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Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	2302	2078-54-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: propofol ampofol diprivan disoprofol pofol	An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS. Molecular weight: 178.28 Formula: C12H18O CLOGP: 3.93 LIPINSKI: 0 HAC: 1 HDO: 1 TPSA: 20.23 ALOGS: -3.05 ROTB: 2 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

propofol
ampofol
diprivan
disoprofol
pofol

An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.

Molecular weight: 178.28
Formula: C12H18O
CLOGP: 3.93
LIPINSKI: 0
HAC: 1
HDO: 1
TPSA: 20.23
ALOGS: -3.05
ROTB: 2

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.16 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	14.02 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	4.70 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	36 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.02 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	3.20 hours	Lombardo F, Berellini G, Obach RS
BA (Bioavailability)	4 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
azlogd74	LogD at pH 7.4	3.713		Moderate	0.73
caco2-efflux	Caco-2 efflux ratio (BA/AB)	0.729		Moderate	0.73
caco2-intrinsic-papp	Caco-2 intrinsic apparent permeability	60.814	10^-6 cm/s	Moderate	0.73
dh-clint	Dog hepatocyte intrinsic clearance	11.722	uL/min/10^6 cells	Moderate	0.73
dppb	Dog plasma protein binding (% unbound)	8.570	%	Moderate	0.73
fcs-ppb	Fetal calf serum protein binding (% unbound)	6.650	%	Moderate	0.73
herg	hERG pIC50	4.690	pIC50	Moderate	0.73
hh-clint	Human hepatocyte intrinsic clearance	83.368	uL/min/10^6 cells	Moderate	0.73
hlm-clint	Human liver microsomal intrinsic clearance	114.551	uL/min/mg protein	Moderate	0.73
hppb	Human plasma protein binding (% unbound)	5.770	%	Moderate	0.73
kinase-safety-class	ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K1,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70	59
kinase-selectivity-class	AXL,BRAF,CSF1R,DDR1,EPHB4,GRK2,PDK4	7
mdck-mdr1-efflux	MDCK-MDR1 efflux ratio	0.133		Moderate	0.73
mh-clint	Mouse hepatocyte intrinsic clearance	292.415		Moderate	0.73
mppb	Mouse plasma protein binding (% unbound)	6.780		Moderate	0.73
nih-mdck-mdr1-efflux	NIH MDCK-MDR1 efflux ratio	0.166		Moderate	0.73
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pppb	Pig plasma protein binding (% unbound)	5.670	%	Moderate	0.73
rh-clint	Rat hepatocyte intrinsic clearance	103.276	uL/min/10^6 cells	Moderate	0.73
rh-fuinc	Rat hepatocyte fraction unbound in incubation	34.990	%	Moderate	0.73
rppb	Rat plasma protein binding (% unbound)	9.220	%	Moderate	0.73
solubility-dd	Solubility at pH 7.4 in DMSO	1.968	uM	Moderate	0.73

Approvals:

Date	Agency	Company	Orphan
Oct. 2, 1989	FDA	FRESENIUS KABI USA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Anaphylactic shock	4051.71	17.12	1232	48516	30385	90548314
Anaphylactic reaction	1652.48	17.12	852	48896	86672	90492027
Hypotension	1380.22	17.12	1254	48494	324143	90254556
Cardiac arrest	1196.23	17.12	734	49014	104201	90474498
Bronchospasm	1026.47	17.12	397	49351	20312	90558387
Propofol infusion syndrome	1018.45	17.12	217	49531	1122	90577577
Serotonin syndrome	592.92	17.12	326	49422	37561	90541138
Tachycardia	529.94	17.12	536	49212	157137	90421562
Delayed recovery from anaesthesia	529.00	17.12	121	49627	909	90577790
Stress cardiomyopathy	525.93	17.12	217	49531	13138	90565561
Bradycardia	510.03	17.12	399	49349	83448	90495251
Circulatory collapse	499.54	17.12	253	49495	24651	90554048
Drug interaction	415.14	17.12	626	49122	275827	90302872
Status epilepticus	414.69	17.12	204	49544	18670	90560029
Hyperthermia malignant	390.29	17.12	99	49649	1199	90577500
Respiratory depression	377.32	17.12	180	49568	15395	90563304
Multiple organ dysfunction syndrome	339.23	17.12	289	49459	68047	90510652
Fatigue	335.43	17.12	109	49639	1153914	89424785
Oxygen saturation decreased	317.03	17.12	341	49407	107142	90471557
Ventricular tachycardia	314.89	17.12	186	49562	24522	90554177
Arthralgia	298.92	17.12	38	49710	778484	89800215
Haemodynamic instability	294.54	17.12	139	49609	11600	90567099
Ventricular fibrillation	291.32	17.12	146	49602	13898	90564801
Anaesthetic complication neurological	275.44	17.12	67	49681	674	90578025
Neuromuscular block prolonged	273.52	17.12	65	49683	587	90578112
Metabolic acidosis	271.26	17.12	233	49515	55443	90523256
Procedural hypotension	259.48	17.12	75	49673	1525	90577174
Shock	257.12	17.12	173	49575	28605	90550094
Joint swelling	256.08	17.12	4	49744	503296	90075403
Blood pressure decreased	246.47	17.12	252	49496	74643	90504056
Unwanted awareness during anaesthesia	242.20	17.12	54	49694	356	90578343
Rhabdomyolysis	238.57	17.12	209	49539	51047	90527652
Apnoea	234.73	17.12	111	49637	9303	90569396
Myoclonus	230.45	17.12	139	49609	19029	90559670
Diarrhoea	229.63	17.12	115	49633	939075	89639624
Alopecia	226.16	17.12	11	49737	495060	90083639
Myoglobin urine present	213.79	17.12	55	49693	707	90577992
Pulseless electrical activity	212.58	17.12	102	49646	8830	90569869
Drug intolerance	210.87	17.12	8	49740	447583	90131116
Anaesthetic complication	203.69	17.12	69	49679	2396	90576303
Dystonia	202.28	17.12	122	49626	16697	90562002
Cardio-respiratory arrest	194.33	17.12	205	49543	62935	90515764
Blood creatine phosphokinase increased	193.99	17.12	156	49592	33867	90544832
Hypoxia	189.72	17.12	216	49532	72183	90506516
Acute generalised exanthematous pustulosis	184.71	17.12	107	49641	13596	90565103
Abdominal discomfort	183.64	17.12	23	49725	477305	90101394
Nasopharyngitis	179.80	17.12	11	49737	407093	90171606
Respiratory acidosis	179.03	17.12	88	49660	8031	90570668
Diabetes insipidus	178.53	17.12	67	49681	3145	90575554
Maternal exposure during delivery	177.25	17.12	70	49678	3776	90574923
Systemic lupus erythematosus	175.62	17.12	5	49743	361891	90216808
Type I hypersensitivity	172.01	17.12	70	49678	4085	90574614
Multiple-drug resistance	170.62	17.12	84	49664	7692	90571007
Premature delivery	170.29	17.12	153	49595	38609	90540090
Arthropathy	167.62	17.12	8	49740	366234	90212465
Infusion related reaction	165.47	17.12	18	49730	416762	90161937
Generalised tonic-clonic seizure	163.75	17.12	143	49605	34760	90543939
Glossodynia	161.71	17.12	3	49745	321776	90256923
Weight increased	161.06	17.12	20	49728	417907	90160792
Respiratory failure	160.28	17.12	256	49492	118162	90460537
Rheumatoid arthritis	159.50	17.12	10	49738	362604	90216095
Pain	159.46	17.12	188	49560	996153	89582546
Sinusitis	155.39	17.12	8	49740	343080	90235619
Airway complication of anaesthesia	154.82	17.12	38	49710	398	90578301
Peripheral swelling	153.86	17.12	22	49726	413084	90165615
Electrocardiogram ST segment elevation	153.82	17.12	64	49684	3952	90574747
Post procedural complication	152.43	17.12	107	49641	18935	90559764
Anaphylactoid shock	149.60	17.12	37	49711	401	90578298
Unresponsive to stimuli	149.07	17.12	141	49607	37980	90540719
Headache	148.75	17.12	153	49595	862593	89716106
Fall	145.69	17.12	42	49706	481768	90096931
Torsade de pointes	144.60	17.12	95	49653	15087	90563612
Labile blood pressure	144.31	17.12	50	49698	1860	90576839
Malaise	144.03	17.12	71	49677	585915	89992784
Drug ineffective for unapproved indication	143.60	17.12	180	49568	66464	90512235
Toxic encephalopathy	141.92	17.12	77	49671	8622	90570077
Swelling	141.38	17.12	29	49719	419029	90159670
Cardiogenic shock	141.20	17.12	113	49635	24355	90554344
Laryngospasm	140.88	17.12	57	49691	3276	90575423
Hypoventilation	136.82	17.12	64	49684	5232	90573467
Agitation	136.31	17.12	176	49572	66922	90511777
Anaphylactoid reaction	134.32	17.12	60	49688	4408	90574291
Wound	131.31	17.12	9	49739	302971	90275728
Seizure	128.92	17.12	269	49479	152360	90426339
Electrocardiogram QT prolonged	128.72	17.12	178	49570	72278	90506421
Mydriasis	128.71	17.12	88	49660	14924	90563775
Amylase increased	127.76	17.12	67	49681	7005	90571694
Anticholinergic syndrome	126.67	17.12	50	49698	2693	90576006
Clonus	125.81	17.12	62	49686	5688	90573011
Procedural complication	121.57	17.12	61	49687	5817	90572882
Arteriospasm coronary	121.17	17.12	58	49690	4992	90573707
Stridor	120.98	17.12	57	49691	4736	90573963
Lower respiratory tract infection	119.62	17.12	4	49744	250655	90328044
Pain in extremity	119.38	17.12	49	49699	450480	90128219
Respiratory arrest	114.85	17.12	115	49633	33196	90545503
Kounis syndrome	112.53	17.12	45	49703	2508	90576191
Contraindicated product administered	112.51	17.12	20	49728	320119	90258580
Tryptase increased	111.96	17.12	31	49717	536	90578163
Stomatitis	111.19	17.12	11	49737	274687	90304012
Pruritus	110.12	17.12	82	49666	541443	90037256
Product dose omission issue	109.81	17.12	15	49733	291672	90287027
Encephalopathy	109.02	17.12	131	49617	46313	90532386
Musculoskeletal stiffness	107.58	17.12	17	49731	296515	90282184
Contusion	107.29	17.12	8	49740	251208	90327491
Allergy test negative	106.60	17.12	25	49723	212	90578487
Intra-abdominal pressure increased	106.57	17.12	26	49722	265	90578434
Dizziness	105.41	17.12	101	49647	589183	89989516
Mitochondrial DNA mutation	104.22	17.12	28	49720	430	90578269
Hepatic enzyme increased	100.91	17.12	36	49712	360700	90217999
Disseminated intravascular coagulation	100.53	17.12	88	49660	21450	90557249
Brain oedema	99.69	17.12	80	49668	17305	90561394
Sinus tachycardia	99.33	17.12	99	49649	28414	90550285
Opisthotonus	99.21	17.12	26	49722	361	90578338
Pulmonary oedema	99.18	17.12	145	49603	61935	90516764
Exposure during pregnancy	98.25	17.12	321	49427	238089	90340610
Anaesthetic complication pulmonary	97.10	17.12	19	49729	58	90578641
Laryngeal oedema	96.11	17.12	55	49693	6826	90571873
Troponin increased	95.67	17.12	70	49678	13211	90565488
Intestinal ischaemia	95.51	17.12	60	49688	8823	90569876
Myocardial depression	95.26	17.12	28	49720	605	90578094
Gastrointestinal disorder	94.74	17.12	14	49734	256673	90322026
Angioedema	94.32	17.12	145	49603	64731	90513968
PCO2 increased	93.92	17.12	33	49715	1280	90577419
Renal ischaemia	93.85	17.12	28	49720	638	90578061
Posterior reversible encephalopathy syndrome	93.83	17.12	86	49662	22253	90556446
Weight decreased	93.28	17.12	46	49702	379864	90198835
Discomfort	92.43	17.12	19	49729	274316	90304383
Insomnia	92.04	17.12	34	49714	333440	90245259
Ventricular hypokinesia	91.95	17.12	49	49699	5292	90573407
Nausea	91.50	17.12	309	49439	1110007	89468692
Impaired healing	90.65	17.12	11	49737	234188	90344511
Phaeochromocytoma crisis	90.55	17.12	24	49724	349	90578350
Electrocardiogram QRS complex prolonged	90.15	17.12	54	49694	7294	90571405
Dyspnoea	89.44	17.12	222	49526	880733	89697966
Blood gases abnormal	88.95	17.12	29	49719	892	90577807
Coma	88.75	17.12	150	49598	72482	90506217
Tracheal deviation	87.68	17.12	22	49726	254	90578445
Phrenic nerve paralysis	87.26	17.12	23	49725	327	90578372
Oculogyric crisis	86.58	17.12	37	49711	2442	90576257
Oliguria	85.72	17.12	60	49688	10564	90568135
Acute hepatic failure	85.44	17.12	82	49666	22479	90556220
Transmission of an infectious agent via product	84.98	17.12	19	49729	127	90578572
Decreased appetite	84.57	17.12	51	49697	376489	90202210
Acute respiratory distress syndrome	84.44	17.12	91	49657	28595	90550104
Infection	84.22	17.12	47	49701	362047	90216652
Coagulopathy	83.23	17.12	82	49666	23207	90555492
Partial seizures	83.02	17.12	51	49697	7209	90571490
Blood lactate dehydrogenase increased	82.97	17.12	86	49662	25846	90552853
Electrocardiogram ST segment depression	82.50	17.12	39	49709	3264	90575435
Erythema	82.46	17.12	295	49453	228951	90349748
Hepatocellular injury	81.99	17.12	90	49658	28868	90549831
Product contamination	81.81	17.12	29	49719	1155	90577544
Hypercapnia	81.74	17.12	49	49699	6628	90572071
Mobility decreased	81.15	17.12	19	49729	250715	90327984
Drug ineffective	79.28	17.12	1129	48619	1383169	89195530
Hypertriglyceridaemia	79.13	17.12	51	49697	7838	90570861
Fibromyalgia	79.07	17.12	10	49738	206259	90372440
Arthritis	78.66	17.12	3	49745	167312	90411387
Septic shock	77.74	17.12	154	49594	84006	90494693
Renal failure	77.68	17.12	201	49547	130806	90447893
Acute pulmonary oedema	77.05	17.12	54	49694	9526	90569173
Hepatic ischaemia	76.96	17.12	25	49723	760	90577939
Necrosis ischaemic	74.99	17.12	26	49722	969	90577730
Depressed level of consciousness	74.35	17.12	139	49609	72645	90506054
Hyperreflexia	74.18	17.12	46	49702	6611	90572088
Hepatic failure	74.16	17.12	100	49648	39628	90539071
Ill-defined disorder	73.26	17.12	8	49740	184883	90393816
Alanine aminotransferase increased	72.68	17.12	184	49564	118154	90460545
Blood pH decreased	72.60	17.12	33	49715	2525	90576174
Postoperative delirium	72.53	17.12	18	49730	198	90578501
CSF oligoclonal band present	72.51	17.12	21	49727	430	90578269
Toxicity to various agents	72.08	17.12	331	49417	287515	90291184
Abdominal pain upper	72.01	17.12	47	49701	332627	90246072
Muscle rigidity	71.92	17.12	61	49687	14248	90564451
Muscle injury	71.65	17.12	7	49741	176647	90402052
Pneumatosis	71.60	17.12	21	49727	450	90578249
Altered state of consciousness	70.84	17.12	87	49661	31445	90547254
Vasoplegia syndrome	69.59	17.12	33	49715	2781	90575918
Airway peak pressure increased	69.59	17.12	20	49728	398	90578301
Dyskinesia	68.25	17.12	92	49656	36442	90542257
Endotracheal intubation complication	68.09	17.12	20	49728	431	90578268
Neuromuscular blockade	67.64	17.12	19	49729	347	90578352
Blood lactic acid increased	67.18	17.12	48	49700	8730	90569969
Toxic epidermal necrolysis	67.10	17.12	86	49662	32442	90546257
Carcinoid crisis	66.78	17.12	18	49730	280	90578419
Hepatorenal syndrome	66.39	17.12	29	49719	2019	90576680
Asthma	66.27	17.12	25	49723	242135	90336564
PO2 increased	66.04	17.12	23	49725	869	90577830
Ventricular extrasystoles	65.60	17.12	56	49692	13194	90565505
Renal impairment	64.82	17.12	164	49584	105257	90473442
Gait disturbance	64.73	17.12	31	49717	260465	90318234
Hepatitis acute	64.34	17.12	51	49697	10836	90567863
Dyspepsia	64.15	17.12	15	49733	198145	90380554
Recurrence of neuromuscular blockade	63.82	17.12	16	49732	184	90578515
Acute kidney injury	63.62	17.12	345	49403	320042	90258657
Electroencephalogram abnormal	63.34	17.12	35	49713	4061	90574638
Drug reaction with eosinophilia and systemic symptoms	62.75	17.12	96	49652	42662	90536037
Stevens-Johnson syndrome	62.70	17.12	79	49669	29297	90549402
Myoclonic epilepsy	62.55	17.12	26	49722	1601	90577098
Atrioventricular block complete	62.40	17.12	48	49700	9763	90568936
Psoriasis	62.23	17.12	5	49743	147749	90430950
Gene mutation	62.10	17.12	28	49720	2102	90576597
Skin test positive	62.02	17.12	22	49726	878	90577821
Intentional product use issue	61.72	17.12	21	49727	216871	90361828
Chest pain	61.60	17.12	51	49697	319594	90259105
Dry mouth	61.46	17.12	13	49735	184046	90394653
Blister	60.87	17.12	32	49716	254966	90323733
Acute postoperative sialadenitis	60.76	17.12	12	49736	39	90578660
Suspected product quality issue	60.17	17.12	18	49730	414	90578285
Local anaesthetic systemic toxicity	59.94	17.12	32	49716	3468	90575231
Bursitis	59.77	17.12	3	49745	131651	90447048
Musculoskeletal pain	59.47	17.12	11	49737	171240	90407459
Arrhythmia	59.26	17.12	93	49655	42239	90536460
Oxygen saturation abnormal	59.16	17.12	34	49714	4254	90574445
Extravasation	59.07	17.12	30	49718	2934	90575765
Gait inability	58.88	17.12	6	49742	146450	90432249
Product contamination microbial	58.15	17.12	16	49732	270	90578429
Inappropriate schedule of product administration	58.11	17.12	7	49741	149926	90428773
Paralysis	57.83	17.12	49	49699	11429	90567270
Maternal exposure during pregnancy	57.45	17.12	366	49382	359697	90219002
Bronchitis	57.20	17.12	8	49740	152919	90425780
End-tidal CO2 decreased	56.80	17.12	12	49736	59	90578640
Pleocytosis	55.92	17.12	21	49727	987	90577712
Atrioventricular block	55.79	17.12	43	49705	8772	90569927
Upper airway obstruction	55.44	17.12	21	49727	1011	90577688
Hypoaesthesia	54.76	17.12	55	49693	314155	90264544
Asthenia	54.42	17.12	134	49614	533617	90045082
Product use issue	53.87	17.12	61	49687	329858	90248841
Migraine	53.19	17.12	19	49729	190373	90388326
Tachypnoea	53.13	17.12	62	49686	21247	90557452
Depression	53.09	17.12	52	49696	300549	90278150
Wrong product administered	52.06	17.12	39	49709	7626	90571073
Post procedural haemorrhage	51.54	17.12	41	49707	8757	90569942
Inflammation	51.31	17.12	17	49731	178575	90400124
Premature baby	51.25	17.12	66	49682	25011	90553688
Foetal death	51.17	17.12	60	49688	20663	90558036
Injection site pain	50.85	17.12	16	49732	173683	90405016
Pulse absent	50.73	17.12	35	49713	6020	90572679
Acidosis hyperchloraemic	50.72	17.12	19	49729	887	90577812
Brain death	50.50	17.12	30	49718	3991	90574708
Influenza	50.44	17.12	8	49740	139256	90439443
Blood potassium increased	49.46	17.12	59	49689	20690	90558009
Fear	49.39	17.12	53	49695	16569	90562130
Left ventricular dysfunction	49.37	17.12	50	49698	14619	90564080
Blood bicarbonate decreased	49.19	17.12	27	49721	3092	90575607
Hepatic cytolysis	49.06	17.12	72	49676	30844	90547855
Intensive care unit acquired weakness	48.69	17.12	19	49729	992	90577707
Hypocapnia	48.68	17.12	16	49732	505	90578194
Hypovolaemia	48.62	17.12	46	49702	12385	90566314
Sleep disorder	48.52	17.12	24	49724	198006	90380693
General physical health deterioration	48.44	17.12	75	49673	355040	90223659
Respiratory distress	48.31	17.12	81	49667	38865	90539834
Rash maculo-papular	47.96	17.12	83	49665	40850	90537849
Constipation	47.81	17.12	50	49698	280345	90298354
Night sweats	47.54	17.12	7	49741	128759	90449940
Muscle spasms	47.52	17.12	41	49707	251842	90326857
Cyanosis	47.49	17.12	56	49692	19399	90559300
Transcranial electrical motor evoked potential monitoring abnormal	47.46	17.12	9	49739	22	90578677
Muscle relaxant therapy	46.17	17.12	12	49736	161	90578538
Systemic inflammatory response syndrome	46.15	17.12	34	49714	6482	90572217
Cardiovascular insufficiency	46.11	17.12	21	49727	1614	90577085
Eosinophilia	46.07	17.12	67	49681	28466	90550233
Unmasking of previously unidentified disease	44.94	17.12	20	49728	1456	90577243
Loss of personal independence in daily activities	44.64	17.12	10	49738	136095	90442604
Mental status changes postoperative	44.56	17.12	12	49736	186	90578513
Road traffic accident	44.34	17.12	4	49744	107622	90471077
Gastrooesophageal reflux disease	44.13	17.12	18	49730	166319	90412380
Therapeutic product effect prolonged	43.92	17.12	14	49734	400	90578299
Anuria	43.59	17.12	47	49701	14771	90563928
Shock haemorrhagic	43.54	17.12	43	49705	12202	90566497
Sinus bradycardia	43.39	17.12	50	49698	16902	90561797
Atrioventricular block second degree	42.73	17.12	28	49720	4424	90574275
Myocardial ischaemia	42.73	17.12	45	49703	13769	90564930
Face oedema	42.46	17.12	58	49690	23260	90555439
Overdose	42.16	17.12	185	49563	157524	90421175
Hyperlactacidaemia	42.13	17.12	27	49721	4109	90574590
Hyperkalaemia	41.96	17.12	103	49645	64861	90513838
Confusion postoperative	41.74	17.12	12	49736	239	90578460
Pulmonary fibrosis	41.70	17.12	5	49743	107498	90471201
Lactic acidosis	41.46	17.12	88	49660	50375	90528324
Malignant neoplasm progression	41.38	17.12	5	49743	106865	90471834
Memory impairment	41.13	17.12	29	49719	197215	90381484
Pneumonia	40.70	17.12	196	49552	637863	89940836
Hepatorenal failure	40.42	17.12	15	49733	682	90578017
Vocal cord dysfunction	39.90	17.12	16	49732	898	90577801
Supraventricular tachycardia	39.84	17.12	47	49701	16289	90562410
Abdominal pain	39.79	17.12	100	49648	395621	90183078
Hypersensitivity	39.71	17.12	123	49625	454554	90124145
Seizure like phenomena	39.66	17.12	18	49730	1372	90577327
Neuroleptic malignant syndrome	39.44	17.12	45	49703	15051	90563648
Left ventricle outflow tract obstruction	39.29	17.12	13	49735	419	90578280
Negative pressure pulmonary oedema	39.29	17.12	9	49739	68	90578631
Hypoxic-ischaemic encephalopathy	39.15	17.12	27	49721	4641	90574058
Coma scale abnormal	39.05	17.12	29	49719	5597	90573102
Wound infection	38.78	17.12	6	49742	106396	90472303
Back pain	38.63	17.12	72	49676	317103	90261596
Renal injury	38.35	17.12	37	49711	10206	90568493
Procedural hypertension	38.22	17.12	12	49736	326	90578373
Cardiac output decreased	38.20	17.12	16	49732	1004	90577695
Chorea	38.14	17.12	20	49728	2090	90576609
Neck pain	38.13	17.12	8	49740	113955	90464744
Hyperthermia	38.07	17.12	37	49711	10298	90568401
Schizencephaly	38.05	17.12	12	49736	331	90578368
Osteoarthritis	37.97	17.12	31	49717	195699	90383000
Cerebral haemorrhage foetal	37.88	17.12	12	49736	336	90578363
Urinary tract infection	37.56	17.12	69	49679	305563	90273136
Therapeutic product effect decreased	37.48	17.12	59	49689	277512	90301187
Ultrasound ovary abnormal	37.23	17.12	9	49739	88	90578611
Hospitalisation	37.13	17.12	12	49736	128088	90450611
Macroglossia	37.04	17.12	15	49733	864	90577835
Gaze palsy	36.81	17.12	18	49730	1623	90577076
Haematemesis	36.43	17.12	66	49682	33660	90545039
Perforation	36.33	17.12	19	49729	1975	90576724
Osteoporosis	36.21	17.12	5	49743	96526	90482173
Irregular breathing	35.97	17.12	12	49736	397	90578302
Myxoedema coma	35.89	17.12	12	49736	400	90578299
Procedural haemorrhage	35.86	17.12	22	49726	3102	90575597
Procedural nausea	35.86	17.12	16	49732	1172	90577527
Aspartate aminotransferase increased	35.72	17.12	131	49617	102806	90475893
Haemodilution	35.70	17.12	9	49739	106	90578593
Feeling abnormal	35.65	17.12	24	49724	167211	90411488
Bradycardia foetal	35.59	17.12	13	49735	565	90578134
Change in seizure presentation	35.28	17.12	13	49735	579	90578120
Herpes zoster	35.27	17.12	5	49743	94639	90484060
Neutropenia	35.17	17.12	43	49705	224861	90353838
Atrioventricular block first degree	34.25	17.12	32	49716	8479	90570220
Congestive hepatopathy	33.90	17.12	21	49727	3012	90575687
Upper respiratory tract infection	33.85	17.12	14	49734	128304	90450395
Emotional distress	33.73	17.12	67	49681	36595	90542104
Subcutaneous emphysema	33.64	17.12	15	49733	1097	90577602
Cardiotoxicity	33.29	17.12	36	49712	11353	90567346
Pancreatitis necrotising	33.17	17.12	19	49729	2362	90576337
Acute respiratory failure	33.14	17.12	73	49675	42845	90535854
Pulmonary alveolar haemorrhage	33.11	17.12	27	49721	5971	90572728
Oedema peripheral	32.79	17.12	57	49691	257858	90320841
Injection site erythema	32.78	17.12	7	49741	98495	90480204
Patent ductus arteriosus	32.72	17.12	24	49724	4545	90574154
Disease progression	32.68	17.12	23	49725	156592	90422107
Bispectral index decreased	32.54	17.12	5	49743	0	90578699
Adverse event	32.31	17.12	12	49736	117406	90461293
Brain herniation	32.22	17.12	23	49725	4177	90574522
Dry skin	32.02	17.12	5	49743	88068	90490631
Myoglobinuria	32.01	17.12	11	49737	399	90578300
Treatment failure	31.96	17.12	75	49673	303853	90274846
Torticollis	31.90	17.12	19	49729	2539	90576160
Procedural vomiting	31.63	17.12	13	49735	778	90577921
Hypotensive transfusion reaction	31.55	17.12	7	49741	45	90578654
Resuscitation	31.44	17.12	15	49733	1281	90577418
COVID-19	31.21	17.12	28	49720	168815	90409884
Inadequate aseptic technique in use of product	31.15	17.12	7	49741	48	90578651
Circumoral oedema	31.07	17.12	10	49738	295	90578404
Laryngeal stenosis	30.98	17.12	15	49733	1324	90577375
Epilepsy with myoclonic-atonic seizures	30.94	17.12	8	49740	105	90578594
Nystagmus	30.69	17.12	28	49720	7199	90571500
Hepatitis	30.67	17.12	97	49651	70642	90508057
Piloerection	30.62	17.12	12	49736	634	90578065
White blood cell count decreased	30.55	17.12	28	49720	167081	90411618
Therapeutic product effect incomplete	30.39	17.12	37	49711	193859	90384840
Hypercholesterolaemia	30.05	17.12	9	49739	100883	90477816
Peripheral venous disease	29.98	17.12	5	49743	83916	90494783
Apnoeic attack	29.91	17.12	10	49738	333	90578366
Vitamin K deficiency	29.77	17.12	11	49737	494	90578205
Anhedonia	29.74	17.12	34	49714	11397	90567302
Oropharyngeal pain	29.69	17.12	13	49735	115174	90463525
Muscle twitching	29.57	17.12	50	49698	24152	90554547
Blood pressure immeasurable	29.44	17.12	15	49733	1477	90577222
Acute lung injury	29.38	17.12	15	49733	1483	90577216
Atrioventricular dissociation	29.34	17.12	9	49739	226	90578473
Hypertensive crisis	29.06	17.12	42	49706	17742	90560957
Allergy test positive	29.01	17.12	12	49736	730	90577969
Burkholderia test positive	29.00	17.12	9	49739	235	90578464
Oesophageal intramural haematoma	28.69	17.12	8	49740	142	90578557
Foetal exposure during pregnancy	28.67	17.12	69	49679	42906	90535793
Haemoperitoneum	28.64	17.12	20	49728	3508	90575191
Trigemino-cardiac reflex	28.63	17.12	7	49741	72	90578627
Acidosis	28.37	17.12	35	49713	12701	90565998
Periorbital oedema	28.21	17.12	26	49722	6773	90571926
Caesarean section	27.66	17.12	42	49706	18535	90560164
Electrocardiogram repolarisation abnormality	27.63	17.12	14	49734	1362	90577337
Ventricular dysfunction	27.63	17.12	20	49728	3711	90574988
Nasal congestion	27.61	17.12	6	49742	83408	90495291
Post procedural fever	27.43	17.12	10	49738	432	90578267
Procedure aborted	27.43	17.12	8	49740	168	90578531
Bradyarrhythmia	27.41	17.12	17	49731	2444	90576255
Hypovolaemic shock	27.26	17.12	26	49722	7068	90571631
Hypothermia	27.24	17.12	38	49710	15537	90563162
Endotracheal intubation	27.14	17.12	19	49729	3345	90575354
Loss of consciousness	27.10	17.12	150	49598	140088	90438611
Tachyarrhythmia	27.07	17.12	23	49725	5383	90573316
Tongue oedema	26.89	17.12	23	49725	5431	90573268
Pseudocholinesterase deficiency	26.79	17.12	7	49741	96	90578603
Tidal volume decreased	26.72	17.12	6	49742	41	90578658
Myotonia	26.62	17.12	8	49740	187	90578512
Sepsis	26.32	17.12	179	49569	179635	90399064
Anaesthetic complication cardiac	26.23	17.12	6	49742	45	90578654
Coronary artery embolism	26.19	17.12	8	49740	198	90578501
Neuropathy peripheral	26.18	17.12	22	49726	136948	90441751
Administration site extravasation	26.13	17.12	13	49735	1217	90577482
Extrapyramidal disorder	25.91	17.12	38	49710	16265	90562434
Adverse drug reaction	25.89	17.12	16	49732	116685	90462014
Uterine atony	25.87	17.12	9	49739	339	90578360
Lipoedema	25.84	17.12	9	49739	340	90578359
Paradoxical drug reaction	25.79	17.12	23	49725	5743	90572956
Chest discomfort	25.50	17.12	23	49725	138342	90440357
PCO2 decreased	25.45	17.12	13	49735	1287	90577412
Abscess neck	25.40	17.12	11	49737	750	90577949
Chills	25.39	17.12	141	49607	131840	90446859
Lung disorder	25.22	17.12	27	49721	149856	90428843
Prescribed overdose	25.19	17.12	11	49737	97614	90481085
Somatosensory evoked potentials abnormal	25.14	17.12	5	49743	17	90578682
Ventricular arrhythmia	25.02	17.12	20	49728	4301	90574398
Illness	24.99	17.12	7	49741	81962	90496737
Intensive care unit delirium	24.88	17.12	6	49742	58	90578641
Disinhibition	24.82	17.12	12	49736	1056	90577643
Death	24.77	17.12	148	49600	456403	90122296
Respiratory rate decreased	24.27	17.12	19	49729	3964	90574735
Extrasystoles	24.18	17.12	22	49726	5635	90573064
Brachial plexopathy	24.12	17.12	8	49740	260	90578439
Cholestasis	23.91	17.12	58	49690	36241	90542458
Encephalitis	23.85	17.12	30	49718	11104	90567595
Hypertrophic cardiomyopathy	23.83	17.12	15	49733	2213	90576486
Ischaemic cerebral infarction	23.65	17.12	13	49735	1493	90577206
CSWS syndrome	23.60	17.12	5	49743	25	90578674
Hyperammonaemic encephalopathy	23.56	17.12	16	49732	2683	90576016
Taste disorder	23.53	17.12	3	49745	61543	90517156
Apgar score low	23.46	17.12	12	49736	1191	90577508
Extubation	23.43	17.12	5	49743	26	90578673
Hyperdynamic left ventricle	23.39	17.12	8	49740	286	90578413
Thyrotoxic crisis	23.20	17.12	12	49736	1219	90577480
C-reactive protein increased	23.13	17.12	40	49708	181349	90397350
Fanconi syndrome	23.11	17.12	14	49734	1929	90576770
Eyelid function disorder	23.05	17.12	8	49740	299	90578400
Polyuria	23.03	17.12	28	49720	10012	90568687
Euthyroid sick syndrome	22.98	17.12	6	49742	82	90578617
Hypernatraemia	22.88	17.12	27	49721	9360	90569339
Accidental overdose	22.87	17.12	49	49699	28224	90550475
Sepsis syndrome	22.81	17.12	11	49737	962	90577737
Haemodialysis	22.73	17.12	26	49722	8721	90569978
Infantile apnoea	22.70	17.12	12	49736	1275	90577424
Congenital clavicular agenesis	22.46	17.12	6	49742	90	90578609
Hepatitis C	22.24	17.12	21	49727	5639	90573060
Abdominal rigidity	22.18	17.12	15	49733	2497	90576202
Mixed liver injury	22.11	17.12	24	49724	7599	90571100
Bronchostenosis	21.97	17.12	9	49739	534	90578165
Normal newborn	21.86	17.12	43	49705	23319	90555380
Skin test negative	21.80	17.12	5	49743	38	90578661
Blood triglycerides increased	21.76	17.12	32	49716	13729	90564970
Haematochezia	21.72	17.12	6	49742	70907	90507792
End-tidal CO2 increased	21.64	17.12	4	49744	8	90578691
Supraventricular extrasystoles	21.61	17.12	20	49728	5237	90573462
Mean arterial pressure decreased	21.60	17.12	7	49741	211	90578488
Ventricular asystole	21.60	17.12	6	49742	105	90578594
Air embolism	21.53	17.12	8	49740	365	90578334
Acquired macroglossia	21.42	17.12	7	49741	217	90578482
Areflexia	21.34	17.12	17	49731	3636	90575063
Monoplegia	21.26	17.12	17	49731	3657	90575042
Chronic obstructive pulmonary disease	21.25	17.12	7	49741	73822	90504877
Fluid retention	21.08	17.12	11	49737	88080	90490619
Bezold-Jarisch reflex	21.05	17.12	5	49743	45	90578654
Visual impairment	21.01	17.12	25	49723	132340	90446359
Cardiovascular disorder	20.79	17.12	31	49717	13461	90565238
Cardiac failure acute	20.71	17.12	29	49719	11900	90566799
Ammonia increased	20.55	17.12	19	49729	4967	90573732
Hepatic function abnormal	20.55	17.12	64	49684	46224	90532475
Dehydration	20.41	17.12	48	49700	194399	90384300
Cough	20.32	17.12	119	49629	368843	90209856
Cardiac massage	20.25	17.12	4	49744	13	90578686
Paraplegia	20.20	17.12	16	49732	3396	90575303
Brain injury	20.10	17.12	23	49725	7715	90570984
Injection site reaction	19.91	17.12	13	49735	92067	90486632
Long QT syndrome	19.86	17.12	17	49731	4020	90574679
Idiosyncratic drug reaction	19.85	17.12	10	49738	961	90577738
Anaemia	19.85	17.12	113	49635	352689	90226010
Neurological decompensation	19.83	17.12	16	49732	3485	90575214
Brain stem syndrome	19.48	17.12	9	49739	715	90577984
Bone pain	19.44	17.12	5	49743	61978	90516721
Tonic clonic movements	19.44	17.12	12	49736	1710	90576989
Urine amphetamine positive	19.38	17.12	5	49743	65	90578634
Dermatitis bullous	19.30	17.12	26	49722	10290	90568409
Grimacing	19.27	17.12	8	49740	491	90578208
Agitation postoperative	19.22	17.12	4	49744	18	90578681
Confusional arousal	19.21	17.12	7	49741	302	90578397
Condition aggravated	19.11	17.12	222	49526	595323	89983376
Conjunctival hyperaemia	19.06	17.12	15	49733	3154	90575545
Renal tubular necrosis	19.03	17.12	31	49717	14524	90564175
Tracheal injury	18.97	17.12	6	49742	167	90578532
Paraesthesia	18.92	17.12	72	49676	250254	90328445
Paresis	18.86	17.12	14	49734	2700	90575999
Extensor plantar response	18.85	17.12	11	49737	1416	90577283
Eye movement disorder	18.83	17.12	20	49728	6178	90572521
Chromaturia	18.79	17.12	36	49712	19151	90559548
Lymphangiectasia	18.78	17.12	5	49743	74	90578625
Echolalia	18.70	17.12	7	49741	326	90578373
Salivary hypersecretion	18.69	17.12	24	49724	9068	90569631
Abdominal sepsis	18.62	17.12	11	49737	1448	90577251
Heart rate decreased	18.47	17.12	68	49680	53437	90525262
Suspected product contamination	18.42	17.12	5	49743	80	90578619
Systolic dysfunction	18.34	17.12	12	49736	1892	90576807
Coronary artery bypass	18.33	17.12	13	49735	2336	90576363
Oedema	18.31	17.12	53	49695	200242	90378457
Tachyphylaxis	18.30	17.12	7	49741	346	90578353
Haemorrhage	18.24	17.12	81	49667	69288	90509411
Postoperative respiratory failure	18.12	17.12	4	49744	25	90578674
Cystitis	18.05	17.12	7	49741	66711	90511988
Clonic convulsion	18.00	17.12	9	49739	851	90577848
Low birth weight baby	17.92	17.12	24	49724	9443	90569256
Spinal cord disorder	17.91	17.12	11	49737	1554	90577145
Laryngeal obstruction	17.87	17.12	5	49743	90	90578609
Lip oedema	17.82	17.12	17	49731	4622	90574077
Delirium	17.79	17.12	108	49640	104251	90474448
Underdose	17.65	17.12	4	49744	54013	90524686
Foetal heart rate decreased	17.61	17.12	6	49742	212	90578487
Rhythm idioventricular	17.47	17.12	7	49741	392	90578307
Nerve stimulation test abnormal	17.45	17.12	3	49745	3	90578696
Capnogram abnormal	17.45	17.12	3	49745	3	90578696
Head circumference abnormal	17.45	17.12	3	49745	3	90578696
Peripheral nerve palsy	17.37	17.12	4	49744	31	90578668
Dyspnoea exertional	17.34	17.12	9	49739	72279	90506420
Vision blurred	17.32	17.12	21	49727	110272	90468427
Blood magnesium decreased	17.32	17.12	31	49717	15662	90563037
Eyelid contusion	17.23	17.12	5	49743	103	90578596
Pseudomonas infection	17.22	17.12	30	49718	14835	90563864
Left ventricular hypertrophy	17.22	17.12	19	49729	6125	90572574
Atelectasis	17.16	17.12	40	49708	24369	90554330
Syncope	17.14	17.12	29	49719	132634	90446065
Tracheal haemorrhage	17.12	17.12	6	49742	231	90578468

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Anaphylactic shock	2650.01	15.82	994	46796	22523	42551022
Propofol infusion syndrome	1568.65	15.82	345	47445	864	42572681
Anaphylactic reaction	1159.81	15.82	674	47116	42069	42531476
Hyperthermia malignant	803.67	15.82	237	47553	2421	42571124
Cardiac arrest	777.54	15.82	773	47017	108547	42464998
Hypotension	766.49	15.82	1172	46618	256459	42317086
Bronchospasm	571.13	15.82	282	47508	12603	42560942
Bradycardia	523.05	15.82	558	47232	84926	42488619
Rhabdomyolysis	507.09	15.82	526	47264	77493	42496052
Delayed recovery from anaesthesia	428.01	15.82	121	47669	1048	42572497
Serotonin syndrome	340.01	15.82	260	47530	25585	42547960
Tachycardia	316.02	15.82	472	47318	100615	42472930
Fatigue	306.70	15.82	59	47731	435582	42137963
Anaesthetic complication neurological	273.15	15.82	77	47713	659	42572886
Circulatory collapse	257.77	15.82	213	47577	23423	42550122
Metabolic acidosis	221.93	15.82	282	47508	51576	42521969
Diarrhoea	220.27	15.82	122	47668	460727	42112818
Anaesthetic complication	209.87	15.82	74	47716	1383	42572162
Haemodynamic instability	209.74	15.82	146	47644	12411	42561134
Neuromuscular block prolonged	199.42	15.82	58	47732	561	42572984
Pulseless electrical activity	196.98	15.82	121	47669	8316	42565229
Respiratory depression	193.23	15.82	164	47626	18704	42554841
Hypoxia	188.72	15.82	305	47485	69481	42504064
Electrocardiogram ST segment elevation	188.59	15.82	104	47686	5835	42567710
Status epilepticus	181.64	15.82	146	47644	15432	42558113
Shock	181.06	15.82	192	47598	28929	42544616
Diabetes insipidus	175.62	15.82	85	47705	3628	42569917
Oxygen saturation decreased	167.15	15.82	277	47513	64410	42509135
Death	160.17	15.82	176	47614	471009	42102536
Arthralgia	156.94	15.82	22	47768	205216	42368329
Drug interaction	153.04	15.82	648	47142	266351	42307194
Drug reaction with eosinophilia and systemic symptoms	152.53	15.82	211	47579	41864	42531681
Negative pressure pulmonary oedema	151.39	15.82	47	47743	578	42572967
Myoclonus	148.04	15.82	135	47655	16930	42556615
Hypertriglyceridaemia	146.73	15.82	108	47682	10018	42563527
Laryngospasm	136.54	15.82	59	47731	1929	42571616
Decreased appetite	135.83	15.82	26	47764	193111	42380434
Product dose omission issue	134.85	15.82	10	47780	154355	42419190
Trigemino-cardiac reflex	133.99	15.82	38	47752	333	42573212
Blood pressure decreased	129.99	15.82	234	47556	58098	42515447
Ventricular fibrillation	129.09	15.82	164	47626	29959	42543586
Dizziness	124.62	15.82	62	47728	249192	42324353
Airway complication of anaesthesia	122.50	15.82	31	47759	166	42573379
Fall	122.36	15.82	55	47735	234465	42339080
Procedural hypotension	122.16	15.82	45	47745	958	42572587
Intensive care unit acquired weakness	122.01	15.82	48	47742	1230	42572315
Respiratory acidosis	120.92	15.82	80	47710	6251	42567294
Arteriospasm coronary	118.43	15.82	71	47719	4667	42568878
Blood creatine phosphokinase increased	114.24	15.82	199	47591	48139	42525406
Procedural complication	112.72	15.82	66	47724	4153	42569392
Cardio-respiratory arrest	109.30	15.82	218	47572	58418	42515127
Hypoxic-ischaemic encephalopathy	107.35	15.82	69	47721	5133	42568412
Respiratory arrest	106.69	15.82	145	47645	28279	42545266
Nausea	106.46	15.82	176	47614	396623	42176922
Headache	106.09	15.82	69	47721	239300	42334245
Ventricular tachycardia	105.92	15.82	149	47641	30011	42543534
Injury	104.43	15.82	127	47663	22189	42551356
Asthenia	104.14	15.82	97	47693	280696	42292849
Pain in extremity	100.24	15.82	23	47767	150581	42422964
Apnoea	99.26	15.82	77	47713	7726	42565819
Toxic epidermal necrolysis	98.19	15.82	135	47655	26615	42546930
Agitation	97.73	15.82	220	47570	64094	42509451
Stress cardiomyopathy	97.40	15.82	52	47738	2733	42570812
Postoperative delirium	96.15	15.82	33	47757	567	42572978
Febrile neutropenia	96.11	15.82	44	47746	185659	42387886
Tachypnoea	96.08	15.82	120	47670	21542	42552003
Multiple organ dysfunction syndrome	94.73	15.82	281	47509	96754	42476791
Weight decreased	92.04	15.82	60	47730	207888	42365657
Airway peak pressure increased	91.97	15.82	24	47766	148	42573397
Acute respiratory distress syndrome	91.59	15.82	139	47651	29969	42543576
Anaphylactoid shock	91.35	15.82	30	47760	447	42573098
Drug ineffective	89.31	15.82	1087	46703	629110	41944435
Abdominal pain	88.38	15.82	52	47738	190419	42383126
Dyspnoea	87.09	15.82	234	47556	442387	42131158
Seizure like phenomena	86.80	15.82	36	47754	1061	42572484
Sinus arrest	86.10	15.82	44	47746	2112	42571433
Non-cardiogenic pulmonary oedema	85.35	15.82	34	47756	901	42572644
Constipation	84.67	15.82	38	47752	162253	42411292
Pulse absent	83.90	15.82	64	47726	6263	42567282
Mechanical ventilation complication	83.59	15.82	31	47759	673	42572872
Vasoplegia syndrome	82.93	15.82	46	47744	2609	42570936
Neuropathy peripheral	82.45	15.82	9	47781	101844	42471701
Multiple-drug resistance	81.90	15.82	67	47723	7255	42566290
Hypercapnia	81.79	15.82	59	47731	5302	42568243
Post procedural complication	81.77	15.82	85	47705	12505	42561040
Hypoventilation	79.86	15.82	51	47739	3751	42569794
Disease progression	79.17	15.82	31	47759	143625	42429920
Intestinal ischaemia	78.94	15.82	73	47717	9315	42564230
Malaise	78.93	15.82	73	47717	212083	42361462
Peripheral swelling	78.36	15.82	6	47784	90264	42483281
Kounis syndrome	77.83	15.82	48	47742	3320	42570225
Nasopharyngitis	77.63	15.82	4	47786	83992	42489553
Malignant neoplasm progression	77.41	15.82	14	47776	108386	42465159
Autonomic nervous system imbalance	76.08	15.82	46	47744	3070	42570475
Brugada syndrome	74.78	15.82	32	47758	1021	42572524
Weight increased	72.81	15.82	16	47774	107967	42465578
Urticaria	72.80	15.82	215	47575	73821	42499724
Type I hypersensitivity	71.72	15.82	39	47751	2127	42571418
Erythema	71.59	15.82	276	47514	108517	42465028
Brain injury	71.19	15.82	63	47727	7592	42565953
Spinal muscular atrophy	71.05	15.82	24	47766	392	42573153
Respiratory failure	70.83	15.82	308	47482	127824	42445721
Hospitalisation	70.44	15.82	3	47787	74327	42499218
Fear	69.37	15.82	73	47717	10892	42562653
Anaemia	68.11	15.82	132	47658	280146	42293399
Ventricular arrhythmia	67.19	15.82	56	47734	6223	42567322
Inappropriate schedule of product administration	67.16	15.82	13	47777	95889	42477656
Transmission of an infectious agent via product	66.54	15.82	19	47771	171	42573374
Cyanosis	66.22	15.82	83	47707	14948	42558597
Drug ineffective for unapproved indication	65.78	15.82	154	47636	46009	42527536
Priapism	64.16	15.82	55	47735	6352	42567193
Muscle rigidity	63.65	15.82	73	47717	11986	42561559
Oedema peripheral	63.30	15.82	37	47753	136039	42437506
Torsade de pointes	63.09	15.82	62	47728	8532	42565013
Cough	60.82	15.82	66	47724	178037	42395508
Resuscitation	60.81	15.82	33	47757	1792	42571753
Product contamination microbial	60.65	15.82	25	47765	725	42572820
Dyskinesia	60.57	15.82	105	47685	25285	42548260
White blood cell count decreased	60.52	15.82	24	47766	110372	42463173
Brain oedema	57.81	15.82	81	47709	16246	42557299
Renal injury	57.63	15.82	70	47720	12210	42561335
Feeling abnormal	56.90	15.82	6	47784	69780	42503765
Electrocardiogram QRS complex prolonged	56.31	15.82	49	47741	5774	42567771
Endotracheal intubation	56.25	15.82	41	47749	3744	42569801
Drug level changed	56.21	15.82	20	47770	384	42573161
Acidosis	56.01	15.82	69	47721	12210	42561335
Blood lactic acid increased	55.33	15.82	56	47734	7983	42565562
Recurrence of neuromuscular blockade	55.32	15.82	18	47772	260	42573285
Neuromuscular blockade	55.06	15.82	19	47771	332	42573213
Neutropenia	54.68	15.82	87	47703	199344	42374201
Sinus bradycardia	54.55	15.82	75	47715	14778	42558767
Pneumonia	54.49	15.82	266	47524	421883	42151662
Anhedonia	54.01	15.82	54	47736	7586	42565959
Insomnia	53.80	15.82	33	47757	118220	42455325
Drug withdrawal syndrome	52.56	15.82	90	47700	21459	42552086
Tryptase increased	52.30	15.82	18	47772	312	42573233
Rash maculo-papular	52.22	15.82	124	47666	37379	42536166
Post procedural fever	51.97	15.82	16	47774	191	42573354
Allergy test negative	50.94	15.82	15	47775	152	42573393
Neonatal respiratory depression	49.80	15.82	19	47771	447	42573098
Necrosis ischaemic	49.31	15.82	18	47772	373	42573172
Hyperthermia	48.47	15.82	65	47725	12509	42561036
Nephrogenic diabetes insipidus	48.42	15.82	27	47763	1547	42571998
Endotracheal intubation complication	48.35	15.82	18	47772	395	42573150
Hyperkalaemia	47.98	15.82	198	47592	80260	42493285
Generalised tonic-clonic seizure	47.83	15.82	97	47693	26282	42547263
Opisthotonus	47.45	15.82	20	47770	614	42572931
Unwanted awareness during anaesthesia	46.91	15.82	11	47779	40	42573505
Urinary tract infection	46.15	15.82	27	47763	99257	42474288
Dystonia	46.10	15.82	64	47726	12726	42560819
Increased bronchial secretion	45.66	15.82	30	47760	2316	42571229
Pancytopenia	45.56	15.82	39	47751	117704	42455841
Paraesthesia	45.42	15.82	13	47777	73446	42500099
Pneumococcal sepsis	44.87	15.82	25	47765	1430	42572115
Hepatorenal failure	44.17	15.82	19	47771	614	42572931
Chest pain	44.06	15.82	55	47735	139475	42434070
Anaphylactoid reaction	43.62	15.82	32	47758	2951	42570594
Dehydration	43.61	15.82	57	47733	141710	42431835
Motor neurone disease	43.07	15.82	18	47772	541	42573004
Procedural haemorrhage	42.73	15.82	31	47759	2810	42570735
Hypothermia	42.69	15.82	61	47729	12454	42561091
Atrioventricular block complete	42.66	15.82	58	47732	11306	42562239
Partial seizures	42.50	15.82	42	47748	5817	42567728
Pruritus	42.33	15.82	93	47697	188678	42384867
Post procedural hypotension	42.13	15.82	11	47779	68	42573477
Oxygen saturation immeasurable	42.10	15.82	10	47780	39	42573506
Mixed liver injury	41.96	15.82	37	47753	4437	42569108
Stoma closure	41.92	15.82	15	47775	293	42573252
COVID-19	41.78	15.82	41	47749	115907	42457638
Product contamination	41.76	15.82	21	47769	974	42572571
Cellulitis	41.75	15.82	9	47781	61576	42511969
General physical health deterioration	41.42	15.82	66	47724	151180	42422365
Shock haemorrhagic	41.15	15.82	69	47721	16173	42557372
Anaesthetic complication cardiac	40.48	15.82	9	47781	24	42573521
Diabetes mellitus	40.29	15.82	9	47781	60078	42513467
Emotional distress	40.28	15.82	68	47722	16025	42557520
Neuroleptic malignant syndrome	40.17	15.82	80	47710	21392	42552153
Vomiting	40.00	15.82	178	47612	289545	42284000
Dry skin	39.80	15.82	4	47786	48334	42525211
Clonus	38.93	15.82	32	47758	3488	42570057
Loss of personal independence in daily activities	38.82	15.82	5	47785	49811	42523734
Cardiac failure congestive	38.77	15.82	24	47766	85578	42487967
Back pain	38.69	15.82	62	47728	141714	42431831
Pain	38.45	15.82	143	47647	244705	42328840
Influenza	38.44	15.82	11	47779	62164	42511381
Depression	38.28	15.82	41	47749	111322	42462223
Hypotonia	37.99	15.82	50	47740	9449	42564096
Haemodialysis	37.97	15.82	52	47738	10208	42563337
Anti factor V antibody	37.87	15.82	14	47776	301	42573244
Burkholderia test positive	37.83	15.82	20	47770	1030	42572515
Therapeutic product effect prolonged	37.74	15.82	14	47776	304	42573241
Sedation complication	37.55	15.82	29	47761	2890	42570655
Coma blister	37.48	15.82	10	47780	68	42573477
Coagulopathy	37.25	15.82	79	47711	22083	42551462
Electroencephalogram abnormal	36.91	15.82	29	47761	2963	42570582
Pseudocholinesterase deficiency	36.40	15.82	10	47780	77	42573468
Lower respiratory tract infection bacterial	36.33	15.82	16	47774	548	42572997
Pneumothorax	36.24	15.82	81	47709	23462	42550083
Hypotonic-hyporesponsive episode	36.08	15.82	8	47782	21	42573524
Mucosal inflammation	36.05	15.82	6	47784	49368	42524177
Neutrophil count decreased	36.05	15.82	13	47777	63402	42510143
Electrocardiogram QT prolonged	35.99	15.82	127	47663	47818	42525727
Blood pressure measurement	35.98	15.82	12	47778	188	42573357
Unresponsive to stimuli	35.54	15.82	96	47694	31307	42542238
Symmetrical drug-related intertriginous and flexural exanthema	35.49	15.82	18	47772	850	42572695
Chromaturia	35.39	15.82	64	47726	15925	42557620
Acute pulmonary oedema	35.31	15.82	46	47744	8605	42564940
Dyspepsia	35.17	15.82	3	47787	41349	42532196
Sinus tachycardia	35.15	15.82	74	47716	20579	42552966
Abdominal pain upper	34.93	15.82	25	47765	82584	42490961
Mechanical ventilation	34.60	15.82	25	47765	2252	42571293
Ischaemic cerebral infarction	34.41	15.82	22	47768	1621	42571924
Balance disorder	34.33	15.82	6	47784	47639	42525906
Delirium	34.30	15.82	133	47657	52386	42521159
Plasma cell myeloma	34.26	15.82	6	47784	47572	42525973
Metabolic disorder	34.13	15.82	34	47756	4754	42568791
Chronic obstructive pulmonary disease	34.12	15.82	14	47776	63100	42510445
Hyperammonaemia	33.95	15.82	43	47747	7823	42565722
Respiratory tract infection bacterial	33.76	15.82	23	47767	1886	42571659
Sputum increased	33.41	15.82	28	47762	3135	42570410
Haemothorax	33.37	15.82	35	47755	5201	42568344
Heparin-induced thrombocytopenia	33.24	15.82	39	47751	6558	42566987
Lactic acidosis	33.21	15.82	119	47671	45142	42528403
Superinfection	32.99	15.82	27	47763	2924	42570621
Stomatitis	32.83	15.82	8	47782	50321	42523224
Eosinophilia	32.74	15.82	96	47694	32803	42540742
Suicidal ideation	32.72	15.82	7	47783	48154	42525391
Intestinal pseudo-obstruction	32.54	15.82	24	47766	2231	42571314
Pancreatitis acute	32.51	15.82	97	47693	33467	42540078
Nodal rhythm	32.26	15.82	21	47769	1596	42571949
Disease complication	32.06	15.82	27	47763	3043	42570502
Drug intolerance	31.89	15.82	26	47764	80398	42493147
Lymphadenectomy	31.56	15.82	14	47776	488	42573057
Muscle spasms	31.48	15.82	30	47760	86014	42487531
Prostate cancer	31.35	15.82	6	47784	44637	42528908
Hepatitis fulminant	31.34	15.82	33	47757	4926	42568619
Dry mouth	31.08	15.82	4	47786	39875	42533670
Locked-in syndrome	31.00	15.82	13	47777	394	42573151
Contusion	30.88	15.82	5	47785	41980	42531565
Pulmonary oedema	30.88	15.82	130	47660	53142	42520403
Dyspnoea exertional	30.76	15.82	9	47781	50139	42523406
Hyporesponsive to stimuli	30.65	15.82	20	47770	1526	42572019
Methaemoglobinaemia	30.55	15.82	35	47755	5739	42567806
Mean arterial pressure decreased	30.40	15.82	11	47779	222	42573323
Overdose	30.28	15.82	212	47578	105052	42468493
Confusion postoperative	30.15	15.82	10	47780	154	42573391
Bronchial disorder	29.97	15.82	19	47771	1379	42572166
Pulmonary alveolar haemorrhage	29.90	15.82	57	47733	14759	42558786
Suspected product quality issue	29.65	15.82	11	47779	239	42573306
End-tidal CO2 increased	29.13	15.82	7	47783	29	42573516
Electrocardiogram ST-T segment elevation	28.97	15.82	5	47785	0	42573545
Coronary artery disease	28.90	15.82	12	47778	53708	42519837
Asthma	28.87	15.82	17	47773	62297	42511248
Abdominal compartment syndrome	28.76	15.82	17	47773	1088	42572457
Oculocardiac reflex	28.60	15.82	9	47781	116	42573429
Gait disturbance	28.51	15.82	41	47749	97959	42475586
Pulmonary embolism	28.41	15.82	57	47733	119555	42453990
Pigment nephropathy	28.40	15.82	7	47783	33	42573512
Haemoglobin decreased	28.27	15.82	67	47723	132404	42441141
Disseminated intravascular coagulation	28.26	15.82	76	47714	24718	42548827
Upper airway obstruction	28.26	15.82	15	47775	779	42572766
Face oedema	28.11	15.82	53	47737	13613	42559932
Sinusitis	28.09	15.82	9	47781	47283	42526262
Mucosal ulceration	28.03	15.82	18	47772	1336	42572209
Bronchitis	28	15.82	9	47781	47192	42526353
Supraventricular tachycardia	27.89	15.82	50	47740	12358	42561187
Herpes zoster	27.78	15.82	5	47785	38872	42534673
Anticholinergic syndrome	27.76	15.82	19	47771	1570	42571975
Areflexia	27.46	15.82	27	47763	3716	42569829
Hyponatraemia	27.08	15.82	45	47745	101417	42472128
PCO2 increased	27.03	15.82	14	47776	691	42572854
Cerebral ischaemia	26.86	15.82	36	47754	6923	42566622
Inspiratory capacity decreased	26.76	15.82	24	47766	2943	42570602
Ventricular extrasystoles	26.39	15.82	51	47739	13339	42560206
Angina pectoris	26.37	15.82	3	47787	32893	42540652
Brain death	26.30	15.82	24	47766	3010	42570535
Thrombosis	26.11	15.82	23	47767	68488	42505057
Intracranial pressure increased	25.86	15.82	29	47761	4645	42568900
Atelectasis	25.85	15.82	63	47727	19298	42554247
Platelet count decreased	25.82	15.82	75	47715	138506	42435039
Acute kidney injury	25.72	15.82	565	47225	366772	42206773
Syncope	25.69	15.82	45	47745	99361	42474184
Sodium retention	25.65	15.82	8	47782	100	42573445
Prinzmetal angina	25.55	15.82	17	47773	1340	42572205
Post procedural haemorrhage	25.53	15.82	41	47749	9271	42564274
Trismus	25.36	15.82	23	47767	2861	42570684
Electrocardiogram T wave inversion	25.35	15.82	21	47769	2313	42571232
Administration related reaction	25.33	15.82	9	47781	172	42573373
Myoglobinuria	25.32	15.82	14	47776	789	42572756
Myelosuppression	25.30	15.82	7	47783	40454	42533091
Systemic inflammatory response syndrome	25.18	15.82	36	47754	7354	42566191
Chest X-ray abnormal	24.99	15.82	28	47762	4480	42569065
Infusion related reaction	24.93	15.82	19	47771	60787	42512758
Hypoaesthesia	24.90	15.82	26	47764	71437	42502108
Paroxysmal sympathetic hyperactivity	24.72	15.82	7	47783	61	42573484
Depressed level of consciousness	24.71	15.82	113	47677	47857	42525688
Premature recovery from anaesthesia	24.60	15.82	5	47785	7	42573538
Musculoskeletal pain	24.46	15.82	4	47786	33336	42540209
Ventricular asystole	24.26	15.82	10	47780	290	42573255
Subcutaneous emphysema	24.24	15.82	18	47772	1691	42571854
Ileus	24.20	15.82	61	47729	19078	42554467
Laryngeal oedema	24.14	15.82	26	47764	3982	42569563
Myoglobinaemia	24.11	15.82	9	47781	199	42573346
Suspected product contamination	24.11	15.82	9	47781	199	42573346
Swelling	24.01	15.82	16	47774	54869	42518676
Sleep disorder	23.91	15.82	12	47778	48083	42525462
Scoliosis	23.78	15.82	23	47767	3103	42570442
Chest discomfort	23.48	15.82	22	47768	63594	42509951
Rash morbilliform	23.38	15.82	26	47764	4127	42569418
Palpitations	23.33	15.82	14	47776	50783	42522762
Hypernatraemia	23.28	15.82	41	47749	9991	42563554
Skin test positive	23.15	15.82	11	47779	450	42573095
Haematuria traumatic	22.91	15.82	10	47780	335	42573210
Nasal congestion	22.89	15.82	3	47787	29498	42544047
Air embolism	22.54	15.82	9	47781	240	42573305
Electrocardiogram ST segment depression	22.46	15.82	21	47769	2716	42570829
Pupil fixed	22.41	15.82	18	47772	1899	42571646
Seizure	22.40	15.82	220	47570	120341	42453204
Neoplasm progression	22.38	15.82	3	47787	28997	42544548
Capillary nail refill test abnormal	22.34	15.82	6	47784	42	42573503
Systolic anterior motion of mitral valve	22.34	15.82	6	47784	42	42573503
Unmasking of previously unidentified disease	22.19	15.82	15	47775	1214	42572331
Infection	22.10	15.82	59	47731	112009	42461536
Spinal cord infarction	22.07	15.82	12	47778	654	42572891
Atrioventricular block	21.94	15.82	39	47751	9576	42563969
Haematochezia	21.81	15.82	20	47770	58416	42515129
Coma	21.80	15.82	118	47672	53436	42520109
Urinary bladder rupture	21.78	15.82	7	47783	97	42573448
Cardiac output decreased	21.66	15.82	14	47776	1051	42572494
Oliguria	21.54	15.82	38	47752	9275	42564270
Productive cough	21.28	15.82	16	47774	51551	42521994
Dysgeusia	21.22	15.82	6	47784	34183	42539362
Motor dysfunction	21.16	15.82	35	47755	8111	42565434
Neonatal hypoxia	21.13	15.82	11	47779	549	42572996
Nystagmus	20.95	15.82	28	47762	5368	42568177
Klebsiella infection	20.93	15.82	42	47748	11290	42562255
Rhinorrhoea	20.84	15.82	5	47785	31789	42541756
Adverse reaction	20.78	15.82	24	47766	3969	42569576
Myoglobin blood increased	20.64	15.82	23	47767	3659	42569886
Continuous haemodiafiltration	20.54	15.82	13	47777	941	42572604
Mobility decreased	20.47	15.82	7	47783	35299	42538246
Renin increased	20.44	15.82	8	47782	202	42573343
Respiratory distress	20.43	15.82	97	47693	41723	42531822
Acute respiratory failure	20.36	15.82	92	47698	38766	42534779
Chronic kidney disease	20.36	15.82	14	47776	47227	42526318
Post-injection delirium sedation syndrome	20.27	15.82	11	47779	597	42572948
Upper respiratory tract infection	20.26	15.82	11	47779	42162	42531383
Renal failure	20.14	15.82	248	47542	143478	42430067
Unevaluable event	20.12	15.82	84	47706	34204	42539341
Blood cholesterol increased	20.09	15.82	3	47787	26738	42546807
Fear of death	20.04	15.82	11	47779	611	42572934
Respiratory tract infection	19.66	15.82	3	47787	26319	42547226
Local anaesthetic systemic toxicity	19.56	15.82	18	47772	2282	42571263
Colitis ulcerative	19.52	15.82	3	47787	26172	42547373
Blood catecholamines increased	19.42	15.82	5	47785	29	42573516
Mydriasis	19.27	15.82	35	47755	8735	42564810
Gout	19.22	15.82	4	47786	28051	42545494
Acidosis hyperchloraemic	19.12	15.82	11	47779	669	42572876
Congenital megaureter	19.09	15.82	7	47783	147	42573398
Bradyarrhythmia	19.08	15.82	19	47771	2656	42570889
Septic shock	18.87	15.82	171	47619	91501	42482044
Nephrolithiasis	18.60	15.82	9	47781	36821	42536724
Gastrointestinal disorder	18.59	15.82	15	47775	46638	42526907
Acute generalised exanthematous pustulosis	18.51	15.82	34	47756	8561	42564984
Neuromyopathy	18.50	15.82	13	47777	1121	42572424
Hyperbilirubinaemia	18.45	15.82	58	47732	20577	42552968
Leukocytosis	18.39	15.82	74	47716	29634	42543911
Pneumomediastinum	18.39	15.82	20	47770	3096	42570449
Blood triglycerides increased	18.39	15.82	49	47741	15847	42557698
Intestinal obstruction	18.34	15.82	4	47786	27154	42546391
Conversion disorder	18.31	15.82	10	47780	550	42572995
Myopathy toxic	18.25	15.82	11	47779	730	42572815
Eye movement disorder	18.20	15.82	25	47765	4920	42568625
Dialysis	18.18	15.82	41	47749	11945	42561600
Euthanasia	18.14	15.82	5	47785	39	42573506
Subdural effusion	18.05	15.82	6	47784	93	42573452
Hypocapnia	18.04	15.82	9	47781	410	42573135
Hepatocellular injury	18.00	15.82	63	47727	23615	42549930
Muscle contracture	17.90	15.82	14	47776	1421	42572124
Blood pressure immeasurable	17.81	15.82	12	47778	966	42572579
Transcranial electrical motor evoked potential monitoring abnormal	17.65	15.82	4	47786	12	42573533
Skin test negative	17.61	15.82	5	47785	44	42573501
Withdrawal syndrome	17.55	15.82	46	47744	14729	42558816
Product administered to patient of inappropriate age	17.42	15.82	24	47766	4737	42568808
Therapeutic response prolonged	17.38	15.82	3	47787	0	42573545
Light anaesthesia	17.38	15.82	3	47787	0	42573545
Biliary cast syndrome	17.38	15.82	3	47787	0	42573545
Rectal haemorrhage	17.33	15.82	18	47772	49588	42523957
Neck pain	17.32	15.82	6	47784	30008	42543537
Gastrooesophageal reflux disease	17.29	15.82	15	47775	45008	42528537
Malignant catatonia	17.27	15.82	9	47781	450	42573095
Bone pain	17.13	15.82	3	47787	23789	42549756
Hypovolaemia	17.10	15.82	39	47751	11446	42562099
Thyrotoxic crisis	17.05	15.82	11	47779	823	42572722
Skin exfoliation	17.01	15.82	13	47777	41540	42532005
Visual impairment	17.00	15.82	14	47776	43099	42530446
Adverse event	16.98	15.82	3	47787	23637	42549908
Angioedema	16.88	15.82	93	47697	42384	42531161
Electrocardiogram abnormal	16.86	15.82	36	47754	10109	42563436
Postoperative respiratory distress	16.76	15.82	4	47786	16	42573529
Blood glucose increased	16.75	15.82	36	47754	73663	42499882
Hepatic cytolysis	16.73	15.82	67	47723	26777	42546768
Chills	16.67	15.82	170	47620	93896	42479649
Dysuria	16.64	15.82	7	47783	31089	42542456
Incorrect drug administration rate	16.63	15.82	16	47774	2144	42571401
Symptom masked	16.50	15.82	11	47779	870	42572675
Long QT syndrome	16.42	15.82	19	47771	3148	42570397
Macroglossia	16.35	15.82	9	47781	503	42573042
Parkinsonism hyperpyrexia syndrome	16.32	15.82	8	47782	351	42573194
Thrombophlebitis	16.22	15.82	21	47769	3905	42569640
Cytomegalovirus infection	16.15	15.82	8	47782	32298	42541247
Basal cell carcinoma	16.08	15.82	3	47787	22730	42550815
Vision blurred	16.08	15.82	22	47768	53677	42519868
Melaena	16.02	15.82	12	47778	38734	42534811
Musculoskeletal stiffness	15.99	15.82	25	47765	57740	42515805
Hypersensitivity	15.93	15.82	137	47653	72233	42501312
Complication of device removal	15.92	15.82	5	47785	64	42573481
Transient ischaemic attack	15.92	15.82	9	47781	33730	42539815
Intra-abdominal haemorrhage	15.91	15.82	18	47772	2910	42570635
Arrhythmia	15.84	15.82	88	47702	40229	42533316

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Anaphylactic shock	6402.90	14.71	2165	89417	49381	110448336
Anaphylactic reaction	2708.38	14.71	1485	90097	112815	110384902
Propofol infusion syndrome	2427.20	14.71	536	91046	2053	110495664
Hypotension	2035.32	14.71	2327	89255	521522	109976195
Cardiac arrest	1880.69	14.71	1445	90137	195308	110302409
Bronchospasm	1510.19	14.71	655	90927	29584	110468133
Hyperthermia malignant	1154.48	14.71	320	91262	3580	110494137
Bradycardia	991.63	14.71	905	90677	154612	110343105
Serotonin syndrome	876.85	14.71	569	91013	58584	110439133
Rhabdomyolysis	867.43	14.71	751	90831	119650	110378067
Tachycardia	802.74	14.71	963	90619	225682	110272035
Delayed recovery from anaesthesia	773.36	14.71	207	91375	2008	110495709
Circulatory collapse	717.96	14.71	446	91136	42547	110455170
Fatigue	579.24	14.71	148	91434	1215810	109281907
Stress cardiomyopathy	551.57	14.71	267	91315	15539	110482178
Status epilepticus	530.81	14.71	329	91253	31242	110466475
Drug interaction	506.97	14.71	1212	90370	498971	109998746
Haemodynamic instability	493.30	14.71	280	91302	22608	110475109
Arthralgia	457.09	14.71	55	91527	779577	109718140
Metabolic acidosis	455.23	14.71	484	91098	99260	110398457
Neuromuscular block prolonged	437.52	14.71	117	91465	1130	110496587
Diarrhoea	415.05	14.71	214	91368	1139291	109358426
Pulseless electrical activity	410.37	14.71	223	91359	16534	110481183
Oxygen saturation decreased	409.52	14.71	574	91008	156408	110341309
Shock	405.35	14.71	344	91238	53244	110444473
Ventricular fibrillation	390.31	14.71	302	91280	41011	110456706
Ventricular tachycardia	382.30	14.71	323	91259	49686	110448031
Anaesthetic complication	371.20	14.71	132	91450	3474	110494243
Hypoxia	370.11	14.71	495	91087	129020	110368697
Multiple organ dysfunction syndrome	362.35	14.71	532	91050	151178	110346539
Procedural hypotension	360.98	14.71	118	91464	2387	110495330
Blood pressure decreased	358.54	14.71	459	91123	114632	110383085
Myoclonus	355.61	14.71	261	91321	32737	110464980
Respiratory depression	346.86	14.71	254	91328	31747	110465970
Diabetes insipidus	346.44	14.71	148	91434	6422	110491295
Joint swelling	340.97	14.71	5	91577	442840	110054877
Electrocardiogram ST segment elevation	335.54	14.71	160	91422	9000	110488717
Blood creatine phosphokinase increased	307.79	14.71	340	91242	72737	110424980
Respiratory acidosis	297.52	14.71	169	91413	13657	110484060
Apnoea	280.87	14.71	162	91420	13477	110484240
Airway complication of anaesthesia	277.44	14.71	72	91510	612	110497105
Cardio-respiratory arrest	270.45	14.71	402	91180	115434	110382283
Headache	267.96	14.71	204	91378	882173	109615544
Nasopharyngitis	265.90	14.71	15	91567	394346	110103371
Laryngospasm	262.24	14.71	110	91472	4558	110493159
Fall	258.12	14.71	89	91493	603393	109894324
Alopecia	255.09	14.71	11	91571	364742	110132975
Weight increased	252.10	14.71	27	91555	419617	110078100
Hypertriglyceridaemia	245.60	14.71	158	91424	15996	110481721
Peripheral swelling	245.27	14.71	25	91557	404009	110093708
Abdominal discomfort	240.04	14.71	24	91558	393834	110103883
Malaise	235.44	14.71	132	91450	671687	109826030
Multiple-drug resistance	235.36	14.71	143	91439	13092	110484625
Dizziness	232.28	14.71	146	91436	698047	109799670
Unwanted awareness during anaesthesia	230.40	14.71	56	91526	353	110497364
Drug intolerance	229.85	14.71	32	91550	406480	110091237
Arteriospasm coronary	228.09	14.71	123	91459	8977	110488740
Type I hypersensitivity	226.05	14.71	109	91473	6284	110491433
Pain in extremity	224.05	14.71	63	91519	487055	110010662
Drug reaction with eosinophilia and systemic symptoms	221.10	14.71	305	91277	81790	110415927
Drug ineffective	218.26	14.71	2063	89519	1518477	108979240
Nausea	217.23	14.71	436	91146	1235254	109262463
Anaphylactoid shock	215.98	14.71	64	91518	922	110496795
Agitation	214.84	14.71	357	91225	112694	110385023
Dystonia	212.39	14.71	174	91408	25631	110472086
Respiratory failure	210.14	14.71	515	91067	214817	110282900
Rheumatoid arthritis	209.58	14.71	9	91573	299604	110198113
Drug ineffective for unapproved indication	207.94	14.71	334	91248	102504	110395213
Decreased appetite	207.17	14.71	68	91514	475778	110021939
Procedural complication	206.19	14.71	112	91470	8293	110489424
Infusion related reaction	204.11	14.71	35	91547	381127	110116590
Arthropathy	203.25	14.71	8	91574	287514	110210203
Negative pressure pulmonary oedema	200.63	14.71	56	91526	643	110497074
Pain	200.39	14.71	301	91281	954654	109543063
Systemic lupus erythematosus	195.11	14.71	3	91579	254335	110243382
Myoglobin urine present	194.06	14.71	58	91524	862	110496855
Hypoventilation	193.57	14.71	106	91476	7975	110489742
Respiratory arrest	193.35	14.71	240	91342	58059	110439658
Post procedural complication	193.11	14.71	167	91415	26491	110471226
Sinusitis	191.88	14.71	14	91568	296674	110201043
Anaesthetic complication neurological	191.66	14.71	59	91523	974	110496743
Intestinal ischaemia	190.35	14.71	135	91447	16044	110481673
Torsade de pointes	189.39	14.71	154	91428	22446	110475271
Generalised tonic-clonic seizure	186.01	14.71	228	91354	54452	110443265
Kounis syndrome	185.56	14.71	93	91489	5832	110491885
Product dose omission issue	180.29	14.71	26	91556	321756	110175961
Trigemino-cardiac reflex	178.61	14.71	47	91535	424	110497293
Swelling	175.74	14.71	38	91544	351003	110146714
Intensive care unit acquired weakness	175.37	14.71	68	91514	2291	110495426
Dyspnoea	168.63	14.71	422	91160	1106450	109391267
Unresponsive to stimuli	165.78	14.71	233	91349	63557	110434160
Glossodynia	164.71	14.71	4	91578	222000	110275717
Postoperative delirium	164.44	14.71	51	91531	864	110496853
Acute respiratory distress syndrome	163.72	14.71	211	91371	52987	110444730
Stomatitis	163.21	14.71	17	91565	270225	110227492
Acute generalised exanthematous pustulosis	161.57	14.71	138	91444	21526	110476191
Contusion	159.96	14.71	8	91574	233353	110264364
Anaphylactoid reaction	159.27	14.71	88	91494	6738	110490979
Hypercapnia	157.05	14.71	104	91478	11055	110486662
Tryptase increased	154.61	14.71	49	91533	894	110496823
Maternal exposure during delivery	154.59	14.71	70	91512	3495	110494222
Asthenia	154.42	14.71	207	91375	688792	109808925
Weight decreased	152.58	14.71	100	91482	467957	110029760
Airway peak pressure increased	150.64	14.71	44	91538	601	110497116
Clonus	149.42	14.71	92	91490	8624	110489093
Wound	148.92	14.71	12	91570	234425	110263292
Pruritus	146.97	14.71	159	91423	581401	109916316
Tachypnoea	146.67	14.71	172	91410	39223	110458494
Allergy test negative	146.35	14.71	39	91543	371	110497346
Opisthotonus	146.28	14.71	45	91537	741	110496976
Electrocardiogram QT prolonged	142.55	14.71	293	91289	108667	110389050
Erythema	141.59	14.71	546	91036	290901	110206816
Toxic epidermal necrolysis	141.21	14.71	203	91379	56524	110441193
Hypoxic-ischaemic encephalopathy	140.61	14.71	89	91493	8758	110488959
Insomnia	139.46	14.71	62	91520	360528	110137189
Seizure	137.14	14.71	449	91133	220736	110276981
Brain oedema	136.64	14.71	148	91434	30950	110466767
Abdominal pain upper	135.05	14.71	60	91522	349051	110148666
Blood cholesterol increased	134.57	14.71	4	91578	184781	110312936
Anticholinergic syndrome	133.50	14.71	67	91515	4213	110493504
Lower respiratory tract infection	133.03	14.71	21	91561	243085	110254632
Musculoskeletal stiffness	132.69	14.71	34	91548	279788	110217929
Pulse absent	130.02	14.71	93	91489	11199	110486518
Partial seizures	129.60	14.71	93	91489	11256	110486461
Vasoplegia syndrome	129.32	14.71	71	91511	5368	110492349
Abdominal pain	126.55	14.71	143	91439	512846	109984871
Dyskinesia	126.44	14.71	183	91399	51263	110446454
Seizure like phenomena	125.44	14.71	54	91528	2387	110495330
Type 2 diabetes mellitus	124.98	14.71	5	91577	177227	110320490
Muscle rigidity	124.66	14.71	125	91457	23906	110473811
Mobility decreased	124.43	14.71	23	91559	237399	110260318
Sinus tachycardia	122.32	14.71	167	91415	44326	110453391
Mydriasis	121.88	14.71	119	91463	22038	110475679
Irritable bowel syndrome	121.65	14.71	3	91579	164212	110333505
Arthritis	120.70	14.71	4	91578	167582	110330135
Necrosis ischaemic	118.44	14.71	44	91538	1315	110496402
Gastrointestinal disorder	117.43	14.71	28	91554	241924	110255793
Impaired healing	117.16	14.71	13	91569	196704	110301013
Premature delivery	116.13	14.71	135	91447	30497	110467220
Electrocardiogram QRS complex prolonged	116.05	14.71	92	91490	12929	110484788
Disseminated intravascular coagulation	115.07	14.71	156	91426	41130	110456587
Labile blood pressure	115.07	14.71	51	91531	2420	110495297
Pulmonary oedema	114.76	14.71	256	91326	100403	110397314
Dry mouth	114.69	14.71	15	91567	199933	110297784
Blood lactic acid increased	114.36	14.71	99	91483	15722	110481995
Cardiogenic shock	114.18	14.71	185	91397	57153	110440564
Fibromyalgia	113.59	14.71	7	91575	170902	110326815
Constipation	110.50	14.71	81	91501	357705	110140012
Inappropriate schedule of product administration	110.49	14.71	18	91564	203619	110294098
Dyspepsia	110.32	14.71	14	91568	190951	110306766
Endotracheal intubation complication	109.92	14.71	37	91545	822	110496895
Stridor	108.67	14.71	69	91513	6826	110490891
Electroencephalogram abnormal	107.96	14.71	66	91516	6107	110491610
Coagulopathy	107.13	14.71	150	91432	40761	110456956
Contraindicated product administered	107.03	14.71	36	91546	248231	110249486
Neuromuscular blockade	107.01	14.71	35	91547	709	110497008
Fear	106.51	14.71	113	91469	23080	110474637
Mechanical ventilation complication	105.79	14.71	35	91547	736	110496981
PCO2 increased	105.76	14.71	45	91537	1932	110495785
Asthma	104.96	14.71	38	91544	250253	110247464
Musculoskeletal pain	104.32	14.71	14	91568	183009	110314708
General physical health deterioration	103.29	14.71	120	91462	425175	110072542
Injection site pain	102.88	14.71	13	91569	177909	110319808
Discomfort	101.94	14.71	26	91556	214681	110283036
Acute kidney injury	101.49	14.71	884	90698	634546	109863171
Infection	100.65	14.71	91	91491	362109	110135608
Mitochondrial DNA mutation	100.36	14.71	30	91552	446	110497271
Renal injury	100.13	14.71	99	91483	18614	110479103
Laryngeal oedema	99.87	14.71	75	91507	9732	110487985
Recurrence of neuromuscular blockade	98.89	14.71	29	91553	402	110497315
Psoriasis	98.53	14.71	4	91578	139989	110357728
Cyanosis	97.89	14.71	122	91460	29619	110468098
Atrioventricular block complete	97.86	14.71	101	91481	19981	110477736
Resuscitation	97.66	14.71	48	91534	2885	110494832
Renal failure	97.61	14.71	409	91173	226165	110271552
Rash maculo-papular	97.54	14.71	200	91382	74022	110423695
Acute pulmonary oedema	96.71	14.71	93	91489	16903	110480814
Chest pain	95.99	14.71	102	91480	376273	110121444
Sinus arrest	94.36	14.71	53	91529	4189	110493528
Sinus bradycardia	93.95	14.71	119	91463	29364	110468353
Ventricular arrhythmia	93.63	14.71	73	91509	10014	110487703
Amylase increased	91.83	14.71	79	91503	12440	110485277
Muscle spasms	91.15	14.71	59	91523	278098	110219619
Brugada syndrome	91.14	14.71	38	91544	1550	110496167
Hypoaesthesia	90.86	14.71	76	91506	314147	110183570
Product contamination microbial	90.17	14.71	34	91548	1060	110496657
Oedema peripheral	89.61	14.71	84	91498	328576	110169141
Hyperthermia	89.56	14.71	99	91483	21173	110476544
Suspected product quality issue	89.48	14.71	29	91553	570	110497147
Oliguria	89.42	14.71	93	91489	18564	110479153
Influenza	89.41	14.71	16	91566	169085	110328632
Malignant neoplasm progression	89.15	14.71	18	91564	174549	110323168
Intra-abdominal pressure increased	88.95	14.71	26	91556	356	110497361
Hyperkalaemia	88.95	14.71	281	91301	135515	110362202
Gait disturbance	88.49	14.71	61	91521	278147	110219570
Priapism	88.28	14.71	57	91525	5804	110491913
Anaesthetic complication pulmonary	88.27	14.71	22	91560	156	110497561
Muscle injury	87.24	14.71	8	91574	140799	110356918
Ill-defined disorder	87.05	14.71	13	91569	156840	110340877
Loss of personal independence in daily activities	86.64	14.71	11	91571	150009	110347708
Neuropathy peripheral	86.48	14.71	21	91561	179256	110318461
Neuroleptic malignant syndrome	86.39	14.71	123	91459	33936	110463781
Urinary tract infection	85.93	14.71	86	91496	326196	110171521
Hospitalisation	85.91	14.71	9	91573	142484	110355233
Depression	85.47	14.71	82	91500	317253	110180464
Sleep disorder	85.27	14.71	29	91553	198615	110299102
Migraine	85.00	14.71	19	91563	171633	110326084
Bronchitis	84.91	14.71	14	91568	157018	110340699
Acidosis	84.91	14.71	99	91483	22432	110475285
Coma	84.75	14.71	252	91330	117617	110380100
Ventricular extrasystoles	84.52	14.71	99	91483	22542	110475175
Disease progression	83.79	14.71	49	91533	243985	110253732
Shock haemorrhagic	83.71	14.71	108	91474	27139	110470578
Death	83.38	14.71	298	91284	698571	109799146
Hepatorenal failure	82.99	14.71	34	91548	1326	110496391
Septic shock	82.96	14.71	303	91279	157225	110340492
Toxic encephalopathy	82.35	14.71	81	91501	15133	110482584
Phrenic nerve paralysis	81.95	14.71	27	91555	560	110497157
Anhedonia	81.40	14.71	81	91501	15347	110482370
Neutropenia	81.32	14.71	115	91467	374505	110123212
Brain injury	80.98	14.71	76	91506	13400	110484317
Joint range of motion decreased	80.92	14.71	5	91577	121827	110375890
Skin test positive	80.90	14.71	34	91548	1415	110496302
Therapeutic product effect prolonged	80.46	14.71	28	91554	690	110497027
Encephalopathy	80.17	14.71	195	91387	80860	110416857
Angioedema	79.95	14.71	220	91362	98280	110399437
Procedural haemorrhage	79.83	14.71	52	91530	5375	110492342
Depressed level of consciousness	79.73	14.71	239	91343	112039	110385678
Febrile neutropenia	79.47	14.71	87	91495	316680	110181037
Cough	78.08	14.71	166	91416	461475	110036242
Gastrooesophageal reflux disease	77.73	14.71	26	91556	179950	110317767
Obesity	77.29	14.71	4	91578	113347	110384370
Pneumonia	77.22	14.71	419	91163	876295	109621422
Tracheal deviation	77.04	14.71	22	91560	276	110497441
Night sweats	76.95	14.71	10	91572	133973	110363744
Upper airway obstruction	76.93	14.71	35	91547	1767	110495950
Endotracheal intubation	76.30	14.71	53	91529	6091	110491626
Hepatic failure	76.30	14.71	173	91409	68566	110429151
Myocardial depression	76.11	14.71	27	91555	705	110497012
White blood cell count decreased	76.04	14.71	48	91534	229342	110268375
Posterior reversible encephalopathy syndrome	75.38	14.71	115	91467	33746	110463971
Eosinophilia	74.81	14.71	155	91427	57781	110439936
Spinal muscular atrophy	73.38	14.71	23	91559	404	110497313
Phaeochromocytoma crisis	73.20	14.71	24	91558	490	110497227
Hepatic enzyme increased	73.18	14.71	95	91487	320797	110176920
Feeling abnormal	73.14	14.71	29	91553	180682	110317035
Oculogyric crisis	72.26	14.71	43	91539	3789	110493928
Acute hepatic failure	71.70	14.71	117	91465	36351	110461366
Hepatocellular injury	70.75	14.71	140	91442	50502	110447215
Lactic acidosis	70.14	14.71	202	91380	92609	110405108
Atrioventricular block	70.11	14.71	78	91504	16799	110480918
Arrhythmia	69.47	14.71	168	91414	69407	110428310
COVID-19	68.73	14.71	61	91521	244999	110252718
Pulmonary alveolar haemorrhage	68.47	14.71	84	91498	20066	110477651
Post procedural haemorrhage	68.44	14.71	74	91508	15438	110482279
Confusion postoperative	68.20	14.71	21	91561	347	110497370
Osteoarthritis	68.08	14.71	33	91549	182590	110315127
Drug withdrawal syndrome	68.03	14.71	117	91465	37937	110459780
Systemic inflammatory response syndrome	67.93	14.71	68	91514	12975	110484742
Pseudocholinesterase deficiency	67.92	14.71	19	91563	220	110497497
Hyperreflexia	67.84	14.71	59	91523	9426	110488291
Extravasation	67.80	14.71	45	91537	4800	110492917
Pneumothorax	67.74	14.71	112	91470	35173	110462544
Haemodialysis	67.01	14.71	78	91504	17641	110480076
Post procedural fever	67.00	14.71	24	91558	645	110497072
Blister	66.95	14.71	54	91528	227322	110270395
Anaemia	66.73	14.71	231	91351	546855	109950862
Renal impairment	66.72	14.71	321	91261	188124	110309593
Face oedema	66.64	14.71	108	91474	33361	110464356
Back pain	66.46	14.71	129	91453	370867	110126850
Respiratory distress	66.31	14.71	164	91418	68710	110429007
Acute postoperative sialadenitis	65.85	14.71	15	91567	68	110497649
Electrocardiogram ST segment depression	65.23	14.71	46	91536	5415	110492302
Autonomic nervous system imbalance	65.16	14.71	47	91535	5733	110491984
Emotional distress	65.11	14.71	126	91456	44721	110452996
Local anaesthetic systemic toxicity	64.66	14.71	46	91536	5491	110492226
Supraventricular tachycardia	64.61	14.71	90	91492	24332	110473385
Blood pH decreased	64.46	14.71	43	91539	4626	110493091
Chromaturia	64.35	14.71	99	91483	29261	110468456
Carcinoid crisis	63.57	14.71	22	91560	533	110497184
CSF oligoclonal band present	63.06	14.71	21	91561	451	110497266
Paraesthesia	62.90	14.71	82	91500	276439	110221278
PO2 increased	62.54	14.71	29	91553	1530	110496187
Herpes zoster	62.45	14.71	8	91574	108371	110389346
Transcranial electrical motor evoked potential monitoring abnormal	62.31	14.71	13	91569	35	110497682
Intentional product use issue	62.26	14.71	68	91514	247838	110249879
Neck pain	62.23	14.71	13	91569	123117	110374600
Hypovolaemia	62.07	14.71	83	91499	21591	110476126
Acidosis hyperchloraemic	62.06	14.71	29	91553	1557	110496160
Gait inability	61.93	14.71	18	91564	136358	110361359
Vomiting	61.88	14.71	471	91111	910204	109587513
Hepatitis acute	61.79	14.71	77	91505	18689	110479028
Anaesthetic complication cardiac	61.79	14.71	15	91567	94	110497623
Unmasking of previously unidentified disease	61.54	14.71	35	91547	2833	110494884
Ventricular hypokinesia	61.25	14.71	60	91522	11154	110486563
Ischaemic cerebral infarction	60.68	14.71	35	91547	2910	110494807
Blood gases abnormal	59.95	14.71	27	91555	1331	110496386
Nasal congestion	59.78	14.71	6	91576	98276	110399441
Dry skin	59.55	14.71	9	91573	107644	110390073
Paralysis	59.54	14.71	69	91513	15531	110482186
Hypothermia	59.50	14.71	90	91492	26212	110471505
Road traffic accident	59.36	14.71	9	91573	107389	110390328
Increased bronchial secretion	58.49	14.71	38	91544	3910	110493807
Wound infection	58.38	14.71	6	91576	96459	110401258
End-tidal CO2 decreased	58.19	14.71	14	91568	84	110497633
Myoclonic epilepsy	58.18	14.71	33	91549	2658	110495059
Brain death	57.63	14.71	46	91536	6527	110491190
Cardiac output decreased	57.60	14.71	30	91552	2039	110495678
Hypotonia	57.36	14.71	68	91514	15677	110482040
C-reactive protein increased	56.71	14.71	58	91524	217861	110279856
Hypocapnia	56.09	14.71	23	91559	899	110496818
Mixed liver injury	55.72	14.71	59	91523	12020	110485697
Dehydration	55.62	14.71	91	91491	279420	110218297
Drug level changed	53.76	14.71	20	91562	600	110497117
Exposure during pregnancy	53.46	14.71	277	91305	167147	110330570
Upper respiratory tract infection	53.26	14.71	21	91561	131307	110366410
Wrong product administered	53.18	14.71	55	91527	10905	110486812
Nephrogenic diabetes insipidus	52.90	14.71	30	91552	2415	110495302
Red blood cell sedimentation rate increased	52.65	14.71	3	91579	78299	110419418
Hepatic ischaemia	52.46	14.71	24	91558	1227	110496490
Overdose	52.17	14.71	352	91230	233442	110264275
Inflammation	51.93	14.71	50	91532	193188	110304529
Renal ischaemia	51.61	14.71	29	91553	2294	110495423
Lung disorder	51.46	14.71	44	91538	180003	110317714
Subcutaneous emphysema	51.36	14.71	30	91552	2554	110495163
Alanine aminotransferase increased	51.23	14.71	293	91289	183480	110314237
Pneumatosis	50.96	14.71	22	91560	979	110496738
Product contamination	50.92	14.71	27	91555	1904	110495813
Chest discomfort	50.28	14.71	42	91540	173806	110323911
Adverse event	50.07	14.71	14	91568	108795	110388922
Hepatic cytolysis	49.77	14.71	128	91454	54925	110442792
Myoglobinuria	49.75	14.71	23	91559	1205	110496512
Myelosuppression	49.70	14.71	9	91573	94331	110403386
Pulmonary fibrosis	49.11	14.71	12	91570	102030	110395687
Hypernatraemia	49.10	14.71	67	91515	17766	110479951
Macroglossia	48.91	14.71	24	91558	1437	110496280
Mucosal inflammation	48.90	14.71	10	91572	96131	110401586
Osteoporosis	48.86	14.71	7	91575	87145	110410572
Blood triglycerides increased	48.72	14.71	78	91504	23848	110473869
Troponin increased	48.66	14.71	88	91494	29678	110468039
Product use issue	48.65	14.71	117	91465	311578	110186139
Grip strength decreased	48.48	14.71	5	91577	80169	110417548
Atelectasis	48.31	14.71	99	91483	36613	110461104
Hyperammonaemia	47.88	14.71	58	91524	13674	110484043
Blood pressure immeasurable	47.81	14.71	28	91554	2395	110495322
Unevaluable event	47.77	14.71	132	91450	59095	110438622
Injection site erythema	47.48	14.71	10	91572	94166	110403551
Therapeutic product effect incomplete	47.25	14.71	70	91512	223735	110273982
Delirium	47.05	14.71	229	91353	134796	110362921
Post procedural hypotension	46.99	14.71	12	91570	95	110497622
Mean arterial pressure decreased	46.87	14.71	17	91565	474	110497243
Acute respiratory failure	46.78	14.71	153	91429	75107	110422610
Chronic obstructive pulmonary disease	46.72	14.71	16	91566	109142	110388575
Toxicity to various agents	46.62	14.71	605	90977	479950	110017767
Peripheral venous disease	46.60	14.71	7	91575	84110	110413607
Pancreatitis acute	46.32	14.71	132	91450	60142	110437575
Areflexia	46.20	14.71	41	91541	6728	110490989
Oedema	45.98	14.71	64	91518	209912	110287805
Nystagmus	45.52	14.71	52	91530	11525	110486192
Ventricular asystole	45.28	14.71	16	91566	413	110497304
Illness	45.15	14.71	7	91575	82164	110415553
Oxygen saturation immeasurable	44.64	14.71	11	91571	74	110497643
Procedural hypertension	44.53	14.71	15	91567	334	110497383
Bradyarrhythmia	44.26	14.71	35	91547	4899	110492818
Palpitations	44.18	14.71	40	91542	159172	110338545
End-tidal CO2 increased	44.15	14.71	10	91572	44	110497673
Motor neurone disease	43.84	14.71	18	91564	706	110497011
Suspected product contamination	43.79	14.71	14	91568	263	110497454
Nodal rhythm	43.62	14.71	30	91552	3393	110494324
Gene mutation	43.57	14.71	30	91552	3399	110494318
Mental status changes postoperative	43.32	14.71	13	91569	196	110497521
Dyspnoea exertional	43.26	14.71	16	91566	104044	110393673
Hypercholesterolaemia	43.10	14.71	11	91571	90826	110406891
Air embolism	42.49	14.71	17	91565	623	110497094
Taste disorder	42.48	14.71	3	91579	65384	110432333
Prescribed underdose	42.32	14.71	3	91579	65171	110432546
Foetal death	42.25	14.71	59	91523	15986	110481731
Mechanical ventilation	42.18	14.71	29	91553	3278	110494439
Diabetes mellitus	41.79	14.71	15	91567	99366	110398351
Stoma closure	41.78	14.71	15	91567	406	110497311
Anti factor V antibody	41.72	14.71	14	91568	308	110497409
Left ventricle outflow tract obstruction	41.60	14.71	16	91566	527	110497190
Colitis ulcerative	41.59	14.71	7	91575	77356	110420361
Muscle relaxant therapy	41.35	14.71	12	91570	160	110497557
Memory impairment	40.22	14.71	63	91519	196881	110300836
Fluid retention	40.06	14.71	14	91568	94293	110403424
Injection site reaction	39.99	14.71	12	91570	89058	110408659
Blood lactate dehydrogenase increased	39.99	14.71	103	91479	44231	110453486
Cardiovascular insufficiency	39.98	14.71	28	91554	3260	110494457
Haematochezia	39.91	14.71	23	91559	115501	110382216
Pneumococcal sepsis	39.58	14.71	24	91558	2188	110495529
Balance disorder	39.15	14.71	24	91558	116536	110381181
Haemothorax	39.11	14.71	38	91544	6993	110490724
Pancreatitis necrotising	38.90	14.71	34	91548	5467	110492250
Thyrotoxic crisis	38.75	14.71	23	91559	2017	110495700
Treatment failure	38.73	14.71	110	91472	277124	110220593
Joint stiffness	38.65	14.71	5	91577	67238	110430479
Leukocytosis	38.59	14.71	115	91467	53713	110444004
Anuria	38.57	14.71	71	91511	24270	110473447
Syncope	38.39	14.71	68	91514	202468	110295249
Premature recovery from anaesthesia	38.35	14.71	7	91575	6	110497711
Bispectral index decreased	38.35	14.71	7	91575	6	110497711
Oxygen saturation abnormal	38.32	14.71	34	91548	5577	110492140
Urticaria	38.18	14.71	418	91164	318439	110179278
Cholestasis	38.17	14.71	129	91453	64389	110433328
Hepatitis fulminant	38.05	14.71	41	91541	8519	110489198
Myoglobin blood increased	37.92	14.71	30	91552	4202	110493515
Hepatorenal syndrome	37.82	14.71	31	91551	4566	110493151
Neutrophil count decreased	37.79	14.71	27	91555	120914	110376803
Symmetrical drug-related intertriginous and flexural exanthema	37.64	14.71	22	91560	1875	110495842
Rhinorrhoea	37.57	14.71	19	91563	102647	110395070
Altered state of consciousness	37.48	14.71	119	91463	57507	110440210
Methaemoglobinaemia	37.44	14.71	42	91540	9126	110488591
Hyperlactacidaemia	37.38	14.71	40	91542	8246	110489471
Abdominal compartment syndrome	37.32	14.71	22	91560	1905	110495812
Hypertensive crisis	37.25	14.71	70	91512	24302	110473415
Pleocytosis	36.89	14.71	21	91561	1703	110496014
Pneumonia aspiration	36.80	14.71	149	91433	81084	110416633
Chills	36.72	14.71	277	91305	190303	110307414
Neoplasm progression	36.66	14.71	5	91577	64590	110433127
Depressed mood	36.24	14.71	4	91578	60805	110436912
Post-injection delirium sedation syndrome	36.22	14.71	16	91566	753	110496964
Inspiratory capacity decreased	36.07	14.71	24	91558	2571	110495146
Locked-in syndrome	36.00	14.71	17	91565	935	110496782
Skin test negative	35.85	14.71	9	91573	66	110497651
Maternal exposure during pregnancy	35.68	14.71	345	91237	254538	110243179
Tonic clonic movements	35.57	14.71	25	91557	2927	110494790
Eye movement disorder	35.42	14.71	42	91540	9686	110488031
Inadequate aseptic technique in use of product	35.35	14.71	10	91572	121	110497596
Atrioventricular dissociation	35.23	14.71	13	91569	381	110497336
Respiratory tract infection bacterial	35.17	14.71	23	91559	2393	110495324
Long QT syndrome	35.04	14.71	36	91546	7082	110490635
Suicidal ideation	34.96	14.71	17	91565	93920	110403797
Systolic anterior motion of mitral valve	34.84	14.71	9	91573	75	110497642
Ileus	34.83	14.71	78	91504	30651	110467066
Bone pain	34.77	14.71	6	91576	65127	110432590
Gaze palsy	34.57	14.71	26	91556	3381	110494336
Metabolic disorder	34.40	14.71	43	91539	10467	110487250
Acute lung injury	34.11	14.71	25	91557	3126	110494591
Cardiac failure congestive	34.09	14.71	45	91537	150955	110346762
Oropharyngeal pain	34.07	14.71	37	91545	135239	110362478
Prinzmetal angina	34.01	14.71	22	91560	2247	110495470
Productive cough	33.81	14.71	27	91555	114278	110383439
Polyuria	33.64	14.71	56	91526	17682	110480035
Trismus	33.64	14.71	34	91548	6562	110491155
Ultrasound ovary abnormal	33.55	14.71	9	91573	88	110497629
Allergy test positive	33.43	14.71	16	91566	907	110496810
Respiratory tract infection	33.35	14.71	9	91573	71608	110426109
Perforation	33.32	14.71	20	91562	1790	110495927
Clonic convulsion	33.15	14.71	19	91563	1561	110496156
Vocal cord dysfunction	32.99	14.71	16	91566	934	110496783
Atrioventricular block second degree	32.60	14.71	37	91545	8144	110489573
Apnoeic attack	32.25	14.71	15	91567	797	110496920
Extrasystoles	32.09	14.71	37	91545	8281	110489436
Brain herniation	31.83	14.71	38	91544	8825	110488892
Myoglobinaemia	31.78	14.71	10	91572	178	110497539
Myotonia	31.76	14.71	11	91571	267	110497450
Rash morbilliform	31.75	14.71	36	91546	7915	110489802
Ventricular dysfunction	31.69	14.71	35	91547	7476	110490241
Heparin-induced thrombocytopenia	31.57	14.71	43	91539	11381	110486336
Cystitis	31.32	14.71	8	91574	66028	110431689
Intracranial pressure increased	31.18	14.71	41	91541	10494	110487223
Myxoedema coma	31.12	14.71	14	91568	688	110497029
Plasma cell myeloma	31.08	14.71	7	91575	62929	110434788
Pancytopenia	30.89	14.71	81	91501	209532	110288185
Oculocardiac reflex	30.87	14.71	9	91573	122	110497595
Tongue oedema	30.64	14.71	36	91546	8220	110489497
Coma scale abnormal	30.58	14.71	39	91543	9687	110488030
Intestinal pseudo-obstruction	30.52	14.71	24	91558	3332	110494385
Electrocardiogram ST-T segment elevation	30.49	14.71	5	91577	0	110497717
Visual impairment	30.41	14.71	40	91542	134388	110363329
Sedation complication	30.31	14.71	57	91525	19798	110477919
Eyelid oedema	30.04	14.71	49	91533	15213	110482504
Symptom masked	29.95	14.71	19	91563	1876	110495841
Laryngeal stenosis	29.83	14.71	17	91565	1381	110496336
Blood bicarbonate decreased	29.78	14.71	30	91552	5767	110491950
Pupil fixed	29.74	14.71	25	91557	3813	110493904
Coma blister	29.72	14.71	10	91572	222	110497495
Aspiration	29.70	14.71	73	91509	30460	110467257
Cerebral ischaemia	29.65	14.71	43	91539	12061	110485656
Dialysis	29.55	14.71	56	91526	19563	110478154
Burkholderia test positive	29.44	14.71	13	91569	611	110497106
Therapeutic product effect decreased	29.17	14.71	104	91478	244212	110253505
Periorbital oedema	29.14	14.71	39	91543	10153	110487564
Mouth ulceration	29.11	14.71	3	91579	48135	110449582
Irregular breathing	29.11	14.71	13	91569	628	110497089
Vertigo	29.02	14.71	18	91564	86852	110410865
Cellulitis	29.02	14.71	37	91545	125979	110371738
Tachyarrhythmia	28.98	14.71	35	91547	8226	110489491
Wheezing	28.93	14.71	111	91471	255119	110242598
Rectal haemorrhage	28.84	14.71	34	91548	119799	110377918
Hepatitis	28.73	14.71	149	91433	89905	110407812
Eczema	28.59	14.71	12	91570	72281	110425436
Haematuria traumatic	28.55	14.71	11	91571	364	110497353
Conversion disorder	28.39	14.71	20	91562	2350	110495367
Aspartate aminotransferase increased	28.34	14.71	228	91354	159708	110338009
Left ventricular dysfunction	28.17	14.71	61	91521	23432	110474285
Sputum increased	28.16	14.71	29	91553	5722	110491995
Blood pressure measurement	28.14	14.71	12	91570	518	110497199
Viral infection	28.14	14.71	5	91577	53134	110444583
Lower respiratory tract infection bacterial	28.13	14.71	15	91567	1070	110496647
Procedure aborted	28.01	14.71	9	91573	172	110497545
Spinal cord infarction	27.96	14.71	15	91567	1083	110496634
Disease complication	27.84	14.71	29	91553	5798	110491919
Blood potassium increased	27.70	14.71	75	91507	33174	110464543
Vision blurred	27.57	14.71	40	91542	128982	110368735
Bezold-Jarisch reflex	27.57	14.71	7	91575	54	110497663
Adverse drug reaction	27.56	14.71	28	91554	105531	110392186
Epilepsy with myoclonic-atonic seizures	27.47	14.71	8	91574	108	110497609
Incorrect drug administration rate	27.37	14.71	28	91554	5480	110492237
Blepharospasm	27.29	14.71	6	91576	54845	110442872
Myocardial ischaemia	27.24	14.71	65	91517	26619	110471098
Torticollis	27.09	14.71	22	91560	3199	110494518
Chemical peritonitis	27.04	14.71	10	91572	295	110497422
Circumoral oedema	26.94	14.71	11	91571	425	110497292
Hyperdynamic left ventricle	26.86	14.71	12	91570	580	110497137
Respiratory alkalosis	26.49	14.71	28	91554	5693	110492024
Fibrinolysis	26.42	14.71	7	91575	65	110497652
Paraplegia	26.35	14.71	29	91553	6171	110491546
Superinfection	26.32	14.71	28	91554	5735	110491982
Multiple sclerosis relapse	26.02	14.71	5	91577	50235	110447482
Pigment nephropathy	25.95	14.71	7	91575	70	110497647
Toxic skin eruption	25.93	14.71	65	91517	27450	110470267
Change in seizure presentation	25.85	14.71	13	91569	821	110496896
Cataract	25.82	14.71	17	91565	79468	110418249
Haemodilution	25.82	14.71	8	91574	135	110497582
Atrioventricular block first degree	25.77	14.71	44	91538	14181	110483536
Hyponatraemia	25.75	14.71	93	91489	217560	110280157
Bronchial disorder	25.57	14.71	20	91562	2756	110494961
Transaminases increased	25.39	14.71	112	91470	63278	110434439
Hyperbilirubinaemia	25.37	14.71	69	91513	30602	110467115
Piloerection	25.34	14.71	13	91569	856	110496861
Stevens-Johnson syndrome	25.33	14.71	91	91491	46810	110450907
Angina pectoris	25.19	14.71	10	91572	62285	110435432
Hypotensive transfusion reaction	25.11	14.71	7	91575	80	110497637
Congestive hepatopathy	24.97	14.71	26	91556	5194	110492523
Chorea	24.92	14.71	21	91561	3214	110494503
Product administered to patient of inappropriate age	24.91	14.71	32	91550	8004	110489713
Continuous haemodiafiltration	24.75	14.71	17	91565	1918	110495799
Orthostatic hypotension	24.63	14.71	12	91570	66237	110431480
Skin ulcer	24.48	14.71	11	91571	63634	110434083
Intra-abdominal haemorrhage	24.48	14.71	26	91556	5316	110492401
Muscle twitching	24.42	14.71	67	91515	29868	110467849
Osteonecrosis of jaw	24.40	14.71	5	91577	48012	110449705
Long QT syndrome congenital	24.23	14.71	8	91574	167	110497550
Electrocardiogram repolarisation abnormality	24.09	14.71	18	91564	2317	110495400
Dysgeusia	24.08	14.71	14	91568	69971	110427746
Extrapyramidal disorder	23.93	14.71	65	91517	28802	110468915
Mucosal ulceration	23.79	14.71	18	91564	2361	110495356
Tonic convulsion	23.77	14.71	20	91562	3054	110494663
Language disorder	23.74	14.71	22	91560	3816	110493901
Palmar-plantar erythrodysaesthesia syndrome	23.70	14.71	3	91579	41022	110456695
Confusional arousal	23.59	14.71	8	91574	182	110497535
Chest X-ray abnormal	23.54	14.71	32	91550	8455	110489262
Postoperative respiratory distress	23.32	14.71	5	91577	16	110497701
Oesophageal intramural haematoma	23.30	14.71	8	91574	189	110497528
Subdural effusion	23.30	14.71	7	91575	106	110497611
Confusional state	23.25	14.71	262	91320	468418	110029299
Supraventricular extrasystoles	23.24	14.71	31	91551	8042	110489675
Catatonia	23.23	14.71	37	91545	11263	110486454
Nephrolithiasis	23.13	14.71	13	91569	66199	110431518
Prescribed overdose	23.13	14.71	23	91559	87558	110410159
Multiple use of single-use product	23.03	14.71	14	91568	1282	110496435
Hot flush	23.02	14.71	13	91569	66023	110431694
Electrocardiogram abnormal	22.92	14.71	49	91533	18660	110479057
Cardiac massage	22.87	14.71	5	91577	18	110497699
Scoliosis	22.83	14.71	32	91550	8701	110489016
Paradoxical drug reaction	22.78	14.71	34	91548	9783	110487934
Sepsis syndrome	22.76	14.71	15	91567	1581	110496136
Pregnancy	22.71	14.71	7	91575	51060	110446657
Brain stem syndrome	22.61	14.71	14	91568	1325	110496392
Myalgia	22.53	14.71	101	91481	222280	110275437
Aggression	22.50	14.71	103	91479	59107	110438610
Basal cell carcinoma	22.42	14.71	5	91577	45265	110452452
Hyperammonaemic encephalopathy	22.37	14.71	25	91557	5409	110492308
Motor dysfunction	22.32	14.71	57	91525	24349	110473368
Myocardial stunning	22.31	14.71	9	91573	337	110497380
Blood pressure systolic decreased	22.30	14.71	40	91542	13401	110484316
Haemoglobin decreased	22.28	14.71	118	91464	248609	110249108
Neurological decompensation	22.27	14.71	28	91554	6855	110490862
Hyperventilation	22.23	14.71	32	91550	8915	110488802
Coronary artery embolism	22.21	14.71	9	91573	341	110497376
Pneumomediastinum	22.17	14.71	24	91558	5012	110492705
Fear of death	22.17	14.71	15	91567	1652	110496065
Non-cardiogenic pulmonary oedema	22.06	14.71	16	91566	1968	110495749
Bradycardia foetal	22.02	14.71	7	91575	129	110497588
Agitation postoperative	21.98	14.71	6	91576	63	110497654
Cerebral hypoperfusion	21.92	14.71	12	91570	902	110496815
Malignant catatonia	21.87	14.71	11	91571	695	110497022
Vitamin K deficiency	21.83	14.71	12	91570	909	110496808
Injection site swelling	21.78	14.71	12	91570	61778	110435939
Intensive care unit delirium	21.73	14.71	6	91576	66	110497651
Tryptase decreased	21.72	14.71	5	91577	24	110497693
Cardiovascular disorder	21.69	14.71	54	91528	22706	110475011
Administration site extravasation	21.67	14.71	15	91567	1714	110496003
Therapeutic response prolonged	21.62	14.71	4	91578	4	110497713
Lip oedema	21.60	14.71	29	91553	7571	110490146
Procedural nausea	21.43	14.71	13	91569	1186	110496531
Capnogram abnormal	21.15	14.71	4	91578	5	110497712
Limb injury	21.15	14.71	3	91579	37633	110460084
Lung consolidation	21.12	14.71	34	91548	10442	110487275
Pantoea agglomerans infection	21.08	14.71	7	91575	149	110497568
Blood bilirubin increased	21.07	14.71	121	91461	75851	110421866
Throat irritation	21.00	14.71	9	91573	53543	110444174
Skin exfoliation	20.95	14.71	25	91557	87626	110410091
Bundle branch block right	20.94	14.71	37	91545	12254	110485463
Monoplegia	20.93	14.71	23	91559	4886	110492831
Burning sensation	20.91	14.71	16	91566	69196	110428521
Dry eye	20.91	14.71	10	91572	55783	110441934
Lymphadenectomy	20.85	14.71	14	91568	1522	110496195
Uterine atony	20.79	14.71	8	91574	264	110497453
Procedural vomiting	20.69	14.71	12	91570	1008	110496709
Transient ischaemic attack	20.36	14.71	14	91568	63968	110433749
Tachyphylaxis	20.33	14.71	9	91573	426	110497291
Tidal volume decreased	20.27	14.71	6	91576	86	110497631
Weaning failure	20.12	14.71	11	91571	825	110496892
No adverse event	20.08	14.71	117	91465	73722	110423995
Phaeochromocytoma	20.00	14.71	11	91571	834	110496883
Quadriparesis	19.97	14.71	22	91560	4685	110493032
Brachial plexopathy	19.87	14.71	8	91574	298	110497419
Electrocardiogram T wave inversion	19.82	14.71	24	91558	5656	110492061
Potentiating drug interaction	19.77	14.71	35	91547	11608	110486109
Administration related reaction	19.65	14.71	8	91574	307	110497410
Extubation	19.65	14.71	5	91577	39	110497678
Euthyroid sick syndrome	19.61	14.71	6	91576	97	110497620
CSWS syndrome	19.53	14.71	5	91577	40	110497677
Encephalitis autoimmune	19.50	14.71	19	91563	3509	110494208
Capillary nail refill test abnormal	19.44	14.71	6	91576	100	110497617
Blood pressure fluctuation	19.36	14.71	20	91562	74804	110422913
Dermatitis bullous	19.31	14.71	44	91538	17485	110480232
Acute myeloid leukaemia	19.30	14.71	4	91578	38106	110459611
Influenza like illness	19.29	14.71	27	91555	88385	110409332
Neuralgia	19.25	14.71	8	91574	48470	110449247
Haemoperitoneum	19.18	14.71	23	91559	5365	110492352
Muscle contracture	19.15	14.71	17	91565	2791	110494926
Coeliac disease	19.06	14.71	6	91576	43181	110454536
Bronchostenosis	18.93	14.71	11	91571	927	110496790
Nerve stimulation test abnormal	18.85	14.71	4	91578	12	110497705
Haemorrhage	18.84	14.71	152	91430	106540	110391177
Underdose	18.81	14.71	15	91567	63539	110434178
Ventricular tachyarrhythmia	18.58	14.71	9	91573	524	110497193
Ammonia increased	18.33	14.71	28	91554	8222	110489495
Biliary cast syndrome	18.29	14.71	3	91579	0	110497717
Fat embolism	18.23	14.71	9	91573	546	110497171
Device programming error	18.22	14.71	8	91574	371	110497346
Femur fracture	18.21	14.71	7	91575	44462	110453255
Cardiotoxicity	18.19	14.71	42	91540	16839	110480878
Transurethral resection syndrome	18.17	14.71	4	91578	15	110497702
Amaurosis	18.09	14.71	13	91569	1576	110496141
Drug hypersensitivity	18.02	14.71	266	91316	453824	110043893
Respiratory rate decreased	17.97	14.71	24	91558	6234	110491483
Pain in jaw	17.95	14.71	10	91572	51167	110446550
Injection site haemorrhage	17.72	14.71	3	91579	33025	110464692
Vasculitis	17.69	14.71	4	91578	35869	110461848
Hypovolaemic shock	17.64	14.71	38	91544	14545	110483172
Klebsiella infection	17.54	14.71	46	91536	19963	110477754
Malabsorption	17.48	14.71	24	91558	6401	110491316
Histamine level increased	17.43	14.71	6	91576	143	110497574
PCO2 decreased	17.42	14.71	17	91565	3144	110494573
Acquired macroglossia	17.38	14.71	7	91575	261	110497456
Metastases to liver	17.34	14.71	4	91578	35382	110462335
Myocardial oedema	17.25	14.71	9	91573	614	110497103
Condition aggravated	17.23	14.71	470	91112	734366	109763351
Cytomegalovirus infection	17.21	14.71	12	91570	54432	110443285
Sepsis	17.18	14.71	373	91209	326973	110170744
Thrombophlebitis	16.97	14.71	26	91556	7653	110490064
Glossoptosis	16.97	14.71	7	91575	278	110497439
Chronic kidney disease	16.95	14.71	23	91559	76268	110421449
Pneumonia staphylococcal	16.94	14.71	23	91559	6068	110491649
Ischaemic hepatitis	16.81	14.71	20	91562	4628	110493089
Pulmonary mass	16.79	14.71	5	91577	37296	110460421
Abdominal pain lower	16.78	14.71	5	91577	37278	110460439
Blood glucose increased	16.76	14.71	55	91527	132441	110365276
Blood creatine phosphokinase MB increased	16.73	14.71	16	91566	2887	110494830
COVID-19 treatment	16.69	14.71	8	91574	455	110497262
Iron deficiency anaemia	16.64	14.71	3	91579	31556	110466161
Hypertonia	16.56	14.71	27	91555	8379	110489338
Hepatic cirrhosis	16.47	14.71	19	91563	67607	110430110
Neurotoxicity	16.47	14.71	74	91508	42133	110455584
Renal tubular necrosis	16.35	14.71	59	91523	30416	110467301
Colitis	16.27	14.71	38	91544	102285	110395432
Hepatic function abnormal	16.19	14.71	128	91454	89167	110408550
Nightmare	16.11	14.71	6	91576	38857	110458860
Gastroenteritis	16.07	14.71	6	91576	38794	110458923
Compartment syndrome	15.96	14.71	22	91560	5888	110491829
Blood catecholamines increased	15.89	14.71	5	91577	89	110497628
Pancreatitis	15.84	14.71	132	91450	93401	110404316
Angiopathy	15.81	14.71	27	91555	8703	110489014
Dysphonia	15.77	14.71	24	91558	75905	110421812
Light anaesthesia	15.75	14.71	3	91579	4	110497713
Myotonic dystrophy	15.73	14.71	6	91576	193	110497524
Urine output decreased	15.73	14.71	44	91538	19832	110477885
Spinal cord injury cervical	15.62	14.71	6	91576	197	110497520
Sudden infant death syndrome	15.60	14.71	7	91575	342	110497375
Jaundice	15.55	14.71	93	91489	59143	110438574
Red blood cell count decreased	15.55	14.71	19	91563	65904	110431813
Disorientation	15.50	14.71	106	91476	70565	110427152
Lymphadenopathy	15.48	14.71	18	91564	63817	110433900
Myopathy toxic	15.45	14.71	11	91571	1314	110496403
Sinus disorder	15.45	14.71	4	91578	32724	110464993
Diabetes mellitus inadequate control	15.34	14.71	3	91579	29772	110467945
Somatosensory evoked potentials abnormal	15.34	14.71	6	91576	207	110497510
Quadriplegia	15.32	14.71	18	91564	4109	110493608
Prostate cancer	15.29	14.71	6	91576	37635	110460082
Neisseria infection	15.28	14.71	6	91576	209	110497508
Retrograde amnesia	15.28	14.71	9	91573	778	110496939
Thrombosis	15.25	14.71	43	91539	108619	110389098
Therapeutic response decreased	15.22	14.71	36	91546	96463	110401254
Hyporeflexia	15.21	14.71	18	91564	4142	110493575
Sputum retention	15.20	14.71	11	91571	1348	110496369
Encephalitis	15.20	14.71	42	91540	18797	110478920
Obstructive airways disorder	15.17	14.71	77	91505	46072	110451645
Intentional self-injury	15.15	14.71	6	91576	37423	110460294
Eyelid contusion	15.12	14.71	5	91577	105	110497612
Blood bromide increased	15.11	14.71	4	91578	37	110497680
Arrhythmia supraventricular	15.09	14.71	14	91568	2432	110495285
Hyporesponsive to stimuli	15.06	14.71	15	91567	2845	110494872
Vasodilatation	15.03	14.71	17	91565	3727	110493990
Tryptase	15.00	14.71	3	91579	6	110497711
Euthanasia	14.99	14.71	6	91576	220	110497497
Therapeutic product effect increased	14.97	14.71	12	91570	1713	110496004
Lymphangiectasia	14.86	14.71	5	91577	111	110497606
Leukopenia	14.81	14.71	68	91514	148723	110348994
Mitochondrial cytopathy	14.77	14.71	7	91575	388	110497329
Tracheal injury	14.72	14.71	6	91576	231	110497486

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N01AX10	NERVOUS SYSTEM ANESTHETICS ANESTHETICS, GENERAL Other general anesthetics
MeSH PA	D000777	Anesthetics
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D006993	Hypnotics and Sedatives
MeSH PA	D018686	Anesthetics, Intravenous
FDA EPC	N0000175681	General Anesthetic
FDA PE	N0000175975	General Anesthesia
CHEBI has role	CHEBI:22587	antiviral agent
CHEBI has role	CHEBI:35469	antidepressant
CHEBI has role	CHEBI:35480	analgesic
CHEBI has role	CHEBI:35554	cardiovascular drug
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:35623	anticonvulsant
CHEBI has role	CHEBI:35674	antihypertensive agent
CHEBI has role	CHEBI:35717	sedative
CHEBI has role	CHEBI:38070	anti-arrhythmia drug
CHEBI has role	CHEBI:38877	intravenous anaesthetic
CHEBI has role	CHEBI:48578	radical scavenger
CHEBI has role	CHEBI:50919	antiemetic
CHEBI has role	CHEBI:62868	hepatoprotective agent
CHEBI has role	CHEBI:63726	neuroprotective agent
CHEBI has role	CHEBI:66981	ophthalmology drug
CHEBI has role	CHEBI:67079	anti-inflammatory agent
CHEBI has role	CHEBI:73336	vulnerary
CHEBI has role	CHEBI:74518	anti-obesity agent

Related Drugs by ATC class:

N01AX Other general anesthetics 8 drugs

alfaxalone esketamine etomidate ketamine nitrous oxide propanidid sodium oxybate xenon

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
General anesthesia	indication	50697003
Sedation in Intubated Patients	indication
Sedation as Adjunct to Anesthesia	indication
Apnea	contraindication	1023001
Asthenia	contraindication	13791008
Hypovolemia	contraindication	28560003
Low blood pressure	contraindication	45007003
Cerebral arteriosclerosis	contraindication	65312002
Decreased respiratory function	contraindication	80954004
Epilepsy	contraindication	84757009	DOID:1826
Myocardial dysfunction	contraindication	233928007
Disorder of lipid metabolism	contraindication	267431006
Hypoxia	contraindication	389086002

🐶 Veterinary Drug Use

Species	Use	Relation
Cats	Anesthesia	Indication
Cats	General anesthesia for short procedures	Indication
Cats	Induction and maintenance of general anesthesia	Indication
Cats	General anesthesia	Indication
Dogs	Anesthesia	Indication
Dogs	General anesthesia for short procedures	Indication
Dogs	Induction and maintenance of general anesthesia	Indication
Dogs	General anesthesia	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Rapanofal	iVaoes Animal Health	1
PropoFlo, PropoFlo 28	Zoetis Inc.	1
PropoClear	Zoetis Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.8	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
GABA-A receptor alpha-1/beta-2/gamma-2	Ion channel	P14867 P18507 P47870	GBRA1_HUMAN GBRG2_HUMAN GBRB2_HUMAN	POSITIVE ALLOSTERIC MODULATOR	EC50	5.70	CHEMBL	CHEMBL
GABA A receptor alpha-2/beta-2/gamma-2	Ion channel	P18507 P47869 P47870	GBRG2_HUMAN GBRA2_HUMAN GBRB2_HUMAN	POSITIVE ALLOSTERIC MODULATOR	EC50	4.95	CHEMBL	CHEMBL
GABA-A receptor alpha-1/beta-3/gamma-2	Ion channel	P14867 P18507 P28472	GBRA1_HUMAN GBRG2_HUMAN GBRB3_HUMAN	POSITIVE ALLOSTERIC MODULATOR	EC50	5.39	CHEMBL	CHEMBL
Transient receptor potential cation channel subfamily V member 1	Ion channel	Q8NER1	TRPV1_HUMAN		IC50	8.30	CHEMBL
Fatty-acid amide hydrolase 1	Enzyme	O00519	FAAH1_HUMAN		IC50	4.28	WOMBAT-PK
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN		IC50	5.42	DRUG MATRIX
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	5.03	DRUG MATRIX
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	5.46	DRUG MATRIX
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	5.22	DRUG MATRIX
Transient receptor potential cation channel subfamily V member 4	Ion channel	Q9HBA0	TRPV4_HUMAN	INHIBITOR	IC50	4.41	IUPHAR
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN		IC50	4.01	WOMBAT-PK
Transient receptor potential cation channel subfamily V member 4	Ion channel	Q9HBA0	TRPV4_HUMAN	INHIBITOR	IC50	4.41	IUPHAR
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN		IC50	4.71	WOMBAT-PK
Cytochrome P450 2C9	Enzyme	P11712	CP2C9_HUMAN		IC50	4.91	WOMBAT-PK
Arachidonate 15-lipoxygenase	Enzyme		LOX15_RABIT		IC50	5.12	DRUG MATRIX
Fatty-acid amide hydrolase 1	Enzyme		FAAH1_RAT		IC50	4.85	CHEMBL
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	Ion channel		HCN1_MOUSE	BLOCKER	IC50	5.20	IUPHAR
GABA-A receptor; anion channel	Ion channel		GBRP_RAT GBRB1_RAT GBRD_RAT GBRG2_RAT GBRA5_RAT GBRA3_RAT GBRG1_RAT GBRA2_RAT GBRA4_RAT GBRG3_RAT GBRA6_RAT GBRA1_RAT GBRB3_RAT GBRB2_RAT Q91ZM7_RAT GBRE_RAT		IC50	5.40	CHEMBL

External reference:

ID	Source
4019500	VUID
N0000147620	NUI
D00549	KEGG_DRUG
4019500	VANDF
C0033487	UMLSCUI
CHEBI:44915	CHEBI
PFL	PDB_CHEM_ID
CHEMBL526	ChEMBL_ID
DB00818	DRUGBANK_ID
D015742	MESH_DESCRIPTOR_UI
4943	PUBCHEM_CID
5073	INN_ID
5464	IUPHAR_LIGAND_ID
YI7VU623SF	UNII
196459	RXNORM
14179	MMSL
5372	MMSL
65	MMSL
d00933	MMSL
003528	NDDF
387423006	SNOMEDCT_US
74674007	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0209	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	31 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0234	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	31 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0248	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	31 sections
Propofol Lipuro	HUMAN PRESCRIPTION DRUG LABEL	1	0264-4850	INJECTION, EMULSION	10 mg	INTRAVENOUS	unapproved drug other	3 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	0409-4699	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	32 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	0409-4699	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	32 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	0409-6010	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	32 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	0409-6010	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	32 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6194	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	27 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6195	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	27 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6196	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	27 sections
propofol	HUMAN PRESCRIPTION DRUG LABEL	1	16714-528	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	26 sections
propofol	HUMAN PRESCRIPTION DRUG LABEL	1	16714-690	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	26 sections
propofol	HUMAN PRESCRIPTION DRUG LABEL	1	16714-977	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	26 sections
propofol	HUMAN PRESCRIPTION DRUG LABEL	1	23155-345	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	26 sections
propofol	HUMAN PRESCRIPTION DRUG LABEL	1	25021-608	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	31 sections
Propofol Injectable Emulsion	HUMAN PRESCRIPTION DRUG LABEL	1	43598-265	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	27 sections
Propofol Injectable Emulsion	HUMAN PRESCRIPTION DRUG LABEL	1	43598-548	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	27 sections
Propofol Injectable Emulsion	HUMAN PRESCRIPTION DRUG LABEL	1	43598-549	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	27 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1293	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	14 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1470	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	14 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1471	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	14 sections
Diprivan	HUMAN PRESCRIPTION DRUG LABEL	1	52584-269	INJECTION, EMULSION	10 mg	INTRAVENOUS	NDA	12 sections
Diprivan	HUMAN PRESCRIPTION DRUG LABEL	1	63323-269	INJECTION, EMULSION	10 mg	INTRAVENOUS	NDA	28 sections
Diprivan	HUMAN PRESCRIPTION DRUG LABEL	1	63323-269	INJECTION, EMULSION	10 mg	INTRAVENOUS	NDA	28 sections
Diprivan	HUMAN PRESCRIPTION DRUG LABEL	1	63323-269	INJECTION, EMULSION	10 mg	INTRAVENOUS	NDA	28 sections
Diprivan	HUMAN PRESCRIPTION DRUG LABEL	1	63323-269	INJECTION, EMULSION	10 mg	INTRAVENOUS	NDA	28 sections
Diprivan	HUMAN PRESCRIPTION DRUG LABEL	1	65219-800	INJECTION, EMULSION	10 mg	INTRAVENOUS	NDA	14 sections
propofol	HUMAN PRESCRIPTION DRUG LABEL	1	71288-729	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	26 sections
propofol	HUMAN PRESCRIPTION DRUG LABEL	1	71288-730	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	26 sections

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General architecture

Using the assistant

propofol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: