Stem definition | Drug id | CAS RN |
---|---|---|
antipsychotics, haloperidol derivatives | 1353 | 52-86-8 |
Dose | Unit | Route |
---|---|---|
8 | mg | O |
8 | mg | P |
3.30 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.04 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 1 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.57 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 60 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 17 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 7.80 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.08 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 35 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
April 12, 1967 | FDA | ORTHO MCNEIL |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuroleptic malignant syndrome | 1267.11 | 13.53 | 429 | 35012 | 10693 | 46639928 |
Extrapyramidal disorder | 1206.88 | 13.53 | 415 | 35026 | 10853 | 46639768 |
Intentional self-injury | 646.23 | 13.53 | 331 | 35110 | 23835 | 46626786 |
Akathisia | 392.06 | 13.53 | 165 | 35276 | 7549 | 46643072 |
Catatonia | 365.63 | 13.53 | 129 | 35312 | 3633 | 46646988 |
Dystonia | 347.28 | 13.53 | 170 | 35271 | 11087 | 46639534 |
Drug interaction | 333.26 | 13.53 | 571 | 34870 | 202523 | 46448098 |
Sopor | 330.31 | 13.53 | 199 | 35242 | 19629 | 46630992 |
Muscle rigidity | 314.98 | 13.53 | 153 | 35288 | 9808 | 46640813 |
Agitation | 312.81 | 13.53 | 290 | 35151 | 55125 | 46595496 |
Psychotic disorder | 306.19 | 13.53 | 199 | 35242 | 22422 | 46628199 |
Delirium | 264.38 | 13.53 | 222 | 35219 | 37006 | 46613615 |
Delusion | 258.27 | 13.53 | 139 | 35302 | 11049 | 46639572 |
Hallucination, auditory | 243.73 | 13.53 | 132 | 35309 | 10624 | 46639997 |
Schizophrenia | 242.34 | 13.53 | 122 | 35319 | 8446 | 46642175 |
Salivary hypersecretion | 234.34 | 13.53 | 109 | 35332 | 6336 | 46644285 |
Hyperprolactinaemia | 223.30 | 13.53 | 84 | 35357 | 2848 | 46647773 |
Parkinsonism | 218.44 | 13.53 | 111 | 35330 | 7837 | 46642784 |
Sedation | 217.21 | 13.53 | 162 | 35279 | 22748 | 46627873 |
Aggression | 209.34 | 13.53 | 158 | 35283 | 22586 | 46628035 |
Weight increased | 191.65 | 13.53 | 400 | 35041 | 164073 | 46486548 |
Suicide attempt | 187.70 | 13.53 | 220 | 35221 | 54816 | 46595805 |
Intentional overdose | 183.34 | 13.53 | 236 | 35205 | 64708 | 46585913 |
Tardive dyskinesia | 180.49 | 13.53 | 96 | 35345 | 7447 | 46643174 |
Restlessness | 174.56 | 13.53 | 149 | 35292 | 25375 | 46625246 |
Psychomotor hyperactivity | 174.44 | 13.53 | 102 | 35339 | 9511 | 46641110 |
Somnolence | 164.31 | 13.53 | 365 | 35076 | 156156 | 46494465 |
Electrocardiogram QT prolonged | 163.20 | 13.53 | 198 | 35243 | 51127 | 46599494 |
Hypothermia | 161.91 | 13.53 | 106 | 35335 | 12077 | 46638544 |
Rheumatoid arthritis | 156.31 | 13.53 | 6 | 35435 | 240209 | 46410412 |
Pain | 152.09 | 13.53 | 87 | 35354 | 476861 | 46173760 |
Arthralgia | 150.80 | 13.53 | 45 | 35396 | 364558 | 46286063 |
Coma | 140.12 | 13.53 | 196 | 35245 | 58153 | 46592468 |
Confusional state | 138.54 | 13.53 | 346 | 35095 | 159546 | 46491075 |
Headache | 132.58 | 13.53 | 102 | 35339 | 478250 | 46172371 |
Overdose | 129.24 | 13.53 | 257 | 35184 | 101722 | 46548899 |
Fatigue | 128.42 | 13.53 | 165 | 35276 | 608532 | 46042089 |
Bradykinesia | 119.60 | 13.53 | 59 | 35382 | 3907 | 46646714 |
Abnormal behaviour | 118.28 | 13.53 | 110 | 35331 | 20948 | 46629673 |
Blood creatine phosphokinase increased | 110.08 | 13.53 | 120 | 35321 | 27604 | 46623017 |
Dysarthria | 105.33 | 13.53 | 136 | 35305 | 37362 | 46613259 |
Tremor | 105.11 | 13.53 | 255 | 35186 | 115384 | 46535237 |
Torsade de pointes | 99.94 | 13.53 | 79 | 35362 | 12075 | 46638546 |
Dyskinesia | 99.16 | 13.53 | 116 | 35325 | 28809 | 46621812 |
Hypertonia | 98.90 | 13.53 | 54 | 35387 | 4412 | 46646209 |
Galactorrhoea | 95.58 | 13.53 | 50 | 35391 | 3747 | 46646874 |
Cogwheel rigidity | 93.20 | 13.53 | 37 | 35404 | 1453 | 46649168 |
Mutism | 90.90 | 13.53 | 35 | 35406 | 1265 | 46649356 |
Depressed level of consciousness | 88.70 | 13.53 | 142 | 35299 | 47427 | 46603194 |
Joint swelling | 88.43 | 13.53 | 11 | 35430 | 166062 | 46484559 |
Hallucination | 87.57 | 13.53 | 145 | 35296 | 49806 | 46600815 |
Paranoia | 87.39 | 13.53 | 69 | 35372 | 10528 | 46640093 |
Blood prolactin increased | 85.28 | 13.53 | 43 | 35398 | 2984 | 46647637 |
Bradyphrenia | 84.71 | 13.53 | 55 | 35386 | 6175 | 46644446 |
Pain in extremity | 83.93 | 13.53 | 46 | 35395 | 258634 | 46391987 |
Mania | 83.85 | 13.53 | 68 | 35373 | 10778 | 46639843 |
Embolism venous | 83.74 | 13.53 | 40 | 35401 | 2467 | 46648154 |
Sluggishness | 83.06 | 13.53 | 49 | 35392 | 4642 | 46645979 |
Tachycardia | 77.30 | 13.53 | 207 | 35234 | 99415 | 46551206 |
Stupor | 76.40 | 13.53 | 42 | 35399 | 3478 | 46647143 |
Rash | 75.58 | 13.53 | 96 | 35345 | 356416 | 46294205 |
Oculogyric crisis | 74.97 | 13.53 | 30 | 35411 | 1203 | 46649418 |
Alopecia | 72.77 | 13.53 | 17 | 35424 | 162397 | 46488224 |
Pruritus | 71.75 | 13.53 | 48 | 35393 | 242304 | 46408317 |
Toxicity to various agents | 71.42 | 13.53 | 334 | 35107 | 211432 | 46439189 |
Nausea | 67.74 | 13.53 | 281 | 35160 | 687173 | 45963448 |
Altered state of consciousness | 66.04 | 13.53 | 85 | 35356 | 23263 | 46627358 |
Treatment noncompliance | 65.63 | 13.53 | 96 | 35345 | 29635 | 46620986 |
Suicidal ideation | 65.31 | 13.53 | 137 | 35304 | 56245 | 46594376 |
Nasopharyngitis | 63.52 | 13.53 | 19 | 35422 | 153979 | 46496642 |
Sinusitis | 63.51 | 13.53 | 11 | 35430 | 129757 | 46520864 |
Drug abuse | 63.16 | 13.53 | 145 | 35296 | 63263 | 46587358 |
Pleurothotonus | 62.80 | 13.53 | 26 | 35415 | 1139 | 46649482 |
Pneumonia aspiration | 61.18 | 13.53 | 96 | 35345 | 31509 | 46619112 |
Drooling | 60.73 | 13.53 | 35 | 35406 | 3174 | 46647447 |
Schizoaffective disorder | 60.47 | 13.53 | 27 | 35414 | 1425 | 46649196 |
Encephalitis autoimmune | 60.30 | 13.53 | 25 | 35416 | 1099 | 46649522 |
Negativism | 60.28 | 13.53 | 19 | 35422 | 373 | 46650248 |
Injection site pain | 59.78 | 13.53 | 6 | 35435 | 107146 | 46543475 |
Drug level increased | 58.33 | 13.53 | 71 | 35370 | 18370 | 46632251 |
Infusion related reaction | 58.24 | 13.53 | 5 | 35436 | 101203 | 46549418 |
Abdominal discomfort | 58.22 | 13.53 | 21 | 35420 | 151144 | 46499477 |
Hypernatraemia | 57.83 | 13.53 | 44 | 35397 | 6357 | 46644264 |
Gestational diabetes | 57.37 | 13.53 | 46 | 35395 | 7173 | 46643448 |
Dyspnoea | 56.95 | 13.53 | 201 | 35240 | 515347 | 46135274 |
Persecutory delusion | 56.87 | 13.53 | 31 | 35410 | 2524 | 46648097 |
Ileus paralytic | 55.93 | 13.53 | 37 | 35404 | 4286 | 46646335 |
Stereotypy | 54.55 | 13.53 | 18 | 35423 | 411 | 46650210 |
Peripheral swelling | 54.36 | 13.53 | 26 | 35415 | 158045 | 46492576 |
Swelling | 53.88 | 13.53 | 14 | 35427 | 124497 | 46526124 |
Accidental exposure to product by child | 53.65 | 13.53 | 23 | 35418 | 1100 | 46649521 |
Diarrhoea | 53.62 | 13.53 | 231 | 35210 | 559371 | 46091250 |
Disorientation | 52.78 | 13.53 | 98 | 35343 | 36820 | 46613801 |
Arthropathy | 52.16 | 13.53 | 3 | 35438 | 84697 | 46565924 |
Cough | 51.90 | 13.53 | 59 | 35382 | 230190 | 46420431 |
Granulocytopenia | 51.54 | 13.53 | 38 | 35403 | 5235 | 46645386 |
Mental impairment | 51.32 | 13.53 | 55 | 35386 | 12401 | 46638220 |
Urinary retention | 50.22 | 13.53 | 79 | 35362 | 25982 | 46624639 |
Rhabdomyolysis | 48.72 | 13.53 | 102 | 35339 | 41807 | 46608814 |
Back pain | 48.23 | 13.53 | 53 | 35388 | 209986 | 46440635 |
Product dose omission issue | 46.40 | 13.53 | 36 | 35405 | 168484 | 46482137 |
Toxic epidermal necrolysis | 46.39 | 13.53 | 70 | 35371 | 22208 | 46628413 |
Oromandibular dystonia | 46.03 | 13.53 | 16 | 35425 | 430 | 46650191 |
Arthritis | 43.99 | 13.53 | 4 | 35437 | 77312 | 46573309 |
Miosis | 43.73 | 13.53 | 38 | 35403 | 6619 | 46644002 |
Cognitive disorder | 43.14 | 13.53 | 90 | 35351 | 36793 | 46613828 |
Antipsychotic drug level increased | 42.95 | 13.53 | 28 | 35413 | 3164 | 46647457 |
Psychomotor retardation | 42.63 | 13.53 | 28 | 35413 | 3205 | 46647416 |
Psoriasis | 42.32 | 13.53 | 5 | 35436 | 78599 | 46572022 |
Mental disorder | 41.86 | 13.53 | 67 | 35374 | 22358 | 46628263 |
Hyperammonaemic encephalopathy | 41.23 | 13.53 | 23 | 35418 | 1959 | 46648662 |
Serotonin syndrome | 40.68 | 13.53 | 69 | 35372 | 24151 | 46626470 |
Hyponatraemia | 40.27 | 13.53 | 168 | 35273 | 101164 | 46549457 |
Dysphagia | 39.63 | 13.53 | 139 | 35302 | 77173 | 46573448 |
Hyperthermia | 39.56 | 13.53 | 39 | 35402 | 7975 | 46642646 |
Injection site erythema | 39.41 | 13.53 | 5 | 35436 | 74422 | 46576199 |
Unresponsive to stimuli | 39.38 | 13.53 | 80 | 35361 | 32094 | 46618527 |
Lethargy | 39.32 | 13.53 | 106 | 35335 | 51065 | 46599556 |
Myalgia | 38.27 | 13.53 | 23 | 35418 | 123065 | 46527556 |
Bradycardia | 38.22 | 13.53 | 124 | 35317 | 66174 | 46584447 |
Psychotic symptom | 38.15 | 13.53 | 17 | 35424 | 893 | 46649728 |
Torticollis | 38.11 | 13.53 | 21 | 35420 | 1746 | 46648875 |
Dizziness | 37.97 | 13.53 | 132 | 35309 | 340282 | 46310339 |
Waxy flexibility | 37.67 | 13.53 | 10 | 35431 | 103 | 46650518 |
Drug intolerance | 37.30 | 13.53 | 34 | 35407 | 147015 | 46503606 |
Eosinophilic myocarditis | 37.03 | 13.53 | 13 | 35428 | 360 | 46650261 |
Influenza | 36.81 | 13.53 | 11 | 35430 | 89259 | 46561362 |
Urticaria | 36.69 | 13.53 | 22 | 35419 | 117870 | 46532751 |
Hyperreflexia | 36.57 | 13.53 | 31 | 35410 | 5223 | 46645398 |
Chest discomfort | 35.66 | 13.53 | 12 | 35429 | 90257 | 46560364 |
Hypersensitivity | 35.53 | 13.53 | 37 | 35404 | 150284 | 46500337 |
Systemic lupus erythematosus | 35.45 | 13.53 | 4 | 35437 | 65176 | 46585445 |
Akinesia | 35.03 | 13.53 | 20 | 35421 | 1781 | 46648840 |
Hallucinations, mixed | 33.76 | 13.53 | 26 | 35415 | 3823 | 46646798 |
Paraesthesia | 33.72 | 13.53 | 24 | 35417 | 117413 | 46533208 |
Mental status changes | 33.48 | 13.53 | 83 | 35358 | 38005 | 46612616 |
White blood cell count increased | 33.37 | 13.53 | 91 | 35350 | 44128 | 46606493 |
Illogical thinking | 33.01 | 13.53 | 8 | 35433 | 55 | 46650566 |
Abdominal pain upper | 32.97 | 13.53 | 37 | 35404 | 145268 | 46505353 |
Somatic symptom disorder of pregnancy | 32.81 | 13.53 | 9 | 35432 | 106 | 46650515 |
Hallucination, visual | 32.81 | 13.53 | 53 | 35388 | 17820 | 46632801 |
Echolalia | 32.80 | 13.53 | 10 | 35431 | 175 | 46650446 |
Herpes zoster | 32.65 | 13.53 | 6 | 35435 | 67866 | 46582755 |
Metabolic syndrome | 32.58 | 13.53 | 17 | 35424 | 1267 | 46649354 |
Disturbance in attention | 32.33 | 13.53 | 73 | 35368 | 31487 | 46619134 |
Chest pain | 31.84 | 13.53 | 53 | 35388 | 176271 | 46474350 |
Behaviour disorder | 30.88 | 13.53 | 19 | 35422 | 1942 | 46648679 |
Musculoskeletal pain | 30.10 | 13.53 | 8 | 35433 | 70120 | 46580501 |
Feeling guilty | 29.99 | 13.53 | 12 | 35429 | 481 | 46650140 |
Myocarditis | 29.84 | 13.53 | 33 | 35408 | 7706 | 46642915 |
Sexually inappropriate behaviour | 29.18 | 13.53 | 8 | 35433 | 94 | 46650527 |
Social avoidant behaviour | 28.97 | 13.53 | 21 | 35420 | 2818 | 46647803 |
Neutrophil count increased | 28.56 | 13.53 | 44 | 35397 | 14209 | 46636412 |
Flushing | 28.45 | 13.53 | 7 | 35434 | 64607 | 46586014 |
Nephrogenic diabetes insipidus | 28.03 | 13.53 | 13 | 35428 | 750 | 46649871 |
Cardiac arrest | 27.80 | 13.53 | 139 | 35302 | 90260 | 46560361 |
Reduced facial expression | 27.70 | 13.53 | 15 | 35426 | 1205 | 46649416 |
Contraindicated product administered | 27.69 | 13.53 | 13 | 35428 | 79934 | 46570687 |
Asthenia | 27.52 | 13.53 | 132 | 35309 | 310943 | 46339678 |
Sudden death | 27.50 | 13.53 | 35 | 35406 | 9469 | 46641152 |
Bronchitis | 27.47 | 13.53 | 24 | 35417 | 105955 | 46544666 |
Sinus bradycardia | 26.85 | 13.53 | 42 | 35399 | 13740 | 46636881 |
Treatment failure | 26.75 | 13.53 | 19 | 35422 | 93068 | 46557553 |
Electrocardiogram PR prolongation | 26.63 | 13.53 | 12 | 35429 | 647 | 46649974 |
Flight of ideas | 26.60 | 13.53 | 10 | 35431 | 338 | 46650283 |
Psychomotor skills impaired | 26.57 | 13.53 | 18 | 35423 | 2168 | 46648453 |
Respiratory failure | 26.53 | 13.53 | 142 | 35299 | 94674 | 46555947 |
Refusal of treatment by patient | 26.07 | 13.53 | 26 | 35415 | 5389 | 46645232 |
Stress | 26.03 | 13.53 | 4 | 35437 | 51547 | 46599074 |
Pulmonary embolism | 26.02 | 13.53 | 156 | 35285 | 108429 | 46542192 |
Speech disorder | 25.87 | 13.53 | 73 | 35368 | 36094 | 46614527 |
Electroencephalogram abnormal | 25.82 | 13.53 | 22 | 35419 | 3732 | 46646889 |
Influenza like illness | 25.81 | 13.53 | 6 | 35435 | 57564 | 46593057 |
Contusion | 24.95 | 13.53 | 18 | 35423 | 87469 | 46563152 |
Generalised tonic-clonic seizure | 24.79 | 13.53 | 60 | 35381 | 27062 | 46623559 |
Inappropriate antidiuretic hormone secretion | 24.77 | 13.53 | 41 | 35400 | 14061 | 46636560 |
Asthma | 24.62 | 13.53 | 20 | 35421 | 91522 | 46559099 |
Dementia | 24.36 | 13.53 | 42 | 35399 | 14888 | 46635733 |
Blunted affect | 24.11 | 13.53 | 8 | 35433 | 186 | 46650435 |
Nasal congestion | 23.69 | 13.53 | 4 | 35437 | 48109 | 46602512 |
Muscle enzyme increased | 23.60 | 13.53 | 7 | 35434 | 111 | 46650510 |
Thinking abnormal | 23.57 | 13.53 | 33 | 35408 | 9781 | 46640840 |
Haemoglobin urine | 23.48 | 13.53 | 7 | 35434 | 113 | 46650508 |
Burning sensation | 23.47 | 13.53 | 3 | 35438 | 44408 | 46606213 |
Disorganised speech | 23.45 | 13.53 | 12 | 35429 | 859 | 46649762 |
Differential white blood cell count abnormal | 23.40 | 13.53 | 11 | 35430 | 654 | 46649967 |
Weight decreased | 23.30 | 13.53 | 82 | 35359 | 210767 | 46439854 |
Opisthotonus | 23.30 | 13.53 | 9 | 35432 | 328 | 46650293 |
Acute psychosis | 23.26 | 13.53 | 16 | 35425 | 1976 | 46648645 |
Osteoarthritis | 23.21 | 13.53 | 9 | 35432 | 62016 | 46588605 |
Exposure during pregnancy | 23.14 | 13.53 | 151 | 35290 | 108061 | 46542560 |
Parkinsonian gait | 23.08 | 13.53 | 10 | 35431 | 491 | 46650130 |
Dyspnoea exertional | 23.03 | 13.53 | 5 | 35436 | 50284 | 46600337 |
Hypersexuality | 22.98 | 13.53 | 10 | 35431 | 496 | 46650125 |
Electroconvulsive therapy | 22.85 | 13.53 | 6 | 35435 | 59 | 46650562 |
Malaise | 22.58 | 13.53 | 153 | 35288 | 331079 | 46319542 |
Screaming | 22.56 | 13.53 | 19 | 35422 | 3172 | 46647449 |
Staring | 22.53 | 13.53 | 14 | 35427 | 1456 | 46649165 |
Bone marrow eosinophilic leukocyte count increased | 22.32 | 13.53 | 5 | 35436 | 23 | 46650598 |
Irritability | 22.26 | 13.53 | 60 | 35381 | 28886 | 46621735 |
Drug ineffective | 22.17 | 13.53 | 372 | 35069 | 677466 | 45973155 |
Impulsive behaviour | 22.14 | 13.53 | 14 | 35427 | 1501 | 46649120 |
Polydipsia | 22.11 | 13.53 | 19 | 35422 | 3260 | 46647361 |
False positive investigation result | 22.08 | 13.53 | 10 | 35431 | 546 | 46650075 |
General physical health deterioration | 22.05 | 13.53 | 157 | 35284 | 115612 | 46535009 |
Diabetic coma | 21.76 | 13.53 | 11 | 35430 | 767 | 46649854 |
Malignant catatonia | 21.66 | 13.53 | 5 | 35436 | 27 | 46650594 |
Leukocytosis | 21.64 | 13.53 | 52 | 35389 | 23346 | 46627275 |
Incorrect route of product administration | 21.56 | 13.53 | 42 | 35399 | 16341 | 46634280 |
Amenorrhoea | 21.50 | 13.53 | 30 | 35411 | 8865 | 46641756 |
Duodenal stenosis | 21.48 | 13.53 | 10 | 35431 | 582 | 46650039 |
Allergic hepatitis | 21.36 | 13.53 | 5 | 35436 | 29 | 46650592 |
Hypoaesthesia | 21.20 | 13.53 | 36 | 35405 | 118833 | 46531788 |
Rash pruritic | 21.07 | 13.53 | 4 | 35437 | 44211 | 46606410 |
Tongue biting | 20.93 | 13.53 | 13 | 35428 | 1351 | 46649270 |
Neuropathy peripheral | 20.76 | 13.53 | 23 | 35418 | 90870 | 46559751 |
Antipsychotic drug level below therapeutic | 20.75 | 13.53 | 8 | 35433 | 290 | 46650331 |
Delusion of reference | 20.60 | 13.53 | 6 | 35435 | 89 | 46650532 |
Femoral neck fracture | 20.59 | 13.53 | 28 | 35413 | 8075 | 46642546 |
Psychiatric decompensation | 20.59 | 13.53 | 12 | 35429 | 1111 | 46649510 |
Protrusion tongue | 19.78 | 13.53 | 8 | 35433 | 330 | 46650291 |
Upper respiratory tract infection | 19.57 | 13.53 | 12 | 35429 | 63544 | 46587077 |
Injection site reaction | 19.53 | 13.53 | 6 | 35435 | 47843 | 46602778 |
Pain in jaw | 19.32 | 13.53 | 3 | 35438 | 38369 | 46612252 |
Hyperthermia malignant | 19.24 | 13.53 | 10 | 35431 | 739 | 46649882 |
Agranulocytosis | 19.13 | 13.53 | 48 | 35393 | 22137 | 46628484 |
Pulmonary vasculitis | 18.97 | 13.53 | 5 | 35436 | 50 | 46650571 |
Leukopenia | 18.87 | 13.53 | 102 | 35339 | 68241 | 46582380 |
Nuchal rigidity | 18.66 | 13.53 | 9 | 35432 | 567 | 46650054 |
Hot flush | 18.61 | 13.53 | 5 | 35436 | 43512 | 46607109 |
Pressure of speech | 18.60 | 13.53 | 9 | 35432 | 571 | 46650050 |
Hypoxic-ischaemic encephalopathy | 18.59 | 13.53 | 19 | 35422 | 4054 | 46646567 |
Clonus | 18.57 | 13.53 | 19 | 35422 | 4061 | 46646560 |
Lipids decreased | 18.52 | 13.53 | 4 | 35437 | 15 | 46650606 |
Apathy | 18.30 | 13.53 | 25 | 35416 | 7243 | 46643378 |
Communication disorder | 18.27 | 13.53 | 15 | 35426 | 2418 | 46648203 |
Erythema | 18.26 | 13.53 | 52 | 35389 | 142768 | 46507853 |
Wound | 18.15 | 13.53 | 5 | 35436 | 42797 | 46607824 |
Venous thrombosis limb | 18.12 | 13.53 | 16 | 35425 | 2847 | 46647774 |
Fibromyalgia | 18.02 | 13.53 | 3 | 35438 | 36460 | 46614161 |
Red blood cells urine | 17.81 | 13.53 | 8 | 35433 | 428 | 46650193 |
Self-medication | 17.71 | 13.53 | 14 | 35427 | 2138 | 46648483 |
Multiple sclerosis relapse | 17.71 | 13.53 | 5 | 35436 | 42120 | 46608501 |
Electrocardiogram abnormal | 17.47 | 13.53 | 24 | 35417 | 6988 | 46643633 |
Dyspepsia | 17.15 | 13.53 | 16 | 35425 | 68456 | 46582165 |
Systemic infection | 17.11 | 13.53 | 9 | 35432 | 682 | 46649939 |
Coma scale abnormal | 17.02 | 13.53 | 20 | 35421 | 4986 | 46645635 |
Dry skin | 17.00 | 13.53 | 5 | 35436 | 41011 | 46609610 |
Diabetes mellitus | 16.83 | 13.53 | 79 | 35362 | 49986 | 46600635 |
Respiratory depression | 16.83 | 13.53 | 31 | 35410 | 11569 | 46639052 |
Anticonvulsant drug level above therapeutic | 16.78 | 13.53 | 8 | 35433 | 491 | 46650130 |
Brief psychotic disorder with marked stressors | 16.76 | 13.53 | 5 | 35436 | 81 | 46650540 |
Fluid retention | 16.62 | 13.53 | 9 | 35432 | 51037 | 46599584 |
Wheezing | 16.55 | 13.53 | 10 | 35431 | 53376 | 46597245 |
Prescribed overdose | 16.53 | 13.53 | 29 | 35412 | 10420 | 46640201 |
Grandiosity | 16.39 | 13.53 | 6 | 35435 | 188 | 46650433 |
Poor personal hygiene | 16.36 | 13.53 | 7 | 35434 | 333 | 46650288 |
Impaired healing | 16.13 | 13.53 | 4 | 35437 | 36739 | 46613882 |
Decreased eye contact | 16.11 | 13.53 | 5 | 35436 | 93 | 46650528 |
Euphoric mood | 16.10 | 13.53 | 18 | 35423 | 4254 | 46646367 |
Cardiomyopathy alcoholic | 16.08 | 13.53 | 4 | 35437 | 31 | 46650590 |
Blood glucose | 16.08 | 13.53 | 4 | 35437 | 31 | 46650590 |
Illusion | 16.04 | 13.53 | 10 | 35431 | 1046 | 46649575 |
Anaemia | 16.02 | 13.53 | 121 | 35320 | 255658 | 46394963 |
Somatic hallucination | 16.01 | 13.53 | 3 | 35438 | 4 | 46650617 |
Seizure | 15.95 | 13.53 | 153 | 35288 | 122901 | 46527720 |
Cellulitis | 15.82 | 13.53 | 18 | 35423 | 70270 | 46580351 |
Circadian rhythm sleep disorder | 15.68 | 13.53 | 6 | 35435 | 213 | 46650408 |
Granulomatous liver disease | 15.60 | 13.53 | 9 | 35432 | 817 | 46649804 |
Accidental exposure to product | 15.52 | 13.53 | 43 | 35398 | 21038 | 46629583 |
Ureteric obstruction | 15.24 | 13.53 | 12 | 35429 | 1822 | 46648799 |
Retinitis pigmentosa | 15.16 | 13.53 | 5 | 35436 | 114 | 46650507 |
Apallic syndrome | 15.10 | 13.53 | 8 | 35433 | 615 | 46650006 |
Tonic clonic movements | 15.09 | 13.53 | 10 | 35431 | 1162 | 46649459 |
Palpitations | 15.08 | 13.53 | 31 | 35410 | 95228 | 46555393 |
Hypotonia neonatal | 15.08 | 13.53 | 9 | 35432 | 871 | 46649750 |
Dissociation | 15.00 | 13.53 | 12 | 35429 | 1865 | 46648756 |
Hypokinesia | 14.87 | 13.53 | 29 | 35412 | 11293 | 46639328 |
Epileptic encephalopathy | 14.75 | 13.53 | 6 | 35435 | 251 | 46650370 |
Gastrooesophageal reflux disease | 14.69 | 13.53 | 21 | 35420 | 74323 | 46576298 |
Electrolyte imbalance | 14.57 | 13.53 | 37 | 35404 | 17189 | 46633432 |
Oedema peripheral | 14.55 | 13.53 | 67 | 35374 | 159639 | 46490982 |
Cardiac failure congestive | 14.40 | 13.53 | 30 | 35411 | 91720 | 46558901 |
Neonatal intestinal obstruction | 14.40 | 13.53 | 3 | 35438 | 9 | 46650612 |
Grimacing | 14.38 | 13.53 | 7 | 35434 | 450 | 46650171 |
Encephalopathy | 14.37 | 13.53 | 57 | 35384 | 33532 | 46617089 |
Carnitine deficiency | 14.36 | 13.53 | 5 | 35436 | 135 | 46650486 |
Antidepressant drug level increased | 14.28 | 13.53 | 6 | 35435 | 273 | 46650348 |
Autonomic nervous system imbalance | 14.25 | 13.53 | 13 | 35428 | 2413 | 46648208 |
Eosinophil count abnormal | 14.18 | 13.53 | 7 | 35434 | 464 | 46650157 |
Blood pressure increased | 14.15 | 13.53 | 49 | 35392 | 126617 | 46524004 |
Mental disorder due to a general medical condition | 14.12 | 13.53 | 5 | 35436 | 142 | 46650479 |
Discomfort | 14.11 | 13.53 | 9 | 35432 | 46661 | 46603960 |
Brain oedema | 14.06 | 13.53 | 30 | 35411 | 12448 | 46638173 |
Hypomania | 14.04 | 13.53 | 17 | 35424 | 4371 | 46646250 |
Echopraxia | 13.94 | 13.53 | 3 | 35438 | 11 | 46650610 |
Lactate pyruvate ratio increased | 13.88 | 13.53 | 4 | 35437 | 57 | 46650564 |
Mydriasis | 13.82 | 13.53 | 27 | 35414 | 10526 | 46640095 |
Optic nerve disorder | 13.77 | 13.53 | 8 | 35433 | 736 | 46649885 |
Aspiration of gastric residual | 13.73 | 13.53 | 3 | 35438 | 12 | 46650609 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuroleptic malignant syndrome | 1637.30 | 12.89 | 684 | 43365 | 15611 | 29892818 |
Extrapyramidal disorder | 1488.53 | 12.89 | 568 | 43481 | 10125 | 29898304 |
Dystonia | 609.95 | 12.89 | 294 | 43755 | 9433 | 29898996 |
Intentional self-injury | 510.37 | 12.89 | 291 | 43758 | 13241 | 29895188 |
Agitation | 486.11 | 12.89 | 492 | 43557 | 53581 | 29854848 |
Akathisia | 396.09 | 12.89 | 187 | 43862 | 5717 | 29902712 |
Muscle rigidity | 395.85 | 12.89 | 224 | 43825 | 10037 | 29898392 |
Psychotic disorder | 371.61 | 12.89 | 284 | 43765 | 21231 | 29887198 |
Delirium | 336.53 | 12.89 | 354 | 43695 | 40277 | 29868152 |
Sedation | 327.26 | 12.89 | 236 | 43813 | 16137 | 29892292 |
Aggression | 308.19 | 12.89 | 323 | 43726 | 36584 | 29871845 |
Weight increased | 304.70 | 12.89 | 457 | 43592 | 74456 | 29833973 |
Parkinsonism | 300.25 | 12.89 | 166 | 43883 | 7103 | 29901326 |
Catatonia | 294.61 | 12.89 | 139 | 43910 | 4241 | 29904188 |
Tardive dyskinesia | 293.34 | 12.89 | 145 | 43904 | 4912 | 29903517 |
Schizophrenia | 271.58 | 12.89 | 168 | 43881 | 8880 | 29899549 |
Salivary hypersecretion | 238.60 | 12.89 | 145 | 43904 | 7421 | 29901008 |
Sopor | 230.10 | 12.89 | 163 | 43886 | 10828 | 29897601 |
Blood creatine phosphokinase increased | 223.25 | 12.89 | 298 | 43751 | 43550 | 29864879 |
Hyperprolactinaemia | 215.57 | 12.89 | 77 | 43972 | 1123 | 29907306 |
Tachycardia | 193.32 | 12.89 | 370 | 43679 | 73369 | 29835060 |
Delusion | 184.70 | 12.89 | 148 | 43901 | 11841 | 29896588 |
Drug interaction | 184.03 | 12.89 | 677 | 43372 | 198891 | 29709538 |
Electrocardiogram QT prolonged | 181.52 | 12.89 | 243 | 43806 | 35592 | 29872837 |
Suicide attempt | 180.04 | 12.89 | 245 | 43804 | 36452 | 29871977 |
Hallucination, auditory | 179.50 | 12.89 | 134 | 43915 | 9655 | 29898774 |
Dyskinesia | 171.35 | 12.89 | 185 | 43864 | 21649 | 29886780 |
Somnolence | 171.26 | 12.89 | 414 | 43635 | 96349 | 29812080 |
Intentional overdose | 143.28 | 12.89 | 235 | 43814 | 41246 | 29867183 |
Hypertonia | 140.71 | 12.89 | 85 | 43964 | 4300 | 29904129 |
Diarrhoea | 128.69 | 12.89 | 183 | 43866 | 333920 | 29574509 |
Restlessness | 128.03 | 12.89 | 162 | 43887 | 22437 | 29885992 |
Tremor | 123.25 | 12.89 | 313 | 43736 | 75050 | 29833379 |
Fatigue | 118.23 | 12.89 | 181 | 43868 | 320492 | 29587937 |
Dyspnoea | 114.57 | 12.89 | 197 | 43852 | 333098 | 29575331 |
Embolism venous | 111.99 | 12.89 | 49 | 44000 | 1248 | 29907181 |
Rhabdomyolysis | 109.11 | 12.89 | 269 | 43780 | 63311 | 29845118 |
Arthralgia | 105.82 | 12.89 | 34 | 44015 | 135757 | 29772672 |
Rash | 105.67 | 12.89 | 77 | 43972 | 191812 | 29716617 |
Granulocytopenia | 104.80 | 12.89 | 81 | 43968 | 6145 | 29902284 |
Emotional poverty | 104.46 | 12.89 | 33 | 44016 | 321 | 29908108 |
Oculogyric crisis | 102.91 | 12.89 | 47 | 44002 | 1328 | 29907101 |
Psychomotor hyperactivity | 100.80 | 12.89 | 89 | 43960 | 8135 | 29900294 |
Coma | 98.60 | 12.89 | 197 | 43852 | 40252 | 29868177 |
Oropharyngeal spasm | 94.71 | 12.89 | 26 | 44023 | 146 | 29908283 |
Nausea | 94.41 | 12.89 | 184 | 43865 | 296773 | 29611656 |
Serotonin syndrome | 90.04 | 12.89 | 121 | 43928 | 17770 | 29890659 |
Hypothermia | 89.31 | 12.89 | 89 | 43960 | 9478 | 29898951 |
Antipsychotic drug level below therapeutic | 87.54 | 12.89 | 42 | 44007 | 1330 | 29907099 |
Toxicity to various agents | 85.13 | 12.89 | 497 | 43552 | 176686 | 29731743 |
Headache | 84.70 | 12.89 | 86 | 43963 | 182220 | 29726209 |
Dizziness | 82.79 | 12.89 | 99 | 43950 | 194810 | 29713619 |
Cogwheel rigidity | 82.41 | 12.89 | 38 | 44011 | 1098 | 29907331 |
Disinhibition | 81.63 | 12.89 | 45 | 44004 | 1912 | 29906517 |
Altered state of consciousness | 81.44 | 12.89 | 122 | 43927 | 19797 | 29888632 |
Mutism | 80.52 | 12.89 | 33 | 44016 | 711 | 29907718 |
Dysphagia | 78.99 | 12.89 | 222 | 43827 | 56476 | 29851953 |
Cognitive disorder | 78.78 | 12.89 | 132 | 43917 | 23558 | 29884871 |
Hyperthermia | 78.19 | 12.89 | 85 | 43964 | 10014 | 29898415 |
Abnormal behaviour | 75.06 | 12.89 | 135 | 43914 | 25488 | 29882941 |
Obsessive-compulsive disorder | 74.37 | 12.89 | 56 | 43993 | 4085 | 29904344 |
Asthenia | 73.85 | 12.89 | 133 | 43916 | 221157 | 29687272 |
Anaemia | 73.05 | 12.89 | 121 | 43928 | 207871 | 29700558 |
Torsade de pointes | 72.92 | 12.89 | 70 | 43979 | 7120 | 29901309 |
Pneumonia aspiration | 72.49 | 12.89 | 167 | 43882 | 37613 | 29870816 |
Myocardial infarction | 69.61 | 12.89 | 50 | 43999 | 125575 | 29782854 |
Cardiac failure congestive | 69.60 | 12.89 | 19 | 44030 | 84388 | 29824041 |
Pain in extremity | 69.15 | 12.89 | 38 | 44011 | 110183 | 29798246 |
Sluggishness | 68.98 | 12.89 | 48 | 44001 | 3095 | 29905334 |
Psychotic symptom | 68.66 | 12.89 | 34 | 44015 | 1155 | 29907274 |
Depressed level of consciousness | 67.95 | 12.89 | 164 | 43885 | 38058 | 29870371 |
Dysarthria | 67.79 | 12.89 | 143 | 43906 | 30347 | 29878082 |
Treatment noncompliance | 66.38 | 12.89 | 127 | 43922 | 25126 | 29883303 |
Torticollis | 65.84 | 12.89 | 32 | 44017 | 1043 | 29907386 |
Pain | 64.81 | 12.89 | 96 | 43953 | 172545 | 29735884 |
Incorrect route of product administration | 63.88 | 12.89 | 81 | 43968 | 11234 | 29897195 |
Drooling | 63.87 | 12.89 | 45 | 44004 | 2960 | 29905469 |
Cough | 63.32 | 12.89 | 55 | 43994 | 125587 | 29782842 |
Opisthotonus | 62.03 | 12.89 | 23 | 44026 | 375 | 29908054 |
Paranoia | 60.82 | 12.89 | 75 | 43974 | 10113 | 29898316 |
Mania | 60.56 | 12.89 | 71 | 43978 | 9083 | 29899346 |
Persecutory delusion | 59.82 | 12.89 | 38 | 44011 | 2102 | 29906327 |
Intestinal pseudo-obstruction | 58.07 | 12.89 | 30 | 44019 | 1116 | 29907313 |
Protrusion tongue | 57.32 | 12.89 | 19 | 44030 | 218 | 29908211 |
Nasopharyngitis | 57.24 | 12.89 | 9 | 44040 | 58840 | 29849589 |
Disorientation | 57.12 | 12.89 | 136 | 43913 | 31282 | 29877147 |
Spasmodic dysphonia | 56.77 | 12.89 | 15 | 44034 | 71 | 29908358 |
Confusional state | 56.32 | 12.89 | 365 | 43684 | 134469 | 29773960 |
Myocarditis | 55.46 | 12.89 | 71 | 43978 | 9940 | 29898489 |
Accidental exposure to product by child | 54.58 | 12.89 | 32 | 44017 | 1531 | 29906898 |
Stupor | 53.17 | 12.89 | 40 | 44009 | 2913 | 29905516 |
Antipsychotic drug level increased | 50.70 | 12.89 | 40 | 44009 | 3126 | 29905303 |
Hallucination | 50.57 | 12.89 | 173 | 43876 | 48886 | 29859543 |
White blood cell count increased | 50.08 | 12.89 | 150 | 43899 | 39523 | 29868906 |
Bradykinesia | 49.99 | 12.89 | 40 | 44009 | 3190 | 29905239 |
Death | 49.26 | 12.89 | 316 | 43733 | 356967 | 29551462 |
Back pain | 49.19 | 12.89 | 47 | 44002 | 102549 | 29805880 |
Psychomotor retardation | 49.11 | 12.89 | 35 | 44014 | 2344 | 29906085 |
Pneumonia | 49.03 | 12.89 | 290 | 43759 | 334016 | 29574413 |
Febrile neutropenia | 48.72 | 12.89 | 51 | 43998 | 106642 | 29801787 |
Speech disorder | 47.72 | 12.89 | 109 | 43940 | 24403 | 29884026 |
Psoriasis | 47.55 | 12.89 | 4 | 44045 | 42502 | 29865927 |
Therapeutic product effect variable | 47.35 | 12.89 | 28 | 44021 | 1361 | 29907068 |
Neuropathy peripheral | 46.09 | 12.89 | 23 | 44026 | 70452 | 29837977 |
Euphoric mood | 45.85 | 12.89 | 43 | 44006 | 4247 | 29904182 |
Hyperreflexia | 45.74 | 12.89 | 36 | 44013 | 2803 | 29905626 |
Visceral congestion | 45.18 | 12.89 | 20 | 44029 | 524 | 29907905 |
Product dose omission issue | 45.07 | 12.89 | 41 | 44008 | 91590 | 29816839 |
Pruritus | 45.03 | 12.89 | 65 | 43984 | 118139 | 29790290 |
Infusion related reaction | 44.88 | 12.89 | 4 | 44045 | 40560 | 29867869 |
Increased appetite | 44.75 | 12.89 | 48 | 44001 | 5569 | 29902860 |
Priapism | 44.03 | 12.89 | 44 | 44005 | 4699 | 29903730 |
Myoclonus | 44.01 | 12.89 | 74 | 43975 | 13238 | 29895191 |
Schizoaffective disorder | 43.18 | 12.89 | 24 | 44025 | 1036 | 29907393 |
Bradyphrenia | 42.94 | 12.89 | 40 | 44009 | 3917 | 29904512 |
Oromandibular dystonia | 41.55 | 12.89 | 18 | 44031 | 447 | 29907982 |
Disturbance in attention | 41.53 | 12.89 | 97 | 43952 | 22032 | 29886397 |
Cerebrovascular accident | 41.47 | 12.89 | 37 | 44012 | 83440 | 29824989 |
Peripheral swelling | 41.36 | 12.89 | 19 | 44030 | 61055 | 29847374 |
Social avoidant behaviour | 41.24 | 12.89 | 34 | 44015 | 2829 | 29905600 |
Interstitial lung disease | 40.34 | 12.89 | 19 | 44030 | 60178 | 29848251 |
Water intoxication | 40.23 | 12.89 | 18 | 44031 | 484 | 29907945 |
Autonomic nervous system imbalance | 39.66 | 12.89 | 31 | 44018 | 2390 | 29906039 |
Eye movement disorder | 39.05 | 12.89 | 38 | 44011 | 3930 | 29904499 |
Overdose | 38.71 | 12.89 | 234 | 43815 | 84103 | 29824326 |
Abdominal pain upper | 38.57 | 12.89 | 22 | 44027 | 62529 | 29845900 |
Product packaging issue | 37.76 | 12.89 | 17 | 44032 | 464 | 29907965 |
Ileus paralytic | 37.68 | 12.89 | 44 | 44005 | 5604 | 29902825 |
Medication error | 37.27 | 12.89 | 90 | 43959 | 20882 | 29887547 |
Influenza | 37.23 | 12.89 | 9 | 44040 | 43389 | 29865040 |
Mental impairment | 36.74 | 12.89 | 56 | 43993 | 9221 | 29899208 |
Refusal of treatment by patient | 36.47 | 12.89 | 41 | 44008 | 5012 | 29903417 |
Self-injurious ideation | 36.31 | 12.89 | 25 | 44024 | 1584 | 29906845 |
Pyramidal tract syndrome | 36.17 | 12.89 | 13 | 44036 | 193 | 29908236 |
Chest pain | 35.42 | 12.89 | 75 | 43974 | 117552 | 29790877 |
Waxy flexibility | 35.10 | 12.89 | 11 | 44038 | 104 | 29908325 |
Atrial fibrillation | 35.07 | 12.89 | 66 | 43983 | 108058 | 29800371 |
Mental disorder | 34.55 | 12.89 | 67 | 43982 | 13382 | 29895047 |
Coronary artery disease | 34.39 | 12.89 | 15 | 44034 | 49697 | 29858732 |
Joint swelling | 34.37 | 12.89 | 13 | 44036 | 46933 | 29861496 |
Psychosexual disorder | 33.95 | 12.89 | 10 | 44039 | 75 | 29908354 |
Trismus | 33.89 | 12.89 | 28 | 44021 | 2337 | 29906092 |
Body temperature increased | 33.63 | 12.89 | 70 | 43979 | 14710 | 29893719 |
Psychiatric decompensation | 33.43 | 12.89 | 22 | 44027 | 1293 | 29907136 |
Tic | 33.24 | 12.89 | 26 | 44023 | 2006 | 29906423 |
Urticaria | 32.54 | 12.89 | 20 | 44029 | 54586 | 29853843 |
Oral discharge | 32.44 | 12.89 | 11 | 44038 | 136 | 29908293 |
Dyslipidaemia | 32.33 | 12.89 | 41 | 44008 | 5686 | 29902743 |
Oedema peripheral | 32.26 | 12.89 | 67 | 43982 | 105765 | 29802664 |
Choking | 32.11 | 12.89 | 38 | 44011 | 4908 | 29903521 |
Erythema | 32.11 | 12.89 | 40 | 44009 | 77411 | 29831018 |
Colitis ischaemic | 31.99 | 12.89 | 41 | 44008 | 5745 | 29902684 |
Tachypnoea | 31.92 | 12.89 | 69 | 43980 | 14883 | 29893546 |
Anticholinergic syndrome | 31.78 | 12.89 | 18 | 44031 | 806 | 29907623 |
Huntington's disease | 31.60 | 12.89 | 9 | 44040 | 59 | 29908370 |
Rapid eye movement sleep behaviour disorder | 31.05 | 12.89 | 10 | 44039 | 104 | 29908325 |
Chest discomfort | 31.02 | 12.89 | 14 | 44035 | 45466 | 29862963 |
Blood prolactin abnormal | 30.80 | 12.89 | 17 | 44032 | 724 | 29907705 |
Malignant catatonia | 30.39 | 12.89 | 10 | 44039 | 112 | 29908317 |
Compulsive sexual behaviour | 30.20 | 12.89 | 12 | 44037 | 238 | 29908191 |
Asthma | 30.07 | 12.89 | 8 | 44041 | 36166 | 29872263 |
Urinary retention | 29.57 | 12.89 | 111 | 43938 | 32806 | 29875623 |
Blood prolactin increased | 29.54 | 12.89 | 21 | 44028 | 1401 | 29907028 |
Epistaxis | 29.42 | 12.89 | 21 | 44028 | 52960 | 29855469 |
Dyspnoea exertional | 29.14 | 12.89 | 8 | 44041 | 35422 | 29873007 |
Epilepsy | 29.07 | 12.89 | 80 | 43969 | 20089 | 29888340 |
Delusion of grandeur | 28.87 | 12.89 | 13 | 44036 | 355 | 29908074 |
Sinusitis | 28.43 | 12.89 | 7 | 44042 | 33338 | 29875091 |
Patient restraint | 28.35 | 12.89 | 9 | 44040 | 89 | 29908340 |
Herpes zoster | 28.18 | 12.89 | 5 | 44044 | 29938 | 29878491 |
Sinus tachycardia | 28.04 | 12.89 | 67 | 43982 | 15437 | 29892992 |
Angina pectoris | 27.62 | 12.89 | 5 | 44044 | 29513 | 29878916 |
Decreased appetite | 27.59 | 12.89 | 120 | 43929 | 149790 | 29758639 |
Prescribed overdose | 27.51 | 12.89 | 47 | 44002 | 8514 | 29899915 |
Leukopenia | 27.15 | 12.89 | 158 | 43891 | 56001 | 29852428 |
Injection site pain | 26.56 | 12.89 | 6 | 44043 | 30304 | 29878125 |
Gastrointestinal haemorrhage | 26.13 | 12.89 | 52 | 43997 | 83394 | 29825035 |
Haemorrhage | 25.93 | 12.89 | 18 | 44031 | 46061 | 29862368 |
Drug level increased | 25.66 | 12.89 | 72 | 43977 | 18282 | 29890147 |
Arthritis | 25.45 | 12.89 | 3 | 44046 | 24398 | 29884031 |
Mental status changes | 25.38 | 12.89 | 115 | 43934 | 36964 | 29871465 |
Blunted affect | 25.25 | 12.89 | 11 | 44038 | 277 | 29908152 |
Drug withdrawal syndrome neonatal | 25.06 | 12.89 | 27 | 44022 | 3148 | 29905281 |
Antipsychotic drug level above therapeutic | 25.03 | 12.89 | 17 | 44032 | 1053 | 29907376 |
Obesity | 24.94 | 12.89 | 45 | 44004 | 8510 | 29899919 |
Chorea | 24.73 | 12.89 | 17 | 44032 | 1074 | 29907355 |
Hypoaesthesia | 24.64 | 12.89 | 26 | 44023 | 54204 | 29854225 |
HIV peripheral neuropathy | 24.43 | 12.89 | 7 | 44042 | 47 | 29908382 |
Exhibitionism | 24.31 | 12.89 | 7 | 44042 | 48 | 29908381 |
Muscle contracture | 24.03 | 12.89 | 17 | 44032 | 1125 | 29907304 |
Posturing | 24.00 | 12.89 | 13 | 44036 | 533 | 29907896 |
Abdominal discomfort | 23.77 | 12.89 | 22 | 44027 | 48769 | 29859660 |
Type 2 diabetes mellitus | 23.71 | 12.89 | 58 | 43991 | 13564 | 29894865 |
Musculoskeletal pain | 23.61 | 12.89 | 8 | 44041 | 30932 | 29877497 |
Acute myocardial infarction | 23.37 | 12.89 | 26 | 44023 | 52913 | 29855516 |
Muscle contractions involuntary | 23.36 | 12.89 | 20 | 44029 | 1753 | 29906676 |
Malaise | 23.24 | 12.89 | 147 | 43902 | 166815 | 29741614 |
Disease progression | 23.14 | 12.89 | 52 | 43997 | 79822 | 29828607 |
Stomatitis | 23.13 | 12.89 | 13 | 44036 | 37266 | 29871163 |
Accidental exposure to product | 23.12 | 12.89 | 48 | 44001 | 10067 | 29898362 |
Galactorrhoea | 23.05 | 12.89 | 11 | 44038 | 344 | 29908085 |
Tension | 23.01 | 12.89 | 19 | 44030 | 1584 | 29906845 |
Hallucinations, mixed | 22.98 | 12.89 | 23 | 44026 | 2460 | 29905969 |
Vascular stenosis | 22.91 | 12.89 | 9 | 44040 | 173 | 29908256 |
Pancytopenia | 22.56 | 12.89 | 58 | 43991 | 84994 | 29823435 |
Leukocytosis | 22.29 | 12.89 | 76 | 43973 | 21426 | 29887003 |
Cytomegalovirus infection | 22.17 | 12.89 | 4 | 44045 | 23670 | 29884759 |
Myalgia | 22.14 | 12.89 | 50 | 43999 | 76617 | 29831812 |
Gaze palsy | 21.98 | 12.89 | 16 | 44033 | 1108 | 29907321 |
Fluid retention | 21.80 | 12.89 | 5 | 44044 | 24993 | 29883436 |
Snoring | 21.79 | 12.89 | 24 | 44025 | 2867 | 29905562 |
Aspiration | 21.74 | 12.89 | 48 | 44001 | 10503 | 29897926 |
Foetal alcohol syndrome | 21.66 | 12.89 | 9 | 44040 | 201 | 29908228 |
Paraesthesia | 21.54 | 12.89 | 29 | 44020 | 54298 | 29854131 |
Unresponsive to stimuli | 21.21 | 12.89 | 86 | 43963 | 26333 | 29882096 |
Apathy | 21.07 | 12.89 | 35 | 44014 | 6197 | 29902232 |
Generalised tonic-clonic seizure | 21.06 | 12.89 | 70 | 43979 | 19481 | 29888948 |
Physical assault | 20.89 | 12.89 | 16 | 44033 | 1197 | 29907232 |
Intentional product use issue | 20.82 | 12.89 | 14 | 44035 | 36426 | 29872003 |
Hyperkalaemia | 20.77 | 12.89 | 41 | 44008 | 65969 | 29842460 |
Withdrawal syndrome | 20.76 | 12.89 | 49 | 44000 | 11201 | 29897228 |
Drop attacks | 20.68 | 12.89 | 12 | 44037 | 563 | 29907866 |
Thrombosis | 20.62 | 12.89 | 19 | 44030 | 42212 | 29866217 |
Agranulocytosis | 20.54 | 12.89 | 75 | 43974 | 21867 | 29886562 |
Inappropriate affect | 20.54 | 12.89 | 12 | 44037 | 570 | 29907859 |
Sexual abuse | 20.40 | 12.89 | 8 | 44041 | 153 | 29908276 |
Wheezing | 20.36 | 12.89 | 10 | 44039 | 30928 | 29877501 |
Diet refusal | 20.32 | 12.89 | 10 | 44039 | 335 | 29908094 |
Flight of ideas | 20.00 | 12.89 | 10 | 44039 | 347 | 29908082 |
Reduced facial expression | 19.71 | 12.89 | 13 | 44036 | 767 | 29907662 |
Suicidal ideation | 19.71 | 12.89 | 105 | 43944 | 36009 | 29872420 |
Renal impairment | 19.67 | 12.89 | 61 | 43988 | 84123 | 29824306 |
Hypokinesia | 19.67 | 12.89 | 37 | 44012 | 7223 | 29901206 |
Dextrocardia | 19.66 | 12.89 | 8 | 44041 | 169 | 29908260 |
Antidepressant drug level increased | 19.54 | 12.89 | 7 | 44042 | 103 | 29908326 |
Weight decreased | 19.42 | 12.89 | 136 | 43913 | 150785 | 29757644 |
Perseveration | 19.41 | 12.89 | 7 | 44042 | 105 | 29908324 |
Antisocial behaviour | 19.14 | 12.89 | 9 | 44040 | 272 | 29908157 |
Completed suicide | 19.08 | 12.89 | 227 | 43822 | 99265 | 29809164 |
Speech sound disorder | 19.02 | 12.89 | 6 | 44043 | 58 | 29908371 |
Sudden death | 18.99 | 12.89 | 58 | 43991 | 15434 | 29892995 |
Acute kidney injury | 18.99 | 12.89 | 286 | 43763 | 273556 | 29634873 |
Mydriasis | 18.79 | 12.89 | 33 | 44016 | 6110 | 29902319 |
Posture abnormal | 18.62 | 12.89 | 18 | 44031 | 1846 | 29906583 |
Echolalia | 18.49 | 12.89 | 8 | 44041 | 198 | 29908231 |
Condition aggravated | 18.47 | 12.89 | 295 | 43754 | 137571 | 29770858 |
Unevaluable event | 18.44 | 12.89 | 12 | 44037 | 31773 | 29876656 |
Intentional product misuse | 18.38 | 12.89 | 100 | 43949 | 34567 | 29873862 |
Thinking abnormal | 18.19 | 12.89 | 30 | 44019 | 5281 | 29903148 |
Postoperative respiratory failure | 18.17 | 12.89 | 6 | 44043 | 68 | 29908361 |
Encephalitis toxic | 18.14 | 12.89 | 7 | 44042 | 128 | 29908301 |
Reversible splenial lesion syndrome | 18.08 | 12.89 | 5 | 44044 | 29 | 29908400 |
Floppy iris syndrome | 18.00 | 12.89 | 9 | 44040 | 312 | 29908117 |
Resting tremor | 17.95 | 12.89 | 11 | 44038 | 571 | 29907858 |
Productive cough | 17.80 | 12.89 | 11 | 44038 | 29942 | 29878487 |
Ascites | 17.73 | 12.89 | 16 | 44033 | 35905 | 29872524 |
Skin lesion | 17.59 | 12.89 | 3 | 44046 | 18491 | 29889938 |
Neutrophil count increased | 17.52 | 12.89 | 56 | 43993 | 15267 | 29893162 |
Parkinsonian gait | 17.39 | 12.89 | 10 | 44039 | 461 | 29907968 |
Inappropriate antidiuretic hormone secretion | 17.15 | 12.89 | 46 | 44003 | 11376 | 29897053 |
Foetal arrhythmia | 16.95 | 12.89 | 6 | 44043 | 85 | 29908344 |
Hyponatraemia | 16.94 | 12.89 | 162 | 43887 | 67040 | 29841389 |
Rabbit syndrome | 16.82 | 12.89 | 4 | 44045 | 11 | 29908418 |
Gender dysphoria | 16.80 | 12.89 | 5 | 44044 | 39 | 29908390 |
Musculoskeletal stiffness | 16.72 | 12.89 | 100 | 43949 | 35781 | 29872648 |
Primary familial brain calcification | 16.57 | 12.89 | 3 | 44046 | 0 | 29908429 |
Hyperhidrosis | 16.55 | 12.89 | 161 | 43888 | 66929 | 29841500 |
Dysphoria | 16.48 | 12.89 | 18 | 44031 | 2130 | 29906299 |
Rhinorrhoea | 16.48 | 12.89 | 5 | 44044 | 20749 | 29887680 |
Pneumonitis | 16.43 | 12.89 | 10 | 44039 | 27444 | 29880985 |
Dysgeusia | 16.35 | 12.89 | 8 | 44041 | 24793 | 29883636 |
Judgement impaired | 16.33 | 12.89 | 11 | 44038 | 672 | 29907757 |
Cerebrovascular stenosis | 16.23 | 12.89 | 6 | 44043 | 97 | 29908332 |
Hyperventilation | 16.20 | 12.89 | 19 | 44030 | 2430 | 29905999 |
Irritability | 16.15 | 12.89 | 72 | 43977 | 22978 | 29885451 |
Communication disorder | 16.13 | 12.89 | 18 | 44031 | 2182 | 29906247 |
Colitis | 16.10 | 12.89 | 13 | 44036 | 30807 | 29877622 |
Hypersexuality | 16.07 | 12.89 | 15 | 44034 | 1472 | 29906957 |
Haematochezia | 16.01 | 12.89 | 16 | 44033 | 34206 | 29874223 |
Myelodysplastic syndrome | 15.89 | 12.89 | 4 | 44045 | 18774 | 29889655 |
Cyanosis | 15.88 | 12.89 | 46 | 44003 | 11889 | 29896540 |
Malignant neoplasm progression | 15.76 | 12.89 | 54 | 43995 | 72233 | 29836196 |
Mumps | 15.74 | 12.89 | 6 | 44043 | 106 | 29908323 |
Electrocardiogram J wave | 15.68 | 12.89 | 4 | 44045 | 16 | 29908413 |
Seizure | 15.64 | 12.89 | 217 | 43832 | 98258 | 29810171 |
Nasal congestion | 15.63 | 12.89 | 4 | 44045 | 18562 | 29889867 |
Haemoglobin decreased | 15.58 | 12.89 | 101 | 43948 | 113997 | 29794432 |
Impaired self-care | 15.57 | 12.89 | 12 | 44037 | 906 | 29907523 |
Syndactyly | 15.56 | 12.89 | 11 | 44038 | 727 | 29907702 |
Sexual dysfunction | 15.54 | 12.89 | 30 | 44019 | 5971 | 29902458 |
Labile blood pressure | 15.21 | 12.89 | 10 | 44039 | 587 | 29907842 |
Chills | 15.13 | 12.89 | 55 | 43994 | 72283 | 29836146 |
Syncope | 14.97 | 12.89 | 69 | 43980 | 84834 | 29823595 |
Symptom masked | 14.92 | 12.89 | 9 | 44040 | 454 | 29907975 |
Haematuria | 14.85 | 12.89 | 27 | 44022 | 44807 | 29863622 |
Delusional disorder, unspecified type | 14.84 | 12.89 | 11 | 44038 | 783 | 29907646 |
Hyperammonaemia | 14.79 | 12.89 | 28 | 44021 | 5492 | 29902937 |
Schizoaffective disorder bipolar type | 14.73 | 12.89 | 5 | 44044 | 62 | 29908367 |
Cerebral haemorrhage | 14.68 | 12.89 | 16 | 44033 | 32871 | 29875558 |
Pleurothotonus | 14.42 | 12.89 | 12 | 44037 | 1011 | 29907418 |
Ventricular fibrillation | 14.39 | 12.89 | 52 | 43997 | 15086 | 29893343 |
Temporal lobe epilepsy | 14.36 | 12.89 | 6 | 44043 | 136 | 29908293 |
Adactyly | 14.31 | 12.89 | 5 | 44044 | 68 | 29908361 |
Coma scale abnormal | 14.25 | 12.89 | 21 | 44028 | 3355 | 29905074 |
Visual acuity reduced | 14.16 | 12.89 | 3 | 44046 | 15843 | 29892586 |
Cholelithiasis | 14.15 | 12.89 | 6 | 44043 | 20219 | 29888210 |
Multiple organ dysfunction syndrome | 14.13 | 12.89 | 47 | 44002 | 63440 | 29844989 |
Affective disorder | 14.10 | 12.89 | 20 | 44029 | 3088 | 29905341 |
Swollen tongue | 14.00 | 12.89 | 47 | 44002 | 13145 | 29895284 |
Drug-disease interaction | 13.89 | 12.89 | 7 | 44042 | 247 | 29908182 |
Neuroleptic-induced deficit syndrome | 13.82 | 12.89 | 4 | 44045 | 28 | 29908401 |
Differential white blood cell count abnormal | 13.80 | 12.89 | 13 | 44036 | 1291 | 29907138 |
Bacteraemia | 13.79 | 12.89 | 3 | 44046 | 15557 | 29892872 |
Diabetic coma | 13.74 | 12.89 | 11 | 44038 | 878 | 29907551 |
Diabetes mellitus | 13.73 | 12.89 | 107 | 43942 | 41758 | 29866671 |
Coprolalia | 13.70 | 12.89 | 4 | 44045 | 29 | 29908400 |
Rebound effect | 13.61 | 12.89 | 14 | 44035 | 1547 | 29906882 |
Hypersensitivity | 13.45 | 12.89 | 38 | 44011 | 53990 | 29854439 |
Chronic obstructive pulmonary disease | 13.37 | 12.89 | 30 | 44019 | 46096 | 29862333 |
Scrotal haematoma | 13.35 | 12.89 | 5 | 44044 | 84 | 29908345 |
Dyslexia | 13.32 | 12.89 | 6 | 44043 | 164 | 29908265 |
Substance-induced psychotic disorder | 13.24 | 12.89 | 13 | 44036 | 1359 | 29907070 |
Hyporeflexia | 13.19 | 12.89 | 15 | 44034 | 1857 | 29906572 |
Polydipsia | 13.18 | 12.89 | 21 | 44028 | 3592 | 29904837 |
Acute psychosis | 13.16 | 12.89 | 15 | 44034 | 1861 | 29906568 |
Wrong product administered | 13.09 | 12.89 | 24 | 44025 | 4594 | 29903835 |
Incontinence | 13.03 | 12.89 | 26 | 44023 | 5300 | 29903129 |
Renal failure | 13.02 | 12.89 | 124 | 43925 | 128842 | 29779587 |
Breathing-related sleep disorder | 12.96 | 12.89 | 6 | 44043 | 175 | 29908254 |
Victim of crime | 12.95 | 12.89 | 7 | 44042 | 286 | 29908143 |
Paraphilia | 12.93 | 12.89 | 5 | 44044 | 92 | 29908337 |
Cardio-respiratory arrest | 12.91 | 12.89 | 135 | 43914 | 57171 | 29851258 |
Source | Code | Description |
---|---|---|
ATC | N05AD01 | NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Butyrophenone derivatives |
CHEBI has role | CHEBI:48279 | serotonin antagonists |
CHEBI has role | CHEBI:48561 | dopamine blocker |
CHEBI has role | CHEBI:50919 | antiemetico |
CHEBI has role | CHEBI:65190 | typical antipsychotic drug |
CHEBI has role | CHEBI:66956 | antidyskinetic drugs |
MeSH PA | D018726 | Anti-Dyskinesia Agents |
MeSH PA | D000932 | Antiemetics |
MeSH PA | D014150 | Antipsychotic Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D015259 | Dopamine Agents |
MeSH PA | D018492 | Dopamine Antagonists |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D014149 | Tranquilizing Agents |
FDA EPC | N0000180182 | Typical Antipsychotic |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Gilles de la Tourette's syndrome | indication | 5158005 | DOID:11119 |
Schizophrenia | indication | 58214004 | DOID:5419 |
Psychotic disorder | indication | 69322001 | |
Chronic schizophrenia | indication | 83746006 | |
Delirium | off-label use | 2776000 | |
Nausea and vomiting | off-label use | 16932000 | |
Pain | off-label use | 22253000 | |
Anxiety disorder | off-label use | 197480006 | DOID:2030 |
Headache disorder | off-label use | 230461009 | |
Gastroparesis | off-label use | 235675006 | |
Chemotherapy-induced nausea and vomiting | off-label use | 236084000 | |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Senile dementia | contraindication | 15662003 | |
Agranulocytosis | contraindication | 17182001 | DOID:12987 |
Thyrotoxic crisis | contraindication | 29028009 | DOID:12837 |
Torsades de pointes | contraindication | 31722008 | |
Parkinsonism | contraindication | 32798002 | |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Hypokalemia | contraindication | 43339004 | |
Low blood pressure | contraindication | 45007003 | |
Extrapyramidal disease | contraindication | 76349003 | |
Leukopenia | contraindication | 84828003 | DOID:615 |
Tardive dyskinesia | contraindication | 102449007 | |
Prolonged QT interval | contraindication | 111975006 | |
Seizure disorder | contraindication | 128613002 | |
Hypomagnesemia | contraindication | 190855004 | |
Angina pectoris | contraindication | 194828000 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Retention of urine | contraindication | 267064002 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Coma | contraindication | 371632003 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Central nervous system depression | contraindication | 418072004 | |
Acquired torsion dystonia | contraindication | 433493000 | |
Congenital long QT syndrome | contraindication | 442917000 | |
Carcinoma of female breast | contraindication | 447782002 | |
Smokes tobacco daily | contraindication | 449868002 | |
Drug Induced CNS Depression | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.36 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor | GPCR | INVERSE AGONIST | Ki | 9.15 | WOMBAT-PK | CHEMBL | |||
Alpha-1B adrenergic receptor | GPCR | Ki | 8.10 | PDSP | |||||
5-hydroxytryptamine receptor 1B | GPCR | Ki | 6.57 | PDSP | |||||
Histamine H2 receptor | GPCR | Ki | 6.00 | PDSP | |||||
Muscarinic acetylcholine receptor M3 | GPCR | Ki | 5 | PDSP | |||||
Alpha-2C adrenergic receptor | GPCR | Ki | 6.26 | PDSP | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 6.32 | PDSP | |||||
Alpha-2A adrenergic receptor | GPCR | Ki | 5.95 | PDSP | |||||
Muscarinic acetylcholine receptor M5 | GPCR | Ki | 6.18 | PDSP | |||||
5-hydroxytryptamine receptor 1D | GPCR | ANTAGONIST | Ki | 6.60 | IUPHAR | ||||
Potassium voltage-gated channel subfamily H member 1 | Ion channel | BLOCKER | IC50 | 6.20 | IUPHAR | ||||
Mu-type opioid receptor | GPCR | Ki | 6.00 | DRUG MATRIX | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.74 | DRUG MATRIX | |||||
Alpha-1D adrenergic receptor | GPCR | Ki | 7.55 | DRUG MATRIX | |||||
D(3) dopamine receptor | GPCR | INVERSE AGONIST | Ki | 8.52 | WOMBAT-PK | ||||
5-hydroxytryptamine receptor 2A | GPCR | ANTAGONIST | Ki | 7 | WOMBAT-PK | ||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | EC50 | 8.92 | WOMBAT-PK | |||||
Calmodulin | Cytosolic other | IC50 | 6.30 | WOMBAT-PK | |||||
D(1B) dopamine receptor | GPCR | Ki | 7.52 | WOMBAT-PK | |||||
Alpha-1A adrenergic receptor | GPCR | Ki | 7.90 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 7 | GPCR | Ki | 6.45 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 6.10 | WOMBAT-PK | |||||
Multidrug resistance protein 1 | Transporter | Ki | 6.70 | WOMBAT-PK | |||||
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | Enzyme | Ki | 6.72 | WOMBAT-PK | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 7.50 | WOMBAT-PK | |||||
D(1A) dopamine receptor | GPCR | Ki | 7.82 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 5.55 | CHEMBL | |||||
Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | IC50 | 5.92 | CHEMBL | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 5.80 | CHEMBL | |||||
5-hydroxytryptamine receptor 6 | GPCR | Ki | 5.22 | CHEMBL | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 5.33 | CHEMBL | |||||
Histamine H1 receptor | GPCR | Ki | 6.36 | CHEMBL | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 5.74 | CHEMBL | |||||
5-hydroxytryptamine receptor 1E | GPCR | Ki | 5.30 | PDSP | |||||
5-hydroxytryptamine receptor 1F | GPCR | Ki | 5.30 | PDSP | |||||
Beta-2 adrenergic receptor | GPCR | Ki | 5.30 | PDSP | |||||
D(4) dopamine receptor | GPCR | INVERSE AGONIST | Kd | 9.42 | SCIENTIFIC LITERATURE | ||||
5-hydroxytryptamine receptor 5A | GPCR | Ki | 5.65 | PDSP | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 8.31 | DRUG MATRIX | |||||
Membrane-associated progesterone receptor component 1 | Membrane receptor | Ki | 7.44 | DRUG MATRIX | |||||
Transporter | Transporter | Ki | 5.26 | CHEMBL | |||||
Dopamine receptor | GPCR | IC50 | 8.74 | CHEMBL | |||||
5-hydroxytryptamine receptor 7 | GPCR | Ki | 6.58 | CHEMBL | |||||
Muscarinic acetylcholine receptor | GPCR | Ki | 5.13 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | Ki | 9.52 | CHEMBL | |||||
D(3) dopamine receptor | GPCR | Ki | 8.52 | CHEMBL | |||||
Serotonin 2 (5-HT2) receptor | GPCR | Ki | 8.38 | CHEMBL | |||||
Dopamine receptor | GPCR | Ki | 8.70 | CHEMBL | |||||
Adrenergic receptor alpha-2 | GPCR | Ki | 5.57 | CHEMBL | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 7.70 | CHEMBL | |||||
AP-2 complex subunit sigma | Unclassified | Ki | 7.62 | CHEMBL | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 5.74 | CHEMBL | |||||
Adenylate cyclase | Enzyme | IC50 | 5.64 | CHEMBL | |||||
Muscarinic acetylcholine receptor M2 | GPCR | Ki | 6.62 | CHEMBL | |||||
D(3) dopamine receptor | GPCR | Ki | 8.52 | CHEMBL | |||||
Alpha-1A adrenergic receptor | GPCR | Kd | 7.76 | CHEMBL | |||||
Serotonin 1 (5-HT1) receptor | GPCR | IC50 | 4.70 | CHEMBL | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 6.40 | CHEMBL | |||||
D(1A) dopamine receptor | GPCR | Ki | 7.70 | CHEMBL | |||||
Pol polyprotein | Enzyme | Ki | 7 | CHEMBL | |||||
Histamine H1 receptor | GPCR | Ki | 6.42 | CHEMBL | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 7.52 | CHEMBL | |||||
Opioid receptor | GPCR | Ki | 5.92 | CHEMBL | |||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 9.05 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | Ki | 8.32 | CHEMBL | |||||
Serotonin 2 (5-HT2) receptor | GPCR | Ki | 7.58 | CHEMBL | |||||
5-hydroxytryptamine receptor 2A | GPCR | IC50 | 7.52 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | Ki | 9.70 | CHEMBL | |||||
Protease | Enzyme | Ki | 7 | CHEMBL | |||||
D(1A) dopamine receptor | GPCR | Ki | 7.03 | CHEMBL | |||||
Sigma non-opioid intracellular receptor 1 | Membrane other | Ki | 9.08 | CHEMBL | |||||
C-8 sterol isomerase | Enzyme | Ki | 9.30 | CHEMBL | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 7.35 | CHEMBL | |||||
Histamine H1 receptor | GPCR | Ki | 6.40 | CHEMBL | |||||
5-hydroxytryptamine receptor 7 | GPCR | ANTAGONIST | Ki | 6.30 | IUPHAR | ||||
G protein-activated inward rectifier potassium channel 2 | Ion channel | GATING INHIBITOR | EC50 | 4.10 | IUPHAR |
ID | Source |
---|---|
4018123 | VUID |
N0000146461 | NUI |
D00136 | KEGG_DRUG |
53515-91-6 | SECONDARY_CAS_RN |
4018123 | VANDF |
4018125 | VANDF |
C0018546 | UMLSCUI |
CHEBI:5613 | CHEBI |
GMJ | PDB_CHEM_ID |
CHEMBL54 | ChEMBL_ID |
CHEMBL2096643 | ChEMBL_ID |
CHEMBL4297147 | ChEMBL_ID |
DB00502 | DRUGBANK_ID |
3559 | PUBCHEM_CID |
D006220 | MESH_DESCRIPTOR_UI |
86 | IUPHAR_LIGAND_ID |
918 | INN_ID |
J6292F8L3D | UNII |
217483 | RXNORM |
2958 | MMSL |
4816 | MMSL |
4818 | MMSL |
583 | MMSL |
d00027 | MMSL |
001518 | NDDF |
001521 | NDDF |
10756001 | SNOMEDCT_US |
386837002 | SNOMEDCT_US |
412197008 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0581 | SOLUTION | 2 mg | ORAL | ANDA | 17 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9319 | INJECTION | 5 mg | INTRAMUSCULAR | ANDA | 16 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9501 | INJECTION | 5 mg | INTRAMUSCULAR | ANDA | 16 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9502 | INJECTION | 5 mg | INTRAMUSCULAR | ANDA | 16 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0214 | TABLET | 2 mg | ORAL | ANDA | 17 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0257 | TABLET | 1 mg | ORAL | ANDA | 17 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0327 | TABLET | 5 mg | ORAL | ANDA | 17 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0334 | TABLET | 10 mg | ORAL | ANDA | 17 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0335 | TABLET | 20 mg | ORAL | ANDA | 17 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0351 | TABLET | 0.50 mg | ORAL | ANDA | 17 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8355 | TABLET | 5 mg | ORAL | ANDA | 15 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-1510 | TABLET | 0.50 mg | ORAL | ANDA | 15 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-1520 | TABLET | 1 mg | ORAL | ANDA | 15 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-1530 | TABLET | 2 mg | ORAL | ANDA | 15 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-1540 | TABLET | 5 mg | ORAL | ANDA | 15 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-1550 | TABLET | 10 mg | ORAL | ANDA | 15 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-1560 | TABLET | 20 mg | ORAL | ANDA | 15 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5923 | TABLET | 1 mg | ORAL | ANDA | 18 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5924 | TABLET | 2 mg | ORAL | ANDA | 18 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5925 | TABLET | 5 mg | ORAL | ANDA | 18 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6413 | TABLET | 10 mg | ORAL | ANDA | 18 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6661 | TABLET | 20 mg | ORAL | ANDA | 15 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6733 | TABLET | 10 mg | ORAL | ANDA | 15 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6782 | TABLET | 5 mg | ORAL | ANDA | 15 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7112 | SOLUTION | 2 mg | ORAL | ANDA | 13 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10147-0911 | INJECTION | 5 mg | INTRAMUSCULAR | NDA AUTHORIZED GENERIC | 24 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-110 | INJECTION | 5 mg | INTRAMUSCULAR | ANDA | 22 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17856-0501 | SOLUTION | 2 mg | ORAL | ANDA | 13 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17856-0581 | SOLUTION, CONCENTRATE | 2 mg | ORAL | ANDA | 16 sections |
Haloperidol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17856-0730 | TABLET | 5 mg | ORAL | ANDA | 16 sections |