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isosorbide mononitrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| NO2 - derivatives | 1506 | 16051-77-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
for prevention of angina pectoris; structure given in first source; a Russian drug
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 40 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 1.10 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 2.50 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 8.97 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 93 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.70 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 2 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 1 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 4.10 hours | Lombardo F, Berellini G, Obach RS |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,STK33,SYK,TEK,ZAP70 | 33 | |||
| kinase-selectivity-class | AXL,CDK9,GRK2,MAP2K6,TEK | 5 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 30, 1991 | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Myocardial infarction | 524.13 | 14.09 | 382 | 33587 | 105590 | 90488888 |
| Cardiospasm | 323.35 | 14.09 | 97 | 33872 | 3349 | 90591129 |
| Palmoplantar keratoderma | 321.67 | 14.09 | 97 | 33872 | 3410 | 90591068 |
| Pruritus genital | 300.69 | 14.09 | 98 | 33871 | 4460 | 90590018 |
| Cardiac failure congestive | 300.50 | 14.09 | 268 | 33701 | 98426 | 90496052 |
| Sleep terror | 286.48 | 14.09 | 94 | 33875 | 4370 | 90590108 |
| Subarachnoid haemorrhage | 280.17 | 14.09 | 136 | 33833 | 17768 | 90576710 |
| Atrial tachycardia | 278.23 | 14.09 | 99 | 33870 | 5891 | 90588587 |
| Carotid artery occlusion | 268.98 | 14.09 | 98 | 33871 | 6244 | 90588234 |
| Tension headache | 249.32 | 14.09 | 97 | 33872 | 7412 | 90587066 |
| Anosmia | 217.37 | 14.09 | 95 | 33874 | 9753 | 90584725 |
| Immunisation | 215.02 | 14.09 | 64 | 33905 | 2149 | 90592329 |
| Ventricular tachycardia | 207.17 | 14.09 | 124 | 33845 | 24584 | 90569894 |
| Acute myocardial infarction | 200.49 | 14.09 | 138 | 33831 | 34752 | 90559726 |
| Facial pain | 190.91 | 14.09 | 95 | 33874 | 13087 | 90581391 |
| Pain of skin | 178.65 | 14.09 | 97 | 33872 | 15985 | 90578493 |
| Vasculitis | 172.58 | 14.09 | 107 | 33862 | 22586 | 90571892 |
| Coronary artery disease | 172.30 | 14.09 | 124 | 33845 | 33499 | 90560979 |
| Angina pectoris | 166.25 | 14.09 | 129 | 33840 | 39031 | 90555447 |
| Lip swelling | 163.50 | 14.09 | 127 | 33842 | 38483 | 90555995 |
| Chest pain | 162.31 | 14.09 | 365 | 33604 | 319280 | 90275198 |
| Hypoglycaemia | 154.26 | 14.09 | 159 | 33810 | 69689 | 90524789 |
| Blindness | 147.73 | 14.09 | 103 | 33866 | 26465 | 90568013 |
| Diplopia | 142.80 | 14.09 | 104 | 33865 | 28610 | 90565868 |
| Muscle twitching | 139.67 | 14.09 | 96 | 33873 | 24106 | 90570372 |
| Eye pruritus | 139.53 | 14.09 | 103 | 33866 | 28924 | 90565554 |
| Transient ischaemic attack | 138.78 | 14.09 | 121 | 33848 | 43055 | 90551423 |
| Tinnitus | 136.94 | 14.09 | 120 | 33849 | 42982 | 90551496 |
| Cognitive disorder | 130.34 | 14.09 | 145 | 33824 | 69262 | 90525216 |
| Angioedema | 126.09 | 14.09 | 138 | 33831 | 64738 | 90529740 |
| Parkinsonism | 118.96 | 14.09 | 71 | 33898 | 13994 | 90580484 |
| Hyponatraemia | 117.83 | 14.09 | 193 | 33776 | 133345 | 90461133 |
| Dementia | 115.43 | 14.09 | 85 | 33884 | 23776 | 90570702 |
| Hallucination | 114.00 | 14.09 | 132 | 33837 | 65827 | 90528651 |
| Systemic lupus erythematosus | 111.18 | 14.09 | 6 | 33963 | 361890 | 90232588 |
| Infusion related reaction | 108.74 | 14.09 | 14 | 33955 | 416766 | 90177712 |
| Disturbance in attention | 103.56 | 14.09 | 107 | 33862 | 47002 | 90547476 |
| Melaena | 102.83 | 14.09 | 93 | 33876 | 34704 | 90559774 |
| Synovitis | 102.77 | 14.09 | 5 | 33964 | 329747 | 90264731 |
| Drug ineffective | 102.16 | 14.09 | 231 | 33738 | 1384067 | 89210411 |
| Blood cholesterol decreased | 101.49 | 14.09 | 35 | 33934 | 1896 | 90592582 |
| Acute kidney injury | 100.82 | 14.09 | 306 | 33663 | 320081 | 90274397 |
| Drug interaction | 96.49 | 14.09 | 274 | 33695 | 276179 | 90318299 |
| Blood glucose increased | 94.11 | 14.09 | 145 | 33824 | 95101 | 90499377 |
| Glossodynia | 93.87 | 14.09 | 7 | 33962 | 321772 | 90272706 |
| Contraindicated product administered | 93.29 | 14.09 | 7 | 33962 | 320132 | 90274346 |
| Peripheral circulatory failure | 91.84 | 14.09 | 31 | 33938 | 1573 | 90592905 |
| Maternal exposure during pregnancy | 91.76 | 14.09 | 13 | 33956 | 360050 | 90234428 |
| Arthropathy | 91.54 | 14.09 | 14 | 33955 | 366228 | 90228250 |
| Mucosal erosion | 91.41 | 14.09 | 32 | 33937 | 1813 | 90592665 |
| Atrial fibrillation | 90.53 | 14.09 | 172 | 33797 | 133439 | 90461039 |
| Wound | 90.09 | 14.09 | 6 | 33963 | 302974 | 90291504 |
| Rheumatoid arthritis | 85.90 | 14.09 | 16 | 33953 | 362598 | 90231880 |
| Hyperkalaemia | 84.91 | 14.09 | 113 | 33856 | 64851 | 90529627 |
| Rash papular | 84.08 | 14.09 | 66 | 33903 | 20289 | 90574189 |
| Hypotension | 82.70 | 14.09 | 289 | 33680 | 325108 | 90269370 |
| Atrioventricular block first degree | 82.65 | 14.09 | 47 | 33922 | 8464 | 90586014 |
| Cardiac failure | 80.48 | 14.09 | 146 | 33823 | 109350 | 90485128 |
| Angina unstable | 79.09 | 14.09 | 43 | 33926 | 7100 | 90587378 |
| Drug intolerance | 78.17 | 14.09 | 35 | 33934 | 447556 | 90146922 |
| Neuroglycopenia | 77.71 | 14.09 | 25 | 33944 | 1090 | 90593388 |
| Stomatitis | 77.28 | 14.09 | 7 | 33962 | 274691 | 90319787 |
| Intentional product misuse | 76.97 | 14.09 | 128 | 33841 | 89476 | 90505002 |
| Dehydration | 76.03 | 14.09 | 201 | 33768 | 194246 | 90400232 |
| Palpitations | 74.73 | 14.09 | 161 | 33808 | 136567 | 90457911 |
| Multiple drug therapy | 74.30 | 14.09 | 41 | 33928 | 6968 | 90587510 |
| Joint swelling | 72.54 | 14.09 | 50 | 33919 | 503250 | 90091228 |
| Hepatic enzyme increased | 69.90 | 14.09 | 24 | 33945 | 360712 | 90233766 |
| Rhabdomyolysis | 69.82 | 14.09 | 91 | 33878 | 51165 | 90543313 |
| Gastric polyps | 68.61 | 14.09 | 34 | 33935 | 4638 | 90589840 |
| Toxic epidermal necrolysis | 68.11 | 14.09 | 72 | 33897 | 32456 | 90562022 |
| Coronary arterial stent insertion | 67.92 | 14.09 | 29 | 33940 | 2811 | 90591667 |
| Dry skin | 66.71 | 14.09 | 119 | 33850 | 87954 | 90506524 |
| Blood urea increased | 66.69 | 14.09 | 69 | 33900 | 30344 | 90564134 |
| Stupor | 66.30 | 14.09 | 35 | 33934 | 5447 | 90589031 |
| Impaired healing | 65.78 | 14.09 | 6 | 33963 | 234193 | 90360285 |
| Syncope | 65.49 | 14.09 | 150 | 33819 | 132513 | 90461965 |
| Dizziness | 65.02 | 14.09 | 410 | 33559 | 588874 | 90005604 |
| Fall | 64.63 | 14.09 | 353 | 33616 | 481457 | 90113021 |
| Bradycardia | 64.42 | 14.09 | 114 | 33855 | 83733 | 90510745 |
| Swelling | 63.94 | 14.09 | 39 | 33930 | 419019 | 90175459 |
| Blood creatine increased | 63.72 | 14.09 | 37 | 33932 | 6930 | 90587548 |
| Diabetes mellitus inadequate control | 61.30 | 14.09 | 53 | 33916 | 18631 | 90575847 |
| Sinusitis | 61.19 | 14.09 | 26 | 33943 | 343062 | 90251416 |
| Therapeutic product effect decreased | 60.10 | 14.09 | 15 | 33954 | 277556 | 90316922 |
| Nasopharyngitis | 59.22 | 14.09 | 40 | 33929 | 407064 | 90187414 |
| Cardiorenal syndrome | 57.84 | 14.09 | 20 | 33949 | 1092 | 90593386 |
| Feeling abnormal | 56.57 | 14.09 | 164 | 33805 | 167071 | 90427407 |
| Drug dependence | 56.29 | 14.09 | 62 | 33907 | 29265 | 90565213 |
| Fibromyalgia | 56.05 | 14.09 | 6 | 33963 | 206263 | 90388215 |
| Psoriatic arthropathy | 54.20 | 14.09 | 10 | 33959 | 228325 | 90366153 |
| Muscle injury | 53.99 | 14.09 | 3 | 33966 | 176651 | 90417827 |
| Discomfort | 53.56 | 14.09 | 18 | 33951 | 274317 | 90320161 |
| Irritable bowel syndrome | 51.63 | 14.09 | 8 | 33961 | 207440 | 90387038 |
| Initial insomnia | 51.52 | 14.09 | 36 | 33933 | 9274 | 90585204 |
| Musculoskeletal stiffness | 50.47 | 14.09 | 24 | 33945 | 296508 | 90297970 |
| Hypersensitivity | 50.09 | 14.09 | 58 | 33911 | 454619 | 90139859 |
| Medication error | 50.09 | 14.09 | 103 | 33866 | 84549 | 90509929 |
| Urinary retention | 49.84 | 14.09 | 66 | 33903 | 37678 | 90556800 |
| Blood cholesterol increased | 49.61 | 14.09 | 9 | 33960 | 208003 | 90386475 |
| Bradykinesia | 49.06 | 14.09 | 31 | 33938 | 6757 | 90587721 |
| Fear of eating | 48.60 | 14.09 | 14 | 33955 | 418 | 90594060 |
| Exposure during pregnancy | 47.67 | 14.09 | 15 | 33954 | 238395 | 90356083 |
| Visual impairment | 45.91 | 14.09 | 131 | 33838 | 132234 | 90462244 |
| Amnesia | 45.29 | 14.09 | 115 | 33854 | 108390 | 90486088 |
| Myocardial ischaemia | 44.94 | 14.09 | 39 | 33930 | 13775 | 90580703 |
| Gastrointestinal haemorrhage | 44.48 | 14.09 | 102 | 33867 | 90146 | 90504332 |
| Dermatitis exfoliative | 44.36 | 14.09 | 27 | 33942 | 5509 | 90588969 |
| Renal impairment | 44.28 | 14.09 | 112 | 33857 | 105309 | 90489169 |
| Ill-defined disorder | 44.08 | 14.09 | 8 | 33961 | 184883 | 90409595 |
| Genital erosion | 43.29 | 14.09 | 13 | 33956 | 450 | 90594028 |
| Hyperhidrosis | 42.60 | 14.09 | 130 | 33839 | 136175 | 90458303 |
| Cerebrovascular accident | 42.58 | 14.09 | 122 | 33847 | 123411 | 90471067 |
| Tachycardia | 42.56 | 14.09 | 143 | 33826 | 157530 | 90436948 |
| Hiatus hernia | 42.54 | 14.09 | 50 | 33919 | 25311 | 90569167 |
| Heart rate increased | 42.37 | 14.09 | 115 | 33854 | 112787 | 90481691 |
| Blood potassium increased | 41.79 | 14.09 | 45 | 33924 | 20704 | 90573774 |
| Liver injury | 41.50 | 14.09 | 7 | 33962 | 170560 | 90423918 |
| Urticaria | 40.01 | 14.09 | 35 | 33934 | 312699 | 90281779 |
| Chronic kidney disease | 39.52 | 14.09 | 69 | 33900 | 50122 | 90544356 |
| Therapeutic product effect incomplete | 39.12 | 14.09 | 12 | 33957 | 193884 | 90400594 |
| Chronic obstructive pulmonary disease | 38.11 | 14.09 | 85 | 33884 | 73744 | 90520734 |
| Hypomagnesaemia | 37.71 | 14.09 | 56 | 33913 | 35532 | 90558946 |
| Iron deficiency anaemia | 36.97 | 14.09 | 45 | 33924 | 23617 | 90570861 |
| Joint range of motion decreased | 36.70 | 14.09 | 4 | 33965 | 135639 | 90458839 |
| COVID-19 | 36.14 | 14.09 | 142 | 33827 | 168701 | 90425777 |
| Anti-neutrophil cytoplasmic antibody positive vasculitis | 35.97 | 14.09 | 21 | 33948 | 3972 | 90590506 |
| Sodium retention | 35.73 | 14.09 | 9 | 33960 | 159 | 90594319 |
| Intestinal ischaemia | 34.96 | 14.09 | 28 | 33941 | 8855 | 90585623 |
| Infection | 34.91 | 14.09 | 51 | 33918 | 362043 | 90232435 |
| Hypotonia | 34.66 | 14.09 | 31 | 33938 | 11395 | 90583083 |
| Anxiety disorder | 34.38 | 14.09 | 22 | 33947 | 4900 | 90589578 |
| Muscle rigidity | 34.17 | 14.09 | 34 | 33935 | 14275 | 90580203 |
| Sleep disorder | 33.72 | 14.09 | 16 | 33953 | 198014 | 90396464 |
| Drug hypersensitivity | 33.43 | 14.09 | 78 | 33891 | 463531 | 90130947 |
| Hyperthyroidism | 32.21 | 14.09 | 37 | 33932 | 18273 | 90576205 |
| Injury | 32.02 | 14.09 | 17 | 33952 | 197332 | 90397146 |
| Upper gastrointestinal haemorrhage | 31.61 | 14.09 | 41 | 33928 | 22935 | 90571543 |
| Gastroenteritis bacterial | 31.60 | 14.09 | 10 | 33959 | 413 | 90594065 |
| Dyspnoea | 31.24 | 14.09 | 483 | 33486 | 880472 | 89714006 |
| International normalised ratio increased | 30.89 | 14.09 | 60 | 33909 | 47256 | 90547222 |
| Memory impairment | 30.86 | 14.09 | 151 | 33818 | 197093 | 90397385 |
| Dysuria | 30.80 | 14.09 | 54 | 33915 | 39347 | 90555131 |
| Gastrointestinal tract mucosal pigmentation | 30.22 | 14.09 | 11 | 33958 | 698 | 90593780 |
| Acute coronary syndrome | 30.18 | 14.09 | 28 | 33941 | 10785 | 90583693 |
| Blood creatinine increased | 30.09 | 14.09 | 95 | 33874 | 101291 | 90493187 |
| Product administration error | 30.06 | 14.09 | 43 | 33926 | 26380 | 90568098 |
| Wheezing | 30.02 | 14.09 | 27 | 33942 | 238053 | 90356425 |
| Cholecystitis | 29.25 | 14.09 | 34 | 33935 | 17006 | 90577472 |
| Motor dysfunction | 29.12 | 14.09 | 36 | 33933 | 19194 | 90575284 |
| Incorrect product administration duration | 28.98 | 14.09 | 36 | 33933 | 19286 | 90575192 |
| Osteoarthritis | 28.74 | 14.09 | 19 | 33950 | 195711 | 90398767 |
| Product use issue | 28.46 | 14.09 | 50 | 33919 | 329869 | 90264609 |
| Blood pressure decreased | 27.80 | 14.09 | 76 | 33893 | 74819 | 90519659 |
| Peptic ulcer | 27.59 | 14.09 | 20 | 33949 | 5455 | 90589023 |
| Metastatic neoplasm | 27.54 | 14.09 | 19 | 33950 | 4796 | 90589682 |
| Micturition disorder | 27.51 | 14.09 | 16 | 33953 | 3004 | 90591474 |
| Dialysis | 27.20 | 14.09 | 27 | 33942 | 11302 | 90583176 |
| General physical health deterioration | 27.01 | 14.09 | 58 | 33911 | 355057 | 90239421 |
| Arteriospasm coronary | 26.72 | 14.09 | 19 | 33950 | 5031 | 90589447 |
| Weight increased | 26.51 | 14.09 | 75 | 33894 | 417852 | 90176626 |
| Osteoporosis | 26.44 | 14.09 | 88 | 33881 | 96443 | 90498035 |
| Arthritis | 26.29 | 14.09 | 15 | 33954 | 167300 | 90427178 |
| Inflammation | 25.33 | 14.09 | 18 | 33951 | 178574 | 90415904 |
| Hypoaesthesia | 25.00 | 14.09 | 50 | 33919 | 314160 | 90280318 |
| Off label use | 24.49 | 14.09 | 280 | 33689 | 1101972 | 89492506 |
| Lung disorder | 24.18 | 14.09 | 13 | 33956 | 149870 | 90444608 |
| Sinus arrest | 23.98 | 14.09 | 13 | 33956 | 2133 | 90592345 |
| Prescribed overdose | 23.75 | 14.09 | 4 | 33965 | 97621 | 90496857 |
| Febrile neutropenia | 23.75 | 14.09 | 15 | 33954 | 158334 | 90436144 |
| Intentional overdose | 23.47 | 14.09 | 83 | 33886 | 93751 | 90500727 |
| Electrolyte imbalance | 23.22 | 14.09 | 36 | 33933 | 23709 | 90570769 |
| Vasodilatation | 22.94 | 14.09 | 14 | 33955 | 2870 | 90591608 |
| Cardiac failure acute | 22.51 | 14.09 | 25 | 33944 | 11904 | 90582574 |
| Cardiac disorder | 22.40 | 14.09 | 59 | 33910 | 56813 | 90537665 |
| Pain | 22.15 | 14.09 | 253 | 33716 | 996088 | 89598390 |
| Abdominal pain upper | 21.71 | 14.09 | 205 | 33764 | 332469 | 90262009 |
| Muscular weakness | 21.58 | 14.09 | 142 | 33827 | 206524 | 90387954 |
| Orthostatic hypotension | 21.40 | 14.09 | 48 | 33921 | 41779 | 90552699 |
| Conjunctivitis | 21.39 | 14.09 | 37 | 33932 | 26669 | 90567809 |
| Type 2 diabetes mellitus | 21.21 | 14.09 | 27 | 33942 | 203217 | 90391261 |
| Knee arthroplasty | 21.17 | 14.09 | 3 | 33966 | 83179 | 90511299 |
| Pulmonary oedema | 21.08 | 14.09 | 61 | 33908 | 62019 | 90532459 |
| Night sweats | 21.02 | 14.09 | 11 | 33958 | 128755 | 90465723 |
| Tachyphylaxis | 20.91 | 14.09 | 7 | 33962 | 346 | 90594132 |
| Wound infection | 20.72 | 14.09 | 7 | 33962 | 106395 | 90488083 |
| Labelled drug-drug interaction issue | 20.67 | 14.09 | 12 | 33957 | 2246 | 90592232 |
| Vitamin D deficiency | 20.60 | 14.09 | 29 | 33940 | 17527 | 90576951 |
| Cardiac failure chronic | 20.54 | 14.09 | 17 | 33952 | 5629 | 90588849 |
| Blood loss anaemia | 20.44 | 14.09 | 22 | 33947 | 10118 | 90584360 |
| Neutropenia | 20.39 | 14.09 | 33 | 33936 | 224871 | 90369607 |
| Pruritus | 20.33 | 14.09 | 300 | 33669 | 541225 | 90053253 |
| Mitral valve stenosis | 20.28 | 14.09 | 10 | 33959 | 1349 | 90593129 |
| Coronary artery bypass | 20.23 | 14.09 | 12 | 33957 | 2337 | 90592141 |
| Product residue present | 20.10 | 14.09 | 15 | 33954 | 4276 | 90590202 |
| Arteriosclerosis coronary artery | 19.64 | 14.09 | 21 | 33948 | 9582 | 90584896 |
| Road traffic accident | 19.41 | 14.09 | 8 | 33961 | 107618 | 90486860 |
| Shock | 19.40 | 14.09 | 37 | 33932 | 28741 | 90565737 |
| Conjunctival discolouration | 19.12 | 14.09 | 5 | 33964 | 103 | 90594375 |
| Autoimmune disorder | 18.99 | 14.09 | 3 | 33966 | 76741 | 90517737 |
| Liver disorder | 18.86 | 14.09 | 11 | 33958 | 121258 | 90473220 |
| Hip arthroplasty | 18.81 | 14.09 | 3 | 33966 | 76205 | 90518273 |
| Hyperparathyroidism | 18.69 | 14.09 | 13 | 33956 | 3324 | 90591154 |
| Lethargy | 18.58 | 14.09 | 59 | 33910 | 63080 | 90531398 |
| Electrocardiogram QRS complex prolonged | 18.55 | 14.09 | 18 | 33951 | 7330 | 90587148 |
| Renal failure | 18.17 | 14.09 | 97 | 33872 | 130910 | 90463568 |
| Back pain | 18.05 | 14.09 | 190 | 33779 | 316985 | 90277493 |
| C-reactive protein increased | 18.00 | 14.09 | 25 | 33944 | 181364 | 90413114 |
| Corneal abrasion | 17.63 | 14.09 | 9 | 33960 | 1307 | 90593171 |
| Liver function test increased | 17.57 | 14.09 | 5 | 33964 | 84850 | 90509628 |
| Sciatica | 17.55 | 14.09 | 8 | 33961 | 101374 | 90493104 |
| Nodal rhythm | 17.54 | 14.09 | 10 | 33959 | 1808 | 90592670 |
| Eosinophilic granulomatosis with polyangiitis | 16.91 | 14.09 | 11 | 33958 | 2519 | 90591959 |
| Acid base balance abnormal | 16.90 | 14.09 | 6 | 33963 | 354 | 90594124 |
| Gait inability | 16.84 | 14.09 | 18 | 33951 | 146438 | 90448040 |
| Tuberculosis of central nervous system | 16.84 | 14.09 | 6 | 33963 | 358 | 90594120 |
| Circulatory collapse | 16.77 | 14.09 | 32 | 33937 | 24872 | 90569606 |
| Mitral valve incompetence | 16.49 | 14.09 | 30 | 33939 | 22494 | 90571984 |
| Cerebral infarction | 16.48 | 14.09 | 33 | 33936 | 26563 | 90567915 |
| Prescribed underdose | 16.33 | 14.09 | 4 | 33965 | 75015 | 90519463 |
| Lupus myocarditis | 16.02 | 14.09 | 4 | 33965 | 68 | 90594410 |
| Haematoma | 15.88 | 14.09 | 41 | 33928 | 39007 | 90555471 |
| Post procedural haemorrhage | 15.85 | 14.09 | 18 | 33951 | 8780 | 90585698 |
| Musculoskeletal pain | 15.64 | 14.09 | 25 | 33944 | 171226 | 90423252 |
| Upper respiratory tract infection | 15.64 | 14.09 | 15 | 33954 | 128303 | 90466175 |
| Colitis microscopic | 15.48 | 14.09 | 20 | 33949 | 11139 | 90583339 |
| Cardiac arrest | 15.45 | 14.09 | 79 | 33890 | 104856 | 90489622 |
| Joint stiffness | 15.43 | 14.09 | 5 | 33964 | 78037 | 90516441 |
| Haemorrhoids | 15.21 | 14.09 | 32 | 33937 | 26670 | 90567808 |
| Disease progression | 15.13 | 14.09 | 22 | 33947 | 156593 | 90437885 |
| Restlessness | 15.04 | 14.09 | 38 | 33931 | 35682 | 90558796 |
| Gastrointestinal tract mucosal discolouration | 14.98 | 14.09 | 3 | 33966 | 17 | 90594461 |
| Glomerulonephritis rapidly progressive | 14.93 | 14.09 | 8 | 33961 | 1282 | 90593196 |
| Haemorrhage intracranial | 14.84 | 14.09 | 23 | 33946 | 15139 | 90579339 |
| Cutaneous lupus erythematosus | 14.83 | 14.09 | 11 | 33958 | 3107 | 90591371 |
| Procedural haemorrhage | 14.81 | 14.09 | 11 | 33958 | 3113 | 90591365 |
| Glomerular filtration rate abnormal | 14.62 | 14.09 | 8 | 33961 | 1337 | 90593141 |
| Device programming error | 14.62 | 14.09 | 5 | 33964 | 264 | 90594214 |
| Anal haemorrhage | 14.53 | 14.09 | 10 | 33959 | 2514 | 90591964 |
| Hypercholesterolaemia | 14.53 | 14.09 | 10 | 33959 | 100882 | 90493596 |
| Lower limb fracture | 14.26 | 14.09 | 7 | 33962 | 85006 | 90509472 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Myocardial infarction | 375.25 | 13.61 | 481 | 34012 | 123528 | 42463314 |
| Cardiac failure congestive | 318.81 | 13.61 | 369 | 34124 | 85233 | 42501609 |
| Cardiospasm | 225.69 | 13.61 | 77 | 34416 | 1830 | 42585012 |
| Angina pectoris | 210.41 | 13.61 | 190 | 34303 | 32706 | 42554136 |
| Palmoplantar keratoderma | 205.63 | 13.61 | 75 | 34418 | 2179 | 42584663 |
| Pruritus genital | 197.68 | 13.61 | 76 | 34417 | 2563 | 42584279 |
| Acute myocardial infarction | 195.30 | 13.61 | 238 | 34255 | 57927 | 42528915 |
| Chest pain | 187.81 | 13.61 | 374 | 34119 | 139156 | 42447686 |
| Sleep terror | 186.60 | 13.61 | 75 | 34418 | 2851 | 42583991 |
| Tension headache | 185.40 | 13.61 | 78 | 34415 | 3336 | 42583506 |
| Atrial tachycardia | 170.95 | 13.61 | 78 | 34415 | 4062 | 42582780 |
| Carotid artery occlusion | 169.98 | 13.61 | 78 | 34415 | 4116 | 42582726 |
| Facial pain | 159.51 | 13.61 | 75 | 34418 | 4185 | 42582657 |
| Coronary artery disease | 158.33 | 13.61 | 206 | 34287 | 53514 | 42533328 |
| Immunisation | 149.66 | 13.61 | 51 | 34442 | 1207 | 42585635 |
| Anosmia | 148.53 | 13.61 | 76 | 34417 | 5100 | 42581742 |
| Drug ineffective | 134.91 | 13.61 | 189 | 34304 | 630008 | 41956834 |
| Pain of skin | 124.46 | 13.61 | 79 | 34414 | 8001 | 42578841 |
| Lip swelling | 115.82 | 13.61 | 107 | 34386 | 18946 | 42567896 |
| Ventricular tachycardia | 113.69 | 13.61 | 131 | 34362 | 30029 | 42556813 |
| Muscle twitching | 110.58 | 13.61 | 85 | 34408 | 11695 | 42575147 |
| Angina unstable | 110.53 | 13.61 | 84 | 34409 | 11364 | 42575478 |
| Dizziness | 109.67 | 13.61 | 445 | 34048 | 248809 | 42338033 |
| Subarachnoid haemorrhage | 103.29 | 13.61 | 89 | 34404 | 14383 | 42572459 |
| Hypotension | 102.46 | 13.61 | 446 | 34047 | 257185 | 42329657 |
| Pericarditis | 96.60 | 13.61 | 83 | 34410 | 13361 | 42573481 |
| Eye pruritus | 95.60 | 13.61 | 77 | 34416 | 11335 | 42575507 |
| Off label use | 85.46 | 13.61 | 251 | 34242 | 638084 | 41948758 |
| Hallucination | 83.07 | 13.61 | 159 | 34334 | 57348 | 42529494 |
| Cardiac failure | 76.91 | 13.61 | 225 | 34268 | 106631 | 42480211 |
| Vasculitis | 76.31 | 13.61 | 84 | 34409 | 18310 | 42568532 |
| Blindness | 76.15 | 13.61 | 83 | 34410 | 17895 | 42568947 |
| Rash papular | 71.13 | 13.61 | 66 | 34427 | 11745 | 42575097 |
| Transient ischaemic attack | 69.29 | 13.61 | 109 | 34384 | 33630 | 42553212 |
| Cognitive disorder | 68.25 | 13.61 | 109 | 34384 | 34063 | 42552779 |
| Diplopia | 66.27 | 13.61 | 82 | 34411 | 20234 | 42566608 |
| Presyncope | 64.57 | 13.61 | 85 | 34408 | 22302 | 42564540 |
| Syncope | 62.80 | 13.61 | 200 | 34293 | 99206 | 42487636 |
| Amnesia | 62.78 | 13.61 | 95 | 34398 | 28342 | 42558500 |
| Blood glucose increased | 55.71 | 13.61 | 158 | 34335 | 73541 | 42513301 |
| Disturbance in attention | 55.21 | 13.61 | 92 | 34401 | 29774 | 42557068 |
| Febrile neutropenia | 54.91 | 13.61 | 42 | 34451 | 185661 | 42401181 |
| Product use in unapproved indication | 54.18 | 13.61 | 42 | 34451 | 184414 | 42402428 |
| Dyspnoea | 54.12 | 13.61 | 571 | 33922 | 442050 | 42144792 |
| Myocardial ischaemia | 52.09 | 13.61 | 68 | 34425 | 17694 | 42569148 |
| Anti-neutrophil cytoplasmic antibody positive vasculitis | 51.41 | 13.61 | 25 | 34468 | 1503 | 42585339 |
| Bradycardia | 51.27 | 13.61 | 169 | 34324 | 85315 | 42501527 |
| Angioedema | 51.24 | 13.61 | 109 | 34384 | 42368 | 42544474 |
| Migraine | 50.65 | 13.61 | 81 | 34412 | 25333 | 42561509 |
| Visual impairment | 50.14 | 13.61 | 109 | 34384 | 43004 | 42543838 |
| Tinnitus | 49.34 | 13.61 | 86 | 34407 | 28852 | 42557990 |
| Coronary arterial stent insertion | 49.32 | 13.61 | 34 | 34459 | 3951 | 42582891 |
| Palpitations | 47.62 | 13.61 | 118 | 34375 | 50679 | 42536163 |
| Alopecia | 46.06 | 13.61 | 84 | 34409 | 29192 | 42557650 |
| Blood potassium increased | 42.44 | 13.61 | 63 | 34430 | 18473 | 42568369 |
| International normalised ratio increased | 42.13 | 13.61 | 109 | 34384 | 48059 | 42538783 |
| Ventricular dysfunction | 41.18 | 13.61 | 32 | 34461 | 4471 | 42582371 |
| Left atrial dilatation | 40.81 | 13.61 | 25 | 34468 | 2377 | 42584465 |
| Drug abuse | 40.54 | 13.61 | 17 | 34476 | 104754 | 42482088 |
| Memory impairment | 40.23 | 13.61 | 110 | 34383 | 50112 | 42536730 |
| Dry skin | 39.85 | 13.61 | 107 | 34386 | 48231 | 42538611 |
| Venous pressure jugular increased | 39.79 | 13.61 | 17 | 34476 | 755 | 42586087 |
| Muscular weakness | 38.90 | 13.61 | 152 | 34341 | 83346 | 42503496 |
| Peripheral swelling | 38.60 | 13.61 | 160 | 34333 | 90110 | 42496732 |
| Orthostatic hypotension | 37.50 | 13.61 | 79 | 34414 | 30491 | 42556351 |
| Haematocrit increased | 36.81 | 13.61 | 24 | 34469 | 2543 | 42584299 |
| Gastrointestinal haemorrhage | 36.27 | 13.61 | 166 | 34327 | 97560 | 42489282 |
| Atrial fibrillation | 35.83 | 13.61 | 214 | 34279 | 139379 | 42447463 |
| Arteriospasm coronary | 35.56 | 13.61 | 30 | 34463 | 4708 | 42582134 |
| Mucosal dryness | 35.16 | 13.61 | 20 | 34473 | 1658 | 42585184 |
| Dehydration | 34.91 | 13.61 | 215 | 34278 | 141552 | 42445290 |
| Chest discomfort | 33.10 | 13.61 | 120 | 34373 | 63496 | 42523346 |
| Malignant neoplasm progression | 32.68 | 13.61 | 24 | 34469 | 108376 | 42478466 |
| Feeling abnormal | 32.46 | 13.61 | 127 | 34366 | 69659 | 42517183 |
| Malaise | 32.34 | 13.61 | 287 | 34206 | 211869 | 42374973 |
| Upper gastrointestinal haemorrhage | 32.29 | 13.61 | 74 | 34419 | 30225 | 42556617 |
| Heart rate increased | 31.65 | 13.61 | 105 | 34388 | 53150 | 42533692 |
| Neutropenia | 31.40 | 13.61 | 72 | 34421 | 199359 | 42387483 |
| Pulmonary oedema | 30.75 | 13.61 | 104 | 34389 | 53168 | 42533674 |
| Drug interaction | 29.97 | 13.61 | 339 | 34154 | 266660 | 42320182 |
| Venous pressure jugular decreased | 29.69 | 13.61 | 7 | 34486 | 39 | 42586803 |
| Hyperhidrosis | 27.34 | 13.61 | 145 | 34348 | 90367 | 42496475 |
| Lupus pneumonitis | 27.08 | 13.61 | 7 | 34486 | 60 | 42586782 |
| Acute kidney injury | 27.01 | 13.61 | 432 | 34061 | 366905 | 42219937 |
| Mast cell activation syndrome | 26.26 | 13.61 | 10 | 34483 | 328 | 42586514 |
| Hypovolaemia | 26.24 | 13.61 | 39 | 34454 | 11446 | 42575396 |
| Condition aggravated | 25.15 | 13.61 | 117 | 34376 | 260637 | 42326205 |
| Mucosal inflammation | 24.58 | 13.61 | 5 | 34488 | 49369 | 42537473 |
| Oedema peripheral | 23.30 | 13.61 | 189 | 34304 | 135887 | 42450955 |
| Abdominal pain upper | 22.70 | 13.61 | 129 | 34364 | 82480 | 42504362 |
| Cardiac failure chronic | 22.51 | 13.61 | 33 | 34460 | 9568 | 42577274 |
| Pancytopenia | 22.40 | 13.61 | 38 | 34455 | 117705 | 42469137 |
| Therapeutic product effect incomplete | 22.30 | 13.61 | 15 | 34478 | 70924 | 42515918 |
| Glomerular filtration rate decreased | 22.11 | 13.61 | 44 | 34449 | 16307 | 42570535 |
| Haemoglobin increased | 21.98 | 13.61 | 24 | 34469 | 5182 | 42581660 |
| Linear IgA disease | 21.56 | 13.61 | 16 | 34477 | 2087 | 42584755 |
| Drug reaction with eosinophilia and systemic symptoms | 21.50 | 13.61 | 4 | 34489 | 42071 | 42544771 |
| Contusion | 20.82 | 13.61 | 78 | 34415 | 41907 | 42544935 |
| General physical health deterioration | 20.40 | 13.61 | 59 | 34434 | 151187 | 42435655 |
| Abdominal discomfort | 20.34 | 13.61 | 117 | 34376 | 75138 | 42511704 |
| Disease progression | 20.15 | 13.61 | 55 | 34438 | 143601 | 42443241 |
| Coronary artery bypass | 20 | 13.61 | 22 | 34471 | 4788 | 42582054 |
| Wrong patient received product | 19.62 | 13.61 | 19 | 34474 | 3564 | 42583278 |
| Nodal arrhythmia | 19.61 | 13.61 | 11 | 34482 | 888 | 42585954 |
| Rhabdomyolysis | 19.60 | 13.61 | 119 | 34374 | 77900 | 42508942 |
| Arrhythmia | 19.25 | 13.61 | 74 | 34419 | 40243 | 42546599 |
| Gravitational oedema | 19.17 | 13.61 | 10 | 34483 | 698 | 42586144 |
| Excessive cerumen production | 19.14 | 13.61 | 8 | 34485 | 336 | 42586506 |
| Fluid retention | 18.48 | 13.61 | 62 | 34431 | 31557 | 42555285 |
| Melaena | 18.40 | 13.61 | 71 | 34422 | 38675 | 42548167 |
| Tachycardia | 18.17 | 13.61 | 142 | 34351 | 100945 | 42485897 |
| Stent placement | 18.06 | 13.61 | 22 | 34471 | 5338 | 42581504 |
| Infection | 17.99 | 13.61 | 40 | 34453 | 112028 | 42474814 |
| Pterygium | 17.89 | 13.61 | 6 | 34487 | 135 | 42586707 |
| Prinzmetal angina | 17.80 | 13.61 | 12 | 34481 | 1345 | 42585497 |
| Ischaemic cardiomyopathy | 17.63 | 13.61 | 24 | 34469 | 6498 | 42580344 |
| Faeces discoloured | 17.52 | 13.61 | 41 | 34452 | 16973 | 42569869 |
| Loss of control of legs | 17.47 | 13.61 | 10 | 34483 | 839 | 42586003 |
| Pyrexia | 17.37 | 13.61 | 220 | 34273 | 393822 | 42193020 |
| Drug intolerance | 17.17 | 13.61 | 24 | 34469 | 80400 | 42506442 |
| Hirsutism | 17.15 | 13.61 | 7 | 34486 | 277 | 42586565 |
| Drug ineffective for unapproved indication | 17.04 | 13.61 | 8 | 34485 | 46155 | 42540687 |
| Rash | 16.97 | 13.61 | 143 | 34350 | 276811 | 42310031 |
| Nitritoid reaction | 16.86 | 13.61 | 4 | 34489 | 23 | 42586819 |
| Myalgia | 16.73 | 13.61 | 134 | 34359 | 95946 | 42490896 |
| Toxicity to various agents | 16.54 | 13.61 | 113 | 34380 | 229023 | 42357819 |
| Cardiac failure acute | 16.45 | 13.61 | 35 | 34458 | 13598 | 42573244 |
| Blood pressure systolic decreased | 16.05 | 13.61 | 20 | 34473 | 4967 | 42581875 |
| Nasal crusting | 16.04 | 13.61 | 8 | 34485 | 508 | 42586334 |
| Injection site pain | 15.90 | 13.61 | 14 | 34479 | 57784 | 42529058 |
| Septic arthritis staphylococcal | 15.85 | 13.61 | 8 | 34485 | 521 | 42586321 |
| Infusion related reaction | 15.25 | 13.61 | 16 | 34477 | 60790 | 42526052 |
| Treatment failure | 15.13 | 13.61 | 17 | 34476 | 62607 | 42524235 |
| Oral mucosal blistering | 15.10 | 13.61 | 14 | 34479 | 2487 | 42584355 |
| Myelosuppression | 14.95 | 13.61 | 7 | 34486 | 40454 | 42546388 |
| Seizure | 14.86 | 13.61 | 49 | 34444 | 120512 | 42466330 |
| Electrocardiogram ST segment elevation | 14.78 | 13.61 | 21 | 34472 | 5918 | 42580924 |
| Rheumatoid arthritis | 14.70 | 13.61 | 8 | 34485 | 42432 | 42544410 |
| Neutrophil count decreased | 14.48 | 13.61 | 18 | 34475 | 63397 | 42523445 |
| Product use issue | 14.38 | 13.61 | 25 | 34468 | 76726 | 42510116 |
| Drug dependence | 14.37 | 13.61 | 3 | 34490 | 29091 | 42557751 |
| Sprue-like enteropathy | 14.34 | 13.61 | 8 | 34485 | 639 | 42586203 |
| Coronary artery stenosis | 14.12 | 13.61 | 28 | 34465 | 10351 | 42576491 |
| Cardiac disorder | 13.82 | 13.61 | 77 | 34416 | 48855 | 42537987 |
| Pulmonary embolism | 13.80 | 13.61 | 50 | 34443 | 119562 | 42467280 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Myocardial infarction | 906.54 | 12.68 | 796 | 61318 | 191287 | 110335898 |
| Cardiac failure congestive | 604.60 | 12.68 | 571 | 61543 | 150429 | 110376756 |
| Cardiospasm | 515.28 | 12.68 | 166 | 61948 | 4801 | 110522384 |
| Palmoplantar keratoderma | 494.04 | 12.68 | 164 | 61950 | 5223 | 110521962 |
| Pruritus genital | 470.94 | 12.68 | 166 | 61948 | 6356 | 110520829 |
| Sleep terror | 449.83 | 12.68 | 161 | 61953 | 6449 | 110520736 |
| Atrial tachycardia | 426.17 | 12.68 | 169 | 61945 | 9009 | 110518176 |
| Carotid artery occlusion | 415.96 | 12.68 | 168 | 61946 | 9397 | 110517788 |
| Tension headache | 408.19 | 12.68 | 166 | 61948 | 9452 | 110517733 |
| Acute myocardial infarction | 400.11 | 12.68 | 350 | 61764 | 83427 | 110443758 |
| Anosmia | 357.18 | 12.68 | 163 | 61951 | 12309 | 110514876 |
| Subarachnoid haemorrhage | 349.04 | 12.68 | 214 | 61900 | 29488 | 110497697 |
| Immunisation | 336.80 | 12.68 | 108 | 62006 | 3075 | 110524110 |
| Facial pain | 325.06 | 12.68 | 163 | 61951 | 15176 | 110512009 |
| Angina pectoris | 319.20 | 12.68 | 271 | 61843 | 62024 | 110465161 |
| Coronary artery disease | 305.68 | 12.68 | 281 | 61833 | 71409 | 110455776 |
| Ventricular tachycardia | 299.03 | 12.68 | 238 | 61876 | 49771 | 110477414 |
| Pain of skin | 297.66 | 12.68 | 168 | 61946 | 19861 | 110507324 |
| Chest pain | 289.68 | 12.68 | 647 | 61467 | 375728 | 110151457 |
| Lip swelling | 271.07 | 12.68 | 226 | 61888 | 50441 | 110476744 |
| Muscle twitching | 247.29 | 12.68 | 173 | 61941 | 29762 | 110497423 |
| Vasculitis | 234.52 | 12.68 | 180 | 61934 | 35693 | 110491492 |
| Eye pruritus | 224.28 | 12.68 | 169 | 61945 | 32606 | 110494579 |
| Blindness | 215.12 | 12.68 | 172 | 61942 | 36187 | 110490998 |
| Diplopia | 205.90 | 12.68 | 178 | 61936 | 41716 | 110485469 |
| Hallucination | 202.77 | 12.68 | 267 | 61847 | 101165 | 110426020 |
| Angina unstable | 202.29 | 12.68 | 122 | 61992 | 16310 | 110510875 |
| Transient ischaemic attack | 196.91 | 12.68 | 210 | 61904 | 63772 | 110463413 |
| Cognitive disorder | 194.81 | 12.68 | 243 | 61871 | 87268 | 110439917 |
| Hypotension | 192.75 | 12.68 | 689 | 61425 | 523160 | 110004025 |
| Drug ineffective | 191.20 | 12.68 | 353 | 61761 | 1520187 | 109006998 |
| Tinnitus | 169.39 | 12.68 | 189 | 61925 | 60351 | 110466834 |
| Disturbance in attention | 160.66 | 12.68 | 186 | 61928 | 61809 | 110465376 |
| Angioedema | 159.04 | 12.68 | 234 | 61880 | 98266 | 110428919 |
| Rash papular | 153.45 | 12.68 | 126 | 61988 | 27513 | 110499672 |
| Acute kidney injury | 150.41 | 12.68 | 730 | 61384 | 634700 | 109892485 |
| Dizziness | 146.29 | 12.68 | 775 | 61339 | 697418 | 109829767 |
| Blood glucose increased | 141.21 | 12.68 | 261 | 61853 | 132235 | 110394950 |
| Cardiac failure | 141.19 | 12.68 | 320 | 61794 | 187306 | 110339879 |
| Infusion related reaction | 131.46 | 12.68 | 27 | 62087 | 381135 | 110146050 |
| Atrial fibrillation | 130.78 | 12.68 | 352 | 61762 | 229290 | 110297895 |
| Coronary arterial stent insertion | 128.68 | 12.68 | 64 | 62050 | 5851 | 110521334 |
| Synovitis | 128.66 | 12.68 | 6 | 62108 | 274086 | 110253099 |
| Syncope | 127.14 | 12.68 | 322 | 61792 | 202214 | 110324971 |
| Bradycardia | 125.73 | 12.68 | 273 | 61841 | 155244 | 110371941 |
| Drug intolerance | 124.28 | 12.68 | 37 | 62077 | 406475 | 110120710 |
| Drug interaction | 119.92 | 12.68 | 577 | 61537 | 499606 | 110027579 |
| Rheumatoid arthritis | 117.21 | 12.68 | 15 | 62099 | 299598 | 110227587 |
| Dehydration | 115.98 | 12.68 | 383 | 61731 | 279128 | 110248057 |
| Hypoglycaemia | 115.37 | 12.68 | 222 | 61892 | 115882 | 110411303 |
| Palpitations | 114.74 | 12.68 | 267 | 61847 | 158945 | 110368240 |
| Dry skin | 109.62 | 12.68 | 208 | 61906 | 107445 | 110419740 |
| Melaena | 109.03 | 12.68 | 162 | 61952 | 68595 | 110458590 |
| Arthropathy | 108.67 | 12.68 | 16 | 62098 | 287506 | 110239679 |
| Systemic lupus erythematosus | 106.40 | 12.68 | 10 | 62104 | 254328 | 110272857 |
| Hyperkalaemia | 102.55 | 12.68 | 232 | 61882 | 135564 | 110391621 |
| Gastrointestinal haemorrhage | 100.59 | 12.68 | 260 | 61854 | 165258 | 110361927 |
| Sinusitis | 100.26 | 12.68 | 22 | 62092 | 296666 | 110230519 |
| Maternal exposure during pregnancy | 99.11 | 12.68 | 13 | 62101 | 254870 | 110272315 |
| Treatment failure | 99.03 | 12.68 | 18 | 62096 | 277216 | 110249969 |
| Wound | 98.65 | 12.68 | 9 | 62105 | 234428 | 110292757 |
| Stomatitis | 97.71 | 12.68 | 17 | 62097 | 270225 | 110256960 |
| Off label use | 97.60 | 12.68 | 473 | 61641 | 1499712 | 109027473 |
| Rhabdomyolysis | 95.75 | 12.68 | 210 | 61904 | 120191 | 110406994 |
| Feeling abnormal | 91.03 | 12.68 | 265 | 61849 | 180446 | 110346739 |
| Amnesia | 89.72 | 12.68 | 189 | 61925 | 105219 | 110421966 |
| Contraindicated product administered | 88.92 | 12.68 | 16 | 62098 | 248251 | 110278934 |
| Mucosal erosion | 87.49 | 12.68 | 39 | 62075 | 2785 | 110524400 |
| Hyponatraemia | 87.36 | 12.68 | 295 | 61819 | 217358 | 110309827 |
| Blood potassium increased | 86.53 | 12.68 | 100 | 62014 | 33149 | 110494036 |
| Joint swelling | 86.49 | 12.68 | 73 | 62041 | 442772 | 110084413 |
| Pemphigus | 85.72 | 12.68 | 10 | 62104 | 214560 | 110312625 |
| Helicobacter infection | 85.27 | 12.68 | 4 | 62110 | 181873 | 110345312 |
| Glossodynia | 84.70 | 12.68 | 12 | 62102 | 221992 | 110305193 |
| Visual impairment | 84.60 | 12.68 | 214 | 61900 | 134214 | 110392971 |
| Myocardial ischaemia | 84.58 | 12.68 | 89 | 62025 | 26595 | 110500590 |
| Fibromyalgia | 82.67 | 12.68 | 3 | 62111 | 170906 | 110356279 |
| Anti-neutrophil cytoplasmic antibody positive vasculitis | 81.99 | 12.68 | 46 | 62068 | 5371 | 110521814 |
| Psoriatic arthropathy | 81.59 | 12.68 | 8 | 62106 | 196753 | 110330432 |
| Dementia | 80.32 | 12.68 | 94 | 62020 | 31579 | 110495606 |
| Peripheral circulatory failure | 79.25 | 12.68 | 32 | 62082 | 1787 | 110525398 |
| Impaired healing | 76.55 | 12.68 | 10 | 62104 | 196707 | 110330478 |
| Blood cholesterol decreased | 76.19 | 12.68 | 35 | 62079 | 2681 | 110524504 |
| Nasopharyngitis | 75.78 | 12.68 | 66 | 62048 | 394295 | 110132890 |
| Hyperhidrosis | 75.27 | 12.68 | 254 | 61860 | 187044 | 110340141 |
| Swelling | 74.71 | 12.68 | 53 | 62061 | 350988 | 110176197 |
| Therapeutic product effect decreased | 73.25 | 12.68 | 23 | 62091 | 244293 | 110282892 |
| Intentional product misuse | 72.87 | 12.68 | 201 | 61913 | 132703 | 110394482 |
| Irritable bowel syndrome | 72.72 | 12.68 | 5 | 62109 | 164210 | 110362975 |
| Dyspnoea | 71.99 | 12.68 | 942 | 61172 | 1105930 | 109421255 |
| Atrioventricular block first degree | 68.98 | 12.68 | 60 | 62054 | 14165 | 110513020 |
| Gastric polyps | 67.96 | 12.68 | 41 | 62073 | 5482 | 110521703 |
| Neuroglycopenia | 67.56 | 12.68 | 25 | 62089 | 1101 | 110526084 |
| International normalised ratio increased | 67.45 | 12.68 | 150 | 61964 | 86622 | 110440563 |
| Febrile neutropenia | 67.17 | 12.68 | 48 | 62066 | 316719 | 110210466 |
| Heart rate increased | 66.81 | 12.68 | 205 | 61909 | 143629 | 110383556 |
| Upper gastrointestinal haemorrhage | 66.80 | 12.68 | 109 | 62005 | 49987 | 110477198 |
| Muscle injury | 66.32 | 12.68 | 3 | 62111 | 140804 | 110386381 |
| Hepatic enzyme increased | 64.98 | 12.68 | 51 | 62063 | 320841 | 110206344 |
| Musculoskeletal stiffness | 62.54 | 12.68 | 40 | 62074 | 279782 | 110247403 |
| Therapeutic product effect incomplete | 62.05 | 12.68 | 24 | 62090 | 223781 | 110303404 |
| Presyncope | 62.01 | 12.68 | 104 | 62010 | 48783 | 110478402 |
| Parkinsonism | 61.58 | 12.68 | 69 | 62045 | 22118 | 110505067 |
| Infection | 61.07 | 12.68 | 68 | 62046 | 362132 | 110165053 |
| Blood creatine increased | 58.72 | 12.68 | 50 | 62064 | 11471 | 110515714 |
| Multiple drug therapy | 58.56 | 12.68 | 43 | 62071 | 7971 | 110519214 |
| Tachycardia | 58.23 | 12.68 | 267 | 61847 | 226378 | 110300807 |
| Orthostatic hypotension | 57.78 | 12.68 | 120 | 61994 | 66129 | 110461056 |
| Product use in unapproved indication | 56.60 | 12.68 | 103 | 62011 | 447274 | 110079911 |
| Hypersensitivity | 55.71 | 12.68 | 88 | 62026 | 403910 | 110123275 |
| Blood urea increased | 55.69 | 12.68 | 106 | 62008 | 54851 | 110472334 |
| Exposure during pregnancy | 55.37 | 12.68 | 13 | 62101 | 167411 | 110359774 |
| Osteoarthritis | 55.08 | 12.68 | 17 | 62097 | 182606 | 110344579 |
| Discomfort | 54.77 | 12.68 | 26 | 62088 | 214681 | 110312504 |
| Pulmonary oedema | 53.95 | 12.68 | 151 | 61963 | 100508 | 110426677 |
| Memory impairment | 52.82 | 12.68 | 235 | 61879 | 196709 | 110330476 |
| Fear of eating | 52.13 | 12.68 | 17 | 62097 | 511 | 110526674 |
| Arteriospasm coronary | 51.58 | 12.68 | 42 | 62072 | 9058 | 110518127 |
| Ill-defined disorder | 50.27 | 12.68 | 13 | 62101 | 156840 | 110370345 |
| Inflammation | 49.91 | 12.68 | 23 | 62091 | 193215 | 110333970 |
| Muscular weakness | 49.89 | 12.68 | 273 | 61841 | 248195 | 110278990 |
| General physical health deterioration | 49.38 | 12.68 | 103 | 62011 | 425192 | 110101993 |
| Cardiac failure chronic | 49.09 | 12.68 | 49 | 62065 | 13762 | 110513423 |
| Joint range of motion decreased | 47.86 | 12.68 | 6 | 62108 | 121826 | 110405359 |
| Sleep disorder | 46.32 | 12.68 | 27 | 62087 | 198617 | 110328568 |
| Coronary artery bypass | 45.46 | 12.68 | 33 | 62081 | 6009 | 110521176 |
| Renal impairment | 45.46 | 12.68 | 218 | 61896 | 188227 | 110338958 |
| Ventricular dysfunction | 45.41 | 12.68 | 36 | 62078 | 7475 | 110519710 |
| Urticaria | 45.34 | 12.68 | 68 | 62046 | 318789 | 110208396 |
| Left atrial dilatation | 45.28 | 12.68 | 27 | 62087 | 3533 | 110523652 |
| Blood cholesterol increased | 44.70 | 12.68 | 24 | 62090 | 184761 | 110342424 |
| Stupor | 44.45 | 12.68 | 37 | 62077 | 8228 | 110518957 |
| Arthritis | 43.19 | 12.68 | 20 | 62094 | 167566 | 110359619 |
| Blood pressure decreased | 40.97 | 12.68 | 150 | 61964 | 114941 | 110412244 |
| Neutropenia | 40.78 | 12.68 | 94 | 62020 | 374526 | 110152659 |
| Condition aggravated | 40.18 | 12.68 | 245 | 61869 | 734591 | 109792594 |
| Product use issue | 39.18 | 12.68 | 72 | 62042 | 311623 | 110215562 |
| Cerebrovascular accident | 38.97 | 12.68 | 203 | 61911 | 181081 | 110346104 |
| Fall | 38.79 | 12.68 | 513 | 61601 | 602969 | 109924216 |
| Diabetes mellitus inadequate control | 38.63 | 12.68 | 64 | 62050 | 29711 | 110497474 |
| Cardiac failure acute | 38.54 | 12.68 | 57 | 62057 | 24021 | 110503164 |
| Dermatitis exfoliative | 38.03 | 12.68 | 39 | 62075 | 11308 | 110515877 |
| Weight increased | 37.58 | 12.68 | 116 | 61998 | 419528 | 110107657 |
| Cardiorenal syndrome | 36.61 | 12.68 | 19 | 62095 | 1899 | 110525286 |
| Venous pressure jugular increased | 36.61 | 12.68 | 17 | 62097 | 1335 | 110525850 |
| Injury | 36.08 | 12.68 | 28 | 62086 | 177237 | 110349948 |
| Initial insomnia | 35.35 | 12.68 | 36 | 62078 | 10353 | 110516832 |
| Drug abuse | 34.89 | 12.68 | 29 | 62085 | 177382 | 110349803 |
| Acute coronary syndrome | 34.55 | 12.68 | 53 | 62061 | 23059 | 110504126 |
| Liver injury | 34.28 | 12.68 | 21 | 62093 | 150392 | 110376793 |
| Drug hypersensitivity | 34.28 | 12.68 | 135 | 61979 | 453955 | 110073230 |
| Wheezing | 33.85 | 12.68 | 57 | 62057 | 255173 | 110272012 |
| Ischaemic cardiomyopathy | 33.34 | 12.68 | 31 | 62083 | 7980 | 110519205 |
| Glomerular filtration rate decreased | 33.31 | 12.68 | 59 | 62055 | 28897 | 110498288 |
| Hiatus hernia | 32.73 | 12.68 | 57 | 62057 | 27549 | 110499636 |
| Mucosal inflammation | 32.72 | 12.68 | 7 | 62107 | 96134 | 110431051 |
| Arteriosclerosis coronary artery | 32.60 | 12.68 | 54 | 62060 | 25064 | 110502121 |
| Lung disorder | 32.34 | 12.68 | 32 | 62082 | 180015 | 110347170 |
| Toxic epidermal necrolysis | 32.28 | 12.68 | 87 | 62027 | 56640 | 110470545 |
| Blood creatinine increased | 31.51 | 12.68 | 193 | 61921 | 182696 | 110344489 |
| Grip strength decreased | 31.36 | 12.68 | 4 | 62110 | 80170 | 110447015 |
| Gastrointestinal tract mucosal pigmentation | 31.33 | 12.68 | 15 | 62099 | 1262 | 110525923 |
| Paraesthesia | 31.21 | 12.68 | 68 | 62046 | 276453 | 110250732 |
| Peripheral venous disease | 31.03 | 12.68 | 5 | 62109 | 84112 | 110443073 |
| Genital erosion | 31.02 | 12.68 | 13 | 62101 | 798 | 110526387 |
| Prinzmetal angina | 30.94 | 12.68 | 18 | 62096 | 2251 | 110524934 |
| Night sweats | 30.13 | 12.68 | 19 | 62095 | 133964 | 110393221 |
| Lymphorrhoea | 30.05 | 12.68 | 9 | 62105 | 203 | 110526982 |
| Drug reaction with eosinophilia and systemic symptoms | 30.02 | 12.68 | 5 | 62109 | 82090 | 110445095 |
| C-reactive protein increased | 29.51 | 12.68 | 48 | 62066 | 217871 | 110309314 |
| Hypoaesthesia | 29.45 | 12.68 | 85 | 62029 | 314138 | 110213047 |
| Malignant neoplasm progression | 29.15 | 12.68 | 33 | 62081 | 174534 | 110352651 |
| Wound infection | 29.04 | 12.68 | 9 | 62105 | 96456 | 110430729 |
| Liver function test abnormal | 29 | 12.68 | 95 | 62019 | 68855 | 110458330 |
| Bradykinesia | 29.00 | 12.68 | 33 | 62081 | 10755 | 110516430 |
| Sciatica | 28.95 | 12.68 | 8 | 62106 | 92391 | 110434794 |
| Hypomagnesaemia | 28.91 | 12.68 | 87 | 62027 | 60283 | 110466902 |
| Sodium retention | 28.73 | 12.68 | 9 | 62105 | 237 | 110526948 |
| Gravitational oedema | 28.41 | 12.68 | 16 | 62098 | 1882 | 110525303 |
| Haematocrit increased | 28.35 | 12.68 | 23 | 62091 | 4936 | 110522249 |
| COVID-19 | 27.89 | 12.68 | 234 | 61880 | 244826 | 110282359 |
| Injection site reaction | 27.38 | 12.68 | 8 | 62106 | 89062 | 110438123 |
| Venous pressure jugular decreased | 27.19 | 12.68 | 7 | 62107 | 88 | 110527097 |
| Arrhythmia | 26.74 | 12.68 | 93 | 62021 | 69482 | 110457703 |
| Renal failure | 26.67 | 12.68 | 218 | 61896 | 226356 | 110300829 |
| Rash | 26.63 | 12.68 | 314 | 61800 | 820650 | 109706535 |
| Migraine | 26.39 | 12.68 | 176 | 61938 | 171476 | 110355709 |
| Haemoglobin increased | 26.33 | 12.68 | 29 | 62085 | 9118 | 110518067 |
| Autoimmune disorder | 26.27 | 12.68 | 3 | 62111 | 65480 | 110461705 |
| Malaise | 26.23 | 12.68 | 526 | 61588 | 671293 | 109855892 |
| Injection site pain | 26.20 | 12.68 | 37 | 62077 | 177885 | 110349300 |
| Road traffic accident | 25.89 | 12.68 | 14 | 62100 | 107384 | 110419801 |
| Gastroenteritis bacterial | 25.76 | 12.68 | 10 | 62104 | 503 | 110526682 |
| Lower gastrointestinal haemorrhage | 25.70 | 12.68 | 41 | 62073 | 18445 | 110508740 |
| Atrioventricular block | 25.65 | 12.68 | 39 | 62075 | 16838 | 110510347 |
| Faeces discoloured | 25.60 | 12.68 | 58 | 62056 | 33890 | 110493295 |
| Prescribed overdose | 24.92 | 12.68 | 9 | 62105 | 87572 | 110439613 |
| Mucosal dryness | 24.85 | 12.68 | 20 | 62094 | 4243 | 110522942 |
| Lupus pneumonitis | 24.75 | 12.68 | 7 | 62107 | 128 | 110527057 |
| Asthma | 24.72 | 12.68 | 66 | 62048 | 250225 | 110276960 |
| Hypovolaemia | 24.72 | 12.68 | 44 | 62070 | 21630 | 110505555 |
| Myelosuppression | 24.71 | 12.68 | 11 | 62103 | 94329 | 110432856 |
| Lower limb fracture | 24.61 | 12.68 | 6 | 62108 | 75342 | 110451843 |
| Gastritis erosive | 24.59 | 12.68 | 32 | 62082 | 11968 | 110515217 |
| Electrocardiogram ST segment elevation | 24.59 | 12.68 | 28 | 62086 | 9132 | 110518053 |
| Back pain | 24.47 | 12.68 | 317 | 61797 | 370679 | 110156506 |
| Upper respiratory tract infection | 23.98 | 12.68 | 23 | 62091 | 131305 | 110395880 |
| Incorrect product administration duration | 23.88 | 12.68 | 42 | 62072 | 20456 | 110506729 |
| Abdominal pain upper | 23.74 | 12.68 | 300 | 61814 | 348811 | 110178374 |
| Blood loss anaemia | 23.73 | 12.68 | 39 | 62075 | 17986 | 110509199 |
| Knee arthroplasty | 23.65 | 12.68 | 4 | 62110 | 64944 | 110462241 |
| Dry mouth | 23.54 | 12.68 | 48 | 62066 | 199900 | 110327285 |
| Coronary artery occlusion | 23.34 | 12.68 | 36 | 62078 | 15736 | 110511449 |
| Bundle branch block left | 22.81 | 12.68 | 32 | 62082 | 12856 | 110514329 |
| Oedema peripheral | 22.59 | 12.68 | 283 | 61831 | 328377 | 110198808 |
| Drug ineffective for unapproved indication | 22.55 | 12.68 | 15 | 62099 | 102823 | 110424362 |
| Myalgia | 22.53 | 12.68 | 207 | 61907 | 222174 | 110305011 |
| Pruritus | 22.25 | 12.68 | 454 | 61660 | 581106 | 109946079 |
| Type 2 diabetes mellitus | 22.20 | 12.68 | 41 | 62073 | 177191 | 110349994 |
| Cytokine release syndrome | 22.19 | 12.68 | 6 | 62108 | 70300 | 110456885 |
| Chest discomfort | 21.95 | 12.68 | 170 | 61944 | 173678 | 110353507 |
| Chronic obstructive pulmonary disease | 21.92 | 12.68 | 120 | 61994 | 109038 | 110418147 |
| Sinus bradycardia | 21.82 | 12.68 | 50 | 62064 | 29433 | 110497752 |
| Taste disorder | 21.76 | 12.68 | 5 | 62109 | 65382 | 110461803 |
| Cholecystitis | 21.53 | 12.68 | 46 | 62068 | 25836 | 110501349 |
| Disease progression | 21.44 | 12.68 | 68 | 62046 | 243966 | 110283219 |
| Medication error | 21.28 | 12.68 | 116 | 61998 | 105250 | 110421935 |
| Coronary artery stenosis | 21.20 | 12.68 | 32 | 62082 | 13726 | 110513459 |
| Frequent bowel movements | 20.89 | 12.68 | 7 | 62107 | 71383 | 110455802 |
| Chronic kidney disease | 20.41 | 12.68 | 91 | 62023 | 76200 | 110450985 |
| Colitis ulcerative | 20.29 | 12.68 | 9 | 62105 | 77354 | 110449831 |
| Urinary retention | 20.08 | 12.68 | 85 | 62029 | 69598 | 110457587 |
| Mitral valve incompetence | 19.86 | 12.68 | 52 | 62062 | 33277 | 110493908 |
| Cardiac disorder | 19.66 | 12.68 | 90 | 62024 | 76190 | 110450995 |
| Neoplasm progression | 19.49 | 12.68 | 6 | 62108 | 64589 | 110462596 |
| Obesity | 19.39 | 12.68 | 21 | 62093 | 113330 | 110413855 |
| Weight decreased | 19.29 | 12.68 | 169 | 61945 | 467888 | 110059297 |
| Stent placement | 19.23 | 12.68 | 22 | 62092 | 7212 | 110519973 |
| Hip arthroplasty | 19.12 | 12.68 | 4 | 62110 | 55809 | 110471376 |
| Joint stiffness | 18.98 | 12.68 | 7 | 62107 | 67236 | 110459949 |
| Wrong patient received product | 18.94 | 12.68 | 21 | 62093 | 6653 | 110520532 |
| Mitral valve stenosis | 18.79 | 12.68 | 11 | 62103 | 1391 | 110525794 |
| Pain | 18.59 | 12.68 | 402 | 61712 | 954553 | 109572632 |
| Gastrointestinal disorder | 18.19 | 12.68 | 72 | 62042 | 241880 | 110285305 |
| Ventricular hypertrophy | 18.01 | 12.68 | 21 | 62093 | 7024 | 110520161 |
| Cardiac arrest | 17.88 | 12.68 | 179 | 61935 | 196574 | 110330611 |
| Injection site erythema | 17.78 | 12.68 | 16 | 62098 | 94160 | 110433025 |
| Red blood cell sedimentation rate increased | 17.74 | 12.68 | 11 | 62103 | 78291 | 110448894 |
| Liver disorder | 17.73 | 12.68 | 33 | 62081 | 142210 | 110384975 |
| Peripheral swelling | 17.67 | 12.68 | 322 | 61792 | 403712 | 110123473 |
| Dialysis | 17.64 | 12.68 | 36 | 62078 | 19583 | 110507602 |
| Nitritoid reaction | 17.64 | 12.68 | 4 | 62110 | 28 | 110527157 |
| Shock | 17.53 | 12.68 | 68 | 62046 | 53520 | 110473665 |
| Therapeutic response decreased | 17.50 | 12.68 | 17 | 62097 | 96482 | 110430703 |
| Cerebral hypoperfusion | 17.29 | 12.68 | 9 | 62105 | 905 | 110526280 |
| Vascular stent thrombosis | 17.12 | 12.68 | 16 | 62098 | 4145 | 110523040 |
| Back injury | 17.08 | 12.68 | 3 | 62111 | 47396 | 110479789 |
| Myopathy | 17.02 | 12.68 | 41 | 62073 | 24919 | 110502266 |
| Excessive cerumen production | 16.89 | 12.68 | 9 | 62105 | 949 | 110526236 |
| Drug dependence | 16.80 | 12.68 | 64 | 62050 | 49956 | 110477229 |
| Hypotonia | 16.73 | 12.68 | 31 | 62083 | 15714 | 110511471 |
| Tachyphylaxis | 16.73 | 12.68 | 7 | 62107 | 428 | 110526757 |
| Vasodilatation | 16.58 | 12.68 | 15 | 62099 | 3729 | 110523456 |
| Oxygen saturation decreased | 16.57 | 12.68 | 40 | 62074 | 156942 | 110370243 |
| Motor dysfunction | 16.55 | 12.68 | 40 | 62074 | 24366 | 110502819 |
| Linear IgA disease | 16.39 | 12.68 | 16 | 62098 | 4373 | 110522812 |
| Ventricular extrasystoles | 16.32 | 12.68 | 38 | 62076 | 22603 | 110504582 |
| Conjunctival discolouration | 16.24 | 12.68 | 5 | 62109 | 124 | 110527061 |
| Corneal abrasion | 16.16 | 12.68 | 10 | 62104 | 1399 | 110525786 |
| Intestinal ischaemia | 16.13 | 12.68 | 31 | 62083 | 16148 | 110511037 |
| Circulatory collapse | 16.11 | 12.68 | 57 | 62057 | 42936 | 110484249 |
| Musculoskeletal pain | 16.07 | 12.68 | 51 | 62063 | 182972 | 110344213 |
| Incorrect route of product administration | 15.96 | 12.68 | 8 | 62106 | 64053 | 110463132 |
| Atrioventricular block complete | 15.92 | 12.68 | 35 | 62079 | 20047 | 110507138 |
| Nodal rhythm | 15.72 | 12.68 | 14 | 62100 | 3409 | 110523776 |
| Glomerular filtration rate abnormal | 15.66 | 12.68 | 12 | 62102 | 2371 | 110524814 |
| Micturition disorder | 15.48 | 12.68 | 16 | 62098 | 4682 | 110522503 |
| Duodenal ulcer | 15.46 | 12.68 | 34 | 62080 | 19480 | 110507705 |
| Labelled drug-drug interaction issue | 15.41 | 12.68 | 15 | 62099 | 4086 | 110523099 |
| Hypercholesterolaemia | 15.35 | 12.68 | 17 | 62097 | 90820 | 110436365 |
| Peptic ulcer | 15.12 | 12.68 | 20 | 62094 | 7599 | 110519586 |
| Anxiety | 15.08 | 12.68 | 275 | 61839 | 344803 | 110182382 |
| Bronchitis | 15.06 | 12.68 | 42 | 62072 | 156990 | 110370195 |
| Rectal haemorrhage | 15.02 | 12.68 | 117 | 61997 | 119716 | 110407469 |
| Nasal crusting | 14.93 | 12.68 | 8 | 62106 | 853 | 110526332 |
| Hyperthyroidism | 14.80 | 12.68 | 43 | 62071 | 29218 | 110497967 |
| Sudden cardiac death | 14.74 | 12.68 | 17 | 62097 | 5620 | 110521565 |
| Adverse event | 14.69 | 12.68 | 24 | 62090 | 108785 | 110418400 |
| Laryngitis | 14.61 | 12.68 | 3 | 62111 | 42408 | 110484777 |
| Insomnia | 14.60 | 12.68 | 284 | 61830 | 360306 | 110166879 |
| Septic arthritis staphylococcal | 14.59 | 12.68 | 8 | 62106 | 893 | 110526292 |
| Loss of personal independence in daily activities | 14.48 | 12.68 | 40 | 62074 | 149980 | 110377205 |
| Blood creatine phosphokinase increased | 14.45 | 12.68 | 80 | 62034 | 72997 | 110454188 |
| Nodal arrhythmia | 14.36 | 12.68 | 11 | 62103 | 2173 | 110525012 |
| Electrocardiogram QRS complex prolonged | 14.29 | 12.68 | 26 | 62088 | 12995 | 110514190 |
| Neutrophil count decreased | 14.26 | 12.68 | 29 | 62085 | 120912 | 110406273 |
| Oliguria | 14.21 | 12.68 | 32 | 62082 | 18625 | 110508560 |
| Pancytopenia | 14.14 | 12.68 | 65 | 62049 | 209548 | 110317637 |
| Ventricular fibrillation | 13.99 | 12.68 | 53 | 62061 | 41260 | 110485925 |
| Ear infection | 13.96 | 12.68 | 9 | 62105 | 62723 | 110464462 |
| Muscle rigidity | 13.81 | 12.68 | 37 | 62077 | 23994 | 110503191 |
| Therapy non-responder | 13.70 | 12.68 | 44 | 62070 | 157263 | 110369922 |
| Stress | 13.52 | 12.68 | 24 | 62090 | 105324 | 110421861 |
| Lymphopenia | 13.51 | 12.68 | 3 | 62111 | 40167 | 110487018 |
| Peripheral arterial occlusive disease | 13.48 | 12.68 | 21 | 62093 | 9259 | 110517926 |
| Gait inability | 13.43 | 12.68 | 36 | 62078 | 136340 | 110390845 |
| Leukopenia | 13.39 | 12.68 | 41 | 62073 | 148750 | 110378435 |
| Nail disorder | 13.32 | 12.68 | 8 | 62106 | 57927 | 110469258 |
| Sideroblastic anaemia | 13.27 | 12.68 | 6 | 62108 | 443 | 110526742 |
| Osteoporosis | 13.17 | 12.68 | 89 | 62025 | 87063 | 110440122 |
| Lupus myocarditis | 13.16 | 12.68 | 4 | 62110 | 95 | 110527090 |
| Acid base balance abnormal | 12.87 | 12.68 | 6 | 62108 | 475 | 110526710 |
| Gastritis | 12.85 | 12.68 | 62 | 62052 | 53637 | 110473548 |
| Left ventricular failure | 12.83 | 12.68 | 23 | 62091 | 11366 | 110515819 |
| Product administration error | 12.81 | 12.68 | 48 | 62066 | 37169 | 110490016 |
| Epilepsy | 12.71 | 12.68 | 23 | 62091 | 100186 | 110426999 |
| Pneumonectomy | 12.71 | 12.68 | 4 | 62110 | 107 | 110527078 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C01DA14 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY VASODILATORS USED IN CARDIAC DISEASES Organic nitrates |
| FDA CS | M0014874 | Nitrates |
| FDA PE | N0000009909 | Vasodilation |
| FDA EPC | N0000175415 | Nitrate Vasodilator |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D014665 | Vasodilator Agents |
| MeSH PA | D020030 | Nitric Oxide Donors |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
| CHEBI has role | CHEBI:35620 | vasodilator agent |
| CHEBI has role | CHEBI:35674 | antihypertensive agent |
| CHEBI has role | CHEBI:50566 | nitric oxide donor |
Related Drugs by ATC class:
C01DA Organic nitrates 7 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Angina pectoris | indication | 194828000 | |
| Angina Pectoris Prevention | indication | ||
| Chronic heart failure | off-label use | 48447003 | |
| Prevention of Bleeding Esophageal Varices | off-label use | ||
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Low blood pressure | contraindication | 45007003 | |
| Injury of head | contraindication | 82271004 | |
| Increased intestinal motility | contraindication | 102624003 | |
| Hypertrophic cardiomyopathy | contraindication | 233873004 | DOID:11984 |
| Anemia | contraindication | 271737000 | DOID:2355 |
| Cerebral hemorrhage | contraindication | 274100004 | |
| Malabsorption States | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Soluble guanylate cyclase | Enzyme | ACTIVATOR | CHEMBL | CHEMBL | |||||
| Atrial natriuretic peptide receptor 1 | Enzyme | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| 4020224 | VUID |
| N0000179163 | NUI |
| D00630 | KEGG_DRUG |
| 4020224 | VANDF |
| C0064079 | UMLSCUI |
| CHEBI:6062 | CHEBI |
| CHEMBL1311 | ChEMBL_ID |
| DB01020 | DRUGBANK_ID |
| 27661 | PUBCHEM_CID |
| 7052 | IUPHAR_LIGAND_ID |
| C030397 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5177 | INN_ID |
| LX1OH63030 | UNII |
| 28004 | RXNORM |
| 4935 | MMSL |
| 6257 | MMSL |
| d00269 | MMSL |
| 003639 | NDDF |
| 108484003 | SNOMEDCT_US |
| 386854005 | SNOMEDCT_US |
| LX1OH63030 | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Isosorbide Mononitrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2620 | TABLET | 20 mg | ORAL | ANDA | 21 sections |
| Isosorbide Mononitrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2631 | TABLET | 10 mg | ORAL | ANDA | 21 sections |
| ISOSORBIDE MONONITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7767 | TABLET, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 12 sections |
| ISOSORBIDE MONONITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7768 | TABLET, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 12 sections |
| ISOSORBIDE MONONITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6449 | TABLET, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 12 sections |
| ISOSORBIDE MONONITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6450 | TABLET, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 12 sections |
| ISOSORBIDE MONONITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-243 | TABLET, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 21 sections |
| ISOSORBIDE MONONITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-104 | TABLET, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 12 sections |
| ISOSORBIDE MONONITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-105 | TABLET, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 12 sections |
| ISOSORBIDE MONONITRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-106 | TABLET, EXTENDED RELEASE | 120 mg | ORAL | ANDA | 12 sections |
| isosorbide mononitrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-396 | TABLET, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 23 sections |
| isosorbide mononitrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-397 | TABLET, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 23 sections |
| isosorbide mononitrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-398 | TABLET, EXTENDED RELEASE | 120 mg | ORAL | ANDA | 23 sections |
| isosorbide mononitrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-575 | TABLET, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 23 sections |
| isosorbide mononitrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-777 | TABLET, EXTENDED RELEASE | 120 mg | ORAL | ANDA | 23 sections |
| isosorbide mononitrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-837 | TABLET, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 23 sections |
| Isosorbide Mononitrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-178 | TABLET, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 12 sections |
| Isosorbide Mononitrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-519 | TABLET, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 12 sections |
| Isosorbide Mononitrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-628 | TABLET, EXTENDED RELEASE | 120 mg | ORAL | ANDA | 12 sections |
| Isosorbide Mononitrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42677-305 | TABLET, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 11 sections |
| Isosorbide Mononitrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42677-306 | TABLET, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 11 sections |
| Isosorbide Mononitrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42677-307 | TABLET, EXTENDED RELEASE | 120 mg | ORAL | ANDA | 11 sections |
| Isosorbide Mononitrate | Human Prescription Drug Label | 1 | 42799-958 | TABLET, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 20 sections |
| Isosorbide Mononitrate | Human Prescription Drug Label | 1 | 42799-959 | TABLET, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 20 sections |
| Isosorbide Mononitrate | Human Prescription Drug Label | 1 | 42799-960 | TABLET, EXTENDED RELEASE | 120 mg | ORAL | ANDA | 20 sections |
| isosorbide mononitrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43353-917 | TABLET, EXTENDED RELEASE | 120 mg | ORAL | ANDA | 23 sections |
| isosorbide mononitrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0787 | TABLET, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 23 sections |
| Isosorbide Mononitrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-1963 | TABLET, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 25 sections |
| isosorbide mononitrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-2077 | TABLET, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 23 sections |
| Isosorbide Mononitrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-2554 | TABLET, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 25 sections |