alpha-tocopherol acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4195 58-95-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alpha-tocopherol acetate
  • Vitamin E acetate
  • (+)-alpha-tocopherol acetate
  • alfacol
  • contopheron
  • D-alpha-Tocopherol acetate
  • .alpha.-tocopherol acetate, dl-
  • .ALPHA.-TOCOPHEROL ACETATE, D-
  • .ALPHA.-TOCOPHEROL ACETATE
  • alpha-tocopherol acetate, dl-
  • tocopherol acetate
  • Molecular weight: 472.75
  • Formula: C31H52O3
  • CLOGP: 12
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 0
  • TPSA: 35.53
  • ALOGS: -8.21
  • ROTB: 14
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 18, 2000 FDA SANDOZ

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1685.54 10.31 4403 543760 179323 62761536
Systemic lupus erythematosus 1588.53 10.31 4675 543488 204243 62736616
Glossodynia 1402.73 10.31 4048 544115 174828 62766031
Hand deformity 1141.83 10.31 3495 544668 155962 62784897
Arthropathy 1047.61 10.31 4407 543756 230385 62710474
Abdominal discomfort 957.23 10.31 5365 542798 315520 62625339
Alopecia 943.89 10.31 5547 542616 331989 62608870
Wound 942.20 10.31 3326 544837 159937 62780922
Maternal exposure during pregnancy 842.49 10.31 3947 544216 216115 62724744
Rheumatoid arthritis 832.95 10.31 4357 543806 249462 62691397
Synovitis 742.83 10.31 3390 544773 183528 62757331
Anti-cyclic citrullinated peptide antibody positive 714.01 10.31 2418 545745 113794 62827065
Pericarditis 707.38 10.31 2620 545543 128959 62811900
Discomfort 695.30 10.31 3076 545087 164298 62776561
Swelling 680.34 10.31 4385 543778 270993 62669866
Contraindicated product administered 675.41 10.31 3680 544483 213968 62726891
Infusion related reaction 646.40 10.31 3974 544189 241547 62699312
Joint swelling 605.29 10.31 4865 543298 322801 62618058
Pain 514.20 10.31 9106 539057 731522 62209337
Duodenal ulcer perforation 448.05 10.31 1712 546451 85497 62855362
Rheumatoid factor positive 438.59 10.31 1663 546500 82743 62858116
Helicobacter infection 434.33 10.31 1769 546394 91016 62849843
Product use issue 424.57 10.31 3307 544856 217213 62723646
Hepatic enzyme increased 384.33 10.31 3025 545138 199303 62741556
Completed suicide 349.42 10.31 2304 545859 143369 62797490
Febrile neutropenia 339.56 10.31 313 547850 118136 62822723
Arthralgia 327.55 10.31 6810 541353 562900 62377959
Drug interaction 324.39 10.31 961 547202 228170 62712689
Psoriatic arthropathy 323.12 10.31 1605 546558 89915 62850944
Musculoskeletal stiffness 302.34 10.31 2670 545493 181948 62758911
Death 299.91 10.31 1947 546216 372434 62568425
Therapeutic product effect decreased 291.02 10.31 2744 545419 190443 62750416
Exposure during pregnancy 278.02 10.31 2294 545869 153253 62787606
Drug intolerance 268.13 10.31 3943 544220 304718 62636141
Acute kidney injury 260.03 10.31 1279 546884 262136 62678723
Malignant neoplasm progression 235.32 10.31 217 547946 81904 62858955
Treatment failure 234.71 10.31 2690 545473 196353 62744506
Hip arthroplasty 232.09 10.31 920 547243 46726 62894133
Disease progression 225.59 10.31 449 547714 122309 62818550
Knee arthroplasty 225.25 10.31 997 547166 53209 62887650
Neutropenia 210.46 10.31 788 547375 174217 62766642
Constipation 197.53 10.31 1136 547027 223807 62717052
Rheumatic fever 196.12 10.31 815 547348 42296 62898563
Hypersensitivity 195.72 10.31 3582 544581 289103 62651756
Impaired healing 184.56 10.31 1515 546648 101027 62839832
Hyponatraemia 174.86 10.31 447 547716 111453 62829406
Nausea 173.67 10.31 5845 542318 848626 62092233
Swollen joint count increased 171.44 10.31 691 547472 35363 62905496
Diarrhoea 169.01 10.31 4796 543367 710570 62230289
Nasopharyngitis 167.92 10.31 3106 545057 251151 62689708
Bradycardia 163.82 10.31 236 547927 72991 62867868
Red blood cell sedimentation rate abnormal 156.82 10.31 450 547713 19332 62921527
Depressed level of consciousness 156.44 10.31 183 547980 61895 62878964
Folliculitis 155.21 10.31 1090 547073 69227 62871632
Muscle injury 151.97 10.31 1026 547137 64319 62876540
Drug hypersensitivity 149.11 10.31 1841 546322 308846 62632013
Blister 146.91 10.31 1741 546422 128073 62812786
Asthenia 145.34 10.31 2383 545780 381221 62559638
Sedation 144.90 10.31 77 548086 38732 62902127
Dyspnoea 142.08 10.31 4490 543673 656823 62284036
Drug reaction with eosinophilia and systemic symptoms 140.42 10.31 58 548105 33778 62907081
Renal failure 138.63 10.31 534 547629 117118 62823741
Cardiac failure 137.79 10.31 358 547805 88784 62852075
Sickle cell anaemia with crisis 135.67 10.31 210 547953 5793 62935066
Sleep disorder due to general medical condition, insomnia type 134.32 10.31 841 547322 51376 62889483
Liver injury 129.41 10.31 931 547232 59589 62881270
Neoplasm progression 129.21 10.31 77 548086 36351 62904508
Alcohol interaction 129.05 10.31 130 548033 2279 62938580
Lactic acidosis 124.84 10.31 89 548074 38198 62902661
Irritable bowel syndrome 123.60 10.31 1170 546993 81242 62859617
Hyperhidrosis 121.62 10.31 498 547665 107338 62833521
Thrombocytopenia 118.76 10.31 790 547373 150367 62790492
C-reactive protein abnormal 118.31 10.31 742 547421 45354 62895505
Tremor 117.51 10.31 665 547498 131574 62809285
Anaemia 115.99 10.31 1808 546355 291622 62649237
Anxiety 115.97 10.31 1259 546904 216282 62724577
Fatigue 114.08 10.31 9017 539146 879011 62061848
Electrocardiogram QT prolonged 110.81 10.31 216 547947 59314 62881545
Hypotension 110.34 10.31 1672 546491 270932 62669927
Rash 110.30 10.31 5907 542256 554964 62385895
Lower respiratory tract infection 107.53 10.31 1672 546491 130635 62810224
Vomiting 107.02 10.31 3855 544308 555762 62385097
Blood cholesterol increased 105.42 10.31 1259 546904 92773 62848086
Renal impairment 105.38 10.31 399 547764 87956 62852903
Rhabdomyolysis 103.97 10.31 136 548027 43815 62897044
No adverse event 98.07 10.31 128 548035 41277 62899582
Syncope 98.07 10.31 602 547561 116783 62824076
Osteoarthritis 98.02 10.31 1256 546907 94087 62846772
Pregnancy 95.18 10.31 594 547569 36242 62904617
Intentional product use issue 94.14 10.31 1590 546573 126302 62814557
Type 2 diabetes mellitus 93.91 10.31 903 547260 62965 62877894
Asthma 91.22 10.31 685 547478 126876 62813983
Multiple sclerosis relapse 90.14 10.31 176 547987 48302 62892557
Arthritis 88.19 10.31 1449 546714 114472 62826387
Cognitive disorder 87.90 10.31 222 547941 55593 62885266
Dizziness 86.81 10.31 2941 545222 426984 62513875
Drug resistance 86.35 10.31 45 548118 22888 62917971
Orthostatic hypotension 85.42 10.31 112 548051 36048 62904811
Hyperglycaemia 84.99 10.31 144 548019 41723 62899136
Respiratory failure 84.75 10.31 523 547640 101335 62839524
Fibromyalgia 84.61 10.31 1064 547099 79356 62861503
Sedation complication 84.56 10.31 10 548153 13812 62927047
Angioedema 84.20 10.31 180 547983 47785 62893074
Neuropathy peripheral 82.89 10.31 607 547556 113060 62827799
Psoriasis 82.10 10.31 1128 547035 85829 62855030
Live birth 81.01 10.31 436 547727 25194 62915665
Myalgia 80.07 10.31 843 547320 145686 62795173
Hepatic function abnormal 78.90 10.31 124 548039 37018 62903841
Drug ineffective for unapproved indication 77.94 10.31 108 548055 33955 62906904
Blood glucose increased 77.77 10.31 415 547748 83341 62857518
Condition aggravated 77.27 10.31 4228 543935 397989 62542870
Dehydration 76.85 10.31 1044 547119 172310 62768549
Abortion spontaneous 76.80 10.31 682 547481 46513 62894346
Cardiac failure congestive 76.69 10.31 475 547688 91958 62848901
Hypoglycaemia 76.41 10.31 264 547899 59801 62881058
Vision blurred 75.95 10.31 473 547690 91451 62849408
Product quality issue 75.93 10.31 120 548043 35745 62905114
Device expulsion 74.74 10.31 116 548047 34806 62906053
Hyperkalaemia 74.66 10.31 230 547933 53973 62886886
Serotonin syndrome 73.93 10.31 83 548080 28599 62912260
Neutrophil count decreased 73.74 10.31 245 547918 56161 62884698
Cytomegalovirus infection 73.31 10.31 45 548118 20907 62919952
Joint effusion 73.29 10.31 317 547846 16743 62924116
Palmar-plantar erythrodysaesthesia syndrome 73.08 10.31 55 548108 22960 62917899
Creatinine renal clearance decreased 72.60 10.31 25 548138 16283 62924576
Leukopenia 72.30 10.31 382 547781 76908 62863951
Ill-defined disorder 72.15 10.31 1048 547115 80707 62860152
Cholestasis 71.78 10.31 89 548074 29345 62911514
Chest discomfort 71.47 10.31 606 547557 109363 62831496
COVID-19 70.96 10.31 629 547534 112474 62828385
Anaphylactic reaction 70.36 10.31 312 547851 65788 62875071
Tachycardia 70.27 10.31 666 547497 117490 62823369
Metastases to bone 69.66 10.31 48 548115 20971 62919888
Blood pressure diastolic abnormal 69.35 10.31 279 547884 14263 62926596
Myocardial infarction 69.25 10.31 541 547622 99352 62841507
Blood pressure fluctuation 69.14 10.31 657 547506 45660 62895199
Blood pressure systolic abnormal 68.84 10.31 263 547900 13123 62927736
Contusion 68.38 10.31 1738 546425 148306 62792553
Balance disorder 67.90 10.31 438 547725 83984 62856875
Hepatocellular injury 67.60 10.31 82 548081 27299 62913560
Product use in unapproved indication 67.48 10.31 1113 547050 177967 62762892
Peripheral swelling 67.14 10.31 2872 545291 263070 62677789
White blood cell count decreased 65.58 10.31 827 547336 138277 62802582
Multiple organ dysfunction syndrome 65.28 10.31 260 547903 56492 62884367
Feeling abnormal 65.28 10.31 895 547268 147497 62793362
Red blood cell sedimentation rate increased 65.22 10.31 623 547540 43359 62897500
Osteonecrosis of jaw 64.88 10.31 128 548035 34995 62905864
Disability assessment scale score increased 64.70 10.31 107 548056 3126 62937733
Cardiac arrest 63.32 10.31 503 547660 92042 62848817
Somnolence 62.66 10.31 1125 547038 177560 62763299
Hypoxia 60.80 10.31 287 547876 59505 62881354
Insomnia 60.66 10.31 1405 546758 213847 62727012
Cytokine release syndrome 60.26 10.31 24 548139 14290 62926569
Anaphylactic shock 60.25 10.31 69 548094 23564 62917295
Foot deformity 59.82 10.31 429 547734 27424 62913435
Sopor 59.50 10.31 62 548101 22102 62918757
Blood calcium decreased 59.39 10.31 85 548078 26366 62914493
Diabetic ketoacidosis 58.94 10.31 54 548109 20451 62920408
Platelet count decreased 58.29 10.31 681 547482 115441 62825418
Hallucination 57.58 10.31 260 547903 54557 62886302
Basal cell carcinoma 55.49 10.31 423 547740 27568 62913291
Metabolic acidosis 55.38 10.31 201 547962 44868 62895991
Alcohol poisoning 54.82 10.31 75 548088 1844 62939015
Sinusitis 54.80 10.31 2437 545726 224216 62716643
Sepsis 54.01 10.31 963 547200 152160 62788699
Hypokalaemia 53.96 10.31 604 547559 103200 62837659
Drug ineffective 53.83 10.31 10015 538148 1034750 61906109
Juvenile idiopathic arthritis 53.49 10.31 100 548063 3226 62937633
Wrong technique in product usage process 53.47 10.31 317 547846 62023 62878836
Agitation 53.32 10.31 300 547863 59457 62881402
Ejection fraction decreased 52.92 10.31 69 548094 22263 62918596
Dysphagia 52.80 10.31 499 547664 88086 62852773
Grip strength decreased 52.43 10.31 351 547812 21936 62918923
Metastases to liver 52.05 10.31 77 548086 23562 62917297
Pulmonary embolism 51.94 10.31 702 547461 115982 62824877
Hepatic failure 51.48 10.31 148 548015 35508 62905351
Drug abuse 51.31 10.31 896 547267 71622 62869237
Blood pressure systolic increased 51.09 10.31 630 547533 46767 62894092
Altered state of consciousness 51 10.31 87 548076 25143 62915716
Cerebral haemorrhage 50.92 10.31 119 548044 30610 62910249
Gamma-glutamyltransferase increased 50.80 10.31 139 548024 33892 62906967
Pulmonary fibrosis 49.99 10.31 545 547618 39264 62901595
Joint laxity 49.91 10.31 82 548081 2382 62938477
Disturbance in attention 49.83 10.31 166 547997 38023 62902836
Bone erosion 49.77 10.31 292 547871 17425 62923434
Palpitations 49.64 10.31 680 547483 112090 62828769
Emotional distress 48.55 10.31 133 548030 32416 62908443
Ascites 48.50 10.31 184 547979 40544 62900315
Posterior reversible encephalopathy syndrome 48.30 10.31 47 548116 17298 62923561
Osteoporosis 48.23 10.31 729 547434 56609 62884250
Injection site erythema 47.99 10.31 996 547167 82178 62858681
Inappropriate antidiuretic hormone secretion 47.76 10.31 38 548125 15424 62925435
Chronic kidney disease 47.28 10.31 216 547947 45182 62895677
Urticaria 47.04 10.31 1081 547082 164721 62776138
Blood pressure decreased 47.02 10.31 348 547815 64674 62876185
Fluid retention 46.80 10.31 312 547851 59374 62881485
Caesarean section 46.75 10.31 279 547884 16753 62924106
Joint destruction 46.46 10.31 139 548024 6113 62934746
Speech disorder 46.18 10.31 187 547976 40442 62900417
Disseminated intravascular coagulation 46.04 10.31 58 548105 18993 62921866
Joint range of motion decreased 45.95 10.31 455 547708 31973 62908886
Stomatitis 45.93 10.31 1544 546619 137181 62803678
Decreased appetite 45.87 10.31 1738 546425 249314 62691545
Myelosuppression 45.86 10.31 84 548079 23619 62917240
Cardio-respiratory arrest 45.39 10.31 749 547414 59210 62881649
Foetal exposure during pregnancy 45.06 10.31 448 547715 31514 62909345
Respiratory disorder 44.97 10.31 179 547984 38903 62901956
Pyrexia 44.64 10.31 3477 544686 467001 62473858
Disorientation 44.58 10.31 182 547981 39270 62901589
Encephalopathy 44.37 10.31 177 547986 38443 62902416
Off label use 44.23 10.31 5124 543039 669338 62271521
Muscle spasticity 44.19 10.31 75 548088 21719 62919140
Suspected suicide 44.14 10.31 141 548022 6427 62934432
Device difficult to use 44.05 10.31 28 548135 12768 62928091
Drug tolerance decreased 44.04 10.31 280 547883 17193 62923666
Neurotoxicity 43.97 10.31 49 548114 16941 62923918
Cerebrovascular accident 43.82 10.31 662 547501 107362 62833497
Intentional self-injury 43.76 10.31 98 548065 25589 62915270
Bone pain 43.67 10.31 284 547879 54357 62886502
Polyneuropathy 43.64 10.31 37 548126 14552 62926307
Alcohol use 43.22 10.31 70 548093 2009 62938850
Vertigo 43.07 10.31 321 547842 59566 62881293
Infection 42.92 10.31 2404 545759 226769 62714090
C-reactive protein increased 42.82 10.31 1096 547067 93611 62847248
Hospitalisation 42.67 10.31 499 547664 84582 62856277
Inflammation 42.30 10.31 969 547194 81304 62859555
Torsade de pointes 42.27 10.31 32 548131 13319 62927540
Disease recurrence 42.21 10.31 114 548049 27916 62912943
Extrapyramidal disorder 41.85 10.31 32 548131 13252 62927607
Flushing 41.80 10.31 430 547733 74657 62866202
Parkinsonism 41.56 10.31 19 548144 10420 62930439
Weight increased 41.39 10.31 2696 545467 258096 62682763
Pain in jaw 41.21 10.31 214 547949 43282 62897577
Haemorrhage 41.12 10.31 333 547830 60689 62880170
Blood pressure diastolic decreased 41.09 10.31 336 547827 22370 62918489
Polyarthritis 40.91 10.31 185 547978 9961 62930898
Blood creatinine increased 40.36 10.31 525 547638 87319 62853540
Agranulocytosis 40.32 10.31 99 548064 25035 62915824
Eosinophilia 40.27 10.31 85 548078 22671 62918188
Acute generalised exanthematous pustulosis 40.01 10.31 23 548140 11076 62929783
Diabetes mellitus inadequate control 39.84 10.31 43 548120 15083 62925776
Blood alkaline phosphatase increased 39.82 10.31 213 547950 42754 62898105
Dyskinesia 39.80 10.31 142 548021 31860 62908999
Schizophrenia 39.79 10.31 18 548145 9934 62930925
Blood bilirubin increased 39.70 10.31 175 547988 36965 62903894
Seizure 39.53 10.31 858 547305 131776 62809083
Thrombotic microangiopathy 39.35 10.31 21 548142 10540 62930319
Gastrointestinal haemorrhage 39.22 10.31 480 547683 80696 62860163
Gestational diabetes 39.17 10.31 160 548003 8236 62932623
Injection site reaction 38.89 10.31 716 547447 57808 62883051
Loss of personal independence in daily activities 38.61 10.31 1107 547056 96183 62844676
Disability 38.49 10.31 281 547882 18066 62922793
Metastases to central nervous system 38.28 10.31 34 548129 13071 62927788
Dysgeusia 38.23 10.31 241 547922 46469 62894390
Toxic skin eruption 38.15 10.31 33 548130 12852 62928007
Neuroleptic malignant syndrome 38.04 10.31 29 548134 12027 62928832
Blood creatine phosphokinase increased 37.86 10.31 135 548028 30295 62910564
Dystonia 37.84 10.31 38 548125 13781 62927078
Premature labour 37.69 10.31 210 547953 12294 62928565
Second primary malignancy 37.52 10.31 11 548152 7942 62932917
Respiratory distress 37.50 10.31 158 548005 33793 62907066
Haematotoxicity 37.43 10.31 17 548146 9359 62931500
Injection site pruritus 37.32 10.31 572 547591 44544 62896315
Product dose omission issue 37.06 10.31 1649 546514 232664 62708195
Neck deformity 36.93 10.31 66 548097 2055 62938804
Mental status changes 36.86 10.31 196 547967 39403 62901456
Restlessness 36.42 10.31 131 548032 29322 62911537
Stress cardiomyopathy 36.39 10.31 18 548145 9432 62931427
Rheumatoid nodule 36.13 10.31 263 547900 16892 62923967
Chest pain 35.99 10.31 1511 546652 214448 62726411
Accidental exposure to product 35.84 10.31 119 548044 27286 62913573
Hemiparesis 35.58 10.31 94 548069 23188 62917671
Multiple fractures 35.39 10.31 158 548005 8460 62932399
Transplant rejection 35.22 10.31 25 548138 10755 62930104
Back pain 35.12 10.31 1893 546270 262252 62678607
Dyspnoea exertional 34.95 10.31 342 547821 59960 62880899
Pancreatitis acute 34.82 10.31 119 548044 27047 62913812
Pulmonary arterial hypertension 34.62 10.31 91 548072 22486 62918373
Depression 34.40 10.31 1367 546796 195125 62745734
Tuberculosis 34.27 10.31 189 547974 11022 62929837
Hypomagnesaemia 34.10 10.31 130 548033 28607 62912252
Psychotic disorder 34.07 10.31 111 548052 25601 62915258
Lymphocyte count decreased 33.92 10.31 140 548023 30117 62910742
Maternal drugs affecting foetus 33.84 10.31 111 548052 5131 62935728
Bronchospasm 33.65 10.31 61 548102 17219 62923640
Drug withdrawal syndrome 33.59 10.31 121 548042 27073 62913786
Shock 33.43 10.31 98 548065 23365 62917494
Atrioventricular block complete 32.87 10.31 15 548148 8236 62932623
Obstructive airways disorder 32.84 10.31 82 548081 20617 62920242
Proteinuria 32.64 10.31 73 548090 19072 62921787
Dysarthria 32.13 10.31 226 547937 42485 62898374
Forced expiratory volume decreased 31.92 10.31 3 548160 4965 62935894
Melaena 31.90 10.31 144 548019 30221 62910638
Tumour lysis syndrome 31.88 10.31 19 548144 8971 62931888
Ischaemic stroke 31.84 10.31 67 548096 17890 62922969
Atrial fibrillation 31.80 10.31 765 547398 115871 62824988
Malaise 31.74 10.31 3126 545037 412828 62528031
International normalised ratio increased 31.43 10.31 253 547910 46172 62894687
Angina pectoris 31.38 10.31 143 548020 29935 62910924
Hypomania 31.28 10.31 8 548155 6322 62934537
Jaundice 31.16 10.31 138 548025 29113 62911746
Acute hepatic failure 31.15 10.31 70 548093 18257 62922602
Muscle spasms 30.98 10.31 1070 547093 155080 62785779
Arrhythmia 30.59 10.31 198 547965 37942 62902917
Cytopenia 30.53 10.31 33 548130 11568 62929291
Haemophagocytic lymphohistiocytosis 30.52 10.31 28 548135 10599 62930260
Deep vein thrombosis 30.50 10.31 524 547639 83276 62857583
Aspartate aminotransferase increased 30.48 10.31 572 547591 89705 62851154
Colitis 30.37 10.31 270 547893 48258 62892601
Ventricular septal defect 30.35 10.31 95 548068 4283 62936576
Adverse event 30.29 10.31 781 547382 66778 62874081
Headache 30.26 10.31 4905 543258 628336 62312523
Drug level increased 30.23 10.31 98 548065 22638 62918221
Joint stiffness 30.22 10.31 519 547644 41350 62899509
Rash maculo-papular 30.18 10.31 157 548006 31739 62909120
Stevens-Johnson syndrome 30.17 10.31 112 548051 24838 62916021
Hyperlipidaemia 29.92 10.31 79 548084 19492 62921367
Device related infection 29.62 10.31 103 548060 23289 62917570
Metastases to lung 29.59 10.31 40 548123 12710 62928149
Laryngitis 29.59 10.31 249 547914 16718 62924141
Heart rate decreased 29.44 10.31 555 547608 45005 62895854
Abdominal pain 29.31 10.31 2159 546004 291297 62649562
Alanine aminotransferase increased 29.29 10.31 677 547486 103093 62837766
Aphasia 29.26 10.31 166 547997 32834 62908025
Erythema multiforme 28.96 10.31 27 548136 10142 62930717
Haematoma 28.84 10.31 179 547984 34641 62906218
Nodule 28.81 10.31 293 547870 20733 62920126
Urinary retention 28.75 10.31 149 548014 30152 62910707
Maternal exposure before pregnancy 28.71 10.31 136 548027 7467 62933392
Diabetes mellitus 28.50 10.31 326 547837 55484 62885375
Hepatotoxicity 28.35 10.31 195 547968 36846 62904013
Pleural effusion 28.34 10.31 601 547562 92609 62848250
Tenderness 28.29 10.31 309 547854 22269 62918590
Ventricular tachycardia 28.06 10.31 84 548079 19895 62920964
Rhinitis allergic 28.03 10.31 36 548127 11691 62929168
Respiratory depression 27.99 10.31 47 548116 13668 62927191
Acute myeloid leukaemia 27.93 10.31 67 548096 17080 62923779
Alcohol abuse 27.87 10.31 59 548104 2087 62938772
Panic attack 27.82 10.31 99 548064 22232 62918627
Cerebral infarction 27.77 10.31 109 548054 23784 62917075
Joint dislocation 27.72 10.31 266 547897 18534 62922325
Cough 27.62 10.31 2164 545999 290579 62650280
Dry skin 27.62 10.31 336 547827 56551 62884308
Enthesopathy 27.54 10.31 147 548016 8467 62932392
Graft versus host disease 27.41 10.31 12 548151 6751 62934108
Irritability 27.26 10.31 161 548002 31533 62909326
Sleep apnoea syndrome 27.23 10.31 144 548019 28989 62911870
Device use error 27.12 10.31 8 548155 5753 62935106
Status epilepticus 26.87 10.31 57 548106 15176 62925683
Withdrawal syndrome 26.72 10.31 86 548077 19911 62920948
Mania 26.54 10.31 41 548122 12326 62928533
Haemorrhage intracranial 26.46 10.31 47 548116 13372 62927487
Clostridium difficile colitis 26.43 10.31 90 548073 20479 62920380
Akathisia 26.39 10.31 24 548139 9122 62931737
Haemoptysis 26.29 10.31 143 548020 28583 62912276
Temperature regulation disorder 26.28 10.31 10 548153 6122 62934737
Blood pressure diastolic increased 26.22 10.31 162 548001 9848 62931011
Wheelchair user 26.06 10.31 116 548047 6203 62934656
Skin exfoliation 26.02 10.31 242 547921 42860 62897999
Injection site swelling 25.92 10.31 565 547598 47007 62893852
Coma 25.90 10.31 395 547768 63969 62876890
Abdominal distension 25.89 10.31 560 547603 86055 62854804
Ankylosing spondylitis 25.87 10.31 167 547996 10307 62930552
Myoclonus 25.85 10.31 62 548101 15806 62925053
Bradyphrenia 25.83 10.31 14 548149 6966 62933893
Drug dependence 25.78 10.31 116 548047 24367 62916492
Muscle rigidity 25.77 10.31 37 548126 11463 62929396
Bronchopulmonary aspergillosis 25.71 10.31 22 548141 8613 62932246
Coagulopathy 25.65 10.31 91 548072 20453 62920406
Small for dates baby 25.64 10.31 81 548082 3670 62937189
Unresponsive to stimuli 25.40 10.31 179 547984 33637 62907222
Acute graft versus host disease 25.20 10.31 4 548159 4424 62936435
Limb deformity 25.17 10.31 84 548079 3918 62936941
Purpura 25.15 10.31 37 548126 11348 62929511
Rash erythematous 25.09 10.31 240 547923 42270 62898589
Bone marrow failure 25.08 10.31 149 548014 29141 62911718
Latent tuberculosis 25.07 10.31 64 548099 2563 62938296
Lip swelling 25.05 10.31 161 548002 30902 62909957
Tardive dyskinesia 24.90 10.31 22 548141 8480 62932379
Swollen tongue 24.80 10.31 187 547976 34613 62906246
Muscle twitching 24.64 10.31 87 548076 19581 62921278
Hypothyroidism 24.61 10.31 242 547921 42390 62898469
Gastrointestinal disorder 24.60 10.31 1377 546786 129862 62810997
Complication of device removal 24.47 10.31 7 548156 5135 62935724
Infusion site pain 24.36 10.31 70 548093 16799 62924060
Pulmonary hypertension 24.36 10.31 204 547959 36919 62903940
Lupus-like syndrome 24.35 10.31 220 547943 15075 62925784
Fall 24.30 10.31 2991 545172 389343 62551516
Blood alcohol increased 24.17 10.31 29 548134 623 62940236
Paralysis 24.07 10.31 30 548133 9870 62930989
Nasal polyps 24.03 10.31 11 548152 6028 62934831
Musculoskeletal pain 24.01 10.31 1000 547163 91277 62849582
Premature rupture of membranes 23.97 10.31 96 548067 4897 62935962
Febrile bone marrow aplasia 23.91 10.31 17 548146 7308 62933551
Malignant mediastinal neoplasm 23.91 10.31 44 548119 1402 62939457
Localised infection 23.84 10.31 380 547783 29830 62911029
Breast cancer stage I 23.82 10.31 15 548148 6874 62933985
Suicidal ideation 23.80 10.31 387 547776 62034 62878825
Prescribed underdose 23.63 10.31 374 547789 29315 62911544
Tachypnoea 23.41 10.31 74 548089 17228 62923631
Pancreatitis 23.34 10.31 291 547872 48764 62892095
Acute respiratory failure 23.31 10.31 188 547975 34297 62906562
Facet joint syndrome 23.26 10.31 182 547981 11956 62928903
Mobility decreased 23.25 10.31 1274 546889 119885 62820974
Toxic epidermal necrolysis 23.24 10.31 126 548037 25208 62915651
Paradoxical drug reaction 23.08 10.31 4 548159 4148 62936711
Coronary artery disease 23.06 10.31 174 547989 32203 62908656
Hypothermia 22.98 10.31 52 548111 13529 62927330
Anuria 22.95 10.31 46 548117 12505 62928354
Multiple-drug resistance 22.89 10.31 8 548155 5162 62935697
Complication of device insertion 22.85 10.31 19 548144 7545 62933314
Peripheral venous disease 22.82 10.31 219 547944 15258 62925601
Pre-eclampsia 22.80 10.31 146 548017 8987 62931872
Cardiomyopathy 22.55 10.31 77 548086 17507 62923352
Sexual dysfunction 22.54 10.31 5 548158 4354 62936505
Tenosynovitis stenosans 22.41 10.31 72 548091 3292 62937567
Smear cervix abnormal 22.37 10.31 66 548097 2880 62937979
Pseudomonas infection 22.36 10.31 39 548124 11174 62929685
Abnormal behaviour 22.27 10.31 102 548061 21324 62919535
Tenosynovitis 22.26 10.31 199 547964 13596 62927263
Obesity 22.24 10.31 373 547790 29579 62911280
Infective pulmonary exacerbation of cystic fibrosis 22.20 10.31 26 548137 8791 62932068
Labelled drug-drug interaction medication error 22.11 10.31 52 548111 13347 62927512
Dermatitis atopic 22.07 10.31 31 548132 9693 62931166
Pathogen resistance 22.03 10.31 14 548149 6384 62934475
Chills 22.00 10.31 779 547384 112599 62828260
Lip dry 21.88 10.31 217 547946 15253 62925606
Developmental hip dysplasia 21.75 10.31 41 548122 1331 62939528
Memory impairment 21.71 10.31 710 547453 103548 62837311
Pulmonary oedema 21.65 10.31 338 547825 54535 62886324
Pemphigoid 21.51 10.31 19 548144 7325 62933534
Red blood cell sedimentation rate 21.47 10.31 91 548072 4763 62936096
Muscular weakness 21.44 10.31 851 547312 121502 62819357
Genital haemorrhage 21.44 10.31 19 548144 7313 62933546
Nightmare 21.40 10.31 89 548074 19105 62921754
Paraesthesia 21.38 10.31 1122 547041 155844 62785015
Immune reconstitution inflammatory syndrome 21.38 10.31 13 548150 6071 62934788
Retinitis 21.37 10.31 108 548055 6088 62934771
Product prescribing error 21.33 10.31 136 548027 26153 62914706
Aspergillus infection 21.32 10.31 23 548140 8070 62932789
Neck mass 21.24 10.31 74 548089 3529 62937330
General physical health deterioration 21.21 10.31 2017 546146 199385 62741474
Hyperprolactinaemia 21.15 10.31 4 548159 3896 62936963
Face oedema 21.14 10.31 96 548067 20116 62920743
Dysmorphism 20.95 10.31 55 548108 2241 62938618
Fear 20.93 10.31 68 548095 15698 62925161
Dislocation of vertebra 20.92 10.31 137 548026 8498 62932361
Acute myocardial infarction 20.87 10.31 177 547986 31947 62908912
Synovial cyst 20.87 10.31 158 548005 10275 62930584
Maternal exposure timing unspecified 20.69 10.31 118 548045 6969 62933890
Loss of consciousness 20.61 10.31 822 547341 117299 62823560
Sinus bradycardia 20.57 10.31 61 548102 14490 62926369
Erythema 20.54 10.31 1275 546888 174476 62766383
Postmortem blood drug level abnormal 20.44 10.31 20 548143 338 62940521
Depressed mood 20.43 10.31 235 547928 39956 62900903
Lymphopenia 20.42 10.31 85 548078 18242 62922617
Affective disorder 20.41 10.31 14 548149 6132 62934727
Rotator cuff repair 20.38 10.31 52 548111 2082 62938777
Skin papilloma 20.33 10.31 91 548072 4878 62935981
Placental disorder 20.29 10.31 42 548121 1462 62939397
Anhedonia 20.26 10.31 40 548123 10934 62929925
Hallucination, auditory 20.19 10.31 51 548112 12773 62928086
Mental disorder 20.06 10.31 136 548027 25783 62915076
Anti-cyclic citrullinated peptide antibody 20.04 10.31 113 548050 6645 62934214
Mucosal inflammation 19.92 10.31 285 547878 46643 62894216
Synovial fluid analysis 19.92 10.31 56 548107 2377 62938482
Lethargy 19.80 10.31 352 547811 55655 62885204
Accidental overdose 19.73 10.31 119 548044 23190 62917669
Hyperthyroidism 19.68 10.31 63 548100 14610 62926249
Product administration error 19.67 10.31 113 548050 22284 62918575
Ventricular fibrillation 19.62 10.31 46 548117 11821 62929038
Body height below normal 19.62 10.31 52 548111 2131 62938728
Lymphoedema 19.59 10.31 45 548118 11647 62929212
Therapy partial responder 19.54 10.31 39 548124 10619 62930240
Renal disorder 19.53 10.31 186 547977 32788 62908071
Prescribed overdose 19.37 10.31 408 547755 33745 62907114
Crying 19.33 10.31 120 548043 23223 62917636
Shock haemorrhagic 19.20 10.31 35 548128 9860 62930999
Hypervolaemia 19.16 10.31 155 548008 28258 62912601
Generalised oedema 19.13 10.31 71 548092 15747 62925112
Wound infection 19.09 10.31 275 547888 21135 62919724
Hypophagia 19.08 10.31 175 547988 31084 62909775
Vascular device infection 19.02 10.31 21 548142 7291 62933568
Adjustment disorder with depressed mood 19.01 10.31 152 548011 10052 62930807
Brain oedema 19.00 10.31 61 548102 14134 62926725
Exposure to toxic agent 19.00 10.31 97 548066 5490 62935369
Ketoacidosis 19.00 10.31 7 548156 4371 62936488
Hemiplegia 18.98 10.31 32 548131 9291 62931568
Epstein-Barr virus infection 18.94 10.31 25 548138 8025 62932834
Malignant melanoma 18.93 10.31 165 547998 11191 62929668
Subdural haematoma 18.88 10.31 62 548101 14266 62926593
Procedural pain 18.85 10.31 109 548054 21460 62919399
Complication associated with device 18.76 10.31 79 548084 16899 62923960
Hepatic cytolysis 18.73 10.31 69 548094 15338 62925521
Leukocytosis 18.65 10.31 139 548024 25796 62915063
Loose body in joint 18.64 10.31 37 548126 1249 62939610
Injection site bruising 18.64 10.31 484 547679 41426 62899433
Atrial septal defect 18.62 10.31 113 548050 6825 62934034
Feeling hot 18.60 10.31 314 547849 50040 62890819
Body temperature decreased 18.52 10.31 262 547901 20057 62920802
Dactylitis 18.41 10.31 57 548106 2555 62938304
Urinary incontinence 18.36 10.31 182 547981 31832 62909027
Eosinophil count increased 18.36 10.31 42 548121 10886 62929973
Graft versus host disease in gastrointestinal tract 18.28 10.31 3 548160 3238 62937621
Gastroenteritis viral 18.28 10.31 297 547866 23403 62917456
Tinnitus 18.23 10.31 208 547955 35420 62905439
Therapeutic response decreased 18.17 10.31 676 547487 60849 62880010
Presyncope 18.09 10.31 153 548010 27632 62913227
Acute respiratory distress syndrome 17.96 10.31 124 548039 23410 62917449
Foetal anticonvulsant syndrome 17.82 10.31 24 548139 581 62940278
Nervousness 17.82 10.31 176 547987 30803 62910056
Eating disorder 17.77 10.31 94 548069 18922 62921937
Injection site rash 17.74 10.31 244 547919 18565 62922294
Arthritis infective 17.70 10.31 106 548057 6372 62934487
Transplant dysfunction 17.70 10.31 10 548153 4862 62935997
Hallucination, visual 17.69 10.31 96 548067 19202 62921657
Syndactyly 17.69 10.31 21 548142 446 62940413
Skin ulcer 17.68 10.31 492 547671 42553 62898306
Synovial disorder 17.66 10.31 48 548115 1997 62938862
Joint noise 17.65 10.31 80 548083 4312 62936547
Femur fracture 17.64 10.31 479 547684 41277 62899582
Visual impairment 17.59 10.31 575 547588 83871 62856988
Hypophosphataemia 17.56 10.31 46 548117 11380 62929479
Acute chest syndrome 17.55 10.31 28 548135 793 62940066
Body temperature increased 17.55 10.31 221 547942 36971 62903888
Acute pulmonary oedema 17.55 10.31 27 548136 8131 62932728
Hepatitis B reactivation 17.48 10.31 3 548160 3134 62937725
Injection site pain 17.46 10.31 1324 546839 128476 62812383
Cardiac failure acute 17.33 10.31 35 548128 9488 62931371
Deep vein thrombosis postoperative 17.33 10.31 162 548001 11207 62929652
Multiple drug therapy 17.28 10.31 5 548158 3641 62937218
Sensitisation 17.28 10.31 4 548159 3382 62937477
Colitis microscopic 17.27 10.31 34 548129 9305 62931554
Dysuria 17.25 10.31 197 547966 33541 62907318
Ileus 17.22 10.31 67 548096 14658 62926201
Blood potassium decreased 17.22 10.31 257 547906 41769 62899090
Oedema peripheral 17.22 10.31 1405 546758 188106 62752753
Clear cell renal cell carcinoma 17.21 10.31 39 548124 1446 62939413
Right ventricular failure 17.18 10.31 83 548080 17105 62923754
Neutropenic colitis 17.16 10.31 3 548160 3092 62937767
Cardiotoxicity 17.14 10.31 29 548134 8409 62932450
Systemic inflammatory response syndrome 17.13 10.31 14 548149 5607 62935252
Hypocalcaemia 17.08 10.31 183 547980 31530 62909329
Hepatitis acute 17.05 10.31 33 548130 9087 62931772
Toxic encephalopathy 17.00 10.31 19 548144 6560 62934299
Haematemesis 16.99 10.31 174 547989 30238 62910621
Jaundice cholestatic 16.98 10.31 23 548140 7301 62933558
Acute coronary syndrome 16.95 10.31 39 548124 10087 62930772
Renal injury 16.92 10.31 35 548128 9404 62931455
Rheumatoid lung 16.91 10.31 72 548091 3776 62937083
Klebsiella infection 16.89 10.31 30 548133 8536 62932323
Glycosylated haemoglobin increased 16.79 10.31 53 548110 12345 62928514
Subarachnoid haemorrhage 16.70 10.31 65 548098 14218 62926641
Schizoaffective disorder 16.67 10.31 5 548158 3557 62937302
Peripheral sensory neuropathy 16.67 10.31 24 548139 7427 62933432
Multiple allergies 16.66 10.31 62 548101 13740 62927119
Laryngospasm 16.65 10.31 3 548160 3025 62937834
Sleep disorder due to a general medical condition 16.58 10.31 52 548111 12136 62928723
Chemical submission 16.56 10.31 16 548147 266 62940593
Exostosis 16.56 10.31 231 547932 17631 62923228
Hepatitis cholestatic 16.56 10.31 21 548142 6857 62934002
Cholecystitis chronic 16.47 10.31 41 548122 10320 62930539
Polyhydramnios 16.41 10.31 50 548113 2221 62938638
Bone lesion 16.30 10.31 16 548147 5865 62934994
Cardiac disorder 16.23 10.31 325 547838 50491 62890368
Dermatitis exfoliative 16.14 10.31 14 548149 5445 62935414
Cytomegalovirus viraemia 16.09 10.31 15 548148 5634 62935225
Hallucinations, mixed 16.04 10.31 11 548152 4818 62936041
Antinuclear antibody positive 15.92 10.31 121 548042 7878 62932981
Congenital arterial malformation 15.92 10.31 17 548146 320 62940539
Spinal stenosis 15.91 10.31 198 547965 14727 62926132
Salivary hypersecretion 15.90 10.31 26 548137 7640 62933219
Personality disorder 15.89 10.31 16 548147 5795 62935064
Dementia 15.88 10.31 96 548067 18698 62922161
Device breakage 15.87 10.31 49 548114 11493 62929366
Ulcer 15.83 10.31 315 547848 25792 62915067
Middle insomnia 15.78 10.31 56 548107 12587 62928272
Abdominal pain upper 15.77 10.31 1551 546612 204893 62735966
Myopathy 15.75 10.31 47 548116 11144 62929715
Bradykinesia 15.71 10.31 13 548150 5175 62935684
Breast cancer female 15.66 10.31 62 548101 13497 62927362
Device dislocation 15.65 10.31 144 548019 25561 62915298
Hyperuricaemia 15.60 10.31 14 548149 5356 62935503
Hypernatraemia 15.60 10.31 26 548137 7583 62933276
Human antichimeric antibody positive 15.58 10.31 41 548122 1673 62939186
Antibody test positive 15.44 10.31 55 548108 2652 62938207
Pallor 15.43 10.31 179 547984 30389 62910470
Product adhesion issue 15.34 10.31 11 548152 4708 62936151
Chronic sinusitis 15.30 10.31 58 548105 12785 62928074
Tumour marker increased 15.28 10.31 12 548151 4903 62935956
Plasma cell myeloma 15.26 10.31 218 547945 35687 62905172
Visual acuity reduced 15.21 10.31 118 548045 21708 62919151
Epistaxis 15.20 10.31 495 547668 72230 62868629
Pain in extremity 15.18 10.31 3161 545002 328325 62612534
Tubulointerstitial nephritis 15.12 10.31 105 548058 19798 62921061
Hypertransaminasaemia 15.07 10.31 21 548142 6588 62934271
Polyuria 15.03 10.31 32 548131 8510 62932349
Neonatal respiratory distress syndrome 15.01 10.31 56 548107 2762 62938097
Illness 15.00 10.31 316 547847 48743 62892116
Atrioventricular block 14.88 10.31 27 548136 7620 62933239
Carotid artery thrombosis 14.87 10.31 3 548160 2791 62938068
Head injury 14.79 10.31 158 548005 27238 62913621
Skin cancer 14.72 10.31 158 548005 11337 62929522
Nephropathy toxic 14.69 10.31 38 548125 9441 62931418
Amylase increased 14.63 10.31 20 548143 6325 62934534
Stillbirth 14.51 10.31 104 548059 6646 62934213
Scleritis 14.45 10.31 76 548087 4352 62936507
Product substitution issue 14.43 10.31 80 548083 15916 62924943
Paranoia 14.40 10.31 52 548111 11627 62929232
Septic shock 14.28 10.31 452 547711 66177 62874682
Product preparation error 14.25 10.31 19 548144 6073 62934786
Rebound effect 14.13 10.31 11 548152 4515 62936344
Rectal haemorrhage 14.07 10.31 319 547844 48711 62892148
Alcoholism 14.06 10.31 41 548122 1777 62939082
Skin toxicity 14.05 10.31 12 548151 4702 62936157
Bursitis 14.01 10.31 419 547744 36622 62904237
Metastases to lymph nodes 14.00 10.31 31 548132 8127 62932732
Glomerular filtration rate decreased 13.96 10.31 64 548099 13377 62927482
Colorectal cancer 13.95 10.31 7 548156 3638 62937221
Cardiogenic shock 13.92 10.31 94 548069 17838 62923021
Breast feeding 13.90 10.31 26 548137 839 62940020
Food allergy 13.90 10.31 51 548112 11350 62929509
Lupus vulgaris 13.86 10.31 94 548069 5900 62934959
Reversible cerebral vasoconstriction syndrome 13.85 10.31 3 548160 2655 62938204
Autism spectrum disorder 13.80 10.31 26 548137 844 62940015
Pulmonary tuberculosis 13.71 10.31 76 548087 4441 62936418
Bundle branch block left 13.67 10.31 25 548138 7034 62933825
Pericardial effusion 13.67 10.31 180 547983 29878 62910981
Intracranial pressure increased 13.61 10.31 15 548148 5212 62935647
Diabetes insipidus 13.60 10.31 3 548160 2622 62938237
Abortion incomplete 13.60 10.31 5 548158 3126 62937733
Hyperbilirubinaemia 13.54 10.31 51 548112 11263 62929596
Fear of injection 13.50 10.31 107 548056 7057 62933802
Sinus tachycardia 13.49 10.31 139 548024 24129 62916730
Adenovirus infection 13.45 10.31 7 548156 3564 62937295
Chronic graft versus host disease 13.39 10.31 5 548158 3097 62937762
Dermatitis acneiform 13.38 10.31 14 548149 4982 62935877
Hyperlactacidaemia 13.33 10.31 4 548159 2845 62938014
Product physical issue 13.29 10.31 14 548149 4966 62935893
Breast cancer metastatic 13.23 10.31 56 548107 11962 62928897
Hypoglycaemic coma 13.22 10.31 3 548160 2572 62938287
Incorrect product administration duration 13.21 10.31 53 548110 11493 62929366
Blood parathyroid hormone decreased 13.20 10.31 136 548027 9655 62931204
Crohn's disease 13.18 10.31 80 548083 4833 62936026
Respiration abnormal 13.09 10.31 22 548141 6395 62934464
Infusion site swelling 13.07 10.31 42 548121 9728 62931131
Cushingoid 12.98 10.31 121 548042 8364 62932495
Bacteraemia 12.95 10.31 92 548071 17256 62923603
Device issue 12.90 10.31 137 548026 23644 62917215
Circulatory collapse 12.88 10.31 124 548039 21814 62919045
Electrolyte imbalance 12.87 10.31 111 548052 19965 62920894
Delirium 12.82 10.31 335 547828 50206 62890653
Gastroschisis 12.80 10.31 17 548146 406 62940453
Fracture delayed union 12.80 10.31 48 548115 2374 62938485
Hereditary angioedema 12.76 10.31 29 548134 7533 62933326
Pregnancy with contraceptive device 12.75 10.31 13 548150 4681 62936178
Granuloma skin 12.75 10.31 120 548043 8317 62932542
Short stature 12.70 10.31 22 548141 668 62940191
Tendonitis 12.69 10.31 239 547924 19376 62921483
Injury 12.66 10.31 763 547400 72484 62868375
Haemorrhage in pregnancy 12.64 10.31 41 548122 1884 62938975
Acidosis 12.58 10.31 52 548111 11181 62929678
Wrong product administered 12.57 10.31 21 548142 6120 62934739
Postoperative wound infection 12.55 10.31 147 548016 10778 62930081
Cyanosis 12.54 10.31 90 548073 16845 62924014
Infusion site erythema 12.50 10.31 55 548108 11624 62929235
Blood glucose decreased 12.49 10.31 118 548045 20834 62920025
Blood phosphorus decreased 12.48 10.31 12 548151 4441 62936418
Atrial flutter 12.39 10.31 43 548120 9729 62931130
Atrial tachycardia 12.38 10.31 11 548152 4229 62936630
Chronic obstructive pulmonary disease 12.32 10.31 430 547733 62256 62878603
Bundle branch block right 12.30 10.31 15 548148 4983 62935876
Oliguria 12.26 10.31 39 548124 9062 62931797
Blood lactate dehydrogenase increased 12.20 10.31 134 548029 22982 62917877
Neutrophilia 12.20 10.31 12 548151 4394 62936465
Psychomotor hyperactivity 12.16 10.31 49 548114 10614 62930245
Sleep terror 12.12 10.31 4 548159 2676 62938183
Transaminases increased 12.11 10.31 194 547969 31173 62909686
Pneumonia viral 12.09 10.31 32 548131 7890 62932969
Impaired gastric emptying 12.09 10.31 47 548116 10285 62930574
Interstitial lung disease 12.09 10.31 425 547738 61483 62879376
Delusion 12.03 10.31 58 548105 11959 62928900
Lymph gland infection 12.02 10.31 18 548145 482 62940377
Polydipsia 12.00 10.31 8 548155 3556 62937303
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.98 10.31 5 548158 2894 62937965
Ejection fraction 11.97 10.31 3 548160 2403 62938456
Hot flush 11.97 10.31 343 547820 50816 62890043
Injection site warmth 11.94 10.31 191 547972 15004 62925855
Pruritus genital 11.93 10.31 4 548159 2650 62938209
Contrast media allergy 11.93 10.31 3 548160 2398 62938461
Exomphalos 11.91 10.31 19 548144 538 62940321
Congenital umbilical hernia 11.73 10.31 14 548149 299 62940560
Trigeminal neuralgia 11.71 10.31 8 548155 3511 62937348
Paraesthesia oral 11.67 10.31 108 548055 19148 62921711
Speech disorder developmental 11.64 10.31 21 548142 659 62940200
Congenital cerebral cyst 11.63 10.31 13 548150 258 62940601
Pneumonia 11.61 10.31 3646 544517 453121 62487738
Mood altered 11.59 10.31 77 548086 14666 62926193
Oligoarthritis 11.56 10.31 19 548144 552 62940307
Personality change 11.55 10.31 27 548136 6946 62933913
Victim of sexual abuse 11.55 10.31 21 548142 663 62940196
Learning disorder 11.53 10.31 21 548142 664 62940195
Uterine perforation 11.51 10.31 27 548136 6936 62933923
Nasal obstruction 11.49 10.31 37 548126 1694 62939165
Hypertelorism 11.47 10.31 17 548146 451 62940408
Product administered to patient of inappropriate age 11.46 10.31 7 548156 3261 62937598
Cleft lip and palate 11.37 10.31 20 548143 615 62940244
Ankle arthroplasty 11.36 10.31 38 548125 1775 62939084
Premature delivery 11.31 10.31 342 547821 29939 62910920
Epilepsy 11.26 10.31 165 547998 26900 62913959
Troponin increased 11.24 10.31 47 548116 10074 62930785
Toxicity to various agents 11.23 10.31 2357 545806 244893 62695966
Gestational hypertension 11.23 10.31 46 548117 2371 62938488
Talipes 11.22 10.31 34 548129 1506 62939353
Eye pruritus 11.19 10.31 105 548058 18566 62922293
Blood pressure inadequately controlled 11.17 10.31 16 548147 4962 62935897
Infusion site pruritus 11.14 10.31 22 548141 6013 62934846
Bronchial secretion retention 11.11 10.31 5 548158 2768 62938091
Onychomycosis 11.09 10.31 111 548052 7821 62933038
Ear infection 11.07 10.31 419 547744 37794 62903065
Terminal state 11.06 10.31 3 548160 2279 62938580
Induced labour 11.05 10.31 25 548138 926 62939933
Placenta praevia haemorrhage 11.04 10.31 9 548154 118 62940741
End stage renal disease 11.02 10.31 26 548137 6667 62934192
Skin plaque 10.97 10.31 36 548127 8284 62932575
Disturbance in social behaviour 10.91 10.31 11 548152 3982 62936877
Anger 10.86 10.31 63 548100 12393 62928466
Ingrown hair 10.85 10.31 19 548144 582 62940277
Nail injury 10.83 10.31 20 548143 639 62940220
Human anti-human antibody test 10.81 10.31 16 548147 424 62940435
Cyst rupture 10.79 10.31 20 548143 641 62940218
Heart rate increased 10.77 10.31 685 547478 93553 62847306
Inadequate analgesia 10.75 10.31 6 548157 2937 62937922
Drug effective for unapproved indication 10.73 10.31 8 548155 3356 62937503
Myocardial ischaemia 10.70 10.31 66 548097 12793 62928066
Full blood count abnormal 10.69 10.31 201 547962 31516 62909343
Lymphatic fistula 10.66 10.31 22 548141 764 62940095
Rales 10.65 10.31 65 548098 12632 62928227
Blindness 10.59 10.31 128 548035 21571 62919288
Drug tolerance 10.58 10.31 99 548064 6850 62934009
Blood urea increased 10.57 10.31 162 548001 26217 62914642
Hypercholesterolaemia 10.57 10.31 250 547913 21084 62919775
Embolism 10.56 10.31 34 548129 7872 62932987
Cystitis haemorrhagic 10.55 10.31 12 548151 4111 62936748
Threatened labour 10.54 10.31 23 548140 831 62940028
Blood loss anaemia 10.50 10.31 41 548122 8960 62931899
Hyperthermia 10.49 10.31 42 548121 9114 62931745
Cervical incompetence 10.49 10.31 19 548144 598 62940261
Affect lability 10.48 10.31 55 548108 11096 62929763
Panniculitis 10.46 10.31 147 548016 11238 62929621
Atrioventricular block second degree 10.45 10.31 11 548152 3903 62936956
Catatonia 10.44 10.31 14 548149 4463 62936396
Metastasis 10.43 10.31 18 548145 5179 62935680
Retrognathia 10.43 10.31 16 548147 438 62940421
Implant site pain 10.42 10.31 4 548159 2436 62938423
Laryngeal oedema 10.42 10.31 21 548142 5697 62935162
Eosinophilic granulomatosis with polyangiitis 10.40 10.31 3 548160 2189 62938670
Enterocolitis 10.36 10.31 34 548129 7824 62933035
Deafness 10.33 10.31 102 548061 17855 62923004
Kidney transplant rejection 10.32 10.31 13 548150 4258 62936601

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 1356.04 10.52 2228 202513 96868 34655322
Completed suicide 836.31 10.52 1803 202938 96365 34655825
Rheumatoid arthritis 482.13 10.52 830 203911 37408 34714782
Toxicity to various agents 473.59 10.52 2371 202370 197991 34554199
Foetal exposure during pregnancy 241.20 10.52 624 204117 37477 34714713
Alcohol interaction 206.34 10.52 156 204585 2757 34749433
Alcohol abuse 204.99 10.52 190 204551 4500 34747690
Psoriatic arthropathy 170.80 10.52 366 204375 19432 34732758
Cardio-respiratory arrest 167.78 10.52 705 204036 54568 34697622
Arthralgia 164.05 10.52 1618 203123 168423 34583767
Alcohol poisoning 135.14 10.52 134 204607 3459 34748731
Sickle cell anaemia with crisis 128.67 10.52 138 204603 3915 34748275
Dysmorphism 121.11 10.52 119 204622 3037 34749153
Suspected suicide 117.37 10.52 142 204599 4606 34747584
Acute kidney injury 112.18 10.52 1194 203547 303794 34448396
Product use in unapproved indication 103.18 10.52 348 204393 117151 34635039
Joint swelling 102.55 10.52 651 204090 59239 34692951
Febrile neutropenia 93.22 10.52 448 204293 136401 34615789
Psoriasis 89.58 10.52 457 204284 38355 34713835
Off label use 86.18 10.52 1839 202902 417685 34334505
Drug reaction with eosinophilia and systemic symptoms 82.80 10.52 45 204696 32967 34719223
Drug interaction 82.76 10.52 885 203856 225061 34527129
Premature baby 80.71 10.52 276 204465 19357 34732833
Exposure during pregnancy 78.00 10.52 166 204575 8768 34743422
Intentional overdose 77.40 10.52 479 204262 43195 34708995
Musculoskeletal stiffness 76.57 10.52 502 204239 46178 34706012
Disease progression 74.63 10.52 352 204389 107725 34644465
Enthesopathy 72.88 10.52 111 204630 4502 34747688
Hepatic function abnormal 70.33 10.52 94 204647 44269 34707921
Tenosynovitis 68.05 10.52 107 204634 4463 34747727
Blood pressure fluctuation 67.40 10.52 310 204431 24939 34727251
Synovitis 67.06 10.52 208 204533 13858 34738332
Speech disorder developmental 66.50 10.52 73 204668 2127 34750063
Drug resistance 62.64 10.52 37 204704 25890 34726300
Alcohol use 58.99 10.52 84 204657 3204 34748986
C-reactive protein abnormal 58.56 10.52 146 204595 8564 34743626
Exposure to toxic agent 57.45 10.52 88 204653 3587 34748603
Angioedema 57.42 10.52 81 204660 37293 34714897
Multiple organ dysfunction syndrome 56.66 10.52 243 204498 76323 34675867
Substance abuse 56.63 10.52 133 204608 7508 34744682
Cardiac failure 56.27 10.52 309 204432 90939 34661251
Foetal anticonvulsant syndrome 55.61 10.52 50 204691 1137 34751053
Intentional product misuse 55.60 10.52 457 204284 45154 34707036
Cytomegalovirus infection 54.25 10.52 44 204697 26091 34726099
Neonatal respiratory distress syndrome 54.01 10.52 90 204651 3944 34748246
Renal failure 53.71 10.52 497 204244 130060 34622130
Arthropathy 52.72 10.52 303 204438 26604 34725586
Atrial septal defect 51.91 10.52 126 204615 7266 34744924
Maternal exposure during pregnancy 50.81 10.52 98 204643 4820 34747370
Alanine aminotransferase abnormal 49.15 10.52 94 204647 4594 34747596
Hypospadias 49.13 10.52 76 204665 3125 34749065
Blood alcohol increased 47.36 10.52 39 204702 784 34751406
Pyrexia 46.76 10.52 1541 203200 331472 34420718
Autism spectrum disorder 46.21 10.52 62 204679 2234 34749956
Renal impairment 46.02 10.52 344 204397 94169 34658021
Maternal drugs affecting foetus 45.95 10.52 83 204658 3882 34748308
Toxic epidermal necrolysis 45.48 10.52 36 204705 21610 34730580
Learning disorder 45.37 10.52 43 204698 1048 34751142
Palmar-plantar erythrodysaesthesia syndrome 44.95 10.52 21 204720 16774 34735416
Cryptorchism 43.99 10.52 57 204684 1984 34750206
Low birth weight baby 43.49 10.52 123 204618 7782 34744408
Asphyxia 43.27 10.52 112 204629 6723 34745467
Bradycardia 42.95 10.52 262 204479 75156 34677034
Blood pressure systolic increased 42.72 10.52 255 204486 22697 34729493
Hypoglycaemia neonatal 42.40 10.52 54 204687 1847 34750343
Arthritis 41.43 10.52 320 204421 31026 34721164
Tongue disorder 39.64 10.52 93 204648 5246 34746944
Syndactyly 39.20 10.52 36 204705 842 34751348
Small for dates baby 39.05 10.52 77 204664 3850 34748340
Rheumatoid nodule 38.45 10.52 65 204676 2882 34749308
Ventricular septal defect 38.04 10.52 77 204664 3924 34748266
Maternal exposure during breast feeding 37.94 10.52 46 204695 1495 34750695
Blood pressure systolic abnormal 37.56 10.52 76 204665 3872 34748318
Immune reconstitution inflammatory syndrome 37.10 10.52 4 204737 8755 34743435
Substance use disorder 36.86 10.52 33 204708 746 34751444
Suicide attempt 36.51 10.52 370 204371 38746 34713444
Pain 36.38 10.52 1505 203236 203170 34549020
Nasopharyngitis 36.01 10.52 593 204148 69375 34682815
Rash maculo-papular 35.95 10.52 70 204671 28381 34723809
Malignant neoplasm progression 35.83 10.52 336 204405 87710 34664480
Drug ineffective 35.66 10.52 2253 202488 454498 34297692
Developmental delay 34.62 10.52 60 204681 2715 34749475
Overdose 34.17 10.52 735 204006 90324 34661866
Pathogen resistance 34.04 10.52 7 204734 9475 34742715
Hand deformity 33.43 10.52 70 204671 3655 34748535
Talipes 32.85 10.52 48 204693 1875 34750315
Alcohol withdrawal syndrome 32.81 10.52 42 204699 1444 34750746
Blood pressure diastolic abnormal 32.64 10.52 81 204660 4737 34747453
Joint effusion 31.76 10.52 84 204657 5109 34747081
Drug dependence 31.32 10.52 246 204495 23971 34728219
Joint laxity 31.27 10.52 23 204718 389 34751801
Rhabdomyolysis 30.88 10.52 253 204488 67910 34684280
Osteoarthritis 30.85 10.52 217 204524 20425 34731765
Neurotoxicity 30.79 10.52 36 204705 17974 34734216
Foot deformity 30.44 10.52 76 204665 4461 34747729
Exposure via breast milk 29.84 10.52 47 204694 1963 34750227
Respiratory failure 29.69 10.52 452 204289 108120 34644070
Behaviour disorder 29.60 10.52 79 204662 4831 34747359
Drug ineffective for unapproved indication 29.40 10.52 59 204682 23656 34728534
Intentional product use issue 29.33 10.52 503 204238 59313 34692877
Anaphylactic shock 29.32 10.52 30 204711 15911 34736279
Hyperglycaemia 28.76 10.52 126 204615 39354 34712836
Neuroleptic malignant syndrome 28.41 10.52 38 204703 17896 34734294
Blood pressure diastolic decreased 28.34 10.52 117 204624 8977 34743213
Sedation 28.02 10.52 50 204691 20956 34731234
Grip strength decreased 27.80 10.52 59 204682 3110 34749080
Congenital hand malformation 27.75 10.52 25 204716 570 34751620
Neutropenia 27.58 10.52 703 204038 156075 34596115
Plagiocephaly 27.50 10.52 24 204717 524 34751666
Peripheral swelling 27.49 10.52 614 204127 75927 34676263
Alcoholism 26.94 10.52 56 204685 2909 34749281
Hypermobility syndrome 26.86 10.52 20 204721 345 34751845
Heart rate decreased 26.67 10.52 294 204447 31451 34720739
Delirium 26.54 10.52 150 204591 43841 34708349
Tendonitis 26.48 10.52 115 204626 9025 34743165
Wound 26.30 10.52 163 204578 14701 34737489
Knee arthroplasty 25.80 10.52 99 204642 7345 34744845
Hepatic fibrosis 25.65 10.52 72 204669 4535 34747655
Basal cell carcinoma 25.59 10.52 200 204541 19458 34732732
Serotonin syndrome 25.22 10.52 49 204692 19884 34732306
Blood pressure increased 25.14 10.52 685 204056 87417 34664773
Hypoglycaemia 25.11 10.52 202 204539 54438 34697752
Jaundice neonatal 25.06 10.52 35 204706 1311 34750879
Pulmonary fibrosis 24.98 10.52 189 204552 18207 34733983
Constipation 24.96 10.52 611 204130 136371 34615819
Agranulocytosis 24.88 10.52 65 204676 23756 34728434
Caesarean section 24.70 10.52 45 204696 2119 34750071
Venoocclusive liver disease 24.55 10.52 8 204733 7958 34744232
Acute chest syndrome 24.24 10.52 27 204714 800 34751390
Astigmatism 24.21 10.52 31 204710 1066 34751124
Dysgraphia 24.15 10.52 46 204695 2241 34749949
Lactic acidosis 24.12 10.52 113 204628 34659 34717531
Red blood cell sedimentation rate increased 24.08 10.52 112 204629 9050 34743140
Intellectual disability 23.74 10.52 34 204707 1304 34750886
Large for dates baby 23.58 10.52 28 204713 890 34751300
Diaphragmatic disorder 23.51 10.52 33 204708 1242 34750948
Cerebral haemorrhage 23.38 10.52 115 204626 34822 34717368
Language disorder 23.36 10.52 45 204696 2211 34749979
Finger deformity 23.33 10.52 36 204705 1477 34750713
Urticaria 23.29 10.52 243 204498 62134 34690056
Hydrops foetalis 23.19 10.52 27 204714 840 34751350
Osteonecrosis of jaw 22.61 10.52 44 204697 17845 34734345
Aspergillus infection 22.60 10.52 23 204718 12231 34739959
Lower respiratory tract infection 22.59 10.52 284 204457 31353 34720837
Foetal growth restriction 22.59 10.52 64 204677 4053 34748137
Stevens-Johnson syndrome 22.57 10.52 47 204694 18592 34733598
Polyarthritis 22.44 10.52 68 204673 4472 34747718
Proteinuria 21.75 10.52 48 204693 18594 34733596
Ultrasound antenatal screen 21.40 10.52 21 204720 535 34751655
Appendicolith 21.16 10.52 12 204729 8589 34743601
Hypotonia neonatal 20.73 10.52 32 204709 1313 34750877
Sleep disorder due to a general medical condition 20.62 10.52 3 204738 5218 34746972
Anal fistula 20.54 10.52 74 204667 5325 34746865
Ventricular tachycardia 20.49 10.52 83 204658 26496 34725694
Wrong technique in product usage process 20.48 10.52 125 204616 35861 34716329
Hyperbilirubinaemia neonatal 20.33 10.52 24 204717 758 34751432
C-reactive protein increased 20.06 10.52 436 204305 53662 34698528
Cardiogenic shock 19.97 10.52 84 204657 26534 34725656
Ex-drug abuser 19.96 10.52 12 204729 142 34752048
Musculoskeletal pain 19.95 10.52 280 204461 31683 34720507
Respiratory depression 19.91 10.52 163 204578 16082 34736108
Motor developmental delay 19.91 10.52 22 204719 646 34751544
Knee deformity 19.91 10.52 22 204719 646 34751544
Blood creatinine increased 19.73 10.52 415 204326 94561 34657629
Dyspraxia 19.67 10.52 18 204723 419 34751771
Hydrocele 19.65 10.52 40 204701 2047 34750143
Cholestasis 19.63 10.52 86 204655 26862 34725328
Drug withdrawal syndrome neonatal 19.61 10.52 56 204685 3563 34748627
Interstitial lung disease 19.51 10.52 267 204474 65015 34687175
Infusion related reaction 19.48 10.52 427 204314 52630 34699560
Attention deficit hyperactivity disorder 19.46 10.52 45 204696 2514 34749676
Second primary malignancy 19.41 10.52 11 204730 7875 34744315
Blood pressure diastolic increased 19.23 10.52 69 204672 4956 34747234
Radiation inflammation 19.08 10.52 25 204716 880 34751310
Pain in extremity 19.07 10.52 915 203826 125598 34626592
Selective eating disorder 19.07 10.52 36 204705 1742 34750448
Melaena 19.05 10.52 125 204616 35255 34716935
Ankylosing spondylitis 18.99 10.52 74 204667 5530 34746660
Drug intolerance 18.97 10.52 470 204271 59100 34693090
Trisomy 18 18.96 10.52 23 204718 748 34751442
Body temperature decreased 18.88 10.52 136 204605 12898 34739292
Road traffic accident 18.72 10.52 170 204571 17280 34734910
Arthritis infective 18.61 10.52 53 204688 3366 34748824
Altered state of consciousness 18.60 10.52 70 204671 22823 34729367
Poisoning deliberate 18.53 10.52 93 204648 7751 34744439
Thrombocytopenia 18.45 10.52 738 204003 155509 34596681
Tuberculosis 18.40 10.52 99 204642 8478 34743712
Nasal disorder 18.21 10.52 37 204704 1891 34750299
Otitis media 18.12 10.52 47 204694 2825 34749365
Ear disorder 17.86 10.52 34 204707 1656 34750534
Vomiting 17.77 10.52 1230 203511 246391 34505799
Colitis ulcerative 17.75 10.52 161 204580 16359 34735831
Foetal disorder 17.70 10.52 23 204718 803 34751387
Asthma 17.67 10.52 162 204579 42494 34709696
Skin cancer 17.65 10.52 112 204629 10185 34742005
Acute graft versus host disease 17.61 10.52 8 204733 6495 34745695
Congenital foot malformation 17.58 10.52 17 204724 425 34751765
Vitamin D deficiency 17.53 10.52 81 204660 6527 34745663
Dyslexia 17.51 10.52 15 204726 319 34751871
Respiratory disorder neonatal 17.48 10.52 33 204708 1597 34750593
Alcohol intolerance 17.45 10.52 17 204724 429 34751761
Cleft lip and palate 17.40 10.52 24 204717 888 34751302
Limb reduction defect 17.19 10.52 14 204727 277 34751913
Cystitis haemorrhagic 16.99 10.52 6 204735 5673 34746517
Bronchopulmonary aspergillosis 16.89 10.52 38 204703 14621 34737569
Haemoglobin decreased 16.86 10.52 867 203874 119905 34632285
Agitation neonatal 16.79 10.52 26 204715 1070 34751120
Hepatocellular injury 16.72 10.52 70 204671 22141 34730049
Joint stiffness 16.66 10.52 115 204626 10758 34741432
Hyperkalaemia 16.61 10.52 296 204445 69093 34683097
Red blood cell sedimentation rate 16.57 10.52 27 204714 1161 34751029
Inflammation 16.52 10.52 245 204496 28050 34724140
Post procedural infection 16.35 10.52 64 204677 4792 34747398
Hypocalcaemia 16.22 10.52 80 204661 24209 34727981
No adverse event 16.20 10.52 74 204667 22853 34729337
Hepatic failure 16.17 10.52 127 204614 34404 34717786
Arthritis bacterial 16.16 10.52 66 204675 5040 34747150
Strabismus 16.09 10.52 33 204708 1698 34750492
Pruritus 16.03 10.52 674 204067 141307 34610883
Product quality issue 15.94 10.52 49 204692 16986 34735204
Medical device implantation 15.93 10.52 19 204722 607 34751583
Blood parathyroid hormone decreased 15.92 10.52 30 204711 1450 34750740
Multiple congenital abnormalities 15.82 10.52 18 204723 546 34751644
Crohn's disease 15.70 10.52 47 204694 3070 34749120
BK virus infection 15.63 10.52 7 204734 5731 34746459
Ear infection 15.55 10.52 108 204633 10123 34742067
Eosinophilia 15.49 10.52 90 204651 26132 34726058
Septic shock 15.47 10.52 312 204429 71522 34680668
Lacrimal disorder 15.44 10.52 14 204727 322 34751868
Congenital bladder anomaly 15.43 10.52 13 204728 270 34751920
Hypertriglyceridaemia 15.42 10.52 16 204725 8432 34743758
Joint range of motion decreased 15.42 10.52 84 204657 7228 34744962
Cleft lip 15.40 10.52 14 204727 323 34751867
Hepatic steatosis 15.40 10.52 170 204571 18192 34733998
Thrombotic microangiopathy 15.39 10.52 24 204717 10606 34741584
Decreased appetite 15.38 10.52 807 203934 165585 34586605
Hypertelorism 15.36 10.52 18 204723 564 34751626
Weight decrease neonatal 15.33 10.52 14 204727 325 34751865
Serum ferritin increased 15.33 10.52 74 204667 6072 34746118
Transplant rejection 15.19 10.52 23 204718 10288 34741902
Progressive multifocal leukoencephalopathy 15.15 10.52 21 204720 9743 34742447
Pancytopenia 15.14 10.52 692 204049 94465 34657725
Juvenile idiopathic arthritis 15.14 10.52 34 204707 1863 34750327
Back disorder 15.12 10.52 78 204663 6573 34745617
Granuloma skin 15.11 10.52 27 204714 1252 34750938
Ventricular fibrillation 15.10 10.52 76 204665 22878 34729312
Pectus excavatum 15.05 10.52 12 204729 230 34751960
Adenovirus infection 14.98 10.52 6 204735 5251 34746939
Psychotic disorder 14.95 10.52 83 204658 24369 34727821
Ankyloglossia congenital 14.89 10.52 13 204728 284 34751906
End stage renal disease 14.84 10.52 18 204723 8843 34743347
Polydactyly 14.84 10.52 26 204715 1187 34751003
Anal fissure 14.82 10.52 57 204684 4233 34747957
Diabetic ketoacidosis 14.73 10.52 55 204686 17977 34734213
Congenital anomaly 14.69 10.52 28 204713 1365 34750825
Dyspnoea 14.62 10.52 1959 202782 374823 34377367
Therapy partial responder 14.61 10.52 21 204720 9595 34742595
Acute generalised exanthematous pustulosis 14.57 10.52 11 204730 6765 34745425
Dextrocardia 14.52 10.52 9 204732 113 34752077
Umbilical hernia 14.44 10.52 60 204681 4617 34747573
Synovial cyst 14.42 10.52 38 204703 2306 34749884
Renal aplasia 14.38 10.52 20 204721 746 34751444
Prescription drug used without a prescription 14.37 10.52 36 204705 2118 34750072
Spinal disorder 14.29 10.52 56 204685 4196 34747994
Chronic graft versus host disease 14.19 10.52 4 204737 4369 34747821
Poor venous access 14.10 10.52 64 204677 5119 34747071
Haematocrit decreased 14.05 10.52 266 204475 31950 34720240
Hypokalaemia 14.03 10.52 248 204493 57966 34694224
Pulmonary alveolar haemorrhage 13.97 10.52 14 204727 7498 34744692
Disseminated intravascular coagulation 13.92 10.52 73 204668 21743 34730447
Posterior reversible encephalopathy syndrome 13.91 10.52 23 204718 9931 34742259
Congenital diaphragmatic hernia 13.86 10.52 12 204729 259 34751931
Cerebral infarction 13.79 10.52 99 204642 27356 34724834
Neoplasm progression 13.75 10.52 80 204661 23220 34728970
Opiates positive 13.75 10.52 17 204724 564 34751626
Ascites 13.72 10.52 191 204550 46380 34705810
Myelosuppression 13.72 10.52 62 204679 19203 34732987
Cytomegalovirus viraemia 13.64 10.52 14 204727 7416 34744774
Haemangioma congenital 13.64 10.52 16 204725 502 34751688
Tubulointerstitial nephritis 13.61 10.52 70 204671 20954 34731236
Emphysema 13.58 10.52 99 204642 9426 34742764
Weight decreased 13.57 10.52 1204 203537 175097 34577093
Microcephaly 13.50 10.52 20 204721 791 34751399
Joint ankylosis 13.48 10.52 29 204712 1543 34750647
Haemorrhage intracranial 13.45 10.52 48 204693 15898 34736292
Arthrodesis 13.40 10.52 15 204726 447 34751743
Abortion spontaneous 13.37 10.52 14 204727 386 34751804
Tumour lysis syndrome 13.32 10.52 53 204688 17006 34735184
Oesophageal fibrosis 13.26 10.52 10 204731 176 34752014
Malignant melanoma 13.25 10.52 87 204654 8003 34744187
Nausea 13.21 10.52 1767 202974 338141 34414049
Acute graft versus host disease in skin 13.17 10.52 7 204734 5194 34746996
Oropharyngeal pain 13.16 10.52 286 204455 35199 34716991
Nephrotic syndrome 13.14 10.52 14 204727 7289 34744901
Foetal alcohol syndrome 13.10 10.52 9 204732 136 34752054
Hernia pain 13.06 10.52 12 204729 281 34751909
Tooth malformation 13.02 10.52 10 204731 181 34752009
Myalgia 13.00 10.52 384 204357 83726 34668464
Arnold-Chiari malformation 12.94 10.52 13 204728 341 34751849
Vascular insufficiency 12.94 10.52 13 204728 341 34751849
Aggression 12.88 10.52 309 204432 38655 34713535
C-reactive protein decreased 12.87 10.52 33 204708 1969 34750221
Immunodeficiency 12.86 10.52 65 204676 5433 34746757
Hepatitis E virus test positive 12.85 10.52 12 204729 287 34751903
Patent ductus arteriosus 12.79 10.52 46 204695 3308 34748882
Cytokine release syndrome 12.74 10.52 80 204661 22797 34729393
Latent tuberculosis 12.68 10.52 26 204715 1337 34750853
Glycosylated haemoglobin increased 12.64 10.52 30 204711 11330 34740860
Developmental coordination disorder 12.57 10.52 10 204731 191 34751999
Therapeutic product effect decreased 12.56 10.52 279 204462 34464 34717726
Anti-cyclic citrullinated peptide antibody positive 12.50 10.52 31 204710 1812 34750378
Gastrointestinal infection 12.49 10.52 67 204674 5731 34746459
Spina bifida 12.49 10.52 13 204728 356 34751834
COVID-19 pneumonia 12.44 10.52 54 204687 16913 34735277
Skin injury 12.43 10.52 36 204705 2309 34749881
Fistula discharge 12.43 10.52 20 204721 851 34751339
Autoscopy 12.38 10.52 11 204730 246 34751944
Glomerular filtration rate decreased 12.33 10.52 37 204704 12924 34739266
Gun shot wound 12.30 10.52 23 204718 1105 34751085
Appendicitis 12.21 10.52 45 204696 14762 34737428
Nodule 12.20 10.52 75 204666 6744 34745446
Oesophageal adenocarcinoma 12.19 10.52 20 204721 865 34751325
Hypertransaminasaemia 12.19 10.52 9 204732 5597 34746593
Localised infection 12.18 10.52 157 204584 17430 34734760
Cytomegalovirus chorioretinitis 12.18 10.52 3 204738 3586 34748604
Chronic kidney disease 12.14 10.52 169 204572 41041 34711149
Dermatitis acneiform 12.13 10.52 11 204730 6178 34746012
Scoliosis 12.13 10.52 40 204701 2753 34749437
Maternal exposure timing unspecified 12.09 10.52 13 204728 370 34751820
Septic arthritis staphylococcal 12.05 10.52 15 204726 501 34751689
Bradycardia neonatal 12.04 10.52 21 204720 955 34751235
Hepatitis E antibody positive 12.02 10.52 11 204730 256 34751934
Bone cyst 12.02 10.52 28 204713 1572 34750618
Obsessive-compulsive disorder 12.01 10.52 9 204732 5555 34746635
Foetal heart rate deceleration abnormality 11.94 10.52 15 204726 506 34751684
Nephropathy toxic 11.92 10.52 36 204705 12552 34739638
Neck mass 11.87 10.52 28 204713 1585 34750605
Product prescribing error 11.85 10.52 82 204659 22845 34729345
Endophthalmitis 11.78 10.52 3 204738 3505 34748685
Hyperthermia 11.72 10.52 28 204713 10549 34741641
Blood ethanol 11.69 10.52 8 204733 120 34752070
Nerve compression 11.68 10.52 44 204697 3235 34748955
Gastroschisis 11.67 10.52 9 204732 164 34752026
Haemophagocytic lymphohistiocytosis 11.66 10.52 38 204703 12935 34739255
Hepatitis 11.62 10.52 87 204654 23817 34728373
Alcoholic liver disease 11.60 10.52 16 204725 592 34751598
Neutrophil count decreased 11.60 10.52 220 204521 50884 34701306
Drug use disorder 11.58 10.52 52 204689 4139 34748051
Low set ears 11.55 10.52 14 204727 455 34751735
Sepsis 11.49 10.52 830 203911 165731 34586459
Haemolysis 11.46 10.52 84 204657 8010 34744180
Foetal distress syndrome 11.46 10.52 22 204719 1078 34751112
Respiratory rate increased 11.44 10.52 98 204643 9796 34742394
Device leakage 11.39 10.52 13 204728 6562 34745628
Haematotoxicity 11.39 10.52 19 204722 8175 34744015
Lymphopenia 11.37 10.52 53 204688 16282 34735908
Concomitant disease aggravated 11.34 10.52 10 204731 5691 34746499
Hepatitis B 11.30 10.52 11 204730 5972 34746218
Hyponatraemia 11.22 10.52 384 204357 82307 34669883
Prostatic specific antigen increased 11.21 10.52 46 204695 14634 34737556
Cardiac failure chronic 11.20 10.52 18 204723 7861 34744329
Infective pulmonary exacerbation of cystic fibrosis 11.20 10.52 14 204727 6787 34745403
Lipase increased 11.18 10.52 24 204717 9392 34742798
Hypothyroidism 11.18 10.52 74 204667 20828 34731362
Erythema multiforme 11.17 10.52 21 204720 8628 34743562
Lymphocyte count decreased 11.16 10.52 82 204659 22540 34729650
Cardiotoxicity 11.12 10.52 10 204731 5638 34746552
Lung neoplasm malignant 11.10 10.52 153 204588 17242 34734948
Akathisia 11.09 10.52 19 204722 8090 34744100
Maternal exposure before pregnancy 11.06 10.52 18 204723 773 34751417
Educational problem 11.04 10.52 15 204726 547 34751643
Disease recurrence 11.03 10.52 77 204664 21413 34730777
Anal atresia 11.00 10.52 11 204730 287 34751903
Paradoxical drug reaction 10.99 10.52 3 204738 3348 34748842
Blood insulin increased 10.98 10.52 12 204729 348 34751842
Panniculitis 10.94 10.52 31 204710 1963 34750227
Facial pain 10.93 10.52 4 204737 3700 34748490
Haemangioma 10.91 10.52 30 204711 1867 34750323
Hepatic enzyme increased 10.89 10.52 303 204438 38777 34713413
Cleft palate 10.87 10.52 16 204725 629 34751561
Fistula 10.87 10.52 73 204668 6767 34745423
Drug eruption 10.86 10.52 70 204671 19828 34732362
Pulmonary artery stenosis congenital 10.81 10.52 14 204727 487 34751703
Bronchiolitis 10.81 10.52 42 204699 3134 34749056
Impaired driving ability 10.80 10.52 37 204704 2596 34749594
Kidney infection 10.73 10.52 61 204680 5333 34746857
Lip swelling 10.71 10.52 53 204688 16027 34736163
Renal tubular disorder 10.70 10.52 7 204734 4636 34747554
Psychomotor retardation 10.63 10.52 46 204695 3604 34748586
Ischaemic stroke 10.59 10.52 63 204678 18187 34734003
Visceral oedema 10.58 10.52 7 204734 99 34752091
Sensorimotor disorder 10.57 10.52 13 204728 429 34751761
Diverticular perforation 10.56 10.52 44 204697 3390 34748800
Complications of transplanted kidney 10.55 10.52 7 204734 4602 34747588
Ear malformation 10.54 10.52 11 204730 302 34751888
Hypermetropia 10.53 10.52 14 204727 500 34751690

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1098.48 10.02 3662 573334 204808 78962584
Completed suicide 1069.54 10.02 4054 572942 241713 78925679
Drug abuse 985.63 10.02 2999 573997 159692 79007700
Pemphigus 862.14 10.02 2094 574902 97488 79069904
Arthropathy 859.84 10.02 3028 573968 174083 78993309
Systemic lupus erythematosus 854.81 10.02 2359 574637 118790 79048602
Hand deformity 835.19 10.02 2124 574872 101795 79065597
Joint swelling 798.75 10.02 4160 572836 284486 78882906
Synovitis 795.40 10.02 2650 574346 148084 79019308
Glossodynia 745.67 10.02 2029 574967 101308 79066084
Anti-cyclic citrullinated peptide antibody positive 640.73 10.02 1673 575323 81470 79085922
Wound 626.54 10.02 2058 574938 114121 79053271
Arthralgia 594.19 10.02 6534 570462 565269 78602123
Maternal exposure during pregnancy 592.06 10.02 2251 574745 134287 79033105
Pericarditis 567.91 10.02 1853 575143 102383 79065009
Infusion related reaction 552.94 10.02 3194 573802 227043 78940349
Abdominal discomfort 491.68 10.02 3302 573694 247425 78919967
Discomfort 461.44 10.02 1967 575029 123650 79043742
Swelling 443.54 10.02 2885 574111 213826 78953566
Therapeutic product effect decreased 435.64 10.02 2337 574659 161526 79005866
Alopecia 427.49 10.02 3003 573993 228352 78939040
Pain 419.77 10.02 7284 569712 696518 78470874
Duodenal ulcer perforation 400.88 10.02 1221 575775 64990 79102402
Contraindicated product administered 398.71 10.02 2217 574779 155321 79012071
Helicobacter infection 397.58 10.02 1259 575737 68445 79098947
Febrile neutropenia 393.48 10.02 666 576330 230333 78937059
Rheumatoid factor positive 382.62 10.02 1125 575871 58714 79108678
Acute kidney injury 378.49 10.02 2207 574789 517197 78650195
Musculoskeletal stiffness 372.86 10.02 2354 574642 172654 78994738
Drug interaction 365.80 10.02 1652 575344 413531 78753861
Psoriatic arthropathy 342.92 10.02 1292 575704 76707 79090685
Hepatic enzyme increased 334.07 10.02 2365 574631 180245 78987147
Nasopharyngitis 324.56 10.02 3030 573966 250851 78916541
Drug intolerance 318.25 10.02 3113 573883 261006 78906386
Toxicity to various agents 309.48 10.02 4519 572477 417021 78750371
Exposure during pregnancy 290.47 10.02 1474 575522 99658 79067734
Alcohol interaction 271.03 10.02 248 576748 4626 79162766
Impaired healing 254.82 10.02 1282 575714 86373 79081019
Drug reaction with eosinophilia and systemic symptoms 219.12 10.02 95 576901 64149 79103243
C-reactive protein abnormal 219.07 10.02 809 576187 47558 79119834
Muscle injury 218.90 10.02 811 576185 47750 79119642
Folliculitis 213.98 10.02 881 576115 54499 79112893
Irritable bowel syndrome 208.19 10.02 948 576048 61293 79106099
Disease progression 207.13 10.02 664 576332 183698 78983694
Peripheral swelling 200.94 10.02 2899 574097 266718 78900674
Malignant neoplasm progression 200.77 10.02 427 576569 135563 79031829
Sickle cell anaemia with crisis 198.09 10.02 265 576731 7657 79159735
Neutropenia 197.85 10.02 1244 575752 286466 78880926
Hypersensitivity 197.14 10.02 2824 574172 259415 78907977
Sinusitis 196.10 10.02 2221 574775 193280 78974112
Red blood cell sedimentation rate abnormal 195.49 10.02 454 576542 20509 79146883
Lower respiratory tract infection 194.40 10.02 1599 575397 127621 79039771
Bradycardia 194.04 10.02 433 576563 135124 79032268
Sleep disorder due to general medical condition, insomnia type 191.81 10.02 722 576274 42834 79124558
Renal failure 190.56 10.02 777 576219 200191 78967201
Treatment failure 188.60 10.02 1975 575021 168511 78998881
Product use issue 187.25 10.02 2331 574665 207491 78959901
Cardio-respiratory arrest 185.44 10.02 1383 575613 107127 79060265
Knee arthroplasty 183.95 10.02 709 576287 42539 79124853
Blister 183.26 10.02 1485 575511 117991 79049401
Cardiac failure 178.62 10.02 551 576445 154291 79013101
Arthritis 174.11 10.02 1424 575572 113456 79053936
Hip arthroplasty 166.92 10.02 604 576392 35152 79132240
Blood pressure fluctuation 165.11 10.02 938 576058 66207 79101185
Hepatic function abnormal 164.98 10.02 171 576825 72936 79094456
Hyponatraemia 158.50 10.02 704 576292 177144 78990248
Osteoarthritis 158.47 10.02 1129 575867 86180 79081212
Constipation 156.74 10.02 1302 575694 281748 78885644
Renal impairment 151.46 10.02 607 576389 157176 79010216
Sedation 151.37 10.02 94 576902 51801 79115591
Drug resistance 147.84 10.02 60 576936 42153 79125239
Alcohol abuse 145.90 10.02 187 576809 5176 79162216
Rheumatic fever 144.48 10.02 495 576501 28030 79139362
Alcohol poisoning 143.76 10.02 176 576820 4645 79162747
Multiple organ dysfunction syndrome 143.61 10.02 421 576575 119825 79047567
Cytomegalovirus infection 140.82 10.02 66 576930 42578 79124814
Weight increased 139.53 10.02 2799 574197 274587 78892805
Product use in unapproved indication 138.87 10.02 1151 575845 249208 78918184
Suspected suicide 138.24 10.02 263 576733 10313 79157079
Respiratory failure 137.69 10.02 757 576239 180154 78987238
Rhabdomyolysis 133.66 10.02 347 576649 102784 79064608
Pregnancy 128.25 10.02 457 576539 26394 79140998
Lactic acidosis 127.05 10.02 195 576801 70164 79097228
Abortion spontaneous 126.51 10.02 485 576511 29022 79138370
Intentional product use issue 126.38 10.02 1668 575328 150444 79016948
Thrombocytopenia 124.81 10.02 1271 575725 263988 78903404
Fibromyalgia 123.81 10.02 844 576152 63496 79103896
Neoplasm progression 122.23 10.02 116 576880 51566 79115826
Death 121.87 10.02 3144 573852 563370 78604022
Contusion 121.76 10.02 1627 575369 147149 79020243
Swollen joint count increased 120.65 10.02 403 576593 22524 79144868
Blood pressure systolic abnormal 120.64 10.02 335 576661 16912 79150480
Angioedema 119.66 10.02 230 576766 75805 79091587
Red blood cell sedimentation rate increased 119.06 10.02 651 576345 45291 79122101
Blood pressure diastolic abnormal 117.00 10.02 355 576641 18847 79148545
Ill-defined disorder 116.73 10.02 847 576149 65028 79102364
Psoriasis 115.65 10.02 1072 575924 88515 79078877
Blood pressure systolic increased 113.97 10.02 853 576143 66133 79101259
Joint effusion 107.86 10.02 331 576665 17683 79149709
Anaemia 107.07 10.02 2428 574568 442587 78724805
Infection 105.35 10.02 2389 574607 239323 78928069
Hyperglycaemia 105.32 10.02 219 576777 70116 79097276
Depressed level of consciousness 100.38 10.02 360 576636 96292 79071100
Hypoglycaemia 97.36 10.02 391 576605 101203 79066189
Grip strength decreased 95.85 10.02 362 576634 21507 79145885
Hyperkalaemia 90.72 10.02 472 576524 113926 79053466
Blood pressure diastolic decreased 88.52 10.02 443 576553 29773 79137619
Dyspnoea 86.24 10.02 5201 571795 851824 78315568
Hypotension 85.92 10.02 2477 574519 437840 78729552
Enthesopathy 85.71 10.02 230 576766 11378 79156014
Cholestasis 85.19 10.02 154 576842 51955 79115437
Drug ineffective for unapproved indication 85.05 10.02 150 576846 51088 79116304
Inflammation 84.15 10.02 1043 575953 92710 79074682
Serotonin syndrome 84.00 10.02 122 576874 44905 79122487
Disability assessment scale score increased 83.91 10.02 114 576882 3344 79164048
Palmar-plantar erythrodysaesthesia syndrome 83.59 10.02 70 576926 33064 79134328
C-reactive protein increased 83.51 10.02 1355 575641 127672 79039720
Cardiac failure congestive 83.36 10.02 645 576351 141757 79025635
Sepsis 83.25 10.02 1409 575587 268019 78899373
Leukopenia 82.46 10.02 499 576497 116014 79051378
Rheumatoid nodule 81.75 10.02 295 576701 17143 79150249
Anaphylactic shock 81.42 10.02 84 576912 35912 79131480
Off label use 80.78 10.02 5567 571429 901648 78265744
Cerebral haemorrhage 80.24 10.02 187 576809 57486 79109906
Myocardial infarction 80.20 10.02 898 576098 183231 78984161
Foot deformity 79.97 10.02 366 576630 23708 79143684
Syncope 79.42 10.02 872 576124 178577 78988815
Hepatocellular injury 78.39 10.02 140 576856 47453 79119939
Live birth 77.83 10.02 305 576691 18439 79148953
Osteoporosis 77.80 10.02 663 576333 53449 79113943
Hepatic failure 77.74 10.02 208 576788 61004 79106388
Disseminated intravascular coagulation 77.34 10.02 87 576909 35755 79131637
Alcohol use 77.03 10.02 131 576865 4700 79162692
Injection site erythema 76.79 10.02 885 576111 77312 79090080
Sedation complication 76.72 10.02 11 576985 15658 79151734
Fatigue 76.32 10.02 7759 569237 921968 78245424
Musculoskeletal pain 74.70 10.02 1097 575899 101257 79066135
Bone erosion 74.59 10.02 291 576705 17556 79149836
Juvenile idiopathic arthritis 74.43 10.02 128 576868 4635 79162757
Heart rate decreased 73.21 10.02 805 576191 69511 79097881
Condition aggravated 72.84 10.02 4374 572622 496750 78670642
Hyperhidrosis 72.81 10.02 722 576274 150770 79016622
Neurotoxicity 72.30 10.02 77 576919 32441 79134951
Tenosynovitis 71.96 10.02 262 576734 15292 79152100
Neuropathy peripheral 71.06 10.02 666 576330 140639 79026753
Blood cholesterol increased 70.30 10.02 920 576076 82800 79084592
Stomatitis 70.10 10.02 1470 575526 145287 79022105
Nausea 69.87 10.02 5971 571025 951225 78216167
Neuroleptic malignant syndrome 69.80 10.02 58 576938 27501 79139891
Agranulocytosis 69.30 10.02 138 576858 44892 79122500
Exposure to toxic agent 69.18 10.02 183 576813 8975 79158417
Diarrhoea 68.56 10.02 5464 571532 875025 78292367
Neutrophil count decreased 68.29 10.02 399 576597 93560 79073832
Dehydration 66.92 10.02 1329 575667 246858 78920534
Orthostatic hypotension 66.77 10.02 197 576799 55967 79111425
Cytokine release syndrome 66.69 10.02 98 576898 35900 79131492
Joint range of motion decreased 66.06 10.02 440 576556 32842 79134550
Electrocardiogram QT prolonged 65.06 10.02 385 576611 90001 79077391
Joint destruction 65.04 10.02 137 576859 5788 79161604
Polyarthritis 64.66 10.02 215 576781 11987 79155405
Rash 64.55 10.02 4938 572058 573420 78593972
Pyrexia 64.46 10.02 4140 572856 674569 78492823
Gastrointestinal disorder 63.99 10.02 1241 575755 120964 79046428
Joint stiffness 63.92 10.02 510 576486 40320 79127072
Pain in extremity 63.77 10.02 3237 573759 361301 78806091
Ventricular tachycardia 63.26 10.02 130 576866 41805 79125587
Altered state of consciousness 62.65 10.02 140 576856 43682 79123710
Injection site reaction 62.56 10.02 639 576357 54146 79113246
Vomiting 62.44 10.02 4066 572930 661762 78505630
Ascites 62.03 10.02 308 576688 75254 79092138
Caesarean section 61.28 10.02 215 576781 12320 79155072
Immune reconstitution inflammatory syndrome 60.61 10.02 13 576983 13828 79153564
Cognitive disorder 60.34 10.02 280 576716 69646 79097746
Injection site pruritus 60.22 10.02 517 576479 41766 79125626
Asthenia 60.20 10.02 3057 573939 508632 78658760
Cerebral infarction 59.69 10.02 153 576843 45523 79121869
Inappropriate antidiuretic hormone secretion 58.84 10.02 62 576934 26251 79141141
Blood creatinine increased 58.49 10.02 780 576216 154277 79013115
Venoocclusive liver disease 58.25 10.02 8 576988 11763 79155629
Joint laxity 57.98 10.02 78 576918 2266 79165126
Rash maculo-papular 57.47 10.02 210 576786 55868 79111524
Blood alcohol increased 57.10 10.02 58 576938 1237 79166155
Myalgia 56.93 10.02 972 576024 184669 78982723
Aspergillus infection 56.86 10.02 34 576962 19127 79148265
Sopor 56.28 10.02 95 576901 32915 79134477
Hypoxia 56.11 10.02 477 576519 102766 79064626
Second primary malignancy 56.08 10.02 17 576979 14333 79153059
Blood glucose increased 56.06 10.02 546 576450 114429 79052963
Posterior reversible encephalopathy syndrome 55.40 10.02 65 576931 26216 79141176
Melaena 54.82 10.02 240 576756 60650 79106742
Localised infection 54.34 10.02 461 576535 37114 79130278
Pathogen resistance 54.25 10.02 18 576978 14324 79153068
Gestational diabetes 54.04 10.02 132 576864 6161 79161231
Diabetic ketoacidosis 53.87 10.02 103 576893 34019 79133373
Basal cell carcinoma 53.76 10.02 458 576538 36917 79130475
Pulmonary fibrosis 53.51 10.02 521 576475 43591 79123801
Toxic epidermal necrolysis 53.27 10.02 156 576840 44425 79122967
Creatinine renal clearance decreased 53.26 10.02 36 576960 18966 79148426
Proteinuria 53.18 10.02 96 576900 32406 79134986
Thrombotic microangiopathy 52.89 10.02 41 576955 20128 79147264
Eosinophilia 52.50 10.02 161 576835 45184 79122208
Blood pressure diastolic increased 52.01 10.02 226 576770 14316 79153076
Osteonecrosis of jaw 51.83 10.02 151 576845 43075 79124317
Encephalopathy 51.79 10.02 281 576715 67116 79100276
Bronchopulmonary aspergillosis 51.59 10.02 51 576945 22243 79145149
Vision blurred 51.16 10.02 504 576492 105394 79061998
Myelosuppression 51.11 10.02 137 576859 40159 79127233
Respiratory distress 50.10 10.02 234 576762 58105 79109287
Hypokalaemia 49.91 10.02 737 576259 143303 79024089
No adverse event 49.83 10.02 123 576873 37069 79130323
Loss of personal independence in daily activities 49.46 10.02 1029 575967 101551 79065841
Red blood cell sedimentation rate 49.14 10.02 118 576878 5447 79161945
Transplant rejection 49.11 10.02 41 576955 19396 79147996
Disability 48.74 10.02 249 576747 16871 79150521
Asthma 48.64 10.02 686 576310 134409 79032983
Haematotoxicity 48.26 10.02 26 576970 15493 79151899
Ejection fraction decreased 48.19 10.02 112 576884 34465 79132927
Ventricular fibrillation 48.13 10.02 99 576897 31827 79135565
Atrial fibrillation 47.95 10.02 1078 575918 196808 78970584
Tendonitis 47.87 10.02 316 576680 23514 79143878
Platelet count decreased 47.87 10.02 1058 575938 193606 78973786
Blood creatine phosphokinase increased 47.83 10.02 281 576715 65809 79101583
Tongue disorder 46.82 10.02 213 576783 13762 79153630
Injection site pain 46.54 10.02 1250 575746 128588 79038804
Nodule 46.24 10.02 305 576691 22689 79144703
Anaphylactic reaction 45.91 10.02 386 576610 83357 79084035
Alanine aminotransferase abnormal 45.89 10.02 155 576841 8712 79158680
Extrapyramidal disorder 45.79 10.02 58 576938 22621 79144771
Acute graft versus host disease 45.66 10.02 9 576987 10158 79157234
Tumour lysis syndrome 45.50 10.02 64 576932 23875 79143517
Gamma-glutamyltransferase increased 45.39 10.02 222 576774 54458 79112934
Type 2 diabetes mellitus 45.18 10.02 621 576375 56501 79110891
Torsade de pointes 44.90 10.02 44 576952 19268 79148124
Somnolence 44.62 10.02 1352 575644 237629 78929763
Chronic kidney disease 44.38 10.02 288 576708 65866 79101526
Injection site swelling 44.30 10.02 529 576467 46603 79120789
Acute generalised exanthematous pustulosis 44.08 10.02 36 576960 17218 79150174
Unintentional medical device removal 44.03 10.02 3 576993 7709 79159683
Hallucination 44.01 10.02 402 576594 85343 79082049
Wrong technique in product usage process 43.97 10.02 333 576663 73542 79093850
Coronary artery disease 43.94 10.02 285 576711 65189 79102203
Clostridium difficile colitis 43.85 10.02 106 576890 32177 79135215
Tremor 43.67 10.02 918 576078 169165 78998227
Cardiac arrest 43.56 10.02 931 576065 171165 78996227
Cerebrovascular accident 43.53 10.02 826 576170 154466 79012926
Tachycardia 43.47 10.02 967 576029 176801 78990591
Ischaemic stroke 43.27 10.02 111 576885 33020 79134372
Adverse event 43.00 10.02 643 576353 59571 79107821
Speech disorder 42.94 10.02 225 576771 54220 79113172
Cardiogenic shock 42.92 10.02 157 576839 41757 79125635
Haemophagocytic lymphohistiocytosis 42.90 10.02 57 576939 21780 79145612
Body temperature decreased 42.65 10.02 387 576609 31758 79135634
Interstitial lung disease 42.25 10.02 567 576429 112033 79055359
Pulmonary embolism 42.18 10.02 933 576063 170721 78996671
Liver injury 42.17 10.02 609 576387 56005 79111387
Mobility decreased 41.46 10.02 1168 575828 121007 79046385
BK virus infection 41.25 10.02 7 576989 8797 79158595
Decreased appetite 41.12 10.02 2041 574955 340377 78827015
White blood cell count decreased 40.85 10.02 1043 575953 187245 78980147
Laryngitis 40.69 10.02 226 576770 15813 79151579
Disturbance in attention 40.60 10.02 209 576787 50592 79116800
Haemorrhage intracranial 40.53 10.02 80 576916 26113 79141279
Paradoxical drug reaction 40.43 10.02 3 576993 7182 79160210
Gastrointestinal haemorrhage 40.39 10.02 789 576207 146930 79020462
Septic shock 40.26 10.02 635 576361 122166 79045226
Erythema multiforme 40.14 10.02 41 576955 17610 79149782
Myoclonus 39.84 10.02 88 576908 27572 79139820
Latent tuberculosis 39.72 10.02 80 576916 3273 79164119
Disease recurrence 39.62 10.02 174 576822 43935 79123457
Synovial cyst 39.56 10.02 161 576835 9904 79157488
Stevens-Johnson syndrome 39.26 10.02 148 576848 39018 79128374
Toxic skin eruption 39.08 10.02 63 576933 22230 79145162
Angina pectoris 39.03 10.02 217 576779 51515 79115877
Blood pressure increased 39.02 10.02 1887 575109 209473 78957919
Haemoptysis 39.00 10.02 241 576755 55758 79111634
Dystonia 38.92 10.02 59 576937 21340 79146052
Psychotic disorder 38.61 10.02 161 576835 41241 79126151
Colorectal cancer 38.11 10.02 8 576988 8639 79158753
Neck deformity 37.83 10.02 56 576940 1781 79165611
Substance use disorder 37.74 10.02 40 576956 898 79166494
Anxiety 37.31 10.02 1445 575551 247067 78920325
Acute chest syndrome 37.18 10.02 51 576945 1510 79165882
Ear infection 37.13 10.02 397 576599 34035 79133357
Forced expiratory volume decreased 37.08 10.02 6 576990 7808 79159584
Tenderness 36.83 10.02 295 576701 23347 79144045
Metabolic acidosis 36.50 10.02 401 576595 82128 79085264
Lymphocyte count decreased 36.42 10.02 197 576799 47092 79120300
Graft versus host disease 36.38 10.02 33 576963 14993 79152399
Blood parathyroid hormone decreased 36.35 10.02 162 576834 10374 79157018
Chest discomfort 36.34 10.02 742 576254 137302 79030090
Bronchospasm 35.88 10.02 79 576917 24780 79142612
Injection site bruising 35.86 10.02 454 576542 40548 79126844
Status epilepticus 35.80 10.02 80 576916 24961 79142431
Acute respiratory distress syndrome 35.38 10.02 181 576815 43886 79123506
Cytopenia 35.36 10.02 58 576938 20325 79147067
Femur fracture 35.10 10.02 431 576565 38221 79129171
Shock 34.89 10.02 179 576817 43369 79124023
Acute myeloid leukaemia 34.81 10.02 111 576885 30774 79136618
Blood calcium decreased 34.72 10.02 116 576880 31703 79135689
Maternal exposure before pregnancy 34.69 10.02 89 576907 4284 79163108
Urinary retention 34.31 10.02 254 576742 56376 79111016
Dyskinesia 34.22 10.02 187 576809 44586 79122806
Balance disorder 34.17 10.02 506 576490 98351 79069041
Haemorrhage 34.12 10.02 459 576537 90659 79076733
Ulcer 33.93 10.02 349 576647 29623 79137769
Granuloma skin 33.90 10.02 144 576852 9030 79158362
Lip dry 33.77 10.02 209 576787 15209 79152183
Pancreatitis acute 33.76 10.02 215 576781 49389 79118003
Multiple sclerosis relapse 33.59 10.02 198 576798 46335 79121057
Product quality issue 33.54 10.02 129 576867 33811 79133581
Dysphagia 33.50 10.02 652 576344 121484 79045908
Jaundice 33.42 10.02 237 576759 53112 79114280
Fracture 33.41 10.02 271 576725 21530 79145862
Tuberculosis 33.28 10.02 206 576790 14992 79152400
Disorientation 33.23 10.02 292 576704 62484 79104908
Bursitis 33.12 10.02 401 576595 35443 79131949
Dizziness 33.05 10.02 3320 573676 523121 78644271
Irritability 33.03 10.02 169 576827 40975 79126417
Oropharyngeal pain 32.92 10.02 1030 575966 108323 79059069
Pre-eclampsia 32.91 10.02 119 576877 6922 79160470
Stress cardiomyopathy 32.87 10.02 20 576976 11146 79156246
Emotional distress 32.75 10.02 163 576833 39806 79127586
Facet joint syndrome 32.61 10.02 165 576831 11137 79156255
Wheelchair user 32.45 10.02 108 576888 6024 79161368
Cytomegalovirus viraemia 32.45 10.02 27 576969 12794 79154598
Exostosis 32.33 10.02 221 576775 16637 79150755
Neck mass 32.25 10.02 87 576909 4317 79163075
Delirium 32.16 10.02 425 576571 84202 79083190
Multiple fractures 32.03 10.02 129 576867 7897 79159495
Acute myocardial infarction 31.85 10.02 380 576616 76656 79090736
Metastases to bone 31.78 10.02 82 576914 24345 79143047
Blood bilirubin increased 31.66 10.02 316 576680 65916 79101476
Ankylosing spondylitis 31.65 10.02 173 576823 12032 79155360
Hyperthermia 31.59 10.02 51 576945 17986 79149406
Arrhythmia 31.56 10.02 287 576709 60985 79106407
Polyneuropathy 31.47 10.02 81 576915 24070 79143322
Hyperbilirubinaemia 31.37 10.02 83 576913 24435 79142957
Adenovirus infection 31.26 10.02 11 576985 8436 79158956
Pemphigoid 31.09 10.02 39 576957 15276 79152116
Klebsiella infection 30.91 10.02 41 576955 15679 79151713
Maternal exposure timing unspecified 30.64 10.02 102 576894 5690 79161702
Smear cervix abnormal 30.63 10.02 61 576935 2475 79164917
Hepatitis B reactivation 30.59 10.02 4 576992 6104 79161288
Fear of injection 30.53 10.02 121 576875 7353 79160039
Muscle rigidity 30.53 10.02 61 576935 19821 79147571
Limb deformity 30.50 10.02 75 576921 3515 79163877
Premature labour 30.47 10.02 131 576865 8259 79159133
Metastases to liver 30.37 10.02 104 576892 28210 79139182
Tachypnoea 30.33 10.02 124 576872 31939 79135453
Appendicolith 30.19 10.02 12 576984 8539 79158853
Peripheral venous disease 30.18 10.02 208 576788 15701 79151691
COVID-19 30.16 10.02 889 576107 156785 79010607
Joint dislocation 30.11 10.02 218 576778 16721 79150671
Acute graft versus host disease in skin 30.05 10.02 9 576987 7649 79159743
Coagulopathy 29.99 10.02 146 576850 35860 79131532
Arthritis infective 29.93 10.02 129 576867 8142 79159250
Panniculitis 29.86 10.02 172 576824 12199 79155193
Joint noise 29.60 10.02 79 576917 3895 79163497
Hypomagnesaemia 29.58 10.02 208 576788 46703 79120689
Shock haemorrhagic 29.57 10.02 63 576933 19997 79147395
Subdural haematoma 29.46 10.02 122 576874 31312 79136080
Premature rupture of membranes 29.41 10.02 80 576916 3989 79163403
Skin ulcer 29.39 10.02 553 576443 53597 79113795
Dermatitis acneiform 29.28 10.02 18 576978 9975 79157417
Pulmonary arterial hypertension 29.21 10.02 106 576890 28260 79139132
Injection site rash 29.06 10.02 226 576770 17728 79149664
Malignant mediastinal neoplasm 28.95 10.02 43 576953 1372 79166020
Rotator cuff repair 28.89 10.02 50 576946 1820 79165572
Haematoma 28.87 10.02 240 576756 51955 79115437
Road traffic accident 28.77 10.02 460 576536 43204 79124188
Joint injury 28.71 10.02 350 576646 30985 79136407
Labelled drug-drug interaction medication error 28.69 10.02 103 576893 27547 79139845
Product prescribing error 28.60 10.02 198 576798 44615 79122777
Seizure 28.55 10.02 1097 575899 187737 78979655
Therapeutic response decreased 28.52 10.02 659 576337 66194 79101198
Urticaria 28.41 10.02 1074 575922 184127 78983265
Premature delivery 28.38 10.02 277 576719 23190 79144202
Device difficult to use 28.32 10.02 33 576963 13352 79154040
Blood alkaline phosphatase increased 27.89 10.02 310 576686 63354 79104038
Nocardiosis 27.77 10.02 4 576992 5675 79161717
Retinitis 27.77 10.02 97 576899 5546 79161846
Fear 27.69 10.02 75 576921 21911 79145481
Deep vein thrombosis postoperative 27.61 10.02 152 576844 10600 79156792
Cystitis haemorrhagic 27.61 10.02 16 576980 9156 79158236
Agitation 27.44 10.02 532 576464 99183 79068209
Bradyphrenia 27.43 10.02 22 576974 10618 79156774
Anti-cyclic citrullinated peptide antibody 27.43 10.02 99 576897 5753 79161639
Spinal stenosis 27.37 10.02 202 576794 15589 79151803
Hemiplegia 27.35 10.02 41 576955 14898 79152494
Pleural effusion 27.29 10.02 821 576175 144441 79022951
Gastroenteritis viral 27.10 10.02 287 576709 24544 79142848
Skin papilloma 27.10 10.02 99 576897 5787 79161605
Lip swelling 26.99 10.02 179 576817 40732 79126660
Scleritis 26.98 10.02 81 576915 4275 79163117
Acute hepatic failure 26.92 10.02 119 576877 29994 79137398
Lupus-like syndrome 26.78 10.02 182 576814 13675 79153717
Hypertransaminasaemia 26.77 10.02 28 576968 11896 79155496
Pulmonary alveolar haemorrhage 26.75 10.02 26 576970 11431 79155961
Temperature regulation disorder 26.67 10.02 5 576991 5848 79161544
Blood pressure decreased 26.66 10.02 533 576463 98933 79068459
Purpura 26.61 10.02 64 576932 19463 79147929
Febrile bone marrow aplasia 26.59 10.02 33 576963 12987 79154405
Pseudomonas infection 26.56 10.02 71 576925 20832 79146560
Chronic graft versus host disease 26.56 10.02 8 576988 6773 79160619
Hyperthyroidism 26.32 10.02 78 576918 22131 79145261
Cardiac failure chronic 26.32 10.02 25 576971 11110 79156282
Mental status changes 26.28 10.02 334 576662 66625 79100767
Restlessness 26.07 10.02 213 576783 46279 79121113
Breast cancer stage I 26.07 10.02 8 576988 6692 79160700
Pneumatosis intestinalis 26.07 10.02 7 576989 6390 79161002
Anuria 26.04 10.02 72 576924 20891 79146501
Acute coronary syndrome 25.94 10.02 73 576923 21060 79146332
Face oedema 25.87 10.02 110 576886 28026 79139366
Tenosynovitis stenosans 25.83 10.02 64 576932 3014 79164378
Pancreatitis 25.83 10.02 345 576651 68230 79099162
Drug hypersensitivity 25.81 10.02 1838 575158 297078 78870314
Leukocytosis 25.80 10.02 196 576800 43259 79124133
Aphasia 25.79 10.02 215 576781 46517 79120875
Adjustment disorder with depressed mood 25.76 10.02 132 576864 8954 79158438
Hemiparesis 25.72 10.02 141 576855 33592 79133800
Akathisia 25.65 10.02 35 576961 13224 79154168
Peripheral sensory neuropathy 25.62 10.02 34 576962 12999 79154393
Cardiomyopathy 25.54 10.02 114 576882 28660 79138732
Synovial fluid analysis 25.26 10.02 54 576942 2305 79165087
Hypocalcaemia 25.21 10.02 235 576761 49689 79117703
Vertigo 25.14 10.02 350 576646 68732 79098660
Hyperuricaemia 25.06 10.02 29 576967 11770 79155622
Diabetes insipidus 24.90 10.02 4 576992 5233 79162159
Drug ineffective 24.83 10.02 8448 568548 1072465 78094927
Drug tolerance decreased 24.81 10.02 170 576826 12808 79154584
Bone disorder 24.80 10.02 229 576767 18884 79148508
Nephropathy toxic 24.72 10.02 71 576925 20348 79147044
Tardive dyskinesia 24.67 10.02 24 576972 10547 79156845
Bacteraemia 24.59 10.02 138 576858 32686 79134706
Ileus 24.40 10.02 102 576894 26109 79141283
Multiple-drug resistance 24.27 10.02 17 576979 8791 79158601
Lymphopenia 24.25 10.02 126 576870 30431 79136961
Hypothyroidism 24.20 10.02 252 576744 52140 79115252
Sciatica 24.20 10.02 356 576640 32866 79134526
Skin cancer 24.16 10.02 189 576807 14851 79152541
Dislocation of vertebra 24.12 10.02 117 576879 7763 79159629
Epstein-Barr virus infection 24.11 10.02 42 576954 14374 79153018
Drug level increased 23.94 10.02 178 576818 39473 79127919
Substance abuse 23.89 10.02 144 576852 10382 79157010
Tubulointerstitial nephritis 23.88 10.02 170 576826 38065 79129327
Alcohol withdrawal syndrome 23.84 10.02 48 576948 1963 79165429
Poor venous access 23.82 10.02 218 576778 17931 79149461
Bone pain 23.80 10.02 273 576723 55469 79111923
Infective pulmonary exacerbation of cystic fibrosis 23.79 10.02 35 576961 12816 79154576
Wound infection 23.76 10.02 272 576724 23719 79143673
Therapy partial responder 23.72 10.02 57 576939 17340 79150052
Metastases to central nervous system 23.66 10.02 52 576944 16323 79151069
Respiratory disorder 23.58 10.02 209 576787 44647 79122745
Rheumatoid lung 23.57 10.02 76 576920 4169 79163223
Bladder cancer 23.56 10.02 68 576928 19458 79147934
Hepatitis cholestatic 23.49 10.02 40 576956 13812 79153580
Muscle twitching 23.28 10.02 96 576900 24668 79142724
Glomerular filtration rate decreased 23.27 10.02 85 576911 22617 79144775
Fluid retention 23.21 10.02 360 576636 69449 79097943
Loose body in joint 23.19 10.02 37 576959 1258 79166134
Device related infection 23.15 10.02 149 576847 34145 79133247
Psychomotor hyperactivity 23.14 10.02 55 576941 16794 79150598
Foot fracture 23.03 10.02 252 576744 21729 79145663
Postmortem blood drug level abnormal 23.03 10.02 26 576970 628 79166764
Venoocclusive disease 22.89 10.02 3 576993 4570 79162822
Chest pain 22.74 10.02 1746 575250 280558 78886834
Drug tolerance 22.52 10.02 123 576873 8552 79158840
Dysgeusia 22.51 10.02 285 576711 56892 79110500
Graft versus host disease in skin 22.32 10.02 8 576988 6065 79161327
Pruritus genital 22.32 10.02 3 576993 4483 79162909
Abnormal behaviour 22.23 10.02 163 576833 36258 79131134
Palpitations 22.22 10.02 722 576274 125888 79041504
Flushing 22.18 10.02 478 576518 87790 79079602
Hypophosphataemia 22.14 10.02 72 576924 19841 79147551
Myocardial ischaemia 22.12 10.02 102 576894 25417 79141975
Synovial disorder 21.94 10.02 46 576950 1937 79165455
Antinuclear antibody positive 21.93 10.02 114 576882 7776 79159616
Device use error 21.93 10.02 12 576984 7089 79160303
Alcoholism 21.91 10.02 68 576928 3655 79163737
Enterocolitis 21.88 10.02 45 576951 14467 79152925
Sinus bradycardia 21.83 10.02 101 576895 25146 79142246
International normalised ratio increased 21.81 10.02 457 576539 84264 79083128
Eosinophil count increased 21.81 10.02 58 576938 17047 79150345
Dactylitis 21.75 10.02 56 576940 2701 79164691
Nasal polyps 21.74 10.02 13 576983 7314 79160078
Affective disorder 21.70 10.02 17 576979 8302 79159090
Obesity 21.65 10.02 366 576630 34759 79132633
Hypernatraemia 21.62 10.02 45 576951 14406 79152986
Heparin-induced thrombocytopenia 21.44 10.02 23 576973 9659 79157733
Sexual dysfunction 21.37 10.02 15 576981 7748 79159644
Cytomegalovirus infection reactivation 21.27 10.02 19 576977 8697 79158695
COVID-19 pneumonia 21.22 10.02 122 576874 28727 79138665
Skin exfoliation 21.19 10.02 276 576720 54824 79112568
Transplant dysfunction 21.17 10.02 13 576983 7208 79160184
Glycosylated haemoglobin increased 21.16 10.02 70 576926 19190 79148202
Endophthalmitis 21.14 10.02 10 576986 6418 79160974
Hepatitis acute 21.13 10.02 51 576945 15491 79151901
Pulmonary hypertension 21.10 10.02 234 576762 47846 79119546
Anhedonia 20.97 10.02 48 576948 14850 79152542
Hydrops foetalis 20.96 10.02 27 576969 751 79166641
Hypothermia 20.87 10.02 89 576907 22657 79144735
Hallucination, auditory 20.87 10.02 78 576918 20615 79146777
Acute respiratory failure 20.84 10.02 304 576692 59237 79108155
Hyperammonaemia 20.74 10.02 30 576966 11063 79156329
Oesophageal carcinoma 20.70 10.02 30 576966 11054 79156338
Cardiac failure acute 20.66 10.02 69 576927 18860 79148532
Jaundice cholestatic 20.63 10.02 31 576965 11253 79156139
Cytomegalovirus chorioretinitis 20.57 10.02 7 576989 5483 79161909
Parkinsonism 20.57 10.02 57 576939 16527 79150865
Hepatocellular carcinoma 20.46 10.02 21 576975 9000 79158392
Mouth ulceration 20.46 10.02 391 576605 38003 79129389
Feeling abnormal 20.44 10.02 942 576054 158257 79009135
Haematemesis 20.39 10.02 261 576735 52003 79115389
Hypoalbuminaemia 20.37 10.02 82 576914 21215 79146177
Haematuria 20.26 10.02 363 576633 68473 79098919
Ultrasound antenatal screen 20.18 10.02 25 576971 668 79166724
Deep vein thrombosis 20.18 10.02 694 576302 120225 79047167
Intentional overdose 20.17 10.02 949 576047 105011 79062381
End stage renal disease 20.07 10.02 36 576960 12184 79155208
Cleft lip and palate 20.04 10.02 25 576971 673 79166719
Hepatitis fulminant 20.03 10.02 14 576982 7248 79160144
Bone marrow failure 20.03 10.02 255 576741 50852 79116540
Fracture delayed union 20.00 10.02 46 576950 2064 79165328
Metastases to lung 19.97 10.02 66 576930 18097 79149295
Sleep terror 19.91 10.02 4 576992 4454 79162938
Diabetes mellitus 19.84 10.02 424 576572 77966 79089426
Rebound effect 19.84 10.02 14 576982 7212 79160180
Malignant melanoma 19.83 10.02 178 576818 14563 79152829
Device leakage 19.68 10.02 30 576966 10826 79156566
Oxygen saturation decreased 19.54 10.02 1131 575865 127916 79039476
Hyperlactacidaemia 19.51 10.02 8 576988 5587 79161805
Immunodeficiency 19.45 10.02 242 576754 21526 79145866
Finger deformity 19.42 10.02 106 576890 7368 79160024
Rhinitis allergic 19.39 10.02 37 576959 12232 79155160
Immune effector cell-associated neurotoxicity syndrome 19.38 10.02 9 576987 5839 79161553
Hyperprolactinaemia 19.27 10.02 5 576991 4671 79162721
Cardiotoxicity 19.27 10.02 37 576959 12202 79155190
Human antichimeric antibody positive 19.26 10.02 39 576957 1602 79165790
Hallucination, visual 19.25 10.02 148 576848 32581 79134811
Device expulsion 19.22 10.02 109 576887 25752 79141640
Gastric haemorrhage 19.21 10.02 51 576945 14999 79152393
Injection site warmth 19.00 10.02 177 576819 14630 79152762
Cholangitis 18.94 10.02 40 576956 12736 79154656
Ingrown hair 18.85 10.02 25 576971 716 79166676
Cyanosis 18.79 10.02 106 576890 25076 79142316
Obstructive airways disorder 18.63 10.02 142 576854 31317 79136075
Right ventricular failure 18.59 10.02 97 576899 23400 79143992
Pain in jaw 18.56 10.02 229 576767 45922 79121470
Toxic encephalopathy 18.53 10.02 34 576962 11406 79155986
Chemical submission 18.45 10.02 17 576979 320 79167072
Renal disorder 18.45 10.02 205 576791 41900 79125492
Dry skin 18.33 10.02 364 576632 67631 79099761
Mania 18.30 10.02 69 576927 18191 79149201
Pleuritic pain 18.24 10.02 131 576865 10021 79157371
Hepatic cancer 18.23 10.02 30 576966 10499 79156893
Type 1 diabetes mellitus 18.23 10.02 14 576982 6905 79160487
Virologic failure 18.22 10.02 4 576992 4187 79163205
Diabetes mellitus inadequate control 18.18 10.02 102 576894 24162 79143230
Lipase increased 17.99 10.02 60 576936 16406 79150986
Haemodynamic instability 17.87 10.02 65 576931 17317 79150075
Rash erythematous 17.84 10.02 302 576694 57467 79109925
Atrioventricular block complete 17.82 10.02 61 576935 16549 79150843
Hyperlipidaemia 17.80 10.02 113 576883 25980 79141412
Trisomy 18 17.78 10.02 22 576974 587 79166805
Influenza 17.77 10.02 1126 575870 128480 79038912
Hydrocephalus 17.72 10.02 23 576973 8877 79158515
Subarachnoid haemorrhage 17.71 10.02 104 576892 24361 79143031
Aspartate aminotransferase increased 17.67 10.02 821 576175 137820 79029572
Abdominal distension 17.66 10.02 697 576299 118953 79048439
Ankle arthroplasty 17.61 10.02 36 576960 1489 79165903
Renal injury 17.60 10.02 63 576933 16864 79150528
Generalised oedema 17.58 10.02 100 576896 23609 79143783
Candida infection 17.57 10.02 184 576812 38030 79129362
Body height below normal 17.56 10.02 43 576953 2010 79165382
Amylase increased 17.55 10.02 34 576962 11175 79156217
Rhinorrhoea 17.53 10.02 695 576301 75379 79092013
Multiple drug therapy 17.51 10.02 4 576992 4074 79163318
Dyspnoea exertional 17.39 10.02 488 576508 86585 79080807
Cross sensitivity reaction 17.28 10.02 3 576993 3709 79163683
Drug withdrawal syndrome 17.28 10.02 164 576832 34554 79132838
Oral herpes 17.26 10.02 287 576709 27167 79140225
Diplopia 17.13 10.02 157 576839 33309 79134083
Hepatic cirrhosis 17.09 10.02 351 576645 34555 79132837
Skin toxicity 17.06 10.02 21 576975 8293 79159099
Ileus paralytic 17.04 10.02 27 576969 9593 79157799
Foetal exposure during pregnancy 17.03 10.02 85 576911 5705 79161687
Injury 16.94 10.02 704 576292 76792 79090600
Pneumonia bacterial 16.91 10.02 77 576919 19254 79148138
Atrioventricular block 16.87 10.02 49 576947 13992 79153400
Polyhydramnios 16.86 10.02 38 576958 1682 79165710
Presyncope 16.78 10.02 203 576793 40851 79126541
Myopathy 16.77 10.02 84 576912 20479 79146913
Dyslipidaemia 16.76 10.02 37 576959 11596 79155796
Prostatic specific antigen increased 16.70 10.02 31 576965 10355 79157037
Blood lactate dehydrogenase increased 16.66 10.02 192 576804 38978 79128414
Post procedural infection 16.63 10.02 140 576856 11244 79156148
Breast feeding 16.56 10.02 23 576973 689 79166703
Visual acuity reduced 16.53 10.02 135 576861 29334 79138058
Herpes zoster 16.52 10.02 828 576168 92255 79075137
Short stature 16.44 10.02 23 576973 694 79166698
Chills 16.42 10.02 970 576026 159264 79008128
Strongyloidiasis 16.39 10.02 4 576992 3894 79163498
Foetal distress syndrome 16.38 10.02 19 576977 473 79166919
Potentiating drug interaction 16.34 10.02 24 576972 8795 79158597
Coronary artery bypass 16.31 10.02 12 576984 6050 79161342
Sleep disorder due to a general medical condition 16.31 10.02 51 576945 14226 79153166
Bronchitis 16.30 10.02 1126 575870 129518 79037874
Autoimmune disorder 16.30 10.02 188 576808 16424 79150968
Lower limb fracture 16.22 10.02 247 576749 22968 79144424
Intentional self-injury 16.20 10.02 153 576843 32266 79135126
Hepatic fibrosis 16.14 10.02 99 576897 7181 79160211
Blood urea increased 16.08 10.02 252 576744 48538 79118854
Acute lymphocytic leukaemia recurrent 16.08 10.02 7 576989 4717 79162675
Catatonia 16.06 10.02 24 576972 8732 79158660
Pneumonia 16.01 10.02 4393 572603 655853 78511539
Renal tubular disorder 16.00 10.02 14 576982 6472 79160920
Placental disorder 15.81 10.02 26 576970 907 79166485
Bronchial secretion retention 15.79 10.02 5 576991 4099 79163293
Atrial tachycardia 15.73 10.02 17 576979 7116 79160276
Blood ethanol 15.66 10.02 12 576984 173 79167219
Hypertriglyceridaemia 15.64 10.02 44 576952 12696 79154696
Colitis ulcerative 15.61 10.02 345 576651 34397 79132995
Injection site haemorrhage 15.60 10.02 286 576710 27584 79139808
Angina unstable 15.58 10.02 64 576932 16463 79150929
Polyuria 15.53 10.02 56 576940 14958 79152434
Acute graft versus host disease in intestine 15.41 10.02 5 576991 4036 79163356
Immunosuppressant drug level increased 15.37 10.02 26 576970 9001 79158391
Foot operation 15.36 10.02 82 576914 5651 79161741
Anti-neutrophil cytoplasmic antibody positive vasculitis 15.35 10.02 4 576992 3725 79163667
Left ventricular dysfunction 15.27 10.02 80 576916 19281 79148111
Kidney transplant rejection 15.25 10.02 32 576964 10214 79157178
Unresponsive to stimuli 15.23 10.02 298 576698 55490 79111902
Postoperative wound infection 15.19 10.02 152 576844 12809 79154583
Acute myeloid leukaemia recurrent 15.18 10.02 3 576993 3380 79164012
Laryngospasm 15.15 10.02 5 576991 3992 79163400
Endodontic procedure 15.13 10.02 49 576947 2694 79164698
Cyst 15.12 10.02 160 576836 13680 79153712
Knee operation 15.11 10.02 83 576913 5783 79161609
Mental disorder 15.10 10.02 149 576847 31153 79136239
Epistaxis 15.10 10.02 656 576340 110859 79056533
Dysarthria 15.08 10.02 373 576623 67249 79100143
Radiation inflammation 15.04 10.02 25 576971 880 79166512
Haematocrit decreased 15.04 10.02 564 576432 60748 79106644
Coronary arterial stent insertion 14.96 10.02 13 576983 6031 79161361
Normal newborn 14.95 10.02 95 576901 6977 79160415
Drug dose omission by device 14.81 10.02 14 576982 6236 79161156
Sickle cell anaemia 14.78 10.02 21 576975 643 79166749
Aplasia 14.77 10.02 21 576975 7799 79159593
Capillary leak syndrome 14.72 10.02 5 576991 3920 79163472
Maternal exposure during breast feeding 14.69 10.02 49 576947 2736 79164656
Respiration abnormal 14.62 10.02 21 576975 7767 79159625
Antibody test positive 14.62 10.02 49 576947 2743 79164649
Stillbirth 14.55 10.02 62 576934 3893 79163499
Systemic inflammatory response syndrome 14.52 10.02 39 576957 11426 79155966
Metastasis 14.52 10.02 17 576979 6863 79160529
Onychomycosis 14.50 10.02 106 576890 8155 79159237
Pneumothorax 14.44 10.02 133 576863 28190 79139202
Paralysis 14.40 10.02 48 576948 13129 79154263
Intentional product misuse 14.40 10.02 834 576162 94331 79073061
Induced labour 14.37 10.02 24 576972 848 79166544
Erectile dysfunction 14.32 10.02 56 576940 14608 79152784
Polydipsia 14.28 10.02 16 576980 6589 79160803
Diaphragmatic disorder 14.28 10.02 36 576960 1714 79165678
Lacrimal disorder 14.24 10.02 18 576978 491 79166901
Type I hypersensitivity 14.22 10.02 7 576989 4391 79163001
Osteonecrosis 14.18 10.02 150 576846 30945 79136447
Gastric cancer 14.16 10.02 33 576963 10146 79157246
Personality change 14.12 10.02 33 576963 10137 79157255
Hypercapnia 14.08 10.02 27 576969 8908 79158484
Lymph gland infection 14.07 10.02 19 576977 554 79166838
Intestinal ischaemia 14.06 10.02 49 576947 13221 79154171
Hyperpyrexia 14.02 10.02 14 576982 6078 79161314
Human herpesvirus 6 infection 13.97 10.02 11 576985 5359 79162033
Pharyngitis streptococcal 13.71 10.02 128 576868 10586 79156806
Cushingoid 13.71 10.02 117 576879 9435 79157957
Oliguria 13.66 10.02 66 576930 16243 79151149
Skin necrosis 13.64 10.02 195 576801 17892 79149500
Haemorrhage in pregnancy 13.60 10.02 31 576965 1383 79166009
Palmoplantar keratoderma 13.48 10.02 5 576991 3711 79163681
Nephrotic syndrome 13.42 10.02 39 576957 11135 79156257
Surgery 13.36 10.02 321 576675 32445 79134947
Troponin increased 13.34 10.02 83 576913 19172 79148220
Appendicitis 13.21 10.02 92 576904 20702 79146690
Abortion incomplete 13.17 10.02 3 576993 3061 79164331
Complications of transplanted kidney 13.14 10.02 16 576980 6350 79161042
Reversible cerebral vasoconstriction syndrome 13.13 10.02 3 576993 3054 79164338
Ligament rupture 13.11 10.02 54 576942 3340 79164052
Lymphatic fistula 13.10 10.02 22 576974 781 79166611
Carotid artery thrombosis 13.10 10.02 3 576993 3050 79164342
Renal cancer 13.05 10.02 45 576951 12181 79155211
Tuberculin test positive 12.99 10.02 54 576942 3354 79164038
Heart rate irregular 12.98 10.02 319 576677 32360 79135032
Bradykinesia 12.94 10.02 24 576972 8019 79159373
Hepatotoxicity 12.92 10.02 278 576718 51074 79116318
Complication of device removal 12.87 10.02 6 576990 3883 79163509
Wound infection pseudomonas 12.87 10.02 33 576963 1588 79165804
Dermatitis exfoliative 12.86 10.02 38 576958 10791 79156601
Spinal disorder 12.84 10.02 122 576874 10138 79157254
Threatened labour 12.82 10.02 19 576977 605 79166787
Metastases to meninges 12.80 10.02 5 576991 3596 79163796
Pulmonary function test abnormal 12.80 10.02 7 576989 4137 79163255
Sensitisation 12.80 10.02 4 576992 3307 79164085
Prescribed overdose 12.80 10.02 362 576634 37521 79129871
Weight decreased 12.78 10.02 2830 574166 352368 78815024
Pseudomembranous colitis 12.78 10.02 12 576984 5362 79162030
Acidosis 12.77 10.02 87 576909 19675 79147717
Accidental exposure to product 12.75 10.02 155 576841 31167 79136225
Brain oedema 12.72 10.02 119 576877 25144 79142248
Musculoskeletal disorder 12.68 10.02 222 576774 21226 79146166
Panic attack 12.65 10.02 113 576883 24103 79143289
Colitis microscopic 12.63 10.02 38 576958 10730 79156662
Atrial flutter 12.62 10.02 98 576898 21527 79145865
Hypomania 12.59 10.02 22 576974 7522 79159870
Alanine aminotransferase increased 12.53 10.02 1009 575987 161561 79005831
Product administered to patient of inappropriate age 12.51 10.02 13 576983 5540 79161852
Electrolyte imbalance 12.50 10.02 153 576843 30728 79136664
Clear cell renal cell carcinoma 12.43 10.02 44 576952 2532 79164860
Hepatitis B 12.42 10.02 26 576970 8306 79159086
Epstein-Barr virus associated lymphoproliferative disorder 12.40 10.02 5 576991 3527 79163865
C-reactive protein decreased 12.39 10.02 45 576951 2623 79164769
Intracranial pressure increased 12.38 10.02 26 576970 8296 79159096
Swollen tongue 12.36 10.02 225 576771 42345 79125047
Ischaemic cardiomyopathy 12.35 10.02 23 576973 7672 79159720
Femoral hernia incarcerated 12.34 10.02 22 576974 820 79166572
Osteoporotic fracture 12.30 10.02 62 576934 4178 79163214
Vascular device infection 12.24 10.02 36 576960 10240 79157152
Frequent bowel movements 12.23 10.02 290 576706 29249 79138143
Cervical incompetence 12.22 10.02 17 576979 510 79166882
Joint lock 12.21 10.02 51 576945 3174 79164218
Neurologic neglect syndrome 12.19 10.02 3 576993 2904 79164488
Hypertensive crisis 12.18 10.02 94 576902 20676 79146716
Delusion 12.18 10.02 92 576904 20331 79147061
Neutropenic colitis 12.15 10.02 14 576982 5693 79161699
Dermatitis atopic 12.15 10.02 35 576961 10021 79157371
Ketoacidosis 12.14 10.02 24 576972 7830 79159562
Injection site urticaria 12.07 10.02 144 576852 12682 79154710
Bone density abnormal 12.07 10.02 49 576947 3011 79164381
Oligoarthritis 12.03 10.02 20 576976 704 79166688
Small for dates baby 12.02 10.02 16 576980 460 79166932
Blood folate increased 12.00 10.02 17 576979 519 79166873
Lower respiratory tract congestion 11.99 10.02 59 576937 3938 79163454
Opiates positive 11.95 10.02 24 576972 980 79166412
Procedural pain 11.94 10.02 108 576888 22976 79144416
Anal fissure 11.94 10.02 96 576900 7607 79159785
Human anti-human antibody test 11.90 10.02 15 576981 408 79166984
C-reactive protein 11.87 10.02 69 576927 4910 79162482
Abortion threatened 11.85 10.02 15 576981 410 79166982
Joint warmth 11.81 10.02 32 576964 1592 79165800
Psychiatric decompensation 11.80 10.02 7 576989 3956 79163436
Breast abscess 11.80 10.02 30 576966 1436 79165956
Red blood cell count decreased 11.79 10.02 519 576477 56994 79110398
Delirium tremens 11.75 10.02 20 576976 718 79166674
Lymphoedema 11.74 10.02 48 576948 12365 79155027
Progressive multifocal leukoencephalopathy 11.72 10.02 94 576902 20506 79146886
Cyst rupture 11.72 10.02 19 576977 655 79166737
Systemic candida 11.71 10.02 19 576977 6687 79160705
Immune thrombocytopenia 11.69 10.02 78 576918 17727 79149665
Hypogammaglobulinaemia 11.68 10.02 51 576945 12900 79154492
Hypervolaemia 11.67 10.02 228 576768 42462 79124930
Withdrawal syndrome 11.66 10.02 131 576865 26723 79140669
Persecutory delusion 11.63 10.02 11 576985 4898 79162494
Injection site extravasation 11.63 10.02 114 576882 9555 79157837
Genital haemorrhage 11.61 10.02 17 576979 6238 79161154
Spondylitis 11.56 10.02 66 576930 4665 79162727
Vascular purpura 11.52 10.02 4 576992 3094 79164298
Eating disorder 11.52 10.02 95 576901 20602 79146790
Schizophrenia 11.52 10.02 65 576931 15375 79152017
Infusion site pain 11.51 10.02 58 576938 14118 79153274
Product monitoring error 11.51 10.02 30 576966 8876 79158516
Multiple allergies 11.50 10.02 38 576958 10422 79156970
Depression 11.47 10.02 1383 575613 215407 78951985
Lip blister 11.47 10.02 45 576951 2722 79164670
Cogwheel rigidity 11.46 10.02 4 576992 3084 79164308
Tumour haemorrhage 11.42 10.02 8 576988 4136 79163256
Walking aid user 11.41 10.02 118 576878 10030 79157362
Oesophageal fibrosis 11.40 10.02 10 576986 176 79167216
Euglycaemic diabetic ketoacidosis 11.39 10.02 20 576976 6824 79160568
Transaminases increased 11.38 10.02 286 576710 51457 79115935
Blood ethanol increased 11.33 10.02 19 576977 674 79166718
Nail injury 11.32 10.02 18 576978 610 79166782
Muscle spasticity 11.31 10.02 100 576896 21375 79146017
Hypophagia 11.30 10.02 246 576750 45121 79122271
Ventricular arrhythmia 11.25 10.02 30 576966 8810 79158582
Accidental overdose 11.24 10.02 210 576786 39371 79128021
Placental insufficiency 11.22 10.02 25 576971 1098 79166294
Toothache 11.20 10.02 205 576791 19765 79147627
Joint ankylosis 11.19 10.02 38 576958 2142 79165250
Osteopenia 11.19 10.02 191 576805 18173 79149219
Ventricular extrasystoles 11.17 10.02 90 576906 19614 79147778
Defaecation disorder 11.17 10.02 19 576977 682 79166710
Hypoxic-ischaemic encephalopathy 11.16 10.02 25 576971 7795 79159597
Dermatitis bullous 11.16 10.02 59 576937 14186 79153206
Retinal haemorrhage 11.14 10.02 27 576969 8190 79159202
Eyelid oedema 11.11 10.02 56 576940 13631 79153761
Drug specific antibody 11.10 10.02 43 576953 2585 79164807
Complication of device insertion 11.08 10.02 18 576978 6332 79161060
Bacterial sepsis 11.07 10.02 27 576969 8171 79159221
Cirrhosis alcoholic 11.06 10.02 24 576972 1035 79166357
Lung transplant 11.06 10.02 10 576986 4551 79162841
Amphetamines positive 11.04 10.02 13 576983 329 79167063
Alcoholic 10.99 10.02 6 576990 46 79167346
Psychomotor skills impaired 10.99 10.02 13 576983 5224 79162168
Arthritis bacterial 10.99 10.02 108 576888 9058 79158334
Embolism 10.90 10.02 58 576938 13924 79153468
Rhinovirus infection 10.89 10.02 26 576970 7927 79159465
Myofascial pain syndrome 10.89 10.02 36 576960 2001 79165391
Neutrophilia 10.88 10.02 26 576970 7925 79159467
Postmortem blood drug level 10.86 10.02 13 576983 335 79167057
Upper respiratory tract inflammation 10.84 10.02 8 576988 4027 79163365
Hepatitis E virus test positive 10.79 10.02 12 576984 285 79167107
Gestational hypertension 10.76 10.02 34 576962 1845 79165547
Iodine allergy 10.74 10.02 17 576979 574 79166818
Steroid diabetes 10.72 10.02 6 576990 3500 79163892
Lung opacity 10.69 10.02 13 576983 5161 79162231
Benign ovarian tumour 10.65 10.02 13 576983 342 79167050
Cryptococcosis 10.65 10.02 6 576990 3487 79163905
Victim of sexual abuse 10.65 10.02 16 576980 516 79166876
Metastases to lymph nodes 10.61 10.02 39 576957 10358 79157034
Rales 10.60 10.02 93 576903 19908 79147484
Macrocytosis 10.57 10.02 45 576951 2825 79164567
Accidental exposure to product by child 10.51 10.02 4 576992 2922 79164470
Pancytopenia 10.47 10.02 1361 575635 164384 79003008
Kidney infection 10.46 10.02 219 576777 21632 79145760
Hepatic encephalopathy 10.45 10.02 118 576878 24048 79143344
Immunosuppression 10.45 10.02 140 576856 12663 79154729
Tooth infection 10.45 10.02 193 576803 18639 79148753
Blood phosphorus increased 10.43 10.02 39 576957 10308 79157084
Colitis 10.39 10.02 429 576567 72878 79094514
Pulseless electrical activity 10.35 10.02 60 576936 14100 79153292
Metabolic disorder 10.30 10.02 33 576963 9137 79158255
Spinal osteoarthritis 10.29 10.02 176 576820 16751 79150641
Sputum discoloured 10.28 10.02 104 576892 21639 79145753
Lip and/or oral cavity cancer 10.26 10.02 24 576972 1089 79166303
Blindness 10.25 10.02 144 576852 28239 79139153
Autonomic nervous system imbalance 10.25 10.02 11 576985 4619 79162773
Mucosal inflammation 10.15 10.02 445 576551 75135 79092257
Immune-mediated hepatitis 10.15 10.02 7 576989 3649 79163743
Respiratory tract infection viral 10.14 10.02 59 576937 4200 79163192
Hypopituitarism 10.13 10.02 6 576990 3393 79163999
Blood loss anaemia 10.12 10.02 68 576928 15430 79151962
Immune-mediated enterocolitis 10.12 10.02 12 576984 4818 79162574
Dry eye 10.11 10.02 344 576652 36587 79130805
Tooth disorder 10.10 10.02 255 576741 25978 79141414
Hospitalisation 10.09 10.02 568 576428 93668 79073724
Bone density increased 10.08 10.02 20 576976 809 79166583
Skin neoplasm excision 10.08 10.02 23 576973 1027 79166365
Abortion missed 10.06 10.02 26 576970 1257 79166135
Cardiac dysfunction 10.05 10.02 9 576987 4115 79163277
Aphthous ulcer 10.05 10.02 175 576821 16714 79150678
Laryngeal oedema 10.04 10.02 28 576968 8101 79159291
Hepatitis E antibody positive 10.03 10.02 11 576985 257 79167135
Pulmonary pain 10.03 10.02 61 576935 4412 79162980
Skin ulcer haemorrhage 10.03 10.02 16 576980 544 79166848
Haemorrhage subcutaneous 10.02 10.02 12 576984 4797 79162595

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000975 Antioxidants
MeSH PA D018977 Micronutrients
MeSH PA D020011 Protective Agents
MeSH PA D014815 Vitamins

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4017691 VUID
N0000179281 NUI
D01735 KEGG_DRUG
52225-20-4 SECONDARY_CAS_RN
7695-91-2 SECONDARY_CAS_RN
4017635 VANDF
4017691 VANDF
4017773 VANDF
4020803 VANDF
C1999896 UMLSCUI
CHEBI:32321 CHEBI
CHEMBL3989859 ChEMBL_ID
CHEMBL3989727 ChEMBL_ID
D024502 MESH_DESCRIPTOR_UI
DB14003 DRUGBANK_ID
86472 PUBCHEM_CID
DB14002 DRUGBANK_ID
DB11635 DRUGBANK_ID
1046243 RXNORM
7433 MMSL
001021 NDDF
007607 NDDF
009945 NDDF
395830006 SNOMEDCT_US
C0606070 UMLSCUI
CHEMBL1047 ChEMBL_ID
WR1WPI7EW8 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 11 [iU] ORAL Unapproved drug other 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 30 [iU] ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 30 [iU] ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 30 [iU] ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 30 [iU] ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 30 [iU] ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 30 [iU] ORAL Unapproved drug other 11 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 30 [iU] ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 9 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 9 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 30 [iU] ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 9 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 9 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 30 [iU] ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 30 [iU] ORAL UNAPPROVED DRUG OTHER 10 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 30 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 22 mg ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 22 [iU] ORAL UNAPPROVED DRUG OTHER 7 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 30 mg ORAL unapproved drug other 15 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 30 mg ORAL unapproved drug other 15 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 14 13925-117 TABLET, CHEWABLE 30 [iU] ORAL unapproved drug other 16 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 15338-522 TABLET, FILM COATED 22 mg ORAL unapproved drug other 8 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-100 LIQUID 5 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-101 LIQUID 12 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora FE Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 14 15370-102 LIQUID 5 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
TriStart DHA HUMAN PRESCRIPTION DRUG LABEL 15 15370-250 CAPSULE, LIQUID FILLED 15 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 17856-0668 TABLET, FILM COATED 22 mg ORAL UNAPPROVED DRUG OTHER 6 sections
SimmyungSaengMoSuHair tonic HUMAN OTC DRUG LABEL 3 32819-1001 LIQUID 3 mL TOPICAL unapproved drug other 8 sections
Prenatal Plus Vitamins HUMAN PRESCRIPTION DRUG LABEL 15 39328-106 TABLET 10 mg ORAL UNAPPROVED DRUG OTHER 7 sections
PNV-Select HUMAN PRESCRIPTION DRUG LABEL 18 42192-320 TABLET, FILM COATED 10 [iU] ORAL unapproved drug other 10 sections