pipamperone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
tranquillizers, neuroleptics, 4'-fluoro-4-piperidinobutyrophenone derivatives 2181 1893-33-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pipamperone dihydrochloride
  • pipamperone
  • dipiperon
  • dipiperone
  • floropipamide
  • dipiperal
  • pipamperone hydrochloride
  • pipamperone HCl
  • Molecular weight: 375.49
  • Formula: C21H30FN3O2
  • CLOGP: 2.24
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 66.64
  • ALOGS: -3.31
  • ROTB: 7

Drug dosage:

DoseUnitRoute
0.20 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 112.42 43.08 80 2790 142354 50459900
Fall 93.10 43.08 104 2766 334828 50267426
Hypothermia 92.03 43.08 32 2838 11984 50590270
Product prescribing error 84.77 43.08 35 2835 20926 50581328
Drug interaction 80.77 43.08 76 2794 199545 50402709
Restlessness 75.40 43.08 34 2836 25139 50577115
Rhonchi 70.82 43.08 18 2852 2289 50599965
Facial nerve disorder 65.58 43.08 13 2857 533 50601721
Electrocardiogram ST-T segment abnormal 55.62 43.08 10 2860 240 50602014
Tachycardia 54.24 43.08 45 2825 99718 50502536
Cerebrospinal fluid retention 50.96 43.08 8 2862 81 50602173
Brain contusion 47.90 43.08 10 2860 532 50601722
Labelled drug-drug interaction medication error 47.49 43.08 19 2851 10458 50591796
Coma 47.12 43.08 33 2837 56846 50545408
Suicide attempt 45.16 43.08 31 2839 51701 50550553
Vascular encephalopathy 45.11 43.08 9 2861 381 50601873
Subileus 44.64 43.08 13 2857 2746 50599508
Cerebral ventricular rupture 44.33 43.08 8 2862 196 50602058

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cerebral artery thrombosis 106.23 34.77 22 2576 720 29571209
Brain scan abnormal 103.25 34.77 22 2576 828 29571101
Areflexia 86.68 34.77 24 2574 2730 29569199
Bradyarrhythmia 65.70 34.77 18 2580 1967 29569962
Neuroleptic malignant syndrome 63.12 34.77 30 2568 16118 29555811
Product monitoring error 56.26 34.77 17 2581 2628 29569301
Hemiplegia 51.49 34.77 20 2578 6574 29565355
Fall 49.87 34.77 69 2529 177109 29394820
Ischaemic stroke 48.51 34.77 25 2573 15952 29555977
Facial paralysis 47.37 34.77 21 2577 9608 29562321
Pleurothotonus 46.68 34.77 12 2586 1026 29570903
Congenital cystic kidney disease 46.64 34.77 10 2588 387 29571542
Wound 45.87 34.77 22 2576 12041 29559888
Drug withdrawal convulsions 45.34 34.77 12 2586 1149 29570780
Depressed level of consciousness 42.36 34.77 31 2567 36911 29535018
Renal aplasia 41.49 34.77 10 2588 656 29571273
Disease recurrence 40.11 34.77 22 2576 15892 29556037
Conduction disorder 39.88 34.77 12 2586 1828 29570101
Heart disease congenital 39.55 34.77 11 2587 1269 29570660
Hangover 37.69 34.77 10 2588 967 29570962
Withdrawal syndrome 35.68 34.77 18 2580 10974 29560955
General physical health deterioration 34.93 34.77 44 2554 102813 29469116

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Fall 144.86 35.87 172 5008 416654 64076898
General physical health deterioration 142.23 35.87 123 5057 204302 64289250
Brain scan abnormal 92.77 35.87 21 5159 1147 64492405
Restlessness 90.93 35.87 50 5130 39735 64453817
Cerebral artery thrombosis 89.33 35.87 20 5160 1039 64492513
Product prescribing error 88.04 35.87 47 5133 35222 64458330
Wound 87.79 35.87 62 5118 76415 64417137
Drug interaction 82.87 35.87 122 5058 361961 64131591
Depressed level of consciousness 73.20 35.87 57 5123 81379 64412173
Areflexia 70.52 35.87 23 5157 4984 64488568
Pleurothotonus 69.24 35.87 19 5161 2283 64491269
Hypothermia 68.68 35.87 33 5147 19823 64473729
Neuroleptic malignant syndrome 61.49 35.87 33 5147 24963 64468589
Facial nerve disorder 58.39 35.87 13 5167 658 64492894
Product monitoring error 56.90 35.87 20 5160 5434 64488118
Bradyarrhythmia 55.92 35.87 18 5162 3740 64489812
Labelled drug-drug interaction medication error 53.91 35.87 29 5151 22033 64471519
Rhonchi 53.23 35.87 17 5163 3446 64490106
Dysarthria 52.09 35.87 41 5139 59365 64434187
Wrong product administered 50.13 35.87 20 5160 7700 64485852
Cerebrospinal fluid retention 48.73 35.87 8 5172 75 64493477
Myoclonus 45.12 35.87 27 5153 25091 64468461
Coma 43.82 35.87 44 5136 87571 64405981
Electrocardiogram QT prolonged 43.65 35.87 42 5138 79406 64414146
Drug withdrawal convulsions 39.20 35.87 12 5168 2116 64491436
Vascular encephalopathy 38.55 35.87 9 5171 563 64492989
Hemiplegia 37.52 35.87 19 5161 12749 64480803
Rabbit syndrome 37.29 35.87 8 5172 340 64493212
Arrhythmia 36.91 35.87 32 5148 52912 64440640
Wrong patient received product 36.22 35.87 13 5167 3749 64489803
Brain contusion 36.21 35.87 10 5170 1229 64492323

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AD05 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Butyrophenone derivatives
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D012702 Serotonin Antagonists
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:48279 serotonin antagonists
CHEBI has role CHEBI:48561 dopaminergic antagonists
CHEBI has role CHEBI:65190 typical antipsychotic drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.93 Basic
pKa2 6.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
Beta-2 adrenergic receptor GPCR Ki 5.30 PDSP
D(2) dopamine receptor GPCR Ki 6.94 PDSP
Alpha-2A adrenergic receptor GPCR Ki 6.07 PDSP
5-hydroxytryptamine receptor 1A GPCR ANTAGONIST Ki 5.60 IUPHAR
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 8.30 IUPHAR
5-hydroxytryptamine receptor 2B GPCR Ki 7.32 PDSP
5-hydroxytryptamine receptor 2C GPCR Ki 6.64 PDSP
Alpha-2B adrenergic receptor GPCR Ki 7.46 PDSP
D(3) dopamine receptor GPCR Ki 6.60 PDSP
Histamine H1 receptor GPCR ANTAGONIST Ki 5.60 IUPHAR
5-hydroxytryptamine receptor 1B GPCR ANTAGONIST Ki 6.20 IUPHAR
5-hydroxytryptamine receptor 1D GPCR ANTAGONIST Ki 6.80 IUPHAR
Alpha-2C adrenergic receptor GPCR Ki 6.54 PDSP
5-hydroxytryptamine receptor 1F GPCR Ki 5.30 PDSP
5-hydroxytryptamine receptor 1E GPCR Ki 5.30 PDSP

External reference:

IDSource
D01482 KEGG_DRUG
2448-68-2 SECONDARY_CAS_RN
C0071098 UMLSCUI
CHEBI:78549 CHEBI
CHEMBL440294 ChEMBL_ID
DB09286 DRUGBANK_ID
C005569 MESH_SUPPLEMENTAL_RECORD_UI
4830 PUBCHEM_CID
92 IUPHAR_LIGAND_ID
1588 INN_ID
5402501F0W UNII
289159 RXNORM
005709 NDDF
005710 NDDF
703362007 SNOMEDCT_US
703363002 SNOMEDCT_US
703364008 SNOMEDCT_US

Pharmaceutical products:

None