methyl salicylate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4245 119-36-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methyl salicylate
  • analgit
  • methyl 2-hydroxybenzoate
  • methyl ester 2-hydroxy benzoic acid
used in over-the-counter liniments, ointments, lotions for relief of musculoskeletal aches and pains; has hemolytic effect on human & sheep erythrocytes; RN given refers to parent cpd; structure in Merck Index, 9th ed, #5990
  • Molecular weight: 152.15
  • Formula: C8H8O3
  • CLOGP: 2.34
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 46.53
  • ALOGS: -1.42
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 2008 FDA HISAMITSU PHARM CO

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Food intolerance 73.39 23.87 17 1679 2780 56287591
Injection site inflammation 70.01 23.87 17 1679 3399 56286972
Urosepsis 43.41 23.87 17 1679 16699 56273672
Nail bed tenderness 37.96 23.87 7 1689 372 56289999
Pruritus 33.16 23.87 44 1652 316579 55973792
Autonomic neuropathy 30.61 23.87 7 1689 1078 56289293
Angioedema 28.71 23.87 17 1679 41436 56248935
Dyspepsia 28.34 23.87 22 1674 83449 56206922
Vulvovaginal swelling 24.47 23.87 5 1691 454 56289917

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Erythema multiforme 34.74 28.59 10 448 8061 31688825
Dermatitis exfoliative 32.26 28.59 9 449 6483 31690403

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Food intolerance 72.35 23.45 17 1969 3181 70923277
Injection site inflammation 71.12 23.45 17 1969 3421 70923037
Pruritus 52.54 23.45 56 1930 345504 70580954
Urosepsis 38.70 23.45 17 1969 23932 70902526
Nail bed tenderness 38.37 23.45 7 1979 377 70926081
Dyspepsia 28.49 23.45 22 1964 89055 70837403
Autonomic neuropathy 27.85 23.45 7 1979 1728 70924730
Vulvovaginal swelling 26.25 23.45 5 1981 341 70926117
Dermatitis exfoliative 25.54 23.45 10 1976 10541 70915917
Angioedema 24.74 23.45 18 1968 66592 70859866

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018501 Antirheumatic Agents
MeSH PA D005404 Fixatives
CHEBI has role CHEBI:24850 insect attractants
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:35617 flavouring agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Backache indication 161891005
Sprains and Strains indication
Arthritic Pain indication
Gastritis contraindication 4556007 DOID:4029
Bacterial septicemia contraindication 10001005 DOID:0040085
Shock contraindication 27942005
Gastrointestinal ulcer contraindication 40845000
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Factor II deficiency contraindication 73975000
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Decreased respiratory function contraindication 80954004
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Disorder of skin contraindication 95320005 DOID:37
Anemia due to enzyme deficiency contraindication 111577008
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Heart block contraindication 233916004
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Cardiovascular event risk contraindication 395112001
Breastfeeding (mother) contraindication 413712001
Denuded skin contraindication 418242004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.89 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019432 VUID
N0000147562 NUI
D01087 KEGG_DRUG
4019432 VANDF
C0066282 UMLSCUI
CHEBI:88839 CHEBI
CHEMBL108545 ChEMBL_ID
DB09543 DRUGBANK_ID
C033069 MESH_SUPPLEMENTAL_RECORD_UI
2431 IUPHAR_LIGAND_ID
LAV5U5022Y UNII
4133 PUBCHEM_CID
29787 RXNORM
5086 MMSL
6316 MMSL
001588 NDDF
001990 NDDF
111141006 SNOMEDCT_US
386988003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Theragesic Creme HUMAN OTC DRUG LABEL 2 0178-0320 GEL 150 mg TOPICAL OTC monograph not final 16 sections
Theragesic Plus HUMAN OTC DRUG LABEL 2 0178-0350 GEL 250 mg TOPICAL OTC monograph not final 15 sections
Antiseptic Mouth Rinse HUMAN OTC DRUG LABEL 4 0363-0072 MOUTHWASH 0.06 kg ORAL OTC monograph not final 12 sections
WALGREENS COOL AND HEAT MUSCLE AND JOINT RELIEF HUMAN OTC DRUG LABEL 2 0363-0147 CREAM 30 g TOPICAL OTC monograph not final 11 sections
WALGREENS MEDICATED PAIN RELIEVING HUMAN OTC DRUG LABEL 3 0363-0149 PATCH 36 mg TOPICAL OTC monograph not final 14 sections
Rinse HUMAN OTC DRUG LABEL 4 0363-0318 MOUTHWASH 0.60 mg ORAL OTC monograph not final 13 sections
Rinse HUMAN OTC DRUG LABEL 4 0363-0318 MOUTHWASH 0.60 mg ORAL OTC monograph not final 13 sections
Antispetic HUMAN OTC DRUG LABEL 4 0363-0664 MOUTHWASH 0.60 mg ORAL OTC monograph not final 14 sections
Antispetic HUMAN OTC DRUG LABEL 4 0363-0664 MOUTHWASH 0.60 mg ORAL OTC monograph not final 14 sections
Tartar control plus HUMAN OTC DRUG LABEL 4 0363-0855 MOUTHWASH 0.60 mg ORAL OTC monograph not final 13 sections
Pain Relief Patches HUMAN OTC DRUG LABEL 3 0363-0907 PATCH 10 g TOPICAL OTC monograph not final 11 sections
Walgreens Pain Relieving Analgesic HUMAN OTC DRUG LABEL 3 0363-1199 CREAM 300 mg TOPICAL OTC MONOGRAPH NOT FINAL 15 sections
Walgreens Cool n Heat HUMAN OTC DRUG LABEL 2 0363-9901 CREAM 300 mg TOPICAL OTC monograph not final 11 sections
Pain Relieving Patches HUMAN OTC DRUG LABEL 3 0363-9903 PATCH 6.30 1 TOPICAL OTC monograph not final 12 sections
Large Pain Relieving HUMAN OTC DRUG LABEL 3 0363-9904 PATCH 10 g TOPICAL OTC monograph not final 13 sections
Castiva Cooling HUMAN OTC DRUG LABEL 2 0395-0129 CREAM 140 mg TOPICAL OTC monograph not final 14 sections
Rugby Pain Relieving Analgesic HUMAN OTC DRUG LABEL 2 0536-1101 CREAM 150 mg TOPICAL OTC monograph not final 15 sections
Rugby Muscle Rub Cream HUMAN OTC DRUG LABEL 2 0536-1349 CREAM 150 mg TOPICAL OTC monograph not final 9 sections
Antiseptic HUMAN OTC DRUG LABEL 4 0869-0072 MOUTHWASH 0.60 mg ORAL OTC monograph not final 12 sections
Antiseptic Mouth Rinse HUMAN OTC DRUG LABEL 4 0869-0318 MOUTHWASH 0.60 mg ORAL OTC monograph not final 13 sections
Antiseptic Mouth Rinse HUMAN OTC DRUG LABEL 4 0869-0318 MOUTHWASH 0.60 mg ORAL OTC monograph not final 13 sections
Tartar Control Plus HUMAN OTC DRUG LABEL 4 0869-0434 MOUTHWASH 0.60 mg ORAL OTC monograph not final 12 sections
Tartar Control Plus HUMAN OTC DRUG LABEL 4 0869-0434 MOUTHWASH 0.60 mg ORAL OTC monograph not final 12 sections
Antispetic HUMAN OTC DRUG LABEL 4 0869-0664 MOUTHWASH 0.60 mg ORAL OTC monograph not final 12 sections
Antispetic HUMAN OTC DRUG LABEL 4 0869-0664 MOUTHWASH 0.60 mg ORAL OTC monograph not final 12 sections
Tartar control plus HUMAN OTC DRUG LABEL 4 0869-0855 MOUTHWASH 0.60 mg ORAL OTC monograph not final 11 sections
foot worksarthritis achy foot and muscle HUMAN OTC DRUG LABEL 1 10096-0004 CREAM 250 mg TOPICAL OTC monograph not final 12 sections
Herb Street Sore Muscle Relief HUMAN OTC DRUG LABEL 1 10107-420 STICK 0.25 g TOPICAL OTC monograph not final 14 sections
Antispetic HUMAN OTC DRUG LABEL 4 10202-664 MOUTHWASH 0.60 mg ORAL OTC monograph not final 11 sections
Mentholatum Deep Heating RubExtra Strength HUMAN OTC DRUG LABEL 2 10742-2002 CREAM 300 mg TOPICAL OTC monograph not final 11 sections