magnesium oxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4293 1309-48-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • magnesium oxide
Magnesium oxide (MgO). An inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses.
  • Molecular weight: 40.30
  • Formula: MgO
  • CLOGP: -1.32
  • LIPINSKI: None
  • HAC: 1
  • HDO: 0
  • TPSA: 17.07
  • ALOGS:
  • ROTB: 0

Drug dosage:

DoseUnitRoute
7 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 22, 1982 FDA BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1708.29 10.28 4403 539384 179323 62765912
Systemic lupus erythematosus 1613.67 10.28 4677 539110 204241 62740994
Glossodynia 1424.90 10.28 4050 539737 174826 62770409
Hand deformity 1159.87 10.28 3496 540291 155961 62789274
Arthropathy 1056.63 10.28 4394 539393 230398 62714837
Wound 959.42 10.28 3328 540459 159935 62785300
Abdominal discomfort 956.14 10.28 5332 538455 315553 62629682
Alopecia 943.68 10.28 5514 538273 332022 62613213
Completed suicide 876.63 10.28 108 543679 145565 62799670
Maternal exposure during pregnancy 864.25 10.28 3954 539833 216108 62729127
Rheumatoid arthritis 831.69 10.28 4330 539457 249489 62695746
Toxicity to various agents 784.87 10.28 583 543204 246667 62698568
Synovitis 769.27 10.28 3406 540381 183512 62761723
Anti-cyclic citrullinated peptide antibody positive 724.53 10.28 2417 541370 113795 62831440
Pericarditis 723.59 10.28 2625 541162 128954 62816281
Infusion related reaction 694.37 10.28 4025 539762 241496 62703739
Contraindicated product administered 690.66 10.28 3681 540106 213967 62731268
Discomfort 683.36 10.28 3043 540744 164331 62780904
Swelling 662.64 10.28 4330 539457 271048 62674187
Joint swelling 593.29 10.28 4813 538974 322853 62622382
Pain 496.80 10.28 8996 534791 731632 62213603
Death 484.18 10.28 1618 542169 372763 62572472
Rheumatoid factor positive 459.55 10.28 1679 542108 82727 62862508
Duodenal ulcer perforation 458.27 10.28 1715 542072 85494 62859741
Product use issue 441.58 10.28 3317 540470 217203 62728032
Helicobacter infection 441.33 10.28 1768 542019 91017 62854218
Intentional overdose 413.25 10.28 69 543718 74083 62871152
Drug interaction 406.63 10.28 845 542942 228286 62716949
Hepatic enzyme increased 389.65 10.28 3016 540771 199312 62745923
Drug abuse 385.73 10.28 76 543711 72442 62872793
Arthralgia 323.41 10.28 6751 537036 562959 62382276
Psoriatic arthropathy 300.77 10.28 1564 542223 89956 62855279
Musculoskeletal stiffness 293.39 10.28 2636 541151 181982 62763253
Therapeutic product effect decreased 290.15 10.28 2725 541062 190462 62754773
Drug intolerance 274.92 10.28 3934 539853 304727 62640508
Exposure during pregnancy 261.10 10.28 2248 541539 153299 62791936
Suicide attempt 250.19 10.28 104 543683 60814 62884421
Treatment failure 247.64 10.28 2701 541086 196342 62748893
Hip arthroplasty 228.91 10.28 911 542876 46735 62898500
Knee arthroplasty 224.18 10.28 990 542797 53216 62892019
Overdose 210.24 10.28 417 543370 114661 62830574
Device expulsion 204.86 10.28 28 543759 34894 62910341
Cardiac arrest 204.33 10.28 297 543490 92248 62852987
Rheumatic fever 199.68 10.28 815 542972 42296 62902939
Hypersensitivity 193.32 10.28 3551 540236 289134 62656101
Impaired healing 187.46 10.28 1511 542276 101031 62844204
Nasopharyngitis 176.75 10.28 3110 540677 251147 62694088
Sedation 174.96 10.28 57 543730 38752 62906483
Swollen joint count increased 174.49 10.28 691 543096 35363 62909872
Acute kidney injury 171.99 10.28 1436 542351 261979 62683256
Constipation 169.63 10.28 1178 542609 223765 62721470
Anxiety 166.13 10.28 1135 542652 216406 62728829
Disease progression 163.46 10.28 523 543264 122235 62823000
Hypotension 161.74 10.28 1523 542264 271081 62674154
Folliculitis 159.11 10.28 1090 542697 69227 62876008
Red blood cell sedimentation rate abnormal 159.06 10.28 450 543337 19332 62925903
Lactic acidosis 156.19 10.28 66 543721 38221 62907014
Asthenia 156.01 10.28 2329 541458 381275 62563960
Muscle injury 155.09 10.28 1025 542762 64320 62880915
Nausea 154.95 10.28 5874 537913 848597 62096638
Diarrhoea 152.88 10.28 4817 538970 710549 62234686
Tremor 149.77 10.28 603 543184 131636 62813599
Blister 149.69 10.28 1736 542051 128078 62817157
Drug hypersensitivity 145.03 10.28 1834 541953 308853 62636382
Neutropenia 142.73 10.28 895 542892 174110 62771125
Hyperhidrosis 142.47 10.28 461 543326 107375 62837860
Bradycardia 139.25 10.28 259 543528 72968 62872267
Agitation 137.65 10.28 186 543601 59571 62885664
Dyspnoea 137.60 10.28 4468 539319 656845 62288390
Sleep disorder due to general medical condition, insomnia type 136.21 10.28 839 542948 51378 62893857
Sickle cell anaemia with crisis 135.54 10.28 209 543578 5794 62939441
Electrocardiogram QT prolonged 127.54 10.28 195 543592 59335 62885900
Depressed level of consciousness 126.71 10.28 210 543577 61868 62883367
Irritable bowel syndrome 125.29 10.28 1166 542621 81246 62863989
Sopor 124.85 10.28 20 543767 22144 62923091
Intentional self-injury 124.44 10.28 33 543754 25654 62919581
Somnolence 122.09 10.28 962 542825 177723 62767512
C-reactive protein abnormal 120.45 10.28 741 543046 45355 62899880
Drug reaction with eosinophilia and systemic symptoms 120.40 10.28 70 543717 33766 62911469
Syncope 111.53 10.28 571 543216 116814 62828421
Cognitive disorder 110.98 10.28 192 543595 55623 62889612
Hyponatraemia 108.21 10.28 541 543246 111359 62833876
Febrile neutropenia 107.06 10.28 586 543201 117863 62827372
Lower respiratory tract infection 106.43 10.28 1658 542129 130649 62814586
Rash 106.26 10.28 5844 537943 555027 62390208
Renal failure 105.82 10.28 583 543204 117069 62828166
Dizziness 105.32 10.28 2840 540947 427085 62518150
Coma 105.26 10.28 248 543539 64116 62881119
Myalgia 103.30 10.28 782 543005 145747 62799488
Vision blurred 100.42 10.28 425 543362 91499 62853736
Blood cholesterol increased 100.24 10.28 1239 542548 92793 62852442
Neuropathy peripheral 99.65 10.28 568 543219 113099 62832136
Tachycardia 99.56 10.28 598 543189 117558 62827677
Balance disorder 99.36 10.28 379 543408 84043 62861192
Type 2 diabetes mellitus 99.27 10.28 908 542879 62960 62882275
Drug withdrawal syndrome 98.56 10.28 55 543732 27139 62918096
Condition aggravated 98.50 10.28 4298 539489 397919 62547316
Multiple sclerosis relapse 98.00 10.28 165 543622 48313 62896922
Respiratory arrest 97.06 10.28 82 543705 32563 62912672
Osteoarthritis 96.41 10.28 1244 542543 94099 62851136
Liver injury 95.89 10.28 864 542923 59656 62885579
Drug dependence 95.47 10.28 45 543742 24438 62920797
Serotonin syndrome 94.27 10.28 65 543722 28617 62916618
Feeling abnormal 92.69 10.28 818 542969 147574 62797661
Arthritis 91.83 10.28 1449 542338 114472 62830763
Intentional product use issue 87.87 10.28 1562 542225 126330 62818905
Vomiting 87.19 10.28 3912 539875 555705 62389530
Angioedema 86.53 10.28 175 543612 47790 62897445
Product quality issue 86.33 10.28 108 543679 35757 62909478
Fibromyalgia 85.86 10.28 1060 542727 79360 62865875
No adverse event 85.49 10.28 139 543648 41266 62903969
Drug resistance 85.13 10.28 45 543742 22888 62922347
Live birth 84.81 10.28 439 543348 25191 62920044
Chest discomfort 84.73 10.28 572 543215 109397 62835838
C-reactive protein increased 83.20 10.28 1205 542582 93502 62851733
Intentional product misuse 82.13 10.28 258 543529 60659 62884576
Pregnancy 80.93 10.28 567 543220 36269 62908966
Disturbance in attention 80.93 10.28 126 543661 38063 62907172
Metabolic acidosis 80.82 10.28 165 543622 44904 62900331
Cardio-respiratory arrest 80.79 10.28 254 543533 59705 62885530
Fatigue 79.30 10.28 8722 535065 879306 62065929
Seizure 78.97 10.28 740 543047 131894 62813341
Drug ineffective for unapproved indication 77.45 10.28 107 543680 33956 62911279
Blood pressure diastolic abnormal 73.02 10.28 282 543505 14260 62930975
Myocardial infarction 72.83 10.28 528 543259 99365 62845870
Stomatitis 72.75 10.28 1627 542160 137098 62808137
Ill-defined disorder 71.72 10.28 1040 542747 80715 62864520
Creatinine renal clearance decreased 71.68 10.28 25 543762 16283 62928952
Joint effusion 71.58 10.28 313 543474 16747 62928488
Product dose omission issue 71.33 10.28 1497 542290 232816 62712419
Asthma 71.18 10.28 723 543064 126838 62818397
Hepatocellular injury 70.68 10.28 78 543709 27303 62917932
Sedation complication 70.37 10.28 16 543771 13806 62931429
Blood pressure systolic abnormal 70.03 10.28 263 543524 13123 62932112
Rhabdomyolysis 69.76 10.28 172 543615 43779 62901456
Emotional distress 69.35 10.28 107 543680 32442 62912793
Red blood cell sedimentation rate increased 68.70 10.28 626 543161 43356 62901879
Flushing 67.54 10.28 372 543415 74715 62870520
Hypoglycaemia 67.27 10.28 275 543512 59790 62885445
Malignant neoplasm progression 66.88 10.28 420 543367 81701 62863534
Blood pressure fluctuation 65.75 10.28 646 543141 45671 62899564
Disability assessment scale score increased 65.33 10.28 107 543680 3126 62942109
Thrombocytopenia 65.04 10.28 907 542880 150250 62794985
Cholestasis 64.41 10.28 95 543692 29339 62915896
Ejection fraction decreased 64.08 10.28 58 543729 22274 62922961
Suicidal ideation 63.69 10.28 296 543491 62125 62883110
Neoplasm progression 63.11 10.28 136 543651 36292 62908943
Abortion spontaneous 63.03 10.28 650 543137 46545 62898690
Depression 62.87 10.28 1245 542542 195247 62749988
Orthostatic hypotension 62.64 10.28 135 543652 36025 62909210
Contusion 62.59 10.28 1706 542081 148338 62796897
Muscle spasticity 62.07 10.28 57 543730 21737 62923498
Anaphylactic reaction 61.94 10.28 323 543464 65777 62879458
Multiple organ dysfunction syndrome 60.37 10.28 265 543522 56487 62888748
Poisoning 60.22 10.28 21 543766 13679 62931556
Pulmonary fibrosis 59.85 10.28 562 543225 39247 62905988
Urticaria 59.76 10.28 1029 542758 164773 62780462
Foot deformity 59.59 10.28 426 543361 27427 62917808
Fluid retention 58.57 10.28 287 543500 59399 62885836
Hypermagnesaemia 56.50 10.28 55 543732 931 62944304
Bone pain 56.40 10.28 258 543529 54383 62890852
Encephalopathy 56.07 10.28 158 543629 38462 62906773
Muscle spasms 55.66 10.28 971 542816 155179 62790056
Hepatic failure 55.45 10.28 141 543646 35515 62909720
Cardiac failure 55.37 10.28 492 543295 88650 62856585
Juvenile idiopathic arthritis 55.32 10.28 101 543686 3225 62942010
Mydriasis 54.88 10.28 17 543770 11939 62933296
Insomnia 54.65 10.28 1414 542373 213838 62731397
Wrong technique in product usage process 54.36 10.28 312 543475 62028 62883207
Grip strength decreased 54.32 10.28 352 543435 21935 62923300
Hallucination 54.13 10.28 263 543524 54554 62890681
Blood pressure systolic increased 52.43 10.28 629 543158 46768 62898467
Device dislocation 52.40 10.28 87 543700 25618 62919617
Pulmonary embolism 51.67 10.28 696 543091 115988 62829247
Peripheral swelling 51.52 10.28 2778 541009 263164 62682071
Joint laxity 50.40 10.28 82 543705 2382 62942853
Blood glucose increased 50.40 10.28 466 543321 83290 62861945
Cardiac failure congestive 50.28 10.28 527 543260 91906 62853329
Bone erosion 50.24 10.28 291 543496 17426 62927809
Osteoporosis 50.12 10.28 729 543058 56609 62888626
Unresponsive to stimuli 50.09 10.28 137 543650 33679 62911556
Respiratory failure 49.78 10.28 595 543192 101263 62843972
Blood calcium decreased 49.01 10.28 95 543692 26356 62918879
Metastases to bone 48.82 10.28 65 543722 20954 62924281
Infection 48.46 10.28 2414 541373 226759 62718476
Drug tolerance decreased 48.25 10.28 285 543502 17188 62928047
Caesarean section 47.81 10.28 279 543508 16753 62928482
Headache 47.67 10.28 4724 539063 628517 62316718
Palpitations 47.66 10.28 679 543108 112091 62833144
Hypoxia 47.55 10.28 308 543479 59484 62885751
Speech disorder 47.40 10.28 183 543604 40446 62904789
Cerebrovascular accident 47.23 10.28 646 543141 107378 62837857
Joint destruction 47.15 10.28 139 543648 6113 62939122
Disorientation 47.13 10.28 176 543611 39276 62905959
Dysarthria 46.92 10.28 197 543590 42514 62902721
Basal cell carcinoma 46.59 10.28 404 543383 27587 62917648
Hepatotoxicity 46.40 10.28 162 543625 36879 62908356
Pain in jaw 46.32 10.28 203 543584 43293 62901942
Premature labour 46.21 10.28 221 543566 12283 62932952
Device difficult to use 46.20 10.28 26 543761 12770 62932465
Hyperglycaemia 46.06 10.28 193 543594 41674 62903561
Memory impairment 45.76 10.28 623 543164 103635 62841600
Blood pressure diastolic decreased 45.55 10.28 342 543445 22364 62922871
Joint range of motion decreased 45.40 10.28 451 543336 31977 62913258
Psychotic disorder 45.37 10.28 95 543692 25617 62919618
Product use in unapproved indication 45.28 10.28 1177 542610 177903 62767332
Accidental exposure to product 45.27 10.28 105 543682 27300 62917935
Diabetic ketoacidosis 45.04 10.28 66 543721 20439 62924796
Vertigo 44.87 10.28 314 543473 59573 62885662
Suspected suicide 44.46 10.28 3 543784 6565 62938670
Hypothermia 44.34 10.28 31 543756 13550 62931685
Polyneuropathy 44.16 10.28 36 543751 14553 62930682
Inflammation 44.08 10.28 968 542819 81305 62863930
Psoriasis 44.04 10.28 1015 542772 85942 62859293
Bronchospasm 43.75 10.28 50 543737 17230 62928005
COVID-19 43.68 10.28 693 543094 112410 62832825
Product administration error 43.65 10.28 78 543709 22319 62922916
Chest pain 43.25 10.28 1465 542322 214494 62730741
Polyarthritis 43.22 10.28 187 543600 9959 62935276
Loss of personal independence in daily activities 42.79 10.28 1114 542673 96176 62849059
Hypomania 42.54 10.28 3 543784 6327 62938908
Leukopenia 42.31 10.28 440 543347 76850 62868385
Neurotoxicity 42.11 10.28 50 543737 16940 62928295
Mental status changes 42.05 10.28 185 543602 39414 62905821
Respiratory disorder 41.25 10.28 183 543604 38899 62906336
Acute hepatic failure 41.24 10.28 58 543729 18269 62926966
Back pain 40.87 10.28 1847 541940 262298 62682937
Dysphagia 40.82 10.28 524 543263 88061 62857174
Weight increased 40.61 10.28 2672 541115 258120 62687115
Torsade de pointes 40.35 10.28 33 543754 13318 62931917
Rheumatoid nodule 40.02 10.28 268 543519 16887 62928348
Posterior reversible encephalopathy syndrome 39.92 10.28 54 543733 17291 62927944
Gestational diabetes 39.88 10.28 160 543627 8236 62936999
Drug ineffective 39.87 10.28 9799 533988 1034966 61910269
Sinusitis 39.87 10.28 2347 541440 224306 62720929
Hospitalisation 39.68 10.28 502 543285 84579 62860656
Anaphylactic shock 39.48 10.28 90 543697 23543 62921692
Drug level increased 39.28 10.28 85 543702 22651 62922584
Dysgeusia 39.01 10.28 237 543550 46473 62898762
Withdrawal syndrome 38.65 10.28 70 543717 19927 62925308
Lethargy 38.45 10.28 301 543486 55706 62889529
Disability 38.32 10.28 279 543508 18068 62927167
Palmar-plantar erythrodysaesthesia syndrome 38.16 10.28 88 543699 22927 62922308
Ventricular tachycardia 37.67 10.28 71 543716 19908 62925327
Neck deformity 37.31 10.28 66 543721 2055 62943180
Paraesthesia 37.24 10.28 1041 542746 155925 62789310
Respiratory distress 37.04 10.28 157 543630 33794 62911441
Coagulopathy 37.01 10.28 75 543712 20469 62924766
Rash erythematous 36.92 10.28 213 543574 42297 62902938
Disease recurrence 36.88 10.28 120 543667 27910 62917325
Depressed mood 36.75 10.28 198 543589 39993 62905242
Acute generalised exanthematous pustulosis 36.68 10.28 25 543762 11074 62934161
Dyspnoea exertional 36.49 10.28 335 543452 59967 62885268
Extrapyramidal disorder 36.36 10.28 36 543751 13248 62931987
Dry skin 36.19 10.28 312 543475 56575 62888660
Muscle twitching 36.12 10.28 71 543716 19597 62925638
Haemorrhage 36.07 10.28 341 543446 60681 62884554
Chronic kidney disease 36.02 10.28 234 543553 45164 62900071
Tuberculosis 35.69 10.28 190 543597 11021 62934214
Hemiparesis 35.48 10.28 93 543694 23189 62922046
Respiratory depression 35.47 10.28 39 543748 13676 62931559
Injection site pruritus 35.34 10.28 563 543224 44553 62900682
Foetal exposure during pregnancy 35.28 10.28 424 543363 31538 62913697
Irritability 34.92 10.28 146 543641 31548 62913687
Lip swelling 34.91 10.28 142 543645 30921 62914314
Accidental overdose 34.85 10.28 94 543693 23215 62922020
Arrhythmia 34.82 10.28 188 543599 37952 62907283
Shock 34.80 10.28 95 543692 23368 62921867
Abnormal behaviour 34.67 10.28 83 543704 21343 62923892
Adverse event 34.65 10.28 790 542997 66769 62878466
Multiple fractures 34.56 10.28 156 543631 8462 62936773
Skin exfoliation 34.29 10.28 222 543565 42880 62902355
Dehydration 34.22 10.28 1178 542609 172176 62773059
Panic attack 34.19 10.28 89 543698 22242 62922993
Loss of consciousness 34.06 10.28 761 543026 117360 62827875
Exposure to toxic agent 33.93 10.28 4 543783 5583 62939652
Anaemia 33.86 10.28 2113 541674 291317 62653918
Prescribed underdose 33.71 10.28 396 543391 29293 62915942
Obstructive airways disorder 33.64 10.28 80 543707 20619 62924616
Chills 33.39 10.28 728 543059 112650 62832585
Thrombotic microangiopathy 33.31 10.28 25 543762 10536 62934699
Immune reconstitution inflammatory syndrome 33.14 10.28 6 543781 6078 62939157
Metastases to liver 32.65 10.28 99 543688 23540 62921695
Deep vein thrombosis 32.50 10.28 513 543274 83287 62861948
Hyperkalaemia 32.42 10.28 302 543485 53901 62891334
Dystonia 31.83 10.28 43 543744 13776 62931459
Infective pulmonary exacerbation of cystic fibrosis 31.71 10.28 18 543769 8799 62936436
Restlessness 31.64 10.28 137 543650 29316 62915919
Joint dislocation 31.63 10.28 272 543515 18528 62926707
Forced expiratory volume decreased 31.60 10.28 3 543784 4965 62940270
Swollen tongue 31.51 10.28 172 543615 34628 62910607
Nodule 31.19 10.28 296 543491 20730 62924505
Haematotoxicity 31.14 10.28 21 543766 9355 62935880
Atrial fibrillation 30.97 10.28 761 543026 115875 62829360
Laryngitis 30.96 10.28 250 543537 16717 62928518
Injection site erythema 30.87 10.28 932 542855 82242 62862993
International normalised ratio increased 30.72 10.28 252 543535 46173 62899062
Crying 30.66 10.28 100 543687 23243 62921992
Fear 30.64 10.28 55 543732 15711 62929524
Nightmare 30.55 10.28 75 543712 19119 62926116
Substance abuse 30.32 10.28 3 543784 4804 62940431
Eosinophilia 30.23 10.28 97 543690 22659 62922576
Cytomegalovirus infection 30.20 10.28 86 543701 20866 62924369
Bradyphrenia 30.17 10.28 11 543776 6969 62938266
Maternal exposure before pregnancy 30.02 10.28 137 543650 7466 62937769
Maternal drugs affecting foetus 29.96 10.28 106 543681 5136 62940099
Product adhesion issue 29.62 10.28 3 543784 4716 62940519
Pancreatitis acute 29.40 10.28 126 543661 27040 62918195
Enthesopathy 28.81 10.28 148 543639 8466 62936769
Uterine perforation 28.40 10.28 12 543775 6951 62938284
Heart rate decreased 28.32 10.28 548 543239 45012 62900223
Aphasia 28.31 10.28 166 543621 32834 62912401
Femur fracture 28.30 10.28 509 543278 41247 62903988
Visual impairment 27.91 10.28 532 543255 83914 62861321
Complication of device insertion 27.84 10.28 15 543772 7549 62937686
Cardiogenic shock 27.81 10.28 71 543716 17861 62927374
Cough 27.67 10.28 2145 541642 290598 62654637
Agranulocytosis 27.56 10.28 116 543671 25018 62920217
Latent tuberculosis 27.53 10.28 66 543721 2561 62942674
Blood pressure diastolic increased 27.47 10.28 163 543624 9847 62935388
Diabetes mellitus inadequate control 27.44 10.28 55 543732 15071 62930164
Pulmonary arterial hypertension 27.44 10.28 100 543687 22477 62922758
Post transplant lymphoproliferative disorder 27.32 10.28 5 543782 5026 62940209
Cholecystitis chronic 27.31 10.28 29 543758 10332 62934903
Complication associated with device 27.29 10.28 66 543721 16912 62928323
Ventricular septal defect 27.18 10.28 91 543696 4287 62940948
Ischaemic stroke 27.16 10.28 72 543715 17885 62927350
Akathisia 27.15 10.28 23 543764 9123 62936112
Status epilepticus 27.11 10.28 56 543731 15177 62930058
Fall 26.96 10.28 2945 540842 389389 62555846
Myelosuppression 26.86 10.28 108 543679 23595 62921640
Skin ulcer 26.84 10.28 518 543269 42527 62902708
Device use error 26.79 10.28 8 543779 5753 62939482
Infusion site pain 26.78 10.28 66 543721 16803 62928432
Wheelchair user 26.56 10.28 116 543671 6203 62939032
Tenderness 26.46 10.28 303 543484 22275 62922960
Breast cancer stage I 26.34 10.28 13 543774 6876 62938359
Feeling hot 26.21 10.28 290 543497 50064 62895171
Peripheral venous disease 26.08 10.28 224 543563 15253 62929982
Haematoma 25.87 10.28 183 543604 34637 62910598
Venoocclusive liver disease 25.84 10.28 5 543782 4830 62940405
Blood creatine phosphokinase increased 25.62 10.28 154 543633 30276 62914959
Limb deformity 25.57 10.28 84 543703 3918 62941317
Anhedonia 25.42 10.28 34 543753 10940 62934295
General physical health deterioration 25.42 10.28 2029 541758 199373 62745862
Personality disorder 25.38 10.28 9 543778 5802 62939433
Dyskinesia 25.37 10.28 165 543622 31837 62913398
Neuroleptic malignant syndrome 25.33 10.28 40 543747 12016 62933219
Paradoxical drug reaction 25.15 10.28 3 543784 4149 62941086
Small for dates baby 25.12 10.28 80 543707 3671 62941564
Mania 25.08 10.28 42 543745 12325 62932910
Schizophrenia 24.98 10.28 29 543758 9923 62935312
Second primary malignancy 24.86 10.28 19 543768 7934 62937301
Joint stiffness 24.82 10.28 500 543287 41369 62903866
Ankylosing spondylitis 24.65 10.28 164 543623 10310 62934925
Macular degeneration 24.62 10.28 116 543671 24260 62920975
Lupus-like syndrome 24.54 10.28 219 543568 15076 62930159
Multiple allergies 24.34 10.28 51 543736 13751 62931484
Temperature regulation disorder 24.33 10.28 11 543776 6121 62939114
Face oedema 24.25 10.28 90 543697 20122 62925113
Malignant mediastinal neoplasm 24.17 10.28 44 543743 1402 62943833
Pulmonary oedema 24.03 10.28 328 543459 54545 62890690
Obesity 23.92 10.28 375 543412 29577 62915658
Facet joint syndrome 23.88 10.28 182 543605 11956 62933279
Angina pectoris 23.88 10.28 155 543632 29923 62915312
Abdominal distension 23.85 10.28 562 543225 86053 62859182
Acute respiratory failure 23.82 10.28 185 543602 34300 62910935
Pancreatitis 23.79 10.28 287 543500 48768 62896467
Brain oedema 23.76 10.28 54 543733 14141 62931094
Sinus tachycardia 23.63 10.28 117 543670 24151 62921084
Off label use 23.62 10.28 5265 538522 669197 62276038
Premature rupture of membranes 23.59 10.28 95 543692 4898 62940337
Febrile bone marrow aplasia 23.54 10.28 17 543770 7308 62937927
Ventricular fibrillation 23.42 10.28 41 543746 11826 62933409
Transplant rejection 23.38 10.28 35 543752 10745 62934490
Unevaluable event 23.28 10.28 305 543482 51081 62894154
Hot flush 23.05 10.28 304 543483 50855 62894380
Gastrointestinal disorder 23.05 10.28 1359 542428 129880 62815355
Mental disorder 22.98 10.28 129 543658 25790 62919445
Infusion site swelling 22.91 10.28 30 543757 9740 62935495
Tenosynovitis 22.90 10.28 199 543588 13596 62931639
Tachypnoea 22.81 10.28 74 543713 17228 62928007
Acute graft versus host disease 22.80 10.28 5 543782 4423 62940812
Tenosynovitis stenosans 22.76 10.28 72 543715 3292 62941943
Body temperature decreased 22.62 10.28 270 543517 20049 62925186
Paralysis 22.60 10.28 31 543756 9869 62935366
Multiple-drug resistance 22.59 10.28 8 543779 5162 62940073
Injection site reaction 22.58 10.28 659 543128 57865 62887370
Aggression 22.47 10.28 114 543673 23384 62921851
Miosis 22.44 10.28 18 543769 7335 62937900
Renal impairment 22.23 10.28 581 543206 87774 62857461
Tardive dyskinesia 22.18 10.28 24 543763 8478 62936757
Pre-eclampsia 22.10 10.28 144 543643 8989 62936246
Gamma-glutamyltransferase increased 21.93 10.28 186 543601 33845 62911390
Red blood cell sedimentation rate 21.86 10.28 91 543696 4763 62940472
Psychomotor hyperactivity 21.82 10.28 36 543751 10627 62934608
Retinitis 21.81 10.28 108 543679 6088 62939147
Influenza like illness 21.77 10.28 422 543365 66402 62878833
Asphyxia 21.69 10.28 13 543774 6168 62939067
Lip dry 21.58 10.28 215 543572 15255 62929980
Affective disorder 21.46 10.28 13 543774 6133 62939102
Dislocation of vertebra 21.42 10.28 137 543650 8498 62936737
Pulmonary tuberculosis 21.39 10.28 86 543701 4431 62940804
Dysmorphism 21.23 10.28 55 543732 2241 62942994
Adjustment disorder with depressed mood 21.21 10.28 155 543632 10049 62935186
Localised infection 21.09 10.28 370 543417 29840 62915395
Hyperlipidaemia 21.04 10.28 91 543696 19480 62925755
Nervousness 21.02 10.28 167 543620 30812 62914423
Prescribed overdose 20.96 10.28 410 543377 33743 62911492
Coronary artery disease 20.85 10.28 177 543610 32200 62913035
Myoclonus 20.83 10.28 68 543719 15800 62929435
Labelled drug-drug interaction medication error 20.82 10.28 53 543734 13346 62931889
Smear cervix abnormal 20.80 10.28 64 543723 2882 62942353
Lymphoedema 20.79 10.28 43 543744 11649 62933586
Mobility decreased 20.78 10.28 1252 542535 119907 62825328
Nasal polyps 20.77 10.28 13 543774 6026 62939209
Complication of device removal 20.75 10.28 9 543778 5133 62940102
Infusion site erythema 20.73 10.28 43 543744 11636 62933599
Multiple sclerosis 20.70 10.28 123 543664 24249 62920986
Jaundice 20.64 10.28 156 543631 29095 62916140
Cyanosis 20.59 10.28 75 543712 16860 62928375
Maternal exposure timing unspecified 20.48 10.28 117 543670 6970 62938265
Anti-cyclic citrullinated peptide antibody 20.48 10.28 113 543674 6645 62938590
Bradypnoea 20.46 10.28 3 543784 3547 62941688
Leukocytosis 20.41 10.28 134 543653 25801 62919434
Sexual dysfunction 20.37 10.28 6 543781 4353 62940882
Pathogen resistance 20.37 10.28 15 543772 6383 62938852
Musculoskeletal pain 20.30 10.28 976 542811 91301 62853934
Visual acuity reduced 20.25 10.28 107 543680 21719 62923516
Tinnitus 20.25 10.28 201 543586 35427 62909808
Synovial fluid analysis 20.20 10.28 56 543731 2377 62942858
Mood altered 20.18 10.28 62 543725 14681 62930554
Urinary incontinence 20.18 10.28 176 543611 31838 62913397
Hereditary angioedema 20.12 10.28 21 543766 7541 62937694
Therapeutic response decreased 20.10 10.28 679 543108 60846 62884389
Therapy partial responder 19.99 10.28 38 543749 10620 62934615
Abdominal pain 19.84 10.28 2205 541582 291251 62653984
Injection site swelling 19.84 10.28 541 543246 47031 62898204
Haemophagocytic lymphohistiocytosis 19.83 10.28 38 543749 10589 62934646
Wound infection 19.82 10.28 275 543512 21135 62924100
Dermatitis atopic 19.74 10.28 33 543754 9691 62935544
Cardiotoxicity 19.69 10.28 26 543761 8412 62936823
Rotator cuff repair 19.61 10.28 51 543736 2083 62943152
Hepatic cytolysis 19.55 10.28 67 543720 15340 62929895
Cytopenia 19.52 10.28 44 543743 11557 62933678
Abdominal pain upper 19.43 10.28 1513 542274 204931 62740304
Toxic epidermal necrolysis 19.39 10.28 132 543655 25202 62920033
Cardiomyopathy 19.37 10.28 81 543706 17503 62927732
Placental disorder 19.35 10.28 41 543746 1463 62943772
Device breakage 19.24 10.28 44 543743 11498 62933737
Hypokalaemia 19.19 10.28 711 543076 103093 62842142
Product prescribing error 19.13 10.28 139 543648 26150 62919085
Muscle rigidity 19.04 10.28 44 543743 11456 62933779
Neck mass 19.02 10.28 71 543716 3532 62941703
Circulatory collapse 19.01 10.28 110 543677 21828 62923407
Product complaint 18.89 10.28 52 543735 12757 62932478
Body height below normal 18.87 10.28 51 543736 2132 62943103
Progressive multifocal leukoencephalopathy 18.87 10.28 53 543734 12918 62932317
Loose body in joint 18.85 10.28 37 543750 1249 62943986
Pancytopenia 18.82 10.28 1013 542774 95920 62849315
Anger 18.80 10.28 50 543737 12406 62932829
Cardiac disorder 18.73 10.28 314 543473 50502 62894733
Body temperature increased 18.64 10.28 216 543571 36976 62908259
Sepsis 18.63 10.28 1097 542690 152026 62793209
Food allergy 18.58 10.28 44 543743 11357 62933878
Swelling face 18.56 10.28 408 543379 63067 62882168
Rhinitis allergic 18.52 10.28 46 543741 11681 62933554
Toxic skin eruption 18.49 10.28 53 543734 12832 62932403
Product preparation error 18.48 10.28 15 543772 6077 62939158
Sleep apnoea syndrome 18.43 10.28 160 543627 28973 62916262
Pallor 18.41 10.28 170 543617 30398 62914837
Throat tightness 18.39 10.28 131 543656 24756 62920479
Schizoaffective disorder 18.38 10.28 4 543783 3558 62941677
Developmental hip dysplasia 18.35 10.28 38 543749 1334 62943901
Paranoia 18.30 10.28 46 543741 11633 62933602
Muscular weakness 18.20 10.28 859 542928 121494 62823741
Device issue 18.15 10.28 124 543663 23657 62921578
Rebound effect 18.14 10.28 8 543779 4518 62940717
Synovial cyst 18.11 10.28 152 543635 10281 62934954
Rash maculo-papular 18.10 10.28 180 543607 31716 62913519
Coordination abnormal 18.09 10.28 59 543728 13714 62931521
Catheter site erythema 18.04 10.28 7 543780 4269 62940966
Haematocrit decreased 18.03 10.28 453 543334 38887 62906348
Respiration abnormal 18.02 10.28 17 543770 6400 62938835
Foetal anticonvulsant syndrome 17.97 10.28 24 543763 581 62944654
Synovial disorder 17.91 10.28 48 543739 1997 62943238
Clostridium difficile colitis 17.90 10.28 103 543684 20466 62924769
Metastases to lung 17.89 10.28 53 543734 12697 62932538
Deep vein thrombosis postoperative 17.84 10.28 162 543625 11207 62934028
Catatonia 17.81 10.28 8 543779 4469 62940766
Spinal stenosis 17.81 10.28 201 543586 14724 62930511
Pregnancy with contraceptive device 17.74 10.28 9 543778 4685 62940550
Pulseless electrical activity 17.73 10.28 23 543764 7498 62937737
Interstitial lung disease 17.71 10.28 673 543114 61235 62884000
Pseudomonas infection 17.70 10.28 44 543743 11169 62934066
Hemiplegia 17.69 10.28 33 543754 9290 62935945
Renal tubular necrosis 17.68 10.28 48 543739 11830 62933405
Liver disorder 17.67 10.28 593 543194 53094 62892141
Cerebral haemorrhage 17.61 10.28 173 543614 30556 62914679
Stress cardiomyopathy 17.45 10.28 34 543753 9416 62935819
Sinus bradycardia 17.32 10.28 65 543722 14486 62930749
Ascites 17.28 10.28 245 543542 40483 62904752
Rheumatoid lung 17.22 10.28 72 543715 3776 62941459
Inappropriate antidiuretic hormone secretion 17.18 10.28 71 543716 15391 62929844
Ketoacidosis 17.14 10.28 8 543779 4370 62940865
Fracture 17.11 10.28 249 543538 19335 62925900
Sensitisation 17.08 10.28 4 543783 3382 62941853
Skin papilloma 17.06 10.28 86 543701 4883 62940352
Incorrect product administration duration 16.93 10.28 47 543740 11499 62933736
Threatened labour 16.90 10.28 28 543759 826 62944409
Device related infection 16.86 10.28 124 543663 23268 62921967
Sleep disorder due to a general medical condition 16.86 10.28 51 543736 12137 62933098
Product substitution issue 16.82 10.28 75 543712 15921 62929314
Abnormal dreams 16.81 10.28 41 543746 10475 62934760
Acute myocardial infarction 16.72 10.28 185 543602 31939 62913296
Polyhydramnios 16.66 10.28 50 543737 2221 62943014
Mucosal inflammation 16.64 10.28 292 543495 46636 62898599
Blood bilirubin increased 16.62 10.28 221 543566 36919 62908316
Acute coronary syndrome 16.56 10.28 39 543748 10087 62935148
Renal injury 16.55 10.28 35 543752 9404 62935831
Breast cancer female 16.51 10.28 60 543727 13499 62931736
Laryngospasm 16.47 10.28 3 543784 3025 62942210
Malignant melanoma 16.41 10.28 159 543628 11197 62934038
Acute chest syndrome 16.36 10.28 27 543760 794 62944441
Clear cell renal cell carcinoma 16.31 10.28 38 543749 1447 62943788
Product administered to patient of inappropriate age 16.21 10.28 4 543783 3264 62941971
Arthritis infective 16.21 10.28 103 543684 6375 62938860
Trigeminal neuralgia 16.16 10.28 5 543782 3514 62941721
Blood parathyroid hormone decreased 16.13 10.28 141 543646 9650 62935585
Hallucination, auditory 16.12 10.28 56 543731 12768 62932467
Congenital arterial malformation 16.03 10.28 17 543770 320 62944915
Eye pruritus 15.97 10.28 94 543693 18577 62926658
Atrial septal defect 15.95 10.28 108 543679 6830 62938405
Blood creatinine increased 15.94 10.28 603 543184 87241 62857994
Pulmonary hypertension 15.86 10.28 223 543564 36900 62908335
Stevens-Johnson syndrome 15.80 10.28 137 543650 24813 62920422
Human antichimeric antibody positive 15.79 10.28 41 543746 1673 62943562
Genital haemorrhage 15.72 10.28 24 543763 7308 62937927
Intracranial pressure increased 15.70 10.28 13 543774 5214 62940021
Presyncope 15.68 10.28 157 543630 27628 62917607
Anuria 15.64 10.28 55 543732 12496 62932739
Acidosis 15.54 10.28 47 543740 11186 62934049
Middle insomnia 15.36 10.28 56 543731 12587 62932648
Melaena 15.36 10.28 176 543611 30189 62915046
Osteonecrosis of jaw 15.36 10.28 210 543577 34913 62910322
Blood alkaline phosphatase increased 15.35 10.28 267 543520 42700 62902535
Multiple drug therapy 15.33 10.28 6 543781 3640 62941595
Breast feeding 15.33 10.28 27 543760 838 62944397
Haemorrhage intracranial 15.29 10.28 61 543726 13358 62931877
Hepatitis cholestatic 15.24 10.28 22 543765 6856 62938379
Bundle branch block left 15.23 10.28 23 543764 7036 62938199
Granuloma skin 15.22 10.28 124 543663 8313 62936922
Hypercholesterolaemia 15.15 10.28 262 543525 21072 62924163
Cytokine release syndrome 15.12 10.28 67 543720 14247 62930988
Glycosylated haemoglobin increased 15.01 10.28 55 543732 12343 62932892
Oedema peripheral 14.98 10.28 1408 542379 188103 62757132
Parkinsonism 14.94 10.28 43 543744 10396 62934839
Cushingoid 14.93 10.28 124 543663 8361 62936874
Gestational hypertension 14.79 10.28 50 543737 2367 62942868
Hypertransaminasaemia 14.78 10.28 21 543766 6588 62938647
Jaundice cholestatic 14.73 10.28 25 543762 7299 62937936
Infusion site pruritus 14.70 10.28 18 543769 6017 62939218
Myopathy 14.66 10.28 48 543739 11143 62934092
Graft versus host disease 14.63 10.28 22 543765 6741 62938494
Erythema 14.58 10.28 1301 542486 174450 62770785
Atrioventricular block 14.57 10.28 27 543760 7620 62937615
Hallucination, visual 14.54 10.28 101 543686 19197 62926038
Heart rate increased 14.54 10.28 659 543128 93579 62851656
Restless legs syndrome 14.46 10.28 96 543691 18435 62926800
Colitis 14.45 10.28 311 543476 48217 62897018
Exostosis 14.40 10.28 224 543563 17638 62927597
Respiratory acidosis 14.37 10.28 22 543765 6693 62938542
Acute myeloid leukaemia 14.32 10.28 87 543700 17060 62928175
Wrong product administered 14.25 10.28 19 543768 6122 62939113
Embedded device 14.21 10.28 6 543781 3477 62941758
Thrombosis 14.20 10.28 434 543353 64321 62880914
Lupus vulgaris 14.20 10.28 94 543693 5900 62939335
Aspergillus infection 14.19 10.28 30 543757 8063 62937172
Neurologic neglect syndrome 14.16 10.28 3 543784 2718 62942517
Epistaxis 14.15 10.28 495 543292 72230 62873005
Antinuclear antibody positive 14.13 10.28 117 543670 7882 62937353
Atrioventricular block complete 14.13 10.28 31 543756 8220 62937015
Eating disorder 14.10 10.28 100 543687 18916 62926319
Ageusia 14.06 10.28 65 543722 13663 62931572
Eye swelling 13.98 10.28 134 543653 23784 62921451
Hypomagnesaemia 13.98 10.28 168 543619 28569 62916666
Occult blood 13.97 10.28 33 543754 1268 62943967
Human herpesvirus 6 infection 13.95 10.28 4 543783 2953 62942282
Fear of injection 13.86 10.28 107 543680 7057 62938178
Bone lesion 13.85 10.28 18 543769 5863 62939372
Personality change 13.85 10.28 24 543763 6949 62938286
Skin toxicity 13.82 10.28 12 543775 4702 62940533
Stillbirth 13.73 10.28 102 543685 6648 62938587
Colitis microscopic 13.71 10.28 38 543749 9301 62935934
Drug abuser 13.70 10.28 4 543783 2919 62942316
Reversible cerebral vasoconstriction syndrome 13.69 10.28 3 543784 2655 62942580
Pruritus genital 13.66 10.28 3 543784 2651 62942584
Drug screen positive 13.65 10.28 7 543780 3622 62941613
Dermatitis exfoliative 13.60 10.28 16 543771 5443 62939792
Transplant dysfunction 13.57 10.28 13 543774 4859 62940376
Transaminases increased 13.55 10.28 188 543599 31179 62914056
Anti-neutrophil cytoplasmic antibody positive vasculitis 13.53 10.28 4 543783 2895 62942340
Motor dysfunction 13.52 10.28 47 543740 10714 62934521
Exomphalos 13.44 10.28 20 543767 537 62944698
Postoperative wound infection 13.43 10.28 148 543639 10777 62934458
Abortion incomplete 13.42 10.28 5 543782 3126 62942109
Premature delivery 13.38 10.28 347 543440 29934 62915301
Silent thyroiditis 13.36 10.28 9 543778 87 62945148
Blood iron increased 13.31 10.28 36 543751 1506 62943729
Acute respiratory distress syndrome 13.28 10.28 133 543654 23401 62921834
Flatulence 13.26 10.28 213 543574 34489 62910746
Rectal haemorrhage 13.25 10.28 319 543468 48711 62896524
Antibody test positive 13.19 10.28 52 543735 2655 62942580
Neutrophilia 13.18 10.28 11 543776 4395 62940840
Epstein-Barr virus infection 13.17 10.28 31 543756 8019 62937216
Electrocardiogram QRS complex prolonged 13.15 10.28 19 543768 5919 62939316
Cholinergic syndrome 13.07 10.28 19 543768 499 62944736
Gastrointestinal haemorrhage 13.06 10.28 565 543222 80611 62864624
Application site pain 13.06 10.28 10 543777 4172 62941063
Gastroenteritis viral 13.05 10.28 280 543507 23420 62921815
Fracture delayed union 13.01 10.28 48 543739 2374 62942861
Gastroschisis 12.90 10.28 17 543770 406 62944829
Acute pulmonary oedema 12.89 10.28 32 543755 8126 62937109
Blood glucose decreased 12.84 10.28 116 543671 20836 62924399
Crohn's disease 12.84 10.28 79 543708 4834 62940401
Short stature 12.83 10.28 22 543765 668 62944567
Ataxia 12.74 10.28 77 543710 15118 62930117
Scleritis 12.73 10.28 73 543714 4355 62940880
Haemoglobin decreased 12.71 10.28 1428 542359 144057 62801178
Pelvic pain 12.69 10.28 66 543721 13453 62931782
Tumour marker increased 12.69 10.28 14 543773 4901 62940334
Blood test abnormal 12.68 10.28 80 543707 15549 62929686
Bursitis 12.67 10.28 411 543376 36630 62908605
Injection site rash 12.64 10.28 229 543558 18580 62926655
Skin burning sensation 12.62 10.28 61 543726 12673 62932562
Affect lability 12.51 10.28 51 543736 11100 62934135
Extra dose administered 12.48 10.28 22 543765 6328 62938907
Haemoptysis 12.47 10.28 172 543615 28554 62916681
Post-traumatic stress disorder 12.44 10.28 16 543771 5235 62940000
Metastases to central nervous system 12.29 10.28 64 543723 13041 62932194
Hallucinations, mixed 12.20 10.28 14 543773 4815 62940420
Non-small cell lung cancer 12.19 10.28 62 543725 3533 62941702
Atrial tachycardia 12.18 10.28 11 543776 4229 62941006
Proteinuria 12.18 10.28 105 543682 19040 62926195
Increased appetite 12.14 10.28 42 543745 9588 62935647
Inadequate analgesia 12.12 10.28 5 543782 2938 62942297
Skin plaque 12.10 10.28 34 543753 8286 62936949
Malaise 12.10 10.28 3274 540513 412680 62532555
Defaecation disorder 12.09 10.28 23 543764 758 62944477
Bundle branch block right 12.08 10.28 15 543772 4983 62940252
Endophthalmitis 11.99 10.28 8 543779 3584 62941651
Lymphatic fistula 11.99 10.28 23 543764 763 62944472
Oliguria 11.94 10.28 39 543748 9062 62936173
Haemorrhage in pregnancy 11.94 10.28 40 543747 1885 62943350
Rales 11.91 10.28 62 543725 12635 62932600
Disturbance in social behaviour 11.90 10.28 10 543777 3983 62941252
Lacrimation increased 11.89 10.28 116 543671 20515 62924720
Toxic encephalopathy 11.87 10.28 24 543763 6555 62938680
Adenovirus infection 11.86 10.28 8 543779 3563 62941672
Haematemesis 11.84 10.28 186 543601 30226 62915009
Ejection fraction 11.83 10.28 3 543784 2403 62942832
Pharyngeal oedema 11.78 10.28 69 543718 13652 62931583
Hypoventilation 11.77 10.28 14 543773 4740 62940495
Speech disorder developmental 11.76 10.28 21 543766 659 62944576
Muscle contractions involuntary 11.72 10.28 3 543784 2389 62942846
Congenital cerebral cyst 11.72 10.28 13 543774 258 62944977
Joint noise 11.72 10.28 71 543716 4321 62940914
Panniculitis 11.69 10.28 149 543638 11236 62933999
Oligoarthritis 11.68 10.28 19 543768 552 62944683
Hepatic function abnormal 11.65 10.28 408 543379 36734 62908501
Herpes zoster 11.60 10.28 838 542949 81624 62863611
Drug eruption 11.59 10.28 325 543462 28369 62916866
Rash macular 11.59 10.28 136 543651 23228 62922007
Hypertelorism 11.57 10.28 17 543770 451 62944784
Troponin increased 11.54 10.28 46 543741 10075 62935160
Ankle arthroplasty 11.54 10.28 38 543749 1775 62943460
Autism spectrum disorder 11.52 10.28 24 543763 846 62944389
Nephropathy toxic 11.51 10.28 42 543745 9437 62935798
Ulcer 11.49 10.28 299 543488 25808 62919427
Pruritus 11.47 10.28 2834 540953 358619 62586616
Wound infection pseudomonas 11.46 10.28 31 543756 1297 62943938
Tubulointerstitial nephritis 11.43 10.28 112 543675 19791 62925444
Talipes 11.39 10.28 34 543753 1506 62943729
Hepatitis acute 11.34 10.28 40 543747 9080 62936155
Coronary arterial stent insertion 11.34 10.28 5 543782 2824 62942411
Bronchopulmonary aspergillosis 11.33 10.28 37 543750 8598 62936637
Foetal distress syndrome 11.31 10.28 31 543756 1307 62943928
Stoma site pruritus 11.31 10.28 3 543784 0 62945235
Cardiac monitoring abnormal 11.31 10.28 3 543784 0 62945235
X-ray gastrointestinal tract abnormal 11.31 10.28 3 543784 0 62945235
Corneal opacity congenital 11.31 10.28 3 543784 0 62945235
Renal mass 11.30 10.28 45 543742 2308 62942927
Vascular device infection 11.30 10.28 29 543758 7283 62937952
Oxygen consumption increased 11.25 10.28 10 543777 3874 62941361
Blood pressure decreased 11.22 10.28 449 543338 64573 62880662
Illness 11.20 10.28 327 543460 48732 62896503
White blood cell count decreased 11.20 10.28 1032 542755 138072 62807163
Induced labour 11.18 10.28 25 543762 926 62944309
Injection site bruising 11.14 10.28 452 543335 41458 62903777
Upper respiratory tract inflammation 11.13 10.28 47 543740 2476 62942759
Therapy change 11.13 10.28 22 543765 6059 62939176
Acute graft versus host disease in skin 11.11 10.28 8 543779 3444 62941791
Poor quality sleep 11.10 10.28 113 543674 19822 62925413
Hepatic cirrhosis 11.10 10.28 284 543503 24450 62920785
Full blood count abnormal 11.04 10.28 198 543589 31519 62913716
Dactylitis 11.02 10.28 48 543739 2564 62942671
Cholestasis of pregnancy 10.98 10.28 29 543758 1196 62944039
Soft tissue disorder 10.97 10.28 13 543774 4409 62940826
Haemodynamic instability 10.97 10.28 41 543746 9149 62936086
Hyperpyrexia 10.95 10.28 9 543778 3623 62941612
Nail injury 10.95 10.28 20 543767 639 62944596
Plasma cell myeloma recurrent 10.94 10.28 7 543780 3206 62942029
Femoral hernia incarcerated 10.91 10.28 23 543764 818 62944417
Human anti-human antibody test 10.90 10.28 16 543771 424 62944811
Device malfunction 10.89 10.28 99 543688 17758 62927477
Catheter management 10.88 10.28 6 543781 2981 62942254
Hyperthermia 10.83 10.28 41 543746 9115 62936120
Nasal obstruction 10.76 10.28 36 543751 1695 62943540
Metabolic disorder 10.67 10.28 25 543762 6478 62938757
Amnesia 10.66 10.28 379 543408 55206 62890029
Ear pain 10.60 10.28 232 543555 35886 62909349
Treatment noncompliance 10.60 10.28 241 543546 37084 62908151
Cervical incompetence 10.60 10.28 19 543768 598 62944637
Heat illness 10.59 10.28 11 543776 202 62945033
Lymphopenia 10.58 10.28 103 543684 18224 62927011
Breast cancer metastatic 10.55 10.28 60 543727 11958 62933277
Incoherent 10.53 10.28 14 543773 4516 62940719
Pyelonephritis acute 10.52 10.28 72 543715 4569 62940666
Myocarditis 10.50 10.28 49 543738 10276 62934959
Red blood cell count decreased 10.49 10.28 437 543350 40208 62905027
Cartilage injury 10.47 10.28 39 543748 1938 62943297
Hepatitis B reactivation 10.45 10.28 7 543780 3130 62942105
Dysuria 10.40 10.28 215 543572 33523 62911712
Learning disorder 10.40 10.28 20 543767 665 62944570
Intervertebral disc degeneration 10.39 10.28 191 543596 15541 62929694
Klebsiella infection 10.37 10.28 38 543749 8528 62936707
Pericardial effusion 10.35 10.28 188 543599 29870 62915365
Sleep terror 10.33 10.28 5 543782 2675 62942560
Incorrect route of product administration 10.32 10.28 169 543618 27283 62917952
Abortion threatened 10.32 10.28 18 543769 554 62944681
Rash morbilliform 10.32 10.28 8 543779 3317 62941918
Pain in extremity 10.32 10.28 3084 540703 328402 62616833
Forceps delivery 10.29 10.28 11 543776 209 62945026
Oral pain 10.29 10.28 176 543611 28218 62917017

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 480.05 10.27 829 204170 37409 34714523
Drug abuse 437.50 10.27 39 204960 99057 34652875
Toxicity to various agents 386.04 10.27 364 204635 199998 34551934
Completed suicide 310.09 10.27 95 204904 98073 34653859
Foetal exposure during pregnancy 228.46 10.27 612 204387 37489 34714443
Drug interaction 189.09 10.27 685 204314 225261 34526671
Arthralgia 155.07 10.27 1601 203398 168440 34583492
Psoriatic arthropathy 151.35 10.27 349 204650 19449 34732483
Interstitial lung disease 145.70 10.27 762 204237 64520 34687412
Sickle cell anaemia with crisis 133.84 10.27 141 204858 3912 34748020
Dysmorphism 117.28 10.27 117 204882 3039 34748893
Intentional overdose 110.60 10.27 59 204940 43615 34708317
Product use in unapproved indication 99.56 10.27 354 204645 117145 34634787
Overdose 88.51 10.27 258 204741 90801 34661131
Acute kidney injury 88.22 10.27 1259 203740 303729 34448203
Death 83.91 10.27 1740 203259 396309 34355623
Joint swelling 83.18 10.27 619 204380 59271 34692661
Drug reaction with eosinophilia and systemic symptoms 74.61 10.27 51 204948 32961 34718971
Premature baby 74.47 10.27 269 204730 19364 34732568
Enthesopathy 72.78 10.27 111 204888 4502 34747430
Coma 72.41 10.27 97 204902 45581 34706351
C-reactive protein increased 68.91 10.27 548 204451 53550 34698382
Musculoskeletal stiffness 67.98 10.27 488 204511 46192 34705740
Tenosynovitis 67.95 10.27 107 204892 4463 34747469
Drug dependence 66.98 10.27 29 204970 24188 34727744
Synovitis 66.90 10.27 208 204791 13858 34738074
Blood pressure fluctuation 64.99 10.27 307 204692 24942 34726990
Speech disorder developmental 64.70 10.27 72 204927 2128 34749804
Platelet count decreased 62.94 10.27 1019 203980 118698 34633234
Drug resistance 62.79 10.27 37 204962 25890 34726042
Exposure during pregnancy 62.32 10.27 152 204847 8782 34743150
Suicide attempt 62.07 10.27 83 204916 39033 34712899
Suicidal ideation 59.82 10.27 90 204909 40298 34711634
C-reactive protein abnormal 58.44 10.27 146 204853 8564 34743368
Angioedema 56.60 10.27 82 204917 37292 34714640
Psoriasis 56.07 10.27 405 204594 38407 34713525
Foetal anticonvulsant syndrome 55.55 10.27 50 204949 1137 34750795
Drug ineffective 55.11 10.27 2157 202842 454594 34297338
Neonatal respiratory distress syndrome 53.92 10.27 90 204909 3944 34747988
Pneumonia 53.45 10.27 2618 202381 360009 34391923
Maternal exposure during pregnancy 51.95 10.27 99 204900 4819 34747113
Alanine aminotransferase abnormal 51.55 10.27 96 204903 4592 34747340
Psychotic disorder 49.85 10.27 42 204957 24410 34727522
Hypospadias 49.06 10.27 76 204923 3125 34748807
Atrial septal defect 48.64 10.27 123 204876 7269 34744663
Low birth weight baby 48.38 10.27 128 204871 7777 34744155
Hypermagnesaemia 47.00 10.27 25 204974 229 34751703
Nasopharyngitis 45.94 10.27 619 204380 69349 34682583
Off label use 45.50 10.27 2005 202994 417519 34334413
Learning disorder 45.33 10.27 43 204956 1048 34750884
Autism spectrum disorder 44.63 10.27 61 204938 2235 34749697
Cryptorchism 43.94 10.27 57 204942 1984 34749948
Blood pressure systolic increased 43.86 10.27 257 204742 22695 34729237
Lactic acidosis 43.70 10.27 86 204913 34686 34717246
Maternal drugs affecting foetus 43.35 10.27 81 204918 3884 34748048
Arthropathy 42.52 10.27 287 204712 26620 34725312
Intentional product misuse 42.30 10.27 132 204867 45479 34706453
Hepatic function abnormal 41.39 10.27 420 204579 43943 34707989
Arthritis 41.26 10.27 320 204679 31026 34720906
Maternal exposure during breast feeding 41.20 10.27 48 204951 1493 34750439
Hypoglycaemia neonatal 40.78 10.27 53 204946 1848 34750084
Drug withdrawal syndrome 40.51 10.27 34 204965 19800 34732132
Sedation 40.51 10.27 38 204961 20968 34730964
Haemoglobin decreased 40.38 10.27 960 204039 119812 34632120
Poisoning 40.09 10.27 11 204988 12215 34739717
Neutrophil count decreased 39.91 10.27 467 204532 50637 34701295
Pancytopenia 39.02 10.27 779 204220 94378 34657554
Small for dates baby 38.98 10.27 77 204922 3850 34748082
Lung neoplasm malignant 38.73 10.27 203 204796 17192 34734740
Serotonin syndrome 38.51 10.27 36 204963 19897 34732035
Tongue disorder 38.48 10.27 92 204907 5247 34746685
Rheumatoid nodule 38.39 10.27 65 204934 2882 34749050
Pulmonary fibrosis 37.78 10.27 210 204789 18186 34733746
Non-small cell lung cancer 37.60 10.27 76 204923 3864 34748068
Blood pressure systolic abnormal 37.50 10.27 76 204923 3872 34748060
Pain 37.37 10.27 1511 203488 203164 34548768
Rhabdomyolysis 37.36 10.27 240 204759 67923 34684009
Syndactyly 37.23 10.27 35 204964 843 34751089
Pathogen resistance 36.25 10.27 6 204993 9476 34742456
Agitation 35.75 10.27 194 204805 57205 34694727
Urticaria 35.54 10.27 217 204782 62160 34689772
Bradycardia 35.26 10.27 278 204721 75140 34676792
Blood pressure diastolic decreased 34.82 10.27 125 204874 8969 34742963
Ventricular septal defect 34.47 10.27 74 204925 3927 34748005
Renal failure 33.81 10.27 550 204449 130007 34621925
Respiratory arrest 33.01 10.27 72 204927 27971 34723961
Disease progression 32.95 10.27 441 204558 107636 34644296
Infusion related reaction 32.63 10.27 464 204535 52593 34699339
Blood pressure diastolic abnormal 32.57 10.27 81 204918 4737 34747195
Foot deformity 32.51 10.27 78 204921 4459 34747473
Hand deformity 32.21 10.27 69 204930 3656 34748276
Developmental delay 31.99 10.27 58 204941 2717 34749215
Confusional state 31.73 10.27 625 204374 143535 34608397
Joint laxity 31.24 10.27 23 204976 389 34751543
Exposure via breast milk 31.19 10.27 48 204951 1962 34749970
Joint effusion 30.68 10.27 83 204916 5110 34746822
Acute hepatic failure 30.16 10.27 23 204976 14051 34737881
Osteoarthritis 30.15 10.27 216 204783 20426 34731506
Grip strength decreased 30.09 10.27 61 204938 3108 34748824
Talipes 29.95 10.27 46 204953 1877 34750055
Drug ineffective for unapproved indication 29.50 10.27 59 204940 23656 34728276
Cardiac arrest 29.44 10.27 392 204607 95767 34656165
Substance abuse 28.85 10.27 5 204994 7636 34744296
Jaundice neonatal 28.06 10.27 37 204962 1309 34750623
Congenital hand malformation 27.72 10.27 25 204974 570 34751362
Toxic epidermal necrolysis 27.66 10.27 53 204946 21593 34730339
Aggression 27.52 10.27 126 204873 38838 34713094
Serum ferritin increased 27.50 10.27 89 204910 6057 34745875
Plagiocephaly 27.47 10.27 24 204975 524 34751408
Hypermobility syndrome 26.84 10.27 20 204979 345 34751587
Haematocrit decreased 26.77 10.27 298 204701 31918 34720014
Immune reconstitution inflammatory syndrome 26.69 10.27 9 204990 8750 34743182
Intentional self-injury 26.45 10.27 25 204974 13746 34738186
Tendonitis 26.40 10.27 115 204884 9025 34742907
Heart rate decreased 26.08 10.27 293 204706 31452 34720480
Tachycardia 25.43 10.27 347 204652 84425 34667507
Intellectual disability 25.18 10.27 35 204964 1303 34750629
White blood cell count decreased 24.76 10.27 734 204265 94711 34657221
Finger deformity 24.71 10.27 37 204962 1476 34750456
Somnolence 24.66 10.27 481 204518 110635 34641297
Infective pulmonary exacerbation of cystic fibrosis 24.50 10.27 5 204994 6796 34745136
Basal cell carcinoma 24.40 10.27 198 204801 19460 34732472
Polyarthritis 24.30 10.27 70 204929 4470 34747462
Cholestasis 24.27 10.27 79 204920 26869 34725063
Acute chest syndrome 24.21 10.27 27 204972 800 34751132
Cerebral infarction 23.75 10.27 256 204743 27199 34724733
Caesarean section 23.40 10.27 44 204955 2120 34749812
Language disorder 23.32 10.27 45 204954 2211 34749721
Knee arthroplasty 23.31 10.27 96 204903 7348 34744584
Multiple organ dysfunction syndrome 23.11 10.27 313 204686 76253 34675679
Blood lactate dehydrogenase increased 23.06 10.27 221 204778 22769 34729163
Dysgraphia 22.89 10.27 45 204954 2242 34749690
Red blood cell count decreased 22.78 10.27 266 204733 28824 34723108
Astigmatism 22.63 10.27 30 204969 1067 34750865
Depression 22.57 10.27 417 204582 96681 34655251
Liver disorder 22.50 10.27 294 204705 32703 34719229
Metabolic acidosis 22.32 10.27 157 204842 43523 34708409
No adverse event 22.22 10.27 65 204934 22862 34729070
Anal fistula 22.21 10.27 76 204923 5323 34746609
Pneumonia aspiration 22.10 10.27 357 204642 41546 34710386
Diaphragmatic disorder 22.00 10.27 32 204967 1243 34750689
Large for dates baby 21.92 10.27 27 204972 891 34751041
Red blood cell sedimentation rate increased 21.84 10.27 109 204890 9053 34742879
Pain in extremity 21.68 10.27 928 204071 125585 34626347
Foetal growth restriction 21.57 10.27 63 204936 4054 34747878
Hydrops foetalis 21.52 10.27 26 204973 841 34751091
Ultrasound antenatal screen 21.38 10.27 21 204978 535 34751397
Blood pressure increased 21.37 10.27 672 204327 87430 34664502
Hydrocele 20.81 10.27 41 204958 2046 34749886
Hypotonia neonatal 20.70 10.27 32 204967 1313 34750619
Radiation pneumonitis 20.68 10.27 47 204952 2593 34749339
Diabetic ketoacidosis 20.64 10.27 47 204952 17985 34733947
Hyperbilirubinaemia neonatal 20.31 10.27 24 204975 758 34751174
Selective eating disorder 20.29 10.27 37 204962 1741 34750191
Hepatocellular injury 20.08 10.27 65 204934 22146 34729786
Drug intolerance 20.03 10.27 474 204525 59096 34692836
Gastrointestinal infection 19.95 10.27 77 204922 5721 34746211
Knee deformity 19.88 10.27 22 204977 646 34751286
Motor developmental delay 19.88 10.27 22 204977 646 34751286
Product quality issue 19.83 10.27 44 204955 16991 34734941
Irritability 19.82 10.27 76 204923 24614 34727318
Inflammation 19.67 10.27 253 204746 28042 34723890
Dyspraxia 19.65 10.27 18 204981 419 34751513
Lower respiratory tract infection 19.57 10.27 277 204722 31360 34720572
Muscle twitching 19.42 10.27 19 204980 10279 34741653
Cancer pain 19.21 10.27 46 204953 2626 34749306
Hallucination 19.19 10.27 201 204798 51297 34700635
Blood pressure diastolic increased 19.18 10.27 69 204930 4956 34746976
Radiation inflammation 19.05 10.27 25 204974 880 34751052
Trisomy 18 18.94 10.27 23 204976 748 34751184
Electrocardiogram QRS complex prolonged 18.93 10.27 3 204996 4891 34747041
Respiratory depression 18.88 10.27 42 204957 16203 34735729
Drug withdrawal syndrome neonatal 18.60 10.27 55 204944 3564 34748368
Wound 18.60 10.27 150 204849 14714 34737218
Strabismus 18.47 10.27 35 204964 1696 34750236
Unresponsive to stimuli 18.39 10.27 91 204908 27478 34724454
Sexual dysfunction 18.32 10.27 7 204992 6296 34745636
Upper respiratory tract inflammation 18.29 10.27 35 204964 1709 34750223
Body temperature decreased 18.24 10.27 135 204864 12899 34739033
Nasal disorder 18.17 10.27 37 204962 1891 34750041
Myalgia 18.08 10.27 366 204633 83744 34668188
Otitis media 18.08 10.27 47 204952 2825 34749107
Hypotension 18.04 10.27 1090 203909 220559 34531373
Hyperhidrosis 17.92 10.27 324 204675 75368 34676564
Post transplant lymphoproliferative disorder 17.76 10.27 8 204991 6520 34745412
Foetal disorder 17.67 10.27 23 204976 803 34751129
Congenital foot malformation 17.57 10.27 17 204982 425 34751507
Peripheral swelling 17.57 10.27 580 204419 75961 34675971
Dyslexia 17.50 10.27 15 204984 319 34751613
Cleft lip and palate 17.38 10.27 24 204975 888 34751044
Ankylosing spondylitis 17.34 10.27 72 204927 5532 34746400
Disseminated intravascular coagulation 17.31 10.27 200 204799 21616 34730316
Withdrawal syndrome 17.26 10.27 29 204970 12426 34739506
Rash maculo-papular 17.25 10.27 97 204902 28354 34723578
Limb reduction defect 17.17 10.27 14 204985 277 34751655
Neurotoxicity 16.78 10.27 52 204947 17958 34733974
Vitamin D deficiency 16.74 10.27 80 204919 6528 34745404
Adenovirus infection 16.74 10.27 5 204994 5252 34746680
Infection 16.73 10.27 672 204327 90243 34661689
Neuroleptic malignant syndrome 16.55 10.27 52 204947 17882 34734050
Red blood cell sedimentation rate 16.54 10.27 27 204972 1161 34750771
Anal fissure 16.45 10.27 59 204940 4231 34747701
Progressive multifocal leukoencephalopathy 16.23 10.27 20 204979 9744 34742188
Respiratory disorder neonatal 16.23 10.27 32 204967 1598 34750334
Wrong technique in product usage process 16.19 10.27 134 204865 35852 34716080
Localised infection 16.15 10.27 166 204833 17421 34734511
Medical device implantation 15.91 10.27 19 204980 607 34751325
Paranoia 15.90 10.27 29 204970 12039 34739893
Blood parathyroid hormone decreased 15.89 10.27 30 204969 1450 34750482
Multiple congenital abnormalities 15.80 10.27 18 204981 546 34751386
Skin cancer 15.77 10.27 109 204890 10188 34741744
Immunodeficiency 15.74 10.27 69 204930 5429 34746503
Malignant melanoma 15.72 10.27 91 204908 7999 34743933
Tuberculosis 15.71 10.27 95 204904 8482 34743450
Crohn's disease 15.67 10.27 47 204952 3070 34748862
Therapy partial responder 15.66 10.27 20 204979 9596 34742336
Cellulitis 15.62 10.27 414 204585 52537 34699395
Nodule 15.47 10.27 80 204919 6739 34745193
Lacrimal disorder 15.42 10.27 14 204985 322 34751610
Congenital bladder anomaly 15.42 10.27 13 204986 270 34751662
Cleft lip 15.39 10.27 14 204985 323 34751609
Agitation neonatal 15.39 10.27 25 204974 1071 34750861
Cytomegalovirus infection 15.36 10.27 90 204909 26045 34725887
Arthritis bacterial 15.33 10.27 65 204934 5041 34746891
Weight decrease neonatal 15.32 10.27 14 204985 325 34751607
Lip swelling 15.28 10.27 46 204953 16034 34735898
Juvenile idiopathic arthritis 15.11 10.27 34 204965 1863 34750069
Granuloma skin 15.09 10.27 27 204972 1252 34750680
Loss of personal independence in daily activities 15.08 10.27 276 204723 32903 34719029
Pectus excavatum 15.04 10.27 12 204987 230 34751702
Microcephaly 14.94 10.27 21 204978 790 34751142
Inguinal hernia 14.88 10.27 86 204913 7555 34744377
Ankyloglossia congenital 14.87 10.27 13 204986 284 34751648
Obsessive-compulsive disorder 14.86 10.27 7 204992 5557 34746375
Poor venous access 14.81 10.27 65 204934 5118 34746814
Pruritus 14.79 10.27 681 204318 141300 34610632
Coronary artery disease 14.74 10.27 197 204802 48108 34703824
Renal injury 14.67 10.27 27 204972 11168 34740764
Blood albumin decreased 14.38 10.27 132 204867 13440 34738492
Skin injury 14.38 10.27 38 204961 2307 34749625
Renal aplasia 14.36 10.27 20 204979 746 34751186
Iron overload 14.29 10.27 27 204972 1306 34750626
Suspected suicide 14.26 10.27 5 204994 4743 34747189
Lymphangiosis carcinomatosa 14.10 10.27 22 204977 910 34751022
Joint range of motion decreased 14.05 10.27 82 204917 7230 34744702
Agranulocytosis 14.02 10.27 82 204917 23739 34728193
Haemangioma 14.01 10.27 33 204966 1864 34750068
Panniculitis 13.98 10.27 34 204965 1960 34749972
Aspergillus infection 13.98 10.27 32 204967 12222 34739710
Arthritis infective 13.95 10.27 48 204951 3371 34748561
Scoliosis 13.93 10.27 42 204957 2751 34749181
Device leakage 13.76 10.27 11 204988 6564 34745368
Cardiotoxicity 13.76 10.27 8 204991 5640 34746292
Potentiating drug interaction 13.70 10.27 6 204993 4971 34746961
Colon cancer 13.64 10.27 92 204907 8529 34743403
Haemangioma congenital 13.62 10.27 16 204983 502 34751430
Joint ankylosis 13.46 10.27 29 204970 1543 34750389
Congenital anomaly 13.45 10.27 27 204972 1366 34750566
Spinal disorder 13.45 10.27 55 204944 4197 34747735
Oxygen saturation decreased 13.44 10.27 412 204587 53406 34698526
Arthrodesis 13.38 10.27 15 204984 447 34751485
Oropharyngeal pain 13.38 10.27 287 204712 35198 34716734
Abortion spontaneous 13.36 10.27 14 204985 386 34751546
Second primary malignancy 13.27 10.27 16 204983 7870 34744062
Erectile dysfunction 13.26 10.27 69 204930 20568 34731364
Oesophageal fibrosis 13.25 10.27 10 204989 176 34751756
Electrocardiogram QT prolonged 13.24 10.27 165 204834 40787 34711145
Myocardial infarction 13.17 10.27 578 204421 120507 34631425
Spinal compression fracture 13.15 10.27 79 204920 7037 34744895
Vision blurred 13.11 10.27 190 204809 45773 34706159
Akathisia 13.07 10.27 17 204982 8092 34743840
Enteritis infectious 13.05 10.27 26 204973 1308 34750624
Tooth malformation 13.01 10.27 10 204989 181 34751751
Neck mass 12.95 10.27 29 204970 1584 34750348
Vascular insufficiency 12.93 10.27 13 204986 341 34751591
Arnold-Chiari malformation 12.93 10.27 13 204986 341 34751591
Musculoskeletal pain 12.86 10.27 261 204738 31702 34720230
C-reactive protein decreased 12.85 10.27 33 204966 1969 34749963
Hepatic failure 12.77 10.27 135 204864 34396 34717536
Meningeal disorder 12.77 10.27 13 204986 346 34751586
Blood insulin increased 12.74 10.27 13 204986 347 34751585
Decreased appetite 12.70 10.27 1137 203862 165255 34586677
Aspartate aminotransferase increased 12.70 10.27 502 204497 67281 34684651
Joint stiffness 12.68 10.27 108 204891 10765 34741167
Latent tuberculosis 12.66 10.27 26 204973 1337 34750595
Exposure to toxic agent 12.64 10.27 3 204996 3672 34748260
Squamous cell carcinoma of lung 12.59 10.27 32 204967 1897 34750035
Hyperthermia 12.57 10.27 27 204972 10550 34741382
Developmental coordination disorder 12.56 10.27 10 204989 191 34751741
Venoocclusive liver disease 12.53 10.27 17 204982 7949 34743983
Anti-cyclic citrullinated peptide antibody positive 12.47 10.27 31 204968 1812 34750120
Colitis ulcerative 12.46 10.27 150 204849 16370 34735562
Bronchiolitis 12.45 10.27 44 204955 3132 34748800
Pleural fibrosis 12.44 10.27 26 204973 1354 34750578
Maternal exposure before pregnancy 12.43 10.27 19 204980 772 34751160
Fistula discharge 12.41 10.27 20 204979 851 34751081
Synovial cyst 12.41 10.27 36 204963 2308 34749624
Paraesthesia 12.41 10.27 284 204715 63888 34688044
Autoscopy 12.37 10.27 11 204988 246 34751686
Attention deficit hyperactivity disorder 12.31 10.27 38 204961 2521 34749411
Polydactyly 12.30 10.27 24 204975 1189 34750743
Anxiety 12.22 10.27 468 204531 98960 34652972
Anaphylactic shock 12.20 10.27 50 204949 15891 34736041
Nocardiosis 12.15 10.27 4 204995 3947 34747985
Hypertelorism 12.13 10.27 16 204983 566 34751366
Dysstasia 12.12 10.27 117 204882 12078 34739854
Maternal exposure timing unspecified 12.07 10.27 13 204986 370 34751562
Ear disorder 12.05 10.27 29 204970 1661 34750271
Septic arthritis staphylococcal 12.04 10.27 15 204984 501 34751431
Bradycardia neonatal 12.02 10.27 21 204978 955 34750977
Hepatitis E antibody positive 12.01 10.27 11 204988 256 34751676
Weight decreased 12.01 10.27 1195 203804 175106 34576826
Blood test abnormal 12.01 10.27 76 204923 6895 34745037
Bone cyst 12.00 10.27 28 204971 1572 34750360
Adverse drug reaction 11.99 10.27 112 204887 29230 34722702
Nephropathy toxic 11.97 10.27 36 204963 12552 34739380
Foetal heart rate deceleration abnormality 11.92 10.27 15 204984 506 34751426
Pulmonary toxicity 11.85 10.27 69 204930 6078 34745854
Mechanical ileus 11.82 10.27 13 204986 379 34751553
Endophthalmitis 11.80 10.27 3 204996 3505 34748427
Pulmonary vasculitis 11.77 10.27 16 204983 583 34751349
Pleural effusion 11.77 10.27 588 204411 80958 34670974
Post procedural infection 11.74 10.27 58 204941 4798 34747134
Hepatitis 11.69 10.27 87 204912 23817 34728115
Ileus 11.67 10.27 148 204851 16351 34735581
Gross motor delay 11.65 10.27 12 204987 324 34751608
Eosinophilia 11.63 10.27 98 204901 26124 34725808
Drug use disorder 11.62 10.27 5 204994 4186 34747746
Vitamin B complex deficiency 11.55 10.27 13 204986 389 34751543
Malignant neoplasm progression 11.52 10.27 629 204370 87417 34664515
Alanine aminotransferase increased 11.51 10.27 582 204417 80233 34671699
Foetal distress syndrome 11.44 10.27 22 204977 1078 34750854
Extrapyramidal disorder 11.43 10.27 38 204961 12842 34739090
Haematotoxicity 11.43 10.27 19 204980 8175 34743757
Behaviour disorder 11.41 10.27 58 204941 4852 34747080
Umbilical hernia 11.40 10.27 56 204943 4621 34747311
Respiratory rate increased 11.39 10.27 98 204901 9796 34742136
Fracture 11.39 10.27 74 204925 6775 34745157
Bulbospinal muscular atrophy congenital 11.36 10.27 4 204995 11 34751921
Peripheral artery thrombosis 11.31 10.27 35 204964 2325 34749607
Reticulocyte count decreased 11.30 10.27 17 204982 681 34751251
Rheumatoid lung 11.26 10.27 20 204979 922 34751010
Syringe issue 11.21 10.27 10 204989 5654 34746278
Dyspnoea 11.20 10.27 1992 203007 374790 34377142
Back disorder 11.14 10.27 72 204927 6579 34745353
Hernia pain 11.14 10.27 11 204988 282 34751650
Patent ductus arteriosus 11.10 10.27 44 204955 3310 34748622
Muscle spasms 11.07 10.27 345 204654 74656 34677276
Educational problem 11.03 10.27 15 204984 547 34751385
Anal atresia 10.98 10.27 11 204988 287 34751645
Hypertransaminasaemia 10.98 10.27 10 204989 5596 34746336
Hepatitis E virus test positive 10.95 10.27 11 204988 288 34751644
Congestive cardiomyopathy 10.86 10.27 17 204982 7493 34744439
Graft versus host disease in gastrointestinal tract 10.85 10.27 4 204995 3679 34748253
Mydriasis 10.83 10.27 16 204983 7221 34744711
Folate deficiency 10.83 10.27 23 204976 1211 34750721
Small cell lung cancer 10.81 10.27 30 204969 1875 34750057
Spina bifida 10.72 10.27 12 204987 357 34751575
Infected dermal cyst 10.71 10.27 19 204980 875 34751057
Aplasia pure red cell 10.66 10.27 67 204932 6065 34745867
Rebound effect 10.63 10.27 3 204996 3271 34748661
Accidental exposure to product 10.54 10.27 39 204960 12763 34739169
Ear malformation 10.53 10.27 11 204988 302 34751630
Hypermetropia 10.51 10.27 14 204985 500 34751432
Nail pitting 10.47 10.27 11 204988 304 34751628
Gangrene neonatal 10.47 10.27 9 204990 192 34751740
Blood magnesium decreased 10.44 10.27 69 204930 6354 34745578
Palindromic rheumatism 10.44 10.27 9 204990 193 34751739
Pneumonia bacterial 10.40 10.27 111 204888 11761 34740171
Disinhibition 10.39 10.27 3 204996 3223 34748709
Vitamin B12 deficiency 10.36 10.27 49 204950 3982 34747950
Nail bed bleeding 10.36 10.27 12 204987 371 34751561
Abnormal behaviour 10.33 10.27 95 204904 24874 34727058
Forced expiratory volume decreased 10.28 10.27 3 204996 3200 34748732

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1148.53 9.92 198 577066 245569 78921555
Toxicity to various agents 1132.16 9.92 840 576424 420700 78746424
Rheumatoid arthritis 1080.61 9.92 3643 573621 204827 78962297
Pemphigus 863.64 9.92 2096 575168 97486 79069638
Systemic lupus erythematosus 860.08 9.92 2365 574899 118784 79048340
Arthropathy 844.42 9.92 3011 574253 174100 78993024
Hand deformity 834.55 9.92 2124 575140 101795 79065329
Drug abuse 827.18 9.92 102 577162 162589 79004535
Synovitis 808.96 9.92 2666 574598 148068 79019056
Joint swelling 764.15 9.92 4111 573153 284535 78882589
Glossodynia 747.07 9.92 2031 575233 101306 79065818
Anti-cyclic citrullinated peptide antibody positive 639.21 9.92 1672 575592 81471 79085653
Wound 618.81 9.92 2050 575214 114129 79052995
Infusion related reaction 604.12 9.92 3272 573992 226965 78940159
Maternal exposure during pregnancy 599.74 9.92 2261 575003 134277 79032847
Arthralgia 584.80 9.92 6516 570748 565287 78601837
Pericarditis 571.90 9.92 1858 575406 102378 79064746
Drug interaction 538.94 9.92 1399 575865 413784 78753340
Abdominal discomfort 473.68 9.92 3273 573991 247454 78919670
Discomfort 438.74 9.92 1938 575326 123679 79043445
Alopecia 423.36 9.92 2997 574267 228358 78938766
Intentional overdose 421.10 9.92 122 577142 105838 79061286
Therapeutic product effect decreased 420.92 9.92 2316 574948 161547 79005577
Swelling 418.15 9.92 2844 574420 213867 78953257
Duodenal ulcer perforation 402.41 9.92 1223 576041 64988 79102136
Helicobacter infection 398.15 9.92 1260 576004 68444 79098680
Rheumatoid factor positive 395.76 9.92 1139 576125 58700 79108424
Contraindicated product administered 394.88 9.92 2212 575052 155326 79011798
Pain 387.14 9.92 7195 570069 696607 78470517
Death 375.90 9.92 2480 574784 564034 78603090
Musculoskeletal stiffness 358.18 9.92 2331 574933 172677 78994447
Nasopharyngitis 345.89 9.92 3073 574191 250808 78916316
Hepatic enzyme increased 328.93 9.92 2357 574907 180253 78986871
Drug intolerance 323.09 9.92 3124 574140 260995 78906129
Psoriatic arthropathy 314.04 9.92 1257 576007 76742 79090382
Acute kidney injury 289.10 9.92 2389 574875 517015 78650109
Exposure during pregnancy 268.72 9.92 1443 575821 99689 79067435
Overdose 260.40 9.92 593 576671 183613 78983511
Impaired healing 248.91 9.92 1274 575990 86381 79080743
Suicide attempt 226.30 9.92 162 577102 82770 79084354
Cardiac arrest 225.84 9.92 576 576688 171520 78995604
C-reactive protein abnormal 218.85 9.92 809 576455 47558 79119566
Muscle injury 218.69 9.92 811 576453 47750 79119374
Folliculitis 216.13 9.92 884 576380 54496 79112628
Irritable bowel syndrome 203.51 9.92 942 576322 61299 79105825
Sickle cell anaemia with crisis 199.53 9.92 266 576998 7656 79159468
Treatment failure 199.23 9.92 1998 575266 168488 78998636
Red blood cell sedimentation rate abnormal 195.35 9.92 454 576810 20509 79146615
Drug reaction with eosinophilia and systemic symptoms 195.14 9.92 111 577153 64133 79102991
Sleep disorder due to general medical condition, insomnia type 189.97 9.92 720 576544 42836 79124288
Hypersensitivity 187.63 9.92 2801 574463 259438 78907686
Product use issue 187.30 9.92 2332 574932 207490 78959634
Sedation 186.46 9.92 71 577193 51824 79115300
Lower respiratory tract infection 185.58 9.92 1583 575681 127637 79039487
Blister 184.06 9.92 1487 575777 117989 79049135
Lactic acidosis 181.02 9.92 146 577118 70213 79096911
Knee arthroplasty 177.26 9.92 701 576563 42547 79124577
Bradycardia 176.06 9.92 456 576808 135101 79032023
Sopor 174.45 9.92 18 577246 32992 79134132
Arthritis 172.22 9.92 1421 575843 113459 79053665
Peripheral swelling 169.46 9.92 2818 574446 266799 78900325
Sinusitis 169.00 9.92 2160 575104 193341 78973783
C-reactive protein increased 167.42 9.92 1546 575718 127481 79039643
Hip arthroplasty 159.19 9.92 595 576669 35161 79131963
Blood pressure fluctuation 157.72 9.92 927 576337 66218 79100906
Osteoarthritis 152.47 9.92 1119 576145 86190 79080934
Coma 152.13 9.92 312 576952 100337 79066787
Hypotension 151.42 9.92 2259 575005 438058 78729066
Drug resistance 149.59 9.92 59 577205 42154 79124970
Respiratory arrest 144.85 9.92 122 577142 57428 79109696
Renal failure 144.07 9.92 858 576406 200110 78967014
Rheumatic fever 143.47 9.92 494 576770 28031 79139093
Drug dependence 141.19 9.92 59 577205 40710 79126414
Weight increased 134.53 9.92 2785 574479 274601 78892523
Agitation 134.46 9.92 329 576935 99386 79067738
Stomatitis 129.99 9.92 1629 575635 145128 79021996
Infection 129.32 9.92 2463 574801 239249 78927875
Disease progression 125.42 9.92 800 576464 183562 78983562
Hyperhidrosis 123.83 9.92 619 576645 150873 79016251
Serotonin syndrome 122.77 9.92 88 577176 44939 79122185
Red blood cell sedimentation rate increased 120.93 9.92 654 576610 45288 79121836
Blood pressure systolic abnormal 120.54 9.92 335 576929 16912 79150212
Swollen joint count increased 120.54 9.92 403 576861 22524 79144600
Fibromyalgia 120.08 9.92 838 576426 63502 79103622
Angioedema 119.81 9.92 230 577034 75805 79091319
Blood pressure diastolic abnormal 119.73 9.92 358 576906 18844 79148280
Rhabdomyolysis 118.36 9.92 368 576896 102763 79064361
Blood pressure systolic increased 114.37 9.92 854 576410 66132 79100992
Intentional product misuse 113.93 9.92 333 576931 94832 79072292
Intentional self-injury 112.13 9.92 47 577217 32372 79134752
Neutropenia 111.67 9.92 1440 575824 286270 78880854
Ill-defined disorder 110.87 9.92 837 576427 65038 79102086
Poisoning 110.22 9.92 24 577240 25248 79141876
Device expulsion 109.90 9.92 26 577238 25835 79141289
Product use in unapproved indication 109.01 9.92 1222 576042 249137 78917987
Contusion 108.20 9.92 1594 575670 147182 79019942
Tachycardia 107.74 9.92 798 576466 176970 78990154
Pregnancy 107.44 9.92 432 576832 26419 79140705
Joint effusion 105.90 9.92 329 576935 17685 79149439
Abortion spontaneous 105.00 9.92 458 576806 29049 79138075
Condition aggravated 102.87 9.92 4522 572742 496602 78670522
Depressed level of consciousness 101.88 9.92 358 576906 96294 79070830
Hypermagnesaemia 101.57 9.92 79 577185 1165 79165959
Interstitial lung disease 101.04 9.92 1253 576011 111347 79055777
Metabolic acidosis 100.09 9.92 287 576977 82242 79084882
Multiple organ dysfunction syndrome 98.45 9.92 491 576773 119755 79047369
Grip strength decreased 98.25 9.92 365 576899 21504 79145620
Blood pressure diastolic decreased 93.41 9.92 450 576814 29766 79137358
Drug withdrawal syndrome 93.16 9.92 69 577195 34649 79132475
Somnolence 93.12 9.92 1195 576069 237786 78929338
Syncope 91.26 9.92 844 576420 178605 78988519
Electrocardiogram QT prolonged 91.16 9.92 341 576923 90045 79077079
Cholestasis 90.79 9.92 148 577116 51961 79115163
Constipation 90.12 9.92 1473 575791 281577 78885547
Enthesopathy 86.65 9.92 231 577033 11377 79155747
Inflammation 86.58 9.92 1049 576215 92704 79074420
Myocardial infarction 86.47 9.92 883 576381 183246 78983878
Osteoporosis 86.30 9.92 679 576585 53433 79113691
Anxiety 85.96 9.92 1273 575991 247239 78919885
Hepatocellular injury 85.93 9.92 132 577132 47461 79119663
Rheumatoid nodule 85.09 9.92 299 576965 17139 79149985
Rash 85.05 9.92 5055 572209 573303 78593821
Drug ineffective for unapproved indication 84.25 9.92 151 577113 51087 79116037
Disturbance in attention 84.17 9.92 149 577115 50652 79116472
Disability assessment scale score increased 83.87 9.92 114 577150 3344 79163780
Dyspnoea 83.71 9.92 5218 572046 851807 78315317
Asthenia 80.12 9.92 2963 574301 508726 78658398
Live birth 79.38 9.92 307 576957 18437 79148687
Myalgia 79.25 9.92 910 576354 184731 78982393
Cognitive disorder 78.48 9.92 252 577012 69674 79097450
Foot deformity 78.41 9.92 364 576900 23710 79143414
Cardio-respiratory arrest 78.38 9.92 462 576802 108048 79059076
Febrile neutropenia 77.92 9.92 1189 576075 229810 78937314
Psoriasis 77.41 9.92 990 576274 88597 79078527
Respiratory depression 75.32 9.92 54 577210 27576 79139548
Juvenile idiopathic arthritis 74.38 9.92 128 577136 4635 79162489
Suicidal ideation 73.77 9.92 293 576971 76047 79091077
Pulmonary fibrosis 73.38 9.92 559 576705 43553 79123571
Tremor 73.27 9.92 832 576432 169251 78997873
Vision blurred 72.76 9.92 458 576806 105440 79061684
Bone erosion 72.09 9.92 288 576976 17559 79149565
Tenosynovitis 71.89 9.92 262 577002 15292 79151832
Hepatic failure 71.23 9.92 217 577047 60995 79106129
Psychotic disorder 70.82 9.92 119 577145 41283 79125841
Heart rate decreased 69.00 9.92 796 576468 69520 79097604
Mydriasis 68.82 9.92 21 577243 17622 79149502
Intentional product use issue 68.09 9.92 1510 575754 150602 79016522
Polyarthritis 67.29 9.92 218 577046 11984 79155140
Immune reconstitution inflammatory syndrome 67.16 9.92 10 577254 13831 79153293
Hypoglycaemia 65.45 9.92 448 576816 101146 79065978
Respiratory failure 65.23 9.92 919 576345 179992 78987132
Blood cholesterol increased 65.22 9.92 908 576356 82812 79084312
Joint destruction 65 9.92 137 577127 5788 79161336
Neuropathy peripheral 64.13 9.92 683 576581 140622 79026502
Caesarean section 63.83 9.92 218 577046 12317 79154807
Balance disorder 63.15 9.92 437 576827 98420 79068704
Joint range of motion decreased 62.98 9.92 435 576829 32847 79134277
Acute hepatic failure 61.92 9.92 76 577188 30037 79137087
Gastrointestinal disorder 61.13 9.92 1233 576031 120972 79046152
Unresponsive to stimuli 60.57 9.92 204 577060 55584 79111540
Cytomegalovirus infection 60.43 9.92 137 577127 42507 79124617
Seizure 60.29 9.92 982 576282 187852 78979272
Loss of personal independence in daily activities 60.28 9.92 1061 576203 101519 79065605
Hyponatraemia 59.76 9.92 916 576348 176932 78990192
Musculoskeletal pain 58.49 9.92 1054 576210 101300 79065824
Joint laxity 57.95 9.92 78 577186 2266 79164858
Thrombocytopenia 57.64 9.92 1470 575794 263789 78903335
Nodule 57.61 9.92 323 576941 22671 79144453
Substance abuse 57.58 9.92 5 577259 10521 79156603
Sedation complication 57.02 9.92 21 577243 15648 79151476
Hallucination 56.28 9.92 376 576888 85369 79081755
Injection site erythema 56.10 9.92 836 576428 77361 79089763
Neurotoxicity 56.05 9.92 93 577171 32425 79134699
Gestational diabetes 55.06 9.92 133 577131 6160 79160964
Pain in extremity 54.95 9.92 3194 574070 361344 78805780
Irritability 54.47 9.92 137 577127 41007 79126117
Pathogen resistance 54.29 9.92 18 577246 14324 79152800
Emotional distress 53.76 9.92 132 577132 39837 79127287
Localised infection 53.72 9.92 460 576804 37115 79130009
Femur fracture 53.60 9.92 470 576794 38182 79128942
Injection site pruritus 53.47 9.92 504 576760 41779 79125345
Joint stiffness 53.30 9.92 490 576774 40340 79126784
Suspected suicide 52.82 9.92 7 577257 10569 79156555
Blood pressure diastolic increased 52.72 9.92 227 577037 14315 79152809
No adverse event 52.28 9.92 120 577144 37072 79130052
Hypothermia 51.59 9.92 53 577211 22693 79144431
Ejection fraction decreased 51.54 9.92 108 577156 34469 79132655
Ventricular tachycardia 50.72 9.92 146 577118 41789 79125335
Disorientation 50.41 9.92 258 577006 62518 79104606
Alanine aminotransferase abnormal 50.33 9.92 160 577104 8707 79158417
Diabetic ketoacidosis 49.68 9.92 108 577156 34014 79133110
Red blood cell sedimentation rate 49.11 9.92 118 577146 5447 79161677
Respiratory distress 49.01 9.92 236 577028 58103 79109021
Agranulocytosis 48.65 9.92 165 577099 44865 79122259
Fracture 48.63 9.92 297 576967 21504 79145620
Orthostatic hypotension 48.48 9.92 225 577039 55939 79111185
Flushing 48.44 9.92 407 576857 87861 79079263
Aggression 48.34 9.92 197 577067 50761 79116363
Speech disorder 48.25 9.92 216 577048 54229 79112895
Type 2 diabetes mellitus 47.97 9.92 628 576636 56494 79110630
Coronary artery disease 47.68 9.92 278 576986 65196 79101928
Dizziness 47.67 9.92 3226 574038 523215 78643909
Drug use disorder 47.62 9.92 4 577260 8647 79158477
Cerebrovascular accident 47.46 9.92 814 576450 154478 79012646
Disability 47.29 9.92 247 577017 16873 79150251
Encephalopathy 47.06 9.92 290 576974 67107 79100017
Body temperature decreased 46.74 9.92 395 576869 31750 79135374
Mucormycosis 46.39 9.92 4 577260 8465 79158659
Dysarthria 46.17 9.92 293 576971 67329 79099795
Withdrawal syndrome 46.10 9.92 77 577187 26777 79140347
Basal cell carcinoma 46.02 9.92 443 576821 36932 79130192
Anaphylactic shock 46.01 9.92 122 577142 35874 79131250
Post transplant lymphoproliferative disorder 45.89 9.92 13 577251 11451 79155673
Injection site reaction 45.88 9.92 602 576662 54183 79112941
Creatinine renal clearance decreased 45.74 9.92 42 577222 18960 79148164
Vomiting 44.99 9.92 4179 573085 661649 78505475
Hyperglycaemia 44.88 9.92 311 576953 70024 79097100
Cardiac failure congestive 44.63 9.92 743 576521 141659 79025465
Shock 44.09 9.92 164 577100 43384 79123740
Bronchospasm 43.87 9.92 70 577194 24789 79142335
Infective pulmonary exacerbation of cystic fibrosis 43.85 9.92 19 577245 12832 79154292
Neuroleptic malignant syndrome 43.72 9.92 83 577181 27476 79139648
Posterior reversible encephalopathy syndrome 43.61 9.92 77 577187 26204 79140920
Urticaria 43.58 9.92 1014 576250 184187 78982937
Exposure to toxic agent 43.56 9.92 7 577257 9151 79157973
Muscle twitching 43.45 9.92 70 577194 24694 79142430
Tongue disorder 43.10 9.92 208 577056 13767 79153357
Depression 43.00 9.92 1217 576047 215573 78951551
Fatigue 42.95 9.92 7500 569764 922227 78244897
Neoplasm progression 42.88 9.92 210 577054 51472 79115652
Extrapyramidal disorder 42.79 9.92 61 577203 22618 79144506
Haematotoxicity 42.74 9.92 30 577234 15489 79151635
Chest discomfort 42.69 9.92 722 576542 137322 79029802
Myoclonus 42.41 9.92 85 577179 27575 79139549
Leukopenia 42.29 9.92 591 576673 115922 79051202
Multiple sclerosis relapse 42.21 9.92 183 577081 46350 79120774
Wrong technique in product usage process 42.20 9.92 337 576927 73538 79093586
Blood pressure increased 41.85 9.92 1901 575363 209459 78957665
Abnormal behaviour 41.74 9.92 130 577134 36291 79130833
Coagulopathy 41.64 9.92 128 577136 35878 79131246
Fear 41.62 9.92 59 577205 21927 79145197
Miosis 41.56 9.92 32 577232 15757 79151367
Tendonitis 41.34 9.92 305 576959 23525 79143599
Laryngitis 41.31 9.92 227 577037 15812 79151312
Product quality issue 41.16 9.92 118 577146 33822 79133302
Pancytopenia 41.13 9.92 1527 575737 164218 79002906
Cardiogenic shock 41.04 9.92 160 577104 41754 79125370
Adverse event 40.97 9.92 638 576626 59576 79107548
Latent tuberculosis 40.89 9.92 81 577183 3272 79163852
Psychomotor hyperactivity 40.84 9.92 37 577227 16812 79150312
Venoocclusive liver disease 40.81 9.92 17 577247 11754 79155370
Mental status changes 40.81 9.92 300 576964 66659 79100465
Paradoxical drug reaction 40.46 9.92 3 577261 7182 79159942
Premature labour 40.20 9.92 143 577121 8247 79158877
Eosinophilia 40.12 9.92 180 577084 45165 79121959
Accidental overdose 40.11 9.92 149 577115 39432 79127692
Aspergillus infection 39.78 9.92 48 577216 19113 79148011
Forced expiratory volume decreased 39.44 9.92 5 577259 7809 79159315
Toxic epidermal necrolysis 39.43 9.92 177 577087 44404 79122720
Blood parathyroid hormone decreased 39.38 9.92 166 577098 10370 79156754
Thrombotic microangiopathy 39.30 9.92 53 577211 20116 79147008
Anaphylactic reaction 39.12 9.92 402 576862 83341 79083783
Skin ulcer 38.48 9.92 578 576686 53572 79113552
Nausea 38.25 9.92 6218 571046 950978 78216146
Neck deformity 37.81 9.92 56 577208 1781 79165343
Mobility decreased 37.78 9.92 1155 576109 121020 79046104
Liver disorder 37.66 9.92 735 576529 71682 79095442
Lip swelling 37.66 9.92 160 577104 40751 79126373
Diarrhoea 37.34 9.92 5700 571564 874789 78292335
Tenderness 36.78 9.92 295 576969 23347 79143777
Second primary malignancy 36.62 9.92 30 577234 14320 79152804
Drug level increased 36.54 9.92 155 577109 39496 79127628
Torsade de pointes 36.38 9.92 52 577212 19260 79147864
Off label use 36.37 9.92 5892 571372 901323 78265801
Granuloma skin 36.22 9.92 147 577117 9027 79158097
Acute generalised exanthematous pustulosis 36.06 9.92 43 577221 17211 79149913
Cardiac failure 35.81 9.92 850 576414 153992 79013132
Maternal exposure before pregnancy 35.70 9.92 90 577174 4283 79162841
Acute chest syndrome 35.66 9.92 50 577214 1511 79165613
Synovial cyst 35.63 9.92 156 577108 9909 79157215
Herpes zoster 35.52 9.92 904 576360 92179 79074945
Ischaemic stroke 35.38 9.92 122 577142 33009 79134115
Acute graft versus host disease 34.74 9.92 15 577249 10152 79156972
Feeling abnormal 34.35 9.92 883 576381 158316 79008808
Bradyphrenia 34.34 9.92 17 577247 10623 79156501
Unintentional medical device removal 34.29 9.92 7 577257 7705 79159419
Hepatotoxicity 34.29 9.92 224 577040 51128 79115996
Device difficult to use 34.14 9.92 28 577236 13357 79153767
Transplant rejection 34.05 9.92 55 577209 19382 79147742
Fluid retention 33.90 9.92 332 576932 69477 79097647
Hepatic function abnormal 33.73 9.92 729 576535 72378 79094746
Pulmonary embolism 33.68 9.92 965 576299 170689 78996435
Oropharyngeal pain 33.60 9.92 1033 576231 108320 79058804
Brain oedema 33.53 9.92 84 577180 25179 79141945
Arrhythmia 33.40 9.92 283 576981 60989 79106135
Rash maculo-papular 33.34 9.92 253 577011 55825 79111299
Wheelchair user 33.31 9.92 109 577155 6023 79161101
Hypoxia 33.23 9.92 536 576728 102707 79064417
Injection site swelling 33.07 9.92 502 576762 46630 79120494
Adenovirus infection 33.04 9.92 10 577254 8437 79158687
Joint dislocation 33.00 9.92 223 577041 16716 79150408
Chronic kidney disease 32.80 9.92 313 576951 65841 79101283
Tuberculosis 32.61 9.92 205 577059 14993 79152131
Hyperthermia 32.58 9.92 50 577214 17987 79149137
Facet joint syndrome 32.57 9.92 165 577099 11137 79155987
Lip dry 32.48 9.92 207 577057 15211 79151913
Pancreatitis acute 32.30 9.92 218 577046 49386 79117738
Hemiparesis 32.25 9.92 130 577134 33603 79133521
Aphasia 32.15 9.92 202 577062 46530 79120594
Premature delivery 31.84 9.92 284 576980 23183 79143941
Panniculitis 31.80 9.92 175 577089 12196 79154928
BK virus infection 31.70 9.92 12 577252 8792 79158332
Therapeutic response decreased 31.61 9.92 669 576595 66184 79100940
Bursitis 31.33 9.92 397 576867 35447 79131677
Multiple fractures 31.21 9.92 128 577136 7898 79159226
Status epilepticus 31.15 9.92 86 577178 24955 79142169
Blood glucose increased 30.96 9.92 616 576648 114359 79052765
Haematoma 30.79 9.92 236 577028 51959 79115165
Polyneuropathy 30.75 9.92 82 577182 24069 79143055
Peripheral venous disease 30.73 9.92 209 577055 15700 79151424
Disease recurrence 30.69 9.92 190 577074 43919 79123205
Maternal exposure timing unspecified 30.61 9.92 102 577162 5690 79161434
Acute respiratory distress syndrome 30.56 9.92 190 577074 43877 79123247
Fear of injection 30.50 9.92 121 577143 7353 79159771
Limb deformity 30.48 9.92 75 577189 3515 79163609
Atrial fibrillation 30.40 9.92 1148 576116 196738 78970386
Premature rupture of membranes 30.40 9.92 81 577183 3988 79163136
Tachypnoea 30.38 9.92 124 577140 31939 79135185
Pre-eclampsia 30.37 9.92 116 577148 6925 79160199
Lethargy 30.34 9.92 410 576854 80882 79086242
Product administration error 30.27 9.92 123 577141 31723 79135401
Chest pain 30.20 9.92 1703 575561 280601 78886523
Progressive multifocal leukoencephalopathy 30.15 9.92 65 577199 20535 79146589
Akathisia 29.95 9.92 31 577233 13228 79153896
Restlessness 29.94 9.92 205 577059 46287 79120837
Polyomavirus-associated nephropathy 29.91 9.92 3 577261 5624 79161500
Asthma 29.76 9.92 747 576517 134348 79032776
Red blood cell count decreased 29.65 9.92 583 576681 56930 79110194
Non-small cell lung cancer 29.28 9.92 107 577157 6253 79160871
Neck mass 29.26 9.92 84 577180 4320 79162804
Anhedonia 29.18 9.92 39 577225 14859 79152265
Pulmonary oedema 29.13 9.92 456 576808 87798 79079326
Haematocrit decreased 29.13 9.92 614 576650 60698 79106426
Ankylosing spondylitis 28.97 9.92 169 577095 12036 79155088
Blood creatine phosphokinase increased 28.95 9.92 322 576942 65768 79101356
Sexual dysfunction 28.94 9.92 10 577254 7753 79159371
Malignant mediastinal neoplasm 28.93 9.92 43 577221 1372 79165752
Bronchopulmonary aspergillosis 28.92 9.92 75 577189 22219 79144905
Bone pain 28.82 9.92 261 577003 55481 79111643
Adjustment disorder with depressed mood 28.57 9.92 136 577128 8950 79158174
Electrocardiogram QRS complex prolonged 28.46 9.92 22 577242 10811 79156313
Smear cervix abnormal 28.24 9.92 59 577205 2477 79164647
Haemoglobin decreased 28.23 9.92 1918 575346 220201 78946923
Clostridium difficile colitis 28.05 9.92 129 577135 32154 79134970
Lupus-like syndrome 27.94 9.92 184 577080 13673 79153451
Ulcer 27.94 9.92 336 576928 29636 79137488
Accidental exposure to product 27.91 9.92 124 577140 31198 79135926
Leukocytosis 27.79 9.92 192 577072 43263 79123861
Retinitis 27.74 9.92 97 577167 5546 79161578
Deep vein thrombosis postoperative 27.57 9.92 152 577112 10600 79156524
Drug hypersensitivity 27.45 9.92 1829 575435 297087 78870037
Anti-cyclic citrullinated peptide antibody 27.40 9.92 99 577165 5753 79161371
Vertigo 27.40 9.92 344 576920 68738 79098386
Affective disorder 27.29 9.92 13 577251 8306 79158818
Muscle spasms 27.21 9.92 1012 576252 173718 78993406
Drug tolerance decreased 27.19 9.92 174 577090 12804 79154320
Arthritis infective 26.89 9.92 125 577139 8146 79158978
Hypertransaminasaemia 26.80 9.92 28 577236 11896 79155228
Spinal stenosis 26.76 9.92 201 577063 15590 79151534
Febrile bone marrow aplasia 26.62 9.92 33 577231 12987 79154137
Joint injury 26.52 9.92 345 576919 30990 79136134
Skin exfoliation 26.35 9.92 263 577001 54837 79112287
Rotator cuff repair 26.30 9.92 48 577216 1822 79165302
Dystonia 26.24 9.92 74 577190 21325 79145799
International normalised ratio increased 26.22 9.92 443 576821 84278 79082846
Breast cancer stage I 26.09 9.92 8 577256 6692 79160432
Exostosis 26.03 9.92 210 577054 16648 79150476
Injection site bruising 25.85 9.92 429 576835 40573 79126551
Tenosynovitis stenosans 25.81 9.92 64 577200 3014 79164110
Muscle spasticity 25.80 9.92 75 577189 21400 79145724
Acute myocardial infarction 25.78 9.92 397 576867 76639 79090485
Melaena 25.75 9.92 299 576965 60591 79106533
Haemorrhage intracranial 25.64 9.92 100 577164 26093 79141031
Platelet count decreased 25.64 9.92 1686 575578 192978 78974146
Wound infection 25.54 9.92 276 576988 23715 79143409
Paranoia 25.49 9.92 65 577199 19367 79147757
Therapy partial responder 25.38 9.92 55 577209 17342 79149782
Palpitations 25.28 9.92 710 576554 125900 79041224
Synovial fluid analysis 25.25 9.92 54 577210 2305 79164819
Acute coronary syndrome 25.24 9.92 74 577190 21059 79146065
Coordination abnormal 25.03 9.92 55 577209 17257 79149867
Muscle rigidity 24.94 9.92 68 577196 19814 79147310
Haemorrhage 24.88 9.92 487 576777 90631 79076493
Visual acuity reduced 24.87 9.92 119 577145 29350 79137774
Hyperkalaemia 24.81 9.92 634 576630 113764 79053360
Mania 24.80 9.92 60 577204 18200 79148924
Ear infection 24.64 9.92 368 576896 34064 79133060
Temperature regulation disorder 24.64 9.92 6 577258 5847 79161277
Anuria 24.61 9.92 74 577190 20889 79146235
Haemodynamic instability 24.50 9.92 56 577208 17326 79149798
Rheumatoid lung 24.46 9.92 77 577187 4168 79162956
Endophthalmitis 24.45 9.92 8 577256 6420 79160704
Cardiomyopathy 24.40 9.92 116 577148 28658 79138466
Foot fracture 24.39 9.92 255 577009 21726 79145398
Sinus bradycardia 24.32 9.92 97 577167 25150 79141974
Rash erythematous 24.31 9.92 284 576980 57485 79109639
Respiration abnormal 24.31 9.92 13 577251 7775 79159349
Poor venous access 24.29 9.92 219 577045 17930 79149194
Renal injury 24.29 9.92 54 577210 16873 79150251
Multiple-drug resistance 24.29 9.92 17 577247 8791 79158333
Scleritis 24.18 9.92 78 577186 4278 79162846
Rebound effect 24.16 9.92 11 577253 7215 79159909
Ventricular fibrillation 24.08 9.92 134 577130 31792 79135332
Graft versus host disease 24.06 9.92 45 577219 14981 79152143
Cardiotoxicity 24.01 9.92 32 577232 12207 79154917
Palmar-plantar erythrodysaesthesia syndrome 23.95 9.92 141 577123 32993 79134131
Pancreatitis 23.77 9.92 351 576913 68224 79098900
Asphyxia 23.66 9.92 30 577234 11690 79155434
Injection site pain 23.59 9.92 1158 576106 128680 79038444
Nocardiosis 23.56 9.92 6 577258 5673 79161451
Oral herpes 23.54 9.92 303 576961 27151 79139973
Chills 23.42 9.92 935 576329 159299 79007825
Dislocation of vertebra 23.38 9.92 116 577148 7764 79159360
Respiratory acidosis 23.31 9.92 28 577236 11172 79155952
Loose body in joint 23.17 9.92 37 577227 1258 79165866
Labelled drug-drug interaction medication error 23.14 9.92 112 577152 27538 79139586
Sciatica 22.98 9.92 353 576911 32869 79134255
Prescribed underdose 22.93 9.92 320 576944 29194 79137930
Myelosuppression 22.93 9.92 184 577080 40112 79127012
Venoocclusive disease 22.90 9.92 3 577261 4570 79162554
Injection site rash 22.69 9.92 214 577050 17740 79149384
Nephropathy toxic 22.62 9.92 74 577190 20345 79146779
Dehydration 22.55 9.92 1520 575744 246667 78920457
Immunodeficiency 22.51 9.92 249 577015 21519 79145605
Dyspnoea exertional 22.40 9.92 470 576794 86603 79080521
Pruritus genital 22.33 9.92 3 577261 4483 79162641
Graft versus host disease in gastrointestinal tract 22.33 9.92 9 577255 6347 79160777
Acidosis 22.32 9.92 71 577193 19691 79147433
Angina pectoris 22.28 9.92 253 577011 51479 79115645
Cyanosis 22.25 9.92 100 577164 25082 79142042
Product prescribing error 22.23 9.92 212 577052 44601 79122523
Bradypnoea 22.21 9.92 8 577256 6044 79161080
Skin papilloma 22.20 9.92 93 577171 5793 79161331
Acute graft versus host disease in skin 22.17 9.92 14 577250 7644 79159480
Sleep terror 22.15 9.92 3 577261 4455 79162669
Generalised tonic-clonic seizure 22.09 9.92 207 577057 43703 79123421
Device use error 21.95 9.92 12 577252 7089 79160035
Synovial disorder 21.93 9.92 46 577218 1937 79165187
Potentiating drug interaction 21.82 9.92 19 577245 8800 79158324
Sinus tachycardia 21.71 9.92 167 577097 36741 79130383
Gastroenteritis viral 21.69 9.92 275 576989 24556 79142568
Mental disorder 21.69 9.92 135 577129 31167 79135957
Dysgeusia 21.47 9.92 288 576976 56889 79110235
Tardive dyskinesia 21.40 9.92 27 577237 10544 79156580
Malignant melanoma 21.35 9.92 181 577083 14560 79152564
Pulseless electrical activity 21.30 9.92 44 577220 14116 79153008
Hallucination, visual 21.23 9.92 144 577120 32585 79134539
Hepatic cirrhosis 21.20 9.92 363 576901 34543 79132581
Myopathy 21.10 9.92 77 577187 20486 79146638
Fracture delayed union 21.10 9.92 47 577217 2063 79165061
Klebsiella infection 21.08 9.92 52 577212 15668 79151456
Haemophagocytic lymphohistiocytosis 20.97 9.92 84 577180 21753 79145371
Hydrops foetalis 20.95 9.92 27 577237 751 79166373
Colorectal cancer 20.94 9.92 19 577245 8628 79158496
Skin cancer 20.91 9.92 183 577081 14857 79152267
Pulmonary arterial hypertension 20.89 9.92 120 577144 28246 79138878
Drug eruption 20.88 9.92 440 576824 43495 79123629
Hepatitis cholestatic 20.87 9.92 43 577221 13809 79153315
Diabetes insipidus 20.85 9.92 6 577258 5231 79161893
Drug screen positive 20.63 9.92 9 577255 6054 79161070
Threatened labour 20.60 9.92 24 577240 600 79166524
Paraesthesia 20.46 9.92 1055 576209 175268 78991856
Virologic failure 20.40 9.92 3 577261 4188 79162936
Upper respiratory tract inflammation 20.39 9.92 70 577194 3965 79163159
Product dose omission issue 20.37 9.92 1529 575735 246008 78921116
Drug abuser 20.34 9.92 9 577255 6004 79161120
Cytokine release syndrome 20.19 9.92 165 577099 35833 79131291
Ultrasound antenatal screen 20.17 9.92 25 577239 668 79166456
Obesity 20.16 9.92 362 576902 34763 79132361
Cleft lip and palate 20.03 9.92 25 577239 673 79166451
Compartment syndrome 19.91 9.92 6 577258 5076 79162048
Acute respiratory failure 19.86 9.92 307 576957 59234 79107890
Depressed mood 19.76 9.92 240 577024 48240 79118884
Memory impairment 19.73 9.92 637 576627 111097 79056027
Device leakage 19.70 9.92 30 577234 10826 79156298
Blood calcium decreased 19.66 9.92 142 577122 31677 79135447
Jaundice 19.57 9.92 270 576994 53079 79114045
Personality change 19.54 9.92 27 577237 10143 79156981
Hyperlactacidaemia 19.53 9.92 8 577256 5587 79161537
Pain in jaw 19.37 9.92 227 577037 45924 79121200
Intracranial pressure increased 19.32 9.92 19 577245 8303 79158821
Erectile dysfunction 19.28 9.92 49 577215 14615 79152509
Joint noise 19.27 9.92 68 577196 3906 79163218
Human antichimeric antibody positive 19.24 9.92 39 577225 1602 79165522
Panic attack 19.17 9.92 100 577164 24116 79143008
Nasal polyps 19.10 9.92 15 577249 7312 79159812
Epstein-Barr virus infection 19.08 9.92 48 577216 14368 79152756
Coronary arterial stent insertion 18.99 9.92 10 577254 6034 79161090
Uterine perforation 18.98 9.92 11 577253 6292 79160832
Renal tubular necrosis 18.94 9.92 105 577159 24934 79142190
Dyskinesia 18.88 9.92 220 577044 44553 79122571
Accidental death 18.86 9.92 4 577260 4287 79162837
Blood lactic acid increased 18.83 9.92 40 577224 12704 79154420
Mouth ulceration 18.73 9.92 386 576878 38008 79129116
Finger deformity 18.73 9.92 105 577159 7369 79159755
Cytopenia 18.58 9.92 80 577184 20303 79146821
Bone disorder 18.58 9.92 216 577048 18897 79148227
Antinuclear antibody positive 18.56 9.92 109 577155 7781 79159343
Pseudomonas infection 18.48 9.92 83 577181 20820 79146304
Dry skin 18.39 9.92 364 576900 67631 79099493
Iodine allergy 18.30 9.92 22 577242 569 79166555
Osteomyelitis 18.26 9.92 337 576927 32528 79134596
Cellulitis 18.23 9.92 965 576299 108095 79059029
Transaminases increased 18.22 9.92 264 577000 51479 79115645
Proteinuria 18.22 9.92 149 577115 32353 79134771
Prescribed overdose 18.20 9.92 380 576884 37503 79129621
Foot operation 18.17 9.92 86 577178 5647 79161477
Loss of consciousness 18.15 9.92 1012 576252 166931 79000193
Atrial tachycardia 18.09 9.92 15 577249 7118 79160006
Breast feeding 18.07 9.92 24 577240 688 79166436
Bronchitis 18.01 9.92 1136 576128 129508 79037616
Polyhydramnios 17.98 9.92 39 577225 1681 79165443
Liver injury 17.97 9.92 537 576727 56077 79111047
Multiple allergies 17.95 9.92 30 577234 10430 79156694
Respiratory disorder 17.92 9.92 223 577041 44633 79122491
Hyperbilirubinaemia 17.90 9.92 104 577160 24414 79142710
Influenza 17.87 9.92 1127 576137 128479 79038645
Anger 17.79 9.92 64 577200 17098 79150026
Trisomy 18 17.77 9.92 22 577242 587 79166537
Myocardial ischaemia 17.71 9.92 110 577154 25409 79141715
Toxic skin eruption 17.68 9.92 92 577172 22201 79144923
Nightmare 17.68 9.92 112 577152 25749 79141375
Face oedema 17.65 9.92 125 577139 28011 79139113
Pleuritic pain 17.64 9.92 130 577134 10022 79157102
Autoimmune disorder 17.63 9.92 191 577073 16421 79150703
Ankle arthroplasty 17.59 9.92 36 577228 1489 79165635
Presyncope 17.59 9.92 201 577063 40853 79126271
Deep vein thrombosis 17.57 9.92 706 576558 120213 79046911
Multiple drug therapy 17.53 9.92 4 577260 4074 79163050
Anti-neutrophil cytoplasmic antibody positive vasculitis 17.40 9.92 3 577261 3726 79163398
Oxygen saturation decreased 17.40 9.92 1120 576144 127927 79039197
Dysphagia 17.35 9.92 715 576549 121421 79045703
Cross sensitivity reaction 17.29 9.92 3 577261 3709 79163415
Lung neoplasm malignant 17.23 9.92 290 576974 27502 79139622
Surgery 17.18 9.92 333 576931 32433 79134691
Stevens-Johnson syndrome 17.08 9.92 191 577073 38975 79128149
Device dislocation 16.98 9.92 114 577150 25856 79141268
Metabolic disorder 16.97 9.92 25 577239 9145 79157979
Lung disorder 16.90 9.92 729 576535 79828 79087296
Cancer pain 16.85 9.92 79 577185 5166 79161958
Pulmonary tuberculosis 16.82 9.92 106 577158 7759 79159365
Drug tolerance 16.78 9.92 114 577150 8561 79158563
Personality disorder 16.77 9.92 12 577252 6134 79160990
Pharyngitis 16.75 9.92 241 577023 22134 79144990
Gastrointestinal haemorrhage 16.73 9.92 886 576378 146833 79020291
Anticholinergic syndrome 16.65 9.92 3 577261 3608 79163516
Hemiplegia 16.64 9.92 54 577210 14885 79152239
Postoperative wound infection 16.64 9.92 155 577109 12806 79154318
Hypomania 16.63 9.92 18 577246 7526 79159598
Paralysis 16.58 9.92 45 577219 13132 79153992
Injection site warmth 16.53 9.92 172 577092 14635 79152489
Swollen tongue 16.50 9.92 213 577051 42357 79124767
Body height below normal 16.50 9.92 42 577222 2011 79165113
Hyperpyrexia 16.48 9.92 12 577252 6080 79161044
Inappropriate antidiuretic hormone secretion 16.46 9.92 117 577147 26196 79140928
Cerebral haemorrhage 16.43 9.92 306 576958 57367 79109757
Short stature 16.43 9.92 23 577241 694 79166430
Strongyloidiasis 16.40 9.92 4 577260 3894 79163230
Drug ineffective 16.39 9.92 8333 568931 1072580 78094544
Foetal distress syndrome 16.37 9.92 19 577245 473 79166651
Product administered to patient of inappropriate age 16.29 9.92 10 577254 5543 79161581
Catatonia 16.08 9.92 24 577240 8732 79158392
Skin toxicity 16.05 9.92 22 577242 8292 79158832
Disturbance in social behaviour 15.95 9.92 8 577256 4962 79162162
Rhinorrhoea 15.87 9.92 688 576576 75386 79091738
Ingrown hair 15.85 9.92 23 577241 718 79166406
Neutrophil count decreased 15.83 9.92 832 576432 93127 79073997
Unevaluable event 15.82 9.92 295 576969 55290 79111834
Induced labour 15.72 9.92 25 577239 847 79166277
Mood altered 15.69 9.92 71 577193 17776 79149348
Skin necrosis 15.67 9.92 200 577064 17887 79149237
Cholecystitis chronic 15.57 9.92 30 577234 9876 79157248
Alcohol interaction 15.41 9.92 8 577256 4866 79162258
Defaecation disorder 15.35 9.92 22 577242 679 79166445
Complication of device insertion 15.32 9.92 14 577250 6336 79160788
Hepatitis B reactivation 15.30 9.92 13 577251 6095 79161029
Cushingoid 15.30 9.92 120 577144 9432 79157692
Alcohol abuse 15.26 9.92 10 577254 5353 79161771
Pneumonia aspiration 15.18 9.92 611 576653 66356 79100768
Lymphoedema 15.17 9.92 43 577221 12370 79154754
Laryngospasm 15.16 9.92 5 577259 3992 79163132
Obstructive airways disorder 15.11 9.92 150 577114 31309 79135815
Transplant dysfunction 15.08 9.92 18 577246 7203 79159921
Diplopia 15.07 9.92 162 577102 33304 79133820
Renal impairment 15.05 9.92 962 576302 156821 79010303
Radiation inflammation 15.03 9.92 25 577239 880 79166244
Blood creatinine increased 15.03 9.92 944 576320 154113 79013011
Wound infection pseudomonas 14.98 9.92 35 577229 1586 79165538
Lymphopenia 14.97 9.92 145 577119 30412 79136712
Feeling hot 14.90 9.92 324 576940 59410 79107714
Spinal compression fracture 14.89 9.92 188 577076 16770 79150354
Hepatitis acute 14.79 9.92 60 577204 15482 79151642
Aplasia 14.79 9.92 21 577243 7799 79159325
Sickle cell anaemia 14.77 9.92 21 577243 643 79166481
Bacteraemia 14.74 9.92 159 577105 32665 79134459
Radiation pneumonitis 14.72 9.92 62 577202 3871 79163253
Hypotonia 14.70 9.92 46 577218 12824 79154300
Gestational hypertension 14.64 9.92 38 577226 1841 79165283
Crying 14.64 9.92 102 577162 22941 79144183
Metastases to bone 14.61 9.92 110 577154 24317 79142807
Psychomotor skills impaired 14.59 9.92 10 577254 5227 79161897
Swelling face 14.56 9.92 398 576866 70814 79096310
Post procedural infection 14.54 9.92 136 577128 11248 79155876
Pulmonary haemorrhage 14.52 9.92 56 577208 14661 79152463
Candida infection 14.52 9.92 192 577072 38022 79129102
Placental disorder 14.47 9.92 25 577239 908 79166216
Hallucination, auditory 14.46 9.92 89 577175 20604 79146520
Hyperlipidaemia 14.45 9.92 120 577144 25973 79141151
Lymphatic fistula 14.45 9.92 23 577241 780 79166344
Troponin increased 14.42 9.92 81 577183 19174 79147950
Ataxia 14.40 9.92 114 577150 24925 79142199
Normal newborn 14.32 9.92 94 577170 6978 79160146
Mental impairment 14.30 9.92 80 577184 18956 79148168
Lacrimal disorder 14.24 9.92 18 577246 491 79166633
Clear cell renal cell carcinoma 14.18 9.92 46 577218 2530 79164594
Acute pulmonary oedema 14.14 9.92 54 577210 14176 79152948
Atrioventricular block 14.13 9.92 53 577211 13988 79153136
Troponin T increased 14.09 9.92 4 577260 3518 79163606
Dactylitis 14.08 9.92 48 577216 2709 79164415
Chronic graft versus host disease 14.06 9.92 17 577247 6764 79160360
Confusional state 14.03 9.92 2053 575211 315944 78851180
Onychomycosis 13.91 9.92 105 577159 8156 79158968
Gastroenteritis 13.89 9.92 334 576930 33748 79133376
Coronary artery bypass 13.89 9.92 14 577250 6048 79161076
Oesophageal carcinoma 13.84 9.92 38 577226 11046 79156078
Renal cancer 13.76 9.92 44 577220 12182 79154942
Product preparation error 13.71 9.92 13 577251 5780 79161344
Oliguria 13.68 9.92 66 577198 16243 79150881
Femoral hernia incarcerated 13.64 9.92 23 577241 819 79166305
Sepsis 13.60 9.92 1725 575539 267703 78899421
Anal fissure 13.59 9.92 99 577165 7604 79159520
Mitochondrial toxicity 13.49 9.92 3 577261 3111 79164013
Metastasis 13.49 9.92 18 577246 6862 79160262
Abortion threatened 13.46 9.92 16 577248 409 79166715
Hypokalaemia 13.43 9.92 880 576384 143160 79023964
Vascular purpura 13.39 9.92 3 577261 3095 79164029
Cytomegalovirus chorioretinitis 13.37 9.92 12 577252 5478 79161646
Clavicle fracture 13.36 9.92 65 577199 4316 79162808
Endodontic procedure 13.35 9.92 47 577217 2696 79164428
Spinal osteoarthritis 13.34 9.92 184 577080 16743 79150381
Catheter site erythema 13.32 9.92 11 577253 5229 79161895
Rash morbilliform 13.20 9.92 15 577249 6135 79160989
Acute lymphocytic leukaemia recurrent 13.18 9.92 9 577255 4715 79162409
Colon cancer 13.18 9.92 162 577102 14361 79152763
Abortion incomplete 13.18 9.92 3 577261 3061 79164063
Bronchopulmonary aspergillosis allergic 13.16 9.92 3 577261 3058 79164066
Left ventricular dysfunction 13.16 9.92 84 577180 19277 79147847
Visual impairment 13.15 9.92 539 576725 91592 79075532
Reversible cerebral vasoconstriction syndrome 13.14 9.92 3 577261 3054 79164070
Knee operation 13.14 9.92 80 577184 5786 79161338
Hypoventilation 13.07 9.92 20 577244 7204 79159920
Cell death 13.05 9.92 9 577255 4690 79162434
Stillbirth 13.02 9.92 60 577204 3895 79163229
Ileus 12.94 9.92 264 577000 25947 79141177
Antibody test positive 12.88 9.92 47 577217 2745 79164379
Congestive cardiomyopathy 12.84 9.92 43 577221 11737 79155387
Joint warmth 12.82 9.92 33 577231 1591 79165533
Sensitisation 12.81 9.92 4 577260 3307 79163817
Type I hypersensitivity 12.79 9.92 8 577256 4390 79162734
Extra dose administered 12.78 9.92 26 577238 8389 79158735
Pyelonephritis acute 12.77 9.92 81 577183 5942 79161182
Human herpesvirus 6 infection 12.77 9.92 12 577252 5358 79161766
Incorrect route of product administration 12.73 9.92 177 577087 34752 79132372
Wrong product administered 12.73 9.92 29 577235 8983 79158141
Motor dysfunction 12.72 9.92 59 577205 14674 79152450
Nail injury 12.72 9.92 19 577245 609 79166515
Hypertensive crisis 12.68 9.92 93 577171 20677 79146447
Bladder cancer 12.62 9.92 86 577178 19440 79147684
Drug dose omission by device 12.61 9.92 16 577248 6234 79160890
Haematemesis 12.61 9.92 285 576979 51979 79115145
Bronchial secretion retention 12.59 9.92 7 577257 4097 79163027
Bone density increased 12.58 9.92 22 577242 807 79166317
Lymph gland infection 12.57 9.92 18 577246 555 79166569
Haemorrhage in pregnancy 12.50 9.92 30 577234 1384 79165740
Heat illness 12.47 9.92 18 577246 559 79166565
Polyuria 12.46 9.92 61 577203 14953 79152171
Gamma-glutamyltransferase increased 12.40 9.92 301 576963 54379 79112745
Glycosylated haemoglobin increased 12.36 9.92 85 577179 19175 79147949
Placental insufficiency 12.36 9.92 26 577238 1097 79166027
Musculoskeletal disorder 12.29 9.92 221 577043 21227 79145897
Osteoporotic fracture 12.29 9.92 62 577202 4178 79162946
Toothache 12.24 9.92 208 577056 19762 79147362
Diaphragmatic disorder 12.24 9.92 34 577230 1716 79165408
Cervical incompetence 12.22 9.92 17 577247 510 79166614
Throat tightness 12.21 9.92 136 577128 27771 79139353
Tuberculin test positive 12.20 9.92 53 577211 3355 79163769
Lower limb fracture 12.19 9.92 236 577028 22979 79144145
Cryptococcosis 12.18 9.92 5 577259 3488 79163636
Dermatitis atopic 12.17 9.92 35 577229 10021 79157103
Complications of transplanted kidney 12.13 9.92 17 577247 6349 79160775
Stoma site pruritus 12.12 9.92 4 577260 6 79167118
Kidney infection 12.12 9.92 224 577040 21627 79145497
Infusion site pain 12.11 9.92 57 577207 14119 79153005
Joint ankylosis 12.07 9.92 39 577225 2141 79164983
Oligoarthritis 12.03 9.92 20 577244 704 79166420
Blood folate increased 12.00 9.92 17 577247 519 79166605
Oxygen consumption increased 11.99 9.92 11 577253 4968 79162156
Lower respiratory tract congestion 11.97 9.92 59 577205 3938 79163186
Haemoptysis 11.96 9.92 311 576953 55688 79111436
Prostatic specific antigen increased 11.95 9.92 37 577227 10349 79156775
Drug specific antibody 11.92 9.92 44 577220 2584 79164540
Intraocular pressure increased 11.91 9.92 31 577233 9174 79157950
Tooth disorder 11.91 9.92 261 577003 25972 79141152
Brain injury 11.90 9.92 43 577221 11474 79155650
Osteonecrosis 11.90 9.92 156 577108 30939 79136185
Palmoplantar keratoderma 11.90 9.92 6 577258 3710 79163414
Human anti-human antibody test 11.90 9.92 15 577249 408 79166716
Iron overload 11.85 9.92 35 577229 1829 79165295
C-reactive protein 11.85 9.92 69 577195 4910 79162214
Psychiatric decompensation 11.81 9.92 7 577257 3956 79163168
End stage renal disease 11.74 9.92 47 577217 12173 79154951
Neutrophilia 11.71 9.92 25 577239 7926 79159198
Cystitis 11.70 9.92 480 576784 52252 79114872
Hyperprolactinaemia 11.66 9.92 10 577254 4666 79162458
Lung adenocarcinoma 11.62 9.92 97 577167 7767 79159357
Capillary leak syndrome 11.61 9.92 7 577257 3918 79163206
Hepatic cytolysis 11.61 9.92 133 577131 27018 79140106
Fulminant type 1 diabetes mellitus 11.57 9.92 30 577234 1453 79165671
Cytomegalovirus infection reactivation 11.55 9.92 29 577235 8687 79158437
C-reactive protein decreased 11.54 9.92 44 577220 2624 79164500
Device issue 11.51 9.92 133 577131 26975 79140149
Post-traumatic stress disorder 11.50 9.92 11 577253 4870 79162254
Arthritis bacterial 11.46 9.92 109 577155 9057 79158067
Glomerular filtration rate decreased 11.43 9.92 107 577157 22595 79144529
Joint lock 11.43 9.92 50 577214 3175 79163949
Oesophageal fibrosis 11.40 9.92 10 577254 176 79166948
Stress cardiomyopathy 11.34 9.92 42 577222 11124 79156000
Maternal exposure during breast feeding 11.29 9.92 45 577219 2740 79164384
Serum ferritin increased 11.29 9.92 115 577149 9732 79157392
Hypertonia 11.28 9.92 22 577242 7210 79159914
Bone density abnormal 11.27 9.92 48 577216 3012 79164112
Hypoxic-ischaemic encephalopathy 11.18 9.92 25 577239 7795 79159329
Foetal exposure during pregnancy 11.14 9.92 76 577188 5714 79161410
Tumour lysis syndrome 11.14 9.92 115 577149 23824 79143300
Bulbospinal muscular atrophy congenital 11.09 9.92 4 577260 9 79167115
Ascites 11.01 9.92 441 576823 75121 79092003
General physical health deterioration 11.00 9.92 2205 575059 273033 78894091
Anal fistula 10.99 9.92 87 577177 6857 79160267
Toxic encephalopathy 10.99 9.92 44 577220 11396 79155728
Plasma cell myeloma recurrent 10.95 9.92 12 577252 4989 79162135
Lip oedema 10.94 9.92 18 577246 6298 79160826
Spondylitis 10.90 9.92 65 577199 4666 79162458
Colitis ulcerative 10.88 9.92 329 576935 34413 79132711
Hypercapnia 10.88 9.92 31 577233 8904 79158220
Myofascial pain syndrome 10.88 9.92 36 577228 2001 79165123
Cardiac disorder 10.87 9.92 378 576886 65379 79101745
Temperature intolerance 10.87 9.92 35 577229 9670 79157454
Cerebral haematoma 10.86 9.92 26 577238 7916 79159208
Silent thyroiditis 10.82 9.92 10 577254 189 79166935
Graft versus host disease in skin 10.81 9.92 17 577247 6056 79161068
Heparin-induced thrombocytopenia 10.79 9.92 35 577229 9647 79157477
Dissociation 10.78 9.92 8 577256 4013 79163111
Shock haemorrhagic 10.77 9.92 93 577171 19967 79147157
Renal tubular disorder 10.76 9.92 19 577245 6467 79160657
Paresis 10.76 9.92 9 577255 4252 79162872
Sputum discoloured 10.72 9.92 103 577161 21640 79145484
Dyspnoea at rest 10.72 9.92 23 577241 7279 79159845
Ventricular hypokinesia 10.72 9.92 33 577231 9246 79157878
Circulatory collapse 10.69 9.92 200 577064 37468 79129656
Ischaemic cardiomyopathy 10.68 9.92 25 577239 7670 79159454
Incoherent 10.66 9.92 25 577239 7667 79159457
Pulmonary pain 10.66 9.92 62 577202 4411 79162713
Injection site extravasation 10.65 9.92 112 577152 9557 79157567
Benign ovarian tumour 10.64 9.92 13 577251 342 79166782
Rales 10.62 9.92 93 577171 19908 79147216
Thinking abnormal 10.62 9.92 54 577210 13107 79154017
Colitis microscopic 10.61 9.92 41 577223 10727 79156397
Lymphangiosis carcinomatosa 10.57 9.92 37 577227 2117 79165007
Hypercholesterolaemia 10.55 9.92 230 577034 22865 79144259
Platelet count increased 10.52 9.92 224 577040 22182 79144942
Seronegative arthritis 10.51 9.92 64 577200 4628 79162496
Ketoacidosis 10.51 9.92 26 577238 7828 79159296
Immune-mediated myositis 10.51 9.92 6 577258 3461 79163663
Small for dates baby 10.51 9.92 15 577249 461 79166663
Metastases to liver 10.49 9.92 143 577121 28171 79138953
Anal skin tags 10.49 9.92 15 577249 462 79166662
Jaundice cholestatic 10.46 9.92 44 577220 11240 79155884
Frequent bowel movements 10.43 9.92 284 576980 29255 79137869
Immunosuppression 10.43 9.92 140 577124 12663 79154461
Eye swelling 10.42 9.92 132 577132 26336 79140788
Hepatic siderosis 10.42 9.92 9 577255 155 79166969
Neurologic neglect syndrome 10.40 9.92 4 577260 2903 79164221
Device related infection 10.39 9.92 180 577084 34114 79133010
Acute myeloid leukaemia 10.38 9.92 159 577105 30726 79136398
Delivery 10.38 9.92 19 577245 723 79166401
Complication associated with device 10.37 9.92 79 577185 17417 79149707
Pulmonary congestion 10.35 9.92 136 577128 26964 79140160
Folate deficiency 10.35 9.92 50 577214 3310 79163814
Cardiopulmonary failure 10.34 9.92 21 577243 6780 79160344
Cyst 10.33 9.92 149 577115 13691 79153433
Partial seizures 10.32 9.92 32 577232 8946 79158178
Disinhibition 10.30 9.92 3 577261 2595 79164529
Blindness 10.28 9.92 144 577120 28239 79138885
Tubulointerstitial nephritis 10.24 9.92 205 577059 38030 79129094
Mixed liver injury 10.21 9.92 25 577239 7553 79159571
Hyperthyroidism 10.21 9.92 107 577157 22102 79145022
Catheter management 10.19 9.92 7 577257 3656 79163468
Pelvic pain 10.18 9.92 56 577208 13325 79153799
Pulmonary function test abnormal 10.16 9.92 9 577255 4135 79162989
Twin pregnancy 10.16 9.92 21 577243 875 79166249
Upper respiratory tract infection 10.16 9.92 779 576485 90389 79076735
Polydactyly 10.13 9.92 7 577257 85 79167039
Respiratory tract infection viral 10.12 9.92 59 577205 4200 79162924
Diastolic dysfunction 10.12 9.92 42 577222 10769 79156355
Ligament rupture 10.10 9.92 50 577214 3344 79163780
Abortion missed 10.05 9.92 26 577238 1257 79165867
Hepatitis E antibody positive 10.03 9.92 11 577253 257 79166867
Aphthous ulcer 10.02 9.92 175 577089 16714 79150410
Skin ulcer haemorrhage 10.02 9.92 16 577248 544 79166580
Vacuum extractor delivery 10.01 9.92 8 577256 123 79167001
Mucosal inflammation 9.99 9.92 446 576818 75134 79091990
Livedo reticularis 9.96 9.92 9 577255 4094 79163030
Sleep apnoea syndrome 9.95 9.92 195 577069 36283 79130841
Acute lung injury 9.93 9.92 5 577259 3095 79164029
Diabetes mellitus inadequate control 9.93 9.92 120 577144 24144 79142980
Nervousness 9.93 9.92 176 577088 33239 79133885

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02AA02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
ANTACIDS
Magnesium compounds
ATC A06AD02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Osmotically acting laxatives
ATC A12CC10 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
OTHER MINERAL SUPPLEMENTS
Magnesium
MeSH PA D000863 Antacids
MeSH PA D005765 Gastrointestinal Agents
CHEBI has role CHEBI:33287 fertilizers
CHEBI has role CHEBI:65265 antacids

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypocalcemia indication 5291005
Constipation indication 14760008 DOID:2089
Osteoporosis indication 64859006 DOID:11476
Postmenopausal osteoporosis indication 102447009
Indigestion indication 162031009
Hypomagnesemia indication 190855004
Incomplete passage of stool indication 249515001
Peptic ulcer contraindication 13200003 DOID:750
Bipolar disorder contraindication 13746004 DOID:3312
Hyperkalemia contraindication 14140009
Hypocupremia contraindication 19577007
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Metabolic acidosis contraindication 59455009
Diarrhea contraindication 62315008
Blood coagulation disorder contraindication 64779008 DOID:1247
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypercalciuria contraindication 71938000
Gastrointestinal hemorrhage contraindication 74474003
Phototoxicity contraindication 84326006
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Neoplasm of endometrium contraindication 123844007 DOID:1380
Gastrointestinal obstruction contraindication 126765001
Seizure disorder contraindication 128613002
Impaired renal function disorder contraindication 197663003
Osteolysis contraindication 203522001
Hypomania contraindication 231496004
Gastroparesis contraindication 235675006
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Endometrial carcinoma contraindication 254878006 DOID:2871
Esophageal dysmotility contraindication 266434009 DOID:9192
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Primary adrenocortical insufficiency contraindication 373662000
Ketoacidosis in diabetes mellitus contraindication 420422005 DOID:1837
Carcinoma of female breast contraindication 447782002
Genitourinary Tract Infections contraindication
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication
Esophageal Compression contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
12GM/BOT;3.5GM/BOT;10MG/BOT CLENPIQ FERRING PHARMS INC N209589 Nov. 28, 2017 RX SOLUTION ORAL 11191753 June 23, 2034 FOR CLEANSING OF THE COLON AS A PREPARATION FOR COLONOSCOPY
12GM/BOT;3.5GM/BOT;10MG/BOT CLENPIQ FERRING PHARMS INC N209589 Nov. 28, 2017 RX SOLUTION ORAL 9827231 June 26, 2034 FOR CLEANSING THE LARGE INTESTINE AS A PREPARATION FOR COLONOSCOPY

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4020248 VUID
N0000148146 NUI
D01167 KEGG_DRUG
4017641 VANDF
4017717 VANDF
4020248 VANDF
C0024477 UMLSCUI
CHEBI:31794 CHEBI
CHEMBL1200572 ChEMBL_ID
D008277 MESH_DESCRIPTOR_UI
DB01377 DRUGBANK_ID
3A3U0GI71G UNII
6850729 PUBCHEM_CID
6582 RXNORM
40492 MMSL
42624 MMSL
5015 MMSL
5585 MMSL
d03797 MMSL
000788 NDDF
002435 NDDF
419521006 SNOMEDCT_US
66389008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Calcemin Advance HUMAN OTC DRUG LABEL 5 0280-0272 TABLET, FILM COATED 40 mg ORAL Export only 2 sections
Calcemin Silver HUMAN OTC DRUG LABEL 3 0280-0273 TABLET, FILM COATED 40 mg ORAL Export only 2 sections
Magnesium Oxide HUMAN OTC DRUG LABEL 1 0603-0209 TABLET 400 mg ORAL OTC MONOGRAPH FINAL 12 sections
Magnesium Oxide HUMAN OTC DRUG LABEL 1 0603-0213 TABLET 253 mg ORAL OTC MONOGRAPH FINAL 12 sections
Magnesium Oxide HUMAN OTC DRUG LABEL 1 0603-0213 TABLET 253 mg ORAL OTC MONOGRAPH FINAL 12 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 20 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 20 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 25 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 50 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 50 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 20 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 20 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 25 mg ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 50 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Magnesium Oxide HUMAN OTC DRUG LABEL 1 10135-583 TABLET 400 mg ORAL OTC MONOGRAPH FINAL 12 sections
magnesium oxide HUMAN OTC DRUG LABEL 1 10135-721 TABLET 420 mg ORAL OTC monograph final 9 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-100 LIQUID 10 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-101 LIQUID 12 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-103 TABLET, CHEWABLE 15 mg ORAL UNAPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-104 TABLET, CHEWABLE 15 mg ORAL UNAPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-105 TABLET, CHEWABLE 15 mg ORAL UNAPPROVED DRUG OTHER 12 sections
TriStart DHA HUMAN PRESCRIPTION DRUG LABEL 15 15370-250 CAPSULE, LIQUID FILLED 30 mg ORAL UNAPPROVED DRUG OTHER 12 sections
Magnesium Oxide HUMAN OTC DRUG LABEL 1 24689-132 TABLET 400 mg ORAL OTC monograph final 11 sections
SODIUM PICOSULFATE, MAGNESIUM OXIDE AND ANHYDROUS CITRIC ACID HUMAN PRESCRIPTION DRUG LABEL 3 31722-874 POWDER, METERED 3.50 g ORAL ANDA 25 sections
PNV-Select HUMAN PRESCRIPTION DRUG LABEL 18 42192-320 TABLET, FILM COATED 30 ug ORAL unapproved drug other 10 sections
PNV-Omega HUMAN PRESCRIPTION DRUG LABEL 13 42192-332 CAPSULE, GELATIN COATED 45 mg ORAL unapproved drug other 12 sections
MigralexDr. Mauskop HUMAN OTC DRUG LABEL 2 49886-001 TABLET, COATED 75 mg ORAL OTC monograph not final 26 sections
Nestabs ONE HUMAN PRESCRIPTION DRUG LABEL 10 50967-410 CAPSULE, GELATIN COATED 15 mg ORAL unapproved drug other 12 sections
Nestabs ONE HUMAN PRESCRIPTION DRUG LABEL 10 50967-410 CAPSULE, GELATIN COATED 15 mg ORAL unapproved drug other 12 sections
Magnesium Oxide HUMAN OTC DRUG LABEL 1 53808-0684 TABLET 400 mg ORAL OTC MONOGRAPH FINAL 13 sections