nitrous oxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4238	10024-97-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: nitrous oxide dinitrogen monoxide dinitrogen oxide nitrous oxide, usp	Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream. Molecular weight: 44.01 Formula: N2O CLOGP: -0.90 LIPINSKI: None HAC: 3 HDO: 0 TPSA: 54.46 ALOGS: ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

nitrous oxide
dinitrogen monoxide
dinitrogen oxide
nitrous oxide, usp

Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.

Molecular weight: 44.01
Formula: N2O
CLOGP: -0.90
LIPINSKI: None
HAC: 3
HDO: 0
TPSA: 54.46
ALOGS:
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Choroidal infarction	142.29	45.45	18	1816	67	63487121
Subacute combined cord degeneration	140.31	45.45	20	1814	210	63486978
Hyperthermia malignant	101.21	45.45	18	1816	816	63486372
Leukoencephalopathy	91.58	45.45	22	1812	4391	63482797
Lipodystrophy acquired	85.20	45.45	17	1817	1435	63485753
Drug interaction	84.17	45.45	62	1772	229069	63258119
Cardiac arrest	82.38	45.45	44	1790	92501	63394687
Bladder agenesis	66.89	45.45	10	1824	149	63487039
Genitalia external ambiguous	66.46	45.45	10	1824	156	63487032
Cloacal exstrophy	66.46	45.45	10	1824	156	63487032

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Subacute combined cord degeneration	330.61	40.80	43	1645	109	34955134
Choroidal infarction	139.36	40.80	19	1669	76	34955167
Myelopathy	87.61	40.80	21	1667	2476	34952767
Hyperthermia malignant	79.96	40.80	19	1669	2158	34953085
Vitamin B12 deficiency	72.96	40.80	20	1668	4011	34951232
Anaesthetic complication	69.50	40.80	15	1673	1105	34954138
Laryngospasm	49.27	40.80	12	1676	1509	34953734
Drug use disorder	45.57	40.80	14	1674	4177	34951066
Drug abuse	43.78	40.80	37	1651	99059	34856184
Bradycardia	41.43	40.80	32	1656	75386	34879857

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Subacute combined cord degeneration	432.45	34.22	59	3300	282	79740747
Choroidal infarction	276.64	34.22	37	3322	147	79740882
Hyperthermia malignant	140.71	34.22	31	3328	2886	79738143
Myelopathy	131.54	34.22	32	3327	4601	79736428
Vitamin B12 deficiency	122.03	34.22	33	3326	7208	79733821
Cardiac arrest	105.84	34.22	74	3285	172022	79569007
Anaesthetic complication	92.76	34.22	22	3337	2837	79738192
Drug interaction	72.43	34.22	88	3271	415095	79325934
Laryngospasm	71.02	34.22	19	3340	3978	79737051
Leukoencephalopathy	70.53	34.22	22	3337	7907	79733122

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	N01AX13	NERVOUS SYSTEM ANESTHETICS ANESTHETICS, GENERAL Other general anesthetics
ATC	N01AX63	NERVOUS SYSTEM ANESTHETICS ANESTHETICS, GENERAL Other general anesthetics
CHEBI has role	CHEBI:35620	vasodilator agents
CHEBI has role	CHEBI:38869	general anaesthetic
CHEBI has role	CHEBI:38870	inhalation anesthetics
CHEBI has role	CHEBI:60643	N-methyl-D-aspartate receptor antagonists
CHEBI has role	CHEBI:76413	greenhouse gases
CHEBI has role	CHEBI:77971	food raising agent
CHEBI has role	CHEBI:77974	food packaging gases
CHEBI has role	CHEBI:78017	food propellants

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Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

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🐶 Veterinary products

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Product	Applicant	Ingredients
None (Med Gas)	Air Liquide America Specialty Gases	2
None (Med Gas)	Nitrous Oxide Corp	2
None (Med Gas)	Nitrous Oxide of Canada	2
None (Med Gas)	Strata Medical Innovations	2
None (Med Gas)	Praxair Mexico, S. de R.L. de C.V.	2

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Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
N2O	PDB_CHEM_ID
001387	NDDF
111132001	SNOMEDCT_US
388185005	SNOMEDCT_US
4019137	VUID
4019137	VANDF
7486	RXNORM
948	PUBCHEM_CID
C0028215	UMLSCUI
CHEBI:17045	CHEBI

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
NITROUS OXIDE	HUMAN PRESCRIPTION DRUG LABEL	1	10006-002	GAS	99 L	RESPIRATORY (INHALATION)	unapproved medical gas	1 sections
Nitrous Oxide	HUMAN PRESCRIPTION DRUG LABEL	1	10014-003	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrous Oxide	HUMAN PRESCRIPTION DRUG LABEL	1	10014-003	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
NITROUS OXIDE	HUMAN PRESCRIPTION DRUG LABEL	1	10167-200	GAS	99 L	RESPIRATORY (INHALATION)	NDA	1 sections
NITROUS OXIDE	HUMAN PRESCRIPTION DRUG LABEL	1	10167-200	GAS	99 L	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrous Oxide	HUMAN PRESCRIPTION DRUG LABEL	1	10252-003	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrous Oxide	HUMAN PRESCRIPTION DRUG LABEL	1	10252-003	GAS	990 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrous Oxide	HUMAN PRESCRIPTION DRUG LABEL	1	10678-006	GAS	992 mL	RESPIRATORY (INHALATION)	unapproved medical gas	1 sections
Nitrous Oxide	HUMAN PRESCRIPTION DRUG LABEL	1	10736-017	GAS	995 mL	RESPIRATORY (INHALATION)	NDA	1 sections
Nitrous Oxide	HUMAN PRESCRIPTION DRUG LABEL	1	10736-017	GAS	995 mL	RESPIRATORY (INHALATION)	NDA	1 sections

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