fotemustine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastic, alkylating agents, (beta-chloroethyl)amine derivatives 1249 92118-27-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fotemustine
  • muphoran
  • mustophorane
  • Molecular weight: 315.69
  • Formula: C9H19ClN3O5P
  • CLOGP: 0.97
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 1
  • TPSA: 97.30
  • ALOGS: -1.89
  • ROTB: 9

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.62 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 18.50 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.38 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01AD05 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ALKYLATING AGENTS
Nitrosoureas
MeSH PA D000970 Antineoplastic Agents
CHEBI has role CHEBI:35610 cytostatic

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07255 KEGG_DRUG
C0060696 UMLSCUI
CHEBI:131848 CHEBI
CHEMBL549386 ChEMBL_ID
DB04106 DRUGBANK_ID
C054368 MESH_SUPPLEMENTAL_RECORD_UI
104799 PUBCHEM_CID
5982 INN_ID
GQ7JL9P5I2 UNII
005271 NDDF
697996006 SNOMEDCT_US

Pharmaceutical products:

None