magnesium oxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4293 1309-48-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • magnesium oxide
Magnesium oxide (MgO). An inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses.
  • Molecular weight: 40.30
  • Formula: MgO
  • CLOGP: -1.32
  • LIPINSKI: None
  • HAC: 1
  • HDO: 0
  • TPSA: 17.07
  • ALOGS:
  • ROTB: 0

Drug dosage:

DoseUnitRoute
7 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 22, 1982 FDA BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1383.61 9.95 3081 419553 117085 50065405
Systemic lupus erythematosus 1281.92 9.95 3293 419341 137329 50045161
Glossodynia 1103.58 9.95 2755 419879 112814 50069676
Hand deformity 867.83 9.95 2303 420331 97896 50084594
Rheumatoid arthritis 844.69 9.95 3639 418995 198911 49983579
Maternal exposure during pregnancy 772.98 9.95 3006 419628 156772 50025718
Completed suicide 762.75 9.95 100 422534 131789 50050701
Arthropathy 754.29 9.95 2959 419675 154947 50027543
Alopecia 735.04 9.95 4005 418629 241042 49941448
Abdominal discomfort 729.47 9.95 3837 418797 227804 49954686
Wound 705.45 9.95 2214 420420 103580 50078910
Toxicity to various agents 636.92 9.95 505 422129 211994 49970496
Infusion related reaction 543.05 9.95 2823 419811 166734 50015756
Pericarditis 538.41 9.95 1662 420972 77027 50105463
Synovitis 533.79 9.95 2249 420385 121616 50060874
Anti-cyclic citrullinated peptide antibody positive 524.55 9.95 1535 421099 69052 50113438
Discomfort 486.62 9.95 1993 420641 106387 50076103
Contraindicated product administered 483.74 9.95 2490 420144 146468 50036022
Swelling 448.26 9.95 3042 419592 197830 49984660
Joint swelling 409.74 9.95 3470 419164 241816 49940674
Pain 389.10 9.95 6886 415748 572017 49610473
Death 379.77 9.95 1417 421217 323962 49858528
Drug abuse 356.53 9.95 41 422593 59805 50122685
Drug interaction 344.53 9.95 719 421915 198902 49983588
Intentional overdose 336.82 9.95 58 422576 62446 50120044
Rheumatoid factor positive 322.41 9.95 1033 421601 48826 50133664
Product use issue 306.91 9.95 2219 420415 147256 50035234
Duodenal ulcer perforation 304.06 9.95 955 421679 44656 50137834
Helicobacter infection 290.36 9.95 995 421639 48707 50133783
Arthralgia 255.36 9.95 5107 417527 433595 49748895
Hepatic enzyme increased 248.00 9.95 1979 420655 135401 50047089
Exposure during pregnancy 215.51 9.95 1738 420896 119277 50063213
Drug hypersensitivity 213.03 9.95 1227 421407 249783 49932707
Hip arthroplasty 201.74 9.95 636 421998 29793 50152697
Overdose 195.82 9.95 332 422302 99395 50083095
Suicide attempt 190.28 9.95 97 422537 51635 50130855
Knee arthroplasty 186.54 9.95 691 421943 35155 50147335
Musculoskeletal stiffness 182.02 9.95 1755 420879 126726 50055764
Device expulsion 161.43 9.95 24 422610 28798 50153692
Cardiac arrest 160.09 9.95 283 422351 83368 50099122
Drug intolerance 158.67 9.95 2641 419993 216463 49966027
Therapeutic product effect decreased 158.02 9.95 1785 420849 134265 50048225
Treatment failure 155.89 9.95 1797 420837 135840 50046650
Nasopharyngitis 155.31 9.95 2367 420267 190560 49991930
Psoriatic arthropathy 150.82 9.95 784 421850 46248 50136242
Red blood cell sedimentation rate abnormal 139.55 9.95 374 422260 15969 50166521
Lactic acidosis 137.68 9.95 53 422581 33302 50149188
Anxiety 134.04 9.95 900 421734 176706 50005784
Acute kidney injury 127.45 9.95 1253 421381 226805 49955685
Sedation 122.48 9.95 51 422583 30559 50151931
C-reactive protein abnormal 119.59 9.95 505 422129 27304 50155186
Sickle cell anaemia with crisis 116.97 9.95 166 422468 4377 50178113
Rheumatic fever 114.98 9.95 356 422278 16511 50165979
Tremor 114.61 9.95 531 422103 114372 50068118
Hypotension 112.98 9.95 1340 421294 234129 49948361
Swollen joint count increased 111.85 9.95 325 422309 14548 50167942
Bradycardia 111.01 9.95 232 422402 64194 50118296
Dyspnoea 110.33 9.95 3611 419023 543997 49638493
Impaired healing 110.21 9.95 976 421658 68810 50113680
Asthenia 108.56 9.95 1943 420691 317099 49865391
Diarrhoea 107.83 9.95 3927 418707 584549 49597941
Agitation 107.27 9.95 175 422459 53209 50129281
Nausea 106.49 9.95 4814 417820 700584 49481906
Sopor 105.86 9.95 19 422615 19860 50162630
Hypersensitivity 103.25 9.95 2438 420196 212723 49969767
Intentional self-injury 101.77 9.95 33 422601 23079 50159411
Constipation 98.46 9.95 1033 421601 184675 49997815
Dizziness 92.45 9.95 2195 420439 344174 49838316
Product quality issue 87.73 9.95 77 422557 30781 50151709
Electrocardiogram QT prolonged 87.58 9.95 189 422445 51697 50130793
Drug reaction with eosinophilia and systemic symptoms 86.94 9.95 66 422568 28358 50154132
Neutropenia 86.38 9.95 804 421830 147161 50035329
Depressed level of consciousness 86.24 9.95 191 422443 51762 50130728
Somnolence 85.88 9.95 853 421781 154132 50028358
Hyperhidrosis 84.07 9.95 422 422212 89004 50093486
Drug withdrawal syndrome 83.66 9.95 53 422581 25028 50157462
Disease progression 83.65 9.95 464 422170 95402 50087088
Pregnancy 83.32 9.95 476 422158 29101 50153389
Respiratory arrest 82.79 9.95 77 422557 29932 50152558
Drug dependence 82.21 9.95 31 422603 19728 50162762
Live birth 81.78 9.95 312 422322 16096 50166394
Multiple sclerosis relapse 81.59 9.95 146 422488 42818 50139672
Hyponatraemia 78.70 9.95 475 422159 95664 50086826
Coma 76.84 9.95 232 422402 56647 50125843
Renal failure 76.12 9.95 549 422085 106084 50076406
Myalgia 74.95 9.95 670 421964 123649 50058841
Sleep disorder due to general medical condition, insomnia type 74.57 9.95 484 422150 30963 50151527
Syncope 74.16 9.95 529 422105 102473 50080017
Rash 73.70 9.95 4408 418226 433063 49749427
Arthritis 73.56 9.95 1074 421560 85647 50096843
Serotonin syndrome 72.29 9.95 60 422574 24653 50157837
Muscle injury 72.05 9.95 544 422090 36567 50145923
Urticaria 71.38 9.95 714 421920 128847 50053643
Folliculitis 71.16 9.95 566 422068 38659 50143831
Drug resistance 70.72 9.95 35 422599 18954 50163536
Abortion spontaneous 67.37 9.95 587 422047 41185 50141305
Psoriasis 67.24 9.95 876 421758 68124 50114366
Vomiting 67.11 9.95 3155 419479 457603 49724887
Cognitive disorder 67.03 9.95 170 422464 43953 50138537
Cardio-respiratory arrest 65.73 9.95 230 422404 53662 50128828
Intentional product misuse 64.29 9.95 189 422445 46545 50135945
Metabolic acidosis 62.60 9.95 145 422489 38680 50143810
Tachycardia 62.18 9.95 533 422101 99230 50083260
Febrile neutropenia 61.68 9.95 520 422114 97147 50085343
Hepatocellular injury 61.09 9.95 76 422558 25871 50156619
Disturbance in attention 61.01 9.95 104 422530 31082 50151408
Asthma 60.86 9.95 466 422168 88871 50093619
Balance disorder 60.84 9.95 343 422291 70247 50112243
Osteoarthritis 60.70 9.95 856 421778 67750 50114740
Vision blurred 60.53 9.95 396 422238 78251 50104239
Blister 60.35 9.95 1026 421608 84392 50098098
Hypermagnesaemia 60.31 9.95 54 422580 840 50181650
Insomnia 60.28 9.95 1062 421572 173803 50008687
Neuropathy peripheral 60.28 9.95 517 422117 96240 50086250
Cholestasis 60.23 9.95 74 422560 25327 50157163
Fatigue 59.59 9.95 6762 415872 700839 49481651
Muscle spasticity 59.14 9.95 35 422599 17149 50165341
No adverse event 58.60 9.95 120 422514 33458 50149032
Feeling abnormal 57.12 9.95 722 421912 124770 50057720
Juvenile idiopathic arthritis 56.85 9.95 93 422541 2786 50179704
Condition aggravated 56.68 9.95 3028 419606 294030 49888460
Emotional distress 56.61 9.95 95 422539 28568 50153922
Joint effusion 56.40 9.95 237 422397 12784 50169706
Disability assessment scale score increased 56.10 9.95 83 422551 2275 50180215
Injection site erythema 54.74 9.95 905 421729 74031 50108459
Lower respiratory tract infection 54.57 9.95 1107 421527 94094 50088396
Blood pressure fluctuation 53.97 9.95 496 422138 35327 50147163
Caesarean section 53.83 9.95 266 422368 15373 50167117
Encephalopathy 52.67 9.95 128 422506 33583 50148907
Poisoning 52.55 9.95 19 422615 12410 50170080
Anaphylactic reaction 51.41 9.95 254 422380 53801 50128689
Injection site pruritus 50.42 9.95 538 422096 39873 50142617
Myocardial infarction 50.11 9.95 488 422146 88539 50093951
Irritable bowel syndrome 50.08 9.95 653 421981 50788 50131702
Chest discomfort 49.80 9.95 514 422120 92208 50090282
Joint laxity 49.45 9.95 79 422555 2319 50180171
Muscle spasms 49.04 9.95 745 421889 124808 50057682
Basal cell carcinoma 48.54 9.95 348 422286 23008 50159482
Product use in unapproved indication 48.46 9.95 678 421956 115141 50067349
Multiple organ dysfunction syndrome 48.18 9.95 236 422398 50101 50132389
Rhabdomyolysis 47.97 9.95 166 422468 38861 50143629
Seizure 47.57 9.95 695 421939 117179 50065311
Hypoglycaemia 47.45 9.95 258 422376 53323 50129167
Premature labour 46.72 9.95 205 422429 11271 50171219
Respiratory disorder 46.72 9.95 121 422513 31066 50151424
Suicidal ideation 46.71 9.95 271 422363 55114 50127376
Depression 46.34 9.95 1040 421594 164383 50018107
Angioedema 45.80 9.95 161 422473 37515 50144975
C-reactive protein increased 45.70 9.95 795 421839 65679 50116811
Diabetic ketoacidosis 45.69 9.95 49 422585 17823 50164667
Red blood cell sedimentation rate increased 45.69 9.95 410 422224 29006 50153484
Sedation complication 45.35 9.95 9 422625 8757 50173733
Mydriasis 45.35 9.95 16 422618 10611 50171879
Product administration error 45.03 9.95 59 422575 19640 50162850
Neoplasm progression 44.54 9.95 112 422522 29045 50153445
Flushing 44.04 9.95 353 422281 66662 50115828
Ejection fraction decreased 43.86 9.95 54 422580 18466 50164024
Memory impairment 43.83 9.95 437 422197 78923 50103567
Blood pressure diastolic abnormal 43.40 9.95 174 422460 9187 50173303
Fluid retention 43.16 9.95 247 422387 50402 50132088
Cardiac failure 43.13 9.95 416 422218 75624 50106866
Hepatic failure 42.65 9.95 133 422501 32150 50150340
Creatinine renal clearance decreased 42.61 9.95 23 422611 11858 50170632
Foot deformity 42.13 9.95 290 422344 18920 50163570
Hypothermia 42.02 9.95 24 422610 11992 50170498
Speech disorder 41.17 9.95 155 422479 35393 50147097
Osteoporosis 40.91 9.95 563 422071 44316 50138174
Unresponsive to stimuli 39.11 9.95 128 422506 30481 50152009
Type 2 diabetes mellitus 38.93 9.95 449 422185 33926 50148564
Drug ineffective 38.91 9.95 7579 415055 811754 49370736
Gestational diabetes 38.90 9.95 144 422490 7321 50175169
Device dislocation 38.45 9.95 76 422558 21470 50161020
Bone pain 38.29 9.95 234 422400 46995 50135495
Grip strength decreased 38.11 9.95 201 422433 11920 50170570
Contusion 38.06 9.95 1216 421418 110967 50071523
Acute hepatic failure 37.88 9.95 45 422589 15632 50166858
Orthostatic hypotension 37.87 9.95 123 422511 29358 50153132
Neck deformity 37.85 9.95 63 422571 1915 50180575
Disorientation 37.75 9.95 160 422474 35324 50147166
Palmar-plantar erythrodysaesthesia syndrome 37.52 9.95 69 422565 20029 50162461
Accidental overdose 37.42 9.95 66 422568 19467 50163023
Multiple fractures 37.40 9.95 131 422503 6480 50176010
Pulmonary embolism 37.18 9.95 611 422023 101093 50081397
Metastases to bone 37.08 9.95 58 422576 17937 50164553
Vertigo 36.90 9.95 267 422367 51565 50130925
Injection site swelling 36.85 9.95 521 422113 41252 50141238
Wrong technique in product usage process 36.65 9.95 292 422342 55218 50127272
Thrombocytopenia 36.22 9.95 801 421833 126872 50055618
Bone erosion 36.20 9.95 193 422441 11494 50170996
Fibromyalgia 36.15 9.95 552 422082 44426 50138064
Hallucination 35.85 9.95 235 422399 46422 50136068
Blood pressure systolic abnormal 35.54 9.95 143 422491 7563 50174927
Foetal exposure during pregnancy 35.42 9.95 367 422267 26992 50155498
Ill-defined disorder 35.21 9.95 647 421987 54007 50128483
Posterior reversible encephalopathy syndrome 34.85 9.95 44 422590 14884 50167606
Cardiac failure congestive 34.57 9.95 496 422138 83886 50098604
Femur fracture 34.56 9.95 471 422163 36993 50145497
Chest pain 34.31 9.95 1171 421463 175711 50006779
Headache 34.26 9.95 3706 418928 502829 49679661
Hyperglycaemia 34.08 9.95 172 422462 36233 50146257
Drug ineffective for unapproved indication 33.88 9.95 80 422554 21201 50161289
Malignant neoplasm progression 33.63 9.95 385 422249 67739 50114751
Injection site reaction 33.54 9.95 596 422038 49436 50133054
Maternal drugs affecting foetus 33.53 9.95 106 422528 4971 50177519
Hospitalisation 33.51 9.95 384 422250 67553 50114937
Pain in jaw 33.50 9.95 186 422448 38242 50144248
Rheumatoid nodule 33.30 9.95 201 422433 12534 50169956
Blood cholesterol increased 32.95 9.95 646 421988 54569 50127921
Tuberculosis 32.94 9.95 169 422465 9914 50172576
Dysarthria 32.62 9.95 181 422453 37222 50145268
Blood pressure diastolic decreased 32.57 9.95 246 422388 16535 50165955
Cerebrovascular accident 32.28 9.95 576 422058 94104 50088386
Sinusitis 32.15 9.95 1737 420897 168821 50013669
Extrapyramidal disorder 31.53 9.95 31 422603 11739 50170751
Withdrawal syndrome 31.43 9.95 62 422572 17528 50164962
Off label use 31.42 9.95 3476 419158 470950 49711540
Mental status changes 31.38 9.95 176 422458 36096 50146394
Polyneuropathy 31.30 9.95 33 422601 12098 50170392
Blood pressure systolic increased 31.22 9.95 442 422192 35007 50147483
Loss of personal independence in daily activities 31.18 9.95 786 421848 69264 50113226
Dyspnoea exertional 30.90 9.95 276 422358 50957 50131533
Psychotic disorder 30.88 9.95 87 422547 21725 50160765
Obstructive airways disorder 30.79 9.95 52 422582 15600 50166890
Torsade de pointes 30.76 9.95 32 422602 11803 50170687
Crying 30.74 9.95 79 422555 20337 50162153
Bronchospasm 30.49 9.95 48 422586 14806 50167684
Blood glucose increased 30.36 9.95 416 422218 70908 50111582
Polyarthritis 30.31 9.95 139 422495 7788 50174702
Confusional state 30.26 9.95 1257 421377 184671 49997819
Device difficult to use 30.17 9.95 23 422611 9863 50172627
Ventricular septal defect 30.09 9.95 88 422546 3953 50178537
Respiratory failure 30.05 9.95 558 422076 90623 50091867
Pre-eclampsia 29.98 9.95 140 422494 7904 50174586
Immune reconstitution inflammatory syndrome 29.97 9.95 5 422629 5511 50176979
Neurotoxicity 29.90 9.95 48 422586 14692 50167798
Abnormal behaviour 29.65 9.95 76 422558 19582 50162908
Maternal exposure before pregnancy 29.19 9.95 108 422526 5489 50177001
Respiratory distress 29.14 9.95 143 422491 30346 50152144
Bradyphrenia 28.50 9.95 8 422626 6144 50176346
Nightmare 28.48 9.95 57 422577 16029 50166461
Limb deformity 28.46 9.95 82 422552 3652 50178838
Accidental exposure to product 28.38 9.95 98 422536 22959 50159531
Enthesopathy 28.15 9.95 127 422507 7066 50175424
Arrhythmia 27.99 9.95 162 422472 32970 50149520
Tenderness 27.93 9.95 257 422377 18308 50164182
Drug level increased 27.92 9.95 76 422558 19192 50163298
Ischaemic stroke 27.82 9.95 57 422577 15891 50166599
Febrile bone marrow aplasia 27.80 9.95 9 422625 6302 50176188
Palpitations 27.64 9.95 590 422044 93916 50088574
Leukopenia 27.63 9.95 397 422237 67131 50115359
Haemorrhage 27.57 9.95 299 422335 53142 50129348
Stomatitis 27.53 9.95 1071 421563 100273 50082217
Product dose omission issue 27.41 9.95 1255 421379 182583 49999907
Irritability 27.35 9.95 133 422501 28293 50154197
Hypoxia 27.19 9.95 284 422350 50839 50131651
Hypomania 27.04 9.95 3 422631 4502 50177988
Acute generalised exanthematous pustulosis 27.02 9.95 21 422613 8917 50173573
Joint destruction 27.01 9.95 83 422551 3833 50178657
Small for dates baby 26.75 9.95 77 422557 3428 50179062
Shock 26.63 9.95 86 422548 20564 50161926
Injection site pain 26.43 9.95 1157 421477 109867 50072623
Respiratory depression 26.41 9.95 37 422597 11973 50170517
Nodule 26.41 9.95 237 422397 16766 50165724
Pulmonary fibrosis 26.26 9.95 316 422318 24121 50158369
Forced expiratory volume decreased 26.19 9.95 3 422631 4391 50178099
Product adhesion issue 26.17 9.95 3 422631 4389 50178101
Premature rupture of membranes 26.12 9.95 91 422543 4489 50178001
Device use error 26.03 9.95 6 422628 5260 50177230
Anaphylactic shock 25.95 9.95 84 422550 20071 50162419
Complication of device insertion 25.94 9.95 9 422625 6032 50176458
Haematotoxicity 25.90 9.95 17 422617 7878 50174612
Premature delivery 25.87 9.95 307 422327 23356 50159134
Peripheral swelling 25.70 9.95 2025 420609 203911 49978579
Diabetes mellitus inadequate control 25.56 9.95 44 422590 13101 50169389
Tenosynovitis stenosans 25.49 9.95 57 422577 2167 50180323
Latent tuberculosis 25.16 9.95 57 422577 2186 50180304
Loss of consciousness 25.12 9.95 671 421963 103682 50078808
Coagulopathy 25.09 9.95 72 422562 17872 50164618
Infection 25.02 9.95 1721 420913 171233 50011257
Localised infection 25 9.95 324 422310 25161 50157329
Chronic kidney disease 24.98 9.95 212 422422 39559 50142931
Hepatotoxicity 24.71 9.95 130 422504 27096 50155394
Infective pulmonary exacerbation of cystic fibrosis 24.65 9.95 18 422616 7891 50174599
Fear 24.54 9.95 53 422581 14496 50167994
Skin ulcer 24.48 9.95 423 422211 34895 50147595
Pulmonary tuberculosis 24.46 9.95 85 422549 4188 50178302
Metastases to liver 24.37 9.95 86 422548 20018 50162472
Injection site rash 24.37 9.95 224 422410 15953 50166537
Substance abuse 24.12 9.95 3 422631 4121 50178369
Restlessness 24.10 9.95 118 422516 25055 50157435
Disability 24.08 9.95 186 422448 12589 50169901
Panic attack 23.95 9.95 82 422552 19260 50163230
Depressed mood 23.86 9.95 176 422458 33847 50148643
Eosinophilia 23.83 9.95 78 422556 18574 50163916
Thrombotic microangiopathy 23.73 9.95 23 422611 8768 50173722
Weight increased 23.70 9.95 1976 420658 199915 49982575
Smear cervix abnormal 23.67 9.95 63 422571 2678 50179812
Uterine perforation 23.62 9.95 12 422622 6403 50176087
Blood calcium decreased 23.51 9.95 91 422543 20615 50161875
Heart rate decreased 23.48 9.95 432 422202 36065 50146425
Lethargy 23.37 9.95 282 422352 49150 50133340
Dysgeusia 23.31 9.95 210 422424 38706 50143784
Pancytopenia 23.29 9.95 890 421744 83140 50099350
Skin papilloma 23.24 9.95 83 422551 4146 50178344
Inflammation 23.13 9.95 631 422003 56281 50126209
Blood pressure diastolic increased 23.11 9.95 123 422511 7320 50175170
Cholecystitis chronic 23.10 9.95 28 422606 9641 50172849
Cytomegalovirus infection 23.03 9.95 75 422559 17887 50164603
Wheelchair user 22.71 9.95 92 422542 4880 50177610
Pulmonary arterial hypertension 22.63 9.95 90 422544 20229 50162261
Brain oedema 22.62 9.95 43 422591 12327 50170163
Intentional product use issue 22.60 9.95 820 421814 76098 50106392
Joint stiffness 22.48 9.95 367 422267 29941 50152549
Dysphagia 22.36 9.95 485 422149 77033 50105457
Hemiparesis 22.20 9.95 89 422545 19959 50162531
Macular degeneration 22.19 9.95 55 422579 14333 50168157
Hyperkalaemia 22.11 9.95 276 422358 47813 50134677
Laryngitis 22.05 9.95 162 422472 10794 50171696
Dysmorphism 22.05 9.95 53 422581 2114 50180376
Back pain 22.04 9.95 1561 421073 218469 49964021
Wheezing 21.93 9.95 375 422259 61672 50120818
Deep vein thrombosis 21.91 9.95 456 422178 72848 50109642
Incorrect route of product administration 21.87 9.95 81 422553 18585 50163905
Pancreatitis 21.75 9.95 239 422395 42375 50140115
Drug tolerance decreased 21.72 9.95 141 422493 9019 50173471
Akathisia 21.67 9.95 22 422612 8207 50174283
Infusion site pain 21.64 9.95 44 422590 12302 50170188
Injection site bruising 21.54 9.95 429 422205 36339 50146151
Visual impairment 21.52 9.95 421 422213 67854 50114636
Cardiogenic shock 21.51 9.95 63 422571 15536 50166954
Herpes zoster 21.38 9.95 757 421877 70029 50112461
Dystonia 21.34 9.95 42 422592 11884 50170606
Haemoglobin decreased 21.32 9.95 1282 421352 125934 50056556
Anhedonia 21.28 9.95 29 422605 9495 50172995
Complication associated with device 21.08 9.95 58 422576 14597 50167893
COVID-19 21.01 9.95 269 422365 46393 50136097
Rash erythematous 20.90 9.95 188 422446 34664 50147826
Synovial cyst 20.79 9.95 128 422506 8038 50174452
Venoocclusive liver disease 20.78 9.95 5 422629 4256 50178234
Developmental hip dysplasia 20.65 9.95 38 422596 1253 50181237
Joint range of motion decreased 20.60 9.95 241 422393 18271 50164219
Exposure to toxic agent 20.59 9.95 3 422631 3655 50178835
Tenosynovitis 20.57 9.95 155 422479 10410 50172080
Paradoxical drug reaction 20.51 9.95 3 422631 3644 50178846
Disease recurrence 20.48 9.95 92 422542 19989 50162501
International normalised ratio increased 20.47 9.95 246 422388 42906 50139584
Post transplant lymphoproliferative disorder 20.37 9.95 5 422629 4199 50178291
Interstitial lung disease 20.33 9.95 585 422049 52591 50129899
Ventricular tachycardia 20.32 9.95 66 422568 15755 50166735
Skin exfoliation 20.30 9.95 181 422453 33431 50149059
Placental disorder 20.29 9.95 40 422594 1390 50181100
Hypertransaminasaemia 20.24 9.95 3 422631 3608 50178882
Acute respiratory failure 20.13 9.95 149 422485 28633 50153857
Psychomotor hyperactivity 20.11 9.95 29 422605 9272 50173218
Spinal stenosis 20.10 9.95 187 422447 13363 50169127
Infusion site erythema 20.09 9.95 26 422608 8701 50173789
Neuroleptic malignant syndrome 20.08 9.95 39 422595 11091 50171399
Arthritis infective 20.08 9.95 96 422538 5473 50177017
Synovial fluid analysis 19.93 9.95 43 422591 1595 50180895
Musculoskeletal pain 19.89 9.95 764 421870 71413 50111077
Haematocrit decreased 19.79 9.95 406 422228 34570 50147920
Rotator cuff repair 19.69 9.95 44 422590 1672 50180818
Aggression 19.63 9.95 100 422534 21016 50161474
Agranulocytosis 19.60 9.95 102 422532 21319 50161171
Labelled drug-drug interaction medication error 19.53 9.95 36 422598 10441 50172049
Neck mass 19.36 9.95 67 422567 3294 50179196
Pancreatitis acute 19.29 9.95 118 422516 23694 50158796
Mania 19.05 9.95 39 422595 10877 50171613
Ventricular fibrillation 19.05 9.95 37 422597 10522 50171968
Polyhydramnios 18.99 9.95 48 422586 1977 50180513
Lip swelling 18.79 9.95 125 422509 24611 50157879
Mood altered 18.79 9.95 50 422584 12723 50169767
Liver disorder 18.79 9.95 425 422209 36797 50145693
Second primary malignancy 18.76 9.95 18 422616 6896 50175594
Asphyxia 18.75 9.95 11 422623 5416 50177074
Paralysis 18.74 9.95 27 422607 8637 50173853
Loose body in joint 18.73 9.95 35 422599 1168 50181322
Muscle twitching 18.71 9.95 66 422568 15365 50167125
Paraesthesia 18.69 9.95 817 421817 119426 50063064
Affective disorder 18.62 9.95 10 422624 5171 50177319
Acute graft versus host disease 18.61 9.95 5 422629 3953 50178537
Malignant melanoma 18.41 9.95 146 422488 9962 50172528
Transplant rejection 17.93 9.95 33 422601 9576 50172914
Gestational hypertension 17.82 9.95 49 422585 2124 50180366
Swollen tongue 17.81 9.95 153 422481 28477 50154013
Fracture 17.79 9.95 217 422417 16616 50165874
Hepatic cytolysis 17.78 9.95 25 422609 8078 50174412
Blood creatine phosphokinase increased 17.73 9.95 138 422496 26229 50156261
Joint dislocation 17.69 9.95 169 422465 12164 50170326
Pathogen resistance 17.67 9.95 13 422621 5676 50176814
Abdominal pain upper 17.49 9.95 1121 421513 158188 50024302
Tardive dyskinesia 17.47 9.95 21 422613 7258 50175232
Jaundice 17.45 9.95 139 422495 26290 50156200
Postoperative wound infection 17.45 9.95 126 422508 8349 50174141
Tachypnoea 17.24 9.95 63 422571 14514 50167976
Status epilepticus 17.17 9.95 56 422578 13350 50169140
Abdominal distension 16.96 9.95 471 422163 72432 50110058
Infusion site swelling 16.91 9.95 21 422613 7155 50175335
Product prescribing error 16.91 9.95 104 422530 20857 50161633
Acute chest syndrome 16.90 9.95 24 422610 633 50181857
Myoclonus 16.81 9.95 63 422571 14407 50168083
Anaemia 16.74 9.95 1849 420785 250607 49931883
Hyperlipidaemia 16.73 9.95 82 422552 17408 50165082
Complication of device removal 16.56 9.95 7 422627 4157 50178333
Dyskinesia 16.40 9.95 151 422483 27710 50154780
Congenital arterial malformation 16.39 9.95 17 422617 320 50182170
Foetal anticonvulsant syndrome 16.38 9.95 22 422612 550 50181940
Cholinergic syndrome 16.34 9.95 18 422616 364 50182126
Threatened labour 16.33 9.95 26 422608 761 50181729
Face oedema 16.29 9.95 85 422549 17754 50164736
Bradypnoea 16.23 9.95 3 422631 3071 50179419
Breast feeding 16.22 9.95 27 422607 821 50181669
Muscular weakness 16.16 9.95 639 421995 94374 50088116
Hepatic function abnormal 16.14 9.95 372 422262 32309 50150181
Aphasia 16.10 9.95 156 422478 28338 50154152
Atrial fibrillation 16.08 9.95 690 421944 101055 50081435
Chills 16.07 9.95 652 421982 96035 50086455
Food allergy 16.04 9.95 27 422607 8110 50174380
Product complaint 16.04 9.95 46 422588 11420 50171070
Body height below normal 16.03 9.95 44 422590 1905 50180585
Abdominal pain 15.94 9.95 1728 420906 234500 49947990
Body temperature decreased 15.90 9.95 208 422426 16187 50166303
Atrial septal defect 15.90 9.95 99 422535 6242 50176248
Toxic skin eruption 15.84 9.95 45 422589 11206 50171284
Oropharyngeal pain 15.78 9.95 798 421836 77003 50105487
Unevaluable event 15.77 9.95 280 422354 45786 50136704
Therapeutic response decreased 15.75 9.95 511 422123 46720 50135770
Renal injury 15.69 9.95 30 422604 8581 50173909
Blood iron increased 15.61 9.95 35 422599 1333 50181157
Anger 15.46 9.95 46 422588 11287 50171203
Temperature regulation disorder 15.43 9.95 8 422626 4219 50178271
Oral herpes 15.38 9.95 251 422383 20474 50162016
Nervousness 15.37 9.95 152 422482 27499 50154991
Miosis 15.36 9.95 18 422616 6292 50176198
Silent thyroiditis 15.28 9.95 9 422625 69 50182421
Gastroenteritis viral 15.26 9.95 231 422403 18555 50163935
Crohn's disease 15.23 9.95 79 422555 4654 50177836
Catheter site erythema 15.22 9.95 7 422627 3955 50178535
Haematoma 15.22 9.95 172 422462 30338 50152152
Product substitution issue 15.19 9.95 63 422571 13994 50168496
Visual acuity reduced 15.18 9.95 102 422532 20037 50162453
Clear cell renal cell carcinoma 15.12 9.95 32 422602 1171 50181319
Oedema peripheral 15.10 9.95 1125 421509 156836 50025654
Rebound effect 15.05 9.95 4 422630 3185 50179305
Occult blood 15.05 9.95 32 422602 1175 50181315
Synovial disorder 15.04 9.95 27 422607 873 50181617
Rash maculo-papular 14.99 9.95 146 422488 26495 50155995
Cushingoid 14.98 9.95 101 422533 6544 50175946
Ketoacidosis 14.78 9.95 7 422627 3888 50178602
Body temperature increased 14.74 9.95 179 422455 31162 50151328
Hypokalaemia 14.70 9.95 593 422041 87399 50095091
Coronary artery disease 14.66 9.95 168 422466 29558 50152932
Personality disorder 14.61 9.95 9 422625 4315 50178175
Graft versus host disease 14.58 9.95 18 422616 6148 50176342
Red blood cell sedimentation rate 14.55 9.95 64 422570 3522 50178968
Joint noise 14.54 9.95 64 422570 3523 50178967
Trigeminal neuralgia 14.53 9.95 4 422630 3111 50179379
Toxic epidermal necrolysis 14.52 9.95 109 422525 20883 50161607
Haemorrhage in pregnancy 14.48 9.95 39 422595 1670 50180820
Pregnancy with contraceptive device 14.48 9.95 8 422626 4071 50178419
Pulmonary oedema 14.45 9.95 305 422329 48633 50133857
Lung neoplasm malignant 14.42 9.95 195 422439 15289 50167201
Cellulitis 14.32 9.95 726 421908 70072 50112418
Dactylitis 14.31 9.95 41 422593 1820 50180670
Sinus tachycardia 14.24 9.95 112 422522 21242 50161248
Maternal exposure timing unspecified 14.23 9.95 64 422570 3556 50178934
Inappropriate antidiuretic hormone secretion 14.14 9.95 59 422575 13084 50169406
Metastases to lung 14.14 9.95 46 422588 10974 50171516
Cyanosis 14.06 9.95 72 422562 15112 50167378
Myopathy 14.04 9.95 35 422599 9104 50173386
Hot flush 14.02 9.95 272 422362 43897 50138593
Antinuclear antibody positive 13.94 9.95 95 422539 6177 50176313
Renal impairment 13.94 9.95 504 422130 75157 50107333
Exomphalos 13.93 9.95 20 422614 533 50181957
Ear pain 13.89 9.95 160 422474 28123 50154367
Hereditary angioedema 13.82 9.95 15 422619 5427 50177063
Talipes 13.76 9.95 34 422600 1380 50181110
Catatonia 13.74 9.95 7 422627 3729 50178761
Foetal death 13.73 9.95 116 422518 8064 50174426
Joint injury 13.70 9.95 257 422377 21532 50160958
Fracture delayed union 13.66 9.95 46 422588 2230 50180260
Infusion site pruritus 13.57 9.95 8 422626 3929 50178561
Acute coronary syndrome 13.56 9.95 37 422597 9337 50173153
Mental disorder 13.46 9.95 118 422516 21873 50160617
Scleritis 13.41 9.95 58 422576 3169 50179321
Multiple allergies 13.32 9.95 32 422602 8431 50174059
Angina pectoris 13.31 9.95 147 422487 26041 50156449
Haemophagocytic lymphohistiocytosis 13.31 9.95 33 422601 8600 50173890
Schizophrenia 13.28 9.95 26 422608 7371 50175119
Progressive multifocal leukoencephalopathy 13.24 9.95 50 422584 11407 50171083
Cardiotoxicity 13.23 9.95 24 422610 7003 50175487
Upper respiratory tract inflammation 13.22 9.95 47 422587 2342 50180148
Pulseless electrical activity 13.21 9.95 23 422611 6818 50175672
Surgery 13.16 9.95 338 422296 29867 50152623
Non-small cell lung cancer 13.14 9.95 54 422580 2883 50179607
Red blood cell count decreased 13.14 9.95 373 422261 33462 50149028
Lupus-like syndrome 13.09 9.95 129 422505 9362 50173128
Gastroenteritis 13.09 9.95 270 422364 23011 50159479
Injection site warmth 13.06 9.95 175 422459 13691 50168799
Respiration abnormal 13.03 9.95 14 422620 5088 50177402
Dehydration 12.98 9.95 1096 421538 151353 50031137
Cholestasis of pregnancy 12.98 9.95 29 422605 1102 50181388
Urinary incontinence 12.93 9.95 162 422472 28046 50154444
Device breakage 12.85 9.95 39 422595 9508 50172982
Abortion incomplete 12.84 9.95 5 422629 3121 50179369
Cardiomyopathy 12.75 9.95 77 422557 15509 50166981
Fear of injection 12.72 9.95 91 422543 6012 50176478
Human antichimeric antibody positive 12.63 9.95 34 422600 1455 50181035
Joint lock 12.63 9.95 42 422592 2023 50180467
Cystitis 12.58 9.95 473 422161 44091 50138399
Speech disorder developmental 12.57 9.95 20 422614 585 50181905
Multiple sclerosis 12.53 9.95 110 422524 20383 50162107
Drug abuser 12.52 9.95 4 422630 2824 50179666
Colitis microscopic 12.52 9.95 22 422612 6498 50175992
Multiple-drug resistance 12.51 9.95 6 422628 3308 50179182
Dislocation of vertebra 12.46 9.95 55 422579 3032 50179458
Antibody test positive 12.40 9.95 45 422589 2266 50180224
Circulatory collapse 12.38 9.95 107 422527 19893 50162597
Sexual dysfunction 12.36 9.95 6 422628 3286 50179204
Arthritis bacterial 12.36 9.95 85 422549 5544 50176946
Hepatitis cholestatic 12.33 9.95 20 422614 6097 50176393
Product preparation error 12.32 9.95 11 422623 4361 50178129
Device issue 12.30 9.95 107 422527 19865 50162625
Induced labour 12.29 9.95 25 422609 889 50181601
Foetal distress syndrome 12.19 9.95 30 422604 1215 50181275
Dermatitis exfoliative 12.17 9.95 15 422619 5127 50177363
Gamma-glutamyltransferase increased 12.17 9.95 174 422460 29449 50153041
Cerebral haemorrhage 12.16 9.95 156 422478 26896 50155594
Skin cancer 12.15 9.95 126 422508 9268 50173222
Abnormal dreams 12.13 9.95 39 422595 9338 50173152
Cardiac disorder 12.07 9.95 270 422364 42709 50139781
Paranoia 12.06 9.95 45 422589 10303 50172187
Neonatal respiratory distress syndrome 12.04 9.95 49 422585 2605 50179885
Stillbirth 11.97 9.95 88 422546 5864 50176626
Lymphatic fistula 11.90 9.95 22 422612 728 50181762
Hypertelorism 11.88 9.95 16 422618 401 50182089
Throat tightness 11.84 9.95 114 422520 20733 50161757
Transplant dysfunction 11.80 9.95 13 422621 4671 50177819
Immunosuppression 11.78 9.95 104 422530 7322 50175168
Leukocytosis 11.77 9.95 126 422508 22453 50160037
Wound infection pseudomonas 11.75 9.95 30 422604 1243 50181247
Cytopenia 11.70 9.95 36 422598 8739 50173751
Femoral hernia incarcerated 11.67 9.95 22 422612 739 50181751
Hallucination, auditory 11.64 9.95 48 422586 10680 50171810
Autism spectrum disorder 11.64 9.95 21 422613 682 50181808
Drug screen positive 11.61 9.95 7 422627 3395 50179095
Adverse reaction 11.61 9.95 35 422599 8551 50173939
Lymphoma 11.59 9.95 127 422507 9474 50173016
Acidosis 11.58 9.95 45 422589 10182 50172308
Medication error 11.56 9.95 222 422412 35882 50146608
Sinus bradycardia 11.38 9.95 64 422570 13119 50169371
X-ray gastrointestinal tract abnormal 11.38 9.95 3 422631 0 50182490
Stoma site pruritus 11.38 9.95 3 422631 0 50182490
Corneal opacity congenital 11.38 9.95 3 422631 0 50182490
Aspergillus infection 11.38 9.95 25 422609 6796 50175694
Osteonecrosis of jaw 11.36 9.95 197 422437 32329 50150161
Abortion threatened 11.35 9.95 18 422616 525 50181965
Renal tubular necrosis 11.34 9.95 45 422589 10123 50172367
Ataxia 11.33 9.95 68 422566 13718 50168772
Acute myocardial infarction 11.31 9.95 174 422460 29099 50153391
Wrong product administered 11.31 9.95 17 422617 5343 50177147
Parkinsonism 11.30 9.95 37 422597 8810 50173680
Bone lesion 11.30 9.95 16 422618 5154 50177336
Cervical incompetence 11.29 9.95 19 422615 583 50181907
Muscle rigidity 11.29 9.95 43 422591 9786 50172704
Abortion missed 11.27 9.95 34 422600 1554 50180936
Coronary arterial stent insertion 11.18 9.95 4 422630 2630 50179860
Anuria 11.17 9.95 52 422582 11192 50171298
Immunodeficiency 11.16 9.95 180 422454 14648 50167842
Product administered to patient of inappropriate age 11.15 9.95 4 422630 2626 50179864
Dry skin 11.11 9.95 275 422359 42916 50139574
Device related infection 11.10 9.95 115 422519 20620 50161870
Bundle branch block left 11.09 9.95 22 422612 6208 50176282
Serum ferritin increased 11.09 9.95 78 422556 5124 50177366
Hallucination, visual 11.05 9.95 87 422547 16495 50165995
Genital haemorrhage 11.04 9.95 24 422610 6550 50175940
Ascites 11.03 9.95 222 422412 35639 50146851
Pseudomonas infection 10.99 9.95 41 422593 9389 50173101
Human herpesvirus 6 infection 10.99 9.95 4 422630 2602 50179888
Influenza like illness 10.98 9.95 381 422253 57078 50125412
Atrioventricular block complete 10.98 9.95 28 422606 7227 50175263
Embedded device 10.92 9.95 5 422629 2832 50179658
Pharyngitis streptococcal 10.86 9.95 117 422517 8691 50173799
Renal mass 10.85 9.95 38 422596 1880 50180610
Malignant mediastinal neoplasm 10.84 9.95 18 422616 546 50181944
Device deployment issue 10.84 9.95 8 422626 3488 50179002
Injection site haematoma 10.74 9.95 87 422547 5973 50176517
Sleep disorder due to a general medical condition 10.73 9.95 29 422605 7342 50175148
Human anti-human antibody test 10.73 9.95 15 422619 390 50182100
Pneumonia viral 10.63 9.95 26 422608 6808 50175682
Atrioventricular block 10.60 9.95 24 422610 6454 50176036
Acute myeloid leukaemia 10.56 9.95 78 422556 14996 50167494
Pulmonary hypertension 10.54 9.95 206 422428 33211 50149279
Tubulointerstitial nephritis 10.51 9.95 79 422555 15132 50167358
Clostridium difficile colitis 10.51 9.95 96 422538 17646 50164844
Wound infection 10.51 9.95 151 422483 11997 50170493
Intracranial pressure increased 10.49 9.95 12 422622 4240 50178250
Lymphoedema 10.41 9.95 40 422594 9082 50173408
Incorrect product administration duration 10.38 9.95 41 422593 9234 50173256
Rectal haemorrhage 10.33 9.95 244 422390 38314 50144176
Poor quality sleep 10.33 9.95 89 422545 16557 50165933
Restless legs syndrome 10.32 9.95 84 422550 15813 50166677
Electrocardiogram QRS complex prolonged 10.29 9.95 18 422616 5326 50177164
Potentiating drug interaction 10.28 9.95 10 422624 3806 50178684
Catheter management 10.27 9.95 5 422629 2734 50179756
Melaena 10.27 9.95 160 422474 26704 50155786
Anterior chamber cleavage syndrome 10.27 9.95 10 422624 174 50182316
Joint warmth 10.24 9.95 30 422604 1349 50181141
Haemorrhage intracranial 10.19 9.95 61 422573 12313 50170177
Application site pain 10.18 9.95 10 422624 3788 50178702
Respiratory acidosis 10.13 9.95 22 422612 6006 50176484
Ileus 10.11 9.95 161 422473 13068 50169422
Amnesia 10.09 9.95 272 422362 41988 50140502
Stress cardiomyopathy 10.06 9.95 33 422601 7854 50174636
Oliguria 10.06 9.95 35 422599 8181 50174309
Lung adenocarcinoma 10.03 9.95 64 422570 4070 50178420
Disseminated tuberculosis 10 9.95 45 422589 2501 50179989
Presyncope 9.99 9.95 142 422492 24056 50158434
Schizoaffective disorder 9.98 9.95 3 422631 2203 50180287
Drug eruption 9.95 9.95 263 422371 23343 50159147

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 404.94 10.07 16 175682 79867 29318962
Rheumatoid arthritis 396.98 10.07 697 175001 31455 29367374
Toxicity to various agents 342.08 10.07 317 175381 173344 29225485
Completed suicide 279.03 10.07 94 175604 90152 29308677
Foetal exposure during pregnancy 209.70 10.07 555 175143 33312 29365517
Drug interaction 165.53 10.07 609 175089 196776 29202053
Interstitial lung disease 137.84 10.07 693 175005 57025 29341804
Arthralgia 121.12 10.07 1315 174383 138302 29260527
Psoriatic arthropathy 113.37 10.07 262 175436 14429 29384400
Dysmorphism 107.12 10.07 109 175589 2862 29395967
Intentional overdose 96.99 10.07 54 175644 38474 29360355
Sickle cell anaemia with crisis 92.79 10.07 95 175603 2513 29396316
Overdose 89.33 10.07 215 175483 79604 29319225
Product use in unapproved indication 83.65 10.07 252 175446 86623 29312206
Death 77.86 10.07 1499 174199 340585 29058244
Acute kidney injury 76.80 10.07 1112 174586 264155 29134674
Drug reaction with eosinophilia and systemic symptoms 73.74 10.07 37 175661 27955 29370874
Platelet count decreased 72.62 10.07 945 174753 103727 29295102
Pneumonia 71.35 10.07 2443 173255 317729 29081100
Enthesopathy 68.13 10.07 97 175601 3646 29395183
Premature baby 67.38 10.07 241 175457 17039 29381790
Drug resistance 65.52 10.07 23 175675 21517 29377312
Speech disorder developmental 63.42 10.07 67 175631 1840 29396989
Exposure during pregnancy 59.99 10.07 147 175551 8407 29390422
Off label use 58.68 10.07 1351 174347 299449 29099380
Neonatal respiratory distress syndrome 56.88 10.07 90 175608 3720 29395109
Tenosynovitis 56.86 10.07 89 175609 3644 29395185
Coma 55.47 10.07 93 175605 39357 29359472
Joint swelling 54.87 10.07 492 175206 49138 29349691
Drug dependence 54.86 10.07 28 175670 20953 29377876
Foetal anticonvulsant syndrome 53.87 10.07 49 175649 1115 29397714
Suicide attempt 53.14 10.07 75 175623 34035 29364794
Psoriasis 50.87 10.07 347 175351 31880 29366949
C-reactive protein increased 50.59 10.07 442 175256 43821 29355008
Hypospadias 50.57 10.07 75 175623 2927 29395902
Atrial septal defect 50.10 10.07 119 175579 6670 29392159
Haemoglobin decreased 48.20 10.07 908 174790 107467 29291362
Nasopharyngitis 47.08 10.07 552 175146 59113 29339716
Intentional product misuse 46.64 10.07 84 175614 34577 29364252
Hypermagnesaemia 45.49 10.07 23 175675 185 29398644
Blood pressure fluctuation 45.44 10.07 236 175462 19658 29379171
Autism spectrum disorder 45.11 10.07 58 175640 1974 29396855
Angioedema 44.16 10.07 76 175622 31839 29366990
Maternal exposure during pregnancy 44.02 10.07 84 175614 4039 29394790
Maternal drugs affecting foetus 43.66 10.07 81 175617 3812 29395017
Low birth weight baby 42.61 10.07 110 175588 6498 29392331
Suicidal ideation 42.49 10.07 89 175609 34627 29364202
Neutrophil count decreased 42.22 10.07 420 175278 43147 29355682
Learning disorder 41.49 10.07 40 175658 982 29397847
Drug withdrawal syndrome 40.04 10.07 29 175669 17955 29380874
Hypoglycaemia neonatal 39.52 10.07 50 175648 1674 29397155
Cryptorchism 39.35 10.07 53 175645 1889 29396940
Hepatic function abnormal 39.28 10.07 381 175317 38878 29359951
Musculoskeletal stiffness 39.20 10.07 367 175331 37091 29361738
Maternal exposure during breast feeding 38.76 10.07 46 175652 1440 29397389
Lactic acidosis 38.32 10.07 76 175622 30171 29368658
Small for dates baby 38.32 10.07 73 175625 3506 29395323
Synovitis 36.73 10.07 145 175553 10745 29388084
Psychotic disorder 36.69 10.07 40 175658 20314 29378515
Non-small cell lung cancer 35.94 10.07 64 175634 2917 29395912
Tongue disorder 35.01 10.07 82 175616 4554 29394275
C-reactive protein abnormal 34.39 10.07 101 175597 6435 29392394
Pancytopenia 33.98 10.07 688 175010 82480 29316349
Urticaria 33.49 10.07 189 175509 54471 29344358
Agitation 33.30 10.07 174 175524 51130 29347699
Ventricular septal defect 32.98 10.07 68 175630 3461 29395368
Sedation 32.73 10.07 33 175665 17372 29381457
Syndactyly 32.72 10.07 31 175667 744 29398085
Foot deformity 32.52 10.07 73 175625 3942 29394887
Pathogen resistance 31.89 10.07 5 175693 8111 29390718
Lung neoplasm malignant 31.88 10.07 169 175529 14188 29384641
Poisoning 31.56 10.07 10 175688 9983 29388846
Arthritis 30.24 10.07 253 175445 24766 29374063
Drug ineffective 30.15 10.07 1809 173889 361361 29037468
Respiratory arrest 30.14 10.07 68 175630 25765 29373064
Serum ferritin increased 30.02 10.07 87 175611 5501 29393328
Serotonin syndrome 29.85 10.07 36 175662 17476 29381353
Renal failure 29.54 10.07 511 175187 118088 29280741
Joint laxity 29.54 10.07 22 175676 374 29398455
Bradycardia 29.29 10.07 249 175449 65380 29333449
Blood lactate dehydrogenase increased 29.23 10.07 205 175493 19004 29379825
Exposure via breast milk 29.17 10.07 43 175655 1669 29397160
Rheumatoid nodule 28.79 10.07 48 175650 2074 29396755
Pulmonary fibrosis 28.40 10.07 174 175524 15408 29383421
Congenital hand malformation 27.95 10.07 25 175673 556 29398273
Developmental delay 27.75 10.07 52 175646 2466 29396363
Alanine aminotransferase abnormal 27.66 10.07 57 175641 2900 29395929
Substance abuse 27.08 10.07 4 175694 6783 29392046
Rhabdomyolysis 27.01 10.07 231 175467 60577 29338252
Hypermobility syndrome 26.95 10.07 20 175678 338 29398491
Basal cell carcinoma 26.63 10.07 182 175516 16728 29382101
Jaundice neonatal 26.56 10.07 35 175663 1221 29397608
White blood cell count decreased 26.33 10.07 665 175033 82697 29316132
Intellectual disability 26.10 10.07 33 175665 1104 29397725
Cardiac arrest 25.64 10.07 356 175342 85235 29313594
Talipes 24.93 10.07 41 175657 1751 29397078
Confusional state 24.91 10.07 574 175124 127303 29271526
Pain 24.89 10.07 1251 174447 170181 29228648
Osteoarthritis 24.01 10.07 187 175511 17916 29380913
Haematocrit decreased 23.99 10.07 271 175427 28751 29370078
Cerebral infarction 23.96 10.07 238 175460 24437 29374392
Language disorder 23.54 10.07 42 175656 1917 29396912
Acute hepatic failure 23.23 10.07 22 175676 11930 29386899
Blood pressure systolic abnormal 23.04 10.07 44 175654 2117 29396712
Plagiocephaly 22.97 10.07 21 175677 481 29398348
Multiple organ dysfunction syndrome 22.86 10.07 252 175446 62864 29335965
Cancer pain 22.85 10.07 46 175652 2301 29396528
Immune reconstitution inflammatory syndrome 22.60 10.07 9 175689 7793 29391036
Red blood cell count decreased 22.51 10.07 242 175456 25360 29373469
Drug ineffective for unapproved indication 22.39 10.07 31 175667 14183 29384646
Large for dates baby 22.39 10.07 27 175671 860 29397969
Aggression 22.25 10.07 122 175576 35419 29363410
Infective pulmonary exacerbation of cystic fibrosis 22.04 10.07 5 175693 6231 29392598
Pneumonia aspiration 21.90 10.07 323 175375 36414 29362415
Intentional self-injury 21.90 10.07 25 175673 12436 29386393
Blood pressure systolic increased 21.79 10.07 173 175525 16672 29382157
Hepatocellular injury 21.60 10.07 60 175638 21183 29377646
Arthropathy 21.46 10.07 209 175489 21345 29377484
Tendonitis 21.44 10.07 99 175599 7862 29390967
Somnolence 21.13 10.07 412 175286 93543 29305286
Hyperbilirubinaemia neonatal 21.08 10.07 24 175674 718 29398111
Knee deformity 20.99 10.07 21 175677 540 29398289
Infusion related reaction 20.98 10.07 372 175326 43514 29355315
Polyarthritis 20.79 10.07 61 175637 3884 29394945
Foetal growth restriction 20.59 10.07 59 175639 3707 29395122
Depression 20.50 10.07 369 175329 84778 29314051
Joint effusion 20.45 10.07 63 175635 4121 29394708
Toxic epidermal necrolysis 20.20 10.07 49 175649 18104 29380725
Hydrocele 19.89 10.07 39 175659 1914 29396915
Motor developmental delay 19.87 10.07 22 175676 638 29398191
Otitis media 19.78 10.07 46 175652 2543 29396286
Radiation pneumonitis 19.72 10.07 42 175656 2187 29396642
Progressive multifocal leukoencephalopathy 19.49 10.07 14 175684 8705 29390124
Cholestasis 19.18 10.07 73 175625 23389 29375440
Strabismus 19.17 10.07 32 175666 1384 29397445
Selective eating disorder 19.15 10.07 35 175663 1628 29397201
Tachycardia 18.99 10.07 309 175389 72101 29326728
Astigmatism 18.81 10.07 26 175672 950 29397879
Dysgraphia 18.73 10.07 39 175659 1999 29396830
Hand deformity 18.69 10.07 40 175658 2090 29396739
Gastric cancer 17.95 10.07 66 175632 4728 29394101
Caesarean section 17.91 10.07 37 175661 1886 29396943
Limb reduction defect 17.75 10.07 14 175684 260 29398569
Cellulitis 17.65 10.07 376 175322 45464 29353365
Irritability 17.42 10.07 70 175628 22082 29376747
Dyslexia 17.41 10.07 15 175683 317 29398512
Diabetic ketoacidosis 17.40 10.07 44 175654 16029 29382800
No adverse event 17.30 10.07 50 175648 17428 29381401
Blood pressure diastolic decreased 17.22 10.07 85 175613 6937 29391892
Disseminated intravascular coagulation 17.17 10.07 188 175510 19792 29379037
Medical device implantation 17.02 10.07 19 175679 556 29398273
Skin cancer 17 10.07 97 175601 8371 29390458
Knee arthroplasty 16.96 10.07 74 175624 5735 29393094
Dyspraxia 16.86 10.07 16 175682 385 29398444
Product quality issue 16.84 10.07 44 175654 15851 29382978
Myalgia 16.82 10.07 324 175374 73695 29325134
Hypotonia neonatal 16.77 10.07 28 175670 1211 29397618
Rash maculo-papular 16.54 10.07 81 175617 24208 29374621
Malignant neoplasm progression 16.42 10.07 564 175134 73295 29325534
Sexual dysfunction 16.37 10.07 7 175691 5807 29393022
Crohn's disease 16.31 10.07 47 175651 2962 29395867
Prostate cancer 16.23 10.07 227 175471 25300 29373529
Upper respiratory tract inflammation 16.07 10.07 32 175666 1588 29397241
Anal fistula 15.92 10.07 58 175640 4137 29394692
Unresponsive to stimuli 15.86 10.07 86 175612 25040 29373789
Agitation neonatal 15.84 10.07 25 175673 1031 29397798
Lacrimal disorder 15.74 10.07 14 175684 309 29398520
Congenital bladder anomaly 15.68 10.07 13 175685 260 29398569
Cleft lip 15.63 10.07 14 175684 312 29398517
Hallucination 15.60 10.07 180 175518 44532 29354297
Drug withdrawal syndrome neonatal 15.57 10.07 50 175648 3345 29395484
Behaviour disorder 15.45 10.07 52 175646 3564 29395265
Metabolic acidosis 15.44 10.07 146 175552 37516 29361313
Weight decrease neonatal 15.37 10.07 14 175684 319 29398510
Foetal disorder 15.31 10.07 21 175677 762 29398067
Electrocardiogram QRS complex prolonged 15.13 10.07 3 175695 4107 29394722
Arthritis bacterial 15.08 10.07 59 175639 4354 29394475
Inguinal hernia 15.03 10.07 79 175619 6609 29392220
Hypotension 15.02 10.07 974 174724 193380 29205449
Malignant melanoma 15.02 10.07 83 175615 7078 29391751
Lower respiratory tract infection 15.01 10.07 231 175467 26271 29372558
Congenital foot malformation 14.98 10.07 15 175683 386 29398443
Blood pressure diastolic abnormal 14.96 10.07 41 175657 2510 29396319
Bronchiolitis 14.90 10.07 43 175655 2712 29396117
Immunodeficiency 14.88 10.07 59 175639 4381 29394448
Adenovirus infection 14.87 10.07 4 175694 4443 29394386
Renal aplasia 14.77 10.07 19 175679 647 29398182
Ankyloglossia congenital 14.73 10.07 13 175685 284 29398545
Neuroleptic malignant syndrome 14.70 10.07 48 175650 16100 29382729
Suspected suicide 14.66 10.07 3 175695 4017 29394812
Liver disorder 14.64 10.07 239 175459 27510 29371319
Scoliosis 14.53 10.07 38 175660 2262 29396567
Ileus 14.51 10.07 140 175558 14262 29384567
Microcephaly 14.49 10.07 20 175678 730 29398099
Drug intolerance 14.40 10.07 383 175315 47996 29350833
Juvenile idiopathic arthritis 14.39 10.07 28 175670 1366 29397463
Diaphragmatic disorder 14.39 10.07 23 175675 959 29397870
Blood pressure increased 14.31 10.07 555 175143 73248 29325581
Colon cancer 14.28 10.07 86 175612 7569 29391260
Iron overload 14.19 10.07 25 175673 1130 29397699
Enteritis infectious 14.17 10.07 26 175672 1213 29397616
Congenital anomaly 14.11 10.07 27 175671 1301 29397528
Transaminases increased 14.07 10.07 78 175620 22584 29376245
Electrocardiogram QT prolonged 14.01 10.07 142 175556 35995 29362834
Haemangioma 13.94 10.07 31 175667 1663 29397166
Haemangioma congenital 13.94 10.07 16 175682 483 29398346
Incorrect route of product administration 13.80 10.07 27 175671 10774 29388055
Hepatitis 13.75 10.07 70 175628 20713 29378116
Wrong technique in product usage process 13.68 10.07 120 175578 31308 29367521
Cardiogenic shock 13.65 10.07 63 175635 19127 29379702
Vitamin D deficiency 13.61 10.07 67 175631 5462 29393367
Pectus excavatum 13.61 10.07 11 175687 212 29398617
Withdrawal syndrome 13.60 10.07 28 175670 10964 29387865
Erectile dysfunction 13.48 10.07 58 175640 17951 29380878
Renal injury 13.47 10.07 25 175673 10177 29388652
Grip strength decreased 13.45 10.07 37 175661 2270 29396559
Second primary malignancy 13.44 10.07 12 175686 6693 29392136
Post transplant lymphoproliferative disorder 13.39 10.07 8 175690 5485 29393344
Attention deficit hyperactivity disorder 13.37 10.07 36 175662 2181 29396648
Peripheral artery thrombosis 13.35 10.07 35 175663 2087 29396742
Arthrodesis 13.33 10.07 15 175683 443 29398386
Multiple congenital abnormalities 13.31 10.07 16 175682 508 29398321
Lymphangiosis carcinomatosa 13.27 10.07 20 175678 792 29398037
Neck mass 13.21 10.07 28 175670 1453 29397376
Blood pressure diastolic increased 13.18 10.07 50 175648 3636 29395193
Polydactyly 13.14 10.07 24 175674 1116 29397713
Oesophageal fibrosis 13.13 10.07 10 175688 176 29398653
Meningeal disorder 13.13 10.07 13 175685 330 29398499
Back disorder 13.05 10.07 70 175628 5903 29392926
Vascular insufficiency 13.03 10.07 13 175685 333 29398496
Infection 13.01 10.07 569 175129 76182 29322647
Body temperature decreased 12.97 10.07 108 175590 10556 29388273
Neurotoxicity 12.92 10.07 44 175654 14569 29384260
Pleural fibrosis 12.80 10.07 26 175672 1309 29397520
Nephropathy toxic 12.80 10.07 28 175670 10728 29388101
Post procedural infection 12.69 10.07 55 175643 4250 29394579
Septic arthritis staphylococcal 12.68 10.07 15 175683 468 29398361
Myocardial infarction 12.65 10.07 531 175167 109765 29289064
Musculoskeletal pain 12.64 10.07 242 175456 28711 29370118
Blood insulin increased 12.63 10.07 13 175685 346 29398483
Medication error 12.63 10.07 74 175624 21137 29377692
Alcohol abuse 12.55 10.07 5 175693 4328 29394501
Hypertransaminasaemia 12.53 10.07 3 175695 3603 29395226
Wound 12.52 10.07 118 175580 11945 29386884
Patent ductus arteriosus 12.49 10.07 44 175654 3087 29395742
Hypertelorism 12.48 10.07 16 175682 543 29398286
Nasal disorder 12.47 10.07 27 175671 1422 29397407
Coronary artery disease 12.45 10.07 186 175512 44004 29354825
Bradycardia neonatal 12.40 10.07 21 175677 919 29397910
Peripheral swelling 12.28 10.07 479 175219 63260 29335569
Maternal exposure timing unspecified 12.19 10.07 13 175685 361 29398468
Muscle twitching 12.15 10.07 18 175680 8008 29390821
Pneumonia bacterial 12.11 10.07 96 175602 9247 29389582
Therapy partial responder 12.08 10.07 8 175690 5191 29393638
Pruritus 12.08 10.07 569 175129 116280 29282549
Psychomotor retardation 12.02 10.07 42 175656 2934 29395895
Venoocclusive liver disease 12.02 10.07 14 175684 6903 29391926
Arnold-Chiari malformation 12.01 10.07 12 175686 308 29398521
Diverticular perforation 11.96 10.07 42 175656 2942 29395887
Loss of personal independence in daily activities 11.93 10.07 215 175483 25225 29373604
Hernia pain 11.92 10.07 11 175687 255 29398574
Lip swelling 11.92 10.07 36 175662 12374 29386455
Hyperhidrosis 11.91 10.07 292 175406 64248 29334581
Cytomegalovirus infection 11.79 10.07 85 175613 23130 29375699
Emphysema 11.74 10.07 90 175608 8581 29390248
Spinal compression fracture 11.71 10.07 69 175629 6025 29392804
Respiratory disorder neonatal 11.64 10.07 26 175672 1399 29397430
Agranulocytosis 11.56 10.07 72 175626 20268 29378561
Spinal disorder 11.51 10.07 48 175650 3647 29395182
Hiccups 11.49 10.07 91 175607 8762 29390067
Potentiating drug interaction 11.49 10.07 6 175692 4432 29394397
Cardiotoxicity 11.44 10.07 7 175691 4737 29394092
Tooth malformation 11.42 10.07 9 175689 167 29398662
Ear disorder 11.27 10.07 24 175674 1250 29397579
C-reactive protein decreased 11.24 10.07 27 175671 1524 29397305
Radiation inflammation 11.20 10.07 10 175688 222 29398607
Anal atresia 11.18 10.07 11 175687 277 29398552
Anaemia vitamin B12 deficiency 11.18 10.07 11 175687 277 29398552
Respiratory depression 11.10 10.07 42 175656 13481 29385348
Mechanical ileus 11.05 10.07 11 175687 281 29398548
Developmental coordination disorder 11.02 10.07 9 175689 176 29398653
Folate deficiency 11.01 10.07 22 175676 1095 29397734
Spina bifida 11.00 10.07 12 175686 342 29398487
Foetal heart rate deceleration abnormality 10.92 10.07 14 175684 475 29398354
Nail avulsion 10.82 10.07 4 175694 13 29398816
Blood lactic acid increased 10.76 10.07 11 175687 5755 29393074
Mental impairment 10.71 10.07 24 175674 9117 29389712
Finger deformity 10.69 10.07 22 175676 1118 29397711
Obsessive-compulsive disorder 10.69 10.07 7 175691 4569 29394260
Aspergillus infection 10.67 10.07 30 175668 10551 29388278
Joint range of motion decreased 10.65 10.07 67 175631 5987 29392842
Anxiety 10.64 10.07 407 175291 84958 29313871
Palindromic rheumatism 10.61 10.07 9 175689 186 29398643
Vitamin B12 deficiency 10.59 10.07 43 175655 3228 29395601
Hepatic failure 10.55 10.07 128 175570 31384 29367445
Ear malformation 10.53 10.07 11 175687 298 29398531
Tuberculosis 10.48 10.07 76 175622 7120 29391709
Lung cancer metastatic 10.46 10.07 35 175663 2392 29396437
Cleft palate 10.43 10.07 15 175683 569 29398260
Gangrene neonatal 10.37 10.07 9 175689 192 29398637
Eosinophilia 10.37 10.07 83 175615 22078 29376751
Blood parathyroid hormone decreased 10.33 10.07 18 175680 806 29398023
Adverse drug reaction 10.32 10.07 92 175606 23928 29374901
Pleural effusion 10.25 10.07 524 175174 71384 29327445
Foetal distress syndrome 10.23 10.07 20 175678 979 29397850
Decreased appetite 10.18 10.07 999 174699 144343 29254486
Haematotoxicity 10.16 10.07 15 175683 6684 29392145
Heart rate decreased 10.13 10.07 206 175492 24706 29374123
Small cell lung cancer 10.12 10.07 28 175670 1724 29397105
Appendicolith 10.11 10.07 4 175694 3476 29395353
Blood sodium decreased 10.08 10.07 133 175565 14634 29384195

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 998.96 9.88 189 456247 224225 63818071
Rheumatoid arthritis 983.57 9.88 2972 453464 161322 63880974
Toxicity to various agents 934.31 9.88 724 455712 362789 63679507
Drug abuse 744.05 9.88 49 456387 132325 63909971
Pemphigus 656.45 9.88 1376 455060 59325 63982971
Systemic lupus erythematosus 630.41 9.88 1571 454865 76041 63966255
Arthropathy 609.25 9.88 2063 454373 118904 63923392
Hand deformity 602.42 9.88 1356 455080 61415 63980881
Synovitis 557.47 9.88 1755 454681 97335 63944961
Glossodynia 548.09 9.88 1331 455105 63365 63978931
Joint swelling 539.79 9.88 2973 453463 212409 63829887
Maternal exposure during pregnancy 503.79 9.88 1659 454777 94225 63948071
Infusion related reaction 462.45 9.88 2344 454092 162123 63880173
Arthralgia 458.70 9.88 4963 451473 437297 63604999
Drug interaction 451.78 9.88 1203 455233 360880 63681416
Anti-cyclic citrullinated peptide antibody positive 449.32 9.88 1047 455389 48515 63993781
Wound 434.18 9.88 1359 455077 75118 63967178
Pericarditis 425.56 9.88 1185 455251 61331 63980965
Intentional overdose 340.80 9.88 106 456330 89838 63952458
Abdominal discomfort 336.19 9.88 2326 454110 179996 63862300
Nasopharyngitis 309.24 9.88 2410 454026 193663 63848633
Alopecia 309.09 9.88 2120 454316 163570 63878726
Death 295.68 9.88 2101 454335 480604 63561692
Pain 293.83 9.88 5521 450915 547990 63494306
Discomfort 278.46 9.88 1223 455213 79655 63962641
Swelling 275.48 9.88 2010 454426 158208 63884088
Contraindicated product administered 274.09 9.88 1495 454941 106334 63935962
Rheumatoid factor positive 269.74 9.88 694 455742 34244 64008052
Therapeutic product effect decreased 269.21 9.88 1563 454873 113788 63928508
Duodenal ulcer perforation 259.32 9.88 680 455756 33945 64008351
Helicobacter infection 257.89 9.88 724 455712 37638 64004658
Overdose 244.21 9.88 474 455962 159092 63883204
Exposure during pregnancy 239.44 9.88 1137 455299 76538 63965758
Acute kidney injury 218.04 9.88 2080 454356 447160 63595136
Musculoskeletal stiffness 214.76 9.88 1551 454885 121655 63920641
Hepatic enzyme increased 206.80 9.88 1601 454835 128342 63913954
Drug intolerance 204.07 9.88 2131 454305 185861 63856435
C-reactive protein abnormal 182.43 9.88 535 455901 28512 64013784
Psoriatic arthropathy 181.75 9.88 696 455740 42585 63999711
Cardiac arrest 180.49 9.88 527 455909 153537 63888759
Suicide attempt 167.69 9.88 153 456283 70854 63971442
Impaired healing 162.82 9.88 852 455584 59621 63982675
Drug reaction with eosinophilia and systemic symptoms 156.16 9.88 95 456341 54122 63988174
Lactic acidosis 155.18 9.88 124 456312 61286 63981010
Red blood cell sedimentation rate abnormal 153.81 9.88 350 456086 15956 64026340
Sopor 150.21 9.88 17 456419 29644 64012652
Sickle cell anaemia with crisis 148.47 9.88 186 456250 5146 64037150
Sinusitis 140.69 9.88 1616 454820 144312 63897984
Bradycardia 139.45 9.88 403 456033 117816 63924480
Muscle injury 133.88 9.88 452 455984 25985 64016311
Sedation 129.00 9.88 66 456370 41396 64000900
Product use issue 128.77 9.88 1640 454796 150075 63892221
Respiratory arrest 125.30 9.88 114 456322 52871 63989425
Blood pressure fluctuation 124.93 9.88 709 455727 51162 63991134
Drug resistance 124.88 9.88 46 456390 35056 64007240
Arthritis 123.62 9.88 1015 455421 82799 63959497
Folliculitis 122.46 9.88 479 455957 29598 64012698
Lower respiratory tract infection 121.38 9.88 1111 455325 93503 63948793
Knee arthroplasty 119.00 9.88 441 455995 26558 64015738
Hip arthroplasty 117.94 9.88 376 456060 20975 64021321
Peripheral swelling 116.57 9.88 2104 454332 207049 63835247
Drug dependence 116.26 9.88 45 456391 33267 64009029
Product use in unapproved indication 116.08 9.88 752 455684 175866 63866430
Sleep disorder due to general medical condition, insomnia type 114.87 9.88 428 456008 25842 64016454
Irritable bowel syndrome 111.48 9.88 542 455894 36827 64005469
Hypersensitivity 110.80 9.88 1980 454456 194472 63847824
Hypotension 107.59 9.88 1973 454463 379001 63663295
Renal failure 106.90 9.88 799 455637 180889 63861407
Coma 106.76 9.88 294 456142 87321 63954975
Interstitial lung disease 106.46 9.88 1109 455327 96623 63945673
Treatment failure 106.09 9.88 1279 455157 115537 63926759
Hypermagnesaemia 105.15 9.88 76 456360 1021 64041275
C-reactive protein increased 104.34 9.88 1079 455357 93830 63948466
Pregnancy 104.12 9.88 355 456081 20510 64021786
Agitation 102.19 9.88 304 456132 88063 63954233
Intentional product misuse 101.05 9.88 226 456210 72069 63970227
Abortion spontaneous 94.82 9.88 391 456045 24752 64017544
Serotonin syndrome 94.70 9.88 83 456353 39199 64003097
Osteoarthritis 90.70 9.88 762 455674 62574 63979722
Poisoning 89.92 9.88 22 456414 21857 64020439
Intentional self-injury 89.22 9.88 47 456389 28997 64013299
Blister 88.28 9.88 919 455517 80048 63962248
Weight increased 87.76 9.88 2052 454384 211296 63831000
Infection 87.39 9.88 1814 454622 183066 63859230
Psoriasis 86.96 9.88 832 455604 70871 63971425
Device expulsion 85.42 9.88 22 456414 21114 64021182
Enthesopathy 82.31 9.88 199 456237 9439 64032857
Injection site erythema 82.17 9.88 814 455622 69986 63972310
Drug withdrawal syndrome 80.54 9.88 62 456374 31229 64011067
Multiple organ dysfunction syndrome 79.93 9.88 407 456029 101006 63941290
Cholestasis 78.88 9.88 122 456314 44750 63997546
Hepatocellular injury 77.61 9.88 125 456311 45110 63997186
Rhabdomyolysis 77.58 9.88 359 456077 91367 63950929
Red blood cell sedimentation rate increased 77.23 9.88 430 456006 30805 64011491
Juvenile idiopathic arthritis 75.77 9.88 114 456322 3765 64038531
Contusion 73.08 9.88 1173 455263 112792 63929504
Joint effusion 72.36 9.88 235 456201 13238 64029058
Angioedema 71.96 9.88 212 456224 61609 63980687
Stomatitis 71.74 9.88 1132 455304 108473 63933823
Hyperhidrosis 71.72 9.88 553 455883 124367 63917929
Ill-defined disorder 71.25 9.88 545 455891 43507 63998789
Metabolic acidosis 71.08 9.88 260 456176 70698 63971598
Live birth 70.95 9.88 207 456229 10997 64031299
Anxiety 70.20 9.88 1010 455426 201639 63840657
Disability assessment scale score increased 70.03 9.88 88 456348 2442 64039854
Drug hypersensitivity 69.75 9.88 1223 455213 236592 63805704
Blood pressure diastolic abnormal 69.63 9.88 214 456222 11703 64030593
Tachycardia 69.18 9.88 700 455736 148879 63893417
Osteoporosis 67.72 9.88 520 455916 41560 64000736
Blood pressure systolic increased 67.66 9.88 589 455847 48864 63993432
Depressed level of consciousness 66.94 9.88 322 456114 81114 63961182
Injection site pruritus 66.88 9.88 478 455958 37348 64004948
Rheumatoid nodule 66.45 9.88 219 456217 12432 64029864
Blood pressure systolic abnormal 66.17 9.88 187 456249 9755 64032541
Myocardial infarction 65.61 9.88 804 455632 165017 63877279
Neutropenia 65.35 9.88 1248 455188 238376 63803920
Syncope 65.17 9.88 757 455679 156878 63885418
Rheumatic fever 65.00 9.88 178 456258 9116 64033180
Electrocardiogram QT prolonged 64.80 9.88 315 456121 79133 63963163
Disturbance in attention 63.66 9.88 121 456315 40953 64001343
Rash 62.90 9.88 3902 452534 454647 63587649
Somnolence 62.38 9.88 1039 455397 202606 63839690
Caesarean section 61.77 9.88 198 456238 11076 64031220
Swollen joint count increased 60.64 9.88 154 456282 7535 64034761
Blood pressure diastolic decreased 60.55 9.88 315 456121 21986 64020310
Cardio-respiratory arrest 60.09 9.88 428 456008 97965 63944331
Grip strength decreased 59.84 9.88 201 456235 11523 64030773
Tenosynovitis 59.63 9.88 202 456234 11631 64030665
Femur fracture 59.56 9.88 430 456006 33705 64008591
Dyspnoea 58.83 9.88 4336 452100 714338 63327958
Immune reconstitution inflammatory syndrome 58.71 9.88 9 456427 12461 64029835
Joint laxity 58.58 9.88 77 456359 2237 64040059
Urticaria 57.25 9.88 717 455719 146600 63895696
Myalgia 56.88 9.88 785 455651 157832 63884464
Mydriasis 56.29 9.88 19 456417 15293 64027003
Hepatic failure 56.12 9.88 202 456234 55192 63987104
Acute hepatic failure 55.09 9.88 62 456374 26050 64016246
Injection site reaction 53.89 9.88 536 455900 46128 63996168
Respiratory depression 53.59 9.88 52 456384 23391 64018905
Hypoglycaemia 52.02 9.88 397 456039 89495 63952801
Tremor 51.94 9.88 737 455699 147493 63894803
Injection site pain 51.58 9.88 1090 455346 110318 63931978
Foot deformity 51.12 9.88 242 456194 16262 64026034
Injection site swelling 50.70 9.88 481 455955 40872 64001424
Fibromyalgia 50.68 9.88 429 456007 35302 64006994
Cognitive disorder 50.58 9.88 209 456227 54878 63987418
Gestational diabetes 50.53 9.88 118 456318 5472 64036824
Asthenia 50.06 9.88 2497 453939 425547 63616749
Condition aggravated 49.88 9.88 3163 453273 369263 63673033
Suicidal ideation 49.66 9.88 272 456164 66270 63976026
Cytomegalovirus infection 49.00 9.88 120 456316 37079 64005217
Constipation 48.85 9.88 1242 455194 228095 63814201
Polyarthritis 48.21 9.88 165 456271 9550 64032746
Musculoskeletal pain 48.14 9.88 826 455610 80468 63961828
Localised infection 48.13 9.88 372 456064 29789 64012507
Substance abuse 47.88 9.88 5 456431 9287 64033009
Herpes zoster 47.04 9.88 805 455631 78382 63963914
Heart rate decreased 46.97 9.88 596 455840 54471 63987825
Platelet count decreased 46.57 9.88 1534 454902 166177 63876119
Unresponsive to stimuli 46.39 9.88 191 456245 50202 63992094
Psychotic disorder 45.97 9.88 111 456325 34467 64007829
Pathogen resistance 45.35 9.88 16 456420 12527 64029769
Diabetic ketoacidosis 45.31 9.88 89 456347 29756 64012540
Disease progression 44.63 9.88 719 455717 140961 63901335
Pancytopenia 44.32 9.88 1328 455108 141981 63900315
Off label use 44.16 9.88 3867 452569 628939 63413357
Basal cell carcinoma 44.13 9.88 371 456065 30467 64011829
Vision blurred 44.12 9.88 417 456019 89899 63952397
Emotional distress 43.83 9.88 121 456315 35917 64006379
Accidental overdose 43.61 9.88 109 456327 33448 64008848
Fracture 43.60 9.88 254 456182 18501 64023795
Blood pressure diastolic increased 43.57 9.88 171 456265 10581 64031715
Irritability 43.49 9.88 125 456311 36621 64005675
Bone erosion 43.47 9.88 180 456256 11415 64030881
Haemoglobin decreased 42.68 9.88 1737 454699 193326 63848970
Product quality issue 42.58 9.88 92 456344 29707 64012589
Inflammation 42.55 9.88 674 455762 64626 63977670
Hyponatraemia 42.45 9.88 766 455670 147573 63894723
Hypothermia 42.05 9.88 47 456389 19809 64022487
Encephalopathy 41.96 9.88 244 456192 58575 63983721
Speech disorder 41.89 9.88 188 456248 48253 63994043
Joint stiffness 41.52 9.88 362 456074 30042 64012254
Tongue disorder 41.03 9.88 182 456254 11898 64030398
Blood pressure increased 40.90 9.88 1550 454886 171002 63871294
Balance disorder 40.78 9.88 388 456048 83538 63958758
Drug ineffective for unapproved indication 40.56 9.88 101 456335 31032 64011264
Premature delivery 40.18 9.88 247 456189 18342 64023954
Disorientation 40.14 9.88 231 456205 55597 63986699
Hepatic function abnormal 39.73 9.88 658 455778 63655 63978641
Neurotoxicity 39.66 9.88 84 456352 27320 64014976
Febrile neutropenia 39.48 9.88 1018 455418 186639 63855657
Cardiogenic shock 39.35 9.88 109 456327 32318 64009978
Pain in extremity 39.26 9.88 2567 453869 300518 63741778
Premature labour 39.21 9.88 131 456305 7489 64034807
Respiratory failure 38.99 9.88 856 455580 160327 63881969
Pulmonary fibrosis 38.88 9.88 352 456084 29526 64012770
Injection site bruising 38.76 9.88 411 456025 35962 64006334
Aggression 38.45 9.88 182 456254 46050 63996246
Respiratory distress 38.45 9.88 215 456221 52116 63990180
Coronary artery disease 38.30 9.88 260 456176 60173 63982123
Psychomotor hyperactivity 38.00 9.88 28 456408 14423 64027873
Haematotoxicity 37.97 9.88 22 456414 12874 64029422
Posterior reversible encephalopathy syndrome 37.88 9.88 65 456371 22881 64019415
Oropharyngeal pain 37.80 9.88 859 455577 88008 63954288
Mucormycosis 37.70 9.88 4 456432 7337 64034959
Maternal exposure before pregnancy 37.67 9.88 79 456357 3404 64038892
Dizziness 37.57 9.88 2580 453856 427583 63614713
Neuropathy peripheral 37.49 9.88 595 455841 116930 63925366
Neck deformity 37.34 9.88 53 456383 1659 64040637
Loss of personal independence in daily activities 36.88 9.88 719 455717 71735 63970561
Asthma 36.78 9.88 464 455972 94761 63947535
Tenderness 36.58 9.88 251 456185 19351 64022945
Pre-eclampsia 36.50 9.88 112 456324 6119 64036177
Joint destruction 36.48 9.88 80 456356 3556 64038740
Infective pulmonary exacerbation of cystic fibrosis 36.36 9.88 19 456417 11777 64030519
Sedation complication 36.10 9.88 14 456422 10340 64031956
Hallucination 36.01 9.88 335 456101 72453 63969843
Fatigue 35.98 9.88 5924 450512 742806 63299490
Alanine aminotransferase abnormal 35.96 9.88 119 456317 6769 64035527
Bradyphrenia 35.76 9.88 11 456425 9395 64032901
Anaphylactic reaction 35.72 9.88 312 456124 68352 63973944
Body temperature decreased 35.56 9.88 309 456127 25619 64016677
Nodule 35.41 9.88 233 456203 17714 64024582
Cerebrovascular accident 35.22 9.88 724 455712 136859 63905437
Thrombocytopenia 35.04 9.88 1263 455173 222538 63819758
Neuroleptic malignant syndrome 35.03 9.88 78 456358 24918 64017378
Withdrawal syndrome 34.85 9.88 71 456365 23421 64018875
Forced expiratory volume decreased 34.61 9.88 4 456432 6863 64035433
Shock 34.54 9.88 146 456290 38094 64004202
Gastrointestinal disorder 34.45 9.88 855 455581 88854 63953442
Hypertransaminasaemia 34.29 9.88 5 456431 7186 64035110
Multiple sclerosis relapse 34.17 9.88 162 456274 40973 64001323
Venoocclusive liver disease 34.17 9.88 14 456422 10001 64032295
Injection site rash 33.91 9.88 209 456227 15533 64026763
Ejection fraction decreased 33.72 9.88 98 456338 28609 64013687
Hyperglycaemia 33.53 9.88 273 456163 60695 63981601
Product administration error 33.48 9.88 93 456343 27550 64014746
Ischaemic stroke 33.47 9.88 100 456336 28935 64013361
Eosinophilia 33.39 9.88 147 456289 37929 64004367
Tendonitis 33.39 9.88 252 456184 20030 64022266
Agranulocytosis 33.28 9.88 148 456288 38081 64004215
Synovial cyst 33.22 9.88 125 456311 7582 64034714
Red blood cell sedimentation rate 33.13 9.88 78 456358 3636 64038660
Post transplant lymphoproliferative disorder 33.12 9.88 13 456423 9531 64032765
Myoclonus 33.10 9.88 81 456355 25037 64017259
Depression 33.02 9.88 1016 455420 182275 63860021
Premature rupture of membranes 32.72 9.88 78 456358 3666 64038630
Limb deformity 32.65 9.88 73 456363 3288 64039008
Liver disorder 32.64 9.88 545 455891 52806 63989490
Extrapyramidal disorder 32.63 9.88 55 456381 19497 64022799
Skin ulcer 32.58 9.88 464 455972 43510 63998786
Fear 32.52 9.88 58 456378 20113 64022183
Paradoxical drug reaction 32.30 9.88 3 456433 6117 64036179
Abnormal behaviour 31.85 9.88 126 456310 33496 64008800
No adverse event 31.76 9.88 100 456336 28461 64013835
Red blood cell count decreased 31.74 9.88 500 455936 47886 63994410
Orthostatic hypotension 31.69 9.88 197 456239 46541 63995755
Brain oedema 31.67 9.88 68 456368 22007 64020289
Seizure 31.57 9.88 919 455517 165973 63876323
Bronchitis 31.56 9.88 1000 455436 107743 63934553
Bronchospasm 30.93 9.88 67 456369 21615 64020681
Dysarthria 30.87 9.88 270 456166 59136 63983160
Neck mass 30.86 9.88 80 456356 3964 64038332
Leukopenia 30.82 9.88 517 455919 100725 63941571
Smear cervix abnormal 30.67 9.88 58 456378 2316 64039980
Febrile bone marrow aplasia 30.66 9.88 21 456415 11234 64031062
Flushing 30.45 9.88 383 456053 78265 63964031
Latent tuberculosis 30.36 9.88 63 456373 2694 64039602
Laryngitis 30.08 9.88 156 456280 10875 64031421
Drug ineffective 29.88 9.88 6548 449888 833699 63208597
Second primary malignancy 29.82 9.88 26 456410 12311 64029985
Disability 29.71 9.88 167 456269 12005 64030291
Non-small cell lung cancer 29.68 9.88 89 456347 4801 64037495
Multiple fractures 29.46 9.88 102 456334 5938 64036358
Pulmonary embolism 29.45 9.88 799 455637 145557 63896739
Drug use disorder 29.36 9.88 4 456432 6050 64036246
Oral herpes 29.34 9.88 262 456174 21890 64020406
Aspergillus infection 29.30 9.88 44 456392 16335 64025961
Status epilepticus 29.23 9.88 69 456367 21594 64020702
Unintentional medical device removal 29.22 9.88 6 456430 6728 64035568
Joint injury 29.17 9.88 269 456167 22678 64019618
Anaphylactic shock 29.14 9.88 113 456323 30215 64012081
Rash maculo-papular 28.97 9.88 204 456232 46822 63995474
Acute graft versus host disease 28.95 9.88 14 456422 9070 64033226
Wrong technique in product usage process 28.82 9.88 307 456129 64667 63977629
Spinal stenosis 28.79 9.88 183 456253 13748 64028548
Toxic epidermal necrolysis 28.79 9.88 150 456286 37016 64005280
Haematocrit decreased 28.71 9.88 545 455891 54110 63988186
Arthritis infective 28.64 9.88 112 456324 6918 64035378
Vomiting 28.38 9.88 3441 452995 547676 63494620
Joint range of motion decreased 28.36 9.88 234 456202 19109 64023187
Muscle spasms 28.34 9.88 770 455666 140253 63902043
Wheelchair user 28.33 9.88 85 456351 4587 64037709
Coagulopathy 28.13 9.88 123 456313 31797 64010499
Polyneuropathy 27.95 9.88 62 456374 19832 64022464
Fluid retention 27.93 9.88 278 456158 59328 63982968
Surgery 27.85 9.88 314 456122 27899 64014397
Cardiac failure congestive 27.55 9.88 708 455728 129872 63912424
Confusional state 27.52 9.88 1539 454897 259605 63782691
Miosis 27.44 9.88 32 456404 13234 64029062
Influenza 27.43 9.88 966 455470 105565 63936731
Mental status changes 27.12 9.88 289 456147 60873 63981423
Neutrophil count decreased 27.09 9.88 727 455709 76469 63965827
Torsade de pointes 27.03 9.88 51 456385 17312 64024984
Vertigo 26.91 9.88 277 456159 58734 63983562
Cardiac failure 26.80 9.88 722 455714 131651 63910645
Thrombotic microangiopathy 26.75 9.88 48 456388 16607 64025689
Tenosynovitis stenosans 26.71 9.88 49 456387 1911 64040385
Adenovirus infection 26.67 9.88 9 456427 7246 64035050
Hyperthermia 26.64 9.88 43 456393 15507 64026789
Lung neoplasm malignant 26.55 9.88 250 456186 21198 64021098
Pneumonia 26.54 9.88 4425 452011 555151 63487145
Drug level increased 26.50 9.88 138 456298 34058 64008238
Transplant rejection 26.32 9.88 52 456384 17349 64024947
Progressive multifocal leukoencephalopathy 26.29 9.88 56 456380 18176 64024120
Tuberculosis 26.16 9.88 170 456266 12868 64029428
Ventricular tachycardia 26.15 9.88 139 456297 34126 64008170
Arrhythmia 26.04 9.88 244 456192 52700 63989596
Chest pain 25.92 9.88 1385 455051 234595 63807701
Acute generalised exanthematous pustulosis 25.89 9.88 37 456399 14021 64028275
Exposure to toxic agent 25.69 9.88 6 456430 6153 64036143
Incorrect route of product administration 25.61 9.88 82 456354 23216 64019080
Poor venous access 25.59 9.88 163 456273 12254 64030042
Creatinine renal clearance decreased 25.54 9.88 39 456397 14382 64027914
Tachypnoea 25.53 9.88 99 456337 26472 64015824
Skin papilloma 25.50 9.88 88 456348 5115 64037181
Cellulitis 25.30 9.88 854 455582 92803 63949493
Immunodeficiency 25.24 9.88 198 456238 15926 64026370
Fear of injection 24.75 9.88 95 456341 5817 64036479
Skin cancer 24.56 9.88 157 456279 11817 64030479
Muscle spasticity 24.20 9.88 51 456385 16618 64025678
Neoplasm progression 24.13 9.88 180 456256 40784 64001512
Acute coronary syndrome 24.11 9.88 64 456372 19246 64023050
Gastroenteritis viral 23.94 9.88 229 456207 19500 64022796
Device use error 23.84 9.88 8 456428 6463 64035833
Rotator cuff repair 23.70 9.88 40 456396 1459 64040837
Synovial fluid analysis 23.66 9.88 41 456395 1528 64040768
Malignant melanoma 23.60 9.88 165 456271 12799 64029497
Ventricular fibrillation 23.51 9.88 88 456348 23772 64018524
Anhedonia 23.39 9.88 38 456398 13668 64028628
Chest discomfort 23.31 9.88 634 455802 115472 63926824
Bone disorder 23.12 9.88 200 456236 16559 64025737
Joint noise 22.96 9.88 62 456374 3149 64039147
Hepatotoxicity 22.87 9.88 177 456259 39785 64002511
Blood parathyroid hormone decreased 22.80 9.88 108 456328 7258 64035038
BK virus infection 22.75 9.88 12 456424 7400 64034896
Loose body in joint 22.67 9.88 35 456401 1183 64041113
Renal injury 22.57 9.88 47 456389 15382 64026914
Obstructive airways disorder 22.53 9.88 86 456350 23099 64019197
Acute chest syndrome 22.45 9.88 30 456406 886 64041410
Potentiating drug interaction 22.27 9.88 14 456422 7838 64034458
Muscle twitching 22.21 9.88 65 456371 18933 64023363
Respiratory disorder 22.07 9.88 157 456279 35954 64006342
Labelled drug-drug interaction medication error 21.98 9.88 81 456355 21981 64020315
Lip swelling 21.89 9.88 134 456302 31773 64010523
Pulmonary tuberculosis 21.55 9.88 105 456331 7139 64035157
Akathisia 21.49 9.88 30 456406 11480 64030816
Fracture delayed union 21.44 9.88 45 456391 1940 64040356
Upper respiratory tract inflammation 21.25 9.88 67 456369 3715 64038581
Affective disorder 21.18 9.88 10 456426 6570 64035726
Foot fracture 21.17 9.88 209 456227 17948 64024348
Maternal exposure timing unspecified 21.12 9.88 54 456382 2653 64039643
Bronchopulmonary aspergillosis 21.10 9.88 67 456369 19018 64023278
Device difficult to use 20.96 9.88 23 456413 9775 64032521
Endophthalmitis 20.90 9.88 6 456430 5359 64036937
Cancer pain 20.86 9.88 72 456364 4185 64038111
Nausea 20.59 9.88 5092 451344 780708 63261588
Sexual dysfunction 20.58 9.88 10 456426 6461 64035835
Electrocardiogram QRS complex prolonged 20.56 9.88 21 456415 9223 64033073
Haemorrhage 20.47 9.88 417 456019 78934 63963362
Injection site warmth 20.36 9.88 164 456272 13298 64028998
Nightmare 20.31 9.88 78 456358 20915 64021381
Graft versus host disease 20.27 9.88 42 456394 13771 64028525
Diarrhoea 20.20 9.88 4669 451767 718035 63324261
Ileus 20.19 9.88 250 456186 22716 64019580
Hemiparesis 20.08 9.88 126 456310 29701 64012595
Polyhydramnios 20.05 9.88 37 456399 1450 64040846
Pancreatitis 19.94 9.88 299 456137 59308 63982988
Aphasia 19.91 9.88 189 456247 40717 64001579
Foetal death 19.88 9.88 89 456347 5841 64036455
Panniculitis 19.83 9.88 119 456317 8760 64033536
Respiration abnormal 19.72 9.88 10 456426 6305 64035991
Alcohol abuse 19.70 9.88 5 456431 4847 64037449
Visual acuity reduced 19.67 9.88 112 456324 27029 64015267
Therapeutic response decreased 19.62 9.88 496 455940 51692 63990604
Haematoma 19.52 9.88 221 456215 46029 63996267
Threatened labour 19.51 9.88 22 456414 543 64041753
Blood creatine phosphokinase increased 19.50 9.88 294 456142 58264 63984032
Granuloma skin 19.50 9.88 90 456346 5984 64036312
Coronary arterial stent insertion 19.35 9.88 8 456428 5684 64036612
Acute respiratory distress syndrome 19.34 9.88 179 456257 38756 64003540
Pneumonia aspiration 19.33 9.88 553 455883 58718 63983578
Pulmonary oedema 19.25 9.88 417 456019 78257 63964039
Cystitis 19.24 9.88 416 456020 42259 64000037
Post procedural infection 19.18 9.88 125 456311 9472 64032824
Bone pain 19.04 9.88 230 456206 47342 63994954
Breast feeding 18.91 9.88 24 456412 673 64041623
Chronic kidney disease 18.87 9.88 292 456144 57627 63984669
Transaminases increased 18.86 9.88 213 456223 44381 63997915
Hypoxia 18.84 9.88 477 455959 87672 63954624
Mania 18.84 9.88 56 456380 16230 64026066
Ulcer 18.83 9.88 247 456189 22743 64019553
Pancreatitis acute 18.79 9.88 203 456233 42652 63999644
Palmar-plantar erythrodysaesthesia syndrome 18.75 9.88 123 456313 28696 64013600
Acute myocardial infarction 18.69 9.88 364 456072 69354 63972942
Generalised tonic-clonic seizure 18.62 9.88 186 456250 39671 64002625
Joint dislocation 18.62 9.88 142 456294 11323 64030973
Lethargy 18.57 9.88 382 456054 72212 63970084
Ear infection 18.57 9.88 250 456186 23154 64019142
Memory impairment 18.49 9.88 463 455973 85219 63957077
Restlessness 18.45 9.88 186 456250 39599 64002697
Drug abuser 18.43 9.88 9 456427 5799 64036497
Nephropathy toxic 18.32 9.88 63 456373 17451 64024845
Acute respiratory failure 18.28 9.88 246 456190 49688 63992608
Rebound effect 18.25 9.88 6 456430 4911 64037385
Antinuclear antibody positive 18.17 9.88 90 456346 6160 64036136
Jaundice 18.13 9.88 238 456198 48274 63994022
Anuria 18.00 9.88 71 456365 18893 64023403
Drug screen positive 18.00 9.88 9 456427 5720 64036576
Hepatic cytolysis 17.97 9.88 46 456390 14003 64028293
Postoperative wound infection 17.91 9.88 130 456306 10206 64032090
Hyperlactacidaemia 17.82 9.88 6 456430 4838 64037458
Melaena 17.78 9.88 269 456167 53279 63989017
Proteinuria 17.70 9.88 119 456317 27604 64014692
Dystonia 17.67 9.88 71 456365 18794 64023502
Rash erythematous 17.66 9.88 240 456196 48393 63993903
Gastroenteritis 17.62 9.88 302 456134 29409 64012887
Dactylitis 17.62 9.88 41 456395 1897 64040399
Haemorrhage intracranial 17.61 9.88 98 456338 23786 64018510
Colon cancer 17.56 9.88 152 456284 12587 64029709
Myopathy 17.55 9.88 65 456371 17615 64024681
Mouth ulceration 17.55 9.88 325 456111 32119 64010177
Muscle rigidity 17.51 9.88 64 456372 17409 64024887
Nocardiosis 17.38 9.88 6 456430 4761 64037535
Graft versus host disease in gastrointestinal tract 17.36 9.88 9 456427 5603 64036693
Synovial disorder 17.31 9.88 27 456409 921 64041375
Leukocytosis 17.27 9.88 177 456259 37563 64004733
Drug eruption 17.18 9.88 355 456081 35781 64006515
Dyspnoea exertional 17.12 9.88 394 456042 73336 63968960
Acute graft versus host disease in skin 17.11 9.88 14 456422 6841 64035455
Scleritis 17.08 9.88 53 456383 2913 64039383
Tardive dyskinesia 17.06 9.88 24 456412 9154 64033142
Cardiotoxicity 17.05 9.88 29 456407 10245 64032051
Hepatitis cholestatic 16.98 9.88 38 456398 12117 64030179
Coordination abnormal 16.92 9.88 52 456384 14912 64027384
Gestational hypertension 16.88 9.88 37 456399 1644 64040652
Pulseless electrical activity 16.85 9.88 41 456395 12698 64029598
Cyanosis 16.83 9.88 90 456346 22065 64020231
Asphyxia 16.82 9.88 26 456410 9540 64032756
Clostridium difficile colitis 16.81 9.88 118 456318 27105 64015191
Crying 16.76 9.88 79 456357 20011 64022285
Product prescribing error 16.73 9.88 164 456272 35105 64007191
Induced labour 16.72 9.88 25 456411 821 64041475
Spinal compression fracture 16.71 9.88 169 456267 14606 64027690
Epstein-Barr virus infection 16.67 9.88 40 456396 12448 64029848
Acidosis 16.65 9.88 67 456369 17728 64024568
Cardiomyopathy 16.61 9.88 108 456328 25248 64017048
Blood glucose increased 16.59 9.88 548 455888 97525 63944771
Hallucination, visual 16.54 9.88 122 456314 27712 64014584
Disease recurrence 16.46 9.88 143 456293 31367 64010929
Accidental exposure to product 16.42 9.88 114 456322 26250 64016046
Normal newborn 16.41 9.88 81 456355 5536 64036760
Bradypnoea 16.37 9.88 8 456428 5151 64037145
Clavicle fracture 16.32 9.88 61 456375 3688 64038608
Sinus bradycardia 16.30 9.88 95 456341 22798 64019498
Foetal distress syndrome 16.30 9.88 18 456418 434 64041862
Rhinorrhoea 16.24 9.88 547 455889 59422 63982874
Pharyngitis 16.20 9.88 206 456230 18833 64023463
Respiratory acidosis 16.19 9.88 28 456408 9827 64032469
Feeling abnormal 16.02 9.88 777 455659 132825 63909471
Compartment syndrome 16.00 9.88 5 456431 4227 64038069
International normalised ratio increased 15.96 9.88 432 456004 78735 63963561
Diabetes insipidus 15.95 9.88 6 456430 4515 64037781
Klebsiella infection 15.85 9.88 45 456391 13236 64029060
Skin exfoliation 15.76 9.88 223 456213 44662 63997634
Endodontic procedure 15.76 9.88 44 456392 2279 64040017
Stillbirth 15.72 9.88 59 456377 3574 64038722
Hypotonia 15.70 9.88 35 456401 11177 64031119
Wound infection pseudomonas 15.69 9.88 34 456402 1499 64040797
Uterine perforation 15.67 9.88 11 456425 5809 64036487
Iodine allergy 15.64 9.88 19 456417 509 64041787
Arthritis bacterial 15.60 9.88 102 456334 7737 64034559
Complication of device insertion 15.56 9.88 8 456428 5004 64037292
Oxygen saturation decreased 15.55 9.88 917 455519 106259 63936037
Serum ferritin increased 15.54 9.88 108 456328 8360 64033936
Presyncope 15.47 9.88 166 456270 34923 64007373
Ingrown hair 15.45 9.88 20 456416 572 64041724
Haemophagocytic lymphohistiocytosis 15.43 9.88 68 456368 17541 64024755
Haemodynamic instability 15.35 9.88 54 456382 14858 64027438
Virologic failure 15.23 9.88 3 456433 3463 64038833
Radiation pneumonitis 15.20 9.88 55 456381 3273 64039023
Human antichimeric antibody positive 15.18 9.88 32 456404 1384 64040912
Lacrimal disorder 15.08 9.88 18 456418 473 64041823
Haemorrhage in pregnancy 14.99 9.88 30 456406 1250 64041046
Toxic skin eruption 14.84 9.88 78 456358 19206 64023090
Accidental death 14.82 9.88 4 456432 3721 64038575
Placental disorder 14.81 9.88 24 456412 846 64041450
Atrial fibrillation 14.74 9.88 1027 455409 170062 63872234
Pulmonary arterial hypertension 14.68 9.88 112 456324 25255 64017041
Cross sensitivity reaction 14.61 9.88 3 456433 3364 64038932
Placental insufficiency 14.54 9.88 26 456410 994 64041302
Personality change 14.50 9.88 24 456412 8569 64033727
Lymphatic fistula 14.41 9.88 22 456414 736 64041560
Panic attack 14.37 9.88 88 456348 20865 64021431
Femoral hernia incarcerated 14.35 9.88 22 456414 739 64041557
Lupus-like syndrome 14.34 9.88 109 456327 8682 64033614
Intracranial pressure increased 14.31 9.88 17 456419 6972 64035324
Chronic graft versus host disease 14.25 9.88 14 456422 6262 64036034
Temperature regulation disorder 14.18 9.88 6 456430 4205 64038091
Pain in jaw 14.13 9.88 203 456233 40552 64001744
Abortion threatened 14.12 9.88 16 456420 397 64041899
Toothache 14.06 9.88 187 456249 17272 64025024
Cushingoid 13.97 9.88 97 456339 7506 64034790
Delivery 13.90 9.88 18 456418 515 64041781
Palpitations 13.87 9.88 601 455835 103887 63938409
Mental disorder 13.82 9.88 120 456316 26325 64015971
Paranoia 13.82 9.88 64 456372 16288 64026008
Tooth disorder 13.76 9.88 229 456207 22173 64020123
Medication error 13.66 9.88 260 456176 49706 63992590
Blood cholesterol increased 13.64 9.88 457 455979 49609 63992687
Clear cell renal cell carcinoma 13.55 9.88 40 456396 2139 64040157
Hyperbilirubinaemia 13.55 9.88 91 456345 21114 64021182
Erectile dysfunction 13.49 9.88 45 456391 12582 64029714
Anal fistula 13.44 9.88 73 456363 5180 64037116
Upper respiratory tract infection 13.43 9.88 637 455799 72148 63970148
Hyperkalaemia 13.36 9.88 582 455854 100547 63941749
Blood lactic acid increased 13.35 9.88 34 456402 10367 64031929
Pharyngitis streptococcal 13.33 9.88 106 456330 8562 64033734
Paralysis 13.32 9.88 40 456396 11555 64030741
Myocardial ischaemia 13.30 9.88 103 456333 23148 64019148
Appendicolith 13.29 9.88 4 456432 3465 64038831
Laryngospasm 13.15 9.88 4 456432 3441 64038855
Kidney infection 13.12 9.88 188 456248 17650 64024646
Sinus tachycardia 13.12 9.88 155 456281 32033 64010263
Dysgeusia 13.11 9.88 244 456192 46803 63995493
Multiple-drug resistance 13.11 9.88 16 456420 6486 64035810
Aplasia 13.10 9.88 18 456418 6935 64035361
Bone density abnormal 13.08 9.88 46 456390 2699 64039597
Anger 13.07 9.88 62 456374 15679 64026617
Transplant dysfunction 13.01 9.88 17 456419 6691 64035605
Cervical incompetence 12.90 9.88 17 456419 495 64041801
Body height below normal 12.89 9.88 35 456401 1783 64040513
Cerebral infarction 12.85 9.88 381 456055 40663 64001633
Abortion incomplete 12.73 9.88 3 456433 3058 64039238
Intentional product use issue 12.73 9.88 810 455626 94554 63947742
Gastrointestinal haemorrhage 12.62 9.88 787 455649 131525 63910771
Depressed mood 12.61 9.88 209 456227 40803 64001493
Maternal exposure during breast feeding 12.53 9.88 37 456399 1979 64040317
Angina pectoris 12.51 9.88 234 456202 44847 63997449
Urinary tract infection 12.49 9.88 1845 454591 229751 63812545
Adverse event 12.48 9.88 367 456069 39122 64003174
Malignant mediastinal neoplasm 12.34 9.88 17 456419 517 64041779
Colitis microscopic 12.32 9.88 21 456415 7411 64034885
Cytomegalovirus chorioretinitis 12.30 9.88 10 456426 4902 64037394
Alcohol interaction 12.27 9.88 8 456428 4393 64037903
Joint lock 12.27 9.88 46 456390 2785 64039511
Pyelonephritis acute 12.24 9.88 70 456366 5064 64037232
Unevaluable event 12.23 9.88 268 456168 50221 63992075
Face oedema 12.22 9.88 114 456322 24647 64017649
Stoma site pruritus 12.21 9.88 4 456432 6 64042290
Catatonia 12.20 9.88 22 456414 7598 64034698
Sickle cell anaemia 12.20 9.88 18 456418 584 64041712
Cholecystitis chronic 12.20 9.88 30 456406 9257 64033039
Renal tubular necrosis 12.16 9.88 99 456337 22011 64020285
Chills 12.15 9.88 822 455614 136442 63905854
Psychomotor skills impaired 12.14 9.88 6 456430 3839 64038457
Dislocation of vertebra 12.11 9.88 49 456387 3075 64039221
Ataxia 12.09 9.88 99 456337 21985 64020311
Coronary artery bypass 12.06 9.88 14 456422 5801 64036495
Device dislocation 12.03 9.88 94 456342 21084 64021212
Dyskinesia 12.02 9.88 201 456235 39187 64003109
Therapy partial responder 12.02 9.88 35 456401 10213 64032083
Product administered to patient of inappropriate age 11.99 9.88 9 456427 4592 64037704
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.97 9.88 3 456433 2933 64039363
Frequent bowel movements 11.94 9.88 189 456247 18116 64024180
Arthropod bite 11.92 9.88 85 456351 6636 64035660
Pleuritic pain 11.90 9.88 98 456338 7998 64034298
Lymphangiosis carcinomatosa 11.87 9.88 34 456402 1787 64040509
Joint warmth 11.84 9.88 29 456407 1387 64040909
Swollen tongue 11.81 9.88 175 456261 34779 64007517
Pseudomonas infection 11.80 9.88 76 456360 17807 64024489
Injection site urticaria 11.75 9.88 126 456310 11055 64031241
Small for dates baby 11.72 9.88 15 456421 424 64041872
Immunosuppression 11.72 9.88 122 456314 10624 64031672
Palindromic rheumatism 11.65 9.88 13 456423 317 64041979
Mass 11.64 9.88 162 456274 15114 64027182
Tooth infection 11.60 9.88 156 456280 14445 64027851
Oesophageal fibrosis 11.59 9.88 10 456426 176 64042120
Adjustment disorder with depressed mood 11.56 9.88 41 456395 2416 64039880
Hepatitis acute 11.55 9.88 52 456384 13337 64028959
Human anti-human antibody test 11.55 9.88 14 456422 374 64041922
Ankle arthroplasty 11.54 9.88 22 456414 884 64041412
Wound infection 11.47 9.88 158 456278 14706 64027590
Spinal disorder 11.47 9.88 103 456333 8619 64033677
Candida infection 11.42 9.88 155 456281 31264 64011032
Device leakage 11.42 9.88 26 456410 8240 64034056
White blood cell count increased 11.39 9.88 574 455862 65440 63976856
Rheumatoid lung 11.35 9.88 41 456395 2438 64039858
Enteritis infectious 11.35 9.88 47 456389 2981 64039315
Twin pregnancy 11.32 9.88 21 456415 826 64041470
Lung adenocarcinoma 11.30 9.88 85 456351 6748 64035548
Dry eye 11.26 9.88 277 456159 28742 64013554
Cholestasis of pregnancy 11.22 9.88 22 456414 903 64041393
Antibody test positive 11.18 9.88 40 456396 2367 64039929
Myofascial pain syndrome 11.17 9.88 33 456403 1765 64040531
Failed induction of labour 11.17 9.88 11 456425 231 64042065
Silent thyroiditis 11.14 9.88 9 456427 144 64042152
Glycosylated haemoglobin increased 11.13 9.88 67 456369 15952 64026344
Loss of consciousness 11.13 9.88 901 455535 147464 63894832
Strongyloidiasis 11.07 9.88 4 456432 3086 64039210
Cyst 11.04 9.88 132 456304 11895 64030401
Deep vein thrombosis 11.03 9.88 620 455816 104562 63937734
Mental impairment 11.02 9.88 69 456367 16274 64026022
Mood altered 11.01 9.88 67 456369 15912 64026384
Tuberculin test positive 11.01 9.88 47 456389 3021 64039275
Hepatitis B reactivation 10.99 9.88 11 456425 4878 64037418
Osteomyelitis 10.91 9.88 264 456172 27323 64014973
Abortion missed 10.88 9.88 25 456411 1147 64041149
Gastric cancer 10.87 9.88 81 456355 6412 64035884
Bursitis 10.86 9.88 213 456223 21272 64021024
Nail injury 10.85 9.88 15 456421 458 64041838
Catheter site erythema 10.80 9.88 11 456425 4838 64037458
Metabolic disorder 10.80 9.88 24 456412 7673 64034623
Knee operation 10.78 9.88 62 456374 4495 64037801
Atrioventricular block 10.77 9.88 46 456390 11969 64030327
Hyperpyrexia 10.77 9.88 12 456424 5065 64037231
Drug specific antibody 10.76 9.88 36 456400 2059 64040237
Exostosis 10.71 9.88 126 456310 11312 64030984
Tooth abscess 10.69 9.88 147 456289 13679 64028617
Oliguria 10.64 9.88 60 456376 14516 64027780
Breast abscess 10.62 9.88 24 456412 1089 64041207
Hepatic siderosis 10.60 9.88 9 456427 155 64042141
Osteoporotic fracture 10.59 9.88 52 456384 3546 64038750
Mitochondrial toxicity 10.59 9.88 3 456433 2703 64039593
Blood folate increased 10.56 9.88 15 456421 470 64041826
Mixed liver injury 10.52 9.88 14 456422 5467 64036829
Cell death 10.47 9.88 8 456428 4046 64038250
Hypokalaemia 10.46 9.88 732 455704 121171 63921125
Inappropriate antidiuretic hormone secretion 10.42 9.88 104 456332 22185 64020111
Hyperlipidaemia 10.41 9.88 108 456328 22868 64019428
Injection site extravasation 10.38 9.88 95 456341 7991 64034305
Anticholinergic syndrome 10.37 9.88 3 456433 2666 64039630
Skin ulcer haemorrhage 10.34 9.88 15 456421 479 64041817
Hepatic cyst 10.32 9.88 68 456368 5172 64037124
Acute pulmonary oedema 10.32 9.88 51 456385 12758 64029538
Polydactyly 10.28 9.88 7 456429 85 64042211
Cerebral haemorrhage 10.24 9.88 279 456157 50811 63991485
Product preparation error 10.22 9.88 8 456428 3997 64038299
Vascular insufficiency 10.20 9.88 15 456421 485 64041811
Stress at work 10.20 9.88 22 456414 967 64041329
Vacuum extractor delivery 10.17 9.88 8 456428 123 64042173
Cholinergic syndrome 10.16 9.88 20 456416 823 64041473
Eyelid ptosis 10.14 9.88 34 456402 9491 64032805
Metastases to bone 10.12 9.88 94 456342 20341 64021955
Increased tendency to bruise 10.06 9.88 105 456331 9150 64033146
Iron overload 10.03 9.88 29 456407 1533 64040763
Tubulointerstitial nephritis 10.01 9.88 156 456280 30753 64011543
Rash morbilliform 10.00 9.88 13 456423 5128 64037168
Hypercapnia 9.99 9.88 25 456411 7669 64034627
Retinitis 9.99 9.88 35 456401 2050 64040246
Injection site discolouration 9.99 9.88 83 456353 6792 64035504
Livedo reticularis 9.93 9.88 7 456429 3690 64038606
Skin graft failure 9.93 9.88 10 456426 216 64042080
Pancreatic steatosis 9.91 9.88 22 456414 986 64041310
Arthropod sting 9.89 9.88 21 456415 913 64041383

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02AA02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
ANTACIDS
Magnesium compounds
ATC A06AD02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Osmotically acting laxatives
ATC A12CC10 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
OTHER MINERAL SUPPLEMENTS
Magnesium
MeSH PA D000863 Antacids
MeSH PA D005765 Gastrointestinal Agents
CHEBI has role CHEBI:33287 fertilizers
CHEBI has role CHEBI:65265 antacids

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypocalcemia indication 5291005
Constipation indication 14760008 DOID:2089
Osteoporosis indication 64859006 DOID:11476
Postmenopausal osteoporosis indication 102447009
Indigestion indication 162031009
Hypomagnesemia indication 190855004
Incomplete passage of stool indication 249515001
Peptic ulcer contraindication 13200003 DOID:750
Bipolar disorder contraindication 13746004 DOID:3312
Hyperkalemia contraindication 14140009
Hypocupremia contraindication 19577007
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Metabolic acidosis contraindication 59455009
Diarrhea contraindication 62315008
Blood coagulation disorder contraindication 64779008 DOID:1247
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypercalciuria contraindication 71938000
Gastrointestinal hemorrhage contraindication 74474003
Phototoxicity contraindication 84326006
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Neoplasm of endometrium contraindication 123844007 DOID:1380
Gastrointestinal obstruction contraindication 126765001
Seizure disorder contraindication 128613002
Impaired renal function disorder contraindication 197663003
Osteolysis contraindication 203522001
Hypomania contraindication 231496004
Gastroparesis contraindication 235675006
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Endometrial carcinoma contraindication 254878006 DOID:2871
Esophageal dysmotility contraindication 266434009 DOID:9192
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Primary adrenocortical insufficiency contraindication 373662000
Ketoacidosis in diabetes mellitus contraindication 420422005 DOID:1837
Carcinoma of female breast contraindication 447782002
Genitourinary Tract Infections contraindication
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication
Esophageal Compression contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
12GM/BOT;3.5GM/BOT;10MG/BOT CLENPIQ FERRING PHARMS INC N209589 Nov. 28, 2017 RX SOLUTION ORAL 11191753 June 23, 2034 FOR CLEANSING OF THE COLON AS A PREPARATION FOR COLONOSCOPY
12GM/BOT;3.5GM/BOT;10MG/BOT CLENPIQ FERRING PHARMS INC N209589 Nov. 28, 2017 RX SOLUTION ORAL 9827231 June 26, 2034 FOR CLEANSING THE LARGE INTESTINE AS A PREPARATION FOR COLONOSCOPY

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4020248 VUID
N0000148146 NUI
D01167 KEGG_DRUG
4017641 VANDF
4017717 VANDF
4020248 VANDF
C0024477 UMLSCUI
CHEBI:31794 CHEBI
CHEMBL1200572 ChEMBL_ID
D008277 MESH_DESCRIPTOR_UI
DB01377 DRUGBANK_ID
3A3U0GI71G UNII
6850729 PUBCHEM_CID
6582 RXNORM
40492 MMSL
42624 MMSL
5015 MMSL
5585 MMSL
d03797 MMSL
000788 NDDF
002435 NDDF
419521006 SNOMEDCT_US
66389008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Calcemin Advance HUMAN OTC DRUG LABEL 5 0280-0272 TABLET, FILM COATED 40 mg ORAL Export only 2 sections
Calcemin Silver HUMAN OTC DRUG LABEL 3 0280-0273 TABLET, FILM COATED 40 mg ORAL Export only 2 sections
Magnesium Oxide HUMAN OTC DRUG LABEL 1 0603-0209 TABLET 400 mg ORAL OTC MONOGRAPH FINAL 12 sections
Magnesium Oxide HUMAN OTC DRUG LABEL 1 0603-0213 TABLET 253 mg ORAL OTC MONOGRAPH FINAL 12 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 20 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 25 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 50 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 20 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 25 mg ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 50 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Magnesium Oxide HUMAN OTC DRUG LABEL 1 10135-583 TABLET 400 mg ORAL OTC MONOGRAPH FINAL 12 sections
magnesium oxide HUMAN OTC DRUG LABEL 1 10135-721 TABLET 420 mg ORAL OTC monograph final 9 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-100 LIQUID 10 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-101 LIQUID 12 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-103 TABLET, CHEWABLE 15 mg ORAL UNAPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-104 TABLET, CHEWABLE 15 mg ORAL UNAPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-105 TABLET, CHEWABLE 15 mg ORAL UNAPPROVED DRUG OTHER 12 sections
TriStart DHA HUMAN PRESCRIPTION DRUG LABEL 15 15370-250 CAPSULE, LIQUID FILLED 30 mg ORAL UNAPPROVED DRUG OTHER 12 sections
PNV-Select HUMAN PRESCRIPTION DRUG LABEL 18 42192-320 TABLET, FILM COATED 30 ug ORAL unapproved drug other 10 sections
PNV-Omega HUMAN PRESCRIPTION DRUG LABEL 13 42192-332 CAPSULE, GELATIN COATED 45 mg ORAL unapproved drug other 12 sections
MigralexDr. Mauskop HUMAN OTC DRUG LABEL 2 49886-001 TABLET, COATED 75 mg ORAL OTC monograph not final 13 sections
Nestabs ONE HUMAN PRESCRIPTION DRUG LABEL 10 50967-410 CAPSULE, GELATIN COATED 15 mg ORAL unapproved drug other 12 sections
Nestabs ONE HUMAN PRESCRIPTION DRUG LABEL 10 50967-410 CAPSULE, GELATIN COATED 15 mg ORAL unapproved drug other 12 sections
Magnesium Oxide HUMAN OTC DRUG LABEL 1 53808-0684 TABLET 400 mg ORAL OTC MONOGRAPH FINAL 13 sections
Magnesium Oxide HUMAN OTC DRUG LABEL 1 54738-973 TABLET 400 mg ORAL OTC monograph final 13 sections
Magnesium Oxide HUMAN OTC DRUG LABEL 1 54738-974 TABLET 420 mg ORAL OTC monograph final 13 sections
Magnesium Oxide HUMAN OTC DRUG LABEL 1 54868-5110 TABLET 400 mg ORAL OTC monograph final 13 sections
CLENPIQ HUMAN PRESCRIPTION DRUG LABEL 3 55566-6700 LIQUID 3.50 g ORAL NDA 32 sections
healthy mamaBE WELL ROUNDED BE WELL ROUNDED HUMAN PRESCRIPTION DRUG LABEL 17 58154-107 TABLET, FILM COATED 30 mg ORAL unapproved drug other 8 sections
Zantanol Tab. HUMAN OTC DRUG LABEL 2 58354-101 TABLET 50 mg ORAL OTC monograph final 8 sections