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pipamperone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
tranquillizers, neuroleptics, 4'-fluoro-4-piperidinobutyrophenone derivatives	2181	1893-33-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: pipamperone dihydrochloride pipamperone dipiperon dipiperone floropipamide dipiperal pipamperone hydrochloride pipamperone HCl	Molecular weight: 375.49 Formula: C21H30FN3O2 CLOGP: 2.24 LIPINSKI: 0 HAC: 5 HDO: 1 TPSA: 66.64 ALOGS: -3.31 ROTB: 7

Molecule

Description

Molfile Inchi Smiles

Synonyms:

pipamperone dihydrochloride
pipamperone
dipiperon
dipiperone
floropipamide
dipiperal
pipamperone hydrochloride
pipamperone HCl

Molecular weight: 375.49
Formula: C21H30FN3O2
CLOGP: 2.24
LIPINSKI: 0
HAC: 5
HDO: 1
TPSA: 66.64
ALOGS: -3.31
ROTB: 7

Drug dosage:

Dose	Unit	Route
0.20	g	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	156.21	41.49	112	3500	201290	63284120
Product prescribing error	120.29	41.49	48	3564	26241	63459169
Tachycardia	94.28	41.49	67	3545	118089	63367321
Fall	90.47	41.49	111	3501	392223	63093187
Hypothermia	88.07	41.49	32	3580	13549	63471861
Restlessness	85.62	41.49	39	3573	29414	63455996
Labelled drug-drug interaction medication error	77.40	41.49	29	3583	13370	63472040
Dysarthria	71.87	41.49	39	3573	42672	63442738
Drug interaction	71.58	41.49	76	3536	229055	63256355
Rhonchi	68.78	41.49	18	3594	2558	63482852
Facial nerve disorder	65.00	41.49	13	3599	556	63484854
Electrocardiogram ST-T segment abnormal	53.40	41.49	10	3602	301	63485109
Suicide attempt	51.87	41.49	36	3576	60882	63424528
Hypotension	51.42	41.49	70	3542	272534	63212876
Cerebrospinal fluid retention	50.67	41.49	8	3604	84	63485326
Apathy	50.65	41.49	19	3593	8775	63476635
Tachypnoea	47.40	41.49	22	3590	17280	63468130
Brain contusion	47.10	41.49	10	3602	575	63484835
Depressed level of consciousness	44.40	41.49	33	3579	62045	63423365
Vascular encephalopathy	43.98	41.49	9	3603	432	63484978
Cerebral ventricular rupture	43.85	41.49	8	3604	208	63485202
Pallor	43.45	41.49	25	3587	30543	63454867
Coma	43.33	41.49	33	3579	64331	63421079
Subileus	42.78	41.49	13	3599	3166	63482244

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cerebral artery thrombosis	105.19	34.41	22	3040	758	34953111
Brain scan abnormal	102.54	34.41	22	3040	858	34953011
Areflexia	84.46	34.41	24	3038	3007	34950862
Product monitoring error	79.90	34.41	25	3037	4356	34949513
Pleurothotonus	74.66	34.41	18	3044	1187	34952682
General physical health deterioration	71.72	34.41	71	2991	128198	34825671
Wrong patient received product	64.96	34.41	19	3043	2635	34951234
Bradyarrhythmia	63.98	34.41	18	3044	2173	34951696
Fall	63.40	34.41	83	2979	202802	34751067
Neuroleptic malignant syndrome	60.19	34.41	30	3032	17904	34935965
Hemiplegia	50.45	34.41	20	3042	6952	34946917
Congenital cystic kidney disease	46.25	34.41	10	3052	404	34953465
Ischaemic stroke	45.43	34.41	25	3037	18225	34935644
Withdrawal syndrome	45.25	34.41	22	3040	12433	34941436
Facial paralysis	45.24	34.41	21	3041	10713	34943156
Drug withdrawal convulsions	45.21	34.41	12	3050	1165	34952704
Depressed level of consciousness	42.64	34.41	33	3029	42808	34911061
Wound	41.57	34.41	22	3040	14842	34939027
Restlessness	40.16	34.41	26	3036	25456	34928413
Renal aplasia	40.13	34.41	10	3052	756	34953113
Respiratory distress	38.85	34.41	29	3033	35636	34918233
Heart disease congenital	38.68	34.41	11	3051	1379	34952490
Conduction disorder	38.29	34.41	12	3050	2098	34951771
Hangover	36.99	34.41	10	3052	1041	34952828

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	229.22	36.26	182	6090	275056	79463060
Fall	157.51	36.26	192	6080	487437	79250679
Product prescribing error	134.16	36.26	67	6205	44746	79693370
Product monitoring error	110.58	36.26	37	6235	8869	79729247
Restlessness	106.20	36.26	58	6214	46434	79691682
Labelled drug-drug interaction medication error	99.78	36.26	47	6225	27603	79710513
Brain scan abnormal	92.24	36.26	21	6251	1202	79736914
Pleurothotonus	91.40	36.26	24	6248	2492	79735624
Drug interaction	90.10	36.26	135	6137	415048	79323068
Cerebral artery thrombosis	88.78	36.26	20	6252	1091	79737025
Depressed level of consciousness	84.52	36.26	66	6206	96586	79641530
Apathy	79.35	36.26	32	6240	12945	79725171
Hypothermia	76.97	36.26	37	6235	22709	79715407
Dysarthria	76.67	36.26	54	6218	67568	79670548
Areflexia	68.72	36.26	23	6249	5511	79732605
Wrong patient received product	68.68	36.26	22	6250	4596	79733520
Wound	66.08	36.26	62	6210	116117	79621999
Neuroleptic malignant syndrome	59.10	36.26	33	6239	27526	79710590
Facial nerve disorder	57.70	36.26	13	6259	709	79737407
Hypotension	56.96	36.26	114	6158	440203	79297913
Bradyarrhythmia	54.55	36.26	18	6254	4128	79733988
Rhonchi	51.01	36.26	17	6255	4019	79734097
Electrocardiogram QT prolonged	50.92	36.26	48	6224	90338	79647778
Coma	48.37	36.26	49	6223	100600	79637516
Wrong product administered	47.54	36.26	20	6252	8992	79729124
Tachycardia	47.54	36.26	64	6208	177704	79560412
Cerebrospinal fluid retention	47.10	36.26	8	6264	96	79738020
Myoclonus	45.77	36.26	28	6244	27632	79710484
Product administration error	44.59	36.26	29	6243	31817	79706299
Parkinsonism	44.35	36.26	23	6249	16561	79721555
Tachypnoea	41.98	36.26	28	6244	32035	79706081
Altered state of consciousness	40.60	36.26	31	6241	43791	79694325
Arrhythmia	39.29	36.26	35	6237	61237	79676879
Drug withdrawal convulsions	38.95	36.26	12	6260	2208	79735908
Subileus	38.24	36.26	15	6257	5639	79732477
Vascular encephalopathy	37.97	36.26	9	6263	614	79737502
Somnolence	37.14	36.26	67	6205	238914	79499202
Rabbit syndrome	37.12	36.26	8	6264	355	79737761

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05AD05	NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Butyrophenone derivatives
MeSH PA	D014150	Antipsychotic Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D018490	Serotonin Agents
MeSH PA	D012702	Serotonin Antagonists
MeSH PA	D014149	Tranquilizing Agents
CHEBI has role	CHEBI:48279	serotonin antagonists
CHEBI has role	CHEBI:48561	dopaminergic antagonists
CHEBI has role	CHEBI:65190	typical antipsychotic drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.93	Basic
pKa2	6.19	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source
Beta-1 adrenergic receptor	GPCR	P08588	ADRB1_HUMAN		Ki	5.30	PDSP
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN		Ki	5.30	PDSP
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	6.94	PDSP
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	6.07	PDSP
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN	ANTAGONIST	Ki	5.60	IUPHAR
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN	ANTAGONIST	Ki	8.30	IUPHAR
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	7.32	PDSP
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	6.64	PDSP
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	7.46	PDSP
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	6.60	PDSP
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN	ANTAGONIST	Ki	5.60	IUPHAR
5-hydroxytryptamine receptor 1B	GPCR	P28222	5HT1B_HUMAN	ANTAGONIST	Ki	6.20	IUPHAR
5-hydroxytryptamine receptor 1D	GPCR	P28221	5HT1D_HUMAN	ANTAGONIST	Ki	6.80	IUPHAR
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	6.54	PDSP
5-hydroxytryptamine receptor 1F	GPCR	P30939	5HT1F_HUMAN		Ki	5.30	PDSP
5-hydroxytryptamine receptor 1E	GPCR	P28566	5HT1E_HUMAN		Ki	5.30	PDSP

External reference:

ID	Source
D01482	KEGG_DRUG
C0071098	UMLSCUI
CHEBI:78549	CHEBI
CHEMBL440294	ChEMBL_ID
DB09286	DRUGBANK_ID
C005569	MESH_SUPPLEMENTAL_RECORD_UI
4830	PUBCHEM_CID
92	IUPHAR_LIGAND_ID
1588	INN_ID
2448-68-2	SECONDARY_CAS_RN
5402501F0W	UNII
289159	RXNORM
005709	NDDF
005710	NDDF
703362007	SNOMEDCT_US
703363002	SNOMEDCT_US
703364008	SNOMEDCT_US

Pharmaceutical products:

None