carbamide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4264 57-13-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • urea
  • carbamide
  • carbamimidic acid
A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
  • Molecular weight: 60.06
  • Formula: CH4N2O
  • CLOGP: -1.66
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 69.11
  • ALOGS: 0.84
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 5, 1966 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC B05BC02 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
I.V. SOLUTIONS
Solutions producing osmotic diuresis
ATC D02AE01 DERMATOLOGICALS
EMOLLIENTS AND PROTECTIVES
EMOLLIENTS AND PROTECTIVES
Carbamide products
ATC D02AE51 DERMATOLOGICALS
EMOLLIENTS AND PROTECTIVES
EMOLLIENTS AND PROTECTIVES
Carbamide products
CHEBI has role CHEBI:64577 flour treatment agent
CHEBI has role CHEBI:33287 fertilizer

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Impacted cerumen indication 18070006
Atopic dermatitis indication 24079001 DOID:3310
Contact dermatitis indication 40275004 DOID:2773
Seborrheic dermatitis indication 50563003 DOID:8741
Pityriasis versicolor indication 56454009 DOID:9060
Pityriasis simplex indication 200767005
Eruption of skin indication 271807003 DOID:0050486
Acne vulgaris off-label use 88616000
Hyperkeratosis off-label use 396228006
Rosacea off-label use 398909004 DOID:8881
Injury of ear contraindication 2999009
Otalgia contraindication 16001004
Chronic purulent otitis media contraindication 38394007 DOID:14247
Perforation of tympanic membrane contraindication 60442001
Procedure on ear contraindication 118891001
Infection of ear contraindication 129127001
Irritation of ear contraindication 162360008
Itching of ear contraindication 699392007
Ear Redness contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.96 acidic
pKa2 13.39 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018430 VUID
N0000146756 NUI
C0041942 UMLSCUI
D00023 KEGG_DRUG
11002 RXNORM
16858004 SNOMEDCT_US
4018430 VANDF
9476 MMSL
387092000 SNOMEDCT_US
5656 MMSL
d04207 MMSL
002015 NDDF
002273 NDDF
8W8T17847W UNII
CHEMBL985 ChEMBL_ID
URE PDB_CHEM_ID
DB03904 DRUGBANK_ID
CHEBI:16199 CHEBI
D014508 MESH_DESCRIPTOR_UI
1176 PUBCHEM_CID
4539 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
GORDONS UREA 40 HUMAN PRESCRIPTION DRUG LABEL 1 10481-3005 OINTMENT 0.40 g TOPICAL unapproved drug other 5 sections
Urea Cream 40% HUMAN PRESCRIPTION DRUG LABEL 1 16477-340 CREAM 400 mg TOPICAL unapproved drug other 15 sections
Urea Cream 41% HUMAN PRESCRIPTION DRUG LABEL 1 16477-341 CREAM 410 mg TOPICAL unapproved drug other 15 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 42192-101 EMULSION 50 g TOPICAL unapproved drug other 13 sections
UREA HYDRATING TOPICAL HUMAN PRESCRIPTION DRUG LABEL 1 42192-115 AEROSOL, FOAM 35 g TOPICAL unapproved drug other 14 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 42291-849 CREAM 40 g TOPICAL unapproved drug other 13 sections
CEM-Urea HUMAN PRESCRIPTION DRUG LABEL 1 42546-100 SOLUTION 0.45 mL TOPICAL unapproved drug other 13 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 42792-101 CREAM 390 mg TOPICAL unapproved drug other 10 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 42808-202 CREAM 450 mg TOPICAL unapproved drug other 15 sections
Urea HUMAN PRESCRIPTION DRUG LABEL 1 42808-204 GEL 450 mg TOPICAL unapproved drug other 13 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 44523-617 CREAM 400 mg TOPICAL unapproved drug other 11 sections
Urea 47% Cream HUMAN PRESCRIPTION DRUG LABEL 1 50096-501 CREAM 470 mg TOPICAL unapproved drug other 11 sections
Urea HUMAN PRESCRIPTION DRUG LABEL 1 52191-351 CREAM 410 mg TOPICAL unapproved drug other 10 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 54295-308 CREAM 40 g TOPICAL unapproved drug other 12 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 54295-311 CREAM 39 g TOPICAL unapproved drug other 12 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 54295-312 LOTION 40 g TOPICAL unapproved drug other 12 sections
Keralac HUMAN PRESCRIPTION DRUG LABEL 1 57883-401 CREAM 470 mg TOPICAL unapproved drug other 11 sections
Utopic HUMAN PRESCRIPTION DRUG LABEL 1 57893-301 CREAM 410 mg TOPICAL unapproved drug other 10 sections
Urea 41 Percent HUMAN PRESCRIPTION DRUG LABEL 1 58657-486 CREAM 410 mg TOPICAL unapproved drug other 11 sections
Uremol HUMAN OTC DRUG LABEL 1 61344-452 LOTION 100 mg TOPICAL unapproved drug other 7 sections
Uremol 20% cream HUMAN OTC DRUG LABEL 1 61344-455 CREAM 200 mg TOPICAL unapproved drug other 7 sections
Umecta Mousse HUMAN PRESCRIPTION DRUG LABEL 1 68712-020 AEROSOL, FOAM 400 mg TOPICAL unapproved drug other 12 sections
Not Applicable HUMAN PRESCRIPTION DRUG LABEL 1 69336-810 CREAM 42 mg TOPICAL unapproved drug other 12 sections
URE-K HUMAN PRESCRIPTION DRUG LABEL 1 70350-2600 CREAM 500 mg TOPICAL UNAPPROVED DRUG OTHER 11 sections
URE-39 HUMAN PRESCRIPTION DRUG LABEL 1 70350-2612 CREAM 390 mg TOPICAL UNAPPROVED DRUG OTHER 11 sections
RYNODERM HUMAN PRESCRIPTION DRUG LABEL 1 70350-2626 CREAM 375 mg TOPICAL Unapproved drug other 11 sections
NOXIPAK HUMAN PRESCRIPTION DRUG LABEL 2 70350-5201 KIT 17 g None NDA authorized generic 16 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 71399-4528 GEL 0.45 mg TOPICAL unapproved drug other 10 sections
Umecta Mousse HUMAN PRESCRIPTION DRUG LABEL 1 71403-020 AEROSOL, FOAM 400 mg TOPICAL unapproved drug other 12 sections
Bare 20 HUMAN OTC DRUG LABEL 1 71718-001 GEL 20 g TOPICAL unapproved drug other 10 sections