All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

haloperidol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
antipsychotics, haloperidol derivatives	1353	52-86-8

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: haloperidol aloperidin haloperin sigaperidol haloperidol lactate

A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279) Molecular weight: 375.87 Formula: C21H23ClFNO2 CLOGP: 3.85 LIPINSKI: 0 HAC: 3 HDO: 1 TPSA: 40.54 ALOGS: -4.93 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
8	mg	O
8	mg	P
3.30	mg	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.04 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	1 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.57 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	65 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	17 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	7.80 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.08 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	35 hours	Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
azlogd74	LogD at pH 7.4	2.957		High	1
caco2-efflux	Caco-2 efflux ratio (BA/AB)	0.729		High	1
caco2-intrinsic-papp	Caco-2 intrinsic apparent permeability	28.445	10^-6 cm/s	High	1
dh-clint	Dog hepatocyte intrinsic clearance	16.293	uL/min/10^6 cells	High	1
dppb	Dog plasma protein binding (% unbound)	14.320	%	High	1
fcs-ppb	Fetal calf serum protein binding (% unbound)	37.710	%	High	1
herg	hERG pIC50	6.704	pIC50	High	1
hh-clint	Human hepatocyte intrinsic clearance	2.213	uL/min/10^6 cells	High	1
hlm-clint	Human liver microsomal intrinsic clearance	14.622	uL/min/mg protein	High	1
hppb	Human plasma protein binding (% unbound)	13.070	%	High	1
kinase-safety-class	ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MARK4,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK	47
kinase-selectivity-class	AKT2,AKT3,AXL,EIF2AK3,EPHB4,GRK2,PDK4,PRKCD,SIK2	9
mdck-mdr1-bcrp-efflux	MDCK-MDR1-BCRP efflux ratio	0.406		High	1
mdck-mdr1-efflux	MDCK-MDR1 efflux ratio	0.583		High	1
mh-clint	Mouse hepatocyte intrinsic clearance	25.468		High	1
mppb	Mouse plasma protein binding (% unbound)	14.460		High	1
nih-mdck-mdr1-efflux	NIH MDCK-MDR1 efflux ratio	1.690		High	1
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pld-class	Phospholipidosis risk class (1 = positive, 0 = negative)	1		High	1
pppb	Pig plasma protein binding (% unbound)	25.700	%	High	1
rat-kpuu-brain	Rat brain Kpuu	0.067	%	High	1
rh-clint	Rat hepatocyte intrinsic clearance	58.210	uL/min/10^6 cells	High	1
rh-fuinc	Rat hepatocyte fraction unbound in incubation	31.420	%	High	1
rppb	Rat plasma protein binding (% unbound)	12.780	%	High	1
solubility-dd	Solubility at pH 7.4 in DMSO	48.195	uM	High	1

Approvals:

Date	Agency	Company	Orphan
April 12, 1967	FDA	ORTHO MCNEIL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Neuroleptic malignant syndrome	2165.72	17.15	615	40277	14481	90573074
Extrapyramidal disorder	1548.25	17.15	483	40409	15820	90571735
Drug interaction	627.55	17.15	695	40197	275758	90311797
Catatonia	589.51	17.15	183	40709	5873	90581682
Intentional self-injury	573.39	17.15	275	40617	29059	90558496
Akathisia	560.38	17.15	205	40687	10954	90576601
Dystonia	512.07	17.15	215	40677	16604	90570951
Muscle rigidity	415.88	17.15	177	40715	14132	90573423
Delusion	381.80	17.15	165	40727	13675	90573880
Hyperprolactinaemia	369.09	17.15	125	40767	5308	90582247
Agitation	367.22	17.15	277	40615	66821	90520734
Psychotic disorder	353.06	17.15	203	40689	31027	90556528
Sopor	341.03	17.15	183	40709	24461	90563094
Electrocardiogram QT prolonged	333.43	17.15	270	40622	72186	90515369
Hallucination, auditory	321.92	17.15	153	40739	15822	90571733
Aggression	305.86	17.15	175	40717	26493	90561062
Psychomotor hyperactivity	293.17	17.15	134	40758	12679	90574876
Salivary hypersecretion	286.00	17.15	119	40773	8973	90578582
Tardive dyskinesia	284.19	17.15	125	40767	10805	90576750
Parkinsonism	272.12	17.15	131	40761	13934	90573621
Toxicity to various agents	250.41	17.15	458	40434	287388	90300167
Sedation	244.02	17.15	190	40702	47981	90539574
Torsade de pointes	233.46	17.15	121	40771	15061	90572494
Dyskinesia	229.53	17.15	164	40728	36370	90551185
Somnolence	220.02	17.15	362	40530	208722	90378833
Arthralgia	219.13	17.15	43	40849	778479	89809076
Hypothermia	213.61	17.15	115	40777	15460	90572095
Drug abuse	212.41	17.15	222	40670	82125	90505430
Hallucination	211.14	17.15	200	40692	65759	90521796
Schizophrenia	209.81	17.15	112	40780	14802	90572753
Joint swelling	186.44	17.15	10	40882	503290	90084265
Pain	186.12	17.15	110	40782	996231	89591324
Intentional overdose	185.27	17.15	220	40672	93614	90493941
Blood creatine phosphokinase increased	178.40	17.15	137	40755	33886	90553669
Treatment noncompliance	177.39	17.15	163	40729	51564	90535991
Delirium	175.97	17.15	226	40666	104133	90483422
Depressed level of consciousness	174.91	17.15	189	40703	72595	90514960
Suicide attempt	172.86	17.15	191	40701	75208	90512347
Tremor	171.65	17.15	273	40619	152900	90434655
Coma	157.94	17.15	179	40713	72453	90515102
Alopecia	155.62	17.15	20	40872	495051	90092504
Infusion related reaction	155.19	17.15	8	40884	416772	90170783
Swelling	153.07	17.15	9	40883	419049	90168506
Bradykinesia	152.16	17.15	70	40822	6718	90580837
Restlessness	151.44	17.15	127	40765	35593	90551962
Abdominal discomfort	143.64	17.15	22	40870	477306	90110249
Mental impairment	143.23	17.15	91	40801	16629	90570926
Psychotic symptom	141.88	17.15	49	40843	2207	90585348
Rheumatoid arthritis	141.48	17.15	5	40887	362609	90224946
Systemic lupus erythematosus	141.17	17.15	5	40887	361891	90225664
Rhabdomyolysis	139.01	17.15	142	40750	51114	90536441
Fatigue	134.50	17.15	196	40696	1153827	89433728
Abnormal behaviour	133.94	17.15	98	40794	22530	90565025
Dysarthria	130.04	17.15	141	40751	54341	90533214
Cogwheel rigidity	129.65	17.15	45	40847	2057	90585498
Overdose	129.43	17.15	245	40647	157464	90430091
Altered state of consciousness	129.32	17.15	110	40782	31422	90556133
Suicidal ideation	129.29	17.15	163	40729	73692	90513863
Rash	122.19	17.15	108	40784	795992	89791563
Pneumonia aspiration	121.28	17.15	119	40773	40821	90546734
Headache	120.87	17.15	127	40765	862619	89724936
Wound	118.80	17.15	4	40888	302976	90284579
Sinusitis	117.66	17.15	10	40882	343078	90244477
Serotonin syndrome	115.73	17.15	112	40780	37775	90549780
Nasopharyngitis	115.32	17.15	22	40870	407082	90180473
Weight increased	112.09	17.15	428	40464	417499	90170056
Pruritus	110.79	17.15	53	40839	541472	90046083
Paranoia	109.93	17.15	70	40822	12838	90574717
Pulmonary embolism	109.52	17.15	205	40687	130615	90456940
Hyponatraemia	107.75	17.15	206	40686	133332	90454223
Persecutory delusion	107.70	17.15	44	40848	3164	90584391
Pain in extremity	107.06	17.15	35	40857	450494	90137061
Tachycardia	99.78	17.15	220	40672	157453	90430102
Torticollis	99.46	17.15	39	40853	2519	90585036
Disorientation	98.05	17.15	110	40782	44004	90543551
Encephalitis autoimmune	96.62	17.15	36	40856	2022	90585533
Refusal of examination	96.53	17.15	22	40870	202	90587353
Hypertonia	93.64	17.15	46	40846	5109	90582446
Toxic epidermal necrolysis	93.46	17.15	93	40799	32435	90555120
Drug level increased	92.27	17.15	86	40806	27676	90559879
Impaired healing	92.12	17.15	3	40889	234196	90353359
Drug intolerance	91.21	17.15	44	40848	447547	90140008
Mutism	90.63	17.15	33	40859	1736	90585819
Bradyphrenia	90.06	17.15	51	40841	7561	90579994
Embolism venous	89.58	17.15	40	40852	3580	90583975
Ileus paralytic	88.28	17.15	44	40848	5041	90582514
Peripheral swelling	86.65	17.15	39	40853	413067	90174488
Oculogyric crisis	86.65	17.15	35	40857	2444	90585111
Cardiac arrest	86.02	17.15	163	40729	104772	90482783
Urinary retention	85.40	17.15	95	40797	37649	90549906
Hyperreflexia	85.29	17.15	47	40845	6610	90580945
Contraindicated product administered	85.09	17.15	20	40872	320119	90267436
Psychomotor retardation	84.80	17.15	42	40850	4747	90582808
Urticaria	84.19	17.15	19	40873	312715	90274840
Discomfort	83.93	17.15	12	40880	274323	90313232
Mania	83.20	17.15	61	40831	14063	90573492
Pericarditis	82.22	17.15	12	40880	270139	90317416
Bradycardia	81.15	17.15	140	40752	83707	90503848
Hyperthermia	80.51	17.15	53	40839	10282	90577273
Galactorrhoea	79.85	17.15	40	40852	4632	90582923
Lethargy	79.71	17.15	119	40773	63020	90524535
Hypersensitivity	79.36	17.15	54	40838	454623	90132932
Drooling	77.93	17.15	39	40853	4507	90583048
Unresponsive to stimuli	77.87	17.15	91	40801	38030	90549525
Hepatic enzyme increased	77.31	17.15	33	40859	360703	90226852
Stupor	76.62	17.15	41	40851	5441	90582114
Stereotypy	76.35	17.15	21	40871	435	90587120
Folliculitis	75.75	17.15	4	40888	204349	90383206
Myocarditis	75.45	17.15	57	40835	13749	90573806
Myoclonus	72.78	17.15	64	40828	19104	90568451
Polydipsia	71.65	17.15	36	40856	4195	90583360
Negativism	71.45	17.15	20	40872	443	90587112
Oromandibular dystonia	70.55	17.15	21	40871	582	90586973
Malignant catatonia	69.35	17.15	17	40875	219	90587336
Cognitive disorder	68.62	17.15	117	40775	69290	90518265
Osteoarthritis	66.26	17.15	6	40886	195724	90391831
Contusion	66.14	17.15	16	40876	251200	90336355
Eosinophil count decreased	65.41	17.15	31	40861	3181	90584374
Confusional state	64.57	17.15	344	40548	385861	90201694
Intentional product misuse	63.54	17.15	131	40761	89473	90498082
Arthritis	62.88	17.15	3	40889	167312	90420243
Ill-defined disorder	61.70	17.15	6	40886	184885	90402670
Mental status changes	60.43	17.15	87	40805	44592	90542963
Respiratory failure	59.42	17.15	151	40741	118267	90469288
Stomatitis	59.04	17.15	25	40867	274673	90312882
Asthma	58.91	17.15	18	40874	242142	90345413
Musculoskeletal pain	58.64	17.15	5	40887	171246	90416309
Type 2 diabetes mellitus	57.46	17.15	11	40881	203233	90384322
Behaviour disorder	57.40	17.15	32	40860	4603	90582952
Wheezing	57.37	17.15	18	40874	238062	90349493
Abdominal pain upper	57.36	17.15	40	40852	332634	90254921
Hallucination, visual	57.25	17.15	61	40831	23031	90564524
Dysphagia	57.20	17.15	144	40748	112134	90475421
Infection	56.75	17.15	48	40844	362046	90225509
Cardio-respiratory arrest	56.65	17.15	102	40790	63038	90524517
Inappropriate antidiuretic hormone secretion	56.46	17.15	56	40836	19449	90568106
Hypernatraemia	56.33	17.15	41	40851	9346	90578209
Myocardial reperfusion injury	55.95	17.15	13	40879	131	90587424
Leukopenia	55.37	17.15	133	40759	100577	90486978
Neutropenia	55.03	17.15	224	40668	224680	90362875
Psoriasis	54.41	17.15	3	40889	147751	90439804
Paraesthesia	53.44	17.15	23	40869	250303	90337252
Dyspepsia	53.38	17.15	12	40880	198148	90389407
Hypoaesthesia	52.57	17.15	39	40853	314171	90273384
Gestational diabetes	51.95	17.15	41	40851	10541	90577014
Hyperammonaemic encephalopathy	51.77	17.15	25	40867	2674	90584881
Therapeutic product effect decreased	51.07	17.15	31	40861	277540	90310015
Leukocytosis	50.44	17.15	66	40826	30924	90556631
Mental disorder	49.78	17.15	67	40825	32251	90555304
Inflammation	49.78	17.15	10	40882	178582	90408973
Apraxia	49.67	17.15	23	40869	2239	90585316
Echolalia	49.64	17.15	14	40878	319	90587236
Injury	49.21	17.15	14	40878	197335	90390220
Hypoxic-ischaemic encephalopathy	49.17	17.15	29	40863	4639	90582916
Seizure	49.03	17.15	166	40726	152463	90435092
Clonus	48.50	17.15	31	40861	5719	90581836
Hemianopia	48.32	17.15	22	40870	2060	90585495
Blood cholesterol increased	47.88	17.15	17	40875	207995	90379560
Mobility decreased	47.54	17.15	27	40865	250707	90336848
Sluggishness	47.49	17.15	31	40861	5928	90581627
Blood prolactin increased	47.48	17.15	26	40866	3611	90583944
Distractibility	46.54	17.15	15	40877	544	90587011
Waxy flexibility	45.75	17.15	11	40881	130	90587425
C-reactive protein abnormal	45.67	17.15	3	40889	127426	90460129
Hallucinations, mixed	45.39	17.15	30	40862	5859	90581696
Liver injury	44.62	17.15	11	40881	170556	90416999
Sinus bradycardia	44.20	17.15	46	40846	16906	90570649
Faecaloma	44.01	17.15	37	40855	10394	90577161
Antipsychotic drug level increased	43.84	17.15	25	40867	3754	90583801
Disturbance in attention	43.41	17.15	77	40815	47032	90540523
Lower respiratory tract infection	43.37	17.15	30	40862	250629	90336926
Poisoning	42.77	17.15	43	40849	15174	90572381
Completed suicide	42.46	17.15	153	40739	144905	90442650
Impulsive behaviour	42.44	17.15	19	40873	1711	90585844
Sexually inappropriate behaviour	41.76	17.15	10	40882	116	90587439
Refusal of treatment by patient	41.26	17.15	28	40864	5710	90581845
Hypersexuality	40.93	17.15	14	40878	612	90586943
Hyperthermia malignant	40.85	17.15	17	40875	1281	90586274
Social avoidant behaviour	40.73	17.15	23	40869	3390	90584165
Haemoglobin urine	40.43	17.15	10	40882	134	90587421
Injection site pain	40.31	17.15	14	40878	173685	90413870
Treatment failure	39.91	17.15	47	40845	303881	90283674
Chest pain	39.28	17.15	52	40840	319593	90267962
Neutrophil count increased	39.11	17.15	46	40846	19344	90568211
Speech disorder	38.81	17.15	72	40820	45513	90542042
Miosis	38.70	17.15	33	40859	9451	90578104
Withdrawal syndrome	38.26	17.15	49	40843	22475	90565080
Head titubation	37.87	17.15	16	40876	1252	90586303
Encephalopathy	37.85	17.15	72	40820	46372	90541183
Autonomic nervous system imbalance	37.83	17.15	22	40870	3428	90584127
Metabolic syndrome	37.82	17.15	18	40874	1864	90585691
Apallic syndrome	37.64	17.15	14	40878	782	90586773
Somatic symptom disorder of pregnancy	37.61	17.15	9	40883	104	90587451
Oedema	37.35	17.15	22	40870	200273	90387282
Multiple organ dysfunction syndrome	37.29	17.15	90	40802	68246	90519309
Grandiosity	37.19	17.15	11	40881	298	90587257
Cannabinoid hyperemesis syndrome	36.78	17.15	8	40884	58	90587497
Wound infection	36.72	17.15	3	40889	106399	90481156
Lung disorder	36.69	17.15	11	40881	149872	90437683
Negative symptoms in schizophrenia	36.29	17.15	9	40883	122	90587433
Feeling guilty	36.24	17.15	13	40879	655	90586900
Tonic clonic movements	36.24	17.15	17	40875	1705	90585850
Illogical thinking	36.08	17.15	8	40884	64	90587491
Dyspnoea	35.70	17.15	242	40650	880713	89706842
Dizziness	35.64	17.15	141	40751	589143	89998412
Back pain	35.61	17.15	55	40837	317120	90270435
White blood cell count increased	35.03	17.15	87	40805	67154	90520401
Sudden death	34.72	17.15	33	40859	10876	90576679
Diarrhoea	34.20	17.15	266	40626	938924	89648631
Irritability	33.77	17.15	59	40833	35603	90551952
Product dose omission issue	33.30	17.15	50	40842	291637	90295918
Dry mouth	33.22	17.15	21	40871	184038	90403517
Eosinophil count abnormal	32.95	17.15	13	40879	853	90586702
Vulvovaginal candidiasis	32.83	17.15	21	40871	3879	90583676
Hypotension	32.74	17.15	255	40637	325142	90262413
Amenorrhoea	32.72	17.15	33	40859	11689	90575866
Bronchitis	32.71	17.15	14	40878	152913	90434642
Neurotoxicity	32.30	17.15	44	40848	21423	90566132
Brain death	32.24	17.15	21	40871	4000	90583555
Mucosal dryness	31.60	17.15	19	40873	3148	90584407
Respiratory depression	31.50	17.15	37	40855	15538	90572017
Movement disorder	31.46	17.15	51	40841	28968	90558587
Red blood cells urine	31.11	17.15	11	40881	531	90587024
Nuchal rigidity	30.79	17.15	12	40880	762	90586793
Dermatitis exfoliative	30.56	17.15	23	40869	5513	90582042
Gastrooesophageal reflux disease	29.99	17.15	19	40873	166318	90421237
Schizoaffective disorder	29.79	17.15	22	40870	5125	90582430
Asthenia	29.61	17.15	132	40760	533619	90053936
Electrocardiogram PR prolongation	29.43	17.15	12	40880	858	90586697
Herpes zoster	29.25	17.15	4	40888	94640	90492915
Femoral neck fracture	28.91	17.15	29	40863	10204	90577351
Electrolyte imbalance	28.88	17.15	44	40848	23701	90563854
Blister	28.82	17.15	44	40848	254954	90332601
Euphoric mood	28.82	17.15	22	40870	5387	90582168
Nephrogenic diabetes insipidus	28.17	17.15	12	40880	958	90586597
Blood phosphorus decreased	27.98	17.15	21	40871	5013	90582542
Weight decreased	27.60	17.15	84	40808	379826	90207729
Chest discomfort	27.53	17.15	14	40878	138351	90449204
Reduced facial expression	27.25	17.15	16	40876	2537	90585018
Electroencephalogram abnormal	27.13	17.15	19	40873	4077	90583478
False positive investigation result	27.04	17.15	11	40881	782	90586773
Impaired gastric emptying	26.86	17.15	31	40861	12778	90574777
Disorganised speech	26.07	17.15	14	40878	1871	90585684
Duodenal stenosis	25.89	17.15	10	40882	620	90586935
Generalised tonic-clonic seizure	25.88	17.15	52	40840	34851	90552704
Psychiatric decompensation	25.67	17.15	14	40878	1929	90585626
Eosinophilia	25.47	17.15	46	40846	28487	90559068
Myalgia	25.28	17.15	25	40867	175100	90412455
Tachypnoea	25.24	17.15	39	40853	21270	90566285
Venous thrombosis limb	25.15	17.15	17	40875	3445	90584110
Differential white blood cell count abnormal	24.82	17.15	11	40881	967	90586588
Injection site erythema	24.52	17.15	7	40885	98495	90489060
Lactate pyruvate ratio increased	24.36	17.15	6	40886	79	90587476
Megacolon	23.96	17.15	14	40878	2200	90585355
Cough	23.75	17.15	86	40806	368876	90218679
Influenza	23.64	17.15	17	40875	139247	90448308
Urinary bladder rupture	23.52	17.15	7	40885	194	90587361
Granulocytopenia	23.44	17.15	21	40871	6420	90581135
Anticonvulsant drug level above therapeutic	23.27	17.15	9	40883	560	90586995
Urinary incontinence	23.26	17.15	52	40840	37514	90550041
Protrusion tongue	23.23	17.15	8	40884	357	90587198
Psychomotor skills impaired	23.03	17.15	15	40877	2857	90584698
Glomerular filtration rate decreased	22.93	17.15	33	40859	16899	90570656
Opisthotonus	22.77	17.15	8	40884	379	90587176
Nausea	22.60	17.15	359	40533	1109957	89477598
Hepatocellular injury	22.50	17.15	44	40848	28914	90558641
Polyglandular disorder	22.47	17.15	7	40885	227	90587328
Fluid retention	22.42	17.15	6	40886	88085	90499470
Muscle enzyme increased	22.29	17.15	7	40885	233	90587322
Gastrointestinal disorder	22.23	17.15	52	40840	256635	90330920
Muscular weakness	22.09	17.15	37	40855	206629	90380926
Brain injury	21.99	17.15	22	40870	7716	90579839
Apathy	21.95	17.15	26	40866	11014	90576541
Haematochezia	21.91	17.15	3	40889	70910	90516645
Coma scale abnormal	21.79	17.15	19	40873	5607	90581948
Stress	21.77	17.15	5	40887	81390	90506165
Delusion of reference	21.65	17.15	6	40886	128	90587427
Screaming	21.64	17.15	16	40876	3734	90583821
Croup infectious	21.63	17.15	9	40883	678	90586877
Acute kidney injury	21.46	17.15	230	40662	320157	90267398
Volvulus	21.42	17.15	13	40879	2190	90585365
Blunted affect	21.30	17.15	7	40885	270	90587285
Blood citric acid increased	21.29	17.15	5	40887	53	90587502
Electroconvulsive therapy	21.04	17.15	5	40887	56	90587499
Drug resistance	20.97	17.15	44	40848	30405	90557150
Intestinal dilatation	20.85	17.15	13	40879	2297	90585258
Grimacing	20.79	17.15	8	40884	491	90587064
Depressive symptom	20.77	17.15	18	40874	5267	90582288
Dementia	20.70	17.15	38	40854	23823	90563732
Pressure of speech	20.64	17.15	9	40883	761	90586794
Major depression	20.56	17.15	24	40868	10011	90577544
Respiratory alkalosis	20.55	17.15	15	40877	3433	90584122
Paroxysmal perceptual alteration	20.50	17.15	5	40887	63	90587492
Brief psychotic disorder with marked stressors	20.50	17.15	5	40887	63	90587492
Substance-induced psychotic disorder	20.44	17.15	14	40878	2898	90584657
Persistent postural-perceptual dizziness	20.39	17.15	4	40888	16	90587539
Dyspnoea exertional	20.23	17.15	4	40888	72284	90515271
Rash pruritic	20.18	17.15	6	40886	82208	90505347
Carnitine deficiency	19.77	17.15	6	40886	178	90587377
Sleep disorder	19.76	17.15	37	40855	197993	90389562
Acute psychosis	19.74	17.15	14	40878	3064	90584491
Muscle spasms	19.51	17.15	54	40838	251829	90335726
Resting tremor	19.46	17.15	9	40883	874	90586681
Neutrophilia	19.39	17.15	18	40874	5760	90581795
Chorea	19.36	17.15	12	40880	2098	90585457
Hypokalaemia	19.32	17.15	113	40779	131003	90456552
Ureteric obstruction	19.32	17.15	12	40880	2106	90585449
Staring	19.25	17.15	11	40881	1659	90585896
Tongue biting	19.24	17.15	12	40880	2121	90585434
Product use issue	19.24	17.15	80	40812	329839	90257716
Self-medication	19.17	17.15	14	40878	3206	90584349
Thinking abnormal	19.11	17.15	25	40867	11707	90575848
Flushing	19.08	17.15	8	40884	88483	90499072
Epileptic encephalopathy	18.98	17.15	7	40885	382	90587173
Nasal congestion	18.87	17.15	7	40885	83407	90504148
Drug reaction with eosinophilia and systemic symptoms	18.87	17.15	52	40840	42706	90544849
Akinesia	18.85	17.15	11	40881	1725	90585830
Granulomatous liver disease	18.84	17.15	9	40883	940	90586615
Hypertension	18.81	17.15	125	40767	457407	90130148
Injection site reaction	18.79	17.15	9	40883	92071	90495484
Poor personal hygiene	18.77	17.15	7	40885	394	90587161
CYP2C19 polymorphism	18.64	17.15	4	40888	27	90587528
Migraine	18.63	17.15	36	40856	190356	90397199
Muscle strength abnormal	18.59	17.15	5	40887	95	90587460
Cholecystitis	18.54	17.15	30	40862	17010	90570545
Rebound effect	18.49	17.15	22	40870	9362	90578193
Eosinophilic myocarditis	18.34	17.15	8	40884	677	90586878
Eye movement disorder	18.32	17.15	18	40874	6180	90581375
Hyperthyroidism	18.26	17.15	31	40861	18279	90569276
Hypophagia	18.19	17.15	46	40846	35891	90551664
Psychiatric symptom	17.99	17.15	19	40873	7099	90580456
Blood glucose	17.93	17.15	4	40888	33	90587522
Influenza like illness	17.85	17.15	7	40885	80604	90506951
Hyperkinesia	17.83	17.15	11	40881	1908	90585647
Foetal exposure during pregnancy	17.72	17.15	51	40841	42924	90544631
Fanconi syndrome	17.70	17.15	11	40881	1932	90585623
Flight of ideas	17.69	17.15	7	40885	463	90587092
Ventricular arrhythmia	17.56	17.15	15	40877	4306	90583249
Anger	17.51	17.15	26	40866	13694	90573861
Fall	17.51	17.15	310	40582	481500	90106055
Osteoporosis	17.43	17.15	11	40881	96520	90491035
Narcolepsy	17.41	17.15	10	40882	1522	90586033
Depressed mood	17.34	17.15	56	40836	50166	90537389
Labelled drug-food interaction medication error	17.29	17.15	6	40886	274	90587281
Arrhythmia	17.23	17.15	50	40842	42282	90545273

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Neuroleptic malignant syndrome	2294.73	14.59	909	54342	20563	42545521
Extrapyramidal disorder	1862.58	14.59	726	54525	15686	42550398
Dystonia	818.53	14.59	377	54874	12413	42553671
Akathisia	731.71	14.59	328	54923	10123	42555961
Muscle rigidity	492.76	14.59	262	54989	11797	42554287
Sedation	489.26	14.59	366	54885	30109	42535975
Catatonia	475.87	14.59	208	55043	6031	42560053
Intentional self-injury	430.96	14.59	260	54991	14942	42551142
Delirium	395.28	14.59	410	54841	52109	42513975
Tardive dyskinesia	384.04	14.59	185	55066	6739	42559345
Parkinsonism	376.28	14.59	210	55041	10413	42555671
Psychotic disorder	376.13	14.59	308	54943	28900	42537184
Weight increased	369.20	14.59	568	54683	107415	42458669
Hallucination, auditory	352.55	14.59	227	55024	14637	42551447
Agitation	345.14	14.59	421	54830	63893	42502191
Salivary hypersecretion	341.07	14.59	199	55052	10744	42555340
Hyperprolactinaemia	320.85	14.59	116	55135	2007	42564077
Delusion	286.77	14.59	199	55052	14535	42551549
Antipsychotic drug level below therapeutic	281.19	14.59	118	55133	3086	42562998
Suicide attempt	279.01	14.59	321	54930	45779	42520305
Drug interaction	260.31	14.59	848	54403	266151	42299933
Disinhibition	259.04	14.59	118	55133	3777	42562307
Obsessive-compulsive disorder	257.20	14.59	140	55111	6603	42559481
Aggression	251.38	14.59	298	54953	43865	42522219
Electrocardiogram QT prolonged	230.20	14.59	297	54954	47648	42518436
Treatment noncompliance	224.02	14.59	260	54991	37412	42528672
Sopor	223.94	14.59	164	55087	13038	42553046
Therapeutic product effect variable	218.84	14.59	98	55153	3011	42563073
Schizophrenia	215.93	14.59	147	55104	10403	42555681
Blood creatine phosphokinase increased	215.91	14.59	289	54962	48049	42518035
Tachycardia	209.24	14.59	427	54824	100660	42465424
Emotional poverty	204.03	14.59	63	55188	649	42565435
Euphoric mood	197.49	14.59	116	55135	6337	42559747
Toxicity to various agents	195.99	14.59	697	54554	228439	42337645
Increased appetite	186.81	14.59	126	55125	8780	42557304
Dyskinesia	169.25	14.59	186	55065	25204	42540880
Delusion of grandeur	166.78	14.59	71	55180	1925	42564159
Somnolence	156.26	14.59	469	54782	140636	42425448
Rhabdomyolysis	155.98	14.59	325	54926	77694	42488390
Rash	155.16	14.59	83	55168	276871	42289213
Pneumonia aspiration	155.03	14.59	252	54999	49826	42516258
Arthralgia	152.64	14.59	39	55212	205199	42360885
Hyperthermia	150.15	14.59	127	55124	12447	42553637
Priapism	147.33	14.59	96	55155	6311	42559773
Tremor	146.14	14.59	361	54890	96568	42469516
Dyspnoea	140.20	14.59	224	55027	442397	42123687
Restlessness	126.16	14.59	172	55079	29077	42537007
Psychomotor hyperactivity	125.37	14.59	108	55143	10850	42555234
Cogwheel rigidity	124.30	14.59	56	55195	1745	42564339
Headache	120.99	14.59	81	55170	239288	42326796
Diarrhoea	118.83	14.59	264	54987	460585	42105499
Fatigue	118.61	14.59	242	55009	435399	42130685
Mental impairment	116.42	14.59	109	55142	12208	42553876
Serotonin syndrome	116.06	14.59	155	55096	25690	42540394
Oculogyric crisis	112.74	14.59	52	55199	1713	42564371
Dizziness	112.30	14.59	95	55156	249159	42316925
Malignant catatonia	108.21	14.59	35	55216	424	42565660
Myocarditis	106.37	14.59	127	55124	18811	42547273
Spasmodic dysphonia	103.86	14.59	35	55216	486	42565598
Hypertonia	103.07	14.59	70	55181	4931	42561153
Altered state of consciousness	102.66	14.59	156	55095	29103	42536981
Febrile neutropenia	97.67	14.59	60	55191	185643	42380441
Dysphagia	97.28	14.59	259	54992	72460	42493624
Embolism venous	96.89	14.59	48	55203	1858	42564226
Affective disorder	96.47	14.59	72	55179	5888	42560196
Psychotic symptom	94.97	14.59	51	55200	2339	42563745
Anaemia	94.16	14.59	136	55115	280142	42285942
Coma	93.16	14.59	211	55040	53343	42512741
Rhinalgia	92.44	14.59	46	55205	1798	42564286
Intentional overdose	92.04	14.59	205	55046	51251	42514833
Hypothermia	90.96	14.59	96	55155	12419	42553665
Pain in extremity	90.46	14.59	41	55210	150563	42415521
Pain	90.17	14.59	111	55140	244737	42321347
Leukopenia	87.90	14.59	254	54997	74492	42491592
Leukaemia	87.39	14.59	67	55184	5705	42560379
Cough	86.31	14.59	63	55188	178040	42388044
Asthenia	85.97	14.59	145	55106	280648	42285436
Mania	85.87	14.59	86	55165	10461	42555623
Lymphocyte count abnormal	85.04	14.59	46	55205	2141	42563943
Nausea	83.92	14.59	251	55000	396548	42169536
Depressed level of consciousness	83.43	14.59	189	55062	47781	42518303
Overdose	81.11	14.59	310	54941	104954	42461130
Dyslipidaemia	80.77	14.59	79	55172	9339	42556745
Back pain	79.97	14.59	42	55209	141734	42424350
Hallucination	79.11	14.59	207	55044	57300	42508784
Abnormal behaviour	78.96	14.59	131	55120	26320	42539764
Schizoaffective disorder	78.17	14.59	42	55209	1928	42564156
Prescribed overdose	78.09	14.59	90	55161	12837	42553247
Product dose omission issue	76.89	14.59	53	55198	154312	42411772
Ileus paralytic	76.82	14.59	70	55181	7571	42558513
Drooling	76.51	14.59	55	55196	4244	42561840
Myoclonus	76.08	14.59	102	55149	16963	42549121
Pruritus	75.51	14.59	80	55171	188691	42377393
Blood prolactin abnormal	73.43	14.59	33	55218	1022	42565062
Dysarthria	72.77	14.59	160	55091	39647	42526437
Nasopharyngitis	72.76	14.59	11	55240	83985	42482099
Psychosexual disorder	72.73	14.59	20	55231	131	42565953
Neutrophil count increased	71.47	14.59	107	55144	19697	42546387
Persecutory delusion	71.35	14.59	49	55202	3515	42562569
Bradykinesia	69.23	14.59	57	55194	5379	42560705
Social avoidant behaviour	69.12	14.59	47	55204	3317	42562767
Oromandibular dystonia	68.87	14.59	27	55224	589	42565495
Torticollis	68.15	14.59	34	55217	1336	42564748
Cardiac failure congestive	68.07	14.59	14	55237	85588	42480496
Irritability	68.02	14.59	127	55124	28001	42538083
Protrusion tongue	67.51	14.59	21	55230	222	42565862
Myocardial infarction	66.65	14.59	39	55212	123970	42442114
Antipsychotic drug level increased	65.94	14.59	52	55199	4614	42561470
Autonomic nervous system imbalance	65.13	14.59	44	55207	3072	42563012
Paranoia	64.31	14.59	85	55166	13941	42552143
Confusional state	63.56	14.59	403	54848	167194	42398890
Cognitive disorder	63.19	14.59	138	55113	34034	42532050
Infusion related reaction	62.95	14.59	4	55247	60802	42505282
Pneumonia	62.15	14.59	309	54942	421840	42144244
Blood prolactin increased	61.74	14.59	38	55213	2260	42563824
Paroxysmal perceptual alteration	60.24	14.59	19	55232	211	42565873
Erythema	60.21	14.59	33	55218	108760	42457324
Choking	60.02	14.59	56	55195	6242	42559842
Psychomotor retardation	59.97	14.59	48	55203	4351	42561733
Hyperreflexia	59.33	14.59	44	55207	3563	42562521
Disorientation	57.38	14.59	138	55113	36251	42529833
Oropharyngeal spasm	56.90	14.59	18	55233	202	42565882
Death	56.37	14.59	369	54882	470816	42095268
Drug ineffective	56.09	14.59	1135	54116	629062	41937022
Intestinal pseudo-obstruction	54.83	14.59	35	55216	2220	42563864
Mutism	54.76	14.59	30	55221	1432	42564652
Cerebrovascular accident	52.99	14.59	30	55221	97130	42468954
Leukocytosis	52.70	14.59	118	55133	29590	42536494
Torsade de pointes	52.19	14.59	60	55191	8534	42557550
Trismus	51.56	14.59	37	55214	2847	42563237
Injection site pain	51.37	14.59	7	55244	57791	42508293
Suicidal ideation	51.22	14.59	158	55093	48003	42518081
Withdrawal syndrome	50.72	14.59	78	55173	14697	42551387
Asthma	49.93	14.59	10	55241	62304	42503780
Self-injurious ideation	47.93	14.59	30	55221	1838	42564246
Urticaria	47.90	14.59	18	55233	74018	42492066
Peripheral swelling	47.63	14.59	29	55222	90241	42475843
Obesity	47.10	14.59	80	55171	16379	42549705
Intentional product misuse	46.57	14.59	181	55070	61719	42504365
Speech disorder	46.52	14.59	111	55140	29010	42537074
Sinusitis	46.42	14.59	4	55247	47288	42518796
Bruxism	46.23	14.59	31	55220	2138	42563946
Oscillopsia	45.92	14.59	16	55235	247	42565837
Rebound effect	45.62	14.59	52	55199	7327	42558757
Joint swelling	44.92	14.59	16	55235	68006	42498078
Resting tremor	44.43	14.59	23	55228	978	42565106
Stupor	44.26	14.59	35	55216	3118	42562966
Epistaxis	43.65	14.59	16	55235	66810	42499274
White blood cell count increased	43.46	14.59	143	55108	44944	42521140
Eye movement disorder	43.37	14.59	42	55209	4903	42561181
Rheumatoid arthritis	43.31	14.59	3	55248	42437	42523647
Drug withdrawal syndrome	43.27	14.59	90	55161	21459	42544625
Completed suicide	42.95	14.59	242	55009	96223	42469861
Visceral congestion	42.86	14.59	22	55229	919	42565165
Influenza	42.13	14.59	14	55237	62161	42503923
Interstitial lung disease	41.68	14.59	25	55226	78437	42487647
Encephalitis toxic	41.35	14.59	15	55236	262	42565822
Cardio-respiratory arrest	41.33	14.59	168	55083	58468	42507616
Waxy flexibility	41.12	14.59	12	55239	100	42565984
Sexual dysfunction	40.63	14.59	47	55204	6728	42559356
Chest discomfort	40.27	14.59	16	55235	63600	42502484
Sedation complication	40.11	14.59	32	55219	2887	42563197
Arthritis	40.10	14.59	4	55247	42061	42524023
Urinary retention	39.89	14.59	133	55118	42081	42524003
Hyperventilation	39.76	14.59	33	55218	3149	42562935
Intentional product use issue	39.42	14.59	22	55229	71811	42494273
Thrombosis	39.04	14.59	20	55231	68491	42497593
Water intoxication	38.64	14.59	16	55235	404	42565680
Abdominal discomfort	38.56	14.59	25	55226	75230	42490854
Wrong patient received product	38.33	14.59	34	55217	3549	42562535
Refusal of treatment by patient	37.40	14.59	40	55211	5251	42560833
Peptostreptococcus infection	37.12	14.59	10	55241	60	42566024
Coronary artery disease	36.57	14.59	12	55239	53708	42512376
Herpes zoster	36.28	14.59	4	55247	38873	42527211
Seizure	36.25	14.59	274	54977	120287	42445797
Dry skin	36.22	14.59	9	55242	48329	42517755
Inappropriate schedule of product administration	35.73	14.59	43	55208	95859	42470225
Myelosuppression	35.72	14.59	5	55246	40456	42525628
Mental status changes	34.86	14.59	127	55124	41988	42524096
Nephrogenic diabetes insipidus	34.76	14.59	23	55228	1551	42564533
Decreased appetite	34.64	14.59	131	55120	193006	42373078
Tic	34.63	14.59	27	55224	2356	42563728
Inappropriate antidiuretic hormone secretion	34.28	14.59	70	55181	16471	42549613
Paraesthesia	34.24	14.59	27	55224	73432	42492652
Haemorrhage	34.03	14.59	18	55233	60545	42505539
Neglect of personal appearance	33.71	14.59	14	55237	356	42565728
Hypoaesthesia	33.64	14.59	26	55225	71437	42494647
SARS-CoV-2 test positive	33.24	14.59	47	55204	8213	42557871
Oedema peripheral	33.23	14.59	80	55171	135996	42430088
Oral discharge	32.69	14.59	11	55240	152	42565932
Granulocytopenia	32.44	14.59	43	55208	7071	42559013
Bradyphrenia	32.39	14.59	37	55214	5225	42560859
Opisthotonus	32.32	14.59	16	55235	618	42565466
Sinus tachycardia	32.20	14.59	78	55173	20575	42545509
Product packaging issue	32.18	14.59	17	55234	754	42565330
Anticholinergic syndrome	32.17	14.59	22	55229	1567	42564517
Porphyria acute	32.13	14.59	14	55237	402	42565682
Tachypnoea	31.86	14.59	80	55171	21582	42544502
Atrial fibrillation	31.81	14.59	85	55166	139508	42426576
Ascites	31.62	14.59	17	55234	56661	42509423
Huntington's disease	30.92	14.59	8	55243	40	42566044
Thinking abnormal	30.69	14.59	42	55209	7119	42558965
Patient restraint	30.53	14.59	9	55242	78	42566006
Compulsive sexual behaviour	30.39	14.59	12	55239	267	42565817
Prostate cancer	30.34	14.59	10	55241	44633	42521451
Chest pain	30.28	14.59	87	55164	139443	42426641
Lymphocyte count decreased	30.27	14.59	92	55159	27717	42538367
Drug level increased	29.77	14.59	88	55163	26112	42539972
Apathy	29.73	14.59	45	55206	8361	42557723
Pancytopenia	29.72	14.59	68	55183	117675	42448409
Chronic obstructive pulmonary disease	29.66	14.59	23	55228	63091	42502993
Tension	29.64	14.59	25	55226	2439	42563645
Blunted affect	29.50	14.59	13	55238	384	42565700
Weight decreased	29.47	14.59	154	55097	207794	42358290
Schizoaffective disorder bipolar type	29.28	14.59	10	55241	145	42565939
Cardiac arrest	28.77	14.59	241	55010	109079	42457005
Faecaloma	28.74	14.59	38	55213	6232	42559852
Posturing	28.57	14.59	14	55237	529	42565555
Generalised tonic-clonic seizure	28.46	14.59	87	55164	26292	42539792
Dysgeusia	28.42	14.59	5	55246	34184	42531900
Substance-induced psychotic disorder	28.13	14.59	26	55225	2863	42563221
Disturbance in attention	28.13	14.59	94	55157	29772	42536312
Dextrocardia	27.93	14.59	8	55243	62	42566022
Haematochezia	27.84	14.59	21	55230	58415	42507669
Nasal congestion	27.62	14.59	3	55248	29498	42536586
Colitis ischaemic	27.44	14.59	40	55211	7186	42558898
Mental disorder	26.95	14.59	67	55184	17962	42548122
Angina pectoris	26.94	14.59	5	55246	32891	42533193
Stomatitis	26.78	14.59	16	55235	50313	42515771
Self-destructive behaviour	26.66	14.59	12	55239	373	42565711
Antipsychotic drug level above therapeutic	26.52	14.59	18	55233	1266	42564818
Psoriasis	26.50	14.59	15	55236	48589	42517495
Postoperative respiratory failure	26.44	14.59	9	55242	129	42565955
Cytomegalovirus infection	26.27	14.59	5	55246	32301	42533783
Malignant neoplasm progression	26.24	14.59	64	55187	108336	42457748
Pyramidal tract syndrome	25.95	14.59	11	55240	295	42565789
Colitis	25.93	14.59	14	55237	46558	42519526
Abdominal pain upper	25.82	14.59	42	55209	82567	42483517
Cholinergic syndrome	25.77	14.59	14	55237	657	42565427
Foetal alcohol syndrome	25.77	14.59	8	55243	84	42566000
Wheezing	25.70	14.59	20	55231	54761	42511323
Body temperature increased	25.68	14.59	71	55180	20287	42545797
Blood pressure increased	25.61	14.59	59	55192	101869	42464215
Musculoskeletal pain	25.39	14.59	6	55245	33334	42532750
Muscle contractions involuntary	25.21	14.59	21	55230	2013	42564071
Bronchitis	25.12	14.59	15	55236	47186	42518898
Acute myocardial infarction	25.12	14.59	23	55228	58142	42507942
Sluggishness	25.01	14.59	28	55223	3868	42562216
Hyperammonaemia	24.88	14.59	40	55211	7826	42558258
Symptom masked	24.77	14.59	15	55236	866	42565218
Chorea	24.62	14.59	18	55233	1426	42564658
Labile blood pressure	24.44	14.59	14	55237	729	42565355
Hypersensitivity	24.34	14.59	35	55216	72335	42493749
Drug ineffective for unapproved indication	24.07	14.59	121	55130	46042	42520042
Exhibitionism	23.92	14.59	7	55244	59	42566025
Multiple organ dysfunction syndrome	23.71	14.59	57	55194	96978	42469106
Red blood cell sedimentation rate decreased	23.70	14.59	10	55241	265	42565819
Colitis ulcerative	23.66	14.59	3	55248	26172	42539912
Vascular stenosis	23.59	14.59	9	55242	182	42565902
Gout	23.55	14.59	4	55247	28051	42538033
HIV peripheral neuropathy	23.53	14.59	6	55245	28	42566056
Pharyngeal dystonia	23.51	14.59	7	55244	63	42566021
Therapeutic product effect incomplete	23.47	14.59	165	55086	70774	42495310
Intestinal obstruction	23.41	14.59	83	55168	27075	42539009
Hyperkalaemia	23.23	14.59	43	55208	80415	42485669
Gastrointestinal disorder	23.22	14.59	16	55235	46637	42519447
Condition aggravated	23.10	14.59	470	54781	260284	42305800
Sudden death	22.99	14.59	60	55191	16569	42549515
Abdominal pain	22.74	14.59	149	55102	190322	42375762
Muscle contracture	22.48	14.59	17	55234	1418	42564666
Rapid eye movement sleep behaviour disorder	22.39	14.59	10	55241	305	42565779
Loss of personal independence in daily activities	22.35	14.59	19	55232	49797	42516287
Hyponatraemia	22.25	14.59	215	55036	101247	42464837
Blood pressure fluctuation	22.23	14.59	4	55247	26904	42539180
Sexual abuse	22.09	14.59	8	55243	139	42565945
Pulmonary fibrosis	21.97	14.59	4	55247	26677	42539407
Polydipsia	21.82	14.59	28	55223	4460	42561624
Chills	21.63	14.59	57	55194	94009	42472075
Fluid retention	21.63	14.59	7	55244	31612	42534472
Psychiatric decompensation	21.57	14.59	27	55224	4195	42561889
Reduced facial expression	21.48	14.59	17	55234	1516	42564568
Haemoptysis	21.47	14.59	17	55234	46150	42519934
Coma scale abnormal	21.44	14.59	28	55223	4537	42561547
Sexually inappropriate behaviour	21.19	14.59	12	55239	611	42565473
Acute kidney injury	21.15	14.59	342	54909	366995	42199089
Haemoglobin decreased	21.14	14.59	94	55157	132377	42433707
Patient elopement	21.00	14.59	8	55243	161	42565923
Wolff-Parkinson-White syndrome	20.97	14.59	9	55242	249	42565835
Rectal haemorrhage	20.97	14.59	20	55231	49586	42516498
Hallucinations, mixed	20.88	14.59	24	55227	3411	42562673
Respiratory alkalosis	20.73	14.59	20	55231	2324	42563760
Hostility	20.72	14.59	13	55238	800	42565284
Galactorrhoea	20.69	14.59	11	55240	494	42565590
Antipsychotic drug level decreased	20.63	14.59	15	55236	1178	42564906
Encephalopathy	20.61	14.59	107	55144	41226	42524858
Drug abuse	20.56	14.59	217	55034	104554	42461530
Migraine	20.52	14.59	4	55247	25410	42540674
Hyperhidrosis	20.44	14.59	193	55058	90319	42475765
Penis disorder	20.31	14.59	16	55235	1417	42564667
Dyspnoea exertional	20.30	14.59	21	55230	50127	42515957
Acute psychosis	20.27	14.59	19	55232	2130	42563954
Pneumocystis jirovecii pneumonia	20.25	14.59	4	55247	25177	42540907
Illusion	20.25	14.59	14	55237	1015	42565069
Renal impairment	20.24	14.59	74	55177	110154	42455930
Cross sensitivity reaction	20.16	14.59	17	55234	1658	42564426
Perseveration	20.09	14.59	7	55244	108	42565976
Infection	20.08	14.59	76	55175	111992	42454092
Chronic kidney disease	20.02	14.59	19	55232	47222	42518862
Psychiatric symptom	19.90	14.59	26	55225	4215	42561869
Pneumonitis	19.86	14.59	15	55236	41703	42524381
Behaviour disorder	19.80	14.59	34	55217	7020	42559064
Gastric infection	19.52	14.59	16	55235	1500	42564584
Diet refusal	19.36	14.59	9	55242	302	42565782
Eczema	19.34	14.59	10	55241	34076	42532008
Olfactory nerve disorder	19.24	14.59	6	55245	64	42566020
Antisocial behaviour	19.23	14.59	10	55241	429	42565655
Parkinsonian gait	19.23	14.59	11	55240	571	42565513
Nephrolithiasis	19.18	14.59	12	55239	36818	42529266
Miosis	19.09	14.59	49	55202	13397	42552687
Upper respiratory tract infection	19.02	14.59	16	55235	42157	42523927
Gastrointestinal haemorrhage	19.02	14.59	64	55187	97662	42468422
Floppy iris syndrome	19.00	14.59	9	55242	315	42565769
Heart rate decreased	18.90	14.59	12	55239	36520	42529564
Resuscitation	18.89	14.59	17	55234	1808	42564276
Cataract	18.87	14.59	8	55243	30596	42535488
Delusional disorder, unspecified type	18.68	14.59	12	55239	769	42565315
Urinary incontinence	18.49	14.59	66	55185	21602	42544482
Epilepsy	18.44	14.59	75	55176	26096	42539988
Pulmonary hypertension	18.43	14.59	4	55247	23565	42542519
Anaphylactic shock	18.37	14.59	4	55247	23513	42542571
Incorrect route of product administration	18.21	14.59	71	55180	24234	42541850
Full blood count abnormal	18.12	14.59	8	55243	29868	42536216
Anxiety	18.12	14.59	234	55017	118326	42447758
Speech sound disorder	18.10	14.59	7	55244	147	42565937
Akinesia	18.02	14.59	19	55232	2453	42563631
Hypersexuality	17.91	14.59	16	55235	1686	42564398
Rabbit syndrome	17.66	14.59	5	55246	37	42566047
Pancreatitis	17.64	14.59	18	55233	43250	42522834
Abdominal distension	17.63	14.59	42	55209	71693	42494391
Osteoarthritis	17.42	14.59	5	55246	24400	42541684
Nuchal rigidity	17.36	14.59	10	55241	526	42565558
Physical assault	17.35	14.59	13	55238	1069	42565015
Disease progression	17.33	14.59	112	55139	143544	42422540
Swelling	17.05	14.59	28	55223	54857	42511227
Oropharyngeal pain	16.98	14.59	18	55233	42492	42523592
Gastrooesophageal reflux disease	16.96	14.59	20	55231	45003	42521081
Therapy interrupted	16.95	14.59	4	55247	22246	42543838
Mumps	16.91	14.59	6	55245	98	42565986
Pica	16.89	14.59	5	55246	44	42566040
Gender dysphoria	16.89	14.59	5	55246	44	42566040
Staring	16.89	14.59	15	55236	1568	42564516
Localised infection	16.89	14.59	3	55248	20370	42545714
Unresponsive to stimuli	16.85	14.59	83	55168	31320	42534764
Unevaluable event	16.75	14.59	12	55239	34276	42531808
Brain injury	16.58	14.59	33	55218	7622	42558462
Negativism	16.57	14.59	9	55242	422	42565662
Sepsis	16.46	14.59	172	55079	199162	42366922
Blood insulin abnormal	16.39	14.59	4	55247	15	42566069
Malaise	16.35	14.59	186	55065	211970	42354114
Intensive care	16.21	14.59	13	55238	1181	42564903
Skin exfoliation	16.15	14.59	18	55233	41535	42524549
Cerebrovascular stenosis	16.07	14.59	6	55245	114	42565970
Posture abnormal	15.98	14.59	18	55233	2503	42563581
Osmotic demyelination syndrome	15.87	14.59	12	55239	1000	42565084
Haematuria	15.72	14.59	32	55219	57767	42508317
Cyanosis	15.68	14.59	49	55202	14982	42551102
Syncope	15.57	14.59	71	55180	99335	42466749
Hypophosphataemia	15.50	14.59	4	55247	20941	42545143
Incontinence	15.47	14.59	30	55221	6800	42559284
Flight of ideas	15.46	14.59	8	55243	340	42565744
Skin discolouration	15.44	14.59	4	55247	20886	42545198
Productive cough	15.38	14.59	27	55224	51540	42514544
Muscular weakness	15.36	14.59	56	55195	83442	42482642
Slow speech	15.32	14.59	15	55236	1775	42564309
Foetal arrhythmia	15.21	14.59	6	55245	133	42565951
Appendicitis	15.13	14.59	4	55247	20609	42545475
Antisocial personality disorder	15.07	14.59	5	55246	66	42566018
Accidental exposure to product by child	15.06	14.59	14	55237	1553	42564531
Photopsia	15.03	14.59	17	55234	2375	42563709
Transient ischaemic attack	14.97	14.59	13	55238	33726	42532358
Compulsions	14.94	14.59	7	55244	239	42565845
Bradycardia	14.91	14.59	173	55078	85311	42480773
Kleefstra syndrome	14.87	14.59	3	55248	3	42566081
Rash pruritic	14.85	14.59	13	55238	33590	42532494
Diplopia	14.80	14.59	4	55247	20312	42545772
Bacteraemia	14.73	14.59	7	55244	25033	42541051
Injection site erythema	14.67	14.59	4	55247	20191	42545893
Dyspnoea paroxysmal nocturnal	14.66	14.59	14	55237	1606	42564478
Neuropathy peripheral	14.65	14.59	75	55176	101778	42464306
Bacterial infection	14.64	14.59	9	55242	27870	42538214
Vasculitis	14.63	14.59	3	55248	18391	42547693
Mydriasis	14.62	14.59	34	55217	8736	42557348
Echolalia	14.62	14.59	8	55243	381	42565703
Illness	14.62	14.59	7	55244	24923	42541161

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Neuroleptic malignant syndrome	4426.49	15.01	1459	84658	32600	110470582
Extrapyramidal disorder	3306.64	15.01	1125	84992	27742	110475440
Dystonia	1262.17	15.01	541	85576	25264	110477918
Catatonia	1056.72	15.01	379	85738	10921	110492261
Akathisia	1033.16	15.01	417	85700	16696	110486486
Intentional self-injury	991.64	15.01	514	85603	36915	110466267
Muscle rigidity	921.89	15.01	425	85692	23606	110479576
Drug interaction	830.91	15.01	1434	84683	498749	110004433
Agitation	729.38	15.01	645	85472	112406	110390776
Psychotic disorder	656.96	15.01	439	85678	50498	110452684
Hallucination, auditory	652.04	15.01	346	85771	26051	110477131
Delusion	634.17	15.01	328	85789	23427	110479755
Sedation	632.64	15.01	485	85632	69198	110433984
Parkinsonism	620.20	15.01	316	85801	21871	110481311
Salivary hypersecretion	618.22	15.01	292	85825	17129	110486053
Tardive dyskinesia	615.77	15.01	270	85847	13309	110489873
Hyperprolactinaemia	608.93	15.01	219	85898	6356	110496826
Aggression	541.58	15.01	414	85703	58796	110444386
Delirium	523.78	15.01	584	85533	134441	110368741
Sopor	520.01	15.01	335	85782	36211	110466971
Electrocardiogram QT prolonged	481.64	15.01	505	85612	108455	110394727
Toxicity to various agents	405.00	15.01	1045	85072	479510	110023672
Psychomotor hyperactivity	404.84	15.01	231	85886	20046	110483136
Blood creatine phosphokinase increased	397.15	15.01	379	85738	72698	110430484
Arthralgia	396.36	15.01	66	86051	779566	109723616
Dyskinesia	377.15	15.01	316	85801	51130	110452052
Somnolence	364.40	15.01	750	85367	296699	110206483
Rhabdomyolysis	358.23	15.01	455	85662	119946	110383236
Treatment noncompliance	336.28	15.01	346	85771	72644	110430538
Suicide attempt	330.39	15.01	405	85712	102989	110400193
Schizophrenia	330.16	15.01	208	85909	21618	110481564
Weight increased	327.33	15.01	887	85230	418757	110084425
Tremor	312.69	15.01	563	85554	201669	110301513
Tachycardia	301.96	15.01	592	85525	226053	110277129
Pneumonia aspiration	298.87	15.01	342	85775	80891	110422291
Pain	294.80	15.01	191	85926	954764	109548418
Hypothermia	281.00	15.01	202	85915	26100	110477082
Hallucination	273.14	15.01	365	85752	101067	110402115
Joint swelling	262.91	15.01	22	86095	442823	110060359
Restlessness	259.68	15.01	267	85850	55992	110447190
Hyperthermia	254.28	15.01	175	85942	21097	110482085
Infusion related reaction	253.39	15.01	10	86107	381152	110122030
Headache	253.03	15.01	191	85926	882186	109620996
Rash	252.13	15.01	165	85952	820799	109682383
Cogwheel rigidity	247.08	15.01	97	86020	3601	110499581
Depressed level of consciousness	235.94	15.01	359	85758	111919	110391263
Torsade de pointes	233.29	15.01	170	85947	22430	110480752
Intentional overdose	229.57	15.01	388	85729	132113	110371069
Serotonin syndrome	227.69	15.01	255	85862	58898	110444284
Fatigue	224.59	15.01	377	85740	1215581	109287601
Altered state of consciousness	219.38	15.01	247	85870	57379	110445803
Coma	210.64	15.01	350	85767	117519	110385663
Mental impairment	208.44	15.01	159	85958	22480	110480702
Nasopharyngitis	205.45	15.01	31	86086	394330	110108852
Bradykinesia	204.92	15.01	119	85998	10669	110492513
Abnormal behaviour	203.58	15.01	198	85919	38841	110464341
Rheumatoid arthritis	202.06	15.01	7	86110	299606	110203576
Pain in extremity	202.01	15.01	64	86053	487054	110016128
Emotional poverty	199.15	15.01	60	86057	980	110502202
Hypertonia	198.56	15.01	107	86010	8299	110494883
Delusion of grandeur	197.01	15.01	72	86045	2188	110500994
Malignant catatonia	194.28	15.01	54	86063	652	110502530
Dysarthria	193.97	15.01	281	85836	83840	110419342
Priapism	188.94	15.01	92	86025	5769	110497413
Embolism venous	186.83	15.01	87	86030	4936	110498246
Overdose	185.77	15.01	498	85619	233296	110269886
Suicidal ideation	185.63	15.01	292	85825	93645	110409537
Myocarditis	184.69	15.01	167	85950	29888	110473294
Psychotic symptom	182.15	15.01	79	86038	3788	110499394
Sinusitis	180.90	15.01	13	86104	296675	110206507
Swelling	179.65	15.01	29	86088	351012	110152170
Abdominal discomfort	179.63	15.01	43	86074	393815	110109367
Oculogyric crisis	179.57	15.01	78	86039	3754	110499428
Pruritus	179.54	15.01	116	86001	581444	109921738
Systemic lupus erythematosus	178.67	15.01	4	86113	254334	110248848
Dysphagia	178.10	15.01	379	85738	153221	110349961
Ileus paralytic	177.86	15.01	112	86005	11625	110491557
Arthropathy	171.34	15.01	14	86103	287508	110215674
Drug abuse	170.24	15.01	406	85711	177005	110326177
Peripheral swelling	165.85	15.01	54	86063	403980	110099202
Mania	165.44	15.01	134	85983	20662	110482520
Torticollis	162.24	15.01	69	86048	3152	110500030
Persecutory delusion	159.65	15.01	84	86033	6207	110496975
Disorientation	157.02	15.01	232	85885	70439	110432743
Urticaria	153.07	15.01	31	86086	318826	110184356
Paranoia	150.78	15.01	131	85986	22243	110480939
Antipsychotic drug level below therapeutic	150.22	15.01	55	86062	1680	110501502
Dyspnoea	145.52	15.01	414	85703	1106458	109396724
Myoclonus	143.98	15.01	152	85965	32846	110470336
Psychomotor retardation	142.84	15.01	84	86033	7708	110495474
Wound	140.83	15.01	11	86106	234426	110268756
Hyperreflexia	139.95	15.01	89	86028	9396	110493786
Dizziness	139.41	15.01	205	85912	697988	109805194
Hypersensitivity	138.25	15.01	71	86046	403927	110099255
Drooling	136.26	15.01	79	86038	7060	110496122
Mutism	134.98	15.01	60	86057	3053	110500129
Intentional product misuse	131.64	15.01	308	85809	132596	110370586
Impaired healing	131.20	15.01	5	86112	196712	110306470
Disinhibition	128.22	15.01	58	86059	3076	110500106
Schizoaffective disorder	128.18	15.01	58	86059	3078	110500104
Obsessive-compulsive disorder	127.35	15.01	76	86041	7165	110496017
Asthma	125.09	15.01	22	86095	250269	110252913
Diarrhoea	122.91	15.01	465	85652	1139040	109364142
Leukocytosis	121.43	15.01	178	85939	53650	110449532
Neutrophil count increased	120.86	15.01	142	85975	34510	110468672
Urinary retention	120.55	15.01	204	85913	69479	110433703
Cognitive disorder	120.52	15.01	232	85885	87279	110415903
Social avoidant behaviour	120.31	15.01	66	86051	5303	110497879
Irritability	119.48	15.01	166	85951	47643	110455539
Oromandibular dystonia	118.13	15.01	42	86075	1177	110502005
Osteoarthritis	117.33	15.01	6	86111	182617	110320565
Cardiac arrest	116.87	15.01	378	85739	196375	110306807
Leukopenia	116.14	15.01	315	85802	148476	110354706
Contraindicated product administered	115.33	15.01	26	86091	248241	110254941
Drug level increased	115.25	15.01	163	85954	47556	110455626
Alopecia	114.87	15.01	71	86046	364682	110138500
Nausea	114.27	15.01	535	85582	1235155	109268027
Hyponatraemia	112.41	15.01	399	85718	217254	110285928
Musculoskeletal pain	111.59	15.01	8	86109	183015	110320167
Confusional state	110.59	15.01	683	85434	467997	110035185
Autonomic nervous system imbalance	110.42	15.01	64	86053	5716	110497466
Stomatitis	109.30	15.01	37	86080	270205	110232977
Arthritis	109.28	15.01	5	86112	167581	110335601
Euphoric mood	108.75	15.01	74	86043	8753	110494429
Mental status changes	106.29	15.01	203	85914	75919	110427263
Folliculitis	106.16	15.01	6	86111	167647	110335535
Stupor	105.92	15.01	71	86046	8194	110494988
Spasmodic dysphonia	105.07	15.01	32	86085	543	110502639
Hypoaesthesia	104.85	15.01	57	86060	314166	110189016
Cardio-respiratory arrest	104.55	15.01	259	85858	115577	110387605
Abdominal pain upper	104.43	15.01	72	86045	349039	110154143
Asthenia	103.97	15.01	240	85877	688759	109814423
Back pain	103.88	15.01	82	86035	370914	110132268
Bradyphrenia	100.61	15.01	79	86038	11649	110491533
Wheezing	99.70	15.01	37	86080	255193	110247989
Lymphocyte count abnormal	99.57	15.01	45	86072	2381	110500801
Affective disorder	99.21	15.01	77	86040	11164	110492018
Seizure	98.80	15.01	387	85730	220798	110282384
Paraesthesia	98.49	15.01	46	86071	276475	110226707
Blood prolactin increased	98.36	15.01	55	86062	4587	110498595
Drug intolerance	98.18	15.01	103	86014	406409	110096773
Ill-defined disorder	98.14	15.01	6	86111	156847	110346335
Cough	94.54	15.01	133	85984	461508	110041674
Discomfort	91.08	15.01	27	86090	214680	110288502
Completed suicide	90.95	15.01	402	85715	241979	110261203
Hepatic enzyme increased	89.73	15.01	71	86046	320821	110182361
Antipsychotic drug level increased	89.27	15.01	60	86057	6955	110496227
Inappropriate antidiuretic hormone secretion	88.29	15.01	120	85997	33731	110469451
Speech disorder	88.19	15.01	166	85951	61403	110441779
Injection site pain	88.10	15.01	16	86101	177906	110325276
Bursitis	87.67	15.01	3	86114	129915	110373267
C-reactive protein abnormal	87.50	15.01	3	86114	129692	110373490
Night sweats	87.35	15.01	4	86113	133979	110369203
Galactorrhoea	84.70	15.01	48	86069	4107	110499075
Inflammation	84.37	15.01	23	86094	193215	110309967
Bradycardia	83.64	15.01	289	85828	155228	110347954
Encephalitis autoimmune	83.58	15.01	45	86072	3483	110499699
Paroxysmal perceptual alteration	83.57	15.01	23	86094	267	110502915
Withdrawal syndrome	82.99	15.01	112	86005	31268	110471914
Therapeutic product effect variable	82.64	15.01	41	86076	2677	110500505
Refusal of examination	82.38	15.01	22	86095	226	110502956
Lethargy	82.09	15.01	207	85910	93369	110409813
Sluggishness	80.54	15.01	58	86059	7509	110495673
Protrusion tongue	80.04	15.01	25	86092	463	110502719
Product dose omission issue	79.41	15.01	80	86037	321702	110181480
Rhinalgia	79.05	15.01	45	86072	3884	110499298
Negativism	78.77	15.01	29	86088	900	110502282
Waxy flexibility	78.23	15.01	22	86095	278	110502904
Mobility decreased	77.84	15.01	44	86073	237378	110265804
Polydipsia	77.45	15.01	57	86060	7631	110495551
Drug withdrawal syndrome	76.12	15.01	119	85998	37935	110465247
Unresponsive to stimuli	75.73	15.01	159	85958	63631	110439551
Increased appetite	74.41	15.01	74	86043	14903	110488279
Drug ineffective	73.65	15.01	1622	84495	1518918	108984264
Faecaloma	72.85	15.01	73	86044	14835	110488347
Contusion	72.63	15.01	46	86071	233315	110269867
Pericarditis	71.26	15.01	41	86076	219073	110284109
Psychosexual disorder	70.88	15.01	18	86099	149	110503033
Mental disorder	70.33	15.01	116	86001	38675	110464507
Behaviour disorder	70.13	15.01	59	86058	9588	110493594
Therapeutic product effect decreased	69.62	15.01	53	86064	244263	110258919
Infection	67.71	15.01	111	86006	362089	110141093
Lower respiratory tract infection	67.68	15.01	54	86063	243052	110260130
Refusal of treatment by patient	66.83	15.01	57	86060	9437	110493745
White blood cell count increased	66.71	15.01	196	85921	96646	110406536
Intestinal pseudo-obstruction	66.35	15.01	38	86079	3318	110499864
Disturbance in attention	66.14	15.01	148	85969	61847	110441335
Chest pain	66.10	15.01	120	85997	376255	110126927
Injury	65.44	15.01	28	86089	177237	110325945
Echolalia	65.05	15.01	22	86095	529	110502653
Pulmonary embolism	64.66	15.01	334	85783	214140	110289042
Gastrointestinal disorder	64.57	15.01	56	86061	241896	110261286
Influenza	63.57	15.01	26	86091	169075	110334107
Pulmonary fibrosis	63.54	15.01	4	86113	102038	110401144
Chest discomfort	63.32	15.01	28	86089	173820	110329362
Herpes zoster	62.57	15.01	6	86111	108373	110394809
Gastrooesophageal reflux disease	62.45	15.01	31	86086	179945	110323237
Psoriasis	62.36	15.01	16	86101	139977	110363205
Self-injurious ideation	62.18	15.01	40	86077	4306	110498876
Stereotypy	62.10	15.01	25	86092	992	110502190
Hallucination, visual	62.04	15.01	111	86006	39494	110463688
Oedema	61.84	15.01	44	86073	209932	110293250
Granulocytopenia	61.65	15.01	62	86055	12653	110490529
Encephalopathy	61.62	15.01	170	85947	80885	110422297
Tachypnoea	61.18	15.01	110	86007	39285	110463897
Hallucinations, mixed	60.80	15.01	52	86065	8641	110494541
Blood cholesterol increased	59.48	15.01	35	86082	184750	110318432
Miosis	58.96	15.01	79	86038	21904	110481278
Visceral congestion	58.56	15.01	26	86091	1319	110501863
Resting tremor	58.42	15.01	28	86089	1695	110501487
Liver injury	58.39	15.01	22	86095	150391	110352791
Generalised tonic-clonic seizure	57.72	15.01	130	85987	54550	110448632
Bronchitis	57.65	15.01	25	86092	157007	110346175
Opisthotonus	57.42	15.01	22	86095	764	110502418
Sudden death	56.94	15.01	82	86035	24313	110478869
Hyperammonaemic encephalopathy	56.35	15.01	41	86076	5393	110497789
Rebound effect	55.53	15.01	63	86054	14743	110488439
Lung disorder	55.32	15.01	36	86081	180011	110323171
Oropharyngeal spasm	55.26	15.01	19	86098	481	110502701
Myelosuppression	55.05	15.01	5	86112	94335	110408847
Erythema	54.75	15.01	89	86028	291358	110211824
Nephrogenic diabetes insipidus	54.63	15.01	30	86087	2415	110500767
Thinking abnormal	54.39	15.01	63	86054	15077	110488105
Substance-induced psychotic disorder	54.16	15.01	40	86077	5384	110497798
Hypernatraemia	52.35	15.01	67	86050	17766	110485416
Malaise	52.25	15.01	308	85809	671511	109831671
Wound infection	51.53	15.01	7	86110	96458	110406724
Respiratory failure	51.42	15.01	315	85802	215017	110288165
Choking	51.16	15.01	61	86056	15049	110488133
Intentional product use issue	51.12	15.01	71	86046	247835	110255347
Clonus	50.75	15.01	47	86070	8669	110494513
Migraine	50.50	15.01	36	86081	171616	110331566
Neutropenia	50.46	15.01	479	85638	374141	110129041
Drug hypersensitivity	50.23	15.01	183	85934	453907	110049275
Oscillopsia	50.02	15.01	17	86100	415	110502767
Blunted affect	49.85	15.01	18	86099	528	110502654
Electrocardiogram J wave	48.89	15.01	12	86105	85	110503097
Myocardial reperfusion injury	48.81	15.01	13	86104	132	110503050
Type 2 diabetes mellitus	48.53	15.01	40	86077	177192	110325990
Dyslipidaemia	48.47	15.01	61	86056	15904	110487278
Weight decreased	48.31	15.01	194	85923	467863	110035319
Colitis ulcerative	48.26	15.01	3	86114	77360	110425822
Eye movement disorder	48.21	15.01	48	86069	9680	110493502
Nuchal rigidity	47.88	15.01	22	86095	1210	110501972
Sexual dysfunction	47.74	15.01	45	86072	8485	110494697
Muscular weakness	47.49	15.01	75	86042	248393	110254789
Trismus	47.25	15.01	40	86077	6556	110496626
Blood prolactin abnormal	46.89	15.01	32	86085	3803	110499379
Apraxia	46.78	15.01	31	86086	3509	110499673
Hyperhidrosis	46.63	15.01	277	85840	187021	110316161
Colitis ischaemic	46.40	15.01	63	86054	17687	110485495
Hyperthermia malignant	46.40	15.01	32	86085	3868	110499314
Nasal congestion	46.21	15.01	10	86107	98272	110404910
Reduced facial expression	45.91	15.01	31	86086	3620	110499562
Fluid retention	45.57	15.01	9	86108	94298	110408884
Injection site erythema	45.48	15.01	9	86108	94167	110409015
Cardiac failure congestive	45.30	15.01	31	86086	150969	110352213
Anaemia	45.12	15.01	246	85871	546840	109956342
Oedema peripheral	44.39	15.01	121	85996	328539	110174643
Chorea	44.38	15.01	29	86088	3206	110499976
Product packaging issue	44.36	15.01	23	86094	1648	110501534
Injection site reaction	44.10	15.01	8	86109	89062	110414120
Febrile neutropenia	44.01	15.01	115	86002	316652	110186530
Lower limb fracture	43.95	15.01	4	86113	75344	110427838
Encephalitis toxic	43.63	15.01	14	86103	284	110502898
Feeling guilty	43.49	15.01	19	86098	927	110502255
Blister	43.10	15.01	69	86048	227307	110275875
Apathy	43	15.01	58	86059	16181	110487001
Coma scale abnormal	42.77	15.01	45	86072	9681	110493501
Toxic epidermal necrolysis	42.15	15.01	118	85999	56609	110446573
Neurotoxicity	41.96	15.01	98	86019	42109	110461073
Huntington's disease	41.95	15.01	8	86109	12	110503170
Brain injury	41.73	15.01	52	86065	13424	110489758
Epistaxis	41.52	15.01	25	86092	130347	110372835
Dry mouth	41.48	15.01	57	86060	199891	110303291
Bruxism	41.46	15.01	33	86084	4961	110498221
Dry skin	41.36	15.01	16	86101	107637	110395545
Poisoning	41.08	15.01	78	86039	29027	110474155
Sinus tachycardia	40.67	15.01	100	86017	44393	110458789
Hyperventilation	40.43	15.01	42	86075	8905	110494277
Rapid eye movement sleep behaviour disorder	40.03	15.01	16	86101	623	110502559
Tic	40.01	15.01	28	86089	3465	110499717
Road traffic accident	39.57	15.01	17	86100	107381	110395801
Respiratory alkalosis	39.56	15.01	34	86083	5687	110497495
Psychiatric decompensation	39.33	15.01	34	86083	5731	110497451
Sexually inappropriate behaviour	39.27	15.01	16	86101	655	110502527
Impulsive behaviour	38.97	15.01	27	86090	3288	110499894
Tension	38.87	15.01	32	86085	5046	110498136
Blood pressure increased	38.87	15.01	90	86027	258283	110244899
Osteoporosis	38.74	15.01	10	86107	87142	110416040
Hypersexuality	38.44	15.01	22	86095	1918	110501264
Patient restraint	38.24	15.01	10	86107	94	110503088
Grandiosity	38.02	15.01	15	86102	564	110502618
Muscle spasms	37.12	15.01	103	86014	278054	110225128
Anticholinergic syndrome	37.08	15.01	29	86088	4251	110498931
Haematochezia	37.00	15.01	22	86095	115502	110387680
Drug ineffective for unapproved indication	36.60	15.01	168	85949	102670	110400512
Hyperammonaemia	36.29	15.01	49	86068	13683	110489499
Eosinophil count decreased	36.10	15.01	33	86084	5985	110497197
Oral discharge	36.07	15.01	12	86105	274	110502908
Compulsive sexual behaviour	35.78	15.01	12	86105	281	110502901
Gestational diabetes	35.77	15.01	36	86081	7353	110495829
Pyramidal tract syndrome	35.68	15.01	16	86101	831	110502351
Sinus bradycardia	35.58	15.01	74	86043	29409	110473773
Parotitis	35.47	15.01	25	86092	3128	110500054
Illness	35.44	15.01	10	86107	82161	110421021
Diet refusal	35.38	15.01	16	86101	848	110502334
Illogical thinking	35.17	15.01	9	86108	77	110503105
Differential white blood cell count abnormal	35.12	15.01	22	86095	2262	110500920
Parkinsonian gait	35.07	15.01	17	86100	1055	110502127
Wrong patient received product	35.06	15.01	34	86083	6640	110496542
Red blood cell sedimentation rate increased	34.77	15.01	9	86108	78293	110424889
Akinesia	34.29	15.01	26	86091	3641	110499541
Psychiatric symptom	34.21	15.01	39	86078	9174	110494008
Posturing	34.19	15.01	17	86100	1115	110502067
Haemoglobin urine	34.04	15.01	10	86107	149	110503033
Cataract	33.68	15.01	10	86107	79475	110423707
Floppy iris syndrome	33.56	15.01	12	86105	342	110502840
Hyporesponsive to stimuli	32.93	15.01	23	86094	2837	110500345
Somatic symptom disorder of pregnancy	32.82	15.01	9	86108	103	110503079
Interstitial lung disease	32.82	15.01	36	86081	139298	110363884
Penis disorder	32.69	15.01	16	86101	1014	110502168
Burning sensation	32.62	15.01	7	86110	69205	110433977
Peptostreptococcus infection	32.60	15.01	10	86107	174	110503008
Respiratory depression	32.57	15.01	75	86042	31926	110471256
Metabolic syndrome	32.54	15.01	24	86093	3223	110499959
Rash pruritic	32.37	15.01	18	86099	98051	110405131
Tonic clonic movements	32.27	15.01	23	86094	2929	110500253
Drug resistance	32.25	15.01	107	86010	56267	110446915
Distractibility	31.64	15.01	15	86102	886	110502296
Cerebrovascular accident	31.62	15.01	58	86059	181226	110321956
Maternal exposure during pregnancy	31.38	15.01	98	86019	254785	110248397
Antipsychotic drug level above therapeutic	31.36	15.01	21	86096	2419	110500763
Head titubation	31.29	15.01	17	86100	1340	110501842
Slow speech	31.26	15.01	24	86093	3424	110499758
Decreased appetite	30.98	15.01	230	85887	475616	110027566
Water intoxication	30.75	15.01	15	86102	944	110502238
Staring	30.40	15.01	22	86095	2870	110500312
Flight of ideas	29.93	15.01	14	86103	802	110502380
Muscle contractions involuntary	29.90	15.01	26	86091	4418	110498764
Cannabinoid hyperemesis syndrome	29.88	15.01	8	86109	83	110503099
Upper respiratory tract infection	29.77	15.01	35	86082	131293	110371889
Hepatocellular injury	29.76	15.01	97	86020	50545	110452637
Electroencephalogram abnormal	29.75	15.01	30	86087	6143	110497039
Intestinal obstruction	29.54	15.01	100	86017	53127	110450055
Urinary incontinence	29.40	15.01	94	86023	48493	110454689
Self-destructive behaviour	29.31	15.01	14	86103	841	110502341
Dementia with Lewy bodies	29.25	15.01	15	86102	1051	110502131
Acute psychosis	29.24	15.01	27	86090	4960	110498222
Sedation complication	29.01	15.01	54	86063	19801	110483381
Delusional disorder, unspecified type	28.76	15.01	14	86103	877	110502305
Speech sound disorder	28.72	15.01	7	86110	48	110503134
Stress	28.56	15.01	24	86093	105324	110397858
Mydriasis	28.38	15.01	57	86060	22100	110481082
Throat irritation	28.33	15.01	4	86113	53548	110449634
Hemianopia	28.30	15.01	21	86096	2847	110500335
Drug diversion	28.29	15.01	16	86101	1364	110501818
Flushing	28.22	15.01	24	86093	104712	110398470
Neglect of personal appearance	28.15	15.01	11	86106	403	110502779
Dyspnoea exertional	27.85	15.01	24	86093	104036	110399146
Illusion	27.55	15.01	18	86099	1989	110501193
Agranulocytosis	27.49	15.01	108	86009	61652	110441530
Schizoaffective disorder bipolar type	27.45	15.01	10	86107	301	110502881
Loss of consciousness	27.39	15.01	253	85864	196053	110307129
Eczema	27.35	15.01	11	86106	72282	110430900
Hypoxic-ischaemic encephalopathy	27.17	15.01	34	86083	8813	110494369
Communication disorder	27.09	15.01	26	86091	5013	110498169
Poor personal hygiene	27.06	15.01	12	86105	607	110502575
Myalgia	27.02	15.01	86	86031	222295	110280887
Negative symptoms in schizophrenia	26.83	15.01	9	86108	211	110502971
Postoperative respiratory failure	26.63	15.01	9	86108	216	110502966
Megacolon	26.60	15.01	24	86093	4281	110498901
Somatic hallucination	26.56	15.01	7	86110	68	110503114
Muscle contracture	26.46	15.01	20	86097	2788	110500394
Pneumonia	26.24	15.01	503	85614	876211	109626971
Granulomatous liver disease	26.24	15.01	16	86101	1568	110501614
Liver disorder	26.17	15.01	44	86073	142199	110360983
Pressure of speech	26.11	15.01	15	86102	1317	110501865
Cholinergic syndrome	26.11	15.01	15	86102	1317	110501865
Treatment failure	26.06	15.01	119	85998	277115	110226067
Symptom masked	26.03	15.01	17	86100	1878	110501304
Intestinal dilatation	26.02	15.01	22	86095	3598	110499584
SARS-CoV-2 test positive	25.93	15.01	47	86070	16888	110486294
Apallic syndrome	25.90	15.01	14	86103	1092	110502090
Injection site swelling	25.77	15.01	8	86109	61782	110441400
Vulvovaginal candidiasis	25.77	15.01	21	86096	3264	110499918
Myocardial infarction	25.71	15.01	71	86046	192012	110311170
Feeling hot	25.64	15.01	20	86097	91086	110412096
HIV peripheral neuropathy	25.60	15.01	6	86111	34	110503148
Dry eye	25.58	15.01	6	86111	55787	110447395
Blepharospasm	24.94	15.01	6	86111	54845	110448337
Compulsions	24.53	15.01	10	86107	410	110502772
Pregnancy	24.41	15.01	5	86112	51062	110452120
Hallucination, olfactory	24.32	15.01	11	86106	583	110502599
Blood pressure fluctuation	24.31	15.01	14	86103	74810	110428372
Hypercholesterolaemia	24.25	15.01	21	86096	90816	110412366
Accidental exposure to product by child	24.16	15.01	20	86097	3178	110500004
Olfactory nerve disorder	24.15	15.01	6	86111	45	110503137
Live birth	24.05	15.01	12	86105	69472	110433710
Eosinophilia	23.94	15.01	99	86018	57837	110445345
Multiple sclerosis relapse	23.84	15.01	5	86112	50235	110452947
Neck pain	23.67	15.01	37	86080	123093	110380089
Dementia	23.64	15.01	66	86051	31607	110471575
Haemorrhage	23.58	15.01	29	86088	106663	110396519
Resuscitation	23.54	15.01	19	86098	2914	110500268
Circadian rhythm sleep disorder	23.53	15.01	13	86104	1059	110502123
Eosinophil count abnormal	23.51	15.01	13	86104	1061	110502121
Anaphylactic reaction	23.28	15.01	33	86084	114267	110388915
Cardiomyopathy alcoholic	23.28	15.01	6	86111	53	110503129
Grimacing	23.17	15.01	12	86105	858	110502324
Aspiration	23.16	15.01	64	86053	30469	110472713
Hypokinesia	23.15	15.01	52	86065	21774	110481408
Impaired gastric emptying	23.13	15.01	39	86078	13236	110489946
Red blood cells urine	23.09	15.01	11	86106	657	110502525
Gaze palsy	23.06	15.01	20	86097	3387	110499795
Brain death	23.02	15.01	27	86090	6546	110496636
Drop attacks	22.91	15.01	13	86104	1115	110502067
Cytomegalovirus infection	22.80	15.01	7	86110	54437	110448745
Hostility	22.78	15.01	18	86099	2678	110500504
Patient elopement	22.70	15.01	9	86108	343	110502839
Psychotic behaviour	22.60	15.01	14	86103	1411	110501771
Haemodynamic instability	22.59	15.01	53	86064	22835	110480347
Gait inability	22.58	15.01	45	86072	136331	110366851
Coronary artery disease	22.47	15.01	14	86103	71676	110431506
Diverticulitis	22.20	15.01	7	86110	53515	110449667
Oropharyngeal pain	22.09	15.01	45	86072	135231	110367951
Abdominal pain	21.88	15.01	275	85842	512714	109990468
Delusion of reference	21.77	15.01	8	86109	247	110502935
Electrocardiogram PR prolongation	21.64	15.01	15	86102	1828	110501354
Lactate pyruvate ratio increased	21.62	15.01	6	86111	72	110503110
Rhinorrhoea	21.55	15.01	29	86088	102637	110400545
Ventricular fibrillation	21.52	15.01	76	86041	41237	110461945
Psychomotor skills impaired	21.48	15.01	27	86090	7031	110496151
Lymphocyte count decreased	21.48	15.01	95	86022	57148	110446034
Ear infection	21.46	15.01	11	86106	62721	110440461
Blood phosphorus decreased	21.25	15.01	28	86089	7637	110495545
Wolff-Parkinson-White syndrome	21.24	15.01	9	86108	407	110502775
Inappropriate schedule of product administration	21.23	15.01	84	86033	203553	110299629
Palpitations	21.19	15.01	59	86058	159153	110344029
Blood pressure systolic increased	21.18	15.01	20	86097	82971	110420211
Poverty of speech	21.09	15.01	10	86107	591	110502591
Heart rate decreased	21.05	15.01	20	86097	82736	110420446
Perseveration	21.02	15.01	9	86108	418	110502764
Physical assault	20.89	15.01	14	86103	1614	110501568
Memory impairment	20.69	15.01	81	86036	196863	110306319
Laryngitis	20.59	15.01	4	86113	42407	110460775
Basal cell carcinoma	20.49	15.01	5	86112	45265	110457917
Product quality issue	20.47	15.01	18	86099	77281	110425901
Full blood count abnormal	20.45	15.01	9	86108	56043	110447139
Screaming	20.43	15.01	22	86095	4859	110498323
Dyspepsia	20.41	15.01	78	86039	190887	110312295
Inappropriate affect	20.35	15.01	14	86103	1685	110501497
Dysphoria	20.22	15.01	25	86092	6403	110496779
Antipsychotic drug level decreased	20.21	15.01	13	86104	1399	110501783
Osmotic demyelination syndrome	20.12	15.01	15	86102	2048	110501134
Pancreatitis	20.07	15.01	26	86091	93507	110409675
Body temperature increased	19.92	15.01	90	86027	54623	110448559
Pituitary tumour benign	19.85	15.01	17	86100	2830	110500352
Nervous system disorder	19.77	15.01	62	86055	31659	110471523
Disorganised speech	19.60	15.01	18	86099	3285	110499897
Drug reaction with eosinophilia and systemic symptoms	19.51	15.01	120	85997	81975	110421207
Sleep disorder	19.43	15.01	84	86033	198560	110304622
Femoral neck fracture	19.39	15.01	35	86082	12532	110490650
Cyanosis	19.34	15.01	59	86058	29682	110473500
Abdominal distension	19.05	15.01	71	86046	175032	110328150
Localised infection	19.01	15.01	5	86112	43043	110460139
Movement disorder	18.99	15.01	67	86050	36337	110466845
Loss of personal independence in daily activities	18.94	15.01	57	86060	149963	110353219
Dysgeusia	18.90	15.01	16	86101	69969	110433213
Amenorrhoea	18.64	15.01	29	86088	9202	110493980
Blood citric acid increased	18.58	15.01	5	86112	53	110503129
Posture abnormal	18.57	15.01	20	86097	4418	110498764
Chills	18.39	15.01	81	86036	190499	110312683
Polyglandular disorder	18.38	15.01	7	86110	239	110502943
Tachyphrenia	18.35	15.01	15	86102	2341	110500841
Echopraxia	18.33	15.01	5	86112	56	110503126
Immunodeficiency	18.16	15.01	4	86113	38834	110464348
Nephrolithiasis	18.05	15.01	15	86102	66197	110436985
Procedural pain	18.03	15.01	3	86114	35562	110467620
Tongue spasm	17.95	15.01	6	86111	139	110503043
Accidental overdose	17.94	15.01	84	86033	51750	110451432
Antidepressant drug level increased	17.87	15.01	9	86108	607	110502575
Gender dysphoria	17.87	15.01	5	86112	62	110503120
Thrombosis	17.86	15.01	36	86081	108626	110394556
Exhibitionism	17.79	15.01	5	86112	63	110503119
Depressive symptom	17.79	15.01	27	86090	8387	110494795
False positive investigation result	17.77	15.01	12	86105	1402	110501780
Labile blood pressure	17.73	15.01	15	86102	2456	110500726
Skin discolouration	17.69	15.01	8	86109	49038	110454144
Dyspnoea paroxysmal nocturnal	17.57	15.01	15	86102	2487	110500695
Mucosal dryness	17.47	15.01	19	86098	4244	110498938
Antisocial personality disorder	17.37	15.01	5	86112	69	110503113
Product use issue	17.36	15.01	157	85960	311538	110191644
Limb injury	17.35	15.01	4	86113	37632	110465550
Cataplexy	17.32	15.01	11	86106	1158	110502024
Metabolic acidosis	17.32	15.01	135	85982	99609	110403573
Device issue	17.32	15.01	3	86114	34532	110468650
Haemoptysis	17.28	15.01	18	86099	71336	110431846
Impaired self-care	17.25	15.01	15	86102	2549	110500633
Ulcer	17.25	15.01	6	86111	43110	110460072
Fungal infection	17.24	15.01	9	86108	50797	110452385
Leukaemia	17.15	15.01	25	86092	7493	110495689
Eating disorder	17.14	15.01	58	86059	30800	110472382
Pneumocystis jirovecii pneumonia	17.00	15.01	6	86111	42729	110460453
Vascular dementia	16.99	15.01	10	86107	919	110502263
Hypoparathyroidism	16.91	15.01	12	86105	1518	110501664
Cerebrovascular stenosis	16.88	15.01	6	86111	168	110503014
Transient ischaemic attack	16.82	15.01	15	86102	63967	110439215
Scrotal haematoma	16.81	15.01	5	86112	78	110503104
Gastrointestinal haemorrhage	16.80	15.01	69	86048	165449	110337733
Logorrhoea	16.76	15.01	20	86097	4937	110498245
Myxoedema coma	16.76	15.01	9	86108	693	110502489
Hyperphagia	16.72	15.01	17	86100	3514	110499668
Paraphilia	16.63	15.01	5	86112	81	110503101
Urinary tract infection	16.62	15.01	168	85949	326114	110177068
Hypoxia	16.61	15.01	164	85953	129351	110373831
Anger	16.61	15.01	42	86075	18965	110484217
Incoherent	16.52	15.01	26	86091	8332	110494850
Duodenal stenosis	16.52	15.01	10	86107	967	110502215
Kleefstra syndrome	16.40	15.01	3	86114	3	110503179
Drug-induced liver injury	16.35	15.01	44	86073	120023	110383159
Hyperkinesia	16.31	15.01	16	86101	3168	110500014
Visual impairment	16.31	15.01	52	86065	134376	110368806
Eye swelling	16.29	15.01	3	86114	33045	110470137
Wrong product administered	16.25	15.01	30	86087	10930	110492252
Anaphylactic shock	16.25	15.01	10	86107	51536	110451646
Neutrophilia	16.24	15.01	29	86088	10300	110492882
Laboratory test abnormal	16.20	15.01	7	86110	44072	110459110
Self-medication	16.11	15.01	22	86095	6210	110496972
Pica	16.09	15.01	5	86112	91	110503091
Surgery	16.08	15.01	6	86111	41277	110461905
Soliloquy	16.06	15.01	10	86107	1017	110502165
Paradoxical drug reaction	16.00	15.01	28	86089	9789	110493393
Haematuria	15.90	15.01	25	86092	82980	110420202
Vascular stenosis	15.89	15.01	9	86108	769	110502413
Labelled drug-food interaction medication error	15.78	15.01	6	86111	204	110502978
Electroconvulsive therapy	15.74	15.01	5	86112	98	110503084
Drug screen false positive	15.74	15.01	11	86106	1358	110501824
Condition aggravated	15.72	15.01	711	85406	734125	109769057
Visual acuity reduced	15.69	15.01	3	86114	32170	110471012
Swelling face	15.68	15.01	30	86087	92291	110410891
Polyneuropathy	15.58	15.01	3	86114	32009	110471173
Pleurothotonus	15.58	15.01	14	86103	2484	110500698
Prostate cancer	15.47	15.01	5	86112	37636	110465546
Device dislocation	15.37	15.01	3	86114	31701	110471481
Borderline personality disorder	15.33	15.01	10	86107	1102	110502080
Therapy interrupted	15.24	15.01	10	86107	49812	110453370
Product use in unapproved indication	15.20	15.01	456	85661	446921	110056261
Blood insulin abnormal	15.07	15.01	4	86113	40	110503142
Fear	15.07	15.01	46	86071	23147	110480035
Therapy partial responder	15.05	15.01	63	86054	36998	110466184

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05AD01	NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Butyrophenone derivatives
MeSH PA	D000932	Antiemetics
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D005765	Gastrointestinal Agents
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D014150	Antipsychotic Agents
MeSH PA	D015259	Dopamine Agents
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018492	Dopamine Antagonists
MeSH PA	D018726	Anti-Dyskinesia Agents
CHEBI has role	CHEBI:35469	antidepressant
CHEBI has role	CHEBI:35474	anxiolytic drug
CHEBI has role	CHEBI:35480	analgesic
CHEBI has role	CHEBI:48279	serotonergic antagonist
CHEBI has role	CHEBI:48561	dopaminergic antagonist
CHEBI has role	CHEBI:50919	antiemetic
CHEBI has role	CHEBI:65190	first generation antipsychotic
CHEBI has role	CHEBI:66956	antidyskinesia agent
FDA EPC	N0000180182	Typical Antipsychotic
CHEBI has role	CHEBI:35476	antipsychotic agent

Related Drugs by ATC class:

N05AD Butyrophenone derivatives 8 drugs

benperidolbromperidoldroperidollumateperonemelperonemoperonepipamperonetrifluperidol

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Gilles de la Tourette's syndrome	indication	5158005	DOID:11119
Schizophrenia	indication	58214004	DOID:5419
Psychotic disorder	indication	69322001
Chronic schizophrenia	indication	83746006
Delirium	off-label use	2776000
Nausea and vomiting	off-label use	16932000
Pain	off-label use	22253000
Anxiety disorder	off-label use	197480006	DOID:2030
Headache disorder	off-label use	230461009
Gastroparesis	off-label use	235675006
Chemotherapy-induced nausea and vomiting	off-label use	236084000
Neuroleptic malignant syndrome	contraindication	15244003	DOID:14464
Senile dementia	contraindication	15662003
Agranulocytosis	contraindication	17182001	DOID:12987
Thyrotoxic crisis	contraindication	29028009	DOID:12837
Torsades de pointes	contraindication	31722008
Parkinsonism	contraindication	32798002
Hypothyroidism	contraindication	40930008	DOID:1459
Hypokalemia	contraindication	43339004
Low blood pressure	contraindication	45007003
Extrapyramidal disease	contraindication	76349003
Leukopenia	contraindication	84828003	DOID:615
Tardive dyskinesia	contraindication	102449007
Prolonged QT interval	contraindication	111975006
Seizure disorder	contraindication	128613002
Hypomagnesemia	contraindication	190855004
Angina pectoris	contraindication	194828000
Disease of liver	contraindication	235856003	DOID:409
Retention of urine	contraindication	267064002
Neutropenic disorder	contraindication	303011007	DOID:1227
Coma	contraindication	371632003
Breastfeeding (mother)	contraindication	413712001
Central nervous system depression	contraindication	418072004
Acquired torsion dystonia	contraindication	433493000
Congenital long QT syndrome	contraindication	442917000
Carcinoma of female breast	contraindication	447782002
Smokes tobacco daily	contraindication	449868002
Drug Induced CNS Depression	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.36	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN	INVERSE AGONIST	Ki	9.15		WOMBAT-PK	CHEMBL
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN		Ki	5.30		PDSP
Mu-type opioid receptor	GPCR	P35372	OPRM_HUMAN		Ki	6.00		DRUG MATRIX
D(1A) dopamine receptor	GPCR	P21728	DRD1_HUMAN		Ki	7.82		WOMBAT-PK
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	5.95		PDSP
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		EC50	8.92		WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	7.50		WOMBAT-PK
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Enzyme	Q15125	EBP_HUMAN		Ki	6.72		WOMBAT-PK
Multidrug resistance protein 1	Transporter	P08183	MDR1_HUMAN		Ki	6.70		WOMBAT-PK
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Ki	5.74		CHEMBL
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	5.74		DRUG MATRIX
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN		Ki	5.55		CHEMBL
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN	ANTAGONIST	Ki	7		WOMBAT-PK
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	6.10		WOMBAT-PK
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	5.33		CHEMBL
5-hydroxytryptamine receptor 6	GPCR	P50406	5HT6R_HUMAN		Ki	5.22		CHEMBL
5-hydroxytryptamine receptor 7	GPCR	P34969	5HT7R_HUMAN		Ki	6.45		WOMBAT-PK
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN		Ki	7.90		WOMBAT-PK
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	6.32		PDSP
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN	INVERSE AGONIST	Ki	8.52		WOMBAT-PK
D(1B) dopamine receptor	GPCR	P21918	DRD5_HUMAN		Ki	7.52		WOMBAT-PK
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN		Ki	6.36		CHEMBL
Histamine H2 receptor	GPCR	P25021	HRH2_HUMAN		Ki	6.00		PDSP
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN		Ki	5.80		CHEMBL
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN		Ki	5		PDSP
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN		Ki	6.18		PDSP
5-hydroxytryptamine receptor 1B	GPCR	P28222	5HT1B_HUMAN		Ki	6.57		PDSP
5-hydroxytryptamine receptor 1D	GPCR	P28221	5HT1D_HUMAN	ANTAGONIST	Ki	6.60		IUPHAR
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	6.26		PDSP
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN		Ki	7.55		DRUG MATRIX
Alpha-1B adrenergic receptor	GPCR	P35368	ADA1B_HUMAN		Ki	8.10		PDSP
Calmodulin	Cytosolic other	P0DP23 P0DP24 P0DP25	CALM1_HUMAN CALM2_HUMAN CALM3_HUMAN		IC50	6.30		WOMBAT-PK
5-hydroxytryptamine receptor 5A	GPCR	P47898	5HT5A_HUMAN		Ki	5.65		PDSP
5-hydroxytryptamine receptor 1F	GPCR	P30939	5HT1F_HUMAN		Ki	5.30		PDSP
Glutamate receptor ionotropic, NMDA 2B	Ion channel	Q13224	NMDE2_HUMAN		Ki	7.89		CHEMBL
5-hydroxytryptamine receptor 1E	GPCR	P28566	5HT1E_HUMAN		Ki	5.30		PDSP
Potassium channel subfamily K member 2	Ion channel	O95069	KCNK2_HUMAN		IC50	5.26		CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III)	Ion channel	P35498 Q99250 Q9NY46	SCN1A_HUMAN SCN2A_HUMAN SCN3A_HUMAN		IC50	5.92		CHEMBL
Histone H1.0	Nuclear other	P07305	H10_HUMAN		Ki	6.11		CHEMBL
Transmembrane protein 97	Enzyme	Q5BJF2	TMM97_HUMAN		Ki	7.80		CHEMBL
Potassium voltage-gated channel subfamily H member 1	Ion channel	O95259	KCNH1_HUMAN	BLOCKER	IC50	6.20		IUPHAR
D(4) dopamine receptor	GPCR	P21917	DRD4_HUMAN	INVERSE AGONIST	Kd	9.42		SCIENTIFIC LITERATURE
Alpha-1B adrenergic receptor	GPCR		ADA1B_RAT		Ki	8.31		DRUG MATRIX
Membrane-associated progesterone receptor component 1	Membrane receptor		PGRC1_RAT		Ki	7.44		DRUG MATRIX
Pol polyprotein	Enzyme		Q72874_9HIV1		Ki	7		CHEMBL
Alpha-1A adrenergic receptor	GPCR		ADA1A_RAT		Kd	7.76		CHEMBL
Histamine H1 receptor	GPCR		HRH1_CAVPO		Ki	6.40		CHEMBL
Muscarinic acetylcholine receptor M2	GPCR		ACM2_RAT		Ki	6.62		CHEMBL
Muscarinic acetylcholine receptor M1	GPCR		ACM1_RAT		Ki	5.74		CHEMBL
D(2) dopamine receptor	GPCR		DRD2_RAT		Ki	9.70		CHEMBL
5-hydroxytryptamine receptor 1A	GPCR		5HT1A_RAT		Ki	6.40		CHEMBL
5-hydroxytryptamine receptor 2A	GPCR		5HT2A_RAT		Ki	7.35		CHEMBL
Sigma non-opioid intracellular receptor 1	Membrane receptor		SGMR1_RAT		Ki	9.05		CHEMBL
5-hydroxytryptamine receptor 7	GPCR		5HT7R_RAT		Ki	6.58		CHEMBL
5-hydroxytryptamine receptor 7	GPCR		5HT7R_MOUSE	ANTAGONIST	Ki	6.30		IUPHAR
D(1A) dopamine receptor	GPCR		DRD1_RAT		Ki	7.70		CHEMBL
D(2) dopamine receptor	GPCR		DRD2_BOVIN		Ki	9.52		CHEMBL
Alpha-1A adrenergic receptor	GPCR		ADA1A_BOVIN		IC50	7.70		CHEMBL
Histamine H1 receptor	GPCR		HRH1_RAT		Ki	6.42		CHEMBL
D(3) dopamine receptor	GPCR		DRD3_RAT		Ki	8.52		CHEMBL
Protease	Enzyme		Q4U254_9ENTO		Ki	7		CHEMBL
D(2) dopamine receptor	GPCR		DRD2_CHLAE		Ki	8.32		CHEMBL
5-hydroxytryptamine receptor 2A	GPCR		5HT2A_BOVIN		IC50	7.52		CHEMBL
C-8 sterol isomerase	Enzyme		ERG2_YEAST		Ki	9.30		CHEMBL
D(1A) dopamine receptor	GPCR		DRD1_PIG		Ki	7.03		CHEMBL
Sigma non-opioid intracellular receptor 1	Membrane other		SGMR1_CAVPO		Ki	9.08		CHEMBL
Transporter	Transporter		Q63380_RAT		Ki	5.26		CHEMBL
5-hydroxytryptamine receptor 2A	GPCR		5HT2A_PIG		Ki	7.52		CHEMBL
D(3) dopamine receptor	GPCR		DRD3_CHLAE		Ki	8.52		CHEMBL
Vesicular acetylcholine transporter	Transporter		VACHT_RAT		Ki	6.41		CHEMBL
AP-2 complex subunit sigma	Cytosolic other		AP2S1_RAT		Ki	7.62		CHEMBL
Muscarinic acetylcholine receptor	GPCR		ACM1_RAT ACM3_RAT ACM4_RAT ACM5_RAT ACM2_RAT		Ki	5.13		CHEMBL
Opioid receptor	GPCR		OPRD_RAT OPRM_RAT OPRK_RAT SGMR1_RAT		Ki	5.92		CHEMBL
Serotonin 1 (5-HT1) receptor	GPCR		5HT1A_RAT 5HT1B_RAT 5HT1D_RAT 5HT1F_RAT		IC50	4.70		CHEMBL
Adrenergic receptor alpha-2	GPCR		ADA2B_RAT ADA2C_RAT ADA2A_RAT		Ki	5.57		CHEMBL
Dopamine receptor	GPCR		DRD2_BOVIN DRD1_BOVIN		IC50	8.74		CHEMBL
Dopamine receptor	GPCR		DRD1_RAT DRD3_RAT DRD5_RAT DRD4_RAT DRD2_RAT		Ki	8.70		CHEMBL
Serotonin 2 (5-HT2) receptor	GPCR		5HT2C_RAT 5HT2A_RAT 5HT2B_RAT		Ki	8.38		CHEMBL
Adenylate cyclase	Enzyme		D4A3N4_RAT ADCY3_RAT ADCY2_RAT ADCY4_RAT ADCY8_RAT ADCY6_RAT ADCY5_RAT Q8CFM9_RAT		IC50	5.64		CHEMBL
Serotonin 2 (5-HT2) receptor	GPCR		5HT2C_MOUSE 5HT2A_MOUSE 5HT2B_MOUSE		Ki	7.58		CHEMBL
G protein-activated inward rectifier potassium channel 2	Ion channel		KCNJ6_MOUSE	GATING INHIBITOR	EC50	4.10		IUPHAR
Sigma intracellular receptor 2	Membrane receptor		SGMR2_RAT		Ki	7.36		CHEMBL
Zinc finger protein 664	Transcription factor		ZN664_CAVPO		Ki	8.18		CHEMBL

External reference:

ID	Source
4018123	VUID
N0000146461	NUI
D00136	KEGG_DRUG
53515-91-6	SECONDARY_CAS_RN
4018123	VANDF
4018125	VANDF
C0018546	UMLSCUI
CHEBI:5613	CHEBI
CHEMBL54	ChEMBL_ID
CHEMBL4297147	ChEMBL_ID
DB00502	DRUGBANK_ID
D006220	MESH_DESCRIPTOR_UI
3559	PUBCHEM_CID
86	IUPHAR_LIGAND_ID
918	INN_ID
J6292F8L3D	UNII
217483	RXNORM
2958	MMSL
4816	MMSL
4818	MMSL
583	MMSL
d00027	MMSL
001518	NDDF
001521	NDDF
10756001	SNOMEDCT_US
386837002	SNOMEDCT_US
412197008	SNOMEDCT_US
GMJ	PDB_CHEM_ID
J6292F8L3D	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0121-0581	SOLUTION	2 mg	ORAL	ANDA	16 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9319	INJECTION	5 mg	INTRAMUSCULAR	ANDA	16 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9501	INJECTION	5 mg	INTRAMUSCULAR	ANDA	16 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9502	INJECTION	5 mg	INTRAMUSCULAR	ANDA	16 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0214	TABLET	2 mg	ORAL	ANDA	16 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0257	TABLET	1 mg	ORAL	ANDA	16 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0327	TABLET	5 mg	ORAL	ANDA	16 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0334	TABLET	10 mg	ORAL	ANDA	16 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0335	TABLET	20 mg	ORAL	ANDA	16 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0351	TABLET	0.50 mg	ORAL	ANDA	16 sections
Haloperidol Lactate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9871	INJECTION, SOLUTION	5 mg	INTRAMUSCULAR	ANDA	13 sections
Haloperidol Lactate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9871	INJECTION, SOLUTION	5 mg	INTRAMUSCULAR	ANDA	13 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8626	TABLET	5 mg	ORAL	ANDA	13 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8627	TABLET	10 mg	ORAL	ANDA	13 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1510	TABLET	0.50 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1520	TABLET	1 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1530	TABLET	2 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1540	TABLET	5 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1550	TABLET	10 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1560	TABLET	20 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6661	TABLET	20 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6733	TABLET	10 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6782	TABLET	5 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7112	SOLUTION	2 mg	ORAL	ANDA	13 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7504	TABLET	2 mg	ORAL	ANDA	13 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	10135-752	TABLET	0.50 mg	ORAL	ANDA	12 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	10135-753	TABLET	1 mg	ORAL	ANDA	12 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	10135-754	TABLET	2 mg	ORAL	ANDA	12 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	10135-755	TABLET	5 mg	ORAL	ANDA	12 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	10135-756	TABLET	10 mg	ORAL	ANDA	12 sections