ferrous gluconate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4491	299-29-6

Description:

Molecule	Description
Synonyms: sodium ferric gluconate complex ferrous gluconate iron gluconate ferroglyconicum glucoferron	iron important in this cpd; RN given refers to ferrous cpd Molecular weight: 446.14 Formula: C12H22FeO14 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 265.04 ALOGS: ROTB: None

Molecule

Description

Synonyms:

sodium ferric gluconate complex
ferrous gluconate
iron gluconate
ferroglyconicum
glucoferron

iron important in this cpd; RN given refers to ferrous cpd

Molecular weight: 446.14
Formula: C12H22FeO14
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 265.04
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
0.20	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Feb. 18, 1999	FDA	SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Reversible airways obstruction	154.61	16.21	42	15959	1342	56274724
Presbyacusis	153.10	16.21	49	15952	2789	56273277
Vital capacity decreased	148.16	16.21	40	15961	1248	56274818
Pleural fibrosis	143.58	16.21	49	15952	3410	56272656
Sputum culture positive	136.28	16.21	40	15961	1699	56274367
Bronchial secretion retention	133.46	16.21	40	15961	1828	56274238
Pleural thickening	130.58	16.21	43	15958	2680	56273386
Deafness neurosensory	128.93	16.21	49	15952	4649	56271417
Blood magnesium increased	119.35	16.21	41	15960	2910	56273156
Epigastric discomfort	108.80	16.21	47	15954	6201	56269865
Smear cervix abnormal	102.30	16.21	36	15965	2745	56273321
Oesophageal spasm	102.03	16.21	36	15965	2766	56273300
Bone cyst	99.89	16.21	33	15968	2077	56273989
Oesophageal pain	92.91	16.21	35	15966	3240	56272826
Eosinophil count increased	83.75	16.21	45	15956	9592	56266474
Osteosclerosis	82.13	16.21	33	15968	3630	56272436
Upper-airway cough syndrome	76.27	16.21	42	15959	9396	56266670
Multiple allergies	74.76	16.21	43	15958	10453	56265613
Cyst	69.44	16.21	44	15957	12734	56263332
Osteopenia	68.81	16.21	50	15951	18091	56257975
Urticaria	65.68	16.21	134	15867	144542	56131524
Blood pressure decreased	63.41	16.21	81	15920	58969	56217097
Hyperhidrosis	62.81	16.21	103	15898	93985	56182081
Skin fissures	62.32	16.21	37	15964	9536	56266530
Skin lesion	59.12	16.21	55	15946	28080	56247986
Lymphoedema	59.07	16.21	37	15964	10493	56265573
Deformity	57.44	16.21	36	15965	10219	56265847
Obstructive airways disorder	57.43	16.21	44	15957	17238	56258828
Blood potassium increased	55.29	16.21	43	15958	17218	56258848
Abdominal pain	54.08	16.21	179	15822	258626	56017440
Flushing	51.24	16.21	80	15921	70020	56206046
Hypotension	48.58	16.21	169	15832	250339	56025727
Pulmonary mass	46.88	16.21	42	15959	20428	56255638
Dry eye	44.80	16.21	53	15948	35663	56240403
Endodontic procedure	44.38	16.21	20	15981	2916	56273150
Toothache	43.57	16.21	38	15963	17842	56258224
Heart rate decreased	42.67	16.21	55	15946	40372	56235694
Osteoarthritis	42.01	16.21	79	15922	80217	56195849
CFTR gene mutation	41.68	16.21	9	15992	105	56275961
Myocardial infarction	40.90	16.21	85	15916	92785	56183281
Full blood count abnormal	39.53	16.21	43	15958	26419	56249647
Exostosis	38.93	16.21	33	15968	14910	56261156
Dyspnoea	38.70	16.21	294	15707	592283	55683783
Occult blood	38.16	16.21	14	15987	1203	56274863
Blood pressure fluctuation	38.11	16.21	52	15949	40308	56235758
Alopecia	37.95	16.21	18	15983	293440	55982626
Tooth disorder	37.26	16.21	41	15960	25512	56250554
Localised infection	36.58	16.21	42	15959	27370	56248696
Respiratory tract infection	34.86	16.21	47	15954	36024	56240042
Medication error	31.88	16.21	49	15952	42286	56233780
Sleep apnoea syndrome	31.57	16.21	38	15963	26023	56250043
Infusion related reaction	31.39	16.21	130	15871	208801	56067265
Renal impairment	31.10	16.21	70	15931	80643	56195423
Abdominal pain upper	30.03	16.21	115	15886	178198	56097868
Vomiting	29.06	16.21	241	15760	497987	55778079
Wound	28.77	16.21	3	15998	138801	56137265
Discoloured vomit	28.40	16.21	10	15991	763	56275303
Fluid retention	28.02	16.21	53	15948	54025	56222041
Sputum culture	27.84	16.21	7	15994	164	56275902
Mite allergy	27.64	16.21	9	15992	541	56275525
Completed suicide	27.46	16.21	3	15998	133830	56142236
Tinnitus	27.30	16.21	38	15963	30004	56246062
Chest discomfort	26.80	16.21	75	15926	98782	56177284
Allergic sinusitis	25.72	16.21	9	15992	674	56275392
Lip pruritus	24.19	16.21	9	15992	804	56275262
Cystitis	24.10	16.21	47	15954	48991	56227075
Pancreatitis relapsing	23.77	16.21	9	15992	844	56275222
Anaphylactic reaction	23.66	16.21	52	15949	58943	56217123
Blood iron decreased	23.33	16.21	23	15978	12604	56263462
Sleep disorder	23.12	16.21	56	15945	67607	56208459
Burning sensation	23.12	16.21	46	15955	48650	56227416
Skin depigmentation	23.11	16.21	9	15992	911	56275155
Loss of consciousness	23.10	16.21	76	15925	109273	56166793
Blood creatinine increased	22.88	16.21	62	15939	80129	56195937
Pallor	22.62	16.21	31	15970	24118	56251948
Skin discolouration	22.07	16.21	37	15964	34319	56241747
Therapeutic response decreased	21.72	16.21	47	15954	52711	56223355
Bone hypertrophy	21.67	16.21	7	15994	410	56275656
Malaise	21.43	16.21	178	15823	367682	55908384
Agitation	20.91	16.21	48	15953	55988	56220078
Therapeutic reaction time decreased	20.43	16.21	10	15991	1754	56274312
Anal incontinence	20.16	16.21	21	15980	12277	56263789
Nausea	19.60	16.21	315	15686	763863	55512203
Febrile neutropenia	17.96	16.21	4	15997	105541	56170525
Internal haemorrhage	17.76	16.21	13	15988	4751	56271315
Syncope	17.56	16.21	69	15932	108130	56167936
Depression	17.55	16.21	99	15902	180018	56096048
Toxicity to various agents	17.41	16.21	23	15978	224541	56051525
Paraesthesia	17.12	16.21	78	15923	130436	56145630
Dermatitis psoriasiform	17.07	16.21	9	15992	1845	56274221
Respiratory alkalosis	16.97	16.21	10	15991	2541	56273525
Cushingoid	16.60	16.21	15	15986	7369	56268697
Blood pressure systolic decreased	16.50	16.21	14	15987	6329	56269737

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	382.79	20.47	109	6637	5622	31684976
Appendicitis	308.41	20.47	109	6637	11356	31679242
Cardiogenic shock	240.81	20.47	110	6636	22298	31668300
Stress	235.68	20.47	112	6634	24829	31665769
Ascites	196.29	20.47	117	6629	40896	31649702
Abdominal distension	175.94	20.47	118	6628	50566	31640032
Multiple organ dysfunction syndrome	142.48	20.47	117	6629	68086	31622512
Ventricular fibrillation	134.49	20.47	70	6676	18778	31671820
Hyponatraemia	132.40	20.47	116	6630	73683	31616915
General physical health deterioration	120.71	20.47	134	6612	113301	31577297
Abdominal pain	108.89	20.47	144	6602	145808	31544790
Vitamin D deficiency	99.61	20.47	40	6706	5892	31684706
Constipation	96.54	20.47	125	6621	123866	31566732
Sepsis	91.06	20.47	135	6611	151794	31538804
Blood phosphorus increased	81.44	20.47	32	6714	4450	31686148
C-reactive protein decreased	71.42	20.47	23	6723	1792	31688806
Vomiting	68.10	20.47	148	6598	223825	31466773
Nausea	54.57	20.47	166	6580	307781	31382817
Haematochezia	52.07	20.47	53	6693	40411	31650187
Gastrointestinal disorder	48.53	20.47	45	6701	30615	31659983
Dental caries	45.74	20.47	21	6725	4280	31686318
Colitis	44.71	20.47	45	6701	33842	31656756
Peripheral swelling	40.04	20.47	60	6686	67805	31622793
Blood pressure fluctuation	35.25	20.47	33	6713	22703	31667895
Drug intolerance	35.06	20.47	49	6697	51984	31638614
Diabetes mellitus inadequate control	28.92	20.47	23	6723	12718	31677880
Dermatitis acneiform	23.79	20.47	15	6731	5752	31684846
Withdrawal hypertension	23.71	20.47	6	6740	195	31690403
Dry mouth	22.69	20.47	27	6719	24431	31666167
Respiratory symptom	22.58	20.47	9	6737	1297	31689301
Bronchial hyperreactivity	21.70	20.47	9	6737	1436	31689162
Off label use	20.52	20.47	135	6611	347139	31343459

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	344.42	16.06	108	20708	5572	70902056
Appendicitis	230.96	16.06	108	20708	16625	70891003
Cardiogenic shock	157.68	16.06	110	20706	36197	70871431
Presbyacusis	138.66	16.06	45	20771	2592	70905036
Reversible airways obstruction	138.13	16.06	40	20776	1567	70906061
Vital capacity decreased	134.23	16.06	38	20778	1371	70906257
Abdominal pain	134.18	16.06	304	20512	341823	70565805
Ascites	125.27	16.06	125	20691	67422	70840206
Stress	124.62	16.06	125	20691	67841	70839787
Pleural fibrosis	118.81	16.06	45	20771	4094	70903534
Pleural thickening	111.96	16.06	39	20777	2793	70904835
Oesophageal spasm	108.13	16.06	39	20777	3092	70904536
Smear cervix abnormal	106.42	16.06	36	20780	2360	70905268
Bronchial secretion retention	105.86	16.06	38	20778	2972	70904656
Sputum culture positive	101.85	16.06	38	20778	3316	70904312
Blood magnesium increased	98.45	16.06	37	20779	3294	70904334
Deafness neurosensory	98.32	16.06	45	20771	6587	70901041
Abdominal distension	97.33	16.06	136	20680	104533	70803095
Oesophageal pain	97.21	16.06	38	20778	3764	70903864
Bone cyst	88.87	16.06	33	20783	2841	70904787
Epigastric discomfort	88.53	16.06	43	20773	7190	70900438
Ventricular fibrillation	88.09	16.06	69	20747	27042	70880586
Osteosclerosis	84.16	16.06	34	20782	3671	70903957
Vomiting	80.22	16.06	365	20451	592746	70314882
Multiple organ dysfunction syndrome	76.61	16.06	124	20692	108391	70799237
Multiple allergies	74.09	16.06	39	20777	7721	70899907
Upper-airway cough syndrome	71.12	16.06	41	20775	9690	70897938
Lymphoedema	65.89	16.06	41	20775	11128	70896500
Blood pressure fluctuation	64.49	16.06	83	20733	58929	70848699
Osteopenia	61.95	16.06	46	20770	16651	70890977
Blood phosphorus increased	61.74	16.06	33	20783	6737	70900891
Deformity	60.75	16.06	35	20781	8262	70899366
Eosinophil count increased	58.87	16.06	43	20773	15179	70892449
Cyst	58.63	16.06	40	20776	12679	70894949
Nausea	58.42	16.06	438	20378	851650	70055978
Dry eye	56.62	16.06	58	20758	32224	70875404
Skin fissures	55.68	16.06	37	20779	11233	70896395
Obstructive airways disorder	53.37	16.06	51	20765	26062	70881566
Urticaria	52.02	16.06	134	20682	162915	70744713
Vitamin D deficiency	49.94	16.06	36	20780	12451	70895177
Completed suicide	48.80	16.06	5	20811	227130	70680498
C-reactive protein decreased	47.45	16.06	20	20796	2404	70905224
Endodontic procedure	46.57	16.06	20	20796	2517	70905111
Hyponatraemia	46.43	16.06	127	20689	159960	70747668
Full blood count abnormal	45.68	16.06	53	20763	33825	70873803
Hyperhidrosis	44.94	16.06	111	20705	131475	70776153
Toothache	43.48	16.06	39	20777	18391	70889237
Gastrointestinal disorder	41.49	16.06	94	20722	105333	70802295
Toxicity to various agents	41.45	16.06	31	20785	382141	70525487
Flushing	41.33	16.06	81	20735	82091	70825537
Exostosis	41.25	16.06	34	20782	14311	70893317
Tooth disorder	40.16	16.06	42	20774	23896	70883732
Infusion related reaction	38.95	16.06	137	20679	197397	70710231
CFTR gene mutation	36.74	16.06	8	20808	94	70907534
Skin lesion	35.74	16.06	50	20766	38410	70869218
Localised infection	35.22	16.06	46	20770	33112	70874516
Osteoarthritis	34.78	16.06	71	20745	74076	70833552
Peripheral swelling	34.37	16.06	149	20667	236414	70671214
Sepsis	32.49	16.06	150	20666	244395	70663233
Blood potassium increased	32.32	16.06	40	20776	27286	70880342
Pulmonary mass	32.24	16.06	39	20777	25994	70881634
Sleep apnoea syndrome	31.10	16.06	43	20773	32670	70874958
Cystitis	30.88	16.06	52	20764	46889	70860739
Fluid retention	30.09	16.06	61	20755	63324	70844304
General physical health deterioration	30.05	16.06	143	20673	235888	70671740
Respiratory tract infection	29.28	16.06	48	20768	42350	70865278
Blood pressure decreased	28.93	16.06	75	20741	91440	70816188
Heart rate decreased	28.63	16.06	59	20757	61956	70845672
Abdominal pain upper	28.15	16.06	122	20694	193480	70714148
Product use in unapproved indication	27.87	16.06	13	20803	207465	70700163
Pyrexia	27.57	16.06	89	20727	606863	70300765
Febrile neutropenia	27.14	16.06	13	20803	204305	70703323
Fibromyalgia	25.05	16.06	48	20768	47826	70859802
Tinnitus	25.04	16.06	41	20775	36135	70871493
Constipation	24.58	16.06	142	20674	252296	70655332
Neutropenia	24.04	16.06	24	20792	257132	70650496
Allergic sinusitis	23.81	16.06	8	20808	513	70907115
Joint swelling	23.73	16.06	141	20675	253070	70654558
Discoloured vomit	23.04	16.06	10	20806	1291	70906337
Dyspnoea	22.75	16.06	334	20482	769726	70137902
Medication error	22.66	16.06	51	20765	56861	70850767
Malaise	22.24	16.06	209	20607	432723	70474905
Bone hypertrophy	22.18	16.06	7	20809	368	70907260
Drug intolerance	22.00	16.06	127	20689	225560	70682068
Blood iron decreased	21.76	16.06	23	20793	13238	70894390
Drug abuse	21.75	16.06	8	20808	147248	70760380
Anaphylactic reaction	21.23	16.06	59	20757	74915	70832713
Interstitial lung disease	20.76	16.06	3	20813	104682	70802946
Lip pruritus	20.66	16.06	8	20808	772	70906856
Myocardial infarction	20.40	16.06	102	20714	171543	70736085
Alopecia	20.36	16.06	17	20799	198473	70709155
Blood pressure increased	20.31	16.06	109	20707	188408	70719220
Skin discolouration	20.24	16.06	38	20778	37287	70870341
Sputum culture	19.94	16.06	5	20811	112	70907516
Mite allergy	19.88	16.06	8	20808	855	70906773
Dental caries	19.45	16.06	20	20796	11151	70896477
Pancreatitis relapsing	19.36	16.06	8	20808	915	70906713
Wound	19.19	16.06	3	20813	98729	70808899
Therapeutic reaction time decreased	19.13	16.06	11	20805	2586	70905042
Intentional overdose	19.11	16.06	3	20813	98432	70809196
Pulmonary function test abnormal	18.77	16.06	12	20804	3413	70904215
Migraine	18.66	16.06	55	20761	72183	70835445
Thrombocytopenia	18.41	16.06	26	20790	239084	70668544
Haematochezia	18.27	16.06	55	20761	73026	70834602
Withdrawal hypertension	18.13	16.06	6	20810	367	70907261
Sleep disorder	17.86	16.06	53	20763	69819	70837809
Iron deficiency anaemia	17.13	16.06	27	20789	23045	70884583
Colitis	16.88	16.06	49	20767	63765	70843863
Hypotension	16.82	16.06	187	20629	404194	70503434
Nephrogenic systemic fibrosis	16.68	16.06	14	20802	6038	70901590
Platelet count decreased	16.23	16.06	17	20799	178205	70729423
Pain in extremity	16.14	16.06	157	20659	327925	70579703

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B03AA03	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS IRON PREPARATIONS Iron bivalent, oral preparations
ATC	B03AD05	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS IRON PREPARATIONS Iron in combination with folic acid
FDA CS	M0011718	Iron
MeSH PA	D006397	Hematinics
MeSH PA	D006401	Hematologic Agents
FDA EPC	N0000177913	Parenteral Iron Replacement

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Anemia of prematurity	indication	47100003	DOID:11243
Iron deficiency anemia	indication	87522002
Peptic ulcer	contraindication	13200003	DOID:750
Gastroenteritis	contraindication	25374005	DOID:2326
Hemosiderosis	contraindication	39011001	DOID:12119
Hemolytic anemia	contraindication	61261009	DOID:583
Ulcerative colitis	contraindication	64766004	DOID:8577
Diverticular disease	contraindication	397881000
Hemochromatosis	contraindication	399187006	DOID:2352
Repeated Blood Transfusions	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D02394	KEGG_DRUG
4024159	VUID
N0000148626	NUI
6047-12-7	SECONDARY_CAS_RN
34089-81-1	SECONDARY_CAS_RN
4017678	VANDF
4019180	VANDF
4021178	VANDF
4024159	VANDF
CHEBI:31608	CHEBI
CHEMBL3833303	ChEMBL_ID
CHEMBL3991443	ChEMBL_ID
CHEMBL1201494	ChEMBL_ID
C011819	MESH_SUPPLEMENTAL_RECORD_UI
DB14488	DRUGBANK_ID
U1B11I423Z	UNII
DB09517	DRUGBANK_ID
24942	RXNORM
189358	MMSL
4724	MMSL
5409	MMSL
7975	MMSL
d03822	MMSL
d04387	MMSL
000834	NDDF
007777	NDDF
116130008	SNOMEDCT_US
26736008	SNOMEDCT_US
387147005	SNOMEDCT_US
786421005	SNOMEDCT_US
C0060277	UMLSCUI
23616740	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ferrlecit	HUMAN PRESCRIPTION DRUG LABEL	1	0024-2792	INJECTION	12.50 mg	INTRAVENOUS	NDA	25 sections
Ferrlecit	HUMAN PRESCRIPTION DRUG LABEL	1	0024-2792	INJECTION	12.50 mg	INTRAVENOUS	NDA	25 sections
Ferrlecit	HUMAN PRESCRIPTION DRUG LABEL	1	0024-2794	INJECTION	12.50 mg	INTRAVENOUS	NDA	26 sections
Ferrlecit	HUMAN PRESCRIPTION DRUG LABEL	1	0024-2794	INJECTION	12.50 mg	INTRAVENOUS	NDA	26 sections
Sodium Ferric Gluconate Complex in Sucrose	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9298	INJECTION	12.50 mg	INTRAVENOUS	ANDA	24 sections
Sodium Ferric Gluconate Complex in Sucrose	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9570	INJECTION	12.50 mg	INTRAVENOUS	ANDA	24 sections
Sodium Ferric Gluconate Complex in Sucrose	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9570	INJECTION	12.50 mg	INTRAVENOUS	ANDA	24 sections
CitraNatal Bloom	HUMAN PRESCRIPTION DRUG LABEL	6	0178-0813	TABLET, FILM COATED	13.20 mg	ORAL	unapproved drug other	15 sections
CitraNatal Bloom	HUMAN PRESCRIPTION DRUG LABEL	6	0178-0813	TABLET, FILM COATED	13.20 mg	ORAL	unapproved drug other	15 sections
CitraNatal 90 DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0178-0821	TABLET	5 mg	ORAL	unapproved drug other	11 sections
CitraNatal 90 DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0178-0821	TABLET	5 mg	ORAL	unapproved drug other	11 sections
BioFerr 90	HUMAN PRESCRIPTION DRUG LABEL	6	44523-732	TABLET, FILM COATED	13.20 mg	ORAL	Unapproved drug other	20 sections