haloperidol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antipsychotics, haloperidol derivatives	1353	52-86-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: haloperidol aloperidin haloperin sigaperidol haloperidol lactate	A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279) Molecular weight: 375.87 Formula: C21H23ClFNO2 CLOGP: 3.85 LIPINSKI: 0 HAC: 3 HDO: 1 TPSA: 40.54 ALOGS: -4.93 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

haloperidol
aloperidin
haloperin
sigaperidol
haloperidol lactate

A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)

Molecular weight: 375.87
Formula: C21H23ClFNO2
CLOGP: 3.85
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 40.54
ALOGS: -4.93
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
8	mg	O
8	mg	P
3.30	mg	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.04 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	1 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.57 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	60 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	17 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	7.80 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.08 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	35 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
April 12, 1967	FDA	ORTHO MCNEIL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Neuroleptic malignant syndrome	1267.11	13.53	429	35012	10693	46639928
Extrapyramidal disorder	1206.88	13.53	415	35026	10853	46639768
Intentional self-injury	646.23	13.53	331	35110	23835	46626786
Akathisia	392.06	13.53	165	35276	7549	46643072
Catatonia	365.63	13.53	129	35312	3633	46646988
Dystonia	347.28	13.53	170	35271	11087	46639534
Drug interaction	333.26	13.53	571	34870	202523	46448098
Sopor	330.31	13.53	199	35242	19629	46630992
Muscle rigidity	314.98	13.53	153	35288	9808	46640813
Agitation	312.81	13.53	290	35151	55125	46595496
Psychotic disorder	306.19	13.53	199	35242	22422	46628199
Delirium	264.38	13.53	222	35219	37006	46613615
Delusion	258.27	13.53	139	35302	11049	46639572
Hallucination, auditory	243.73	13.53	132	35309	10624	46639997
Schizophrenia	242.34	13.53	122	35319	8446	46642175
Salivary hypersecretion	234.34	13.53	109	35332	6336	46644285
Hyperprolactinaemia	223.30	13.53	84	35357	2848	46647773
Parkinsonism	218.44	13.53	111	35330	7837	46642784
Sedation	217.21	13.53	162	35279	22748	46627873
Aggression	209.34	13.53	158	35283	22586	46628035
Weight increased	191.65	13.53	400	35041	164073	46486548
Suicide attempt	187.70	13.53	220	35221	54816	46595805
Intentional overdose	183.34	13.53	236	35205	64708	46585913
Tardive dyskinesia	180.49	13.53	96	35345	7447	46643174
Restlessness	174.56	13.53	149	35292	25375	46625246
Psychomotor hyperactivity	174.44	13.53	102	35339	9511	46641110
Somnolence	164.31	13.53	365	35076	156156	46494465
Electrocardiogram QT prolonged	163.20	13.53	198	35243	51127	46599494
Hypothermia	161.91	13.53	106	35335	12077	46638544
Rheumatoid arthritis	156.31	13.53	6	35435	240209	46410412
Pain	152.09	13.53	87	35354	476861	46173760
Arthralgia	150.80	13.53	45	35396	364558	46286063
Coma	140.12	13.53	196	35245	58153	46592468
Confusional state	138.54	13.53	346	35095	159546	46491075
Headache	132.58	13.53	102	35339	478250	46172371
Overdose	129.24	13.53	257	35184	101722	46548899
Fatigue	128.42	13.53	165	35276	608532	46042089
Bradykinesia	119.60	13.53	59	35382	3907	46646714
Abnormal behaviour	118.28	13.53	110	35331	20948	46629673
Blood creatine phosphokinase increased	110.08	13.53	120	35321	27604	46623017
Dysarthria	105.33	13.53	136	35305	37362	46613259
Tremor	105.11	13.53	255	35186	115384	46535237
Torsade de pointes	99.94	13.53	79	35362	12075	46638546
Dyskinesia	99.16	13.53	116	35325	28809	46621812
Hypertonia	98.90	13.53	54	35387	4412	46646209
Galactorrhoea	95.58	13.53	50	35391	3747	46646874
Cogwheel rigidity	93.20	13.53	37	35404	1453	46649168
Mutism	90.90	13.53	35	35406	1265	46649356
Depressed level of consciousness	88.70	13.53	142	35299	47427	46603194
Joint swelling	88.43	13.53	11	35430	166062	46484559
Hallucination	87.57	13.53	145	35296	49806	46600815
Paranoia	87.39	13.53	69	35372	10528	46640093
Blood prolactin increased	85.28	13.53	43	35398	2984	46647637
Bradyphrenia	84.71	13.53	55	35386	6175	46644446
Pain in extremity	83.93	13.53	46	35395	258634	46391987
Mania	83.85	13.53	68	35373	10778	46639843
Embolism venous	83.74	13.53	40	35401	2467	46648154
Sluggishness	83.06	13.53	49	35392	4642	46645979
Tachycardia	77.30	13.53	207	35234	99415	46551206
Stupor	76.40	13.53	42	35399	3478	46647143
Rash	75.58	13.53	96	35345	356416	46294205
Oculogyric crisis	74.97	13.53	30	35411	1203	46649418
Alopecia	72.77	13.53	17	35424	162397	46488224
Pruritus	71.75	13.53	48	35393	242304	46408317
Toxicity to various agents	71.42	13.53	334	35107	211432	46439189
Nausea	67.74	13.53	281	35160	687173	45963448
Altered state of consciousness	66.04	13.53	85	35356	23263	46627358
Treatment noncompliance	65.63	13.53	96	35345	29635	46620986
Suicidal ideation	65.31	13.53	137	35304	56245	46594376
Nasopharyngitis	63.52	13.53	19	35422	153979	46496642
Sinusitis	63.51	13.53	11	35430	129757	46520864
Drug abuse	63.16	13.53	145	35296	63263	46587358
Pleurothotonus	62.80	13.53	26	35415	1139	46649482
Pneumonia aspiration	61.18	13.53	96	35345	31509	46619112
Drooling	60.73	13.53	35	35406	3174	46647447
Schizoaffective disorder	60.47	13.53	27	35414	1425	46649196
Encephalitis autoimmune	60.30	13.53	25	35416	1099	46649522
Negativism	60.28	13.53	19	35422	373	46650248
Injection site pain	59.78	13.53	6	35435	107146	46543475
Drug level increased	58.33	13.53	71	35370	18370	46632251
Infusion related reaction	58.24	13.53	5	35436	101203	46549418
Abdominal discomfort	58.22	13.53	21	35420	151144	46499477
Hypernatraemia	57.83	13.53	44	35397	6357	46644264
Gestational diabetes	57.37	13.53	46	35395	7173	46643448
Dyspnoea	56.95	13.53	201	35240	515347	46135274
Persecutory delusion	56.87	13.53	31	35410	2524	46648097
Ileus paralytic	55.93	13.53	37	35404	4286	46646335
Stereotypy	54.55	13.53	18	35423	411	46650210
Peripheral swelling	54.36	13.53	26	35415	158045	46492576
Swelling	53.88	13.53	14	35427	124497	46526124
Accidental exposure to product by child	53.65	13.53	23	35418	1100	46649521
Diarrhoea	53.62	13.53	231	35210	559371	46091250
Disorientation	52.78	13.53	98	35343	36820	46613801
Arthropathy	52.16	13.53	3	35438	84697	46565924
Cough	51.90	13.53	59	35382	230190	46420431
Granulocytopenia	51.54	13.53	38	35403	5235	46645386
Mental impairment	51.32	13.53	55	35386	12401	46638220
Urinary retention	50.22	13.53	79	35362	25982	46624639
Rhabdomyolysis	48.72	13.53	102	35339	41807	46608814
Back pain	48.23	13.53	53	35388	209986	46440635
Product dose omission issue	46.40	13.53	36	35405	168484	46482137
Toxic epidermal necrolysis	46.39	13.53	70	35371	22208	46628413
Oromandibular dystonia	46.03	13.53	16	35425	430	46650191
Arthritis	43.99	13.53	4	35437	77312	46573309
Miosis	43.73	13.53	38	35403	6619	46644002
Cognitive disorder	43.14	13.53	90	35351	36793	46613828
Antipsychotic drug level increased	42.95	13.53	28	35413	3164	46647457
Psychomotor retardation	42.63	13.53	28	35413	3205	46647416
Psoriasis	42.32	13.53	5	35436	78599	46572022
Mental disorder	41.86	13.53	67	35374	22358	46628263
Hyperammonaemic encephalopathy	41.23	13.53	23	35418	1959	46648662
Serotonin syndrome	40.68	13.53	69	35372	24151	46626470
Hyponatraemia	40.27	13.53	168	35273	101164	46549457
Dysphagia	39.63	13.53	139	35302	77173	46573448
Hyperthermia	39.56	13.53	39	35402	7975	46642646
Injection site erythema	39.41	13.53	5	35436	74422	46576199
Unresponsive to stimuli	39.38	13.53	80	35361	32094	46618527
Lethargy	39.32	13.53	106	35335	51065	46599556
Myalgia	38.27	13.53	23	35418	123065	46527556
Bradycardia	38.22	13.53	124	35317	66174	46584447
Psychotic symptom	38.15	13.53	17	35424	893	46649728
Torticollis	38.11	13.53	21	35420	1746	46648875
Dizziness	37.97	13.53	132	35309	340282	46310339
Waxy flexibility	37.67	13.53	10	35431	103	46650518
Drug intolerance	37.30	13.53	34	35407	147015	46503606
Eosinophilic myocarditis	37.03	13.53	13	35428	360	46650261
Influenza	36.81	13.53	11	35430	89259	46561362
Urticaria	36.69	13.53	22	35419	117870	46532751
Hyperreflexia	36.57	13.53	31	35410	5223	46645398
Chest discomfort	35.66	13.53	12	35429	90257	46560364
Hypersensitivity	35.53	13.53	37	35404	150284	46500337
Systemic lupus erythematosus	35.45	13.53	4	35437	65176	46585445
Akinesia	35.03	13.53	20	35421	1781	46648840
Hallucinations, mixed	33.76	13.53	26	35415	3823	46646798
Paraesthesia	33.72	13.53	24	35417	117413	46533208
Mental status changes	33.48	13.53	83	35358	38005	46612616
White blood cell count increased	33.37	13.53	91	35350	44128	46606493
Illogical thinking	33.01	13.53	8	35433	55	46650566
Abdominal pain upper	32.97	13.53	37	35404	145268	46505353
Somatic symptom disorder of pregnancy	32.81	13.53	9	35432	106	46650515
Hallucination, visual	32.81	13.53	53	35388	17820	46632801
Echolalia	32.80	13.53	10	35431	175	46650446
Herpes zoster	32.65	13.53	6	35435	67866	46582755
Metabolic syndrome	32.58	13.53	17	35424	1267	46649354
Disturbance in attention	32.33	13.53	73	35368	31487	46619134
Chest pain	31.84	13.53	53	35388	176271	46474350
Behaviour disorder	30.88	13.53	19	35422	1942	46648679
Musculoskeletal pain	30.10	13.53	8	35433	70120	46580501
Feeling guilty	29.99	13.53	12	35429	481	46650140
Myocarditis	29.84	13.53	33	35408	7706	46642915
Sexually inappropriate behaviour	29.18	13.53	8	35433	94	46650527
Social avoidant behaviour	28.97	13.53	21	35420	2818	46647803
Neutrophil count increased	28.56	13.53	44	35397	14209	46636412
Flushing	28.45	13.53	7	35434	64607	46586014
Nephrogenic diabetes insipidus	28.03	13.53	13	35428	750	46649871
Cardiac arrest	27.80	13.53	139	35302	90260	46560361
Reduced facial expression	27.70	13.53	15	35426	1205	46649416
Contraindicated product administered	27.69	13.53	13	35428	79934	46570687
Asthenia	27.52	13.53	132	35309	310943	46339678
Sudden death	27.50	13.53	35	35406	9469	46641152
Bronchitis	27.47	13.53	24	35417	105955	46544666
Sinus bradycardia	26.85	13.53	42	35399	13740	46636881
Treatment failure	26.75	13.53	19	35422	93068	46557553
Electrocardiogram PR prolongation	26.63	13.53	12	35429	647	46649974
Flight of ideas	26.60	13.53	10	35431	338	46650283
Psychomotor skills impaired	26.57	13.53	18	35423	2168	46648453
Respiratory failure	26.53	13.53	142	35299	94674	46555947
Refusal of treatment by patient	26.07	13.53	26	35415	5389	46645232
Stress	26.03	13.53	4	35437	51547	46599074
Pulmonary embolism	26.02	13.53	156	35285	108429	46542192
Speech disorder	25.87	13.53	73	35368	36094	46614527
Electroencephalogram abnormal	25.82	13.53	22	35419	3732	46646889
Influenza like illness	25.81	13.53	6	35435	57564	46593057
Contusion	24.95	13.53	18	35423	87469	46563152
Generalised tonic-clonic seizure	24.79	13.53	60	35381	27062	46623559
Inappropriate antidiuretic hormone secretion	24.77	13.53	41	35400	14061	46636560
Asthma	24.62	13.53	20	35421	91522	46559099
Dementia	24.36	13.53	42	35399	14888	46635733
Blunted affect	24.11	13.53	8	35433	186	46650435
Nasal congestion	23.69	13.53	4	35437	48109	46602512
Muscle enzyme increased	23.60	13.53	7	35434	111	46650510
Thinking abnormal	23.57	13.53	33	35408	9781	46640840
Haemoglobin urine	23.48	13.53	7	35434	113	46650508
Burning sensation	23.47	13.53	3	35438	44408	46606213
Disorganised speech	23.45	13.53	12	35429	859	46649762
Differential white blood cell count abnormal	23.40	13.53	11	35430	654	46649967
Weight decreased	23.30	13.53	82	35359	210767	46439854
Opisthotonus	23.30	13.53	9	35432	328	46650293
Acute psychosis	23.26	13.53	16	35425	1976	46648645
Osteoarthritis	23.21	13.53	9	35432	62016	46588605
Exposure during pregnancy	23.14	13.53	151	35290	108061	46542560
Parkinsonian gait	23.08	13.53	10	35431	491	46650130
Dyspnoea exertional	23.03	13.53	5	35436	50284	46600337
Hypersexuality	22.98	13.53	10	35431	496	46650125
Electroconvulsive therapy	22.85	13.53	6	35435	59	46650562
Malaise	22.58	13.53	153	35288	331079	46319542
Screaming	22.56	13.53	19	35422	3172	46647449
Staring	22.53	13.53	14	35427	1456	46649165
Bone marrow eosinophilic leukocyte count increased	22.32	13.53	5	35436	23	46650598
Irritability	22.26	13.53	60	35381	28886	46621735
Drug ineffective	22.17	13.53	372	35069	677466	45973155
Impulsive behaviour	22.14	13.53	14	35427	1501	46649120
Polydipsia	22.11	13.53	19	35422	3260	46647361
False positive investigation result	22.08	13.53	10	35431	546	46650075
General physical health deterioration	22.05	13.53	157	35284	115612	46535009
Diabetic coma	21.76	13.53	11	35430	767	46649854
Malignant catatonia	21.66	13.53	5	35436	27	46650594
Leukocytosis	21.64	13.53	52	35389	23346	46627275
Incorrect route of product administration	21.56	13.53	42	35399	16341	46634280
Amenorrhoea	21.50	13.53	30	35411	8865	46641756
Duodenal stenosis	21.48	13.53	10	35431	582	46650039
Allergic hepatitis	21.36	13.53	5	35436	29	46650592
Hypoaesthesia	21.20	13.53	36	35405	118833	46531788
Rash pruritic	21.07	13.53	4	35437	44211	46606410
Tongue biting	20.93	13.53	13	35428	1351	46649270
Neuropathy peripheral	20.76	13.53	23	35418	90870	46559751
Antipsychotic drug level below therapeutic	20.75	13.53	8	35433	290	46650331
Delusion of reference	20.60	13.53	6	35435	89	46650532
Femoral neck fracture	20.59	13.53	28	35413	8075	46642546
Psychiatric decompensation	20.59	13.53	12	35429	1111	46649510
Protrusion tongue	19.78	13.53	8	35433	330	46650291
Upper respiratory tract infection	19.57	13.53	12	35429	63544	46587077
Injection site reaction	19.53	13.53	6	35435	47843	46602778
Pain in jaw	19.32	13.53	3	35438	38369	46612252
Hyperthermia malignant	19.24	13.53	10	35431	739	46649882
Agranulocytosis	19.13	13.53	48	35393	22137	46628484
Pulmonary vasculitis	18.97	13.53	5	35436	50	46650571
Leukopenia	18.87	13.53	102	35339	68241	46582380
Nuchal rigidity	18.66	13.53	9	35432	567	46650054
Hot flush	18.61	13.53	5	35436	43512	46607109
Pressure of speech	18.60	13.53	9	35432	571	46650050
Hypoxic-ischaemic encephalopathy	18.59	13.53	19	35422	4054	46646567
Clonus	18.57	13.53	19	35422	4061	46646560
Lipids decreased	18.52	13.53	4	35437	15	46650606
Apathy	18.30	13.53	25	35416	7243	46643378
Communication disorder	18.27	13.53	15	35426	2418	46648203
Erythema	18.26	13.53	52	35389	142768	46507853
Wound	18.15	13.53	5	35436	42797	46607824
Venous thrombosis limb	18.12	13.53	16	35425	2847	46647774
Fibromyalgia	18.02	13.53	3	35438	36460	46614161
Red blood cells urine	17.81	13.53	8	35433	428	46650193
Self-medication	17.71	13.53	14	35427	2138	46648483
Multiple sclerosis relapse	17.71	13.53	5	35436	42120	46608501
Electrocardiogram abnormal	17.47	13.53	24	35417	6988	46643633
Dyspepsia	17.15	13.53	16	35425	68456	46582165
Systemic infection	17.11	13.53	9	35432	682	46649939
Coma scale abnormal	17.02	13.53	20	35421	4986	46645635
Dry skin	17.00	13.53	5	35436	41011	46609610
Diabetes mellitus	16.83	13.53	79	35362	49986	46600635
Respiratory depression	16.83	13.53	31	35410	11569	46639052
Anticonvulsant drug level above therapeutic	16.78	13.53	8	35433	491	46650130
Brief psychotic disorder with marked stressors	16.76	13.53	5	35436	81	46650540
Fluid retention	16.62	13.53	9	35432	51037	46599584
Wheezing	16.55	13.53	10	35431	53376	46597245
Prescribed overdose	16.53	13.53	29	35412	10420	46640201
Grandiosity	16.39	13.53	6	35435	188	46650433
Poor personal hygiene	16.36	13.53	7	35434	333	46650288
Impaired healing	16.13	13.53	4	35437	36739	46613882
Decreased eye contact	16.11	13.53	5	35436	93	46650528
Euphoric mood	16.10	13.53	18	35423	4254	46646367
Cardiomyopathy alcoholic	16.08	13.53	4	35437	31	46650590
Blood glucose	16.08	13.53	4	35437	31	46650590
Illusion	16.04	13.53	10	35431	1046	46649575
Anaemia	16.02	13.53	121	35320	255658	46394963
Somatic hallucination	16.01	13.53	3	35438	4	46650617
Seizure	15.95	13.53	153	35288	122901	46527720
Cellulitis	15.82	13.53	18	35423	70270	46580351
Circadian rhythm sleep disorder	15.68	13.53	6	35435	213	46650408
Granulomatous liver disease	15.60	13.53	9	35432	817	46649804
Accidental exposure to product	15.52	13.53	43	35398	21038	46629583
Ureteric obstruction	15.24	13.53	12	35429	1822	46648799
Retinitis pigmentosa	15.16	13.53	5	35436	114	46650507
Apallic syndrome	15.10	13.53	8	35433	615	46650006
Tonic clonic movements	15.09	13.53	10	35431	1162	46649459
Palpitations	15.08	13.53	31	35410	95228	46555393
Hypotonia neonatal	15.08	13.53	9	35432	871	46649750
Dissociation	15.00	13.53	12	35429	1865	46648756
Hypokinesia	14.87	13.53	29	35412	11293	46639328
Epileptic encephalopathy	14.75	13.53	6	35435	251	46650370
Gastrooesophageal reflux disease	14.69	13.53	21	35420	74323	46576298
Electrolyte imbalance	14.57	13.53	37	35404	17189	46633432
Oedema peripheral	14.55	13.53	67	35374	159639	46490982
Cardiac failure congestive	14.40	13.53	30	35411	91720	46558901
Neonatal intestinal obstruction	14.40	13.53	3	35438	9	46650612
Grimacing	14.38	13.53	7	35434	450	46650171
Encephalopathy	14.37	13.53	57	35384	33532	46617089
Carnitine deficiency	14.36	13.53	5	35436	135	46650486
Antidepressant drug level increased	14.28	13.53	6	35435	273	46650348
Autonomic nervous system imbalance	14.25	13.53	13	35428	2413	46648208
Eosinophil count abnormal	14.18	13.53	7	35434	464	46650157
Blood pressure increased	14.15	13.53	49	35392	126617	46524004
Mental disorder due to a general medical condition	14.12	13.53	5	35436	142	46650479
Discomfort	14.11	13.53	9	35432	46661	46603960
Brain oedema	14.06	13.53	30	35411	12448	46638173
Hypomania	14.04	13.53	17	35424	4371	46646250
Echopraxia	13.94	13.53	3	35438	11	46650610
Lactate pyruvate ratio increased	13.88	13.53	4	35437	57	46650564
Mydriasis	13.82	13.53	27	35414	10526	46640095
Optic nerve disorder	13.77	13.53	8	35433	736	46649885
Aspiration of gastric residual	13.73	13.53	3	35438	12	46650609

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Neuroleptic malignant syndrome	1637.30	12.89	684	43365	15611	29892818
Extrapyramidal disorder	1488.53	12.89	568	43481	10125	29898304
Dystonia	609.95	12.89	294	43755	9433	29898996
Intentional self-injury	510.37	12.89	291	43758	13241	29895188
Agitation	486.11	12.89	492	43557	53581	29854848
Akathisia	396.09	12.89	187	43862	5717	29902712
Muscle rigidity	395.85	12.89	224	43825	10037	29898392
Psychotic disorder	371.61	12.89	284	43765	21231	29887198
Delirium	336.53	12.89	354	43695	40277	29868152
Sedation	327.26	12.89	236	43813	16137	29892292
Aggression	308.19	12.89	323	43726	36584	29871845
Weight increased	304.70	12.89	457	43592	74456	29833973
Parkinsonism	300.25	12.89	166	43883	7103	29901326
Catatonia	294.61	12.89	139	43910	4241	29904188
Tardive dyskinesia	293.34	12.89	145	43904	4912	29903517
Schizophrenia	271.58	12.89	168	43881	8880	29899549
Salivary hypersecretion	238.60	12.89	145	43904	7421	29901008
Sopor	230.10	12.89	163	43886	10828	29897601
Blood creatine phosphokinase increased	223.25	12.89	298	43751	43550	29864879
Hyperprolactinaemia	215.57	12.89	77	43972	1123	29907306
Tachycardia	193.32	12.89	370	43679	73369	29835060
Delusion	184.70	12.89	148	43901	11841	29896588
Drug interaction	184.03	12.89	677	43372	198891	29709538
Electrocardiogram QT prolonged	181.52	12.89	243	43806	35592	29872837
Suicide attempt	180.04	12.89	245	43804	36452	29871977
Hallucination, auditory	179.50	12.89	134	43915	9655	29898774
Dyskinesia	171.35	12.89	185	43864	21649	29886780
Somnolence	171.26	12.89	414	43635	96349	29812080
Intentional overdose	143.28	12.89	235	43814	41246	29867183
Hypertonia	140.71	12.89	85	43964	4300	29904129
Diarrhoea	128.69	12.89	183	43866	333920	29574509
Restlessness	128.03	12.89	162	43887	22437	29885992
Tremor	123.25	12.89	313	43736	75050	29833379
Fatigue	118.23	12.89	181	43868	320492	29587937
Dyspnoea	114.57	12.89	197	43852	333098	29575331
Embolism venous	111.99	12.89	49	44000	1248	29907181
Rhabdomyolysis	109.11	12.89	269	43780	63311	29845118
Arthralgia	105.82	12.89	34	44015	135757	29772672
Rash	105.67	12.89	77	43972	191812	29716617
Granulocytopenia	104.80	12.89	81	43968	6145	29902284
Emotional poverty	104.46	12.89	33	44016	321	29908108
Oculogyric crisis	102.91	12.89	47	44002	1328	29907101
Psychomotor hyperactivity	100.80	12.89	89	43960	8135	29900294
Coma	98.60	12.89	197	43852	40252	29868177
Oropharyngeal spasm	94.71	12.89	26	44023	146	29908283
Nausea	94.41	12.89	184	43865	296773	29611656
Serotonin syndrome	90.04	12.89	121	43928	17770	29890659
Hypothermia	89.31	12.89	89	43960	9478	29898951
Antipsychotic drug level below therapeutic	87.54	12.89	42	44007	1330	29907099
Toxicity to various agents	85.13	12.89	497	43552	176686	29731743
Headache	84.70	12.89	86	43963	182220	29726209
Dizziness	82.79	12.89	99	43950	194810	29713619
Cogwheel rigidity	82.41	12.89	38	44011	1098	29907331
Disinhibition	81.63	12.89	45	44004	1912	29906517
Altered state of consciousness	81.44	12.89	122	43927	19797	29888632
Mutism	80.52	12.89	33	44016	711	29907718
Dysphagia	78.99	12.89	222	43827	56476	29851953
Cognitive disorder	78.78	12.89	132	43917	23558	29884871
Hyperthermia	78.19	12.89	85	43964	10014	29898415
Abnormal behaviour	75.06	12.89	135	43914	25488	29882941
Obsessive-compulsive disorder	74.37	12.89	56	43993	4085	29904344
Asthenia	73.85	12.89	133	43916	221157	29687272
Anaemia	73.05	12.89	121	43928	207871	29700558
Torsade de pointes	72.92	12.89	70	43979	7120	29901309
Pneumonia aspiration	72.49	12.89	167	43882	37613	29870816
Myocardial infarction	69.61	12.89	50	43999	125575	29782854
Cardiac failure congestive	69.60	12.89	19	44030	84388	29824041
Pain in extremity	69.15	12.89	38	44011	110183	29798246
Sluggishness	68.98	12.89	48	44001	3095	29905334
Psychotic symptom	68.66	12.89	34	44015	1155	29907274
Depressed level of consciousness	67.95	12.89	164	43885	38058	29870371
Dysarthria	67.79	12.89	143	43906	30347	29878082
Treatment noncompliance	66.38	12.89	127	43922	25126	29883303
Torticollis	65.84	12.89	32	44017	1043	29907386
Pain	64.81	12.89	96	43953	172545	29735884
Incorrect route of product administration	63.88	12.89	81	43968	11234	29897195
Drooling	63.87	12.89	45	44004	2960	29905469
Cough	63.32	12.89	55	43994	125587	29782842
Opisthotonus	62.03	12.89	23	44026	375	29908054
Paranoia	60.82	12.89	75	43974	10113	29898316
Mania	60.56	12.89	71	43978	9083	29899346
Persecutory delusion	59.82	12.89	38	44011	2102	29906327
Intestinal pseudo-obstruction	58.07	12.89	30	44019	1116	29907313
Protrusion tongue	57.32	12.89	19	44030	218	29908211
Nasopharyngitis	57.24	12.89	9	44040	58840	29849589
Disorientation	57.12	12.89	136	43913	31282	29877147
Spasmodic dysphonia	56.77	12.89	15	44034	71	29908358
Confusional state	56.32	12.89	365	43684	134469	29773960
Myocarditis	55.46	12.89	71	43978	9940	29898489
Accidental exposure to product by child	54.58	12.89	32	44017	1531	29906898
Stupor	53.17	12.89	40	44009	2913	29905516
Antipsychotic drug level increased	50.70	12.89	40	44009	3126	29905303
Hallucination	50.57	12.89	173	43876	48886	29859543
White blood cell count increased	50.08	12.89	150	43899	39523	29868906
Bradykinesia	49.99	12.89	40	44009	3190	29905239
Death	49.26	12.89	316	43733	356967	29551462
Back pain	49.19	12.89	47	44002	102549	29805880
Psychomotor retardation	49.11	12.89	35	44014	2344	29906085
Pneumonia	49.03	12.89	290	43759	334016	29574413
Febrile neutropenia	48.72	12.89	51	43998	106642	29801787
Speech disorder	47.72	12.89	109	43940	24403	29884026
Psoriasis	47.55	12.89	4	44045	42502	29865927
Therapeutic product effect variable	47.35	12.89	28	44021	1361	29907068
Neuropathy peripheral	46.09	12.89	23	44026	70452	29837977
Euphoric mood	45.85	12.89	43	44006	4247	29904182
Hyperreflexia	45.74	12.89	36	44013	2803	29905626
Visceral congestion	45.18	12.89	20	44029	524	29907905
Product dose omission issue	45.07	12.89	41	44008	91590	29816839
Pruritus	45.03	12.89	65	43984	118139	29790290
Infusion related reaction	44.88	12.89	4	44045	40560	29867869
Increased appetite	44.75	12.89	48	44001	5569	29902860
Priapism	44.03	12.89	44	44005	4699	29903730
Myoclonus	44.01	12.89	74	43975	13238	29895191
Schizoaffective disorder	43.18	12.89	24	44025	1036	29907393
Bradyphrenia	42.94	12.89	40	44009	3917	29904512
Oromandibular dystonia	41.55	12.89	18	44031	447	29907982
Disturbance in attention	41.53	12.89	97	43952	22032	29886397
Cerebrovascular accident	41.47	12.89	37	44012	83440	29824989
Peripheral swelling	41.36	12.89	19	44030	61055	29847374
Social avoidant behaviour	41.24	12.89	34	44015	2829	29905600
Interstitial lung disease	40.34	12.89	19	44030	60178	29848251
Water intoxication	40.23	12.89	18	44031	484	29907945
Autonomic nervous system imbalance	39.66	12.89	31	44018	2390	29906039
Eye movement disorder	39.05	12.89	38	44011	3930	29904499
Overdose	38.71	12.89	234	43815	84103	29824326
Abdominal pain upper	38.57	12.89	22	44027	62529	29845900
Product packaging issue	37.76	12.89	17	44032	464	29907965
Ileus paralytic	37.68	12.89	44	44005	5604	29902825
Medication error	37.27	12.89	90	43959	20882	29887547
Influenza	37.23	12.89	9	44040	43389	29865040
Mental impairment	36.74	12.89	56	43993	9221	29899208
Refusal of treatment by patient	36.47	12.89	41	44008	5012	29903417
Self-injurious ideation	36.31	12.89	25	44024	1584	29906845
Pyramidal tract syndrome	36.17	12.89	13	44036	193	29908236
Chest pain	35.42	12.89	75	43974	117552	29790877
Waxy flexibility	35.10	12.89	11	44038	104	29908325
Atrial fibrillation	35.07	12.89	66	43983	108058	29800371
Mental disorder	34.55	12.89	67	43982	13382	29895047
Coronary artery disease	34.39	12.89	15	44034	49697	29858732
Joint swelling	34.37	12.89	13	44036	46933	29861496
Psychosexual disorder	33.95	12.89	10	44039	75	29908354
Trismus	33.89	12.89	28	44021	2337	29906092
Body temperature increased	33.63	12.89	70	43979	14710	29893719
Psychiatric decompensation	33.43	12.89	22	44027	1293	29907136
Tic	33.24	12.89	26	44023	2006	29906423
Urticaria	32.54	12.89	20	44029	54586	29853843
Oral discharge	32.44	12.89	11	44038	136	29908293
Dyslipidaemia	32.33	12.89	41	44008	5686	29902743
Oedema peripheral	32.26	12.89	67	43982	105765	29802664
Choking	32.11	12.89	38	44011	4908	29903521
Erythema	32.11	12.89	40	44009	77411	29831018
Colitis ischaemic	31.99	12.89	41	44008	5745	29902684
Tachypnoea	31.92	12.89	69	43980	14883	29893546
Anticholinergic syndrome	31.78	12.89	18	44031	806	29907623
Huntington's disease	31.60	12.89	9	44040	59	29908370
Rapid eye movement sleep behaviour disorder	31.05	12.89	10	44039	104	29908325
Chest discomfort	31.02	12.89	14	44035	45466	29862963
Blood prolactin abnormal	30.80	12.89	17	44032	724	29907705
Malignant catatonia	30.39	12.89	10	44039	112	29908317
Compulsive sexual behaviour	30.20	12.89	12	44037	238	29908191
Asthma	30.07	12.89	8	44041	36166	29872263
Urinary retention	29.57	12.89	111	43938	32806	29875623
Blood prolactin increased	29.54	12.89	21	44028	1401	29907028
Epistaxis	29.42	12.89	21	44028	52960	29855469
Dyspnoea exertional	29.14	12.89	8	44041	35422	29873007
Epilepsy	29.07	12.89	80	43969	20089	29888340
Delusion of grandeur	28.87	12.89	13	44036	355	29908074
Sinusitis	28.43	12.89	7	44042	33338	29875091
Patient restraint	28.35	12.89	9	44040	89	29908340
Herpes zoster	28.18	12.89	5	44044	29938	29878491
Sinus tachycardia	28.04	12.89	67	43982	15437	29892992
Angina pectoris	27.62	12.89	5	44044	29513	29878916
Decreased appetite	27.59	12.89	120	43929	149790	29758639
Prescribed overdose	27.51	12.89	47	44002	8514	29899915
Leukopenia	27.15	12.89	158	43891	56001	29852428
Injection site pain	26.56	12.89	6	44043	30304	29878125
Gastrointestinal haemorrhage	26.13	12.89	52	43997	83394	29825035
Haemorrhage	25.93	12.89	18	44031	46061	29862368
Drug level increased	25.66	12.89	72	43977	18282	29890147
Arthritis	25.45	12.89	3	44046	24398	29884031
Mental status changes	25.38	12.89	115	43934	36964	29871465
Blunted affect	25.25	12.89	11	44038	277	29908152
Drug withdrawal syndrome neonatal	25.06	12.89	27	44022	3148	29905281
Antipsychotic drug level above therapeutic	25.03	12.89	17	44032	1053	29907376
Obesity	24.94	12.89	45	44004	8510	29899919
Chorea	24.73	12.89	17	44032	1074	29907355
Hypoaesthesia	24.64	12.89	26	44023	54204	29854225
HIV peripheral neuropathy	24.43	12.89	7	44042	47	29908382
Exhibitionism	24.31	12.89	7	44042	48	29908381
Muscle contracture	24.03	12.89	17	44032	1125	29907304
Posturing	24.00	12.89	13	44036	533	29907896
Abdominal discomfort	23.77	12.89	22	44027	48769	29859660
Type 2 diabetes mellitus	23.71	12.89	58	43991	13564	29894865
Musculoskeletal pain	23.61	12.89	8	44041	30932	29877497
Acute myocardial infarction	23.37	12.89	26	44023	52913	29855516
Muscle contractions involuntary	23.36	12.89	20	44029	1753	29906676
Malaise	23.24	12.89	147	43902	166815	29741614
Disease progression	23.14	12.89	52	43997	79822	29828607
Stomatitis	23.13	12.89	13	44036	37266	29871163
Accidental exposure to product	23.12	12.89	48	44001	10067	29898362
Galactorrhoea	23.05	12.89	11	44038	344	29908085
Tension	23.01	12.89	19	44030	1584	29906845
Hallucinations, mixed	22.98	12.89	23	44026	2460	29905969
Vascular stenosis	22.91	12.89	9	44040	173	29908256
Pancytopenia	22.56	12.89	58	43991	84994	29823435
Leukocytosis	22.29	12.89	76	43973	21426	29887003
Cytomegalovirus infection	22.17	12.89	4	44045	23670	29884759
Myalgia	22.14	12.89	50	43999	76617	29831812
Gaze palsy	21.98	12.89	16	44033	1108	29907321
Fluid retention	21.80	12.89	5	44044	24993	29883436
Snoring	21.79	12.89	24	44025	2867	29905562
Aspiration	21.74	12.89	48	44001	10503	29897926
Foetal alcohol syndrome	21.66	12.89	9	44040	201	29908228
Paraesthesia	21.54	12.89	29	44020	54298	29854131
Unresponsive to stimuli	21.21	12.89	86	43963	26333	29882096
Apathy	21.07	12.89	35	44014	6197	29902232
Generalised tonic-clonic seizure	21.06	12.89	70	43979	19481	29888948
Physical assault	20.89	12.89	16	44033	1197	29907232
Intentional product use issue	20.82	12.89	14	44035	36426	29872003
Hyperkalaemia	20.77	12.89	41	44008	65969	29842460
Withdrawal syndrome	20.76	12.89	49	44000	11201	29897228
Drop attacks	20.68	12.89	12	44037	563	29907866
Thrombosis	20.62	12.89	19	44030	42212	29866217
Agranulocytosis	20.54	12.89	75	43974	21867	29886562
Inappropriate affect	20.54	12.89	12	44037	570	29907859
Sexual abuse	20.40	12.89	8	44041	153	29908276
Wheezing	20.36	12.89	10	44039	30928	29877501
Diet refusal	20.32	12.89	10	44039	335	29908094
Flight of ideas	20.00	12.89	10	44039	347	29908082
Reduced facial expression	19.71	12.89	13	44036	767	29907662
Suicidal ideation	19.71	12.89	105	43944	36009	29872420
Renal impairment	19.67	12.89	61	43988	84123	29824306
Hypokinesia	19.67	12.89	37	44012	7223	29901206
Dextrocardia	19.66	12.89	8	44041	169	29908260
Antidepressant drug level increased	19.54	12.89	7	44042	103	29908326
Weight decreased	19.42	12.89	136	43913	150785	29757644
Perseveration	19.41	12.89	7	44042	105	29908324
Antisocial behaviour	19.14	12.89	9	44040	272	29908157
Completed suicide	19.08	12.89	227	43822	99265	29809164
Speech sound disorder	19.02	12.89	6	44043	58	29908371
Sudden death	18.99	12.89	58	43991	15434	29892995
Acute kidney injury	18.99	12.89	286	43763	273556	29634873
Mydriasis	18.79	12.89	33	44016	6110	29902319
Posture abnormal	18.62	12.89	18	44031	1846	29906583
Echolalia	18.49	12.89	8	44041	198	29908231
Condition aggravated	18.47	12.89	295	43754	137571	29770858
Unevaluable event	18.44	12.89	12	44037	31773	29876656
Intentional product misuse	18.38	12.89	100	43949	34567	29873862
Thinking abnormal	18.19	12.89	30	44019	5281	29903148
Postoperative respiratory failure	18.17	12.89	6	44043	68	29908361
Encephalitis toxic	18.14	12.89	7	44042	128	29908301
Reversible splenial lesion syndrome	18.08	12.89	5	44044	29	29908400
Floppy iris syndrome	18.00	12.89	9	44040	312	29908117
Resting tremor	17.95	12.89	11	44038	571	29907858
Productive cough	17.80	12.89	11	44038	29942	29878487
Ascites	17.73	12.89	16	44033	35905	29872524
Skin lesion	17.59	12.89	3	44046	18491	29889938
Neutrophil count increased	17.52	12.89	56	43993	15267	29893162
Parkinsonian gait	17.39	12.89	10	44039	461	29907968
Inappropriate antidiuretic hormone secretion	17.15	12.89	46	44003	11376	29897053
Foetal arrhythmia	16.95	12.89	6	44043	85	29908344
Hyponatraemia	16.94	12.89	162	43887	67040	29841389
Rabbit syndrome	16.82	12.89	4	44045	11	29908418
Gender dysphoria	16.80	12.89	5	44044	39	29908390
Musculoskeletal stiffness	16.72	12.89	100	43949	35781	29872648
Primary familial brain calcification	16.57	12.89	3	44046	0	29908429
Hyperhidrosis	16.55	12.89	161	43888	66929	29841500
Dysphoria	16.48	12.89	18	44031	2130	29906299
Rhinorrhoea	16.48	12.89	5	44044	20749	29887680
Pneumonitis	16.43	12.89	10	44039	27444	29880985
Dysgeusia	16.35	12.89	8	44041	24793	29883636
Judgement impaired	16.33	12.89	11	44038	672	29907757
Cerebrovascular stenosis	16.23	12.89	6	44043	97	29908332
Hyperventilation	16.20	12.89	19	44030	2430	29905999
Irritability	16.15	12.89	72	43977	22978	29885451
Communication disorder	16.13	12.89	18	44031	2182	29906247
Colitis	16.10	12.89	13	44036	30807	29877622
Hypersexuality	16.07	12.89	15	44034	1472	29906957
Haematochezia	16.01	12.89	16	44033	34206	29874223
Myelodysplastic syndrome	15.89	12.89	4	44045	18774	29889655
Cyanosis	15.88	12.89	46	44003	11889	29896540
Malignant neoplasm progression	15.76	12.89	54	43995	72233	29836196
Mumps	15.74	12.89	6	44043	106	29908323
Electrocardiogram J wave	15.68	12.89	4	44045	16	29908413
Seizure	15.64	12.89	217	43832	98258	29810171
Nasal congestion	15.63	12.89	4	44045	18562	29889867
Haemoglobin decreased	15.58	12.89	101	43948	113997	29794432
Impaired self-care	15.57	12.89	12	44037	906	29907523
Syndactyly	15.56	12.89	11	44038	727	29907702
Sexual dysfunction	15.54	12.89	30	44019	5971	29902458
Labile blood pressure	15.21	12.89	10	44039	587	29907842
Chills	15.13	12.89	55	43994	72283	29836146
Syncope	14.97	12.89	69	43980	84834	29823595
Symptom masked	14.92	12.89	9	44040	454	29907975
Haematuria	14.85	12.89	27	44022	44807	29863622
Delusional disorder, unspecified type	14.84	12.89	11	44038	783	29907646
Hyperammonaemia	14.79	12.89	28	44021	5492	29902937
Schizoaffective disorder bipolar type	14.73	12.89	5	44044	62	29908367
Cerebral haemorrhage	14.68	12.89	16	44033	32871	29875558
Pleurothotonus	14.42	12.89	12	44037	1011	29907418
Ventricular fibrillation	14.39	12.89	52	43997	15086	29893343
Temporal lobe epilepsy	14.36	12.89	6	44043	136	29908293
Adactyly	14.31	12.89	5	44044	68	29908361
Coma scale abnormal	14.25	12.89	21	44028	3355	29905074
Visual acuity reduced	14.16	12.89	3	44046	15843	29892586
Cholelithiasis	14.15	12.89	6	44043	20219	29888210
Multiple organ dysfunction syndrome	14.13	12.89	47	44002	63440	29844989
Affective disorder	14.10	12.89	20	44029	3088	29905341
Swollen tongue	14.00	12.89	47	44002	13145	29895284
Drug-disease interaction	13.89	12.89	7	44042	247	29908182
Neuroleptic-induced deficit syndrome	13.82	12.89	4	44045	28	29908401
Differential white blood cell count abnormal	13.80	12.89	13	44036	1291	29907138
Bacteraemia	13.79	12.89	3	44046	15557	29892872
Diabetic coma	13.74	12.89	11	44038	878	29907551
Diabetes mellitus	13.73	12.89	107	43942	41758	29866671
Coprolalia	13.70	12.89	4	44045	29	29908400
Rebound effect	13.61	12.89	14	44035	1547	29906882
Hypersensitivity	13.45	12.89	38	44011	53990	29854439
Chronic obstructive pulmonary disease	13.37	12.89	30	44019	46096	29862333
Scrotal haematoma	13.35	12.89	5	44044	84	29908345
Dyslexia	13.32	12.89	6	44043	164	29908265
Substance-induced psychotic disorder	13.24	12.89	13	44036	1359	29907070
Hyporeflexia	13.19	12.89	15	44034	1857	29906572
Polydipsia	13.18	12.89	21	44028	3592	29904837
Acute psychosis	13.16	12.89	15	44034	1861	29906568
Wrong product administered	13.09	12.89	24	44025	4594	29903835
Incontinence	13.03	12.89	26	44023	5300	29903129
Renal failure	13.02	12.89	124	43925	128842	29779587
Breathing-related sleep disorder	12.96	12.89	6	44043	175	29908254
Victim of crime	12.95	12.89	7	44042	286	29908143
Paraphilia	12.93	12.89	5	44044	92	29908337
Cardio-respiratory arrest	12.91	12.89	135	43914	57171	29851258

Pharmacologic Action:

Source	Code	Description
ATC	N05AD01	NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Butyrophenone derivatives
CHEBI has role	CHEBI:48279	serotonin antagonists
CHEBI has role	CHEBI:48561	dopamine blocker
CHEBI has role	CHEBI:50919	antiemetico
CHEBI has role	CHEBI:65190	typical antipsychotic drug
CHEBI has role	CHEBI:66956	antidyskinetic drugs
MeSH PA	D018726	Anti-Dyskinesia Agents
MeSH PA	D000932	Antiemetics
MeSH PA	D014150	Antipsychotic Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D015259	Dopamine Agents
MeSH PA	D018492	Dopamine Antagonists
MeSH PA	D005765	Gastrointestinal Agents
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D014149	Tranquilizing Agents
FDA EPC	N0000180182	Typical Antipsychotic

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Gilles de la Tourette's syndrome	indication	5158005	DOID:11119
Schizophrenia	indication	58214004	DOID:5419
Psychotic disorder	indication	69322001
Chronic schizophrenia	indication	83746006
Delirium	off-label use	2776000
Nausea and vomiting	off-label use	16932000
Pain	off-label use	22253000
Anxiety disorder	off-label use	197480006	DOID:2030
Headache disorder	off-label use	230461009
Gastroparesis	off-label use	235675006
Chemotherapy-induced nausea and vomiting	off-label use	236084000
Neuroleptic malignant syndrome	contraindication	15244003	DOID:14464
Senile dementia	contraindication	15662003
Agranulocytosis	contraindication	17182001	DOID:12987
Thyrotoxic crisis	contraindication	29028009	DOID:12837
Torsades de pointes	contraindication	31722008
Parkinsonism	contraindication	32798002
Hypothyroidism	contraindication	40930008	DOID:1459
Hypokalemia	contraindication	43339004
Low blood pressure	contraindication	45007003
Extrapyramidal disease	contraindication	76349003
Leukopenia	contraindication	84828003	DOID:615
Tardive dyskinesia	contraindication	102449007
Prolonged QT interval	contraindication	111975006
Seizure disorder	contraindication	128613002
Hypomagnesemia	contraindication	190855004
Angina pectoris	contraindication	194828000
Disease of liver	contraindication	235856003	DOID:409
Retention of urine	contraindication	267064002
Neutropenic disorder	contraindication	303011007	DOID:1227
Coma	contraindication	371632003
Breastfeeding (mother)	contraindication	413712001
Central nervous system depression	contraindication	418072004
Acquired torsion dystonia	contraindication	433493000
Congenital long QT syndrome	contraindication	442917000
Carcinoma of female breast	contraindication	447782002
Smokes tobacco daily	contraindication	449868002
Drug Induced CNS Depression	contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.36	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN	INVERSE AGONIST	Ki	9.15	WOMBAT-PK	CHEMBL
Alpha-1B adrenergic receptor	GPCR	P35368	ADA1B_HUMAN		Ki	8.10	PDSP
5-hydroxytryptamine receptor 1B	GPCR	P28222	5HT1B_HUMAN		Ki	6.57	PDSP
Histamine H2 receptor	GPCR	P25021	HRH2_HUMAN		Ki	6.00	PDSP
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN		Ki	5	PDSP
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	6.26	PDSP
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	6.32	PDSP
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	5.95	PDSP
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN		Ki	6.18	PDSP
5-hydroxytryptamine receptor 1D	GPCR	P28221	5HT1D_HUMAN	ANTAGONIST	Ki	6.60	IUPHAR
Potassium voltage-gated channel subfamily H member 1	Ion channel	O95259	KCNH1_HUMAN	BLOCKER	IC50	6.20	IUPHAR
Mu-type opioid receptor	GPCR	P35372	OPRM_HUMAN		Ki	6.00	DRUG MATRIX
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	5.74	DRUG MATRIX
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN		Ki	7.55	DRUG MATRIX
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN	INVERSE AGONIST	Ki	8.52	WOMBAT-PK
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN	ANTAGONIST	Ki	7	WOMBAT-PK
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		EC50	8.92	WOMBAT-PK
Calmodulin	Cytosolic other	P0DP23 P0DP24 P0DP25	CALM1_HUMAN CALM2_HUMAN CALM3_HUMAN		IC50	6.30	WOMBAT-PK
D(1B) dopamine receptor	GPCR	P21918	DRD5_HUMAN		Ki	7.52	WOMBAT-PK
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN		Ki	7.90	WOMBAT-PK
5-hydroxytryptamine receptor 7	GPCR	P34969	5HT7R_HUMAN		Ki	6.45	WOMBAT-PK
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	6.10	WOMBAT-PK
Multidrug resistance protein 1	Transporter	P08183	MDR1_HUMAN		Ki	6.70	WOMBAT-PK
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Enzyme	Q15125	EBP_HUMAN		Ki	6.72	WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	7.50	WOMBAT-PK
D(1A) dopamine receptor	GPCR	P21728	DRD1_HUMAN		Ki	7.82	WOMBAT-PK
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN		Ki	5.55	CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III)	Ion channel	P35498 Q99250 Q9NY46	SCN1A_HUMAN SCN2A_HUMAN SCN3A_HUMAN		IC50	5.92	CHEMBL
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN		Ki	5.80	CHEMBL
5-hydroxytryptamine receptor 6	GPCR	P50406	5HT6R_HUMAN		Ki	5.22	CHEMBL
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	5.33	CHEMBL
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN		Ki	6.36	CHEMBL
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Ki	5.74	CHEMBL
5-hydroxytryptamine receptor 1E	GPCR	P28566	5HT1E_HUMAN		Ki	5.30	PDSP
5-hydroxytryptamine receptor 1F	GPCR	P30939	5HT1F_HUMAN		Ki	5.30	PDSP
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN		Ki	5.30	PDSP
D(4) dopamine receptor	GPCR	P21917	DRD4_HUMAN	INVERSE AGONIST	Kd	9.42	SCIENTIFIC LITERATURE
5-hydroxytryptamine receptor 5A	GPCR	P47898	5HT5A_HUMAN		Ki	5.65	PDSP
Alpha-1B adrenergic receptor	GPCR		ADA1B_RAT		Ki	8.31	DRUG MATRIX
Membrane-associated progesterone receptor component 1	Membrane receptor		PGRC1_RAT		Ki	7.44	DRUG MATRIX
Transporter	Transporter		Q63380_RAT		Ki	5.26	CHEMBL
Dopamine receptor	GPCR		DRD1_BOVIN DRD2_BOVIN		IC50	8.74	CHEMBL
5-hydroxytryptamine receptor 7	GPCR		5HT7R_RAT		Ki	6.58	CHEMBL
Muscarinic acetylcholine receptor	GPCR		ACM1_RAT ACM2_RAT ACM3_RAT ACM4_RAT ACM5_RAT		Ki	5.13	CHEMBL
D(2) dopamine receptor	GPCR		DRD2_BOVIN		Ki	9.52	CHEMBL
D(3) dopamine receptor	GPCR		DRD3_RAT		Ki	8.52	CHEMBL
Serotonin 2 (5-HT2) receptor	GPCR		5HT2A_RAT 5HT2B_RAT 5HT2C_RAT		Ki	8.38	CHEMBL
Dopamine receptor	GPCR		DRD1_RAT DRD2_RAT DRD3_RAT DRD4_RAT DRD5_RAT		Ki	8.70	CHEMBL
Adrenergic receptor alpha-2	GPCR		ADA2A_RAT ADA2B_RAT ADA2C_RAT		Ki	5.57	CHEMBL
Alpha-1A adrenergic receptor	GPCR		ADA1A_BOVIN		IC50	7.70	CHEMBL
AP-2 complex subunit sigma	Unclassified		AP2S1_RAT		Ki	7.62	CHEMBL
Muscarinic acetylcholine receptor M1	GPCR		ACM1_RAT		Ki	5.74	CHEMBL
Adenylate cyclase	Enzyme		ADCY2_RAT ADCY3_RAT ADCY4_RAT ADCY5_RAT ADCY6_RAT ADCY8_RAT D4A3N4_RAT Q8CFM9_RAT		IC50	5.64	CHEMBL
Muscarinic acetylcholine receptor M2	GPCR		ACM2_RAT		Ki	6.62	CHEMBL
D(3) dopamine receptor	GPCR		DRD3_CHLAE		Ki	8.52	CHEMBL
Alpha-1A adrenergic receptor	GPCR		ADA1A_RAT		Kd	7.76	CHEMBL
Serotonin 1 (5-HT1) receptor	GPCR		5HT1A_RAT 5HT1B_RAT 5HT1D_RAT 5HT1F_RAT		IC50	4.70	CHEMBL
5-hydroxytryptamine receptor 1A	GPCR		5HT1A_RAT		Ki	6.40	CHEMBL
D(1A) dopamine receptor	GPCR		DRD1_RAT		Ki	7.70	CHEMBL
Pol polyprotein	Enzyme		Q72874_9HIV1		Ki	7	CHEMBL
Histamine H1 receptor	GPCR		HRH1_RAT		Ki	6.42	CHEMBL
5-hydroxytryptamine receptor 2A	GPCR		5HT2A_PIG		Ki	7.52	CHEMBL
Opioid receptor	GPCR		OPRD_RAT OPRK_RAT OPRM_RAT SGMR1_RAT		Ki	5.92	CHEMBL
Sigma non-opioid intracellular receptor 1	Membrane receptor		SGMR1_RAT		Ki	9.05	CHEMBL
D(2) dopamine receptor	GPCR		DRD2_CHLAE		Ki	8.32	CHEMBL
Serotonin 2 (5-HT2) receptor	GPCR		5HT2A_MOUSE 5HT2B_MOUSE 5HT2C_MOUSE		Ki	7.58	CHEMBL
5-hydroxytryptamine receptor 2A	GPCR		5HT2A_BOVIN		IC50	7.52	CHEMBL
D(2) dopamine receptor	GPCR		DRD2_RAT		Ki	9.70	CHEMBL
Protease	Enzyme		Q4U254_9ENTO		Ki	7	CHEMBL
D(1A) dopamine receptor	GPCR		DRD1_PIG		Ki	7.03	CHEMBL
Sigma non-opioid intracellular receptor 1	Membrane other		SGMR1_CAVPO		Ki	9.08	CHEMBL
C-8 sterol isomerase	Enzyme		ERG2_YEAST		Ki	9.30	CHEMBL
5-hydroxytryptamine receptor 2A	GPCR		5HT2A_RAT		Ki	7.35	CHEMBL
Histamine H1 receptor	GPCR		HRH1_CAVPO		Ki	6.40	CHEMBL
5-hydroxytryptamine receptor 7	GPCR		5HT7R_MOUSE	ANTAGONIST	Ki	6.30	IUPHAR
G protein-activated inward rectifier potassium channel 2	Ion channel		KCNJ6_MOUSE	GATING INHIBITOR	EC50	4.10	IUPHAR

External reference:

ID	Source
4018123	VUID
N0000146461	NUI
D00136	KEGG_DRUG
53515-91-6	SECONDARY_CAS_RN
4018123	VANDF
4018125	VANDF
C0018546	UMLSCUI
CHEBI:5613	CHEBI
GMJ	PDB_CHEM_ID
CHEMBL54	ChEMBL_ID
CHEMBL2096643	ChEMBL_ID
CHEMBL4297147	ChEMBL_ID
DB00502	DRUGBANK_ID
3559	PUBCHEM_CID
D006220	MESH_DESCRIPTOR_UI
86	IUPHAR_LIGAND_ID
918	INN_ID
J6292F8L3D	UNII
217483	RXNORM
2958	MMSL
4816	MMSL
4818	MMSL
583	MMSL
d00027	MMSL
001518	NDDF
001521	NDDF
10756001	SNOMEDCT_US
386837002	SNOMEDCT_US
412197008	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0121-0581	SOLUTION	2 mg	ORAL	ANDA	17 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9319	INJECTION	5 mg	INTRAMUSCULAR	ANDA	16 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9501	INJECTION	5 mg	INTRAMUSCULAR	ANDA	16 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9502	INJECTION	5 mg	INTRAMUSCULAR	ANDA	16 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0214	TABLET	2 mg	ORAL	ANDA	17 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0257	TABLET	1 mg	ORAL	ANDA	17 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0327	TABLET	5 mg	ORAL	ANDA	17 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0334	TABLET	10 mg	ORAL	ANDA	17 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0335	TABLET	20 mg	ORAL	ANDA	17 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0351	TABLET	0.50 mg	ORAL	ANDA	17 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8355	TABLET	5 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1510	TABLET	0.50 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1520	TABLET	1 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1530	TABLET	2 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1540	TABLET	5 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1550	TABLET	10 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1560	TABLET	20 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-5923	TABLET	1 mg	ORAL	ANDA	18 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-5924	TABLET	2 mg	ORAL	ANDA	18 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-5925	TABLET	5 mg	ORAL	ANDA	18 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6413	TABLET	10 mg	ORAL	ANDA	18 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6661	TABLET	20 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6733	TABLET	10 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6782	TABLET	5 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7112	SOLUTION	2 mg	ORAL	ANDA	13 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	10147-0911	INJECTION	5 mg	INTRAMUSCULAR	NDA AUTHORIZED GENERIC	24 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	17478-110	INJECTION	5 mg	INTRAMUSCULAR	ANDA	22 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	17856-0501	SOLUTION	2 mg	ORAL	ANDA	13 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	17856-0581	SOLUTION, CONCENTRATE	2 mg	ORAL	ANDA	16 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	17856-0730	TABLET	5 mg	ORAL	ANDA	16 sections