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streptozocin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2483 | 18883-66-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 407.20 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 21 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAP3K21,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PRKDC,TEK | 20 | |||
| kinase-selectivity-class | AXL,CDK2,CDK4,CDK9,CHUK,GRK2,MAP2K6,MAP3K14,PIK3CD,TGFBR1,ZAP70 | 11 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| May 7, 1982 | FDA | TEVA PHARMS USA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Nephropathy toxic | 92.99 | 57.95 | 17 | 180 | 12671 | 90615579 |
| Chronic kidney disease | 64.58 | 57.95 | 16 | 181 | 50175 | 90578075 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Nephropathy toxic | 62.78 | 51.00 | 17 | 624 | 27461 | 110561197 |
| Malignant neoplasm progression | 56.65 | 51.00 | 25 | 616 | 174542 | 110414116 |
| Chronic kidney disease | 53.16 | 51.00 | 19 | 622 | 76272 | 110512386 |
| Left ventricular dysfunction | 51.15 | 51.00 | 14 | 627 | 23479 | 110565179 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L01AD04 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS ALKYLATING AGENTS Nitrosoureas |
| FDA MoA | N0000000236 | Alkylating Activity |
| FDA EPC | N0000175558 | Alkylating Drug |
| MeSH PA | D000903 | Antibiotics, Antineoplastic |
| MeSH PA | D000970 | Antineoplastic Agents |
| CHEBI has role | CHEBI:25212 | metabolite |
| CHEBI has role | CHEBI:33281 | antimicrobial agent |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:59517 | DNA synthesis inhibitor |
Related Drugs by ATC class:
L01AD Nitrosoureas 7 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Pancreatic Neuroendocrine Tumor | indication | 717919005 | |
| Carcinoid syndrome | off-label use | 35868009 | |
| Mycosis | contraindication | 3218000 | DOID:1564 |
| Viral disease | contraindication | 34014006 | DOID:934 |
| Dehydration | contraindication | 34095006 | |
| Infectious disease | contraindication | 40733004 | |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Leukopenia | contraindication | 84828003 | DOID:615 |
| Bacterial infectious disease | contraindication | 87628006 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Anemia | contraindication | 271737000 | DOID:2355 |
| Pregnancy, function | contraindication | 289908002 | |
| Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
| Bone marrow depression | contraindication | 307762000 | |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Protozoal Infection | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.1 | acidic |
| pKa2 | 12.56 | acidic |
| pKa3 | 13.33 | acidic |
| pKa4 | 13.57 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4018094 | VUID |
| N0000146432 | NUI |
| D05932 | KEGG_DRUG |
| 4018094 | VANDF |
| C0038432 | UMLSCUI |
| CHEBI:9288 | CHEBI |
| STZ | PDB_CHEM_ID |
| CHEMBL1977579 | ChEMBL_ID |
| DB00428 | DRUGBANK_ID |
| D013311 | MESH_DESCRIPTOR_UI |
| 29327 | PUBCHEM_CID |
| 3824 | INN_ID |
| 5W494URQ81 | UNII |
| 10114 | RXNORM |
| 1423 | MMSL |
| 5515 | MMSL |
| d00375 | MMSL |
| 002663 | NDDF |
| 16915004 | SNOMEDCT_US |
| 404876000 | SNOMEDCT_US |
| 5W494URQ81 | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Zanosar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68118-100 | POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | Unapproved drug for use in drug shortage | 3 sections |
| Zanosar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68118-500 | POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | Unapproved drug for use in drug shortage | 3 sections |