haloperidol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antipsychotics, haloperidol derivatives 1353 52-86-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • haloperidol
  • aloperidin
  • haloperin
  • sigaperidol
  • haloperidol lactate
A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
  • Molecular weight: 375.87
  • Formula: C21H23ClFNO2
  • CLOGP: 3.85
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 40.54
  • ALOGS: -4.93
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
8 mg O
8 mg P
3.30 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.04 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.57 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 17 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.08 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 35 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 12, 1967 FDA ORTHO MCNEIL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 1267.11 13.53 429 35012 10693 46639928
Extrapyramidal disorder 1206.88 13.53 415 35026 10853 46639768
Intentional self-injury 646.23 13.53 331 35110 23835 46626786
Akathisia 392.06 13.53 165 35276 7549 46643072
Catatonia 365.63 13.53 129 35312 3633 46646988
Dystonia 347.28 13.53 170 35271 11087 46639534
Drug interaction 333.26 13.53 571 34870 202523 46448098
Sopor 330.31 13.53 199 35242 19629 46630992
Muscle rigidity 314.98 13.53 153 35288 9808 46640813
Agitation 312.81 13.53 290 35151 55125 46595496
Psychotic disorder 306.19 13.53 199 35242 22422 46628199
Delirium 264.38 13.53 222 35219 37006 46613615
Delusion 258.27 13.53 139 35302 11049 46639572
Hallucination, auditory 243.73 13.53 132 35309 10624 46639997
Schizophrenia 242.34 13.53 122 35319 8446 46642175
Salivary hypersecretion 234.34 13.53 109 35332 6336 46644285
Hyperprolactinaemia 223.30 13.53 84 35357 2848 46647773
Parkinsonism 218.44 13.53 111 35330 7837 46642784
Sedation 217.21 13.53 162 35279 22748 46627873
Aggression 209.34 13.53 158 35283 22586 46628035
Weight increased 191.65 13.53 400 35041 164073 46486548
Suicide attempt 187.70 13.53 220 35221 54816 46595805
Intentional overdose 183.34 13.53 236 35205 64708 46585913
Tardive dyskinesia 180.49 13.53 96 35345 7447 46643174
Restlessness 174.56 13.53 149 35292 25375 46625246
Psychomotor hyperactivity 174.44 13.53 102 35339 9511 46641110
Somnolence 164.31 13.53 365 35076 156156 46494465
Electrocardiogram QT prolonged 163.20 13.53 198 35243 51127 46599494
Hypothermia 161.91 13.53 106 35335 12077 46638544
Rheumatoid arthritis 156.31 13.53 6 35435 240209 46410412
Pain 152.09 13.53 87 35354 476861 46173760
Arthralgia 150.80 13.53 45 35396 364558 46286063
Coma 140.12 13.53 196 35245 58153 46592468
Confusional state 138.54 13.53 346 35095 159546 46491075
Headache 132.58 13.53 102 35339 478250 46172371
Overdose 129.24 13.53 257 35184 101722 46548899
Fatigue 128.42 13.53 165 35276 608532 46042089
Bradykinesia 119.60 13.53 59 35382 3907 46646714
Abnormal behaviour 118.28 13.53 110 35331 20948 46629673
Blood creatine phosphokinase increased 110.08 13.53 120 35321 27604 46623017
Dysarthria 105.33 13.53 136 35305 37362 46613259
Tremor 105.11 13.53 255 35186 115384 46535237
Torsade de pointes 99.94 13.53 79 35362 12075 46638546
Dyskinesia 99.16 13.53 116 35325 28809 46621812
Hypertonia 98.90 13.53 54 35387 4412 46646209
Galactorrhoea 95.58 13.53 50 35391 3747 46646874
Cogwheel rigidity 93.20 13.53 37 35404 1453 46649168
Mutism 90.90 13.53 35 35406 1265 46649356
Depressed level of consciousness 88.70 13.53 142 35299 47427 46603194
Joint swelling 88.43 13.53 11 35430 166062 46484559
Hallucination 87.57 13.53 145 35296 49806 46600815
Paranoia 87.39 13.53 69 35372 10528 46640093
Blood prolactin increased 85.28 13.53 43 35398 2984 46647637
Bradyphrenia 84.71 13.53 55 35386 6175 46644446
Pain in extremity 83.93 13.53 46 35395 258634 46391987
Mania 83.85 13.53 68 35373 10778 46639843
Embolism venous 83.74 13.53 40 35401 2467 46648154
Sluggishness 83.06 13.53 49 35392 4642 46645979
Tachycardia 77.30 13.53 207 35234 99415 46551206
Stupor 76.40 13.53 42 35399 3478 46647143
Rash 75.58 13.53 96 35345 356416 46294205
Oculogyric crisis 74.97 13.53 30 35411 1203 46649418
Alopecia 72.77 13.53 17 35424 162397 46488224
Pruritus 71.75 13.53 48 35393 242304 46408317
Toxicity to various agents 71.42 13.53 334 35107 211432 46439189
Nausea 67.74 13.53 281 35160 687173 45963448
Altered state of consciousness 66.04 13.53 85 35356 23263 46627358
Treatment noncompliance 65.63 13.53 96 35345 29635 46620986
Suicidal ideation 65.31 13.53 137 35304 56245 46594376
Nasopharyngitis 63.52 13.53 19 35422 153979 46496642
Sinusitis 63.51 13.53 11 35430 129757 46520864
Drug abuse 63.16 13.53 145 35296 63263 46587358
Pleurothotonus 62.80 13.53 26 35415 1139 46649482
Pneumonia aspiration 61.18 13.53 96 35345 31509 46619112
Drooling 60.73 13.53 35 35406 3174 46647447
Schizoaffective disorder 60.47 13.53 27 35414 1425 46649196
Encephalitis autoimmune 60.30 13.53 25 35416 1099 46649522
Negativism 60.28 13.53 19 35422 373 46650248
Injection site pain 59.78 13.53 6 35435 107146 46543475
Drug level increased 58.33 13.53 71 35370 18370 46632251
Infusion related reaction 58.24 13.53 5 35436 101203 46549418
Abdominal discomfort 58.22 13.53 21 35420 151144 46499477
Hypernatraemia 57.83 13.53 44 35397 6357 46644264
Gestational diabetes 57.37 13.53 46 35395 7173 46643448
Dyspnoea 56.95 13.53 201 35240 515347 46135274
Persecutory delusion 56.87 13.53 31 35410 2524 46648097
Ileus paralytic 55.93 13.53 37 35404 4286 46646335
Stereotypy 54.55 13.53 18 35423 411 46650210
Peripheral swelling 54.36 13.53 26 35415 158045 46492576
Swelling 53.88 13.53 14 35427 124497 46526124
Accidental exposure to product by child 53.65 13.53 23 35418 1100 46649521
Diarrhoea 53.62 13.53 231 35210 559371 46091250
Disorientation 52.78 13.53 98 35343 36820 46613801
Arthropathy 52.16 13.53 3 35438 84697 46565924
Cough 51.90 13.53 59 35382 230190 46420431
Granulocytopenia 51.54 13.53 38 35403 5235 46645386
Mental impairment 51.32 13.53 55 35386 12401 46638220
Urinary retention 50.22 13.53 79 35362 25982 46624639
Rhabdomyolysis 48.72 13.53 102 35339 41807 46608814
Back pain 48.23 13.53 53 35388 209986 46440635
Product dose omission issue 46.40 13.53 36 35405 168484 46482137
Toxic epidermal necrolysis 46.39 13.53 70 35371 22208 46628413
Oromandibular dystonia 46.03 13.53 16 35425 430 46650191
Arthritis 43.99 13.53 4 35437 77312 46573309
Miosis 43.73 13.53 38 35403 6619 46644002
Cognitive disorder 43.14 13.53 90 35351 36793 46613828
Antipsychotic drug level increased 42.95 13.53 28 35413 3164 46647457
Psychomotor retardation 42.63 13.53 28 35413 3205 46647416
Psoriasis 42.32 13.53 5 35436 78599 46572022
Mental disorder 41.86 13.53 67 35374 22358 46628263
Hyperammonaemic encephalopathy 41.23 13.53 23 35418 1959 46648662
Serotonin syndrome 40.68 13.53 69 35372 24151 46626470
Hyponatraemia 40.27 13.53 168 35273 101164 46549457
Dysphagia 39.63 13.53 139 35302 77173 46573448
Hyperthermia 39.56 13.53 39 35402 7975 46642646
Injection site erythema 39.41 13.53 5 35436 74422 46576199
Unresponsive to stimuli 39.38 13.53 80 35361 32094 46618527
Lethargy 39.32 13.53 106 35335 51065 46599556
Myalgia 38.27 13.53 23 35418 123065 46527556
Bradycardia 38.22 13.53 124 35317 66174 46584447
Psychotic symptom 38.15 13.53 17 35424 893 46649728
Torticollis 38.11 13.53 21 35420 1746 46648875
Dizziness 37.97 13.53 132 35309 340282 46310339
Waxy flexibility 37.67 13.53 10 35431 103 46650518
Drug intolerance 37.30 13.53 34 35407 147015 46503606
Eosinophilic myocarditis 37.03 13.53 13 35428 360 46650261
Influenza 36.81 13.53 11 35430 89259 46561362
Urticaria 36.69 13.53 22 35419 117870 46532751
Hyperreflexia 36.57 13.53 31 35410 5223 46645398
Chest discomfort 35.66 13.53 12 35429 90257 46560364
Hypersensitivity 35.53 13.53 37 35404 150284 46500337
Systemic lupus erythematosus 35.45 13.53 4 35437 65176 46585445
Akinesia 35.03 13.53 20 35421 1781 46648840
Hallucinations, mixed 33.76 13.53 26 35415 3823 46646798
Paraesthesia 33.72 13.53 24 35417 117413 46533208
Mental status changes 33.48 13.53 83 35358 38005 46612616
White blood cell count increased 33.37 13.53 91 35350 44128 46606493
Illogical thinking 33.01 13.53 8 35433 55 46650566
Abdominal pain upper 32.97 13.53 37 35404 145268 46505353
Somatic symptom disorder of pregnancy 32.81 13.53 9 35432 106 46650515
Hallucination, visual 32.81 13.53 53 35388 17820 46632801
Echolalia 32.80 13.53 10 35431 175 46650446
Herpes zoster 32.65 13.53 6 35435 67866 46582755
Metabolic syndrome 32.58 13.53 17 35424 1267 46649354
Disturbance in attention 32.33 13.53 73 35368 31487 46619134
Chest pain 31.84 13.53 53 35388 176271 46474350
Behaviour disorder 30.88 13.53 19 35422 1942 46648679
Musculoskeletal pain 30.10 13.53 8 35433 70120 46580501
Feeling guilty 29.99 13.53 12 35429 481 46650140
Myocarditis 29.84 13.53 33 35408 7706 46642915
Sexually inappropriate behaviour 29.18 13.53 8 35433 94 46650527
Social avoidant behaviour 28.97 13.53 21 35420 2818 46647803
Neutrophil count increased 28.56 13.53 44 35397 14209 46636412
Flushing 28.45 13.53 7 35434 64607 46586014
Nephrogenic diabetes insipidus 28.03 13.53 13 35428 750 46649871
Cardiac arrest 27.80 13.53 139 35302 90260 46560361
Reduced facial expression 27.70 13.53 15 35426 1205 46649416
Contraindicated product administered 27.69 13.53 13 35428 79934 46570687
Asthenia 27.52 13.53 132 35309 310943 46339678
Sudden death 27.50 13.53 35 35406 9469 46641152
Bronchitis 27.47 13.53 24 35417 105955 46544666
Sinus bradycardia 26.85 13.53 42 35399 13740 46636881
Treatment failure 26.75 13.53 19 35422 93068 46557553
Electrocardiogram PR prolongation 26.63 13.53 12 35429 647 46649974
Flight of ideas 26.60 13.53 10 35431 338 46650283
Psychomotor skills impaired 26.57 13.53 18 35423 2168 46648453
Respiratory failure 26.53 13.53 142 35299 94674 46555947
Refusal of treatment by patient 26.07 13.53 26 35415 5389 46645232
Stress 26.03 13.53 4 35437 51547 46599074
Pulmonary embolism 26.02 13.53 156 35285 108429 46542192
Speech disorder 25.87 13.53 73 35368 36094 46614527
Electroencephalogram abnormal 25.82 13.53 22 35419 3732 46646889
Influenza like illness 25.81 13.53 6 35435 57564 46593057
Contusion 24.95 13.53 18 35423 87469 46563152
Generalised tonic-clonic seizure 24.79 13.53 60 35381 27062 46623559
Inappropriate antidiuretic hormone secretion 24.77 13.53 41 35400 14061 46636560
Asthma 24.62 13.53 20 35421 91522 46559099
Dementia 24.36 13.53 42 35399 14888 46635733
Blunted affect 24.11 13.53 8 35433 186 46650435
Nasal congestion 23.69 13.53 4 35437 48109 46602512
Muscle enzyme increased 23.60 13.53 7 35434 111 46650510
Thinking abnormal 23.57 13.53 33 35408 9781 46640840
Haemoglobin urine 23.48 13.53 7 35434 113 46650508
Burning sensation 23.47 13.53 3 35438 44408 46606213
Disorganised speech 23.45 13.53 12 35429 859 46649762
Differential white blood cell count abnormal 23.40 13.53 11 35430 654 46649967
Weight decreased 23.30 13.53 82 35359 210767 46439854
Opisthotonus 23.30 13.53 9 35432 328 46650293
Acute psychosis 23.26 13.53 16 35425 1976 46648645
Osteoarthritis 23.21 13.53 9 35432 62016 46588605
Exposure during pregnancy 23.14 13.53 151 35290 108061 46542560
Parkinsonian gait 23.08 13.53 10 35431 491 46650130
Dyspnoea exertional 23.03 13.53 5 35436 50284 46600337
Hypersexuality 22.98 13.53 10 35431 496 46650125
Electroconvulsive therapy 22.85 13.53 6 35435 59 46650562
Malaise 22.58 13.53 153 35288 331079 46319542
Screaming 22.56 13.53 19 35422 3172 46647449
Staring 22.53 13.53 14 35427 1456 46649165
Bone marrow eosinophilic leukocyte count increased 22.32 13.53 5 35436 23 46650598
Irritability 22.26 13.53 60 35381 28886 46621735
Drug ineffective 22.17 13.53 372 35069 677466 45973155
Impulsive behaviour 22.14 13.53 14 35427 1501 46649120
Polydipsia 22.11 13.53 19 35422 3260 46647361
False positive investigation result 22.08 13.53 10 35431 546 46650075
General physical health deterioration 22.05 13.53 157 35284 115612 46535009
Diabetic coma 21.76 13.53 11 35430 767 46649854
Malignant catatonia 21.66 13.53 5 35436 27 46650594
Leukocytosis 21.64 13.53 52 35389 23346 46627275
Incorrect route of product administration 21.56 13.53 42 35399 16341 46634280
Amenorrhoea 21.50 13.53 30 35411 8865 46641756
Duodenal stenosis 21.48 13.53 10 35431 582 46650039
Allergic hepatitis 21.36 13.53 5 35436 29 46650592
Hypoaesthesia 21.20 13.53 36 35405 118833 46531788
Rash pruritic 21.07 13.53 4 35437 44211 46606410
Tongue biting 20.93 13.53 13 35428 1351 46649270
Neuropathy peripheral 20.76 13.53 23 35418 90870 46559751
Antipsychotic drug level below therapeutic 20.75 13.53 8 35433 290 46650331
Delusion of reference 20.60 13.53 6 35435 89 46650532
Femoral neck fracture 20.59 13.53 28 35413 8075 46642546
Psychiatric decompensation 20.59 13.53 12 35429 1111 46649510
Protrusion tongue 19.78 13.53 8 35433 330 46650291
Upper respiratory tract infection 19.57 13.53 12 35429 63544 46587077
Injection site reaction 19.53 13.53 6 35435 47843 46602778
Pain in jaw 19.32 13.53 3 35438 38369 46612252
Hyperthermia malignant 19.24 13.53 10 35431 739 46649882
Agranulocytosis 19.13 13.53 48 35393 22137 46628484
Pulmonary vasculitis 18.97 13.53 5 35436 50 46650571
Leukopenia 18.87 13.53 102 35339 68241 46582380
Nuchal rigidity 18.66 13.53 9 35432 567 46650054
Hot flush 18.61 13.53 5 35436 43512 46607109
Pressure of speech 18.60 13.53 9 35432 571 46650050
Hypoxic-ischaemic encephalopathy 18.59 13.53 19 35422 4054 46646567
Clonus 18.57 13.53 19 35422 4061 46646560
Lipids decreased 18.52 13.53 4 35437 15 46650606
Apathy 18.30 13.53 25 35416 7243 46643378
Communication disorder 18.27 13.53 15 35426 2418 46648203
Erythema 18.26 13.53 52 35389 142768 46507853
Wound 18.15 13.53 5 35436 42797 46607824
Venous thrombosis limb 18.12 13.53 16 35425 2847 46647774
Fibromyalgia 18.02 13.53 3 35438 36460 46614161
Red blood cells urine 17.81 13.53 8 35433 428 46650193
Self-medication 17.71 13.53 14 35427 2138 46648483
Multiple sclerosis relapse 17.71 13.53 5 35436 42120 46608501
Electrocardiogram abnormal 17.47 13.53 24 35417 6988 46643633
Dyspepsia 17.15 13.53 16 35425 68456 46582165
Systemic infection 17.11 13.53 9 35432 682 46649939
Coma scale abnormal 17.02 13.53 20 35421 4986 46645635
Dry skin 17.00 13.53 5 35436 41011 46609610
Diabetes mellitus 16.83 13.53 79 35362 49986 46600635
Respiratory depression 16.83 13.53 31 35410 11569 46639052
Anticonvulsant drug level above therapeutic 16.78 13.53 8 35433 491 46650130
Brief psychotic disorder with marked stressors 16.76 13.53 5 35436 81 46650540
Fluid retention 16.62 13.53 9 35432 51037 46599584
Wheezing 16.55 13.53 10 35431 53376 46597245
Prescribed overdose 16.53 13.53 29 35412 10420 46640201
Grandiosity 16.39 13.53 6 35435 188 46650433
Poor personal hygiene 16.36 13.53 7 35434 333 46650288
Impaired healing 16.13 13.53 4 35437 36739 46613882
Decreased eye contact 16.11 13.53 5 35436 93 46650528
Euphoric mood 16.10 13.53 18 35423 4254 46646367
Cardiomyopathy alcoholic 16.08 13.53 4 35437 31 46650590
Blood glucose 16.08 13.53 4 35437 31 46650590
Illusion 16.04 13.53 10 35431 1046 46649575
Anaemia 16.02 13.53 121 35320 255658 46394963
Somatic hallucination 16.01 13.53 3 35438 4 46650617
Seizure 15.95 13.53 153 35288 122901 46527720
Cellulitis 15.82 13.53 18 35423 70270 46580351
Circadian rhythm sleep disorder 15.68 13.53 6 35435 213 46650408
Granulomatous liver disease 15.60 13.53 9 35432 817 46649804
Accidental exposure to product 15.52 13.53 43 35398 21038 46629583
Ureteric obstruction 15.24 13.53 12 35429 1822 46648799
Retinitis pigmentosa 15.16 13.53 5 35436 114 46650507
Apallic syndrome 15.10 13.53 8 35433 615 46650006
Tonic clonic movements 15.09 13.53 10 35431 1162 46649459
Palpitations 15.08 13.53 31 35410 95228 46555393
Hypotonia neonatal 15.08 13.53 9 35432 871 46649750
Dissociation 15.00 13.53 12 35429 1865 46648756
Hypokinesia 14.87 13.53 29 35412 11293 46639328
Epileptic encephalopathy 14.75 13.53 6 35435 251 46650370
Gastrooesophageal reflux disease 14.69 13.53 21 35420 74323 46576298
Electrolyte imbalance 14.57 13.53 37 35404 17189 46633432
Oedema peripheral 14.55 13.53 67 35374 159639 46490982
Cardiac failure congestive 14.40 13.53 30 35411 91720 46558901
Neonatal intestinal obstruction 14.40 13.53 3 35438 9 46650612
Grimacing 14.38 13.53 7 35434 450 46650171
Encephalopathy 14.37 13.53 57 35384 33532 46617089
Carnitine deficiency 14.36 13.53 5 35436 135 46650486
Antidepressant drug level increased 14.28 13.53 6 35435 273 46650348
Autonomic nervous system imbalance 14.25 13.53 13 35428 2413 46648208
Eosinophil count abnormal 14.18 13.53 7 35434 464 46650157
Blood pressure increased 14.15 13.53 49 35392 126617 46524004
Mental disorder due to a general medical condition 14.12 13.53 5 35436 142 46650479
Discomfort 14.11 13.53 9 35432 46661 46603960
Brain oedema 14.06 13.53 30 35411 12448 46638173
Hypomania 14.04 13.53 17 35424 4371 46646250
Echopraxia 13.94 13.53 3 35438 11 46650610
Lactate pyruvate ratio increased 13.88 13.53 4 35437 57 46650564
Mydriasis 13.82 13.53 27 35414 10526 46640095
Optic nerve disorder 13.77 13.53 8 35433 736 46649885
Aspiration of gastric residual 13.73 13.53 3 35438 12 46650609

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 1637.30 12.89 684 43365 15611 29892818
Extrapyramidal disorder 1488.53 12.89 568 43481 10125 29898304
Dystonia 609.95 12.89 294 43755 9433 29898996
Intentional self-injury 510.37 12.89 291 43758 13241 29895188
Agitation 486.11 12.89 492 43557 53581 29854848
Akathisia 396.09 12.89 187 43862 5717 29902712
Muscle rigidity 395.85 12.89 224 43825 10037 29898392
Psychotic disorder 371.61 12.89 284 43765 21231 29887198
Delirium 336.53 12.89 354 43695 40277 29868152
Sedation 327.26 12.89 236 43813 16137 29892292
Aggression 308.19 12.89 323 43726 36584 29871845
Weight increased 304.70 12.89 457 43592 74456 29833973
Parkinsonism 300.25 12.89 166 43883 7103 29901326
Catatonia 294.61 12.89 139 43910 4241 29904188
Tardive dyskinesia 293.34 12.89 145 43904 4912 29903517
Schizophrenia 271.58 12.89 168 43881 8880 29899549
Salivary hypersecretion 238.60 12.89 145 43904 7421 29901008
Sopor 230.10 12.89 163 43886 10828 29897601
Blood creatine phosphokinase increased 223.25 12.89 298 43751 43550 29864879
Hyperprolactinaemia 215.57 12.89 77 43972 1123 29907306
Tachycardia 193.32 12.89 370 43679 73369 29835060
Delusion 184.70 12.89 148 43901 11841 29896588
Drug interaction 184.03 12.89 677 43372 198891 29709538
Electrocardiogram QT prolonged 181.52 12.89 243 43806 35592 29872837
Suicide attempt 180.04 12.89 245 43804 36452 29871977
Hallucination, auditory 179.50 12.89 134 43915 9655 29898774
Dyskinesia 171.35 12.89 185 43864 21649 29886780
Somnolence 171.26 12.89 414 43635 96349 29812080
Intentional overdose 143.28 12.89 235 43814 41246 29867183
Hypertonia 140.71 12.89 85 43964 4300 29904129
Diarrhoea 128.69 12.89 183 43866 333920 29574509
Restlessness 128.03 12.89 162 43887 22437 29885992
Tremor 123.25 12.89 313 43736 75050 29833379
Fatigue 118.23 12.89 181 43868 320492 29587937
Dyspnoea 114.57 12.89 197 43852 333098 29575331
Embolism venous 111.99 12.89 49 44000 1248 29907181
Rhabdomyolysis 109.11 12.89 269 43780 63311 29845118
Arthralgia 105.82 12.89 34 44015 135757 29772672
Rash 105.67 12.89 77 43972 191812 29716617
Granulocytopenia 104.80 12.89 81 43968 6145 29902284
Emotional poverty 104.46 12.89 33 44016 321 29908108
Oculogyric crisis 102.91 12.89 47 44002 1328 29907101
Psychomotor hyperactivity 100.80 12.89 89 43960 8135 29900294
Coma 98.60 12.89 197 43852 40252 29868177
Oropharyngeal spasm 94.71 12.89 26 44023 146 29908283
Nausea 94.41 12.89 184 43865 296773 29611656
Serotonin syndrome 90.04 12.89 121 43928 17770 29890659
Hypothermia 89.31 12.89 89 43960 9478 29898951
Antipsychotic drug level below therapeutic 87.54 12.89 42 44007 1330 29907099
Toxicity to various agents 85.13 12.89 497 43552 176686 29731743
Headache 84.70 12.89 86 43963 182220 29726209
Dizziness 82.79 12.89 99 43950 194810 29713619
Cogwheel rigidity 82.41 12.89 38 44011 1098 29907331
Disinhibition 81.63 12.89 45 44004 1912 29906517
Altered state of consciousness 81.44 12.89 122 43927 19797 29888632
Mutism 80.52 12.89 33 44016 711 29907718
Dysphagia 78.99 12.89 222 43827 56476 29851953
Cognitive disorder 78.78 12.89 132 43917 23558 29884871
Hyperthermia 78.19 12.89 85 43964 10014 29898415
Abnormal behaviour 75.06 12.89 135 43914 25488 29882941
Obsessive-compulsive disorder 74.37 12.89 56 43993 4085 29904344
Asthenia 73.85 12.89 133 43916 221157 29687272
Anaemia 73.05 12.89 121 43928 207871 29700558
Torsade de pointes 72.92 12.89 70 43979 7120 29901309
Pneumonia aspiration 72.49 12.89 167 43882 37613 29870816
Myocardial infarction 69.61 12.89 50 43999 125575 29782854
Cardiac failure congestive 69.60 12.89 19 44030 84388 29824041
Pain in extremity 69.15 12.89 38 44011 110183 29798246
Sluggishness 68.98 12.89 48 44001 3095 29905334
Psychotic symptom 68.66 12.89 34 44015 1155 29907274
Depressed level of consciousness 67.95 12.89 164 43885 38058 29870371
Dysarthria 67.79 12.89 143 43906 30347 29878082
Treatment noncompliance 66.38 12.89 127 43922 25126 29883303
Torticollis 65.84 12.89 32 44017 1043 29907386
Pain 64.81 12.89 96 43953 172545 29735884
Incorrect route of product administration 63.88 12.89 81 43968 11234 29897195
Drooling 63.87 12.89 45 44004 2960 29905469
Cough 63.32 12.89 55 43994 125587 29782842
Opisthotonus 62.03 12.89 23 44026 375 29908054
Paranoia 60.82 12.89 75 43974 10113 29898316
Mania 60.56 12.89 71 43978 9083 29899346
Persecutory delusion 59.82 12.89 38 44011 2102 29906327
Intestinal pseudo-obstruction 58.07 12.89 30 44019 1116 29907313
Protrusion tongue 57.32 12.89 19 44030 218 29908211
Nasopharyngitis 57.24 12.89 9 44040 58840 29849589
Disorientation 57.12 12.89 136 43913 31282 29877147
Spasmodic dysphonia 56.77 12.89 15 44034 71 29908358
Confusional state 56.32 12.89 365 43684 134469 29773960
Myocarditis 55.46 12.89 71 43978 9940 29898489
Accidental exposure to product by child 54.58 12.89 32 44017 1531 29906898
Stupor 53.17 12.89 40 44009 2913 29905516
Antipsychotic drug level increased 50.70 12.89 40 44009 3126 29905303
Hallucination 50.57 12.89 173 43876 48886 29859543
White blood cell count increased 50.08 12.89 150 43899 39523 29868906
Bradykinesia 49.99 12.89 40 44009 3190 29905239
Death 49.26 12.89 316 43733 356967 29551462
Back pain 49.19 12.89 47 44002 102549 29805880
Psychomotor retardation 49.11 12.89 35 44014 2344 29906085
Pneumonia 49.03 12.89 290 43759 334016 29574413
Febrile neutropenia 48.72 12.89 51 43998 106642 29801787
Speech disorder 47.72 12.89 109 43940 24403 29884026
Psoriasis 47.55 12.89 4 44045 42502 29865927
Therapeutic product effect variable 47.35 12.89 28 44021 1361 29907068
Neuropathy peripheral 46.09 12.89 23 44026 70452 29837977
Euphoric mood 45.85 12.89 43 44006 4247 29904182
Hyperreflexia 45.74 12.89 36 44013 2803 29905626
Visceral congestion 45.18 12.89 20 44029 524 29907905
Product dose omission issue 45.07 12.89 41 44008 91590 29816839
Pruritus 45.03 12.89 65 43984 118139 29790290
Infusion related reaction 44.88 12.89 4 44045 40560 29867869
Increased appetite 44.75 12.89 48 44001 5569 29902860
Priapism 44.03 12.89 44 44005 4699 29903730
Myoclonus 44.01 12.89 74 43975 13238 29895191
Schizoaffective disorder 43.18 12.89 24 44025 1036 29907393
Bradyphrenia 42.94 12.89 40 44009 3917 29904512
Oromandibular dystonia 41.55 12.89 18 44031 447 29907982
Disturbance in attention 41.53 12.89 97 43952 22032 29886397
Cerebrovascular accident 41.47 12.89 37 44012 83440 29824989
Peripheral swelling 41.36 12.89 19 44030 61055 29847374
Social avoidant behaviour 41.24 12.89 34 44015 2829 29905600
Interstitial lung disease 40.34 12.89 19 44030 60178 29848251
Water intoxication 40.23 12.89 18 44031 484 29907945
Autonomic nervous system imbalance 39.66 12.89 31 44018 2390 29906039
Eye movement disorder 39.05 12.89 38 44011 3930 29904499
Overdose 38.71 12.89 234 43815 84103 29824326
Abdominal pain upper 38.57 12.89 22 44027 62529 29845900
Product packaging issue 37.76 12.89 17 44032 464 29907965
Ileus paralytic 37.68 12.89 44 44005 5604 29902825
Medication error 37.27 12.89 90 43959 20882 29887547
Influenza 37.23 12.89 9 44040 43389 29865040
Mental impairment 36.74 12.89 56 43993 9221 29899208
Refusal of treatment by patient 36.47 12.89 41 44008 5012 29903417
Self-injurious ideation 36.31 12.89 25 44024 1584 29906845
Pyramidal tract syndrome 36.17 12.89 13 44036 193 29908236
Chest pain 35.42 12.89 75 43974 117552 29790877
Waxy flexibility 35.10 12.89 11 44038 104 29908325
Atrial fibrillation 35.07 12.89 66 43983 108058 29800371
Mental disorder 34.55 12.89 67 43982 13382 29895047
Coronary artery disease 34.39 12.89 15 44034 49697 29858732
Joint swelling 34.37 12.89 13 44036 46933 29861496
Psychosexual disorder 33.95 12.89 10 44039 75 29908354
Trismus 33.89 12.89 28 44021 2337 29906092
Body temperature increased 33.63 12.89 70 43979 14710 29893719
Psychiatric decompensation 33.43 12.89 22 44027 1293 29907136
Tic 33.24 12.89 26 44023 2006 29906423
Urticaria 32.54 12.89 20 44029 54586 29853843
Oral discharge 32.44 12.89 11 44038 136 29908293
Dyslipidaemia 32.33 12.89 41 44008 5686 29902743
Oedema peripheral 32.26 12.89 67 43982 105765 29802664
Choking 32.11 12.89 38 44011 4908 29903521
Erythema 32.11 12.89 40 44009 77411 29831018
Colitis ischaemic 31.99 12.89 41 44008 5745 29902684
Tachypnoea 31.92 12.89 69 43980 14883 29893546
Anticholinergic syndrome 31.78 12.89 18 44031 806 29907623
Huntington's disease 31.60 12.89 9 44040 59 29908370
Rapid eye movement sleep behaviour disorder 31.05 12.89 10 44039 104 29908325
Chest discomfort 31.02 12.89 14 44035 45466 29862963
Blood prolactin abnormal 30.80 12.89 17 44032 724 29907705
Malignant catatonia 30.39 12.89 10 44039 112 29908317
Compulsive sexual behaviour 30.20 12.89 12 44037 238 29908191
Asthma 30.07 12.89 8 44041 36166 29872263
Urinary retention 29.57 12.89 111 43938 32806 29875623
Blood prolactin increased 29.54 12.89 21 44028 1401 29907028
Epistaxis 29.42 12.89 21 44028 52960 29855469
Dyspnoea exertional 29.14 12.89 8 44041 35422 29873007
Epilepsy 29.07 12.89 80 43969 20089 29888340
Delusion of grandeur 28.87 12.89 13 44036 355 29908074
Sinusitis 28.43 12.89 7 44042 33338 29875091
Patient restraint 28.35 12.89 9 44040 89 29908340
Herpes zoster 28.18 12.89 5 44044 29938 29878491
Sinus tachycardia 28.04 12.89 67 43982 15437 29892992
Angina pectoris 27.62 12.89 5 44044 29513 29878916
Decreased appetite 27.59 12.89 120 43929 149790 29758639
Prescribed overdose 27.51 12.89 47 44002 8514 29899915
Leukopenia 27.15 12.89 158 43891 56001 29852428
Injection site pain 26.56 12.89 6 44043 30304 29878125
Gastrointestinal haemorrhage 26.13 12.89 52 43997 83394 29825035
Haemorrhage 25.93 12.89 18 44031 46061 29862368
Drug level increased 25.66 12.89 72 43977 18282 29890147
Arthritis 25.45 12.89 3 44046 24398 29884031
Mental status changes 25.38 12.89 115 43934 36964 29871465
Blunted affect 25.25 12.89 11 44038 277 29908152
Drug withdrawal syndrome neonatal 25.06 12.89 27 44022 3148 29905281
Antipsychotic drug level above therapeutic 25.03 12.89 17 44032 1053 29907376
Obesity 24.94 12.89 45 44004 8510 29899919
Chorea 24.73 12.89 17 44032 1074 29907355
Hypoaesthesia 24.64 12.89 26 44023 54204 29854225
HIV peripheral neuropathy 24.43 12.89 7 44042 47 29908382
Exhibitionism 24.31 12.89 7 44042 48 29908381
Muscle contracture 24.03 12.89 17 44032 1125 29907304
Posturing 24.00 12.89 13 44036 533 29907896
Abdominal discomfort 23.77 12.89 22 44027 48769 29859660
Type 2 diabetes mellitus 23.71 12.89 58 43991 13564 29894865
Musculoskeletal pain 23.61 12.89 8 44041 30932 29877497
Acute myocardial infarction 23.37 12.89 26 44023 52913 29855516
Muscle contractions involuntary 23.36 12.89 20 44029 1753 29906676
Malaise 23.24 12.89 147 43902 166815 29741614
Disease progression 23.14 12.89 52 43997 79822 29828607
Stomatitis 23.13 12.89 13 44036 37266 29871163
Accidental exposure to product 23.12 12.89 48 44001 10067 29898362
Galactorrhoea 23.05 12.89 11 44038 344 29908085
Tension 23.01 12.89 19 44030 1584 29906845
Hallucinations, mixed 22.98 12.89 23 44026 2460 29905969
Vascular stenosis 22.91 12.89 9 44040 173 29908256
Pancytopenia 22.56 12.89 58 43991 84994 29823435
Leukocytosis 22.29 12.89 76 43973 21426 29887003
Cytomegalovirus infection 22.17 12.89 4 44045 23670 29884759
Myalgia 22.14 12.89 50 43999 76617 29831812
Gaze palsy 21.98 12.89 16 44033 1108 29907321
Fluid retention 21.80 12.89 5 44044 24993 29883436
Snoring 21.79 12.89 24 44025 2867 29905562
Aspiration 21.74 12.89 48 44001 10503 29897926
Foetal alcohol syndrome 21.66 12.89 9 44040 201 29908228
Paraesthesia 21.54 12.89 29 44020 54298 29854131
Unresponsive to stimuli 21.21 12.89 86 43963 26333 29882096
Apathy 21.07 12.89 35 44014 6197 29902232
Generalised tonic-clonic seizure 21.06 12.89 70 43979 19481 29888948
Physical assault 20.89 12.89 16 44033 1197 29907232
Intentional product use issue 20.82 12.89 14 44035 36426 29872003
Hyperkalaemia 20.77 12.89 41 44008 65969 29842460
Withdrawal syndrome 20.76 12.89 49 44000 11201 29897228
Drop attacks 20.68 12.89 12 44037 563 29907866
Thrombosis 20.62 12.89 19 44030 42212 29866217
Agranulocytosis 20.54 12.89 75 43974 21867 29886562
Inappropriate affect 20.54 12.89 12 44037 570 29907859
Sexual abuse 20.40 12.89 8 44041 153 29908276
Wheezing 20.36 12.89 10 44039 30928 29877501
Diet refusal 20.32 12.89 10 44039 335 29908094
Flight of ideas 20.00 12.89 10 44039 347 29908082
Reduced facial expression 19.71 12.89 13 44036 767 29907662
Suicidal ideation 19.71 12.89 105 43944 36009 29872420
Renal impairment 19.67 12.89 61 43988 84123 29824306
Hypokinesia 19.67 12.89 37 44012 7223 29901206
Dextrocardia 19.66 12.89 8 44041 169 29908260
Antidepressant drug level increased 19.54 12.89 7 44042 103 29908326
Weight decreased 19.42 12.89 136 43913 150785 29757644
Perseveration 19.41 12.89 7 44042 105 29908324
Antisocial behaviour 19.14 12.89 9 44040 272 29908157
Completed suicide 19.08 12.89 227 43822 99265 29809164
Speech sound disorder 19.02 12.89 6 44043 58 29908371
Sudden death 18.99 12.89 58 43991 15434 29892995
Acute kidney injury 18.99 12.89 286 43763 273556 29634873
Mydriasis 18.79 12.89 33 44016 6110 29902319
Posture abnormal 18.62 12.89 18 44031 1846 29906583
Echolalia 18.49 12.89 8 44041 198 29908231
Condition aggravated 18.47 12.89 295 43754 137571 29770858
Unevaluable event 18.44 12.89 12 44037 31773 29876656
Intentional product misuse 18.38 12.89 100 43949 34567 29873862
Thinking abnormal 18.19 12.89 30 44019 5281 29903148
Postoperative respiratory failure 18.17 12.89 6 44043 68 29908361
Encephalitis toxic 18.14 12.89 7 44042 128 29908301
Reversible splenial lesion syndrome 18.08 12.89 5 44044 29 29908400
Floppy iris syndrome 18.00 12.89 9 44040 312 29908117
Resting tremor 17.95 12.89 11 44038 571 29907858
Productive cough 17.80 12.89 11 44038 29942 29878487
Ascites 17.73 12.89 16 44033 35905 29872524
Skin lesion 17.59 12.89 3 44046 18491 29889938
Neutrophil count increased 17.52 12.89 56 43993 15267 29893162
Parkinsonian gait 17.39 12.89 10 44039 461 29907968
Inappropriate antidiuretic hormone secretion 17.15 12.89 46 44003 11376 29897053
Foetal arrhythmia 16.95 12.89 6 44043 85 29908344
Hyponatraemia 16.94 12.89 162 43887 67040 29841389
Rabbit syndrome 16.82 12.89 4 44045 11 29908418
Gender dysphoria 16.80 12.89 5 44044 39 29908390
Musculoskeletal stiffness 16.72 12.89 100 43949 35781 29872648
Primary familial brain calcification 16.57 12.89 3 44046 0 29908429
Hyperhidrosis 16.55 12.89 161 43888 66929 29841500
Dysphoria 16.48 12.89 18 44031 2130 29906299
Rhinorrhoea 16.48 12.89 5 44044 20749 29887680
Pneumonitis 16.43 12.89 10 44039 27444 29880985
Dysgeusia 16.35 12.89 8 44041 24793 29883636
Judgement impaired 16.33 12.89 11 44038 672 29907757
Cerebrovascular stenosis 16.23 12.89 6 44043 97 29908332
Hyperventilation 16.20 12.89 19 44030 2430 29905999
Irritability 16.15 12.89 72 43977 22978 29885451
Communication disorder 16.13 12.89 18 44031 2182 29906247
Colitis 16.10 12.89 13 44036 30807 29877622
Hypersexuality 16.07 12.89 15 44034 1472 29906957
Haematochezia 16.01 12.89 16 44033 34206 29874223
Myelodysplastic syndrome 15.89 12.89 4 44045 18774 29889655
Cyanosis 15.88 12.89 46 44003 11889 29896540
Malignant neoplasm progression 15.76 12.89 54 43995 72233 29836196
Mumps 15.74 12.89 6 44043 106 29908323
Electrocardiogram J wave 15.68 12.89 4 44045 16 29908413
Seizure 15.64 12.89 217 43832 98258 29810171
Nasal congestion 15.63 12.89 4 44045 18562 29889867
Haemoglobin decreased 15.58 12.89 101 43948 113997 29794432
Impaired self-care 15.57 12.89 12 44037 906 29907523
Syndactyly 15.56 12.89 11 44038 727 29907702
Sexual dysfunction 15.54 12.89 30 44019 5971 29902458
Labile blood pressure 15.21 12.89 10 44039 587 29907842
Chills 15.13 12.89 55 43994 72283 29836146
Syncope 14.97 12.89 69 43980 84834 29823595
Symptom masked 14.92 12.89 9 44040 454 29907975
Haematuria 14.85 12.89 27 44022 44807 29863622
Delusional disorder, unspecified type 14.84 12.89 11 44038 783 29907646
Hyperammonaemia 14.79 12.89 28 44021 5492 29902937
Schizoaffective disorder bipolar type 14.73 12.89 5 44044 62 29908367
Cerebral haemorrhage 14.68 12.89 16 44033 32871 29875558
Pleurothotonus 14.42 12.89 12 44037 1011 29907418
Ventricular fibrillation 14.39 12.89 52 43997 15086 29893343
Temporal lobe epilepsy 14.36 12.89 6 44043 136 29908293
Adactyly 14.31 12.89 5 44044 68 29908361
Coma scale abnormal 14.25 12.89 21 44028 3355 29905074
Visual acuity reduced 14.16 12.89 3 44046 15843 29892586
Cholelithiasis 14.15 12.89 6 44043 20219 29888210
Multiple organ dysfunction syndrome 14.13 12.89 47 44002 63440 29844989
Affective disorder 14.10 12.89 20 44029 3088 29905341
Swollen tongue 14.00 12.89 47 44002 13145 29895284
Drug-disease interaction 13.89 12.89 7 44042 247 29908182
Neuroleptic-induced deficit syndrome 13.82 12.89 4 44045 28 29908401
Differential white blood cell count abnormal 13.80 12.89 13 44036 1291 29907138
Bacteraemia 13.79 12.89 3 44046 15557 29892872
Diabetic coma 13.74 12.89 11 44038 878 29907551
Diabetes mellitus 13.73 12.89 107 43942 41758 29866671
Coprolalia 13.70 12.89 4 44045 29 29908400
Rebound effect 13.61 12.89 14 44035 1547 29906882
Hypersensitivity 13.45 12.89 38 44011 53990 29854439
Chronic obstructive pulmonary disease 13.37 12.89 30 44019 46096 29862333
Scrotal haematoma 13.35 12.89 5 44044 84 29908345
Dyslexia 13.32 12.89 6 44043 164 29908265
Substance-induced psychotic disorder 13.24 12.89 13 44036 1359 29907070
Hyporeflexia 13.19 12.89 15 44034 1857 29906572
Polydipsia 13.18 12.89 21 44028 3592 29904837
Acute psychosis 13.16 12.89 15 44034 1861 29906568
Wrong product administered 13.09 12.89 24 44025 4594 29903835
Incontinence 13.03 12.89 26 44023 5300 29903129
Renal failure 13.02 12.89 124 43925 128842 29779587
Breathing-related sleep disorder 12.96 12.89 6 44043 175 29908254
Victim of crime 12.95 12.89 7 44042 286 29908143
Paraphilia 12.93 12.89 5 44044 92 29908337
Cardio-respiratory arrest 12.91 12.89 135 43914 57171 29851258

Pharmacologic Action:

SourceCodeDescription
ATC N05AD01 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Butyrophenone derivatives
CHEBI has role CHEBI:48279 serotonin antagonists
CHEBI has role CHEBI:48561 dopamine blocker
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:65190 typical antipsychotic drug
CHEBI has role CHEBI:66956 antidyskinetic drugs
MeSH PA D018726 Anti-Dyskinesia Agents
MeSH PA D000932 Antiemetics
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D015259 Dopamine Agents
MeSH PA D018492 Dopamine Antagonists
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
FDA EPC N0000180182 Typical Antipsychotic

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Gilles de la Tourette's syndrome indication 5158005 DOID:11119
Schizophrenia indication 58214004 DOID:5419
Psychotic disorder indication 69322001
Chronic schizophrenia indication 83746006
Delirium off-label use 2776000
Nausea and vomiting off-label use 16932000
Pain off-label use 22253000
Anxiety disorder off-label use 197480006 DOID:2030
Headache disorder off-label use 230461009
Gastroparesis off-label use 235675006
Chemotherapy-induced nausea and vomiting off-label use 236084000
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Thyrotoxic crisis contraindication 29028009 DOID:12837
Torsades de pointes contraindication 31722008
Parkinsonism contraindication 32798002
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Extrapyramidal disease contraindication 76349003
Leukopenia contraindication 84828003 DOID:615
Tardive dyskinesia contraindication 102449007
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Hypomagnesemia contraindication 190855004
Angina pectoris contraindication 194828000
Disease of liver contraindication 235856003 DOID:409
Retention of urine contraindication 267064002
Neutropenic disorder contraindication 303011007 DOID:1227
Coma contraindication 371632003
Breastfeeding (mother) contraindication 413712001
Central nervous system depression contraindication 418072004
Acquired torsion dystonia contraindication 433493000
Congenital long QT syndrome contraindication 442917000
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002
Drug Induced CNS Depression contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.36 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR INVERSE AGONIST Ki 9.15 WOMBAT-PK CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 8.10 PDSP
5-hydroxytryptamine receptor 1B GPCR Ki 6.57 PDSP
Histamine H2 receptor GPCR Ki 6.00 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 5 PDSP
Alpha-2C adrenergic receptor GPCR Ki 6.26 PDSP
Alpha-2B adrenergic receptor GPCR Ki 6.32 PDSP
Alpha-2A adrenergic receptor GPCR Ki 5.95 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 6.18 PDSP
5-hydroxytryptamine receptor 1D GPCR ANTAGONIST Ki 6.60 IUPHAR
Potassium voltage-gated channel subfamily H member 1 Ion channel BLOCKER IC50 6.20 IUPHAR
Mu-type opioid receptor GPCR Ki 6.00 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.74 DRUG MATRIX
Alpha-1D adrenergic receptor GPCR Ki 7.55 DRUG MATRIX
D(3) dopamine receptor GPCR INVERSE AGONIST Ki 8.52 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 7 WOMBAT-PK
Sigma non-opioid intracellular receptor 1 Membrane receptor EC50 8.92 WOMBAT-PK
Calmodulin Cytosolic other IC50 6.30 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 7.52 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 7.90 WOMBAT-PK
5-hydroxytryptamine receptor 7 GPCR Ki 6.45 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 6.10 WOMBAT-PK
Multidrug resistance protein 1 Transporter Ki 6.70 WOMBAT-PK
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase Enzyme Ki 6.72 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 7.50 WOMBAT-PK
D(1A) dopamine receptor GPCR Ki 7.82 WOMBAT-PK
5-hydroxytryptamine receptor 1A GPCR Ki 5.55 CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 5.92 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 5.80 CHEMBL
5-hydroxytryptamine receptor 6 GPCR Ki 5.22 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 5.33 CHEMBL
Histamine H1 receptor GPCR Ki 6.36 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 5.74 CHEMBL
5-hydroxytryptamine receptor 1E GPCR Ki 5.30 PDSP
5-hydroxytryptamine receptor 1F GPCR Ki 5.30 PDSP
Beta-2 adrenergic receptor GPCR Ki 5.30 PDSP
D(4) dopamine receptor GPCR INVERSE AGONIST Kd 9.42 SCIENTIFIC LITERATURE
5-hydroxytryptamine receptor 5A GPCR Ki 5.65 PDSP
Alpha-1B adrenergic receptor GPCR Ki 8.31 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 7.44 DRUG MATRIX
Transporter Transporter Ki 5.26 CHEMBL
Dopamine receptor GPCR IC50 8.74 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 6.58 CHEMBL
Muscarinic acetylcholine receptor GPCR Ki 5.13 CHEMBL
D(2) dopamine receptor GPCR Ki 9.52 CHEMBL
D(3) dopamine receptor GPCR Ki 8.52 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 8.38 CHEMBL
Dopamine receptor GPCR Ki 8.70 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 5.57 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 7.70 CHEMBL
AP-2 complex subunit sigma Unclassified Ki 7.62 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 5.74 CHEMBL
Adenylate cyclase Enzyme IC50 5.64 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 6.62 CHEMBL
D(3) dopamine receptor GPCR Ki 8.52 CHEMBL
Alpha-1A adrenergic receptor GPCR Kd 7.76 CHEMBL
Serotonin 1 (5-HT1) receptor GPCR IC50 4.70 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 6.40 CHEMBL
D(1A) dopamine receptor GPCR Ki 7.70 CHEMBL
Pol polyprotein Enzyme Ki 7 CHEMBL
Histamine H1 receptor GPCR Ki 6.42 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 7.52 CHEMBL
Opioid receptor GPCR Ki 5.92 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 9.05 CHEMBL
D(2) dopamine receptor GPCR Ki 8.32 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 7.58 CHEMBL
5-hydroxytryptamine receptor 2A GPCR IC50 7.52 CHEMBL
D(2) dopamine receptor GPCR Ki 9.70 CHEMBL
Protease Enzyme Ki 7 CHEMBL
D(1A) dopamine receptor GPCR Ki 7.03 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane other Ki 9.08 CHEMBL
C-8 sterol isomerase Enzyme Ki 9.30 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 7.35 CHEMBL
Histamine H1 receptor GPCR Ki 6.40 CHEMBL
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 6.30 IUPHAR
G protein-activated inward rectifier potassium channel 2 Ion channel GATING INHIBITOR EC50 4.10 IUPHAR

External reference:

IDSource
4018123 VUID
N0000146461 NUI
D00136 KEGG_DRUG
53515-91-6 SECONDARY_CAS_RN
4018123 VANDF
4018125 VANDF
C0018546 UMLSCUI
CHEBI:5613 CHEBI
GMJ PDB_CHEM_ID
CHEMBL54 ChEMBL_ID
CHEMBL2096643 ChEMBL_ID
CHEMBL4297147 ChEMBL_ID
DB00502 DRUGBANK_ID
3559 PUBCHEM_CID
D006220 MESH_DESCRIPTOR_UI
86 IUPHAR_LIGAND_ID
918 INN_ID
J6292F8L3D UNII
217483 RXNORM
2958 MMSL
4816 MMSL
4818 MMSL
583 MMSL
d00027 MMSL
001518 NDDF
001521 NDDF
10756001 SNOMEDCT_US
386837002 SNOMEDCT_US
412197008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0121-0581 SOLUTION 2 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0143-9319 INJECTION 5 mg INTRAMUSCULAR ANDA 16 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0143-9501 INJECTION 5 mg INTRAMUSCULAR ANDA 16 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0143-9502 INJECTION 5 mg INTRAMUSCULAR ANDA 16 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0214 TABLET 2 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0257 TABLET 1 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0327 TABLET 5 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0334 TABLET 10 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0335 TABLET 20 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0351 TABLET 0.50 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8355 TABLET 5 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0832-1510 TABLET 0.50 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0832-1520 TABLET 1 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0832-1530 TABLET 2 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0832-1540 TABLET 5 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0832-1550 TABLET 10 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0832-1560 TABLET 20 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-5923 TABLET 1 mg ORAL ANDA 18 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-5924 TABLET 2 mg ORAL ANDA 18 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-5925 TABLET 5 mg ORAL ANDA 18 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-6413 TABLET 10 mg ORAL ANDA 18 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-6661 TABLET 20 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-6733 TABLET 10 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-6782 TABLET 5 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-7112 SOLUTION 2 mg ORAL ANDA 13 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 10147-0911 INJECTION 5 mg INTRAMUSCULAR NDA AUTHORIZED GENERIC 24 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 17478-110 INJECTION 5 mg INTRAMUSCULAR ANDA 22 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 17856-0501 SOLUTION 2 mg ORAL ANDA 13 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 17856-0581 SOLUTION, CONCENTRATE 2 mg ORAL ANDA 16 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 17856-0730 TABLET 5 mg ORAL ANDA 16 sections