potassium iodide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
radiopharmaceuticals, iodine-contained	4296	7681-11-0

Description:

Molecule	Description
Synonyms: potassium iodide kalium iodidum potassium monoiodide	An inorganic compound that is used as a source of iodine in thyrotoxic crisis and in the preparation of thyrotoxic patients for thyroidectomy. (From Dorland, 27th ed) Molecular weight: 166.00 Formula: IK CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

potassium iodide
kalium iodidum
potassium monoiodide

An inorganic compound that is used as a source of iodine in thyrotoxic crisis and in the preparation of thyrotoxic patients for thyroidectomy. (From Dorland, 27th ed)

Molecular weight: 166.00
Formula: IK
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
1.20	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Nov. 9, 1979	FDA	MEDPOINTE PHARM HLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperthyroidism	38.71	20.47	16	2336	14657	63472013
Hypokalaemia	23.88	20.47	24	2328	103780	63382890
Obstructive pancreatitis	23.85	20.47	5	2347	418	63486252
General physical health deterioration	23.67	20.47	33	2319	201369	63285301
Anuria	21.17	20.47	10	2342	12541	63474129

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic epidermal necrolysis	45.76	27.29	18	858	21628	34934427
Regurgitation	39.27	27.29	9	867	1690	34954365
Oropharyngeal discomfort	33.62	27.29	9	867	3187	34952868
Vitamin B12 deficiency	31.55	27.29	9	867	4022	34952033
Eructation	30.13	27.29	9	867	4722	34951333

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperthyroidism	39.22	20.61	17	2314	22192	79719865
General physical health deterioration	35.70	20.61	42	2289	275196	79466861
Regurgitation	33.44	20.61	9	2322	2778	79739279
Toxic epidermal necrolysis	30.62	20.61	18	2313	44563	79697494
Vitamin B12 deficiency	28.79	20.61	10	2321	7231	79734826
Hypokalaemia	25.65	20.61	26	2305	144014	79598043
Oropharyngeal discomfort	25.07	20.61	9	2322	7157	79734900
Eructation	24.79	20.61	10	2321	10899	79731158
Thyrotoxic crisis	24.49	20.61	6	2325	1278	79740779

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R05CA02	RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS Expectorants
ATC	S01XA04	SENSORY ORGANS OPHTHALMOLOGICALS OTHER OPHTHALMOLOGICALS Other ophthalmologicals
ATC	V03AB21	VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Antidotes
CHEBI has role	CHEBI:48578	free radical scavengers
CHEBI has role	CHEBI:77035	expectorants

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Cough	indication	49727002
Allergic rhinitis	indication	61582004
Nasal discharge	indication	64531003
Nasal congestion	indication	68235000
Common cold	indication	82272006	DOID:10459
Thyroid Gland Radiation Protection	indication
Neonatal thyrotoxicosis	off-label use	13795004	DOID:12573
Lymphocutaneous sporotrichosis	off-label use	87603003
Thyroid Surgery	off-label use
Goiter	contraindication	3716002	DOID:12176
Tachyarrhythmia	contraindication	6285003
Suicidal thoughts	contraindication	6471006
Dependent drug abuse	contraindication	6525002
Alcoholism	contraindication	7200002
Hyperammonemia	contraindication	9360008
Peptic ulcer	contraindication	13200003	DOID:750
Chronic obstructive lung disease	contraindication	13645005	DOID:3083
Hepatic encephalopathy	contraindication	13920009	DOID:13413
Hyperkalemia	contraindication	14140009
Chronic disease of respiratory system	contraindication	17097001
Mood swings	contraindication	18963009
Pulmonary edema	contraindication	19242006	DOID:11396
Hashimoto thyroiditis	contraindication	21983002
Myocardial infarction	contraindication	22298006	DOID:5844
Inflammatory bowel disease	contraindication	24526004	DOID:0050589
Ventricular tachycardia	contraindication	25569003
Acute tuberculosis	contraindication	25629007
Shock	contraindication	27942005
Bronchitis	contraindication	32398004	DOID:6132
Hyperthyroidism	contraindication	34486009	DOID:7998
Depressive disorder	contraindication	35489007
Acute hepatitis	contraindication	37871000
Hypertensive disorder	contraindication	38341003	DOID:10763
Disorder of gallbladder	contraindication	39621005	DOID:0060262
Hypothyroidism	contraindication	40930008	DOID:1459
Third trimester pregnancy	contraindication	41587001
Conduction disorder of the heart	contraindication	44808001
Low blood pressure	contraindication	45007003
Chronic heart failure	contraindication	48447003
Bradycardia	contraindication	48867003
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Acidosis	contraindication	51387008
Multiple organ failure	contraindication	57653000
Hepatic failure	contraindication	59927004
Poisoning by phenobarbital	contraindication	64921004
Arterial thrombosis	contraindication	65198009
Drug AND/OR toxin-induced diarrhea	contraindication	65979008
Substance abuse	contraindication	66214007
Benign intracranial hypertension	contraindication	68267002	DOID:11459
Psychotic disorder	contraindication	69322001
Arteriosclerotic vascular disease	contraindication	72092001
Hepatic coma	contraindication	72836002	DOID:12550
Diabetes mellitus	contraindication	73211009	DOID:9351
Sleep apnea	contraindication	73430006	DOID:0050847
Urethral stricture	contraindication	76618002
Decreased respiratory function	contraindication	80954004
Injury of head	contraindication	82271004
Chronic idiopathic constipation	contraindication	82934008
Cor pulmonale	contraindication	83291003	DOID:8515
Epilepsy	contraindication	84757009	DOID:1826
Kidney disease	contraindication	90708001	DOID:557
Dermatitis herpetiformis	contraindication	111196000	DOID:8505
Acute abdominal pain	contraindication	116290004
Procedure on urinary system	contraindication	118677009
Gastrointestinal obstruction	contraindication	126765001
Seizure disorder	contraindication	128613002
Cystic fibrosis	contraindication	190905008	DOID:1485
Angina pectoris	contraindication	194828000
Partial atrioventricular block	contraindication	195039008
Acute pancreatitis	contraindication	197456007	DOID:2913
Disease of liver	contraindication	235856003	DOID:409
Bladder outflow obstruction	contraindication	236645006
Sepsis syndrome	contraindication	238150007
Hypocomplementemic urticarial vasculitis	contraindication	239945009
Benign prostatic hyperplasia	contraindication	266569009
Dyspnea	contraindication	267036007
Retention of urine	contraindication	267064002
Anemia	contraindication	271737000	DOID:2355
Continuous fever	contraindication	271751000
Pregnancy, function	contraindication	289908002
Lesion of brain	contraindication	301766008
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Neutropenic disorder	contraindication	303011007	DOID:1227
Primary adrenocortical insufficiency	contraindication	373662000
Smoking cessation assistance	contraindication	384742004
Operation on gastrointestinal tract	contraindication	386621005
Hypoxia	contraindication	389086002
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Pseudomembranous enterocolitis	contraindication	397683000
Breastfeeding (mother)	contraindication	413712001
Chronic myocardial ischemia	contraindication	413844008	DOID:3393
Disorder of coronary artery	contraindication	414024009
Myocardial ischemia	contraindication	414795007	DOID:3393
Central nervous system depression	contraindication	418072004
Porphyria	contraindication	418470004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant	contraindication	422681000
Dysfunction of sphincter of Oddi	contraindication	430887001
Hypertensive urgency	contraindication	443482000
Smokes tobacco daily	contraindication	449868002
Acute exacerbation of asthma	contraindication	708038006
Severe Hypoxemia	contraindication
Theophylline Toxicity	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN		Ki	4.10		CHEMBL

External reference:

ID	Source
4017676	VUID
N0000146052	NUI
D01016	KEGG_DRUG
4017645	VANDF
4017676	VANDF
C0032831	UMLSCUI
CHEBI:8346	CHEBI
CHEMBL1141	ChEMBL_ID
D011193	MESH_DESCRIPTOR_UI
DB06715	DRUGBANK_ID
1C4QK22F9J	UNII
4875	PUBCHEM_CID
8597	RXNORM
1847	MMSL
5333	MMSL
d00800	MMSL
000734	NDDF
000846	NDDF
003151	NDDF
007600	NDDF
400389005	SNOMEDCT_US
89351005	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
POTASSIUM IODIDE	HUMAN OTC DRUG LABEL	1	0178-0314	SOLUTION	65 mg	ORAL	ANDA	17 sections
POTASSIUM IODIDE	HUMAN OTC DRUG LABEL	1	0178-0314	SOLUTION	65 mg	ORAL	ANDA	17 sections
CitraNatal 90 DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0178-0821	TABLET	150 ug	ORAL	unapproved drug other	11 sections
CitraNatal 90 DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0178-0821	TABLET	150 ug	ORAL	unapproved drug other	11 sections
CitraNatal Rx	HUMAN PRESCRIPTION DRUG LABEL	13	0178-0858	TABLET	150 mg	ORAL	Unapproved drug other	12 sections
CitraNatal Rx	HUMAN PRESCRIPTION DRUG LABEL	14	0178-0859	TABLET	150 mg	ORAL	Unapproved drug other	9 sections
CitraNatal DHA	HUMAN OTC DRUG LABEL	14	0178-0898	TABLET	150 mg	ORAL	Unapproved drug other	11 sections
ThyroShield	HUMAN OTC DRUG LABEL	1	0256-0210	SOLUTION	65 mg	ORAL	ANDA	24 sections
Humco Strong Iodine	HUMAN PRESCRIPTION DRUG LABEL	2	0395-2775	LIQUID	100 mg	ORAL	unapproved drug other	12 sections
Humco Strong Iodine	HUMAN PRESCRIPTION DRUG LABEL	2	0395-2775	LIQUID	100 mg	ORAL	unapproved drug other	12 sections
Vitafol Ultra	HUMAN PRESCRIPTION DRUG LABEL	17	0642-0093	CAPSULE, LIQUID FILLED	150 ug	ORAL	UNAPPROVED DRUG OTHER	13 sections
Vitafol Ultra	HUMAN PRESCRIPTION DRUG LABEL	17	0642-0093	CAPSULE, LIQUID FILLED	150 ug	ORAL	UNAPPROVED DRUG OTHER	13 sections
Vitafol Fe Plus	HUMAN PRESCRIPTION DRUG LABEL	17	0642-7473	CAPSULE, LIQUID FILLED	150 ug	ORAL	UNAPPROVED DRUG OTHER	14 sections
Vitafol Fe Plus	HUMAN PRESCRIPTION DRUG LABEL	17	0642-7473	CAPSULE, LIQUID FILLED	150 ug	ORAL	UNAPPROVED DRUG OTHER	14 sections
TriStart DHA	HUMAN PRESCRIPTION DRUG LABEL	15	15370-250	CAPSULE, LIQUID FILLED	200 ug	ORAL	UNAPPROVED DRUG OTHER	12 sections
Potassium Iodide	HUMAN PRESCRIPTION DRUG LABEL	1	16477-601	SOLUTION	1 g	ORAL	unapproved drug other	18 sections
IODINE	HUMAN OTC DRUG LABEL	2	16638-166	SOLUTION	0.20 g	TOPICAL	OTC monograph not final	9 sections
SSKI	HUMAN PRESCRIPTION DRUG LABEL	1	17856-0114	SOLUTION	1 g	ORAL	UNAPPROVED DRUG OTHER	18 sections
SSKI	HUMAN PRESCRIPTION DRUG LABEL	1	17856-0114	SOLUTION	1 g	ORAL	UNAPPROVED DRUG OTHER	18 sections
PNV-Select	HUMAN PRESCRIPTION DRUG LABEL	18	42192-320	TABLET, FILM COATED	150 ug	ORAL	unapproved drug other	10 sections
PNV-Omega	HUMAN PRESCRIPTION DRUG LABEL	13	42192-332	CAPSULE, GELATIN COATED	150 ug	ORAL	unapproved drug other	12 sections
Strong Iodine Solution	HUMAN PRESCRIPTION DRUG LABEL	2	48433-230	SOLUTION/ DROPS	1400 mg	ORAL	unapproved drug other	11 sections
ThyroSafe	HUMAN OTC DRUG LABEL	1	50633-910	TABLET	65 mg	ORAL	ANDA	10 sections
NESTABSPrenatal Multi-vitamin/Mineral Supplement	HUMAN PRESCRIPTION DRUG LABEL	15	50967-219	TABLET, FILM COATED	100 ug	ORAL	unapproved drug other	8 sections
NESTABSPrenatal Multi-vitamin/Mineral Supplement	HUMAN PRESCRIPTION DRUG LABEL	15	50967-219	TABLET, FILM COATED	100 ug	ORAL	unapproved drug other	8 sections
IOSAT	HUMAN OTC DRUG LABEL	1	51803-001	TABLET	130 mg	ORAL	NDA	16 sections
IOSAT	HUMAN OTC DRUG LABEL	1	51803-001	TABLET	130 mg	ORAL	NDA	16 sections
IOSAT	HUMAN OTC DRUG LABEL	1	51803-001	TABLET	130 mg	ORAL	NDA	16 sections
IOSAT	HUMAN OTC DRUG LABEL	1	51803-002	TABLET	65 mg	ORAL	NDA	16 sections
IOSAT	HUMAN OTC DRUG LABEL	1	51803-002	TABLET	65 mg	ORAL	NDA	16 sections