methyl salicylate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4245	119-36-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: methyl salicylate analgit methyl 2-hydroxybenzoate methyl ester 2-hydroxy benzoic acid	used in over-the-counter liniments, ointments, lotions for relief of musculoskeletal aches and pains; has hemolytic effect on human & sheep erythrocytes; RN given refers to parent cpd; structure in Merck Index, 9th ed, #5990 Molecular weight: 152.15 Formula: C8H8O3 CLOGP: 2.34 LIPINSKI: 0 HAC: 3 HDO: 1 TPSA: 46.53 ALOGS: -1.42 ROTB: 2 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

methyl salicylate
analgit
methyl 2-hydroxybenzoate
methyl ester 2-hydroxy benzoic acid

used in over-the-counter liniments, ointments, lotions for relief of musculoskeletal aches and pains; has hemolytic effect on human & sheep erythrocytes; RN given refers to parent cpd; structure in Merck Index, 9th ed, #5990

Molecular weight: 152.15
Formula: C8H8O3
CLOGP: 2.34
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 46.53
ALOGS: -1.42
ROTB: 2

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Feb. 20, 2008	FDA	HISAMITSU PHARM CO

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Food intolerance	99.67	24.46	25	3269	3300	63482428
Injection site inflammation	96.08	24.46	25	3269	3818	63481910
Urosepsis	60.80	24.46	26	3268	18498	63467230
Urticaria thermal	57.02	24.46	11	3283	428	63485300
Administration site erythema	45.35	24.46	10	3284	755	63484973
Hypercholesterolaemia	44.94	24.46	22	3272	21312	63464416
Angioedema	37.58	24.46	26	3268	47939	63437789
Pruritus	33.63	24.46	64	3230	361389	63124339
Nail bed tenderness	33.62	24.46	7	3287	402	63485326
Hypertension	33.10	24.46	55	3239	279248	63206480

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Anticholinergic syndrome	34.08	26.05	7	543	1262	34955119
Erythema multiforme	33.20	26.05	10	540	8639	34947742
Dermatitis exfoliative	31.28	26.05	9	541	6630	34949751
Bronchospasm	27.03	26.05	9	541	10722	34945659

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Food intolerance	104.13	24.86	25	2964	3823	79737576
Injection site inflammation	103.32	24.86	25	2964	3951	79737448
Pruritus	65.47	24.86	77	2912	394571	79346828
Urticaria thermal	60.44	24.86	11	2978	434	79740965
Urosepsis	59.99	24.86	26	2963	26469	79714930
Administration site erythema	55.81	24.86	10	2979	361	79741038
Angioedema	36.66	24.86	27	2962	76008	79665391
Nail bed tenderness	35.81	24.86	7	2982	407	79740992
Dyspepsia	34.09	24.86	30	2959	108657	79632742
Pigmentation disorder	32.74	24.86	11	2978	5607	79735792

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
CHEBI has role	CHEBI:24850	insect attractants
CHEBI has role	CHEBI:25212	metabolites
CHEBI has role	CHEBI:35617	flavouring agents
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D005404	Fixatives

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Backache	indication	161891005
Sprains and Strains	indication
Arthritic Pain	indication
Gastritis	contraindication	4556007	DOID:4029
Bacterial septicemia	contraindication	10001005	DOID:0040085
Shock	contraindication	27942005
Gastrointestinal ulcer	contraindication	40845000
Body fluid retention	contraindication	43498006
Conduction disorder of the heart	contraindication	44808001
Disorder of cardiovascular system	contraindication	49601007	DOID:1287

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.89	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
001588	NDDF
001990	NDDF
111141006	SNOMEDCT_US
2431	IUPHAR_LIGAND_ID
29787	RXNORM
386988003	SNOMEDCT_US
4019432	VUID
4019432	VANDF
4133	PUBCHEM_CID
5086	MMSL

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Antiseptic	HUMAN OTC DRUG LABEL	4	0869-0072	MOUTHWASH	0.60 mg	ORAL	OTC monograph not final	12 sections
Antiseptic	HUMAN OTC DRUG LABEL	4	0869-0072	MOUTHWASH	0.60 mg	ORAL	OTC monograph not final	12 sections
Antiseptic Mouth Rinse	HUMAN OTC DRUG LABEL	4	0363-0072	MOUTHWASH	0.60 mg	ORAL	OTC monograph not final	12 sections
Antiseptic Mouth Rinse	HUMAN OTC DRUG LABEL	4	0363-0072	MOUTHWASH	0.06 kg	ORAL	OTC monograph not final	12 sections
Antiseptic Mouth Rinse	HUMAN OTC DRUG LABEL	4	0869-0318	MOUTHWASH	0.60 mg	ORAL	OTC monograph not final	13 sections
Antiseptic Mouth Rinse	HUMAN OTC DRUG LABEL	4	0869-0318	MOUTHWASH	0.60 mg	ORAL	OTC monograph not final	13 sections
Antiseptic Mouth Rinse	HUMAN OTC DRUG LABEL	4	0869-0318	MOUTHWASH	0.60 mg	ORAL	OTC monograph not final	13 sections
Antispetic	HUMAN OTC DRUG LABEL	4	0363-0664	MOUTHWASH	0.60 mg	ORAL	OTC monograph not final	15 sections
Antispetic	HUMAN OTC DRUG LABEL	4	0363-0664	MOUTHWASH	0.60 mg	ORAL	OTC monograph not final	15 sections
Antispetic	HUMAN OTC DRUG LABEL	4	0363-0664	MOUTHWASH	0.60 mg	ORAL	OTC monograph not final	15 sections

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