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trolnitrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| NO2 - derivatives | 2770 | 7077-34-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
synonym Angitrit refers to phosphate; structure #412; RN given refers to parent cpd
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 20 | mg | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FGFR1,FLT3,GRK2,GSK3B,IGF1R,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK1,MAPK10,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ZAP70 | 66 | |||
| kinase-selectivity-class | AURKB,AXL,BRAF,CAMK2D,CDK1,CDK16,CDK4,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,GSK3B,IRAK1,IRAK3,JAK2,MAP2K6,MAP3K21,MAPK1,MAPK7,MARK4,MET,MTOR,PDK4,PRKDC,SIK2,STK33,SYK,TEK,TTK,UHMK1,ULK1 | 33 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C01DA09 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY VASODILATORS USED IN CARDIAC DISEASES Organic nitrates |
| ATC | C01DA59 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY VASODILATORS USED IN CARDIAC DISEASES Organic nitrates |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
Related Drugs by ATC class:
C01DA Organic nitrates 7 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Vascular headache | off-label use | 128187005 | |
| Fibromyalgia | off-label use | 203082005 | DOID:631 |
| Heart valve disorder | contraindication | 368009 | DOID:4079 |
| Necrotizing enterocolitis in fetus OR newborn | contraindication | 2707005 | |
| Delirium | contraindication | 2776000 | |
| Ocular hypertension | contraindication | 4210003 | DOID:9282 |
| Gastritis | contraindication | 4556007 | DOID:4029 |
| Hypophosphatemia | contraindication | 4996001 | |
| Gilles de la Tourette's syndrome | contraindication | 5158005 | DOID:11119 |
| Tachyarrhythmia | contraindication | 6285003 | |
| Suicidal thoughts | contraindication | 6471006 | |
| Dependent drug abuse | contraindication | 6525002 | |
| Alcoholism | contraindication | 7200002 | |
| Alcohol withdrawal delirium | contraindication | 8635005 | |
| Hyperammonemia | contraindication | 9360008 | |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
| Bipolar disorder | contraindication | 13746004 | DOID:3312 |
| Asthenia | contraindication | 13791008 | |
| Hepatic encephalopathy | contraindication | 13920009 | DOID:13413 |
| Hyperkalemia | contraindication | 14140009 | |
| Constipation | contraindication | 14760008 | DOID:2089 |
| Chronic disease of respiratory system | contraindication | 17097001 | |
| Mood swings | contraindication | 18963009 | |
| Lowered convulsive threshold | contraindication | 19260006 | |
| Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
| Ataxia | contraindication | 20262006 | |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Glaucoma | contraindication | 23986001 | DOID:1686 |
| Feeling agitated | contraindication | 24199005 | |
| Inflammatory bowel disease | contraindication | 24526004 | DOID:0050589 |
| Ventricular tachycardia | contraindication | 25569003 | |
| Alcohol intoxication | contraindication | 25702006 | |
| Complete atrioventricular block | contraindication | 27885002 | |
| Shock | contraindication | 27942005 | |
| Hypovolemia | contraindication | 28560003 | |
| Orthostatic hypotension | contraindication | 28651003 | |
| Acute cerebrovascular insufficiency | contraindication | 29322000 | |
| Hypercapnia | contraindication | 29596007 | |
| Sarcoidosis | contraindication | 31541009 | DOID:11335 |
| Dehydration | contraindication | 34095006 | |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Depressive disorder | contraindication | 35489007 | |
| Acute hepatitis | contraindication | 37871000 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
| Gastrointestinal ulcer | contraindication | 40845000 | |
| Hypothyroidism | contraindication | 40930008 | DOID:1459 |
| Myxedema | contraindication | 43153006 | DOID:11634 |
| Body fluid retention | contraindication | 43498006 | |
| Hyperactive behavior | contraindication | 44548000 | |
| Fecal impaction | contraindication | 44635007 | |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Low blood pressure | contraindication | 45007003 | |
| Achalasia of esophagus | contraindication | 45564002 | DOID:9164 |
| Chronic heart failure | contraindication | 48447003 | |
| Bradycardia | contraindication | 48867003 | |
| Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
| Acidosis | contraindication | 51387008 | |
| Vitamin K deficiency | contraindication | 52675005 | DOID:11249 |
| Nasal polyp | contraindication | 52756005 | |
| Coronary arteriosclerosis | contraindication | 53741008 | DOID:3393 |
| Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
| Paralytic ileus | contraindication | 55525008 | DOID:8442 |
| Anorexia nervosa | contraindication | 56882008 | DOID:8689 |
| Congenital myotonia, autosomal dominant form | contraindication | 57938005 | |
| Schizophrenia | contraindication | 58214004 | DOID:5419 |
| Acute nephropathy | contraindication | 58574008 | |
| Hepatic failure | contraindication | 59927004 | |
| Aggressive behavior | contraindication | 61372001 | |
| Diarrhea | contraindication | 62315008 | |
| Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Poisoning by phenobarbital | contraindication | 64921004 | |
| Arterial thrombosis | contraindication | 65198009 | |
| Drug AND/OR toxin-induced diarrhea | contraindication | 65979008 | |
| Substance abuse | contraindication | 66214007 | |
| Hypercalcemia | contraindication | 66931009 | DOID:12678 |
| Hypermagnesemia | contraindication | 66978005 | |
| Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
| Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
| Psychotic disorder | contraindication | 69322001 | |
| Hemorrhoids | contraindication | 70153002 | DOID:9746 |
| Poisoning by acetaminophen | contraindication | 70273001 | |
| Agoraphobia | contraindication | 70691001 | DOID:593 |
| Pulmonary hypertension | contraindication | 70995007 | DOID:6432 |
| Arteriosclerotic vascular disease | contraindication | 72092001 | |
| Hepatic coma | contraindication | 72836002 | DOID:12550 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Sleep apnea | contraindication | 73430006 | DOID:0050847 |
| Factor II deficiency | contraindication | 73975000 | |
| Reye's syndrome | contraindication | 74351001 | DOID:14525 |
| Gastrointestinal hemorrhage | contraindication | 74474003 | |
| Urethral stricture | contraindication | 76618002 | |
| Thrombotic thrombocytopenic purpura | contraindication | 78129009 | DOID:10772 |
| Decreased respiratory function | contraindication | 80954004 | |
| Injury of head | contraindication | 82271004 | |
| Chronic idiopathic constipation | contraindication | 82934008 | |
| Cor pulmonale | contraindication | 83291003 | DOID:8515 |
| Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
| Epilepsy | contraindication | 84757009 | DOID:1826 |
| Leukopenia | contraindication | 84828003 | DOID:615 |
| Autoimmune disease | contraindication | 85828009 | |
| Cardiomyopathy | contraindication | 85898001 | DOID:0050700 |
| Pulmonary emphysema | contraindication | 87433001 | |
| Weight loss | contraindication | 89362005 | |
| Gout | contraindication | 90560007 | DOID:13189 |
| Chronic renal failure syndrome | contraindication | 90688005 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Thyrotoxicosis | contraindication | 90739004 | DOID:7997 |
| Hemophilia | contraindication | 90935002 | |
| Myasthenia gravis | contraindication | 91637004 | DOID:437 |
| Obstruction of duodenum | contraindication | 95532008 | DOID:3558 |
| Kidney stone | contraindication | 95570007 | |
| Disorder of biliary tract | contraindication | 105997008 | DOID:9741 |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Prolonged QT interval | contraindication | 111975006 | |
| Acute abdominal pain | contraindication | 116290004 | |
| Procedure on urinary system | contraindication | 118677009 | |
| Gastrointestinal obstruction | contraindication | 126765001 | |
| Neoplasm of brain | contraindication | 126952004 | DOID:1319 |
| Hb SS disease | contraindication | 127040003 | DOID:10923 |
| von Willebrand disorder | contraindication | 128105004 | DOID:12531 |
| Infectious disease of central nervous system | contraindication | 128117002 | |
| Acute disease of cardiovascular system | contraindication | 128487001 | |
| Structural disorder of heart | contraindication | 128599005 | |
| Seizure disorder | contraindication | 128613002 | |
| Prolonged PR interval | contraindication | 164947007 | |
| Liver function tests abnormal | contraindication | 166603001 | |
| Alcohol withdrawal syndrome | contraindication | 191480000 | |
| Drug-induced psychosis | contraindication | 191483003 | DOID:1742 |
| Obsessive-compulsive disorder | contraindication | 191736004 | DOID:10933 |
| Angina pectoris | contraindication | 194828000 | |
| Partial atrioventricular block | contraindication | 195039008 | |
| Decompensated cardiac failure | contraindication | 195111005 | |
| Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
| Impaired renal function disorder | contraindication | 197663003 | |
| Osteolysis | contraindication | 203522001 | |
| Motor tic disorder | contraindication | 230337001 | |
| Cerebrovascular accident | contraindication | 230690007 | |
| Mania | contraindication | 231494001 | |
| Gastroesophageal reflux disease | contraindication | 235595009 | DOID:8534 |
| Gastroparesis | contraindication | 235675006 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Drug-induced hepatitis | contraindication | 235876009 | |
| Chronic diarrhea | contraindication | 236071009 | |
| Hyporeninemic hypoaldosteronism | contraindication | 236464008 | |
| Aluminum intoxication | contraindication | 236546003 | |
| Bladder outflow obstruction | contraindication | 236645006 | |
| Morbid obesity | contraindication | 238136002 | DOID:11981 |
| Poisoning by opiate analgesic drug | contraindication | 241749009 | |
| Pyloric obstruction | contraindication | 244815007 | |
| Sleep automatism | contraindication | 247962006 | |
| Benign prostatic hyperplasia | contraindication | 266569009 | |
| Dyspnea | contraindication | 267036007 | |
| Retention of urine | contraindication | 267064002 | |
| Suicidal | contraindication | 267073005 | |
| Raised intracranial pressure | contraindication | 271719001 | DOID:9428 |
| Anemia | contraindication | 271737000 | DOID:2355 |
| Cerebral trauma | contraindication | 275382005 | |
| Exacerbation of asthma | contraindication | 281239006 | |
| Pregnancy, function | contraindication | 289908002 | |
| Lesion of brain | contraindication | 301766008 | |
| Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
| Peripheral nerve disease | contraindication | 302226006 | |
| Pheochromocytoma | contraindication | 302835009 | |
| Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
| Familial hyperkalemic periodic paralysis | contraindication | 304737009 | DOID:14451 |
| Bone marrow depression | contraindication | 307762000 | |
| Drug withdrawal | contraindication | 363101005 | |
| Serotonin syndrome | contraindication | 371089000 | |
| Panic disorder | contraindication | 371631005 | DOID:594 |
| Coma | contraindication | 371632003 | |
| Primary adrenocortical insufficiency | contraindication | 373662000 | |
| Operation on gastrointestinal tract | contraindication | 386621005 | |
| Impaired cognition | contraindication | 386806002 | |
| Hypoxia | contraindication | 389086002 | |
| Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
| Cardiovascular event risk | contraindication | 395112001 | |
| Visual impairment | contraindication | 397540003 | |
| Pseudomembranous enterocolitis | contraindication | 397683000 | |
| Vertigo | contraindication | 399153001 | |
| Peripheral vascular disease | contraindication | 400047006 | |
| Respiratory insufficiency | contraindication | 409623005 | |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Chronic myocardial ischemia | contraindication | 413844008 | DOID:3393 |
| Disorder of coronary artery | contraindication | 414024009 | |
| Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
| Myocardial infarction in recovery phase | contraindication | 418044006 | |
| Central nervous system depression | contraindication | 418072004 | |
| Unconscious | contraindication | 418107008 | |
| Porphyria | contraindication | 418470004 | |
| Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant | contraindication | 422681000 | |
| Dysfunction of sphincter of Oddi | contraindication | 430887001 | |
| Congenital long QT syndrome | contraindication | 442917000 | |
| Hypertensive urgency | contraindication | 443482000 | |
| Acute erosive gastritis | contraindication | 444926003 | |
| Severe dehydration | contraindication | 450316000 | |
| Acute exacerbation of asthma | contraindication | 708038006 | |
| Vitamin K Deficiency Induced Hypoprothrombinemia | contraindication | ||
| Cardiac Decompensation | contraindication | ||
| Severe Bone Marrow Depression | contraindication | ||
| Psychiatric Disturbance | contraindication | ||
| Organic Cardiac Disease | contraindication | ||
| Benzodiazepine Toxicity | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.98 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 588-42-1 | SECONDARY_CAS_RN |
| C0077377 | UMLSCUI |
| CHEBI:135172 | CHEBI |
| CHEMBL2111164 | ChEMBL_ID |
| CHEMBL3989711 | ChEMBL_ID |
| DB13719 | DRUGBANK_ID |
| C005873 | MESH_SUPPLEMENTAL_RECORD_UI |
| 11499 | PUBCHEM_CID |
| 741 | INN_ID |
| B9M85U075P | UNII |
| 000690 | NDDF |
| 004530 | NDDF |
| 56227008 | SNOMEDCT_US |
| B9M85U075P | INXIGHT DRUGS |
Pharmaceutical products:
None