barbital 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
hypnotics, barbituric acid derivatives 289 57-44-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • barbital sodium
  • sodium diethylbarbiturate
  • barbital
  • barbitone
  • diethylbarbitone
  • diethylbarbituric acid
  • diethylmalonylurea
  • ethylbarbital
  • veronal
A long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice for central nervous system depression.
  • Molecular weight: 184.20
  • Formula: C8H12N2O3
  • CLOGP: 0.66
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 75.27
  • ALOGS: -1.76
  • ROTB: 2

Drug dosage:

DoseUnitRoute
0.50 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP3K21,MAPK7,PDK1,PDK2,PIK3CD,PRKDC,STK33,TEK 21
kinase-selectivity-class AXL,BRAF,CAMK2D,CDK9,GRK2,MAPK7,STK33,TEK 8
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05CA04 NERVOUS SYSTEM
PSYCHOLEPTICS
HYPNOTICS AND SEDATIVES
Barbiturates, plain
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
CHEBI has role CHEBI:35623 anticonvulsant

Related Drugs by ATC class:

N05CA Barbiturates, plain 17 drugs
allobarbitalamobarbitalaprobarbitalbutobarbitalcyclobarbitaletallobarbitalheptabarbhexobarbitalmethohexitalpentobarbitalproxibarbalreposal show all 17 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Insomnia indication 193462001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.31 acidic
pKa2 10.0 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019012 VUID
N0000147286 NUI
D01740 KEGG_DRUG
144-02-5 SECONDARY_CAS_RN
1325 RXNORM
C0004743 UMLSCUI
CHEBI:31252 CHEBI
CHEMBL444 ChEMBL_ID
DB01483 DRUGBANK_ID
CHEMBL2105904 ChEMBL_ID
D001462 MESH_DESCRIPTOR_UI
2294 PUBCHEM_CID
379 INN_ID
5WZ53ENE2P UNII
380 INN_ID
4007495 VANDF
4019012 VANDF
4019030 VANDF
001404 NDDF
001405 NDDF
111124009 SNOMEDCT_US

Pharmaceutical products:

None