magnesium oxide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4293 1309-48-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • magnesium oxide
Magnesium oxide (MgO). An inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses.
  • Molecular weight: 40.30
  • Formula: MgO
  • CLOGP:
  • LIPINSKI: None
  • HAC: 1
  • HDO: 0
  • TPSA: 17.07
  • ALOGS:
  • ROTB: 0

Drug dosage:

DoseUnitRoute
7 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 22, 1982 FDA BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypermagnesaemia 246.03 41.75 28 168 120 2357769
Completed suicide 78.80 41.75 22 174 21012 2336877
Cardio-respiratory arrest 60.14 41.75 15 181 9131 2348758
Acute kidney injury 51.47 41.75 17 179 28105 2329784

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypermagnesaemia 111.37 45.99 13 132 55 1746581
Diarrhoea 72.88 45.99 27 118 53825 1692811

Pharmacologic Action:

SourceCodeDescription
ATC A02AA02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
ANTACIDS
Magnesium compounds
ATC A06AD02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Osmotically acting laxatives
ATC A12CC10 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
OTHER MINERAL SUPPLEMENTS
Magnesium
MeSH PA D000863 Antacids
MeSH PA D005765 Gastrointestinal Agents
CHEBI has role CHEBI:33287 fertilizer
CHEBI has role CHEBI:65265 antacid

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypocalcemia indication 5291005
Constipation indication 14760008 DOID:2089
Osteoporosis indication 64859006 DOID:11476
Postmenopausal osteoporosis indication 102447009
Indigestion indication 162031009
Hypomagnesemia indication 190855004
Incomplete passage of stool indication 249515001
Peptic ulcer contraindication 13200003 DOID:750
Bipolar disorder contraindication 13746004 DOID:3312
Hyperkalemia contraindication 14140009
Hypocupremia contraindication 19577007
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Metabolic acidosis contraindication 59455009
Diarrhea contraindication 62315008
Blood coagulation disorder contraindication 64779008 DOID:1247
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypercalciuria contraindication 71938000
Gastrointestinal hemorrhage contraindication 74474003
Phototoxicity contraindication 84326006
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Neoplasm of endometrium contraindication 123844007 DOID:1380
Gastrointestinal obstruction contraindication 126765001
Seizure disorder contraindication 128613002
Impaired renal function disorder contraindication 197663003
Osteolysis contraindication 203522001
Hypomania contraindication 231496004
Gastroparesis contraindication 235675006
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Endometrial carcinoma contraindication 254878006 DOID:2871
Esophageal dysmotility contraindication 266434009 DOID:9192
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Primary adrenocortical insufficiency contraindication 373662000
Ketoacidosis in diabetes mellitus contraindication 420422005 DOID:1837
Carcinoma of female breast contraindication 447782002
Genitourinary Tract Infections contraindication
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication
Esophageal Compression contraindication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
3.5GM/BOT CLENPIQ FERRING PHARMS INC N209589 Nov. 28, 2017 RX SOLUTION ORAL 9827231 June 26, 2034 FOR CLEANSING THE LARGE INTESTINE AS A PREPARATION FOR COLONOSCOPY

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
3.5GM/PACKET PREPOPIK FERRING PHARMS INC N202535 July 16, 2012 DISCN FOR SOLUTION ORAL Aug. 15, 2021 NEW PATIENT POPULATION

Bioactivity Summary:

None

External reference:

IDSource
4020248 VUID
N0000148146 NUI
C0024477 UMLSCUI
D01167 KEGG_DRUG
3A3U0GI71G UNII
419521006 SNOMEDCT_US
4020248 VANDF
4017717 VANDF
4017641 VANDF
5585 MMSL
6582 RXNORM
66389008 SNOMEDCT_US
5015 MMSL
d03797 MMSL
42624 MMSL
000788 NDDF
002435 NDDF
CHEMBL1200572 ChEMBL_ID
DB01377 DRUGBANK_ID
CHEBI:31794 CHEBI
D008277 MESH_DESCRIPTOR_UI
14792 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Calcemin Advance HUMAN OTC DRUG LABEL 4 0280-0272 TABLET, FILM COATED 40 mg ORAL Export only 1 sections
Calcemin Silver HUMAN OTC DRUG LABEL 2 0280-0273 TABLET, FILM COATED 40 mg ORAL Export only 1 sections
Magnesium Oxide HUMAN OTC DRUG LABEL 1 0603-0209 TABLET 400 mg ORAL OTC MONOGRAPH FINAL 7 sections
Select-OB Plus DHA HUMAN PRESCRIPTION DRUG LABEL 15 0642-0075 KIT 25 mg None Unapproved drug other 10 sections
Vitafol HUMAN PRESCRIPTION DRUG LABEL 16 0642-0093 CAPSULE, LIQUID FILLED 20 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 13 0642-0120 TABLET, CHEWABLE 25 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Strovite One HUMAN PRESCRIPTION DRUG LABEL 17 0642-0207 TABLET 50 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 16 0642-7473 CAPSULE, LIQUID FILLED 20 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 11 0682-1570 CAPSULE 25 mg ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 15 0682-3001 TABLET, COATED 50 mg ORAL UNAPPROVED DRUG OTHER 9 sections
Magnesium Oxide HUMAN OTC DRUG LABEL 1 10135-583 TABLET 400 mg ORAL OTC MONOGRAPH FINAL 9 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 12 15370-100 LIQUID 10 mg ORAL UNAPPROVED DRUG OTHER 9 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 12 15370-101 LIQUID 12 mg ORAL UNAPPROVED DRUG OTHER 9 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 13 15370-103 TABLET, CHEWABLE 15 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 13 15370-104 TABLET, CHEWABLE 15 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 13 15370-105 TABLET, CHEWABLE 15 mg ORAL UNAPPROVED DRUG OTHER 10 sections
TriStart DHA HUMAN PRESCRIPTION DRUG LABEL 15 15370-250 CAPSULE, LIQUID FILLED 30 mg ORAL UNAPPROVED DRUG OTHER 11 sections
PNV-Select HUMAN PRESCRIPTION DRUG LABEL 17 42192-320 TABLET, FILM COATED 30 ug ORAL unapproved drug other 11 sections
PNV-Omega HUMAN PRESCRIPTION DRUG LABEL 13 42192-332 CAPSULE, GELATIN COATED 45 mg ORAL unapproved drug other 9 sections
Bal-Care DHA HUMAN PRESCRIPTION DRUG LABEL 16 42546-180 KIT 25 mg None unapproved drug other 4 sections
Bal-Care DHA Essential HUMAN PRESCRIPTION DRUG LABEL 16 42546-185 KIT 25 mg None unapproved drug other 4 sections
PR Natal 400 ec HUMAN PRESCRIPTION DRUG LABEL 14 42546-517 KIT 25 mg None unapproved drug other 11 sections
PR Natal 430 ec HUMAN PRESCRIPTION DRUG LABEL 14 42546-518 KIT 25 mg None unapproved drug other 11 sections
PR Natal 400 HUMAN PRESCRIPTION DRUG LABEL 14 42546-811 KIT 25 mg None unapproved drug other 11 sections
PR Natal 430 HUMAN PRESCRIPTION DRUG LABEL 14 42546-812 KIT 25 mg None unapproved drug other 11 sections
Duet DHA HUMAN PRESCRIPTION DRUG LABEL 14 44118-807 KIT 25 mg ORAL unapproved drug other 10 sections
Migralex HUMAN OTC DRUG LABEL 2 49886-001 TABLET, COATED 75 mg ORAL OTC monograph not final 12 sections
Nestabs ONE HUMAN PRESCRIPTION DRUG LABEL 9 50967-410 CAPSULE, GELATIN COATED 15 mg ORAL unapproved drug other 12 sections
Magnesium Oxide HUMAN OTC DRUG LABEL 1 53808-0684 TABLET 400 mg ORAL OTC MONOGRAPH FINAL 7 sections
Magnesium Oxide HUMAN OTC DRUG LABEL 1 54738-973 TABLET 400 mg ORAL OTC monograph final 8 sections