Stem definition | Drug id | CAS RN |
---|---|---|
4264 | 57-13-6 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
Oct. 5, 1966 | FDA | HOSPIRA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Palmar-plantar erythrodysaesthesia syndrome | 90.55 | 23.47 | 31 | 1563 | 20067 | 50583463 |
Platelet count decreased | 25.86 | 23.47 | 23 | 1571 | 100703 | 50502827 |
Hypertension | 25.12 | 23.47 | 32 | 1562 | 211171 | 50392359 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Palmar-plantar erythrodysaesthesia syndrome | 121.16 | 24.61 | 41 | 1584 | 14718 | 29558184 |
Decreased appetite | 41.22 | 24.61 | 45 | 1580 | 145297 | 29427605 |
Hepatic encephalopathy | 34.49 | 24.61 | 16 | 1609 | 13019 | 29559883 |
Hepatocellular carcinoma | 29.65 | 24.61 | 12 | 1613 | 7026 | 29565876 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Palmar-plantar erythrodysaesthesia syndrome | 211.99 | 20.68 | 72 | 3146 | 28747 | 64466767 |
Decreased appetite | 46.01 | 20.68 | 63 | 3155 | 281226 | 64214288 |
Platelet count decreased | 44.46 | 20.68 | 48 | 3170 | 167663 | 64327851 |
Hepatic function abnormal | 42.64 | 20.68 | 31 | 3187 | 64282 | 64431232 |
Hepatic encephalopathy | 34.23 | 20.68 | 18 | 3200 | 21048 | 64474466 |
Hypertension | 33.52 | 20.68 | 52 | 3166 | 259209 | 64236305 |
Diarrhoea | 30.73 | 20.68 | 92 | 3126 | 722612 | 63772902 |
Hepatocellular carcinoma | 28.69 | 20.68 | 12 | 3206 | 8391 | 64487123 |
Colon cancer | 26.90 | 20.68 | 13 | 3205 | 12726 | 64482788 |
Dermatitis exfoliative | 26.28 | 20.68 | 12 | 3206 | 10340 | 64485174 |
Enterocolitis | 24.58 | 20.68 | 12 | 3206 | 12006 | 64483508 |
Blood bilirubin increased | 21.74 | 20.68 | 20 | 3198 | 57533 | 64437981 |
Malignant neoplasm progression | 21.03 | 20.68 | 27 | 3191 | 112844 | 64382670 |
None
Source | Code | Description |
---|---|---|
ATC | B05BC02 | BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS I.V. SOLUTIONS Solutions producing osmotic diuresis |
ATC | D02AE01 | DERMATOLOGICALS EMOLLIENTS AND PROTECTIVES EMOLLIENTS AND PROTECTIVES Carbamide products |
ATC | D02AE51 | DERMATOLOGICALS EMOLLIENTS AND PROTECTIVES EMOLLIENTS AND PROTECTIVES Carbamide products |
CHEBI has role | CHEBI:33287 | fertilizers |
CHEBI has role | CHEBI:64577 | dough improvers |
CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
CHEBI has role | CHEBI:75772 | S. cerevisiae metabolites |
CHEBI has role | CHEBI:76971 | Escherichia coli metabolites |
CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
CHEBI has role | CHEBI:83056 | Daphnia magna metabolites |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Impacted cerumen | indication | 18070006 | |
Atopic dermatitis | indication | 24079001 | DOID:3310 |
Contact dermatitis | indication | 40275004 | DOID:2773 |
Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
Pityriasis versicolor | indication | 56454009 | DOID:9060 |
Pityriasis simplex | indication | 200767005 | |
Eruption of skin | indication | 271807003 | DOID:0050486 |
Acne vulgaris | off-label use | 88616000 | |
Hyperkeratosis | off-label use | 396228006 | |
Rosacea | off-label use | 398909004 | DOID:8881 |
Injury of ear | contraindication | 2999009 | |
Otalgia | contraindication | 16001004 | |
Chronic purulent otitis media | contraindication | 38394007 | DOID:14247 |
Perforation of tympanic membrane | contraindication | 60442001 | |
Procedure on ear | contraindication | 118891001 | |
Infection of ear | contraindication | 129127001 | |
Irritation of ear | contraindication | 162360008 | |
Itching of ear | contraindication | 699392007 | |
Ear Redness | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 11.96 | acidic |
pKa2 | 13.39 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Olfactory receptor 51E2 | GPCR | EC50 | 7.64 | CHEMBL |
ID | Source |
---|---|
4018430 | VUID |
N0000146756 | NUI |
D00023 | KEGG_DRUG |
4018430 | VANDF |
C0041942 | UMLSCUI |
CHEBI:16199 | CHEBI |
URE | PDB_CHEM_ID |
CHEMBL985 | ChEMBL_ID |
DB03904 | DRUGBANK_ID |
4539 | IUPHAR_LIGAND_ID |
1176 | PUBCHEM_CID |
11002 | RXNORM |
5656 | MMSL |
9476 | MMSL |
d04207 | MMSL |
002015 | NDDF |
002273 | NDDF |
16858004 | SNOMEDCT_US |
387092000 | SNOMEDCT_US |
D014508 | MESH_DESCRIPTOR_UI |
8W8T17847W | UNII |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Urea Cream 40% | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7167 | CREAM | 400 mg | TOPICAL | unapproved drug other | 16 sections |
Urea Cream 40% | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16477-340 | CREAM | 400 mg | TOPICAL | unapproved drug other | 15 sections |
Urea Cream 41% | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16477-341 | CREAM | 410 mg | TOPICAL | unapproved drug other | 15 sections |
UREA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42192-101 | EMULSION | 50 g | TOPICAL | unapproved drug other | 14 sections |
UREA HYDRATING TOPICAL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42192-115 | AEROSOL, FOAM | 35 g | TOPICAL | unapproved drug other | 14 sections |
UREA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-849 | CREAM | 40 g | TOPICAL | unapproved drug other | 13 sections |
UREA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-849 | CREAM | 40 g | TOPICAL | unapproved drug other | 13 sections |
YouGreen F | HUMAN OTC DRUG LABEL | 1 | 42361-043 | OINTMENT | 7.50 g | TOPICAL | unapproved drug other | 9 sections |
CEM-Urea | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42546-100 | SOLUTION | 0.45 mL | TOPICAL | unapproved drug other | 13 sections |
UREA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42792-101 | CREAM | 390 mg | TOPICAL | unapproved drug other | 9 sections |
UREA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42808-202 | CREAM | 450 mg | TOPICAL | unapproved drug other | 15 sections |
Urea | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42808-204 | GEL | 450 mg | TOPICAL | unapproved drug other | 16 sections |
UREA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44523-617 | CREAM | 400 mg | TOPICAL | unapproved drug other | 12 sections |
Urea 47% Cream | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50096-501 | CREAM | 470 mg | TOPICAL | unapproved drug other | 11 sections |
UREA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52187-549 | CREAM | 470 mg | TOPICAL | unapproved drug other | 11 sections |
UREA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54295-308 | CREAM | 40 g | TOPICAL | unapproved drug other | 12 sections |
UREA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54295-311 | CREAM | 39 g | TOPICAL | unapproved drug other | 12 sections |
UREA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54295-312 | LOTION | 40 g | TOPICAL | unapproved drug other | 12 sections |
Urea 40 Percent | HUMAN PRESCRIPTION DRUG LABEL | 1 | 58657-487 | CREAM | 400 mg | TOPICAL | unapproved drug other | 16 sections |
Urea 41% | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59088-489 | CREAM | 410 mg | TOPICAL | unapproved drug other | 16 sections |
Uremol | HUMAN OTC DRUG LABEL | 1 | 61344-452 | LOTION | 100 mg | TOPICAL | unapproved drug other | 8 sections |
Uremol 20% cream | HUMAN OTC DRUG LABEL | 1 | 61344-455 | CREAM | 200 mg | TOPICAL | unapproved drug other | 7 sections |
Urea 41 Percent | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-1150 | CREAM | 410 mg | TOPICAL | unapproved drug other | 17 sections |
UREA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-2036 | CREAM | 39 g | TOPICAL | unapproved drug other | 13 sections |
UREA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-2036 | CREAM | 39 g | TOPICAL | unapproved drug other | 13 sections |
UREA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-2037 | CREAM | 40 g | TOPICAL | unapproved drug other | 13 sections |
UREA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-2037 | CREAM | 40 g | TOPICAL | unapproved drug other | 13 sections |
UREA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-2038 | CREAM | 40 g | TOPICAL | unapproved drug other | 13 sections |
UREA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-2038 | CREAM | 40 g | TOPICAL | unapproved drug other | 13 sections |
UREA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-2039 | CREAM | 40 g | TOPICAL | unapproved drug other | 13 sections |