Stem definition | Drug id | CAS RN |
---|---|---|
hypnotics, barbituric acid derivatives | 1748 | 151-83-7 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 100 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 7.62 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 1.10 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 12 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.27 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.60 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
June 27, 1960 | FDA | PAR STERILE PRODUCTS |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | N01AF01 | NERVOUS SYSTEM ANESTHETICS ANESTHETICS, GENERAL Barbiturates, plain |
ATC | N05CA15 | NERVOUS SYSTEM PSYCHOLEPTICS HYPNOTICS AND SEDATIVES Barbiturates, plain |
FDA CS | M0002177 | Barbiturates |
MeSH PA | D000777 | Anesthetics |
MeSH PA | D018686 | Anesthetics, Intravenous |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
CHEBI has role | CHEBI:38877 | intravenous anesthetics |
FDA EPC | N0000175693 | Barbiturate |
CHEBI has role | CHEBI:88188 | allergenic drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
General anesthesia | indication | 50697003 | |
Local anesthesia | indication | 386761002 | |
Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
Shock | contraindication | 27942005 | |
Low blood pressure | contraindication | 45007003 | |
Chronic heart failure | contraindication | 48447003 | |
Hepatic failure | contraindication | 59927004 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Seizure disorder | contraindication | 128613002 | |
Asthma | contraindication | 195967001 | DOID:2841 |
Morbid obesity | contraindication | 238136002 | DOID:11981 |
Anemia | contraindication | 271737000 | DOID:2355 |
Porphyria | contraindication | 418470004 | |
Hypertensive urgency | contraindication | 443482000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.3 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
GABA-A receptor alpha-1/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | WOMBAT-PK | CHEMBL | |||||
Glycine receptor subunit alpha-1 | Ion channel | WOMBAT-PK | |||||||
Neuronal acetylcholine receptor; alpha2/beta2 | Ion channel | WOMBAT-PK |
ID | Source |
---|---|
4019827 | VUID |
N0000147915 | NUI |
D00712 | KEGG_DRUG |
309-36-4 | SECONDARY_CAS_RN |
4017455 | VANDF |
4019827 | VANDF |
C0025668 | UMLSCUI |
CHEBI:102216 | CHEBI |
CHEMBL7413 | ChEMBL_ID |
DB00474 | DRUGBANK_ID |
CHEMBL30219 | ChEMBL_ID |
D008723 | MESH_DESCRIPTOR_UI |
9034 | PUBCHEM_CID |
7233 | IUPHAR_LIGAND_ID |
807 | INN_ID |
E5B8ND5IPE | UNII |
6847 | RXNORM |
184408 | MMSL |
3682 | MMSL |
5076 | MMSL |
d00929 | MMSL |
001400 | NDDF |
004580 | NDDF |
373488009 | SNOMEDCT_US |
39124003 | SNOMEDCT_US |
91594002 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Brevital Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42023-105 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAMUSCULAR | NDA | 26 sections |