biotin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
373 58-85-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • biotin
  • coenzyme R
  • D-Biotin
A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.
  • Molecular weight: 244.31
  • Formula: C10H16N2O3S
  • CLOGP: -0.08
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 78.43
  • ALOGS: -2.30
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.22 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 43 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.01 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Fatigue 103.01 12.12 801 32282 887227 62568712
Toxicity to various agents 86.22 12.12 13 33070 247237 63208702
Synovitis 84.09 12.12 3 33080 186915 63269024
Pleural thickening 83.07 12.12 37 33046 2846 63453093
Blood magnesium increased 81.21 12.12 37 33046 3001 63452938
Presbyacusis 80.09 12.12 36 33047 2829 63453110
Product dose omission issue 77.39 12.12 283 32800 234030 63221909
Pleural fibrosis 76.50 12.12 37 33046 3435 63452504
Contraindicated product administered 72.41 12.12 13 33070 217635 63238304
COVID-19 71.35 12.12 172 32911 112931 63343008
Deafness neurosensory 70.23 12.12 39 33044 4816 63451123
Hand deformity 70.22 12.12 3 33080 159454 63296485
Maternal exposure during pregnancy 65.37 12.12 17 33066 220045 63235894
Glossodynia 63.28 12.12 9 33074 178867 63277072
Epigastric discomfort 60.62 12.12 40 33043 6740 63449199
Alopecia 59.73 12.12 339 32744 337197 63118742
Dry eye 58.40 12.12 88 32995 40673 63415266
General physical health deterioration 57.12 12.12 17 33066 201385 63254554
Systemic lupus erythematosus 56.82 12.12 19 33064 208899 63247040
Cyst 55.19 12.12 51 33032 14048 63441891
Completed suicide 49.98 12.12 8 33075 145665 63310274
Headache 48.89 12.12 524 32559 632717 62823222
White blood cell count decreased 45.84 12.12 168 32915 138936 63317003
Back pain 40.71 12.12 256 32827 263889 63192050
Osteopenia 39.28 12.12 50 33033 19735 63436204
Diarrhoea 37.97 12.12 552 32531 714814 62741125
Acute kidney injury 37.91 12.12 49 33034 263366 63192573
Onychoclasis 37.79 12.12 29 33054 6193 63449746
Muscle spasms 37.49 12.12 171 32912 155979 63299960
Drug interaction 36.86 12.12 39 33044 229092 63226847
Blood potassium increased 35.92 12.12 46 33037 18263 63437676
Feeling abnormal 33.05 12.12 159 32924 148233 63307706
Drug ineffective 31.59 12.12 371 32712 1044394 62411545
Sinusitis 31.45 12.12 214 32869 226439 63229500
Hepatic enzyme increased 30.82 12.12 36 33047 202292 63253647
Wound 30.76 12.12 24 33059 163239 63292700
C-reactive protein increased 30.74 12.12 6 33077 94701 63361238
Full blood count decreased 30.14 12.12 51 33032 25973 63429966
Bone cyst 29.61 12.12 17 33066 2237 63453702
Pre-existing condition improved 28.79 12.12 28 33055 8216 63447723
Multiple sclerosis relapse 28.71 12.12 72 33011 48406 63407533
Osteosclerosis 27.83 12.12 20 33063 3868 63452071
Drug abuse 27.21 12.12 3 33080 72515 63383424
Lower respiratory tract infection 26.81 12.12 18 33065 132289 63323650
Exposure during pregnancy 26.70 12.12 25 33058 155522 63300417
Flatulence 26.55 12.12 57 33026 34645 63421294
Folliculitis 26.15 12.12 3 33080 70314 63385625
Multiple sclerosis 25.92 12.12 46 33037 24326 63431613
Intentional overdose 25.59 12.12 4 33079 74148 63381791
Skin lesion 25.29 12.12 52 33031 30669 63425270
Weight decreased 25.06 12.12 237 32846 276561 63179378
Febrile neutropenia 24.15 12.12 16 33067 118433 63337506
Memory impairment 24.14 12.12 113 32970 104145 63351794
Gastrooesophageal reflux disease 23.88 12.12 106 32977 95533 63360406
Constipation 23.65 12.12 199 32884 224744 63231195
Hot flush 23.31 12.12 69 33014 51090 63404849
Dermatitis atopic 23.25 12.12 27 33056 9697 63446242
Drug intolerance 23.02 12.12 83 33000 308578 63147361
Hyponatraemia 22.97 12.12 15 33068 111885 63344054
Stress 22.85 12.12 82 33001 67085 63388854
Dizziness 22.80 12.12 332 32751 429593 63026346
Cardiac arrest 22.51 12.12 10 33073 92535 63363404
Illness 22.19 12.12 66 33017 48993 63406946
Injection site pain 21.98 12.12 129 32954 129671 63326268
Hypoaesthesia 21.58 12.12 156 32927 168237 63287702
Liver injury 21.49 12.12 3 33080 60517 63395422
Injection site erythema 21.38 12.12 93 32990 83081 63372858
Swelling 21.23 12.12 73 33010 275305 63180634
Urinary tract infection 21.22 12.12 221 32862 264463 63191476
Infusion site haemorrhage 21.08 12.12 19 33064 5067 63450872
Surgery 20.91 12.12 53 33030 35859 63420080
Dry skin 20.68 12.12 71 33012 56816 63399123
Psoriasis 20.68 12.12 95 32988 86862 63369077
Migraine 20.36 12.12 107 32976 103239 63352700
Product use issue 20.19 12.12 54 33029 220466 63235473
Nausea 19.96 12.12 584 32499 853887 62602052
Pruritus 19.90 12.12 281 32802 361172 63094767
Arthropathy 19.65 12.12 60 33023 234732 63221207
Confusional state 19.37 12.12 61 33022 236319 63219620
Infusion site erythema 19.32 12.12 27 33056 11652 63444287
Osteoarthritis 18.98 12.12 99 32984 95244 63360695
Fall 18.87 12.12 298 32785 392036 63063903
Burning sensation 18.14 12.12 66 33017 54341 63401598
Overdose 18.03 12.12 20 33063 115058 63340881
Depressed level of consciousness 18.02 12.12 5 33078 62073 63393866
Somnolence 17.68 12.12 156 32927 178529 63277410
Pain in extremity 17.16 12.12 255 32828 331231 63124708
Flushing 17.09 12.12 81 33002 75006 63380933
Infusion related reaction 17.01 12.12 68 33015 245453 63210486
Hypokalaemia 16.31 12.12 18 33065 103786 63352153
Sinus disorder 16.17 12.12 38 33045 24515 63431424
Eosinophilic pleural effusion 15.93 12.12 4 33079 49 63455890
Dysgeusia 15.86 12.12 57 33026 46653 63409286
Nail disorder 15.73 12.12 26 33057 12989 63442950
Balance disorder 15.67 12.12 86 32997 84336 63371603
Increased tendency to bruise 15.42 12.12 23 33060 10529 63445410
Type 2 diabetes mellitus 15.38 12.12 7 33076 63861 63392078
Pancytopenia 15.02 12.12 17 33066 96916 63359023
Spinal operation 15.01 12.12 20 33063 8251 63447688
Vision blurred 14.69 12.12 90 32993 91834 63364105
Injection site mass 14.68 12.12 31 33052 18625 63437314
Gastrointestinal candidiasis 14.61 12.12 5 33078 189 63455750
Paraesthesia 14.48 12.12 135 32948 156831 63299108
Limb discomfort 14.42 12.12 41 33042 29675 63426264
Infusion site pain 14.41 12.12 29 33054 16840 63439099
Upper respiratory tract infection 14.18 12.12 82 33001 81965 63373974
Injection site bruising 14.11 12.12 51 33032 41859 63414080
Bone hypertrophy 14.03 12.12 6 33077 418 63455521
Infusion site swelling 13.85 12.12 21 33062 9749 63446190
Injection site swelling 13.63 12.12 55 33028 47517 63408422
Milk allergy 13.63 12.12 5 33078 232 63455707
Electrocardiogram QT prolonged 13.61 12.12 7 33076 59523 63396416
Muscle strain 13.50 12.12 19 33064 8255 63447684
Therapeutic response unexpected 13.42 12.12 30 33053 18729 63437210
Seasonal allergy 13.34 12.12 32 33051 20918 63435021
Vitamin D deficiency 13.23 12.12 25 33058 13867 63442072
Blood cholesterol abnormal 13.13 12.12 11 33072 2660 63453279
Food interaction 12.86 12.12 7 33076 831 63455108
Retinal disorder 12.80 12.12 9 33074 1681 63454258
Death 12.79 12.12 129 32954 374252 63081687
Gastrointestinal bacterial infection 12.74 12.12 7 33076 847 63455092
Polyarteritis nodosa 12.63 12.12 5 33078 286 63455653
Bradycardia 12.29 12.12 12 33071 73215 63382724
Acne 12.15 12.12 33 33050 23260 63432679
Drug-induced liver injury 12.13 12.12 3 33080 40219 63415720

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Fractional exhaled nitric oxide increased 202.41 23.51 44 5253 1038 34950596
Plantar fasciitis 163.24 23.51 42 5255 2074 34949560
Sensation of foreign body 161.10 23.51 44 5253 2739 34948895
Myoglobin blood increased 157.49 23.51 44 5253 2979 34948655
Brain natriuretic peptide increased 130.30 23.51 44 5253 5615 34946019
Secretion discharge 124.58 23.51 43 5254 5862 34945772
Appendicolith 101.85 23.51 41 5256 8560 34943074
Obstructive airways disorder 93.39 23.51 46 5251 15448 34936186
Exostosis 90.42 23.51 32 5265 4691 34946943
Dysphonia 86.10 23.51 50 5247 23333 34928301
Appendicitis 80.51 23.51 41 5256 14766 34936868
Dyspnoea exertional 75.24 23.51 58 5239 43221 34908413
Blood phosphorus increased 75.14 23.51 32 5265 7689 34943945
Stress 69.36 23.51 48 5249 30299 34921335
Ventricular fibrillation 68.76 23.51 43 5254 22911 34928723
Eosinophilia 65.93 23.51 44 5253 26178 34925456
Abdominal distension 65.79 23.51 61 5236 58431 34893203
Cardiogenic shock 62.94 23.51 43 5254 26575 34925059
Cardiac disorder 60.51 23.51 51 5246 43075 34908559
Wheezing 58.17 23.51 49 5248 41353 34910281
Muscle spasms 53.10 23.51 61 5236 74940 34876694
Nasopharyngitis 49.68 23.51 57 5240 69911 34881723
Dry mouth 49.29 23.51 39 5258 30126 34921508
Chest discomfort 46.64 23.51 49 5248 54481 34897153
Coronary artery disease 46.01 23.51 46 5251 48259 34903375
Myasthenia gravis 45.99 23.51 22 5275 6918 34944716
Ascites 45.56 23.51 45 5252 46526 34905108
Blood uric acid increased 41.94 23.51 23 5274 9601 34942033
Pneumothorax 36.25 23.51 27 5270 19065 34932569
Iron deficiency 35.47 23.51 17 5280 5364 34946270
Hyperphosphataemia 35.41 23.51 16 5281 4421 34947213
Blood cholesterol increased 32.35 23.51 26 5271 20517 34931117
Drug therapy 30.76 23.51 10 5287 1131 34950503
Needle fatigue 29.04 23.51 9 5288 872 34950762
Cough 28.30 23.51 67 5230 150073 34801561
Analgesic therapy 27.93 23.51 9 5288 989 34950645
Relapsing-remitting multiple sclerosis 27.49 23.51 9 5288 1041 34950593
Gait spastic 27.11 23.51 9 5288 1087 34950547
Atrial fibrillation 26.83 23.51 58 5239 122335 34829299
Multiple organ dysfunction syndrome 26.35 23.51 44 5253 76522 34875112
Hypertonic bladder 25.96 23.51 10 5287 1854 34949780
Hyponatraemia 25.16 23.51 45 5252 82646 34868988
Constipation 24.59 23.51 60 5237 136922 34814712
General physical health deterioration 23.90 23.51 57 5240 128212 34823422
Memory impairment 23.75 23.51 31 5266 43287 34908347
Sleep disorder therapy 23.71 23.51 8 5289 1015 34950619

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Alopecia 127.80 13.07 267 28459 231088 79484574
Fatigue 121.76 13.07 656 28070 929071 78786591
Toxicity to various agents 107.23 13.07 13 28713 421527 79294135
Presbyacusis 81.25 13.07 32 28694 2628 79713034
Pleural thickening 77.70 13.07 32 28694 2950 79712712
Acute kidney injury 72.78 13.07 49 28677 519355 79196307
Blood magnesium increased 72.71 13.07 32 28694 3474 79712188
Appendicolith 68.24 13.07 41 28685 8510 79707152
Pleural fibrosis 67.42 13.07 32 28694 4135 79711527
Product dose omission issue 65.45 13.07 217 28509 247320 79468342
Stress 65.33 13.07 109 28617 79503 79636159
Completed suicide 61.41 13.07 8 28718 245759 79469903
Drug interaction 58.35 13.07 39 28687 415144 79300518
Headache 56.19 13.07 415 28311 653357 79062305
Deafness neurosensory 54.85 13.07 33 28693 6865 79708797
Cyst 54.66 13.07 43 28683 13797 79701865
Epigastric discomfort 53.22 13.07 34 28692 7862 79707800
COVID-19 50.68 13.07 148 28578 157526 79558136
Dry eye 48.32 13.07 63 28663 36868 79678794
Multiple sclerosis relapse 45.44 13.07 69 28657 46464 79669198
Osteopenia 42.27 13.07 42 28684 18322 79697340
Nausea 40.67 13.07 524 28202 956672 78758990
Blood phosphorus increased 40.54 13.07 32 28694 10315 79705347
Abdominal distension 40.07 13.07 114 28612 119536 79596126
Onychoclasis 40.05 13.07 25 28701 5553 79710109
Appendicitis 39.66 13.07 43 28683 20751 79694911
White blood cell count decreased 38.60 13.07 152 28574 188136 79527526
Dry mouth 37.77 13.07 92 28634 87927 79627735
Feeling abnormal 35.49 13.07 132 28594 159067 79556595
Memory impairment 34.10 13.07 103 28623 111631 79604031
C-reactive protein increased 32.70 13.07 4 28722 129023 79586639
Relapsing-remitting multiple sclerosis 31.94 13.07 14 28712 1505 79714157
Osteosclerosis 31.58 13.07 19 28707 3952 79711710
Blood uric acid increased 31.57 13.07 31 28695 13329 79702333
Injection site pain 30.92 13.07 110 28616 129728 79585934
Blood potassium increased 30.86 13.07 45 28681 29230 79686432
Sinusitis 30.24 13.07 145 28581 195356 79520306
Back pain 29.46 13.07 199 28527 303981 79411681
Burning sensation 29.22 13.07 65 28661 58567 79657095
Constipation 29.12 13.07 188 28538 282862 79432800
Bone cyst 28.80 13.07 17 28709 3416 79712246
Cardio-respiratory arrest 28.41 13.07 3 28723 108507 79607155
Urinary tract infection 28.03 13.07 182 28544 274330 79441332
Injection site erythema 27.64 13.07 76 28650 78121 79637541
Multiple sclerosis 27.58 13.07 37 28689 22245 79693417
Febrile neutropenia 27.02 13.07 26 28700 230973 79484689
Myasthenia gravis 26.21 13.07 25 28701 10374 79705288
Pancytopenia 25.44 13.07 14 28712 165731 79549931
Ventricular fibrillation 25.23 13.07 43 28683 31883 79683779
Dizziness 25.18 13.07 295 28431 526146 79189516
Intentional overdose 25.17 13.07 4 28722 105956 79609706
Somnolence 24.73 13.07 159 28567 238822 79476840
Muscle spasms 24.46 13.07 126 28600 174604 79541058
Overdose 23.63 13.07 19 28707 184187 79531475
Hyperphosphataemia 23.45 13.07 19 28707 6357 79709305
Osteoarthritis 22.54 13.07 76 28650 87233 79628429
Migraine 22.45 13.07 76 28650 87417 79628245
Confusional state 22.35 13.07 51 28675 317946 79397716
Depressed level of consciousness 22.18 13.07 4 28722 96648 79619014
Weight decreased 22.12 13.07 210 28516 354988 79360674
Iron deficiency 22.03 13.07 23 28703 10631 79705031
Drug therapy 21.84 13.07 10 28716 1191 79714471
Cardiac arrest 21.77 13.07 18 28708 172078 79543584
Illness 21.44 13.07 50 28676 46461 79669201
Dermatitis atopic 21.31 13.07 22 28704 10034 79705628
Needle fatigue 21.22 13.07 9 28717 893 79714769
Dry skin 21.04 13.07 63 28663 67932 79647730
Skin lesion 20.41 13.07 46 28680 41798 79673864
Balance disorder 20.40 13.07 80 28646 98777 79616885
Cardiogenic shock 20.36 13.07 46 28680 41868 79673794
Maternal exposure during pregnancy 20.28 13.07 12 28714 136526 79579136
Analgesic therapy 20.25 13.07 9 28717 1000 79714662
Pain in extremity 20.02 13.07 210 28516 364328 79351334
Gastrooesophageal reflux disease 19.63 13.07 82 28644 104164 79611498
Pruritus 19.22 13.07 222 28504 394426 79321236
Hypoaesthesia 18.96 13.07 120 28606 179232 79536430
Injection site swelling 18.88 13.07 48 28678 47084 79668578
Gait spastic 18.78 13.07 9 28717 1188 79714474
Neutropenia 18.75 13.07 48 28678 287662 79428000
Diarrhoea 18.57 13.07 431 28295 880058 78835604
Full blood count decreased 18.45 13.07 34 28692 26785 79688877
Hypokalaemia 18.30 13.07 15 28711 144025 79571637
Contraindicated product administered 18.11 13.07 18 28708 157520 79558142
Hot flush 18.08 13.07 52 28674 54825 79660837
Renal failure 17.83 13.07 28 28698 200940 79514722
Central nervous system lesion 17.79 13.07 23 28703 13345 79702317
Pyrexia 17.64 13.07 158 28568 678551 79037111
Thrombocytopenia 17.48 13.07 44 28682 265215 79450447
Vitamin B12 deficiency 17.48 13.07 17 28709 7224 79708438
Cardiac failure 17.45 13.07 18 28708 154824 79560838
Respiratory failure 17.22 13.07 24 28702 180887 79534775
Pain 17.21 13.07 352 28374 703450 79012212
Pre-existing condition improved 17.20 13.07 15 28711 5548 79710114
Sleep disorder therapy 16.98 13.07 8 28718 1016 79714646
Injection site pruritus 16.87 13.07 43 28683 42240 79673422
Sleep disorder 16.60 13.07 68 28658 85609 79630053
Interstitial lung disease 16.58 13.07 10 28716 112590 79603072
Neck pain 16.35 13.07 62 28664 75355 79640307
Spinal operation 16.20 13.07 17 28709 7900 79707762
Blood cholesterol increased 15.87 13.07 66 28660 83654 79632008
Injection site mass 15.70 13.07 27 28699 20157 79695505
Hyperkalaemia 15.70 13.07 11 28715 114387 79601275
Injection site bruising 15.64 13.07 41 28685 40961 79674701
Flatulence 15.57 13.07 42 28684 42682 79672980
Mucosal inflammation 15.56 13.07 4 28722 75576 79640086
Hypotension 15.51 13.07 94 28632 440223 79275439
Glossodynia 15.46 13.07 9 28717 103328 79612334
Rhabdomyolysis 15.41 13.07 9 28717 103122 79612540
Deformity 15.15 13.07 18 28708 9587 79706075
Anxiety 14.99 13.07 146 28580 248366 79467296
Arthralgia 14.97 13.07 289 28437 571514 79144148
Dysgeusia 14.96 13.07 50 28676 57127 79658535
Pollakiuria 14.94 13.07 38 28688 37279 79678383
Dyspepsia 14.94 13.07 78 28648 108609 79607053
Eructation 14.88 13.07 19 28707 10890 79704772
Delirium 14.74 13.07 6 28720 84621 79631041
Fall 14.71 13.07 252 28474 487377 79228285
Drug-induced liver injury 14.61 13.07 3 28723 66114 79649548
Lower respiratory tract infection 14.58 13.07 15 28711 129205 79586457
Bone hypertrophy 14.39 13.07 6 28720 571 79715091
Hypertonic bladder 14.36 13.07 12 28714 4189 79711473
Metabolic acidosis 14.14 13.07 6 28720 82523 79633139
Milk allergy 14.12 13.07 4 28722 117 79715545
Regurgitation 13.99 13.07 10 28716 2777 79712885
Angioedema 13.90 13.07 5 28721 76030 79639632
Surgery 13.78 13.07 34 28692 32732 79682930
Systemic lupus erythematosus 13.74 13.07 14 28712 121135 79594527
Limb discomfort 13.73 13.07 34 28692 32816 79682846
Electrocardiogram QT prolonged 13.34 13.07 8 28718 90378 79625284
Vision blurred 13.20 13.07 74 28652 105824 79609838

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA05 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:23354 coenzymes
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:26348 prosthetic groups
CHEBI has role CHEBI:50733 Dietary Supplement
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:78675 fundamental metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Biotin deficiency disease indication 49607006
Biotinidase deficiency off-label use 8808004 DOID:856
Propionic acidemia off-label use 69080001 DOID:14701
Holocarboxylase synthase deficiency off-label use 360369003 DOID:859
Constipation contraindication 14760008 DOID:2089
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Osteolysis contraindication 203522001




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.79 acidic
pKa2 13.37 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Insulin-degrading enzyme Enzyme EC50 5.60 CHEMBL

External reference:

IDSource
4017638 VUID
N0000146018 NUI
D00029 KEGG_DRUG
1588 RXNORM
C0005575 UMLSCUI
CHEBI:57586 CHEBI
BTN PDB_CHEM_ID
CHEMBL857 ChEMBL_ID
DB00121 DRUGBANK_ID
D001710 MESH_DESCRIPTOR_UI
171548 PUBCHEM_CID
4787 IUPHAR_LIGAND_ID
1203 INN_ID
6SO6U10H04 UNII
11819 MMSL
118935 MMSL
118941 MMSL
41034 MMSL
d06867 MMSL
13813003 SNOMEDCT_US
8919000 SNOMEDCT_US
4017638 VANDF
4020110 VANDF
001035 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 0.15 mg ORAL UNAPPROVED DRUG OTHER 15 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 100 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 100 ug ORAL UNAPPROVED DRUG OTHER 14 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 150 ug ORAL UNAPPROVED DRUG OTHER 10 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 300 ug ORAL Unapproved drug other 7 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 300 ug ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 300 ug ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 300 ug ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 300 ug ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 300 ug ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 300 ug ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 300 ug ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 300 ug ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 300 ug ORAL Unapproved drug other 7 sections
Quflora FE Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 14 15370-102 LIQUID 3 ug ORAL UNAPPROVED DRUG OTHER 11 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 17856-0010 TABLET, COATED 300 ug ORAL Unapproved drug other 8 sections
PNV-Select HUMAN PRESCRIPTION DRUG LABEL 18 42192-320 TABLET, FILM COATED 300 ug ORAL unapproved drug other 10 sections
PNV-Omega HUMAN PRESCRIPTION DRUG LABEL 13 42192-332 CAPSULE, GELATIN COATED 250 ug ORAL unapproved drug other 12 sections
HairQ-Plus HUMAN OTC DRUG LABEL 1 49658-2001 SHAMPOO 0.06 mL TOPICAL unapproved drug other 8 sections
HairQ-Plus HUMAN OTC DRUG LABEL 1 49658-4001 SOLUTION 0.06 mL TOPICAL unapproved drug other 8 sections
Bonogenhair care shampoo HUMAN OTC DRUG LABEL 4 50653-1001 SHAMPOO 0.06 g TOPICAL unapproved drug other 4 sections
Bonogen Plushair care shampoo HUMAN OTC DRUG LABEL 4 50653-2001 SHAMPOO 0.06 g TOPICAL unapproved drug other 4 sections
Bonogen Activatorhair loss treatment HUMAN OTC DRUG LABEL 1 50653-3001 LIQUID 0.00 mL TOPICAL unapproved drug other 6 sections
Born Hair HUMAN OTC DRUG LABEL 4 50653-4001 SHAMPOO 0.06 g TOPICAL unapproved drug other 7 sections
Doll Lash HUMAN OTC DRUG LABEL 4 51329-1001 LIQUID 0.06 mL TOPICAL unapproved drug other 8 sections
Concept OB HUMAN PRESCRIPTION DRUG LABEL 15 52747-620 CAPSULE 300 ug ORAL unapproved drug other 13 sections
Concept OB HUMAN PRESCRIPTION DRUG LABEL 15 52747-620 CAPSULE 300 ug ORAL unapproved drug other 13 sections
Concept DHA HUMAN PRESCRIPTION DRUG LABEL 15 52747-621 CAPSULE, LIQUID FILLED 300 ug ORAL unapproved drug other 7 sections
Concept DHA HUMAN PRESCRIPTION DRUG LABEL 15 52747-621 CAPSULE, LIQUID FILLED 300 ug ORAL unapproved drug other 7 sections
Integra Plus HUMAN PRESCRIPTION DRUG LABEL 10 52747-712 CAPSULE 300 ug ORAL unapproved drug other 12 sections