biotin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	373	58-85-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: biotin coenzyme R D-Biotin	A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. Molecular weight: 244.31 Formula: C10H16N2O3S CLOGP: -0.08 LIPINSKI: 0 HAC: 5 HDO: 3 TPSA: 78.43 ALOGS: -2.30 ROTB: 5 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

biotin
coenzyme R
D-Biotin

A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.

Molecular weight: 244.31
Formula: C10H16N2O3S
CLOGP: -0.08
LIPINSKI: 0
HAC: 5
HDO: 3
TPSA: 78.43
ALOGS: -2.30
ROTB: 5

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.22 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	43 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.01 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	99 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
Feb. 20, 1953	FDA	HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Fatigue	102.60	12.88	743	29240	787809	55474275
Toxicity to various agents	85.00	12.88	10	29973	224554	56037530
Pleural thickening	84.32	12.88	37	29946	2686	56259398
Blood magnesium increased	81.47	12.88	37	29946	2914	56259170
Presbyacusis	79.66	12.88	36	29947	2802	56259282
Pleural fibrosis	75.86	12.88	37	29946	3422	56258662
Synovitis	72.97	12.88	3	29980	161302	56100782
Alopecia	71.92	12.88	328	29655	293130	55968954
Deafness neurosensory	70.63	12.88	39	29944	4659	56257425
Product dose omission issue	65.95	12.88	249	29734	204504	56057580
Epigastric discomfort	62.81	12.88	40	29943	6208	56255876
Contraindicated product administered	62	12.88	12	29971	186274	56075810
Dry eye	59.85	12.88	84	29899	35632	56226452
Hand deformity	59.20	12.88	3	29980	134489	56127595
Cyst	58.55	12.88	51	29932	12727	56249357
Maternal exposure during pregnancy	57.49	12.88	15	29968	189538	56072546
Glossodynia	57.14	12.88	7	29976	152451	56109633
COVID-19	50.89	12.88	119	29864	74939	56187145
General physical health deterioration	50.52	12.88	14	29969	169996	56092088
Systemic lupus erythematosus	49.61	12.88	17	29966	180061	56082023
White blood cell count decreased	44.54	12.88	158	29825	125832	56136252
Diarrhoea	43.18	12.88	524	29459	637983	55624101
Rheumatoid arthritis	42.96	12.88	87	29896	382517	55879567
Headache	42.79	12.88	470	29513	558574	55703510
Onychoclasis	40.02	12.88	29	29954	5556	56256528
Muscle spasms	37.70	12.88	159	29824	137212	56124872
Back pain	37.39	12.88	235	29748	236935	56025149
Blood potassium increased	37.28	12.88	46	29937	17215	56244869
Osteopenia	37.04	12.88	47	29936	18094	56243990
Acute kidney injury	35.19	12.88	46	29937	240717	56021367
Drug interaction	35.05	12.88	36	29947	209719	56052365
Drug ineffective	31.85	12.88	325	29658	918664	55343420
Feeling abnormal	31.64	12.88	148	29835	133454	56128630
Bone cyst	30.31	12.88	17	29966	2093	56259991
Flatulence	28.57	12.88	56	29927	31232	56230852
Multiple sclerosis relapse	27.00	12.88	68	29915	44835	56217249
Sinusitis	26.43	12.88	188	29795	197393	56064691
Full blood count decreased	25.33	12.88	45	29938	23304	56238780
Skin lesion	25.25	12.88	50	29933	28085	56233999
Dizziness	24.57	12.88	307	29676	375833	55886251
C-reactive protein increased	24.27	12.88	6	29977	78678	56183406
Wound	24.12	12.88	23	29960	138781	56123303
Osteosclerosis	23.95	12.88	18	29965	3645	56258439
Hepatic enzyme increased	23.76	12.88	34	29949	171350	56090734
Memory impairment	23.58	12.88	100	29883	86457	56175627
Gastrooesophageal reflux disease	23.31	12.88	97	29886	83160	56178924
Pre-existing condition improved	23.31	12.88	24	29959	7374	56254710
Hot flush	23.28	12.88	66	29917	46660	56215424
Exposure during pregnancy	23.22	12.88	23	29960	136319	56125765
Constipation	22.99	12.88	185	29798	201758	56060326
Weight decreased	22.95	12.88	212	29771	240502	56021582
Lower respiratory tract infection	22.42	12.88	17	29966	114777	56147307
Urinary tract infection	21.52	12.88	209	29774	240304	56021780
Febrile neutropenia	21.43	12.88	15	29968	105530	56156554
Hyponatraemia	21.43	12.88	14	29969	102125	56159959
Osteoarthritis	21.28	12.88	92	29891	80204	56181880
Cardiac arrest	20.74	12.88	10	29973	86304	56175780
Illness	20.48	12.88	52	29931	34459	56227625
Nausea	20.27	12.88	541	29442	763637	55498447
Hypoaesthesia	19.71	12.88	136	29847	141355	56120729
Folliculitis	19.46	12.88	3	29980	54976	56207108
Injection site erythema	19.21	12.88	87	29896	77361	56184723
Migraine	18.98	12.88	94	29889	86703	56175381
Multiple sclerosis	18.74	12.88	44	29939	27758	56234326
Stress	18.38	12.88	71	29912	58839	56203245
Dry skin	18.30	12.88	61	29922	47048	56215036
Infusion site haemorrhage	17.44	12.88	15	29968	3680	56258404
Paraesthesia	17.33	12.88	124	29859	130390	56131694
Hypokalaemia	17.17	12.88	15	29968	94422	56167662
Burning sensation	17.13	12.88	61	29922	48635	56213449
Pain in extremity	16.99	12.88	237	29746	297194	55964890
Swelling	16.91	12.88	68	29915	239703	56022381
Dysgeusia	16.81	12.88	54	29929	40861	56221223
Overdose	16.73	12.88	19	29964	105811	56156273
Injection site pain	16.56	12.88	113	29870	117005	56145079
Increased tendency to bruise	16.38	12.88	23	29960	9755	56252329
Nail disorder	16.37	12.88	25	29958	11426	56250658
Product use issue	16.34	12.88	48	29935	185993	56076091
Surgery	16.29	12.88	46	29937	32440	56229644
Depressed level of consciousness	16.10	12.88	5	29978	56428	56205656
Flushing	16.10	12.88	77	29906	70023	56192061
Pruritus	16.00	12.88	247	29736	316376	55945708
Fall	15.88	12.88	273	29710	357237	55904847
Eosinophilic pleural effusion	15.84	12.88	4	29979	49	56262035
Drug intolerance	15.75	12.88	80	29903	264738	55997346
Gastrointestinal candidiasis	15.21	12.88	5	29978	163	56261921
Somnolence	15.09	12.88	143	29840	163270	56098814
Cardiac failure	14.97	12.88	13	29970	82080	56180004
Confusional state	14.70	12.88	59	29924	208096	56053988
Infusion related reaction	14.26	12.88	60	29923	208871	56053213
Death	14.23	12.88	115	29868	341311	55920773
Injection site mass	14.06	12.88	29	29954	16764	56245320
Bone hypertrophy	14.00	12.88	6	29977	411	56261673
Arthropathy	13.99	12.88	57	29926	200218	56061866
Exostosis	13.95	12.88	27	29956	14916	56247168
Infusion site erythema	13.77	12.88	21	29962	9585	56252499
Dry mouth	13.65	12.88	69	29914	64136	56197948
Limb discomfort	13.65	12.88	38	29945	26584	56235500
Vision blurred	13.54	12.88	83	29900	82860	56179224
Psoriasis	13.44	12.88	90	29893	92602	56169482
Balance disorder	13.41	12.88	78	29905	76442	56185642
Liver injury	13.28	12.88	3	29980	41845	56220239
Bradycardia	13.17	12.88	10	29973	67494	56194590
Retinal disorder	13.14	12.88	9	29974	1577	56260507
Sinus disorder	13.10	12.88	32	29951	20702	56241382
Infusion site pain	13.01	12.88	25	29958	13737	56248347
Foreign body in reproductive tract	12.93	12.88	6	29977	496	56261588
Gastrointestinal bacterial infection	12.91	12.88	7	29976	806	56261278
Pancytopenia	12.89	12.88	17	29966	88698	56173386

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Fractional exhaled nitric oxide increased	132.34	23.29	27	3701	605	31693011
Sensation of foreign body	99.20	23.29	27	3701	2144	31691472
Plantar fasciitis	97.27	23.29	25	3703	1590	31692026
Myoglobin blood increased	95.67	23.29	27	3701	2450	31691166
Secretion discharge	89.04	23.29	30	3698	4907	31688709
Brain natriuretic peptide increased	77.67	23.29	27	3701	4849	31688767
Dysphonia	55.74	23.29	33	3695	20558	31673058
Appendicolith	55.42	23.29	22	3706	5709	31687907
Dyspnoea exertional	53.72	23.29	41	3687	38796	31654820
Obstructive airways disorder	52.81	23.29	27	3701	12637	31680979
Exostosis	52.32	23.29	19	3709	3867	31689749
Appendicitis	40.83	23.29	22	3706	11443	31682173
Abdominal distension	40.36	23.29	39	3689	50645	31642971
Eosinophilia	37.64	23.29	27	3701	23226	31670390
Muscle spasms	37.33	23.29	43	3685	68275	31625341
Cardiac disorder	36.66	23.29	33	3695	39181	31654435
Nasopharyngitis	33.19	23.29	39	3689	63206	31630410
Ventricular fibrillation	33.08	23.29	23	3705	18825	31674791
Wheezing	33.08	23.29	30	3698	35956	31657660
Stress	31.57	23.29	25	3703	24916	31668700
Cardiogenic shock	29.52	23.29	23	3705	22385	31671231
Memory impairment	27.84	23.29	28	3700	38102	31655514
Chest discomfort	26.82	23.29	31	3697	49338	31644278
Coronary artery disease	25.13	23.29	29	3699	46058	31647558
Needle fatigue	23.69	23.29	7	3721	745	31692871

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Alopecia	151.12	13.66	261	25028	198229	70704926
Fatigue	121.10	13.66	596	24693	823723	70079432
Toxicity to various agents	100.46	13.66	10	25279	382162	70520993
Presbyacusis	81.84	13.66	32	25257	2605	70900550
Pleural thickening	79.62	13.66	32	25257	2800	70900355
Blood magnesium increased	74.61	13.66	32	25257	3299	70899856
Pleural fibrosis	67.95	13.66	32	25257	4107	70899048
Acute kidney injury	63.61	13.66	46	25243	474578	70428577
Product dose omission issue	62.65	13.66	195	25094	217273	70685882
Cyst	58.29	13.66	43	25246	12676	70890479
Deafness neurosensory	56.37	13.66	33	25256	6599	70896556
Epigastric discomfort	56.29	13.66	34	25255	7199	70895956
Headache	54.25	13.66	373	24916	580032	70323123
Drug interaction	52.35	13.66	36	25253	381405	70521750
Dry eye	48.98	13.66	59	25230	32223	70870932
Multiple sclerosis relapse	42.81	13.66	64	25225	42953	70860202
Osteopenia	40.28	13.66	39	25250	16658	70886497
Onychoclasis	40.26	13.66	24	25265	4960	70898195
Nausea	39.89	13.66	471	24818	851617	70051538
White blood cell count decreased	39.57	13.66	142	25147	169999	70733156
Stress	38.65	13.66	79	25210	67887	70835268
Feeling abnormal	37.65	13.66	124	25165	142195	70760960
COVID-19	37.29	13.66	102	25187	105655	70797500
Blood potassium increased	33.62	13.66	45	25244	27281	70875874
Appendicolith	32.51	13.66	22	25267	5658	70897497
Memory impairment	32.31	13.66	89	25200	92552	70810603
Bone cyst	31.78	13.66	17	25272	2857	70900298
Back pain	31.24	13.66	184	25105	270968	70632187
Burning sensation	30.70	13.66	62	25227	52808	70850347
Sinusitis	30.23	13.66	130	25159	169065	70734090
Urinary tract infection	29.43	13.66	170	25119	248599	70654556
Dizziness	28.37	13.66	271	25018	463870	70439285
Osteosclerosis	27.76	13.66	17	25272	3688	70899467
Abdominal distension	26.60	13.66	90	25199	104579	70798576
Injection site erythema	26.37	13.66	71	25218	72853	70830302
Injection site pain	26.34	13.66	97	25192	117522	70785633
C-reactive protein increased	26.28	13.66	4	25285	110513	70792642
Diarrhoea	26.26	13.66	408	24881	782933	70120222
Cardio-respiratory arrest	25.47	13.66	3	25286	100674	70802481
Osteoarthritis	24.64	13.66	70	25219	74077	70829078
Muscle spasms	24.24	13.66	114	25175	153932	70749223
Migraine	23.81	13.66	68	25221	72170	70830985
Skin lesion	23.41	13.66	46	25243	38414	70864741
Weight decreased	22.92	13.66	189	25100	310299	70592856
Multiple sclerosis	22.88	13.66	36	25253	25249	70877906
Illness	21.79	13.66	40	25249	31751	70871404
Dry skin	21.79	13.66	56	25233	55875	70847280
Constipation	21.58	13.66	159	25130	252279	70650876
Pain in extremity	21.24	13.66	194	25095	327888	70575267
Febrile neutropenia	21.16	13.66	25	25264	204293	70698862
Pancytopenia	21.04	13.66	14	25275	151093	70752062
Relapsing-remitting multiple sclerosis	20.66	13.66	10	25279	1363	70901792
Gastrooesophageal reflux disease	20.40	13.66	75	25214	90764	70812391
Cardiac failure	20.39	13.66	13	25276	143528	70759627
Dyspepsia	20.39	13.66	74	25215	89003	70814152
Overdose	19.54	13.66	19	25270	169726	70733429
Hypoaesthesia	19.44	13.66	107	25182	153632	70749523
Balance disorder	19.07	13.66	73	25216	90055	70813100
Depressed level of consciousness	18.97	13.66	4	25285	87427	70815728
Hot flush	18.65	13.66	49	25240	49535	70853620
Hypokalaemia	18.47	13.66	12	25277	131176	70771979
Cardiac arrest	18.27	13.66	18	25271	159816	70743339
Dry mouth	18.26	13.66	61	25228	70396	70832759
Arthralgia	17.89	13.66	265	25024	503125	70400030
Flatulence	17.83	13.66	41	25248	38140	70865015
Renal failure	17.65	13.66	25	25264	189045	70714110
Paraesthesia	17.54	13.66	100	25189	145437	70757718
Bone hypertrophy	16.96	13.66	6	25283	369	70902786
Injection site bruising	16.84	13.66	40	25249	37992	70865163
Confusional state	16.82	13.66	49	25240	284349	70618806
Dysgeusia	16.70	13.66	47	25242	49455	70853700
Pruritus	16.48	13.66	192	25097	345368	70557787
Injection site pruritus	16.04	13.66	40	25249	39170	70863985
Needle fatigue	16.01	13.66	7	25282	756	70902399
Neck pain	15.78	13.66	56	25233	66601	70836554
Nail disorder	15.72	13.66	19	25270	10405	70892750
Deformity	15.69	13.66	17	25272	8280	70894875
Maternal exposure during pregnancy	15.64	13.66	11	25278	115334	70787821
Interstitial lung disease	15.54	13.66	9	25280	104676	70798479
Neutropenia	15.43	13.66	44	25245	257112	70646043
Appendicitis	15.38	13.66	24	25265	16709	70886446
Anxiety	15.12	13.66	132	25157	220198	70682957
Pyrexia	15.12	13.66	141	25148	606811	70296344
Limb discomfort	15.11	13.66	33	25256	29672	70873483
Respiratory failure	15.07	13.66	23	25266	168712	70734443
Fall	15.07	13.66	232	25057	443864	70459291
Injection site mass	15.07	13.66	25	25264	18318	70884837
Full blood count decreased	15.03	13.66	29	25260	23889	70879266
Thrombocytopenia	15.02	13.66	40	25249	239070	70664085
Metabolic acidosis	14.95	13.66	4	25285	74342	70828813
Injection site swelling	14.58	13.66	41	25248	43116	70860039
Central nervous system lesion	14.55	13.66	20	25269	12433	70890722
Vitamin B12 deficiency	14.50	13.66	14	25275	5958	70897197
Dysphonia	14.46	13.66	45	25244	50055	70853100
Spinal operation	14.35	13.66	15	25274	7013	70896142
Milk allergy	14.33	13.66	4	25285	112	70903043
Insomnia	14.18	13.66	129	25160	217677	70685478
Vision blurred	14.00	13.66	69	25220	94915	70808240
Gait spastic	13.89	13.66	7	25282	1040	70902115
Flushing	13.80	13.66	62	25227	82110	70821045
Exostosis	13.78	13.66	21	25268	14324	70888831

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A11HA05	ALIMENTARY TRACT AND METABOLISM VITAMINS OTHER PLAIN VITAMIN PREPARATIONS Other plain vitamin preparations
MeSH PA	D018977	Micronutrients
MeSH PA	D014803	Vitamin B Complex
MeSH PA	D014815	Vitamins
CHEBI has role	CHEBI:23354	coenzymes
CHEBI has role	CHEBI:23357	cofactor
CHEBI has role	CHEBI:26348	prosthetic groups
CHEBI has role	CHEBI:50733	Dietary Supplement
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:75772	S. cerevisiae metabolites
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:78675	fundamental metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Biotin deficiency disease	indication	49607006
Biotinidase deficiency	off-label use	8808004	DOID:856
Propionic acidemia	off-label use	69080001	DOID:14701
Holocarboxylase synthase deficiency	off-label use	360369003	DOID:859
Constipation	contraindication	14760008	DOID:2089
Sarcoidosis	contraindication	31541009	DOID:11335
Dehydration	contraindication	34095006
Hypercalcemia	contraindication	66931009	DOID:12678
Hyperparathyroidism	contraindication	66999008	DOID:13543
Kidney disease	contraindication	90708001	DOID:557
Kidney stone	contraindication	95570007
Osteolysis	contraindication	203522001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.79	acidic
pKa2	13.37	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Insulin-degrading enzyme	Enzyme	P14735	IDE_HUMAN		EC50	5.60		CHEMBL

External reference:

ID	Source
4017638	VUID
N0000146018	NUI
D00029	KEGG_DRUG
1588	RXNORM
4017638	VANDF
4020110	VANDF
C0005575	UMLSCUI
CHEBI:57586	CHEBI
BTN	PDB_CHEM_ID
CHEMBL857	ChEMBL_ID
DB00121	DRUGBANK_ID
D001710	MESH_DESCRIPTOR_UI
171548	PUBCHEM_CID
4787	IUPHAR_LIGAND_ID
1203	INN_ID
6SO6U10H04	UNII
11819	MMSL
118935	MMSL
118941	MMSL
d06867	MMSL
001035	NDDF
13813003	SNOMEDCT_US
8919000	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Strovite Forte Caplet	HUMAN PRESCRIPTION DRUG LABEL	19	0642-0204	TABLET, COATED	0.15 mg	ORAL	UNAPPROVED DRUG OTHER	15 sections
Strovite One Caplets	HUMAN PRESCRIPTION DRUG LABEL	20	0642-0207	TABLET	100 ug	ORAL	UNAPPROVED DRUG OTHER	14 sections
BACMIN	HUMAN PRESCRIPTION DRUG LABEL	19	0682-3001	TABLET, COATED	150 ug	ORAL	UNAPPROVED DRUG OTHER	10 sections
Dialyvite Supreme D	HUMAN PRESCRIPTION DRUG LABEL	13	10542-009	TABLET, COATED	300 ug	ORAL	Unapproved drug other	7 sections
Dialyvite Supreme D	HUMAN PRESCRIPTION DRUG LABEL	13	10542-009	TABLET, COATED	300 ug	ORAL	Unapproved drug other	7 sections
Dialyvite	HUMAN PRESCRIPTION DRUG LABEL	9	10542-010	TABLET, COATED	300 ug	ORAL	Unapproved drug other	7 sections
Dialyvite	HUMAN PRESCRIPTION DRUG LABEL	9	10542-010	TABLET, COATED	300 ug	ORAL	Unapproved drug other	7 sections
Dialyvite 5000	HUMAN PRESCRIPTION DRUG LABEL	12	10542-011	TABLET, COATED	300 ug	ORAL	Unapproved drug other	7 sections
Dialyvite 5000	HUMAN PRESCRIPTION DRUG LABEL	12	10542-011	TABLET, COATED	300 ug	ORAL	Unapproved drug other	7 sections
Dialyvite with Zinc	HUMAN PRESCRIPTION DRUG LABEL	10	10542-012	TABLET, COATED	300 ug	ORAL	Unapproved drug other	7 sections
Dialyvite with Zinc	HUMAN PRESCRIPTION DRUG LABEL	10	10542-012	TABLET, COATED	300 ug	ORAL	Unapproved drug other	7 sections
Dialyvite 3000	HUMAN PRESCRIPTION DRUG LABEL	12	10542-014	TABLET, COATED	300 ug	ORAL	Unapproved drug other	7 sections
Dialyvite 3000	HUMAN PRESCRIPTION DRUG LABEL	12	10542-014	TABLET, COATED	300 ug	ORAL	Unapproved drug other	7 sections
Quflora FE Pediatric Drops	HUMAN PRESCRIPTION DRUG LABEL	14	15370-102	LIQUID	3 ug	ORAL	UNAPPROVED DRUG OTHER	11 sections
Dialyvite	HUMAN PRESCRIPTION DRUG LABEL	9	17856-0010	TABLET, COATED	300 ug	ORAL	Unapproved drug other	8 sections
PNV-Select	HUMAN PRESCRIPTION DRUG LABEL	18	42192-320	TABLET, FILM COATED	300 ug	ORAL	unapproved drug other	10 sections
PNV-Omega	HUMAN PRESCRIPTION DRUG LABEL	13	42192-332	CAPSULE, GELATIN COATED	250 ug	ORAL	unapproved drug other	12 sections
HairQ-Plus	HUMAN OTC DRUG LABEL	1	49658-2001	SHAMPOO	0.06 mL	TOPICAL	unapproved drug other	8 sections
HairQ-Plus	HUMAN OTC DRUG LABEL	1	49658-4001	SOLUTION	0.06 mL	TOPICAL	unapproved drug other	8 sections
Bonogenhair care shampoo	HUMAN OTC DRUG LABEL	4	50653-1001	SHAMPOO	0.06 g	TOPICAL	unapproved drug other	2 sections
Bonogen Plushair care shampoo	HUMAN OTC DRUG LABEL	4	50653-2001	SHAMPOO	0.06 g	TOPICAL	unapproved drug other	2 sections
Bonogen Activatorhair loss treatment	HUMAN OTC DRUG LABEL	1	50653-3001	LIQUID	0.00 mL	TOPICAL	unapproved drug other	3 sections
Born Hair	HUMAN OTC DRUG LABEL	4	50653-4001	SHAMPOO	0.06 g	TOPICAL	unapproved drug other	7 sections
Doll Lash	HUMAN OTC DRUG LABEL	4	51329-1001	LIQUID	0.06 mL	TOPICAL	unapproved drug other	8 sections
Concept OB	HUMAN PRESCRIPTION DRUG LABEL	15	52747-620	CAPSULE	300 ug	ORAL	unapproved drug other	13 sections
Concept OB	HUMAN PRESCRIPTION DRUG LABEL	15	52747-620	CAPSULE	300 ug	ORAL	unapproved drug other	13 sections
Concept DHA	HUMAN PRESCRIPTION DRUG LABEL	15	52747-621	CAPSULE, LIQUID FILLED	300 ug	ORAL	unapproved drug other	7 sections
Concept DHA	HUMAN PRESCRIPTION DRUG LABEL	15	52747-621	CAPSULE, LIQUID FILLED	300 ug	ORAL	unapproved drug other	7 sections
Integra Plus	HUMAN PRESCRIPTION DRUG LABEL	10	52747-712	CAPSULE	300 ug	ORAL	unapproved drug other	12 sections
Integra Plus	HUMAN PRESCRIPTION DRUG LABEL	10	52747-712	CAPSULE	300 ug	ORAL	unapproved drug other	12 sections