nimustine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antineoplastic, alkylating agents, (beta-chloroethyl)amine derivatives | 3384 | 42471-28-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L01AD06 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS ALKYLATING AGENTS Nitrosoureas |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| MeSH PA | D000970 | Antineoplastic Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.33 | acidic |
| pKa2 | 6.61 | Basic |
| pKa3 | 0.21 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D01059 | KEGG_DRUG |
| 55661-38-6 | SECONDARY_CAS_RN |
| C0028096 | UMLSCUI |
| CHEBI:75270 | CHEBI |
| CHEMBL136737 | ChEMBL_ID |
| DB13069 | DRUGBANK_ID |
| D015376 | MESH_DESCRIPTOR_UI |
| 39214 | PUBCHEM_CID |
| 4258 | INN_ID |
| 0S726V972K | UNII |
| 006595 | NDDF |
| 006596 | NDDF |
| CHEMBL1256616 | ChEMBL_ID |
Pharmaceutical products:
None