nimustine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antineoplastic, alkylating agents, (beta-chloroethyl)amine derivatives 3384 42471-28-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nimustine
  • nimustine hydrochloride
  • nimustine HCl
Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.
  • Molecular weight: 272.69
  • Formula: C9H13ClN6O2
  • CLOGP: 0.48
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 2
  • TPSA: 113.57
  • ALOGS: -3.26
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,CDK5,CDK9,EIF2AK3,GRK2,MAPK7,PDK1,PDK2,PRKDC 10
kinase-selectivity-class GRK2 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01AD06 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ALKYLATING AGENTS
Nitrosoureas
MeSH PA D000970 Antineoplastic Agents
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:22333 alkylating agent

Related Drugs by ATC class:

L01AD Nitrosoureas 7 drugs
carmustinefotemustinelomustineranimustinesemustinestreptozocinuracil mustard

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.33 acidic
pKa2 6.61 Basic
pKa3 0.21 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01059 KEGG_DRUG
C0028096 UMLSCUI
CHEBI:75270 CHEBI
CHEMBL136737 ChEMBL_ID
DB13069 DRUGBANK_ID
CHEMBL1256616 ChEMBL_ID
D015376 MESH_DESCRIPTOR_UI
39214 PUBCHEM_CID
4258 INN_ID
55661-38-6 SECONDARY_CAS_RN
0S726V972K UNII
006595 NDDF
006596 NDDF

Pharmaceutical products:

None