betacarotene 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
arotinoid derivatives	345	7235-40-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: betacarotene provatene beta-Carotene beta carotene	A carotenoid that is a precursor of VITAMIN A. Beta carotene is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). Molecular weight: 536.89 Formula: C40H56 CLOGP: 12 LIPINSKI: 2 HAC: 0 HDO: 0 TPSA: ALOGS: -6.14 ROTB: 10 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

betacarotene
provatene
beta-Carotene
beta carotene

A carotenoid that is a precursor of VITAMIN A. Beta carotene is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC).

Molecular weight: 536.89
Formula: C40H56
CLOGP: 12
LIPINSKI: 2
HAC: 0
HDO: 0
TPSA:
ALOGS: -6.14
ROTB: 10

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.10	g	O

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	25 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	268.34	113.66	66	1670	8535	34946660
Appendicitis	232.79	113.66	66	1670	14741	34940454
Ventricular fibrillation	204.24	113.66	66	1670	22888	34932307
Cardiogenic shock	198.60	113.66	67	1669	26551	34928644
Stress	189.99	113.66	67	1669	30280	34924915
Blood phosphorus increased	170.40	113.66	45	1691	7676	34947519
Ascites	158.68	113.66	66	1670	46505	34908690
Hyponatraemia	148.45	113.66	75	1661	82616	34872579
Abdominal distension	144.21	113.66	66	1670	58426	34896769
Multiple organ dysfunction syndrome	130.20	113.66	67	1669	76499	34878696

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	312.28	54.98	66	1969	8485	79733868
Appendicitis	253.94	54.98	66	1969	20728	79721625
Ventricular fibrillation	225.91	54.98	66	1969	31860	79710493
Cardiogenic shock	212.36	54.98	67	1968	41847	79700506
Stress	188.13	54.98	72	1963	79540	79662813
Blood phosphorus increased	186.98	54.98	45	1990	10302	79732051
Ascites	170.13	54.98	66	1969	75496	79666857
Multiple organ dysfunction syndrome	146.80	54.98	68	1967	120178	79622175
Hyponatraemia	141.14	54.98	75	1960	177773	79564580
Abdominal distension	140.88	54.98	66	1969	119584	79622769

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	A11CA02	ALIMENTARY TRACT AND METABOLISM VITAMINS VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO Vitamin A, plain
ATC	D02BB01	DERMATOLOGICALS EMOLLIENTS AND PROTECTIVES PROTECTIVES AGAINST UV-RADIATION Protectives against UV-radiation for systemic use
CHEBI has role	CHEBI:22586	antioxidants
CHEBI has role	CHEBI:23357	cofactor
CHEBI has role	CHEBI:26130	pigments
CHEBI has role	CHEBI:67200	provitamin As
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:173084	ferroptosis inhibitors

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Primary hyperoxaluria	contraindication	17901006	DOID:2977
Blood coagulation disorder	contraindication	64779008	DOID:1247
Wilson's disease	contraindication	88518009
Anemia due to enzyme deficiency	contraindication	111577008
Hb SS disease	contraindication	127040003	DOID:10923
Hemochromatosis	contraindication	399187006	DOID:2352
Vitamin K Deficiency Induced Hypoprothrombinemia	contraindication

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Core protein	Unclassified		Q2Q167_9HEPC		IC50	4.53		CHEMBL

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External reference:

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ID	Source
BCR	PDB_CHEM_ID
001003	NDDF
002022	NDDF
01YAE03M7J	UNII
103068006	SNOMEDCT_US
19143	RXNORM
329507006	SNOMEDCT_US
4017793	VANDF
4020599	VUID
4020599	VANDF

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Active FE	HUMAN PRESCRIPTION DRUG LABEL	14	58809-725	TABLET	2100 [iU]	ORAL	UNAPPROVED DRUG OTHER	17 sections
Floriva	HUMAN PRESCRIPTION DRUG LABEL	16	52796-173	TABLET, CHEWABLE	1000 [iU]	ORAL	UNAPPROVED DRUG OTHER	6 sections
Floriva	HUMAN PRESCRIPTION DRUG LABEL	16	52796-174	TABLET, CHEWABLE	1000 [iU]	ORAL	UNAPPROVED DRUG OTHER	6 sections
Floriva	HUMAN PRESCRIPTION DRUG LABEL	16	52796-177	TABLET, CHEWABLE	1000 [iU]	ORAL	UNAPPROVED DRUG OTHER	7 sections
healthy mamaBE WELL ROUNDED BE WELL ROUNDED	HUMAN PRESCRIPTION DRUG LABEL	17	58154-107	TABLET, FILM COATED	4000 [iU]	ORAL	unapproved drug other	8 sections
NataChew	HUMAN PRESCRIPTION DRUG LABEL	11	44118-902	TABLET, CHEWABLE	2700 [iU]	ORAL	unapproved drug other	7 sections
PNV Prenatal Plus Multivitamin	HUMAN PRESCRIPTION DRUG LABEL	15	50090-0617	TABLET	2000 [iU]	ORAL	Unapproved drug other	9 sections
PNV Prenatal Plus Multivitamin	HUMAN PRESCRIPTION DRUG LABEL	15	63629-6973	TABLET	2000 [iU]	ORAL	Unapproved drug other	9 sections
PRENATAL PLUS	HUMAN PRESCRIPTION DRUG LABEL	15	10544-549	TABLET, FILM COATED	920 [iU]	ORAL	unapproved drug other	8 sections
PRENATAL PLUS	HUMAN PRESCRIPTION DRUG LABEL	15	15338-522	TABLET, FILM COATED	920 [iU]	ORAL	unapproved drug other	8 sections

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