potassium iodide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4296 7681-11-0

Description:

MoleculeDescription

Synonyms:

  • potassium iodide
  • kalium iodidum
  • potassium monoiodide
An inorganic compound that is used as a source of iodine in thyrotoxic crisis and in the preparation of thyrotoxic patients for thyroidectomy. (From Dorland, 27th ed)
  • Molecular weight: 166.00
  • Formula: IK
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
1.20 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Nov. 9, 1979 FDA MEDPOINTE PHARM HLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthyroidism 45.93 22.44 16 1408 12159 50591541

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic epidermal necrolysis 31.94 27.34 13 683 18140 29555691
Regurgitation 31.06 27.34 7 689 1300 29572531

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthyroidism 40.01 21.18 16 1759 18163 64478794
Regurgitation 26.62 21.18 7 1768 2102 64494855
Vitamin B12 deficiency 23.95 21.18 8 1767 5464 64491493

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R05CA02 RESPIRATORY SYSTEM
COUGH AND COLD PREPARATIONS
EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS
Expectorants
ATC S01XA04 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
ATC V03AB21 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Antidotes
CHEBI has role CHEBI:48578 free radical scavengers
CHEBI has role CHEBI:77035 expectorants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Cough indication 49727002
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Common cold indication 82272006 DOID:10459
Thyroid Gland Radiation Protection indication
Neonatal thyrotoxicosis off-label use 13795004 DOID:12573
Lymphocutaneous sporotrichosis off-label use 87603003
Thyroid Surgery off-label use
Goiter contraindication 3716002 DOID:12176
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Alcoholism contraindication 7200002
Hyperammonemia contraindication 9360008
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Hepatic encephalopathy contraindication 13920009 DOID:13413
Hyperkalemia contraindication 14140009
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Pulmonary edema contraindication 19242006 DOID:11396
Hashimoto thyroiditis contraindication 21983002
Myocardial infarction contraindication 22298006 DOID:5844
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Acute tuberculosis contraindication 25629007
Shock contraindication 27942005
Bronchitis contraindication 32398004 DOID:6132
Hyperthyroidism contraindication 34486009 DOID:7998
Depressive disorder contraindication 35489007
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Hypothyroidism contraindication 40930008 DOID:1459
Third trimester pregnancy contraindication 41587001
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acidosis contraindication 51387008
Multiple organ failure contraindication 57653000
Hepatic failure contraindication 59927004
Poisoning by phenobarbital contraindication 64921004
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Psychotic disorder contraindication 69322001
Arteriosclerotic vascular disease contraindication 72092001
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050847
Urethral stricture contraindication 76618002
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Cor pulmonale contraindication 83291003 DOID:8515
Epilepsy contraindication 84757009 DOID:1826
Kidney disease contraindication 90708001 DOID:557
Dermatitis herpetiformis contraindication 111196000 DOID:8505
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
Gastrointestinal obstruction contraindication 126765001
Seizure disorder contraindication 128613002
Cystic fibrosis contraindication 190905008 DOID:1485
Angina pectoris contraindication 194828000
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Sepsis syndrome contraindication 238150007
Hypocomplementemic urticarial vasculitis contraindication 239945009
Benign prostatic hyperplasia contraindication 266569009
Dyspnea contraindication 267036007
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Continuous fever contraindication 271751000
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Primary adrenocortical insufficiency contraindication 373662000
Smoking cessation assistance contraindication 384742004
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Pseudomembranous enterocolitis contraindication 397683000
Breastfeeding (mother) contraindication 413712001
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Dysfunction of sphincter of Oddi contraindication 430887001
Hypertensive urgency contraindication 443482000
Smokes tobacco daily contraindication 449868002
Acute exacerbation of asthma contraindication 708038006
Severe Hypoxemia contraindication
Theophylline Toxicity contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 4 Enzyme Ki 4.10 CHEMBL

External reference:

IDSource
4017676 VUID
N0000146052 NUI
D01016 KEGG_DRUG
4017645 VANDF
4017676 VANDF
C0032831 UMLSCUI
CHEBI:8346 CHEBI
CHEMBL1141 ChEMBL_ID
D011193 MESH_DESCRIPTOR_UI
DB06715 DRUGBANK_ID
1C4QK22F9J UNII
4875 PUBCHEM_CID
8597 RXNORM
1847 MMSL
5333 MMSL
d00800 MMSL
000734 NDDF
000846 NDDF
003151 NDDF
007600 NDDF
400389005 SNOMEDCT_US
89351005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
POTASSIUM IODIDE HUMAN OTC DRUG LABEL 1 0178-0314 SOLUTION 65 mg ORAL ANDA 17 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 150 ug ORAL unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 150 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 150 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 150 mg ORAL Unapproved drug other 11 sections
ThyroShield HUMAN OTC DRUG LABEL 1 0256-0210 SOLUTION 65 mg ORAL ANDA 12 sections
Humco Strong Iodine HUMAN PRESCRIPTION DRUG LABEL 2 0395-2775 LIQUID 100 mg ORAL unapproved drug other 12 sections
Humco Strong Iodine HUMAN PRESCRIPTION DRUG LABEL 2 0395-2775 LIQUID 100 mg ORAL unapproved drug other 12 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 150 ug ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 150 ug ORAL UNAPPROVED DRUG OTHER 14 sections
TriStart DHA HUMAN PRESCRIPTION DRUG LABEL 15 15370-250 CAPSULE, LIQUID FILLED 200 ug ORAL UNAPPROVED DRUG OTHER 12 sections
Potassium Iodide HUMAN PRESCRIPTION DRUG LABEL 1 16477-601 SOLUTION 1 g ORAL unapproved drug other 18 sections
IODINE HUMAN OTC DRUG LABEL 2 16638-166 SOLUTION 0.20 g TOPICAL OTC monograph not final 9 sections
SSKI HUMAN PRESCRIPTION DRUG LABEL 1 17856-0114 SOLUTION 1 g ORAL UNAPPROVED DRUG OTHER 18 sections
PNV-Select HUMAN PRESCRIPTION DRUG LABEL 18 42192-320 TABLET, FILM COATED 150 ug ORAL unapproved drug other 10 sections
PNV-Omega HUMAN PRESCRIPTION DRUG LABEL 13 42192-332 CAPSULE, GELATIN COATED 150 ug ORAL unapproved drug other 12 sections
Strong Iodine Solution HUMAN PRESCRIPTION DRUG LABEL 2 48433-230 SOLUTION/ DROPS 1400 mg ORAL unapproved drug other 11 sections
ThyroSafe HUMAN OTC DRUG LABEL 1 50633-910 TABLET 65 mg ORAL ANDA 10 sections
NESTABSPrenatal Multi-vitamin/Mineral Supplement HUMAN PRESCRIPTION DRUG LABEL 15 50967-219 TABLET, FILM COATED 100 ug ORAL unapproved drug other 8 sections
IOSAT HUMAN OTC DRUG LABEL 1 51803-001 TABLET 130 mg ORAL NDA 16 sections
IOSAT HUMAN OTC DRUG LABEL 1 51803-001 TABLET 130 mg ORAL NDA 16 sections
IOSAT HUMAN OTC DRUG LABEL 1 51803-002 TABLET 65 mg ORAL NDA 16 sections
IOSAT HUMAN OTC DRUG LABEL 1 51803-002 TABLET 65 mg ORAL NDA 16 sections
Hay Fever HUMAN OTC DRUG LABEL 55 55714-2562 LIQUID 15 [hp_X] ORAL unapproved homeopathic 10 sections
BronCare HUMAN OTC DRUG LABEL 29 55714-4840 PELLET 15 [hp_X] ORAL unapproved homeopathic 10 sections
HBP HUMAN OTC DRUG LABEL 22 55714-4841 LIQUID 15 [hp_X] ORAL unapproved homeopathic 10 sections
CS Bone HUMAN OTC DRUG LABEL 11 57955-0211 LIQUID 10 [hp_X] ORAL unapproved homeopathic 9 sections
Prenatrix HUMAN PRESCRIPTION DRUG LABEL 20 59088-166 TABLET 150 ug ORAL unapproved drug other 13 sections
Prenatryl HUMAN PRESCRIPTION DRUG LABEL 20 59088-169 TABLET 150 ug ORAL unapproved drug other 13 sections
Prometa HUMAN PRESCRIPTION DRUG LABEL 20 59088-172 TABLET 150 ug ORAL unapproved drug other 13 sections