biotin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
373 58-85-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • biotin
  • coenzyme R
  • D-Biotin
A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.
  • Molecular weight: 244.31
  • Formula: C10H16N2O3S
  • CLOGP: -0.08
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 78.43
  • ALOGS: -2.30
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.22 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 43 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.01 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA05 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
CHEBI has role CHEBI:75769 B vitamin
CHEBI has role CHEBI:50733 nutraceutical
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Biotin deficiency disease indication 49607006
Biotinidase deficiency off-label use 8808004 DOID:856
Propionic acidemia off-label use 69080001 DOID:14701
Holocarboxylase synthase deficiency off-label use 360369003 DOID:859
Constipation contraindication 14760008 DOID:2089
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Osteolysis contraindication 203522001

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.79 acidic
pKa2 13.37 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Insulin-degrading enzyme Enzyme EC50 5.60 CHEMBL

External reference:

IDSource
D001710 MESH_DESCRIPTOR_UI
4017638 VUID
N0000146018 NUI
C0005575 UMLSCUI
D00029 KEGG_DRUG
6SO6U10H04 UNII
1203 INN_ID
13813003 SNOMEDCT_US
8919000 SNOMEDCT_US
4017638 VANDF
118935 MMSL
11819 MMSL
d06867 MMSL
001035 NDDF
1588 RXNORM
171548 PUBCHEM_CID
CHEBI:15956 CHEBI
CHEMBL857 ChEMBL_ID
DB00121 DRUGBANK_ID
BTN PDB_CHEM_ID
4787 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Strovite Forte HUMAN PRESCRIPTION DRUG LABEL 11 0642-0204 TABLET, COATED 0.15 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Strovite One HUMAN PRESCRIPTION DRUG LABEL 17 0642-0207 TABLET 100 ug ORAL UNAPPROVED DRUG OTHER 10 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 15 0682-3001 TABLET, COATED 150 ug ORAL UNAPPROVED DRUG OTHER 9 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 10 10542-009 TABLET, COATED 300 ug ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 8 10542-010 TABLET, COATED 300 ug ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 9 10542-011 TABLET, COATED 300 ug ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 8 10542-012 TABLET, COATED 300 ug ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 9 10542-014 TABLET, COATED 300 ug ORAL Unapproved drug other 7 sections
Quflora FE Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 12 15370-102 LIQUID 3 ug ORAL UNAPPROVED DRUG OTHER 8 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 8 17856-0010 TABLET, COATED 300 ug ORAL Unapproved drug other 8 sections
PNV-Select HUMAN PRESCRIPTION DRUG LABEL 17 42192-320 TABLET, FILM COATED 300 ug ORAL unapproved drug other 11 sections
PNV-Omega HUMAN PRESCRIPTION DRUG LABEL 13 42192-332 CAPSULE, GELATIN COATED 250 ug ORAL unapproved drug other 9 sections
HairQ-Plus HUMAN OTC DRUG LABEL 1 49658-2001 SHAMPOO 0.06 mL TOPICAL unapproved drug other 7 sections
HairQ-Plus HUMAN OTC DRUG LABEL 1 49658-4001 SOLUTION 0.06 mL TOPICAL unapproved drug other 7 sections
Bonogen HUMAN OTC DRUG LABEL 3 50653-1001 SHAMPOO 0.06 g TOPICAL unapproved drug other 1 sections
Bonogen Plus HUMAN OTC DRUG LABEL 3 50653-2001 SHAMPOO 0.06 g TOPICAL unapproved drug other 1 sections
Bonogen Activator HUMAN OTC DRUG LABEL 1 50653-3001 LIQUID 0.00 mL TOPICAL unapproved drug other 1 sections
Born Hair HUMAN OTC DRUG LABEL 3 50653-4001 SHAMPOO 0.06 g TOPICAL unapproved drug other 7 sections
IROSPAN 24/6 HUMAN PRESCRIPTION DRUG LABEL 20 50967-126 KIT 300 ug None unapproved drug other 9 sections
IROSPAN 24/6 HUMAN PRESCRIPTION DRUG LABEL 20 50967-126 KIT 300 ug None unapproved drug other 9 sections
Doll Lash HUMAN OTC DRUG LABEL 3 51329-1001 LIQUID 0.06 mL TOPICAL unapproved drug other 7 sections
Concept OB HUMAN PRESCRIPTION DRUG LABEL 15 52747-620 CAPSULE 300 ug ORAL unapproved drug other 1 sections
Concept DHA HUMAN PRESCRIPTION DRUG LABEL 14 52747-621 CAPSULE, LIQUID FILLED 300 ug ORAL unapproved drug other 1 sections
Integra Plus HUMAN PRESCRIPTION DRUG LABEL 9 52747-712 CAPSULE 300 ug ORAL unapproved drug other 2 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 15 52796-173 TABLET, CHEWABLE 40 ug ORAL UNAPPROVED DRUG OTHER 6 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 15 52796-174 TABLET, CHEWABLE 40 ug ORAL UNAPPROVED DRUG OTHER 6 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 15 52796-177 TABLET, CHEWABLE 40 ug ORAL UNAPPROVED DRUG OTHER 7 sections
PEDIATRIC INFUVITE MULTIPLE VITAMINS FOR INFUSION HUMAN PRESCRIPTION DRUG LABEL 12 54643-5646 INJECTION, SOLUTION 20 ug INTRAVENOUS NDA 14 sections
Pediatric Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 12 54643-5647 KIT 20 ug None NDA 14 sections
Adult Infuvite Multiple Vitamins for Infusion HUMAN PRESCRIPTION DRUG LABEL 13 54643-5649 INJECTION, SOLUTION 60 ug INTRAVENOUS NDA 11 sections