Stem definition | Drug id | CAS RN |
---|---|---|
tranquillizers, neuroleptics, 4'-fluoro-4-piperidinobutyrophenone derivatives | 2181 | 1893-33-0 |
Dose | Unit | Route |
---|---|---|
0.20 | g | O |
None
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
General physical health deterioration | 112.42 | 43.08 | 80 | 2790 | 142354 | 50459900 |
Fall | 93.10 | 43.08 | 104 | 2766 | 334828 | 50267426 |
Hypothermia | 92.03 | 43.08 | 32 | 2838 | 11984 | 50590270 |
Product prescribing error | 84.77 | 43.08 | 35 | 2835 | 20926 | 50581328 |
Drug interaction | 80.77 | 43.08 | 76 | 2794 | 199545 | 50402709 |
Restlessness | 75.40 | 43.08 | 34 | 2836 | 25139 | 50577115 |
Rhonchi | 70.82 | 43.08 | 18 | 2852 | 2289 | 50599965 |
Facial nerve disorder | 65.58 | 43.08 | 13 | 2857 | 533 | 50601721 |
Electrocardiogram ST-T segment abnormal | 55.62 | 43.08 | 10 | 2860 | 240 | 50602014 |
Tachycardia | 54.24 | 43.08 | 45 | 2825 | 99718 | 50502536 |
Cerebrospinal fluid retention | 50.96 | 43.08 | 8 | 2862 | 81 | 50602173 |
Brain contusion | 47.90 | 43.08 | 10 | 2860 | 532 | 50601722 |
Labelled drug-drug interaction medication error | 47.49 | 43.08 | 19 | 2851 | 10458 | 50591796 |
Coma | 47.12 | 43.08 | 33 | 2837 | 56846 | 50545408 |
Suicide attempt | 45.16 | 43.08 | 31 | 2839 | 51701 | 50550553 |
Vascular encephalopathy | 45.11 | 43.08 | 9 | 2861 | 381 | 50601873 |
Subileus | 44.64 | 43.08 | 13 | 2857 | 2746 | 50599508 |
Cerebral ventricular rupture | 44.33 | 43.08 | 8 | 2862 | 196 | 50602058 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Cerebral artery thrombosis | 106.23 | 34.77 | 22 | 2576 | 720 | 29571209 |
Brain scan abnormal | 103.25 | 34.77 | 22 | 2576 | 828 | 29571101 |
Areflexia | 86.68 | 34.77 | 24 | 2574 | 2730 | 29569199 |
Bradyarrhythmia | 65.70 | 34.77 | 18 | 2580 | 1967 | 29569962 |
Neuroleptic malignant syndrome | 63.12 | 34.77 | 30 | 2568 | 16118 | 29555811 |
Product monitoring error | 56.26 | 34.77 | 17 | 2581 | 2628 | 29569301 |
Hemiplegia | 51.49 | 34.77 | 20 | 2578 | 6574 | 29565355 |
Fall | 49.87 | 34.77 | 69 | 2529 | 177109 | 29394820 |
Ischaemic stroke | 48.51 | 34.77 | 25 | 2573 | 15952 | 29555977 |
Facial paralysis | 47.37 | 34.77 | 21 | 2577 | 9608 | 29562321 |
Pleurothotonus | 46.68 | 34.77 | 12 | 2586 | 1026 | 29570903 |
Congenital cystic kidney disease | 46.64 | 34.77 | 10 | 2588 | 387 | 29571542 |
Wound | 45.87 | 34.77 | 22 | 2576 | 12041 | 29559888 |
Drug withdrawal convulsions | 45.34 | 34.77 | 12 | 2586 | 1149 | 29570780 |
Depressed level of consciousness | 42.36 | 34.77 | 31 | 2567 | 36911 | 29535018 |
Renal aplasia | 41.49 | 34.77 | 10 | 2588 | 656 | 29571273 |
Disease recurrence | 40.11 | 34.77 | 22 | 2576 | 15892 | 29556037 |
Conduction disorder | 39.88 | 34.77 | 12 | 2586 | 1828 | 29570101 |
Heart disease congenital | 39.55 | 34.77 | 11 | 2587 | 1269 | 29570660 |
Hangover | 37.69 | 34.77 | 10 | 2588 | 967 | 29570962 |
Withdrawal syndrome | 35.68 | 34.77 | 18 | 2580 | 10974 | 29560955 |
General physical health deterioration | 34.93 | 34.77 | 44 | 2554 | 102813 | 29469116 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Fall | 144.86 | 35.87 | 172 | 5008 | 416654 | 64076898 |
General physical health deterioration | 142.23 | 35.87 | 123 | 5057 | 204302 | 64289250 |
Brain scan abnormal | 92.77 | 35.87 | 21 | 5159 | 1147 | 64492405 |
Restlessness | 90.93 | 35.87 | 50 | 5130 | 39735 | 64453817 |
Cerebral artery thrombosis | 89.33 | 35.87 | 20 | 5160 | 1039 | 64492513 |
Product prescribing error | 88.04 | 35.87 | 47 | 5133 | 35222 | 64458330 |
Wound | 87.79 | 35.87 | 62 | 5118 | 76415 | 64417137 |
Drug interaction | 82.87 | 35.87 | 122 | 5058 | 361961 | 64131591 |
Depressed level of consciousness | 73.20 | 35.87 | 57 | 5123 | 81379 | 64412173 |
Areflexia | 70.52 | 35.87 | 23 | 5157 | 4984 | 64488568 |
Pleurothotonus | 69.24 | 35.87 | 19 | 5161 | 2283 | 64491269 |
Hypothermia | 68.68 | 35.87 | 33 | 5147 | 19823 | 64473729 |
Neuroleptic malignant syndrome | 61.49 | 35.87 | 33 | 5147 | 24963 | 64468589 |
Facial nerve disorder | 58.39 | 35.87 | 13 | 5167 | 658 | 64492894 |
Product monitoring error | 56.90 | 35.87 | 20 | 5160 | 5434 | 64488118 |
Bradyarrhythmia | 55.92 | 35.87 | 18 | 5162 | 3740 | 64489812 |
Labelled drug-drug interaction medication error | 53.91 | 35.87 | 29 | 5151 | 22033 | 64471519 |
Rhonchi | 53.23 | 35.87 | 17 | 5163 | 3446 | 64490106 |
Dysarthria | 52.09 | 35.87 | 41 | 5139 | 59365 | 64434187 |
Wrong product administered | 50.13 | 35.87 | 20 | 5160 | 7700 | 64485852 |
Cerebrospinal fluid retention | 48.73 | 35.87 | 8 | 5172 | 75 | 64493477 |
Myoclonus | 45.12 | 35.87 | 27 | 5153 | 25091 | 64468461 |
Coma | 43.82 | 35.87 | 44 | 5136 | 87571 | 64405981 |
Electrocardiogram QT prolonged | 43.65 | 35.87 | 42 | 5138 | 79406 | 64414146 |
Drug withdrawal convulsions | 39.20 | 35.87 | 12 | 5168 | 2116 | 64491436 |
Vascular encephalopathy | 38.55 | 35.87 | 9 | 5171 | 563 | 64492989 |
Hemiplegia | 37.52 | 35.87 | 19 | 5161 | 12749 | 64480803 |
Rabbit syndrome | 37.29 | 35.87 | 8 | 5172 | 340 | 64493212 |
Arrhythmia | 36.91 | 35.87 | 32 | 5148 | 52912 | 64440640 |
Wrong patient received product | 36.22 | 35.87 | 13 | 5167 | 3749 | 64489803 |
Brain contusion | 36.21 | 35.87 | 10 | 5170 | 1229 | 64492323 |
None
Source | Code | Description |
---|---|---|
ATC | N05AD05 | NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Butyrophenone derivatives |
MeSH PA | D014150 | Antipsychotic Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D018490 | Serotonin Agents |
MeSH PA | D012702 | Serotonin Antagonists |
MeSH PA | D014149 | Tranquilizing Agents |
CHEBI has role | CHEBI:48279 | serotonin antagonists |
CHEBI has role | CHEBI:48561 | dopaminergic antagonists |
CHEBI has role | CHEBI:65190 | typical antipsychotic drugs |
None
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.93 | Basic |
pKa2 | 6.19 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Beta-1 adrenergic receptor | GPCR | Ki | 5.30 | PDSP | |||||
Beta-2 adrenergic receptor | GPCR | Ki | 5.30 | PDSP | |||||
D(2) dopamine receptor | GPCR | Ki | 6.94 | PDSP | |||||
Alpha-2A adrenergic receptor | GPCR | Ki | 6.07 | PDSP | |||||
5-hydroxytryptamine receptor 1A | GPCR | ANTAGONIST | Ki | 5.60 | IUPHAR | ||||
5-hydroxytryptamine receptor 2A | GPCR | ANTAGONIST | Ki | 8.30 | IUPHAR | ||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 7.32 | PDSP | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 6.64 | PDSP | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 7.46 | PDSP | |||||
D(3) dopamine receptor | GPCR | Ki | 6.60 | PDSP | |||||
Histamine H1 receptor | GPCR | ANTAGONIST | Ki | 5.60 | IUPHAR | ||||
5-hydroxytryptamine receptor 1B | GPCR | ANTAGONIST | Ki | 6.20 | IUPHAR | ||||
5-hydroxytryptamine receptor 1D | GPCR | ANTAGONIST | Ki | 6.80 | IUPHAR | ||||
Alpha-2C adrenergic receptor | GPCR | Ki | 6.54 | PDSP | |||||
5-hydroxytryptamine receptor 1F | GPCR | Ki | 5.30 | PDSP | |||||
5-hydroxytryptamine receptor 1E | GPCR | Ki | 5.30 | PDSP |
ID | Source |
---|---|
D01482 | KEGG_DRUG |
2448-68-2 | SECONDARY_CAS_RN |
C0071098 | UMLSCUI |
CHEBI:78549 | CHEBI |
CHEMBL440294 | ChEMBL_ID |
DB09286 | DRUGBANK_ID |
C005569 | MESH_SUPPLEMENTAL_RECORD_UI |
4830 | PUBCHEM_CID |
92 | IUPHAR_LIGAND_ID |
1588 | INN_ID |
5402501F0W | UNII |
289159 | RXNORM |
005709 | NDDF |
005710 | NDDF |
703362007 | SNOMEDCT_US |
703363002 | SNOMEDCT_US |
703364008 | SNOMEDCT_US |
None