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nitrous oxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4238 | 10024-97-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Subacute combined cord degeneration | 193.05 | 45.57 | 26 | 2132 | 215 | 90626074 |
| Choroidal infarction | 140.00 | 45.57 | 18 | 2140 | 99 | 90626190 |
| Hyperthermia malignant | 96.71 | 45.57 | 18 | 2140 | 1280 | 90625009 |
| Drug interaction | 95.90 | 45.57 | 67 | 2091 | 276386 | 90349903 |
| Leukoencephalopathy | 93.62 | 45.57 | 22 | 2136 | 4851 | 90621438 |
| Cardiac arrest | 88.01 | 45.57 | 45 | 2113 | 104890 | 90521399 |
| Lipodystrophy acquired | 81.62 | 45.57 | 16 | 2142 | 1498 | 90624791 |
| Vitamin B12 deficiency | 74.68 | 45.57 | 20 | 2138 | 7466 | 90618823 |
| Disinhibition | 61.94 | 45.57 | 12 | 2146 | 1056 | 90625233 |
| Gastrointestinal disorder congenital | 61.51 | 45.57 | 9 | 2149 | 141 | 90626148 |
| Bladder agenesis | 60.99 | 45.57 | 9 | 2149 | 150 | 90626139 |
| Genitalia external ambiguous | 60.60 | 45.57 | 9 | 2149 | 157 | 90626132 |
| Cloacal exstrophy | 60.60 | 45.57 | 9 | 2149 | 157 | 90626132 |
| Congenital genital malformation | 60.23 | 45.57 | 9 | 2149 | 164 | 90626125 |
| Gastrointestinal malformation | 58.40 | 45.57 | 9 | 2149 | 203 | 90626086 |
| Meconium stain | 58.31 | 45.57 | 9 | 2149 | 205 | 90626084 |
| Apnoea | 56.88 | 45.57 | 17 | 2141 | 9397 | 90616892 |
| Epilepsy with myoclonic-atonic seizures | 56.00 | 45.57 | 8 | 2150 | 105 | 90626184 |
| Congenital ectopic bladder | 56.00 | 45.57 | 8 | 2150 | 105 | 90626184 |
| Tethered cord syndrome | 55.46 | 45.57 | 9 | 2149 | 285 | 90626004 |
| Brain oedema | 54.20 | 45.57 | 19 | 2139 | 17366 | 90608923 |
| Anal atresia | 51.63 | 45.57 | 9 | 2149 | 441 | 90625848 |
| Caudal regression syndrome | 51.47 | 45.57 | 8 | 2150 | 191 | 90626098 |
| Ventricular tachycardia | 51.20 | 45.57 | 20 | 2138 | 24688 | 90601601 |
| Neural tube defect | 51.12 | 45.57 | 8 | 2150 | 200 | 90626089 |
| Meningomyelocele | 48.44 | 45.57 | 9 | 2149 | 633 | 90625656 |
| Myelopathy | 47.95 | 45.57 | 12 | 2146 | 3432 | 90622857 |
| Umbilical cord abnormality | 47.89 | 45.57 | 9 | 2149 | 673 | 90625616 |
| Ventricular fibrillation | 46.28 | 45.57 | 16 | 2142 | 14028 | 90612261 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Subacute combined cord degeneration | 381.55 | 42.01 | 49 | 2034 | 106 | 42619146 |
| Choroidal infarction | 139.11 | 42.01 | 19 | 2064 | 76 | 42619176 |
| Hyperthermia malignant | 91.15 | 42.01 | 22 | 2061 | 2636 | 42616616 |
| Vitamin B12 deficiency | 86.85 | 42.01 | 24 | 2059 | 4898 | 42614354 |
| Myelopathy | 84.28 | 42.01 | 21 | 2062 | 2870 | 42616382 |
| Substance use | 78.44 | 42.01 | 18 | 2065 | 1733 | 42617519 |
| Drug abuse | 74.19 | 42.01 | 52 | 2031 | 104719 | 42514533 |
| Anaesthetic complication | 65.38 | 42.01 | 15 | 2068 | 1442 | 42617810 |
| Hyperhomocysteinaemia | 55.98 | 42.01 | 10 | 2073 | 270 | 42618982 |
| Drug use disorder | 54.18 | 42.01 | 20 | 2063 | 10313 | 42608939 |
| Laryngospasm | 45.93 | 42.01 | 12 | 2071 | 1976 | 42617276 |
| Drug dependence | 45.37 | 42.01 | 24 | 2059 | 29070 | 42590182 |
| Gas poisoning | 44.32 | 42.01 | 7 | 2076 | 87 | 42619165 |
| Cardiac arrest | 44.14 | 42.01 | 39 | 2044 | 109281 | 42509971 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Subacute combined cord degeneration | 521.58 | 34.29 | 69 | 3943 | 299 | 110584988 |
| Choroidal infarction | 275.69 | 34.29 | 37 | 3975 | 182 | 110585105 |
| Vitamin B12 deficiency | 157.92 | 34.29 | 42 | 3970 | 10013 | 110575274 |
| Hyperthermia malignant | 147.20 | 34.29 | 33 | 3979 | 3867 | 110581420 |
| Myelopathy | 135.46 | 34.29 | 33 | 3979 | 5543 | 110579744 |
| Cardiac arrest | 123.58 | 34.29 | 81 | 3931 | 196672 | 110388615 |
| Substance use | 98.91 | 34.29 | 22 | 3990 | 2484 | 110582803 |
| Drug abuse | 96.86 | 34.29 | 67 | 3945 | 177344 | 110407943 |
| Anaesthetic complication | 90.94 | 34.29 | 22 | 3990 | 3584 | 110581703 |
| Drug interaction | 81.16 | 34.29 | 95 | 3917 | 500088 | 110085199 |
| Drug use disorder | 77.87 | 34.29 | 28 | 3984 | 18046 | 110567241 |
| Bradycardia | 76.19 | 34.29 | 55 | 3957 | 155462 | 110429825 |
| Laryngospasm | 70.90 | 34.29 | 19 | 3993 | 4649 | 110580638 |
| Leukoencephalopathy | 70.55 | 34.29 | 22 | 3990 | 9173 | 110576114 |
| Hyperhomocysteinaemia | 68.77 | 34.29 | 13 | 3999 | 654 | 110584633 |
| Drug dependence | 61.76 | 34.29 | 32 | 3980 | 49988 | 110535299 |
| Vitamin B12 decreased | 59.56 | 34.29 | 17 | 3995 | 5240 | 110580047 |
| Ventricular tachycardia | 58.91 | 34.29 | 31 | 3981 | 49978 | 110535309 |
| Neuromuscular block prolonged | 55.03 | 34.29 | 12 | 4000 | 1235 | 110584052 |
| Delayed recovery from anaesthesia | 53.22 | 34.29 | 13 | 3999 | 2202 | 110583085 |
| Epilepsy with myoclonic-atonic seizures | 52.41 | 34.29 | 8 | 4004 | 108 | 110585179 |
| Apnoea | 50.85 | 34.29 | 19 | 3993 | 13620 | 110571667 |
| Blood homocysteine increased | 47.52 | 34.29 | 9 | 4003 | 457 | 110584830 |
| Substance abuser | 47.31 | 34.29 | 9 | 4003 | 468 | 110584819 |
| Ventricular fibrillation | 46.92 | 34.29 | 25 | 3987 | 41288 | 110543999 |
| Gas poisoning | 46.18 | 34.29 | 7 | 4005 | 90 | 110585197 |
| Toxicity to various agents | 45.09 | 34.29 | 70 | 3942 | 480485 | 110104802 |
| Agitation | 44.26 | 34.29 | 35 | 3977 | 113016 | 110472271 |
| Disinhibition | 44.04 | 34.29 | 12 | 4000 | 3122 | 110582165 |
| Substance dependence | 43.55 | 34.29 | 9 | 4003 | 716 | 110584571 |
| Neuromuscular blockade | 43.32 | 34.29 | 9 | 4003 | 735 | 110584552 |
| Ataxia | 42.22 | 34.29 | 21 | 3991 | 30087 | 110555200 |
| Dystonia | 42.22 | 34.29 | 20 | 3992 | 25785 | 110559502 |
| Brain oedema | 41.58 | 34.29 | 21 | 3991 | 31077 | 110554210 |
| Pulmonary oedema | 41.21 | 34.29 | 32 | 3980 | 100627 | 110484660 |
| Air embolism | 38.77 | 34.29 | 8 | 4004 | 632 | 110584655 |
| Polyneuropathy | 38.13 | 34.29 | 20 | 3992 | 31992 | 110553295 |
| Sinus tachycardia | 37.14 | 34.29 | 22 | 3990 | 44471 | 110540816 |
| Change in seizure presentation | 36.66 | 34.29 | 8 | 4004 | 826 | 110584461 |
| Neuropathy vitamin B12 deficiency | 34.66 | 34.29 | 6 | 4006 | 183 | 110585104 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N01AX13 | NERVOUS SYSTEM ANESTHETICS ANESTHETICS, GENERAL Other general anesthetics |
| ATC | N01AX63 | NERVOUS SYSTEM ANESTHETICS ANESTHETICS, GENERAL Other general anesthetics |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000777 | Anesthetics |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D018685 | Anesthetics, Inhalation |
| MeSH PA | D018689 | Sensory System Agents |
| MeSH PA | D018712 | Analgesics, Non-Narcotic |
| CHEBI has role | CHEBI:35480 | analgesic |
| CHEBI has role | CHEBI:35620 | vasodilator agent |
| CHEBI has role | CHEBI:38869 | general anaesthetic |
| CHEBI has role | CHEBI:38870 | inhalation anaesthetic |
| CHEBI has role | CHEBI:60643 | NMDA receptor antagonist |
| CHEBI has role | CHEBI:76413 | greenhouse gas |
| CHEBI has role | CHEBI:76969 | bacterial metabolite |
| CHEBI has role | CHEBI:77971 | raising agent |
| CHEBI has role | CHEBI:77974 | food packaging gas |
| CHEBI has role | CHEBI:78017 | food propellant |
| CHEBI has role | CHEBI:78433 | refrigerant |
| CHEBI has role | CHEBI:35469 | antidepressant |
| CHEBI has role | CHEBI:35474 | anxiolytic drug |
| CHEBI has role | CHEBI:35476 | antipsychotic agent |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:73336 | vulnerary |
| CHEBI has role | CHEBI:75835 | anti-anaemic agent |
Related Drugs by ATC class:
N01AX Other general anesthetics 8 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| None (Med Gas) | Air Liquide America Specialty Gases | 2 |
| None (Med Gas) | Nitrous Oxide Corp | 2 |
| None (Med Gas) | Nitrous Oxide of Canada | 2 |
| None (Med Gas) | Strata Medical Innovations | 2 |
| None (Med Gas) | Praxair Mexico, S. de R.L. de C.V. | 2 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| K50XQU1029 | UNII |
| 4019137 | VUID |
| N0000147387 | NUI |
| D00102 | KEGG_DRUG |
| 4019137 | VANDF |
| C0028215 | UMLSCUI |
| CHEBI:17045 | CHEBI |
| N2O | PDB_CHEM_ID |
| CHEMBL1234579 | ChEMBL_ID |
| 948 | PUBCHEM_CID |
| DB06690 | DRUGBANK_ID |
| D009609 | MESH_DESCRIPTOR_UI |
| 7486 | RXNORM |
| d00934 | MMSL |
| 001387 | NDDF |
| 111132001 | SNOMEDCT_US |
| 388185005 | SNOMEDCT_US |
| K50XQU1029 | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10014-003 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10014-003 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| NITROUS OXIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10167-200 | GAS | 99 L | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10678-006 | GAS | 992 mL | RESPIRATORY (INHALATION) | unapproved medical gas | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10736-017 | GAS | 995 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| NITROUS OXIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10927-102 | GAS | 99 L | RESPIRATORY (INHALATION) | NDA | 1 sections |
| NITROUS OXIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 11054-007 | GAS | 992 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| NITROUS OXIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12121-002 | GAS | 99 L | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12213-593 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12213-593 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17575-011 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17575-011 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 18482-002 | GAS | 995 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 20703-003 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 20703-003 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21220-122 | GAS | 995 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 22557-003 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 22557-003 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| NITROUS OXIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24312-003 | GAS | 99 L | RESPIRATORY (INHALATION) | NDA | 1 sections |
| NITROUS OXIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24312-003 | GAS | 99 L | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25543-012 | GAS | 990 mL | RESPIRATORY (INHALATION) | unapproved medical gas | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33335-003 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33344-003 | GAS | 99 L | RESPIRATORY (INHALATION) | unapproved medical gas | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33344-004 | LIQUID | 99 L | RESPIRATORY (INHALATION) | unapproved medical gas | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 34057-010 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| NITROUS OXIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 34330-003 | GAS | 99 L | RESPIRATORY (INHALATION) | unapproved medical gas | 2 sections |
| NITROUS OXIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42602-003 | GAS | 99 L | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42751-1070 | GAS | 99 L | RESPIRATORY (INHALATION) | unapproved medical gas | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42751-1075 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43621-003 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |