propofol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2302 2078-54-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • propofol
  • ampofol
  • diprivan
  • disoprofol
  • pofol
An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
  • Molecular weight: 178.28
  • Formula: C12H18O
  • CLOGP: 3.93
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -3.05
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.16 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 14.02 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 4.70 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 36 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.20 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 2, 1989 FDA FRESENIUS KABI USA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic shock 2122.65 15.37 718 31892 19556 46633896
Anaphylactic reaction 898.94 15.37 522 32088 52590 46600862
Bronchospasm 681.67 15.37 293 32317 15414 46638038
Hypotension 648.95 15.37 803 31807 231786 46421666
Propofol infusion syndrome 643.07 15.37 141 32469 640 46652812
Cardiac arrest 575.84 15.37 488 32122 89911 46563541
Delayed recovery from anaesthesia 346.49 15.37 87 32523 774 46652678
Circulatory collapse 334.89 15.37 201 32409 21423 46632029
Tachycardia 334.46 15.37 379 32231 99243 46554209
Status epilepticus 320.15 15.37 168 32442 13811 46639641
Serotonin syndrome 299.11 15.37 195 32415 24025 46629427
Hyperthermia malignant 283.17 15.37 72 32538 677 46652775
Bradycardia 276.43 15.37 283 32327 66015 46587437
Respiratory depression 273.02 15.37 142 32468 11458 46641994
Stress cardiomyopathy 238.52 15.37 114 32496 7670 46645782
Fatigue 211.70 15.37 81 32529 608616 46044836
Neuromuscular block prolonged 208.94 15.37 53 32557 493 46652959
Multiple organ dysfunction syndrome 199.78 15.37 212 32398 51498 46601954
Oxygen saturation decreased 190.38 15.37 238 32372 68926 46584526
Ventricular tachycardia 188.65 15.37 128 32482 16839 46636613
Shock 188.03 15.37 141 32469 21704 46631748
Drug interaction 186.65 15.37 427 32183 202667 46450785
Ventricular fibrillation 186.09 15.37 110 32500 11386 46642066
Diarrhoea 185.47 15.37 80 32530 559522 46093930
Arthralgia 179.63 15.37 22 32588 364581 46288871
Blood pressure decreased 169.09 15.37 204 32406 56955 46596497
Procedural hypotension 159.32 15.37 51 32559 1151 46652301
Pulseless electrical activity 155.18 15.37 83 32527 7084 46646368
Anaesthetic complication 153.61 15.37 55 32555 1762 46651690
Apnoea 150.55 15.37 82 32528 7257 46646195
Unwanted awareness during anaesthesia 149.98 15.37 36 32574 260 46653192
Metabolic acidosis 144.46 15.37 156 32454 38624 46614828
Fall 137.37 15.37 31 32579 329066 46324386
Dystonia 134.92 15.37 89 32521 11168 46642284
Anaphylactoid shock 133.64 15.37 33 32577 272 46653180
Rheumatoid arthritis 132.85 15.37 9 32601 240206 46413246
Haemodynamic instability 127.86 15.37 75 32535 7650 46645802
Diabetes insipidus 126.27 15.37 50 32560 2124 46651328
Post procedural complication 123.19 15.37 96 32514 15633 46637819
Procedural complication 114.96 15.37 60 32550 4870 46648582
Rhabdomyolysis 113.29 15.37 143 32467 41766 46611686
Airway complication of anaesthesia 113.09 15.37 27 32583 190 46653262
Laryngospasm 112.82 15.37 50 32560 2823 46650629
Headache 110.74 15.37 103 32507 478249 46175203
Electrocardiogram ST segment elevation 106.78 15.37 52 32558 3643 46649809
Hypoxia 105.36 15.37 154 32456 51684 46601768
Respiratory acidosis 105.21 15.37 61 32549 6087 46647365
Joint swelling 102.23 15.37 3 32607 166070 46487382
Labile blood pressure 101.83 15.37 40 32570 1663 46651789
Anaphylactoid reaction 97.50 15.37 48 32562 3443 46650009
Clonus 96.12 15.37 50 32560 4030 46649422
Malaise 94.98 15.37 57 32553 331175 46322277
Hypoventilation 92.93 15.37 49 32561 4061 46649391
Pain in extremity 91.91 15.37 33 32577 258647 46394805
Dizziness 90.25 15.37 64 32546 340350 46313102
Myoclonus 90.08 15.37 77 32533 14275 46639177
Nausea 89.52 15.37 220 32390 687234 45966218
Product dose omission issue 85.75 15.37 9 32601 168511 46484941
Nasopharyngitis 84.41 15.37 6 32604 153992 46499460
Alopecia 84.40 15.37 8 32602 162406 46491046
PCO2 increased 84.03 15.37 32 32578 1222 46652230
Type I hypersensitivity 83.12 15.37 38 32572 2308 46651144
Tryptase increased 83.10 15.37 21 32589 192 46653260
Drug intolerance 82.75 15.37 5 32605 147044 46506408
Generalised tonic-clonic seizure 82.10 15.37 98 32512 27024 46626428
Renal ischaemia 81.62 15.37 26 32584 577 46652875
Arteriospasm coronary 81.39 15.37 43 32567 3578 46649874
Weight decreased 79.97 15.37 24 32586 210825 46442627
Respiratory failure 79.90 15.37 193 32417 94623 46558829
Transmission of an infectious agent via product 78.44 15.37 18 32592 104 46653348
Unresponsive to stimuli 76.38 15.37 103 32507 32071 46621381
Anticholinergic syndrome 76.00 15.37 33 32577 1773 46651679
Cardiogenic shock 75.63 15.37 74 32536 16310 46637142
Intestinal ischaemia 74.00 15.37 51 32559 6874 46646578
Opisthotonus 73.55 15.37 21 32589 316 46653136
Anaesthetic complication pulmonary 72.28 15.37 15 32595 49 46653403
Oliguria 71.94 15.37 55 32555 8704 46644748
Product contamination 71.72 15.37 23 32587 522 46652930
Mitochondrial DNULL mutation 70.21 15.37 19 32591 232 46653220
Ventricular hypokinesia 68.55 15.37 40 32570 4038 46649414
Dyspnoea 68.51 15.37 163 32447 515385 46138067
Sinusitis 68.46 15.37 6 32604 129762 46523690
Seizure 68.33 15.37 215 32395 122839 46530613
Blood creatine phosphokinase increased 67.71 15.37 90 32520 27634 46625818
Pain 66.41 15.37 147 32463 476801 46176651
Insomnia 65.82 15.37 17 32593 164907 46488545
Respiratory arrest 65.15 15.37 98 32512 33718 46619734
PO2 increased 64.31 15.37 24 32586 866 46652586
Blood gases abnormal 64.24 15.37 22 32588 616 46652836
Weight increased 63.66 15.37 18 32592 164455 46488997
Peripheral swelling 63.64 15.37 16 32594 158055 46495397
Abdominal discomfort 63.43 15.37 14 32596 151151 46502301
Intra-abdominal pressure increased 63.16 15.37 17 32593 203 46653249
Cardio-respiratory arrest 61.67 15.37 132 32478 59737 46593715
Encephalopathy 61.40 15.37 95 32515 33494 46619958
Blood pH decreased 61.33 15.37 32 32578 2595 46650857
Decreased appetite 60.36 15.37 30 32580 193806 46459646
Oculogyric crisis 60.08 15.37 25 32585 1208 46652244
Hyperreflexia 59.24 15.37 40 32570 5214 46648238
Agitation 59.19 15.37 124 32486 55291 46598161
Stridor 58.61 15.37 33 32577 3114 46650338
Drug ineffective for unapproved indication 57.56 15.37 64 32546 16349 46637103
Oxygen saturation abnormal 57.49 15.37 31 32579 2687 46650765
Dyskinesia 57.39 15.37 85 32525 28840 46624612
Constipation 57.20 15.37 25 32585 174072 46479380
Disseminated intravascular coagulation 56.41 15.37 68 32542 18937 46634515
Torsade de pointes 56.29 15.37 55 32555 12099 46641353
Pneumatosis 55.98 15.37 18 32592 412 46653040
Endotracheal intubation complication 55.94 15.37 18 32592 413 46653039
Pulmonary oedema 55.33 15.37 115 32495 50990 46602462
Anaesthetic complication neurological 55.29 15.37 15 32595 185 46653267
Acute respiratory distress syndrome 54.82 15.37 72 32538 21850 46631602
End-tidal CO2 decreased 54.80 15.37 10 32600 12 46653440
Bronchitis 53.02 15.37 6 32604 105973 46547479
Vasoplegia syndrome 52.73 15.37 22 32588 1070 46652382
Erythema 52.39 15.37 218 32392 142602 46510850
Septic shock 52.16 15.37 121 32489 57772 46595680
Carcinoid crisis 51.98 15.37 15 32595 235 46653217
Laryngeal oedema 51.78 15.37 37 32573 5282 46648170
Death 51.21 15.37 98 32512 335450 46318002
Ventricular extrasystoles 51.12 15.37 50 32560 11013 46642439
Exposure during pregnancy 51.07 15.37 179 32431 108033 46545419
Sinus tachycardia 50.91 15.37 69 32541 21580 46631872
Pneumonia 49.87 15.37 119 32491 376201 46277251
Brain oedema 49.62 15.37 52 32558 12426 46641026
Maternal exposure during pregnancy 48.71 15.37 170 32440 102379 46551073
Pruritus 48.28 15.37 59 32551 242293 46411159
Upper airway obstruction 48.12 15.37 17 32593 523 46652929
Atrioventricular block complete 48.02 15.37 41 32569 7586 46645866
Influenza 47.42 15.37 4 32606 89266 46564186
Foetal death 47.05 15.37 43 32567 8700 46644752
Gene mutation 46.31 15.37 20 32590 1060 46652392
Muscle rigidity 45.99 15.37 45 32565 9916 46643536
Acute hepatic failure 45.87 15.37 54 32556 14667 46638785
Hepatic ischaemia 45.36 15.37 16 32594 490 46652962
Postoperative delirium 45.30 15.37 10 32600 47 46653405
Coagulopathy 45.08 15.37 60 32550 18439 46635013
Renal impairment 45.03 15.37 134 32476 74238 46579214
Acute pulmonary oedema 44.81 15.37 40 32570 7851 46645601
Urinary tract infection 44.53 15.37 53 32557 220213 46433239
Arthropathy 44.43 15.37 4 32606 84696 46568756
Electrocardiogram QRS complex prolonged 44.27 15.37 34 32576 5415 46648037
Neuromuscular blockade 43.98 15.37 14 32596 310 46653142
Mydriasis 43.80 15.37 45 32565 10508 46642944
Psoriasis 43.23 15.37 3 32607 78601 46574851
Therapeutic product effect prolonged 43.19 15.37 14 32596 329 46653123
Back pain 43.03 15.37 50 32560 209989 46443463
Gait disturbance 42.96 15.37 24 32586 145239 46508213
Suspected product quality issue 42.90 15.37 12 32598 167 46653285
Multiple-drug resistance 42.69 15.37 25 32585 2540 46650912
Blood bicarbonate decreased 42.52 15.37 26 32584 2859 46650593
Acute generalised exanthematous pustulosis 42.51 15.37 42 32568 9363 46644089
Cardiovascular insufficiency 42.17 15.37 20 32590 1321 46652131
Local anaesthetic systemic toxicity 41.86 15.37 14 32596 364 46653088
Asthenia 41.47 15.37 98 32512 310977 46342475
Contusion 41.23 15.37 6 32604 87481 46565971
Mental status changes postoperative 40.72 15.37 12 32598 203 46653249
Necrosis ischaemic 40.72 15.37 17 32593 828 46652624
Chest pain 40.59 15.37 38 32572 176286 46477166
Product contamination microbial 39.98 15.37 12 32598 217 46653235
Confusion postoperative 39.87 15.37 12 32598 219 46653233
Myoclonic epilepsy 39.28 15.37 17 32593 906 46652546
Acidosis hyperchloraemic 39.27 15.37 13 32597 327 46653125
Electrocardiogram ST segment depression 39.00 15.37 24 32586 2669 46650783
Fear 38.72 15.37 52 32558 16120 46637332
Hepatorenal failure 38.47 15.37 15 32595 611 46652841
Shock haemorrhagic 38.03 15.37 38 32572 8586 46644866
Hepatitis acute 37.72 15.37 37 32573 8177 46645275
Injection site pain 37.43 15.37 14 32596 107138 46546314
Laryngeal stenosis 37.05 15.37 15 32595 675 46652777
Neuropathy peripheral 36.95 15.37 9 32601 90884 46562568
Procedural nausea 36.89 15.37 15 32595 683 46652769
Hepatorenal syndrome 36.52 15.37 20 32590 1788 46651664
Neutropenia 36.46 15.37 28 32582 143176 46510276
Stomatitis 36.44 15.37 3 32607 68294 46585158
Electroencephalogram abnormal 36.28 15.37 26 32584 3728 46649724
Pulse absent 36.11 15.37 29 32581 4927 46648525
Oedema peripheral 36.07 15.37 35 32575 159671 46493781
Musculoskeletal stiffness 35.60 15.37 12 32598 97981 46555471
Left ventricle outflow tract obstruction 35.56 15.37 11 32599 221 46653231
Posterior reversible encephalopathy syndrome 35.20 15.37 48 32562 15093 46638359
Angioedema 35.17 15.37 82 32528 39260 46614192
Perforation 35.01 15.37 16 32594 971 46652481
Wrong product administered 34.90 15.37 30 32580 5600 46647852
Subcutaneous emphysema 34.43 15.37 15 32595 812 46652640
Left ventricular dysfunction 34.27 15.37 39 32571 10216 46643236
Malignant neoplasm progression 34.23 15.37 3 32607 64923 46588529
Hypocapnia 34.22 15.37 12 32598 361 46653091
Infusion related reaction 34.07 15.37 14 32596 101194 46552258
Paralysis 34.06 15.37 36 32574 8685 46644767
Hepatocellular injury 33.79 15.37 68 32542 29454 46623998
Hypercapnia 33.56 15.37 27 32583 4599 46648853
Disease progression 33.48 15.37 11 32599 91289 46562163
Muscle twitching 33.34 15.37 46 32564 14626 46638826
Renal injury 33.10 15.37 37 32573 9504 46643948
Cardiac output decreased 33.03 15.37 15 32595 897 46652555
Myxoedema coma 32.97 15.37 12 32598 403 46653049
Airway peak pressure increased 32.92 15.37 11 32599 285 46653167
Unmasking of previously unidentified disease 32.87 15.37 14 32596 717 46652735
Blood lactic acid increased 32.77 15.37 29 32581 5628 46647824
Dehydration 32.64 15.37 38 32572 159502 46493950
Delirium 32.63 15.37 77 32533 37151 46616301
Skin test positive 32.56 15.37 14 32596 734 46652718
Muscle relaxant therapy 32.53 15.37 9 32601 120 46653332
Hepatitis 31.98 15.37 70 32540 32145 46621307
Inappropriate schedule of product administration 31.72 15.37 4 32606 65009 46588443
Coma scale abnormal 31.69 15.37 27 32583 4979 46648473
Maternal exposure during delivery 31.39 15.37 14 32596 802 46652650
Procedural haemorrhage 31.37 15.37 20 32590 2366 46651086
Herpes zoster 31.19 15.37 5 32605 67867 46585585
Feeling abnormal 31.14 15.37 25 32585 125035 46528417
Extravasation 31.01 15.37 19 32591 2096 46651356
Injection site erythema 30.98 15.37 7 32603 74420 46579032
Swelling 30.86 15.37 25 32585 124486 46528966
Myoglobinuria 30.85 15.37 10 32600 235 46653217
Oropharyngeal pain 30.83 15.37 7 32603 74161 46579291
Altered state of consciousness 30.66 15.37 57 32553 23291 46630161
Procedural vomiting 30.63 15.37 12 32598 495 46652957
Arrhythmia 30.47 15.37 72 32538 34769 46618683
Premature delivery 30.40 15.37 55 32555 22014 46631438
Depression 30.21 15.37 45 32565 170059 46483393
Lipoedema 30.18 15.37 9 32601 159 46653293
Recurrence of neuromuscular blockade 29.76 15.37 8 32602 95 46653357
Systemic lupus erythematosus 29.51 15.37 5 32605 65175 46588277
Haemodilution 29.46 15.37 8 32602 99 46653353
Somatosensory evoked potentials abnormal 28.99 15.37 5 32605 3 46653449
Renal failure 28.90 15.37 156 32454 113438 46540014
Blood pressure immeasurable 28.80 15.37 15 32595 1212 46652240
Coma 28.79 15.37 98 32512 58251 46595201
Hypovolaemia 28.72 15.37 35 32575 9853 46643599
Neuroleptic malignant syndrome 28.53 15.37 37 32573 11085 46642367
Acute postoperative sialadenitis 28.38 15.37 6 32604 22 46653430
Ventricular dysfunction 28.26 15.37 20 32590 2812 46650640
Vitamin K deficiency 28.10 15.37 11 32599 453 46652999
Aspartate aminotransferase increased 27.94 15.37 119 32491 78581 46574871
Abdominal pain 27.89 15.37 76 32534 229955 46423497
Procedural hypertension 27.84 15.37 10 32600 323 46653129
Lower respiratory tract infection 27.84 15.37 3 32607 55086 46598366
Dry mouth 27.74 15.37 3 32607 54923 46598529
Atrioventricular dissociation 27.59 15.37 9 32601 216 46653236
Cyanosis 27.55 15.37 44 32566 15927 46637525
Pupils unequal 27.51 15.37 15 32595 1329 46652123
Asthma 27.23 15.37 15 32595 91527 46561925
Abdominal pain upper 27.22 15.37 37 32573 145268 46508184
Atrioventricular block second degree 27.19 15.37 22 32588 3777 46649675
Anaemia 27.07 15.37 90 32520 255689 46397763
Hypoaesthesia 26.89 15.37 26 32584 118843 46534609
Hypertriglyceridaemia 26.76 15.37 26 32584 5678 46647774
Myoglobin urine present 26.53 15.37 7 32603 77 46653375
Myotonia 26.38 15.37 8 32602 150 46653302
Acute kidney injury 26.34 15.37 266 32344 235589 46417863
Toxic epidermal necrolysis 26.32 15.37 52 32558 22226 46631226
Ultrasound ovary abnormal 26.29 15.37 7 32603 80 46653372
Thyrotoxic crisis 26.18 15.37 12 32598 733 46652719
Syncope 26.02 15.37 21 32589 104782 46548670
Electrocardiogram QT prolonged 26.02 15.37 87 32523 51238 46602214
Oesophageal intramural haematoma 25.98 15.37 7 32603 84 46653368
Hepatic failure 25.97 15.37 66 32544 33350 46620102
Anhedonia 25.92 15.37 34 32576 10301 46643151
Irregular breathing 25.79 15.37 9 32601 267 46653185
Gastrooesophageal reflux disease 25.48 15.37 10 32600 74334 46579118
Contraindicated product administered 25.42 15.37 12 32598 79935 46573517
Hypotensive transfusion reaction 25.28 15.37 6 32604 41 46653411
Gaze palsy 25.23 15.37 14 32596 1284 46652168
Sinus bradycardia 25.20 15.37 39 32571 13743 46639709
Patent ductus arteriosus 24.80 15.37 21 32589 3841 46649611
Bezold-Jarisch reflex 24.67 15.37 5 32605 14 46653438
Intensive care unit acquired weakness 24.67 15.37 11 32599 630 46652822
Diabetes mellitus 24.62 15.37 3 32607 50062 46603390
Hyperammonaemic encephalopathy 24.55 15.37 16 32594 1966 46651486
Coronary artery embolism 24.44 15.37 8 32602 194 46653258
Depressed level of consciousness 24.44 15.37 81 32529 47488 46605964
Post procedural haemorrhage 24.40 15.37 28 32582 7398 46646054
Anaesthetic complication cardiac 24.17 15.37 5 32605 16 46653436
Gastrointestinal disorder 24.01 15.37 6 32604 59570 46593882
Tracheal injury 23.83 15.37 6 32604 54 46653398
Chest discomfort 23.80 15.37 17 32593 90252 46563200
White blood cell count decreased 23.74 15.37 26 32584 112205 46541247
Alanine aminotransferase increased 23.53 15.37 123 32487 88328 46565124
Kounis syndrome 23.46 15.37 13 32597 1189 46652263
Muscle spasms 23.41 15.37 31 32579 123082 46530370
Skin test negative 23.11 15.37 5 32605 21 46653431
Suspected product contamination 23.11 15.37 5 32605 21 46653431
Macroglossia 22.98 15.37 10 32600 540 46652912
Electrocardiogram repolarisation abnormality 22.84 15.37 13 32597 1252 46652200
Trigemino-cardiac reflex 22.83 15.37 4 32606 3 46653449
Air embolism 22.74 15.37 8 32602 243 46653209
Hospitalisation 22.61 15.37 8 32602 63377 46590075
Abscess neck 22.55 15.37 10 32600 565 46652887
Post procedural fever 22.47 15.37 8 32602 252 46653200
Systemic inflammatory response syndrome 22.46 15.37 23 32587 5348 46648104
Vision blurred 22.38 15.37 14 32596 79694 46573758
Foetal exposure during pregnancy 22.12 15.37 59 32551 30688 46622764
Obstructive airways disorder 21.84 15.37 36 32574 13376 46640076
Urticaria 21.77 15.37 149 32461 117743 46535709
Atrioventricular block first degree 21.48 15.37 24 32586 6162 46647290
Neck pain 21.47 15.37 6 32604 55300 46598152
Tachypnoea 21.35 15.37 37 32573 14314 46639138
Palpitations 21.35 15.37 21 32589 95238 46558214
Nasal congestion 21.11 15.37 4 32606 48109 46605343
Cough 21.08 15.37 86 32524 230163 46423289
Premature baby 21.06 15.37 42 32568 18070 46635382
Upper respiratory tract infection 21.05 15.37 9 32601 63547 46589905
Chronic obstructive pulmonary disease 21.03 15.37 7 32603 57626 46595826
Endotracheal intubation 20.93 15.37 15 32595 2150 46651302
Burkholderia test positive 20.79 15.37 6 32604 94 46653358
Supraventricular tachycardia 20.78 15.37 35 32575 13235 46640217
Loss of personal independence in daily activities 20.77 15.37 7 32603 57176 46596276
Dyspepsia 20.68 15.37 11 32599 68461 46584991
Extrasystoles 20.64 15.37 21 32589 4848 46648604
Tidal volume decreased 20.49 15.37 5 32605 39 46653413
Intensive care unit delirium 20.38 15.37 5 32605 40 46653412
Tongue oedema 20.20 15.37 19 32591 3987 46649465
Musculoskeletal pain 20.13 15.37 12 32598 70116 46583336
Medication error 19.94 15.37 57 32553 30854 46622598
Drug use disorder 19.92 15.37 16 32594 2719 46650733
Epistaxis 19.91 15.37 10 32600 64295 46589157
Eosinophilic pneumonia acute 19.83 15.37 8 32602 357 46653095
Respiratory distress 19.77 15.37 58 32552 31858 46621594
Device programming error 19.76 15.37 5 32605 46 46653406
Infantile apnoea 19.69 15.37 10 32600 766 46652686
Cystitis 19.66 15.37 3 32607 42238 46611214
Acidosis 19.57 15.37 31 32579 11143 46642309
Hypovolaemic shock 19.54 15.37 21 32589 5162 46648290
Cardiac massage 19.29 15.37 4 32606 13 46653439
Hypervolaemia 19.15 15.37 13 32597 1709 46651743
Idiosyncratic drug reaction 19.09 15.37 10 32600 817 46652635
Therapeutic product effect incomplete 18.98 15.37 16 32594 78137 46575315
Bispectral index decreased 18.80 15.37 3 32607 0 46653452
Transcranial electrical motor evoked potential monitoring abnormal 18.80 15.37 3 32607 0 46653452
Extubation 18.64 15.37 4 32606 16 46653436
Peripheral nerve palsy 18.64 15.37 4 32606 16 46653436
Administration site extravasation 18.60 15.37 9 32601 621 46652831
Drug-induced liver injury 18.58 15.37 49 32561 25319 46628133
Blood magnesium decreased 18.57 15.37 30 32580 10962 46642490
Lactic acidosis 18.55 15.37 59 32551 33850 46619602
Sepsis syndrome 18.47 15.37 10 32600 874 46652578
Neurological decompensation 18.32 15.37 13 32597 1835 46651617
Long QT syndrome 18.26 15.37 16 32594 3064 46650388
Hypoxic-ischaemic encephalopathy 18.06 15.37 18 32592 4055 46649397
Euthyroid sick syndrome 18.05 15.37 5 32605 67 46653385
Apnoeic attack 17.91 15.37 7 32603 287 46653165
Tracheal haemorrhage 17.90 15.37 6 32604 157 46653295
Uterine atony 17.83 15.37 6 32604 159 46653293
Ischaemic cerebral infarction 17.79 15.37 11 32599 1234 46652218
Mucosal inflammation 17.62 15.37 3 32607 38973 46614479
Hypernatraemia 17.53 15.37 22 32588 6379 46647073
Haematemesis 17.51 15.37 52 32558 28754 46624698
Brain death 17.41 15.37 15 32595 2808 46650644
Systolic dysfunction 17.24 15.37 11 32599 1303 46652149
Balance disorder 17.21 15.37 12 32598 64509 46588943
Face oedema 17.20 15.37 40 32570 19113 46634339
Stevens-Johnson syndrome 17.06 15.37 45 32565 23252 46630200
Haemoperitoneum 16.98 15.37 14 32596 2468 46650984
Ventricular asystole 16.94 15.37 5 32605 85 46653367
Procedural dizziness 16.94 15.37 5 32605 85 46653367
Abdominal sepsis 16.92 15.37 11 32599 1346 46652106
Burning sensation 16.91 15.37 5 32605 44406 46609046
Dry skin 16.78 15.37 4 32606 41012 46612440
Agitation postoperative 16.77 15.37 4 32606 28 46653424
Nerve stimulation test abnormal 16.73 15.37 3 32607 3 46653449
Partial seizures 16.65 15.37 19 32591 4991 46648461
Bone pain 16.58 15.37 6 32604 46884 46606568
Fat embolism 16.44 15.37 6 32604 203 46653249
Acute chest syndrome 16.40 15.37 8 32602 562 46652890
Infection 16.27 15.37 44 32566 133548 46519904
Bradycardia foetal 16.24 15.37 7 32603 369 46653083
Encephalitis autoimmune 16.23 15.37 10 32600 1114 46652338
Migraine 16.20 15.37 15 32595 70011 46583441
Chemical peritonitis 16.18 15.37 5 32605 100 46653352
Hepatitis C 16.18 15.37 21 32589 6297 46647155
Respiratory rate decreased 16.16 15.37 15 32595 3095 46650357
Spinal cord disorder 16.15 15.37 10 32600 1124 46652328
Suicidal ideation 15.69 15.37 10 32600 56372 46597080
Emotional distress 15.51 15.37 52 32558 30655 46622797
Polyuria 15.51 15.37 22 32588 7173 46646279
Myalgia 15.40 15.37 40 32570 123048 46530404
Rhinorrhoea 15.39 15.37 7 32603 47658 46605794

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic shock 1421.32 15.78 535 30087 13458 29908398
Propofol infusion syndrome 1072.81 15.78 234 30388 632 29921224
Anaphylactic reaction 680.70 15.78 398 30224 27584 29894272
Hyperthermia malignant 509.54 15.78 150 30472 1684 29920172
Hypotension 439.17 15.78 755 29867 199810 29722046
Cardiac arrest 406.78 15.78 487 30135 92363 29829493
Bronchospasm 367.13 15.78 189 30433 10149 29911707
Bradycardia 318.84 15.78 363 30259 65163 29856693
Delayed recovery from anaesthesia 306.34 15.78 82 30540 629 29921227
Rhabdomyolysis 290.45 15.78 341 30281 63239 29858617
Serotonin syndrome 268.81 15.78 188 30434 17703 29904153
Anaesthetic complication 222.35 15.78 70 30552 999 29920857
Fatigue 215.95 15.78 35 30587 320638 29601218
Tachycardia 214.64 15.78 317 30305 73422 29848434
Metabolic acidosis 189.56 15.78 212 30410 37249 29884607
Circulatory collapse 176.26 15.78 154 30468 20060 29901796
Ventricular fibrillation 156.00 15.78 127 30495 15011 29906845
Oxygen saturation decreased 148.80 15.78 202 30420 43238 29878618
Neuromuscular block prolonged 142.30 15.78 39 30583 330 29921526
Pulseless electrical activity 142.26 15.78 85 30537 6102 29915754
Blood pressure decreased 131.97 15.78 199 30423 46876 29874980
Diarrhoea 131.24 15.78 91 30531 334012 29587844
Status epilepticus 129.31 15.78 100 30522 10972 29910884
Electrocardiogram ST segment elevation 128.83 15.78 71 30551 4371 29917485
Haemodynamic instability 122.13 15.78 85 30537 7930 29913926
Shock 121.84 15.78 133 30489 22726 29899130
Respiratory depression 113.26 15.78 94 30528 11409 29910447
Fall 107.25 15.78 27 30595 181845 29740011
Death 107.18 15.78 125 30497 357158 29564698
Intensive care unit acquired weakness 101.77 15.78 37 30585 835 29921021
Airway complication of anaesthesia 99.77 15.78 24 30598 112 29921744
Ventricular tachycardia 98.93 15.78 122 30500 23740 29898116
Post procedural complication 95.54 15.78 86 30536 11640 29910216
Arthralgia 92.96 15.78 14 30608 135777 29786079
Decreased appetite 90.81 15.78 21 30601 149889 29771967
Laryngospasm 89.58 15.78 38 30584 1305 29920551
Hypoxia 88.42 15.78 168 30454 47686 29874170
Hypoxic-ischaemic encephalopathy 86.51 15.78 56 30566 4631 29917225
Blood creatine phosphokinase increased 86.08 15.78 158 30464 43690 29878166
Multiple organ dysfunction syndrome 85.80 15.78 196 30426 63291 29858565
Drug interaction 84.42 15.78 415 30207 199153 29722703
Negative pressure pulmonary oedema 83.46 15.78 23 30599 199 29921657
Dizziness 81.90 15.78 49 30573 194860 29726996
Anaphylactoid shock 81.25 15.78 26 30596 392 29921464
Procedural complication 78.77 15.78 52 30570 4445 29917411
Anaesthetic complication neurological 74.11 15.78 23 30599 312 29921544
Fear 73.96 15.78 72 30550 10753 29911103
Arteriospasm coronary 73.59 15.78 41 30581 2577 29919279
Respiratory acidosis 72.18 15.78 48 30574 4154 29917702
Stress cardiomyopathy 71.87 15.78 34 30588 1515 29920341
Injury 71.25 15.78 99 30523 21632 29900224
Hypertriglyceridaemia 71.16 15.78 62 30560 8036 29913820
Diabetes insipidus 71.07 15.78 38 30584 2201 29919655
Apnoea 69.76 15.78 55 30567 6203 29915653
Headache 69.59 15.78 51 30571 182255 29739601
Vasoplegia syndrome 68.65 15.78 31 30591 1240 29920616
Procedural hypotension 68.36 15.78 29 30593 996 29920860
Trigemino-cardiac reflex 66.96 15.78 17 30605 103 29921753
Product dose omission issue 66.12 15.78 8 30614 91623 29830233
Transmission of an infectious agent via product 65.91 15.78 18 30604 150 29921706
Malaise 63.33 15.78 47 30575 166915 29754941
Myoclonus 63.28 15.78 73 30549 13239 29908617
Pulse absent 62.95 15.78 49 30573 5424 29916432
Seizure like phenomena 62.93 15.78 23 30599 527 29921329
Cyanosis 62.80 15.78 69 30553 11866 29909990
Asthenia 62.39 15.78 81 30541 221209 29700647
Brain oedema 62.35 15.78 70 30552 12328 29909528
Renal injury 62.05 15.78 68 30554 11661 29910195
Pain in extremity 61.82 15.78 18 30604 110203 29811653
Drug level changed 60.83 15.78 20 30602 330 29921526
Agitation 60.25 15.78 155 30467 53918 29867938
Tachypnoea 59.64 15.78 75 30547 14877 29906979
Ventricular arrhythmia 57.32 15.78 42 30580 4246 29917610
Anaemia 56.71 15.78 78 30544 207914 29713942
Erythema 56.57 15.78 191 30431 77260 29844596
Nausea 56.45 15.78 139 30483 296818 29625038
Dystonia 56.04 15.78 59 30563 9668 29912188
Kounis syndrome 54.81 15.78 29 30593 1644 29920212
Post procedural fever 54.70 15.78 16 30606 175 29921681
Anhedonia 54.08 15.78 54 30568 8315 29913541
Muscle rigidity 53.43 15.78 59 30563 10202 29911654
Intestinal ischaemia 53.07 15.78 49 30573 6848 29915008
Hypoventilation 53.05 15.78 35 30587 2988 29918868
Autonomic nervous system imbalance 52.39 15.78 32 30590 2389 29919467
Tryptase increased 52.04 15.78 16 30606 210 29921646
Toxic epidermal necrolysis 51.87 15.78 77 30545 17863 29903993
Weight decreased 51.61 15.78 47 30575 150874 29770982
Dyspnoea 49.59 15.78 175 30447 333120 29588736
Blood lactic acid increased 47.95 15.78 43 30579 5787 29916069
Peripheral swelling 47.50 15.78 4 30618 61070 29860786
Respiratory failure 47.29 15.78 216 30406 100426 29821430
Necrosis ischaemic 47.07 15.78 15 30607 223 29921633
Abdominal pain 46.67 15.78 42 30580 135612 29786244
Acute respiratory distress syndrome 46.56 15.78 85 30537 23387 29898469
Cardio-respiratory arrest 46.02 15.78 146 30476 57160 29864696
Sinus arrest 46.01 15.78 25 30597 1495 29920361
Respiratory arrest 45.93 15.78 96 30526 29162 29892694
Endotracheal intubation complication 45.48 15.78 16 30606 327 29921529
Product contamination 45.41 15.78 19 30603 630 29921226
Dehydration 45.25 15.78 36 30586 123503 29798353
Neuropathy peripheral 44.39 15.78 9 30613 70466 29851390
Weight increased 44.31 15.78 11 30611 74902 29846954
Blood pressure measurement 44.21 15.78 13 30609 145 29921711
Sinus tachycardia 44.04 15.78 66 30556 15438 29906418
Hepatorenal failure 43.33 15.78 18 30604 586 29921270
Acidosis 43.21 15.78 53 30569 10248 29911608
Disease progression 43.05 15.78 14 30608 79860 29841996
Oxygen saturation immeasurable 42.05 15.78 10 30612 44 29921812
Malignant neoplasm progression 42.01 15.78 11 30611 72276 29849580
Type I hypersensitivity 41.52 15.78 20 30602 928 29920928
Constipation 41.22 15.78 33 30589 112873 29808983
Anticholinergic syndrome 41.05 15.78 19 30603 805 29921051
Anaesthetic complication cardiac 41.05 15.78 9 30613 25 29921831
Gait disturbance 40.48 15.78 13 30609 74764 29847092
Febrile neutropenia 40.45 15.78 30 30592 106663 29815193
Anaphylactoid reaction 40.05 15.78 26 30596 2160 29919696
Brugada syndrome 39.87 15.78 17 30605 591 29921265
Opisthotonus 39.52 15.78 15 30607 383 29921473
Pneumonia 39.43 15.78 192 30430 334114 29587742
Feeling abnormal 38.45 15.78 6 30616 56750 29865106
Neonatal respiratory depression 38.29 15.78 15 30607 418 29921438
Hyperammonaemia 38.24 15.78 37 30585 5483 29916373
Coma blister 38.15 15.78 10 30612 70 29921786
Pulmonary alveolar haemorrhage 38.05 15.78 40 30582 6541 29915315
Plasma cell myeloma 37.74 15.78 5 30617 53457 29868399
Airway peak pressure increased 37.68 15.78 8 30614 18 29921838
Hypotonic-hyporesponsive episode 37.68 15.78 8 30614 18 29921838
Emotional distress 37.68 15.78 62 30560 15703 29906153
Intracranial pressure increased 37.46 15.78 30 30592 3460 29918396
Hypercapnia 37.11 15.78 31 30591 3793 29918063
Insomnia 37.02 15.78 25 30597 93311 29828545
Superinfection 36.64 15.78 22 30600 1592 29920264
Pulmonary oedema 36.18 15.78 113 30509 43862 29877994
Oedema peripheral 36.10 15.78 33 30589 105799 29816057
Neuromuscular blockade 35.73 15.78 11 30611 145 29921711
Haemodialysis 35.62 15.78 50 30572 11023 29910833
Mean arterial pressure decreased 35.53 15.78 11 30611 148 29921708
White blood cell count decreased 35.33 15.78 21 30601 83926 29837930
Cough 35.32 15.78 46 30576 125596 29796260
Post procedural haemorrhage 35.30 15.78 42 30580 7868 29913988
Back pain 34.99 15.78 32 30590 102564 29819292
Urticaria 34.96 15.78 129 30493 54477 29867379
Areflexia 34.92 15.78 26 30596 2693 29919163
Urinary tract infection 34.58 15.78 16 30606 73643 29848213
Oculocardiac reflex 34.46 15.78 9 30613 62 29921794
Brain injury 34.38 15.78 35 30587 5513 29916343
Cardiac failure congestive 34.29 15.78 22 30600 84385 29837471
Neutropenia 34.19 15.78 49 30573 128491 29793365
Neuroleptic malignant syndrome 33.57 15.78 60 30562 16235 29905621
Therapeutic product effect prolonged 32.87 15.78 12 30610 274 29921582
Postoperative delirium 32.48 15.78 8 30614 42 29921814
Product contamination microbial 32.16 15.78 15 30607 647 29921209
Pancytopenia 32.12 15.78 24 30598 85028 29836828
Procedural haemorrhage 31.47 15.78 23 30599 2315 29919541
Dyskinesia 31.23 15.78 69 30553 21765 29900091
Resuscitation 31.14 15.78 18 30604 1214 29920642
Vomiting 30.90 15.78 118 30504 219700 29702156
Drug use disorder 30.84 15.78 26 30596 3222 29918634
Influenza 30.77 15.78 4 30618 43394 29878462
Delirium 30.33 15.78 101 30521 40530 29881326
Electrocardiogram QT prolonged 30.32 15.78 93 30529 35742 29886114
PCO2 increased 29.75 15.78 14 30608 616 29921240
Electrocardiogram ST-T segment elevation 29.43 15.78 5 30617 0 29921856
Spinal muscular atrophy 29.40 15.78 10 30612 184 29921672
Lactic acidosis 29.26 15.78 84 30538 31129 29890727
Chest pain 29.19 15.78 47 30575 117580 29804276
Acidosis hyperchloraemic 29.05 15.78 11 30611 279 29921577
Nodal rhythm 28.74 15.78 18 30604 1405 29920451
Electrocardiogram T wave inversion 28.57 15.78 21 30601 2133 29919723
Paraesthesia 28.43 15.78 10 30612 54317 29867539
Mucosal ulceration 28.14 15.78 15 30607 863 29920993
Chills 28.03 15.78 147 30475 72191 29849665
Pneumomediastinum 27.29 15.78 19 30603 1772 29920084
Myoglobin blood increased 27.27 15.78 19 30603 1774 29920082
Chromaturia 27.22 15.78 50 30572 13815 29908041
Torsade de pointes 26.98 15.78 35 30587 7155 29914701
Atrioventricular block complete 26.85 15.78 38 30584 8439 29913417
Local anaesthetic systemic toxicity 26.54 15.78 9 30613 164 29921692
Suicidal ideation 26.41 15.78 3 30619 36111 29885745
Subcutaneous emphysema 26.36 15.78 15 30607 982 29920874
Locked-in syndrome 26.25 15.78 10 30612 258 29921598
Muscle spasms 26.19 15.78 17 30605 64821 29857035
Syncope 26.06 15.78 29 30593 84874 29836982
Cellulitis 25.55 15.78 8 30614 46776 29875080
Pseudocholinesterase deficiency 25.49 15.78 6 30616 25 29921831
Suspected product contamination 25.15 15.78 7 30615 63 29921793
Disseminated intravascular coagulation 25.13 15.78 64 30558 22107 29899749
Systemic inflammatory response syndrome 24.78 15.78 32 30590 6514 29915342
Trismus 24.68 15.78 20 30602 2345 29919511
Unevaluable event 24.61 15.78 80 30542 31705 29890151
Electrocardiogram abnormal 24.20 15.78 30 30592 5862 29915994
Spinal cord infarction 24.12 15.78 9 30613 219 29921637
Generalised tonic-clonic seizure 23.80 15.78 58 30564 19493 29902363
Unresponsive to stimuli 23.70 15.78 70 30552 26349 29895507
Brain death 23.67 15.78 20 30602 2486 29919370
Obstructive airways disorder 23.52 15.78 37 30585 9022 29912834
Pruritus 23.42 15.78 54 30568 118150 29803706
Ventricular extrasystoles 23.32 15.78 42 30580 11432 29910424
Hypotonia 23.28 15.78 32 30590 6916 29914940
Sedation complication 23.27 15.78 13 30609 821 29921035
Heparin-induced thrombocytopenia 23.06 15.78 28 30594 5355 29916501
Coronary artery disease 23.01 15.78 11 30611 49701 29872155
Conversion disorder 23.00 15.78 10 30612 365 29921491
Stomatitis 22.98 15.78 5 30617 37274 29884582
Hepatitis fulminant 22.86 15.78 24 30598 3917 29917939
Long QT syndrome 22.82 15.78 19 30603 2314 29919542
Oropharyngeal discomfort 22.80 15.78 16 30606 1511 29920345
Unwanted awareness during anaesthesia 22.76 15.78 6 30616 43 29921813
Weight bearing difficulty 22.69 15.78 13 30609 862 29920994
Nystagmus 22.68 15.78 25 30597 4313 29917543
Suspected product quality issue 22.63 15.78 8 30614 166 29921690
Post-injection delirium sedation syndrome 22.55 15.78 10 30612 383 29921473
Blood catecholamines increased 22.28 15.78 5 30617 16 29921840
Hyperventilation 22.02 15.78 19 30603 2430 29919426
Periorbital swelling 21.70 15.78 8 30614 188 29921668
Neuromyopathy 21.42 15.78 13 30609 959 29920897
Myocardial infarction 21.35 15.78 62 30560 125563 29796293
Acute pulmonary oedema 21.35 15.78 32 30590 7483 29914373
Inappropriate schedule of product administration 21.33 15.78 7 30615 39721 29882135
Recurrence of neuromuscular blockade 21.15 15.78 7 30615 118 29921738
Drug intolerance 21.00 15.78 10 30612 45281 29876575
Air embolism 20.88 15.78 7 30615 123 29921733
Seizure 20.88 15.78 172 30450 98303 29823553
Priapism 20.86 15.78 25 30597 4718 29917138
Bronchitis 20.82 15.78 7 30615 39118 29882738
Dialysis 20.77 15.78 39 30583 10957 29910899
Depression 20.72 15.78 38 30584 90399 29831457
Hypothermia 20.70 15.78 36 30586 9531 29912325
Migraine with aura 20.60 15.78 10 30612 472 29921384
Renal impairment 20.59 15.78 152 30470 84032 29837824
Electrocardiogram ST segment depression 20.58 15.78 18 30604 2344 29919512
Neutrophil count decreased 20.26 15.78 9 30613 42445 29879411
Chronic obstructive pulmonary disease 20.17 15.78 11 30611 46115 29875741
Mydriasis 20.14 15.78 28 30594 6115 29915741
Continuous haemodiafiltration 19.93 15.78 13 30609 1088 29920768
Premature recovery from anaesthesia 19.89 15.78 4 30618 6 29921850
Clonus 19.81 15.78 18 30604 2463 29919393
Diabetes mellitus 19.79 15.78 9 30613 41856 29880000
Contusion 19.68 15.78 4 30618 31276 29890580
Incorrect drug administration rate 19.56 15.78 13 30609 1123 29920733
Depressed level of consciousness 19.39 15.78 84 30538 38138 29883718
Musculoskeletal pain 19.37 15.78 4 30618 30936 29890920
Capillary nail refill test abnormal 19.20 15.78 5 30617 34 29921822
End-tidal CO2 increased 19.16 15.78 4 30618 8 29921848
Respiratory tract infection bacterial 19.16 15.78 10 30612 551 29921305
Laryngeal oedema 18.90 15.78 20 30602 3294 29918562
Haemoglobin decreased 18.89 15.78 57 30565 114041 29807815
Treatment failure 18.81 15.78 6 30616 34673 29887183
Acute kidney injury 18.78 15.78 388 30234 273454 29648402
Epistaxis 18.68 15.78 16 30606 52965 29868891
Stress 18.52 15.78 54 30568 20181 29901675
Abdominal pain upper 18.50 15.78 22 30600 62529 29859327
Hypoglycaemia 18.46 15.78 15 30607 50966 29870890
Systolic anterior motion of mitral valve 18.38 15.78 5 30617 41 29921815
Hypocapnia 18.19 15.78 6 30616 100 29921756
Pupil fixed 18.08 15.78 15 30607 1817 29920039
Transcranial electrical motor evoked potential monitoring abnormal 18.01 15.78 4 30618 12 29921844
Septic shock 17.99 15.78 119 30503 63488 29858368
Palpitations 17.87 15.78 6 30616 33567 29888289
Skin test negative 17.77 15.78 5 30617 47 29921809
Hyperkalaemia 17.77 15.78 122 30500 65888 29855968
Pulmonary embolism 17.74 15.78 33 30589 78102 29843754
Dyspnoea exertional 17.73 15.78 7 30615 35423 29886433
Fear of death 17.66 15.78 10 30612 648 29921208
Light anaesthesia 17.66 15.78 3 30619 0 29921856
Therapeutic response prolonged 17.66 15.78 3 30619 0 29921856
Coma 17.63 15.78 85 30537 40364 29881492
Congenital megaureter 17.61 15.78 6 30616 111 29921745
Coagulopathy 17.56 15.78 50 30572 18437 29903419
Respiratory alkalosis 17.17 15.78 13 30609 1381 29920475
Blood pressure systolic decreased 17.06 15.78 20 30602 3687 29918169
Hepatitis 17.06 15.78 56 30566 22300 29899556
Renal failure 16.97 15.78 204 30418 128762 29793094
Thyrotoxic crisis 16.83 15.78 8 30614 360 29921496
Herpes zoster 16.56 15.78 5 30617 29938 29891918
General physical health deterioration 16.49 15.78 50 30572 99894 29821962
Cardiogenic shock 16.40 15.78 46 30576 16815 29905041
Anaesthetic complication pulmonary 16.40 15.78 4 30618 20 29921836
Electrocardiogram QRS complex prolonged 16.33 15.78 21 30601 4256 29917600
Hypertransaminasaemia 16.31 15.78 20 30602 3865 29917991
Upper airway obstruction 16.19 15.78 9 30613 563 29921293
Myoglobinuria 16.04 15.78 10 30612 774 29921082
Dysgeusia 15.96 15.78 3 30619 24798 29897058
Periventricular haemorrhage neonatal 15.79 15.78 4 30618 24 29921832
Hepatitis acute 15.78 15.78 27 30595 7056 29914800

Pharmacologic Action:

SourceCodeDescription
ATC N01AX10 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Other general anesthetics
FDA EPC N0000175681 General Anesthetic
MeSH PA D000777 Anesthetics
MeSH PA D018686 Anesthetics, Intravenous
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D006993 Hypnotics and Sedatives
FDA PE N0000175975 General Anesthesia
CHEBI has role CHEBI:35623 antiepileptic
CHEBI has role CHEBI:35717 sedatives
CHEBI has role CHEBI:38877 intravenous anesthetics
CHEBI has role CHEBI:48578 free-radical scavenger
CHEBI has role CHEBI:50919 antiemetico

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003
Sedation in Intubated Patients indication
Sedation as Adjunct to Anesthesia indication
Apnea contraindication 1023001
Asthenia contraindication 13791008
Hypovolemia contraindication 28560003
Low blood pressure contraindication 45007003
Cerebral arteriosclerosis contraindication 65312002
Decreased respiratory function contraindication 80954004
Epilepsy contraindication 84757009 DOID:1826
Myocardial dysfunction contraindication 233928007
Disorder of lipid metabolism contraindication 267431006
Hypoxia contraindication 389086002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.8 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA A receptor alpha-2/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 4.95 CHEMBL CHEMBL
GABA-A receptor alpha-1/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 5.39 CHEMBL CHEMBL
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 5.70 CHEMBL CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 5.22 DRUG MATRIX
Cytochrome P450 2C9 Enzyme IC50 4.91 WOMBAT-PK
Carbonic anhydrase 1 Enzyme IC50 4.71 WOMBAT-PK
Carbonic anhydrase 2 Enzyme IC50 4.01 WOMBAT-PK
Fatty-acid amide hydrolase 1 Enzyme IC50 4.28 WOMBAT-PK
Prostaglandin G/H synthase 1 Enzyme IC50 5.42 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.03 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 5.46 DRUG MATRIX
Arachidonate 15-lipoxygenase Enzyme IC50 5.12 DRUG MATRIX
Fatty-acid amide hydrolase 1 Enzyme IC50 4.85 CHEMBL
GABA-A receptor; anion channel Ion channel IC50 5.40 CHEMBL
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Ion channel BLOCKER IC50 5.20 IUPHAR

External reference:

IDSource
4019500 VUID
N0000147620 NUI
D00549 KEGG_DRUG
4019500 VANDF
C0678120 UMLSCUI
CHEBI:44915 CHEBI
PFL PDB_CHEM_ID
CHEMBL526 ChEMBL_ID
4943 PUBCHEM_CID
D015742 MESH_DESCRIPTOR_UI
DB00818 DRUGBANK_ID
5464 IUPHAR_LIGAND_ID
5073 INN_ID
YI7VU623SF UNII
196459 RXNORM
14179 MMSL
5372 MMSL
65 MMSL
d00933 MMSL
003528 NDDF
387423006 SNOMEDCT_US
74674007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0069-0209 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 26 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0069-0234 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 26 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0069-0248 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 26 sections
Propofol Lipuro HUMAN PRESCRIPTION DRUG LABEL 1 0264-4850 INJECTION, EMULSION 10 mg INTRAVENOUS unapproved drug other 3 sections
PROPOFOL HUMAN PRESCRIPTION DRUG LABEL 1 0409-4699 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 26 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0591-2136 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 26 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0641-6194 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 24 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0641-6195 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 24 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0641-6196 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 24 sections
Fresenius Propoven 2% HUMAN PRESCRIPTION DRUG LABEL 1 18124-027 EMULSION 20 mg INTRAVENOUS unapproved drug other 2 sections
propofol HUMAN PRESCRIPTION DRUG LABEL 1 25021-608 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 27 sections
Propofol Injectable Emulsion HUMAN PRESCRIPTION DRUG LABEL 1 43598-265 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 22 sections
Propofol Injectable Emulsion HUMAN PRESCRIPTION DRUG LABEL 1 43598-548 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 22 sections
Propofol Injectable Emulsion HUMAN PRESCRIPTION DRUG LABEL 1 43598-549 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 22 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 50090-4569 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 27 sections
PROPOFOL HUMAN PRESCRIPTION DRUG LABEL 1 51662-1293 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 14 sections
PROPOFOL HUMAN PRESCRIPTION DRUG LABEL 1 51662-1470 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 14 sections
PROPOFOL HUMAN PRESCRIPTION DRUG LABEL 1 51662-1471 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 14 sections
PROPOFOL HUMAN PRESCRIPTION DRUG LABEL 1 52584-098 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 14 sections
Diprivan HUMAN PRESCRIPTION DRUG LABEL 1 52584-269 INJECTION, EMULSION 10 mg INTRAVENOUS NDA 12 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 52584-699 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 14 sections
Diprivan Human Prescription Drug Label 1 63323-269 INJECTION, EMULSION 10 mg INTRAVENOUS NDA 14 sections
Diprivan Human Prescription Drug Label 1 63323-269 INJECTION, EMULSION 10 mg INTRAVENOUS NDA 14 sections
Diprivan Human Prescription Drug Label 1 63323-269 INJECTION, EMULSION 10 mg INTRAVENOUS NDA 14 sections
Diprivan Human Prescription Drug Label 1 63323-269 INJECTION, EMULSION 10 mg INTRAVENOUS NDA 14 sections
Fresenius Propoven 2% HUMAN PRESCRIPTION DRUG LABEL 1 65219-427 EMULSION 20 mg INTRAVENOUS unapproved drug other 2 sections
Diprivan Human Prescription Drug Label 1 65219-800 INJECTION, EMULSION 10 mg INTRAVENOUS NDA 14 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 72572-583 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 24 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 72572-584 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 24 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 72572-585 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 24 sections