trifluperidol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antipsychotics, haloperidol derivatives 2741 749-13-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • trifluperidol
  • psicoperidol
  • trifluoperidol
  • trifluperol
  • triperidol
A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in the treatment of PSYCHOSES including MANIA and SCHIZOPHRENIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p621)
  • Molecular weight: 409.43
  • Formula: C22H23F4NO2
  • CLOGP: 4.02
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 40.54
  • ALOGS: -4.36
  • ROTB: 7

Drug dosage:

DoseUnitRoute
2 mg O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AD02 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Butyrophenone derivatives
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D015259 Dopamine Agents
MeSH PA D018492 Dopamine Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.36 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR Ki 9.70 PDSP
D(4) dopamine receptor GPCR Ki 9.46 PDSP
D(3) dopamine receptor GPCR Ki 8.46 PDSP
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 9.08 CHEMBL
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase Enzyme Ki 6.78 CHEMBL
C-8 sterol isomerase Enzyme Ki 9.82 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 9.10 CHEMBL

External reference:

IDSource
N0000166793 NUI
C0040988 UMLSCUI
D02625 KEGG_DRUG
5478006 SNOMEDCT_US
10804 RXNORM
387301006 SNOMEDCT_US
004060 NDDF
CHEMBL15023 ChEMBL_ID
R8869Q7R8I UNII
1604 INN_ID
CHEBI:135662 CHEBI
D014272 MESH_DESCRIPTOR_UI
DB13552 DRUGBANK_ID
5567 PUBCHEM_CID

Pharmaceutical products:

None