All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

sodium fluoride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4243	7681-49-4

Description:

Molecule	Description
Synonyms: sodium fluoride sodium monofluoride	A source of inorganic fluoride which is used topically to prevent dental caries. Molecular weight: 41.99 Formula: FNa CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
1.10	mg	O
88	mg	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
July 11, 1997	FDA	COLGATE PALMOLIVE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Trifascicular block	23.46	20.38	4	2220	102	56289741

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory tract infection bacterial	80.07	24.41	18	1673	1448	31694205
Respiratory tract infection viral	74.38	24.41	18	1673	1996	31693657
Respiratory tract infection	51.70	24.41	23	1668	17538	31678115
Cytokine release syndrome	46.44	24.41	21	1670	16621	31679032
Eye infection	39.60	24.41	12	1679	3093	31692560
Somnambulism	36.28	24.41	11	1680	2841	31692812
Platelet count decreased	26.55	24.41	31	1660	110404	31585249
Sinusitis	26.23	24.41	19	1672	36677	31658976

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory tract infection bacterial	79.83	19.38	18	3210	1719	70923497
Respiratory tract infection viral	67.09	19.38	18	3210	3523	70921693
Cytokine release syndrome	52.11	19.38	25	3203	26442	70898774
Respiratory tract infection	33.54	19.38	22	3206	42376	70882840
Myelodysplastic syndrome	22.44	19.38	15	3213	29770	70895446
Trifascicular block	21.30	19.38	4	3224	154	70925062
Pulmonary embolism	20.44	19.38	30	3198	155837	70769379

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A01AA01	ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Caries prophylactic agents
ATC	A01AA51	ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Caries prophylactic agents
ATC	A12CD01	ALIMENTARY TRACT AND METABOLISM MINERAL SUPPLEMENTS OTHER MINERAL SUPPLEMENTS Fluoride
MeSH PA	D002327	Cariostatic Agents
MeSH PA	D020011	Protective Agents
CHEBI has role	CHEBI:25435	mutagens

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Vitamin deficiency	indication	85670002
Prevention of dental caries	indication	426482000
Gingivitis	off-label use	66383009	DOID:3087
Dental Plaque Prevention	off-label use
Constipation	contraindication	14760008	DOID:2089
Dental fluorosis	contraindication	30265004
Sarcoidosis	contraindication	31541009	DOID:11335
Dehydration	contraindication	34095006
Hypercalcemia	contraindication	66931009	DOID:12678
Hyperparathyroidism	contraindication	66999008	DOID:13543
Kidney disease	contraindication	90708001	DOID:557
Kidney stone	contraindication	95570007
Osteolysis	contraindication	203522001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
8ZYQ1474W7	UNII
4020179	VUID
N0000148121	NUI
D00943	KEGG_DRUG
4017647	VANDF
4017665	VANDF
4020179	VANDF
C0037508	UMLSCUI
CHEBI:28741	CHEBI
CHEMBL1528	ChEMBL_ID
5235	PUBCHEM_CID
DB09325	DRUGBANK_ID
D012969	MESH_DESCRIPTOR_UI
9873	RXNORM
1752	MMSL
4742	MMSL
5482	MMSL
001103	NDDF
329199009	SNOMEDCT_US
6910009	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Oral-B NeutraCare Mint	HUMAN PRESCRIPTION DRUG LABEL	1	0041-0241	GEL	11 mg	DENTAL	unapproved drug other	18 sections
Oral-B Minute-Foam Banana Splitz	HUMAN PRESCRIPTION DRUG LABEL	1	0041-0340	AEROSOL	10 mg	DENTAL	unapproved drug other	18 sections
Oral-B Minute-Foam Mellow Mint	HUMAN PRESCRIPTION DRUG LABEL	1	0041-0341	AEROSOL	10 mg	DENTAL	unapproved drug other	18 sections
Oral-B Minute-Foam Orang-A-Tangy	HUMAN PRESCRIPTION DRUG LABEL	2	0041-0342	AEROSOL	10 mg	DENTAL	unapproved drug other	18 sections
Oral-B Minute-Foam Bubble Gum	HUMAN PRESCRIPTION DRUG LABEL	1	0041-0345	AEROSOL	10 mg	DENTAL	unapproved drug other	18 sections
Oral-B Minute-Foam Strawberry	HUMAN PRESCRIPTION DRUG LABEL	1	0041-0346	AEROSOL	10 mg	DENTAL	unapproved drug other	18 sections
Oral-B Minute-Foam Grape Punch	HUMAN PRESCRIPTION DRUG LABEL	1	0041-0347	AEROSOL	10 mg	DENTAL	unapproved drug other	18 sections
Oral-B Neutra-Foam Mint	HUMAN PRESCRIPTION DRUG LABEL	1	0041-0348	AEROSOL	9 mg	DENTAL	unapproved drug other	18 sections
Oral-B Anticavity	HUMAN OTC DRUG LABEL	1	0041-1421	LIQUID	500 ug	DENTAL	OTC monograph not final	13 sections
PreviDent 5000 Dry Mouth	HUMAN PRESCRIPTION DRUG LABEL	1	0126-0016	GEL, DENTIFRICE	6.10 mg	DENTAL	UNAPPROVED DRUG OTHER	20 sections
PreviDent 5000 Enamel Protect	HUMAN PRESCRIPTION DRUG LABEL	2	0126-0022	GEL, DENTIFRICE	5.80 mg	DENTAL	UNAPPROVED DRUG OTHER	21 sections
PreviDent 5000 Enamel Protect	HUMAN PRESCRIPTION DRUG LABEL	2	0126-0022	GEL, DENTIFRICE	5.80 mg	DENTAL	UNAPPROVED DRUG OTHER	21 sections
Colgate Phos-Flur Ortho Defense Alcohol Free Anticavity Mint Fluoride	HUMAN OTC DRUG LABEL	1	0126-0032	RINSE	2 mg	DENTAL	OTC MONOGRAPH FINAL	11 sections
Colgate Phos-Flur Ortho Defense Alcohol Free Anticavity Mint Fluoride	HUMAN OTC DRUG LABEL	1	0126-0032	RINSE	2 mg	DENTAL	OTC MONOGRAPH FINAL	11 sections
PreviDent Alcohol Free	HUMAN PRESCRIPTION DRUG LABEL	1	0126-0033	MOUTHWASH	0.90 mg	DENTAL	UNAPPROVED DRUG OTHER	21 sections
PreviDent Alcohol Free	HUMAN PRESCRIPTION DRUG LABEL	1	0126-0033	MOUTHWASH	0.90 mg	DENTAL	UNAPPROVED DRUG OTHER	21 sections
Colgate Phos-Flur Ortho Defense Alcohol Free Anticavity Gushing Grape Fluoride	HUMAN OTC DRUG LABEL	1	0126-0034	RINSE	2 mg	DENTAL	OTC MONOGRAPH FINAL	11 sections
Colgate Phos-Flur Ortho Defense Alcohol Free Anticavity Gushing Grape Fluoride	HUMAN OTC DRUG LABEL	1	0126-0034	RINSE	2 mg	DENTAL	OTC MONOGRAPH FINAL	11 sections
PreviDent 5000 Sensitive	HUMAN PRESCRIPTION DRUG LABEL	2	0126-0070	GEL, DENTIFRICE	5.80 mg	DENTAL	UNAPPROVED DRUG OTHER	21 sections
PreviDent 5000 Sensitive	HUMAN PRESCRIPTION DRUG LABEL	2	0126-0070	GEL, DENTIFRICE	5.80 mg	DENTAL	UNAPPROVED DRUG OTHER	21 sections
PreviDent 5000 Booster Plus Fruitastic	HUMAN PRESCRIPTION DRUG LABEL	1	0126-0072	PASTE, DENTIFRICE	6 mg	DENTAL	UNAPPROVED DRUG OTHER	21 sections
PreviDent 5000 Booster Plus Fruitastic	HUMAN PRESCRIPTION DRUG LABEL	1	0126-0072	PASTE, DENTIFRICE	6 mg	DENTAL	UNAPPROVED DRUG OTHER	21 sections
PrevidDent 5000 Booster Plus Spearmint	HUMAN PRESCRIPTION DRUG LABEL	1	0126-0074	PASTE, DENTIFRICE	6 mg	DENTAL	UNAPPROVED DRUG OTHER	21 sections
PrevidDent 5000 Booster Plus Spearmint	HUMAN PRESCRIPTION DRUG LABEL	1	0126-0074	PASTE, DENTIFRICE	6 mg	DENTAL	UNAPPROVED DRUG OTHER	21 sections
PreviDent Fresh Mint	HUMAN PRESCRIPTION DRUG LABEL	1	0126-0088	GEL, DENTIFRICE	5 mg	DENTAL	UNAPPROVED DRUG OTHER	21 sections
PreviDent Fresh Mint	HUMAN PRESCRIPTION DRUG LABEL	1	0126-0088	GEL, DENTIFRICE	5 mg	DENTAL	UNAPPROVED DRUG OTHER	21 sections
PreviDent 5000 Plus Fruitastic	HUMAN PRESCRIPTION DRUG LABEL	1	0126-0286	PASTE, DENTIFRICE	5 mg	DENTAL	UNAPPROVED DRUG OTHER	21 sections
PreviDent 5000 Plus Fruitastic	HUMAN PRESCRIPTION DRUG LABEL	1	0126-0286	PASTE, DENTIFRICE	11 mg	DENTAL	UNAPPROVED DRUG OTHER	21 sections
PreviDent 5000 Plus Spearmint	HUMAN PRESCRIPTION DRUG LABEL	1	0126-0287	PASTE, DENTIFRICE	5 mg	DENTAL	UNAPPROVED DRUG OTHER	21 sections
PreviDent 5000 Plus Spearmint	HUMAN PRESCRIPTION DRUG LABEL	1	0126-0287	PASTE, DENTIFRICE	11 mg	DENTAL	UNAPPROVED DRUG OTHER	21 sections