77324 45976 29451215
Feeling abnormal 79.38 13.93 22 77314 54423 29442768
Coronary artery disease 78.76 13.93 11 77325 44179 29453012
Blood fibrinogen decreased 77.76 13.93 41 77295 877 29496314
Suicidal ideation 77.60 13.93 3 77333 34713 29462478
Hepatic failure 77.59 13.93 219 77117 31293 29465898
Cytomegalovirus infection 76.44 13.93 180 77156 23035 29474156
Fungal infection 76.14 13.93 132 77204 13553 29483638
Cerebrovascular accident 73.66 13.93 56 77280 76855 29420336
Blood pressure increased 72.93 13.93 52 77284 73751 29423440
Rheumatoid arthritis 71.12 13.93 3 77333 32149 29465042
Multiple organ dysfunction syndrome 70.97 13.93 340 76996 62776 29434415
Sweat gland tumour 70.88 13.93 30 77306 382 29496809
Chest pain 70.53 13.93 115 77221 111858 29385333
Cardiac failure congestive 70.52 13.93 58 77278 76523 29420668
Diarrhoea 69.38 13.93 548 76788 332150 29165041
Chronic obstructive pulmonary disease 68.89 13.93 12 77324 40943 29456248
Haemophagocytic lymphohistiocytosis 68.75 13.93 109 77227 10395 29486796
Intentional product misuse 68.39 13.93 6 77330 34655 29462536
Neutropenic colitis 68.30 13.93 54 77282 2357 29494834
Cerebral venous thrombosis 67.17 13.93 33 77303 605 29496586
West Nile viral infection 66.59 13.93 33 77303 617 29496574
Drug interaction 66.50 13.93 278 77058 197107 29300084
Oedema peripheral 66.50 13.93 105 77231 103452 29393739
Bronchopulmonary aspergillosis 65.99 13.93 117 77219 12227 29484964
Blood glucose increased 65.95 13.93 36 77300 58948 29438243
Aplasia 65.19 13.93 66 77270 3997 29493194
Nasopharyngitis 64.44 13.93 38 77298 59627 29437564
Hyperhidrosis 64.38 13.93 45 77291 64495 29432696
Blood creatine phosphokinase increased 63.96 13.93 14 77322 40630 29456561
Osteonecrosis 63.28 13.93 121 77215 13398 29483793
Colitis 62.63 13.93 202 77134 31046 29466145
Back pain 62.61 13.93 107 77229 102177 29395014
Enterovirus infection 62.40 13.93 32 77304 645 29496546
Coombs positive haemolytic anaemia 62.04 13.93 33 77303 719 29496472
Cerebral venous sinus thrombosis 61.70 13.93 27 77309 375 29496816
Hallucination 61.67 13.93 20 77316 44692 29452499
Malignant transformation 61.57 13.93 34 77302 800 29496391
Systemic mycosis 61.43 13.93 40 77296 1281 29495910
Tremor 61.37 13.93 61 77275 73477 29423714
Pain in extremity 60.98 13.93 123 77213 110310 29386881
End stage renal disease 60.80 13.93 87 77249 7577 29489614
Aggression 60.69 13.93 10 77326 35531 29461660
Injection site pain 60.42 13.93 7 77329 32439 29464752
Multiple-drug resistance 60.12 13.93 62 77274 3838 29493353
Hepatotoxicity 59.32 13.93 139 77197 17728 29479463
Memory impairment 58.54 13.93 12 77324 36458 29460733
Ileus paralytic 58.07 13.93 70 77266 5153 29492038
Escherichia sepsis 55.92 13.93 60 77276 3889 29493302
Minimal residual disease 55.78 13.93 24 77312 319 29496872
Blood culture positive 55.29 13.93 64 77272 4513 29492678
Adenovirus infection 55.09 13.93 63 77273 4384 29492807
JC virus infection 54.84 13.93 43 77293 1854 29495337
Anaemia 54.79 13.93 782 76554 200169 29297022
Incorrect dose administered 54.74 13.93 10 77326 32974 29464217
Asthma 54.62 13.93 11 77325 33838 29463353
Chest discomfort 54.48 13.93 26 77310 45957 29451234
Plasma cell myeloma 54.09 13.93 15 77321 37100 29460091
Mucormycosis 53.90 13.93 67 77269 5091 29492100
Acute lymphocytic leukaemia refractory 53.74 13.93 17 77319 86 29497105
Infection reactivation 53.23 13.93 34 77302 1053 29496138
Suicide attempt 53.16 13.93 12 77324 34098 29463093
Musculoskeletal stiffness 53.00 13.93 16 77320 37442 29459749
Psoriasis 52.99 13.93 10 77326 32217 29464974
Gastritis bacterial 52.83 13.93 20 77316 186 29497005
Platelet count decreased 52.23 13.93 459 76877 104213 29392978
Loss of personal independence in daily activities 51.31 13.93 4 77332 25436 29471755
Viral haemorrhagic cystitis 50.04 13.93 31 77305 909 29496282
Staphylococcal sepsis 49.97 13.93 86 77250 8776 29488415
Strongyloidiasis 49.39 13.93 44 77292 2268 29494923
Cardiomyopathy 49.05 13.93 115 77221 14672 29482519
Bacterial sepsis 49.00 13.93 61 77275 4642 29492549
Syncope 48.98 13.93 86 77250 81285 29415906
Intussusception 48.61 13.93 25 77311 507 29496684
Gait disturbance 48.38 13.93 73 77263 73276 29423915
Antithrombin III decreased 48.16 13.93 21 77315 289 29496902
Lymphadenitis 47.70 13.93 37 77299 1570 29495621
Balance disorder 46.76 13.93 18 77318 36152 29461039
Headache 46.45 13.93 266 77070 173741 29323450
Coagulopathy 45.59 13.93 126 77210 17781 29479410
Glioma 45.49 13.93 20 77316 281 29496910
Clostridium difficile infection 44.53 13.93 117 77219 16024 29481167
Klebsiella infection 43.67 13.93 73 77263 7276 29489915
Pseudomonas infection 43.44 13.93 91 77245 10761 29486430
Encephalopathy 43.00 13.93 178 77158 30865 29466326
Device related infection 42.79 13.93 113 77223 15523 29481668
Systemic candida 42.50 13.93 44 77292 2736 29494455
Asthenia 42.24 13.93 360 76976 214890 29282301
Lymphoma transformation 41.60 13.93 16 77320 156 29497035
Escherichia bacteraemia 41.49 13.93 44 77292 2814 29494377
Loss of consciousness 41.27 13.93 82 77254 73974 29423217
Agranulocytosis 41.21 13.93 132 77204 20208 29476983
Epstein-Barr virus associated lymphoma 41.06 13.93 23 77313 557 29496634
Cytogenetic abnormality 41.06 13.93 26 77310 793 29496398
Epstein-Barr virus associated lymphoproliferative disorder 41.00 13.93 35 77301 1703 29495488
B-cell lymphoma refractory 40.65 13.93 15 77321 129 29497062
Wheezing 40.61 13.93 18 77318 33222 29463969
Drug hypersensitivity 40.53 13.93 73 77263 68333 29428858
Wrong technique in product usage process 40.03 13.93 16 77320 31412 29465779
Escherichia infection 39.94 13.93 67 77269 6697 29490494
Haemolysis 39.87 13.93 68 77268 6888 29490303
Infection 39.52 13.93 339 76997 76412 29420779
Congenital cardiovascular anomaly 39.34 13.93 16 77320 183 29497008
Hypoglycaemia 39.30 13.93 41 77295 48305 29448886
Arthropathy 39.27 13.93 5 77331 21549 29475642
Sleep disorder 39.18 13.93 8 77328 24378 29472813
Hepatocellular injury 38.71 13.93 133 77203 21110 29476081
Pulmonary vascular disorder 38.47 13.93 22 77314 555 29496636
Mobility decreased 38.35 13.93 10 77326 25770 29471421
Lentigo 38.01 13.93 19 77317 362 29496829
Adenoviral hepatitis 37.51 13.93 16 77320 208 29496983
Intestinal perforation 37.38 13.93 72 77264 8014 29489177
Ejection fraction decreased 37.33 13.93 109 77227 15869 29481322
Transformation to acute myeloid leukaemia 37.20 13.93 23 77313 672 29496519
Retinal haemorrhage 37.01 13.93 52 77284 4452 29492739
Hepatosplenomegaly 36.80 13.93 47 77289 3670 29493521
Juvenile melanoma benign 36.51 13.93 12 77324 70 29497121
Heart rate decreased 36.42 13.93 10 77326 24902 29472289
Blood stem cell transplant failure 36.35 13.93 19 77317 399 29496792
Adverse drug reaction 36.34 13.93 9 77327 24011 29473180
Aspiration bone marrow abnormal 36.27 13.93 13 77323 102 29497089
Pneumonia aspiration 36.12 13.93 26 77310 36711 29460480
Bacterial infection 35.87 13.93 94 77242 12854 29484337
Cardiac disorder 35.82 13.93 27 77309 37236 29459955
Gene mutation 35.40 13.93 26 77310 1015 29496176
Atrial fibrillation 35.37 13.93 149 77187 105497 29391694
Abdominal discomfort 35.27 13.93 44 77292 47859 29449332
Skin exfoliation 35.22 13.93 8 77328 22637 29474554
Gastrointestinal toxicity 34.89 13.93 35 77301 2096 29495095
Cardio-respiratory arrest 34.69 13.93 49 77287 50552 29446639
Enterocolitis infectious 34.65 13.93 28 77308 1261 29495930
Pneumonitis 34.38 13.93 155 77181 27889 29469302
Inappropriate antidiuretic hormone secretion 34.08 13.93 83 77253 10849 29486342
Haematochezia 34.03 13.93 28 77308 36955 29460236
Unevaluable event 33.68 13.93 18 77318 29833 29467358
Central nervous system lymphoma 33.58 13.93 22 77314 712 29496479
Pneumonia viral 33.55 13.93 38 77298 2617 29494574
Varicella zoster virus infection 33.49 13.93 29 77307 1439 29495752
Injury 33.32 13.93 5 77331 19041 29478150
Treatment noncompliance 33.11 13.93 11 77325 24216 29472975
Blood pressure fluctuation 33.08 13.93 6 77330 19888 29477303
Hepatomegaly 32.59 13.93 74 77262 9243 29487948
Oesophageal stenosis 32.37 13.93 29 77307 1506 29495685
Hepatosplenic candidiasis 32.35 13.93 14 77322 189 29497002
Central nervous system neoplasm 32.27 13.93 11 77325 73 29497118
Ganglioneuroblastoma 32.14 13.93 9 77327 27 29497164
Bone marrow disorder 32.09 13.93 29 77307 1523 29495668
Serotonin syndrome 32.05 13.93 4 77332 17508 29479683
Anal inflammation 32.05 13.93 16 77320 304 29496887
Gastrointestinal haemorrhage 31.97 13.93 104 77232 79429 29417762
Central nervous system leukaemia 31.82 13.93 15 77321 250 29496941
Respiratory failure 31.79 13.93 391 76945 96740 29400451
Pulmonary arteriopathy 31.65 13.93 11 77325 78 29497113
Autoimmune lymphoproliferative syndrome 31.63 13.93 13 77323 153 29497038
Clostridium test positive 31.45 13.93 33 77303 2084 29495107
Neurofibrosarcoma 31.42 13.93 9 77327 30 29497161
Xanthogranuloma 31.38 13.93 10 77326 52 29497139
Cystitis haemorrhagic 31.34 13.93 50 77286 4792 29492399
Leukaemia recurrent 31.33 13.93 28 77308 1449 29495742
Neuroleptic malignant syndrome 31.30 13.93 3 77333 16145 29481046
Device related thrombosis 31.16 13.93 23 77313 905 29496286
Human rhinovirus test positive 31.11 13.93 13 77323 160 29497031
Acute monocytic leukaemia 30.96 13.93 16 77320 328 29496863
Hyperkalaemia 30.85 13.93 72 77264 61320 29435871
Hypersensitivity 30.84 13.93 57 77279 52846 29444345
Pleural effusion 30.65 13.93 305 77031 71603 29425588
Contusion 30.58 13.93 22 77314 31073 29466118
Nephrolithiasis 30.50 13.93 14 77322 25320 29471871
Blood pressure systolic increased 30.46 13.93 4 77332 16841 29480350
Left ventricular dysfunction 30.36 13.93 70 77266 8832 29488359
Cerebral thrombosis 30.20 13.93 22 77314 848 29496343
Weight decreased 30.18 13.93 251 77085 150654 29346537
Hepatic infection fungal 30.14 13.93 13 77323 174 29497017
Therapy non-responder 30.12 13.93 160 77176 30751 29466440
Primitive neuroectodermal tumour 30.05 13.93 10 77326 61 29497130
Gastrooesophageal reflux disease 30.04 13.93 23 77313 31473 29465718
Road traffic accident 29.88 13.93 3 77333 15558 29481633
Ill-defined disorder 29.55 13.93 82 77254 11596 29485595
Abdominal pain upper 29.49 13.93 73 77263 60920 29436271
Delayed puberty 29.42 13.93 13 77323 185 29497006
Cytomegalovirus infection reactivation 29.38 13.93 40 77296 3324 29493867
Adverse event 29.22 13.93 3 77333 15288 29481903
Gallbladder oedema 29.11 13.93 13 77323 190 29497001
Abnormal behaviour 29.08 13.93 12 77324 23115 29474076
Encephalitis enteroviral 28.91 13.93 12 77324 145 29497046
Superior sagittal sinus thrombosis 28.68 13.93 14 77322 253 29496938
Pneumonia fungal 28.64 13.93 53 77283 5724 29491467
Recurrent cancer 28.59 13.93 24 77312 1141 29496050
Molluscum contagiosum 28.58 13.93 14 77322 255 29496936
Respiratory distress 28.48 13.93 162 77174 31944 29465247
Peripheral motor neuropathy 28.47 13.93 28 77308 1637 29495554
International normalised ratio increased 28.44 13.93 45 77291 44327 29452864
Fluid retention 28.40 13.93 13 77323 23547 29473644
Bradycardia 28.37 13.93 83 77253 65546 29431645
Erythema 28.26 13.93 102 77234 75504 29421687
Haemoglobin abnormal 28.24 13.93 38 77298 3123 29494068
Product quality issue 28.21 13.93 4 77332 15891 29481300
Hot flush 28.21 13.93 3 77333 14867 29482324
Bone marrow infiltration 28.09 13.93 11 77325 113 29497078
Lower respiratory tract infection fungal 28.08 13.93 18 77318 561 29496630
Epstein-Barr viraemia 27.91 13.93 22 77314 956 29496235
Flushing 27.87 13.93 21 77315 28971 29468220
Rhinovirus infection 27.73 13.93 38 77298 3178 29494013
Hereditary motor and sensory neuropathy 27.69 13.93 7 77329 12 29497179
Hepatic candidiasis 27.60 13.93 9 77327 51 29497140
Pseudomonas test positive 27.38 13.93 21 77315 876 29496315
Drug reaction with eosinophilia and systemic symptoms 27.27 13.93 20 77316 27972 29469219
Depressed mood 27.26 13.93 5 77331 16443 29480748
Cardiac arrest 27.25 13.93 123 77213 85468 29411723
Subdural hygroma 27.18 13.93 14 77322 285 29496906
Respiratory arrest 27.11 13.93 17 77319 25816 29471375
Blood HIV RNA increased 27.01 13.93 22 77314 1002 29496189
Herpes simplex encephalitis 26.91 13.93 14 77322 291 29496900
Transaminases increased 26.84 13.93 124 77212 22538 29474653
Staphylococcal bacteraemia 26.76 13.93 58 77278 7021 29490170
Erectile dysfunction 26.76 13.93 7 77329 18002 29479189
Acute promyelocytic leukaemia 26.74 13.93 16 77320 440 29496751
Aplastic anaemia 26.66 13.93 60 77276 7450 29489741
Cellulitis gangrenous 26.53 13.93 12 77324 181 29497010
Amnesia 26.51 13.93 13 77323 22630 29474561
Liver function test abnormal 26.48 13.93 22 77314 28896 29468295
Klebsiella sepsis 26.37 13.93 27 77309 1657 29495534
COVID-19 pneumonia 26.24 13.93 69 77267 9453 29487738
Medulloblastoma recurrent 26.24 13.93 9 77327 61 29497130
Myelitis transverse 26.02 13.93 21 77315 944 29496247
Enterococcal infection 26.01 13.93 63 77273 8205 29488986
Azoospermia 25.82 13.93 15 77321 390 29496801
Central nervous system fungal infection 25.44 13.93 14 77322 327 29496864
Cerebral aspergillosis 25.44 13.93 24 77312 1332 29495859
Nervous system disorder 25.44 13.93 82 77254 12592 29484599
Nausea 25.35 13.93 570 76766 288685 29208506
Coma 25.29 13.93 40 77296 39410 29457781
Urticaria 25.21 13.93 67 77269 54593 29442598
Disorientation 25.16 13.93 24 77312 29491 29467700
Intestinal atresia 24.96 13.93 9 77327 72 29497119
Lung opacity 24.91 13.93 24 77312 1368 29495823
Drug clearance decreased 24.36 13.93 24 77312 1406 29495785
Ototoxicity 24.34 13.93 25 77311 1540 29495651
Body height below normal 24.13 13.93 12 77324 226 29496965
Metastases to spleen 24.03 13.93 14 77322 366 29496825
Positron emission tomogram abnormal 23.86 13.93 10 77326 124 29497067
Blood creatinine increased 23.80 13.93 128 77208 84974 29412217
Pseudomonal bacteraemia 23.80 13.93 20 77316 952 29496239
Ameloblastoma 23.65 13.93 9 77327 85 29497106
Refractory cancer 23.65 13.93 10 77326 127 29497064
Disorder of orbit 23.56 13.93 9 77327 86 29497105
Transient ischaemic attack 23.49 13.93 16 77320 23254 29473937
Refractory anaemia with an excess of blasts 23.46 13.93 14 77322 383 29496808
Lung infiltration 23.46 13.93 76 77260 11703 29485488
Loss of CAR T-cell persistence 23.45 13.93 7 77329 28 29497163
Platelet transfusion 23.40 13.93 21 77315 1093 29496098
Swelling 23.36 13.93 35 77301 35248 29461943
Chromosome analysis abnormal 23.31 13.93 10 77326 132 29497059
Chloroma 23.30 13.93 15 77321 471 29496720
Toxicity to various agents 23.29 13.93 317 77019 173344 29323847
Rhabdomyosarcoma recurrent 23.29 13.93 9 77327 89 29497102
Suspected product quality issue 23.24 13.93 10 77326 133 29497058
Glioblastoma multiforme 23.23 13.93 17 77319 660 29496531
Peripheral sensorimotor neuropathy 23.23 13.93 23 77313 1356 29495835
Parainfluenzae virus infection 23.16 13.93 29 77307 2220 29494971
Lymphoma 22.91 13.93 67 77269 9761 29487430
Skin discolouration 22.88 13.93 6 77330 15403 29481788
Administration site extravasation 22.85 13.93 15 77321 487 29496704
Vision blurred 22.79 13.93 44 77292 40132 29457059
Oesophageal candidiasis 22.76 13.93 38 77298 3783 29493408
Cerebral toxoplasmosis 22.71 13.93 23 77313 1393 29495798
Disseminated intravascular coagulation 22.69 13.93 108 77228 19872 29477319
Intestinal pseudo-obstruction 22.66 13.93 22 77314 1266 29495925
Heart rate increased 22.65 13.93 42 77294 38896 29458295
Hepatitis viral 22.40 13.93 15 77321 504 29496687
Myocardial ischaemia 22.39 13.93 7 77329 16021 29481170
Genotoxicity 22.36 13.93 7 77329 34 29497157
Dysgeusia 22.35 13.93 16 77320 22658 29474533
Sleep apnoea syndrome 22.34 13.93 9 77327 17590 29479601
Pneumocystis jirovecii infection 22.28 13.93 23 77313 1425 29495766
Orthostatic hypotension 22.26 13.93 16 77320 22613 29474578
Burning sensation 22.20 13.93 7 77329 15931 29481260
Pulmonary sarcoidosis 22.19 13.93 15 77321 512 29496679
Mass 22.17 13.93 54 77282 7057 29490134
Acute lung injury 22.02 13.93 22 77314 1311 29495880
Influenza 21.95 13.93 48 77288 41833 29455358
Psychotic disorder 21.91 13.93 13 77323 20341 29476850
Electrocardiogram QT prolonged 21.90 13.93 38 77298 36099 29461092
Angioedema 21.77 13.93 31 77305 31884 29465307
Rash pruritic 21.75 13.93 16 77320 22347 29474844
Clostridium difficile colitis 21.74 13.93 80 77256 13132 29484059
Arthritis 21.73 13.93 20 77316 24999 29472192
Labelled drug-drug interaction medication error 21.72 13.93 3 77333 12156 29485035
Metastases to retroperitoneum 21.71 13.93 11 77325 216 29496975
Peripheral sensory neuropathy 21.70 13.93 48 77288 5891 29491300
Morphoea 21.58 13.93 10 77326 160 29497031
Lymphocytosis 21.56 13.93 26 77310 1914 29495277
Meningitis cryptococcal 21.50 13.93 27 77309 2073 29495118
Vocal cord paralysis 21.36 13.93 18 77318 860 29496331
Eczema 21.27 13.93 5 77331 13821 29483370
Localised infection 21.25 13.93 5 77331 13811 29483380
Periorbital infection 21.17 13.93 9 77327 116 29497075
Renal salt-wasting syndrome 21.14 13.93 10 77326 168 29497023
Personality change due to a general medical condition 21.13 13.93 7 77329 42 29497149
Metastases to bone marrow 20.97 13.93 14 77322 468 29496723
Haemorrhage 20.97 13.93 55 77281 45017 29452174
Palpitations 20.95 13.93 33 77303 32571 29464620
Musculoskeletal pain 20.89 13.93 27 77309 28926 29468265
Stomatococcal infection 20.83 13.93 9 77327 121 29497070
Phlebitis infective 20.83 13.93 9 77327 121 29497070
Retinopathy proliferative 20.80 13.93 8 77328 78 29497113
Influenza like illness 20.74 13.93 20 77316 24450 29472741
Sphingomonas paucimobilis infection 20.73 13.93 7 77329 45 29497146
Agitation 20.67 13.93 67 77269 51237 29445954
Chronic lymphocytic leukaemia refractory 20.53 13.93 8 77328 81 29497110
Viral load increased 20.43 13.93 26 77310 2023 29495168
Visual impairment 20.13 13.93 29 77307 29679 29467512
Restlessness 20.08 13.93 17 77319 22128 29475063
Deafness neurosensory 20.06 13.93 29 77307 2549 29494642
Stevens-Johnson syndrome 20.04 13.93 9 77327 16488 29480703
Small intestinal perforation 20.01 13.93 23 77313 1609 29495582
Taeniasis 19.86 13.93 7 77329 52 29497139
Metapneumovirus infection 19.80 13.93 15 77321 614 29496577
Cerebral salt-wasting syndrome 19.74 13.93 7 77329 53 29497138
Microgenia 19.62 13.93 5 77331 9 29497182
Disseminated cytomegaloviral infection 19.62 13.93 10 77326 199 29496992
Vertigo 19.56 13.93 17 77319 21844 29475347
Splenic marginal zone lymphoma 19.54 13.93 6 77330 27 29497164
Gastrosplenic fistula 19.54 13.93 6 77330 27 29497164
Diverticulitis 19.50 13.93 11 77325 17693 29479498
Delusion 19.49 13.93 3 77333 11213 29485978
Stem cell transplant 19.47 13.93 25 77311 1962 29495229
BK virus infection 19.46 13.93 40 77296 4667 29492524
Rectal haemorrhage 19.45 13.93 38 77298 34511 29462680
Injection site reaction 19.43 13.93 3 77333 11185 29486006
Focal nodular hyperplasia 19.31 13.93 9 77327 146 29497045
Blood glucose decreased 19.30 13.93 4 77332 12065 29485126
Vagus nerve paralysis 19.28 13.93 5 77331 10 29497181
Epidermal necrosis 19.22 13.93 13 77323 444 29496747
Blood bilirubin increased 19.19 13.93 153 77183 33740 29463451
Marginal zone lymphoma recurrent 19.19 13.93 6 77330 29 29497162
Head injury 19.18 13.93 9 77327 16072 29481119
Diabetic ketoacidosis 19.17 13.93 9 77327 16064 29481127
Metastases to muscle 19.09 13.93 10 77326 211 29496980
Basal cell naevus syndrome 19.02 13.93 6 77330 30 29497161
Bacillus test positive 19.02 13.93 6 77330 30 29497161
Withdrawal syndrome 18.97 13.93 3 77333 10989 29486202
Hepatic amoebiasis 18.89 13.93 7 77329 61 29497130
Candida endophthalmitis 18.82 13.93 8 77328 103 29497088
Respiratory depression 18.72 13.93 6 77330 13517 29483674
Vascular access complication 18.67 13.93 10 77326 221 29496970
Disseminated cryptococcosis 18.65 13.93 19 77317 1159 29496032
Pathogen resistance 18.60 13.93 55 77281 8061 29489130
Pancreatitis 18.57 13.93 154 77182 34360 29462831
Hallucination, visual 18.54 13.93 8 77328 15007 29482184
Pseudomonal sepsis 18.52 13.93 30 77306 2912 29494279
Astrocytoma 18.52 13.93 9 77327 161 29497030
Hypersomnia 18.41 13.93 3 77333 10751 29486440
Haematopoietic stem cell mobilisation 18.37 13.93 9 77327 164 29497027
Feeding intolerance 18.35 13.93 8 77328 110 29497081
Faeces discoloured 18.35 13.93 6 77330 13345 29483846
Infusion site discolouration 18.29 13.93 8 77328 111 29497080
Blood cholesterol increased 18.19 13.93 9 77327 15586 29481605
Gastric stenosis 18.11 13.93 6 77330 36 29497155
Acute myelomonocytic leukaemia 18.10 13.93 8 77328 114 29497077
Therapy responder 18.03 13.93 9 77327 171 29497020
Renal tubular disorder 18.01 13.93 37 77299 4315 29492876
Chronic myeloid leukaemia 17.86 13.93 24 77312 1970 29495221
Adenocarcinoma gastric 17.85 13.93 18 77318 1085 29496106
Splenic candidiasis 17.78 13.93 7 77329 73 29497118
Meningitis tuberculous 17.71 13.93 14 77322 611 29496580
Delirium 17.63 13.93 49 77287 39348 29457843
Disturbance in attention 17.60 13.93 18 77318 21406 29475785
Candida sepsis 17.57 13.93 18 77318 1105 29496086
Blood urea increased 17.55 13.93 29 77307 28083 29469108
Bone marrow necrosis 17.55 13.93 8 77328 123 29497068
Therapy cessation 17.40 13.93 8 77328 14454 29482737
Hepatitis 17.22 13.93 103 77233 20680 29476511
Premature ageing 17.21 13.93 7 77329 80 29497111
Enterovirus test positive 17.21 13.93 6 77330 43 29497148
Secondary immunodeficiency 17.12 13.93 11 77325 344 29496847
Dyspepsia 17.08 13.93 33 77303 30092 29467099
Skin laceration 17.02 13.93 4 77332 11058 29486133
Osteosarcoma 17.01 13.93 9 77327 194 29496997
Abdominal neoplasm 17.01 13.93 9 77327 194 29496997
Urinary bladder rupture 16.98 13.93 7 77329 83 29497108
Bladder cancer 16.95 13.93 3 77333 10124 29487067
Coronary artery occlusion 16.88 13.93 3 77333 10091 29487100
Traumatic lung injury 16.83 13.93 18 77318 1162 29496029
Diabetes mellitus 16.76 13.93 51 77285 39780 29457411
Helicobacter sepsis 16.75 13.93 5 77331 20 29497171
Escherichia test positive 16.73 13.93 17 77319 1034 29496157
5q minus syndrome 16.67 13.93 8 77328 139 29497052
Respiratory tract infection fungal 16.65 13.93 14 77322 667 29496524
Synovitis 16.63 13.93 4 77332 10886 29486305
Gastrointestinal necrosis 16.61 13.93 29 77307 2993 29494198
Total lung capacity decreased 16.53 13.93 13 77323 563 29496628
Leukaemia 16.49 13.93 33 77303 3777 29493414
Plasma cell myeloma refractory 16.48 13.93 7 77329 90 29497101
Optic glioma 16.37 13.93 5 77331 22 29497169
Psoriatic arthropathy 16.36 13.93 9 77327 14682 29482509
Pneumothorax spontaneous 16.34 13.93 11 77325 373 29496818
Accidental exposure to product 16.32 13.93 4 77332 10749 29486442
Alanine aminotransferase increased 16.14 13.93 268 77068 70676 29426515
Acute hepatic failure 16.12 13.93 68 77268 11884 29485307
Bladder spasm 16.12 13.93 15 77321 818 29496373
Melaena 16.11 13.93 36 77300 31140 29466051
Subclavian vein thrombosis 16.09 13.93 15 77321 820 29496371
Streptococcal infection 16.09 13.93 36 77300 4452 29492739
Urinary tract obstruction 16.03 13.93 30 77306 3267 29493924
Swollen tongue 16.02 13.93 6 77330 12260 29484931
Postural tremor 16.00 13.93 10 77326 298 29496893
Cardiomegaly 15.99 13.93 8 77328 13768 29483423
Hepatitis B DNA increased 15.95 13.93 12 77324 486 29496705
Plasmablastic lymphoma 15.92 13.93 9 77327 222 29496969
Renal impairment 15.91 13.93 136 77200 81197 29415994
Lymphocytic leukaemia 15.79 13.93 8 77328 157 29497034
Enterovesical fistula 15.78 13.93 13 77323 602 29496589
Proteinuria 15.77 13.93 11 77325 15793 29481398
Pneumoperitoneum 15.75 13.93 20 77316 1553 29495638
Diabetes mellitus inadequate control 15.74 13.93 6 77330 12128 29485063
Hallucination, auditory 15.72 13.93 3 77333 9590 29487601
Irritability 15.63 13.93 21 77315 22131 29475060
Gait inability 15.59 13.93 15 77321 18360 29478831
Ganglioneuroma 15.42 13.93 4 77332 8 29497183
Retroperitoneal lymphadenopathy 15.37 13.93 14 77322 743 29496448
Sinus tachycardia 15.36 13.93 79 77257 14990 29482201
Vocal cord paresis 15.33 13.93 7 77329 108 29497083
Mastitis 15.30 13.93 8 77328 168 29497023
Human metapneumovirus test positive 15.29 13.93 6 77330 62 29497129
B-cell lymphoma 15.26 13.93 32 77304 3786 29493405
Congenital hepatobiliary anomaly 15.24 13.93 5 77331 29 29497162
Haemofiltration 15.21 13.93 6 77330 63 29497128
Limb injury 15.17 13.93 3 77333 9352 29487839
Dyspnoea exertional 15.15 13.93 47 77289 36443 29460748
Hyperpyrexia 15.15 13.93 24 77312 2286 29494905
Blastic plasmacytoid dendritic cell neoplasia 15.12 13.93 6 77330 64 29497127
Peripheral T-cell lymphoma unspecified 15.10 13.93 11 77325 424 29496767
Superior vena cava syndrome 15.07 13.93 12 77324 529 29496662
Chronic kidney disease 15.05 13.93 47 77289 36369 29460822
Cardiac dysfunction 15.05 13.93 21 77315 1786 29495405
Aeromonas infection 15.02 13.93 9 77327 248 29496943
Hypouricaemia 14.96 13.93 9 77327 250 29496941
Blindness cortical 14.96 13.93 10 77326 335 29496856
Multiple lentigines syndrome 14.96 13.93 5 77331 31 29497160
Neuroborreliosis 14.96 13.93 5 77331 31 29497160
Frequent bowel movements 14.90 13.93 3 77333 9236 29487955
Sopor 14.88 13.93 5 77331 10929 29486262
Geotrichum infection 14.87 13.93 11 77325 434 29496757
Gastrointestinal injury 14.72 13.93 10 77326 344 29496847
Post-acute COVID-19 syndrome 14.69 13.93 5 77331 33 29497158
Hypothyroidism 14.68 13.93 12 77324 15894 29481297
Product use issue 14.67 13.93 202 77134 51242 29445949
Sinus bradycardia 14.62 13.93 6 77330 11597 29485594
Salivary gland cancer 14.61 13.93 9 77327 261 29496930
Decreased appetite 14.58 13.93 280 77056 145062 29352129
Paternal exposure timing unspecified 14.56 13.93 5 77331 34 29497157
Lewis-Sumner syndrome 14.56 13.93 5 77331 34 29497157
Hypophagia 14.54 13.93 99 77237 20773 29476418
Liver tenderness 14.51 13.93 7 77329 123 29497068
Neck pain 14.46 13.93 21 77315 21426 29475765
T-cell prolymphocytic leukaemia 14.44 13.93 5 77331 35 29497156
Abdominal mass 14.41 13.93 17 77319 1223 29495968
Mucosal toxicity 14.38 13.93 8 77328 191 29497000
Pneumatosis intestinalis 14.38 13.93 28 77308 3141 29494050
Skin toxicity 14.37 13.93 31 77305 3740 29493451
Obesity 14.34 13.93 4 77332 9859 29487332
Pneumaturia 14.32 13.93 5 77331 36 29497155
Congenital herpes simplex infection 14.32 13.93 5 77331 36 29497155
Splenic lesion 14.31 13.93 7 77329 127 29497064
Body temperature decreased 14.30 13.93 5 77331 10659 29486532
Metapneumovirus bronchiolitis 14.28 13.93 4 77332 12 29497179
Peripheral T-cell lymphoma unspecified refractory 14.28 13.93 4 77332 12 29497179
Spindle cell sarcoma 14.26 13.93 7 77329 128 29497063
Meningitis bacterial 14.25 13.93 16 77320 1091 29496100
Humoral immune defect 14.20 13.93 6 77330 76 29497115
Iris atrophy 14.20 13.93 6 77330 76 29497115
Protein S decreased 14.20 13.93 5 77331 37 29497154
Neoplasm malignant 14.15 13.93 14 77322 16911 29480280
Chronic lymphocytic leukaemia recurrent 14.13 13.93 10 77326 368 29496823
Laboratory test abnormal 14.13 13.93 16 77320 18169 29479022
Medication error 14.08 13.93 21 77315 21190 29476001
Facial paresis 14.07 13.93 25 77311 2616 29494575
Urinary retention 14.03 13.93 40 77296 31858 29465333
Optic ischaemic neuropathy 14.02 13.93 21 77315 1905 29495286
Neurological decompensation 14.02 13.93 24 77312 2438 29494753
Acinetobacter sepsis 13.97 13.93 5 77331 39 29497152

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 7031.66 13.21 4374 117670 183283 64193405
Neutropenia 2309.87 13.21 2541 119503 237083 64139605
Product use in unapproved indication 1364.82 13.21 1674 120370 174944 64201744
Haematotoxicity 1204.55 13.21 555 121489 12341 64364347
Second primary malignancy 992.43 13.21 479 121565 11858 64364830
Bone marrow failure 982.13 13.21 776 121268 47176 64329512
Febrile bone marrow aplasia 941.81 13.21 449 121595 10806 64365882
Pancytopenia 918.46 13.21 1239 120805 142070 64234618
Mucosal inflammation 887.19 13.21 820 121224 61764 64314924
Myelodysplastic syndrome 829.35 13.21 563 121481 27016 64349672
Diffuse large B-cell lymphoma recurrent 808.37 13.21 281 121763 2865 64373823
Acute myeloid leukaemia 800.62 13.21 550 121494 26913 64349775
Myelosuppression 732.09 13.21 493 121551 23337 64353351
Posterior reversible encephalopathy syndrome 698.41 13.21 472 121572 22474 64354214
Tumour lysis syndrome 691.89 13.21 441 121603 18999 64357689
Hepatitis B reactivation 691.20 13.21 282 121762 4607 64372081
Hepatitis B 654.12 13.21 311 121733 7434 64369254
Sepsis 612.14 13.21 1347 120697 228994 64147694
Thrombocytopenia 602.92 13.21 1316 120728 222485 64154203
Off label use 588.81 13.21 2558 119486 630248 63746440
Venoocclusive liver disease 525.86 13.21 292 121752 9723 64366965
Septic shock 521.79 13.21 807 121237 104630 64272058
Pyrexia 490.69 13.21 2221 119823 556423 63820265
Neuropathy peripheral 468.65 13.21 816 121228 116709 64259979
Fall 438.98 13.21 123 121921 416703 63959985
Neoplasm progression 410.77 13.21 445 121599 40519 64336169
Neutropenic sepsis 405.49 13.21 343 121701 22929 64353759
Disease progression 403.80 13.21 853 121191 140827 64235861
Pain 396.43 13.21 283 121761 553228 63823460
Hypofibrinogenaemia 392.89 13.21 142 121902 1636 64375052
Leukopenia 353.86 13.21 664 121380 100578 64276110
Acute lymphocytic leukaemia recurrent 344.03 13.21 163 121881 3863 64372825
Joint swelling 343.65 13.21 15 122029 215367 64161321
Cytopenia 337.33 13.21 260 121784 15211 64361477
Arthralgia 332.62 13.21 214 121830 442046 63934642
Cytomegalovirus chorioretinitis 324.79 13.21 167 121877 4745 64371943
Pneumocystis jirovecii pneumonia 319.56 13.21 324 121720 27310 64349378
Multiple organ dysfunction syndrome 315.20 13.21 633 121411 100780 64275908
Interstitial lung disease 312.12 13.21 617 121427 97115 64279573
Neutrophil count decreased 310.13 13.21 538 121506 76658 64300030
Product dose omission issue 302.82 13.21 16 122028 194731 64181957
Rheumatoid arthritis 289.85 13.21 4 122040 164290 64212398
Progressive multifocal leukoencephalopathy 289.79 13.21 255 121789 17977 64358711
Pruritus 288.79 13.21 115 121929 312285 64064403
Fatigue 288.67 13.21 618 121426 748112 63628576
Dizziness 287.14 13.21 236 121808 429927 63946761
Cardiotoxicity 281.11 13.21 198 121846 10076 64366612
Neurotoxicity 275.21 13.21 298 121746 27106 64349582
Ototoxicity 272.45 13.21 123 121921 2600 64374088
Diffuse large B-cell lymphoma refractory 271.90 13.21 96 121948 1028 64375660
Peripheral swelling 266.91 13.21 39 122005 209114 64167574
Malignant neoplasm progression 264.70 13.21 629 121415 112242 64264446
Aspergillus infection 260.15 13.21 229 121815 16150 64360538
Therapy partial responder 256.30 13.21 187 121857 10061 64366627
B-cell lymphoma recurrent 247.70 13.21 83 121961 749 64375939
Haemophagocytic lymphohistiocytosis 243.96 13.21 228 121816 17381 64359307
Hypertriglyceridaemia 243.60 13.21 188 121856 11017 64365671
Bacteraemia 243.30 13.21 277 121767 26634 64350054
Secondary immunodeficiency 241.10 13.21 113 121931 2611 64374077
Dyspnoea 238.14 13.21 642 121402 718032 63658656
Drug resistance 237.33 13.21 312 121732 34790 64341898
Aplasia 235.63 13.21 153 121891 6800 64369888
Nasopharyngitis 227.33 13.21 47 121997 196026 64180662
Rash 225.72 13.21 324 121720 458225 63918463
Disease recurrence 223.84 13.21 287 121757 31223 64345465
Weight increased 220.46 13.21 65 121979 213283 64163405
Acquired gene mutation 218.88 13.21 96 121948 1890 64374798
Hyperbilirubinaemia 215.38 13.21 232 121812 20973 64355715
Insomnia 208.60 13.21 58 121986 197778 64178910
Malaise 208.05 13.21 267 121777 395980 63980708
Arthropathy 197.68 13.21 7 122037 120960 64255728
Epstein-Barr virus infection 197.12 13.21 174 121870 12314 64364374
Drug abuse 196.33 13.21 14 122030 132360 64244328
Headache 195.37 13.21 447 121597 529020 63847668
Bronchopulmonary aspergillosis 194.18 13.21 209 121835 18876 64357812
Neoplasm recurrence 193.48 13.21 108 121936 3631 64373057
Abdominal discomfort 193.06 13.21 53 121991 182269 64194419
Anxiety 189.76 13.21 73 121971 202576 64174112
Platelet count decreased 188.71 13.21 721 121323 166990 64209698
Polyneuropathy 187.03 13.21 209 121835 19685 64357003
Neutropenic colitis 183.30 13.21 112 121932 4469 64372219
Drug hypersensitivity 179.93 13.21 114 121930 237701 64138987
Lymphopenia 179.58 13.21 232 121812 25425 64351263
Leukoencephalopathy 178.47 13.21 129 121915 6838 64369850
Myelopathy 176.75 13.21 104 121940 3870 64372818
Hypogammaglobulinaemia 175.69 13.21 150 121894 10149 64366539
Post transplant lymphoproliferative disorder 173.09 13.21 144 121900 9400 64367288
Venoocclusive disease 171.26 13.21 102 121942 3883 64372805
Swelling 170.70 13.21 46 121998 160172 64216516
Candida infection 168.68 13.21 250 121794 31169 64345519
Synovitis 168.25 13.21 4 122040 99086 64277602
Feeling abnormal 167.88 13.21 26 122018 133576 64243112
Cardiomyopathy 167.73 13.21 223 121821 25133 64351555
Acute lymphocytic leukaemia 167.60 13.21 104 121940 4267 64372421
Injection site pain 167.49 13.21 11 122033 111397 64265291
Musculoskeletal stiffness 166.68 13.21 19 122025 123187 64253501
Bacterial infection 165.92 13.21 220 121824 24730 64351958
Diffuse large B-cell lymphoma 162.81 13.21 144 121900 10217 64366471
Ileus paralytic 161.05 13.21 131 121913 8284 64368404
Pain in extremity 160.24 13.21 203 121841 302882 64073806
Blood pressure increased 156.87 13.21 65 121979 172487 64204201
White blood cell count decreased 153.10 13.21 648 121396 157189 64219499
Overdose 151.83 13.21 56 121988 159510 64217178
Muscle spasms 151.14 13.21 40 122004 140983 64235705
Mantle cell lymphoma recurrent 150.32 13.21 50 121994 440 64376248
Lymphadenopathy 149.22 13.21 295 121749 46391 64330297
Myocardial infarction 145.12 13.21 66 121978 165755 64210933
Cytomegalovirus infection 145.07 13.21 256 121788 36943 64339745
Mucormycosis 142.01 13.21 115 121929 7226 64369462
Hepatic failure 139.93 13.21 318 121726 55076 64321612
Herpes simplex 139.40 13.21 133 121911 10403 64366285
Staphylococcal bacteraemia 131.88 13.21 128 121916 10227 64366461
Contusion 130.63 13.21 28 122016 113937 64262751
Blood culture positive 128.94 13.21 112 121932 7756 64368932
Pneumatosis intestinalis 127.55 13.21 94 121950 5135 64371553
Cytokine release syndrome 126.86 13.21 176 121868 20653 64356035
Parainfluenzae virus infection 126.49 13.21 90 121954 4653 64372035
Anaemia 126.06 13.21 1180 120864 377500 63999188
Colitis 125.73 13.21 316 121728 58358 64318330
Inappropriate schedule of product administration 125.40 13.21 14 122030 92272 64284416
Diarrhoea 123.76 13.21 831 121213 721873 63654815
Stomatitis 123.01 13.21 471 121573 109134 64267554
Systemic candida 121.51 13.21 92 121952 5237 64371451
Asthma 120.83 13.21 18 122026 95207 64281481
Hypersensitivity 117.44 13.21 119 121925 196333 64180355
Ejection fraction decreased 115.09 13.21 200 121844 28507 64348181
Death 112.81 13.21 500 121544 482205 63894483
Klebsiella infection 112.13 13.21 132 121912 13149 64363539
Intentional product misuse 112.11 13.21 6 122038 72289 64304399
Rhabdomyolysis 110.44 13.21 20 122024 91706 64284982
Nausea 109.36 13.21 957 121087 784843 63591845
Psoriasis 107.99 13.21 7 122037 71696 64304992
Chest pain 107.90 13.21 175 121869 235805 64140883
Clostridium difficile colitis 106.98 13.21 188 121856 27035 64349653
Depression 106.21 13.21 114 121930 183177 64193511
Back pain 105.75 13.21 195 121849 249976 64126712
Discomfort 105.63 13.21 14 122030 80864 64295824
Wound 105.44 13.21 11 122033 76466 64300222
Pseudomonal sepsis 104.25 13.21 83 121961 5089 64371599
Respiratory failure 103.97 13.21 589 121455 160594 64216094
Escherichia bacteraemia 103.16 13.21 84 121960 5319 64371369
Agranulocytosis 102.76 13.21 225 121819 38004 64338684
Gene mutation 101.94 13.21 58 121986 2024 64374664
Myalgia 101.92 13.21 90 121954 158527 64218161
Injection site erythema 100.73 13.21 9 122035 70791 64305897
Stress 100.67 13.21 3 122041 60531 64316157
Mycobacterium chelonae infection 100.53 13.21 58 121986 2079 64374609
Rhinovirus infection 99.61 13.21 87 121957 6069 64370619
Urticaria 99.05 13.21 80 121964 147237 64229451
Hepatotoxicity 98.25 13.21 227 121817 39735 64336953
Abdominal pain upper 97.96 13.21 112 121932 174918 64201770
Peripheral sensory neuropathy 97.58 13.21 114 121930 11264 64365424
Arthritis 97.26 13.21 20 122024 83794 64292894
Disseminated intravascular coagulation 95.73 13.21 198 121846 32150 64344538
Bronchitis 95.55 13.21 43 122001 108700 64267988
Peripheral motor neuropathy 94.89 13.21 63 121981 2907 64373781
Enterococcal infection 94.86 13.21 124 121920 13742 64362946
Blood fibrinogen decreased 94.74 13.21 49 121995 1409 64375279
Epstein-Barr virus associated lymphoproliferative disorder 94.47 13.21 64 121980 3055 64373633
Cerebral venous sinus thrombosis 94.40 13.21 53 121991 1802 64374886
Drug interaction 93.90 13.21 360 121684 361723 64014965
Malignant transformation 93.83 13.21 45 121999 1096 64375592
Hospitalisation 93.62 13.21 15 122029 75192 64301496
Loss of personal independence in daily activities 93.54 13.21 13 122031 72441 64304247
Glioma 93.26 13.21 36 122008 504 64376184
Superior sagittal sinus thrombosis 91.07 13.21 42 122002 934 64375754
Oedema peripheral 89.69 13.21 163 121881 210154 64166534
Cerebrovascular accident 88.46 13.21 78 121966 137505 64239183
Drug intolerance 88.19 13.21 137 121907 187855 64188833
Fungal infection 88.01 13.21 198 121846 34053 64342635
Osteoarthritis 87.59 13.21 9 122035 63327 64313361
Chest discomfort 87.26 13.21 56 121988 116050 64260638
Somnolence 86.69 13.21 158 121886 203487 64173201
Cystitis haemorrhagic 86.01 13.21 90 121954 7866 64368822
JC virus infection 85.66 13.21 62 121982 3293 64373395
Confusional state 85.50 13.21 234 121810 260910 64115778
Bacterial sepsis 85.39 13.21 87 121957 7370 64369318
West Nile viral infection 84.13 13.21 39 122005 878 64375810
Contraindicated product administered 83.82 13.21 50 121994 107779 64268909
Suicidal ideation 83.44 13.21 13 122031 66529 64310159
Lymphadenitis 83.34 13.21 64 121980 3721 64372967
Leukaemia recurrent 82.82 13.21 55 121989 2539 64374149
Glossodynia 82.60 13.21 12 122032 64684 64312004
Antithrombin III decreased 81.90 13.21 31 122013 410 64376278
Pseudomonas infection 81.56 13.21 132 121912 17751 64358937
Remission not achieved 80.79 13.21 29 122015 327 64376361
Encephalopathy 80.68 13.21 270 121774 58549 64318139
Pleural effusion 80.61 13.21 461 121583 126098 64250590
Oesophageal candidiasis 80.15 13.21 87 121957 7930 64368758
Adenovirus infection 80.10 13.21 83 121961 7172 64369516
Smooth muscle cell neoplasm 79.98 13.21 37 122007 829 64375859
Human herpesvirus 6 infection 79.82 13.21 68 121976 4586 64372102
Cytomegalovirus viraemia 79.04 13.21 100 121944 10728 64365960
Hyperhidrosis 78.89 13.21 72 121972 124848 64251840
Wheezing 78.80 13.21 27 122017 80552 64296136
Mobility decreased 78.51 13.21 32 122012 85808 64290880
Osteonecrosis 77.98 13.21 168 121876 28061 64348627
Palpitations 76.35 13.21 52 121992 104436 64272252
Cerebral venous thrombosis 76.11 13.21 51 121993 2390 64374298
Blood pressure fluctuation 75.42 13.21 6 122038 51865 64324823
Device related infection 75.31 13.21 174 121870 30452 64346236
Injury 74.80 13.21 9 122035 55983 64320705
Blood glucose increased 74.11 13.21 47 121997 98026 64278662
Hepatocellular injury 73.35 13.21 220 121824 45015 64331673
Left ventricular dysfunction 73.08 13.21 122 121922 16832 64359856
Deafness 72.41 13.21 127 121917 18232 64358456
Infection reactivation 72.06 13.21 46 121998 1984 64374704
Pseudomonas test positive 71.78 13.21 42 122002 1546 64375142
Staphylococcal sepsis 71.18 13.21 104 121940 12795 64363893
Sweat gland tumour 70.71 13.21 29 122015 480 64376208
Infection 69.50 13.21 592 121452 184288 64192400
Ascites 69.16 13.21 266 121778 61735 64314953
Intussusception 69.04 13.21 34 122010 879 64375809
Injection site reaction 68.97 13.21 5 122039 46659 64330029
Intestinal perforation 68.43 13.21 112 121932 15201 64361487
Hepatomegaly 68.17 13.21 118 121926 16764 64359924
Human bocavirus infection 67.49 13.21 29 122015 542 64376146
Incorrect dose administered 67.47 13.21 16 122028 60749 64315939
Suicide attempt 67.37 13.21 25 122019 70982 64305706
Coombs positive haemolytic anaemia 67.30 13.21 33 122011 845 64375843
Cytogenetic abnormality 67.28 13.21 35 122009 1019 64375669
Coronary artery disease 66.92 13.21 16 122028 60417 64316271
End stage renal disease 66.02 13.21 90 121954 10385 64366303
Loss of consciousness 65.93 13.21 112 121932 148253 64228435
Multiple-drug resistance 65.77 13.21 71 121973 6431 64370257
Human rhinovirus test positive 65.72 13.21 26 122018 390 64376298
Refractory anaemia with an excess of blasts 65.45 13.21 32 122012 814 64375874
Inappropriate antidiuretic hormone secretion 65.44 13.21 136 121908 22153 64354535
Epstein-Barr virus associated lymphoma 65.40 13.21 33 122011 900 64375788
Lymphoma transformation 65.22 13.21 22 122022 203 64376485
Hallucination 65.17 13.21 28 122016 72760 64303928
Vocal cord paralysis 64.91 13.21 44 122000 2102 64374586
Alopecia 64.90 13.21 135 121909 165555 64211133
Memory impairment 64.82 13.21 41 122003 85641 64291047
Fungaemia 64.29 13.21 55 121989 3730 64372958
Central nervous system lymphoma 64.14 13.21 42 122002 1893 64374795
Blood creatine phosphokinase increased 63.88 13.21 16 122028 58542 64318146
Cardiac failure congestive 63.31 13.21 93 121951 130487 64246201
Sinusitis 63.17 13.21 112 121932 145816 64230872
Viral haemorrhagic cystitis 62.93 13.21 39 122005 1596 64375092
Hot flush 62.83 13.21 7 122037 46228 64330460
Injection site swelling 62.38 13.21 4 122040 41349 64335339
Enterovirus infection 61.84 13.21 37 122007 1420 64375268
Glioblastoma multiforme 61.81 13.21 34 122010 1110 64375578
Escherichia sepsis 61.79 13.21 72 121972 7093 64369595
Pneumonia fungal 61.68 13.21 80 121964 8797 64367891
Clostridium difficile infection 61.61 13.21 179 121865 35984 64340704
Respiratory distress 61.25 13.21 228 121816 52103 64324585
Therapeutic product effect decreased 61.12 13.21 77 121967 115274 64261414
Blister 60.90 13.21 39 122005 80928 64295760
Psoriatic arthropathy 60.24 13.21 6 122038 43275 64333413
Heart rate decreased 60.16 13.21 15 122029 55052 64321636
Enterovirus test positive 59.97 13.21 21 122023 219 64376469
Balance disorder 59.68 13.21 43 122001 83883 64292805
Gait disturbance 59.55 13.21 150 121894 172005 64204683
Neck pain 59.50 13.21 21 122023 61512 64315176
Fusarium infection 59.32 13.21 37 122007 1532 64375156
Injection site pruritus 59.08 13.21 3 122041 37823 64338865
Blood lactate dehydrogenase increased 58.55 13.21 166 121878 32912 64343776
Erythema 57.97 13.21 172 121872 186898 64189790
Dry skin 57.73 13.21 13 122031 51148 64325540
Enterobacter infection 57.33 13.21 51 121993 3645 64373043
Systemic mycosis 57.20 13.21 42 122002 2281 64374407
Aplastic anaemia 57.12 13.21 98 121946 13822 64362866
Gastrosplenic fistula 57.03 13.21 16 122028 73 64376615
Blood pressure systolic increased 56.96 13.21 12 122032 49441 64327247
Pulmonary vascular disorder 56.87 13.21 30 122014 899 64375789
Hepatosplenic candidiasis 56.82 13.21 25 122019 496 64376192
Influenza like illness 56.42 13.21 23 122021 61679 64315009
5q minus syndrome 56.30 13.21 21 122023 266 64376422
Pyomyositis 55.96 13.21 25 122019 515 64376173
Serotonin syndrome 55.85 13.21 5 122039 39277 64337411
Burning sensation 55.29 13.21 13 122031 49651 64327037
Chronic obstructive pulmonary disease 55.13 13.21 33 122011 71015 64305673
Varicella zoster virus infection 55.11 13.21 51 121993 3837 64372851
Respiratory arrest 54.92 13.21 16 122028 52969 64323719
Tremor 54.56 13.21 125 121919 148105 64228583
Urinary tract infection 54.49 13.21 239 121805 231357 64145331
Coagulopathy 54.38 13.21 158 121886 31762 64344926
Pneumocystis jirovecii infection 54.36 13.21 41 122003 2320 64374368
Depressed mood 53.78 13.21 7 122037 41005 64335683
Quadriplegia 53.68 13.21 45 121999 2968 64373720
Sleep disorder 53.40 13.21 23 122021 59686 64317002
Asthenia 53.39 13.21 535 121509 427509 63949179
Acute promyelocytic leukaemia 53.15 13.21 33 122011 1355 64375333
Lymphoma 53.12 13.21 95 121949 13846 64362842
Myeloid leukaemia 53.12 13.21 25 122019 583 64376105
Philadelphia chromosome positive 52.77 13.21 25 122019 592 64376096
Flushing 52.48 13.21 43 122001 78605 64298083
Musculoskeletal pain 52.34 13.21 46 121998 81248 64295440
Pneumonia 52.34 13.21 1407 120637 558169 63818519
Bone marrow disorder 52.00 13.21 43 122001 2782 64373906
Stem cell transplant 51.95 13.21 47 121997 3434 64373254
Hypoglycaemia 51.93 13.21 56 121988 89836 64286852
Lung infiltration 51.71 13.21 119 121925 20770 64355918
Mucosal toxicity 51.70 13.21 23 122021 469 64376219
Acute hepatitis B 51.55 13.21 22 122022 404 64376284
Gastrooesophageal reflux disease 51.21 13.21 49 121995 83094 64293594
Gastritis bacterial 50.62 13.21 20 122024 299 64376389
Hyperpyrexia 50.58 13.21 55 121989 5022 64371666
BK virus infection 50.26 13.21 66 121978 7346 64369342
Bradycardia 50.02 13.21 92 121952 118127 64258561
Drug reaction with eosinophilia and systemic symptoms 49.92 13.21 20 122024 54197 64322491
Escherichia infection 49.85 13.21 97 121947 15071 64361617
Treatment noncompliance 49.16 13.21 11 122033 43471 64333217
Hepatitis E 48.97 13.21 39 122005 2392 64374296
Clostridium test positive 48.93 13.21 49 121995 4066 64372622
COVID-19 pneumonia 48.80 13.21 101 121943 16403 64360285
Leukaemia 48.75 13.21 54 121990 5034 64371654
Fluid retention 48.67 13.21 26 122018 59580 64317108
Blood cholesterol increased 48.56 13.21 17 122027 50049 64326639
Impaired healing 48.47 13.21 27 122017 60446 64316242
International normalised ratio increased 48.36 13.21 47 121997 79120 64297568
Cutaneous calcification 48.34 13.21 15 122029 103 64376585
Cytomegalovirus infection reactivation 48.24 13.21 57 121987 5699 64370989
Therapy responder 47.57 13.21 21 122023 420 64376268
Angioedema 47.56 13.21 29 122015 61792 64314896
Syncope 47.36 13.21 147 121897 157488 64219200
Blood stem cell transplant failure 46.75 13.21 22 122022 513 64376175
Congestive cardiomyopathy 46.69 13.21 76 121968 10268 64366420
Adverse drug reaction 46.63 13.21 14 122030 45450 64331238
Pneumonitis 46.61 13.21 204 121840 50161 64326527
Hepatosplenomegaly 46.59 13.21 54 121990 5289 64371399
Salivary gland cancer 46.29 13.21 20 122024 379 64376309
Heart rate increased 46.16 13.21 72 121972 98603 64278085
Enterococcal bacteraemia 45.84 13.21 38 122006 2467 64374221
Recurrent cancer 45.53 13.21 37 122007 2336 64374352
Acute myelomonocytic leukaemia 45.38 13.21 18 122026 272 64376416
Condition aggravated 45.38 13.21 468 121576 371958 64004730
Dyspepsia 45.32 13.21 51 121993 80261 64296427
Acute lymphocytic leukaemia refractory 45.19 13.21 15 122029 131 64376557
Platelet transfusion 45.17 13.21 33 122011 1778 64374910
Peripheral sensorimotor neuropathy 44.80 13.21 38 122006 2547 64374141
Rash pruritic 44.06 13.21 27 122017 57377 64319311
Thymus hypoplasia 43.77 13.21 21 122023 512 64376176
Road traffic accident 43.48 13.21 4 122040 30741 64345947
Feeling hot 43.44 13.21 16 122028 45647 64331041
Anal inflammation 43.44 13.21 20 122024 443 64376245
Vision blurred 43.11 13.21 65 121979 90251 64286437
Duodenal ulcer perforation 42.88 13.21 7 122037 34618 64342070
Strongyloidiasis 42.77 13.21 40 122004 3050 64373638
Cryptococcosis 42.70 13.21 38 122006 2717 64373971
Perineal necrosis 42.52 13.21 14 122030 119 64376569
Plasma cell myeloma 42.41 13.21 17 122027 46058 64330630
Minimal residual disease 42.24 13.21 19 122025 398 64376290
Head injury 42.13 13.21 6 122038 32836 64343852
Bone pain 42.00 13.21 190 121854 47382 64329306
Perineal infection 41.96 13.21 18 122026 335 64376353
Pancreatitis 41.85 13.21 223 121821 59384 64317304
Cardiac failure 41.64 13.21 408 121636 131965 64244723
Cardiomyopathy acute 41.32 13.21 16 122028 226 64376462
Swollen tongue 41.26 13.21 8 122036 34946 64341742
Lentigo 40.77 13.21 19 122025 433 64376255
Trichodysplasia spinulosa 40.68 13.21 22 122022 694 64375994
Hereditary motor and sensory neuropathy 40.61 13.21 13 122031 100 64376588
Hepatic enzyme increased 40.58 13.21 119 121925 129824 64246864
Subdural hygroma 40.53 13.21 19 122025 439 64376249
Cardiac disorder 40.47 13.21 28 122016 55788 64320900
Central nervous system leukaemia 40.46 13.21 18 122026 367 64376321
Cardio-respiratory arrest 40.37 13.21 78 121966 98315 64278373
Heart rate irregular 40.33 13.21 3 122041 27410 64349278
Limb discomfort 39.91 13.21 3 122041 27172 64349516
Pathogen resistance 39.75 13.21 79 121965 12464 64364224
Gastric stenosis 39.74 13.21 13 122031 108 64376580
Encephalitis 39.62 13.21 79 121965 12492 64364196
Weight decreased 39.49 13.21 348 121696 285391 64091297
Gastrointestinal necrosis 39.48 13.21 48 121996 4944 64371744
Abscess bacterial 39.42 13.21 22 122022 739 64375949
Ganglioneuroblastoma 39.42 13.21 10 122034 28 64376660
Therapy non-responder 39.31 13.21 236 121808 65663 64311025
Lennox-Gastaut syndrome 39.05 13.21 15 122029 207 64376481
Liver function test abnormal 38.98 13.21 33 122011 59368 64317320
Nephrolithiasis 38.79 13.21 17 122027 43666 64333022
Epstein-Barr viraemia 38.72 13.21 30 122014 1767 64374921
COVID-19 38.67 13.21 233 121811 64907 64311781
Pseudomonal bacteraemia 38.60 13.21 33 122011 2236 64374452
Unevaluable event 38.40 13.21 24 122020 50465 64326223
Cerebral aspergillosis 38.10 13.21 29 122015 1664 64375024
Wrong technique in product usage process 38.06 13.21 40 122004 64934 64311754
Acute monocytic leukaemia 38.04 13.21 18 122026 425 64376263
Autoimmune lymphoproliferative syndrome 37.99 13.21 14 122030 171 64376517
Rhabdomyosarcoma recurrent 37.64 13.21 12 122032 91 64376597
Xanthogranuloma 37.59 13.21 11 122033 60 64376628
Osteomyelitis bacterial 37.36 13.21 18 122026 443 64376245
Nervous system disorder 37.18 13.21 112 121932 22966 64353722
Adenoviral hepatitis 37.10 13.21 18 122026 450 64376238
Pulmonary arteriopathy 37.08 13.21 12 122032 96 64376592
Haemolysis 36.77 13.21 71 121973 10968 64365720
Dry mouth 36.75 13.21 36 122008 60382 64316306
Delayed puberty 36.67 13.21 13 122031 141 64376547
Combined immunodeficiency 36.65 13.21 12 122032 100 64376588
Lymphoid tissue hypoplasia 36.28 13.21 18 122026 473 64376215
B-cell lymphoma refractory 36.14 13.21 12 122032 105 64376583
Neuroleptic malignant syndrome 36.03 13.21 3 122041 24993 64351695
Enteritis 35.82 13.21 74 121970 12003 64364685
Joint stiffness 35.80 13.21 7 122037 30397 64346291
Nasal congestion 35.77 13.21 36 122008 59622 64317066
Klebsiella bacteraemia 35.72 13.21 32 122012 2308 64374380
Adverse event 35.65 13.21 15 122029 39474 64337214
Coronavirus infection 35.59 13.21 48 121996 5482 64371206
Hepatic candidiasis 35.51 13.21 11 122033 75 64376613
Gastrointestinal toxicity 35.48 13.21 47 121997 5275 64371413
Lymphocytosis 35.48 13.21 39 122005 3605 64373083
Amnesia 35.28 13.21 24 122020 48245 64328443
Body temperature decreased 35.04 13.21 4 122040 25924 64350764
Vertigo 34.93 13.21 36 122008 58975 64317713
Mucosal infection 34.93 13.21 17 122027 428 64376260
Temporal lobe epilepsy 34.68 13.21 16 122028 356 64376332
Eczema 34.66 13.21 7 122037 29713 64346975
Sopor 34.56 13.21 7 122037 29654 64347034
Venous thrombosis 34.56 13.21 51 121993 6330 64370358
Restlessness 34.52 13.21 16 122028 39769 64336919
Osteosarcoma 34.40 13.21 15 122029 291 64376397
Enterocolitis infectious 34.30 13.21 32 122012 2432 64374256
Meningitis cryptococcal 34.26 13.21 35 122009 2974 64373714
Chronic myelomonocytic leukaemia 34.21 13.21 20 122024 735 64375953
Soft tissue infection 34.02 13.21 36 122008 3187 64373501
Jugular vein thrombosis 33.88 13.21 39 122005 3792 64372896
Ileus 33.79 13.21 108 121936 22858 64353830
Cholestasis 33.66 13.21 171 121873 44701 64331987
C-reactive protein abnormal 33.55 13.21 7 122037 29040 64347648
Lipase increased 33.42 13.21 80 121964 14322 64362366
Limb injury 33.39 13.21 3 122041 23502 64353186
Withdrawal syndrome 33.37 13.21 3 122041 23489 64353199
Localised infection 33.36 13.21 8 122036 30153 64346535
Orthostatic hypotension 33.15 13.21 24 122020 46714 64329974
Hepatic infection fungal 33.11 13.21 13 122031 191 64376497
Influenza 32.94 13.21 98 121946 106433 64270255
Abdominal neoplasm 32.69 13.21 16 122028 408 64376280
Chronic myeloid leukaemia 32.66 13.21 36 122008 3338 64373350
Acne 32.65 13.21 3 122041 23078 64353610
Drug clearance decreased 32.65 13.21 32 122012 2587 64374101
Myelitis transverse 32.61 13.21 26 122018 1597 64375091
Electrocardiogram QT prolonged 32.57 13.21 63 121981 79385 64297303
Staphylococcal infection 32.49 13.21 185 121859 50493 64326195
Joint injury 32.41 13.21 3 122041 22944 64353744
Transverse sinus thrombosis 32.33 13.21 18 122026 602 64376086
Medulloblastoma recurrent 32.28 13.21 11 122033 105 64376583
Hyperammonaemia 32.13 13.21 63 121981 9841 64366847
Central nervous system enteroviral infection 32.06 13.21 10 122034 70 64376618
Babesiosis 32.04 13.21 14 122030 273 64376415
Hyperkalaemia 32.02 13.21 92 121952 101037 64275651
Lower respiratory tract infection fungal 31.91 13.21 20 122024 835 64375853
Visual impairment 31.91 13.21 57 121987 74020 64302668
Norovirus test positive 31.75 13.21 16 122028 435 64376253
Abnormal behaviour 31.61 13.21 12 122032 33610 64343078
Necrotising gastritis 31.58 13.21 10 122034 74 64376614
B-cell lymphoma 31.57 13.21 45 121999 5412 64371276
Hypoalbuminaemia 31.57 13.21 89 121955 17585 64359103
Retinal haemorrhage 31.57 13.21 53 121991 7345 64369343
B precursor type acute leukaemia 31.49 13.21 14 122030 285 64376403
Haematochezia 31.45 13.21 48 121996 66325 64310363
Chronic kidney disease 31.37 13.21 38 122006 57881 64318807
Nail pigmentation 31.35 13.21 14 122030 288 64376400
Disseminated cryptococcosis 31.27 13.21 25 122019 1542 64375146
Dysgeusia 31.04 13.21 26 122018 47021 64329667
Leukaemic lymphoma 30.79 13.21 10 122034 81 64376607
Femur fracture 30.76 13.21 13 122031 34122 64342566
Nephroblastoma 30.71 13.21 7 122037 10 64376678
Toxic neuropathy 30.67 13.21 19 122025 777 64375911
Klebsiella sepsis 30.67 13.21 31 122013 2601 64374087
Skin exfoliation 30.62 13.21 24 122020 44861 64331827
Oesophageal stenosis 30.54 13.21 37 122007 3797 64372891
Atypical haemolytic uraemic syndrome 30.49 13.21 18 122026 674 64376014
Leukoerythroblastosis 30.35 13.21 13 122031 241 64376447
Viral load increased 30.28 13.21 30 122014 2457 64374231
Acute biphenotypic leukaemia 30.10 13.21 11 122033 131 64376557
Pneumonia cytomegaloviral 29.98 13.21 39 122005 4300 64372388
Capillary leak syndrome 29.89 13.21 34 122010 3263 64373425
Paraparesis 29.88 13.21 35 122009 3467 64373221
Central nervous system neoplasm 29.86 13.21 10 122034 90 64376598
Central nervous system fungal infection 29.80 13.21 15 122029 407 64376281
Cystitis bacterial 29.76 13.21 15 122029 408 64376280
Respiratory tract infection fungal 29.76 13.21 21 122023 1071 64375617
Acute lung injury 29.71 13.21 31 122013 2700 64373988
Leukaemia cutis 29.59 13.21 11 122033 138 64376550
Rib fracture 29.45 13.21 5 122039 24033 64352655
Tumour necrosis 29.37 13.21 25 122019 1684 64375004
Stevens-Johnson syndrome 29.36 13.21 14 122030 34235 64342453
Skin discolouration 29.34 13.21 15 122029 35240 64341448
Transformation to acute myeloid leukaemia 29.30 13.21 19 122025 842 64375846
Erythropoiesis abnormal 29.20 13.21 15 122029 425 64376263
Tooth disorder 28.95 13.21 4 122040 22398 64354290
Premature menopause 28.93 13.21 16 122028 528 64376160
Gastrointestinal inflammation 28.62 13.21 46 121998 6149 64370539
Histiocytic sarcoma 28.61 13.21 9 122035 65 64376623
Streptococcus test positive 28.48 13.21 26 122018 1922 64374766
Metastases to bone marrow 28.45 13.21 17 122027 651 64376037
Iris atrophy 28.41 13.21 10 122034 106 64376582
Therapy cessation 28.29 13.21 13 122031 32476 64344212
Geotrichum infection 28.19 13.21 19 122025 899 64375789
Gastric disorder 28.16 13.21 10 122034 29187 64347501
White blood cell count abnormal 28.04 13.21 40 122004 4814 64371874
Viraemia 27.98 13.21 28 122016 2321 64374367
Refractory cancer 27.94 13.21 12 122032 224 64376464
Toxicity to various agents 27.87 13.21 502 121542 363011 64013677
Epstein Barr virus positive mucocutaneous ulcer 27.78 13.21 17 122027 680 64376008
Skin toxicity 27.77 13.21 47 121997 6555 64370133
Sciatica 27.71 13.21 3 122041 20261 64356427
Product quality issue 27.42 13.21 11 122033 29788 64346900
Transient ischaemic attack 27.25 13.21 26 122018 44156 64332532
Hyperglycaemia 27.11 13.21 203 121841 60765 64315923
Escherichia test positive 27.10 13.21 30 122014 2795 64373893
Heart rate abnormal 26.92 13.21 40 122004 4995 64371693
Ureaplasma infection 26.89 13.21 17 122027 721 64375967
Device dislocation 26.86 13.21 4 122040 21174 64355514
Oedema 26.71 13.21 87 121957 91848 64284840
Carotid intima-media thickness increased 26.59 13.21 9 122035 84 64376604
Subclavian vein thrombosis 26.50 13.21 27 122017 2287 64374401
Ameloblastoma 26.49 13.21 9 122035 85 64376603
Mediastinum neoplasm 26.49 13.21 9 122035 85 64376603
Neurological decompensation 26.28 13.21 37 122007 4399 64372289
Vocal cord paresis 25.98 13.21 11 122033 198 64376490
Cellulitis gangrenous 25.97 13.21 12 122032 268 64376420
Illness 25.93 13.21 5 122039 21933 64354755
B-cell type acute leukaemia 25.88 13.21 14 122030 442 64376246
Encephalitis enteroviral 25.71 13.21 10 122034 143 64376545
Renal tubular disorder 25.69 13.21 43 122001 5944 64370744
Colitis ulcerative 25.68 13.21 6 122038 23022 64353666
Epidermal necrosis 25.66 13.21 21 122023 1339 64375349
Throat irritation 25.64 13.21 15 122029 32696 64343992
Haematopoietic stem cell mobilisation 25.63 13.21 11 122033 205 64376483
Renal replacement therapy 25.59 13.21 10 122034 145 64376543
Helicobacter infection 25.55 13.21 21 122023 38341 64338347
Bacillus test positive 25.52 13.21 9 122035 96 64376592
Eye pain 25.51 13.21 14 122030 31611 64345077
Tendonitis 25.34 13.21 4 122040 20278 64356410
Blood bilirubin increased 25.24 13.21 191 121853 57362 64319326
Cytomegalovirus colitis 25.13 13.21 34 122010 3894 64372794
Depressed level of consciousness 25.11 13.21 75 121969 81361 64295327
Device issue 25.06 13.21 6 122038 22642 64354046
Hip arthroplasty 24.96 13.21 5 122039 21346 64355342
Meningitis tuberculous 24.93 13.21 19 122025 1092 64375596
Myelitis 24.82 13.21 25 122019 2089 64374599
Marginal zone lymphoma recurrent 24.77 13.21 7 122037 33 64376655
Intestinal atresia 24.72 13.21 8 122036 64 64376624
Blood creatinine increased 24.66 13.21 153 121891 135629 64241059
Metastases to spleen 24.51 13.21 14 122030 492 64376196
Blood pressure diastolic decreased 24.50 13.21 6 122038 22295 64354393
Faeces discoloured 24.50 13.21 9 122035 25720 64350968
Cerebral salt-wasting syndrome 24.49 13.21 9 122035 109 64376579
Peripheral T-cell lymphoma unspecified 24.47 13.21 15 122029 602 64376086
Hypersomnia 24.38 13.21 4 122040 19713 64356975
Listeria sepsis 24.38 13.21 15 122029 606 64376082
Panic attack 24.30 13.21 5 122039 20948 64355740
Infusion related reaction 24.18 13.21 197 121847 164270 64212418
Swelling face 24.18 13.21 47 121997 59119 64317569
Hepatitis B DNA increased 24.18 13.21 15 122029 615 64376073
Tracheo-oesophageal fistula 24.13 13.21 14 122030 507 64376181
Dyspnoea exertional 24.13 13.21 66 121978 73664 64303024
Hypoaesthesia 24.12 13.21 159 121885 138949 64237739
Blood HIV RNA increased 24.06 13.21 21 122023 1463 64375225
Foot fracture 24.05 13.21 3 122041 18154 64358534
Stomatococcal infection 24.04 13.21 11 122033 240 64376448
Myeloproliferative neoplasm 24.01 13.21 17 122027 872 64375816
Trichosporon infection 23.96 13.21 17 122027 875 64375813
Herpes simplex encephalitis 23.94 13.21 15 122029 626 64376062
Platelet count abnormal 23.92 13.21 34 122010 4078 64372610
Jejunal stenosis 23.89 13.21 8 122036 72 64376616
Acute myocardial infarction 23.89 13.21 61 121983 69657 64307031
Lower respiratory tract infection 23.86 13.21 95 121949 94519 64282169
Disorder of orbit 23.85 13.21 9 122035 118 64376570
Subacute combined cord degeneration 23.82 13.21 12 122032 326 64376362
Diffuse alveolar damage 23.81 13.21 30 122014 3205 64373483
Optic glioma 23.80 13.21 7 122037 39 64376649
Ankle brachial index decreased 23.79 13.21 8 122036 73 64376615
Pulse waveform abnormal 23.60 13.21 8 122036 75 64376613
Abortion spontaneous 23.60 13.21 9 122035 25134 64351554
Administration related reaction 23.58 13.21 9 122035 122 64376566
Sputum discoloured 23.53 13.21 3 122041 17853 64358835
Blood potassium decreased 23.51 13.21 25 122019 40374 64336314
Kidney infection 23.50 13.21 3 122041 17835 64358853
Sinusitis fungal 23.45 13.21 22 122022 1684 64375004
Hip fracture 23.35 13.21 11 122033 27088 64349600
Hepatitis 23.31 13.21 157 121887 45425 64331263
Cerebellar stroke 23.21 13.21 13 122031 440 64376248
Dry eye 23.19 13.21 13 122031 29006 64347682
Pharyngeal inflammation 23.17 13.21 17 122027 922 64375766
Cardiac dysfunction 23.17 13.21 29 122015 3077 64373611
Neutrophil count abnormal 23.15 13.21 28 122016 2868 64373820
Molluscum contagiosum 23.07 13.21 13 122031 445 64376243
Blindness cortical 23.01 13.21 16 122028 797 64375891
Diabetic ketoacidosis 22.95 13.21 14 122030 29831 64346857
Retroperitoneal lymphadenopathy 22.93 13.21 17 122027 937 64375751
Herpes zoster meningoencephalitis 22.93 13.21 15 122029 675 64376013
Migraine 22.93 13.21 53 121991 62624 64314064
Renal salt-wasting syndrome 22.92 13.21 13 122031 451 64376237
Cough 22.91 13.21 418 121626 301730 64074958
Paranasal sinus mucosal hypertrophy 22.88 13.21 8 122036 83 64376605
Gastric pneumatosis 22.87 13.21 6 122038 20 64376668
Lymphocytic leukaemia 22.84 13.21 10 122034 196 64376492
Positron emission tomogram abnormal 22.82 13.21 11 122033 271 64376417
Pleocytosis 22.81 13.21 18 122026 1089 64375599
Respiratory depression 22.66 13.21 8 122036 23435 64353253
Retinal pigment epitheliopathy 22.65 13.21 12 122032 363 64376325
Ear infection 22.60 13.21 8 122036 23396 64353292
Aspiration bone marrow abnormal 22.57 13.21 9 122035 138 64376550
Neurofibrosarcoma 22.52 13.21 10 122034 203 64376485
Emotional distress 22.47 13.21 21 122023 36017 64340671
Tissue infiltration 22.46 13.21 14 122030 579 64376109
Transaminases increased 22.45 13.21 153 121891 44441 64332247
Anorectal cellulitis 22.38 13.21 8 122036 89 64376599
Cerebral thrombosis 22.37 13.21 24 122020 2158 64374530
Metapneumovirus infection 22.34 13.21 20 122024 1441 64375247
Aggression 22.32 13.21 33 122011 46199 64330489
Dehydration 22.20 13.21 283 121761 216480 64160208
Red blood cell sedimentation rate increased 22.20 13.21 16 122028 31219 64345469
Disturbance in attention 22.18 13.21 27 122017 41047 64335641
Pregnancy 22.18 13.21 6 122038 20859 64355829
Encephalitis cytomegalovirus 22.14 13.21 17 122027 988 64375700
Autonomic neuropathy 22.13 13.21 21 122023 1631 64375057
Taeniasis 22.08 13.21 7 122037 52 64376636
Erythropenia 22.06 13.21 12 122032 383 64376305
Loss of CAR T-cell persistence 22.02 13.21 6 122038 24 64376664
Bone marrow infiltration 21.96 13.21 13 122031 489 64376199
Therapeutic response delayed 21.84 13.21 16 122028 866 64375822
Blood potassium increased 21.70 13.21 11 122033 25969 64350719
T-cell type acute leukaemia 21.62 13.21 9 122035 155 64376533
Intracardiac thrombus 21.61 13.21 31 122013 3750 64372938
Sphingomonas paucimobilis infection 21.54 13.21 8 122036 100 64376588
Traumatic lung injury 21.54 13.21 24 122020 2252 64374436
Delusion 21.52 13.21 4 122040 18010 64358678
Device related thrombosis 21.50 13.21 23 122021 2062 64374626
Cryptococcal fungaemia 21.46 13.21 9 122035 158 64376530
Administration site extravasation 21.35 13.21 17 122027 1042 64375646
Papillary thyroid cancer 21.35 13.21 24 122020 2274 64374414
Ocular hyperaemia 21.30 13.21 8 122036 22556 64354132
Microgenia 21.23 13.21 5 122039 9 64376679
Microsporidia infection 21.17 13.21 15 122029 770 64375918
Bacterial translocation 21.03 13.21 12 122032 421 64376267
Hepatitis B surface antigen positive 20.96 13.21 9 122035 168 64376520
Basal cell naevus syndrome 20.94 13.21 6 122038 30 64376658
Brain oedema 20.87 13.21 90 121954 21985 64354703
Retinopathy proliferative 20.85 13.21 8 122036 110 64376578
Neuroborreliosis 20.85 13.21 8 122036 110 64376578
Chronic hepatitis 20.67 13.21 18 122026 1250 64375438
Muscle rigidity 20.62 13.21 4 122040 17469 64359219
Primary immunodeficiency syndrome 20.52 13.21 7 122037 67 64376621
Intestinal pseudo-obstruction 20.51 13.21 22 122022 1978 64374710
Neurological symptom 20.28 13.21 42 122002 6822 64369866
Chloroma 20.25 13.21 14 122030 691 64375997
Nephropathy toxic 20.23 13.21 76 121968 17438 64359250
Refractory cytopenia with multilineage dysplasia 20.22 13.21 10 122034 261 64376427
Diverticulitis 20.21 13.21 26 122018 38592 64338096
Suspected product quality issue 20.11 13.21 10 122034 264 64376424
Extrapyramidal disorder 20.09 13.21 6 122038 19546 64357142
Extramedullary haemopoiesis 19.98 13.21 8 122036 124 64376564
Blood immunoglobulin G decreased 19.93 13.21 25 122019 2658 64374030
Metastases to retroperitoneum 19.92 13.21 11 122033 362 64376326
Injection site rash 19.90 13.21 3 122041 15739 64360949
Bone marrow necrosis 19.86 13.21 9 122035 192 64376496
Splenic candidiasis 19.82 13.21 7 122037 75 64376613
Photosensitivity reaction 19.75 13.21 5 122039 18168 64358520
Delirium 19.74 13.21 66 121978 69128 64307560
Pneumoperitoneum 19.73 13.21 25 122019 2686 64374002
Congenital herpes simplex infection 19.71 13.21 5 122039 14 64376674
Rhinocerebral mucormycosis 19.68 13.21 12 122032 477 64376211
Blood calcium decreased 19.64 13.21 12 122032 25542 64351146
Hydrocephalus 19.63 13.21 44 122000 7547 64369141
Exposure during pregnancy 19.58 13.21 78 121966 77597 64299091
Astrocytoma 19.52 13.21 9 122035 200 64376488
Hypophagia 19.44 13.21 135 121909 39452 64337236
Lung opacity 19.43 13.21 27 122017 3172 64373516
Accidental exposure to product 19.41 13.21 13 122031 26351 64350337
Osteoporosis 19.39 13.21 31 122013 42049 64334639
Hepatitis viral 19.27 13.21 15 122029 890 64375798
Meningoencephalitis viral 19.22 13.21 11 122033 388 64376300
Rectal fissure 19.22 13.21 14 122030 751 64375937
Splenomegaly 19.16 13.21 76 121968 17885 64358803
Small intestinal perforation 19.10 13.21 24 122020 2556 64374132
Listeriosis 19.03 13.21 21 122023 1949 64374739
Basal ganglion degeneration 19.00 13.21 11 122033 397 64376291
Metastases to meninges 18.98 13.21 25 122019 2790 64373898
Premature ageing 18.96 13.21 7 122037 86 64376602
Uterine enlargement 18.96 13.21 14 122030 767 64375921
Liver tenderness 18.95 13.21 10 122034 300 64376388
Paraplegia 18.94 13.21 32 122012 4458 64372230
Chromosome analysis abnormal 18.93 13.21 9 122035 215 64376473
Plasminogen decreased 18.86 13.21 4 122040 3 64376685
Haemolytic uraemic syndrome 18.77 13.21 30 122014 3991 64372697
Vascular access complication 18.74 13.21 16 122028 1082 64375606
Pneumonia aspiration 18.70 13.21 54 121990 59217 64317471
Growth failure 18.70 13.21 9 122035 221 64376467
Flatulence 18.68 13.21 24 122020 35642 64341046
Fungal oesophagitis 18.67 13.21 14 122030 785 64375903
Intracranial pressure increased 18.62 13.21 41 122003 6948 64369740
Hepatic amoebiasis 18.60 13.21 7 122037 91 64376597
Urinary bladder rupture 18.60 13.21 7 122037 91 64376597
Disseminated aspergillosis 18.56 13.21 13 122031 655 64376033
Obliterative bronchiolitis 18.49 13.21 24 122020 2641 64374047
Metastases to muscle 18.47 13.21 10 122034 316 64376372
Alveolar soft part sarcoma 18.47 13.21 7 122037 93 64376595
Lymphoproliferative disorder 18.46 13.21 34 122010 5069 64371619
Respiratory tract congestion 18.45 13.21 4 122040 16161 64360527
Rash macular 18.37 13.21 11 122033 23674 64353014
Feeling cold 18.36 13.21 11 122033 23667 64353021
Candida endophthalmitis 18.35 13.21 8 122036 155 64376533
Vagus nerve paralysis 18.35 13.21 5 122039 20 64376668
Thrombocytopenia neonatal 18.35 13.21 5 122039 20 64376668
Mental disorder 18.21 13.21 14 122030 26431 64350257
Accidental overdose 18.19 13.21 22 122022 33535 64343153
Helicobacter sepsis 18.16 13.21 5 122039 21 64376667
Breast cancer 18.15 13.21 17 122027 29131 64347557
Apraxia 18.14 13.21 23 122021 2472 64374216
Splenic necrosis 18.07 13.21 7 122037 99 64376589
Right ventricular failure 18.07 13.21 9 122035 21462 64355226
Hypertensive crisis 18.03 13.21 6 122038 18242 64358446
Feeding intolerance 17.95 13.21 12 122032 560 64376128
Rash erythematous 17.89 13.21 41 122003 48592 64328096
Gait inability 17.89 13.21 33 122011 42335 64334353
Acute hepatic failure 17.85 13.21 97 121947 26015 64350673
Streptococcal infection 17.84 13.21 42 122002 7437 64369251
Haematocrit decreased 17.83 13.21 49 121995 54606 64322082
Haematoma 17.82 13.21 38 122006 46212 64330476
Plasma cell myeloma refractory 17.82 13.21 7 122037 103 64376585
Splenic marginal zone lymphoma 17.79 13.21 5 122039 23 64376665
Growth hormone deficiency 17.78 13.21 10 122034 341 64376347
Splenic infection fungal 17.76 13.21 7 122037 104 64376584
Hypertension 17.72 13.21 365 121679 258896 64117792
Human polyomavirus infection 17.70 13.21 15 122029 1004 64375684
Peritonitis viral 17.63 13.21 6 122038 57 64376631
Brain injury 17.62 13.21 50 121994 9915 64366773
Chronic hepatitis B 17.59 13.21 9 122035 253 64376435
Candida pneumonia 17.58 13.21 11 122033 458 64376230
Eating disorder 17.55 13.21 5 122039 16800 64359888
Disorientation 17.51 13.21 51 121993 55777 64320911
Therapy interrupted 17.47 13.21 8 122036 20028 64356660
Proteinuria 17.46 13.21 16 122028 27707 64348981
Labelled drug-drug interaction medication error 17.46 13.21 10 122034 22052 64354636
Encephalitis viral 17.40 13.21 22 122022 2358 64374330
Product administration error 17.36 13.21 16 122028 27627 64349061
Cutaneous T-cell lymphoma recurrent 17.36 13.21 6 122038 60 64376628
Vulvovaginal inflammation 17.34 13.21 11 122033 469 64376219
Angina unstable 17.31 13.21 4 122040 15463 64361225
Thirst 17.19 13.21 3 122041 14134 64362554
Humoral immune defect 17.17 13.21 7 122037 114 64376574
Fracture 17.13 13.21 7 122037 18748 64357940
Pneumothorax spontaneous 17.11 13.21 15 122029 1051 64375637
Neuralgia 17.06 13.21 96 121948 26088 64350600
Cardiomegaly 17.01 13.21 12 122032 23672 64353016
Facial paresis 16.95 13.21 32 122012 4860 64371828
Pulmonary haemorrhage 16.93 13.21 59 121985 13050 64363638
Pericarditis 16.91 13.21 61 121983 62455 64314233
Vulvovaginitis 16.90 13.21 9 122035 275 64376413
Chronic lymphocytic leukaemia refractory 16.90 13.21 7 122037 119 64376569
Haemoglobin abnormal 16.88 13.21 36 122008 5968 64370720
Spinal stenosis 16.84 13.21 3 122041 13928 64362760
Musculoskeletal discomfort 16.71 13.21 5 122039 16272 64360416
Infection parasitic 16.71 13.21 10 122034 384 64376304
Pneumaturia 16.69 13.21 5 122039 30 64376658
Granulocyte count decreased 16.67 13.21 16 122028 1260 64375428
Otitis media acute 16.64 13.21 15 122029 1091 64375597
VIth nerve paralysis 16.60 13.21 17 122027 1449 64375239
Fanconi syndrome 16.54 13.21 22 122022 2479 64374209
Coronavirus test positive 16.52 13.21 14 122030 937 64375751
Blood urine present 16.50 13.21 7 122037 18333 64358355
Primary mediastinal large B-cell lymphoma recurrent 16.45 13.21 6 122038 71 64376617
Morphoea 16.43 13.21 10 122034 396 64376292
Primitive neuroectodermal tumour 16.41 13.21 5 122039 32 64376656
Diabetes mellitus inadequate control 16.40 13.21 10 122034 21311 64355377
Pulmonary sarcoidosis 16.35 13.21 15 122029 1116 64375572
Coma 16.28 13.21 98 121946 87517 64289171
Restless legs syndrome 16.27 13.21 6 122038 17110 64359578
Blood glucose decreased 16.23 13.21 12 122032 23111 64353577
Gastroenteritis norovirus 16.23 13.21 23 122021 2752 64373936
Blastic plasmacytoid dendritic cell neoplasia 16.09 13.21 6 122038 76 64376612
Flagellate dermatitis 16.06 13.21 8 122036 212 64376476
Disseminated cytomegaloviral infection 16.01 13.21 10 122034 415 64376273
Cellulitis orbital 15.97 13.21 12 122032 675 64376013
Genotoxicity 15.91 13.21 5 122039 36 64376652
Hiatus hernia 15.86 13.21 9 122035 19948 64356740
Acute respiratory distress syndrome 15.84 13.21 127 121917 38808 64337880
Haemangioma-thrombocytopenia syndrome 15.82 13.21 3 122041 0 64376688
Non-alcoholic steatohepatitis 15.81 13.21 19 122025 1933 64374755
Mass 15.78 13.21 64 121980 15212 64361476
Streptococcal sepsis 15.76 13.21 21 122023 2371 64374317
Miosis 15.73 13.21 3 122041 13263 64363425
Bone disorder 15.72 13.21 6 122038 16753 64359935
Alanine aminotransferase increased 15.72 13.21 359 121685 138672 64238016
Diverticulum 15.62 13.21 3 122041 13195 64363493
Creatinine renal clearance decreased 15.61 13.21 4 122040 14417 64362271
Paratracheal lymphadenopathy 15.59 13.21 7 122037 146 64376542
Metapneumovirus bronchiolitis 15.57 13.21 4 122040 12 64376676
Personality change due to a general medical condition 15.54 13.21 7 122037 147 64376541
Intervertebral disc degeneration 15.49 13.21 3 122041 13117 64363571
Human metapneumovirus test positive 15.46 13.21 7 122037 149 64376539
Lewis-Sumner syndrome 15.45 13.21 5 122039 40 64376648
T-cell prolymphocytic leukaemia 15.45 13.21 5 122039 40 64376648
Adenocarcinoma gastric 15.41 13.21 17 122027 1578 64375110
Sinus congestion 15.39 13.21 5 122039 15434 64361254
Drug eruption 15.38 13.21 28 122016 36108 64340580
Gastrointestinal haemorrhage 15.37 13.21 168 121876 132144 64244544
Candida sepsis 15.36 13.21 20 122024 2208 64374480
Chromosomal deletion 15.35 13.21 6 122038 87 64376601
Antithrombin III 15.35 13.21 6 122038 87 64376601
Melaena 15.32 13.21 51 121993 53497 64323191
Agitation 15.31 13.21 101 121943 88266 64288422
Gastrointestinal disorder 15.31 13.21 103 121941 89606 64287082
Partial seizures 15.27 13.21 39 122005 7268 64369420
Perirectal abscess 15.27 13.21 18 122026 1795 64374893
Mononeuropathy multiplex 15.22 13.21 9 122035 338 64376350
Hepatic haemorrhage 15.18 13.21 13 122031 883 64375805
Leukaemic infiltration extramedullary 15.16 13.21 7 122037 156 64376532
Glaucoma 15.10 13.21 6 122038 16342 64360346
Superior vena cava syndrome 15.04 13.21 14 122030 1061 64375627
Aborted pregnancy 14.93 13.21 5 122039 45 64376643
Human herpesvirus 7 infection 14.93 13.21 6 122038 94 64376594
Bone sarcoma 14.87 13.21 6 122038 95 64376593
Blood urea increased 14.84 13.21 39 122005 44114 64332574
Coronary artery occlusion 14.76 13.21 4 122040 13887 64362801
Pneumonia klebsiella 14.73 13.21 27 122017 4010 64372678
Metastasis 14.71 13.21 33 122011 5662 64371026
Metastases to lymph nodes 14.70 13.21 43 122001 8674 64368014
Cholelithiasis 14.69 13.21 41 122003 45465 64331223
Beta 2 microglobulin decreased 14.68 13.21 4 122040 16 64376672
Anal ulcer 14.67 13.21 14 122030 1095 64375593
Crying 14.66 13.21 10 122034 20080 64356608
Enteral nutrition 14.65 13.21 5 122039 48 64376640
Hypertransaminasaemia 14.64 13.21 38 122006 7153 64369535
Ageusia 14.63 13.21 4 122040 13809 64362879
Campylobacter gastroenteritis 14.59 13.21 14 122030 1102 64375586
Axonal neuropathy 14.59 13.21 17 122027 1675 64375013
Enterovesical fistula 14.55 13.21 13 122031 934 64375754
Poisoning 14.54 13.21 12 122032 21867 64354821
Cystitis viral 14.51 13.21 11 122033 627 64376061
Therapeutic response unexpected 14.50 13.21 7 122037 16994 64359694
Tachypnoea 14.48 13.21 93 121951 26478 64350210
Streptococcal bacteraemia 14.48 13.21 23 122021 3044 64373644
Rectal haemorrhage 14.39 13.21 64 121980 61753 64314935
Eye irritation 14.35 13.21 6 122038 15850 64360838
White matter lesion 14.34 13.21 17 122027 1705 64374983
Adenoviral haemorrhagic cystitis 14.33 13.21 10 122034 501 64376187
Herpes simplex reactivation 14.33 13.21 8 122036 269 64376419
Retinal toxicity 14.29 13.21 15 122029 1315 64375373
Bronchospasm 14.28 13.21 12 122032 21670 64355018
Hepatic infarction 14.18 13.21 12 122032 802 64375886
Neoplasm 14.15 13.21 37 122007 6994 64369694
Vasogenic cerebral oedema 14.14 13.21 13 122031 970 64375718
Ventricular dysfunction 14.14 13.21 31 122013 5239 64371449
Antithrombin III deficiency 14.12 13.21 6 122038 109 64376579
Eosinophilia 14.08 13.21 32 122012 38044 64338644
SARS-CoV-2 test negative 14.07 13.21 10 122034 516 64376172
Bacillus bacteraemia 14.02 13.21 6 122038 111 64376577
Rhinorrhoea 14.01 13.21 62 121982 59907 64316781
Paraesthesia 14.00 13.21 175 121869 134347 64242341
Myocardial ischaemia 13.97 13.21 14 122030 23237 64353451
Malignant neoplasm of orbit 13.96 13.21 4 122040 20 64376668
Acinetobacter sepsis 13.96 13.21 5 122039 56 64376632
Speech disorder 13.95 13.21 46 121998 48395 64328293
Underdose 13.93 13.21 17 122027 25812 64350876
Klebsiella test positive 13.93 13.21 15 122029 1355 64375333
Cataract 13.87 13.21 50 121994 51212 64325476
Eye swelling 13.87 13.21 13 122031 22268 64354420
Pharyngeal oedema 13.86 13.21 6 122038 15525 64361163
Throat tightness 13.85 13.21 14 122030 23146 64353542
Hypouricaemia 13.84 13.21 9 122035 401 64376287
Staphylococcus test positive 13.80 13.21 32 122012 5613 64371075
Duodenal stenosis 13.78 13.21 11 122033 677 64376011
Ovarian failure 13.75 13.21 10 122034 535 64376153
Ataxia telangiectasia 13.74 13.21 3 122041 3 64376685
Cold sweat 13.69 13.21 7 122037 16448 64360240
Anaplastic lymphoma kinase gene mutation 13.68 13.21 6 122038 118 64376570
Stomatitis necrotising 13.67 13.21 7 122037 197 64376491
Seizure 13.67 13.21 413 121631 166479 64210209
Anaesthesia 13.66 13.21 9 122035 410 64376278
Philadelphia positive acute lymphocytic leukaemia 13.65 13.21 5 122039 60 64376628
Endocrine disorder 13.64 13.21 11 122033 687 64376001
Ulcer 13.63 13.21 14 122030 22976 64353712
Pyloric stenosis 13.62 13.21 9 122035 412 64376276
Transplant rejection 13.61 13.21 8 122036 17393 64359295
Skin cancer 13.59 13.21 3 122041 11971 64364717
Graft versus host disease 13.58 13.21 57 121987 13756 64362932
Listeria encephalitis 13.51 13.21 8 122036 301 64376387
Sinus bradycardia 13.51 13.21 14 122030 22879 64353809
Blood pressure diastolic abnormal 13.50 13.21 3 122041 11914 64364774
Potentiating drug interaction 13.50 13.21 39 122005 7813 64368875
Lactic acidosis 13.45 13.21 65 121979 61345 64315343
Post-acute COVID-19 syndrome 13.43 13.21 5 122039 63 64376625
Pancreatitis acute 13.42 13.21 132 121912 42723 64333965
Abdominal mass 13.40 13.21 22 122022 2993 64373695
Impaired work ability 13.39 13.21 6 122038 15213 64361475
Tuberculosis liver 13.36 13.21 5 122039 64 64376624
Oxygen saturation decreased 13.29 13.21 134 121910 107042 64269646
Cerebral hypoperfusion 13.29 13.21 11 122033 713 64375975
Haemorrhage intracranial 13.27 13.21 84 121960 23800 64352888
Blood alkaline phosphatase increased 13.26 13.21 58 121986 56221 64320467
Dermatitis allergic 13.22 13.21 6 122038 15103 64361585
Infective thrombosis 13.22 13.21 5 122039 66 64376622
Procedural pneumothorax 13.22 13.21 5 122039 66 64376622

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01CA02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Vinca alkaloids and analogues
FDA CS M0022674 Vinca Alkaloids
FDA EPC N0000175612 Vinca Alkaloid
MeSH PA D050256 Antimitotic Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000972 Antineoplastic Agents, Phytogenic
MeSH PA D050257 Tubulin Modulators
CHEBI has role CHEBI:23888 drugs
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:60832 tubulin modulators
CHEBI has role CHEBI:61951 microtubule destabilizing role
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:176497 geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acute lymphoid leukemia indication 91857003 DOID:9952
Diffuse non-Hodgkin's lymphoma, large cell indication 109969005
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Rhabdomyosarcoma indication 302847003 DOID:3247
Nephroblastoma indication 302849000 DOID:2154
Follicular non-Hodgkin's lymphoma indication 308121000
Neuroblastoma indication 432328008 DOID:769
Astrocytoma, anaplastic off-label use 55353007 DOID:3078
Ewing's sarcoma off-label use 76909002 DOID:3369
Chronic lymphoid leukemia, disease off-label use 92814006
Multiple myeloma off-label use 109989006 DOID:9538
Mycosis fungoides off-label use 118618005
Small cell carcinoma of lung off-label use 254632001 DOID:5409
Glioblastoma multiforme of brain off-label use 276828006 DOID:3073
Primary cutaneous T-cell lymphoma off-label use 400122007
Ovarian Germ Cell Tumor Carcinoma off-label use
Mycosis contraindication 3218000 DOID:1564
Hyperbilirubinemia contraindication 14783006 DOID:2741
Obstruction of bile duct contraindication 30144000
Viral disease contraindication 34014006 DOID:934
Hyperuricemia contraindication 35885006 DOID:1920
Charcot-Marie-Tooth disease contraindication 50548001
Hepatic failure contraindication 59927004
Leukopenia contraindication 84828003 DOID:615
Bacterial infectious disease contraindication 87628006
Peripheral motor neuropathy contraindication 95663000 DOID:683
Neuromyopathy contraindication 255522009 DOID:440
Uric acid renal calculus contraindication 274401005
Pregnancy, function contraindication 289908002
Peripheral nerve disease contraindication 302226006
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Protozoal Infection contraindication
Polyneuropathies contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.02 acidic
pKa2 13.81 acidic
pKa3 7.2 Basic
pKa4 6.58 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Tubulin beta Tumour-associated antigen INHIBITOR SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Multidrug resistance protein 1 Transporter WOMBAT-PK
Canalicular multispecific organic anion transporter 1 Transporter WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter WOMBAT-PK
Multidrug resistance-associated protein 7 Transporter WOMBAT-PK
Tubulin Structural IC50 5.74 CHEMBL

External reference:

IDSource
4019971 VUID
N0000148056 NUI
D02197 KEGG_DRUG
2068-78-2 SECONDARY_CAS_RN
4017542 VANDF
4019971 VANDF
C0042679 UMLSCUI
CHEBI:28445 CHEBI
R1Q PDB_CHEM_ID
CHEMBL90555 ChEMBL_ID
CHEMBL501867 ChEMBL_ID
D014750 MESH_DESCRIPTOR_UI
DB00541 DRUGBANK_ID
6785 IUPHAR_LIGAND_ID
1440 INN_ID
5J49Q6B70F UNII
5978 PUBCHEM_CID
11202 RXNORM
5133 MMSL
5675 MMSL
7308 MMSL
879 MMSL
d00401 MMSL
002656 NDDF
004894 NDDF
23079006 SNOMEDCT_US
387126006 SNOMEDCT_US
387427007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Vincasar PFS HUMAN PRESCRIPTION DRUG LABEL 1 0703-4402 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 20 sections
Vincasar PFS HUMAN PRESCRIPTION DRUG LABEL 1 0703-4412 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 20 sections
VinCRIStine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 61703-309 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 22 sections
VinCRIStine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 61703-309 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 22 sections
VinCRIStine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 61703-309 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 22 sections
VinCRIStine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 61703-309 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 22 sections