glyceryl trinitrate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
NO2 - derivatives 1952 55-63-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nitroglycerin
  • nitroglycerine
  • nitroglycerol
  • propanetriol trinitrate
  • trinitroglycerin
  • trinitroglycerol
  • glyceryl trinitrate
A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
  • Molecular weight: 227.09
  • Formula: C3H5N3O9
  • CLOGP: -5.76
  • LIPINSKI: 1
  • HAC: 12
  • HDO: 0
  • TPSA: 165.15
  • ALOGS: -3.05
  • ROTB: 8

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
5 mg O
2.50 mg oral aerosol
2.50 mg SL
5 mg TD

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.80 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.64 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 1 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance) 194.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.40 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 4.50 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
May 28, 1981 FDA FOUGERA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 826.35 10.33 795 57146 96733 46531388
Coronary artery disease 389.62 10.33 328 57613 33424 46594697
Angina pectoris 350.53 10.33 280 57661 26495 46601626
Cardiac failure congestive 338.72 10.33 489 57452 91261 46536860
Acute myocardial infarction 325.43 10.33 289 57652 31635 46596486
Chest pain 319.69 10.33 687 57254 175637 46452484
Orthostatic hypotension 210.07 10.33 202 57739 24456 46603665
Angina unstable 208.37 10.33 125 57816 7423 46620698
Sedation complication 148.67 10.33 78 57863 3567 46624554
Renal failure 144.29 10.33 386 57555 113208 46514913
Coronary arterial stent insertion 130.65 10.33 66 57875 2787 46625334
Renal injury 127.41 10.33 101 57840 9440 46618681
Creatinine renal clearance decreased 125.41 10.33 88 57853 6832 46621289
Acute coronary syndrome 119.37 10.33 100 57841 10104 46618017
Fear 114.75 10.33 120 57821 16052 46612069
Rheumatoid arthritis 110.69 10.33 82 57859 240133 46387988
Injury 101.59 10.33 190 57751 43837 46584284
Hypotension 97.09 10.33 555 57386 232034 46396087
Bradycardia 96.22 10.33 237 57704 66061 46562060
Anhedonia 90.52 10.33 86 57855 10249 46617872
Gastrointestinal haemorrhage 90.29 10.33 255 57686 77118 46551003
Off label use 87.40 10.33 216 57725 379625 46248496
Drug ineffective 85.32 10.33 494 57447 677344 45950777
Sedation 82.74 10.33 121 57820 22789 46605332
Cerebrovascular accident 82.16 10.33 294 57647 100745 46527376
Blood calcium decreased 81.60 10.33 99 57842 15574 46612547
Emotional distress 80.36 10.33 140 57801 30567 46597554
Coronary artery occlusion 77.86 10.33 71 57870 8031 46620090
Fall 73.16 10.33 675 57266 328422 46299699
Labile blood pressure 71.04 10.33 37 57904 1666 46626455
Myocardial ischaemia 68.77 10.33 82 57859 12667 46615454
Balance disorder 66.04 10.33 203 57738 64318 46563803
Treatment failure 66.04 10.33 17 57924 93070 46535051
Cognitive disorder 63.48 10.33 141 57800 36742 46591379
Peripheral vascular disorder 62.63 10.33 55 57886 5922 46622199
Transient ischaemic attack 60.71 10.33 134 57807 34769 46593352
Cardiac disorder 60.68 10.33 154 57787 43704 46584417
Hyperkalaemia 59.99 10.33 168 57773 50541 46577580
Syncope 58.91 10.33 272 57669 104531 46523590
Atrial fibrillation 56.13 10.33 266 57675 103324 46524797
Febrile neutropenia 55.41 10.33 24 57917 94603 46533518
Unevaluable event 52.68 10.33 151 57790 46024 46582097
Neutropenia 50.55 10.33 62 57879 143142 46484979
Drug abuse 50.22 10.33 9 57932 63399 46564722
Pyrexia 48.17 10.33 246 57695 348556 46279565
Depressed level of consciousness 48.05 10.33 149 57792 47420 46580701
Maternal exposure during pregnancy 47.16 10.33 35 57906 102514 46525607
Cardiac failure 46.78 10.33 210 57731 79738 46548383
Renal impairment 46.28 10.33 199 57742 74173 46553948
Contraindicated product administered 45.66 10.33 21 57920 79926 46548195
Abortion spontaneous 42.51 10.33 3 57938 43643 46584478
Oesophageal spasm 42.48 10.33 28 57913 1961 46626160
Alopecia 42.43 10.33 86 57855 162328 46465793
Ischaemic cardiomyopathy 42.26 10.33 31 57910 2579 46625542
Acute kidney injury 39.54 10.33 457 57484 235398 46392723
Arteriospasm coronary 39.31 10.33 34 57907 3587 46624534
Troponin increased 38.47 10.33 48 57893 7768 46620353
Infusion related reaction 37.66 10.33 42 57899 101166 46526955
Hypoglycaemia 37.40 10.33 150 57791 54199 46573922
Coronary artery bypass 37.26 10.33 28 57913 2417 46625704
Intentional overdose 37.18 10.33 17 57924 64927 46563194
Chronic obstructive pulmonary disease 34.92 10.33 153 57788 57480 46570641
White blood cell count decreased 34.18 10.33 54 57887 112177 46515944
Bursitis infective 33.80 10.33 20 57921 1157 46626964
Arteriosclerosis coronary artery 33.77 10.33 46 57895 8110 46620011
Drug intolerance 33.41 10.33 84 57857 146965 46481156
Abdominal discomfort 33.08 10.33 88 57853 151077 46477044
Systemic lupus erythematosus 32.98 10.33 20 57921 65160 46562961
Pulmonary oedema 32.75 10.33 138 57803 50967 46577154
Injection site pain 32.21 10.33 52 57889 107100 46521021
Suicide attempt 32.14 10.33 14 57927 55022 46573099
Coronary artery stenosis 31.70 10.33 34 57907 4679 46623442
Cardiac arrest 31.45 10.33 206 57735 90193 46537928
Sinus arrest 31.33 10.33 22 57919 1709 46626412
Hyponatraemia 31.15 10.33 224 57717 101108 46527013
Prinzmetal angina 30.34 10.33 16 57925 739 46627382
Hepatic ischaemia 30.09 10.33 14 57927 492 46627629
Product dose omission issue 29.86 10.33 108 57833 168412 46459709
Cardiac murmur 29.83 10.33 52 57889 11352 46616769
Completed suicide 29.66 10.33 88 57853 145832 46482289
Dyspnoea 29.38 10.33 842 57099 514706 46113415
Sinus node dysfunction 28.95 10.33 31 57910 4258 46623863
Injection site pruritus 28.67 10.33 7 57934 39736 46588385
Product solubility abnormal 28.53 10.33 16 57925 836 46627285
Injection site reaction 28.21 10.33 12 57929 47837 46580284
Exposure during pregnancy 27.65 10.33 58 57883 108154 46519967
Injection site erythema 27.56 10.33 31 57910 74396 46553725
Muscle relaxant therapy 27.42 10.33 9 57932 120 46628001
Hand deformity 27.17 10.33 5 57936 34569 46593552
Lower gastrointestinal haemorrhage 26.91 10.33 39 57902 7281 46620840
Hyperkeratosis 26.57 10.33 32 57909 4993 46623128
Malignant neoplasm progression 26.35 10.33 25 57916 64901 46563220
Hepatic enzyme increased 26.20 10.33 38 57903 81749 46546372
Stress 26.18 10.33 130 57811 51421 46576700
Disease progression 25.88 10.33 46 57895 91254 46536867
Product use issue 25.66 10.33 49 57892 94595 46533526
Fear of eating 24.98 10.33 11 57930 339 46627782
Condition aggravated 24.86 10.33 190 57751 244862 46383259
Haemorrhage 24.84 10.33 134 57807 54735 46573386
Nasopharyngitis 24.52 10.33 103 57838 153895 46474226
International normalised ratio increased 24.36 10.33 119 57822 46764 46581357
Confusional state 23.78 10.33 303 57638 159589 46468532
Psoriasis 23.76 10.33 38 57903 78566 46549555
Hyperlipidaemia 23.48 10.33 63 57878 18476 46609645
Glossodynia 23.32 10.33 13 57928 44360 46583761
Left ventricular dysfunction 23.32 10.33 44 57897 10211 46617910
Coronary artery dissection 23.22 10.33 13 57928 677 46627444
Anxiety 23.04 10.33 335 57606 181622 46446499
Sinus bradycardia 22.93 10.33 52 57889 13730 46614391
Arthralgia 22.84 10.33 317 57624 364286 46263835
Infection 22.75 10.33 87 57854 133505 46494616
Angioplasty 22.69 10.33 16 57925 1251 46626870
Drug interaction 22.68 10.33 366 57575 202728 46425393
Haematemesis 22.68 10.33 83 57858 28723 46599398
Autonomic dysreflexia 22.65 10.33 9 57932 213 46627908
Mucosal inflammation 22.62 10.33 10 57931 38966 46589155
Joint swelling 22.37 10.33 118 57823 165955 46462166
Presyncope 22.32 10.33 74 57867 24380 46603741
Acute pulmonary oedema 21.98 10.33 37 57904 7854 46620267
Rash 21.97 10.33 311 57630 356201 46271920
Melaena 21.85 10.33 80 57861 27692 46600429
Diarrhoea 21.75 10.33 529 57412 559073 46069048
Cardiomegaly 21.73 10.33 59 57882 17423 46610698
Hepatorenal syndrome 21.73 10.33 18 57923 1790 46626331
Percutaneous coronary intervention 21.72 10.33 8 57933 153 46627968
Arterial occlusive disease 21.28 10.33 28 57913 4776 46623345
Arthropathy 21.13 10.33 46 57895 84654 46543467
Blood loss anaemia 21.07 10.33 38 57903 8519 46619602
Dermatitis bullous 20.19 10.33 35 57906 7608 46620513
Pituitary apoplexy 20.16 10.33 7 57934 112 46628009
Hypertension 19.78 10.33 348 57593 196008 46432113
Neutrophil count decreased 19.72 10.33 15 57926 43411 46584710
Chronic kidney disease 19.31 10.33 101 57840 40770 46587351
Atrioventricular block 19.06 10.33 32 57909 6779 46621342
Product use in unapproved indication 18.65 10.33 54 57887 90219 46537902
Colitis microscopic 18.61 10.33 31 57910 6525 46621596
Hypovolaemia 18.37 10.33 39 57902 9849 46618272
Therapeutic product effect decreased 18.12 10.33 48 57893 82553 46545568
Synovitis 18.01 10.33 30 57911 61045 46567076
Laryngotracheal oedema 17.99 10.33 5 57936 36 46628085
Ventricular tachycardia 17.92 10.33 54 57887 16913 46611208
Fatigue 17.90 10.33 598 57343 608099 46020022
Bundle branch block left 17.82 10.33 30 57911 6369 46621752
Duodenal ulcer 17.70 10.33 32 57909 7186 46620935
Device dislocation 17.47 10.33 3 57938 21799 46606322
Psoriatic arthropathy 17.26 10.33 12 57929 36367 46591754
Mitral valve incompetence 17.16 10.33 57 57884 18795 46609326
Leukopenia 17.14 10.33 37 57904 68306 46559815
Coronary artery reocclusion 17.11 10.33 5 57936 44 46628077
Electrocardiogram ST segment elevation 17.09 10.33 22 57919 3673 46624448
Silent myocardial infarction 16.81 10.33 9 57932 429 46627692
Coronary artery restenosis 16.79 10.33 9 57932 430 46627691
Sputum discoloured 16.77 10.33 44 57897 12734 46615387
Reperfusion arrhythmia 16.63 10.33 5 57936 49 46628072
Bone marrow failure 16.62 10.33 8 57933 29661 46598460
Lip swelling 16.60 10.33 69 57872 25326 46602795
Ventricular extrasystoles 16.51 10.33 40 57901 11023 46617098
Left ventricular end-diastolic pressure increased 16.47 10.33 8 57933 310 46627811
Laryngospasm 16.36 10.33 19 57922 2854 46625267
Rectal haemorrhage 16.36 10.33 92 57849 38163 46589958
Multiple organ dysfunction syndrome 16.28 10.33 115 57826 51595 46576526
Sinusitis 15.94 10.33 95 57846 129673 46498448
Swollen tongue 15.76 10.33 75 57866 29157 46598964
Generalised tonic-clonic seizure 15.67 10.33 7 57934 27115 46601006
Discoloured vomit 15.62 10.33 9 57932 495 46627626
Pancytopenia 15.39 10.33 54 57887 85004 46543117
Oedema peripheral 15.35 10.33 281 57660 159425 46468696
C-reactive protein increased 15.30 10.33 31 57910 58559 46569562
Bacteriuria 15.08 10.33 10 57931 707 46627414
Troponin T increased 14.97 10.33 11 57930 918 46627203
Neuropathy peripheral 14.95 10.33 60 57881 90833 46537288
Cardiac failure chronic 14.78 10.33 20 57921 3504 46624617
Injection site swelling 14.70 10.33 17 57924 40310 46587811
Pruritus 14.69 10.33 212 57729 242140 46385981
Intentional product use issue 14.59 10.33 27 57914 52753 46575368
Coronary ostial stenosis 14.57 10.33 5 57936 77 46628044
Herpes zoster 14.46 10.33 40 57901 67832 46560289
Erythema 14.34 10.33 111 57830 142709 46485412
Subdural haematoma 14.33 10.33 42 57899 12955 46615166
Heart injury 14.19 10.33 12 57929 1227 46626894
Catheterisation cardiac 14.07 10.33 21 57920 4026 46624095
Headache 14.02 10.33 470 57471 477882 46150239
Palmar-plantar erythrodysaesthesia syndrome 13.99 10.33 4 57937 20447 46607674
Haematoma 13.86 10.33 77 57864 31795 46596326
Ascites 13.80 10.33 15 57926 36569 46591552
Peripheral ischaemia 13.54 10.33 22 57919 4537 46623584
Musculoskeletal stiffness 13.53 10.33 69 57872 97924 46530197
Device issue 13.50 10.33 4 57937 19976 46608145
Cytomegalovirus infection 13.47 10.33 3 57938 18141 46609980
Acne 13.44 10.33 4 57937 19915 46608206
Arteriosclerosis 13.27 10.33 34 57907 9699 46618422
Mobility decreased 13.24 10.33 124 57817 60470 46567651
Oesophageal pain 13.13 10.33 16 57925 2527 46625594
Dyspnoea exertional 13.11 10.33 107 57834 50182 46577939
Vascular pseudoaneurysm 13.08 10.33 12 57929 1368 46626753
Systolic anterior motion of mitral valve 12.93 10.33 3 57938 9 46628112
Gastric haemorrhage 12.92 10.33 25 57916 5909 46622212
Finger amputation 12.69 10.33 8 57933 519 46627602
Ischaemia 12.66 10.33 21 57920 4403 46623718
Non-cardiac chest pain 12.50 10.33 25 57916 6053 46622068
Swelling 12.39 10.33 97 57844 124414 46503707
Knee arthroplasty 12.34 10.33 7 57934 23658 46604463
Atrioventricular block second degree 12.20 10.33 19 57922 3780 46624341
Suicidal ideation 12.18 10.33 33 57908 56349 46571772
Femur fracture 12.03 10.33 17 57924 36980 46591141
Therapeutic response decreased 11.99 10.33 22 57919 43123 46584998
Inappropriate schedule of product administration 11.94 10.33 41 57900 64972 46563149
Discomfort 11.93 10.33 25 57916 46645 46581476
Vascular graft 11.91 10.33 9 57932 783 46627338
Periorbital haematoma 11.90 10.33 9 57932 784 46627337
Arterial intramural haematoma 11.89 10.33 3 57938 14 46628107
Arteriogram coronary abnormal 11.89 10.33 3 57938 14 46628107
Cardiogenic shock 11.89 10.33 46 57895 16338 46611783
No adverse event 11.87 10.33 15 57926 34216 46593905
Throat irritation 11.87 10.33 11 57930 28890 46599231
Mitral valve calcification 11.84 10.33 10 57931 1021 46627100
Essential hypertension 11.73 10.33 20 57921 4290 46623831
Stent placement 11.72 10.33 18 57923 3538 46624583
Medication error 11.70 10.33 72 57869 30839 46597282
Flushing 11.70 10.33 41 57900 64573 46563548
Lupus myocarditis 11.70 10.33 4 57937 61 46628060
Acquired epidermolysis bullosa 11.64 10.33 4 57937 62 46628059
Hospitalisation 11.63 10.33 40 57901 63345 46564776
Red blood cell sedimentation rate increased 11.61 10.33 7 57934 22882 46605239
Drug eruption 11.57 10.33 6 57935 21323 46606798
Reflux gastritis 11.57 10.33 9 57932 818 46627303
Cardiomyopathy 11.56 10.33 45 57896 16028 46612093
Hyperhidrosis 11.51 10.33 165 57776 89143 46538978
Nephrogenic systemic fibrosis 11.51 10.33 21 57920 4751 46623370
Constipation 11.46 10.33 290 57651 173807 46454314
Colitis ischaemic 11.42 10.33 33 57908 10099 46618022
Hypertensive heart disease 11.38 10.33 15 57926 2563 46625558
Platelet count decreased 11.37 10.33 75 57866 99949 46528172
Lethargy 11.32 10.33 105 57836 51066 46577055
Sepsis 11.30 10.33 111 57830 135903 46492218
Lymphadenopathy 11.28 10.33 15 57926 33473 46594648
Total lung capacity decreased 11.21 10.33 10 57931 1099 46627022
Multiple injuries 11.17 10.33 13 57928 1956 46626165
Breast cancer 11.12 10.33 25 57916 45493 46582628
Acute myeloid leukaemia 10.96 10.33 3 57938 15775 46612346
Electrocardiogram T wave abnormal 10.90 10.33 14 57927 2332 46625789
Nodal rhythm 10.83 10.33 12 57929 1713 46626408
Therapeutic product effect incomplete 10.81 10.33 55 57886 78098 46550023
Coronary artery thrombosis 10.79 10.33 10 57931 1155 46626966
Ventricular hypertrophy 10.78 10.33 18 57923 3796 46624325
Cardioactive drug level increased 10.70 10.33 13 57928 2046 46626075
Leg amputation 10.68 10.33 13 57928 2050 46626071
Patent ductus arteriosus 10.61 10.33 18 57923 3844 46624277
Coagulation time abnormal 10.56 10.33 4 57937 83 46628038
Stridor 10.47 10.33 16 57925 3131 46624990
Mental status changes 10.45 10.33 82 57859 38006 46590115
Hypoosmolar state 10.36 10.33 5 57936 191 46627930
Cardiac arrest neonatal 10.34 10.33 4 57937 88 46628033

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 884.59 10.88 1140 56010 124485 29770843
Chest pain 435.24 10.88 793 56357 116834 29778494
Coronary artery disease 405.91 10.88 487 56663 49225 29846103
Angina pectoris 393.16 10.88 375 56775 29143 29866185
Acute myocardial infarction 370.39 10.88 480 56670 52459 29842869
Cardiac failure congestive 316.78 10.88 573 56577 83834 29811494
Injury 212.73 10.88 234 56916 21497 29873831
Fear 209.19 10.88 170 56980 10655 29884673
Angina unstable 208.23 10.88 179 56971 12131 29883197
Coronary arterial stent insertion 178.55 10.88 107 57043 4087 29891241
Anhedonia 177.88 10.88 139 57011 8230 29887098
Renal injury 152.21 10.88 147 57003 11582 29883746
Emotional distress 146.08 10.88 165 56985 15600 29879728
Drug abuse 128.04 10.88 7 57143 82065 29813263
Stress 110.51 10.88 163 56987 20072 29875256
Hypotension 108.12 10.88 703 56447 199862 29695466
Bradycardia 103.28 10.88 317 56833 65209 29830119
Product solubility abnormal 102.65 10.88 39 57111 517 29894811
Unevaluable event 93.55 10.88 195 56955 31590 29863738
Ischaemic cardiomyopathy 87.55 10.88 82 57068 6215 29889113
Off label use 85.82 10.88 221 56929 249069 29646259
Syncope 85.05 10.88 354 56796 84549 29810779
Toxicity to various agents 77.68 10.88 137 57013 177046 29718282
Cardiac disorder 75.36 10.88 206 56944 39687 29855641
Anxiety 72.20 10.88 351 56799 89520 29805808
Myocardial ischaemia 71.79 10.88 123 57027 17194 29878134
Dizziness 70.36 10.88 622 56528 194287 29701041
Coronary artery bypass 69.43 10.88 66 57084 5096 29890232
Pyrexia 66.30 10.88 313 56837 294176 29601152
Presyncope 57.51 10.88 107 57043 15949 29879379
Completed suicide 57.48 10.88 63 57087 99429 29795899
Neutropenia 56.63 10.88 99 57051 128441 29766887
Acute coronary syndrome 55.72 10.88 96 57054 13477 29881851
Coronary artery occlusion 54.01 10.88 85 57065 11072 29884256
Ventricular extrasystoles 52.23 10.88 85 57065 11389 29883939
Ventricular fibrillation 51.88 10.88 99 57051 15039 29880289
Febrile neutropenia 49.93 10.88 79 57071 106614 29788714
Ventricular tachycardia 49.90 10.88 128 57022 23734 29871594
Foetal exposure during pregnancy 49.62 10.88 6 57144 36865 29858463
Cerebrovascular accident 47.50 10.88 297 56853 83180 29812148
Coronary artery stenosis 46.56 10.88 71 57079 8999 29886329
Product use in unapproved indication 45.57 10.88 44 57106 73649 29821679
Atrial fibrillation 44.73 10.88 356 56794 107768 29787560
Renal failure 43.59 10.88 406 56744 128560 29766768
Chronic obstructive pulmonary disease 43.55 10.88 189 56961 45937 29849391
Pain 40.88 10.88 506 56644 172135 29723193
Dyspnoea 38.76 10.88 869 56281 332426 29562902
Malignant neoplasm progression 38.29 10.88 49 57101 72238 29823090
Chest discomfort 36.73 10.88 178 56972 45302 29850026
Arteriosclerosis coronary artery 35.75 10.88 71 57079 11105 29884223
Gastrointestinal haemorrhage 35.17 10.88 276 56874 83170 29812158
C-reactive protein increased 33.13 10.88 21 57129 43452 29851876
International normalised ratio increased 31.08 10.88 176 56974 47563 29847765
Prinzmetal angina 30.24 10.88 20 57130 909 29894419
Diarrhoea 29.34 10.88 455 56695 333648 29561680
Drug reaction with eosinophilia and systemic symptoms 29.19 10.88 9 57141 28479 29866849
Therapeutic product effect incomplete 29.18 10.88 14 57136 33820 29861508
Cardiac failure 28.85 10.88 264 56886 83154 29812174
Leukopenia 27.78 10.88 40 57110 56119 29839209
Drug ineffective 27.74 10.88 470 56680 339917 29555411
Hepatic function abnormal 27.16 10.88 24 57126 41921 29853407
Cytomegalovirus infection 27.07 10.88 6 57144 23668 29871660
Troponin increased 26.82 10.88 55 57095 8802 29886526
Cerebral artery thrombosis 26.71 10.88 15 57135 506 29894822
Rash 26.64 10.88 236 56914 191653 29703675
Middle insomnia 26.59 10.88 43 57107 5730 29889598
Hyperlipidaemia 25.43 10.88 71 57079 13836 29881492
Base excess decreased 24.92 10.88 11 57139 218 29895110
Acute kidney injury 24.62 10.88 690 56460 273152 29622176
Electrocardiogram ST segment elevation 24.55 10.88 36 57114 4406 29890922
Mucosal inflammation 24.26 10.88 14 57136 30480 29864848
Orthostatic hypotension 23.97 10.88 100 57050 23879 29871449
Post procedural complication 23.58 10.88 62 57088 11664 29883664
Product dose omission issue 23.19 10.88 93 57057 91538 29803790
Vascular stent occlusion 22.99 10.88 9 57141 130 29895198
Coronary artery thrombosis 22.37 10.88 24 57126 2140 29893188
Neutrophil count decreased 22.24 10.88 29 57121 42425 29852903
Renal impairment 21.74 10.88 251 56899 83933 29811395
White blood cell count decreased 21.37 10.88 85 57065 83862 29811466
Brain scan abnormal 21.12 10.88 14 57136 639 29894689
Neuroleptic malignant syndrome 21.08 10.88 3 57147 16292 29879036
Infusion related reaction 20.95 10.88 28 57122 40536 29854792
Oxygen consumption decreased 20.79 10.88 9 57141 170 29895158
Bone marrow failure 20.57 10.88 16 57134 29769 29865559
Pulmonary oedema 20.51 10.88 149 57001 43826 29851502
Arteriosclerosis 20.50 10.88 56 57094 10777 29884551
Laryngeal haematoma 20.34 10.88 8 57142 117 29895211
Peripheral vascular disorder 20.23 10.88 36 57114 5183 29890145
Reperfusion arrhythmia 20.11 10.88 7 57143 71 29895257
Intentional product misuse 19.95 10.88 22 57128 34645 29860683
Orthopnoea 19.81 10.88 33 57117 4507 29890821
Overdose 19.25 10.88 89 57061 84248 29811080
Rectal haemorrhage 19.03 10.88 123 57027 34816 29860512
Cardiac arrest 18.94 10.88 265 56885 92585 29802743
Rheumatoid arthritis 18.78 10.88 31 57119 41166 29854162
Arteriospasm coronary 18.67 10.88 24 57126 2594 29892734
Circulatory collapse 18.44 10.88 82 57068 20132 29875196
Supraventricular tachycardia 18.35 10.88 52 57098 10220 29885108
Pneumocystis jirovecii pneumonia 18.29 10.88 5 57145 17115 29878213
International normalised ratio decreased 18.23 10.88 32 57118 4558 29890770
Post procedural haemorrhage 18.18 10.88 44 57106 7866 29887462
Blood loss anaemia 18.15 10.88 43 57107 7584 29887744
Sinus bradycardia 17.85 10.88 56 57094 11639 29883689
Treatment failure 17.84 10.88 24 57126 34655 29860673
Infection 17.46 10.88 83 57067 77991 29817337
Platelet count decreased 17.25 10.88 125 57025 106004 29789324
Cardiac arrest neonatal 17.09 10.88 5 57145 27 29895301
Discharge 17.06 10.88 7 57143 115 29895213
Stomatitis 17.04 10.88 28 57122 37251 29858077
Non-cardiac chest pain 16.80 10.88 29 57121 4075 29891253
Carotid artery stenosis 16.64 10.88 31 57119 4623 29890705
Alanine aminotransferase increased 16.59 10.88 79 57071 74197 29821131
Vascular graft 16.58 10.88 17 57133 1438 29893890
Mitral valve incompetence 16.33 10.88 59 57091 13175 29882153
Atrial flutter 16.23 10.88 62 57088 14219 29881109
Normochromic normocytic anaemia 16.19 10.88 28 57122 3942 29891386
Heart rate decreased 15.41 10.88 80 57070 20914 29874414
Gastrointestinal tract irritation 15.25 10.88 8 57142 235 29895093
Coagulation time prolonged 15.13 10.88 15 57135 1219 29894109
Ventricular dysfunction 15.13 10.88 26 57124 3641 29891687
Death 15.12 10.88 544 56606 356739 29538589
Vascular graft occlusion 15.04 10.88 11 57139 589 29894739
Osteonecrosis 14.98 10.88 6 57144 16129 29879199
Cervicogenic headache 14.85 10.88 4 57146 15 29895313
Cardiac procedure complication 14.77 10.88 8 57142 251 29895077
Chronic kidney disease 14.75 10.88 123 57027 37715 29857613
Nerve degeneration 14.75 10.88 7 57143 165 29895163
Ecchymosis 14.69 10.88 36 57114 6486 29888842
Disease progression 14.51 10.88 91 57059 79783 29815545
Intentional overdose 14.03 10.88 37 57113 41444 29853884
Sepsis 13.95 10.88 196 56954 146199 29749129
Decreased appetite 13.83 10.88 202 56948 149708 29745620
Neurotoxicity 13.80 10.88 4 57146 13178 29882150
Multiple injuries 13.69 10.88 18 57132 1989 29893339
Seizure 13.68 10.88 121 57029 98354 29796974
Arterial spasm 13.45 10.88 6 57144 122 29895206
Interstitial lung disease 13.45 10.88 64 57086 60133 29835195
Acute myeloid leukaemia 13.31 10.88 9 57141 17997 29877331
Stent placement 13.28 10.88 28 57122 4568 29890760
Swollen tongue 13.17 10.88 55 57095 13137 29882191
Psychotic disorder 13.11 10.88 13 57137 21502 29873826
Hyperhidrosis 13.08 10.88 190 56960 66900 29828428
Poor quality product administered 13.02 10.88 16 57134 1653 29893675
Left ventricular enlargement 12.97 10.88 10 57140 580 29894748
Tricuspid valve incompetence 12.89 10.88 41 57109 8582 29886746
Generalised tonic-clonic seizure 12.88 10.88 11 57139 19540 29875788
Hypertrophy 12.86 10.88 8 57142 327 29895001
Hiatus hernia 12.77 10.88 36 57114 7054 29888274
Hepatocellular injury 12.73 10.88 18 57132 25453 29869875
Haematuria 12.62 10.88 136 57014 44698 29850630
Intentional self-injury 12.62 10.88 5 57145 13527 29881801
Cardiomegaly 12.59 10.88 58 57092 14451 29880877
Cold sweat 12.52 10.88 42 57108 9040 29886288
Morning glory syndrome 12.51 10.88 3 57147 6 29895322
Arrhythmia 12.50 10.88 107 57043 33062 29862266
Organ failure 12.46 10.88 18 57132 2173 29893155
Drug resistance 12.46 10.88 12 57138 20121 29875207
Acute pulmonary oedema 12.42 10.88 37 57113 7478 29887850
Myocardial necrosis marker increased 12.23 10.88 15 57135 1546 29893782
Brain natriuretic peptide increased 12.15 10.88 25 57125 4010 29891318
Ventricular asystole 12.10 10.88 6 57144 156 29895172
Coronary ostial stenosis 12.03 10.88 5 57145 85 29895243
Coronary artery restenosis 12.02 10.88 13 57137 1170 29894158
Mean cell haemoglobin decreased 11.89 10.88 13 57137 1184 29894144
Melaena 11.89 10.88 104 57046 32333 29862995
Hyperbilirubinaemia 11.82 10.88 9 57141 16933 29878395
Palmar-plantar erythrodysaesthesia syndrome 11.58 10.88 7 57143 14863 29880465
Respiratory arrest 11.57 10.88 24 57126 29234 29866094
Pneumonia 11.55 10.88 521 56629 333785 29561543
Ureteral disorder 11.41 10.88 6 57144 177 29895151
Transaminases increased 11.31 10.88 17 57133 23440 29871888
Haemorrhage 11.27 10.88 136 57014 45943 29849385
Blood count abnormal 11.18 10.88 48 57102 11604 29883724
Ventricular arrhythmia 11.11 10.88 25 57125 4263 29891065
Injection site pain 11.06 10.88 26 57124 30284 29865044
Myocardial depression 11.04 10.88 4 57146 46 29895282
Blood creatine phosphokinase MB increased 11.02 10.88 16 57134 1940 29893388
Hyperkalaemia 10.98 10.88 182 56968 65828 29829500
Product complaint 10.97 10.88 30 57120 5776 29889552

Pharmacologic Action:

SourceCodeDescription
ATC C01DA02 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
VASODILATORS USED IN CARDIAC DISEASES
Organic nitrates
ATC C01DA52 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
VASODILATORS USED IN CARDIAC DISEASES
Organic nitrates
ATC C05AE01 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Muscle relaxants
FDA CS M0014874 Nitrates
FDA PE N0000009909 Vasodilation
FDA EPC N0000175415 Nitrate Vasodilator
MeSH PA D002317 Cardiovascular Agents
MeSH PA D053834 Explosive Agents
MeSH PA D014665 Vasodilator Agents
CHEBI has role CHEBI:35620 vasodilator
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:50266 prodrugs
CHEBI has role CHEBI:50566 nitric oxide releasing agent
CHEBI has role CHEBI:51371 muscle relaxants
CHEBI has role CHEBI:63490 explosive material
CHEBI has role CHEBI:66993 anti-contraction drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Angina pectoris indication 194828000
Left ventricular cardiac dysfunction indication 429589006
Perioperative hypertension indication 434711000124103
Angina Pectoris Prevention indication
Myocardial infarction off-label use 22298006 DOID:5844
Anal fissure off-label use 30037006
Decompensated cardiac failure off-label use 195111005
Extravasation injury off-label use 371100002
Acute coronary syndrome off-label use 394659003
Hypertensive urgency off-label use 443482000
Hypovolemia contraindication 28560003
Cardiac tamponade contraindication 35304003 DOID:115
Methemoglobinemia contraindication 38959009 DOID:10783
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Injury of head contraindication 82271004
Constrictive pericarditis contraindication 85598007 DOID:11481
Hypertrophic cardiomyopathy contraindication 233873004 DOID:11984
Anemia contraindication 271737000 DOID:2355
Cerebral hemorrhage contraindication 274100004
Restrictive cardiomyopathy contraindication 415295002 DOID:397

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Soluble guanylate cyclase Enzyme ACTIVATOR CHEMBL CHEMBL
Atrial natriuretic peptide receptor 1 Enzyme WOMBAT-PK

External reference:

IDSource
4017525 VUID
N0000145909 NUI
D00515 KEGG_DRUG
4017525 VANDF
C0017887 UMLSCUI
CHEBI:28787 CHEBI
TNG PDB_CHEM_ID
CHEMBL730 ChEMBL_ID
DB00727 DRUGBANK_ID
D005996 MESH_DESCRIPTOR_UI
7053 IUPHAR_LIGAND_ID
G59M7S0WS3 UNII
4510 PUBCHEM_CID
4917 RXNORM
2324 MMSL
5183 MMSL
d00321 MMSL
000683 NDDF
387404004 SNOMEDCT_US
71759000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Nitrostat HUMAN PRESCRIPTION DRUG LABEL 1 0071-0417 TABLET 0.30 mg SUBLINGUAL NDA 26 sections
Nitrostat HUMAN PRESCRIPTION DRUG LABEL 1 0071-0418 TABLET 0.40 mg SUBLINGUAL NDA 26 sections
Nitrostat HUMAN PRESCRIPTION DRUG LABEL 1 0071-0419 TABLET 0.60 mg SUBLINGUAL NDA 26 sections
Cyclease Menopause HUMAN OTC DRUG LABEL 5 0220-9082 TABLET 4 [hp_C] ORAL unapproved homeopathic 10 sections
NITRO-BID HUMAN PRESCRIPTION DRUG LABEL 1 0281-0326 OINTMENT 20 mg TOPICAL ANDA 21 sections
Nitroglycerin In Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0338-1047 INJECTION 10 mg INTRAVENOUS NDA 20 sections
Nitroglycerin In Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0338-1049 INJECTION 20 mg INTRAVENOUS NDA 20 sections
Nitroglycerin In Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0338-1051 INJECTION 40 mg INTRAVENOUS NDA 20 sections
Nitroglycerin HUMAN PRESCRIPTION DRUG LABEL 1 0378-9102 PATCH 0.10 mg TRANSDERMAL ANDA 21 sections
Nitroglycerin HUMAN PRESCRIPTION DRUG LABEL 1 0378-9104 PATCH 0.20 mg TRANSDERMAL ANDA 21 sections
Nitroglycerin HUMAN PRESCRIPTION DRUG LABEL 1 0378-9112 PATCH 0.40 mg TRANSDERMAL ANDA 21 sections
Nitroglycerin HUMAN PRESCRIPTION DRUG LABEL 1 0378-9116 PATCH 0.60 mg TRANSDERMAL ANDA 21 sections
Nitroglycerin HUMAN PRESCRIPTION DRUG LABEL 1 0517-4810 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 21 sections
Nitro-Time HUMAN PRESCRIPTION DRUG LABEL 1 0904-0643 CAPSULE 2.50 mg ORAL Unapproved drug other 22 sections
Nitro-Time HUMAN PRESCRIPTION DRUG LABEL 1 0904-0644 CAPSULE 6.50 mg ORAL Unapproved drug other 22 sections
Nitro-Time HUMAN PRESCRIPTION DRUG LABEL 1 0904-0647 CAPSULE 9 mg ORAL Unapproved drug other 22 sections
Nitroglycerin Transdermal System HUMAN PRESCRIPTION DRUG LABEL 1 0904-5495 PATCH 0.20 mg TRANSDERMAL ANDA 18 sections
Nitroglycerin Transdermal System HUMAN PRESCRIPTION DRUG LABEL 1 0904-5496 PATCH 0.40 mg TRANSDERMAL ANDA 18 sections
Nitroglycerin Transdermal System HUMAN PRESCRIPTION DRUG LABEL 1 0904-5497 PATCH 0.60 mg TRANSDERMAL ANDA 18 sections
Nitrostat HUMAN PRESCRIPTION DRUG LABEL 1 21695-450 TABLET 0.40 mg SUBLINGUAL NDA 23 sections
Nitroglycerin Slocaps HUMAN PRESCRIPTION DRUG LABEL 1 21695-635 CAPSULE 2.50 mg ORAL Unapproved drug other 19 sections
Nitroglycerin Slocaps HUMAN PRESCRIPTION DRUG LABEL 1 21695-636 CAPSULE 6.50 mg ORAL Unapproved drug other 19 sections
Nitroglycerin HUMAN PRESCRIPTION DRUG LABEL 1 21695-810 TABLET 0.40 mg ORAL Unapproved drug other 23 sections
NITROGLYCERIN LINGUAL HUMAN PRESCRIPTION DRUG LABEL 1 28595-120 SPRAY 400 ug ORAL NDA 26 sections
NITROLINGUAL HUMAN PRESCRIPTION DRUG LABEL 1 28595-550 SPRAY 400 ug ORAL NDA 26 sections
GONITRO HUMAN PRESCRIPTION DRUG LABEL 1 28595-705 POWDER 400 ug SUBLINGUAL NDA 26 sections
Minitran HUMAN PRESCRIPTION DRUG LABEL 1 29336-301 PATCH 2.50 mg TRANSDERMAL ANDA 21 sections
Minitran HUMAN PRESCRIPTION DRUG LABEL 1 29336-302 PATCH 5 mg TRANSDERMAL ANDA 21 sections
Minitran HUMAN PRESCRIPTION DRUG LABEL 1 29336-303 PATCH 10 mg TRANSDERMAL ANDA 21 sections
Minitran HUMAN PRESCRIPTION DRUG LABEL 1 29336-304 PATCH 15 mg TRANSDERMAL ANDA 21 sections