nitrous oxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4238 | 10024-97-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Choroidal infarction | 142.29 | 45.45 | 18 | 1816 | 67 | 63487121 |
| Subacute combined cord degeneration | 140.31 | 45.45 | 20 | 1814 | 210 | 63486978 |
| Hyperthermia malignant | 101.21 | 45.45 | 18 | 1816 | 816 | 63486372 |
| Leukoencephalopathy | 91.58 | 45.45 | 22 | 1812 | 4391 | 63482797 |
| Lipodystrophy acquired | 85.20 | 45.45 | 17 | 1817 | 1435 | 63485753 |
| Drug interaction | 84.17 | 45.45 | 62 | 1772 | 229069 | 63258119 |
| Cardiac arrest | 82.38 | 45.45 | 44 | 1790 | 92501 | 63394687 |
| Bladder agenesis | 66.89 | 45.45 | 10 | 1824 | 149 | 63487039 |
| Cloacal exstrophy | 66.46 | 45.45 | 10 | 1824 | 156 | 63487032 |
| Genitalia external ambiguous | 66.46 | 45.45 | 10 | 1824 | 156 | 63487032 |
| Meconium stain | 64.55 | 45.45 | 10 | 1824 | 191 | 63486997 |
| Congenital ectopic bladder | 62.81 | 45.45 | 9 | 1825 | 98 | 63487090 |
| Disinhibition | 61.91 | 45.45 | 12 | 1822 | 871 | 63486317 |
| Tethered cord syndrome | 61.09 | 45.45 | 10 | 1824 | 274 | 63486914 |
| Gastrointestinal disorder congenital | 60.14 | 45.45 | 9 | 1825 | 135 | 63487053 |
| Congenital genital malformation | 59.42 | 45.45 | 9 | 1825 | 147 | 63487041 |
| Caudal regression syndrome | 58.29 | 45.45 | 9 | 1825 | 168 | 63487020 |
| Gastrointestinal malformation | 57.74 | 45.45 | 9 | 1825 | 179 | 63487009 |
| Anal atresia | 57.72 | 45.45 | 10 | 1824 | 388 | 63486800 |
| Epilepsy with myoclonic-atonic seizures | 54.45 | 45.45 | 8 | 1826 | 105 | 63487083 |
| Meningomyelocele | 53.33 | 45.45 | 10 | 1824 | 608 | 63486580 |
| Umbilical cord abnormality | 52.63 | 45.45 | 10 | 1824 | 653 | 63486535 |
| Brain oedema | 50.57 | 45.45 | 18 | 1816 | 14177 | 63473011 |
| Neural tube defect | 49.81 | 45.45 | 8 | 1826 | 194 | 63486994 |
| Vitamin B12 deficiency | 49.42 | 45.45 | 14 | 1820 | 5289 | 63481899 |
| Exomphalos | 47.98 | 45.45 | 9 | 1825 | 548 | 63486640 |
| Apnoea | 47.85 | 45.45 | 15 | 1819 | 8007 | 63479181 |
| Anencephaly | 46.46 | 45.45 | 8 | 1826 | 299 | 63486889 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Subacute combined cord degeneration | 330.61 | 40.80 | 43 | 1645 | 109 | 34955134 |
| Choroidal infarction | 139.36 | 40.80 | 19 | 1669 | 76 | 34955167 |
| Myelopathy | 87.61 | 40.80 | 21 | 1667 | 2476 | 34952767 |
| Hyperthermia malignant | 79.96 | 40.80 | 19 | 1669 | 2158 | 34953085 |
| Vitamin B12 deficiency | 72.96 | 40.80 | 20 | 1668 | 4011 | 34951232 |
| Anaesthetic complication | 69.50 | 40.80 | 15 | 1673 | 1105 | 34954138 |
| Laryngospasm | 49.27 | 40.80 | 12 | 1676 | 1509 | 34953734 |
| Drug use disorder | 45.57 | 40.80 | 14 | 1674 | 4177 | 34951066 |
| Drug abuse | 43.78 | 40.80 | 37 | 1651 | 99059 | 34856184 |
| Bradycardia | 41.43 | 40.80 | 32 | 1656 | 75386 | 34879857 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Subacute combined cord degeneration | 432.45 | 34.22 | 59 | 3300 | 282 | 79740747 |
| Choroidal infarction | 276.64 | 34.22 | 37 | 3322 | 147 | 79740882 |
| Hyperthermia malignant | 140.71 | 34.22 | 31 | 3328 | 2886 | 79738143 |
| Myelopathy | 131.54 | 34.22 | 32 | 3327 | 4601 | 79736428 |
| Vitamin B12 deficiency | 122.03 | 34.22 | 33 | 3326 | 7208 | 79733821 |
| Cardiac arrest | 105.84 | 34.22 | 74 | 3285 | 172022 | 79569007 |
| Anaesthetic complication | 92.76 | 34.22 | 22 | 3337 | 2837 | 79738192 |
| Drug interaction | 72.43 | 34.22 | 88 | 3271 | 415095 | 79325934 |
| Laryngospasm | 71.02 | 34.22 | 19 | 3340 | 3978 | 79737051 |
| Leukoencephalopathy | 70.53 | 34.22 | 22 | 3337 | 7907 | 79733122 |
| Bradycardia | 64.49 | 34.22 | 50 | 3309 | 135507 | 79605522 |
| Delayed recovery from anaesthesia | 54.92 | 34.22 | 13 | 3346 | 1660 | 79739369 |
| Epilepsy with myoclonic-atonic seizures | 51.22 | 34.22 | 8 | 3351 | 108 | 79740921 |
| Drug abuse | 50.59 | 34.22 | 47 | 3312 | 162644 | 79578385 |
| Neuromuscular block prolonged | 49.95 | 34.22 | 11 | 3348 | 1019 | 79740010 |
| Vitamin B12 decreased | 49.91 | 34.22 | 14 | 3345 | 3491 | 79737538 |
| Apnoea | 47.30 | 34.22 | 18 | 3341 | 11686 | 79729343 |
| Drug use disorder | 44.91 | 34.22 | 16 | 3343 | 8635 | 79732394 |
| Disinhibition | 44.50 | 34.22 | 12 | 3347 | 2586 | 79738443 |
| Neuromuscular blockade | 44.22 | 34.22 | 9 | 3350 | 571 | 79740458 |
| Ventricular tachycardia | 43.10 | 34.22 | 25 | 3334 | 41910 | 79699119 |
| Pulmonary oedema | 40.72 | 34.22 | 32 | 3327 | 88222 | 79652807 |
| Blood homocysteine increased | 40.64 | 34.22 | 8 | 3351 | 428 | 79740601 |
| Air embolism | 40.44 | 34.22 | 8 | 3351 | 439 | 79740590 |
| Substance use | 39.95 | 34.22 | 9 | 3350 | 925 | 79740104 |
| Change in seizure presentation | 39.21 | 34.22 | 8 | 3351 | 514 | 79740515 |
| Neuropathy vitamin B12 deficiency | 37.89 | 34.22 | 6 | 3353 | 89 | 79740940 |
| Brain oedema | 36.88 | 34.22 | 19 | 3340 | 25244 | 79715785 |
| Dystonia | 36.84 | 34.22 | 18 | 3341 | 21381 | 79719648 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N01AX13 | NERVOUS SYSTEM ANESTHETICS ANESTHETICS, GENERAL Other general anesthetics |
| ATC | N01AX63 | NERVOUS SYSTEM ANESTHETICS ANESTHETICS, GENERAL Other general anesthetics |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D018712 | Analgesics, Non-Narcotic |
| MeSH PA | D000777 | Anesthetics |
| MeSH PA | D018685 | Anesthetics, Inhalation |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
| CHEBI has role | CHEBI:35620 | vasodilator agents |
| CHEBI has role | CHEBI:38869 | general anaesthetic |
| CHEBI has role | CHEBI:38870 | inhalation anesthetics |
| CHEBI has role | CHEBI:60643 | N-methyl-D-aspartate receptor antagonists |
| CHEBI has role | CHEBI:76413 | greenhouse gases |
| CHEBI has role | CHEBI:77971 | food raising agent |
| CHEBI has role | CHEBI:77974 | food packaging gases |
| CHEBI has role | CHEBI:78017 | food propellants |
| CHEBI has role | CHEBI:78433 | refrigerants |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| None (Med Gas) | Air Liquide America Specialty Gases | 2 |
| None (Med Gas) | Nitrous Oxide Corp | 2 |
| None (Med Gas) | Nitrous Oxide of Canada | 2 |
| None (Med Gas) | Strata Medical Innovations | 2 |
| None (Med Gas) | Praxair Mexico, S. de R.L. de C.V. | 2 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| K50XQU1029 | UNII |
| 4019137 | VUID |
| N0000147387 | NUI |
| D00102 | KEGG_DRUG |
| 4019137 | VANDF |
| C0028215 | UMLSCUI |
| CHEBI:17045 | CHEBI |
| N2O | PDB_CHEM_ID |
| CHEMBL1234579 | ChEMBL_ID |
| 948 | PUBCHEM_CID |
| DB06690 | DRUGBANK_ID |
| D009609 | MESH_DESCRIPTOR_UI |
| 7486 | RXNORM |
| d00934 | MMSL |
| 001387 | NDDF |
| 111132001 | SNOMEDCT_US |
| 388185005 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| NITROUS OXIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10006-002 | GAS | 99 L | RESPIRATORY (INHALATION) | unapproved medical gas | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10014-003 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10014-003 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| NITROUS OXIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10167-200 | GAS | 99 L | RESPIRATORY (INHALATION) | NDA | 1 sections |
| NITROUS OXIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10167-200 | GAS | 99 L | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10252-003 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10252-003 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10678-006 | GAS | 992 mL | RESPIRATORY (INHALATION) | unapproved medical gas | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10736-017 | GAS | 995 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10736-017 | GAS | 995 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| NITROUS OXIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10927-102 | GAS | 99 L | RESPIRATORY (INHALATION) | NDA | 1 sections |
| NITROUS OXIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 11054-007 | GAS | 992 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| NITROUS OXIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 11054-007 | GAS | 992 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| NITROUS OXIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 11054-007 | GAS | 992 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| NITROUS OXIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12121-002 | GAS | 99 L | RESPIRATORY (INHALATION) | NDA | 1 sections |
| NITROUS OXIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12121-002 | GAS | 99 L | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12213-593 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12213-593 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17575-011 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17575-011 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 18482-002 | GAS | 995 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 18482-002 | GAS | 995 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 18482-128 | GAS | 995 mL | RESPIRATORY (INHALATION) | unapproved medical gas | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 20703-003 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 20703-003 | GAS | 990 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21220-122 | GAS | 995 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21220-122 | GAS | 995 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| Nitrous Oxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21220-122 | GAS | 995 mL | RESPIRATORY (INHALATION) | NDA | 1 sections |
| NITROUS OXIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24312-003 | GAS | 99 L | RESPIRATORY (INHALATION) | NDA | 1 sections |
| NITROUS OXIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24312-003 | GAS | 99 L | RESPIRATORY (INHALATION) | NDA | 1 sections |