methyl salicylate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4245 119-36-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methyl salicylate
  • analgit
  • methyl 2-hydroxybenzoate
  • methyl ester 2-hydroxy benzoic acid
used in over-the-counter liniments, ointments, lotions for relief of musculoskeletal aches and pains; has hemolytic effect on human & sheep erythrocytes; RN given refers to parent cpd; structure in Merck Index, 9th ed, #5990
  • Molecular weight: 152.15
  • Formula: C8H8O3
  • CLOGP: 2.34
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 46.53
  • ALOGS: -1.42
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 2008 FDA HISAMITSU PHARM CO

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Food intolerance 73.86 26.45 16 1202 2428 50601478
Injection site inflammation 69.54 26.45 16 1202 3189 50600717
Urosepsis 44.65 26.45 16 1202 15449 50588457
Nail bed tenderness 33.80 26.45 6 1212 323 50603583
Dyspepsia 32.72 26.45 21 1197 74076 50529830
Pruritus 31.04 26.45 36 1182 283532 50320374
Angioedema 30.93 26.45 16 1202 37660 50566246
Autonomic neuropathy 27.07 26.45 6 1212 1007 50602899

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Erythema multiforme 31.43 26.24 9 386 7708 29566424
Dermatitis exfoliative 28.45 26.24 8 387 6417 29567715

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Food intolerance 72.17 24.02 16 1475 2810 64494431
Injection site inflammation 70.08 24.02 16 1475 3205 64494036
Pruritus 50.71 24.02 48 1443 312352 64184889
Urosepsis 39.70 24.02 16 1475 22078 64475163
Nail bed tenderness 33.95 24.02 6 1485 328 64496913
Dyspepsia 31.92 24.02 21 1470 80291 64416950
Vulvovaginal swelling 27.52 24.02 5 1486 320 64496921
Autonomic neuropathy 24.39 24.02 6 1485 1646 64495595

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018501 Antirheumatic Agents
MeSH PA D005404 Fixatives
CHEBI has role CHEBI:24850 insect attractants
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:35617 flavouring agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Backache indication 161891005
Sprains and Strains indication
Arthritic Pain indication
Gastritis contraindication 4556007 DOID:4029
Bacterial septicemia contraindication 10001005 DOID:0040085
Shock contraindication 27942005
Gastrointestinal ulcer contraindication 40845000
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Factor II deficiency contraindication 73975000
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Decreased respiratory function contraindication 80954004
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Disorder of skin contraindication 95320005 DOID:37
Anemia due to enzyme deficiency contraindication 111577008
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Heart block contraindication 233916004
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Cardiovascular event risk contraindication 395112001
Breastfeeding (mother) contraindication 413712001
Denuded skin contraindication 418242004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.89 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019432 VUID
N0000147562 NUI
D01087 KEGG_DRUG
4019432 VANDF
C0066282 UMLSCUI
CHEBI:88839 CHEBI
CHEMBL108545 ChEMBL_ID
DB09543 DRUGBANK_ID
C033069 MESH_SUPPLEMENTAL_RECORD_UI
2431 IUPHAR_LIGAND_ID
LAV5U5022Y UNII
4133 PUBCHEM_CID
29787 RXNORM
5086 MMSL
6316 MMSL
001588 NDDF
001990 NDDF
111141006 SNOMEDCT_US
386988003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Theragesic Creme HUMAN OTC DRUG LABEL 2 0178-0320 GEL 150 mg TOPICAL OTC monograph not final 16 sections
Theragesic Plus HUMAN OTC DRUG LABEL 2 0178-0350 GEL 250 mg TOPICAL OTC monograph not final 15 sections
Antiseptic Mouth Rinse HUMAN OTC DRUG LABEL 4 0363-0072 MOUTHWASH 0.06 kg ORAL OTC monograph not final 12 sections
WALGREENS COOL AND HEAT MUSCLE AND JOINT RELIEF HUMAN OTC DRUG LABEL 2 0363-0147 CREAM 30 g TOPICAL OTC monograph not final 11 sections
WALGREENS MEDICATED PAIN RELIEVING HUMAN OTC DRUG LABEL 3 0363-0149 PATCH 36 mg TOPICAL OTC monograph not final 14 sections
Rinse HUMAN OTC DRUG LABEL 4 0363-0318 MOUTHWASH 0.60 mg ORAL OTC monograph not final 13 sections
Rinse HUMAN OTC DRUG LABEL 4 0363-0318 MOUTHWASH 0.60 mg ORAL OTC monograph not final 13 sections
Antispetic HUMAN OTC DRUG LABEL 4 0363-0664 MOUTHWASH 0.60 mg ORAL OTC monograph not final 14 sections
Antispetic HUMAN OTC DRUG LABEL 4 0363-0664 MOUTHWASH 0.60 mg ORAL OTC monograph not final 14 sections
Tartar control plus HUMAN OTC DRUG LABEL 4 0363-0855 MOUTHWASH 0.60 mg ORAL OTC monograph not final 13 sections
Pain Relief Patches HUMAN OTC DRUG LABEL 3 0363-0907 PATCH 10 g TOPICAL OTC monograph not final 11 sections
Walgreens Pain Relieving Analgesic HUMAN OTC DRUG LABEL 3 0363-1199 CREAM 300 mg TOPICAL OTC MONOGRAPH NOT FINAL 15 sections
Walgreens Cool n Heat HUMAN OTC DRUG LABEL 2 0363-9901 CREAM 300 mg TOPICAL OTC monograph not final 11 sections
Pain Relieving Patches HUMAN OTC DRUG LABEL 3 0363-9903 PATCH 6.30 1 TOPICAL OTC monograph not final 12 sections
Large Pain Relieving HUMAN OTC DRUG LABEL 3 0363-9904 PATCH 10 g TOPICAL OTC monograph not final 13 sections
Castiva Cooling HUMAN OTC DRUG LABEL 2 0395-0129 CREAM 140 mg TOPICAL OTC monograph not final 14 sections
Rugby Pain Relieving Analgesic HUMAN OTC DRUG LABEL 2 0536-1101 CREAM 150 mg TOPICAL OTC monograph not final 15 sections
Rugby Muscle Rub Cream HUMAN OTC DRUG LABEL 2 0536-1349 CREAM 150 mg TOPICAL OTC monograph not final 9 sections
Antiseptic HUMAN OTC DRUG LABEL 4 0869-0072 MOUTHWASH 0.60 mg ORAL OTC monograph not final 12 sections
Antiseptic Mouth Rinse HUMAN OTC DRUG LABEL 4 0869-0318 MOUTHWASH 0.60 mg ORAL OTC monograph not final 13 sections
Antiseptic Mouth Rinse HUMAN OTC DRUG LABEL 4 0869-0318 MOUTHWASH 0.60 mg ORAL OTC monograph not final 13 sections
Tartar Control Plus HUMAN OTC DRUG LABEL 4 0869-0434 MOUTHWASH 0.60 mg ORAL OTC monograph not final 12 sections
Tartar Control Plus HUMAN OTC DRUG LABEL 4 0869-0434 MOUTHWASH 0.60 mg ORAL OTC monograph not final 12 sections
Antispetic HUMAN OTC DRUG LABEL 4 0869-0664 MOUTHWASH 0.60 mg ORAL OTC monograph not final 12 sections
Antispetic HUMAN OTC DRUG LABEL 4 0869-0664 MOUTHWASH 0.60 mg ORAL OTC monograph not final 12 sections
foot worksarthritis achy foot and muscle HUMAN OTC DRUG LABEL 1 10096-0004 CREAM 250 mg TOPICAL OTC monograph not final 12 sections
Herb Street Sore Muscle Relief HUMAN OTC DRUG LABEL 1 10107-420 STICK 0.25 g TOPICAL OTC monograph not final 14 sections
Antispetic HUMAN OTC DRUG LABEL 4 10202-664 MOUTHWASH 0.60 mg ORAL OTC monograph not final 11 sections
Mentholatum Deep Heating RubExtra Strength HUMAN OTC DRUG LABEL 2 10742-2002 CREAM 300 mg TOPICAL OTC monograph not final 11 sections
Calorub HUMAN OTC DRUG LABEL 2 10742-2120 CREAM 128 mg TOPICAL Export only 1 sections