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enoxolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids not used as glucocorticosteroids | 3178 | 471-53-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 3.219 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.518 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 70.958 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 18.450 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 1.300 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 3.180 | % | High | 1 |
| herg | hERG pIC50 | 4.820 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 3.673 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 8.511 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 1.370 | % | High | 1 |
| kinase-safety-class | ACVR2B,CDK5,EIF2AK3,GRK2,ITK,PDK1,PDK2,PRKDC | 8 | |||
| kinase-selectivity-class | EIF2AK3,GRK2 | 2 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 2.339 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 16.144 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 2.070 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 11.614 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 0.720 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 12.853 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 20.520 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 1.820 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 244.343 | uM | High | 1 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D03AX10 | DERMATOLOGICALS PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS CICATRIZANTS Other cicatrizants |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| CHEBI has role | CHEBI:35469 | antidepressant |
| CHEBI has role | CHEBI:49201 | anti-ulcer drug |
| CHEBI has role | CHEBI:50846 | immunomodulator |
| CHEBI has role | CHEBI:76924 | plant metabolite |
Related Drugs by ATC class:
D03AX Other cicatrizants 9 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.89 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Protein-tyrosine phosphatase 1C | Enzyme | IC50 | 4.18 | CHEMBL | |||||
| Arachidonate 5-lipoxygenase | Enzyme | IC50 | 4.61 | CHEMBL | |||||
| Tyrosine-protein phosphatase non-receptor type 1 | Enzyme | IC50 | 4.34 | CHEMBL | |||||
| Liver carboxylesterase 1 | Enzyme | IC50 | 4.68 | CHEMBL | |||||
| Protein kinase C eta type | Kinase | Kd | 6.60 | CHEMBL | |||||
| Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | IC50 | 8.91 | CHEMBL | |||||
| Corticosteroid 11-beta-dehydrogenase isozyme 1 | Enzyme | IC50 | 8.07 | CHEMBL | |||||
| Cocaine esterase | Enzyme | IC50 | 4.16 | CHEMBL | |||||
| Aldo-keto reductase family 1 member B10 | Enzyme | IC50 | 5.31 | CHEMBL | |||||
| Tyrosine-protein phosphatase non-receptor type 11 | Enzyme | IC50 | 5.02 | CHEMBL | |||||
| High mobility group protein B1 | Nuclear other | Kd | 4.06 | CHEMBL | |||||
| Corticosteroid 11-beta-dehydrogenase isozyme 1 | Enzyme | IC50 | 8.70 | CHEMBL | |||||
| Glycogen phosphorylase, muscle form | Enzyme | IC50 | 4.18 | CHEMBL | |||||
| Beta-glucuronidase | Enzyme | IC50 | 4.01 | CHEMBL | |||||
| Corticosteroid 11-beta-dehydrogenase isozyme 1 | Enzyme | IC50 | 7.05 | CHEMBL | |||||
| Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | IC50 | 6.44 | CHEMBL | |||||
| Lactoylglutathione lyase | Enzyme | Ki | 6.54 | CHEMBL | |||||
| Beta-glucuronidase | Enzyme | IC50 | 4.92 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000166340 | NUI |
| D00156 | KEGG_DRUG |
| C0017986 | UMLSCUI |
| CHEBI:30853 | CHEBI |
| CHEMBL230006 | ChEMBL_ID |
| DB13089 | DRUGBANK_ID |
| 11264 | IUPHAR_LIGAND_ID |
| 1794 | INN_ID |
| P540XA09DR | UNII |
| 10114 | PUBCHEM_CID |
| 1311506 | RXNORM |
| 005620 | NDDF |
| 414356009 | SNOMEDCT_US |
| 414357000 | SNOMEDCT_US |
| D006034 | MESH_DESCRIPTOR_UI |
| CBW | PDB_CHEM_ID |
| P540XA09DR | INXIGHT DRUGS |
Pharmaceutical products:
None