cyanocobalamin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4196 68-19-9

Description:

MoleculeDescription

Synonyms:

  • cyanocobalamin
  • vitamin B12
  • cobamin
  • cyanocobalamine
  • Molecular weight: 1355.39
  • Formula: C63H88CoN14O14P
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 512.50
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
70 mcg N
1 mg O
20 mcg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 12.50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.42 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Sept. 15, 1949 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1231.98 10.47 4410 646003 179316 62659293
Systemic lupus erythematosus 1157.57 10.47 4719 645694 204199 62634410
Completed suicide 1151.11 10.47 90 650323 145583 62693026
Glossodynia 1020.50 10.47 4078 646335 174798 62663811
Toxicity to various agents 944.36 10.47 693 649720 246557 62592052
Hand deformity 805.55 10.47 3503 646910 155954 62682655
Alopecia 766.73 10.47 5995 644418 331541 62507068
Arthropathy 765.66 10.47 4560 645853 230232 62608377
Abdominal discomfort 764.34 10.47 5763 644650 315122 62523487
Wound 666.38 10.47 3371 647042 159892 62678717
Rheumatoid arthritis 610.87 10.47 4571 645842 249248 62589361
Maternal exposure during pregnancy 547.50 10.47 3995 646418 216067 62622542
Drug interaction 535.88 10.47 954 649459 228177 62610432
Discomfort 503.60 10.47 3185 647228 164189 62674420
Synovitis 499.55 10.47 3453 646960 183465 62655144
Anti-cyclic citrullinated peptide antibody positive 487.65 10.47 2419 647994 113793 62724816
Drug abuse 482.74 10.47 81 650332 72437 62766172
Pericarditis 480.45 10.47 2635 647778 128944 62709665
Swelling 477.05 10.47 4609 645804 270769 62567840
Infusion related reaction 446.89 10.47 4153 646260 241368 62597241
Pain 440.46 10.47 10297 640116 730331 62108278
Intentional overdose 431.65 10.47 113 650300 74039 62764570
Death 426.47 10.47 2179 648234 372202 62466407
Joint swelling 415.27 10.47 5154 645259 322512 62516097
Contraindicated product administered 409.89 10.47 3709 646704 213939 62624670
Febrile neutropenia 311.59 10.47 456 649957 117993 62720616
Rheumatoid factor positive 304.35 10.47 1685 648728 82721 62755888
Overdose 301.75 10.47 444 649969 114634 62723975
Suicide attempt 299.88 10.47 124 650289 60794 62777815
Arthralgia 298.84 10.47 7791 642622 561919 62276690
Duodenal ulcer perforation 295.36 10.47 1712 648701 85497 62753112
Product use issue 293.45 10.47 3502 646911 217018 62621591
Helicobacter infection 287.74 10.47 1780 648633 91005 62747604
Cardiac arrest 261.75 10.47 338 650075 92207 62746402
Psoriatic arthropathy 251.46 10.47 1703 648710 89817 62748792
Acute kidney injury 251.25 10.47 1623 648790 261792 62576817
Hepatic enzyme increased 239.49 10.47 3144 647269 199184 62639425
Depressed level of consciousness 239.21 10.47 172 650241 61906 62776703
Fatigue 238.78 10.47 11243 639170 876785 61961824
Musculoskeletal stiffness 232.10 10.47 2901 647512 181717 62656892
Electrocardiogram QT prolonged 217.78 10.47 174 650239 59356 62779253
Malignant neoplasm progression 205.49 10.47 327 650086 81794 62756815
Nasopharyngitis 202.96 10.47 3696 646717 250561 62588048
Drug hypersensitivity 193.37 10.47 2142 648271 308545 62530064
Neutropenia 184.20 10.47 1045 649368 173960 62664649
Disease progression 176.26 10.47 654 649759 122104 62716505
Drug reaction with eosinophilia and systemic symptoms 174.57 10.47 64 650349 33772 62804837
Lactic acidosis 174.29 10.47 87 650326 38200 62800409
Therapeutic product effect decreased 171.22 10.47 2856 647557 190331 62648278
Sedation 171.00 10.47 92 650321 38717 62799892
Hyponatraemia 170.08 10.47 582 649831 111318 62727291
Hip arthroplasty 168.91 10.47 947 649466 46699 62791910
Knee arthroplasty 165.53 10.47 1036 649377 53170 62785439
Hypotension 163.85 10.47 1894 648519 270710 62567899
Bradycardia 161.98 10.47 315 650098 72912 62765697
Rhabdomyolysis 153.93 10.47 134 650279 43817 62794792
Cardio-respiratory arrest 153.57 10.47 235 650178 59724 62778885
Cardiac failure 145.61 10.47 449 649964 88693 62749916
Exposure during pregnancy 143.13 10.47 2314 648099 153233 62685376
Sopor 138.41 10.47 29 650384 22135 62816474
Drug intolerance 136.25 10.47 4132 646281 304529 62534080
Agitation 133.08 10.47 256 650157 59501 62779108
Rheumatic fever 128.55 10.47 819 649594 42292 62796317
Serotonin syndrome 127.83 10.47 67 650346 28615 62809994
Respiratory arrest 126.34 10.47 90 650323 32555 62806054
Tachycardia 126.19 10.47 702 649711 117454 62721155
Renal failure 124.02 10.47 702 649711 116950 62721659
Hypersensitivity 123.27 10.47 3896 646517 288789 62549820
Treatment failure 121.48 10.47 2781 647632 196262 62642347
Thrombocytopenia 121.34 10.47 978 649435 150179 62688430
Intentional self-injury 118.99 10.47 57 650356 25630 62812979
Metabolic acidosis 117.00 10.47 175 650238 44894 62793715
Hepatic failure 115.12 10.47 117 650296 35539 62803070
Red blood cell sedimentation rate abnormal 114.09 10.47 453 649960 19329 62819280
Impaired healing 112.76 10.47 1573 648840 100969 62737640
Swollen joint count increased 112.52 10.47 693 649720 35361 62803248
Coma 112.51 10.47 314 650099 64050 62774559
Vomiting 111.60 10.47 4644 645769 554973 62283636
Sickle cell anaemia with crisis 110.65 10.47 211 650202 5792 62832817
Multiple organ dysfunction syndrome 110.64 10.47 262 650151 56490 62782119
Hepatic function abnormal 108.80 10.47 132 650281 37010 62801599
Drug resistance 104.54 10.47 52 650361 22881 62815728
Sedation complication 102.51 10.47 11 650402 13811 62824798
Respiratory failure 101.90 10.47 618 649795 101240 62737369
Psoriasis 101.78 10.47 1349 649064 85608 62753001
Fibromyalgia 95.96 10.47 1252 649161 79168 62759441
Hypoglycaemia 95.64 10.47 306 650107 59759 62778850
Angioedema 93.84 10.47 221 650192 47744 62790865
Somnolence 93.57 10.47 1278 649135 177407 62661202
Arthritis 91.58 10.47 1683 648730 114238 62724371
Hepatocellular injury 90.52 10.47 88 650325 27293 62811316
Cholestasis 89.01 10.47 102 650311 29332 62809277
Blister 88.14 10.47 1842 648571 127972 62710637
Osteoarthritis 86.75 10.47 1416 648997 93927 62744682
Rash 86.28 10.47 6765 643648 554106 62284503
Folliculitis 86.12 10.47 1100 649313 69217 62769392
Anaphylactic reaction 85.43 10.47 367 650046 65733 62772876
Sleep disorder due to general medical condition, insomnia type 85.24 10.47 864 649549 51353 62787256
Cytomegalovirus infection 84.77 10.47 55 650358 20897 62817712
Peripheral swelling 84.51 10.47 3429 646984 262513 62576096
Hyperglycaemia 83.44 10.47 191 650222 41676 62796933
Seizure 83.31 10.47 912 649501 131722 62706887
Muscle injury 82.49 10.47 1028 649385 64317 62774292
No adverse event 82.43 10.47 189 650224 41216 62797393
Hyperhidrosis 82.30 10.47 707 649706 107129 62731480
Creatinine renal clearance decreased 82.20 10.47 32 650381 16276 62822333
Leukopenia 82.07 10.47 460 649953 76830 62761779
Device expulsion 81.84 10.47 145 650268 34777 62803832
Orthostatic hypotension 80.43 10.47 155 650258 36005 62802604
Anaemia 79.78 10.47 2342 648071 291088 62547521
Dyspnoea 79.77 10.47 5767 644646 655546 62183063
Renal impairment 79.27 10.47 554 649859 87801 62750808
Nausea 79.21 10.47 7610 642803 846861 61991748
Intentional product use issue 78.61 10.47 1789 648624 126103 62712506
Blood cholesterol increased 78.07 10.47 1376 649037 92656 62745953
Poisoning 75.76 10.47 23 650390 13677 62824932
Syncope 75.39 10.47 803 649610 116582 62722027
Hyperkalaemia 75.02 10.47 293 650120 53910 62784699
Irritable bowel syndrome 74.61 10.47 1223 649190 81189 62757420
Shock 74.60 10.47 78 650335 23385 62815224
Blood pressure fluctuation 74.47 10.47 764 649649 45553 62793056
Macular degeneration 74.22 10.47 84 650329 24292 62814317
Contusion 73.30 10.47 2035 648378 148009 62690600
Altered state of consciousness 72.49 10.47 91 650322 25139 62813470
Respiratory depression 72.36 10.47 25 650388 13690 62824919
Drug ineffective for unapproved indication 71.50 10.47 151 650262 33912 62804697
Hepatotoxicity 71.40 10.47 172 650241 36869 62801740
Constipation 71.39 10.47 1756 648657 223187 62615422
Metastases to bone 71.30 10.47 66 650347 20953 62817656
C-reactive protein abnormal 71.11 10.47 754 649659 45342 62793267
Cognitive disorder 70.85 10.47 312 650101 55503 62783106
Intentional product misuse 70.56 10.47 352 650061 60565 62778044
Sinusitis 69.82 10.47 2913 647500 223740 62614869
Product use in unapproved indication 69.78 10.47 1353 649060 177727 62660882
Encephalopathy 69.29 10.47 186 650227 38434 62800175
Drug withdrawal syndrome 69.22 10.47 107 650306 27087 62811522
Drug dependence 68.59 10.47 90 650323 24393 62814216
Lower respiratory tract infection 68.48 10.47 1808 648605 130499 62708110
Anaphylactic shock 67.11 10.47 86 650327 23547 62815062
Condition aggravated 66.84 10.47 4882 645531 397335 62441274
Carpal tunnel syndrome 66.77 10.47 403 650010 20414 62818195
Neoplasm progression 66.45 10.47 174 650239 36254 62802355
Osteonecrosis of jaw 65.43 10.47 166 650247 34957 62803652
Mydriasis 64.46 10.47 21 650392 11935 62826674
Palmar-plantar erythrodysaesthesia syndrome 64.08 10.47 85 650328 22930 62815679
Ejection fraction decreased 63.69 10.47 81 650332 22251 62816358
Blood glucose increased 63.51 10.47 550 649863 83206 62755403
Drug level increased 63.27 10.47 84 650329 22652 62815957
Hypoxia 62.85 10.47 357 650056 59435 62779174
Gamma-glutamyltransferase increased 61.73 10.47 163 650250 33868 62804741
Loss of personal independence in daily activities 61.68 10.47 1367 649046 95923 62742686
Acute hepatic failure 61.63 10.47 58 650355 18269 62820340
Blood creatine phosphokinase increased 61.31 10.47 138 650275 30292 62808317
Pregnancy 60.84 10.47 611 649802 36225 62802384
Ventricular tachycardia 60.66 10.47 69 650344 19910 62818699
Posterior reversible encephalopathy syndrome 60.59 10.47 53 650360 17292 62821317
Myelosuppression 60.59 10.47 93 650320 23610 62814999
Torsade de pointes 59.77 10.47 31 650382 13320 62825289
Myocardial infarction 59.52 10.47 695 649718 99198 62739411
Ejection fraction 59.18 10.47 96 650317 2310 62836299
Sensitisation 57.53 10.47 115 650298 3271 62835338
Cytokine release syndrome 57.33 10.47 38 650375 14276 62824333
Joint effusion 57.11 10.47 334 650079 16726 62821883
Cardiac failure congestive 57.07 10.47 638 649775 91795 62746814
Metastases to liver 56.44 10.47 97 650316 23542 62815067
Hypokalaemia 56.28 10.47 737 649676 103067 62735542
Myalgia 55.88 10.47 1111 649302 145418 62693191
Sepsis 55.72 10.47 1170 649243 151953 62686656
Neuroleptic malignant syndrome 55.46 10.47 27 650386 12029 62826580
Agranulocytosis 54.80 10.47 109 650304 25025 62813584
Neurotoxicity 54.56 10.47 56 650357 16934 62821675
Disseminated intravascular coagulation 54.44 10.47 69 650344 18982 62819627
Disability assessment scale score increased 53.97 10.47 109 650304 3124 62835485
Ascites 52.09 10.47 227 650186 40501 62798108
Basal cell carcinoma 52.02 10.47 476 649937 27515 62811094
Weight increased 51.88 10.47 3214 647199 257578 62581031
Hypothermia 51.82 10.47 38 650375 13543 62825066
Blood pressure systolic abnormal 50.74 10.47 271 650142 13115 62825494
Type 2 diabetes mellitus 50.31 10.47 927 649486 62941 62775668
Pyrexia 49.97 10.47 4145 646268 466333 62372276
Unresponsive to stimuli 49.92 10.47 178 650235 33638 62804971
Blood pressure diastolic abnormal 49.52 10.47 286 650127 14256 62824353
Blood alkaline phosphatase increased 49.34 10.47 249 650164 42718 62795891
Liver injury 48.94 10.47 882 649531 59638 62778971
Blood calcium decreased 48.51 10.47 126 650287 26325 62812284
Polycystic ovaries 48.33 10.47 127 650286 4344 62834265
Wrong technique in product usage process 48.32 10.47 407 650006 61933 62776676
Transplant rejection 48.30 10.47 25 650388 10755 62827854
Suicidal ideation 48.17 10.47 408 650005 62013 62776596
Thrombotic microangiopathy 48.06 10.47 24 650389 10537 62828072
Schizophrenia 47.78 10.47 21 650392 9931 62828678
Live birth 47.70 10.47 436 649977 25194 62813415
Akathisia 47.68 10.47 17 650396 9129 62829480
Blood bilirubin increased 46.89 10.47 208 650205 36932 62801677
Acute generalised exanthematous pustulosis 46.47 10.47 28 650385 11071 62827538
Osteoporosis 46.14 10.47 835 649578 56503 62782106
Respiratory distress 46.04 10.47 185 650228 33766 62804843
Abortion spontaneous 45.95 10.47 709 649704 46486 62792123
Accidental overdose 45.91 10.47 107 650306 23202 62815407
Polyneuropathy 45.82 10.47 49 650364 14540 62824069
Toxic skin eruption 45.46 10.47 39 650374 12846 62825763
Cerebral haemorrhage 45.20 10.47 162 650251 30567 62808042
Coagulopathy 44.87 10.47 89 650324 20455 62818154
Tremor 44.77 10.47 1022 649391 131217 62707392
Extrapyramidal disorder 44.72 10.47 42 650371 13242 62825367
Loss of consciousness 44.61 10.47 897 649516 117224 62721385
Neutrophil count decreased 44.28 10.47 367 650046 56039 62782570
Disorientation 43.97 10.47 231 650182 39221 62799388
Psychotic disorder 43.77 10.47 127 650286 25585 62813024
Injection site erythema 43.71 10.47 1139 649274 82035 62756574
International normalised ratio increased 43.67 10.47 287 650126 46138 62792471
Foot deformity 43.61 10.47 457 649956 27396 62811213
Blood pressure systolic increased 43.49 10.47 705 649708 46692 62791917
Respiratory disorder 43.46 10.47 229 650184 38853 62799756
Sinus tachycardia 43.44 10.47 117 650296 24151 62814458
Miosis 43.17 10.47 11 650402 7342 62831267
Red blood cell sedimentation rate increased 42.92 10.47 661 649752 43321 62795288
Parkinsonism 42.78 10.47 27 650386 10412 62828197
Status epilepticus 42.67 10.47 56 650357 15177 62823432
Proteinuria 42.63 10.47 82 650331 19063 62819546
Unintentional medical device removal 42.57 10.47 6 650407 6109 62832500
Juvenile idiopathic arthritis 41.74 10.47 100 650313 3226 62835383
Ill-defined disorder 41.65 10.47 1115 649298 80640 62757969
Cardiogenic shock 41.53 10.47 75 650338 17857 62820752
Grip strength decreased 41.41 10.47 379 650034 21908 62816701
Diabetic ketoacidosis 41.30 10.47 93 650320 20412 62818197
Accidental exposure to product 41.29 10.47 143 650270 27262 62811347
Jaundice 41.19 10.47 157 650256 29094 62809515
Dystonia 40.59 10.47 49 650364 13770 62824839
Urticaria 40.46 10.47 1342 649071 164460 62674149
Haemophagocytic lymphohistiocytosis 40.21 10.47 30 650383 10597 62828012
Pancreatitis acute 40.10 10.47 143 650270 27023 62811586
Heart rate decreased 40.07 10.47 673 649740 44887 62793722
Off label use 40.02 10.47 6183 644230 668279 62170330
Pain in extremity 39.88 10.47 3928 646485 327558 62511051
Joint laxity 39.86 10.47 82 650331 2382 62836227
Pleural effusion 39.79 10.47 693 649720 92517 62746092
Alanine aminotransferase increased 39.49 10.47 787 649626 102983 62735626
Stress cardiomyopathy 39.34 10.47 24 650389 9426 62829183
Inappropriate antidiuretic hormone secretion 39.20 10.47 61 650352 15401 62823208
Disturbance in attention 39.07 10.47 230 650183 37959 62800650
Metastases to central nervous system 38.99 10.47 46 650367 13059 62825550
Tumour lysis syndrome 38.60 10.47 22 650391 8968 62829641
Pulmonary embolism 38.60 10.47 905 649508 115779 62722830
Abnormal behaviour 38.58 10.47 103 650310 21323 62817286
Injection site reaction 38.57 10.47 827 649586 57697 62780912
Aspartate aminotransferase increased 38.28 10.47 672 649741 89605 62749004
Anxiety 37.71 10.47 1832 648581 215709 62622900
Exposure to toxic agent 37.71 10.47 6 650407 5581 62833028
Hallucination 37.64 10.47 369 650044 54448 62784161
Device difficult to use 36.92 10.47 46 650367 12750 62825859
Chest discomfort 36.91 10.47 851 649562 109118 62729491
Obstructive airways disorder 36.90 10.47 100 650313 20599 62818010
Arrhythmia 36.78 10.47 234 650179 37906 62800703
Asphyxia 36.77 10.47 9 650404 6172 62832437
Mania 36.17 10.47 44 650369 12323 62826286
Hypomania 36.16 10.47 10 650403 6320 62832289
Mental status changes 36.14 10.47 247 650166 39352 62799257
Haematotoxicity 36.08 10.47 26 650387 9350 62829259
Brain oedema 35.99 10.47 56 650357 14139 62824470
Diarrhoea 35.91 10.47 6619 643794 708747 62129862
Speech disorder 35.82 10.47 256 650157 40373 62798236
Stevens-Johnson syndrome 35.73 10.47 133 650280 24817 62813792
Oropharyngeal pain 35.63 10.47 1242 649171 93245 62745364
Myoclonus 35.30 10.47 68 650345 15800 62822809
Inflammation 35.28 10.47 1098 649315 81175 62757434
Injection site pruritus 35.24 10.47 654 649759 44462 62794147
Hypomagnesaemia 35.05 10.47 163 650250 28574 62810035
Ventricular fibrillation 34.94 10.47 42 650371 11825 62826784
Rash maculo-papular 34.85 10.47 188 650225 31708 62806901
Mucosal inflammation 34.75 10.47 310 650103 46618 62791991
Graft versus host disease 34.53 10.47 13 650400 6750 62831859
Bronchopulmonary aspergillosis 34.48 10.47 23 650390 8612 62829997
Haemoptysis 34.41 10.47 164 650249 28562 62810047
Toxic epidermal necrolysis 34.38 10.47 138 650275 25196 62813413
Joint destruction 34.32 10.47 141 650272 6111 62832498
Pulmonary fibrosis 33.90 10.47 585 649828 39224 62799385
Neck deformity 33.62 10.47 70 650343 2051 62836558
Face oedema 33.56 10.47 101 650312 20111 62818498
Bone marrow failure 33.48 10.47 170 650243 29120 62809489
Circulatory collapse 33.37 10.47 114 650299 21824 62816785
Caesarean section 32.85 10.47 292 650121 16740 62821869
Febrile bone marrow aplasia 32.80 10.47 17 650396 7308 62831301
Acute myeloid leukaemia 32.75 10.47 80 650333 17067 62821542
Bronchospasm 32.70 10.47 81 650332 17199 62821410
Temperature regulation disorder 32.66 10.47 11 650402 6121 62832488
Metastases to lung 32.61 10.47 50 650363 12700 62825909
Ischaemic stroke 32.58 10.47 86 650327 17871 62820738
Pulmonary arterial hypertension 32.56 10.47 120 650293 22457 62816152
Withdrawal syndrome 32.44 10.47 101 650312 19896 62818713
Delirium 32.32 10.47 346 650067 50195 62788414
Blood creatinine increased 32.29 10.47 670 649743 87174 62751435
Pulmonary oedema 31.82 10.47 384 650029 54489 62784120
Gastroenteritis viral 31.70 10.47 377 650036 23323 62815286
Asthenia 31.40 10.47 3445 646968 380159 62458450
Anuria 31.36 10.47 50 650363 12501 62826108
Breast cancer stage I 30.83 10.47 16 650397 6873 62831736
Substance abuse 30.62 10.47 6 650407 4801 62833808
Melaena 30.47 10.47 184 650229 30181 62808428
Restlessness 30.33 10.47 177 650236 29276 62809333
Hepatic cytolysis 30.12 10.47 71 650342 15336 62823273
Aggression 30.03 10.47 131 650282 23367 62815242
Ventricular septal defect 30.03 10.47 106 650307 4272 62834337
Blood pressure diastolic decreased 29.85 10.47 360 650053 22346 62816263
Bone erosion 29.80 10.47 295 650118 17422 62821187
Tachypnoea 29.79 10.47 85 650328 17217 62821392
Polyarthritis 29.77 10.47 192 650221 9954 62828655
Product administration error 29.77 10.47 123 650290 22274 62816335
Product quality issue 29.70 10.47 230 650183 35635 62802974
Device use error 29.54 10.47 11 650402 5750 62832859
Acute graft versus host disease 29.34 10.47 5 650408 4423 62834186
Disability 29.18 10.47 302 650111 18045 62820564
Aspergillus infection 29.16 10.47 24 650389 8069 62830540
Multiple fractures 29.03 10.47 169 650244 8449 62830160
Stomatitis 28.92 10.47 1717 648696 137008 62701601
Injection site swelling 28.75 10.47 664 649749 46908 62791701
Pain in jaw 28.53 10.47 296 650117 43200 62795409
Pathogen resistance 28.43 10.47 15 650398 6383 62832226
Gastrointestinal haemorrhage 28.42 10.47 624 649789 80552 62758057
Cerebral infarction 28.27 10.47 137 650276 23756 62814853
Joint range of motion decreased 28.14 10.47 478 649935 31950 62806659
Skin cancer 28.10 10.47 208 650205 11287 62827322
Forced expiratory volume decreased 28.09 10.47 8 650405 4960 62833649
Multiple-drug resistance 28.01 10.47 9 650404 5161 62833448
Haemorrhage 27.90 10.47 448 649965 60574 62778035
Erythema multiforme 27.86 10.47 38 650375 10131 62828478
Injection site bruising 27.54 10.47 592 649821 41318 62797291
Fear 27.48 10.47 77 650336 15689 62822920
Pancreatitis 27.42 10.47 346 650067 48709 62789900
Nasal polyps 27.07 10.47 14 650399 6025 62832584
Therapy partial responder 27.06 10.47 42 650371 10616 62827993
Drug tolerance decreased 27.03 10.47 286 650127 17187 62821422
Blood pressure decreased 26.93 10.47 486 649927 64536 62774073
Cardiotoxicity 26.88 10.47 28 650385 8410 62830199
Wheelchair user 26.79 10.47 132 650281 6187 62832422
Acute respiratory distress syndrome 26.67 10.47 137 650276 23397 62815212
Chronic kidney disease 26.59 10.47 317 650096 45081 62793528
Gestational diabetes 26.58 10.47 162 650251 8234 62830375
Disease recurrence 26.50 10.47 173 650240 27857 62810752
Infective pulmonary exacerbation of cystic fibrosis 26.18 10.47 31 650382 8786 62829823
Localised infection 26.11 10.47 445 649968 29765 62808844
Atrial fibrillation 25.92 10.47 955 649458 115681 62722928
Enthesopathy 25.89 10.47 164 650249 8450 62830159
Colitis 25.76 10.47 346 650067 48182 62790427
Coronary artery disease 25.71 10.47 210 650203 32167 62806442
Atrioventricular block complete 25.59 10.47 28 650385 8223 62830386
Palpitations 25.59 10.47 921 649492 111849 62726760
Eosinophilia 25.49 10.47 133 650280 22623 62815986
Laryngitis 25.45 10.47 276 650137 16691 62821918
Intestinal stenosis 25.35 10.47 76 650337 2808 62835801
Purpura 25.14 10.47 49 650364 11336 62827273
Tardive dyskinesia 25.13 10.47 30 650383 8472 62830137
Dizziness 24.89 10.47 3946 646467 425979 62412630
Platelet count decreased 24.87 10.47 955 649458 115167 62723442
Paradoxical drug reaction 24.79 10.47 6 650407 4146 62834463
Bradyphrenia 24.78 10.47 21 650392 6959 62831650
Adverse event 24.22 10.47 883 649530 66676 62771933
Nephrectomy 24.18 10.47 50 650363 1458 62837151
Pseudomonas infection 24.13 10.47 49 650364 11164 62827445
Dehydration 23.90 10.47 1493 648920 171861 62666748
Transplant dysfunction 23.84 10.47 10 650403 4862 62833747
Haemorrhage intracranial 23.79 10.47 65 650348 13354 62825255
Septic shock 23.66 10.47 511 649902 66118 62772491
Schizoaffective disorder 23.65 10.47 4 650409 3558 62835051
Irritability 23.63 10.47 209 650204 31485 62807124
Ankylosing spondylitis 23.63 10.47 186 650227 10288 62828321
Tuberculosis 23.61 10.47 196 650217 11015 62827594
Fluid retention 23.51 10.47 450 649963 59236 62779373
Premature labour 23.41 10.47 213 650200 12291 62826318
Injection site pain 23.30 10.47 1586 648827 128214 62710395
Nodule 23.27 10.47 323 650090 20703 62817906
Femur fracture 23.16 10.47 576 649837 41180 62797429
Graft versus host disease in gastrointestinal tract 22.99 10.47 3 650410 3238 62835371
Neck mass 22.82 10.47 85 650328 3518 62835091
Interstitial lung disease 22.80 10.47 472 649941 61436 62777173
Pemphigoid 22.69 10.47 25 650388 7319 62831290
Cytomegalovirus viraemia 22.62 10.47 15 650398 5634 62832975
Rash erythematous 22.60 10.47 303 650110 42207 62796402
Maternal drugs affecting foetus 22.58 10.47 110 650303 5132 62833477
Acidosis 22.58 10.47 51 650362 11182 62827427
Leukocytosis 22.57 10.47 164 650249 25771 62812838
Muscle twitching 22.57 10.47 114 650299 19554 62819055
Jaundice cholestatic 22.56 10.47 25 650388 7299 62831310
Myopathy 22.34 10.47 51 650362 11140 62827469
Device related infection 22.30 10.47 144 650269 23248 62815361
Cytopenia 22.25 10.47 54 650359 11547 62827062
Dyskinesia 22.15 10.47 215 650198 31787 62806822
Rheumatoid nodule 22.12 10.47 271 650142 16884 62821725
Prescribed underdose 22.03 10.47 427 649986 29262 62809347
Tenderness 21.90 10.47 339 650074 22239 62816370
Cardiomyopathy 21.88 10.47 99 650314 17485 62821124
Pulseless electrical activity 21.74 10.47 27 650386 7494 62831115
Cholecystitis chronic 21.68 10.47 46 650367 10315 62828294
Haematoma 21.61 10.47 240 650173 34580 62804029
Joint stiffness 21.59 10.47 572 649841 41297 62797312
Hypocalcaemia 21.55 10.47 214 650199 31499 62807110
Genital haemorrhage 21.53 10.47 26 650387 7306 62831303
Second primary malignancy 21.50 10.47 30 650383 7923 62830686
Bradypnoea 21.45 10.47 5 650408 3545 62835064
Hyperbilirubinaemia 21.44 10.47 53 650360 11261 62827348
Ketoacidosis 21.40 10.47 9 650404 4369 62834240
Diabetes mellitus 21.30 10.47 423 649990 55387 62783222
Acute respiratory failure 21.28 10.47 238 650175 34247 62804362
Cyanosis 21.28 10.47 95 650318 16840 62821769
Infection 21.25 10.47 2670 647743 226503 62612106
Sexual dysfunction 21.24 10.47 9 650404 4350 62834259
Body temperature decreased 21.23 10.47 309 650104 20010 62818599
C-reactive protein increased 21.23 10.47 1180 649233 93527 62745082
Skin papilloma 21.21 10.47 104 650309 4865 62833744
Transaminases increased 21.18 10.47 212 650201 31155 62807454
Acute coronary syndrome 21.16 10.47 45 650368 10081 62828528
Vision blurred 21.02 10.47 750 649663 91174 62747435
Product administered to patient of inappropriate age 20.98 10.47 4 650409 3264 62835345
Procedural pain 20.96 10.47 132 650281 21437 62817172
Complication associated with device 20.88 10.47 96 650317 16882 62821727
Toxic encephalopathy 20.77 10.47 22 650391 6557 62832052
Hyperprolactinaemia 20.76 10.47 7 650406 3893 62834716
Synovial cyst 20.71 10.47 180 650233 10253 62828356
Hepatitis cholestatic 20.62 10.47 24 650389 6854 62831755
Hyperthermia 20.58 10.47 39 650374 9117 62829492
Nightmare 20.49 10.47 114 650299 19080 62819529
Deep vein thrombosis 20.49 10.47 678 649735 83122 62755487
Hallucinations, mixed 20.47 10.47 12 650401 4817 62833792
Paranoia 20.38 10.47 57 650356 11622 62826987
Hepatitis acute 20.36 10.47 39 650374 9081 62829528
Pulmonary hypertension 20.32 10.47 263 650150 36860 62801749
Spinal stenosis 20.22 10.47 238 650175 14687 62823922
Decreased appetite 20.19 10.47 2257 648156 248795 62589814
Adjustment disorder 20.15 10.47 75 650338 3103 62835506
Labelled drug-drug interaction medication error 20.13 10.47 70 650343 13329 62825280
Myocardial ischaemia 20.12 10.47 66 650347 12793 62825816
Acute myocardial infarction 20.11 10.47 221 650192 31903 62806706
Blood pressure diastolic increased 20.02 10.47 173 650240 9837 62828772
Maternal exposure before pregnancy 19.98 10.47 140 650273 7463 62831146
Subarachnoid haemorrhage 19.89 10.47 77 650336 14206 62824403
Hepatitis B reactivation 19.80 10.47 4 650409 3133 62835476
Bone pain 19.71 10.47 418 649995 54223 62784386
Joint dislocation 19.69 10.47 286 650127 18514 62820095
Klebsiella infection 19.68 10.47 36 650377 8530 62830079
Renal injury 19.68 10.47 42 650371 9397 62829212
Swollen tongue 19.62 10.47 245 650168 34555 62804054
Malignant melanoma 19.54 10.47 190 650223 11166 62827443
Dysphagia 19.53 10.47 726 649687 87859 62750750
Epilepsy 19.51 10.47 180 650233 26885 62811724
Pulmonary haemorrhage 19.50 10.47 27 650386 7154 62831455
Epstein-Barr virus infection 19.25 10.47 33 650380 8017 62830592
Latent tuberculosis 19.23 10.47 65 650348 2562 62836047
Emotional distress 19.17 10.47 227 650186 32322 62806287
Sleep disorder due to a general medical condition 19.09 10.47 200 650213 11988 62826621
Pharyngitis streptococcal 19.08 10.47 180 650233 10492 62828117
Haemodynamic instability 19.07 10.47 41 650372 9149 62829460
Red blood cell count decreased 18.91 10.47 548 649865 40097 62798512
Wrong product administered 18.87 10.47 21 650392 6120 62832489
Injection site rash 18.86 10.47 284 650129 18525 62820084
Atrial tachycardia 18.75 10.47 10 650403 4230 62834379
Malignant mediastinal neoplasm 18.72 10.47 44 650369 1402 62837207
Dermatitis exfoliative 18.68 10.47 17 650396 5442 62833167
Electrocardiogram QRS complex prolonged 18.59 10.47 20 650393 5918 62832691
Vertigo 18.56 10.47 469 649944 59418 62779191
Insomnia 18.53 10.47 1926 648487 213326 62625283
Respiratory acidosis 18.49 10.47 25 650388 6690 62831919
Treatment noncompliance 18.43 10.47 270 650143 37055 62801554
Hyperlipidaemia 18.40 10.47 121 650292 19450 62819159
Colitis microscopic 18.29 10.47 43 650370 9296 62829313
Smear cervix abnormal 18.24 10.47 69 650344 2877 62835732
Tubulointerstitial nephritis 18.23 10.47 124 650289 19779 62818830
Drug-induced liver injury 18.15 10.47 296 650117 39926 62798683
Acute pulmonary oedema 18.11 10.47 35 650378 8123 62830486
Metastases to lymph nodes 18.11 10.47 35 650378 8123 62830486
Right aortic arch 18.09 10.47 17 650396 227 62838382
Sinus bradycardia 18.06 10.47 82 650331 14469 62824140
Limb deformity 17.98 10.47 85 650328 3917 62834692
Psychomotor hyperactivity 17.91 10.47 53 650360 10610 62827999
Musculoskeletal pain 17.90 10.47 1135 649278 91142 62747467
Pulmonary alveolar haemorrhage 17.89 10.47 13 650400 4655 62833954
Small for dates baby 17.83 10.47 81 650332 3670 62834939
Hypertransaminasaemia 17.80 10.47 25 650388 6584 62832025
Hallucination, visual 17.79 10.47 120 650293 19178 62819431
Abortion incomplete 17.78 10.47 5 650408 3126 62835483
Foetal exposure during pregnancy 17.76 10.47 441 649972 31521 62807088
Graft versus host disease in skin 17.73 10.47 4 650409 2901 62835708
Drug use disorder 17.69 10.47 15 650398 4969 62833640
Paraesthesia oral 17.62 10.47 120 650293 19136 62819473
Reversible cerebral vasoconstriction syndrome 17.61 10.47 3 650410 2655 62835954
Rotator cuff repair 17.61 10.47 55 650358 2079 62836530
Influenza 17.53 10.47 1317 649096 107405 62731204
Chronic graft versus host disease 17.53 10.47 5 650408 3097 62835512
Neutropenic colitis 17.47 10.47 5 650408 3090 62835519
Hypernatraemia 17.46 10.47 32 650381 7577 62831032
Chronic sinusitis 17.40 10.47 70 650343 12773 62825836
Diabetes insipidus 17.31 10.47 3 650410 2622 62835987
Blood test abnormal 17.26 10.47 240 650173 15389 62823220
Angina pectoris 17.24 10.47 211 650202 29867 62808742
Poor venous access 17.13 10.47 229 650184 14556 62824053
Metastases to meninges 17.10 10.47 3 650410 2599 62836010
Neurologic neglect syndrome 17.07 10.47 64 650349 2657 62835952
Body temperature increased 17.01 10.47 273 650140 36919 62801690
Tenosynovitis stenosans 17.01 10.47 74 650339 3290 62835319
Clostridium difficile colitis 16.98 10.47 132 650281 20437 62818172
Skin toxicity 16.96 10.47 14 650399 4700 62833909
Developmental hip dysplasia 16.95 10.47 41 650372 1331 62837278
Pallor 16.94 10.47 216 650197 30352 62808257
Carotid artery thrombosis 16.94 10.47 65 650348 2729 62835880
Dyspnoea exertional 16.92 10.47 479 649934 59823 62778786
Burning sensation 16.88 10.47 700 649713 53707 62784902
Hypoglycaemic coma 16.86 10.47 3 650410 2572 62836037
Disturbance in social behaviour 16.82 10.47 10 650403 3983 62834626
Pregnancy with contraceptive device 16.81 10.47 14 650399 4680 62833929
Atrioventricular block 16.81 10.47 33 650380 7614 62830995
Aspiration 16.77 10.47 56 650357 10795 62827814
Skin ulcer 16.77 10.47 568 649845 42477 62796132
Muscle rigidity 16.66 10.47 61 650352 11439 62827170
Renal tubular necrosis 16.56 10.47 64 650349 11814 62826795
Cerebrovascular accident 16.55 10.47 921 649492 107103 62731506
Placental disorder 16.54 10.47 43 650370 1461 62837148
Product substitution issue 16.54 10.47 96 650317 15900 62822709
Glycosylated haemoglobin increased 16.53 10.47 68 650345 12330 62826279
Peripheral sensory neuropathy 16.51 10.47 32 650381 7419 62831190
Catatonia 16.48 10.47 13 650400 4464 62834145
Adenovirus infection 16.42 10.47 8 650405 3563 62835046
Immune reconstitution inflammatory syndrome 16.40 10.47 23 650390 6061 62832548
Pre-eclampsia 16.31 10.47 154 650259 8979 62829630
Proctitis 16.29 10.47 19 650394 5422 62833187
Premature rupture of membranes 16.23 10.47 97 650316 4896 62833713
Erythema 16.16 10.47 1565 648848 174186 62664423
Myocarditis 16.15 10.47 53 650360 10272 62828337
Lupus-like syndrome 16.14 10.47 233 650180 15062 62823547
Blood lactate dehydrogenase increased 16.12 10.47 155 650258 22961 62815648
Dysmorphism 16.10 10.47 56 650357 2240 62836369
Atrial septal defect 16.09 10.47 124 650289 6814 62831795
Ileus 15.97 10.47 87 650326 14638 62823971
Tendonitis 15.90 10.47 286 650127 19329 62819280
Hepatic necrosis 15.83 10.47 21 650392 5666 62832943
Left ventricular dysfunction 15.83 10.47 66 650347 11922 62826687
Urinary retention 15.73 10.47 217 650196 30084 62808525
Pulmonary congestion 15.72 10.47 109 650304 17309 62821300
Ear infection 15.59 10.47 507 649906 37706 62800903
Intervertebral disc degeneration 15.56 10.47 237 650176 15495 62823114
Panic attack 15.46 10.47 150 650263 22181 62816428
Mobility decreased 15.46 10.47 1442 648971 119717 62718892
Paralysis 15.36 10.47 51 650362 9849 62828760
Haematemesis 15.36 10.47 219 650194 30193 62808416
Uterine perforation 15.35 10.47 30 650383 6933 62831676
Shock haemorrhagic 15.34 10.47 51 650362 9844 62828765
Synovial disorder 15.33 10.47 51 650362 1994 62836615
Acute chest syndrome 15.31 10.47 29 650384 792 62837817
Neuropathy peripheral 15.30 10.47 981 649432 112686 62725923
Chronic disease 15.28 10.47 13 650400 151 62838458
Dermatitis bullous 15.24 10.47 41 650372 8467 62830142
Lethargy 15.18 10.47 447 649966 55560 62783049
Arthritis infective 15.15 10.47 116 650297 6362 62832247
Bone lesion 15.10 10.47 23 650390 5858 62832751
Bundle branch block left 15.06 10.47 31 650382 7028 62831581
Generalised tonic-clonic seizure 14.99 10.47 208 650205 28808 62809801
Blood pressure increased 14.99 10.47 1888 648525 160174 62678435
Cyst 14.97 10.47 215 650198 13884 62824725
Peripheral venous disease 14.87 10.47 232 650181 15245 62823364
Surgery 14.79 10.47 477 649936 35435 62803174
Hyperuricaemia 14.78 10.47 20 650393 5350 62833259
Oliguria 14.74 10.47 46 650367 9055 62829554
Bronchial secretion retention 14.72 10.47 5 650408 2768 62835841
Foetal anticonvulsant syndrome 14.69 10.47 24 650389 581 62838028
Intestinal resection 14.67 10.47 63 650350 2785 62835824
Balance disorder 14.60 10.47 711 649702 83711 62754898
Gastrointestinal disorder 14.57 10.47 1547 648866 129692 62708917
Asthma 14.53 10.47 1117 649296 126444 62712165
Rhinorrhoea 14.49 10.47 816 649597 64761 62773848
Rebound effect 14.44 10.47 15 650398 4511 62834098
Systemic inflammatory response syndrome 14.42 10.47 22 650391 5599 62833010
Loose body in joint 14.38 10.47 37 650376 1249 62837360
Drug abuser 14.30 10.47 6 650407 2917 62835692
Generalised oedema 14.27 10.47 99 650314 15719 62822890
Synovial fluid analysis 14.26 10.47 56 650357 2377 62836232
Wound infection 14.25 10.47 303 650110 21107 62817502
Body height below normal 14.24 10.47 52 650361 2131 62836478
Compartment syndrome 14.24 10.47 3 650410 2281 62836328
Breast cancer female 14.22 10.47 81 650332 13478 62825131
Vitamin B12 deficiency 14.14 10.47 98 650315 5205 62833404
Hepatitis fulminant 14.14 10.47 9 650404 3455 62835154
Facet joint syndrome 14.06 10.47 188 650225 11950 62826659
Obesity 13.98 10.47 404 650009 29548 62809061
Pericardial effusion 13.96 10.47 220 650193 29838 62808771
Retinitis 13.96 10.47 110 650303 6086 62832523
Polyuria 13.96 10.47 43 650370 8499 62830110
Purging 13.93 10.47 8 650405 46 62838563
Stress 13.92 10.47 831 649582 66336 62772273
Cystitis haemorrhagic 13.92 10.47 13 650400 4110 62834499
Nephropathy toxic 13.92 10.47 50 650363 9429 62829180
Polyhydramnios 13.90 10.47 53 650360 2218 62836391
Hyperammonaemia 13.88 10.47 20 650393 5212 62833397
Clear cell renal cell carcinoma 13.88 10.47 40 650373 1445 62837164
Intracranial pressure increased 13.85 10.47 20 650393 5207 62833402
Pulmonary toxicity 13.80 10.47 50 650363 9405 62829204
Hallucination, auditory 13.78 10.47 76 650337 12748 62825861
Pruritus genital 13.72 10.47 5 650408 2649 62835960
Red blood cell sedimentation rate 13.72 10.47 91 650322 4763 62833846
Squamous cell carcinoma 13.69 10.47 142 650271 8490 62830119
Blood lactic acid increased 13.58 10.47 33 650380 7053 62831556
Congenital arterial malformation 13.55 10.47 17 650396 320 62838289
Cardiac failure acute 13.48 10.47 51 650362 9472 62829137
Hepatocellular carcinoma 13.44 10.47 3 650410 2191 62836418
Rectal abscess 13.42 10.47 36 650377 1247 62837362
Postoperative wound infection 13.41 10.47 171 650242 10754 62827855
Chest pain 13.38 10.47 1974 648439 213985 62624624
Visual acuity reduced 13.32 10.47 151 650262 21675 62816934
Activated partial thromboplastin time prolonged 13.29 10.47 32 650381 6861 62831748
Exostosis 13.28 10.47 257 650156 17605 62821004
Benign neoplasm of adrenal gland 13.28 10.47 7 650406 33 62838576
Antibody test positive 13.28 10.47 59 650354 2648 62835961
Subdural haematoma 13.26 10.47 89 650324 14239 62824370
Lip swelling 13.23 10.47 231 650182 30832 62807777
Cerebral haematoma 13.17 10.47 11 650402 3672 62834937
Anticholinergic syndrome 13.17 10.47 4 650409 2378 62836231
Blood iron decreased 13.14 10.47 218 650195 14503 62824106
Affective disorder 13.10 10.47 27 650386 6119 62832490
Breast feeding 13.08 10.47 28 650385 837 62837772
Inadequate analgesia 12.93 10.47 7 650406 2936 62835673
Colorectal cancer 12.90 10.47 11 650402 3634 62834975
Rectal haemorrhage 12.87 10.47 393 650020 48637 62789972
Immunosuppressant drug level increased 12.85 10.47 11 650402 3627 62834982
Cartilage injury 12.82 10.47 47 650366 1930 62836679
Hyperpyrexia 12.80 10.47 11 650402 3621 62834988
Lymphoedema 12.72 10.47 69 650344 11623 62826986
Metabolic surgery 12.68 10.47 35 650378 1233 62837376
Catheter site pain 12.66 10.47 18 650395 4717 62833892
Hypoalbuminaemia 12.66 10.47 70 650343 11735 62826874
Therapeutic reaction time decreased 12.66 10.47 53 650360 2317 62836292
Copper deficiency 12.61 10.47 9 650404 79 62838530
Right ventricular failure 12.52 10.47 114 650299 17074 62821535
Diabetes mellitus inadequate control 12.52 10.47 97 650316 15029 62823580
Scleritis 12.51 10.47 83 650330 4345 62834264
Discoloured vomit 12.45 10.47 28 650385 866 62837743
Complication of device removal 12.37 10.47 21 650392 5121 62833488
Bone density abnormal 12.34 10.47 68 650345 3330 62835279
Polydipsia 12.32 10.47 11 650402 3553 62835056
Dislocation of vertebra 12.28 10.47 139 650274 8496 62830113
Blood urea increased 12.28 10.47 193 650220 26186 62812423
Osteonecrosis 12.27 10.47 177 650236 24353 62814256
Faecal calprotectin increased 12.25 10.47 65 650348 3138 62835471
Potentiating drug interaction 12.21 10.47 16 650397 4340 62834269
Tenosynovitis 12.21 10.47 204 650209 13591 62825018
Laryngospasm 12.18 10.47 8 650405 3020 62835589
Product complaint 12.14 10.47 79 650334 12730 62825879
Ejection fraction abnormal 12.05 10.47 43 650370 1742 62836867
Rheumatoid lung 12.03 10.47 74 650339 3774 62834835
Product prescribing error 12.01 10.47 193 650220 26096 62812513
Neoplasm recurrence 12.00 10.47 6 650407 2632 62835977
Loss of employment 11.99 10.47 4 650409 2240 62836369
Middle insomnia 11.97 10.47 78 650335 12565 62826044
Foot operation 11.96 10.47 120 650293 7111 62831498
Depression 11.95 10.47 1798 648615 194694 62643915
Gastrointestinal toxicity 11.93 10.47 40 650373 7701 62830908
Maternal exposure timing unspecified 11.92 10.47 118 650295 6969 62831640
Metabolic disorder 11.91 10.47 31 650382 6472 62832137
Staphylococcal sepsis 11.85 10.47 43 650370 8085 62830524
Enterocolitis 11.84 10.47 41 650372 7817 62830792
Bacteraemia 11.81 10.47 117 650296 17231 62821378
Progressive multifocal leukoencephalopathy 11.79 10.47 81 650332 12890 62825719
Haemoglobin decreased 11.72 10.47 1681 648732 143804 62694805
Cytomegalovirus infection reactivation 11.69 10.47 14 650399 3949 62834660
Kidney transplant rejection 11.66 10.47 16 650397 4255 62834354
Soft tissue disorder 11.64 10.47 17 650396 4405 62834204
Drug screen positive 11.61 10.47 12 650401 3617 62834992
Myringotomy 11.60 10.47 6 650407 27 62838582
Anti-cyclic citrullinated peptide antibody 11.60 10.47 113 650300 6645 62831964
Aplasia 11.58 10.47 16 650397 4243 62834366
Weight decreased 11.57 10.47 3095 647318 273703 62564906
Hypervolaemia 11.56 10.47 213 650200 28200 62810409
Eosinophilic granulomatosis with polyangiitis 11.56 10.47 4 650409 2188 62836421
Flushing 11.53 10.47 640 649773 74447 62764162
Nocardiosis 11.52 10.47 3 650410 1973 62836636
Lymphopenia 11.50 10.47 126 650287 18201 62820408
Crohn's disease 11.50 10.47 88 650325 4825 62833784
Breast cancer metastatic 11.45 10.47 74 650339 11944 62826665
Metastases to peritoneum 11.45 10.47 11 650402 3431 62835178
Rhinovirus infection 11.35 10.47 18 650395 4511 62834098
Muscle spasticity 11.34 10.47 156 650257 21638 62816971
Human antichimeric antibody positive 11.33 10.47 41 650372 1673 62836936
Hypophagia 11.31 10.47 239 650174 31020 62807589
Fracture delayed union 11.29 10.47 52 650361 2370 62836239
Device deployment issue 11.29 10.47 14 650399 3888 62834721
Foot fracture 11.28 10.47 323 650090 23591 62815018
Hyperthyroidism 11.27 10.47 96 650317 14577 62824032
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.21 10.47 8 650405 2891 62835718
Tonsillar inflammation 11.19 10.47 9 650404 96 62838513
Brain injury 11.12 10.47 36 650377 7007 62831602
Incorrect route of product administration 11.11 10.47 206 650207 27246 62811363
Complication of device insertion 11.04 10.47 40 650373 7524 62831085
Lymph gland infection 11.03 10.47 19 650394 481 62838128
Device dislocation 11.00 10.47 191 650222 25514 62813095
Sleep apnoea syndrome 10.99 10.47 383 650030 28750 62809859
Lip dry 10.97 10.47 221 650192 15249 62823360
Therapeutic response decreased 10.90 10.47 751 649662 60774 62777835
Total lung capacity increased 10.89 10.47 5 650408 2305 62836304
Sleep terror 10.89 10.47 7 650406 2673 62835936
Blood phosphorus decreased 10.88 10.47 18 650395 4435 62834174
Full blood count decreased 10.80 10.47 346 650067 25678 62812931
Epstein-Barr virus associated lymphoproliferative disorder 10.80 10.47 3 650410 1891 62836718
Ventricular arrhythmia 10.80 10.47 14 650399 3814 62834795
Tick-borne fever 10.77 10.47 3 650410 0 62838609
Myringitis 10.77 10.47 3 650410 0 62838609
Red blood cell count 10.77 10.47 3 650410 0 62838609
Alcoholic seizure 10.77 10.47 3 650410 0 62838609
Vasa praevia 10.77 10.47 3 650410 0 62838609
Ligamentitis 10.77 10.47 3 650410 0 62838609
Shigella infection 10.77 10.47 3 650410 0 62838609
Personality change 10.77 10.47 36 650377 6937 62831672
Haemodialysis 10.76 10.47 51 650362 8896 62829713
Heparin-induced thrombocytopenia 10.76 10.47 19 650394 4563 62834046
Autism spectrum disorder 10.75 10.47 26 650387 844 62837765
International normalised ratio fluctuation 10.73 10.47 6 650407 2472 62836137
Catheter site erythema 10.72 10.47 17 650396 4259 62834350
Hydrocephalus 10.70 10.47 24 650389 5276 62833333
Anaemia vitamin B12 deficiency 10.69 10.47 17 650396 402 62838207
Laryngeal oedema 10.67 10.47 27 650386 5691 62832918
Oedema peripheral 10.65 10.47 1742 648671 187769 62650840
Hypercapnia 10.64 10.47 25 650388 5406 62833203
Bundle branch block right 10.62 10.47 22 650391 4976 62833633
Neutrophilia 10.59 10.47 18 650395 4388 62834221
Gastroschisis 10.57 10.47 17 650396 406 62838203
Eye infection 10.53 10.47 179 650234 11966 62826643
Abdominal pain 10.51 10.47 2759 647654 290697 62547912
Hepatic encephalopathy 10.48 10.47 70 650343 11212 62827397

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 485.55 10.64 53 237137 99043 34620698
Rheumatoid arthritis 445.30 10.64 872 236318 37366 34682375
Toxicity to various agents 434.06 10.64 432 236758 199930 34519811
Completed suicide 386.76 10.64 95 237095 98073 34621668
Drug interaction 294.54 10.64 689 236501 225257 34494484
Arthralgia 238.60 10.64 1969 235221 168072 34551669
Foetal exposure during pregnancy 190.87 10.64 631 236559 37470 34682271
Psoriatic arthropathy 148.56 10.64 379 236811 19419 34700322
Intentional overdose 137.46 10.64 62 237128 43612 34676129
Acute kidney injury 134.56 10.64 1372 235818 303616 34416125
Joint swelling 116.85 10.64 751 236439 59139 34660602
Fatigue 114.15 10.64 3305 233885 367348 34352393
Sickle cell anaemia with crisis 113.74 10.64 139 237051 3914 34715827
Overdose 111.79 10.64 286 236904 90773 34628968
Coma 108.75 10.64 90 237100 45588 34674153
Dysmorphism 103.11 10.64 117 237073 3039 34716702
Product use in unapproved indication 102.68 10.64 429 236761 117070 34602671
Drug reaction with eosinophilia and systemic symptoms 96.12 10.64 52 237138 32960 34686781
Blood pressure fluctuation 94.93 10.64 381 236809 24868 34694873
Psoriasis 94.56 10.64 516 236674 38296 34681445
Multiple organ dysfunction syndrome 90.52 10.64 245 236945 76321 34643420
Rhabdomyolysis 90.03 10.64 206 236984 67957 34651784
Pain 87.40 10.64 1908 235282 202767 34516974
Musculoskeletal stiffness 85.35 10.64 576 236614 46104 34673637
Suicide attempt 77.07 10.64 91 237099 39025 34680716
Enthesopathy 76.65 10.64 123 237067 4490 34715251
Serotonin syndrome 75.16 10.64 21 237169 19912 34699829
Peripheral swelling 70.88 10.64 813 236377 75728 34644013
Drug dependence 70.71 10.64 38 237152 24179 34695562
Febrile neutropenia 67.64 10.64 598 236592 136251 34583490
Nasopharyngitis 65.60 10.64 745 236445 69223 34650518
Blood pressure systolic increased 65.53 10.64 319 236871 22633 34697108
Fall 65.19 10.64 1820 235370 201065 34518676
Intentional product misuse 63.38 10.64 134 237056 45477 34674264
Weight decreased 63.07 10.64 1604 235586 174697 34545044
Hepatic function abnormal 61.09 10.64 131 237059 44232 34675509
Blood pressure increased 59.80 10.64 884 236306 87218 34632523
Speech disorder developmental 59.40 10.64 74 237116 2126 34717615
Premature baby 59.04 10.64 277 236913 19356 34700385
Sopor 58.10 10.64 7 237183 12129 34707612
Cytomegalovirus infection 57.98 10.64 55 237135 26080 34693661
Respiratory arrest 56.58 10.64 64 237126 27979 34691762
Bradycardia 56.57 10.64 291 236899 75127 34644614
Tenosynovitis 56.55 10.64 107 237083 4463 34715278
Cardiac arrest 55.90 10.64 402 236788 95757 34623984
Arthritis 55.62 10.64 384 236806 30962 34688779
Exposure during pregnancy 54.96 10.64 159 237031 8775 34710966
Pain in extremity 54.73 10.64 1182 236008 125331 34594410
Drug resistance 54.71 10.64 57 237133 25870 34693871
Arthropathy 54.66 10.64 341 236849 26566 34693175
Synovitis 53.46 10.64 213 236977 13853 34705888
Heart rate decreased 50.61 10.64 379 236811 31366 34688375
Foetal anticonvulsant syndrome 49.35 10.64 50 237140 1137 34718604
Altered state of consciousness 48.68 10.64 50 237140 22843 34696898
Renal failure 48.43 10.64 610 236580 129947 34589794
Respiratory failure 47.84 10.64 488 236702 108084 34611657
Angioedema 47.69 10.64 115 237075 37259 34682482
Toxic epidermal necrolysis 47.49 10.64 46 237144 21600 34698141
C-reactive protein abnormal 46.98 10.64 148 237042 8562 34711179
Haemoglobin decreased 46.49 10.64 1110 236080 119662 34600079
Depressed level of consciousness 46.29 10.64 143 237047 42698 34677043
Neonatal respiratory distress syndrome 45.70 10.64 91 237099 3943 34715798
Osteoarthritis 45.36 10.64 267 236923 20375 34699366
Off label use 45.25 10.64 2357 234833 417167 34302574
Maternal exposure during pregnancy 44.23 10.64 101 237089 4817 34714924
Appendicolith 43.64 10.64 4 237186 8597 34711144
Sedation 43.41 10.64 47 237143 20959 34698782
Poisoning 42.31 10.64 15 237175 12211 34707530
Atrial septal defect 42.09 10.64 128 237062 7264 34712477
Alanine aminotransferase abnormal 41.86 10.64 96 237094 4592 34715149
Hypospadias 40.92 10.64 76 237114 3125 34716616
Cardiac failure 40.65 10.64 409 236781 90839 34628902
Learning disorder 40.06 10.64 43 237147 1048 34718693
Suicidal ideation 40.05 10.64 140 237050 40248 34679493
Lactic acidosis 39.05 10.64 114 237076 34658 34685083
Hepatic failure 38.93 10.64 113 237077 34418 34685323
Cryptorchism 38.92 10.64 58 237132 1983 34717758
Blood pressure systolic abnormal 38.80 10.64 84 237106 3864 34715877
Maternal drugs affecting foetus 38.55 10.64 84 237106 3881 34715860
Agitation 38.38 10.64 230 236960 57169 34662572
Acute hepatic failure 38.36 10.64 24 237166 14050 34705691
Autism spectrum disorder 37.85 10.64 61 237129 2235 34717506
Pathogen resistance 37.64 10.64 9 237181 9473 34710268
Basal cell carcinoma 37.38 10.64 245 236945 19413 34700328
Small for dates baby 36.83 10.64 82 237108 3845 34715896
Renal impairment 36.38 10.64 438 236752 94075 34625666
Hypoglycaemia neonatal 36.22 10.64 54 237136 1847 34717894
Skin cancer 36.03 10.64 152 237038 10145 34709596
Somnolence 35.86 10.64 534 236656 110582 34609159
Delirium 35.72 10.64 165 237025 43826 34675915
Maternal exposure during breast feeding 35.61 10.64 48 237142 1493 34718248
Respiratory depression 35.09 10.64 35 237155 16210 34703531
Psychotic disorder 34.67 10.64 71 237119 24381 34695360
Disease progression 34.67 10.64 520 236670 107557 34612184
Full blood count decreased 34.13 10.64 225 236965 17863 34701878
Drug withdrawal syndrome 34.11 10.64 51 237139 19783 34699958
Rheumatoid nodule 34.01 10.64 67 237123 2880 34716861
Blood pressure diastolic decreased 33.99 10.64 137 237053 8957 34710784
Ventricular fibrillation 33.97 10.64 65 237125 22889 34696852
Asthenia 33.57 10.64 2008 235182 243243 34476498
Low birth weight baby 33.57 10.64 124 237066 7781 34711960
Cardiogenic shock 33.10 10.64 83 237107 26535 34693206
Syndactyly 32.93 10.64 35 237155 843 34718898
Hypoglycaemia 32.92 10.64 226 236964 54414 34665327
Substance abuse 32.91 10.64 6 237184 7635 34712106
Gait disturbance 32.89 10.64 783 236407 84357 34635384
Ventricular septal defect 32.54 10.64 79 237111 3922 34715819
Vitamin B12 deficiency 32.15 10.64 79 237111 3952 34715789
Palmar-plantar erythrodysaesthesia syndrome 32.09 10.64 40 237150 16755 34702986
Musculoskeletal pain 32.07 10.64 345 236845 31618 34688123
Tongue disorder 31.86 10.64 94 237096 5245 34714496
Blood pressure diastolic abnormal 31.84 10.64 88 237102 4730 34715011
Rash maculo-papular 31.42 10.64 94 237096 28357 34691384
Shock 31.16 10.64 74 237116 24105 34695636
Ankylosing spondylitis 30.94 10.64 96 237094 5508 34714233
Pyrexia 30.54 10.64 1900 235290 331113 34388628
Back pain 30.41 10.64 1060 236130 120729 34599012
Immune reconstitution inflammatory syndrome 29.88 10.64 11 237179 8748 34710993
Hyperglycaemia 29.78 10.64 152 237038 39328 34680413
Developmental delay 29.54 10.64 61 237129 2714 34717027
Grip strength decreased 29.53 10.64 66 237124 3103 34716638
Electrocardiogram QT prolonged 29.03 10.64 161 237029 40791 34678950
Venoocclusive liver disease 28.92 10.64 9 237181 7957 34711784
Body temperature decreased 28.90 10.64 169 237021 12865 34706876
Finger deformity 28.86 10.64 43 237147 1470 34718271
Cataract 28.80 10.64 288 236902 25898 34693843
Cardio-respiratory arrest 28.39 10.64 239 236951 55034 34664707
Anaphylactic shock 28.38 10.64 40 237150 15901 34703840
Joint laxity 28.27 10.64 23 237167 389 34719352
Metabolic acidosis 28.17 10.64 177 237013 43503 34676238
Neck pain 27.98 10.64 279 236911 25070 34694671
Back disorder 27.96 10.64 104 237086 6547 34713194
Joint effusion 27.79 10.64 88 237102 5105 34714636
Talipes 27.57 10.64 48 237142 1875 34717866
Drug intolerance 27.49 10.64 562 236628 59008 34660733
Product dose omission issue 27.46 10.64 1032 236158 118679 34601062
Hyperbilirubinaemia neonatal 27.28 10.64 30 237160 752 34718989
Foot deformity 27.19 10.64 80 237110 4457 34715284
Poor venous access 26.98 10.64 87 237103 5096 34714645
Aspergillus infection 26.93 10.64 26 237164 12228 34707513
Neurotoxicity 26.65 10.64 51 237139 17959 34701782
Hand deformity 26.59 10.64 70 237120 3655 34716086
Influenza 26.47 10.64 479 236711 49187 34670554
Abdominal discomfort 26.46 10.64 561 236629 59274 34660467
Joint range of motion decreased 26.41 10.64 109 237081 7203 34712538
Hypermobility syndrome 26.37 10.64 21 237169 344 34719397
Death 26.26 10.64 2335 234855 395714 34324027
Infusion related reaction 25.96 10.64 505 236685 52552 34667189
Malignant neoplasm progression 25.75 10.64 431 236759 87615 34632126
Proteinuria 25.70 10.64 55 237135 18587 34701154
Knee arthroplasty 25.36 10.64 109 237081 7335 34712406
Localised infection 25.27 10.64 205 236985 17382 34702359
Acute respiratory distress syndrome 25.09 10.64 91 237099 25878 34693863
Vomiting 24.94 10.64 1400 235790 246221 34473520
Anal fistula 24.89 10.64 87 237103 5312 34714429
Exposure via breast milk 24.79 10.64 47 237143 1963 34717778
Tachycardia 24.78 10.64 415 236775 84357 34635384
Incorrect route of product administration 24.73 10.64 39 237151 14806 34704935
Congenital hand malformation 24.62 10.64 25 237165 570 34719171
Wound 24.56 10.64 179 237011 14685 34705056
Plagiocephaly 24.47 10.64 24 237166 524 34719217
Cholestasis 24.37 10.64 97 237093 26851 34692890
Disseminated intravascular coagulation 24.15 10.64 72 237118 21744 34697997
Sinusitis 24.11 10.64 405 236785 40997 34678744
Pulmonary fibrosis 24.08 10.64 210 236980 18186 34701555
Intentional self-injury 24.08 10.64 35 237155 13736 34706005
Stevens-Johnson syndrome 24.05 10.64 57 237133 18582 34701159
Jaundice neonatal 23.90 10.64 37 237153 1309 34718432
Drug ineffective 23.59 10.64 2727 234463 454024 34265717
Astigmatism 23.59 10.64 33 237157 1064 34718677
Ear infection 23.56 10.64 134 237056 10097 34709644
Hypoaesthesia 23.39 10.64 564 236626 60880 34658861
Agranulocytosis 23.33 10.64 83 237107 23738 34696003
Akathisia 23.27 10.64 13 237177 8096 34711645
Tendonitis 23.25 10.64 123 237067 9017 34710724
Colitis ulcerative 22.90 10.64 191 236999 16329 34703412
Dysgraphia 22.86 10.64 49 237141 2238 34717503
Hepatocellular injury 22.69 10.64 76 237114 22135 34697606
Intellectual disability 22.67 10.64 36 237154 1302 34718439
Plasma cell myeloma 22.60 10.64 406 236784 41631 34678110
Nasal disorder 22.45 10.64 44 237146 1884 34717857
Ascites 22.31 10.64 205 236985 46366 34673375
Urinary tract infection 22.28 10.64 737 236453 83344 34636397
Suspected suicide 22.10 10.64 3 237187 4745 34714996
Vitamin D deficiency 21.93 10.64 96 237094 6512 34713229
Haemangioma congenital 21.87 10.64 22 237168 496 34719245
Gamma-glutamyltransferase increased 21.78 10.64 113 237077 29118 34690623
Red blood cell sedimentation rate increased 21.76 10.64 121 237069 9041 34710700
Drug level increased 21.63 10.64 77 237113 22019 34697722
Nephrolithiasis 21.60 10.64 307 236883 30026 34689715
Caesarean section 21.21 10.64 46 237144 2118 34717623
Language disorder 21.04 10.64 47 237143 2209 34717532
Acute chest syndrome 21.03 10.64 27 237163 800 34718941
Appendicitis 20.98 10.64 43 237147 14764 34704977
Blood creatine phosphokinase increased 20.83 10.64 199 236991 44658 34675083
Acute graft versus host disease 20.82 10.64 9 237181 6494 34713247
Ventricular tachycardia 20.80 10.64 101 237089 26478 34693263
Electrocardiogram QRS complex prolonged 20.74 10.64 4 237186 4890 34714851
Ultrasound antenatal screen 20.57 10.64 22 237168 534 34719207
Thrombocytopenia 20.51 10.64 859 236331 155388 34564353
Joint stiffness 20.36 10.64 135 237055 10738 34709003
Large for dates baby 20.31 10.64 28 237162 890 34718851
Transplant rejection 20.29 10.64 24 237166 10287 34709454
Congenital oesophageal anomaly 20.22 10.64 11 237179 90 34719651
Hydrops foetalis 20.03 10.64 27 237163 840 34718901
Frequent bowel movements 20.00 10.64 152 237038 12635 34707106
Neuroleptic malignant syndrome 19.98 10.64 59 237131 17875 34701866
Blood test abnormal 19.97 10.64 97 237093 6874 34712867
Diaphragmatic disorder 19.83 10.64 33 237157 1242 34718499
Osteonecrosis of jaw 19.83 10.64 59 237131 17830 34701911
Blood pressure diastolic increased 19.83 10.64 77 237113 4948 34714793
Drug ineffective for unapproved indication 19.81 10.64 88 237102 23627 34696114
Post procedural infection 19.64 10.64 75 237115 4781 34714960
Contusion 19.47 10.64 351 236839 36013 34683728
Therapy partial responder 19.33 10.64 22 237168 9594 34710147
Arthritis infective 19.28 10.64 59 237131 3360 34716381
Dyspraxia 19.26 10.64 19 237171 418 34719323
Balance disorder 19.23 10.64 385 236805 40269 34679472
Haematochezia 19.20 10.64 432 236758 46102 34673639
Cerebral haemorrhage 18.88 10.64 149 237041 34788 34684953
Intestinal stenosis 18.68 10.64 44 237146 2142 34717599
Septic shock 18.67 10.64 359 236831 71475 34648266
Throat lesion 18.46 10.64 13 237177 175 34719566
Aggression 18.46 10.64 172 237018 38792 34680949
Faecal calprotectin increased 18.35 10.64 48 237142 2496 34717245
Spinal disorder 18.31 10.64 67 237123 4185 34715556
Hyperkalaemia 18.27 10.64 346 236844 69043 34650698
Polyarthritis 18.27 10.64 70 237120 4470 34715271
Lower respiratory tract infection 18.24 10.64 309 236881 31328 34688413
Second primary malignancy 18.20 10.64 16 237174 7870 34711871
Brain oedema 18.05 10.64 42 237148 13779 34705962
Intercepted product preparation error 18.01 10.64 3 237187 4075 34715666
Cystitis haemorrhagic 17.96 10.64 8 237182 5671 34714070
Kyphosis 17.92 10.64 31 237159 1205 34718536
Acute generalised exanthematous pustulosis 17.86 10.64 12 237178 6764 34712977
Ear disorder 17.81 10.64 37 237153 1653 34718088
Neck mass 17.81 10.64 36 237154 1577 34718164
Trisomy 18 17.79 10.64 24 237166 747 34718994
Oropharyngeal pain 17.78 10.64 339 236851 35146 34684595
Vitamin D decreased 17.78 10.64 58 237132 3418 34716323
Skin injury 17.70 10.64 45 237145 2300 34717441
Thrombotic microangiopathy 17.64 10.64 28 237162 10602 34709139
Pulmonary alveolar haemorrhage 17.63 10.64 15 237175 7497 34712244
Knee deformity 17.29 10.64 22 237168 646 34719095
Motor developmental delay 17.29 10.64 22 237168 646 34719095
Hypotonia neonatal 17.27 10.64 32 237158 1313 34718428
Adenovirus infection 17.27 10.64 7 237183 5250 34714491
Haematocrit decreased 17.26 10.64 311 236879 31905 34687836
Pneumonia 17.26 10.64 2756 234434 359871 34359870
Vitamin B12 decreased 17.25 10.64 31 237159 1242 34718499
Hyperammonaemia 17.16 10.64 11 237179 6356 34713385
Foetal growth restriction 16.99 10.64 64 237126 4053 34715688
Acute graft versus host disease in skin 16.97 10.64 7 237183 5194 34714547
Dysstasia 16.90 10.64 141 237049 12054 34707687
Medical device implantation 16.81 10.64 21 237169 605 34719136
Infection 16.77 10.64 766 236424 90149 34629592
Weight increased 16.77 10.64 782 236408 92251 34627490
BK virus infection 16.75 10.64 9 237181 5729 34714012
Cellulitis 16.66 10.64 474 236716 52477 34667264
Otitis media 16.60 10.64 50 237140 2822 34716919
Hepatic encephalopathy 16.59 10.64 48 237142 14637 34705104
Pancytopenia 16.54 10.64 797 236393 94360 34625381
Selective eating disorder 16.53 10.64 37 237153 1741 34718000
Heart rate irregular 16.50 10.64 172 237018 15635 34704106
Anal fissure 16.33 10.64 65 237125 4225 34715516
No adverse event 16.32 10.64 90 237100 22837 34696904
Cardiotoxicity 16.29 10.64 9 237181 5639 34714102
Radiation inflammation 16.24 10.64 25 237165 880 34718861
Colorectal cancer 16.21 10.64 6 237184 4755 34714986
Pancreatitis acute 16.16 10.64 118 237072 28023 34691718
Withdrawal syndrome 16.14 10.64 38 237152 12417 34707324
Kidney infection 16.14 10.64 76 237114 5318 34714423
Gastrointestinal infection 16.13 10.64 80 237110 5718 34714023
Cleft lip and palate 16.10 10.64 25 237165 887 34718854
Cytomegalovirus viraemia 16.05 10.64 16 237174 7414 34712327
Eosinophilia 16.02 10.64 108 237082 26114 34693627
Maternal exposure before pregnancy 15.84 10.64 23 237167 768 34718973
Saliva altered 15.84 10.64 12 237178 182 34719559
Posterior reversible encephalopathy syndrome 15.79 10.64 27 237163 9927 34709814
Hypotension 15.78 10.64 1292 235898 220357 34499384
Bronchopulmonary aspergillosis 15.78 10.64 49 237141 14610 34705131
Chronic graft versus host disease 15.77 10.64 5 237185 4368 34715373
Haemophagocytic lymphohistiocytosis 15.70 10.64 41 237149 12932 34706809
Red blood cell count decreased 15.65 10.64 281 236909 28809 34690932
Cytokine release syndrome 15.64 10.64 91 237099 22786 34696955
Dyslexia 15.62 10.64 15 237175 319 34719422
Exposure to toxic agent 15.58 10.64 3 237187 3672 34716069
Hip fracture 15.54 10.64 136 237054 11789 34707952
Lacrimal disorder 15.54 10.64 15 237175 321 34719420
Sexual dysfunction 15.52 10.64 12 237178 6291 34713450
Congenital foot malformation 15.49 10.64 17 237173 425 34719316
Malignant melanoma 15.48 10.64 101 237089 7989 34711752
Nephrotic syndrome 15.47 10.64 16 237174 7287 34712454
Headache 15.47 10.64 1571 235619 199064 34520677
Infective pulmonary exacerbation of cystic fibrosis 15.45 10.64 14 237176 6787 34712954
Pneumonia aspiration 15.43 10.64 196 236994 41707 34678034
Hypokalaemia 15.41 10.64 290 236900 57924 34661817
Limb reduction defect 15.40 10.64 14 237176 277 34719464
Multiple congenital abnormalities 15.27 10.64 19 237171 545 34719196
Foetal disorder 15.08 10.64 23 237167 803 34718938
Strabismus 14.96 10.64 35 237155 1696 34718045
Mania 14.90 10.64 26 237164 9485 34710256
Umbilical hernia 14.81 10.64 67 237123 4610 34715131
Drug withdrawal syndrome neonatal 14.73 10.64 56 237134 3563 34716178
Intestinal resection 14.72 10.64 35 237155 1714 34718027
Fistula 14.72 10.64 88 237102 6752 34712989
Seizure 14.71 10.64 572 236618 104285 34615456
Immunodeficiency 14.69 10.64 75 237115 5423 34714318
Hydrocele 14.67 10.64 39 237151 2048 34717693
Low set ears 14.67 10.64 17 237173 452 34719289
Loss of personal independence in daily activities 14.64 10.64 311 236879 32868 34686873
C-reactive protein increased 14.53 10.64 475 236715 53623 34666118
Attention deficit hyperactivity disorder 14.28 10.64 44 237146 2515 34717226
Hypertriglyceridaemia 14.26 10.64 22 237168 8426 34711315
Small intestinal obstruction 14.23 10.64 159 237031 14707 34705034
Haematotoxicity 14.15 10.64 21 237169 8173 34711568
Rheumatoid lung 14.15 10.64 24 237166 918 34718823
Progressive multifocal leukoencephalopathy 14.14 10.64 28 237162 9736 34710005
Hypoxia 14.11 10.64 276 236914 54819 34664922
Mydriasis 14.07 10.64 17 237173 7220 34712521
Blood iron decreased 13.86 10.64 72 237118 5241 34714500
Central nervous system inflammation 13.86 10.64 12 237178 222 34719519
Myasthenia gravis 13.82 10.64 16 237174 6924 34712817
Complications of transplanted kidney 13.80 10.64 7 237183 4602 34715139
Congenital bladder anomaly 13.78 10.64 13 237177 270 34719471
Dermatitis acneiform 13.75 10.64 13 237177 6176 34713565
Red blood cell sedimentation rate 13.70 10.64 27 237163 1161 34718580
Status epilepticus 13.69 10.64 42 237148 12572 34707169
Accessory spleen 13.69 10.64 10 237180 143 34719598
Hyponatraemia 13.67 10.64 442 236748 82249 34637492
Cleft lip 13.66 10.64 14 237176 323 34719418
Weight decrease neonatal 13.59 10.64 14 237176 325 34719416
Bradycardia neonatal 13.53 10.64 24 237166 952 34718789
Pectus excavatum 13.51 10.64 12 237178 230 34719511
Irritability 13.48 10.64 105 237085 24585 34695156
Increased tendency to bruise 13.48 10.64 59 237131 4002 34715739
Nocardiosis 13.41 10.64 5 237185 3946 34715795
Hernia 13.39 10.64 111 237079 9472 34710269
Polyhydramnios 13.38 10.64 12 237178 233 34719508
Injection site pain 13.35 10.64 353 236837 38652 34681089
Dystonia 13.34 10.64 34 237156 10811 34708930
Hypertelorism 13.25 10.64 18 237172 564 34719177
Miosis 13.25 10.64 28 237162 9507 34710234
Ankyloglossia congenital 13.25 10.64 13 237177 284 34719457
Extrapyramidal disorder 13.20 10.64 44 237146 12836 34706905
Inguinal hernia 13.19 10.64 93 237097 7548 34712193
Obsessive-compulsive disorder 13.19 10.64 11 237179 5553 34714188
Arthritis bacterial 13.19 10.64 69 237121 5037 34714704
Tubulointerstitial nephritis 13.14 10.64 86 237104 20938 34698803
Ileal stenosis 13.13 10.64 29 237161 1352 34718389
Cytomegalovirus chorioretinitis 13.13 10.64 4 237186 3585 34716156
Drug use disorder 13.10 10.64 6 237184 4185 34715556
Hepatitis fulminant 13.10 10.64 6 237184 4184 34715557
Inappropriate schedule of product administration 13.08 10.64 532 236658 61764 34657977
Respiratory disorder neonatal 13.06 10.64 32 237158 1598 34718143
Wrong technique in product usage process 13.00 10.64 169 237021 35817 34683924
Hypothermia 12.99 10.64 34 237156 10714 34709027
Peripheral coldness 12.96 10.64 89 237101 7162 34712579
Disinhibition 12.93 10.64 3 237187 3223 34716518
Nephropathy toxic 12.91 10.64 43 237147 12545 34707196
Blood insulin increased 12.89 10.64 14 237176 346 34719395
Blood parathyroid hormone decreased 12.88 10.64 30 237160 1450 34718291
Potentiating drug interaction 12.87 10.64 9 237181 4968 34714773
Scoliosis 12.87 10.64 45 237145 2748 34716993
Hepatotoxicity 12.87 10.64 89 237101 21396 34698345
Laboratory test abnormal 12.81 10.64 202 236988 20189 34699552
Klebsiella infection 12.76 10.64 24 237166 8507 34711234
Agitation neonatal 12.75 10.64 25 237165 1071 34718670
Inflammation 12.73 10.64 266 236924 28029 34691712
Tumour lysis syndrome 12.68 10.64 66 237124 16993 34702748
Cerebral infarction 12.66 10.64 122 237068 27333 34692408
Akinesia 12.60 10.64 38 237152 2146 34717595
Tinea pedis 12.49 10.64 30 237160 1479 34718262
Abdominal adhesions 12.44 10.64 30 237160 1483 34718258
Pernicious anaemia 12.42 10.64 8 237182 92 34719649
Gait apraxia 12.38 10.64 4 237186 6 34719735
Erythema multiforme 12.36 10.64 25 237165 8624 34711117
Granuloma skin 12.32 10.64 27 237163 1252 34718489
Latent tuberculosis 12.27 10.64 28 237162 1335 34718406
Diabetic ketoacidosis 12.18 10.64 72 237118 17960 34701781
Renal aplasia 12.15 10.64 20 237170 746 34718995
Pulmonary haemorrhage 12.14 10.64 33 237157 10271 34709470
Polydactyly 12.14 10.64 26 237164 1187 34718554
Urine odour abnormal 12.04 10.64 26 237164 1194 34718547
Fear 12.01 10.64 34 237156 10442 34709299
Central cord syndrome 12.00 10.64 3 237187 0 34719741
Heat oedema 12.00 10.64 3 237187 0 34719741
Diarrhoea 11.99 10.64 2900 234290 387012 34332729
Oesophageal fibrosis 11.96 10.64 10 237180 176 34719565
Serum ferritin increased 11.93 10.64 77 237113 6069 34713672
Skin abrasion 11.92 10.64 86 237104 7033 34712708
Mobility decreased 11.90 10.64 278 236912 29850 34689891
Neutropenia 11.90 10.64 909 236281 155869 34563872
Juvenile idiopathic arthritis 11.90 10.64 34 237156 1863 34717878
Synovial cyst 11.89 10.64 39 237151 2305 34717436
Congenital anomaly 11.86 10.64 28 237162 1365 34718376
Catatonia 11.83 10.64 10 237180 5015 34714726
Abscess intestinal 11.82 10.64 31 237159 1615 34718126
Septic arthritis staphylococcal 11.81 10.64 16 237174 500 34719241
Tuberculosis 11.80 10.64 99 237091 8478 34711263
Therapeutic product effect decreased 11.77 10.64 314 236876 34429 34685312
Osteomyelitis 11.76 10.64 164 237026 15972 34703769
Tooth malformation 11.73 10.64 10 237180 181 34719560
C-reactive protein decreased 11.71 10.64 35 237155 1967 34717774
Hepatitis B 11.69 10.64 14 237176 5969 34713772
Mouth ulceration 11.69 10.64 128 237062 11782 34707959
Abortion spontaneous 11.68 10.64 14 237176 386 34719355
Crohn's disease 11.68 10.64 47 237143 3070 34716671
Pneumatosis intestinalis 11.68 10.64 6 237184 3917 34715824
Multiple-drug resistance 11.65 10.64 11 237179 5228 34714513
Renal injury 11.64 10.64 38 237152 11157 34708584
Vitamin B complex deficiency 11.63 10.64 14 237176 388 34719353
Arthrodesis 11.62 10.64 15 237175 447 34719294
Hernia pain 11.56 10.64 12 237178 281 34719460
Gallbladder disorder 11.52 10.64 80 237110 6462 34713279
Therapeutic reaction time decreased 11.43 10.64 26 237164 1237 34718504
Cardiac flutter 11.42 10.64 33 237157 1820 34717921
Rash pruritic 11.39 10.64 251 236939 26690 34693051
Chest expansion decreased 11.37 10.64 9 237181 146 34719595
Loss of consciousness 11.36 10.64 452 236738 82215 34637526
Sinus congestion 11.36 10.64 71 237119 5534 34714207
Vascular insufficiency 11.36 10.64 13 237177 341 34719400
Arnold-Chiari malformation 11.36 10.64 13 237177 341 34719400
Asphyxia 11.34 10.64 18 237172 6817 34712924
Microcephaly 11.31 10.64 20 237170 791 34718950
On and off phenomenon 11.31 10.64 40 237150 2457 34717284
Blood phosphorus increased 11.30 10.64 22 237168 7699 34712042
Developmental coordination disorder 11.29 10.64 10 237180 191 34719550
Cholelithiasis 11.28 10.64 204 236986 20944 34698797
Interstitial lung disease 11.26 10.64 347 236843 64935 34654806
Cerebral microangiopathy 11.24 10.64 10 237180 192 34719549
Vascular stent thrombosis 11.24 10.64 3 237187 2932 34716809
Diabetes insipidus 11.20 10.64 3 237187 2925 34716816
Hospice care 11.14 10.64 83 237107 6857 34712884
Vitamin B6 deficiency 11.12 10.64 10 237180 195 34719546
Behaviour disorder 11.10 10.64 64 237126 4846 34714895
Cardiac failure chronic 11.06 10.64 23 237167 7856 34711885
Autoscopy 11.00 10.64 11 237179 246 34719495
Endophthalmitis 11.00 10.64 5 237185 3503 34716238
Product quality issue 10.99 10.64 69 237121 16966 34702775
Upper respiratory tract infection 10.97 10.64 298 236892 32761 34686980
Pleural fibrosis 10.96 10.64 27 237163 1353 34718388
Encephalopathy 10.94 10.64 171 237019 35148 34684593
Hyperthermia 10.93 10.64 36 237154 10541 34709200
Toxic skin eruption 10.93 10.64 40 237150 11345 34708396
Pseudomonas infection 10.92 10.64 45 237145 12337 34707404
Graft versus host disease 10.91 10.64 36 237154 10533 34709208
Urticaria 10.89 10.64 331 236859 62046 34657695
Cyst 10.88 10.64 60 237130 4468 34715273
Cholangitis 10.87 10.64 27 237163 8662 34711079
Leukopenia 10.86 10.64 334 236856 62522 34657219
Glycosylated haemoglobin increased 10.84 10.64 40 237150 11320 34708421
Dry throat 10.80 10.64 39 237151 2420 34717321
Abdominal hernia 10.79 10.64 42 237148 2702 34717039
Acoustic neuroma 10.74 10.64 9 237181 159 34719582
Folate deficiency 10.72 10.64 25 237165 1209 34718532
Hallucination, auditory 10.71 10.64 43 237147 11874 34707867
Muscle twitching 10.68 10.64 35 237155 10263 34709478
Joint ankylosis 10.67 10.64 29 237161 1543 34718198
Stoma site inflammation 10.67 10.64 15 237175 486 34719255
Hepatitis E antibody positive 10.65 10.64 11 237179 256 34719485

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1470.97 10.15 181 678701 245586 78819920
Toxicity to various agents 1312 10.15 1003 677879 420537 78644969
Drug abuse 990.03 10.15 113 678769 162578 78902928
Rheumatoid arthritis 937.58 10.15 3886 674996 204584 78860922
Drug interaction 754.51 10.15 1497 677385 413686 78651820
Arthropathy 690.95 10.15 3164 675718 173947 78891559
Pemphigus 656.54 10.15 2103 676779 97479 78968027
Joint swelling 656.41 10.15 4456 674426 284190 78781316
Arthralgia 653.76 10.15 7588 671294 564215 78501291
Systemic lupus erythematosus 647.10 10.15 2385 676497 118764 78946742
Hand deformity 627.34 10.15 2130 676752 101789 78963717
Synovitis 604.39 10.15 2715 676167 148019 78917487
Glossodynia 573.50 10.15 2060 676822 101277 78964229
Pain 479.09 10.15 8529 670353 695273 78370233
Abdominal discomfort 477.78 10.15 3711 675171 247016 78818490
Anti-cyclic citrullinated peptide antibody positive 473.74 10.15 1672 677210 81471 78984035
Wound 470.39 10.15 2099 676783 114080 78951426
Intentional overdose 450.42 10.15 169 678713 105791 78959715
Infusion related reaction 437.64 10.15 3406 675476 226831 78838675
Maternal exposure during pregnancy 430.90 10.15 2297 676585 134241 78931265
Alopecia 419.15 10.15 3385 675497 227970 78837536
Pericarditis 417.27 10.15 1877 677005 102359 78963147
Acute kidney injury 409.18 10.15 2666 676216 516738 78548768
Nasopharyngitis 407.84 10.15 3616 675266 250265 78815241
Discomfort 368.59 10.15 2072 676810 123545 78941961
Overdose 350.78 10.15 645 678237 183561 78881945
Swelling 349.69 10.15 3090 675792 213621 78851885
Musculoskeletal stiffness 337.39 10.15 2598 676284 172410 78893096
Febrile neutropenia 335.68 10.15 937 677945 230062 78835444
Therapeutic product effect decreased 328.47 10.15 2455 676427 161408 78904098
Cardiac arrest 314.17 10.15 618 678264 171478 78894028
Rheumatoid factor positive 291.23 10.15 1144 677738 58695 79006811
Psoriatic arthropathy 290.98 10.15 1376 677506 76623 78988883
Duodenal ulcer perforation 287.54 10.15 1222 677660 64989 79000517
Fatigue 287.41 10.15 10127 668755 919600 78145906
Helicobacter infection 286.28 10.15 1265 677617 68439 78997067
Suicide attempt 269.46 10.15 188 678694 82744 78982762
Drug reaction with eosinophilia and systemic symptoms 267.14 10.15 106 678776 64138 79001368
Death 266.34 10.15 3316 675566 563198 78502308
Contraindicated product administered 257.47 10.15 2253 676629 155285 78910221
Peripheral swelling 253.83 10.15 3454 675428 266163 78799343
Depressed level of consciousness 253.30 10.15 269 678613 96383 78969123
Rhabdomyolysis 251.80 10.15 304 678578 102827 78962679
Hepatic enzyme increased 235.37 10.15 2484 676398 180126 78885380
Sinusitis 231.10 10.15 2614 676268 192887 78872619
Multiple organ dysfunction syndrome 223.59 10.15 427 678455 119819 78945687
Drug intolerance 217.32 10.15 3305 675577 260814 78804692
Bradycardia 208.80 10.15 534 678348 135023 78930483
Impaired healing 200.39 10.15 1356 677526 86299 78979207
Blood pressure fluctuation 196.49 10.15 1107 677775 66038 78999468
Lactic acidosis 195.58 10.15 186 678696 70173 78995333
Respiratory arrest 194.29 10.15 125 678757 57425 79008081
Coma 193.67 10.15 350 678532 100299 78965207
Arthritis 193.42 10.15 1654 677228 113226 78952280
Sedation 191.83 10.15 101 678781 51794 79013712
Exposure during pregnancy 187.40 10.15 1488 677394 99644 78965862
Renal failure 184.65 10.15 981 677901 199987 78865519
Serotonin syndrome 184.42 10.15 76 678806 44951 79020555
Cardio-respiratory arrest 183.37 10.15 407 678475 108103 78957403
Hepatic function abnormal 182.19 10.15 212 678670 72895 78992611
Sopor 175.26 10.15 34 678848 32976 79032530
Weight increased 173.90 10.15 3322 675560 274064 78791442
Drug resistance 173.29 10.15 71 678811 42142 79023364
Respiratory failure 168.48 10.15 879 678003 180032 78885474
Sickle cell anaemia with crisis 167.86 10.15 267 678615 7655 79057851
Osteoarthritis 167.48 10.15 1295 677587 86014 78979492
Electrocardiogram QT prolonged 166.24 10.15 323 678559 90063 78975443
Malignant neoplasm progression 165.56 10.15 597 678285 135393 78930113
Cardiac failure 165.47 10.15 716 678166 154126 78911380
Neutropenia 159.74 10.15 1621 677261 286089 78779417
Cytomegalovirus infection 159.10 10.15 82 678800 42562 79022944
Irritable bowel syndrome 157.60 10.15 988 677894 61253 79004253
C-reactive protein abnormal 157.44 10.15 821 678061 47546 79017960
Hyponatraemia 156.84 10.15 880 678002 176968 78888538
Lower respiratory tract infection 156.80 10.15 1737 677145 127483 78938023
Hypotension 153.40 10.15 2731 676151 437586 78627920
Muscle injury 151.71 10.15 815 678067 47746 79017760
Hypersensitivity 151.38 10.15 3102 675780 259137 78806369
Red blood cell sedimentation rate abnormal 151.24 10.15 457 678425 20506 79045000
Fibromyalgia 151.05 10.15 1002 677880 63338 79002168
Hepatic failure 150.92 10.15 179 678703 61033 79004473
Knee arthroplasty 149.08 10.15 746 678136 42502 79023004
Folliculitis 147.08 10.15 890 677992 54490 79011016
Product use issue 146.56 10.15 2556 676326 207266 78858240
Agitation 146.56 10.15 402 678480 99313 78966193
Sleep disorder due to general medical condition, insomnia type 145.01 10.15 744 678138 42812 79022694
Blister 144.03 10.15 1604 677278 117872 78947634
Contusion 143.97 10.15 1916 676966 146860 78918646
Psoriasis 140.49 10.15 1270 677612 88317 78977189
Product use in unapproved indication 138.35 10.15 1412 677470 248947 78816559
Pain in extremity 137.65 10.15 4070 674812 360468 78705038
Disease progression 137.37 10.15 961 677921 183401 78882105
Renal impairment 136.80 10.15 785 678097 156998 78908508
Thrombocytopenia 136.51 10.15 1521 677361 263738 78801768
Metabolic acidosis 135.81 10.15 314 678568 82215 78983291
Hip arthroplasty 132.73 10.15 630 678252 35126 79030380
Hypoglycaemia 126.99 10.15 441 678441 101153 78964353
Respiratory depression 126.17 10.15 39 678843 27591 79037915
Poisoning 124.11 10.15 31 678851 25241 79040265
Tachycardia 124.08 10.15 944 677938 176824 78888682
Intentional product misuse 123.78 10.15 406 678476 94759 78970747
Blood pressure systolic increased 123.19 10.15 984 677898 66002 78999504
Angioedema 117.45 10.15 299 678583 75736 78989770
Treatment failure 116.58 10.15 2070 676812 168416 78897090
Drug dependence 114.21 10.15 107 678775 40662 79024844
Altered state of consciousness 109.26 10.15 127 678755 43695 79021811
Blood pressure increased 105.27 10.15 2448 676434 208912 78856594
Cholestasis 104.96 10.15 176 678706 51933 79013573
Shock 103.50 10.15 131 678751 43417 79022089
Rheumatic fever 102.55 10.15 498 678384 28027 79037479
Heart rate decreased 102.29 10.15 981 677901 69335 78996171
Hyperglycaemia 102.27 10.15 285 678597 70050 78995456
Hepatocellular injury 102.24 10.15 154 678728 47439 79018067
Blood pressure systolic abnormal 101.76 10.15 351 678531 16896 79048610
Disseminated intravascular coagulation 101.67 10.15 93 678789 35749 79029757
Somnolence 99.53 10.15 1433 677449 237548 78827958
Abortion spontaneous 98.89 10.15 505 678377 29002 79036504
Intentional self-injury 98.20 10.15 79 678803 32340 79033166
Pregnancy 95.26 10.15 467 678415 26384 79039122
Blood pressure diastolic abnormal 94.93 10.15 369 678513 18833 79046673
Hyperkalaemia 94.45 10.15 578 678304 113820 78951686
Intentional product use issue 94.27 10.15 1819 677063 150293 78915213
Red blood cell sedimentation rate increased 94.03 10.15 692 678190 45250 79020256
Leukopenia 92.94 10.15 595 678287 115918 78949588
Ill-defined disorder 92.86 10.15 913 677969 64962 79000544
Condition aggravated 91.97 10.15 5179 673703 495945 78569561
Ventricular fibrillation 91.56 10.15 82 678800 31844 79033662
Cardiogenic shock 89.68 10.15 136 678746 41778 79023728
Infection 89.31 10.15 2692 676190 239020 78826486
Loss of personal independence in daily activities 89.05 10.15 1296 677586 101284 78964222
Enthesopathy 88.43 10.15 258 678624 11350 79054156
Joint effusion 88.10 10.15 345 678537 17669 79047837
Acute hepatic failure 87.98 10.15 76 678806 30037 79035469
Anaphylactic shock 87.94 10.15 106 678776 35890 79029616
Ventricular tachycardia 87.87 10.15 138 678744 41797 79023709
Sedation complication 87.85 10.15 14 678868 15655 79049851
Swollen joint count increased 85.12 10.15 404 678478 22523 79042983
Blood creatine phosphokinase increased 84.54 10.15 284 678598 65806 78999700
Seizure 84.44 10.15 1116 677766 187718 78877788
Post transplant lymphoproliferative disorder 84.16 10.15 3 678879 11461 79054045
Oropharyngeal pain 83.93 10.15 1353 677529 108000 78957506
Grip strength decreased 83.86 10.15 389 678493 21480 79044026
Rash 82.77 10.15 5850 673032 572508 78492998
Agranulocytosis 82.71 10.15 161 678721 44869 79020637
Injection site erythema 81.90 10.15 1022 677860 77175 78988331
Ascites 80.32 10.15 350 678532 75212 78990294
Osteoporosis 78.24 10.15 754 678128 53358 79012148
Blood pressure diastolic decreased 77.95 10.15 482 678400 29734 79035772
Neurotoxicity 77.09 10.15 98 678784 32420 79033086
Inflammation 76.51 10.15 1172 677710 92581 78972925
Neuroleptic malignant syndrome 76.41 10.15 73 678809 27486 79038020
Musculoskeletal pain 75.80 10.15 1259 677623 101095 78964411
Encephalopathy 75.46 10.15 306 678576 67091 78998415
Mydriasis 75.18 10.15 28 678854 17615 79047891
Weight decreased 74.34 10.15 3717 675165 351481 78714025
Disability assessment scale score increased 73.89 10.15 117 678765 3341 79062165
Carpal tunnel syndrome 73.15 10.15 345 678537 19183 79046323
Cytokine release syndrome 73.04 10.15 121 678761 35877 79029629
Venoocclusive liver disease 71.99 10.15 8 678874 11763 79053743
Hypoxia 71.65 10.15 549 678333 102694 78962812
Drug ineffective for unapproved indication 70.56 10.15 213 678669 51025 79014481
Myocardial infarction 70.16 10.15 1123 677759 183006 78882500
Aspergillus infection 69.77 10.15 38 678844 19123 79046383
Cerebral haemorrhage 69.62 10.15 254 678628 57419 79008087
Injection site reaction 69.44 10.15 743 678139 54042 79011464
Hypothermia 69.43 10.15 55 678827 22691 79042815
Sepsis 69.38 10.15 1754 677128 267674 78797832
Localised infection 68.54 10.15 551 678331 37024 79028482
Proteinuria 68.06 10.15 107 678775 32395 79033111
Posterior reversible encephalopathy syndrome 67.88 10.15 74 678808 26207 79039299
Injection site pruritus 67.59 10.15 602 678280 41681 79023825
Toxic epidermal necrolysis 67.55 10.15 177 678705 44404 79021102
Torsade de pointes 66.48 10.15 41 678841 19271 79046235
Thrombotic microangiopathy 66.46 10.15 45 678837 20124 79045382
Drug level increased 65.92 10.15 150 678732 39501 79026005
Transplant rejection 65.90 10.15 42 678840 19395 79046111
Gamma-glutamyltransferase increased 65.89 10.15 241 678641 54439 79011067
Injection site pain 64.96 10.15 1505 677377 128333 78937173
Myelosuppression 64.94 10.15 155 678727 40141 79025365
Palmar-plantar erythrodysaesthesia syndrome 64.82 10.15 114 678768 33020 79032486
Drug withdrawal syndrome 64.75 10.15 123 678759 34595 79030911
Vomiting 64.22 10.15 4840 674042 660988 78404518
Pathogen resistance 64.14 10.15 21 678861 14321 79051185
Miosis 64.09 10.15 27 678855 15762 79049744
Ejection fraction 63.25 10.15 87 678795 2182 79063324
Blood cholesterol increased 63.17 10.15 1033 677849 82687 78982819
Acute respiratory distress syndrome 62.26 10.15 181 678701 43886 79021620
Foot deformity 62.08 10.15 384 678498 23690 79041816
Sensitisation 61.28 10.15 105 678777 3206 79062300
Polycystic ovaries 61.14 10.15 113 678769 3666 79061840
Hyperhidrosis 61.08 10.15 914 677968 150578 78914928
Respiratory distress 60.92 10.15 272 678610 58067 79007439
Ejection fraction decreased 60.62 10.15 127 678755 34450 79031056
Creatinine renal clearance decreased 60.49 10.15 44 678838 18958 79046548
Rheumatoid nodule 60.23 10.15 301 678581 17137 79048369
Rash maculo-papular 60.05 10.15 259 678623 55819 79009687
Substance abuse 59.93 10.15 9 678873 10517 79054989
Suicidal ideation 59.77 10.15 392 678490 75948 78989558
Juvenile idiopathic arthritis 59.69 10.15 128 678754 4635 79060871
Basal cell carcinoma 59.67 10.15 532 678350 36843 79028663
Delirium 59.67 10.15 448 678434 84179 78981327
Psychotic disorder 59.27 10.15 169 678713 41233 79024273
Stomatitis 59.25 10.15 1653 677229 145104 78920402
Anaphylactic reaction 59.20 10.15 443 678439 83300 78982206
Status epilepticus 58.81 10.15 76 678806 24965 79040541
Bronchopulmonary aspergillosis 58.44 10.15 62 678820 22232 79043274
Neoplasm progression 58.26 10.15 234 678648 51448 79014058
Tumour lysis syndrome 57.95 10.15 71 678811 23868 79041638
Hepatotoxicity 57.58 10.15 233 678649 51119 79014387
Appendicolith 57.20 10.15 4 678878 8547 79056959
Joint stiffness 57.10 10.15 565 678317 40265 79025241
Haemophagocytic lymphohistiocytosis 56.94 10.15 61 678821 21776 79043730
Cardiac failure congestive 56.77 10.15 861 678021 141541 78923965
Gastrointestinal disorder 56.72 10.15 1402 677480 120803 78944703
Mucormycosis 56.54 10.15 4 678878 8465 79057041
Joint range of motion decreased 56.40 10.15 480 678402 32802 79032704
Hypokalaemia 56.37 10.15 874 678008 143166 78922340
Cerebral infarction 55.90 10.15 200 678682 45476 79020030
Body temperature decreased 55.21 10.15 465 678417 31680 79033826
Acute graft versus host disease 54.98 10.15 10 678872 10157 79055349
Influenza 54.35 10.15 1467 677415 128139 78937367
Aggression 54.17 10.15 236 678646 50722 79014784
C-reactive protein increased 53.97 10.15 1460 677422 127567 78937939
Injection site swelling 53.71 10.15 626 678256 46506 79019000
Acute generalised exanthematous pustulosis 53.58 10.15 41 678841 17213 79048293
Joint destruction 53.36 10.15 140 678742 5785 79059721
Caesarean section 53.35 10.15 230 678652 12305 79053201
Orthostatic hypotension 53.30 10.15 271 678611 55893 79009613
Akathisia 53.29 10.15 23 678859 13236 79052270
Extrapyramidal disorder 53.09 10.15 69 678813 22610 79042896
Coagulopathy 53.00 10.15 145 678737 35861 79029645
Septic shock 52.97 10.15 731 678151 122070 78943436
Tenosynovitis 52.68 10.15 267 678615 15287 79050219
Immune reconstitution inflammatory syndrome 52.55 10.15 26 678856 13815 79051691
Fall 52.42 10.15 4826 674056 482803 78582703
Pyrexia 52.19 10.15 5022 673860 673687 78391819
Brain oedema 52.11 10.15 84 678798 25179 79040327
Bone erosion 52.03 10.15 294 678588 17553 79047953
Osteonecrosis of jaw 51.76 10.15 191 678691 43035 79022471
Exposure to toxic agent 51.75 10.15 8 678874 9150 79056356
Anaemia 51.64 10.15 3182 675700 441833 78623673
Live birth 51.53 10.15 304 678578 18440 79047066
Injection site bruising 51.46 10.15 555 678327 40447 79025059
Pancreatitis acute 51.36 10.15 232 678650 49372 79016134
Polyarthritis 51.25 10.15 223 678659 11979 79053527
Inappropriate antidiuretic hormone secretion 51.05 10.15 91 678791 26222 79039284
Asphyxia 50.95 10.15 18 678864 11702 79053804
Syncope 50.92 10.15 1151 677731 178298 78887208
Haematotoxicity 50.63 10.15 35 678847 15484 79050022
Disturbance in attention 50.59 10.15 241 678641 50560 79014946
Hypoaesthesia 49.66 10.15 1932 676950 177420 78888086
Dystonia 49.17 10.15 66 678816 21333 79044173
Toxic skin eruption 48.99 10.15 71 678811 22222 79043284
Coronary artery disease 48.38 10.15 342 678540 65132 79000374
Joint laxity 48.29 10.15 78 678804 2266 79063240
Tendonitis 48.22 10.15 358 678524 23472 79042034
Myoclonus 48.15 10.15 102 678780 27558 79037948
Accidental overdose 47.98 10.15 174 678708 39407 79026099
Poor venous access 47.75 10.15 291 678591 17858 79047648
Interstitial lung disease 46.89 10.15 675 678207 111925 78953581
BK virus infection 46.88 10.15 9 678873 8795 79056711
Ear infection 46.48 10.15 473 678409 33959 79031547
Stevens-Johnson syndrome 46.28 10.15 174 678708 38992 79026514
Graft versus host disease 46.28 10.15 36 678846 14990 79050516
Sinus tachycardia 46.24 10.15 160 678722 36748 79028758
Blood pressure diastolic increased 46.05 10.15 245 678637 14297 79051209
Pulmonary fibrosis 45.95 10.15 576 678306 43536 79021970
Adverse event 45.81 10.15 744 678138 59470 79006036
Unresponsive to stimuli 44.93 10.15 284 678598 55504 79010002
No adverse event 44.75 10.15 164 678718 37028 79028478
Skin cancer 44.66 10.15 249 678633 14791 79050715
Rhinorrhoea 44.50 10.15 902 677980 75172 78990334
Laryngitis 44.01 10.15 260 678622 15779 79049727
Melaena 43.56 10.15 321 678561 60569 79004937
Femur fracture 43.44 10.15 512 678370 38140 79027366
Constipation 43.35 10.15 1968 676914 281082 78784424
Hyperthermia 43.13 10.15 54 678828 17983 79047523
Haemoptysis 42.61 10.15 290 678592 55709 79009797
Cognitive disorder 42.54 10.15 385 678497 69541 78995965
Gestational diabetes 42.43 10.15 134 678748 6159 79059347
Synovial cyst 42.32 10.15 184 678698 9881 79055625
Drug hypersensitivity 42.08 10.15 2097 676785 296819 78768687
Erythema multiforme 42.04 10.15 53 678829 17598 79047908
Gastroenteritis viral 42.01 10.15 358 678524 24473 79041033
Ischaemic stroke 41.93 10.15 143 678739 32988 79032518
Cytomegalovirus viraemia 41.72 10.15 29 678853 12792 79052714
Blood creatinine increased 41.35 10.15 1004 677878 154053 78911453
Pulmonary alveolar haemorrhage 41.31 10.15 23 678859 11434 79054072
Mania 41.27 10.15 57 678825 18203 79047303
Off label use 40.95 10.15 6946 671936 900269 78165237
Tachypnoea 40.85 10.15 138 678744 31925 79033581
Mobility decreased 40.68 10.15 1344 677538 120831 78944675
Acute myeloid leukaemia 40.68 10.15 131 678751 30754 79034752
Ankylosing spondylitis 40.28 10.15 208 678674 11997 79053509
Disorientation 40.24 10.15 341 678541 62435 79003071
Diabetic ketoacidosis 40.06 10.15 152 678730 33970 79031536
Fear 40.04 10.15 79 678803 21907 79043599
Neutrophil count decreased 39.92 10.15 561 678321 93398 78972108
Neck mass 39.60 10.15 104 678778 4300 79061206
Anuria 39.33 10.15 74 678808 20889 79044617
Blood bilirubin increased 39.28 10.15 367 678515 65865 78999641
Disability 39.19 10.15 265 678617 16855 79048651
Irritability 38.77 10.15 199 678683 40945 79024561
Klebsiella infection 38.71 10.15 46 678836 15674 79049832
Second primary malignancy 38.64 10.15 39 678843 14311 79051195
Wrong technique in product usage process 38.57 10.15 422 678460 73453 78992053
Eosinophilia 38.52 10.15 227 678655 45118 79020388
Abnormal behaviour 38.51 10.15 169 678713 36252 79029254
Acute graft versus host disease in skin 38.38 10.15 9 678873 7649 79057857
Hyperbilirubinaemia 38.18 10.15 96 678786 24422 79041084
Metastases to liver 38.06 10.15 119 678763 28195 79037311
Tongue disorder 37.99 10.15 226 678656 13749 79051757
Joint injury 37.87 10.15 421 678461 30914 79034592
Arrhythmia 37.86 10.15 336 678546 60936 79004570
Jaundice 37.80 10.15 282 678600 53067 79012439
Spinal stenosis 37.70 10.15 247 678635 15544 79049962
Psychomotor hyperactivity 37.68 10.15 53 678829 16796 79048710
Gait disturbance 37.44 10.15 2142 676740 205364 78860142
Withdrawal syndrome 37.43 10.15 111 678771 26743 79038763
Nodule 37.07 10.15 328 678554 22666 79042840
Red blood cell sedimentation rate 37.06 10.15 118 678764 5447 79060059
Adenovirus infection 36.68 10.15 13 678869 8434 79057072
Blood glucose increased 36.54 10.15 724 678158 114251 78951255
Clostridium difficile colitis 36.49 10.15 146 678736 32137 79033369
Injection site rash 36.48 10.15 270 678612 17684 79047822
Blood alkaline phosphatase increased 36.38 10.15 356 678526 63308 79002198
Colorectal cancer 36.38 10.15 14 678868 8633 79056873
Blood test abnormal 36.37 10.15 267 678615 17443 79048063
Neck deformity 36.32 10.15 60 678822 1777 79063729
Intestinal stenosis 36.19 10.15 91 678791 3663 79061843
Speech disorder 36.14 10.15 293 678589 54152 79011354
Acidosis 35.99 10.15 71 678811 19691 79045815
Electrocardiogram QRS complex prolonged 35.92 10.15 24 678858 10809 79054697
Myocardial ischaemia 35.91 10.15 105 678777 25414 79040092
Febrile bone marrow aplasia 35.50 10.15 35 678847 12985 79052521
Stress cardiomyopathy 35.36 10.15 26 678856 11140 79054366
Hepatitis B reactivation 35.29 10.15 5 678877 6103 79059403
International normalised ratio increased 35.23 10.15 508 678374 84213 78981293
Unintentional medical device removal 35.01 10.15 11 678871 7701 79057805
Polyneuropathy 35.00 10.15 98 678784 24053 79041453
Alanine aminotransferase abnormal 34.94 10.15 159 678723 8708 79056798
Therapy partial responder 34.81 10.15 59 678823 17338 79048168
Fracture 34.64 10.15 310 678572 21491 79044015
Neck pain 34.62 10.15 864 678018 74553 78990953
Leukocytosis 34.59 10.15 222 678660 43233 79022273
Burning sensation 34.56 10.15 696 678186 57936 79007570
Nocardiosis 34.38 10.15 4 678878 5675 79059831
Acute myocardial infarction 34.14 10.15 456 678426 76580 78988926
Pseudomonas infection 34 10.15 80 678802 20823 79044683
Nasal congestion 33.96 10.15 873 678009 75679 78989827
Tenderness 33.96 10.15 329 678553 23313 79042193
Loss of consciousness 33.95 10.15 1130 677752 166813 78898693
Hyperammonaemia 33.63 10.15 27 678855 11066 79054440
Diabetes insipidus 33.49 10.15 3 678879 5234 79060272
Bradyphrenia 33.40 10.15 25 678857 10615 79054891
Exostosis 33.40 10.15 252 678630 16606 79048900
Temperature regulation disorder 33.33 10.15 5 678877 5848 79059658
Cardiotoxicity 33.26 10.15 33 678849 12206 79053300
Face oedema 33.24 10.15 125 678757 28011 79037495
Pneumatosis intestinalis 33.10 10.15 7 678875 6390 79059116
Latent tuberculosis 33.08 10.15 82 678800 3271 79062235
Bronchospasm 33.05 10.15 105 678777 24754 79040752
Wheelchair user 32.93 10.15 121 678761 6011 79059495
Atrial fibrillation 32.52 10.15 1365 677517 196521 78868985
Pemphigoid 32.46 10.15 50 678832 15265 79050241
Restlessness 32.35 10.15 247 678635 46245 79019261
Acute chest syndrome 32.23 10.15 52 678830 1509 79063997
Cystitis haemorrhagic 32.23 10.15 19 678863 9153 79056353
Intestinal resection 32.04 10.15 87 678795 3670 79061836
Red blood cell count decreased 32.02 10.15 677 678205 56836 79008670
Chronic graft versus host disease 32.00 10.15 9 678873 6772 79058734
Myalgia 31.90 10.15 1274 677608 184367 78881139
Urinary tract infection 31.76 10.15 2732 676150 271780 78793726
Blood calcium decreased 31.65 10.15 151 678731 31668 79033838
Breast cancer stage I 31.42 10.15 9 678873 6691 79058815
Multiple-drug resistance 31.30 10.15 18 678864 8790 79056716
Bone marrow failure 31.25 10.15 281 678601 50826 79014680
Pulmonary haemorrhage 31.24 10.15 48 678834 14669 79050837
Maternal exposure before pregnancy 31.23 10.15 95 678787 4278 79061228
Infective pulmonary exacerbation of cystic fibrosis 31.22 10.15 38 678844 12813 79052693
Metastases to bone 31.21 10.15 105 678777 24322 79041184
Acute coronary syndrome 31.18 10.15 85 678797 21048 79044458
Hepatic encephalopathy 30.79 10.15 104 678778 24062 79041444
Forced expiratory volume decreased 30.71 10.15 14 678868 7800 79057706
Drug use disorder 30.29 10.15 18 678864 8633 79056873
Multiple fractures 30.21 10.15 142 678740 7884 79057622
Headache 30.21 10.15 6153 672729 647619 78417887
Circulatory collapse 30.21 10.15 192 678690 37476 79028030
Bronchitis 30.20 10.15 1381 677501 129263 78936243
Foot fracture 30.17 10.15 303 678579 21678 79043828
Shock haemorrhagic 30.12 10.15 80 678802 19980 79045526
Paradoxical drug reaction 29.63 10.15 12 678870 7173 79058333
Hepatitis cholestatic 29.58 10.15 45 678837 13807 79051699
Haemodynamic instability 29.51 10.15 65 678817 17317 79048189
Arthritis infective 29.44 10.15 144 678738 8127 79057379
Pulmonary oedema 29.18 10.15 552 678330 87702 78977804
Aspartate aminotransferase increased 29.17 10.15 928 677954 137713 78927793
Peripheral sensory neuropathy 29.14 10.15 41 678841 12992 79052514
Hypomagnesaemia 29.09 10.15 257 678625 46654 79018852
Mental status changes 29.08 10.15 398 678484 66561 78998945
Generalised tonic-clonic seizure 28.83 10.15 237 678645 43673 79021833
Epstein-Barr virus infection 28.74 10.15 49 678833 14367 79051139
Haemorrhage intracranial 28.64 10.15 120 678762 26073 79039433
Herpes zoster 28.47 10.15 1014 677868 92069 78973437
Surgery 28.43 10.15 414 678468 32352 79033154
Transplant dysfunction 28.28 10.15 13 678869 7208 79058298
Skin papilloma 28.19 10.15 112 678770 5774 79059732
Tubulointerstitial nephritis 28.10 10.15 200 678682 38035 79027471
Cyst 28.05 10.15 208 678674 13632 79051874
Cytomegalovirus infection reactivation 27.98 10.15 20 678862 8696 79056810
Nephrectomy 27.85 10.15 58 678824 2057 79063449
Pleural effusion 27.82 10.15 984 677898 144278 78921228
Faecal calprotectin increased 27.81 10.15 107 678775 5434 79060072
Jaundice cholestatic 27.81 10.15 33 678849 11251 79054255
Skin ulcer 27.79 10.15 630 678252 53520 79011986
Oesophageal carcinoma 27.76 10.15 32 678850 11052 79054454
Purpura 27.73 10.15 80 678802 19447 79046059
Pre-eclampsia 27.55 10.15 126 678756 6915 79058591
Pancreatitis 27.53 10.15 414 678468 68161 78997345
Sexual dysfunction 27.40 10.15 16 678866 7747 79057759
Haemoglobin decreased 27.34 10.15 2221 676661 219898 78845608
Respiratory acidosis 27.34 10.15 33 678849 11167 79054339
Hyperlactacidaemia 27.21 10.15 7 678875 5588 79059918
Blood parathyroid hormone decreased 27.13 10.15 168 678714 10368 79055138
Tooth disorder 27.09 10.15 342 678540 25891 79039615
Bladder cancer 27.00 10.15 81 678801 19445 79046061
Catatonia 26.94 10.15 21 678861 8735 79056771
Frequent bowel movements 26.73 10.15 376 678506 29163 79036343
Hallucination 26.62 10.15 542 678340 85203 78980303
Hepatitis acute 26.48 10.15 58 678824 15484 79050022
Cytopenia 26.47 10.15 87 678795 20296 79045210
Cytomegalovirus chorioretinitis 26.45 10.15 7 678875 5483 79060023
Pulmonary arterial hypertension 26.28 10.15 138 678744 28228 79037278
Vitamin D decreased 26.26 10.15 157 678725 9568 79055938
Mouth ulceration 26.14 10.15 466 678416 37928 79027578
Product dose omission issue 26.10 10.15 2447 676435 245090 78820416
Type 2 diabetes mellitus 26.09 10.15 654 678228 56468 79009038
Potentiating drug interaction 26.08 10.15 22 678860 8797 79056709
Cyanosis 25.93 10.15 118 678764 25064 79040442
Nephropathy toxic 25.93 10.15 88 678794 20331 79045175
Upper respiratory tract infection 25.91 10.15 985 677897 90183 78975323
Therapeutic reaction time decreased 25.89 10.15 77 678805 3424 79062082
Venoocclusive disease 25.83 10.15 4 678878 4569 79060937
Parkinsonism 25.77 10.15 65 678817 16519 79048987
Gastrointestinal haemorrhage 25.75 10.15 1012 677870 146707 78918799
Transaminases increased 25.66 10.15 299 678583 51444 79014062
Hepatitis fulminant 25.58 10.15 15 678867 7247 79058259
Muscle twitching 25.53 10.15 116 678766 24648 79040858
Hyperuricaemia 25.51 10.15 38 678844 11761 79053745
Ulcer 25.34 10.15 377 678505 29595 79035911
Full blood count decreased 25.34 10.15 344 678538 26475 79039031
Graft versus host disease in skin 25.27 10.15 10 678872 6063 79059443
Virologic failure 25.25 10.15 3 678879 4188 79061318
Renal injury 25.04 10.15 68 678814 16859 79048647
Smear cervix abnormal 25.00 10.15 62 678820 2474 79063032
Pulmonary embolism 24.95 10.15 1200 677682 170454 78895052
Alanine aminotransferase increased 24.93 10.15 1130 677752 161440 78904066
Cardiac failure chronic 24.93 10.15 35 678847 11100 79054406
Dermatitis acneiform 24.87 10.15 29 678853 9964 79055542
Metastases to central nervous system 24.81 10.15 65 678817 16310 79049196
Post procedural infection 24.75 10.15 174 678708 11210 79054296
Bursitis 24.75 10.15 436 678446 35408 79030098
Metastases to lung 24.65 10.15 76 678806 18087 79047419
Mucosal inflammation 24.59 10.15 474 678408 75106 78990400
Device use error 24.55 10.15 15 678867 7086 79058420
Sinus bradycardia 24.42 10.15 121 678761 25126 79040380
Sciatica 24.34 10.15 408 678474 32814 79032692
Rotator cuff repair 24.30 10.15 51 678831 1819 79063687
Heparin-induced thrombocytopenia 24.20 10.15 28 678854 9654 79055852
Hypocalcaemia 24.18 10.15 290 678592 49634 79015872
Granuloma skin 24.07 10.15 147 678735 9027 79056479
Inappropriate schedule of product administration 24.01 10.15 1379 677503 132249 78933257
Blood lactic acid increased 23.90 10.15 45 678837 12699 79052807
Myopathy 23.88 10.15 92 678790 20471 79045035
Limb deformity 23.80 10.15 76 678806 3514 79061992
Malignant mediastinal neoplasm 23.76 10.15 43 678839 1372 79064134
Bone disorder 23.65 10.15 258 678624 18855 79046651
Hypoalbuminaemia 23.64 10.15 97 678785 21200 79044306
Toxic encephalopathy 23.63 10.15 38 678844 11402 79054104
Schizophrenia 23.62 10.15 61 678821 15379 79050127
Scleritis 23.43 10.15 86 678796 4270 79061236
Angina pectoris 23.37 10.15 305 678577 51427 79014079
Adjustment disorder 23.24 10.15 81 678801 3919 79061587
Enterocolitis 23.24 10.15 56 678826 14456 79051050
Peripheral venous disease 23.15 10.15 222 678660 15687 79049819
Malignant melanoma 23.11 10.15 209 678673 14532 79050974
Pruritus genital 23.03 10.15 5 678877 4481 79061025
Premature labour 23.01 10.15 136 678746 8254 79057252
Vitamin B12 deficiency 22.93 10.15 122 678760 7119 79058387
Haematemesis 22.93 10.15 310 678572 51954 79013552
Hyperthyroidism 22.91 10.15 104 678778 22105 79043401
Tardive dyskinesia 22.90 10.15 34 678848 10537 79054969
Left ventricular dysfunction 22.88 10.15 86 678796 19275 79046231
Sudden death 22.88 10.15 106 678776 22405 79043101
Dyspnoea 22.87 10.15 6729 672153 850296 78215210
Pharyngitis streptococcal 22.85 10.15 163 678719 10551 79054955
Subdural haematoma 22.82 10.15 165 678717 31269 79034237
Disturbance in social behaviour 22.72 10.15 7 678875 4963 79060543
Hepatocellular carcinoma 22.64 10.15 26 678856 8995 79056511
Tuberculosis 22.57 10.15 213 678669 14985 79050521
Joint dislocation 22.53 10.15 232 678650 16707 79048799
Neurologic neglect syndrome 22.52 10.15 65 678817 2842 79062664
Accidental exposure to product 22.46 10.15 165 678717 31157 79034349
Hyperprolactinaemia 22.46 10.15 6 678876 4670 79060836
Hypertransaminasaemia 22.45 10.15 42 678840 11882 79053624
Premature rupture of membranes 22.45 10.15 81 678801 3988 79061518
Facet joint syndrome 22.42 10.15 169 678713 11133 79054373
Chronic kidney disease 22.42 10.15 412 678470 65742 78999764
Respiratory disorder 22.32 10.15 259 678623 44597 79020909
Immune effector cell-associated neurotoxicity syndrome 22.18 10.15 11 678871 5837 79059669
Lupus-like syndrome 21.99 10.15 197 678685 13660 79051846
Obstructive airways disorder 21.95 10.15 167 678715 31292 79034214
Hydrops foetalis 21.94 10.15 30 678852 748 79064758
Paranoia 21.89 10.15 88 678794 19344 79046162
Ileus 21.85 10.15 132 678750 26079 79039427
Fear of injection 21.70 10.15 123 678759 7351 79058155
Nephrolithiasis 21.70 10.15 601 678281 52690 79012816
Pulseless electrical activity 21.62 10.15 56 678826 14104 79051402
Accidental death 21.59 10.15 5 678877 4286 79061220
Cross sensitivity reaction 21.54 10.15 3 678879 3709 79061797
Hepatic cytolysis 21.46 10.15 139 678743 27012 79038494
Maternal exposure timing unspecified 21.45 10.15 102 678780 5690 79059816
Rebound effect 21.40 10.15 18 678864 7208 79058298
Sleep disorder due to a general medical condition 21.16 10.15 200 678682 14077 79051429
Appendicitis 21.08 10.15 98 678784 20696 79044810
Increased tendency to bruise 21.06 10.15 157 678725 10307 79055199
Kidney infection 20.94 10.15 281 678601 21570 79043936
Hydrocephalus 20.91 10.15 27 678855 8873 79056633
Lip dry 20.90 10.15 212 678670 15206 79050300
Hyperpyrexia 20.88 10.15 13 678869 6079 79059427
Atrial tachycardia 20.84 10.15 18 678864 7115 79058391
Strongyloidiasis 20.72 10.15 4 678878 3894 79061612
Colitis ulcerative 20.67 10.15 413 678469 34329 79031177
Retinitis 20.63 10.15 99 678783 5544 79059962
Bradypnoea 20.62 10.15 13 678869 6039 79059467
Immunosuppressant drug level increased 20.58 10.15 28 678854 8999 79056507
Carotid artery thrombosis 20.57 10.15 65 678817 2988 79062518
Cardiac failure acute 20.52 10.15 87 678795 18842 79046664
Rheumatoid lung 20.51 10.15 81 678801 4164 79061342
Subarachnoid haemorrhage 20.50 10.15 123 678759 24342 79041164
Acute pulmonary oedema 20.43 10.15 58 678824 14172 79051334
Intervertebral disc degeneration 20.43 10.15 215 678667 15570 79049936
Intercepted product preparation error 20.37 10.15 3 678879 3557 79061949
Wound infection 20.37 10.15 302 678580 23689 79041817
Haemorrhage 20.36 10.15 605 678277 90513 78974993
Alcohol interaction 20.33 10.15 8 678874 4866 79060640
Tenosynovitis stenosans 20.26 10.15 65 678817 3013 79062493
Product administered to patient of inappropriate age 20.24 10.15 11 678871 5542 79059964
Aplasia 20.22 10.15 22 678860 7798 79057708
Joint noise 20.16 10.15 77 678805 3897 79061609
Compartment syndrome 20.13 10.15 9 678873 5073 79060433
Ultrasound antenatal screen 19.97 10.15 27 678855 666 79064840
Hypernatraemia 19.95 10.15 60 678822 14391 79051115
Drug-induced liver injury 19.91 10.15 420 678462 65697 78999809
Rash pruritic 19.90 10.15 772 678110 70857 78994649
Therapeutic response decreased 19.89 10.15 726 678156 66127 78999379
Renal tubular necrosis 19.89 10.15 128 678754 24911 79040595
Bacteraemia 19.84 10.15 181 678701 32643 79032863
Cleft lip and palate 19.81 10.15 27 678855 671 79064835
Cerebral haematoma 19.81 10.15 23 678859 7919 79057587
Emotional distress 19.81 10.15 231 678651 39738 79025768
Pulmonary congestion 19.80 10.15 142 678740 26958 79038548
Progressive multifocal leukoencephalopathy 19.77 10.15 99 678783 20501 79045005
Acute graft versus host disease in intestine 19.76 10.15 5 678877 4036 79061470
Hypomania 19.75 10.15 21 678861 7523 79057983
Hypertriglyceridaemia 19.74 10.15 50 678832 12690 79052816
Incorrect route of product administration 19.67 10.15 196 678686 34733 79030773
Nephrotic syndrome 19.62 10.15 41 678841 11133 79054373
Disease recurrence 19.58 10.15 261 678621 43848 79021658
Lymphopenia 19.57 10.15 166 678716 30391 79035115
Blood lactate dehydrogenase increased 19.56 10.15 226 678656 38944 79026562
Hallucination, auditory 19.54 10.15 100 678782 20593 79044913
Vitamin B12 decreased 19.53 10.15 70 678812 3435 79062071
Anti-cyclic citrullinated peptide antibody 19.50 10.15 100 678782 5752 79059754
Synovial fluid analysis 19.50 10.15 54 678828 2305 79063201
Postoperative wound infection 19.42 10.15 182 678700 12779 79052727
Glycosylated haemoglobin increased 19.39 10.15 91 678791 19169 79046337
Knee operation 19.38 10.15 100 678782 5766 79059740
Kidney transplant rejection 19.37 10.15 36 678846 10210 79055296
Dysstasia 19.33 10.15 338 678544 27408 79038098
Ejection fraction abnormal 19.33 10.15 55 678827 2385 79063121
Acute lymphocytic leukaemia recurrent 19.30 10.15 8 678874 4716 79060790
Haematocrit decreased 19.27 10.15 670 678212 60642 79004864
Panniculitis 19.19 10.15 175 678707 12196 79053310
Device expulsion 19.14 10.15 135 678747 25726 79039780
Hallucination, visual 19.13 10.15 182 678700 32547 79032959
Dyskinesia 19.13 10.15 267 678615 44506 79021000
Foot operation 19.13 10.15 98 678784 5635 79059871
Hypercapnia 19.10 10.15 29 678853 8906 79056600
Blood urea increased 19.09 10.15 296 678586 48494 79017012
Endophthalmitis 19.05 10.15 16 678866 6412 79059094
Human herpesvirus 6 infection 19.05 10.15 11 678871 5359 79060147
Drug abuser 19.04 10.15 14 678868 5999 79059507
Persecutory delusion 18.97 10.15 9 678873 4900 79060606
Oliguria 18.92 10.15 73 678809 16236 79049270
Sleep apnoea syndrome 18.90 10.15 425 678457 36053 79029453
Loose body in joint 18.82 10.15 37 678845 1258 79064248
Epilepsy 18.79 10.15 240 678642 40620 79024886
Intracranial pressure increased 18.79 10.15 26 678856 8296 79057210
Skin toxicity 18.74 10.15 26 678856 8288 79057218
Labelled drug-drug interaction medication error 18.72 10.15 148 678734 27502 79038004
Complications of transplanted kidney 18.68 10.15 16 678866 6350 79059156
Heart rate irregular 18.62 10.15 386 678496 32293 79033213
Osteonecrosis 18.56 10.15 172 678710 30923 79034583
Pneumothorax 18.53 10.15 153 678729 28170 79037336
Blood iron decreased 18.48 10.15 207 678675 15227 79050279
Pneumocystis jirovecii pneumonia 18.48 10.15 182 678700 32326 79033180
Congestive cardiomyopathy 18.44 10.15 46 678836 11734 79053772
Dry eye 18.43 10.15 428 678454 36503 79029003
Cholangitis 18.39 10.15 52 678830 12724 79052782
Pneumonia aspiration 18.28 10.15 432 678450 66535 78998971
Psychomotor skills impaired 18.19 10.15 11 678871 5226 79060280
Fracture delayed union 18.14 10.15 49 678833 2061 79063445
Anal fissure 18.09 10.15 120 678762 7583 79057923
Synovial disorder 18.01 10.15 47 678835 1936 79063570
Trisomy 18 17.96 10.15 24 678858 585 79064921
Injection site warmth 17.92 10.15 199 678683 14608 79050898
Hernia 17.87 10.15 223 678659 16836 79048670
Product administration error 17.81 10.15 179 678703 31667 79033839
Muscle rigidity 17.71 10.15 98 678784 19784 79045722
Eye infection 17.67 10.15 167 678715 11753 79053753
Toothache 17.59 10.15 253 678629 19717 79045789
Adjustment disorder with depressed mood 17.54 10.15 135 678747 8951 79056555
Sleep terror 17.50 10.15 8 678874 4450 79061056
Product prescribing error 17.49 10.15 272 678610 44541 79020965
Palmoplantar keratoderma 17.41 10.15 5 678877 3711 79061795
Antinuclear antibody positive 17.39 10.15 121 678761 7769 79057737
Immunodeficiency 17.32 10.15 271 678611 21497 79044009
Type 1 diabetes mellitus 17.30 10.15 20 678862 6899 79058607
Spinal osteoarthritis 17.19 10.15 220 678662 16707 79048799
Urticaria 17.17 10.15 1350 677532 183851 78881655
Bacterial sepsis 17.15 10.15 27 678855 8171 79057335
Deep vein thrombosis postoperative 17.14 10.15 153 678729 10599 79054907
Ingrown hair 17.13 10.15 26 678856 715 79064791
Hypoxic-ischaemic encephalopathy 17.09 10.15 25 678857 7795 79057711
COVID-19 pneumonia 17.04 10.15 160 678722 28689 79036817
Hypertonia 16.93 10.15 22 678860 7210 79058296
Polyuria 16.91 10.15 68 678814 14946 79050560
Cataract 16.90 10.15 668 678214 61452 79004054
Diabetes mellitus 16.89 10.15 523 678359 77867 78987639
Coronary artery bypass 16.87 10.15 16 678866 6046 79059460
Hepatitis C 16.83 10.15 49 678833 11876 79053630
Small intestinal obstruction 16.83 10.15 326 678556 26946 79038560
Anal fistula 16.81 10.15 109 678773 6835 79058671
Coronary arterial stent insertion 16.77 10.15 16 678866 6028 79059478
Ventricular arrhythmia 16.76 10.15 31 678851 8809 79056697
Lower respiratory tract congestion 16.75 10.15 73 678809 3924 79061582
Bronchial secretion retention 16.69 10.15 7 678875 4097 79061409
Tremor 16.68 10.15 1234 677648 168849 78896657
End stage renal disease 16.68 10.15 51 678831 12169 79053337
Fistula 16.63 10.15 176 678706 12764 79052742
Abortion incomplete 16.60 10.15 3 678879 3061 79062445
Intervertebral disc protrusion 16.55 10.15 288 678594 23333 79042173
Oral herpes 16.54 10.15 327 678555 27127 79038379
Reversible cerebral vasoconstriction syndrome 16.54 10.15 3 678879 3054 79062452
Purging 16.53 10.15 8 678874 38 79065468
Gastric cancer 16.52 10.15 39 678843 10140 79055366
Blood phosphorus increased 16.51 10.15 40 678842 10307 79055199
Brain injury 16.49 10.15 47 678835 11470 79054036
Breast feeding 16.49 10.15 25 678857 687 79064819
Gastric haemorrhage 16.42 10.15 69 678813 14981 79050525
Dermatitis exfoliative 16.40 10.15 43 678839 10786 79054720
Tooth infection 16.36 10.15 238 678644 18594 79046912
Hepatic necrosis 16.31 10.15 33 678849 9067 79056439
Ketoacidosis 16.31 10.15 26 678856 7828 79057678
Injection site haemorrhage 16.14 10.15 330 678552 27540 79037966
Device difficult to use 16.12 10.15 59 678823 13326 79052180
Bone density abnormal 16.11 10.15 60 678822 3000 79062506
Ileal stenosis 16.11 10.15 51 678831 2347 79063159
Drug tolerance decreased 15.97 10.15 175 678707 12803 79052703
Affective disorder 15.93 10.15 29 678853 8290 79057216
Device related infection 15.93 10.15 201 678681 34093 79031413
Osteopenia 15.92 10.15 232 678650 18132 79047374
Benign neoplasm of adrenal gland 15.89 10.15 8 678874 42 79065464
Haematuria 15.89 10.15 455 678427 68381 78997125
Lower limb fracture 15.89 10.15 282 678600 22933 79042573
Polyhydramnios 15.86 10.15 41 678841 1679 79063827
Metabolic disorder 15.81 10.15 34 678848 9136 79056370
Hepatic cancer 15.80 10.15 42 678840 10487 79055019
Pneumonia bacterial 15.77 10.15 98 678784 19233 79046273
Palindromic rheumatism 15.74 10.15 19 678863 417 79065089
Drug screen positive 15.74 10.15 17 678865 6046 79059460
Dislocation of vertebra 15.73 10.15 118 678764 7762 79057744
Blood folate increased 15.62 10.15 21 678861 515 79064991
Type I hypersensitivity 15.61 10.15 9 678873 4389 79061117
Haematoma 15.59 10.15 332 678550 51863 79013643
Cardiomyopathy 15.57 10.15 163 678719 28611 79036895
Finger deformity 15.53 10.15 113 678769 7361 79058145
Ventricular hypokinesia 15.51 10.15 35 678847 9244 79056262
Acute respiratory failure 15.46 10.15 387 678495 59154 79006352
Nasal polyps 15.45 10.15 24 678858 7303 79058203
Chronic disease 15.41 10.15 12 678870 149 79065357
Gingival pain 15.36 10.15 130 678752 8868 79056638
Premature delivery 15.33 10.15 283 678599 23184 79042322
Gastrooesophageal reflux disease 15.27 10.15 1057 677825 103189 78962317
Pulmonary hypertension 15.20 10.15 303 678579 47777 79017729
Pseudomembranous colitis 15.17 10.15 14 678868 5360 79060146
Dry throat 15.16 10.15 115 678767 7591 79057915
Hepatitis B 15.12 10.15 30 678852 8302 79057204
Wrong product administered 15.05 10.15 34 678848 8978 79056528
Human antichimeric antibody positive 15.01 10.15 39 678843 1602 79063904
Angina unstable 14.98 10.15 81 678801 16446 79049060
Lacrimal disorder 14.92 10.15 20 678862 489 79065017
Obesity 14.83 10.15 398 678484 34727 79030779
Vascular purpura 14.83 10.15 4 678878 3094 79062412
Atrioventricular block complete 14.73 10.15 82 678800 16528 79048978
Hand fracture 14.63 10.15 97 678785 6128 79059378
Endodontic procedure 14.62 10.15 54 678828 2689 79062817
Pulmonary pain 14.60 10.15 76 678806 4397 79061109
Cystitis 14.57 10.15 568 678314 52164 79013342
Throat lesion 14.57 10.15 18 678864 405 79065101
Metastases to lymph nodes 14.47 10.15 43 678839 10354 79055152
Injection site urticaria 14.45 10.15 170 678712 12656 79052850
Myocarditis 14.40 10.15 117 678765 21616 79043890
Epstein-Barr virus associated lymphoproliferative disorder 14.40 10.15 6 678876 3526 79061980
Platelet count decreased 14.38 10.15 1444 677438 193220 78872286
Hypogammaglobulinaemia 14.37 10.15 59 678823 12892 79052614
Limb injury 14.36 10.15 341 678541 29187 79036319
Toxic anterior segment syndrome 14.35 10.15 3 678879 2761 79062745
Visual acuity reduced 14.34 10.15 171 678711 29298 79036208
Arthropod bite 14.26 10.15 122 678760 8349 79057157
Candida infection 14.23 10.15 234 678648 37980 79027526
Psychiatric decompensation 14.23 10.15 8 678874 3955 79061551
Anti-neutrophil cytoplasmic antibody positive vasculitis 14.16 10.15 7 678875 3722 79061784
Metabolic surgery 14.09 10.15 31 678851 1143 79064363
Antibody test positive 14.08 10.15 54 678828 2738 79062768
Iodine allergy 14.04 10.15 21 678861 570 79064936
Tonsillar inflammation 14.03 10.15 11 678871 138 79065368
Abdominal adhesions 14.03 10.15 64 678818 3509 79061997
Tumour haemorrhage 13.99 10.15 9 678873 4135 79061371
Placental disorder 13.98 10.15 27 678855 906 79064600
Walking aid user 13.98 10.15 140 678742 10008 79055498
Cellulitis 13.97 10.15 1094 677788 107966 78957540
Alcohol abuse 13.96 10.15 15 678867 5348 79060158
Foetal distress syndrome 13.92 10.15 19 678863 473 79065033
Osteoporotic fracture 13.81 10.15 72 678810 4168 79061338
Amylase increased 13.77 10.15 49 678833 11160 79054346
Atrioventricular block 13.75 10.15 67 678815 13974 79051532
Sinus congestion 13.73 10.15 242 678640 19654 79045852
Aphthous ulcer 13.72 10.15 211 678671 16678 79048828
Ankle arthroplasty 13.70 10.15 36 678846 1489 79064017
Acoustic neuroma 13.66 10.15 15 678867 296 79065210
Drug dose omission by device 13.64 10.15 20 678862 6230 79059276
Short stature 13.62 10.15 23 678859 694 79064812
Musculoskeletal discomfort 13.59 10.15 241 678641 19594 79045912
Accidental exposure to product by child 13.59 10.15 4 678878 2922 79062584
Joint lock 13.59 10.15 59 678823 3166 79062340
Eyelid oedema 13.58 10.15 65 678817 13622 79051884
Faeces soft 13.56 10.15 119 678763 8204 79057302
Sickle cell anaemia 13.55 10.15 22 678860 642 79064864
Blood pressure decreased 13.54 10.15 700 678182 98766 78966740
Dyslipidaemia 13.54 10.15 52 678830 11581 79053925
Ligament rupture 13.48 10.15 61 678821 3333 79062173
Diaphragmatic disorder 13.43 10.15 39 678843 1711 79063795
Onychomycosis 13.40 10.15 118 678764 8143 79057363
Spinal disorder 13.40 10.15 140 678742 10120 79055386
Acute myeloid leukaemia recurrent 13.39 10.15 6 678876 3377 79062129
Dermatitis bullous 13.36 10.15 69 678813 14176 79051330
Maternal exposure during breast feeding 13.34 10.15 53 678829 2732 79062774
Metastases to meninges 13.32 10.15 7 678875 3594 79061912
Eosinophil count increased 13.30 10.15 88 678794 17017 79048489
Linear IgA disease 13.29 10.15 5 678877 3127 79062379
Autoimmune disorder 13.29 10.15 207 678675 16405 79049101
Neutrophilia 13.28 10.15 30 678852 7921 79057585
Myringotomy 13.20 10.15 6 678876 24 79065482
Body height below normal 13.19 10.15 43 678839 2010 79063496
Oxygen saturation decreased 13.19 10.15 1273 677609 127774 78937732
Intestinal ischaemia 13.18 10.15 63 678819 13207 79052299
Leukoencephalopathy 13.17 10.15 30 678852 7899 79057607
Lymph gland infection 13.10 10.15 20 678862 553 79064953
Acute lung injury 13.07 10.15 5 678877 3095 79062411
Tooth fracture 13.07 10.15 153 678729 11377 79054129
Normal newborn 13.06 10.15 104 678778 6968 79058538
Pleuritic pain 13.01 10.15 138 678744 10014 79055492
Benign abdominal neoplasm 12.92 10.15 14 678868 272 79065234
Prescribed underdose 12.92 10.15 336 678546 29178 79036328
Hypertensive crisis 12.78 10.15 114 678768 20656 79044850
Induced labour 12.78 10.15 25 678857 847 79064659
Activated partial thromboplastin time prolonged 12.74 10.15 70 678812 14158 79051348
Hypoglycaemic coma 12.74 10.15 13 678869 4747 79060759
Delayed graft function 12.70 10.15 7 678875 3500 79062006
Aspiration 12.69 10.15 110 678772 20048 79045458
Polydipsia 12.67 10.15 23 678859 6582 79058924
Urinary retention 12.65 10.15 376 678506 56254 79009252
Cryptococcosis 12.61 10.15 7 678875 3486 79062020
Lip swelling 12.58 10.15 259 678623 40652 79024854
Pernicious anaemia 12.51 10.15 20 678862 576 79064930
Hyperlipidaemia 12.47 10.15 152 678730 25941 79039565
Skin laceration 12.47 10.15 329 678553 28633 79036873
Back disorder 12.41 10.15 152 678730 11426 79054080
Vascular rupture 12.40 10.15 37 678845 1648 79063858
Mixed liver injury 12.33 10.15 29 678853 7549 79057957
Metastasis 12.29 10.15 25 678857 6855 79058651
Joint warmth 12.28 10.15 36 678846 1588 79063918
Hypotonia 12.27 10.15 62 678820 12808 79052698
Retinal haemorrhage 12.16 10.15 33 678849 8184 79057322
Menstruation delayed 12.14 10.15 33 678849 1393 79064113
Radiation inflammation 12.13 10.15 25 678857 880 79064626
Vitamin B complex deficiency 12.13 10.15 23 678859 761 79064745
Glomerular filtration rate decreased 12.12 10.15 129 678753 22573 79042933
Abscess intestinal 12.11 10.15 51 678831 2700 79062806
Musculoskeletal disorder 12.11 10.15 253 678629 21195 79044311
Drug tolerance 12.11 10.15 120 678762 8555 79056951
Precancerous skin lesion 12.10 10.15 32 678850 1329 79064177
Benign ovarian tumour 12.05 10.15 15 678867 340 79065166
Anaemia vitamin B12 deficiency 12.05 10.15 23 678859 765 79064741
Upper respiratory tract inflammation 12.01 10.15 10 678872 4025 79061481
Inadequate analgesia 11.99 10.15 13 678869 4616 79060890
Anticholinergic syndrome 11.97 10.15 8 678874 3603 79061903
Right ventricular failure 11.95 10.15 135 678747 23362 79042144
Wrong patient received product 11.93 10.15 13 678869 4605 79060901
Skin injury 11.91 10.15 59 678823 3347 79062159
Therapeutic product effect incomplete 11.90 10.15 1379 677503 140266 78925240
Conduction disorder 11.87 10.15 7 678875 3372 79062134
Ileus paralytic 11.85 10.15 42 678840 9578 79055928
Dependence 11.84 10.15 3 678879 2419 79063087
Dyspnoea at rest 11.83 10.15 28 678854 7274 79058232
Rash erythematous 11.83 10.15 388 678494 57381 79008125
Proctitis 11.81 10.15 23 678859 6409 79059097
Viral infection 11.80 10.15 463 678419 42553 79022953
Dehydration 11.79 10.15 1894 676988 246293 78819213
Laryngospasm 11.78 10.15 10 678872 3987 79061519
Gastrointestinal stoma complication 11.70 10.15 49 678833 2588 79062918
Acrochordon 11.62 10.15 27 678855 1033 79064473
Lung transplant 11.61 10.15 13 678869 4548 79060958
Immunosuppression 11.60 10.15 163 678719 12640 79052866
Vision blurred 11.59 10.15 761 678121 105137 78960369
Nerve compression 11.56 10.15 125 678757 9114 79056392
Drug ineffective 11.52 10.15 9663 669219 1071250 77994256
Squamous cell carcinoma 11.50 10.15 192 678690 15430 79050076
Inflammatory bowel disease 11.49 10.15 85 678797 5566 79059940
Personality change 11.49 10.15 46 678836 10124 79055382
Tooth abscess 11.48 10.15 198 678684 16012 79049494
Stress 11.45 10.15 806 678076 78806 78986700
Appendicectomy 11.37 10.15 50 678832 2698 79062808
Lipodystrophy acquired 11.37 10.15 12 678870 4313 79061193
Capillary leak syndrome 11.35 10.15 10 678872 3915 79061591
Vasa praevia 11.32 10.15 3 678879 0 79065506
Keratorhexis 11.32 10.15 3 678879 0 79065506
Red blood cell count 11.32 10.15 3 678879 0 79065506
Ischaemic cardiomyopathy 11.32 10.15 31 678851 7664 79057842
Pelvic fracture 11.31 10.15 156 678726 12048 79053458
Neuropathy peripheral 11.30 10.15 1042 677840 140263 78925243
Product quality issue 11.30 10.15 212 678670 33728 79031778
Rash morbilliform 11.28 10.15 22 678860 6128 79059378
Hiatus hernia 11.27 10.15 269 678613 23043 79042463
Skin abrasion 11.27 10.15 169 678713 13287 79052219
On and off phenomenon 11.24 10.15 56 678826 3184 79062322
Lipase increased 11.21 10.15 88 678794 16378 79049128
Antipsychotic drug level increased 11.20 10.15 21 678861 5936 79059570
Humerus fracture 11.20 10.15 125 678757 9188 79056318
Lip blister 11.19 10.15 50 678832 2717 79062789
Infected bite 11.14 10.15 39 678843 1891 79063615
Adverse drug reaction 11.13 10.15 681 678201 65711 78999795
Small intestinal stenosis 11.12 10.15 23 678859 812 79064694
Autoimmune hepatitis 11.10 10.15 57 678825 11726 79053780
Cardiopulmonary failure 11.08 10.15 26 678856 6775 79058731
Road traffic accident 11.06 10.15 466 678416 43198 79022308
Laryngeal oedema 11.04 10.15 34 678848 8095 79057411
Chest discomfort 11.04 10.15 1018 677864 137026 78928480
Renal cancer 11.03 10.15 60 678822 12166 79053340
Pneumomediastinum 11.02 10.15 9 678873 3658 79061848
Rhinovirus infection 10.99 10.15 33 678849 7920 79057586
Secondary adrenocortical insufficiency 10.94 10.15 6 678876 3008 79062498
Nausea 10.92 10.15 7733 671149 949463 78116043
Oligoarthritis 10.91 10.15 21 678861 703 79064803
Hepatosplenomegaly 10.88 10.15 22 678860 6047 79059459
Intestinal obstruction 10.87 10.15 459 678423 42561 79022945
Neutropenic colitis 10.83 10.15 20 678862 5687 79059819
Nervous system disorder 10.82 10.15 162 678720 26694 79038812
Viral upper respiratory tract infection 10.78 10.15 121 678761 8905 79056601
Nightmare 10.77 10.15 155 678727 25706 79039800
Vitamin B6 deficiency 10.77 10.15 14 678868 332 79065174
Colitis microscopic 10.77 10.15 51 678831 10717 79054789
Clavicle fracture 10.75 10.15 69 678813 4312 79061194
Neoplasm recurrence 10.73 10.15 12 678870 4202 79061304
Fungaemia 10.71 10.15 14 678868 4577 79060929
Cyst rupture 10.71 10.15 20 678862 654 79064852
Spondylitis 10.69 10.15 73 678809 4658 79060848
Thirst 10.68 10.15 104 678778 18515 79046991
Hypopituitarism 10.65 10.15 8 678874 3391 79062115
Erectile dysfunction 10.63 10.15 77 678805 14587 79050919
C-reactive protein decreased 10.63 10.15 48 678834 2620 79062886
Meniscus injury 10.63 10.15 96 678786 6672 79058834
Generalised oedema 10.63 10.15 140 678742 23569 79041937
Back pain 10.61 10.15 2827 676055 301353 78764153
Mental disorder 10.59 10.15 195 678687 31107 79034399
Fixed eruption 10.55 10.15 6 678876 2948 79062558
Lymphatic fistula 10.55 10.15 22 678860 781 79064725
Dactylitis 10.54 10.15 49 678833 2708 79062798
Cartilage injury 10.53 10.15 33 678849 1510 79063996
Threatened labour 10.53 10.15 19 678863 605 79064901
Magnesium deficiency 10.53 10.15 19 678863 605 79064901
Enterococcal infection 10.52 10.15 84 678798 15576 79049930
Systemic inflammatory response syndrome 10.49 10.15 56 678826 11409 79054097
Clonus 10.48 10.15 27 678855 6813 79058693
Wound infection pseudomonas 10.46 10.15 34 678848 1587 79063919
Peripheral motor neuropathy 10.46 10.15 8 678874 3359 79062147
Sensory loss 10.44 10.15 162 678720 12829 79052677
Intra-abdominal haemorrhage 10.43 10.15 14 678868 4526 79060980
Drug withdrawal convulsions 10.38 10.15 3 678879 2217 79063289
Haemorrhage in pregnancy 10.36 10.15 31 678851 1383 79064123
Staphylococcal sepsis 10.35 10.15 78 678804 14648 79050858
Bradyarrhythmia 10.35 10.15 12 678870 4134 79061372
Psychotic symptom 10.34 10.15 5 678877 2692 79062814
Coronary artery stenosis 10.34 10.15 63 678819 12421 79053085
Cerebellar haemorrhage 10.33 10.15 6 678876 2914 79062592
Renal infarct 10.30 10.15 5 678877 2686 79062820
Aplastic anaemia 10.28 10.15 100 678782 17805 79047701
Paraesthesia oral 10.26 10.15 118 678764 20353 79045153
Rhinitis allergic 10.24 10.15 154 678728 12115 79053391
Tongue oedema 10.22 10.15 29 678853 7088 79058418
Haemodialysis 10.21 10.15 102 678780 18066 79047440
Mitochondrial toxicity 10.19 10.15 7 678875 3107 79062399
Accessory spleen 10.18 10.15 11 678871 213 79065293
Metamyelocyte count increased 10.18 10.15 19 678863 621 79064885
Dry mouth 10.16 10.15 876 678006 87143 78978363
Defaecation disorder 10.16 10.15 20 678862 681 79064825

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B03AE01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
ATC B03BA01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Vitamin B12 (cyanocobalamin and analogues)
ATC B03BA51 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Vitamin B12 (cyanocobalamin and analogues)
FDA CS M0022794 Vitamin B 12
FDA EPC N0000175951 Vitamin B12
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:33229 vitamins

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pernicious anemia indication 84027009 DOID:13381
Megaloblastic anemia due to folate deficiency indication 85649008 DOID:14026
Vitamin deficiency indication 85670002
Iron deficiency anemia indication 87522002
Cobalamin deficiency indication 190634004
Prevention of Vitamin B12 Deficiency indication
Vitamin Deficiency Prevention indication
Homocystinuria off-label use 11282001 DOID:9263
Methylmalonic acidemia off-label use 42393006
Homocystinemia off-label use 52311001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.5MG/SPRAY NASCOBAL ENDO PHARMS INC N021642 Jan. 31, 2005 RX SPRAY, METERED NASAL 8940714 Feb. 26, 2024 CYANOCOBALAMIN ADMINISTRATION THROUGH NASAL INFUSION
0.5MG/SPRAY NASCOBAL ENDO PHARMS INC N021642 Jan. 31, 2005 RX SPRAY, METERED NASAL 9415007 July 28, 2024 SUPPLEMENT FOR VITAMIN B12 DEFICIENCIES
0.5MG/SPRAY NASCOBAL ENDO PHARMS INC N021642 Jan. 31, 2005 RX SPRAY, METERED NASAL 7229636 Aug. 1, 2024 NASAL ADMINISTRATION OF CYANOCOBALAMIN
0.5MG/SPRAY NASCOBAL ENDO PHARMS INC N021642 Jan. 31, 2005 RX SPRAY, METERED NASAL 7879349 Aug. 1, 2024 CYANOCOBALAMIN ADMINISTRATION THROUGH NASAL INFUSION
0.5MG/SPRAY NASCOBAL ENDO PHARMS INC N021642 Jan. 31, 2005 RX SPRAY, METERED NASAL 8003353 Aug. 1, 2024 NASAL ADMINISTRATION OF CYANOCOBALAMIN

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Methionine synthase Enzyme WOMBAT-PK
Methionine synthase reductase Enzyme WOMBAT-PK
Protein amnionless Unclassified WOMBAT-PK
Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial Enzyme WOMBAT-PK
Methylmalonic aciduria type A protein, mitochondrial Enzyme WOMBAT-PK
Transcobalamin-2 Secreted WOMBAT-PK
Transcobalamin-1 Secreted WOMBAT-PK

External reference:

IDSource
4021085 VUID
N0000148543 NUI
D00166 KEGG_DRUG
4017441 VANDF
4017907 VANDF
4021085 VANDF
4021896 VANDF
C0042845 UMLSCUI
CHEBI:17439 CHEBI
CNC PDB_CHEM_ID
CHEMBL2110563 ChEMBL_ID
CHEMBL2375172 ChEMBL_ID
DB00115 DRUGBANK_ID
1369 INN_ID
P6YC3EG204 UNII
5311498 PUBCHEM_CID
11248 RXNORM
213062 MMSL
257021 MMSL
4514 MMSL
5682 MMSL
6832 MMSL
6837 MMSL
8312 MMSL
d00413 MMSL
001043 NDDF
30010009 SNOMEDCT_US
304111003 SNOMEDCT_US
419382002 SNOMEDCT_US
D014805 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9619 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9619 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9619 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9620 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9620 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9620 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9621 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9621 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9621 INJECTION 1000 ug INTRAMUSCULAR ANDA 21 sections
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 12 ug ORAL unapproved drug other 17 sections
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 12 ug ORAL unapproved drug other 17 sections
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 12 ug ORAL Unapproved drug other 12 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 16.80 ug ORAL unapproved drug other 15 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 16.80 ug ORAL unapproved drug other 15 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 16.80 ug ORAL unapproved drug other 15 sections
CYANOCOBALAMIN HUMAN PRESCRIPTION DRUG LABEL 1 0404-9840 INJECTION 1000 ug INTRAMUSCULAR ANDA 11 sections
CYANOCOBALAMIN HUMAN PRESCRIPTION DRUG LABEL 1 0404-9840 INJECTION 1000 ug INTRAMUSCULAR ANDA 11 sections
CYANOCOBALAMIN HUMAN PRESCRIPTION DRUG LABEL 1 0404-9840 INJECTION 1000 ug INTRAMUSCULAR ANDA 11 sections
CYANOCOBALAMINE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9995 INJECTION 1000 ug INTRAMUSCULAR ANDA 11 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0517-0031 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 19 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0517-0031 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 19 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0517-0032 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 19 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0517-0032 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 19 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0517-0130 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 19 sections
Cyanocobalamin HUMAN PRESCRIPTION DRUG LABEL 1 0517-0130 INJECTION, SOLUTION 1000 ug INTRAMUSCULAR ANDA 19 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 0.01 mg ORAL unapproved drug other 14 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 5 ug ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 12 ug ORAL Unapproved drug other 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 12 ug ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 12 ug ORAL UNAPPROVED DRUG OTHER 13 sections