propofol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2302	2078-54-8

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: propofol ampofol diprivan disoprofol pofol

An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS. Molecular weight: 178.28 Formula: C12H18O CLOGP: 3.93 LIPINSKI: 0 HAC: 1 HDO: 1 TPSA: 20.23 ALOGS: -3.05 ROTB: 2 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.16 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	14.02 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	4.70 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	36 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.02 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	3.20 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Oct. 2, 1989	FDA	FRESENIUS KABI USA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Anaphylactic shock	2122.65	15.37	718	31892	19556	46633896
Anaphylactic reaction	898.94	15.37	522	32088	52590	46600862
Bronchospasm	681.67	15.37	293	32317	15414	46638038
Hypotension	648.95	15.37	803	31807	231786	46421666
Propofol infusion syndrome	643.07	15.37	141	32469	640	46652812
Cardiac arrest	575.84	15.37	488	32122	89911	46563541
Delayed recovery from anaesthesia	346.49	15.37	87	32523	774	46652678
Circulatory collapse	334.89	15.37	201	32409	21423	46632029
Tachycardia	334.46	15.37	379	32231	99243	46554209
Status epilepticus	320.15	15.37	168	32442	13811	46639641
Serotonin syndrome	299.11	15.37	195	32415	24025	46629427
Hyperthermia malignant	283.17	15.37	72	32538	677	46652775
Bradycardia	276.43	15.37	283	32327	66015	46587437
Respiratory depression	273.02	15.37	142	32468	11458	46641994
Stress cardiomyopathy	238.52	15.37	114	32496	7670	46645782
Fatigue	211.70	15.37	81	32529	608616	46044836
Neuromuscular block prolonged	208.94	15.37	53	32557	493	46652959
Multiple organ dysfunction syndrome	199.78	15.37	212	32398	51498	46601954
Oxygen saturation decreased	190.38	15.37	238	32372	68926	46584526
Ventricular tachycardia	188.65	15.37	128	32482	16839	46636613
Shock	188.03	15.37	141	32469	21704	46631748
Drug interaction	186.65	15.37	427	32183	202667	46450785
Ventricular fibrillation	186.09	15.37	110	32500	11386	46642066
Diarrhoea	185.47	15.37	80	32530	559522	46093930
Arthralgia	179.63	15.37	22	32588	364581	46288871
Blood pressure decreased	169.09	15.37	204	32406	56955	46596497
Procedural hypotension	159.32	15.37	51	32559	1151	46652301
Pulseless electrical activity	155.18	15.37	83	32527	7084	46646368
Anaesthetic complication	153.61	15.37	55	32555	1762	46651690
Apnoea	150.55	15.37	82	32528	7257	46646195
Unwanted awareness during anaesthesia	149.98	15.37	36	32574	260	46653192
Metabolic acidosis	144.46	15.37	156	32454	38624	46614828
Fall	137.37	15.37	31	32579	329066	46324386
Dystonia	134.92	15.37	89	32521	11168	46642284
Anaphylactoid shock	133.64	15.37	33	32577	272	46653180
Rheumatoid arthritis	132.85	15.37	9	32601	240206	46413246
Haemodynamic instability	127.86	15.37	75	32535	7650	46645802
Diabetes insipidus	126.27	15.37	50	32560	2124	46651328
Post procedural complication	123.19	15.37	96	32514	15633	46637819
Procedural complication	114.96	15.37	60	32550	4870	46648582
Rhabdomyolysis	113.29	15.37	143	32467	41766	46611686
Airway complication of anaesthesia	113.09	15.37	27	32583	190	46653262
Laryngospasm	112.82	15.37	50	32560	2823	46650629
Headache	110.74	15.37	103	32507	478249	46175203
Electrocardiogram ST segment elevation	106.78	15.37	52	32558	3643	46649809
Hypoxia	105.36	15.37	154	32456	51684	46601768
Respiratory acidosis	105.21	15.37	61	32549	6087	46647365
Joint swelling	102.23	15.37	3	32607	166070	46487382
Labile blood pressure	101.83	15.37	40	32570	1663	46651789
Anaphylactoid reaction	97.50	15.37	48	32562	3443	46650009
Clonus	96.12	15.37	50	32560	4030	46649422
Malaise	94.98	15.37	57	32553	331175	46322277
Hypoventilation	92.93	15.37	49	32561	4061	46649391
Pain in extremity	91.91	15.37	33	32577	258647	46394805
Dizziness	90.25	15.37	64	32546	340350	46313102
Myoclonus	90.08	15.37	77	32533	14275	46639177
Nausea	89.52	15.37	220	32390	687234	45966218
Product dose omission issue	85.75	15.37	9	32601	168511	46484941
Nasopharyngitis	84.41	15.37	6	32604	153992	46499460
Alopecia	84.40	15.37	8	32602	162406	46491046
PCO2 increased	84.03	15.37	32	32578	1222	46652230
Type I hypersensitivity	83.12	15.37	38	32572	2308	46651144
Tryptase increased	83.10	15.37	21	32589	192	46653260
Drug intolerance	82.75	15.37	5	32605	147044	46506408
Generalised tonic-clonic seizure	82.10	15.37	98	32512	27024	46626428
Renal ischaemia	81.62	15.37	26	32584	577	46652875
Arteriospasm coronary	81.39	15.37	43	32567	3578	46649874
Weight decreased	79.97	15.37	24	32586	210825	46442627
Respiratory failure	79.90	15.37	193	32417	94623	46558829
Transmission of an infectious agent via product	78.44	15.37	18	32592	104	46653348
Unresponsive to stimuli	76.38	15.37	103	32507	32071	46621381
Anticholinergic syndrome	76.00	15.37	33	32577	1773	46651679
Cardiogenic shock	75.63	15.37	74	32536	16310	46637142
Intestinal ischaemia	74.00	15.37	51	32559	6874	46646578
Opisthotonus	73.55	15.37	21	32589	316	46653136
Anaesthetic complication pulmonary	72.28	15.37	15	32595	49	46653403
Oliguria	71.94	15.37	55	32555	8704	46644748
Product contamination	71.72	15.37	23	32587	522	46652930
Mitochondrial DNULL mutation	70.21	15.37	19	32591	232	46653220
Ventricular hypokinesia	68.55	15.37	40	32570	4038	46649414
Dyspnoea	68.51	15.37	163	32447	515385	46138067
Sinusitis	68.46	15.37	6	32604	129762	46523690
Seizure	68.33	15.37	215	32395	122839	46530613
Blood creatine phosphokinase increased	67.71	15.37	90	32520	27634	46625818
Pain	66.41	15.37	147	32463	476801	46176651
Insomnia	65.82	15.37	17	32593	164907	46488545
Respiratory arrest	65.15	15.37	98	32512	33718	46619734
PO2 increased	64.31	15.37	24	32586	866	46652586
Blood gases abnormal	64.24	15.37	22	32588	616	46652836
Weight increased	63.66	15.37	18	32592	164455	46488997
Peripheral swelling	63.64	15.37	16	32594	158055	46495397
Abdominal discomfort	63.43	15.37	14	32596	151151	46502301
Intra-abdominal pressure increased	63.16	15.37	17	32593	203	46653249
Cardio-respiratory arrest	61.67	15.37	132	32478	59737	46593715
Encephalopathy	61.40	15.37	95	32515	33494	46619958
Blood pH decreased	61.33	15.37	32	32578	2595	46650857
Decreased appetite	60.36	15.37	30	32580	193806	46459646
Oculogyric crisis	60.08	15.37	25	32585	1208	46652244
Hyperreflexia	59.24	15.37	40	32570	5214	46648238
Agitation	59.19	15.37	124	32486	55291	46598161
Stridor	58.61	15.37	33	32577	3114	46650338
Drug ineffective for unapproved indication	57.56	15.37	64	32546	16349	46637103
Oxygen saturation abnormal	57.49	15.37	31	32579	2687	46650765
Dyskinesia	57.39	15.37	85	32525	28840	46624612
Constipation	57.20	15.37	25	32585	174072	46479380
Disseminated intravascular coagulation	56.41	15.37	68	32542	18937	46634515
Torsade de pointes	56.29	15.37	55	32555	12099	46641353
Pneumatosis	55.98	15.37	18	32592	412	46653040
Endotracheal intubation complication	55.94	15.37	18	32592	413	46653039
Pulmonary oedema	55.33	15.37	115	32495	50990	46602462
Anaesthetic complication neurological	55.29	15.37	15	32595	185	46653267
Acute respiratory distress syndrome	54.82	15.37	72	32538	21850	46631602
End-tidal CO2 decreased	54.80	15.37	10	32600	12	46653440
Bronchitis	53.02	15.37	6	32604	105973	46547479
Vasoplegia syndrome	52.73	15.37	22	32588	1070	46652382
Erythema	52.39	15.37	218	32392	142602	46510850
Septic shock	52.16	15.37	121	32489	57772	46595680
Carcinoid crisis	51.98	15.37	15	32595	235	46653217
Laryngeal oedema	51.78	15.37	37	32573	5282	46648170
Death	51.21	15.37	98	32512	335450	46318002
Ventricular extrasystoles	51.12	15.37	50	32560	11013	46642439
Exposure during pregnancy	51.07	15.37	179	32431	108033	46545419
Sinus tachycardia	50.91	15.37	69	32541	21580	46631872
Pneumonia	49.87	15.37	119	32491	376201	46277251
Brain oedema	49.62	15.37	52	32558	12426	46641026
Maternal exposure during pregnancy	48.71	15.37	170	32440	102379	46551073
Pruritus	48.28	15.37	59	32551	242293	46411159
Upper airway obstruction	48.12	15.37	17	32593	523	46652929
Atrioventricular block complete	48.02	15.37	41	32569	7586	46645866
Influenza	47.42	15.37	4	32606	89266	46564186
Foetal death	47.05	15.37	43	32567	8700	46644752
Gene mutation	46.31	15.37	20	32590	1060	46652392
Muscle rigidity	45.99	15.37	45	32565	9916	46643536
Acute hepatic failure	45.87	15.37	54	32556	14667	46638785
Hepatic ischaemia	45.36	15.37	16	32594	490	46652962
Postoperative delirium	45.30	15.37	10	32600	47	46653405
Coagulopathy	45.08	15.37	60	32550	18439	46635013
Renal impairment	45.03	15.37	134	32476	74238	46579214
Acute pulmonary oedema	44.81	15.37	40	32570	7851	46645601
Urinary tract infection	44.53	15.37	53	32557	220213	46433239
Arthropathy	44.43	15.37	4	32606	84696	46568756
Electrocardiogram QRS complex prolonged	44.27	15.37	34	32576	5415	46648037
Neuromuscular blockade	43.98	15.37	14	32596	310	46653142
Mydriasis	43.80	15.37	45	32565	10508	46642944
Psoriasis	43.23	15.37	3	32607	78601	46574851
Therapeutic product effect prolonged	43.19	15.37	14	32596	329	46653123
Back pain	43.03	15.37	50	32560	209989	46443463
Gait disturbance	42.96	15.37	24	32586	145239	46508213
Suspected product quality issue	42.90	15.37	12	32598	167	46653285
Multiple-drug resistance	42.69	15.37	25	32585	2540	46650912
Blood bicarbonate decreased	42.52	15.37	26	32584	2859	46650593
Acute generalised exanthematous pustulosis	42.51	15.37	42	32568	9363	46644089
Cardiovascular insufficiency	42.17	15.37	20	32590	1321	46652131
Local anaesthetic systemic toxicity	41.86	15.37	14	32596	364	46653088
Asthenia	41.47	15.37	98	32512	310977	46342475
Contusion	41.23	15.37	6	32604	87481	46565971
Mental status changes postoperative	40.72	15.37	12	32598	203	46653249
Necrosis ischaemic	40.72	15.37	17	32593	828	46652624
Chest pain	40.59	15.37	38	32572	176286	46477166
Product contamination microbial	39.98	15.37	12	32598	217	46653235
Confusion postoperative	39.87	15.37	12	32598	219	46653233
Myoclonic epilepsy	39.28	15.37	17	32593	906	46652546
Acidosis hyperchloraemic	39.27	15.37	13	32597	327	46653125
Electrocardiogram ST segment depression	39.00	15.37	24	32586	2669	46650783
Fear	38.72	15.37	52	32558	16120	46637332
Hepatorenal failure	38.47	15.37	15	32595	611	46652841
Shock haemorrhagic	38.03	15.37	38	32572	8586	46644866
Hepatitis acute	37.72	15.37	37	32573	8177	46645275
Injection site pain	37.43	15.37	14	32596	107138	46546314
Laryngeal stenosis	37.05	15.37	15	32595	675	46652777
Neuropathy peripheral	36.95	15.37	9	32601	90884	46562568
Procedural nausea	36.89	15.37	15	32595	683	46652769
Hepatorenal syndrome	36.52	15.37	20	32590	1788	46651664
Neutropenia	36.46	15.37	28	32582	143176	46510276
Stomatitis	36.44	15.37	3	32607	68294	46585158
Electroencephalogram abnormal	36.28	15.37	26	32584	3728	46649724
Pulse absent	36.11	15.37	29	32581	4927	46648525
Oedema peripheral	36.07	15.37	35	32575	159671	46493781
Musculoskeletal stiffness	35.60	15.37	12	32598	97981	46555471
Left ventricle outflow tract obstruction	35.56	15.37	11	32599	221	46653231
Posterior reversible encephalopathy syndrome	35.20	15.37	48	32562	15093	46638359
Angioedema	35.17	15.37	82	32528	39260	46614192
Perforation	35.01	15.37	16	32594	971	46652481
Wrong product administered	34.90	15.37	30	32580	5600	46647852
Subcutaneous emphysema	34.43	15.37	15	32595	812	46652640
Left ventricular dysfunction	34.27	15.37	39	32571	10216	46643236
Malignant neoplasm progression	34.23	15.37	3	32607	64923	46588529
Hypocapnia	34.22	15.37	12	32598	361	46653091
Infusion related reaction	34.07	15.37	14	32596	101194	46552258
Paralysis	34.06	15.37	36	32574	8685	46644767
Hepatocellular injury	33.79	15.37	68	32542	29454	46623998
Hypercapnia	33.56	15.37	27	32583	4599	46648853
Disease progression	33.48	15.37	11	32599	91289	46562163
Muscle twitching	33.34	15.37	46	32564	14626	46638826
Renal injury	33.10	15.37	37	32573	9504	46643948
Cardiac output decreased	33.03	15.37	15	32595	897	46652555
Myxoedema coma	32.97	15.37	12	32598	403	46653049
Airway peak pressure increased	32.92	15.37	11	32599	285	46653167
Unmasking of previously unidentified disease	32.87	15.37	14	32596	717	46652735
Blood lactic acid increased	32.77	15.37	29	32581	5628	46647824
Dehydration	32.64	15.37	38	32572	159502	46493950
Delirium	32.63	15.37	77	32533	37151	46616301
Skin test positive	32.56	15.37	14	32596	734	46652718
Muscle relaxant therapy	32.53	15.37	9	32601	120	46653332
Hepatitis	31.98	15.37	70	32540	32145	46621307
Inappropriate schedule of product administration	31.72	15.37	4	32606	65009	46588443
Coma scale abnormal	31.69	15.37	27	32583	4979	46648473
Maternal exposure during delivery	31.39	15.37	14	32596	802	46652650
Procedural haemorrhage	31.37	15.37	20	32590	2366	46651086
Herpes zoster	31.19	15.37	5	32605	67867	46585585
Feeling abnormal	31.14	15.37	25	32585	125035	46528417
Extravasation	31.01	15.37	19	32591	2096	46651356
Injection site erythema	30.98	15.37	7	32603	74420	46579032
Swelling	30.86	15.37	25	32585	124486	46528966
Myoglobinuria	30.85	15.37	10	32600	235	46653217
Oropharyngeal pain	30.83	15.37	7	32603	74161	46579291
Altered state of consciousness	30.66	15.37	57	32553	23291	46630161
Procedural vomiting	30.63	15.37	12	32598	495	46652957
Arrhythmia	30.47	15.37	72	32538	34769	46618683
Premature delivery	30.40	15.37	55	32555	22014	46631438
Depression	30.21	15.37	45	32565	170059	46483393
Lipoedema	30.18	15.37	9	32601	159	46653293
Recurrence of neuromuscular blockade	29.76	15.37	8	32602	95	46653357
Systemic lupus erythematosus	29.51	15.37	5	32605	65175	46588277
Haemodilution	29.46	15.37	8	32602	99	46653353
Somatosensory evoked potentials abnormal	28.99	15.37	5	32605	3	46653449
Renal failure	28.90	15.37	156	32454	113438	46540014
Blood pressure immeasurable	28.80	15.37	15	32595	1212	46652240
Coma	28.79	15.37	98	32512	58251	46595201
Hypovolaemia	28.72	15.37	35	32575	9853	46643599
Neuroleptic malignant syndrome	28.53	15.37	37	32573	11085	46642367
Acute postoperative sialadenitis	28.38	15.37	6	32604	22	46653430
Ventricular dysfunction	28.26	15.37	20	32590	2812	46650640
Vitamin K deficiency	28.10	15.37	11	32599	453	46652999
Aspartate aminotransferase increased	27.94	15.37	119	32491	78581	46574871
Abdominal pain	27.89	15.37	76	32534	229955	46423497
Lower respiratory tract infection	27.84	15.37	3	32607	55086	46598366
Procedural hypertension	27.84	15.37	10	32600	323	46653129
Dry mouth	27.74	15.37	3	32607	54923	46598529
Atrioventricular dissociation	27.59	15.37	9	32601	216	46653236
Cyanosis	27.55	15.37	44	32566	15927	46637525
Pupils unequal	27.51	15.37	15	32595	1329	46652123
Asthma	27.23	15.37	15	32595	91527	46561925
Abdominal pain upper	27.22	15.37	37	32573	145268	46508184
Atrioventricular block second degree	27.19	15.37	22	32588	3777	46649675
Anaemia	27.07	15.37	90	32520	255689	46397763
Hypoaesthesia	26.89	15.37	26	32584	118843	46534609
Hypertriglyceridaemia	26.76	15.37	26	32584	5678	46647774
Myoglobin urine present	26.53	15.37	7	32603	77	46653375
Myotonia	26.38	15.37	8	32602	150	46653302
Acute kidney injury	26.34	15.37	266	32344	235589	46417863
Toxic epidermal necrolysis	26.32	15.37	52	32558	22226	46631226
Ultrasound ovary abnormal	26.29	15.37	7	32603	80	46653372
Thyrotoxic crisis	26.18	15.37	12	32598	733	46652719
Syncope	26.02	15.37	21	32589	104782	46548670
Electrocardiogram QT prolonged	26.02	15.37	87	32523	51238	46602214
Oesophageal intramural haematoma	25.98	15.37	7	32603	84	46653368
Hepatic failure	25.97	15.37	66	32544	33350	46620102
Anhedonia	25.92	15.37	34	32576	10301	46643151
Irregular breathing	25.79	15.37	9	32601	267	46653185
Gastrooesophageal reflux disease	25.48	15.37	10	32600	74334	46579118
Contraindicated product administered	25.42	15.37	12	32598	79935	46573517
Hypotensive transfusion reaction	25.28	15.37	6	32604	41	46653411
Gaze palsy	25.23	15.37	14	32596	1284	46652168
Sinus bradycardia	25.20	15.37	39	32571	13743	46639709
Patent ductus arteriosus	24.80	15.37	21	32589	3841	46649611
Bezold-Jarisch reflex	24.67	15.37	5	32605	14	46653438
Intensive care unit acquired weakness	24.67	15.37	11	32599	630	46652822
Diabetes mellitus	24.62	15.37	3	32607	50062	46603390
Hyperammonaemic encephalopathy	24.55	15.37	16	32594	1966	46651486
Coronary artery embolism	24.44	15.37	8	32602	194	46653258
Depressed level of consciousness	24.44	15.37	81	32529	47488	46605964
Post procedural haemorrhage	24.40	15.37	28	32582	7398	46646054
Anaesthetic complication cardiac	24.17	15.37	5	32605	16	46653436
Gastrointestinal disorder	24.01	15.37	6	32604	59570	46593882
Tracheal injury	23.83	15.37	6	32604	54	46653398
Chest discomfort	23.80	15.37	17	32593	90252	46563200
White blood cell count decreased	23.74	15.37	26	32584	112205	46541247
Alanine aminotransferase increased	23.53	15.37	123	32487	88328	46565124
Kounis syndrome	23.46	15.37	13	32597	1189	46652263
Muscle spasms	23.41	15.37	31	32579	123082	46530370
Suspected product contamination	23.11	15.37	5	32605	21	46653431
Skin test negative	23.11	15.37	5	32605	21	46653431
Macroglossia	22.98	15.37	10	32600	540	46652912
Electrocardiogram repolarisation abnormality	22.84	15.37	13	32597	1252	46652200
Trigemino-cardiac reflex	22.83	15.37	4	32606	3	46653449
Air embolism	22.74	15.37	8	32602	243	46653209
Hospitalisation	22.61	15.37	8	32602	63377	46590075
Abscess neck	22.55	15.37	10	32600	565	46652887
Post procedural fever	22.47	15.37	8	32602	252	46653200
Systemic inflammatory response syndrome	22.46	15.37	23	32587	5348	46648104
Vision blurred	22.38	15.37	14	32596	79694	46573758
Foetal exposure during pregnancy	22.12	15.37	59	32551	30688	46622764
Obstructive airways disorder	21.84	15.37	36	32574	13376	46640076
Urticaria	21.77	15.37	149	32461	117743	46535709
Atrioventricular block first degree	21.48	15.37	24	32586	6162	46647290
Neck pain	21.47	15.37	6	32604	55300	46598152
Tachypnoea	21.35	15.37	37	32573	14314	46639138
Palpitations	21.35	15.37	21	32589	95238	46558214
Nasal congestion	21.11	15.37	4	32606	48109	46605343
Cough	21.08	15.37	86	32524	230163	46423289
Premature baby	21.06	15.37	42	32568	18070	46635382
Upper respiratory tract infection	21.05	15.37	9	32601	63547	46589905
Chronic obstructive pulmonary disease	21.03	15.37	7	32603	57626	46595826
Endotracheal intubation	20.93	15.37	15	32595	2150	46651302
Burkholderia test positive	20.79	15.37	6	32604	94	46653358
Supraventricular tachycardia	20.78	15.37	35	32575	13235	46640217
Loss of personal independence in daily activities	20.77	15.37	7	32603	57176	46596276
Dyspepsia	20.68	15.37	11	32599	68461	46584991
Extrasystoles	20.64	15.37	21	32589	4848	46648604
Tidal volume decreased	20.49	15.37	5	32605	39	46653413
Intensive care unit delirium	20.38	15.37	5	32605	40	46653412
Tongue oedema	20.20	15.37	19	32591	3987	46649465
Musculoskeletal pain	20.13	15.37	12	32598	70116	46583336
Medication error	19.94	15.37	57	32553	30854	46622598
Drug use disorder	19.92	15.37	16	32594	2719	46650733
Epistaxis	19.91	15.37	10	32600	64295	46589157
Eosinophilic pneumonia acute	19.83	15.37	8	32602	357	46653095
Respiratory distress	19.77	15.37	58	32552	31858	46621594
Device programming error	19.76	15.37	5	32605	46	46653406
Infantile apnoea	19.69	15.37	10	32600	766	46652686
Cystitis	19.66	15.37	3	32607	42238	46611214
Acidosis	19.57	15.37	31	32579	11143	46642309
Hypovolaemic shock	19.54	15.37	21	32589	5162	46648290
Cardiac massage	19.29	15.37	4	32606	13	46653439
Hypervolaemia	19.15	15.37	13	32597	1709	46651743
Idiosyncratic drug reaction	19.09	15.37	10	32600	817	46652635
Therapeutic product effect incomplete	18.98	15.37	16	32594	78137	46575315
Transcranial electrical motor evoked potential monitoring abnormal	18.80	15.37	3	32607	0	46653452
Bispectral index decreased	18.80	15.37	3	32607	0	46653452
Peripheral nerve palsy	18.64	15.37	4	32606	16	46653436
Extubation	18.64	15.37	4	32606	16	46653436
Administration site extravasation	18.60	15.37	9	32601	621	46652831
Drug-induced liver injury	18.58	15.37	49	32561	25319	46628133
Blood magnesium decreased	18.57	15.37	30	32580	10962	46642490
Lactic acidosis	18.55	15.37	59	32551	33850	46619602
Sepsis syndrome	18.47	15.37	10	32600	874	46652578
Neurological decompensation	18.32	15.37	13	32597	1835	46651617
Long QT syndrome	18.26	15.37	16	32594	3064	46650388
Hypoxic-ischaemic encephalopathy	18.06	15.37	18	32592	4055	46649397
Euthyroid sick syndrome	18.05	15.37	5	32605	67	46653385
Apnoeic attack	17.91	15.37	7	32603	287	46653165
Tracheal haemorrhage	17.90	15.37	6	32604	157	46653295
Uterine atony	17.83	15.37	6	32604	159	46653293
Ischaemic cerebral infarction	17.79	15.37	11	32599	1234	46652218
Mucosal inflammation	17.62	15.37	3	32607	38973	46614479
Hypernatraemia	17.53	15.37	22	32588	6379	46647073
Haematemesis	17.51	15.37	52	32558	28754	46624698
Brain death	17.41	15.37	15	32595	2808	46650644
Systolic dysfunction	17.24	15.37	11	32599	1303	46652149
Balance disorder	17.21	15.37	12	32598	64509	46588943
Face oedema	17.20	15.37	40	32570	19113	46634339
Stevens-Johnson syndrome	17.06	15.37	45	32565	23252	46630200
Haemoperitoneum	16.98	15.37	14	32596	2468	46650984
Procedural dizziness	16.94	15.37	5	32605	85	46653367
Ventricular asystole	16.94	15.37	5	32605	85	46653367
Abdominal sepsis	16.92	15.37	11	32599	1346	46652106
Burning sensation	16.91	15.37	5	32605	44406	46609046
Dry skin	16.78	15.37	4	32606	41012	46612440
Agitation postoperative	16.77	15.37	4	32606	28	46653424
Nerve stimulation test abnormal	16.73	15.37	3	32607	3	46653449
Partial seizures	16.65	15.37	19	32591	4991	46648461
Bone pain	16.58	15.37	6	32604	46884	46606568
Fat embolism	16.44	15.37	6	32604	203	46653249
Acute chest syndrome	16.40	15.37	8	32602	562	46652890
Infection	16.27	15.37	44	32566	133548	46519904
Bradycardia foetal	16.24	15.37	7	32603	369	46653083
Encephalitis autoimmune	16.23	15.37	10	32600	1114	46652338
Migraine	16.20	15.37	15	32595	70011	46583441
Chemical peritonitis	16.18	15.37	5	32605	100	46653352
Hepatitis C	16.18	15.37	21	32589	6297	46647155
Respiratory rate decreased	16.16	15.37	15	32595	3095	46650357
Spinal cord disorder	16.15	15.37	10	32600	1124	46652328
Suicidal ideation	15.69	15.37	10	32600	56372	46597080
Emotional distress	15.51	15.37	52	32558	30655	46622797
Polyuria	15.51	15.37	22	32588	7173	46646279
Myalgia	15.40	15.37	40	32570	123048	46530404
Rhinorrhoea	15.39	15.37	7	32603	47658	46605794

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Anaphylactic shock	1421.32	15.78	535	30087	13458	29908398
Propofol infusion syndrome	1072.81	15.78	234	30388	632	29921224
Anaphylactic reaction	680.70	15.78	398	30224	27584	29894272
Hyperthermia malignant	509.54	15.78	150	30472	1684	29920172
Hypotension	439.17	15.78	755	29867	199810	29722046
Cardiac arrest	406.78	15.78	487	30135	92363	29829493
Bronchospasm	367.13	15.78	189	30433	10149	29911707
Bradycardia	318.84	15.78	363	30259	65163	29856693
Delayed recovery from anaesthesia	306.34	15.78	82	30540	629	29921227
Rhabdomyolysis	290.45	15.78	341	30281	63239	29858617
Serotonin syndrome	268.81	15.78	188	30434	17703	29904153
Anaesthetic complication	222.35	15.78	70	30552	999	29920857
Fatigue	215.95	15.78	35	30587	320638	29601218
Tachycardia	214.64	15.78	317	30305	73422	29848434
Metabolic acidosis	189.56	15.78	212	30410	37249	29884607
Circulatory collapse	176.26	15.78	154	30468	20060	29901796
Ventricular fibrillation	156.00	15.78	127	30495	15011	29906845
Oxygen saturation decreased	148.80	15.78	202	30420	43238	29878618
Neuromuscular block prolonged	142.30	15.78	39	30583	330	29921526
Pulseless electrical activity	142.26	15.78	85	30537	6102	29915754
Blood pressure decreased	131.97	15.78	199	30423	46876	29874980
Diarrhoea	131.24	15.78	91	30531	334012	29587844
Status epilepticus	129.31	15.78	100	30522	10972	29910884
Electrocardiogram ST segment elevation	128.83	15.78	71	30551	4371	29917485
Haemodynamic instability	122.13	15.78	85	30537	7930	29913926
Shock	121.84	15.78	133	30489	22726	29899130
Respiratory depression	113.26	15.78	94	30528	11409	29910447
Fall	107.25	15.78	27	30595	181845	29740011
Death	107.18	15.78	125	30497	357158	29564698
Intensive care unit acquired weakness	101.77	15.78	37	30585	835	29921021
Airway complication of anaesthesia	99.77	15.78	24	30598	112	29921744
Ventricular tachycardia	98.93	15.78	122	30500	23740	29898116
Post procedural complication	95.54	15.78	86	30536	11640	29910216
Arthralgia	92.96	15.78	14	30608	135777	29786079
Decreased appetite	90.81	15.78	21	30601	149889	29771967
Laryngospasm	89.58	15.78	38	30584	1305	29920551
Hypoxia	88.42	15.78	168	30454	47686	29874170
Hypoxic-ischaemic encephalopathy	86.51	15.78	56	30566	4631	29917225
Blood creatine phosphokinase increased	86.08	15.78	158	30464	43690	29878166
Multiple organ dysfunction syndrome	85.80	15.78	196	30426	63291	29858565
Drug interaction	84.42	15.78	415	30207	199153	29722703
Negative pressure pulmonary oedema	83.46	15.78	23	30599	199	29921657
Dizziness	81.90	15.78	49	30573	194860	29726996
Anaphylactoid shock	81.25	15.78	26	30596	392	29921464
Procedural complication	78.77	15.78	52	30570	4445	29917411
Anaesthetic complication neurological	74.11	15.78	23	30599	312	29921544
Fear	73.96	15.78	72	30550	10753	29911103
Arteriospasm coronary	73.59	15.78	41	30581	2577	29919279
Respiratory acidosis	72.18	15.78	48	30574	4154	29917702
Stress cardiomyopathy	71.87	15.78	34	30588	1515	29920341
Injury	71.25	15.78	99	30523	21632	29900224
Hypertriglyceridaemia	71.16	15.78	62	30560	8036	29913820
Diabetes insipidus	71.07	15.78	38	30584	2201	29919655
Apnoea	69.76	15.78	55	30567	6203	29915653
Headache	69.59	15.78	51	30571	182255	29739601
Vasoplegia syndrome	68.65	15.78	31	30591	1240	29920616
Procedural hypotension	68.36	15.78	29	30593	996	29920860
Trigemino-cardiac reflex	66.96	15.78	17	30605	103	29921753
Product dose omission issue	66.12	15.78	8	30614	91623	29830233
Transmission of an infectious agent via product	65.91	15.78	18	30604	150	29921706
Malaise	63.33	15.78	47	30575	166915	29754941
Myoclonus	63.28	15.78	73	30549	13239	29908617
Pulse absent	62.95	15.78	49	30573	5424	29916432
Seizure like phenomena	62.93	15.78	23	30599	527	29921329
Cyanosis	62.80	15.78	69	30553	11866	29909990
Asthenia	62.39	15.78	81	30541	221209	29700647
Brain oedema	62.35	15.78	70	30552	12328	29909528
Renal injury	62.05	15.78	68	30554	11661	29910195
Pain in extremity	61.82	15.78	18	30604	110203	29811653
Drug level changed	60.83	15.78	20	30602	330	29921526
Agitation	60.25	15.78	155	30467	53918	29867938
Tachypnoea	59.64	15.78	75	30547	14877	29906979
Ventricular arrhythmia	57.32	15.78	42	30580	4246	29917610
Anaemia	56.71	15.78	78	30544	207914	29713942
Erythema	56.57	15.78	191	30431	77260	29844596
Nausea	56.45	15.78	139	30483	296818	29625038
Dystonia	56.04	15.78	59	30563	9668	29912188
Kounis syndrome	54.81	15.78	29	30593	1644	29920212
Post procedural fever	54.70	15.78	16	30606	175	29921681
Anhedonia	54.08	15.78	54	30568	8315	29913541
Muscle rigidity	53.43	15.78	59	30563	10202	29911654
Intestinal ischaemia	53.07	15.78	49	30573	6848	29915008
Hypoventilation	53.05	15.78	35	30587	2988	29918868
Autonomic nervous system imbalance	52.39	15.78	32	30590	2389	29919467
Tryptase increased	52.04	15.78	16	30606	210	29921646
Toxic epidermal necrolysis	51.87	15.78	77	30545	17863	29903993
Weight decreased	51.61	15.78	47	30575	150874	29770982
Dyspnoea	49.59	15.78	175	30447	333120	29588736
Blood lactic acid increased	47.95	15.78	43	30579	5787	29916069
Peripheral swelling	47.50	15.78	4	30618	61070	29860786
Respiratory failure	47.29	15.78	216	30406	100426	29821430
Necrosis ischaemic	47.07	15.78	15	30607	223	29921633
Abdominal pain	46.67	15.78	42	30580	135612	29786244
Acute respiratory distress syndrome	46.56	15.78	85	30537	23387	29898469
Cardio-respiratory arrest	46.02	15.78	146	30476	57160	29864696
Sinus arrest	46.01	15.78	25	30597	1495	29920361
Respiratory arrest	45.93	15.78	96	30526	29162	29892694
Endotracheal intubation complication	45.48	15.78	16	30606	327	29921529
Product contamination	45.41	15.78	19	30603	630	29921226
Dehydration	45.25	15.78	36	30586	123503	29798353
Neuropathy peripheral	44.39	15.78	9	30613	70466	29851390
Weight increased	44.31	15.78	11	30611	74902	29846954
Blood pressure measurement	44.21	15.78	13	30609	145	29921711
Sinus tachycardia	44.04	15.78	66	30556	15438	29906418
Hepatorenal failure	43.33	15.78	18	30604	586	29921270
Acidosis	43.21	15.78	53	30569	10248	29911608
Disease progression	43.05	15.78	14	30608	79860	29841996
Oxygen saturation immeasurable	42.05	15.78	10	30612	44	29921812
Malignant neoplasm progression	42.01	15.78	11	30611	72276	29849580
Type I hypersensitivity	41.52	15.78	20	30602	928	29920928
Constipation	41.22	15.78	33	30589	112873	29808983
Anticholinergic syndrome	41.05	15.78	19	30603	805	29921051
Anaesthetic complication cardiac	41.05	15.78	9	30613	25	29921831
Gait disturbance	40.48	15.78	13	30609	74764	29847092
Febrile neutropenia	40.45	15.78	30	30592	106663	29815193
Anaphylactoid reaction	40.05	15.78	26	30596	2160	29919696
Brugada syndrome	39.87	15.78	17	30605	591	29921265
Opisthotonus	39.52	15.78	15	30607	383	29921473
Pneumonia	39.43	15.78	192	30430	334114	29587742
Feeling abnormal	38.45	15.78	6	30616	56750	29865106
Neonatal respiratory depression	38.29	15.78	15	30607	418	29921438
Hyperammonaemia	38.24	15.78	37	30585	5483	29916373
Coma blister	38.15	15.78	10	30612	70	29921786
Pulmonary alveolar haemorrhage	38.05	15.78	40	30582	6541	29915315
Plasma cell myeloma	37.74	15.78	5	30617	53457	29868399
Airway peak pressure increased	37.68	15.78	8	30614	18	29921838
Hypotonic-hyporesponsive episode	37.68	15.78	8	30614	18	29921838
Emotional distress	37.68	15.78	62	30560	15703	29906153
Intracranial pressure increased	37.46	15.78	30	30592	3460	29918396
Hypercapnia	37.11	15.78	31	30591	3793	29918063
Insomnia	37.02	15.78	25	30597	93311	29828545
Superinfection	36.64	15.78	22	30600	1592	29920264
Pulmonary oedema	36.18	15.78	113	30509	43862	29877994
Oedema peripheral	36.10	15.78	33	30589	105799	29816057
Neuromuscular blockade	35.73	15.78	11	30611	145	29921711
Haemodialysis	35.62	15.78	50	30572	11023	29910833
Mean arterial pressure decreased	35.53	15.78	11	30611	148	29921708
White blood cell count decreased	35.33	15.78	21	30601	83926	29837930
Cough	35.32	15.78	46	30576	125596	29796260
Post procedural haemorrhage	35.30	15.78	42	30580	7868	29913988
Back pain	34.99	15.78	32	30590	102564	29819292
Urticaria	34.96	15.78	129	30493	54477	29867379
Areflexia	34.92	15.78	26	30596	2693	29919163
Urinary tract infection	34.58	15.78	16	30606	73643	29848213
Oculocardiac reflex	34.46	15.78	9	30613	62	29921794
Brain injury	34.38	15.78	35	30587	5513	29916343
Cardiac failure congestive	34.29	15.78	22	30600	84385	29837471
Neutropenia	34.19	15.78	49	30573	128491	29793365
Neuroleptic malignant syndrome	33.57	15.78	60	30562	16235	29905621
Therapeutic product effect prolonged	32.87	15.78	12	30610	274	29921582
Postoperative delirium	32.48	15.78	8	30614	42	29921814
Product contamination microbial	32.16	15.78	15	30607	647	29921209
Pancytopenia	32.12	15.78	24	30598	85028	29836828
Procedural haemorrhage	31.47	15.78	23	30599	2315	29919541
Dyskinesia	31.23	15.78	69	30553	21765	29900091
Resuscitation	31.14	15.78	18	30604	1214	29920642
Vomiting	30.90	15.78	118	30504	219700	29702156
Drug use disorder	30.84	15.78	26	30596	3222	29918634
Influenza	30.77	15.78	4	30618	43394	29878462
Delirium	30.33	15.78	101	30521	40530	29881326
Electrocardiogram QT prolonged	30.32	15.78	93	30529	35742	29886114
PCO2 increased	29.75	15.78	14	30608	616	29921240
Electrocardiogram ST-T segment elevation	29.43	15.78	5	30617	0	29921856
Spinal muscular atrophy	29.40	15.78	10	30612	184	29921672
Lactic acidosis	29.26	15.78	84	30538	31129	29890727
Chest pain	29.19	15.78	47	30575	117580	29804276
Acidosis hyperchloraemic	29.05	15.78	11	30611	279	29921577
Nodal rhythm	28.74	15.78	18	30604	1405	29920451
Electrocardiogram T wave inversion	28.57	15.78	21	30601	2133	29919723
Paraesthesia	28.43	15.78	10	30612	54317	29867539
Mucosal ulceration	28.14	15.78	15	30607	863	29920993
Chills	28.03	15.78	147	30475	72191	29849665
Pneumomediastinum	27.29	15.78	19	30603	1772	29920084
Myoglobin blood increased	27.27	15.78	19	30603	1774	29920082
Chromaturia	27.22	15.78	50	30572	13815	29908041
Torsade de pointes	26.98	15.78	35	30587	7155	29914701
Atrioventricular block complete	26.85	15.78	38	30584	8439	29913417
Local anaesthetic systemic toxicity	26.54	15.78	9	30613	164	29921692
Suicidal ideation	26.41	15.78	3	30619	36111	29885745
Subcutaneous emphysema	26.36	15.78	15	30607	982	29920874
Locked-in syndrome	26.25	15.78	10	30612	258	29921598
Muscle spasms	26.19	15.78	17	30605	64821	29857035
Syncope	26.06	15.78	29	30593	84874	29836982
Cellulitis	25.55	15.78	8	30614	46776	29875080
Pseudocholinesterase deficiency	25.49	15.78	6	30616	25	29921831
Suspected product contamination	25.15	15.78	7	30615	63	29921793
Disseminated intravascular coagulation	25.13	15.78	64	30558	22107	29899749
Systemic inflammatory response syndrome	24.78	15.78	32	30590	6514	29915342
Trismus	24.68	15.78	20	30602	2345	29919511
Unevaluable event	24.61	15.78	80	30542	31705	29890151
Electrocardiogram abnormal	24.20	15.78	30	30592	5862	29915994
Spinal cord infarction	24.12	15.78	9	30613	219	29921637
Generalised tonic-clonic seizure	23.80	15.78	58	30564	19493	29902363
Unresponsive to stimuli	23.70	15.78	70	30552	26349	29895507
Brain death	23.67	15.78	20	30602	2486	29919370
Obstructive airways disorder	23.52	15.78	37	30585	9022	29912834
Pruritus	23.42	15.78	54	30568	118150	29803706
Ventricular extrasystoles	23.32	15.78	42	30580	11432	29910424
Hypotonia	23.28	15.78	32	30590	6916	29914940
Sedation complication	23.27	15.78	13	30609	821	29921035
Heparin-induced thrombocytopenia	23.06	15.78	28	30594	5355	29916501
Coronary artery disease	23.01	15.78	11	30611	49701	29872155
Conversion disorder	23.00	15.78	10	30612	365	29921491
Stomatitis	22.98	15.78	5	30617	37274	29884582
Hepatitis fulminant	22.86	15.78	24	30598	3917	29917939
Long QT syndrome	22.82	15.78	19	30603	2314	29919542
Oropharyngeal discomfort	22.80	15.78	16	30606	1511	29920345
Unwanted awareness during anaesthesia	22.76	15.78	6	30616	43	29921813
Weight bearing difficulty	22.69	15.78	13	30609	862	29920994
Nystagmus	22.68	15.78	25	30597	4313	29917543
Suspected product quality issue	22.63	15.78	8	30614	166	29921690
Post-injection delirium sedation syndrome	22.55	15.78	10	30612	383	29921473
Blood catecholamines increased	22.28	15.78	5	30617	16	29921840
Hyperventilation	22.02	15.78	19	30603	2430	29919426
Periorbital swelling	21.70	15.78	8	30614	188	29921668
Neuromyopathy	21.42	15.78	13	30609	959	29920897
Myocardial infarction	21.35	15.78	62	30560	125563	29796293
Acute pulmonary oedema	21.35	15.78	32	30590	7483	29914373
Inappropriate schedule of product administration	21.33	15.78	7	30615	39721	29882135
Recurrence of neuromuscular blockade	21.15	15.78	7	30615	118	29921738
Drug intolerance	21.00	15.78	10	30612	45281	29876575
Air embolism	20.88	15.78	7	30615	123	29921733
Seizure	20.88	15.78	172	30450	98303	29823553
Priapism	20.86	15.78	25	30597	4718	29917138
Bronchitis	20.82	15.78	7	30615	39118	29882738
Dialysis	20.77	15.78	39	30583	10957	29910899
Depression	20.72	15.78	38	30584	90399	29831457
Hypothermia	20.70	15.78	36	30586	9531	29912325
Migraine with aura	20.60	15.78	10	30612	472	29921384
Renal impairment	20.59	15.78	152	30470	84032	29837824
Electrocardiogram ST segment depression	20.58	15.78	18	30604	2344	29919512
Neutrophil count decreased	20.26	15.78	9	30613	42445	29879411
Chronic obstructive pulmonary disease	20.17	15.78	11	30611	46115	29875741
Mydriasis	20.14	15.78	28	30594	6115	29915741
Continuous haemodiafiltration	19.93	15.78	13	30609	1088	29920768
Premature recovery from anaesthesia	19.89	15.78	4	30618	6	29921850
Clonus	19.81	15.78	18	30604	2463	29919393
Diabetes mellitus	19.79	15.78	9	30613	41856	29880000
Contusion	19.68	15.78	4	30618	31276	29890580
Incorrect drug administration rate	19.56	15.78	13	30609	1123	29920733
Depressed level of consciousness	19.39	15.78	84	30538	38138	29883718
Musculoskeletal pain	19.37	15.78	4	30618	30936	29890920
Capillary nail refill test abnormal	19.20	15.78	5	30617	34	29921822
End-tidal CO2 increased	19.16	15.78	4	30618	8	29921848
Respiratory tract infection bacterial	19.16	15.78	10	30612	551	29921305
Laryngeal oedema	18.90	15.78	20	30602	3294	29918562
Haemoglobin decreased	18.89	15.78	57	30565	114041	29807815
Treatment failure	18.81	15.78	6	30616	34673	29887183
Acute kidney injury	18.78	15.78	388	30234	273454	29648402
Epistaxis	18.68	15.78	16	30606	52965	29868891
Stress	18.52	15.78	54	30568	20181	29901675
Abdominal pain upper	18.50	15.78	22	30600	62529	29859327
Hypoglycaemia	18.46	15.78	15	30607	50966	29870890
Systolic anterior motion of mitral valve	18.38	15.78	5	30617	41	29921815
Hypocapnia	18.19	15.78	6	30616	100	29921756
Pupil fixed	18.08	15.78	15	30607	1817	29920039
Transcranial electrical motor evoked potential monitoring abnormal	18.01	15.78	4	30618	12	29921844
Septic shock	17.99	15.78	119	30503	63488	29858368
Palpitations	17.87	15.78	6	30616	33567	29888289
Skin test negative	17.77	15.78	5	30617	47	29921809
Hyperkalaemia	17.77	15.78	122	30500	65888	29855968
Pulmonary embolism	17.74	15.78	33	30589	78102	29843754
Dyspnoea exertional	17.73	15.78	7	30615	35423	29886433
Fear of death	17.66	15.78	10	30612	648	29921208
Therapeutic response prolonged	17.66	15.78	3	30619	0	29921856
Light anaesthesia	17.66	15.78	3	30619	0	29921856
Coma	17.63	15.78	85	30537	40364	29881492
Congenital megaureter	17.61	15.78	6	30616	111	29921745
Coagulopathy	17.56	15.78	50	30572	18437	29903419
Respiratory alkalosis	17.17	15.78	13	30609	1381	29920475
Blood pressure systolic decreased	17.06	15.78	20	30602	3687	29918169
Hepatitis	17.06	15.78	56	30566	22300	29899556
Renal failure	16.97	15.78	204	30418	128762	29793094
Thyrotoxic crisis	16.83	15.78	8	30614	360	29921496
Herpes zoster	16.56	15.78	5	30617	29938	29891918
General physical health deterioration	16.49	15.78	50	30572	99894	29821962
Cardiogenic shock	16.40	15.78	46	30576	16815	29905041
Anaesthetic complication pulmonary	16.40	15.78	4	30618	20	29921836
Electrocardiogram QRS complex prolonged	16.33	15.78	21	30601	4256	29917600
Hypertransaminasaemia	16.31	15.78	20	30602	3865	29917991
Upper airway obstruction	16.19	15.78	9	30613	563	29921293
Myoglobinuria	16.04	15.78	10	30612	774	29921082
Dysgeusia	15.96	15.78	3	30619	24798	29897058
Periventricular haemorrhage neonatal	15.79	15.78	4	30618	24	29921832
Hepatitis acute	15.78	15.78	27	30595	7056	29914800

Pharmacologic Action:

Source	Code	Description
ATC	N01AX10	NERVOUS SYSTEM ANESTHETICS ANESTHETICS, GENERAL Other general anesthetics
FDA EPC	N0000175681	General Anesthetic
MeSH PA	D000777	Anesthetics
MeSH PA	D018686	Anesthetics, Intravenous
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D006993	Hypnotics and Sedatives
FDA PE	N0000175975	General Anesthesia
CHEBI has role	CHEBI:35623	antiepileptic
CHEBI has role	CHEBI:35717	sedatives
CHEBI has role	CHEBI:38877	intravenous anesthetics
CHEBI has role	CHEBI:48578	free-radical scavenger
CHEBI has role	CHEBI:50919	antiemetico

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
General anesthesia	indication	50697003
Sedation in Intubated Patients	indication
Sedation as Adjunct to Anesthesia	indication
Apnea	contraindication	1023001
Asthenia	contraindication	13791008
Hypovolemia	contraindication	28560003
Low blood pressure	contraindication	45007003
Cerebral arteriosclerosis	contraindication	65312002
Decreased respiratory function	contraindication	80954004
Epilepsy	contraindication	84757009	DOID:1826
Myocardial dysfunction	contraindication	233928007
Disorder of lipid metabolism	contraindication	267431006
Hypoxia	contraindication	389086002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.8	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
GABA A receptor alpha-2/beta-2/gamma-2	Ion channel	P18507 P47869 P47870	GBRA2_HUMAN GBRB2_HUMAN GBRG2_HUMAN	POSITIVE ALLOSTERIC MODULATOR	EC50	4.95		CHEMBL	CHEMBL
GABA-A receptor alpha-1/beta-3/gamma-2	Ion channel	P14867 P18507 P28472	GBRA1_HUMAN GBRB3_HUMAN GBRG2_HUMAN	POSITIVE ALLOSTERIC MODULATOR	EC50	5.39		CHEMBL	CHEMBL
GABA-A receptor alpha-1/beta-2/gamma-2	Ion channel	P14867 P18507 P47870	GBRA1_HUMAN GBRB2_HUMAN GBRG2_HUMAN	POSITIVE ALLOSTERIC MODULATOR	EC50	5.70		CHEMBL	CHEMBL
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	5.22		DRUG MATRIX
Cytochrome P450 2C9	Enzyme	P11712	CP2C9_HUMAN		IC50	4.91		WOMBAT-PK
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN		IC50	4.71		WOMBAT-PK
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN		IC50	4.01		WOMBAT-PK
Fatty-acid amide hydrolase 1	Enzyme	O00519	FAAH1_HUMAN		IC50	4.28		WOMBAT-PK
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN		IC50	5.42		DRUG MATRIX
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	5.03		DRUG MATRIX
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	5.46		DRUG MATRIX
Arachidonate 15-lipoxygenase	Enzyme		LOX15_RABIT		IC50	5.12		DRUG MATRIX
Fatty-acid amide hydrolase 1	Enzyme		FAAH1_RAT		IC50	4.85		CHEMBL
GABA-A receptor; anion channel	Ion channel		GBRA1_RAT GBRA2_RAT GBRA3_RAT GBRA4_RAT GBRA5_RAT GBRA6_RAT GBRB1_RAT GBRB2_RAT GBRB3_RAT GBRD_RAT GBRE_RAT GBRG1_RAT GBRG2_RAT GBRG3_RAT GBRP_RAT Q91ZM7_RAT		IC50	5.40		CHEMBL
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	Ion channel		HCN1_MOUSE	BLOCKER	IC50	5.20		IUPHAR

External reference:

ID	Source
4019500	VUID
N0000147620	NUI
D00549	KEGG_DRUG
4019500	VANDF
C0678120	UMLSCUI
CHEBI:44915	CHEBI
PFL	PDB_CHEM_ID
CHEMBL526	ChEMBL_ID
4943	PUBCHEM_CID
D015742	MESH_DESCRIPTOR_UI
DB00818	DRUGBANK_ID
5464	IUPHAR_LIGAND_ID
5073	INN_ID
YI7VU623SF	UNII
196459	RXNORM
14179	MMSL
5372	MMSL
65	MMSL
d00933	MMSL
003528	NDDF
387423006	SNOMEDCT_US
74674007	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0209	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	26 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0234	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	26 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0248	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	26 sections
Propofol Lipuro	HUMAN PRESCRIPTION DRUG LABEL	1	0264-4850	INJECTION, EMULSION	10 mg	INTRAVENOUS	unapproved drug other	3 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	0409-4699	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	26 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0591-2136	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	26 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6194	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	24 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6195	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	24 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6196	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	24 sections
Fresenius Propoven 2%	HUMAN PRESCRIPTION DRUG LABEL	1	18124-027	EMULSION	20 mg	INTRAVENOUS	unapproved drug other	2 sections
propofol	HUMAN PRESCRIPTION DRUG LABEL	1	25021-608	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	27 sections
Propofol Injectable Emulsion	HUMAN PRESCRIPTION DRUG LABEL	1	43598-265	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	22 sections
Propofol Injectable Emulsion	HUMAN PRESCRIPTION DRUG LABEL	1	43598-548	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	22 sections
Propofol Injectable Emulsion	HUMAN PRESCRIPTION DRUG LABEL	1	43598-549	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	22 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	50090-4569	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	27 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1293	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	14 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1470	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	14 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1471	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	14 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	52584-098	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	14 sections
Diprivan	HUMAN PRESCRIPTION DRUG LABEL	1	52584-269	INJECTION, EMULSION	10 mg	INTRAVENOUS	NDA	12 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	52584-699	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	14 sections
Diprivan	Human Prescription Drug Label	1	63323-269	INJECTION, EMULSION	10 mg	INTRAVENOUS	NDA	14 sections
Diprivan	Human Prescription Drug Label	1	63323-269	INJECTION, EMULSION	10 mg	INTRAVENOUS	NDA	14 sections
Diprivan	Human Prescription Drug Label	1	63323-269	INJECTION, EMULSION	10 mg	INTRAVENOUS	NDA	14 sections
Diprivan	Human Prescription Drug Label	1	63323-269	INJECTION, EMULSION	10 mg	INTRAVENOUS	NDA	14 sections
Fresenius Propoven 2%	HUMAN PRESCRIPTION DRUG LABEL	1	65219-427	EMULSION	20 mg	INTRAVENOUS	unapproved drug other	2 sections
Diprivan	Human Prescription Drug Label	1	65219-800	INJECTION, EMULSION	10 mg	INTRAVENOUS	NDA	14 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	72572-583	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	24 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	72572-584	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	24 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	72572-585	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	24 sections