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pipamperone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
tranquillizers, neuroleptics, 4'-fluoro-4-piperidinobutyrophenone derivatives	2181	1893-33-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: pipamperone dihydrochloride pipamperone dipiperon dipiperone floropipamide dipiperal pipamperone hydrochloride pipamperone HCl	Molecular weight: 375.49 Formula: C21H30FN3O2 CLOGP: 2.24 LIPINSKI: 0 HAC: 5 HDO: 1 TPSA: 66.64 ALOGS: -3.31 ROTB: 7

Molecule

Description

Molfile Inchi Smiles

Synonyms:

pipamperone dihydrochloride
pipamperone
dipiperon
dipiperone
floropipamide
dipiperal
pipamperone hydrochloride
pipamperone HCl

Molecular weight: 375.49
Formula: C21H30FN3O2
CLOGP: 2.24
LIPINSKI: 0
HAC: 5
HDO: 1
TPSA: 66.64
ALOGS: -3.31
ROTB: 7

Drug dosage:

Dose	Unit	Route
0.20	g	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	156.21	41.49	112	3500	201290	63284120
Product prescribing error	120.29	41.49	48	3564	26241	63459169
Tachycardia	94.28	41.49	67	3545	118089	63367321
Fall	90.47	41.49	111	3501	392223	63093187
Hypothermia	88.07	41.49	32	3580	13549	63471861
Restlessness	85.62	41.49	39	3573	29414	63455996
Labelled drug-drug interaction medication error	77.40	41.49	29	3583	13370	63472040
Dysarthria	71.87	41.49	39	3573	42672	63442738
Drug interaction	71.58	41.49	76	3536	229055	63256355
Rhonchi	68.78	41.49	18	3594	2558	63482852

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cerebral artery thrombosis	105.19	34.41	22	3040	758	34953111
Brain scan abnormal	102.54	34.41	22	3040	858	34953011
Areflexia	84.46	34.41	24	3038	3007	34950862
Product monitoring error	79.90	34.41	25	3037	4356	34949513
Pleurothotonus	74.66	34.41	18	3044	1187	34952682
General physical health deterioration	71.72	34.41	71	2991	128198	34825671
Wrong patient received product	64.96	34.41	19	3043	2635	34951234
Bradyarrhythmia	63.98	34.41	18	3044	2173	34951696
Fall	63.40	34.41	83	2979	202802	34751067
Neuroleptic malignant syndrome	60.19	34.41	30	3032	17904	34935965

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	229.22	36.26	182	6090	275056	79463060
Fall	157.51	36.26	192	6080	487437	79250679
Product prescribing error	134.16	36.26	67	6205	44746	79693370
Product monitoring error	110.58	36.26	37	6235	8869	79729247
Restlessness	106.20	36.26	58	6214	46434	79691682
Labelled drug-drug interaction medication error	99.78	36.26	47	6225	27603	79710513
Brain scan abnormal	92.24	36.26	21	6251	1202	79736914
Pleurothotonus	91.40	36.26	24	6248	2492	79735624
Drug interaction	90.10	36.26	135	6137	415048	79323068
Cerebral artery thrombosis	88.78	36.26	20	6252	1091	79737025

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	N05AD05	NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Butyrophenone derivatives
CHEBI has role	CHEBI:48279	serotonin antagonists
CHEBI has role	CHEBI:48561	dopaminergic antagonists
CHEBI has role	CHEBI:65190	typical antipsychotic drugs
MeSH PA	D014150	Antipsychotic Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D018490	Serotonin Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.93	Basic
pKa2	6.19	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source
Beta-1 adrenergic receptor	GPCR	P08588	ADRB1_HUMAN		Ki	5.30	PDSP
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN		Ki	5.30	PDSP
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	6.94	PDSP
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	6.07	PDSP
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN	ANTAGONIST	Ki	5.60	IUPHAR
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN	ANTAGONIST	Ki	8.30	IUPHAR
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	7.32	PDSP
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	6.64	PDSP
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	7.46	PDSP
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	6.60	PDSP

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External reference:

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ID	Source
005709	NDDF
005710	NDDF
1588	INN_ID
2448-68-2	SECONDARY_CAS_RN
289159	RXNORM
4830	PUBCHEM_CID
5402501F0W	UNII
703362007	SNOMEDCT_US
703363002	SNOMEDCT_US
703364008	SNOMEDCT_US

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Pharmaceutical products:

None