haloperidol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antipsychotics, haloperidol derivatives 1353 52-86-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • haloperidol
  • aloperidin
  • haloperin
  • sigaperidol
  • haloperidol lactate
A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
  • Molecular weight: 375.87
  • Formula: C21H23ClFNO2
  • CLOGP: 3.85
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 40.54
  • ALOGS: -4.93
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
8 mg O
8 mg P
3.30 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.04 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.57 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 65 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 17 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.08 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 35 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.957 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.729 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 28.445 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 16.293 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 14.320 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 37.710 % High 1
herg hERG pIC50 6.704 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 2.213 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 14.622 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 13.070 % High 1
kinase-safety-class ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MARK4,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK 47
kinase-selectivity-class AKT2,AKT3,AXL,EIF2AK3,EPHB4,GRK2,PDK4,PRKCD,SIK2 9
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.406 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.583 High 1
mh-clint Mouse hepatocyte intrinsic clearance 25.468 High 1
mppb Mouse plasma protein binding (% unbound) 14.460 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.690 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
pppb Pig plasma protein binding (% unbound) 25.700 % High 1
rat-kpuu-brain Rat brain Kpuu 0.067 % High 1
rh-clint Rat hepatocyte intrinsic clearance 58.210 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 31.420 % High 1
rppb Rat plasma protein binding (% unbound) 12.780 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 48.195 uM High 1

Approvals:

DateAgencyCompanyOrphan
April 12, 1967 FDA ORTHO MCNEIL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 2165.72 17.15 615 40277 14481 90573074
Extrapyramidal disorder 1548.25 17.15 483 40409 15820 90571735
Drug interaction 627.55 17.15 695 40197 275758 90311797
Catatonia 589.51 17.15 183 40709 5873 90581682
Intentional self-injury 573.39 17.15 275 40617 29059 90558496
Akathisia 560.38 17.15 205 40687 10954 90576601
Dystonia 512.07 17.15 215 40677 16604 90570951
Muscle rigidity 415.88 17.15 177 40715 14132 90573423
Delusion 381.80 17.15 165 40727 13675 90573880
Hyperprolactinaemia 369.09 17.15 125 40767 5308 90582247
Agitation 367.22 17.15 277 40615 66821 90520734
Psychotic disorder 353.06 17.15 203 40689 31027 90556528
Sopor 341.03 17.15 183 40709 24461 90563094
Electrocardiogram QT prolonged 333.43 17.15 270 40622 72186 90515369
Hallucination, auditory 321.92 17.15 153 40739 15822 90571733
Aggression 305.86 17.15 175 40717 26493 90561062
Psychomotor hyperactivity 293.17 17.15 134 40758 12679 90574876
Salivary hypersecretion 286.00 17.15 119 40773 8973 90578582
Tardive dyskinesia 284.19 17.15 125 40767 10805 90576750
Parkinsonism 272.12 17.15 131 40761 13934 90573621
Toxicity to various agents 250.41 17.15 458 40434 287388 90300167
Sedation 244.02 17.15 190 40702 47981 90539574
Torsade de pointes 233.46 17.15 121 40771 15061 90572494
Dyskinesia 229.53 17.15 164 40728 36370 90551185
Somnolence 220.02 17.15 362 40530 208722 90378833
Arthralgia 219.13 17.15 43 40849 778479 89809076
Hypothermia 213.61 17.15 115 40777 15460 90572095
Drug abuse 212.41 17.15 222 40670 82125 90505430
Hallucination 211.14 17.15 200 40692 65759 90521796
Schizophrenia 209.81 17.15 112 40780 14802 90572753
Joint swelling 186.44 17.15 10 40882 503290 90084265
Pain 186.12 17.15 110 40782 996231 89591324
Intentional overdose 185.27 17.15 220 40672 93614 90493941
Blood creatine phosphokinase increased 178.40 17.15 137 40755 33886 90553669
Treatment noncompliance 177.39 17.15 163 40729 51564 90535991
Delirium 175.97 17.15 226 40666 104133 90483422
Depressed level of consciousness 174.91 17.15 189 40703 72595 90514960
Suicide attempt 172.86 17.15 191 40701 75208 90512347
Tremor 171.65 17.15 273 40619 152900 90434655
Coma 157.94 17.15 179 40713 72453 90515102
Alopecia 155.62 17.15 20 40872 495051 90092504
Infusion related reaction 155.19 17.15 8 40884 416772 90170783
Swelling 153.07 17.15 9 40883 419049 90168506
Bradykinesia 152.16 17.15 70 40822 6718 90580837
Restlessness 151.44 17.15 127 40765 35593 90551962
Abdominal discomfort 143.64 17.15 22 40870 477306 90110249
Mental impairment 143.23 17.15 91 40801 16629 90570926
Psychotic symptom 141.88 17.15 49 40843 2207 90585348
Rheumatoid arthritis 141.48 17.15 5 40887 362609 90224946
Systemic lupus erythematosus 141.17 17.15 5 40887 361891 90225664
Rhabdomyolysis 139.01 17.15 142 40750 51114 90536441
Fatigue 134.50 17.15 196 40696 1153827 89433728
Abnormal behaviour 133.94 17.15 98 40794 22530 90565025
Dysarthria 130.04 17.15 141 40751 54341 90533214
Cogwheel rigidity 129.65 17.15 45 40847 2057 90585498
Overdose 129.43 17.15 245 40647 157464 90430091
Altered state of consciousness 129.32 17.15 110 40782 31422 90556133
Suicidal ideation 129.29 17.15 163 40729 73692 90513863
Rash 122.19 17.15 108 40784 795992 89791563
Pneumonia aspiration 121.28 17.15 119 40773 40821 90546734
Headache 120.87 17.15 127 40765 862619 89724936
Wound 118.80 17.15 4 40888 302976 90284579
Sinusitis 117.66 17.15 10 40882 343078 90244477
Serotonin syndrome 115.73 17.15 112 40780 37775 90549780
Nasopharyngitis 115.32 17.15 22 40870 407082 90180473
Weight increased 112.09 17.15 428 40464 417499 90170056
Pruritus 110.79 17.15 53 40839 541472 90046083
Paranoia 109.93 17.15 70 40822 12838 90574717
Pulmonary embolism 109.52 17.15 205 40687 130615 90456940
Hyponatraemia 107.75 17.15 206 40686 133332 90454223
Persecutory delusion 107.70 17.15 44 40848 3164 90584391
Pain in extremity 107.06 17.15 35 40857 450494 90137061
Tachycardia 99.78 17.15 220 40672 157453 90430102
Torticollis 99.46 17.15 39 40853 2519 90585036
Disorientation 98.05 17.15 110 40782 44004 90543551
Encephalitis autoimmune 96.62 17.15 36 40856 2022 90585533
Refusal of examination 96.53 17.15 22 40870 202 90587353
Hypertonia 93.64 17.15 46 40846 5109 90582446
Toxic epidermal necrolysis 93.46 17.15 93 40799 32435 90555120
Drug level increased 92.27 17.15 86 40806 27676 90559879
Impaired healing 92.12 17.15 3 40889 234196 90353359
Drug intolerance 91.21 17.15 44 40848 447547 90140008
Mutism 90.63 17.15 33 40859 1736 90585819
Bradyphrenia 90.06 17.15 51 40841 7561 90579994
Embolism venous 89.58 17.15 40 40852 3580 90583975
Ileus paralytic 88.28 17.15 44 40848 5041 90582514
Peripheral swelling 86.65 17.15 39 40853 413067 90174488
Oculogyric crisis 86.65 17.15 35 40857 2444 90585111
Cardiac arrest 86.02 17.15 163 40729 104772 90482783
Urinary retention 85.40 17.15 95 40797 37649 90549906
Hyperreflexia 85.29 17.15 47 40845 6610 90580945
Contraindicated product administered 85.09 17.15 20 40872 320119 90267436
Psychomotor retardation 84.80 17.15 42 40850 4747 90582808
Urticaria 84.19 17.15 19 40873 312715 90274840
Discomfort 83.93 17.15 12 40880 274323 90313232
Mania 83.20 17.15 61 40831 14063 90573492
Pericarditis 82.22 17.15 12 40880 270139 90317416
Bradycardia 81.15 17.15 140 40752 83707 90503848
Hyperthermia 80.51 17.15 53 40839 10282 90577273
Galactorrhoea 79.85 17.15 40 40852 4632 90582923
Lethargy 79.71 17.15 119 40773 63020 90524535
Hypersensitivity 79.36 17.15 54 40838 454623 90132932
Drooling 77.93 17.15 39 40853 4507 90583048
Unresponsive to stimuli 77.87 17.15 91 40801 38030 90549525
Hepatic enzyme increased 77.31 17.15 33 40859 360703 90226852
Stupor 76.62 17.15 41 40851 5441 90582114
Stereotypy 76.35 17.15 21 40871 435 90587120
Folliculitis 75.75 17.15 4 40888 204349 90383206
Myocarditis 75.45 17.15 57 40835 13749 90573806
Myoclonus 72.78 17.15 64 40828 19104 90568451
Polydipsia 71.65 17.15 36 40856 4195 90583360
Negativism 71.45 17.15 20 40872 443 90587112
Oromandibular dystonia 70.55 17.15 21 40871 582 90586973
Malignant catatonia 69.35 17.15 17 40875 219 90587336
Cognitive disorder 68.62 17.15 117 40775 69290 90518265
Osteoarthritis 66.26 17.15 6 40886 195724 90391831
Contusion 66.14 17.15 16 40876 251200 90336355
Eosinophil count decreased 65.41 17.15 31 40861 3181 90584374
Confusional state 64.57 17.15 344 40548 385861 90201694
Intentional product misuse 63.54 17.15 131 40761 89473 90498082
Arthritis 62.88 17.15 3 40889 167312 90420243
Ill-defined disorder 61.70 17.15 6 40886 184885 90402670
Mental status changes 60.43 17.15 87 40805 44592 90542963
Respiratory failure 59.42 17.15 151 40741 118267 90469288
Stomatitis 59.04 17.15 25 40867 274673 90312882
Asthma 58.91 17.15 18 40874 242142 90345413
Musculoskeletal pain 58.64 17.15 5 40887 171246 90416309
Type 2 diabetes mellitus 57.46 17.15 11 40881 203233 90384322
Behaviour disorder 57.40 17.15 32 40860 4603 90582952
Wheezing 57.37 17.15 18 40874 238062 90349493
Abdominal pain upper 57.36 17.15 40 40852 332634 90254921
Hallucination, visual 57.25 17.15 61 40831 23031 90564524
Dysphagia 57.20 17.15 144 40748 112134 90475421
Infection 56.75 17.15 48 40844 362046 90225509
Cardio-respiratory arrest 56.65 17.15 102 40790 63038 90524517
Inappropriate antidiuretic hormone secretion 56.46 17.15 56 40836 19449 90568106
Hypernatraemia 56.33 17.15 41 40851 9346 90578209
Myocardial reperfusion injury 55.95 17.15 13 40879 131 90587424
Leukopenia 55.37 17.15 133 40759 100577 90486978
Neutropenia 55.03 17.15 224 40668 224680 90362875
Psoriasis 54.41 17.15 3 40889 147751 90439804
Paraesthesia 53.44 17.15 23 40869 250303 90337252
Dyspepsia 53.38 17.15 12 40880 198148 90389407
Hypoaesthesia 52.57 17.15 39 40853 314171 90273384
Gestational diabetes 51.95 17.15 41 40851 10541 90577014
Hyperammonaemic encephalopathy 51.77 17.15 25 40867 2674 90584881
Therapeutic product effect decreased 51.07 17.15 31 40861 277540 90310015
Leukocytosis 50.44 17.15 66 40826 30924 90556631
Mental disorder 49.78 17.15 67 40825 32251 90555304
Inflammation 49.78 17.15 10 40882 178582 90408973
Apraxia 49.67 17.15 23 40869 2239 90585316
Echolalia 49.64 17.15 14 40878 319 90587236
Injury 49.21 17.15 14 40878 197335 90390220
Hypoxic-ischaemic encephalopathy 49.17 17.15 29 40863 4639 90582916
Seizure 49.03 17.15 166 40726 152463 90435092
Clonus 48.50 17.15 31 40861 5719 90581836
Hemianopia 48.32 17.15 22 40870 2060 90585495
Blood cholesterol increased 47.88 17.15 17 40875 207995 90379560
Mobility decreased 47.54 17.15 27 40865 250707 90336848
Sluggishness 47.49 17.15 31 40861 5928 90581627
Blood prolactin increased 47.48 17.15 26 40866 3611 90583944
Distractibility 46.54 17.15 15 40877 544 90587011
Waxy flexibility 45.75 17.15 11 40881 130 90587425
C-reactive protein abnormal 45.67 17.15 3 40889 127426 90460129
Hallucinations, mixed 45.39 17.15 30 40862 5859 90581696
Liver injury 44.62 17.15 11 40881 170556 90416999
Sinus bradycardia 44.20 17.15 46 40846 16906 90570649
Faecaloma 44.01 17.15 37 40855 10394 90577161
Antipsychotic drug level increased 43.84 17.15 25 40867 3754 90583801
Disturbance in attention 43.41 17.15 77 40815 47032 90540523
Lower respiratory tract infection 43.37 17.15 30 40862 250629 90336926
Poisoning 42.77 17.15 43 40849 15174 90572381
Completed suicide 42.46 17.15 153 40739 144905 90442650
Impulsive behaviour 42.44 17.15 19 40873 1711 90585844
Sexually inappropriate behaviour 41.76 17.15 10 40882 116 90587439
Refusal of treatment by patient 41.26 17.15 28 40864 5710 90581845
Hypersexuality 40.93 17.15 14 40878 612 90586943
Hyperthermia malignant 40.85 17.15 17 40875 1281 90586274
Social avoidant behaviour 40.73 17.15 23 40869 3390 90584165
Haemoglobin urine 40.43 17.15 10 40882 134 90587421
Injection site pain 40.31 17.15 14 40878 173685 90413870
Treatment failure 39.91 17.15 47 40845 303881 90283674
Chest pain 39.28 17.15 52 40840 319593 90267962
Neutrophil count increased 39.11 17.15 46 40846 19344 90568211
Speech disorder 38.81 17.15 72 40820 45513 90542042
Miosis 38.70 17.15 33 40859 9451 90578104
Withdrawal syndrome 38.26 17.15 49 40843 22475 90565080
Head titubation 37.87 17.15 16 40876 1252 90586303
Encephalopathy 37.85 17.15 72 40820 46372 90541183
Autonomic nervous system imbalance 37.83 17.15 22 40870 3428 90584127
Metabolic syndrome 37.82 17.15 18 40874 1864 90585691
Apallic syndrome 37.64 17.15 14 40878 782 90586773
Somatic symptom disorder of pregnancy 37.61 17.15 9 40883 104 90587451
Oedema 37.35 17.15 22 40870 200273 90387282
Multiple organ dysfunction syndrome 37.29 17.15 90 40802 68246 90519309
Grandiosity 37.19 17.15 11 40881 298 90587257
Cannabinoid hyperemesis syndrome 36.78 17.15 8 40884 58 90587497
Wound infection 36.72 17.15 3 40889 106399 90481156
Lung disorder 36.69 17.15 11 40881 149872 90437683
Negative symptoms in schizophrenia 36.29 17.15 9 40883 122 90587433
Feeling guilty 36.24 17.15 13 40879 655 90586900
Tonic clonic movements 36.24 17.15 17 40875 1705 90585850
Illogical thinking 36.08 17.15 8 40884 64 90587491
Dyspnoea 35.70 17.15 242 40650 880713 89706842
Dizziness 35.64 17.15 141 40751 589143 89998412
Back pain 35.61 17.15 55 40837 317120 90270435
White blood cell count increased 35.03 17.15 87 40805 67154 90520401
Sudden death 34.72 17.15 33 40859 10876 90576679
Diarrhoea 34.20 17.15 266 40626 938924 89648631
Irritability 33.77 17.15 59 40833 35603 90551952
Product dose omission issue 33.30 17.15 50 40842 291637 90295918
Dry mouth 33.22 17.15 21 40871 184038 90403517
Eosinophil count abnormal 32.95 17.15 13 40879 853 90586702
Vulvovaginal candidiasis 32.83 17.15 21 40871 3879 90583676
Hypotension 32.74 17.15 255 40637 325142 90262413
Amenorrhoea 32.72 17.15 33 40859 11689 90575866
Bronchitis 32.71 17.15 14 40878 152913 90434642
Neurotoxicity 32.30 17.15 44 40848 21423 90566132
Brain death 32.24 17.15 21 40871 4000 90583555
Mucosal dryness 31.60 17.15 19 40873 3148 90584407
Respiratory depression 31.50 17.15 37 40855 15538 90572017
Movement disorder 31.46 17.15 51 40841 28968 90558587
Red blood cells urine 31.11 17.15 11 40881 531 90587024
Nuchal rigidity 30.79 17.15 12 40880 762 90586793
Dermatitis exfoliative 30.56 17.15 23 40869 5513 90582042
Gastrooesophageal reflux disease 29.99 17.15 19 40873 166318 90421237
Schizoaffective disorder 29.79 17.15 22 40870 5125 90582430
Asthenia 29.61 17.15 132 40760 533619 90053936
Electrocardiogram PR prolongation 29.43 17.15 12 40880 858 90586697
Herpes zoster 29.25 17.15 4 40888 94640 90492915
Femoral neck fracture 28.91 17.15 29 40863 10204 90577351
Electrolyte imbalance 28.88 17.15 44 40848 23701 90563854
Blister 28.82 17.15 44 40848 254954 90332601
Euphoric mood 28.82 17.15 22 40870 5387 90582168
Nephrogenic diabetes insipidus 28.17 17.15 12 40880 958 90586597
Blood phosphorus decreased 27.98 17.15 21 40871 5013 90582542
Weight decreased 27.60 17.15 84 40808 379826 90207729
Chest discomfort 27.53 17.15 14 40878 138351 90449204
Reduced facial expression 27.25 17.15 16 40876 2537 90585018
Electroencephalogram abnormal 27.13 17.15 19 40873 4077 90583478
False positive investigation result 27.04 17.15 11 40881 782 90586773
Impaired gastric emptying 26.86 17.15 31 40861 12778 90574777
Disorganised speech 26.07 17.15 14 40878 1871 90585684
Duodenal stenosis 25.89 17.15 10 40882 620 90586935
Generalised tonic-clonic seizure 25.88 17.15 52 40840 34851 90552704
Psychiatric decompensation 25.67 17.15 14 40878 1929 90585626
Eosinophilia 25.47 17.15 46 40846 28487 90559068
Myalgia 25.28 17.15 25 40867 175100 90412455
Tachypnoea 25.24 17.15 39 40853 21270 90566285
Venous thrombosis limb 25.15 17.15 17 40875 3445 90584110
Differential white blood cell count abnormal 24.82 17.15 11 40881 967 90586588
Injection site erythema 24.52 17.15 7 40885 98495 90489060
Lactate pyruvate ratio increased 24.36 17.15 6 40886 79 90587476
Megacolon 23.96 17.15 14 40878 2200 90585355
Cough 23.75 17.15 86 40806 368876 90218679
Influenza 23.64 17.15 17 40875 139247 90448308
Urinary bladder rupture 23.52 17.15 7 40885 194 90587361
Granulocytopenia 23.44 17.15 21 40871 6420 90581135
Anticonvulsant drug level above therapeutic 23.27 17.15 9 40883 560 90586995
Urinary incontinence 23.26 17.15 52 40840 37514 90550041
Protrusion tongue 23.23 17.15 8 40884 357 90587198
Psychomotor skills impaired 23.03 17.15 15 40877 2857 90584698
Glomerular filtration rate decreased 22.93 17.15 33 40859 16899 90570656
Opisthotonus 22.77 17.15 8 40884 379 90587176
Nausea 22.60 17.15 359 40533 1109957 89477598
Hepatocellular injury 22.50 17.15 44 40848 28914 90558641
Polyglandular disorder 22.47 17.15 7 40885 227 90587328
Fluid retention 22.42 17.15 6 40886 88085 90499470
Muscle enzyme increased 22.29 17.15 7 40885 233 90587322
Gastrointestinal disorder 22.23 17.15 52 40840 256635 90330920
Muscular weakness 22.09 17.15 37 40855 206629 90380926
Brain injury 21.99 17.15 22 40870 7716 90579839
Apathy 21.95 17.15 26 40866 11014 90576541
Haematochezia 21.91 17.15 3 40889 70910 90516645
Coma scale abnormal 21.79 17.15 19 40873 5607 90581948
Stress 21.77 17.15 5 40887 81390 90506165
Delusion of reference 21.65 17.15 6 40886 128 90587427
Screaming 21.64 17.15 16 40876 3734 90583821
Croup infectious 21.63 17.15 9 40883 678 90586877
Acute kidney injury 21.46 17.15 230 40662 320157 90267398
Volvulus 21.42 17.15 13 40879 2190 90585365
Blunted affect 21.30 17.15 7 40885 270 90587285
Blood citric acid increased 21.29 17.15 5 40887 53 90587502
Electroconvulsive therapy 21.04 17.15 5 40887 56 90587499
Drug resistance 20.97 17.15 44 40848 30405 90557150
Intestinal dilatation 20.85 17.15 13 40879 2297 90585258
Grimacing 20.79 17.15 8 40884 491 90587064
Depressive symptom 20.77 17.15 18 40874 5267 90582288
Dementia 20.70 17.15 38 40854 23823 90563732
Pressure of speech 20.64 17.15 9 40883 761 90586794
Major depression 20.56 17.15 24 40868 10011 90577544
Respiratory alkalosis 20.55 17.15 15 40877 3433 90584122
Paroxysmal perceptual alteration 20.50 17.15 5 40887 63 90587492
Brief psychotic disorder with marked stressors 20.50 17.15 5 40887 63 90587492
Substance-induced psychotic disorder 20.44 17.15 14 40878 2898 90584657
Persistent postural-perceptual dizziness 20.39 17.15 4 40888 16 90587539
Dyspnoea exertional 20.23 17.15 4 40888 72284 90515271
Rash pruritic 20.18 17.15 6 40886 82208 90505347
Carnitine deficiency 19.77 17.15 6 40886 178 90587377
Sleep disorder 19.76 17.15 37 40855 197993 90389562
Acute psychosis 19.74 17.15 14 40878 3064 90584491
Muscle spasms 19.51 17.15 54 40838 251829 90335726
Resting tremor 19.46 17.15 9 40883 874 90586681
Neutrophilia 19.39 17.15 18 40874 5760 90581795
Chorea 19.36 17.15 12 40880 2098 90585457
Hypokalaemia 19.32 17.15 113 40779 131003 90456552
Ureteric obstruction 19.32 17.15 12 40880 2106 90585449
Staring 19.25 17.15 11 40881 1659 90585896
Tongue biting 19.24 17.15 12 40880 2121 90585434
Product use issue 19.24 17.15 80 40812 329839 90257716
Self-medication 19.17 17.15 14 40878 3206 90584349
Thinking abnormal 19.11 17.15 25 40867 11707 90575848
Flushing 19.08 17.15 8 40884 88483 90499072
Epileptic encephalopathy 18.98 17.15 7 40885 382 90587173
Nasal congestion 18.87 17.15 7 40885 83407 90504148
Drug reaction with eosinophilia and systemic symptoms 18.87 17.15 52 40840 42706 90544849
Akinesia 18.85 17.15 11 40881 1725 90585830
Granulomatous liver disease 18.84 17.15 9 40883 940 90586615
Hypertension 18.81 17.15 125 40767 457407 90130148
Injection site reaction 18.79 17.15 9 40883 92071 90495484
Poor personal hygiene 18.77 17.15 7 40885 394 90587161
CYP2C19 polymorphism 18.64 17.15 4 40888 27 90587528
Migraine 18.63 17.15 36 40856 190356 90397199
Muscle strength abnormal 18.59 17.15 5 40887 95 90587460
Cholecystitis 18.54 17.15 30 40862 17010 90570545
Rebound effect 18.49 17.15 22 40870 9362 90578193
Eosinophilic myocarditis 18.34 17.15 8 40884 677 90586878
Eye movement disorder 18.32 17.15 18 40874 6180 90581375
Hyperthyroidism 18.26 17.15 31 40861 18279 90569276
Hypophagia 18.19 17.15 46 40846 35891 90551664
Psychiatric symptom 17.99 17.15 19 40873 7099 90580456
Blood glucose 17.93 17.15 4 40888 33 90587522
Influenza like illness 17.85 17.15 7 40885 80604 90506951
Hyperkinesia 17.83 17.15 11 40881 1908 90585647
Foetal exposure during pregnancy 17.72 17.15 51 40841 42924 90544631
Fanconi syndrome 17.70 17.15 11 40881 1932 90585623
Flight of ideas 17.69 17.15 7 40885 463 90587092
Ventricular arrhythmia 17.56 17.15 15 40877 4306 90583249
Anger 17.51 17.15 26 40866 13694 90573861
Fall 17.51 17.15 310 40582 481500 90106055
Osteoporosis 17.43 17.15 11 40881 96520 90491035
Narcolepsy 17.41 17.15 10 40882 1522 90586033
Depressed mood 17.34 17.15 56 40836 50166 90537389
Labelled drug-food interaction medication error 17.29 17.15 6 40886 274 90587281
Arrhythmia 17.23 17.15 50 40842 42282 90545273

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 2294.73 14.59 909 54342 20563 42545521
Extrapyramidal disorder 1862.58 14.59 726 54525 15686 42550398
Dystonia 818.53 14.59 377 54874 12413 42553671
Akathisia 731.71 14.59 328 54923 10123 42555961
Muscle rigidity 492.76 14.59 262 54989 11797 42554287
Sedation 489.26 14.59 366 54885 30109 42535975
Catatonia 475.87 14.59 208 55043 6031 42560053
Intentional self-injury 430.96 14.59 260 54991 14942 42551142
Delirium 395.28 14.59 410 54841 52109 42513975
Tardive dyskinesia 384.04 14.59 185 55066 6739 42559345
Parkinsonism 376.28 14.59 210 55041 10413 42555671
Psychotic disorder 376.13 14.59 308 54943 28900 42537184
Weight increased 369.20 14.59 568 54683 107415 42458669
Hallucination, auditory 352.55 14.59 227 55024 14637 42551447
Agitation 345.14 14.59 421 54830 63893 42502191
Salivary hypersecretion 341.07 14.59 199 55052 10744 42555340
Hyperprolactinaemia 320.85 14.59 116 55135 2007 42564077
Delusion 286.77 14.59 199 55052 14535 42551549
Antipsychotic drug level below therapeutic 281.19 14.59 118 55133 3086 42562998
Suicide attempt 279.01 14.59 321 54930 45779 42520305
Drug interaction 260.31 14.59 848 54403 266151 42299933
Disinhibition 259.04 14.59 118 55133 3777 42562307
Obsessive-compulsive disorder 257.20 14.59 140 55111 6603 42559481
Aggression 251.38 14.59 298 54953 43865 42522219
Electrocardiogram QT prolonged 230.20 14.59 297 54954 47648 42518436
Treatment noncompliance 224.02 14.59 260 54991 37412 42528672
Sopor 223.94 14.59 164 55087 13038 42553046
Therapeutic product effect variable 218.84 14.59 98 55153 3011 42563073
Schizophrenia 215.93 14.59 147 55104 10403 42555681
Blood creatine phosphokinase increased 215.91 14.59 289 54962 48049 42518035
Tachycardia 209.24 14.59 427 54824 100660 42465424
Emotional poverty 204.03 14.59 63 55188 649 42565435
Euphoric mood 197.49 14.59 116 55135 6337 42559747
Toxicity to various agents 195.99 14.59 697 54554 228439 42337645
Increased appetite 186.81 14.59 126 55125 8780 42557304
Dyskinesia 169.25 14.59 186 55065 25204 42540880
Delusion of grandeur 166.78 14.59 71 55180 1925 42564159
Somnolence 156.26 14.59 469 54782 140636 42425448
Rhabdomyolysis 155.98 14.59 325 54926 77694 42488390
Rash 155.16 14.59 83 55168 276871 42289213
Pneumonia aspiration 155.03 14.59 252 54999 49826 42516258
Arthralgia 152.64 14.59 39 55212 205199 42360885
Hyperthermia 150.15 14.59 127 55124 12447 42553637
Priapism 147.33 14.59 96 55155 6311 42559773
Tremor 146.14 14.59 361 54890 96568 42469516
Dyspnoea 140.20 14.59 224 55027 442397 42123687
Restlessness 126.16 14.59 172 55079 29077 42537007
Psychomotor hyperactivity 125.37 14.59 108 55143 10850 42555234
Cogwheel rigidity 124.30 14.59 56 55195 1745 42564339
Headache 120.99 14.59 81 55170 239288 42326796
Diarrhoea 118.83 14.59 264 54987 460585 42105499
Fatigue 118.61 14.59 242 55009 435399 42130685
Mental impairment 116.42 14.59 109 55142 12208 42553876
Serotonin syndrome 116.06 14.59 155 55096 25690 42540394
Oculogyric crisis 112.74 14.59 52 55199 1713 42564371
Dizziness 112.30 14.59 95 55156 249159 42316925
Malignant catatonia 108.21 14.59 35 55216 424 42565660
Myocarditis 106.37 14.59 127 55124 18811 42547273
Spasmodic dysphonia 103.86 14.59 35 55216 486 42565598
Hypertonia 103.07 14.59 70 55181 4931 42561153
Altered state of consciousness 102.66 14.59 156 55095 29103 42536981
Febrile neutropenia 97.67 14.59 60 55191 185643 42380441
Dysphagia 97.28 14.59 259 54992 72460 42493624
Embolism venous 96.89 14.59 48 55203 1858 42564226
Affective disorder 96.47 14.59 72 55179 5888 42560196
Psychotic symptom 94.97 14.59 51 55200 2339 42563745
Anaemia 94.16 14.59 136 55115 280142 42285942
Coma 93.16 14.59 211 55040 53343 42512741
Rhinalgia 92.44 14.59 46 55205 1798 42564286
Intentional overdose 92.04 14.59 205 55046 51251 42514833
Hypothermia 90.96 14.59 96 55155 12419 42553665
Pain in extremity 90.46 14.59 41 55210 150563 42415521
Pain 90.17 14.59 111 55140 244737 42321347
Leukopenia 87.90 14.59 254 54997 74492 42491592
Leukaemia 87.39 14.59 67 55184 5705 42560379
Cough 86.31 14.59 63 55188 178040 42388044
Asthenia 85.97 14.59 145 55106 280648 42285436
Mania 85.87 14.59 86 55165 10461 42555623
Lymphocyte count abnormal 85.04 14.59 46 55205 2141 42563943
Nausea 83.92 14.59 251 55000 396548 42169536
Depressed level of consciousness 83.43 14.59 189 55062 47781 42518303
Overdose 81.11 14.59 310 54941 104954 42461130
Dyslipidaemia 80.77 14.59 79 55172 9339 42556745
Back pain 79.97 14.59 42 55209 141734 42424350
Hallucination 79.11 14.59 207 55044 57300 42508784
Abnormal behaviour 78.96 14.59 131 55120 26320 42539764
Schizoaffective disorder 78.17 14.59 42 55209 1928 42564156
Prescribed overdose 78.09 14.59 90 55161 12837 42553247
Product dose omission issue 76.89 14.59 53 55198 154312 42411772
Ileus paralytic 76.82 14.59 70 55181 7571 42558513
Drooling 76.51 14.59 55 55196 4244 42561840
Myoclonus 76.08 14.59 102 55149 16963 42549121
Pruritus 75.51 14.59 80 55171 188691 42377393
Blood prolactin abnormal 73.43 14.59 33 55218 1022 42565062
Dysarthria 72.77 14.59 160 55091 39647 42526437
Nasopharyngitis 72.76 14.59 11 55240 83985 42482099
Psychosexual disorder 72.73 14.59 20 55231 131 42565953
Neutrophil count increased 71.47 14.59 107 55144 19697 42546387
Persecutory delusion 71.35 14.59 49 55202 3515 42562569
Bradykinesia 69.23 14.59 57 55194 5379 42560705
Social avoidant behaviour 69.12 14.59 47 55204 3317 42562767
Oromandibular dystonia 68.87 14.59 27 55224 589 42565495
Torticollis 68.15 14.59 34 55217 1336 42564748
Cardiac failure congestive 68.07 14.59 14 55237 85588 42480496
Irritability 68.02 14.59 127 55124 28001 42538083
Protrusion tongue 67.51 14.59 21 55230 222 42565862
Myocardial infarction 66.65 14.59 39 55212 123970 42442114
Antipsychotic drug level increased 65.94 14.59 52 55199 4614 42561470
Autonomic nervous system imbalance 65.13 14.59 44 55207 3072 42563012
Paranoia 64.31 14.59 85 55166 13941 42552143
Confusional state 63.56 14.59 403 54848 167194 42398890
Cognitive disorder 63.19 14.59 138 55113 34034 42532050
Infusion related reaction 62.95 14.59 4 55247 60802 42505282
Pneumonia 62.15 14.59 309 54942 421840 42144244
Blood prolactin increased 61.74 14.59 38 55213 2260 42563824
Paroxysmal perceptual alteration 60.24 14.59 19 55232 211 42565873
Erythema 60.21 14.59 33 55218 108760 42457324
Choking 60.02 14.59 56 55195 6242 42559842
Psychomotor retardation 59.97 14.59 48 55203 4351 42561733
Hyperreflexia 59.33 14.59 44 55207 3563 42562521
Disorientation 57.38 14.59 138 55113 36251 42529833
Oropharyngeal spasm 56.90 14.59 18 55233 202 42565882
Death 56.37 14.59 369 54882 470816 42095268
Drug ineffective 56.09 14.59 1135 54116 629062 41937022
Intestinal pseudo-obstruction 54.83 14.59 35 55216 2220 42563864
Mutism 54.76 14.59 30 55221 1432 42564652
Cerebrovascular accident 52.99 14.59 30 55221 97130 42468954
Leukocytosis 52.70 14.59 118 55133 29590 42536494
Torsade de pointes 52.19 14.59 60 55191 8534 42557550
Trismus 51.56 14.59 37 55214 2847 42563237
Injection site pain 51.37 14.59 7 55244 57791 42508293
Suicidal ideation 51.22 14.59 158 55093 48003 42518081
Withdrawal syndrome 50.72 14.59 78 55173 14697 42551387
Asthma 49.93 14.59 10 55241 62304 42503780
Self-injurious ideation 47.93 14.59 30 55221 1838 42564246
Urticaria 47.90 14.59 18 55233 74018 42492066
Peripheral swelling 47.63 14.59 29 55222 90241 42475843
Obesity 47.10 14.59 80 55171 16379 42549705
Intentional product misuse 46.57 14.59 181 55070 61719 42504365
Speech disorder 46.52 14.59 111 55140 29010 42537074
Sinusitis 46.42 14.59 4 55247 47288 42518796
Bruxism 46.23 14.59 31 55220 2138 42563946
Oscillopsia 45.92 14.59 16 55235 247 42565837
Rebound effect 45.62 14.59 52 55199 7327 42558757
Joint swelling 44.92 14.59 16 55235 68006 42498078
Resting tremor 44.43 14.59 23 55228 978 42565106
Stupor 44.26 14.59 35 55216 3118 42562966
Epistaxis 43.65 14.59 16 55235 66810 42499274
White blood cell count increased 43.46 14.59 143 55108 44944 42521140
Eye movement disorder 43.37 14.59 42 55209 4903 42561181
Rheumatoid arthritis 43.31 14.59 3 55248 42437 42523647
Drug withdrawal syndrome 43.27 14.59 90 55161 21459 42544625
Completed suicide 42.95 14.59 242 55009 96223 42469861
Visceral congestion 42.86 14.59 22 55229 919 42565165
Influenza 42.13 14.59 14 55237 62161 42503923
Interstitial lung disease 41.68 14.59 25 55226 78437 42487647
Encephalitis toxic 41.35 14.59 15 55236 262 42565822
Cardio-respiratory arrest 41.33 14.59 168 55083 58468 42507616
Waxy flexibility 41.12 14.59 12 55239 100 42565984
Sexual dysfunction 40.63 14.59 47 55204 6728 42559356
Chest discomfort 40.27 14.59 16 55235 63600 42502484
Sedation complication 40.11 14.59 32 55219 2887 42563197
Arthritis 40.10 14.59 4 55247 42061 42524023
Urinary retention 39.89 14.59 133 55118 42081 42524003
Hyperventilation 39.76 14.59 33 55218 3149 42562935
Intentional product use issue 39.42 14.59 22 55229 71811 42494273
Thrombosis 39.04 14.59 20 55231 68491 42497593
Water intoxication 38.64 14.59 16 55235 404 42565680
Abdominal discomfort 38.56 14.59 25 55226 75230 42490854
Wrong patient received product 38.33 14.59 34 55217 3549 42562535
Refusal of treatment by patient 37.40 14.59 40 55211 5251 42560833
Peptostreptococcus infection 37.12 14.59 10 55241 60 42566024
Coronary artery disease 36.57 14.59 12 55239 53708 42512376
Herpes zoster 36.28 14.59 4 55247 38873 42527211
Seizure 36.25 14.59 274 54977 120287 42445797
Dry skin 36.22 14.59 9 55242 48329 42517755
Inappropriate schedule of product administration 35.73 14.59 43 55208 95859 42470225
Myelosuppression 35.72 14.59 5 55246 40456 42525628
Mental status changes 34.86 14.59 127 55124 41988 42524096
Nephrogenic diabetes insipidus 34.76 14.59 23 55228 1551 42564533
Decreased appetite 34.64 14.59 131 55120 193006 42373078
Tic 34.63 14.59 27 55224 2356 42563728
Inappropriate antidiuretic hormone secretion 34.28 14.59 70 55181 16471 42549613
Paraesthesia 34.24 14.59 27 55224 73432 42492652
Haemorrhage 34.03 14.59 18 55233 60545 42505539
Neglect of personal appearance 33.71 14.59 14 55237 356 42565728
Hypoaesthesia 33.64 14.59 26 55225 71437 42494647
SARS-CoV-2 test positive 33.24 14.59 47 55204 8213 42557871
Oedema peripheral 33.23 14.59 80 55171 135996 42430088
Oral discharge 32.69 14.59 11 55240 152 42565932
Granulocytopenia 32.44 14.59 43 55208 7071 42559013
Bradyphrenia 32.39 14.59 37 55214 5225 42560859
Opisthotonus 32.32 14.59 16 55235 618 42565466
Sinus tachycardia 32.20 14.59 78 55173 20575 42545509
Product packaging issue 32.18 14.59 17 55234 754 42565330
Anticholinergic syndrome 32.17 14.59 22 55229 1567 42564517
Porphyria acute 32.13 14.59 14 55237 402 42565682
Tachypnoea 31.86 14.59 80 55171 21582 42544502
Atrial fibrillation 31.81 14.59 85 55166 139508 42426576
Ascites 31.62 14.59 17 55234 56661 42509423
Huntington's disease 30.92 14.59 8 55243 40 42566044
Thinking abnormal 30.69 14.59 42 55209 7119 42558965
Patient restraint 30.53 14.59 9 55242 78 42566006
Compulsive sexual behaviour 30.39 14.59 12 55239 267 42565817
Prostate cancer 30.34 14.59 10 55241 44633 42521451
Chest pain 30.28 14.59 87 55164 139443 42426641
Lymphocyte count decreased 30.27 14.59 92 55159 27717 42538367
Drug level increased 29.77 14.59 88 55163 26112 42539972
Apathy 29.73 14.59 45 55206 8361 42557723
Pancytopenia 29.72 14.59 68 55183 117675 42448409
Chronic obstructive pulmonary disease 29.66 14.59 23 55228 63091 42502993
Tension 29.64 14.59 25 55226 2439 42563645
Blunted affect 29.50 14.59 13 55238 384 42565700
Weight decreased 29.47 14.59 154 55097 207794 42358290
Schizoaffective disorder bipolar type 29.28 14.59 10 55241 145 42565939
Cardiac arrest 28.77 14.59 241 55010 109079 42457005
Faecaloma 28.74 14.59 38 55213 6232 42559852
Posturing 28.57 14.59 14 55237 529 42565555
Generalised tonic-clonic seizure 28.46 14.59 87 55164 26292 42539792
Dysgeusia 28.42 14.59 5 55246 34184 42531900
Substance-induced psychotic disorder 28.13 14.59 26 55225 2863 42563221
Disturbance in attention 28.13 14.59 94 55157 29772 42536312
Dextrocardia 27.93 14.59 8 55243 62 42566022
Haematochezia 27.84 14.59 21 55230 58415 42507669
Nasal congestion 27.62 14.59 3 55248 29498 42536586
Colitis ischaemic 27.44 14.59 40 55211 7186 42558898
Mental disorder 26.95 14.59 67 55184 17962 42548122
Angina pectoris 26.94 14.59 5 55246 32891 42533193
Stomatitis 26.78 14.59 16 55235 50313 42515771
Self-destructive behaviour 26.66 14.59 12 55239 373 42565711
Antipsychotic drug level above therapeutic 26.52 14.59 18 55233 1266 42564818
Psoriasis 26.50 14.59 15 55236 48589 42517495
Postoperative respiratory failure 26.44 14.59 9 55242 129 42565955
Cytomegalovirus infection 26.27 14.59 5 55246 32301 42533783
Malignant neoplasm progression 26.24 14.59 64 55187 108336 42457748
Pyramidal tract syndrome 25.95 14.59 11 55240 295 42565789
Colitis 25.93 14.59 14 55237 46558 42519526
Abdominal pain upper 25.82 14.59 42 55209 82567 42483517
Cholinergic syndrome 25.77 14.59 14 55237 657 42565427
Foetal alcohol syndrome 25.77 14.59 8 55243 84 42566000
Wheezing 25.70 14.59 20 55231 54761 42511323
Body temperature increased 25.68 14.59 71 55180 20287 42545797
Blood pressure increased 25.61 14.59 59 55192 101869 42464215
Musculoskeletal pain 25.39 14.59 6 55245 33334 42532750
Muscle contractions involuntary 25.21 14.59 21 55230 2013 42564071
Bronchitis 25.12 14.59 15 55236 47186 42518898
Acute myocardial infarction 25.12 14.59 23 55228 58142 42507942
Sluggishness 25.01 14.59 28 55223 3868 42562216
Hyperammonaemia 24.88 14.59 40 55211 7826 42558258
Symptom masked 24.77 14.59 15 55236 866 42565218
Chorea 24.62 14.59 18 55233 1426 42564658
Labile blood pressure 24.44 14.59 14 55237 729 42565355
Hypersensitivity 24.34 14.59 35 55216 72335 42493749
Drug ineffective for unapproved indication 24.07 14.59 121 55130 46042 42520042
Exhibitionism 23.92 14.59 7 55244 59 42566025
Multiple organ dysfunction syndrome 23.71 14.59 57 55194 96978 42469106
Red blood cell sedimentation rate decreased 23.70 14.59 10 55241 265 42565819
Colitis ulcerative 23.66 14.59 3 55248 26172 42539912
Vascular stenosis 23.59 14.59 9 55242 182 42565902
Gout 23.55 14.59 4 55247 28051 42538033
HIV peripheral neuropathy 23.53 14.59 6 55245 28 42566056
Pharyngeal dystonia 23.51 14.59 7 55244 63 42566021
Therapeutic product effect incomplete 23.47 14.59 165 55086 70774 42495310
Intestinal obstruction 23.41 14.59 83 55168 27075 42539009
Hyperkalaemia 23.23 14.59 43 55208 80415 42485669
Gastrointestinal disorder 23.22 14.59 16 55235 46637 42519447
Condition aggravated 23.10 14.59 470 54781 260284 42305800
Sudden death 22.99 14.59 60 55191 16569 42549515
Abdominal pain 22.74 14.59 149 55102 190322 42375762
Muscle contracture 22.48 14.59 17 55234 1418 42564666
Rapid eye movement sleep behaviour disorder 22.39 14.59 10 55241 305 42565779
Loss of personal independence in daily activities 22.35 14.59 19 55232 49797 42516287
Hyponatraemia 22.25 14.59 215 55036 101247 42464837
Blood pressure fluctuation 22.23 14.59 4 55247 26904 42539180
Sexual abuse 22.09 14.59 8 55243 139 42565945
Pulmonary fibrosis 21.97 14.59 4 55247 26677 42539407
Polydipsia 21.82 14.59 28 55223 4460 42561624
Chills 21.63 14.59 57 55194 94009 42472075
Fluid retention 21.63 14.59 7 55244 31612 42534472
Psychiatric decompensation 21.57 14.59 27 55224 4195 42561889
Reduced facial expression 21.48 14.59 17 55234 1516 42564568
Haemoptysis 21.47 14.59 17 55234 46150 42519934
Coma scale abnormal 21.44 14.59 28 55223 4537 42561547
Sexually inappropriate behaviour 21.19 14.59 12 55239 611 42565473
Acute kidney injury 21.15 14.59 342 54909 366995 42199089
Haemoglobin decreased 21.14 14.59 94 55157 132377 42433707
Patient elopement 21.00 14.59 8 55243 161 42565923
Wolff-Parkinson-White syndrome 20.97 14.59 9 55242 249 42565835
Rectal haemorrhage 20.97 14.59 20 55231 49586 42516498
Hallucinations, mixed 20.88 14.59 24 55227 3411 42562673
Respiratory alkalosis 20.73 14.59 20 55231 2324 42563760
Hostility 20.72 14.59 13 55238 800 42565284
Galactorrhoea 20.69 14.59 11 55240 494 42565590
Antipsychotic drug level decreased 20.63 14.59 15 55236 1178 42564906
Encephalopathy 20.61 14.59 107 55144 41226 42524858
Drug abuse 20.56 14.59 217 55034 104554 42461530
Migraine 20.52 14.59 4 55247 25410 42540674
Hyperhidrosis 20.44 14.59 193 55058 90319 42475765
Penis disorder 20.31 14.59 16 55235 1417 42564667
Dyspnoea exertional 20.30 14.59 21 55230 50127 42515957
Acute psychosis 20.27 14.59 19 55232 2130 42563954
Pneumocystis jirovecii pneumonia 20.25 14.59 4 55247 25177 42540907
Illusion 20.25 14.59 14 55237 1015 42565069
Renal impairment 20.24 14.59 74 55177 110154 42455930
Cross sensitivity reaction 20.16 14.59 17 55234 1658 42564426
Perseveration 20.09 14.59 7 55244 108 42565976
Infection 20.08 14.59 76 55175 111992 42454092
Chronic kidney disease 20.02 14.59 19 55232 47222 42518862
Psychiatric symptom 19.90 14.59 26 55225 4215 42561869
Pneumonitis 19.86 14.59 15 55236 41703 42524381
Behaviour disorder 19.80 14.59 34 55217 7020 42559064
Gastric infection 19.52 14.59 16 55235 1500 42564584
Diet refusal 19.36 14.59 9 55242 302 42565782
Eczema 19.34 14.59 10 55241 34076 42532008
Olfactory nerve disorder 19.24 14.59 6 55245 64 42566020
Antisocial behaviour 19.23 14.59 10 55241 429 42565655
Parkinsonian gait 19.23 14.59 11 55240 571 42565513
Nephrolithiasis 19.18 14.59 12 55239 36818 42529266
Miosis 19.09 14.59 49 55202 13397 42552687
Upper respiratory tract infection 19.02 14.59 16 55235 42157 42523927
Gastrointestinal haemorrhage 19.02 14.59 64 55187 97662 42468422
Floppy iris syndrome 19.00 14.59 9 55242 315 42565769
Heart rate decreased 18.90 14.59 12 55239 36520 42529564
Resuscitation 18.89 14.59 17 55234 1808 42564276
Cataract 18.87 14.59 8 55243 30596 42535488
Delusional disorder, unspecified type 18.68 14.59 12 55239 769 42565315
Urinary incontinence 18.49 14.59 66 55185 21602 42544482
Epilepsy 18.44 14.59 75 55176 26096 42539988
Pulmonary hypertension 18.43 14.59 4 55247 23565 42542519
Anaphylactic shock 18.37 14.59 4 55247 23513 42542571
Incorrect route of product administration 18.21 14.59 71 55180 24234 42541850
Full blood count abnormal 18.12 14.59 8 55243 29868 42536216
Anxiety 18.12 14.59 234 55017 118326 42447758
Speech sound disorder 18.10 14.59 7 55244 147 42565937
Akinesia 18.02 14.59 19 55232 2453 42563631
Hypersexuality 17.91 14.59 16 55235 1686 42564398
Rabbit syndrome 17.66 14.59 5 55246 37 42566047
Pancreatitis 17.64 14.59 18 55233 43250 42522834
Abdominal distension 17.63 14.59 42 55209 71693 42494391
Osteoarthritis 17.42 14.59 5 55246 24400 42541684
Nuchal rigidity 17.36 14.59 10 55241 526 42565558
Physical assault 17.35 14.59 13 55238 1069 42565015
Disease progression 17.33 14.59 112 55139 143544 42422540
Swelling 17.05 14.59 28 55223 54857 42511227
Oropharyngeal pain 16.98 14.59 18 55233 42492 42523592
Gastrooesophageal reflux disease 16.96 14.59 20 55231 45003 42521081
Therapy interrupted 16.95 14.59 4 55247 22246 42543838
Mumps 16.91 14.59 6 55245 98 42565986
Pica 16.89 14.59 5 55246 44 42566040
Gender dysphoria 16.89 14.59 5 55246 44 42566040
Staring 16.89 14.59 15 55236 1568 42564516
Localised infection 16.89 14.59 3 55248 20370 42545714
Unresponsive to stimuli 16.85 14.59 83 55168 31320 42534764
Unevaluable event 16.75 14.59 12 55239 34276 42531808
Brain injury 16.58 14.59 33 55218 7622 42558462
Negativism 16.57 14.59 9 55242 422 42565662
Sepsis 16.46 14.59 172 55079 199162 42366922
Blood insulin abnormal 16.39 14.59 4 55247 15 42566069
Malaise 16.35 14.59 186 55065 211970 42354114
Intensive care 16.21 14.59 13 55238 1181 42564903
Skin exfoliation 16.15 14.59 18 55233 41535 42524549
Cerebrovascular stenosis 16.07 14.59 6 55245 114 42565970
Posture abnormal 15.98 14.59 18 55233 2503 42563581
Osmotic demyelination syndrome 15.87 14.59 12 55239 1000 42565084
Haematuria 15.72 14.59 32 55219 57767 42508317
Cyanosis 15.68 14.59 49 55202 14982 42551102
Syncope 15.57 14.59 71 55180 99335 42466749
Hypophosphataemia 15.50 14.59 4 55247 20941 42545143
Incontinence 15.47 14.59 30 55221 6800 42559284
Flight of ideas 15.46 14.59 8 55243 340 42565744
Skin discolouration 15.44 14.59 4 55247 20886 42545198
Productive cough 15.38 14.59 27 55224 51540 42514544
Muscular weakness 15.36 14.59 56 55195 83442 42482642
Slow speech 15.32 14.59 15 55236 1775 42564309
Foetal arrhythmia 15.21 14.59 6 55245 133 42565951
Appendicitis 15.13 14.59 4 55247 20609 42545475
Antisocial personality disorder 15.07 14.59 5 55246 66 42566018
Accidental exposure to product by child 15.06 14.59 14 55237 1553 42564531
Photopsia 15.03 14.59 17 55234 2375 42563709
Transient ischaemic attack 14.97 14.59 13 55238 33726 42532358
Compulsions 14.94 14.59 7 55244 239 42565845
Bradycardia 14.91 14.59 173 55078 85311 42480773
Kleefstra syndrome 14.87 14.59 3 55248 3 42566081
Rash pruritic 14.85 14.59 13 55238 33590 42532494
Diplopia 14.80 14.59 4 55247 20312 42545772
Bacteraemia 14.73 14.59 7 55244 25033 42541051
Injection site erythema 14.67 14.59 4 55247 20191 42545893
Dyspnoea paroxysmal nocturnal 14.66 14.59 14 55237 1606 42564478
Neuropathy peripheral 14.65 14.59 75 55176 101778 42464306
Bacterial infection 14.64 14.59 9 55242 27870 42538214
Vasculitis 14.63 14.59 3 55248 18391 42547693
Mydriasis 14.62 14.59 34 55217 8736 42557348
Echolalia 14.62 14.59 8 55243 381 42565703
Illness 14.62 14.59 7 55244 24923 42541161

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 4426.49 15.01 1459 84658 32600 110470582
Extrapyramidal disorder 3306.64 15.01 1125 84992 27742 110475440
Dystonia 1262.17 15.01 541 85576 25264 110477918
Catatonia 1056.72 15.01 379 85738 10921 110492261
Akathisia 1033.16 15.01 417 85700 16696 110486486
Intentional self-injury 991.64 15.01 514 85603 36915 110466267
Muscle rigidity 921.89 15.01 425 85692 23606 110479576
Drug interaction 830.91 15.01 1434 84683 498749 110004433
Agitation 729.38 15.01 645 85472 112406 110390776
Psychotic disorder 656.96 15.01 439 85678 50498 110452684
Hallucination, auditory 652.04 15.01 346 85771 26051 110477131
Delusion 634.17 15.01 328 85789 23427 110479755
Sedation 632.64 15.01 485 85632 69198 110433984
Parkinsonism 620.20 15.01 316 85801 21871 110481311
Salivary hypersecretion 618.22 15.01 292 85825 17129 110486053
Tardive dyskinesia 615.77 15.01 270 85847 13309 110489873
Hyperprolactinaemia 608.93 15.01 219 85898 6356 110496826
Aggression 541.58 15.01 414 85703 58796 110444386
Delirium 523.78 15.01 584 85533 134441 110368741
Sopor 520.01 15.01 335 85782 36211 110466971
Electrocardiogram QT prolonged 481.64 15.01 505 85612 108455 110394727
Toxicity to various agents 405.00 15.01 1045 85072 479510 110023672
Psychomotor hyperactivity 404.84 15.01 231 85886 20046 110483136
Blood creatine phosphokinase increased 397.15 15.01 379 85738 72698 110430484
Arthralgia 396.36 15.01 66 86051 779566 109723616
Dyskinesia 377.15 15.01 316 85801 51130 110452052
Somnolence 364.40 15.01 750 85367 296699 110206483
Rhabdomyolysis 358.23 15.01 455 85662 119946 110383236
Treatment noncompliance 336.28 15.01 346 85771 72644 110430538
Suicide attempt 330.39 15.01 405 85712 102989 110400193
Schizophrenia 330.16 15.01 208 85909 21618 110481564
Weight increased 327.33 15.01 887 85230 418757 110084425
Tremor 312.69 15.01 563 85554 201669 110301513
Tachycardia 301.96 15.01 592 85525 226053 110277129
Pneumonia aspiration 298.87 15.01 342 85775 80891 110422291
Pain 294.80 15.01 191 85926 954764 109548418
Hypothermia 281.00 15.01 202 85915 26100 110477082
Hallucination 273.14 15.01 365 85752 101067 110402115
Joint swelling 262.91 15.01 22 86095 442823 110060359
Restlessness 259.68 15.01 267 85850 55992 110447190
Hyperthermia 254.28 15.01 175 85942 21097 110482085
Infusion related reaction 253.39 15.01 10 86107 381152 110122030
Headache 253.03 15.01 191 85926 882186 109620996
Rash 252.13 15.01 165 85952 820799 109682383
Cogwheel rigidity 247.08 15.01 97 86020 3601 110499581
Depressed level of consciousness 235.94 15.01 359 85758 111919 110391263
Torsade de pointes 233.29 15.01 170 85947 22430 110480752
Intentional overdose 229.57 15.01 388 85729 132113 110371069
Serotonin syndrome 227.69 15.01 255 85862 58898 110444284
Fatigue 224.59 15.01 377 85740 1215581 109287601
Altered state of consciousness 219.38 15.01 247 85870 57379 110445803
Coma 210.64 15.01 350 85767 117519 110385663
Mental impairment 208.44 15.01 159 85958 22480 110480702
Nasopharyngitis 205.45 15.01 31 86086 394330 110108852
Bradykinesia 204.92 15.01 119 85998 10669 110492513
Abnormal behaviour 203.58 15.01 198 85919 38841 110464341
Rheumatoid arthritis 202.06 15.01 7 86110 299606 110203576
Pain in extremity 202.01 15.01 64 86053 487054 110016128
Emotional poverty 199.15 15.01 60 86057 980 110502202
Hypertonia 198.56 15.01 107 86010 8299 110494883
Delusion of grandeur 197.01 15.01 72 86045 2188 110500994
Malignant catatonia 194.28 15.01 54 86063 652 110502530
Dysarthria 193.97 15.01 281 85836 83840 110419342
Priapism 188.94 15.01 92 86025 5769 110497413
Embolism venous 186.83 15.01 87 86030 4936 110498246
Overdose 185.77 15.01 498 85619 233296 110269886
Suicidal ideation 185.63 15.01 292 85825 93645 110409537
Myocarditis 184.69 15.01 167 85950 29888 110473294
Psychotic symptom 182.15 15.01 79 86038 3788 110499394
Sinusitis 180.90 15.01 13 86104 296675 110206507
Swelling 179.65 15.01 29 86088 351012 110152170
Abdominal discomfort 179.63 15.01 43 86074 393815 110109367
Oculogyric crisis 179.57 15.01 78 86039 3754 110499428
Pruritus 179.54 15.01 116 86001 581444 109921738
Systemic lupus erythematosus 178.67 15.01 4 86113 254334 110248848
Dysphagia 178.10 15.01 379 85738 153221 110349961
Ileus paralytic 177.86 15.01 112 86005 11625 110491557
Arthropathy 171.34 15.01 14 86103 287508 110215674
Drug abuse 170.24 15.01 406 85711 177005 110326177
Peripheral swelling 165.85 15.01 54 86063 403980 110099202
Mania 165.44 15.01 134 85983 20662 110482520
Torticollis 162.24 15.01 69 86048 3152 110500030
Persecutory delusion 159.65 15.01 84 86033 6207 110496975
Disorientation 157.02 15.01 232 85885 70439 110432743
Urticaria 153.07 15.01 31 86086 318826 110184356
Paranoia 150.78 15.01 131 85986 22243 110480939
Antipsychotic drug level below therapeutic 150.22 15.01 55 86062 1680 110501502
Dyspnoea 145.52 15.01 414 85703 1106458 109396724
Myoclonus 143.98 15.01 152 85965 32846 110470336
Psychomotor retardation 142.84 15.01 84 86033 7708 110495474
Wound 140.83 15.01 11 86106 234426 110268756
Hyperreflexia 139.95 15.01 89 86028 9396 110493786
Dizziness 139.41 15.01 205 85912 697988 109805194
Hypersensitivity 138.25 15.01 71 86046 403927 110099255
Drooling 136.26 15.01 79 86038 7060 110496122
Mutism 134.98 15.01 60 86057 3053 110500129
Intentional product misuse 131.64 15.01 308 85809 132596 110370586
Impaired healing 131.20 15.01 5 86112 196712 110306470
Disinhibition 128.22 15.01 58 86059 3076 110500106
Schizoaffective disorder 128.18 15.01 58 86059 3078 110500104
Obsessive-compulsive disorder 127.35 15.01 76 86041 7165 110496017
Asthma 125.09 15.01 22 86095 250269 110252913
Diarrhoea 122.91 15.01 465 85652 1139040 109364142
Leukocytosis 121.43 15.01 178 85939 53650 110449532
Neutrophil count increased 120.86 15.01 142 85975 34510 110468672
Urinary retention 120.55 15.01 204 85913 69479 110433703
Cognitive disorder 120.52 15.01 232 85885 87279 110415903
Social avoidant behaviour 120.31 15.01 66 86051 5303 110497879
Irritability 119.48 15.01 166 85951 47643 110455539
Oromandibular dystonia 118.13 15.01 42 86075 1177 110502005
Osteoarthritis 117.33 15.01 6 86111 182617 110320565
Cardiac arrest 116.87 15.01 378 85739 196375 110306807
Leukopenia 116.14 15.01 315 85802 148476 110354706
Contraindicated product administered 115.33 15.01 26 86091 248241 110254941
Drug level increased 115.25 15.01 163 85954 47556 110455626
Alopecia 114.87 15.01 71 86046 364682 110138500
Nausea 114.27 15.01 535 85582 1235155 109268027
Hyponatraemia 112.41 15.01 399 85718 217254 110285928
Musculoskeletal pain 111.59 15.01 8 86109 183015 110320167
Confusional state 110.59 15.01 683 85434 467997 110035185
Autonomic nervous system imbalance 110.42 15.01 64 86053 5716 110497466
Stomatitis 109.30 15.01 37 86080 270205 110232977
Arthritis 109.28 15.01 5 86112 167581 110335601
Euphoric mood 108.75 15.01 74 86043 8753 110494429
Mental status changes 106.29 15.01 203 85914 75919 110427263
Folliculitis 106.16 15.01 6 86111 167647 110335535
Stupor 105.92 15.01 71 86046 8194 110494988
Spasmodic dysphonia 105.07 15.01 32 86085 543 110502639
Hypoaesthesia 104.85 15.01 57 86060 314166 110189016
Cardio-respiratory arrest 104.55 15.01 259 85858 115577 110387605
Abdominal pain upper 104.43 15.01 72 86045 349039 110154143
Asthenia 103.97 15.01 240 85877 688759 109814423
Back pain 103.88 15.01 82 86035 370914 110132268
Bradyphrenia 100.61 15.01 79 86038 11649 110491533
Wheezing 99.70 15.01 37 86080 255193 110247989
Lymphocyte count abnormal 99.57 15.01 45 86072 2381 110500801
Affective disorder 99.21 15.01 77 86040 11164 110492018
Seizure 98.80 15.01 387 85730 220798 110282384
Paraesthesia 98.49 15.01 46 86071 276475 110226707
Blood prolactin increased 98.36 15.01 55 86062 4587 110498595
Drug intolerance 98.18 15.01 103 86014 406409 110096773
Ill-defined disorder 98.14 15.01 6 86111 156847 110346335
Cough 94.54 15.01 133 85984 461508 110041674
Discomfort 91.08 15.01 27 86090 214680 110288502
Completed suicide 90.95 15.01 402 85715 241979 110261203
Hepatic enzyme increased 89.73 15.01 71 86046 320821 110182361
Antipsychotic drug level increased 89.27 15.01 60 86057 6955 110496227
Inappropriate antidiuretic hormone secretion 88.29 15.01 120 85997 33731 110469451
Speech disorder 88.19 15.01 166 85951 61403 110441779
Injection site pain 88.10 15.01 16 86101 177906 110325276
Bursitis 87.67 15.01 3 86114 129915 110373267
C-reactive protein abnormal 87.50 15.01 3 86114 129692 110373490
Night sweats 87.35 15.01 4 86113 133979 110369203
Galactorrhoea 84.70 15.01 48 86069 4107 110499075
Inflammation 84.37 15.01 23 86094 193215 110309967
Bradycardia 83.64 15.01 289 85828 155228 110347954
Encephalitis autoimmune 83.58 15.01 45 86072 3483 110499699
Paroxysmal perceptual alteration 83.57 15.01 23 86094 267 110502915
Withdrawal syndrome 82.99 15.01 112 86005 31268 110471914
Therapeutic product effect variable 82.64 15.01 41 86076 2677 110500505
Refusal of examination 82.38 15.01 22 86095 226 110502956
Lethargy 82.09 15.01 207 85910 93369 110409813
Sluggishness 80.54 15.01 58 86059 7509 110495673
Protrusion tongue 80.04 15.01 25 86092 463 110502719
Product dose omission issue 79.41 15.01 80 86037 321702 110181480
Rhinalgia 79.05 15.01 45 86072 3884 110499298
Negativism 78.77 15.01 29 86088 900 110502282
Waxy flexibility 78.23 15.01 22 86095 278 110502904
Mobility decreased 77.84 15.01 44 86073 237378 110265804
Polydipsia 77.45 15.01 57 86060 7631 110495551
Drug withdrawal syndrome 76.12 15.01 119 85998 37935 110465247
Unresponsive to stimuli 75.73 15.01 159 85958 63631 110439551
Increased appetite 74.41 15.01 74 86043 14903 110488279
Drug ineffective 73.65 15.01 1622 84495 1518918 108984264
Faecaloma 72.85 15.01 73 86044 14835 110488347
Contusion 72.63 15.01 46 86071 233315 110269867
Pericarditis 71.26 15.01 41 86076 219073 110284109
Psychosexual disorder 70.88 15.01 18 86099 149 110503033
Mental disorder 70.33 15.01 116 86001 38675 110464507
Behaviour disorder 70.13 15.01 59 86058 9588 110493594
Therapeutic product effect decreased 69.62 15.01 53 86064 244263 110258919
Infection 67.71 15.01 111 86006 362089 110141093
Lower respiratory tract infection 67.68 15.01 54 86063 243052 110260130
Refusal of treatment by patient 66.83 15.01 57 86060 9437 110493745
White blood cell count increased 66.71 15.01 196 85921 96646 110406536
Intestinal pseudo-obstruction 66.35 15.01 38 86079 3318 110499864
Disturbance in attention 66.14 15.01 148 85969 61847 110441335
Chest pain 66.10 15.01 120 85997 376255 110126927
Injury 65.44 15.01 28 86089 177237 110325945
Echolalia 65.05 15.01 22 86095 529 110502653
Pulmonary embolism 64.66 15.01 334 85783 214140 110289042
Gastrointestinal disorder 64.57 15.01 56 86061 241896 110261286
Influenza 63.57 15.01 26 86091 169075 110334107
Pulmonary fibrosis 63.54 15.01 4 86113 102038 110401144
Chest discomfort 63.32 15.01 28 86089 173820 110329362
Herpes zoster 62.57 15.01 6 86111 108373 110394809
Gastrooesophageal reflux disease 62.45 15.01 31 86086 179945 110323237
Psoriasis 62.36 15.01 16 86101 139977 110363205
Self-injurious ideation 62.18 15.01 40 86077 4306 110498876
Stereotypy 62.10 15.01 25 86092 992 110502190
Hallucination, visual 62.04 15.01 111 86006 39494 110463688
Oedema 61.84 15.01 44 86073 209932 110293250
Granulocytopenia 61.65 15.01 62 86055 12653 110490529
Encephalopathy 61.62 15.01 170 85947 80885 110422297
Tachypnoea 61.18 15.01 110 86007 39285 110463897
Hallucinations, mixed 60.80 15.01 52 86065 8641 110494541
Blood cholesterol increased 59.48 15.01 35 86082 184750 110318432
Miosis 58.96 15.01 79 86038 21904 110481278
Visceral congestion 58.56 15.01 26 86091 1319 110501863
Resting tremor 58.42 15.01 28 86089 1695 110501487
Liver injury 58.39 15.01 22 86095 150391 110352791
Generalised tonic-clonic seizure 57.72 15.01 130 85987 54550 110448632
Bronchitis 57.65 15.01 25 86092 157007 110346175
Opisthotonus 57.42 15.01 22 86095 764 110502418
Sudden death 56.94 15.01 82 86035 24313 110478869
Hyperammonaemic encephalopathy 56.35 15.01 41 86076 5393 110497789
Rebound effect 55.53 15.01 63 86054 14743 110488439
Lung disorder 55.32 15.01 36 86081 180011 110323171
Oropharyngeal spasm 55.26 15.01 19 86098 481 110502701
Myelosuppression 55.05 15.01 5 86112 94335 110408847
Erythema 54.75 15.01 89 86028 291358 110211824
Nephrogenic diabetes insipidus 54.63 15.01 30 86087 2415 110500767
Thinking abnormal 54.39 15.01 63 86054 15077 110488105
Substance-induced psychotic disorder 54.16 15.01 40 86077 5384 110497798
Hypernatraemia 52.35 15.01 67 86050 17766 110485416
Malaise 52.25 15.01 308 85809 671511 109831671
Wound infection 51.53 15.01 7 86110 96458 110406724
Respiratory failure 51.42 15.01 315 85802 215017 110288165
Choking 51.16 15.01 61 86056 15049 110488133
Intentional product use issue 51.12 15.01 71 86046 247835 110255347
Clonus 50.75 15.01 47 86070 8669 110494513
Migraine 50.50 15.01 36 86081 171616 110331566
Neutropenia 50.46 15.01 479 85638 374141 110129041
Drug hypersensitivity 50.23 15.01 183 85934 453907 110049275
Oscillopsia 50.02 15.01 17 86100 415 110502767
Blunted affect 49.85 15.01 18 86099 528 110502654
Electrocardiogram J wave 48.89 15.01 12 86105 85 110503097
Myocardial reperfusion injury 48.81 15.01 13 86104 132 110503050
Type 2 diabetes mellitus 48.53 15.01 40 86077 177192 110325990
Dyslipidaemia 48.47 15.01 61 86056 15904 110487278
Weight decreased 48.31 15.01 194 85923 467863 110035319
Colitis ulcerative 48.26 15.01 3 86114 77360 110425822
Eye movement disorder 48.21 15.01 48 86069 9680 110493502
Nuchal rigidity 47.88 15.01 22 86095 1210 110501972
Sexual dysfunction 47.74 15.01 45 86072 8485 110494697
Muscular weakness 47.49 15.01 75 86042 248393 110254789
Trismus 47.25 15.01 40 86077 6556 110496626
Blood prolactin abnormal 46.89 15.01 32 86085 3803 110499379
Apraxia 46.78 15.01 31 86086 3509 110499673
Hyperhidrosis 46.63 15.01 277 85840 187021 110316161
Colitis ischaemic 46.40 15.01 63 86054 17687 110485495
Hyperthermia malignant 46.40 15.01 32 86085 3868 110499314
Nasal congestion 46.21 15.01 10 86107 98272 110404910
Reduced facial expression 45.91 15.01 31 86086 3620 110499562
Fluid retention 45.57 15.01 9 86108 94298 110408884
Injection site erythema 45.48 15.01 9 86108 94167 110409015
Cardiac failure congestive 45.30 15.01 31 86086 150969 110352213
Anaemia 45.12 15.01 246 85871 546840 109956342
Oedema peripheral 44.39 15.01 121 85996 328539 110174643
Chorea 44.38 15.01 29 86088 3206 110499976
Product packaging issue 44.36 15.01 23 86094 1648 110501534
Injection site reaction 44.10 15.01 8 86109 89062 110414120
Febrile neutropenia 44.01 15.01 115 86002 316652 110186530
Lower limb fracture 43.95 15.01 4 86113 75344 110427838
Encephalitis toxic 43.63 15.01 14 86103 284 110502898
Feeling guilty 43.49 15.01 19 86098 927 110502255
Blister 43.10 15.01 69 86048 227307 110275875
Apathy 43 15.01 58 86059 16181 110487001
Coma scale abnormal 42.77 15.01 45 86072 9681 110493501
Toxic epidermal necrolysis 42.15 15.01 118 85999 56609 110446573
Neurotoxicity 41.96 15.01 98 86019 42109 110461073
Huntington's disease 41.95 15.01 8 86109 12 110503170
Brain injury 41.73 15.01 52 86065 13424 110489758
Epistaxis 41.52 15.01 25 86092 130347 110372835
Dry mouth 41.48 15.01 57 86060 199891 110303291
Bruxism 41.46 15.01 33 86084 4961 110498221
Dry skin 41.36 15.01 16 86101 107637 110395545
Poisoning 41.08 15.01 78 86039 29027 110474155
Sinus tachycardia 40.67 15.01 100 86017 44393 110458789
Hyperventilation 40.43 15.01 42 86075 8905 110494277
Rapid eye movement sleep behaviour disorder 40.03 15.01 16 86101 623 110502559
Tic 40.01 15.01 28 86089 3465 110499717
Road traffic accident 39.57 15.01 17 86100 107381 110395801
Respiratory alkalosis 39.56 15.01 34 86083 5687 110497495
Psychiatric decompensation 39.33 15.01 34 86083 5731 110497451
Sexually inappropriate behaviour 39.27 15.01 16 86101 655 110502527
Impulsive behaviour 38.97 15.01 27 86090 3288 110499894
Tension 38.87 15.01 32 86085 5046 110498136
Blood pressure increased 38.87 15.01 90 86027 258283 110244899
Osteoporosis 38.74 15.01 10 86107 87142 110416040
Hypersexuality 38.44 15.01 22 86095 1918 110501264
Patient restraint 38.24 15.01 10 86107 94 110503088
Grandiosity 38.02 15.01 15 86102 564 110502618
Muscle spasms 37.12 15.01 103 86014 278054 110225128
Anticholinergic syndrome 37.08 15.01 29 86088 4251 110498931
Haematochezia 37.00 15.01 22 86095 115502 110387680
Drug ineffective for unapproved indication 36.60 15.01 168 85949 102670 110400512
Hyperammonaemia 36.29 15.01 49 86068 13683 110489499
Eosinophil count decreased 36.10 15.01 33 86084 5985 110497197
Oral discharge 36.07 15.01 12 86105 274 110502908
Compulsive sexual behaviour 35.78 15.01 12 86105 281 110502901
Gestational diabetes 35.77 15.01 36 86081 7353 110495829
Pyramidal tract syndrome 35.68 15.01 16 86101 831 110502351
Sinus bradycardia 35.58 15.01 74 86043 29409 110473773
Parotitis 35.47 15.01 25 86092 3128 110500054
Illness 35.44 15.01 10 86107 82161 110421021
Diet refusal 35.38 15.01 16 86101 848 110502334
Illogical thinking 35.17 15.01 9 86108 77 110503105
Differential white blood cell count abnormal 35.12 15.01 22 86095 2262 110500920
Parkinsonian gait 35.07 15.01 17 86100 1055 110502127
Wrong patient received product 35.06 15.01 34 86083 6640 110496542
Red blood cell sedimentation rate increased 34.77 15.01 9 86108 78293 110424889
Akinesia 34.29 15.01 26 86091 3641 110499541
Psychiatric symptom 34.21 15.01 39 86078 9174 110494008
Posturing 34.19 15.01 17 86100 1115 110502067
Haemoglobin urine 34.04 15.01 10 86107 149 110503033
Cataract 33.68 15.01 10 86107 79475 110423707
Floppy iris syndrome 33.56 15.01 12 86105 342 110502840
Hyporesponsive to stimuli 32.93 15.01 23 86094 2837 110500345
Somatic symptom disorder of pregnancy 32.82 15.01 9 86108 103 110503079
Interstitial lung disease 32.82 15.01 36 86081 139298 110363884
Penis disorder 32.69 15.01 16 86101 1014 110502168
Burning sensation 32.62 15.01 7 86110 69205 110433977
Peptostreptococcus infection 32.60 15.01 10 86107 174 110503008
Respiratory depression 32.57 15.01 75 86042 31926 110471256
Metabolic syndrome 32.54 15.01 24 86093 3223 110499959
Rash pruritic 32.37 15.01 18 86099 98051 110405131
Tonic clonic movements 32.27 15.01 23 86094 2929 110500253
Drug resistance 32.25 15.01 107 86010 56267 110446915
Distractibility 31.64 15.01 15 86102 886 110502296
Cerebrovascular accident 31.62 15.01 58 86059 181226 110321956
Maternal exposure during pregnancy 31.38 15.01 98 86019 254785 110248397
Antipsychotic drug level above therapeutic 31.36 15.01 21 86096 2419 110500763
Head titubation 31.29 15.01 17 86100 1340 110501842
Slow speech 31.26 15.01 24 86093 3424 110499758
Decreased appetite 30.98 15.01 230 85887 475616 110027566
Water intoxication 30.75 15.01 15 86102 944 110502238
Staring 30.40 15.01 22 86095 2870 110500312
Flight of ideas 29.93 15.01 14 86103 802 110502380
Muscle contractions involuntary 29.90 15.01 26 86091 4418 110498764
Cannabinoid hyperemesis syndrome 29.88 15.01 8 86109 83 110503099
Upper respiratory tract infection 29.77 15.01 35 86082 131293 110371889
Hepatocellular injury 29.76 15.01 97 86020 50545 110452637
Electroencephalogram abnormal 29.75 15.01 30 86087 6143 110497039
Intestinal obstruction 29.54 15.01 100 86017 53127 110450055
Urinary incontinence 29.40 15.01 94 86023 48493 110454689
Self-destructive behaviour 29.31 15.01 14 86103 841 110502341
Dementia with Lewy bodies 29.25 15.01 15 86102 1051 110502131
Acute psychosis 29.24 15.01 27 86090 4960 110498222
Sedation complication 29.01 15.01 54 86063 19801 110483381
Delusional disorder, unspecified type 28.76 15.01 14 86103 877 110502305
Speech sound disorder 28.72 15.01 7 86110 48 110503134
Stress 28.56 15.01 24 86093 105324 110397858
Mydriasis 28.38 15.01 57 86060 22100 110481082
Throat irritation 28.33 15.01 4 86113 53548 110449634
Hemianopia 28.30 15.01 21 86096 2847 110500335
Drug diversion 28.29 15.01 16 86101 1364 110501818
Flushing 28.22 15.01 24 86093 104712 110398470
Neglect of personal appearance 28.15 15.01 11 86106 403 110502779
Dyspnoea exertional 27.85 15.01 24 86093 104036 110399146
Illusion 27.55 15.01 18 86099 1989 110501193
Agranulocytosis 27.49 15.01 108 86009 61652 110441530
Schizoaffective disorder bipolar type 27.45 15.01 10 86107 301 110502881
Loss of consciousness 27.39 15.01 253 85864 196053 110307129
Eczema 27.35 15.01 11 86106 72282 110430900
Hypoxic-ischaemic encephalopathy 27.17 15.01 34 86083 8813 110494369
Communication disorder 27.09 15.01 26 86091 5013 110498169
Poor personal hygiene 27.06 15.01 12 86105 607 110502575
Myalgia 27.02 15.01 86 86031 222295 110280887
Negative symptoms in schizophrenia 26.83 15.01 9 86108 211 110502971
Postoperative respiratory failure 26.63 15.01 9 86108 216 110502966
Megacolon 26.60 15.01 24 86093 4281 110498901
Somatic hallucination 26.56 15.01 7 86110 68 110503114
Muscle contracture 26.46 15.01 20 86097 2788 110500394
Pneumonia 26.24 15.01 503 85614 876211 109626971
Granulomatous liver disease 26.24 15.01 16 86101 1568 110501614
Liver disorder 26.17 15.01 44 86073 142199 110360983
Pressure of speech 26.11 15.01 15 86102 1317 110501865
Cholinergic syndrome 26.11 15.01 15 86102 1317 110501865
Treatment failure 26.06 15.01 119 85998 277115 110226067
Symptom masked 26.03 15.01 17 86100 1878 110501304
Intestinal dilatation 26.02 15.01 22 86095 3598 110499584
SARS-CoV-2 test positive 25.93 15.01 47 86070 16888 110486294
Apallic syndrome 25.90 15.01 14 86103 1092 110502090
Injection site swelling 25.77 15.01 8 86109 61782 110441400
Vulvovaginal candidiasis 25.77 15.01 21 86096 3264 110499918
Myocardial infarction 25.71 15.01 71 86046 192012 110311170
Feeling hot 25.64 15.01 20 86097 91086 110412096
HIV peripheral neuropathy 25.60 15.01 6 86111 34 110503148
Dry eye 25.58 15.01 6 86111 55787 110447395
Blepharospasm 24.94 15.01 6 86111 54845 110448337
Compulsions 24.53 15.01 10 86107 410 110502772
Pregnancy 24.41 15.01 5 86112 51062 110452120
Hallucination, olfactory 24.32 15.01 11 86106 583 110502599
Blood pressure fluctuation 24.31 15.01 14 86103 74810 110428372
Hypercholesterolaemia 24.25 15.01 21 86096 90816 110412366
Accidental exposure to product by child 24.16 15.01 20 86097 3178 110500004
Olfactory nerve disorder 24.15 15.01 6 86111 45 110503137
Live birth 24.05 15.01 12 86105 69472 110433710
Eosinophilia 23.94 15.01 99 86018 57837 110445345
Multiple sclerosis relapse 23.84 15.01 5 86112 50235 110452947
Neck pain 23.67 15.01 37 86080 123093 110380089
Dementia 23.64 15.01 66 86051 31607 110471575
Haemorrhage 23.58 15.01 29 86088 106663 110396519
Resuscitation 23.54 15.01 19 86098 2914 110500268
Circadian rhythm sleep disorder 23.53 15.01 13 86104 1059 110502123
Eosinophil count abnormal 23.51 15.01 13 86104 1061 110502121
Anaphylactic reaction 23.28 15.01 33 86084 114267 110388915
Cardiomyopathy alcoholic 23.28 15.01 6 86111 53 110503129
Grimacing 23.17 15.01 12 86105 858 110502324
Aspiration 23.16 15.01 64 86053 30469 110472713
Hypokinesia 23.15 15.01 52 86065 21774 110481408
Impaired gastric emptying 23.13 15.01 39 86078 13236 110489946
Red blood cells urine 23.09 15.01 11 86106 657 110502525
Gaze palsy 23.06 15.01 20 86097 3387 110499795
Brain death 23.02 15.01 27 86090 6546 110496636
Drop attacks 22.91 15.01 13 86104 1115 110502067
Cytomegalovirus infection 22.80 15.01 7 86110 54437 110448745
Hostility 22.78 15.01 18 86099 2678 110500504
Patient elopement 22.70 15.01 9 86108 343 110502839
Psychotic behaviour 22.60 15.01 14 86103 1411 110501771
Haemodynamic instability 22.59 15.01 53 86064 22835 110480347
Gait inability 22.58 15.01 45 86072 136331 110366851
Coronary artery disease 22.47 15.01 14 86103 71676 110431506
Diverticulitis 22.20 15.01 7 86110 53515 110449667
Oropharyngeal pain 22.09 15.01 45 86072 135231 110367951
Abdominal pain 21.88 15.01 275 85842 512714 109990468
Delusion of reference 21.77 15.01 8 86109 247 110502935
Electrocardiogram PR prolongation 21.64 15.01 15 86102 1828 110501354
Lactate pyruvate ratio increased 21.62 15.01 6 86111 72 110503110
Rhinorrhoea 21.55 15.01 29 86088 102637 110400545
Ventricular fibrillation 21.52 15.01 76 86041 41237 110461945
Psychomotor skills impaired 21.48 15.01 27 86090 7031 110496151
Lymphocyte count decreased 21.48 15.01 95 86022 57148 110446034
Ear infection 21.46 15.01 11 86106 62721 110440461
Blood phosphorus decreased 21.25 15.01 28 86089 7637 110495545
Wolff-Parkinson-White syndrome 21.24 15.01 9 86108 407 110502775
Inappropriate schedule of product administration 21.23 15.01 84 86033 203553 110299629
Palpitations 21.19 15.01 59 86058 159153 110344029
Blood pressure systolic increased 21.18 15.01 20 86097 82971 110420211
Poverty of speech 21.09 15.01 10 86107 591 110502591
Heart rate decreased 21.05 15.01 20 86097 82736 110420446
Perseveration 21.02 15.01 9 86108 418 110502764
Physical assault 20.89 15.01 14 86103 1614 110501568
Memory impairment 20.69 15.01 81 86036 196863 110306319
Laryngitis 20.59 15.01 4 86113 42407 110460775
Basal cell carcinoma 20.49 15.01 5 86112 45265 110457917
Product quality issue 20.47 15.01 18 86099 77281 110425901
Full blood count abnormal 20.45 15.01 9 86108 56043 110447139
Screaming 20.43 15.01 22 86095 4859 110498323
Dyspepsia 20.41 15.01 78 86039 190887 110312295
Inappropriate affect 20.35 15.01 14 86103 1685 110501497
Dysphoria 20.22 15.01 25 86092 6403 110496779
Antipsychotic drug level decreased 20.21 15.01 13 86104 1399 110501783
Osmotic demyelination syndrome 20.12 15.01 15 86102 2048 110501134
Pancreatitis 20.07 15.01 26 86091 93507 110409675
Body temperature increased 19.92 15.01 90 86027 54623 110448559
Pituitary tumour benign 19.85 15.01 17 86100 2830 110500352
Nervous system disorder 19.77 15.01 62 86055 31659 110471523
Disorganised speech 19.60 15.01 18 86099 3285 110499897
Drug reaction with eosinophilia and systemic symptoms 19.51 15.01 120 85997 81975 110421207
Sleep disorder 19.43 15.01 84 86033 198560 110304622
Femoral neck fracture 19.39 15.01 35 86082 12532 110490650
Cyanosis 19.34 15.01 59 86058 29682 110473500
Abdominal distension 19.05 15.01 71 86046 175032 110328150
Localised infection 19.01 15.01 5 86112 43043 110460139
Movement disorder 18.99 15.01 67 86050 36337 110466845
Loss of personal independence in daily activities 18.94 15.01 57 86060 149963 110353219
Dysgeusia 18.90 15.01 16 86101 69969 110433213
Amenorrhoea 18.64 15.01 29 86088 9202 110493980
Blood citric acid increased 18.58 15.01 5 86112 53 110503129
Posture abnormal 18.57 15.01 20 86097 4418 110498764
Chills 18.39 15.01 81 86036 190499 110312683
Polyglandular disorder 18.38 15.01 7 86110 239 110502943
Tachyphrenia 18.35 15.01 15 86102 2341 110500841
Echopraxia 18.33 15.01 5 86112 56 110503126
Immunodeficiency 18.16 15.01 4 86113 38834 110464348
Nephrolithiasis 18.05 15.01 15 86102 66197 110436985
Procedural pain 18.03 15.01 3 86114 35562 110467620
Tongue spasm 17.95 15.01 6 86111 139 110503043
Accidental overdose 17.94 15.01 84 86033 51750 110451432
Antidepressant drug level increased 17.87 15.01 9 86108 607 110502575
Gender dysphoria 17.87 15.01 5 86112 62 110503120
Thrombosis 17.86 15.01 36 86081 108626 110394556
Exhibitionism 17.79 15.01 5 86112 63 110503119
Depressive symptom 17.79 15.01 27 86090 8387 110494795
False positive investigation result 17.77 15.01 12 86105 1402 110501780
Labile blood pressure 17.73 15.01 15 86102 2456 110500726
Skin discolouration 17.69 15.01 8 86109 49038 110454144
Dyspnoea paroxysmal nocturnal 17.57 15.01 15 86102 2487 110500695
Mucosal dryness 17.47 15.01 19 86098 4244 110498938
Antisocial personality disorder 17.37 15.01 5 86112 69 110503113
Product use issue 17.36 15.01 157 85960 311538 110191644
Limb injury 17.35 15.01 4 86113 37632 110465550
Cataplexy 17.32 15.01 11 86106 1158 110502024
Metabolic acidosis 17.32 15.01 135 85982 99609 110403573
Device issue 17.32 15.01 3 86114 34532 110468650
Haemoptysis 17.28 15.01 18 86099 71336 110431846
Impaired self-care 17.25 15.01 15 86102 2549 110500633
Ulcer 17.25 15.01 6 86111 43110 110460072
Fungal infection 17.24 15.01 9 86108 50797 110452385
Leukaemia 17.15 15.01 25 86092 7493 110495689
Eating disorder 17.14 15.01 58 86059 30800 110472382
Pneumocystis jirovecii pneumonia 17.00 15.01 6 86111 42729 110460453
Vascular dementia 16.99 15.01 10 86107 919 110502263
Hypoparathyroidism 16.91 15.01 12 86105 1518 110501664
Cerebrovascular stenosis 16.88 15.01 6 86111 168 110503014
Transient ischaemic attack 16.82 15.01 15 86102 63967 110439215
Scrotal haematoma 16.81 15.01 5 86112 78 110503104
Gastrointestinal haemorrhage 16.80 15.01 69 86048 165449 110337733
Logorrhoea 16.76 15.01 20 86097 4937 110498245
Myxoedema coma 16.76 15.01 9 86108 693 110502489
Hyperphagia 16.72 15.01 17 86100 3514 110499668
Paraphilia 16.63 15.01 5 86112 81 110503101
Urinary tract infection 16.62 15.01 168 85949 326114 110177068
Hypoxia 16.61 15.01 164 85953 129351 110373831
Anger 16.61 15.01 42 86075 18965 110484217
Incoherent 16.52 15.01 26 86091 8332 110494850
Duodenal stenosis 16.52 15.01 10 86107 967 110502215
Kleefstra syndrome 16.40 15.01 3 86114 3 110503179
Drug-induced liver injury 16.35 15.01 44 86073 120023 110383159
Hyperkinesia 16.31 15.01 16 86101 3168 110500014
Visual impairment 16.31 15.01 52 86065 134376 110368806
Eye swelling 16.29 15.01 3 86114 33045 110470137
Wrong product administered 16.25 15.01 30 86087 10930 110492252
Anaphylactic shock 16.25 15.01 10 86107 51536 110451646
Neutrophilia 16.24 15.01 29 86088 10300 110492882
Laboratory test abnormal 16.20 15.01 7 86110 44072 110459110
Self-medication 16.11 15.01 22 86095 6210 110496972
Pica 16.09 15.01 5 86112 91 110503091
Surgery 16.08 15.01 6 86111 41277 110461905
Soliloquy 16.06 15.01 10 86107 1017 110502165
Paradoxical drug reaction 16.00 15.01 28 86089 9789 110493393
Haematuria 15.90 15.01 25 86092 82980 110420202
Vascular stenosis 15.89 15.01 9 86108 769 110502413
Labelled drug-food interaction medication error 15.78 15.01 6 86111 204 110502978
Electroconvulsive therapy 15.74 15.01 5 86112 98 110503084
Drug screen false positive 15.74 15.01 11 86106 1358 110501824
Condition aggravated 15.72 15.01 711 85406 734125 109769057
Visual acuity reduced 15.69 15.01 3 86114 32170 110471012
Swelling face 15.68 15.01 30 86087 92291 110410891
Polyneuropathy 15.58 15.01 3 86114 32009 110471173
Pleurothotonus 15.58 15.01 14 86103 2484 110500698
Prostate cancer 15.47 15.01 5 86112 37636 110465546
Device dislocation 15.37 15.01 3 86114 31701 110471481
Borderline personality disorder 15.33 15.01 10 86107 1102 110502080
Therapy interrupted 15.24 15.01 10 86107 49812 110453370
Product use in unapproved indication 15.20 15.01 456 85661 446921 110056261
Blood insulin abnormal 15.07 15.01 4 86113 40 110503142
Fear 15.07 15.01 46 86071 23147 110480035
Therapy partial responder 15.05 15.01 63 86054 36998 110466184

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AD01 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Butyrophenone derivatives
MeSH PA D000932 Antiemetics
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014150 Antipsychotic Agents
MeSH PA D015259 Dopamine Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018492 Dopamine Antagonists
MeSH PA D018726 Anti-Dyskinesia Agents
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:48279 serotonergic antagonist
CHEBI has role CHEBI:48561 dopaminergic antagonist
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:65190 first generation antipsychotic
CHEBI has role CHEBI:66956 antidyskinesia agent
FDA EPC N0000180182 Typical Antipsychotic
CHEBI has role CHEBI:35476 antipsychotic agent

Related Drugs by ATC class:

N05AD Butyrophenone derivatives 8 drugs
benperidolbromperidoldroperidollumateperonemelperonemoperonepipamperonetrifluperidol

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Gilles de la Tourette's syndrome indication 5158005 DOID:11119
Schizophrenia indication 58214004 DOID:5419
Psychotic disorder indication 69322001
Chronic schizophrenia indication 83746006
Delirium off-label use 2776000
Nausea and vomiting off-label use 16932000
Pain off-label use 22253000
Anxiety disorder off-label use 197480006 DOID:2030
Headache disorder off-label use 230461009
Gastroparesis off-label use 235675006
Chemotherapy-induced nausea and vomiting off-label use 236084000
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Thyrotoxic crisis contraindication 29028009 DOID:12837
Torsades de pointes contraindication 31722008
Parkinsonism contraindication 32798002
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Extrapyramidal disease contraindication 76349003
Leukopenia contraindication 84828003 DOID:615
Tardive dyskinesia contraindication 102449007
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Hypomagnesemia contraindication 190855004
Angina pectoris contraindication 194828000
Disease of liver contraindication 235856003 DOID:409
Retention of urine contraindication 267064002
Neutropenic disorder contraindication 303011007 DOID:1227
Coma contraindication 371632003
Breastfeeding (mother) contraindication 413712001
Central nervous system depression contraindication 418072004
Acquired torsion dystonia contraindication 433493000
Congenital long QT syndrome contraindication 442917000
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002
Drug Induced CNS Depression contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.36 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
D(2) dopamine receptor GPCR INVERSE AGONIST Ki 9.15 WOMBAT-PK CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.30 PDSP
Mu-type opioid receptor GPCR Ki 6.00 DRUG MATRIX
D(1A) dopamine receptor GPCR Ki 7.82 WOMBAT-PK
Alpha-2A adrenergic receptor GPCR Ki 5.95 PDSP
Sigma non-opioid intracellular receptor 1 Membrane receptor EC50 8.92 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 7.50 WOMBAT-PK
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase Enzyme Ki 6.72 WOMBAT-PK
Multidrug resistance protein 1 Transporter Ki 6.70 WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 5.74 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 5.74 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Ki 5.55 CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 7 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 6.10 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR Ki 5.33 CHEMBL
5-hydroxytryptamine receptor 6 GPCR Ki 5.22 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 6.45 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 7.90 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 6.32 PDSP
D(3) dopamine receptor GPCR INVERSE AGONIST Ki 8.52 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 7.52 WOMBAT-PK
Histamine H1 receptor GPCR Ki 6.36 CHEMBL
Histamine H2 receptor GPCR Ki 6.00 PDSP
Muscarinic acetylcholine receptor M1 GPCR Ki 5.80 CHEMBL
Muscarinic acetylcholine receptor M3 GPCR Ki 5 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 6.18 PDSP
5-hydroxytryptamine receptor 1B GPCR Ki 6.57 PDSP
5-hydroxytryptamine receptor 1D GPCR ANTAGONIST Ki 6.60 IUPHAR
Alpha-2C adrenergic receptor GPCR Ki 6.26 PDSP
Alpha-1D adrenergic receptor GPCR Ki 7.55 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 8.10 PDSP
Calmodulin Cytosolic other IC50 6.30 WOMBAT-PK
5-hydroxytryptamine receptor 5A GPCR Ki 5.65 PDSP
5-hydroxytryptamine receptor 1F GPCR Ki 5.30 PDSP
Glutamate receptor ionotropic, NMDA 2B Ion channel Ki 7.89 CHEMBL
5-hydroxytryptamine receptor 1E GPCR Ki 5.30 PDSP
Potassium channel subfamily K member 2 Ion channel IC50 5.26 CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 5.92 CHEMBL
Histone H1.0 Nuclear other Ki 6.11 CHEMBL
Transmembrane protein 97 Enzyme Ki 7.80 CHEMBL
Potassium voltage-gated channel subfamily H member 1 Ion channel BLOCKER IC50 6.20 IUPHAR
D(4) dopamine receptor GPCR INVERSE AGONIST Kd 9.42 SCIENTIFIC LITERATURE
Alpha-1B adrenergic receptor GPCR Ki 8.31 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 7.44 DRUG MATRIX
Pol polyprotein Enzyme Ki 7 CHEMBL
Alpha-1A adrenergic receptor GPCR Kd 7.76 CHEMBL
Histamine H1 receptor GPCR Ki 6.40 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 6.62 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 5.74 CHEMBL
D(2) dopamine receptor GPCR Ki 9.70 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 6.40 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 7.35 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 9.05 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 6.58 CHEMBL
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 6.30 IUPHAR
D(1A) dopamine receptor GPCR Ki 7.70 CHEMBL
D(2) dopamine receptor GPCR Ki 9.52 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 7.70 CHEMBL
Histamine H1 receptor GPCR Ki 6.42 CHEMBL
D(3) dopamine receptor GPCR Ki 8.52 CHEMBL
Protease Enzyme Ki 7 CHEMBL
D(2) dopamine receptor GPCR Ki 8.32 CHEMBL
5-hydroxytryptamine receptor 2A GPCR IC50 7.52 CHEMBL
C-8 sterol isomerase Enzyme Ki 9.30 CHEMBL
D(1A) dopamine receptor GPCR Ki 7.03 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane other Ki 9.08 CHEMBL
Transporter Transporter Ki 5.26 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 7.52 CHEMBL
D(3) dopamine receptor GPCR Ki 8.52 CHEMBL
Vesicular acetylcholine transporter Transporter Ki 6.41 CHEMBL
AP-2 complex subunit sigma Cytosolic other Ki 7.62 CHEMBL
Muscarinic acetylcholine receptor GPCR Ki 5.13 CHEMBL
Opioid receptor GPCR Ki 5.92 CHEMBL
Serotonin 1 (5-HT1) receptor GPCR IC50 4.70 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 5.57 CHEMBL
Dopamine receptor GPCR IC50 8.74 CHEMBL
Dopamine receptor GPCR Ki 8.70 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 8.38 CHEMBL
Adenylate cyclase Enzyme IC50 5.64 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 7.58 CHEMBL
G protein-activated inward rectifier potassium channel 2 Ion channel GATING INHIBITOR EC50 4.10 IUPHAR
Sigma intracellular receptor 2 Membrane receptor Ki 7.36 CHEMBL
Zinc finger protein 664 Transcription factor Ki 8.18 CHEMBL

External reference:

IDSource
4018123 VUID
N0000146461 NUI
D00136 KEGG_DRUG
53515-91-6 SECONDARY_CAS_RN
4018123 VANDF
4018125 VANDF
C0018546 UMLSCUI
CHEBI:5613 CHEBI
CHEMBL54 ChEMBL_ID
CHEMBL4297147 ChEMBL_ID
DB00502 DRUGBANK_ID
D006220 MESH_DESCRIPTOR_UI
3559 PUBCHEM_CID
86 IUPHAR_LIGAND_ID
918 INN_ID
J6292F8L3D UNII
217483 RXNORM
2958 MMSL
4816 MMSL
4818 MMSL
583 MMSL
d00027 MMSL
001518 NDDF
001521 NDDF
10756001 SNOMEDCT_US
386837002 SNOMEDCT_US
412197008 SNOMEDCT_US
GMJ PDB_CHEM_ID
J6292F8L3D INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0121-0581 SOLUTION 2 mg ORAL ANDA 16 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0143-9319 INJECTION 5 mg INTRAMUSCULAR ANDA 16 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0143-9501 INJECTION 5 mg INTRAMUSCULAR ANDA 16 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0143-9502 INJECTION 5 mg INTRAMUSCULAR ANDA 16 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0214 TABLET 2 mg ORAL ANDA 16 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0257 TABLET 1 mg ORAL ANDA 16 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0327 TABLET 5 mg ORAL ANDA 16 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0334 TABLET 10 mg ORAL ANDA 16 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0335 TABLET 20 mg ORAL ANDA 16 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0351 TABLET 0.50 mg ORAL ANDA 16 sections
Haloperidol Lactate HUMAN PRESCRIPTION DRUG LABEL 1 0404-9871 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 13 sections
Haloperidol Lactate HUMAN PRESCRIPTION DRUG LABEL 1 0404-9871 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 13 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8626 TABLET 5 mg ORAL ANDA 13 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8627 TABLET 10 mg ORAL ANDA 13 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0832-1510 TABLET 0.50 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0832-1520 TABLET 1 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0832-1530 TABLET 2 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0832-1540 TABLET 5 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0832-1550 TABLET 10 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0832-1560 TABLET 20 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-6661 TABLET 20 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-6733 TABLET 10 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-6782 TABLET 5 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-7112 SOLUTION 2 mg ORAL ANDA 13 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-7504 TABLET 2 mg ORAL ANDA 13 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 10135-752 TABLET 0.50 mg ORAL ANDA 12 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 10135-753 TABLET 1 mg ORAL ANDA 12 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 10135-754 TABLET 2 mg ORAL ANDA 12 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 10135-755 TABLET 5 mg ORAL ANDA 12 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 10135-756 TABLET 10 mg ORAL ANDA 12 sections