ferrous gluconate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4491 299-29-6

Description:

MoleculeDescription

Synonyms:

  • sodium ferric gluconate complex
  • ferrous gluconate
  • iron gluconate
  • ferroglyconicum
  • glucoferron
iron important in this cpd; RN given refers to ferrous cpd
  • Molecular weight: 446.14
  • Formula: C12H22FeO14
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 265.04
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.20 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 18, 1999 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Presbyacusis 148.64 16.26 48 14773 2728 50587575
Pleural fibrosis 139.31 16.26 48 14773 3336 50586967
Pleural thickening 127.26 16.26 42 14779 2557 50587746
Deafness neurosensory 125.95 16.26 48 14773 4453 50585850
Blood magnesium increased 115.26 16.26 40 14781 2840 50587463
Epigastric discomfort 106.98 16.26 46 14775 5824 50584479
Reversible airways obstruction 104.02 16.26 29 14792 991 50589312
Smear cervix abnormal 101.76 16.26 36 14785 2705 50587598
Vital capacity decreased 96.66 16.26 27 14794 929 50589374
Bone cyst 96.26 16.26 32 14789 1992 50588311
Sputum culture positive 86.23 16.26 27 14794 1387 50588916
Bronchial secretion retention 84.43 16.26 27 14794 1486 50588817
Osteosclerosis 79.46 16.26 32 14789 3435 50586868
Osteopenia 68.04 16.26 49 14772 16969 50573334
Cyst 67.64 16.26 43 14778 12144 50578159
Oesophageal spasm 66.09 16.26 25 14796 2271 50588032
Skin fissures 64.71 16.26 37 14784 8631 50581672
Blood pressure decreased 63.42 16.26 80 14741 55829 50534474
Deformity 62.26 16.26 35 14786 7905 50582398
Urticaria 58.67 16.26 122 14699 129439 50460864
Skin lesion 58.19 16.26 54 14767 26673 50563630
Oesophageal pain 57.86 16.26 24 14797 2778 50587525
Blood potassium increased 53.93 16.26 42 14779 16356 50573947
Eosinophil count increased 51.11 16.26 32 14789 8798 50581505
Hyperhidrosis 49.93 16.26 92 14729 89334 50500969
Hypotension 49.10 16.26 166 14655 235303 50355000
Flushing 47.99 16.26 77 14744 66938 50523365
Multiple allergies 47.31 16.26 30 14791 8433 50581870
Dry eye 46.41 16.26 52 14769 32043 50558260
Abdominal pain 45.31 16.26 162 14659 236066 50354237
Osteoarthritis 45.31 16.26 76 14745 68530 50521773
Endodontic procedure 45.09 16.26 20 14801 2726 50587577
Upper-airway cough syndrome 44.56 16.26 29 14792 8521 50581782
Toothache 44.45 16.26 38 14783 16856 50573447
Exostosis 43.06 16.26 32 14789 11621 50578682
Blood pressure fluctuation 41.78 16.26 52 14769 35771 50554532
Infusion related reaction 41.18 16.26 126 14695 169431 50420872
Heart rate decreased 39.44 16.26 51 14770 36446 50553857
Localised infection 38.06 16.26 42 14779 25443 50564860
Tooth disorder 38.05 16.26 41 14780 24187 50566116
Occult blood 37.87 16.26 14 14807 1193 50589110
CFTR gene mutation 37.32 16.26 8 14813 87 50590216
Lymphoedema 35.85 16.26 26 14795 9096 50581207
Medication error 33.73 16.26 47 14774 36057 50554246
Dyspnoea 33.03 16.26 273 14548 547335 50042968
Renal impairment 31.61 16.26 69 14752 75592 50514711
Obstructive airways disorder 30.96 16.26 30 14791 15622 50574681
Alopecia 28.97 16.26 18 14803 245029 50345274
Myocardial infarction 28.30 16.26 73 14748 88954 50501349
Completed suicide 28.00 16.26 3 14818 131886 50458417
Mite allergy 27.99 16.26 9 14812 504 50589799
Chest discomfort 26.41 16.26 73 14748 92649 50497654
Sleep disorder 25.95 16.26 54 14767 57229 50533074
Pulmonary mass 24.83 16.26 29 14792 18676 50571627
Vomiting 24.73 16.26 224 14597 460534 50129769
Burning sensation 24.39 16.26 46 14775 45400 50544903
Blood iron decreased 24.37 16.26 23 14798 11592 50578711
Therapeutic response decreased 24.36 16.26 47 14774 47184 50543119
Abdominal pain upper 23.76 16.26 101 14720 159208 50431095
Skin depigmentation 23.73 16.26 9 14812 823 50589480
Anaphylactic reaction 23.37 16.26 50 14771 54005 50536298
Allergic sinusitis 23.00 16.26 8 14813 571 50589732
Pallor 22.87 16.26 31 14790 23168 50567135
Loss of consciousness 22.06 16.26 74 14747 104279 50486024
Full blood count abnormal 21.18 16.26 30 14791 23358 50566945
Lip pruritus 21.06 16.26 8 14813 735 50589568
Wound 21.01 16.26 3 14818 105791 50484512
Anal incontinence 20.83 16.26 21 14800 11469 50578834
Blood creatinine increased 20.74 16.26 59 14762 76101 50514202
Pancreatitis relapsing 20.71 16.26 8 14813 769 50589534
Nausea 20.35 16.26 304 14517 705094 49885209
Skin discolouration 19.91 16.26 35 14786 32722 50557581
Sputum culture 19.91 16.26 5 14816 113 50590190
Therapeutic reaction time decreased 19.51 16.26 9 14812 1343 50588960
Respiratory tract infection 19.19 16.26 34 14787 31983 50558320
Febrile neutropenia 18.86 16.26 3 14818 97664 50492639
Paraesthesia 18.51 16.26 77 14744 120166 50470137
Bone hypertrophy 18.18 16.26 6 14815 365 50589938
Rheumatoid arthritis 17.96 16.26 111 14710 202439 50387864
Cushingoid 17.59 16.26 15 14806 6630 50583673
Dermatitis psoriasiform 17.52 16.26 9 14812 1697 50588606
Syncope 17.48 16.26 68 14753 102934 50487369
Toxicity to various agents 17.41 16.26 22 14799 212477 50377826
Blood pressure systolic decreased 17.36 16.26 14 14807 5725 50584578
Respiratory alkalosis 16.81 16.26 10 14811 2509 50587794
Fluid retention 16.57 16.26 42 14779 50607 50539696
Sleep apnoea syndrome 16.49 16.26 27 14794 23841 50566462

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 296.89 20.45 79 5772 3401 29565275
Appendicitis 224.82 20.45 79 5772 8700 29559976
Cardiogenic shock 168.13 20.45 80 5771 19110 29549566
Stress 162.48 20.45 81 5770 21409 29547267
Ascites 137.04 20.45 87 5764 36532 29532144
Abdominal distension 121.46 20.45 88 5763 45823 29522853
Vitamin D deficiency 105.19 20.45 40 5811 5489 29563187
Multiple organ dysfunction syndrome 96.81 20.45 88 5763 63028 29505648
Hyponatraemia 87.84 20.45 86 5765 67547 29501129
General physical health deterioration 84.97 20.45 103 5748 102754 29465922
Abdominal pain 77.12 20.45 113 5738 135244 29433432
C-reactive protein decreased 76.64 20.45 23 5828 1528 29567148
Constipation 63.07 20.45 94 5757 114066 29454610
Sepsis 60.35 20.45 104 5747 142578 29426098
Ventricular fibrillation 60.08 20.45 38 5813 15795 29552881
Haematochezia 59.44 20.45 53 5798 36930 29531746
Gastrointestinal disorder 51.89 20.45 44 5807 28662 29540014
Colitis 50.64 20.45 45 5806 31203 29537473
Dental caries 47.79 20.45 21 5830 4159 29564517
Vomiting 47.46 20.45 119 5732 212141 29356535
Peripheral swelling 43.29 20.45 58 5793 63681 29504995
Nausea 37.75 20.45 134 5717 289121 29279555
Drug intolerance 35.90 20.45 46 5805 48333 29520343
Diabetes mellitus inadequate control 31.41 20.45 23 5828 12111 29556565
Blood pressure fluctuation 30.92 20.45 28 5823 19866 29548810
Respiratory symptom 26.05 20.45 9 5842 937 29567739
Dermatitis acneiform 25.48 20.45 15 5836 5476 29563200
Withdrawal hypertension 25.39 20.45 6 5845 157 29568519
Bronchial hyperreactivity 22.58 20.45 9 5842 1397 29567279

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 266.36 16.17 79 18750 3390 64476513
Appendicitis 161.55 16.17 79 18750 13490 64466413
Presbyacusis 135.86 16.17 44 18785 2531 64477372
Pleural fibrosis 116.37 16.17 44 18785 4006 64475897
Pleural thickening 109.96 16.17 38 18791 2672 64477231
Smear cervix abnormal 106.93 16.17 36 18793 2338 64477565
Cardiogenic shock 102.49 16.17 81 18748 32346 64447557
Abdominal pain 101.21 16.17 257 18572 312118 64167785
Deafness neurosensory 97.09 16.17 44 18785 6330 64473573
Blood magnesium increased 96.09 16.17 36 18793 3195 64476708
Bone cyst 93.78 16.17 32 18797 2165 64477738
Reversible airways obstruction 92.09 16.17 27 18802 1111 64478792
Epigastric discomfort 88.15 16.17 42 18787 6769 64473134
Vital capacity decreased 84.84 16.17 25 18804 1047 64478856
Osteosclerosis 82.85 16.17 33 18796 3453 64476450
Stress 82.61 16.17 95 18734 60439 64419464
Ascites 82.43 16.17 96 18733 61905 64417998
Oesophageal spasm 70.98 16.17 27 18802 2498 64477405
Deformity 67.06 16.17 34 18795 6263 64473640
Blood pressure fluctuation 65.11 16.17 78 18751 51793 64428110
Bronchial secretion retention 63.83 16.17 25 18804 2502 64477401
Abdominal distension 63.21 16.17 106 18723 95888 64384015
Osteopenia 62.83 16.17 45 18784 15495 64464408
Oesophageal pain 60.94 16.17 26 18803 3237 64476666
Vomiting 60.91 16.17 319 18510 550798 63929105
Dry eye 60.20 16.17 57 18772 28962 64450941
Sputum culture positive 59.47 16.17 25 18804 3001 64476902
Skin fissures 58.89 16.17 37 18792 10269 64469634
Cyst 58.44 16.17 39 18790 11988 64467915
Vitamin D deficiency 52.25 16.17 36 18793 11656 64468247
Nausea 50.35 16.17 396 18433 785404 63694499
C-reactive protein decreased 50.18 16.17 20 18809 2096 64477807
Infusion related reaction 48.69 16.17 131 18698 164336 64315567
Gastrointestinal disorder 48.64 16.17 91 18738 89618 64390285
Endodontic procedure 48.37 16.17 20 18809 2303 64477600
Completed suicide 47.75 16.17 5 18824 224409 64255494
Multiple allergies 46.67 16.17 26 18803 5788 64474115
Multiple organ dysfunction syndrome 46.66 16.17 96 18733 101317 64378586
Urticaria 46.30 16.17 120 18709 147197 64332706
Exostosis 45.96 16.17 33 18796 11405 64468498
Toothache 45.49 16.17 39 18790 17420 64462483
Peripheral swelling 43.41 16.17 147 18682 209006 64270897
Tooth disorder 42.68 16.17 42 18787 22360 64457543
Flushing 41.66 16.17 79 18750 78569 64401334
Upper-airway cough syndrome 41.56 16.17 28 18801 8742 64471161
Lymphoedema 40.77 16.17 29 18800 9876 64470027
Osteoarthritis 40.42 16.17 69 18760 63267 64416636
Toxicity to various agents 39.66 16.17 29 18800 363484 64116419
Localised infection 38.90 16.17 46 18783 30115 64449788
Rheumatoid arthritis 38.15 16.17 120 18709 164174 64315729
Skin lesion 36.48 16.17 49 18780 36433 64443470
Hyperhidrosis 35.45 16.17 98 18731 124822 64355081
Obstructive airways disorder 34.36 16.17 38 18791 23147 64456756
Joint swelling 34.30 16.17 139 18690 215243 64264660
Eosinophil count increased 33.70 16.17 30 18799 14082 64465821
Ventricular fibrillation 33.46 16.17 38 18791 23822 64456081
CFTR gene mutation 32.69 16.17 7 18822 76 64479827
Blood potassium increased 32.47 16.17 39 18790 25941 64453962
Drug intolerance 31.27 16.17 123 18706 187869 64292034
Blood pressure decreased 28.91 16.17 72 18757 86127 64393776
Neutropenia 26.26 16.17 19 18810 239605 64240298
Febrile neutropenia 26.17 16.17 11 18818 187646 64292257
Hyponatraemia 25.42 16.17 98 18731 148241 64331662
Full blood count abnormal 25.33 16.17 37 18792 29720 64450183
Medication error 24.99 16.17 49 18780 49917 64429986
Heart rate decreased 23.99 16.17 51 18778 55016 64424887
Pyrexia 23.52 16.17 84 18745 558560 63921343
Anaphylactic reaction 22.65 16.17 57 18772 68607 64411296
Blood pressure increased 22.58 16.17 105 18724 172447 64307456
Abdominal pain upper 22.53 16.17 106 18723 174924 64304979
Dyspnoea 22.30 16.17 313 18516 718361 63761542
Sleep disorder 22.30 16.17 52 18777 59657 64420246
Product use in unapproved indication 22.11 16.17 12 18817 176606 64303297
Haematochezia 21.79 16.17 55 18774 66318 64413585
Mite allergy 21.29 16.17 8 18821 715 64479188
Allergic sinusitis 20.55 16.17 7 18822 471 64479432
Pain in extremity 20.50 16.17 155 18674 302930 64176973
Dental caries 20.11 16.17 20 18809 10780 64469123
Blood iron decreased 19.91 16.17 21 18808 12121 64467782
Pulmonary function test abnormal 19.70 16.17 12 18817 3152 64476751
Skin discolouration 19.39 16.17 36 18793 35219 64444684
Therapeutic reaction time decreased 19.32 16.17 10 18819 1922 64477981
Malaise 19.12 16.17 188 18641 396059 64083844
Fibromyalgia 19.04 16.17 36 18793 35695 64444208
Bone hypertrophy 18.96 16.17 6 18823 320 64479583
Withdrawal hypertension 18.94 16.17 6 18823 321 64479582
Interstitial lung disease 18.79 16.17 3 18826 97729 64382174
Colitis 18.62 16.17 48 18781 58626 64421277
Hypotension 18.50 16.17 181 18648 380793 64099110
General physical health deterioration 18.26 16.17 112 18717 204313 64275590
Fluid retention 18.13 16.17 48 18781 59558 64420345
Drug abuse 18.07 16.17 8 18821 132366 64347537
Cystitis 17.98 16.17 39 18790 42636 64437267
Lip pruritus 17.89 16.17 7 18822 698 64479205
Thrombocytopenia 17.34 16.17 24 18805 223777 64256126
Therapeutic product effect decreased 17.20 16.17 73 18756 115278 64364625
Sleep apnoea syndrome 17.08 16.17 31 18798 29801 64450102
Paraesthesia 16.96 16.17 81 18748 134441 64345462
Respiratory tract infection 16.70 16.17 35 18794 37372 64442531
Mobility decreased 16.61 16.17 59 18770 85781 64394122
Pancreatitis relapsing 16.41 16.17 7 18822 871 64479032
Dermatitis acneiform 16.40 16.17 16 18813 8427 64471476

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B03AA03 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron bivalent, oral preparations
ATC B03AD05 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in combination with folic acid
FDA CS M0011718 Iron
MeSH PA D006397 Hematinics
MeSH PA D006401 Hematologic Agents
FDA EPC N0000177913 Parenteral Iron Replacement

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Anemia of prematurity indication 47100003 DOID:11243
Iron deficiency anemia indication 87522002
Peptic ulcer contraindication 13200003 DOID:750
Gastroenteritis contraindication 25374005 DOID:2326
Hemosiderosis contraindication 39011001 DOID:12119
Hemolytic anemia contraindication 61261009 DOID:583
Ulcerative colitis contraindication 64766004 DOID:8577
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Repeated Blood Transfusions contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02394 KEGG_DRUG
4024159 VUID
N0000148626 NUI
34089-81-1 SECONDARY_CAS_RN
4017678 VANDF
4019180 VANDF
4021178 VANDF
4024159 VANDF
CHEBI:31608 CHEBI
CHEMBL3833303 ChEMBL_ID
CHEMBL3991443 ChEMBL_ID
CHEMBL1201494 ChEMBL_ID
C011819 MESH_SUPPLEMENTAL_RECORD_UI
DB14488 DRUGBANK_ID
U1B11I423Z UNII
23616740 PUBCHEM_CID
DB09517 DRUGBANK_ID
24942 RXNORM
189358 MMSL
4724 MMSL
5409 MMSL
7975 MMSL
d03822 MMSL
d04387 MMSL
000834 NDDF
007777 NDDF
116130008 SNOMEDCT_US
26736008 SNOMEDCT_US
387147005 SNOMEDCT_US
786421005 SNOMEDCT_US
C0060277 UMLSCUI
6047-12-7 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ferrlecit HUMAN PRESCRIPTION DRUG LABEL 1 0024-2792 INJECTION 12.50 mg INTRAVENOUS NDA 25 sections
Ferrlecit HUMAN PRESCRIPTION DRUG LABEL 1 0024-2792 INJECTION 12.50 mg INTRAVENOUS NDA 25 sections
Ferrlecit HUMAN PRESCRIPTION DRUG LABEL 1 0024-2794 INJECTION 12.50 mg INTRAVENOUS NDA 26 sections
Ferrlecit HUMAN PRESCRIPTION DRUG LABEL 1 0024-2794 INJECTION 12.50 mg INTRAVENOUS NDA 26 sections
Sodium Ferric Gluconate Complex in Sucrose HUMAN PRESCRIPTION DRUG LABEL 1 0143-9298 INJECTION 12.50 mg INTRAVENOUS ANDA 24 sections
Sodium Ferric Gluconate Complex in Sucrose HUMAN PRESCRIPTION DRUG LABEL 1 0143-9570 INJECTION 12.50 mg INTRAVENOUS ANDA 24 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 13.20 mg ORAL unapproved drug other 15 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 5 mg ORAL unapproved drug other 11 sections
BioFerr 90 HUMAN PRESCRIPTION DRUG LABEL 6 44523-732 TABLET, FILM COATED 13.20 mg ORAL Unapproved drug other 20 sections