Stem definition | Drug id | CAS RN |
---|---|---|
antipsychotics, haloperidol derivatives | 312 | 2062-84-2 |
Dose | Unit | Route |
---|---|---|
1.50 | mg | O |
Property | Value | Reference |
---|---|---|
MRTD (Maximum Recommended Therapeutic Daily Dose) | 1.50 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 40 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 3.80 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 8.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 5.80 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 1, 1965 | YEAR INTRODUCED |
None
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuroleptic malignant syndrome | 119.84 | 99.30 | 30 | 577 | 27529 | 79716252 |
None
Source | Code | Description |
---|---|---|
ATC | N05AD07 | NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Butyrophenone derivatives |
MeSH PA | D014150 | Antipsychotic Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D015259 | Dopamine Agents |
MeSH PA | D018492 | Dopamine Antagonists |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D014149 | Tranquilizing Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Antisocial behavior | indication | 60814007 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.93 | acidic |
pKa2 | 8.12 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor | GPCR | Ki | 10.57 | WOMBAT-PK | |||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | EC50 | 5.94 | WOMBAT-PK | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 8.47 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 9 | WOMBAT-PK | |||||
D(3) dopamine receptor | GPCR | Ki | 10.18 | WOMBAT-PK | |||||
D(4) dopamine receptor | GPCR | Ki | 8.70 | WOMBAT-PK |
ID | Source |
---|---|
N0000166794 | NUI |
D02627 | KEGG_DRUG |
1373 | RXNORM |
C0005013 | UMLSCUI |
CHEBI:93403 | CHEBI |
CHEMBL297302 | ChEMBL_ID |
DB12867 | DRUGBANK_ID |
D001544 | MESH_DESCRIPTOR_UI |
16363 | PUBCHEM_CID |
9215 | IUPHAR_LIGAND_ID |
1577 | INN_ID |
97O6X78C53 | UNII |
321391002 | SNOMEDCT_US |
391820006 | SNOMEDCT_US |
003934 | NDDF |
None