moperone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
tranquillizers, neuroleptics, 4'-fluoro-4-piperidinobutyrophenone derivatives 1837 1050-79-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • moperone hydrochloride
  • moperone
  • luvatren
  • luvatrena
  • meperon
  • methylperidol
  • moperone HCl
  • Molecular weight: 355.45
  • Formula: C22H26FNO2
  • CLOGP: 3.63
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 40.54
  • ALOGS: -4.54
  • ROTB: 6

Drug dosage:

DoseUnitRoute
20 mg O
20 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.613 Moderate 0.79
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.995 Moderate 0.79
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 21.928 10^-6 cm/s Moderate 0.79
dh-clint Dog hepatocyte intrinsic clearance 37.154 uL/min/10^6 cells Moderate 0.79
dppb Dog plasma protein binding (% unbound) 20.080 % Moderate 0.79
fcs-ppb Fetal calf serum protein binding (% unbound) 43.870 % Moderate 0.79
herg hERG pIC50 6.470 pIC50 Moderate 0.79
hh-clint Human hepatocyte intrinsic clearance 9.078 uL/min/10^6 cells Moderate 0.79
hlm-clint Human liver microsomal intrinsic clearance 42.855 uL/min/mg protein Moderate 0.79
hppb Human plasma protein binding (% unbound) 17.880 % Moderate 0.79
kinase-safety-class ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK 46
kinase-selectivity-class AKT2,AKT3,AXL,EIF2AK3,EPHB4,ERBB2,GRK2,PDK4,PRKCD,SIK2 10
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.482 Moderate 0.79
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.767 Moderate 0.79
mh-clint Mouse hepatocyte intrinsic clearance 87.902 Moderate 0.79
mppb Mouse plasma protein binding (% unbound) 21.210 Moderate 0.79
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 2.089 Moderate 0.79
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 Moderate 0.79
pppb Pig plasma protein binding (% unbound) 37.380 % Moderate 0.79
rat-kpuu-brain Rat brain Kpuu 0.071 % Moderate 0.79
rh-clint Rat hepatocyte intrinsic clearance 207.491 uL/min/10^6 cells Moderate 0.79
rh-fuinc Rat hepatocyte fraction unbound in incubation 45.580 % Moderate 0.79
rppb Rat plasma protein binding (% unbound) 20.110 % Moderate 0.79
solubility-dd Solubility at pH 7.4 in DMSO 173.380 uM Moderate 0.79

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AD04 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Butyrophenone derivatives
CHEBI has role CHEBI:35476 antipsychotic agent

Related Drugs by ATC class:

N05AD Butyrophenone derivatives 8 drugs
benperidolbromperidoldroperidolhaloperidollumateperonemelperonepipamperonetrifluperidol

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.36 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
D(2) dopamine receptor GPCR Ki 9 PDSP
D(3) dopamine receptor GPCR Ki 9.50 PDSP
D(4) dopamine receptor GPCR Ki 8.13 PDSP

External reference:

IDSource
D01105 KEGG_DRUG
3871-82-7 SECONDARY_CAS_RN
C0066787 UMLSCUI
CHEBI:135500 CHEBI
CHEMBL2104700 ChEMBL_ID
DB13554 DRUGBANK_ID
C005209 MESH_SUPPLEMENTAL_RECORD_UI
4249 PUBCHEM_CID
1589 INN_ID
OU730881W5 UNII
005973 NDDF
005974 NDDF
OU730881W5 INXIGHT DRUGS

Pharmaceutical products:

None