pyridoxine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2836 65-23-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pyridoxine
  • adermin
  • bezatin
  • pirivitol
  • pyridoxin
  • pyridoxine hydrochloride
  • pyridoxine (vit B6)
  • vitamin b6
  • pyridoxine HCl
The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
  • Molecular weight: 169.18
  • Formula: C8H11NO3
  • CLOGP: -0.35
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 3
  • TPSA: 73.58
  • ALOGS: -1.02
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.16 g O
0.16 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 222 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 39.43 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.66 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.90 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.98 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1993 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 914.18 9.96 3732 325804 236483 46120043
Pemphigus 812.99 9.96 1277 328259 43997 46312529
Completed suicide 767.81 9.96 72 329464 145848 46210678
Systemic lupus erythematosus 688.76 9.96 1461 328075 63719 46292807
Glossodynia 542.70 9.96 1057 328479 43316 46313210
Toxicity to various agents 465.41 9.96 485 329051 211281 46145245
Maternal exposure during pregnancy 426.43 9.96 1640 327896 100909 46255617
Hand deformity 395.52 9.96 801 328735 33773 46322753
Alopecia 344.90 9.96 2142 327394 160272 46196254
Arthropathy 332.92 9.96 1331 328205 83369 46273157
Drug abuse 328.79 9.96 33 329503 63375 46293151
Abdominal discomfort 324.91 9.96 2000 327536 149165 46207361
Pain 286.19 9.96 4838 324698 472110 45884416
Death 284.98 9.96 1309 328227 334239 46022287
Joint swelling 283.40 9.96 2075 327461 163998 46192528
Infusion related reaction 278.30 9.96 1431 328105 99777 46256749
Intentional overdose 270.62 9.96 63 329473 64881 46291645
Exposure during pregnancy 268.90 9.96 1488 328048 106724 46249802
Arthralgia 259.52 9.96 3807 325729 360796 45995730
Wound 243.53 9.96 760 328776 42042 46314484
Drug interaction 235.48 9.96 696 328840 202398 46154128
Drug hypersensitivity 196.87 9.96 968 328568 242857 46113669
Synovitis 196.10 9.96 903 328633 60172 46296354
Overdose 188.34 9.96 267 329269 101712 46254814
Anti-cyclic citrullinated peptide antibody positive 187.01 9.96 416 329120 18729 46337797
Nasopharyngitis 185.12 9.96 1779 327757 152219 46204307
Contraindicated product administered 172.30 9.96 1059 328477 78888 46277638
Pericarditis 168.93 9.96 459 329077 23468 46333058
Rheumatoid factor positive 159.20 9.96 407 329129 20054 46336472
Swelling 158.89 9.96 1457 328079 123054 46233472
Cardiac arrest 158.80 9.96 245 329291 90154 46266372
Suicide attempt 157.01 9.96 97 329439 54939 46301587
Acute kidney injury 156.79 9.96 998 328538 234857 46121669
Hip arthroplasty 151.13 9.96 370 329166 17742 46338784
Febrile neutropenia 150.02 9.96 274 329262 94353 46262173
Product use issue 133.37 9.96 1132 328404 93512 46263014
Red blood cell sedimentation rate abnormal 131.53 9.96 295 329241 13354 46343172
Knee arthroplasty 130.71 9.96 416 329120 23249 46333277
Musculoskeletal stiffness 127.67 9.96 1152 328384 96841 46259685
Pregnancy 126.86 9.96 451 329085 26686 46329840
Injection site erythema 126.17 9.96 929 328607 73498 46283028
C-reactive protein abnormal 123.10 9.96 380 329156 20890 46335636
Sickle cell anaemia with crisis 117.47 9.96 143 329393 3849 46352677
Depressed level of consciousness 117.17 9.96 98 329438 47471 46309055
Discomfort 112.62 9.96 637 328899 46033 46310493
Device expulsion 106.53 9.96 31 329505 27511 46329015
Injection site pain 106.41 9.96 1191 328345 105961 46250565
Bradycardia 101.50 9.96 196 329340 66102 46290424
Lactic acidosis 97.78 9.96 59 329477 33850 46322676
Hyponatraemia 97.64 9.96 376 329160 100956 46255570
Cardiac failure 97.64 9.96 267 329269 79681 46276845
Injection site pruritus 97.58 9.96 545 328991 39198 46317328
Respiratory arrest 95.89 9.96 60 329476 33756 46322770
Cardio-respiratory arrest 90.78 9.96 178 329358 59691 46296835
Blood pressure fluctuation 89.55 9.96 439 329097 30009 46326517
Abortion spontaneous 88.28 9.96 569 328967 43077 46313449
Sopor 87.14 9.96 17 329519 19811 46336715
Malignant neoplasm progression 86.86 9.96 207 329329 64719 46291807
Injection site swelling 84.82 9.96 531 329005 39796 46316730
Arthritis 84.45 9.96 876 328660 76440 46280086
Injection site reaction 83.79 9.96 602 328934 47247 46309279
Psoriatic arthropathy 81.56 9.96 487 329049 35892 46320634
Osteoarthritis 80.14 9.96 728 328808 61297 46295229
Therapeutic product effect decreased 77.43 9.96 908 328628 81693 46274833
Drug reaction with eosinophilia and systemic symptoms 76.37 9.96 58 329478 29490 46327036
Product quality issue 73.34 9.96 86 329450 35562 46320964
Agitation 73.08 9.96 178 329358 55237 46301289
Intentional self-injury 72.59 9.96 40 329496 24126 46332400
Caesarean section 72.57 9.96 270 329266 16333 46340193
Rhabdomyolysis 72.21 9.96 115 329421 41794 46314732
Renal failure 71.64 9.96 488 329048 113106 46243420
Basal cell carcinoma 71.04 9.96 310 329226 20177 46336349
Disease progression 69.25 9.96 370 329166 90930 46265596
Confusional state 67.90 9.96 761 328775 159131 46197395
Duodenal ulcer perforation 67.04 9.96 170 329366 8332 46348194
Tuberculosis 64.68 9.96 189 329347 10076 46346450
Helicobacter infection 64.52 9.96 206 329330 11530 46344996
Fatigue 63.22 9.96 5049 324487 603648 45752878
Joint effusion 62.75 9.96 207 329329 11788 46344738
Sinusitis 62.17 9.96 1273 328263 128495 46228031
Premature delivery 61.92 9.96 314 329222 21755 46334771
Disability assessment scale score increased 60.93 9.96 77 329459 2155 46354371
Asthma 60.88 9.96 387 329149 91155 46265371
Dyspnoea 60.34 9.96 3000 326536 512548 45843978
Hypotension 59.79 9.96 1220 328316 231369 46125157
Electrocardiogram QT prolonged 58.55 9.96 177 329359 51148 46305378
Anxiety 58.28 9.96 918 328618 181039 46175487
Psoriasis 57.63 9.96 826 328710 77778 46278748
Neutropenia 56.75 9.96 692 328844 142512 46214014
Tremor 56.63 9.96 532 329004 115107 46241419
Tachycardia 55.14 9.96 444 329092 99178 46257348
Drug withdrawal syndrome 53.24 9.96 69 329467 27315 46329211
Joint laxity 52.05 9.96 69 329467 2027 46354499
Oropharyngeal pain 51.86 9.96 773 328763 73395 46283131
Pulmonary arterial hypertension 51.79 9.96 64 329472 25864 46330662
Drug dependence 51.51 9.96 39 329497 19862 46336664
Premature labour 51.28 9.96 186 329350 11113 46345413
Pre-eclampsia 51.15 9.96 148 329388 7846 46348680
Delirium 51.14 9.96 117 329419 37111 46319415
Cholestasis 51.02 9.96 69 329467 26824 46329702
Sedation 50.73 9.96 52 329484 22858 46333668
Impaired healing 50.40 9.96 437 329099 36306 46320220
Osteoporosis 50.11 9.96 472 329064 40136 46316390
Drug ineffective 49.83 9.96 5486 324050 672352 45684174
Injection site bruising 48.97 9.96 424 329112 35212 46321314
Localised infection 48.55 9.96 311 329225 23490 46333036
Live birth 48.54 9.96 172 329364 10158 46346368
Cytomegalovirus infection 47.68 9.96 35 329501 18109 46338417
Hepatocellular injury 47.18 9.96 85 329451 29437 46327089
Foetal exposure during pregnancy 47.15 9.96 375 329161 30372 46326154
Serotonin syndrome 47.11 9.96 61 329475 24159 46332367
Poisoning 46.84 9.96 20 329516 13974 46342552
Hypoglycaemia 45.94 9.96 212 329324 54137 46302389
Injection site rash 45.78 9.96 227 329309 15586 46340940
Treatment failure 45.16 9.96 915 328621 92172 46264354
Blood pressure diastolic abnormal 44.67 9.96 121 329415 6173 46350353
Gestational diabetes 44.61 9.96 132 329404 7087 46349439
Pain in extremity 44.23 9.96 2241 327295 256439 46100087
Maternal drugs affecting foetus 44.20 9.96 111 329425 5407 46351119
Shock 43.55 9.96 54 329482 21791 46334735
Hepatic function abnormal 43.48 9.96 113 329423 34308 46322218
Metabolic acidosis 43.33 9.96 135 329401 38645 46317881
Anaphylactic reaction 43.23 9.96 210 329326 52902 46303624
Neck deformity 42.94 9.96 59 329477 1795 46354731
Lower respiratory tract infection 42.43 9.96 584 328952 54505 46302021
Red blood cell sedimentation rate increased 42.41 9.96 292 329244 22597 46333929
Altered state of consciousness 42.21 9.96 62 329474 23286 46333240
Hepatic enzyme increased 42.05 9.96 811 328725 80976 46275550
Intentional product misuse 41.53 9.96 181 329355 46947 46309579
Hyperkalaemia 40.99 9.96 201 329335 50508 46306018
Coma 40.69 9.96 243 329293 58106 46298420
Hyperglycaemia 39.96 9.96 121 329415 34950 46321576
Rheumatoid nodule 39.68 9.96 147 329389 8873 46347653
Juvenile idiopathic arthritis 39.46 9.96 89 329447 4043 46352483
Influenza 39.25 9.96 865 328671 88405 46268121
Respiratory failure 39.15 9.96 454 329082 94362 46262164
Mydriasis 38.80 9.96 13 329523 10540 46345986
Herpes zoster 38.35 9.96 683 328853 67189 46289337
Hypothermia 38.31 9.96 19 329517 12164 46344362
Encephalopathy 38.19 9.96 116 329420 33473 46323053
Somnolence 38.12 9.96 828 328708 155693 46200833
Constipation 37.65 9.96 938 328598 173159 46183367
General physical health deterioration 37.40 9.96 583 328953 115186 46241340
Blood creatine phosphokinase increased 37.38 9.96 88 329448 27636 46328890
Blood pressure systolic abnormal 37.11 9.96 104 329432 5413 46351113
Urticaria 36.97 9.96 597 328939 117295 46239231
Infective pulmonary exacerbation of cystic fibrosis 36.89 9.96 15 329521 10792 46345734
Cardiac failure congestive 36.84 9.96 442 329094 91308 46265218
Foot deformity 36.84 9.96 210 329326 15215 46341311
Peripheral swelling 36.62 9.96 1413 328123 156658 46199868
Product use in unapproved indication 36.59 9.96 434 329102 89839 46266687
Nausea 36.58 9.96 4273 325263 683181 45673345
Diabetic ketoacidosis 36.32 9.96 45 329491 18165 46338361
Multiple organ dysfunction syndrome 36.24 9.96 215 329321 51495 46305031
Ejection fraction decreased 36.12 9.96 44 329492 17893 46338633
Vomiting 36.10 9.96 2730 326806 450064 45906462
Restlessness 36.05 9.96 79 329457 25445 46331081
Cerebral haemorrhage 35.94 9.96 93 329443 28278 46328248
Pulmonary embolism 35.69 9.96 545 328991 108040 46248486
Emotional distress 35.67 9.96 105 329431 30602 46325924
Pulmonary tuberculosis 35.65 9.96 93 329443 4638 46351888
Hallucination 35.37 9.96 207 329329 49744 46306782
Musculoskeletal pain 35.23 9.96 693 328843 69435 46287091
Femur fracture 35.22 9.96 408 329128 36589 46319937
Dizziness 35.16 9.96 2005 327531 338409 46018117
Syncope 35.14 9.96 524 329012 104279 46252247
Loss of personal independence in daily activities 35.04 9.96 583 328953 56600 46299926
Disorientation 34.89 9.96 138 329398 36780 46319746
Osteonecrosis of jaw 34.84 9.96 125 329411 34277 46322249
Nodule 34.39 9.96 208 329328 15397 46341129
Renal impairment 34.35 9.96 347 329189 74025 46282501
No adverse event 34.26 9.96 125 329411 34106 46322420
Disseminated intravascular coagulation 33.84 9.96 51 329485 18954 46337572
Drug resistance 33.52 9.96 44 329492 17324 46339202
Hypoxia 33.51 9.96 221 329315 51617 46304909
Multiple sclerosis relapse 33.45 9.96 168 329368 41957 46314569
Hyperhidrosis 33.33 9.96 437 329099 88871 46267655
Myocardial infarction 32.91 9.96 487 329049 97041 46259485
Angioedema 32.34 9.96 155 329381 39187 46317339
Ventricular septal defect 32.16 9.96 81 329455 3953 46352573
Hepatic failure 32.16 9.96 124 329412 33292 46323234
Bone erosion 32.06 9.96 142 329394 9301 46347225
Limb deformity 31.92 9.96 75 329461 3501 46353025
Ventricular tachycardia 31.71 9.96 44 329492 16923 46339603
Therapeutic response decreased 31.46 9.96 453 329083 42692 46313834
Torsade de pointes 31.22 9.96 24 329512 12130 46344396
Small for dates baby 31.08 9.96 75 329461 3562 46352964
Heart rate decreased 30.72 9.96 351 329185 31372 46325154
Posterior reversible encephalopathy syndrome 30.63 9.96 37 329499 15104 46341422
Disturbance in attention 30.44 9.96 117 329419 31443 46325083
Insomnia 30.36 9.96 909 328627 164015 46192511
Gastroenteritis viral 30.01 9.96 225 329311 17894 46338632
Malignant melanoma 29.69 9.96 147 329389 10087 46346439
Gestational hypertension 29.63 9.96 54 329482 2101 46354425
Myalgia 29.42 9.96 653 328883 122435 46234091
Bronchitis 29.38 9.96 967 328569 105012 46251514
Latent tuberculosis 29.37 9.96 51 329485 1909 46354617
Injection site warmth 29.36 9.96 182 329354 13590 46342936
Neck mass 29.32 9.96 69 329467 3224 46353302
Extrapyramidal disorder 29.27 9.96 22 329514 11246 46345280
Arthritis infective 29.26 9.96 91 329445 5022 46351504
Blood pressure diastolic decreased 28.56 9.96 185 329351 14026 46342500
Developmental hip dysplasia 28.48 9.96 40 329496 1243 46355283
Respiratory depression 28.43 9.96 24 329512 11576 46344950
Smear cervix abnormal 28.41 9.96 58 329478 2458 46354068
Abnormal behaviour 28.26 9.96 67 329469 20991 46335535
Haemoglobin decreased 28.06 9.96 1145 328391 127804 46228722
Inappropriate antidiuretic hormone secretion 27.96 9.96 35 329501 14067 46342459
Weight increased 27.88 9.96 1424 328112 163049 46193477
Neoplasm progression 27.66 9.96 96 329440 26587 46329939
Premature rupture of membranes 27.45 9.96 81 329455 4342 46352184
Oral herpes 27.32 9.96 232 329304 19158 46337368
Accidental overdose 26.81 9.96 64 329472 20002 46336524
Blood pressure systolic increased 26.75 9.96 316 329220 28471 46328055
Ventricular fibrillation 26.72 9.96 25 329511 11471 46345055
Enthesopathy 26.40 9.96 83 329453 4607 46351919
Unresponsive to stimuli 26.30 9.96 127 329409 32047 46324479
Anaphylactic shock 26.04 9.96 66 329470 20208 46336318
Febrile bone marrow aplasia 26.03 9.96 8 329528 6854 46349672
Grip strength decreased 25.95 9.96 125 329411 8481 46348045
Multiple fractures 25.56 9.96 92 329444 5475 46351051
Fibromyalgia 25.46 9.96 380 329156 36083 46320443
Blood pressure diastolic increased 25.15 9.96 96 329440 5878 46350648
Wheezing 25.10 9.96 248 329288 53138 46303388
Speech disorder 25.01 9.96 151 329385 36016 46320510
Metastases to liver 24.96 9.96 64 329472 19521 46337005
Joint stiffness 24.94 9.96 297 329239 26811 46329715
Joint destruction 24.93 9.96 62 329474 3002 46353524
Postoperative wound infection 24.87 9.96 125 329411 8628 46347898
Synovial cyst 24.59 9.96 110 329426 7236 46349290
Asthenia 24.50 9.96 1877 327659 309198 46047328
Mental status changes 24.30 9.96 163 329373 37925 46318601
Hypokalaemia 24.30 9.96 456 329080 87568 46268958
Neutrophil count decreased 24.26 9.96 193 329343 43233 46313293
Surgery 24.17 9.96 310 329226 28475 46328051
Loss of consciousness 23.96 9.96 581 328955 107657 46248869
Condition aggravated 23.70 9.96 2023 327513 243029 46113497
Seizure 23.69 9.96 674 328862 122380 46234146
Skin papilloma 23.59 9.96 74 329462 4102 46352424
Foetal death 23.55 9.96 123 329413 8620 46347906
Cellulitis 23.40 9.96 656 328880 69632 46286894
Skin ulcer 23.34 9.96 340 329196 32118 46324408
Tenosynovitis stenosans 23.29 9.96 46 329490 1903 46354623
Swollen joint count increased 23.26 9.96 52 329484 2348 46354178
Product administration error 23.07 9.96 67 329469 19614 46336912
Dyspnoea exertional 23.07 9.96 235 329301 50054 46306472
Squamous cell carcinoma 23.05 9.96 113 329423 7723 46348803
Psychotic disorder 23.04 9.96 82 329454 22539 46333987
Skin cancer 23.00 9.96 123 329413 8700 46347826
Drug level increased 22.94 9.96 61 329475 18380 46338146
Suicidal ideation 22.86 9.96 271 329265 56111 46300415
Rheumatic fever 22.58 9.96 57 329479 2786 46353740
Blood pressure increased 22.56 9.96 1102 328434 125564 46230962
Polyhydramnios 22.47 9.96 46 329490 1953 46354573
Acute generalised exanthematous pustulosis 22.39 9.96 20 329516 9385 46347141
International normalised ratio increased 22.37 9.96 217 329319 46666 46309860
Atrioventricular block complete 22.37 9.96 13 329523 7614 46348912
Metastases to bone 22.36 9.96 57 329479 17419 46339107
Arrhythmia 22.28 9.96 149 329387 34692 46321834
Agranulocytosis 22.21 9.96 81 329455 22104 46334422
Respiratory distress 22.20 9.96 133 329403 31783 46324743
Fluid retention 22.01 9.96 242 329294 50804 46305722
Tenderness 21.72 9.96 198 329338 16683 46339843
Aspartate aminotransferase increased 21.63 9.96 408 329128 78292 46278234
Cyst 21.61 9.96 153 329383 11947 46344579
Placental disorder 21.56 9.96 37 329499 1372 46355154
Erythema multiforme 21.51 9.96 22 329514 9682 46346844
Thrombocytopenia 21.50 9.96 705 328831 125876 46230650
Melaena 21.35 9.96 112 329424 27660 46328866
Contusion 21.18 9.96 786 328750 86701 46269825
Fracture 21.09 9.96 193 329343 16278 46340248
Decreased appetite 21.01 9.96 1136 328400 192700 46163826
Eye infection 21.00 9.96 123 329413 9000 46347526
Transplant rejection 21.00 9.96 22 329514 9574 46346952
Foot fracture 20.95 9.96 221 329315 19361 46337165
Orthostatic hypotension 20.94 9.96 96 329440 24562 46331964
Inflammation 20.90 9.96 471 329065 48310 46308216
Hypermethioninaemia 20.82 9.96 7 329529 12 46356514
Alanine aminotransferase increased 20.63 9.96 471 329065 87980 46268546
Stress cardiomyopathy 20.47 9.96 15 329521 7769 46348757
Acute hepatic failure 20.43 9.96 46 329490 14675 46341851
Chest discomfort 20.41 9.96 483 329053 89786 46266740
Dry eye 20.39 9.96 314 329222 30008 46326518
Coagulopathy 20.24 9.96 65 329471 18434 46338092
Complication of device insertion 20.18 9.96 5 329531 4939 46351587
Immunodeficiency 20.17 9.96 160 329376 12946 46343580
Leukopenia 20.13 9.96 350 329186 67993 46288533
Rash 20.12 9.96 2840 326696 353672 46002854
Akathisia 20.11 9.96 15 329521 7699 46348827
Mouth ulceration 20.06 9.96 283 329253 26549 46329977
Clear cell renal cell carcinoma 20.04 9.96 30 329506 989 46355537
Brain oedema 19.87 9.96 36 329500 12442 46344084
Immunosuppression 19.85 9.96 105 329431 7395 46349131
Atrial septal defect 19.84 9.96 93 329443 6239 46350287
Face oedema 19.79 9.96 69 329467 19084 46337442
Deep vein thrombosis 19.69 9.96 421 329115 79352 46277174
Device dislocation 19.65 9.96 83 329453 21719 46334807
Drug intolerance 19.65 9.96 1246 328290 145803 46210723
Vitamin B6 increased 19.65 9.96 6 329530 6 46356520
Synovial fluid analysis 19.53 9.96 35 329501 1344 46355182
Diabetes mellitus inadequate control 19.41 9.96 40 329496 13174 46343352
Acute chest syndrome 19.40 9.96 22 329514 548 46355978
Respiratory disorder 19.40 9.96 113 329423 27187 46329339
Thrombotic microangiopathy 19.38 9.96 18 329518 8288 46348238
Blood glucose increased 19.27 9.96 375 329161 71638 46284888
Off label use 19.19 9.96 2368 327168 377473 45979053
Laryngitis 19.16 9.96 122 329414 9194 46347332
Serum ferritin increased 19.13 9.96 81 329455 5202 46351324
Blood alkaline phosphatase increased 19.04 9.96 183 329353 39426 46317100
Acute myeloid leukaemia 19.02 9.96 53 329483 15725 46340801
Hallucination, auditory 19.02 9.96 29 329507 10727 46345799
Injection site urticaria 18.92 9.96 147 329389 11820 46344706
Antinuclear antibody positive 18.78 9.96 91 329445 6189 46350337
Bronchospasm 18.76 9.96 53 329483 15654 46340872
Blood pressure decreased 18.73 9.96 287 329249 56872 46299654
Pulmonary hypertension 18.73 9.96 163 329373 35830 46320696
Acute graft versus host disease 18.70 9.96 3 329533 4027 46352499
Gamma-glutamyltransferase increased 18.70 9.96 139 329397 31601 46324925
Eosinophilia 18.69 9.96 71 329465 19146 46337380
Bone disorder 18.66 9.96 220 329316 19813 46336713
Blood bilirubin increased 18.60 9.96 153 329383 34031 46322495
Breast feeding 18.58 9.96 27 329509 866 46355660
Dysarthria 18.56 9.96 172 329364 37326 46319200
Hospitalisation 18.55 9.96 325 329211 63060 46293466
Disability 18.42 9.96 129 329407 10038 46346488
Nightmare 18.39 9.96 58 329478 16540 46339986
Schizophrenia 18.35 9.96 20 329516 8548 46347978
Graft versus host disease 18.25 9.96 12 329524 6576 46349950
Maternal exposure before pregnancy 18.04 9.96 71 329465 4410 46352116
Oedema 18.03 9.96 349 329187 66722 46289804
Body height below normal 18.00 9.96 40 329496 1799 46354727
Plasma cell myeloma 17.95 9.96 214 329322 44264 46312262
Joint injury 17.91 9.96 211 329325 18998 46337528
Aggression 17.89 9.96 91 329445 22653 46333873
Blood iron increased 17.86 9.96 33 329503 1298 46355228
Loose body in joint 17.85 9.96 29 329507 1027 46355499
Tooth infection 17.84 9.96 148 329388 12138 46344388
Cervical incompetence 17.82 9.96 22 329514 601 46355925
Neuroleptic malignant syndrome 17.79 9.96 32 329504 11090 46345436
Joint range of motion decreased 17.77 9.96 174 329362 14950 46341576
Pancreatitis acute 17.64 9.96 103 329433 24769 46331757
Polyarthritis 17.60 9.96 92 329444 6450 46350076
Congenital arterial malformation 17.57 9.96 17 329519 350 46356176
Mania 17.54 9.96 31 329505 10815 46345711
Chronic kidney disease 17.52 9.96 194 329342 40677 46315849
Carpal tunnel syndrome 17.45 9.96 180 329356 15679 46340847
Ischaemic stroke 17.44 9.96 60 329476 16662 46339864
Substance abuse 17.43 9.96 4 329532 4163 46352363
Injury 17.32 9.96 213 329323 43814 46312712
Miosis 17.29 9.96 13 329523 6644 46349882
Maternal exposure during breast feeding 17.24 9.96 51 329485 2738 46353788
Asphyxia 17.22 9.96 8 329528 5318 46351208
Knee operation 17.20 9.96 73 329463 4693 46351833
Injection site haematoma 17.17 9.96 87 329449 6025 46350501
Exomphalos 17.00 9.96 20 329516 519 46356007
Cholecystitis chronic 16.98 9.96 30 329506 10469 46346057
Viral infection 16.98 9.96 304 329232 29931 46326595
Pharyngitis streptococcal 16.87 9.96 110 329426 8358 46348168
Synovial disorder 16.86 9.96 25 329511 817 46355709
Pancytopenia 16.85 9.96 748 328788 84310 46272216
Device difficult to use 16.79 9.96 19 329517 7985 46348541
Disseminated tuberculosis 16.70 9.96 50 329486 2702 46353824
Jaundice 16.67 9.96 127 329409 28718 46327808
Poor venous access 16.60 9.96 108 329428 8200 46348326
Stillbirth 16.58 9.96 90 329446 6401 46350125
Wheelchair user 16.54 9.96 64 329472 3944 46352582
Weight decreased 16.53 9.96 1715 327821 209134 46147392
Rotator cuff repair 16.46 9.96 34 329502 1453 46355073
Rash maculo-papular 16.45 9.96 122 329414 27752 46328774
Bradyphrenia 16.39 9.96 12 329524 6218 46350308
Cytokine release syndrome 16.36 9.96 12 329524 6211 46350315
Cystitis 16.30 9.96 402 329134 41839 46314687
Anhedonia 16.30 9.96 30 329506 10305 46346221
Induced labour 16.27 9.96 26 329510 908 46355618
Rhinorrhoea 16.18 9.96 446 329090 47219 46309307
Haemorrhage 16.16 9.96 281 329255 54588 46301938
Toxic skin eruption 16.16 9.96 40 329496 12347 46344179
Ketoacidosis 16.15 9.96 4 329532 3951 46352575
Pain in jaw 16.11 9.96 183 329353 38189 46318337
Spinal stenosis 16.07 9.96 147 329389 12396 46344130
Bone density abnormal 15.93 9.96 53 329483 3031 46353495
Device use error 15.86 9.96 8 329528 5073 46351453
Blood creatinine increased 15.86 9.96 414 329122 75989 46280537
Joint noise 15.78 9.96 54 329482 3133 46353393
Depression 15.72 9.96 1012 328524 169092 46187434
Injection site haemorrhage 15.72 9.96 219 329317 20490 46336036
Second primary malignancy 15.68 9.96 14 329522 6570 46349956
Dehydration 15.64 9.96 944 328592 158596 46197930
Fear 15.57 9.96 60 329476 16112 46340414
Tooth disorder 15.55 9.96 241 329295 23062 46333464
Pathogen resistance 15.52 9.96 12 329524 6048 46350478
Foetal distress syndrome 15.49 9.96 30 329506 1223 46355303
Pulmonary fibrosis 15.46 9.96 213 329323 19879 46336647
Cognitive disorder 15.45 9.96 176 329360 36707 46319819
Diverticulitis 15.43 9.96 323 329213 32716 46323810
Tumour lysis syndrome 15.38 9.96 17 329519 7219 46349307
Tachypnoea 15.30 9.96 51 329485 14300 46342226
Ascites 15.15 9.96 175 329361 36409 46320117
Neurotoxicity 15.15 9.96 48 329488 13669 46342857
Hypomania 15.13 9.96 6 329530 4382 46352144
Scleritis 15.00 9.96 50 329486 2862 46353664
Hypersensitivity 14.99 9.96 1244 328292 149077 46207449
Diarrhoea 14.98 9.96 3613 325923 555989 45800537
Arthritis bacterial 14.97 9.96 80 329456 5656 46350870
Injection site irritation 14.96 9.96 65 329471 4222 46352304
Muscle spasticity 14.88 9.96 37 329499 11403 46345123
Naevus flammeus 14.80 9.96 10 329526 120 46356406
Renal injury 14.77 9.96 28 329508 9513 46347013
Antibody test positive 14.75 9.96 41 329495 2124 46354402
Morning sickness 14.65 9.96 21 329515 665 46355861
Limb injury 14.65 9.96 203 329333 18971 46337555
Pulmonary oedema 14.64 9.96 263 329273 50842 46305684
Post procedural infection 14.61 9.96 97 329439 7416 46349110
Vertigo 14.55 9.96 269 329267 51779 46304747
Fracture delayed union 14.55 9.96 41 329495 2141 46354385
Shock haemorrhagic 14.54 9.96 24 329512 8600 46347926
Human antichimeric antibody positive 14.39 9.96 31 329505 1365 46355161
Cardiogenic shock 14.39 9.96 63 329473 16321 46340205
Cerebrovascular accident 14.38 9.96 575 328961 100464 46256062
Sedation complication 14.28 9.96 4 329532 3641 46352885
Palpitations 14.23 9.96 539 328997 94720 46261806
Ear infection 14.23 9.96 235 329301 22778 46333748
Talipes 14.22 9.96 31 329505 1376 46355150
Stevens-Johnson syndrome 14.22 9.96 101 329435 23196 46333330
Tubulointerstitial nephritis 14.15 9.96 55 329481 14733 46341793
Cushingoid 14.11 9.96 84 329452 6182 46350344
Cholestasis of pregnancy 14.00 9.96 27 329509 1097 46355429
Haematotoxicity 13.96 9.96 17 329519 6916 46349610
Premature baby 13.93 9.96 192 329344 17920 46338606
Bursitis 13.93 9.96 207 329329 19635 46336891
Joint lock 13.89 9.96 39 329497 2032 46354494
Hyperuricaemia 13.89 9.96 8 329528 4709 46351817
Carcinoma in situ of skin 13.81 9.96 12 329524 214 46356312
Myopathy 13.81 9.96 26 329510 8855 46347671
Arthropod sting 13.79 9.96 23 329513 833 46355693
Complication associated with device 13.79 9.96 59 329477 15382 46341144
Aspergillus infection 13.77 9.96 17 329519 6873 46349653
Upper respiratory tract infection 13.73 9.96 564 328972 62992 46293534
Crying 13.72 9.96 90 329446 21051 46335475
Cartilage injury 13.72 9.96 33 329503 1564 46354962
Haemorrhage intracranial 13.72 9.96 45 329491 12679 46343847
Frequent bowel movements 13.72 9.96 143 329393 12489 46344037
Transplant dysfunction 13.70 9.96 8 329528 4674 46351852
Pemphigoid 13.67 9.96 12 329524 5679 46350847
Lip swelling 13.66 9.96 114 329422 25281 46331245
Pancreatitis 13.64 9.96 221 329315 43406 46313120
Lung neoplasm 13.61 9.96 78 329458 5662 46350864
Pyrexia 13.57 9.96 2209 327327 346593 46009933
Catheter site pain 13.46 9.96 5 329531 3801 46352725
Delivery 13.41 9.96 20 329516 657 46355869
Polyneuropathy 13.39 9.96 40 329496 11604 46344922
Pleural effusion 13.38 9.96 465 329071 82487 46274039
Haemophagocytic lymphohistiocytosis 13.35 9.96 24 329512 8318 46348208
Genital haemorrhage 13.33 9.96 16 329520 6550 46349976
Fluid overload 13.32 9.96 125 329411 27060 46329466
Oliguria 13.31 9.96 26 329510 8733 46347793
Haemorrhage in pregnancy 13.30 9.96 33 329503 1595 46354931
Colitis microscopic 13.29 9.96 16 329520 6540 46349986
Hiatus hernia 13.27 9.96 192 329344 18110 46338416
Atrial fibrillation 13.17 9.96 597 328939 102993 46253533
Medication error 13.14 9.96 147 329389 30764 46325762
Gastroenteritis 13.07 9.96 242 329294 23977 46332549
Lymphadenectomy 13.02 9.96 23 329513 873 46355653
Cerebral infarction 12.98 9.96 104 329432 23262 46333264
Feeling abnormal 12.97 9.96 736 328800 124324 46232202
Dactylitis 12.88 9.96 27 329509 1166 46355360
Lupus-like syndrome 12.76 9.96 97 329439 7747 46348779
Hallucination, visual 12.69 9.96 74 329462 17799 46338727
Cytomegalovirus viraemia 12.62 9.96 8 329528 4470 46352056
Lymph node tuberculosis 12.58 9.96 21 329515 761 46355765
Ingrown hair 12.55 9.96 16 329520 452 46356074
Cyanosis 12.50 9.96 64 329472 15907 46340619
Sickle cell anaemia 12.47 9.96 18 329518 574 46355952
Haematocrit decreased 12.46 9.96 330 329206 34727 46321799
Acidosis 12.41 9.96 39 329497 11135 46345391
Atrioventricular block 12.39 9.96 18 329518 6793 46349733
Body temperature decreased 12.37 9.96 147 329389 13262 46343264
Dysgeusia 12.36 9.96 206 329330 40285 46316241
Vision blurred 12.35 9.96 449 329087 79259 46277267
Joint dislocation 12.32 9.96 127 329409 11059 46345467
Uterine contractions during pregnancy 12.28 9.96 17 329519 521 46356005
Cardiac failure acute 12.25 9.96 24 329512 8054 46348472
Sinus congestion 12.22 9.96 144 329392 12965 46343561
Skin laceration 12.21 9.96 191 329345 18311 46338215
Infusion site pain 12.15 9.96 34 329502 10073 46346453
Circulatory collapse 12.12 9.96 96 329440 21528 46334998
Myoclonus 12.11 9.96 56 329480 14296 46342230
Accidental exposure to product 12.10 9.96 93 329443 20988 46335538
Wrong technique in product usage process 12.07 9.96 292 329244 54130 46302396
Tinea pedis 11.93 9.96 29 329507 1384 46355142
VIth nerve disorder 11.88 9.96 3 329533 0 46356526
CSF oligoclonal band 11.88 9.96 3 329533 0 46356526
Withdrawal syndrome 11.87 9.96 77 329459 18057 46338469
Hypomagnesaemia 11.81 9.96 100 329436 22110 46334416
Tardive dyskinesia 11.80 9.96 22 329514 7521 46349005
Joint warmth 11.78 9.96 27 329509 1240 46355286
Delusion 11.77 9.96 40 329496 11148 46345378
Anaemia 11.74 9.96 1604 327932 254175 46102351
Anterior chamber cleavage syndrome 11.71 9.96 10 329526 174 46356352
Breech presentation 11.69 9.96 25 329511 1095 46355431
Intervertebral disc degeneration 11.67 9.96 144 329392 13108 46343418
Injection site extravasation 11.66 9.96 85 329451 6700 46349826
Chest pain 11.58 9.96 1079 328457 175245 46181281
Diabetes mellitus 11.55 9.96 267 329269 49798 46306728
Incorrect route of product administration 11.54 9.96 68 329468 16315 46340211
Tonsillitis 11.47 9.96 67 329469 4897 46351629
Catheter site erythema 11.38 9.96 7 329529 3976 46352550
Infusion site erythema 11.34 9.96 23 329513 7619 46348907
Meningitis tuberculous 11.32 9.96 17 329519 562 46355964
Foetal anticonvulsant syndrome 11.31 9.96 15 329521 441 46356085
Forceps delivery 11.30 9.96 10 329526 183 46356343
Autism spectrum disorder 11.25 9.96 17 329519 565 46355961
Product adhesion issue 11.25 9.96 11 329525 4944 46351582
Complication of pregnancy 11.25 9.96 16 329520 503 46356023
Labelled drug-drug interaction medication error 11.25 9.96 30 329506 9031 46347495
Postpartum haemorrhage 11.24 9.96 33 329503 1764 46354762
Failed induction of labour 11.21 9.96 13 329523 332 46356194
Tenosynovitis 11.16 9.96 91 329445 7424 46349102
Pancreatic steatosis 11.15 9.96 23 329513 982 46355544
C-reactive protein increased 11.11 9.96 513 329023 58077 46298449
Hypoglycaemia neonatal 11.04 9.96 22 329514 916 46355610
Injection site induration 11.03 9.96 96 329440 7983 46348543
Trichophytosis 11.02 9.96 6 329530 47 46356479
Intestinal stenosis 11.02 9.96 41 329495 2480 46354046
Red blood cell count decreased 11.00 9.96 305 329231 32318 46324208
Human anti-human antibody test 11.00 9.96 13 329523 339 46356187
Cold type haemolytic anaemia 10.99 9.96 10 329526 190 46356336
Creatinine renal clearance decreased 10.99 9.96 20 329516 6900 46349626
Pulmonary alveolar haemorrhage 10.97 9.96 8 329528 4154 46352372
Vacuum extractor delivery 10.96 9.96 9 329527 148 46356378
Abortion missed 10.94 9.96 30 329506 1542 46354984
Obstructive airways disorder 10.93 9.96 53 329483 13359 46343167
Placental insufficiency 10.90 9.96 27 329509 1304 46355222
Parkinsonism 10.90 9.96 25 329511 7923 46348603
Multiple sclerosis 10.90 9.96 117 329419 24674 46331852
Coronary artery disease 10.88 9.96 170 329366 33582 46322944
Mycobacterium tuberculosis complex test positive 10.86 9.96 30 329506 1548 46354978
Preterm premature rupture of membranes 10.84 9.96 23 329513 1002 46355524
Upper respiratory tract irritation 10.82 9.96 6 329530 49 46356477
Cardiomyopathy 10.65 9.96 68 329468 16005 46340521
Gastrointestinal haemorrhage 10.65 9.96 442 329094 76931 46279595
Polychondritis 10.65 9.96 14 329522 408 46356118
Tendon disorder 10.64 9.96 66 329470 4929 46351597
Anuria 10.63 9.96 43 329493 11388 46345138
Lymphoma 10.61 9.96 111 329425 9702 46346824
Metastases to central nervous system 10.56 9.96 42 329494 11179 46345347
Red blood cell sedimentation rate 10.56 9.96 32 329504 1741 46354785
Endodontic procedure 10.52 9.96 40 329496 2445 46354081
Crystal nephropathy 10.50 9.96 20 329516 805 46355721
Lymphatic fistula 10.49 9.96 21 329515 877 46355649
Nail injury 10.46 9.96 14 329522 415 46356111
Mass 10.42 9.96 127 329409 11526 46345000
Abortion incomplete 10.40 9.96 5 329531 3259 46353267
Animal bite 10.39 9.96 38 329498 2279 46354247
Platelet count increased 10.38 9.96 155 329381 14719 46341807
Disease recurrence 10.36 9.96 82 329454 18389 46338137
Wound infection pseudomonas 10.35 9.96 28 329508 1427 46355099
Dysphagia 10.35 9.96 443 329093 76869 46279657
Product complaint 10.34 9.96 47 329489 12054 46344472
Photophobia 10.32 9.96 152 329384 14392 46342134
Femoral hernia incarcerated 10.32 9.96 21 329515 888 46355638
Aortic embolus 10.29 9.96 5 329531 30 46356496
Hypervitaminosis 10.29 9.96 5 329531 30 46356496
Pulseless electrical activity 10.27 9.96 22 329514 7145 46349381
Dyskinesia 10.25 9.96 143 329393 28782 46327744
Pleuritic pain 10.25 9.96 79 329457 6337 46350189
Hypophosphataemia 10.24 9.96 23 329513 7344 46349182
Muscle rupture 10.24 9.96 35 329501 2030 46354496
Drug abuser 10.23 9.96 5 329531 3228 46353298
Normal newborn 10.21 9.96 75 329461 5926 46350600
Cytopenia 10.20 9.96 25 329511 7743 46348783
Ulcer 10.17 9.96 176 329360 17216 46339310
Tooth abscess 10.16 9.96 135 329401 12498 46344028
Aphonia 10.12 9.96 93 329443 7852 46348674
Hyperprolactinaemia 10.12 9.96 4 329532 2928 46353598
Bite 10.09 9.96 13 329523 371 46356155
Drug ineffective for unapproved indication 10.09 9.96 71 329465 16342 46340184
Neonatal respiratory distress syndrome 10.09 9.96 40 329496 2493 46354033
Bone contusion 10.08 9.96 20 329516 830 46355696
Inflammatory bowel disease 9.99 9.96 47 329489 3158 46353368
Angina pectoris 9.99 9.96 131 329405 26644 46329882
Oedema peripheral 9.97 9.96 981 328555 158725 46197801
Stress at work 9.96 9.96 22 329514 985 46355541

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 380.86 10.19 712 148185 40485 29763096
Drug abuse 331.23 10.19 19 148878 82053 29721528
Completed suicide 243.39 10.19 95 148802 99397 29704184
Toxicity to various agents 231.81 10.19 326 148571 176857 29626724
Foetal exposure during pregnancy 189.44 10.19 504 148393 36367 29767214
Arthralgia 181.68 10.19 1226 147671 134565 29669016
Psoriatic arthropathy 101.56 10.19 235 148662 15526 29788055
Drug interaction 98.65 10.19 585 148312 198983 29604598
Sickle cell anaemia with crisis 89.89 10.19 83 148814 2319 29801262
Premature baby 84.50 10.19 227 148670 16464 29787117
Joint swelling 80.33 10.19 452 148445 46494 29757087
Intentional overdose 72.21 10.19 60 148837 41421 29762160
Overdose 70.64 10.19 201 148696 84136 29719445
Exposure during pregnancy 69.74 10.19 147 148750 9114 29794467
Neonatal respiratory distress syndrome 67.09 10.19 91 148806 3921 29799660
Nasopharyngitis 63.95 10.19 506 148391 58343 29745238
Enthesopathy 62.99 10.19 75 148822 2831 29800750
Atrial septal defect 60.82 10.19 115 148782 6586 29796995
Tenosynovitis 60.72 10.19 81 148816 3434 29800147
Acute kidney injury 59.39 10.19 981 147916 272861 29530720
Tuberculosis 57.13 10.19 125 148772 7952 29795629
Blood pressure fluctuation 54.35 10.19 201 148696 17302 29786279
Death 52.58 10.19 1364 147533 355919 29447662
Maternal drugs affecting foetus 51.37 10.19 83 148814 4190 29799391
Hypospadias 51.37 10.19 65 148832 2614 29800967
Musculoskeletal stiffness 50.86 10.19 329 148568 35552 29768029
Drug reaction with eosinophilia and systemic symptoms 48.60 10.19 42 148855 28446 29775135
Haemoglobin decreased 48.56 10.19 817 148080 113281 29690300
Low birth weight baby 46.39 10.19 97 148800 5979 29797602
Hepatic function abnormal 45.52 10.19 87 148810 41858 29761723
Small for dates baby 43.70 10.19 66 148831 3142 29800439
Maternal exposure during breast feeding 43.68 10.19 47 148850 1585 29801996
Maternal exposure during pregnancy 43.58 10.19 73 148824 3798 29799783
Respiratory arrest 43.17 10.19 49 148848 29209 29774372
Suicide attempt 42.61 10.19 73 148824 36624 29766957
Febrile neutropenia 42.52 10.19 333 148564 106360 29697221
Rhabdomyolysis 41.97 10.19 168 148729 63412 29740169
Synovitis 40.72 10.19 124 148773 9659 29793922
Intentional product misuse 40.21 10.19 69 148828 34598 29768983
Hypoglycaemia neonatal 39.61 10.19 44 148853 1539 29802042
Dysmorphism 38.77 10.19 49 148848 1968 29801613
Tongue disorder 37.78 10.19 73 148824 4249 29799332
Ventricular septal defect 37.68 10.19 65 148832 3464 29800117
Product use in unapproved indication 36.84 10.19 215 148682 73478 29730103
Cardiac arrest 35.97 10.19 292 148605 92558 29711023
Cryptorchism 35.88 10.19 43 148854 1634 29801947
Coma 35.64 10.19 94 148803 40355 29763226
Pain 35.29 10.19 1115 147782 171526 29632055
Cardiac failure 35.29 10.19 256 148641 83162 29720419
Drug withdrawal syndrome 35.28 10.19 28 148869 19781 29783800
Serotonin syndrome 34.85 10.19 23 148874 17868 29785713
Infusion related reaction 34.25 10.19 330 148567 40234 29763347
Arthritis 34.12 10.19 223 148674 24178 29779403
Pancytopenia 33.63 10.19 602 148295 84450 29719131
Psoriasis 33.56 10.19 341 148556 42165 29761416
C-reactive protein abnormal 33.43 10.19 81 148816 5512 29798069
Angioedema 33.36 10.19 76 148821 34308 29769273
Syndactyly 32.58 10.19 28 148869 710 29802871
Basal cell carcinoma 32.45 10.19 162 148735 15906 29787675
Peripheral swelling 32.36 10.19 454 148443 60620 29742961
Drug dependence 32.14 10.19 35 148862 21260 29782321
Lower respiratory tract infection 31.96 10.19 235 148662 26479 29777102
Blood pressure systolic increased 31.70 10.19 154 148743 14956 29788625
Arthropathy 31.19 10.19 193 148704 20534 29783047
Poisoning 31.04 10.19 9 148888 11373 29792208
Pulmonary fibrosis 30.55 10.19 158 148739 15732 29787849
Large for dates baby 30.51 10.19 29 148868 841 29802740
Drug intolerance 30.06 10.19 351 148546 44940 29758641
Exposure via breast milk 29.92 10.19 38 148859 1534 29802047
Delirium 29.65 10.19 103 148794 40528 29763053
Bradycardia 28.73 10.19 199 148698 65327 29738254
Drug resistance 28.33 10.19 35 148862 20098 29783483
Osteoarthritis 27.70 10.19 171 148726 18178 29785403
Foetal anticonvulsant syndrome 27.53 10.19 26 148871 748 29802833
Loss of personal independence in daily activities 27.24 10.19 192 148705 21343 29782238
Cytomegalovirus infection 26.66 10.19 48 148849 23626 29779955
Alanine aminotransferase abnormal 26.36 10.19 47 148850 2572 29801009
Renal failure 25.91 10.19 468 148429 128498 29675083
Pulmonary tuberculosis 25.53 10.19 67 148830 4790 29798791
Shock 25.16 10.19 47 148850 22812 29780769
Musculoskeletal pain 24.80 10.19 249 148648 30691 29772890
Hyperglycaemia 24.51 10.19 91 148806 35109 29768472
Weight decreased 24.40 10.19 949 147948 149972 29653609
Skin cancer 24.36 10.19 91 148806 7870 29795711
Agitation 24.30 10.19 163 148734 53910 29749671
Blood pressure systolic abnormal 23.42 10.19 33 148864 1474 29802107
Congenital hand malformation 23.30 10.19 19 148878 447 29803134
Pain in extremity 23.05 10.19 714 148183 109507 29694074
Medical device implantation 23.01 10.19 20 148877 515 29803066
Hypoglycaemia 22.75 10.19 154 148743 50827 29752754
Juvenile idiopathic arthritis 22.74 10.19 27 148870 1016 29802565
Pathogen resistance 22.30 10.19 7 148890 8403 29795178
Renal impairment 22.18 10.19 290 148607 83894 29719687
Knee arthroplasty 22.17 10.19 70 148827 5560 29798021
Body temperature decreased 22.15 10.19 101 148796 9554 29794027
Selective eating disorder 22.03 10.19 34 148863 1650 29801931
Rheumatoid nodule 21.94 10.19 34 148863 1656 29801925
Intentional self-injury 21.83 10.19 21 148876 13511 29790070
Tendonitis 21.46 10.19 88 148809 7948 29795633
Suicidal ideation 21.03 10.19 100 148797 36014 29767567
Arthritis bacterial 20.89 10.19 59 148838 4405 29799176
Bradycardia neonatal 20.45 10.19 24 148873 892 29802689
Substance abuse 20.27 10.19 5 148892 7035 29796546
Serum ferritin increased 19.96 10.19 66 148831 5371 29798210
Aggression 19.89 10.19 105 148792 36802 29766779
Agitation neonatal 19.86 10.19 25 148872 1000 29802581
Blood pressure increased 19.86 10.19 483 148414 71445 29732136
Caesarean section 19.80 10.19 37 148860 2100 29801481
Hepatic cyst 19.66 10.19 40 148857 2418 29801163
Blood creatine phosphokinase increased 19.29 10.19 133 148764 43715 29759866
Neuroleptic malignant syndrome 19.29 10.19 32 148865 16263 29787318
Injection site pain 19.27 10.19 233 148664 30077 29773504
Somnolence 19.15 10.19 352 148545 96411 29707170
Pneumonia 19.02 10.19 1918 146979 332388 29471193
Red blood cell count decreased 18.82 10.19 207 148690 26114 29777467
Appendicolith 18.75 10.19 23 148874 896 29802685
Jaundice neonatal 18.52 10.19 25 148872 1072 29802509
Low set ears 18.51 10.19 16 148881 409 29803172
Foetal growth restriction 18.38 10.19 49 148848 3536 29800045
Anal atresia 18.20 10.19 14 148883 302 29803279
Infective pulmonary exacerbation of cystic fibrosis 18.12 10.19 10 148887 8562 29795019
Talipes 18.08 10.19 31 148866 1644 29801937
Hand deformity 18.07 10.19 33 148864 1840 29801741
Neck mass 18.02 10.19 28 148869 1367 29802214
Back disorder 17.91 10.19 68 148829 5926 29797655
Asthma 17.82 10.19 106 148791 36068 29767513
Depressed level of consciousness 17.79 10.19 114 148783 38108 29765473
Back pain 17.73 10.19 650 148247 101946 29701635
Cellulitis 17.72 10.19 329 148568 46455 29757126
Neuropathy peripheral 17.61 10.19 467 148430 70008 29733573
Lacrimal disorder 17.58 10.19 14 148883 318 29803263
Cleft lip 17.55 10.19 14 148883 319 29803262
Haemangioma congenital 17.44 10.19 17 148880 509 29803072
Vitamin D deficiency 17.43 10.19 61 148836 5109 29798472
Multiple organ dysfunction syndrome 17.35 10.19 217 148680 63270 29740311
Tachycardia 17.30 10.19 260 148637 73479 29730102
Post procedural infection 17.23 10.19 56 148841 4516 29799065
Infection 17.18 10.19 509 148388 77565 29726016
Toxic optic neuropathy 17.14 10.19 19 148878 663 29802918
Speech disorder developmental 17.13 10.19 25 148872 1154 29802427
Hyperbilirubinaemia neonatal 16.96 10.19 19 148878 671 29802910
Venoocclusive liver disease 16.67 10.19 6 148891 6607 29796974
Incorrect route of product administration 16.63 10.19 19 148878 11296 29792285
Prostate cancer 16.48 10.19 187 148710 23770 29779811
Congenital bladder anomaly 16.41 10.19 13 148884 293 29803288
Influenza 16.37 10.19 305 148592 43093 29760488
Rash maculo-papular 16.24 10.19 68 148829 25350 29778231
Microphthalmos 16.19 10.19 11 148886 194 29803387
Poor venous access 15.99 10.19 37 148860 2443 29801138
Umbilical hernia 15.79 10.19 47 148850 3614 29799967
Joint effusion 15.78 10.19 47 148850 3616 29799965
Haematocrit decreased 15.76 10.19 227 148670 30472 29773109
Off label use 15.71 10.19 1048 147849 248242 29555339
Immunodeficiency 15.65 10.19 52 148845 4242 29799339
Altered state of consciousness 15.56 10.19 49 148848 19870 29783711
Injection site bruising 15.54 10.19 75 148822 7263 29796318
Fatigue 15.47 10.19 1820 147077 318853 29484728
Weight decrease neonatal 15.31 10.19 13 148884 324 29803257
Accessory spleen 15.24 10.19 10 148887 166 29803415
Otitis media 15.11 10.19 37 148860 2534 29801047
Agranulocytosis 15.09 10.19 57 148840 21885 29781696
Patent ductus arteriosus 14.94 10.19 42 148855 3127 29800454
Ankyloglossia congenital 14.87 10.19 12 148885 278 29803303
Arthrodesis 14.64 10.19 14 148883 409 29803172
Blood pressure diastolic increased 14.45 10.19 38 148859 2720 29800861
Hypermobility syndrome 14.39 10.19 11 148886 235 29803346
Full blood count decreased 14.33 10.19 130 148767 15587 29787994
Foetal disorder 14.29 10.19 17 148880 641 29802940
Cytokine release syndrome 14.26 10.19 17 148880 9916 29793665
Hypotension 14.21 10.19 834 148063 199731 29603850
Multiple congenital abnormalities 14.18 10.19 15 148882 496 29803085
Blood pressure diastolic decreased 14.16 10.19 65 148832 6166 29797415
Disease progression 14.15 10.19 296 148601 79578 29724003
Product quality issue 14.09 10.19 47 148850 18727 29784854
Peripheral artery thrombosis 14.07 10.19 33 148864 2199 29801382
Intellectual disability 14 10.19 19 148878 819 29802762
Pancreatic calcification 13.94 10.19 10 148887 193 29803388
Drug withdrawal syndrome neonatal 13.93 10.19 41 148856 3134 29800447
Renal aplasia 13.88 10.19 17 148880 661 29802920
Developmental delay 13.87 10.19 32 148865 2109 29801472
Sinusitis 13.87 10.19 238 148659 33107 29770474
Cerebral haemorrhage 13.86 10.19 101 148796 32786 29770795
Akathisia 13.83 10.19 6 148891 5898 29797683
Urinary tract infection 13.79 10.19 471 148426 73188 29730393
Tremor neonatal 13.73 10.19 13 148884 375 29803206
Hypertriglyceridaemia 13.73 10.19 12 148885 8086 29795495
Septic arthritis staphylococcal 13.73 10.19 14 148883 443 29803138
Tonsil cancer 13.73 10.19 18 148879 750 29802831
Blood iron increased 13.72 10.19 19 148878 835 29802746
Osteonecrosis of jaw 13.71 10.19 47 148850 18571 29785010
Sedation 13.71 10.19 39 148858 16334 29787247
Wound 13.65 10.19 107 148790 12295 29791286
Upper respiratory tract infection 13.65 10.19 202 148695 27274 29776307
Restlessness 13.50 10.19 62 148835 22537 29781044
Anal fistula 13.41 10.19 47 148850 3939 29799642
Pleural fibrosis 13.38 10.19 25 148872 1419 29802162
Injection site swelling 13.36 10.19 82 148815 8698 29794883
Joint range of motion decreased 13.30 10.19 61 148836 5784 29797797
Hepatic failure 13.19 10.19 107 148790 33936 29769645
Neonatal seizure 13.16 10.19 14 148883 466 29803115
Finger deformity 12.94 10.19 20 148877 972 29802609
Arthritis infective 12.93 10.19 36 148861 2666 29800915
Foot deformity 12.86 10.19 42 148855 3395 29800186
Crohn's disease 12.70 10.19 49 148848 4303 29799278
Foetal heart rate deceleration abnormality 12.66 10.19 13 148884 415 29803166
Knee deformity 12.65 10.19 12 148885 347 29803234
Hydrocele 12.64 10.19 30 148867 2014 29801567
Vascular insufficiency 12.60 10.19 12 148885 349 29803232
Emphysema 12.58 10.19 85 148812 9317 29794264
Pyelocaliectasis 12.56 10.19 20 148877 997 29802584
Skin lesion 12.56 10.19 144 148753 18350 29785231
Disseminated intravascular coagulation 12.55 10.19 62 148835 22109 29781472
Grip strength decreased 12.53 10.19 31 148866 2137 29801444
Hernia pain 12.53 10.19 10 148887 228 29803353
Maternal exposure timing unspecified 12.51 10.19 12 148885 352 29803229
Moaning 12.43 10.19 17 148880 738 29802843
Latent tuberculosis 12.40 10.19 19 148878 916 29802665
Injection site erythema 12.40 10.19 114 148783 13720 29789861
Congenital anomaly 12.39 10.19 23 148874 1299 29802282
Progressive multifocal leukoencephalopathy 12.33 10.19 16 148881 8997 29794584
Heart rate decreased 12.32 10.19 159 148738 20835 29782746
Urticaria 12.30 10.19 194 148703 54412 29749169
Maternal exposure before pregnancy 12.29 10.19 12 148885 360 29803221
Malignant neoplasm progression 12.19 10.19 270 148627 72017 29731564
Injection site rash 12.14 10.19 42 148855 3497 29800084
Kidney infection 12.12 10.19 50 148847 4528 29799053
Nerve compression 12.11 10.19 36 148861 2766 29800815
Blood insulin increased 12.08 10.19 12 148885 368 29803213
Diverticular perforation 12.05 10.19 39 148858 3138 29800443
Palmar-plantar erythrodysaesthesia syndrome 12.02 10.19 36 148861 14834 29788747
Neutrophil count decreased 12.01 10.19 144 148753 42310 29761271
Mouth ulceration 11.94 10.19 92 148805 10517 29793064
Blood albumin decreased 11.91 10.19 105 148792 12487 29791094
Hepatic enzyme increased 11.81 10.19 233 148664 33261 29770320
Malignant melanoma 11.78 10.19 70 148827 7341 29796240
Vitamin B12 deficiency 11.77 10.19 34 148863 2571 29801010
Ventricular tachycardia 11.71 10.19 70 148827 23792 29779789
Anti-erythropoietin antibody positive 11.64 10.19 18 148879 875 29802706
Palindromic rheumatism 11.62 10.19 9 148888 196 29803385
Joint stiffness 11.57 10.19 83 148814 9278 29794303
Spinal disorder 11.46 10.19 40 148857 3345 29800236
Plagiocephaly 11.46 10.19 11 148886 323 29803258
Hypocalcaemia 11.41 10.19 61 148836 21315 29782266
Excessive cerumen production 11.36 10.19 10 148887 262 29803319
Folate deficiency 11.32 10.19 19 148878 990 29802591
Fistula 11.32 10.19 53 148844 5069 29798512
Gangrene neonatal 11.28 10.19 9 148888 205 29803376
Frequent bowel movements 11.25 10.19 76 148821 8329 29795252
Aspergillus infection 11.24 10.19 21 148876 10193 29793388
Contraindicated product administered 11.18 10.19 133 148764 17098 29786483
Non-Hodgkin's lymphoma 11.16 10.19 26 148871 1725 29801856
Pouchitis 11.13 10.19 15 148882 642 29802939
Hypoxia 11.12 10.19 169 148728 47685 29755896
Autism spectrum disorder 11.12 10.19 22 148875 1303 29802278
Medication error 11.11 10.19 60 148837 20912 29782669
Erythema multiforme 11.11 10.19 14 148883 7971 29795610
Nephrolithiasis 11.02 10.19 179 148718 24631 29778950
Cystitis haemorrhagic 11.00 10.19 5 148892 4782 29798799
Mean cell volume increased 10.98 10.19 29 148868 2081 29801500
Hepatitis fulminant 10.96 10.19 3 148894 3938 29799643
Allergy to arthropod bite 10.86 10.19 3 148894 3 29803578
Dairy intolerance 10.86 10.19 3 148894 3 29803578
Metastases to thyroid 10.86 10.19 3 148894 3 29803578
Hypermethioninaemia 10.86 10.19 3 148894 3 29803578
Congenital diaphragmatic hernia 10.85 10.19 9 148888 217 29803364
Acute graft versus host disease 10.81 10.19 8 148889 5856 29797725
Lactic acidosis 10.81 10.19 101 148796 31112 29772469
Acute hepatic failure 10.79 10.19 27 148870 11800 29791781
Subdural haematoma 10.77 10.19 53 148844 18919 29784662
Pulmonary artery stenosis congenital 10.73 10.19 13 148884 500 29803081
Unresponsive to stimuli 10.72 10.19 82 148815 26337 29777244
Blood lactic acid increased 10.69 10.19 8 148889 5822 29797759
C-reactive protein decreased 10.68 10.19 24 148873 1554 29802027
Interstitial lung disease 10.68 10.19 223 148674 59974 29743607
Gastrointestinal infection 10.67 10.19 42 148855 3723 29799858
Oedema 10.63 10.19 150 148747 42843 29760738
Stevens-Johnson syndrome 10.58 10.19 48 148849 17508 29786073
Pyrexia 10.49 10.19 1293 147604 293196 29510385
Cleft palate 10.49 10.19 14 148883 594 29802987
Blood pressure diastolic abnormal 10.36 10.19 21 148876 1266 29802315
Lung neoplasm malignant 10.36 10.19 118 148779 15014 29788567
Oesophageal adenocarcinoma 10.35 10.19 17 148880 870 29802711
Foetal hypokinesia 10.34 10.19 11 148886 366 29803215
Steatorrhoea 10.30 10.19 15 148882 691 29802890
Decreased vibratory sense 10.27 10.19 11 148886 369 29803212
Toxic epidermal necrolysis 10.25 10.19 50 148847 17890 29785691
Foetal distress syndrome 10.25 10.19 18 148879 973 29802608
Anaemia vitamin B12 deficiency 10.24 10.19 10 148887 300 29803281

Pharmacologic Action:

SourceCodeDescription
ATC A11HA02 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
ATC J04AM08 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Combinations of drugs for treatment of tuberculosis
FDA Chemical/Ingredient N0000005657 Vitamin B 6
FDA Chemical/Ingredient N0000175452 Analogs/Derivatives
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:75771 mus musculus metabolite
CHEBI has role CHEBI:75772 baker's yeast metabolite
CHEBI has role CHEBI:76971 e.coli metabolites
CHEBI has role CHEBI:77746 h. sapiens metabolites
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
FDA EPC N0000192800 Vitamin B6 Analog
CHEBI has role CHEBI:75769 vitamin b

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pregnancy, function indication 289908002
Vitamin B6 deficiency indication 386080007 DOID:8455
Breastfeeding (mother) indication 413712001
Drug-Induced Pyridoxine Deficiency indication
Pyridoxine-Dependent Seizure indication
Nutritional disorder contraindication 2492009 DOID:374
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Hyperkalemia contraindication 14140009
Gastroenteritis contraindication 25374005 DOID:2326
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Acute hepatitis contraindication 37871000
Hemosiderosis contraindication 39011001 DOID:12119
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Gastrectomy contraindication 53442002
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Schizophrenia contraindication 58214004 DOID:5419
Acute nephropathy contraindication 58574008
Leber's optic atrophy contraindication 58610003 DOID:705
Metabolic acidosis contraindication 59455009
Hepatic failure contraindication 59927004
Hemolytic anemia contraindication 61261009 DOID:583
Diarrhea contraindication 62315008
Ulcerative colitis contraindication 64766004 DOID:8577
Poisoning by acetaminophen contraindication 70273001
Diabetes mellitus contraindication 73211009 DOID:9351
Gastrointestinal hemorrhage contraindication 74474003
Atrophic gastritis contraindication 84568007 DOID:8929
Autoimmune disease contraindication 85828009
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Gastrointestinal obstruction contraindication 126765001
Acute hepatic failure contraindication 197270009
Impaired renal function disorder contraindication 197663003
Gastroparesis contraindication 235675006
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Esophageal dysmotility contraindication 266434009 DOID:9192
Diabetic - poor control contraindication 268519009
Peripheral nerve disease contraindication 302226006
Primary adrenocortical insufficiency contraindication 373662000
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Ketoacidosis in diabetes mellitus contraindication 420422005 DOID:1837
Diabetic peripheral neuropathy contraindication 424736006
Slow acetylator due to N-acetyltransferase enzyme variant contraindication 425079005
Chronic Hepatic Disease contraindication
Genitourinary Tract Infections contraindication
Repeated Blood Transfusions contraindication
Prolonged-Severe Nausea and Vomiting contraindication
Esophageal Compression contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.98 acidic
pKa2 13.8 acidic
pKa3 4.94 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Phosphoserine aminotransferase Enzyme WOMBAT-PK
Cystathionine beta-synthase Enzyme WOMBAT-PK
Pyridoxal kinase Kinase WOMBAT-PK
Pyridoxal phosphate phosphatase Enzyme WOMBAT-PK
Pyridoxine-5'-phosphate oxidase Enzyme WOMBAT-PK
Serine hydroxymethyltransferase, cytosolic Enzyme WOMBAT-PK

External reference:

IDSource
4019922 VUID
N0000148007 NUI
D02179 KEGG_DRUG
58-56-0 SECONDARY_CAS_RN
4017489 VANDF
4017779 VANDF
4018569 VANDF
4019922 VANDF
4021899 VANDF
C0034272 UMLSCUI
CHEBI:16709 CHEBI
UEG PDB_CHEM_ID
1054 PUBCHEM_CID
CHEMBL1364 ChEMBL_ID
CHEMBL1200756 ChEMBL_ID
D011736 MESH_DESCRIPTOR_UI
DB00165 DRUGBANK_ID
2216 INN_ID
KV2JZ1BI6Z UNII
203164 RXNORM
35074 MMSL
4979 MMSL
4994 MMSL
5393 MMSL
5686 MMSL
6601 MMSL
d00412 MMSL
001058 NDDF
004538 NDDF
126227009 SNOMEDCT_US
430469009 SNOMEDCT_US
767286000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 10 mg ORAL Unapproved drug other 12 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 25 mg ORAL unapproved drug other 10 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 25 mg ORAL UNULLPPROVED DRUG OTHER 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 25 mg ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 25 mg ORAL Unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 20 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 20 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 20 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 20 mg ORAL Unapproved drug other 9 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 12.50 mg ORAL unapproved drug other 10 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 20 mg ORAL Unapproved drug other 11 sections
Doxylamine Succinate and Pyridoxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0378-4615 TABLET, DELAYED RELEASE 10 mg ORAL ANDA 26 sections
Doxylamine succinate and pyridoxine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0591-2132 TABLET, DELAYED RELEASE 10 mg ORAL ANDA 25 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 2.50 mg ORAL unapproved drug other 7 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 15 mg ORAL UNULLPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 2.50 mg ORAL UNULLPPROVED DRUG OTHER 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 2.50 mg ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 2.50 mg ORAL UNULLPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 2.50 mg ORAL UNULLPPROVED DRUG OTHER 13 sections
Vitafol Nano HUMAN PRESCRIPTION DRUG LABEL 7 0642-0094 TABLET, COATED 2.50 mg ORAL UNULLPPROVED DRUG OTHER 14 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 2.50 mg ORAL UNULLPPROVED DRUG OTHER 13 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 25 mg ORAL UNULLPPROVED DRUG OTHER 15 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 25 mg ORAL UNULLPPROVED DRUG OTHER 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 2.50 mg ORAL unapproved drug other 7 sections
Vitafol HUMAN PRESCRIPTION DRUG LABEL 4 0642-7468 STRIP 2.50 mg ORAL Unapproved drug other 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 2.50 mg ORAL UNULLPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 5 mg ORAL UNULLPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 25 mg ORAL UNULLPPROVED DRUG OTHER 10 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 12 mg ORAL UNULLPPROVED DRUG OTHER 6 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 25 mg ORAL Unapproved drug other 7 sections