Stem definition | Drug id | CAS RN |
---|---|---|
NO2 - derivatives | 1952 | 55-63-0 |
Dose | Unit | Route |
---|---|---|
5 | mg | O |
2.50 | mg | oral aerosol |
2.50 | mg | SL |
5 | mg | TD |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.80 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 1.64 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 1 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
CL (Clearance) | 194.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.40 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 4.50 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
May 28, 1981 | FDA | FOUGERA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Myocardial infarction | 914.01 | 10.51 | 817 | 63606 | 88210 | 50452491 |
Orthostatic hypotension | 549.78 | 10.51 | 385 | 64038 | 29096 | 50511605 |
Sedation complication | 471.41 | 10.51 | 228 | 64195 | 8538 | 50532163 |
Creatinine renal clearance decreased | 450.05 | 10.51 | 244 | 64179 | 11637 | 50529064 |
Coronary artery disease | 423.17 | 10.51 | 330 | 64093 | 29396 | 50511305 |
Cardiac failure congestive | 377.54 | 10.51 | 500 | 63923 | 83882 | 50456819 |
Sedation | 355.91 | 10.51 | 302 | 64121 | 30308 | 50510393 |
Blood calcium decreased | 350.47 | 10.51 | 255 | 64168 | 20451 | 50520250 |
Acute myocardial infarction | 348.97 | 10.51 | 293 | 64130 | 28980 | 50511721 |
Angina pectoris | 341.17 | 10.51 | 276 | 64147 | 25912 | 50514789 |
Cognitive disorder | 300.49 | 10.51 | 324 | 64099 | 43799 | 50496902 |
Balance disorder | 277.45 | 10.51 | 393 | 64030 | 70197 | 50470504 |
Depressed level of consciousness | 249.56 | 10.51 | 319 | 64104 | 51634 | 50489067 |
Chest pain | 246.69 | 10.51 | 632 | 63791 | 176250 | 50364451 |
Hypotension | 239.16 | 10.51 | 750 | 63673 | 234719 | 50305982 |
Fall | 202.76 | 10.51 | 903 | 63520 | 334029 | 50206672 |
Angina unstable | 200.53 | 10.51 | 118 | 64305 | 6588 | 50534113 |
Renal failure | 161.02 | 10.51 | 393 | 64030 | 106240 | 50434461 |
Renal injury | 141.02 | 10.51 | 104 | 64319 | 8507 | 50532194 |
Coronary arterial stent insertion | 137.03 | 10.51 | 67 | 64356 | 2567 | 50538134 |
Drug ineffective | 135.33 | 10.51 | 562 | 63861 | 818771 | 49721930 |
Acute coronary syndrome | 124.58 | 10.51 | 100 | 64323 | 9274 | 50531427 |
Contraindicated product administered | 122.64 | 10.51 | 21 | 64402 | 148937 | 50391764 |
Gastrointestinal haemorrhage | 121.20 | 10.51 | 280 | 64143 | 73041 | 50467660 |
Fear | 120.96 | 10.51 | 119 | 64304 | 14430 | 50526271 |
Off label use | 119.09 | 10.51 | 268 | 64155 | 474158 | 50066543 |
Constipation | 114.49 | 10.51 | 504 | 63919 | 185204 | 50355497 |
Systemic lupus erythematosus | 113.21 | 10.51 | 21 | 64402 | 140601 | 50400100 |
Mobility decreased | 112.57 | 10.51 | 287 | 64136 | 79661 | 50461040 |
Treatment failure | 109.85 | 10.51 | 21 | 64402 | 137616 | 50403085 |
Alopecia | 108.00 | 10.51 | 92 | 64331 | 244955 | 50295746 |
Hand deformity | 106.48 | 10.51 | 5 | 64418 | 100194 | 50440507 |
Glossodynia | 102.72 | 10.51 | 13 | 64410 | 115556 | 50425145 |
Maternal exposure during pregnancy | 96.94 | 10.51 | 41 | 64382 | 159737 | 50380964 |
Injury | 96.93 | 10.51 | 201 | 64222 | 48724 | 50491977 |
Bradycardia | 95.63 | 10.51 | 236 | 64187 | 64190 | 50476511 |
Cerebrovascular accident | 93.43 | 10.51 | 299 | 64124 | 94381 | 50446320 |
Anhedonia | 92.70 | 10.51 | 85 | 64338 | 9439 | 50531262 |
Labile blood pressure | 91.71 | 10.51 | 44 | 64379 | 1616 | 50539085 |
Abdominal discomfort | 91.46 | 10.51 | 96 | 64327 | 231545 | 50309156 |
Drug intolerance | 89.70 | 10.51 | 88 | 64335 | 219016 | 50321685 |
Infusion related reaction | 88.63 | 10.51 | 53 | 64370 | 169504 | 50371197 |
Coronary artery occlusion | 87.09 | 10.51 | 74 | 64349 | 7429 | 50533272 |
Hyperkalaemia | 86.53 | 10.51 | 190 | 64233 | 47899 | 50492802 |
Emotional distress | 84.82 | 10.51 | 140 | 64283 | 28523 | 50512178 |
Arthropathy | 81.63 | 10.51 | 50 | 64373 | 157856 | 50382845 |
Rheumatoid arthritis | 78.76 | 10.51 | 85 | 64338 | 202465 | 50338236 |
Hepatic enzyme increased | 76.02 | 10.51 | 40 | 64383 | 137340 | 50403361 |
Myocardial ischaemia | 75.02 | 10.51 | 83 | 64340 | 11530 | 50529171 |
Joint swelling | 74.95 | 10.51 | 123 | 64300 | 245163 | 50295538 |
Synovitis | 73.19 | 10.51 | 33 | 64390 | 123832 | 50416869 |
Peripheral vascular disorder | 71.96 | 10.51 | 58 | 64365 | 5409 | 50535292 |
Transient ischaemic attack | 71.77 | 10.51 | 139 | 64284 | 32071 | 50508630 |
Atrial fibrillation | 64.78 | 10.51 | 279 | 64144 | 101466 | 50439235 |
Discomfort | 63.83 | 10.51 | 29 | 64394 | 108351 | 50432350 |
Therapeutic product effect decreased | 62.45 | 10.51 | 49 | 64374 | 136001 | 50404700 |
Product use issue | 62.33 | 10.51 | 59 | 64364 | 149416 | 50391285 |
Swelling | 61.08 | 10.51 | 101 | 64322 | 200771 | 50339930 |
Syncope | 59.21 | 10.51 | 274 | 64149 | 102728 | 50437973 |
Cardiac disorder | 59.12 | 10.51 | 153 | 64270 | 42826 | 50497875 |
Renal impairment | 57.32 | 10.51 | 219 | 64204 | 75442 | 50465259 |
Febrile neutropenia | 54.67 | 10.51 | 28 | 64395 | 97639 | 50443062 |
Unevaluable event | 54.37 | 10.51 | 155 | 64268 | 45911 | 50494790 |
Neutropenia | 54.33 | 10.51 | 65 | 64358 | 147900 | 50392801 |
Cardiac failure | 54.28 | 10.51 | 216 | 64207 | 75824 | 50464877 |
Pyrexia | 53.89 | 10.51 | 275 | 64148 | 379928 | 50160773 |
Pericarditis | 53.08 | 10.51 | 17 | 64406 | 78672 | 50462029 |
Ischaemic cardiomyopathy | 52.14 | 10.51 | 34 | 64389 | 2278 | 50538423 |
Chronic obstructive pulmonary disease | 50.19 | 10.51 | 166 | 64257 | 53269 | 50487432 |
Rash | 50.01 | 10.51 | 339 | 64084 | 437132 | 50103569 |
Coronary artery bypass | 49.96 | 10.51 | 33 | 64390 | 2260 | 50538441 |
Hepatic ischaemia | 49.19 | 10.51 | 21 | 64402 | 584 | 50540117 |
Infection | 48.90 | 10.51 | 91 | 64332 | 172863 | 50367838 |
Acute kidney injury | 47.96 | 10.51 | 472 | 63951 | 227586 | 50313115 |
Drug abuse | 45.92 | 10.51 | 10 | 64413 | 59836 | 50480865 |
Arthralgia | 45.27 | 10.51 | 350 | 64073 | 438352 | 50102349 |
Condition aggravated | 44.27 | 10.51 | 211 | 64212 | 296847 | 50243854 |
Helicobacter infection | 43.17 | 10.51 | 6 | 64417 | 49696 | 50491005 |
Troponin increased | 42.37 | 10.51 | 52 | 64371 | 8066 | 50532635 |
Hyponatraemia | 41.45 | 10.51 | 236 | 64187 | 95903 | 50444798 |
Hypersensitivity | 41.45 | 10.51 | 138 | 64285 | 215023 | 50325678 |
Cardiac arrest | 41.24 | 10.51 | 213 | 64210 | 83438 | 50457263 |
Duodenal ulcer perforation | 40.83 | 10.51 | 5 | 64418 | 45606 | 50495095 |
Pulmonary oedema | 39.00 | 10.51 | 144 | 64279 | 48794 | 50491907 |
Abortion spontaneous | 38.85 | 10.51 | 4 | 64419 | 41768 | 50498933 |
Hepatorenal syndrome | 37.77 | 10.51 | 25 | 64398 | 1718 | 50538983 |
Hypoglycaemia | 37.26 | 10.51 | 151 | 64272 | 53430 | 50487271 |
Arteriospasm coronary | 36.34 | 10.51 | 32 | 64391 | 3370 | 50537331 |
Muscle relaxant therapy | 35.99 | 10.51 | 12 | 64411 | 164 | 50540537 |
Nasopharyngitis | 35.62 | 10.51 | 126 | 64297 | 192801 | 50347900 |
Coronary artery stenosis | 35.49 | 10.51 | 35 | 64388 | 4254 | 50536447 |
Injection site pain | 35.44 | 10.51 | 54 | 64369 | 110970 | 50429731 |
White blood cell count decreased | 35.16 | 10.51 | 59 | 64364 | 116663 | 50424038 |
Intentional overdose | 34.85 | 10.51 | 18 | 64405 | 62486 | 50478215 |
Angioplasty | 34.70 | 10.51 | 21 | 64402 | 1234 | 50539467 |
Haematemesis | 34.39 | 10.51 | 95 | 64328 | 27630 | 50513071 |
Wound | 34.21 | 10.51 | 51 | 64372 | 105743 | 50434958 |
Prinzmetal angina | 33.90 | 10.51 | 17 | 64406 | 688 | 50540013 |
Exposure during pregnancy | 33.90 | 10.51 | 64 | 64359 | 120951 | 50419750 |
Stress | 33.82 | 10.51 | 147 | 64276 | 53646 | 50487055 |
Cardiac murmur | 33.69 | 10.51 | 54 | 64369 | 10730 | 50529971 |
Arteriosclerosis coronary artery | 33.69 | 10.51 | 45 | 64378 | 7591 | 50533110 |
Sinus arrest | 33.55 | 10.51 | 23 | 64400 | 1675 | 50539026 |
Fatigue | 33.20 | 10.51 | 669 | 63754 | 706932 | 49833769 |
Sinusitis | 33.10 | 10.51 | 109 | 64314 | 170449 | 50370252 |
Product solubility abnormal | 32.82 | 10.51 | 17 | 64406 | 737 | 50539964 |
Heart sounds | 32.70 | 10.51 | 16 | 64407 | 614 | 50540087 |
Bursitis infective | 32.46 | 10.51 | 20 | 64403 | 1214 | 50539487 |
Sinus node dysfunction | 32.22 | 10.51 | 32 | 64391 | 3923 | 50536778 |
Hypovolaemia | 31.80 | 10.51 | 49 | 64374 | 9416 | 50531285 |
Prolonged expiration | 30.65 | 10.51 | 16 | 64407 | 705 | 50539996 |
Dyspnoea | 29.98 | 10.51 | 910 | 63513 | 546698 | 49994003 |
Haemorrhage | 29.83 | 10.51 | 141 | 64282 | 53300 | 50487401 |
Product use in unapproved indication | 29.26 | 10.51 | 65 | 64358 | 115754 | 50424947 |
Oesophageal pain | 29.22 | 10.51 | 26 | 64397 | 2776 | 50537925 |
Hyperkeratosis | 29.15 | 10.51 | 34 | 64389 | 5001 | 50535700 |
International normalised ratio increased | 28.73 | 10.51 | 120 | 64303 | 43032 | 50497669 |
Anxiety | 28.72 | 10.51 | 349 | 64074 | 177257 | 50363444 |
Suicide attempt | 28.69 | 10.51 | 15 | 64408 | 51717 | 50488984 |
Cardiomegaly | 28.67 | 10.51 | 63 | 64360 | 15882 | 50524819 |
Injection site pruritus | 28.57 | 10.51 | 8 | 64415 | 40403 | 50500298 |
Injection site reaction | 28.50 | 10.51 | 14 | 64409 | 50018 | 50490683 |
Injection site erythema | 28.48 | 10.51 | 32 | 64391 | 74904 | 50465797 |
Malignant neoplasm progression | 28.25 | 10.51 | 27 | 64396 | 68097 | 50472604 |
Lower gastrointestinal haemorrhage | 28.02 | 10.51 | 39 | 64384 | 6840 | 50533861 |
Musculoskeletal stiffness | 27.86 | 10.51 | 78 | 64345 | 128403 | 50412298 |
Drug interaction | 26.74 | 10.51 | 379 | 64044 | 199242 | 50341459 |
Left ventricular dysfunction | 26.72 | 10.51 | 48 | 64375 | 10458 | 50530243 |
Disease progression | 26.58 | 10.51 | 51 | 64372 | 95815 | 50444886 |
Intentional product use issue | 25.93 | 10.51 | 36 | 64387 | 76882 | 50463819 |
Blood loss anaemia | 25.76 | 10.51 | 41 | 64382 | 8098 | 50532603 |
Vascular pseudoaneurysm | 25.60 | 10.51 | 18 | 64405 | 1366 | 50539335 |
Product dose omission issue | 25.39 | 10.51 | 134 | 64289 | 183704 | 50356997 |
Sputum discoloured | 25.31 | 10.51 | 54 | 64369 | 13341 | 50527360 |
Fear of eating | 25.02 | 10.51 | 11 | 64412 | 329 | 50540372 |
Melaena | 24.81 | 10.51 | 83 | 64340 | 26781 | 50513920 |
Mucosal inflammation | 24.80 | 10.51 | 10 | 64413 | 40132 | 50500569 |
Pregnancy | 24.69 | 10.51 | 4 | 64419 | 29573 | 50511128 |
Dyspnoea exertional | 24.23 | 10.51 | 129 | 64294 | 51104 | 50489597 |
Oedema peripheral | 24.07 | 10.51 | 307 | 64116 | 157654 | 50383047 |
Hyperlipidaemia | 23.77 | 10.51 | 62 | 64361 | 17428 | 50523273 |
Post procedural haemorrhage | 23.53 | 10.51 | 37 | 64386 | 7233 | 50533468 |
Neutrophil count decreased | 23.17 | 10.51 | 15 | 64408 | 46011 | 50494690 |
Psoriatic arthropathy | 22.78 | 10.51 | 16 | 64407 | 47016 | 50493685 |
Pruritus | 22.73 | 10.51 | 241 | 64182 | 283327 | 50257374 |
Coronary artery dissection | 22.28 | 10.51 | 13 | 64410 | 714 | 50539987 |
Arterial occlusive disease | 22.24 | 10.51 | 29 | 64394 | 4779 | 50535922 |
Toxicity to various agents | 22.20 | 10.51 | 387 | 64036 | 212112 | 50328589 |
Acute pulmonary oedema | 22.17 | 10.51 | 36 | 64387 | 7231 | 50533470 |
Rales | 22.14 | 10.51 | 43 | 64380 | 9935 | 50530766 |
Total lung capacity decreased | 22.06 | 10.51 | 16 | 64407 | 1275 | 50539426 |
Irritable bowel syndrome | 21.78 | 10.51 | 20 | 64403 | 51421 | 50489280 |
Presyncope | 21.67 | 10.51 | 74 | 64349 | 24124 | 50516577 |
Dermatitis bullous | 21.16 | 10.51 | 35 | 64388 | 7138 | 50533563 |
Silent myocardial infarction | 21 | 10.51 | 10 | 64413 | 361 | 50540340 |
Stomatitis | 20.89 | 10.51 | 63 | 64360 | 101281 | 50439420 |
Mitral valve incompetence | 20.81 | 10.51 | 59 | 64364 | 17412 | 50523289 |
Cerebral mass effect | 20.80 | 10.51 | 13 | 64410 | 809 | 50539892 |
Knee arthroplasty | 20.46 | 10.51 | 10 | 64413 | 35836 | 50504865 |
Hallucination | 20.40 | 10.51 | 115 | 64308 | 46542 | 50494159 |
Sinus bradycardia | 20.29 | 10.51 | 49 | 64374 | 13134 | 50527567 |
Percutaneous coronary intervention | 19.84 | 10.51 | 8 | 64415 | 192 | 50540509 |
Pituitary apoplexy | 19.81 | 10.51 | 7 | 64416 | 115 | 50540586 |
Atrioventricular block | 19.64 | 10.51 | 32 | 64391 | 6446 | 50534255 |
Diarrhoea | 19.43 | 10.51 | 586 | 63837 | 587890 | 49952811 |
Completed suicide | 19.42 | 10.51 | 94 | 64329 | 131795 | 50408906 |
Ventricular extrasystoles | 19.42 | 10.51 | 42 | 64381 | 10474 | 50530227 |
Ventricular tachycardia | 19.41 | 10.51 | 54 | 64369 | 15767 | 50524934 |
Chronic kidney disease | 19.40 | 10.51 | 101 | 64322 | 39670 | 50501031 |
Ill-defined disorder | 19.00 | 10.51 | 25 | 64398 | 54629 | 50486072 |
Autonomic dysreflexia | 18.98 | 10.51 | 9 | 64414 | 322 | 50540379 |
C-reactive protein increased | 18.74 | 10.51 | 35 | 64388 | 66439 | 50474262 |
Subdural haematoma | 18.74 | 10.51 | 47 | 64376 | 12900 | 50527801 |
Laryngospasm | 18.73 | 10.51 | 20 | 64403 | 2668 | 50538033 |
Red blood cell sedimentation rate increased | 18.72 | 10.51 | 7 | 64416 | 29409 | 50511292 |
Leukopenia | 18.65 | 10.51 | 36 | 64387 | 67492 | 50473209 |
Peripheral swelling | 18.59 | 10.51 | 170 | 64253 | 205766 | 50334935 |
Coronary artery reocclusion | 18.51 | 10.51 | 5 | 64418 | 31 | 50540670 |
Coronary artery restenosis | 18.33 | 10.51 | 9 | 64414 | 348 | 50540353 |
Colitis microscopic | 18.15 | 10.51 | 31 | 64392 | 6489 | 50534212 |
Hip arthroplasty | 18.13 | 10.51 | 8 | 64415 | 30421 | 50510280 |
Laryngotracheal oedema | 17.99 | 10.51 | 5 | 64418 | 35 | 50540666 |
Bundle branch block left | 17.85 | 10.51 | 30 | 64393 | 6200 | 50534501 |
Impaired healing | 17.75 | 10.51 | 39 | 64384 | 69747 | 50470954 |
Electrocardiogram ST segment elevation | 17.73 | 10.51 | 22 | 64401 | 3451 | 50537250 |
Blister | 17.68 | 10.51 | 53 | 64370 | 85365 | 50455336 |
Multiple organ dysfunction syndrome | 16.94 | 10.51 | 116 | 64307 | 50221 | 50490480 |
Bone marrow failure | 16.87 | 10.51 | 7 | 64416 | 27617 | 50513084 |
Lip swelling | 16.63 | 10.51 | 69 | 64354 | 24667 | 50516034 |
Bronchopulmonary aspergillosis allergic | 16.45 | 10.51 | 13 | 64410 | 1178 | 50539523 |
Swollen tongue | 16.31 | 10.51 | 76 | 64347 | 28554 | 50512147 |
Herpes zoster | 16.07 | 10.51 | 42 | 64381 | 70744 | 50469957 |
Body temperature increased | 16.07 | 10.51 | 10 | 64413 | 31331 | 50509370 |
Cardiomyopathy | 16.06 | 10.51 | 50 | 64373 | 15536 | 50525165 |
Duodenal ulcer | 16.03 | 10.51 | 30 | 64393 | 6745 | 50533956 |
Left ventricular end-diastolic pressure increased | 16.02 | 10.51 | 8 | 64415 | 321 | 50540380 |
Haematoma | 15.94 | 10.51 | 79 | 64344 | 30431 | 50510270 |
Device dislocation | 15.73 | 10.51 | 4 | 64419 | 21542 | 50519159 |
Injection site swelling | 15.69 | 10.51 | 18 | 64405 | 41755 | 50498946 |
Blood calcium increased | 15.61 | 10.51 | 32 | 64391 | 7687 | 50533014 |
Generalised tonic-clonic seizure | 15.54 | 10.51 | 7 | 64416 | 26303 | 50514398 |
Hyperhidrosis | 15.43 | 10.51 | 178 | 64245 | 89248 | 50451453 |
Erythema | 15.42 | 10.51 | 116 | 64307 | 146298 | 50394403 |
Catheterisation cardiac | 15.12 | 10.51 | 22 | 64401 | 4018 | 50536683 |
Bacteriuria | 15.06 | 10.51 | 10 | 64413 | 691 | 50540010 |
Coronary ostial stenosis | 15.02 | 10.51 | 5 | 64418 | 68 | 50540633 |
Rectal haemorrhage | 14.90 | 10.51 | 92 | 64331 | 38466 | 50502235 |
Chest discomfort | 14.88 | 10.51 | 182 | 64241 | 92540 | 50448161 |
Neuropathy peripheral | 14.80 | 10.51 | 68 | 64355 | 96689 | 50444012 |
Therapeutic product effect incomplete | 14.79 | 10.51 | 63 | 64360 | 91452 | 50449249 |
Troponin T increased | 14.50 | 10.51 | 11 | 64412 | 939 | 50539762 |
Coagulopathy | 14.46 | 10.51 | 53 | 64370 | 17891 | 50522810 |
Gastric haemorrhage | 14.45 | 10.51 | 26 | 64397 | 5670 | 50535031 |
Blood pressure decreased | 14.40 | 10.51 | 121 | 64302 | 55788 | 50484913 |
Drug eruption | 14.39 | 10.51 | 6 | 64417 | 23600 | 50517101 |
Non-cardiac chest pain | 14.34 | 10.51 | 26 | 64397 | 5706 | 50534995 |
Lung opacity | 14.32 | 10.51 | 15 | 64408 | 1958 | 50538743 |
Ventricular hypertrophy | 14.26 | 10.51 | 19 | 64404 | 3196 | 50537505 |
Cardiac failure chronic | 14.21 | 10.51 | 20 | 64403 | 3543 | 50537158 |
Peripheral ischaemia | 14.17 | 10.51 | 22 | 64401 | 4254 | 50536447 |
Therapeutic response decreased | 14.10 | 10.51 | 24 | 64399 | 47207 | 50493494 |
Sleep apnoea syndrome | 14.07 | 10.51 | 64 | 64359 | 23804 | 50516897 |
Device issue | 14.03 | 10.51 | 4 | 64419 | 19968 | 50520733 |
Headache | 13.96 | 10.51 | 516 | 63907 | 506019 | 50034682 |
Haemoptysis | 13.92 | 10.51 | 67 | 64356 | 25506 | 50515195 |
Cytomegalovirus infection | 13.78 | 10.51 | 3 | 64420 | 17959 | 50522742 |
Acne | 13.63 | 10.51 | 4 | 64419 | 19591 | 50521110 |
Flushing | 13.56 | 10.51 | 42 | 64381 | 66973 | 50473728 |
Psoriasis | 13.44 | 10.51 | 44 | 64379 | 68956 | 50471745 |
Hypokalaemia | 13.38 | 10.51 | 171 | 64252 | 87821 | 50452880 |
Coronary artery thrombosis | 13.37 | 10.51 | 11 | 64412 | 1056 | 50539645 |
Discoloured vomit | 13.30 | 10.51 | 9 | 64414 | 642 | 50540059 |
Dizziness | 13.26 | 10.51 | 553 | 63870 | 345816 | 50194885 |
Nodal rhythm | 13.22 | 10.51 | 13 | 64410 | 1574 | 50539127 |
Arteriosclerosis | 13.19 | 10.51 | 33 | 64390 | 9044 | 50531657 |
Femur fracture | 13.16 | 10.51 | 17 | 64406 | 37447 | 50503254 |
Ascites | 12.88 | 10.51 | 16 | 64407 | 35845 | 50504856 |
Ischaemia | 12.72 | 10.51 | 21 | 64402 | 4276 | 50536425 |
Nephrogenic systemic fibrosis | 12.63 | 10.51 | 21 | 64402 | 4301 | 50536400 |
Hypertensive heart disease | 12.59 | 10.51 | 15 | 64408 | 2255 | 50538446 |
Respiration abnormal | 12.58 | 10.51 | 23 | 64400 | 5079 | 50535622 |
Rheumatic fever | 12.57 | 10.51 | 3 | 64420 | 16864 | 50523837 |
Multiple injuries | 12.56 | 10.51 | 13 | 64410 | 1673 | 50539028 |
Atrioventricular block second degree | 12.52 | 10.51 | 19 | 64404 | 3602 | 50537099 |
Bronchiectasis | 12.52 | 10.51 | 35 | 64388 | 10248 | 50530453 |
Cardiogenic shock | 12.50 | 10.51 | 46 | 64377 | 15553 | 50525148 |
Cardioactive drug level increased | 12.50 | 10.51 | 14 | 64409 | 1970 | 50538731 |
Finger amputation | 12.49 | 10.51 | 8 | 64415 | 520 | 50540181 |
Palmar-plantar erythrodysaesthesia syndrome | 12.43 | 10.51 | 5 | 64418 | 20093 | 50520608 |
Obstructive airways disorder | 12.42 | 10.51 | 46 | 64377 | 15606 | 50525095 |
Periorbital haematoma | 12.40 | 10.51 | 9 | 64414 | 718 | 50539983 |
Arteriogram coronary abnormal | 12.40 | 10.51 | 3 | 64420 | 11 | 50540690 |
Hydrothorax | 12.35 | 10.51 | 9 | 64414 | 722 | 50539979 |
Colitis ischaemic | 12.26 | 10.51 | 33 | 64390 | 9450 | 50531251 |
Mitral valve calcification | 12.23 | 10.51 | 10 | 64413 | 951 | 50539750 |
Lethargy | 12.22 | 10.51 | 106 | 64317 | 49326 | 50491375 |
Essential hypertension | 12.20 | 10.51 | 21 | 64402 | 4423 | 50536278 |
No adverse event | 12.04 | 10.51 | 15 | 64408 | 33563 | 50507138 |
Urogenital disorder | 12.04 | 10.51 | 4 | 64419 | 54 | 50540647 |
Abdominal wall haematoma | 12.01 | 10.51 | 16 | 64407 | 2692 | 50538009 |
Rhabdomyolysis | 12.00 | 10.51 | 88 | 64335 | 38939 | 50501762 |
COVID-19 | 11.93 | 10.51 | 26 | 64397 | 46636 | 50494065 |
Vascular graft | 11.93 | 10.51 | 9 | 64414 | 762 | 50539939 |
Acquired epidermolysis bullosa | 11.91 | 10.51 | 4 | 64419 | 56 | 50540645 |
Inappropriate schedule of product administration | 11.89 | 10.51 | 49 | 64374 | 71782 | 50468919 |
Mental status changes | 11.86 | 10.51 | 83 | 64340 | 36189 | 50504512 |
Stent placement | 11.83 | 10.51 | 18 | 64405 | 3420 | 50537281 |
Creatinine renal clearance increased | 11.83 | 10.51 | 8 | 64415 | 570 | 50540131 |
Drug-induced liver injury | 11.80 | 10.51 | 11 | 64412 | 28084 | 50512617 |
Gastric ulcer | 11.73 | 10.51 | 56 | 64367 | 21249 | 50519452 |
Pancytopenia | 11.73 | 10.51 | 61 | 64362 | 83969 | 50456732 |
Lupus myocarditis | 11.60 | 10.51 | 4 | 64419 | 61 | 50540640 |
Foot deformity | 11.52 | 10.51 | 5 | 64418 | 19205 | 50521496 |
Arterial intramural haematoma | 11.49 | 10.51 | 3 | 64420 | 16 | 50540685 |
Platelet count decreased | 11.47 | 10.51 | 78 | 64345 | 100648 | 50440053 |
Tricuspid valve incompetence | 11.39 | 10.51 | 39 | 64384 | 12731 | 50527970 |
Throat irritation | 11.39 | 10.51 | 13 | 64410 | 30226 | 50510475 |
Depressive symptom | 11.36 | 10.51 | 17 | 64406 | 3183 | 50537518 |
Anaemia macrocytic | 11.16 | 10.51 | 15 | 64408 | 2544 | 50538157 |
Stent malfunction | 11.14 | 10.51 | 4 | 64419 | 69 | 50540632 |
Electrocardiogram T wave abnormal | 11.06 | 10.51 | 14 | 64409 | 2239 | 50538462 |
Head injury | 11.03 | 10.51 | 60 | 64363 | 23960 | 50516741 |
Ventricular fibrillation | 11.00 | 10.51 | 34 | 64389 | 10525 | 50530176 |
Left ventricular failure | 10.91 | 10.51 | 21 | 64402 | 4820 | 50535881 |
Blood urea increased | 10.89 | 10.51 | 59 | 64364 | 23526 | 50517175 |
Reflux gastritis | 10.76 | 10.51 | 9 | 64414 | 884 | 50539817 |
Tuberculosis of central nervous system | 10.71 | 10.51 | 6 | 64417 | 305 | 50540396 |
Hypertension | 10.69 | 10.51 | 348 | 64075 | 210855 | 50329846 |
Leg amputation | 10.67 | 10.51 | 13 | 64410 | 2000 | 50538701 |
Confusional state | 10.65 | 10.51 | 311 | 64112 | 185617 | 50355084 |
Acute myeloid leukaemia | 10.63 | 10.51 | 3 | 64420 | 15071 | 50525630 |
Weight increased | 10.58 | 10.51 | 187 | 64236 | 201704 | 50338997 |
Hypoosmolar state | 10.57 | 10.51 | 5 | 64418 | 178 | 50540523 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Myocardial infarction | 934.05 | 10.99 | 1147 | 60449 | 109149 | 29403782 |
Coronary artery disease | 436.21 | 10.99 | 498 | 61098 | 43692 | 29469239 |
Acute myocardial infarction | 392.90 | 10.99 | 494 | 61102 | 47944 | 29464987 |
Chest pain | 360.32 | 10.99 | 749 | 60847 | 111224 | 29401707 |
Cardiac failure congestive | 349.38 | 10.99 | 595 | 61001 | 75986 | 29436945 |
Angina pectoris | 337.79 | 10.99 | 350 | 61246 | 27500 | 29485431 |
Injury | 221.27 | 10.99 | 234 | 61362 | 18812 | 29494119 |
Fear | 217.70 | 10.99 | 171 | 61425 | 9333 | 29503598 |
Angina unstable | 214.03 | 10.99 | 179 | 61417 | 10686 | 29502245 |
Anhedonia | 190.11 | 10.99 | 141 | 61455 | 7059 | 29505872 |
Coronary arterial stent insertion | 184.93 | 10.99 | 110 | 61486 | 3787 | 29509144 |
Renal injury | 160.64 | 10.99 | 148 | 61448 | 10054 | 29502877 |
Emotional distress | 154.81 | 10.99 | 167 | 61429 | 13728 | 29499203 |
Drug abuse | 128.46 | 10.99 | 10 | 61586 | 79873 | 29433058 |
Off label use | 116.39 | 10.99 | 287 | 61309 | 300513 | 29212418 |
Product solubility abnormal | 106.60 | 10.99 | 39 | 61557 | 420 | 29512511 |
Hypotension | 103.16 | 10.99 | 725 | 60871 | 193629 | 29319302 |
Myocardial ischaemia | 97.07 | 10.99 | 142 | 61454 | 15886 | 29497045 |
Bradycardia | 96.97 | 10.99 | 329 | 61267 | 65300 | 29447631 |
Stress | 95.15 | 10.99 | 165 | 61431 | 21325 | 29491606 |
Unevaluable event | 92.52 | 10.99 | 197 | 61399 | 29654 | 29483277 |
Syncope | 89.48 | 10.99 | 371 | 61225 | 81000 | 29431931 |
Ischaemic cardiomyopathy | 85.29 | 10.99 | 80 | 61516 | 5558 | 29507373 |
Cardiac disorder | 81.84 | 10.99 | 215 | 61381 | 37048 | 29475883 |
Toxicity to various agents | 78.28 | 10.99 | 152 | 61444 | 173509 | 29339422 |
Dizziness | 78.01 | 10.99 | 667 | 60929 | 189017 | 29323914 |
Coronary artery bypass | 69.95 | 10.99 | 66 | 61530 | 4619 | 29508312 |
Anxiety | 69.93 | 10.99 | 357 | 61239 | 85008 | 29427923 |
Chronic obstructive pulmonary disease | 69.20 | 10.99 | 215 | 61381 | 40740 | 29472191 |
Pyrexia | 67.59 | 10.99 | 339 | 61257 | 287283 | 29225648 |
Neutropenia | 63.11 | 10.99 | 111 | 61485 | 131600 | 29381331 |
Coronary artery occlusion | 59.05 | 10.99 | 88 | 61508 | 10006 | 29502925 |
Product use in unapproved indication | 58.22 | 10.99 | 57 | 61539 | 86818 | 29426113 |
Cerebrovascular accident | 57.05 | 10.99 | 313 | 61283 | 76598 | 29436333 |
Acute coronary syndrome | 56.34 | 10.99 | 96 | 61500 | 12229 | 29500702 |
Febrile neutropenia | 55.21 | 10.99 | 93 | 61503 | 112147 | 29400784 |
Ventricular extrasystoles | 54.53 | 10.99 | 87 | 61509 | 10495 | 29502436 |
Atrial fibrillation | 54.07 | 10.99 | 391 | 61205 | 105255 | 29407676 |
Foetal exposure during pregnancy | 52.34 | 10.99 | 5 | 61591 | 33862 | 29479069 |
Ventricular tachycardia | 51.34 | 10.99 | 132 | 61464 | 22442 | 29490489 |
Presyncope | 49.62 | 10.99 | 106 | 61490 | 15983 | 29496948 |
Dyspnoea | 48.73 | 10.99 | 952 | 60644 | 325780 | 29187151 |
Malignant neoplasm progression | 46.61 | 10.99 | 51 | 61545 | 73808 | 29439123 |
Middle insomnia | 45.83 | 10.99 | 58 | 61538 | 5650 | 29507281 |
Renal failure | 44.99 | 10.99 | 410 | 61186 | 118189 | 29394742 |
Coronary artery stenosis | 44.89 | 10.99 | 71 | 61525 | 8502 | 29504429 |
Completed suicide | 44.16 | 10.99 | 75 | 61521 | 90171 | 29422760 |
Drug ineffective | 41.61 | 10.99 | 521 | 61075 | 362649 | 29150282 |
Ventricular fibrillation | 40.67 | 10.99 | 97 | 61499 | 15736 | 29497195 |
Troponin increased | 39.97 | 10.99 | 70 | 61526 | 9113 | 29503818 |
Pain | 39.48 | 10.99 | 537 | 61059 | 170895 | 29342036 |
Chest discomfort | 38.79 | 10.99 | 194 | 61402 | 45789 | 29467142 |
C-reactive protein increased | 38.71 | 10.99 | 22 | 61574 | 44241 | 29468690 |
Therapeutic product effect incomplete | 38.18 | 10.99 | 17 | 61579 | 39288 | 29473643 |
Cerebral artery thrombosis | 37.98 | 10.99 | 22 | 61574 | 720 | 29512211 |
Brain scan abnormal | 35.21 | 10.99 | 22 | 61574 | 828 | 29512103 |
Arteriosclerosis coronary artery | 35.19 | 10.99 | 72 | 61524 | 10533 | 29502398 |
Gastrointestinal haemorrhage | 34.87 | 10.99 | 284 | 61312 | 79249 | 29433682 |
Leukopenia | 32.79 | 10.99 | 40 | 61556 | 55163 | 29457768 |
Cardiac failure | 32.56 | 10.99 | 279 | 61317 | 79008 | 29433923 |
Drug reaction with eosinophilia and systemic symptoms | 32.50 | 10.99 | 9 | 61587 | 27983 | 29484948 |
Soft tissue mass | 30.29 | 10.99 | 18 | 61578 | 618 | 29512313 |
International normalised ratio increased | 28.57 | 10.99 | 174 | 61422 | 44198 | 29468733 |
Hepatic function abnormal | 28.37 | 10.99 | 24 | 61572 | 39235 | 29473696 |
Cytomegalovirus infection | 27.84 | 10.99 | 7 | 61589 | 23208 | 29489723 |
Prinzmetal angina | 27.68 | 10.99 | 19 | 61577 | 840 | 29512091 |
Neutrophil count decreased | 27.57 | 10.99 | 30 | 61566 | 43537 | 29469394 |
Multimorbidity | 27.20 | 10.99 | 16 | 61580 | 539 | 29512392 |
Hyperlipidaemia | 26.96 | 10.99 | 72 | 61524 | 12518 | 29500413 |
Acute kidney injury | 26.14 | 10.99 | 730 | 60866 | 264537 | 29248394 |
Mucosal inflammation | 25.81 | 10.99 | 17 | 61579 | 31578 | 29481353 |
Post procedural complication | 24.92 | 10.99 | 62 | 61534 | 10327 | 29502604 |
Renal impairment | 24.88 | 10.99 | 269 | 61327 | 81064 | 29431867 |
Cardiomegaly | 24.82 | 10.99 | 74 | 61522 | 13702 | 29499229 |
Product dose omission issue | 24.64 | 10.99 | 110 | 61486 | 96273 | 29416658 |
Electrocardiogram ST segment elevation | 24.62 | 10.99 | 38 | 61558 | 4454 | 29508477 |
Base excess decreased | 24.52 | 10.99 | 11 | 61585 | 207 | 29512724 |
Rash | 24.48 | 10.99 | 265 | 61331 | 189554 | 29323377 |
Diarrhoea | 24.47 | 10.99 | 518 | 61078 | 332180 | 29180751 |
Coronary artery thrombosis | 23.92 | 10.99 | 25 | 61571 | 1980 | 29510951 |
Orthostatic hypotension | 23.91 | 10.99 | 102 | 61494 | 22527 | 29490404 |
Treatment failure | 23.85 | 10.99 | 25 | 61571 | 36914 | 29476017 |
Neuroleptic malignant syndrome | 23.39 | 10.99 | 3 | 61593 | 16145 | 29496786 |
Oesophageal perforation | 22.69 | 10.99 | 16 | 61580 | 739 | 29512192 |
White blood cell count decreased | 22.00 | 10.99 | 94 | 61502 | 83268 | 29429663 |
Infusion related reaction | 21.89 | 10.99 | 36 | 61560 | 43850 | 29469081 |
Cardiac arrest | 21.69 | 10.99 | 273 | 61323 | 85318 | 29427613 |
Peripheral vascular disorder | 21.43 | 10.99 | 36 | 61560 | 4531 | 29508400 |
Vascular stent occlusion | 21.05 | 10.99 | 9 | 61587 | 150 | 29512781 |
Ventricular dysfunction | 20.87 | 10.99 | 30 | 61566 | 3301 | 29509630 |
Bone marrow failure | 20.81 | 10.99 | 16 | 61580 | 27433 | 29485498 |
Infection | 20.59 | 10.99 | 86 | 61510 | 76665 | 29436266 |
Post procedural haemorrhage | 20.44 | 10.99 | 47 | 61549 | 7444 | 29505487 |
Reperfusion arrhythmia | 20.35 | 10.99 | 7 | 61589 | 62 | 29512869 |
Disease progression | 20.03 | 10.99 | 95 | 61501 | 81821 | 29431110 |
Intentional product misuse | 19.66 | 10.99 | 26 | 61570 | 34635 | 29478296 |
Oxygen consumption decreased | 19.56 | 10.99 | 9 | 61587 | 180 | 29512751 |
Arteriosclerosis | 19.34 | 10.99 | 56 | 61540 | 10200 | 29502731 |
Ischaemic stroke | 19.24 | 10.99 | 75 | 61521 | 15902 | 29497029 |
Stomatitis | 18.92 | 10.99 | 30 | 61566 | 37083 | 29475848 |
Orthopnoea | 18.86 | 10.99 | 34 | 61562 | 4526 | 29508405 |
Platelet count decreased | 18.85 | 10.99 | 134 | 61462 | 104538 | 29408393 |
Alanine aminotransferase increased | 18.71 | 10.99 | 80 | 61516 | 70864 | 29442067 |
Pulmonary oedema | 18.39 | 10.99 | 152 | 61444 | 42583 | 29470348 |
Pneumocystis jirovecii pneumonia | 18.38 | 10.99 | 6 | 61590 | 16773 | 29496158 |
International normalised ratio decreased | 18.31 | 10.99 | 32 | 61564 | 4158 | 29508773 |
Rectal haemorrhage | 18.29 | 10.99 | 129 | 61467 | 34420 | 29478511 |
Blood loss anaemia | 18.10 | 10.99 | 44 | 61552 | 7222 | 29505709 |
Circulatory collapse | 18.08 | 10.99 | 82 | 61514 | 18591 | 29494340 |
Vascular graft | 17.90 | 10.99 | 18 | 61578 | 1362 | 29511569 |
Cardiac procedure complication | 17.81 | 10.99 | 8 | 61588 | 151 | 29512780 |
Laryngeal haematoma | 17.71 | 10.99 | 8 | 61588 | 153 | 29512778 |
Cytokine release syndrome | 17.70 | 10.99 | 3 | 61593 | 13116 | 29499815 |
Areflexia | 17.54 | 10.99 | 25 | 61571 | 2729 | 29510202 |
Arrhythmia | 17.21 | 10.99 | 118 | 61478 | 31195 | 29481736 |
Acute pulmonary oedema | 16.83 | 10.99 | 41 | 61555 | 6738 | 29506193 |
Carotid artery stenosis | 16.83 | 10.99 | 32 | 61564 | 4437 | 29508494 |
Cardiac arrest neonatal | 16.66 | 10.99 | 5 | 61591 | 27 | 29512904 |
Nerve degeneration | 16.49 | 10.99 | 8 | 61588 | 181 | 29512750 |
Neurotoxicity | 16.41 | 10.99 | 5 | 61591 | 14608 | 29498323 |
Labelled drug-drug interaction medication error | 16.23 | 10.99 | 59 | 61537 | 12100 | 29500831 |
Full blood count abnormal | 16.11 | 10.99 | 68 | 61528 | 14945 | 29497986 |
Sinus bradycardia | 16.09 | 10.99 | 57 | 61539 | 11546 | 29501385 |
Normochromic normocytic anaemia | 16.07 | 10.99 | 28 | 61568 | 3630 | 29509301 |
Supraventricular tachycardia | 15.86 | 10.99 | 51 | 61545 | 9833 | 29503098 |
Non-cardiac chest pain | 15.73 | 10.99 | 29 | 61567 | 3928 | 29509003 |
Coronary steal syndrome | 15.53 | 10.99 | 3 | 61593 | 0 | 29512931 |
Chronic kidney disease | 15.38 | 10.99 | 129 | 61467 | 36287 | 29476644 |
Decreased appetite | 15.27 | 10.99 | 212 | 61384 | 145130 | 29367801 |
Stent placement | 15.20 | 10.99 | 30 | 61566 | 4276 | 29508655 |
Gastrointestinal tract irritation | 14.94 | 10.99 | 8 | 61588 | 224 | 29512707 |
COVID-19 | 14.93 | 10.99 | 33 | 61563 | 35981 | 29476950 |
Vascular graft occlusion | 14.80 | 10.99 | 11 | 61585 | 552 | 29512379 |
Generalised tonic-clonic seizure | 14.71 | 10.99 | 11 | 61585 | 19128 | 29493803 |
Intentional overdose | 14.62 | 10.99 | 37 | 61559 | 38491 | 29474440 |
Ecchymosis | 14.56 | 10.99 | 37 | 61559 | 6243 | 29506688 |
Cervicogenic headache | 14.50 | 10.99 | 4 | 61592 | 15 | 29512916 |
Coagulation time prolonged | 14.28 | 10.99 | 15 | 61581 | 1195 | 29511736 |
Multiple injuries | 14.23 | 10.99 | 18 | 61578 | 1752 | 29511179 |
Atrial flutter | 14.19 | 10.99 | 62 | 61534 | 13832 | 29499099 |
Psychotic disorder | 14.03 | 10.99 | 13 | 61583 | 20341 | 29492590 |
Overdose | 13.97 | 10.99 | 103 | 61493 | 79716 | 29433215 |
Fall | 13.78 | 10.99 | 474 | 61122 | 176704 | 29336227 |
Intentional product use issue | 13.77 | 10.99 | 44 | 61552 | 42454 | 29470477 |
Discharge | 13.76 | 10.99 | 7 | 61589 | 176 | 29512755 |
Seizure | 13.64 | 10.99 | 126 | 61470 | 92997 | 29419934 |
Cold sweat | 13.63 | 10.99 | 45 | 61551 | 8797 | 29504134 |
Gastrooesophageal reflux disease | 13.53 | 10.99 | 112 | 61484 | 31384 | 29481547 |
Ureteric haemorrhage | 13.52 | 10.99 | 6 | 61590 | 110 | 29512821 |
Atrioventricular block complete | 13.46 | 10.99 | 42 | 61554 | 7969 | 29504962 |
Palmar-plantar erythrodysaesthesia syndrome | 13.39 | 10.99 | 7 | 61589 | 14752 | 29498179 |
Mitral valve incompetence | 13.33 | 10.99 | 59 | 61537 | 13234 | 29499697 |
Faeces discoloured | 13.20 | 10.99 | 59 | 61537 | 13292 | 29499639 |
Organ failure | 12.96 | 10.99 | 18 | 61578 | 1918 | 29511013 |
Melaena | 12.93 | 10.99 | 110 | 61486 | 31066 | 29481865 |
Porphyria acute | 12.88 | 10.99 | 7 | 61589 | 202 | 29512729 |
Transaminases increased | 12.85 | 10.99 | 17 | 61579 | 22645 | 29490286 |
Swollen tongue | 12.73 | 10.99 | 55 | 61541 | 12211 | 29500720 |
Intentional self-injury | 12.72 | 10.99 | 5 | 61591 | 12456 | 29500475 |
Coronary artery restenosis | 12.65 | 10.99 | 13 | 61583 | 1009 | 29511922 |
Myocardial bridging | 12.57 | 10.99 | 4 | 61592 | 27 | 29512904 |
Bronchopulmonary aspergillosis | 12.53 | 10.99 | 5 | 61591 | 12339 | 29500592 |
Superinfection | 12.50 | 10.99 | 18 | 61578 | 1983 | 29510948 |
Drug intolerance | 12.48 | 10.99 | 55 | 61541 | 48324 | 29464607 |
Hemiplegia | 12.43 | 10.99 | 36 | 61560 | 6558 | 29506373 |
Injection site pain | 12.43 | 10.99 | 31 | 61565 | 32415 | 29480516 |
Tricuspid valve incompetence | 12.30 | 10.99 | 42 | 61554 | 8352 | 29504579 |
Poor quality product administered | 12.29 | 10.99 | 16 | 61580 | 1603 | 29511328 |
Rales | 12.28 | 10.99 | 39 | 61557 | 7471 | 29505460 |
Haemoptysis | 12.26 | 10.99 | 107 | 61489 | 30443 | 29482488 |
Morning glory syndrome | 12.25 | 10.99 | 3 | 61593 | 6 | 29512925 |
Coronary ostial stenosis | 12.24 | 10.99 | 5 | 61591 | 74 | 29512857 |
Sedation | 12.14 | 10.99 | 11 | 61585 | 17394 | 29495537 |
Hiatus hernia | 11.91 | 10.99 | 36 | 61560 | 6716 | 29506215 |
Interstitial lung disease | 11.85 | 10.99 | 71 | 61525 | 57647 | 29455284 |
Neuropathy peripheral | 11.79 | 10.99 | 93 | 61503 | 70934 | 29441997 |
Arteriospasm coronary | 11.75 | 10.99 | 20 | 61576 | 2545 | 29510386 |
Death | 11.70 | 10.99 | 588 | 61008 | 341496 | 29171435 |
Reversible airways obstruction | 11.69 | 10.99 | 7 | 61589 | 244 | 29512687 |
Fungal infection | 11.68 | 10.99 | 7 | 61589 | 13678 | 29499253 |
Hyperhidrosis | 11.63 | 10.99 | 194 | 61402 | 64346 | 29448585 |
Neoplasm progression | 11.57 | 10.99 | 13 | 61583 | 18599 | 29494332 |
Pancytopenia | 11.55 | 10.99 | 114 | 61482 | 83054 | 29429877 |
General physical health deterioration | 11.53 | 10.99 | 148 | 61448 | 102709 | 29410222 |
Myocardial necrosis marker increased | 11.49 | 10.99 | 15 | 61581 | 1507 | 29511424 |
Osteonecrosis | 11.42 | 10.99 | 7 | 61589 | 13512 | 29499419 |
Ventricular asystole | 11.40 | 10.99 | 6 | 61590 | 162 | 29512769 |
Coronary bypass thrombosis | 11.39 | 10.99 | 3 | 61593 | 9 | 29512922 |
Left ventricular enlargement | 11.33 | 10.99 | 10 | 61586 | 642 | 29512289 |
Disseminated intravascular coagulation | 11.31 | 10.99 | 15 | 61581 | 19965 | 29492966 |
Product monitoring error | 11.30 | 10.99 | 20 | 61576 | 2625 | 29510306 |
Septic shock | 11.29 | 10.99 | 80 | 61516 | 62480 | 29450451 |
Herpes zoster | 11.29 | 10.99 | 29 | 61567 | 30023 | 29482908 |
Blood creatine phosphokinase MB increased | 11.27 | 10.99 | 16 | 61580 | 1741 | 29511190 |
Mean cell haemoglobin decreased | 11.20 | 10.99 | 14 | 61582 | 1347 | 29511584 |
Sepsis | 11.07 | 10.99 | 220 | 61376 | 142462 | 29370469 |
Rhabdomyolysis | 11.03 | 10.99 | 183 | 61413 | 60625 | 29452306 |
Ureteral disorder | 11.01 | 10.99 | 6 | 61590 | 174 | 29512757 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Myocardial infarction | 1761.10 | 10.28 | 1746 | 105598 | 164075 | 64227313 |
Coronary artery disease | 801.54 | 10.28 | 721 | 106623 | 59712 | 64331676 |
Acute myocardial infarction | 713.85 | 10.28 | 721 | 106623 | 68997 | 64322391 |
Cardiac failure congestive | 687.53 | 10.28 | 961 | 106383 | 129619 | 64261769 |
Angina pectoris | 566.54 | 10.28 | 522 | 106822 | 44559 | 64346829 |
Chest pain | 459.51 | 10.28 | 1130 | 106214 | 234850 | 64156538 |
Orthostatic hypotension | 457.54 | 10.28 | 472 | 106872 | 46266 | 64345122 |
Sedation complication | 420.17 | 10.28 | 244 | 107100 | 10110 | 64381278 |
Creatinine renal clearance decreased | 393.31 | 10.28 | 264 | 107080 | 14157 | 64377231 |
Angina unstable | 367.27 | 10.28 | 260 | 107084 | 15207 | 64376181 |
Coronary arterial stent insertion | 321.80 | 10.28 | 167 | 107177 | 5525 | 64385863 |
Hypotension | 312.05 | 10.28 | 1357 | 105987 | 379617 | 64011771 |
Fear | 293.82 | 10.28 | 254 | 107090 | 19917 | 64371471 |
Blood calcium decreased | 279.23 | 10.28 | 274 | 107070 | 25280 | 64366108 |
Renal injury | 276.26 | 10.28 | 219 | 107125 | 15210 | 64376178 |
Injury | 256.18 | 10.28 | 386 | 106958 | 55606 | 64335782 |
Anhedonia | 250.68 | 10.28 | 197 | 107147 | 13509 | 64377879 |
Sedation | 238.69 | 10.28 | 319 | 107025 | 41143 | 64350245 |
Cognitive disorder | 227.17 | 10.28 | 362 | 106982 | 54725 | 64336663 |
Balance disorder | 211.92 | 10.28 | 446 | 106898 | 83480 | 64307908 |
Off label use | 207.19 | 10.28 | 468 | 106876 | 632338 | 63759050 |
Emotional distress | 200.92 | 10.28 | 273 | 107071 | 35765 | 64355623 |
Renal failure | 177.39 | 10.28 | 684 | 106660 | 181004 | 64210384 |
Myocardial ischaemia | 175.62 | 10.28 | 205 | 107139 | 23046 | 64368342 |
Fall | 167.77 | 10.28 | 1227 | 106117 | 415599 | 63975789 |
Unevaluable event | 159.70 | 10.28 | 295 | 107049 | 50194 | 64341194 |
Bradycardia | 157.94 | 10.28 | 494 | 106850 | 117725 | 64273663 |
Drug abuse | 157.42 | 10.28 | 18 | 107326 | 132356 | 64259032 |
Acute coronary syndrome | 150.44 | 10.28 | 173 | 107171 | 19137 | 64372251 |
Depressed level of consciousness | 145.52 | 10.28 | 378 | 106966 | 81058 | 64310330 |
Ischaemic cardiomyopathy | 141.97 | 10.28 | 106 | 107238 | 6732 | 64384656 |
Cerebrovascular accident | 139.19 | 10.28 | 524 | 106820 | 137059 | 64254329 |
Gastrointestinal haemorrhage | 130.60 | 10.28 | 500 | 106844 | 131812 | 64259576 |
Syncope | 128.15 | 10.28 | 561 | 106783 | 157074 | 64234314 |
Coronary artery occlusion | 124.64 | 10.28 | 134 | 107210 | 13757 | 64377631 |
Drug ineffective | 121.68 | 10.28 | 860 | 106484 | 839387 | 63552001 |
Coronary artery bypass | 113.76 | 10.28 | 87 | 107257 | 5728 | 64385660 |
Pyrexia | 107.20 | 10.28 | 522 | 106822 | 558122 | 63833266 |
Chronic obstructive pulmonary disease | 106.24 | 10.28 | 309 | 107035 | 70739 | 64320649 |
Infusion related reaction | 104.43 | 10.28 | 73 | 107271 | 164394 | 64226994 |
Atrial fibrillation | 102.50 | 10.28 | 558 | 106786 | 170531 | 64220857 |
Neutropenia | 101.44 | 10.28 | 151 | 107193 | 239473 | 64151915 |
Cardiac disorder | 99.59 | 10.28 | 259 | 107085 | 55557 | 64335831 |
Stress | 98.04 | 10.28 | 271 | 107073 | 60263 | 64331125 |
Treatment failure | 97.82 | 10.28 | 36 | 107308 | 116780 | 64274608 |
Febrile neutropenia | 95.26 | 10.28 | 103 | 107241 | 187554 | 64203834 |
Mobility decreased | 95.25 | 10.28 | 337 | 107007 | 85503 | 64305885 |
Alopecia | 90.89 | 10.28 | 85 | 107259 | 165605 | 64225783 |
Hyperkalaemia | 87.59 | 10.28 | 367 | 106977 | 100762 | 64290626 |
Renal impairment | 84.68 | 10.28 | 446 | 106898 | 134571 | 64256817 |
Hand deformity | 84.32 | 10.28 | 5 | 107339 | 62766 | 64328622 |
Troponin increased | 80.32 | 10.28 | 113 | 107231 | 15286 | 64376102 |
Labile blood pressure | 79.07 | 10.28 | 47 | 107297 | 2033 | 64389355 |
Anxiety | 78.65 | 10.28 | 592 | 106752 | 202057 | 64189331 |
Coronary artery stenosis | 78.06 | 10.28 | 95 | 107249 | 11153 | 64380235 |
Cardiac failure | 77.41 | 10.28 | 429 | 106915 | 131944 | 64259444 |
Drug intolerance | 77.09 | 10.28 | 121 | 107223 | 187871 | 64203517 |
Product use in unapproved indication | 76.97 | 10.28 | 109 | 107235 | 176509 | 64214879 |
Hepatic enzyme increased | 75.67 | 10.28 | 63 | 107281 | 129880 | 64261508 |
Acute kidney injury | 74.54 | 10.28 | 1104 | 106240 | 448136 | 63943252 |
Completed suicide | 73.90 | 10.28 | 165 | 107179 | 224249 | 64167139 |
Systemic lupus erythematosus | 73.81 | 10.28 | 19 | 107325 | 77593 | 64313795 |
Rheumatoid arthritis | 72.98 | 10.28 | 100 | 107244 | 164194 | 64227194 |
Maternal exposure during pregnancy | 70.05 | 10.28 | 36 | 107308 | 95848 | 64295540 |
Infection | 69.35 | 10.28 | 126 | 107218 | 184754 | 64206634 |
Dizziness | 67.42 | 10.28 | 1047 | 106297 | 429116 | 63962272 |
Contraindicated product administered | 64.37 | 10.28 | 51 | 107293 | 107778 | 64283610 |
Synovitis | 64.18 | 10.28 | 43 | 107301 | 99047 | 64292341 |
Joint swelling | 62.55 | 10.28 | 169 | 107175 | 215213 | 64176175 |
Arteriosclerosis coronary artery | 62.54 | 10.28 | 101 | 107243 | 15428 | 64375960 |
Malignant neoplasm progression | 60.60 | 10.28 | 59 | 107285 | 112812 | 64278576 |
Injection site pain | 60.09 | 10.28 | 58 | 107286 | 111350 | 64280038 |
Dyspnoea | 60.04 | 10.28 | 1592 | 105752 | 717082 | 63674306 |
Peripheral vascular disorder | 58.15 | 10.28 | 66 | 107278 | 7195 | 64384193 |
Constipation | 57.94 | 10.28 | 610 | 106734 | 228727 | 64162661 |
Glossodynia | 57.51 | 10.28 | 18 | 107326 | 64678 | 64326710 |
Product solubility abnormal | 57.35 | 10.28 | 28 | 107316 | 811 | 64390577 |
Presyncope | 56.71 | 10.28 | 157 | 107187 | 34932 | 64356456 |
Therapeutic product effect decreased | 55.58 | 10.28 | 66 | 107278 | 115285 | 64276103 |
Arthralgia | 55.55 | 10.28 | 470 | 106874 | 441790 | 63949598 |
Arthropathy | 55.37 | 10.28 | 72 | 107272 | 120895 | 64270493 |
Abdominal discomfort | 55.27 | 10.28 | 140 | 107204 | 182182 | 64209206 |
Ventricular tachycardia | 55.07 | 10.28 | 153 | 107191 | 34112 | 64357276 |
Nasopharyngitis | 51.71 | 10.28 | 161 | 107183 | 195912 | 64195476 |
Ventricular fibrillation | 50.25 | 10.28 | 118 | 107226 | 23742 | 64367646 |
Cardiomegaly | 49.74 | 10.28 | 117 | 107227 | 23567 | 64367821 |
Rash | 49.54 | 10.28 | 506 | 106838 | 458043 | 63933345 |
White blood cell count decreased | 48.76 | 10.28 | 120 | 107224 | 157717 | 64233671 |
Product use issue | 48.73 | 10.28 | 113 | 107231 | 151602 | 64239786 |
Diarrhoea | 48.61 | 10.28 | 879 | 106465 | 721825 | 63669563 |
Transient ischaemic attack | 48.59 | 10.28 | 173 | 107171 | 44009 | 64347379 |
International normalised ratio increased | 47.88 | 10.28 | 259 | 107085 | 78908 | 64312480 |
Pulmonary oedema | 46.65 | 10.28 | 256 | 107088 | 78418 | 64312970 |
Cardiac arrest | 46.30 | 10.28 | 425 | 106919 | 153639 | 64237749 |
Discomfort | 46.11 | 10.28 | 40 | 107304 | 80838 | 64310550 |
C-reactive protein increased | 46.05 | 10.28 | 54 | 107290 | 94855 | 64296533 |
Product dose omission issue | 45.83 | 10.28 | 168 | 107176 | 194579 | 64196809 |
Prinzmetal angina | 44.57 | 10.28 | 29 | 107315 | 1474 | 64389914 |
Arteriospasm coronary | 44.32 | 10.28 | 50 | 107294 | 5415 | 64385973 |
Neutrophil count decreased | 44.22 | 10.28 | 38 | 107306 | 77158 | 64314230 |
Helicobacter infection | 43.67 | 10.28 | 6 | 107338 | 38356 | 64353032 |
Mucosal inflammation | 43.51 | 10.28 | 25 | 107319 | 62559 | 64328829 |
Pericarditis | 43.43 | 10.28 | 25 | 107319 | 62491 | 64328897 |
Injection site erythema | 42.86 | 10.28 | 33 | 107311 | 70767 | 64320621 |
Post procedural haemorrhage | 42.30 | 10.28 | 75 | 107269 | 12356 | 64379032 |
Sinusitis | 41.97 | 10.28 | 115 | 107229 | 145813 | 64245575 |
Leukopenia | 41.63 | 10.28 | 65 | 107279 | 101177 | 64290211 |
Hepatic ischaemia | 41.23 | 10.28 | 24 | 107320 | 998 | 64390390 |
Condition aggravated | 41.00 | 10.28 | 409 | 106935 | 372017 | 64019371 |
Intentional overdose | 40.68 | 10.28 | 54 | 107290 | 89890 | 64301498 |
Hyperlipidaemia | 40.34 | 10.28 | 106 | 107238 | 22870 | 64368518 |
Therapeutic product effect incomplete | 40.16 | 10.28 | 69 | 107275 | 103413 | 64287975 |
Swelling | 39.16 | 10.28 | 136 | 107208 | 160082 | 64231306 |
Hypersensitivity | 39.02 | 10.28 | 181 | 107163 | 196271 | 64195117 |
Exposure during pregnancy | 38.98 | 10.28 | 43 | 107301 | 77632 | 64313756 |
Haemorrhage | 38.53 | 10.28 | 245 | 107099 | 79106 | 64312282 |
Brain scan abnormal | 38.27 | 10.28 | 24 | 107320 | 1144 | 64390244 |
Bone marrow failure | 38.11 | 10.28 | 16 | 107328 | 47936 | 64343452 |
Duodenal ulcer perforation | 38.07 | 10.28 | 6 | 107338 | 34619 | 64356769 |
Melaena | 37.83 | 10.28 | 183 | 107161 | 53365 | 64338023 |
Blood loss anaemia | 37.58 | 10.28 | 76 | 107268 | 13816 | 64377572 |
Cytomegalovirus infection | 37.55 | 10.28 | 8 | 107336 | 37191 | 64354197 |
Intentional product use issue | 37.55 | 10.28 | 63 | 107281 | 95301 | 64296087 |
Coronary artery thrombosis | 37.52 | 10.28 | 34 | 107310 | 2835 | 64388553 |
Hypoglycaemia | 37.33 | 10.28 | 267 | 107077 | 89625 | 64301763 |
Ventricular extrasystoles | 36.16 | 10.28 | 86 | 107258 | 17443 | 64373945 |
Rectal haemorrhage | 35.87 | 10.28 | 200 | 107144 | 61617 | 64329771 |
Disease progression | 35.48 | 10.28 | 119 | 107225 | 141561 | 64249827 |
Sinus node dysfunction | 35.45 | 10.28 | 50 | 107294 | 6778 | 64384610 |
Injection site reaction | 34.85 | 10.28 | 17 | 107327 | 46647 | 64344741 |
Injection site pruritus | 34.57 | 10.28 | 10 | 107334 | 37816 | 64353572 |
Stomatitis | 34.10 | 10.28 | 83 | 107261 | 109522 | 64281866 |
Middle insomnia | 33.12 | 10.28 | 69 | 107275 | 12808 | 64378580 |
Muscle relaxant therapy | 32.85 | 10.28 | 12 | 107332 | 164 | 64391224 |
Cerebral artery thrombosis | 32.80 | 10.28 | 21 | 107323 | 1038 | 64390350 |
Angioplasty | 32.50 | 10.28 | 25 | 107319 | 1660 | 64389728 |
Acute pulmonary oedema | 32.21 | 10.28 | 68 | 107276 | 12741 | 64378647 |
Cardiac murmur | 32.16 | 10.28 | 64 | 107280 | 11499 | 64379889 |
Erythema | 31.71 | 10.28 | 182 | 107162 | 186888 | 64204500 |
Chest discomfort | 31.26 | 10.28 | 313 | 107031 | 115793 | 64275595 |
Haemoptysis | 30.70 | 10.28 | 162 | 107182 | 48886 | 64342502 |
Mitral valve incompetence | 30.69 | 10.28 | 103 | 107241 | 25435 | 64365953 |
Drug reaction with eosinophilia and systemic symptoms | 30.67 | 10.28 | 27 | 107317 | 54190 | 64337198 |
Sinus bradycardia | 29.91 | 10.28 | 95 | 107249 | 22798 | 64368590 |
Intentional self-injury | 29.83 | 10.28 | 6 | 107338 | 29038 | 64362350 |
Drug interaction | 29.75 | 10.28 | 801 | 106543 | 361282 | 64030106 |
Arteriosclerosis | 29.68 | 10.28 | 75 | 107269 | 15802 | 64375586 |
Neurotoxicity | 29.56 | 10.28 | 5 | 107339 | 27399 | 64363989 |
Neuropathy peripheral | 29.23 | 10.28 | 99 | 107245 | 117426 | 64273962 |
Coronary artery restenosis | 28.86 | 10.28 | 21 | 107323 | 1281 | 64390107 |
Fear of eating | 28.82 | 10.28 | 14 | 107330 | 401 | 64390987 |
Rales | 28.53 | 10.28 | 72 | 107272 | 15157 | 64376231 |
Vascular graft | 28.26 | 10.28 | 24 | 107320 | 1835 | 64389553 |
Soft tissue mass | 28.09 | 10.28 | 18 | 107326 | 891 | 64390497 |
Herpes zoster | 27.89 | 10.28 | 56 | 107288 | 79131 | 64312257 |
Generalised tonic-clonic seizure | 27.59 | 10.28 | 16 | 107328 | 39841 | 64351547 |
Vascular stent occlusion | 27.50 | 10.28 | 11 | 107333 | 195 | 64391193 |
Prolonged expiration | 27.19 | 10.28 | 17 | 107327 | 806 | 64390582 |
Pain | 27.01 | 10.28 | 1152 | 106192 | 552359 | 63839029 |
Chronic kidney disease | 26.99 | 10.28 | 177 | 107167 | 57742 | 64333646 |
Hyponatraemia | 26.65 | 10.28 | 370 | 106974 | 147969 | 64243419 |
Heart sounds | 26.57 | 10.28 | 15 | 107329 | 588 | 64390800 |
Non-cardiac chest pain | 26.53 | 10.28 | 50 | 107294 | 8630 | 64382758 |
Multiple injuries | 26.44 | 10.28 | 30 | 107314 | 3269 | 64388119 |
Psoriatic arthropathy | 26.42 | 10.28 | 20 | 107324 | 43261 | 64348127 |
Platelet count decreased | 26.40 | 10.28 | 167 | 107177 | 167544 | 64223844 |
Pruritus | 26.26 | 10.28 | 364 | 106980 | 312036 | 64079352 |
Carotid artery stenosis | 25.85 | 10.28 | 47 | 107297 | 7894 | 64383494 |
Oesophageal pain | 25.02 | 10.28 | 29 | 107315 | 3234 | 64388154 |
Impaired healing | 24.69 | 10.28 | 39 | 107305 | 60434 | 64330954 |
Post procedural complication | 24.67 | 10.28 | 85 | 107259 | 21268 | 64370120 |
Rhabdomyolysis | 24.55 | 10.28 | 247 | 107097 | 91479 | 64299909 |
Lymphadenopathy | 24.36 | 10.28 | 25 | 107319 | 46661 | 64344727 |
Muscle injury | 24.14 | 10.28 | 7 | 107337 | 26430 | 64364958 |
Multimorbidity | 23.99 | 10.28 | 17 | 107327 | 995 | 64390393 |
Pancytopenia | 23.97 | 10.28 | 140 | 107204 | 143169 | 64248219 |
COVID-19 | 23.86 | 10.28 | 45 | 107299 | 65095 | 64326293 |
Fatigue | 23.77 | 10.28 | 1012 | 106332 | 747718 | 63643670 |
Electrocardiogram ST segment elevation | 23.68 | 10.28 | 43 | 107301 | 7216 | 64384172 |
Ischaemia | 23.60 | 10.28 | 43 | 107301 | 7235 | 64384153 |
Arrhythmia | 23.59 | 10.28 | 160 | 107184 | 52784 | 64338604 |
Coronary ostial stenosis | 23.52 | 10.28 | 9 | 107335 | 141 | 64391247 |
Coagulation time prolonged | 23.41 | 10.28 | 23 | 107321 | 2123 | 64389265 |
Haematemesis | 23.36 | 10.28 | 146 | 107198 | 46853 | 64344535 |
Suicide attempt | 22.70 | 10.28 | 53 | 107291 | 70954 | 64320434 |
Vascular pseudoaneurysm | 22.68 | 10.28 | 27 | 107317 | 3097 | 64388291 |
Cardiac procedure complication | 22.68 | 10.28 | 11 | 107333 | 314 | 64391074 |
Neoplasm progression | 22.46 | 10.28 | 21 | 107323 | 40943 | 64350445 |
Pneumocystis jirovecii pneumonia | 22.32 | 10.28 | 9 | 107335 | 27625 | 64363763 |
Swollen tongue | 22.25 | 10.28 | 116 | 107228 | 34838 | 64356550 |
Neuroleptic malignant syndrome | 22.13 | 10.28 | 7 | 107337 | 24989 | 64366399 |
Dyspnoea exertional | 21.93 | 10.28 | 203 | 107141 | 73527 | 64317861 |
Percutaneous coronary intervention | 21.88 | 10.28 | 11 | 107333 | 340 | 64391048 |
Injection site swelling | 21.74 | 10.28 | 22 | 107322 | 41331 | 64350057 |
Tricuspid valve incompetence | 21.71 | 10.28 | 70 | 107274 | 16933 | 64374455 |
Bronchopulmonary aspergillosis | 21.69 | 10.28 | 3 | 107341 | 19082 | 64372306 |
Coronary steal syndrome | 21.60 | 10.28 | 4 | 107340 | 0 | 64391388 |
Bundle branch block left | 21.54 | 10.28 | 50 | 107294 | 9984 | 64381404 |
Circulatory collapse | 21.51 | 10.28 | 112 | 107232 | 33620 | 64357768 |
Labelled drug-drug interaction medication error | 21.42 | 10.28 | 83 | 107261 | 21979 | 64369409 |
Hepatic function abnormal | 21.37 | 10.28 | 47 | 107297 | 64266 | 64327122 |
Base excess decreased | 21.36 | 10.28 | 11 | 107333 | 358 | 64391030 |
Haematoma | 21.34 | 10.28 | 141 | 107203 | 46109 | 64345279 |
Oesophageal perforation | 21.30 | 10.28 | 16 | 107328 | 1025 | 64390363 |
Acne | 21.28 | 10.28 | 6 | 107338 | 23075 | 64368313 |
Sinus arrest | 21.28 | 10.28 | 26 | 107318 | 3064 | 64388324 |
Flushing | 21.12 | 10.28 | 64 | 107280 | 78584 | 64312804 |
Ischaemic stroke | 21.06 | 10.28 | 100 | 107244 | 28935 | 64362453 |
Coronary artery dissection | 20.91 | 10.28 | 15 | 107329 | 895 | 64390493 |
Haematuria | 20.85 | 10.28 | 172 | 107172 | 60299 | 64331089 |
Palmar-plantar erythrodysaesthesia syndrome | 20.77 | 10.28 | 11 | 107333 | 28808 | 64362580 |
Obstructive airways disorder | 20.73 | 10.28 | 85 | 107259 | 23100 | 64368288 |
Progressive multifocal leukoencephalopathy | 20.41 | 10.28 | 3 | 107341 | 18229 | 64373159 |
Inappropriate schedule of product administration | 20.15 | 10.28 | 82 | 107262 | 92204 | 64299184 |
Confusional state | 20.10 | 10.28 | 573 | 106771 | 260571 | 64130817 |
Supraventricular tachycardia | 19.91 | 10.28 | 73 | 107271 | 18834 | 64372554 |
Essential hypertension | 19.85 | 10.28 | 33 | 107311 | 5161 | 64386227 |
Coronary artery reocclusion | 19.68 | 10.28 | 8 | 107336 | 148 | 64391240 |
Faeces discoloured | 19.68 | 10.28 | 90 | 107254 | 25639 | 64365749 |
Weight increased | 19.59 | 10.28 | 244 | 107100 | 213104 | 64178284 |
Atrioventricular block second degree | 19.51 | 10.28 | 37 | 107307 | 6417 | 64384971 |
Hyperhidrosis | 19.45 | 10.28 | 304 | 107040 | 124616 | 64266772 |
Areflexia | 19.39 | 10.28 | 32 | 107312 | 4975 | 64386413 |
Lower gastrointestinal haemorrhage | 19.28 | 10.28 | 59 | 107285 | 13880 | 64377508 |
Laryngeal haematoma | 19.25 | 10.28 | 8 | 107336 | 157 | 64391231 |
Drug resistance | 19.24 | 10.28 | 18 | 107326 | 35084 | 64356304 |
Atrioventricular block complete | 18.99 | 10.28 | 60 | 107284 | 14358 | 64377030 |
Cardiomyopathy | 18.88 | 10.28 | 88 | 107256 | 25268 | 64366120 |
Hip arthroplasty | 18.87 | 10.28 | 6 | 107338 | 21345 | 64370043 |
Septic shock | 18.71 | 10.28 | 101 | 107243 | 105336 | 64286052 |
Cold sweat | 18.58 | 10.28 | 65 | 107279 | 16390 | 64374998 |
Irritable bowel syndrome | 18.40 | 10.28 | 21 | 107323 | 37348 | 64354040 |
Sleep apnoea syndrome | 18.30 | 10.28 | 98 | 107246 | 29734 | 64361654 |
Multiple sclerosis relapse | 18.29 | 10.28 | 25 | 107319 | 41110 | 64350278 |
Musculoskeletal stiffness | 18.21 | 10.28 | 125 | 107219 | 123081 | 64268307 |
Ventricular dysfunction | 18.19 | 10.28 | 32 | 107312 | 5238 | 64386150 |
Stent placement | 18.17 | 10.28 | 33 | 107311 | 5538 | 64385850 |
Cytokine release syndrome | 18.15 | 10.28 | 6 | 107338 | 20823 | 64370565 |
Vascular stent thrombosis | 18.01 | 10.28 | 25 | 107319 | 3339 | 64388049 |
Oxygen consumption decreased | 18.00 | 10.28 | 10 | 107334 | 380 | 64391008 |
International normalised ratio decreased | 18.00 | 10.28 | 39 | 107305 | 7439 | 64383949 |
Blood creatine phosphokinase MB increased | 17.96 | 10.28 | 22 | 107322 | 2599 | 64388789 |
Peripheral swelling | 17.81 | 10.28 | 243 | 107101 | 208910 | 64182478 |
Atrioventricular block | 17.70 | 10.28 | 52 | 107292 | 11963 | 64379425 |
Acute myeloid leukaemia | 17.66 | 10.28 | 12 | 107332 | 27451 | 64363937 |
Head injury | 17.57 | 10.28 | 104 | 107240 | 32738 | 64358650 |
Silent myocardial infarction | 17.53 | 10.28 | 12 | 107332 | 664 | 64390724 |
Autonomic dysreflexia | 17.46 | 10.28 | 10 | 107334 | 403 | 64390985 |
Therapeutic response decreased | 17.45 | 10.28 | 38 | 107306 | 52150 | 64339238 |
Normochromic normocytic anaemia | 17.38 | 10.28 | 36 | 107308 | 6654 | 64384734 |
Drug-induced liver injury | 17.37 | 10.28 | 33 | 107311 | 47610 | 64343778 |
Hepatorenal syndrome | 17.37 | 10.28 | 26 | 107318 | 3720 | 64387668 |
Arterial stenosis | 17.31 | 10.28 | 16 | 107328 | 1369 | 64390019 |
Red blood cell sedimentation rate increased | 17.14 | 10.28 | 16 | 107328 | 31219 | 64360169 |
Knee arthroplasty | 17.10 | 10.28 | 12 | 107332 | 26987 | 64364401 |
Hepatotoxicity | 17.06 | 10.28 | 25 | 107319 | 39937 | 64351451 |
Left ventricular failure | 17.04 | 10.28 | 41 | 107303 | 8376 | 64383012 |
Inflammation | 16.92 | 10.28 | 54 | 107290 | 65246 | 64326142 |
Hot flush | 16.88 | 10.28 | 32 | 107312 | 46203 | 64345185 |
Ventricular hypertrophy | 16.86 | 10.28 | 35 | 107309 | 6481 | 64384907 |
Heparin-induced thrombocytopenia | 16.85 | 10.28 | 41 | 107303 | 8438 | 64382950 |
Wheezing | 16.56 | 10.28 | 206 | 107138 | 80373 | 64311015 |
Subdural haematoma | 16.43 | 10.28 | 91 | 107253 | 27963 | 64363425 |
Psychotic disorder | 16.42 | 10.28 | 20 | 107324 | 34558 | 64356830 |
Headache | 16.26 | 10.28 | 718 | 106626 | 528749 | 63862639 |
Arterial occlusive disease | 16.15 | 10.28 | 36 | 107308 | 6997 | 64384391 |
Product complaint | 15.98 | 10.28 | 50 | 107294 | 11904 | 64379484 |
Weight decreased | 15.96 | 10.28 | 358 | 106986 | 285381 | 64106007 |
Breast cancer | 15.91 | 10.28 | 15 | 107329 | 29133 | 64362255 |
Orthopnoea | 15.89 | 10.28 | 42 | 107302 | 9092 | 64382296 |
Left ventricular dysfunction | 15.83 | 10.28 | 63 | 107281 | 16891 | 64374497 |
Nausea | 15.79 | 10.28 | 1111 | 106233 | 784689 | 63606699 |
Oedema peripheral | 15.76 | 10.28 | 460 | 106884 | 209857 | 64181531 |
Ventricular asystole | 15.74 | 10.28 | 8 | 107336 | 253 | 64391135 |
Body temperature increased | 15.59 | 10.28 | 23 | 107321 | 36643 | 64354745 |
Gastrooesophageal reflux disease | 15.58 | 10.28 | 209 | 107135 | 82934 | 64308454 |
Laryngotracheal oedema | 15.56 | 10.28 | 5 | 107339 | 45 | 64391343 |
Pituitary apoplexy | 15.47 | 10.28 | 7 | 107337 | 170 | 64391218 |
Haemophagocytic lymphohistiocytosis | 15.47 | 10.28 | 5 | 107339 | 17604 | 64373784 |
Nerve degeneration | 15.46 | 10.28 | 8 | 107336 | 263 | 64391125 |
Vascular graft occlusion | 15.34 | 10.28 | 11 | 107333 | 656 | 64390732 |
Device related infection | 15.31 | 10.28 | 17 | 107327 | 30609 | 64360779 |
Seizure | 15.27 | 10.28 | 191 | 107153 | 166701 | 64224687 |
Oral herpes | 15.18 | 10.28 | 9 | 107335 | 22143 | 64369245 |
Mouth ulceration | 15.16 | 10.28 | 19 | 107325 | 32425 | 64358963 |
Full blood count abnormal | 15.14 | 10.28 | 93 | 107251 | 29664 | 64361724 |
Alanine aminotransferase increased | 15.13 | 10.28 | 153 | 107191 | 138878 | 64252510 |
Hyperkeratosis | 15.12 | 10.28 | 34 | 107310 | 6647 | 64384741 |
Urea renal clearance decreased | 15.00 | 10.28 | 4 | 107340 | 17 | 64391371 |
Myocardial bridging | 15.00 | 10.28 | 4 | 107340 | 17 | 64391371 |
Atrial flutter | 14.98 | 10.28 | 68 | 107276 | 19312 | 64372076 |
Psoriasis | 14.86 | 10.28 | 65 | 107279 | 71638 | 64319750 |
Wound | 14.85 | 10.28 | 71 | 107273 | 76406 | 64314982 |
Hypovolaemia | 14.82 | 10.28 | 58 | 107286 | 15428 | 64375960 |
Abdominal rigidity | 14.78 | 10.28 | 20 | 107324 | 2607 | 64388781 |
Blood pressure decreased | 14.67 | 10.28 | 213 | 107131 | 85986 | 64305402 |
Hallucination | 14.49 | 10.28 | 185 | 107159 | 72603 | 64318785 |
Overdose | 14.45 | 10.28 | 183 | 107161 | 159383 | 64232005 |
Multiple organ dysfunction syndrome | 14.37 | 10.28 | 243 | 107101 | 101170 | 64290218 |
Anaemia | 14.36 | 10.28 | 769 | 106575 | 377911 | 64013477 |
Normochromic anaemia | 14.27 | 10.28 | 9 | 107335 | 433 | 64390955 |
Oropharyngeal pain | 14.23 | 10.28 | 88 | 107256 | 88779 | 64302609 |
Coronary no-reflow phenomenon | 14.15 | 10.28 | 4 | 107340 | 22 | 64391366 |
Drug eruption | 14.10 | 10.28 | 24 | 107320 | 36112 | 64355276 |
Peripheral ischaemia | 14.04 | 10.28 | 38 | 107306 | 8340 | 64383048 |
Bacteriuria | 13.99 | 10.28 | 12 | 107332 | 930 | 64390458 |
Ecchymosis | 13.82 | 10.28 | 53 | 107291 | 13969 | 64377419 |
Thrombocytopenia | 13.78 | 10.28 | 276 | 107068 | 223525 | 64167863 |
Cervicogenic headache | 13.72 | 10.28 | 4 | 107340 | 25 | 64391363 |
Transaminases increased | 13.68 | 10.28 | 34 | 107310 | 44560 | 64346828 |
Intentional product misuse | 13.53 | 10.28 | 68 | 107276 | 72227 | 64319161 |
Finger amputation | 13.49 | 10.28 | 10 | 107334 | 628 | 64390760 |
Blood creatine phosphokinase increased | 13.48 | 10.28 | 153 | 107191 | 58405 | 64332983 |
Lip swelling | 13.37 | 10.28 | 95 | 107249 | 31812 | 64359576 |
Hypertension | 13.37 | 10.28 | 543 | 106801 | 258718 | 64132670 |
Extrapyramidal disorder | 13.32 | 10.28 | 8 | 107336 | 19544 | 64371844 |
Myelosuppression | 13.32 | 10.28 | 12 | 107332 | 23818 | 64367570 |
Osteonecrosis of jaw | 13.32 | 10.28 | 29 | 107315 | 39796 | 64351592 |
Dilatation atrial | 13.30 | 10.28 | 22 | 107322 | 3428 | 64387960 |
Ill-defined disorder | 13.20 | 10.28 | 34 | 107310 | 44018 | 64347370 |
Upper gastrointestinal haemorrhage | 13.13 | 10.28 | 102 | 107242 | 35118 | 64356270 |
No adverse event | 13.06 | 10.28 | 17 | 107327 | 28544 | 64362844 |
Osteoporosis | 12.98 | 10.28 | 32 | 107312 | 42048 | 64349340 |
Morning glory syndrome | 12.91 | 10.28 | 3 | 107341 | 6 | 64391382 |
Left ventricular enlargement | 12.87 | 10.28 | 10 | 107334 | 674 | 64390714 |
Cerebral mass effect | 12.81 | 10.28 | 15 | 107329 | 1691 | 64389697 |
Atrioventricular block first degree | 12.64 | 10.28 | 43 | 107301 | 10691 | 64380697 |
Sputum discoloured | 12.59 | 10.28 | 61 | 107283 | 17795 | 64373593 |
Injection site bruising | 12.57 | 10.28 | 26 | 107318 | 36347 | 64355041 |
Gastrointestinal tract irritation | 12.55 | 10.28 | 9 | 107335 | 537 | 64390851 |
Hiatus hernia | 12.54 | 10.28 | 66 | 107278 | 19891 | 64371497 |
Blister | 12.54 | 10.28 | 81 | 107263 | 80886 | 64310502 |
Product impurity | 12.53 | 10.28 | 5 | 107339 | 88 | 64391300 |
Arthritis | 12.40 | 10.28 | 85 | 107259 | 83729 | 64307659 |
General physical health deterioration | 12.32 | 10.28 | 253 | 107091 | 204172 | 64187216 |
Left ventricular end-diastolic pressure increased | 12.28 | 10.28 | 9 | 107335 | 555 | 64390833 |
Fear of death | 12.25 | 10.28 | 13 | 107331 | 1314 | 64390074 |
Sepsis | 12.18 | 10.28 | 291 | 107053 | 230050 | 64161338 |
Brain natriuretic peptide increased | 12.18 | 10.28 | 34 | 107310 | 7599 | 64383789 |
Reperfusion arrhythmia | 12.16 | 10.28 | 7 | 107337 | 285 | 64391103 |
Candida infection | 12.14 | 10.28 | 21 | 107323 | 31398 | 64359990 |
Metastases to central nervous system | 12.13 | 10.28 | 4 | 107340 | 13908 | 64377480 |
Coronary bypass thrombosis | 12.06 | 10.28 | 3 | 107341 | 9 | 64391379 |
Immune reconstitution inflammatory syndrome | 11.95 | 10.28 | 3 | 107341 | 12467 | 64378921 |
Poor venous access | 11.88 | 10.28 | 3 | 107341 | 12414 | 64378974 |
Accidental exposure to product | 11.74 | 10.28 | 16 | 107328 | 26348 | 64365040 |
Appendicitis | 11.66 | 10.28 | 4 | 107340 | 13565 | 64377823 |
Viral infection | 11.53 | 10.28 | 27 | 107317 | 36113 | 64355275 |
Superinfection | 11.40 | 10.28 | 22 | 107322 | 3864 | 64387524 |
Therapy interrupted | 11.31 | 10.28 | 10 | 107334 | 20026 | 64371362 |
Organ failure | 11.19 | 10.28 | 21 | 107323 | 3612 | 64387776 |
Application site rash | 11.18 | 10.28 | 15 | 107329 | 1939 | 64389449 |
Infarction | 11.11 | 10.28 | 22 | 107322 | 3938 | 64387450 |
Myocardial necrosis marker increased | 11.11 | 10.28 | 18 | 107326 | 2757 | 64388631 |
Total lung capacity decreased | 11.07 | 10.28 | 14 | 107330 | 1708 | 64389680 |
Diabetic neuropathy | 11.04 | 10.28 | 27 | 107317 | 5574 | 64385814 |
Coagulation time abnormal | 10.97 | 10.28 | 6 | 107338 | 221 | 64391167 |
Productive cough | 10.96 | 10.28 | 177 | 107167 | 73026 | 64318362 |
Urticaria | 10.86 | 10.28 | 176 | 107168 | 147141 | 64244247 |
Blood chloride decreased | 10.83 | 10.28 | 32 | 107312 | 7384 | 64384004 |
Colitis microscopic | 10.79 | 10.28 | 32 | 107312 | 7400 | 64383988 |
Throat irritation | 10.79 | 10.28 | 24 | 107320 | 32687 | 64358701 |
Blood calcium increased | 10.75 | 10.28 | 35 | 107309 | 8507 | 64382881 |
Laryngospasm | 10.72 | 10.28 | 20 | 107324 | 3425 | 64387963 |
Coronary angioplasty | 10.68 | 10.28 | 7 | 107337 | 360 | 64391028 |
Therapy non-responder | 10.68 | 10.28 | 65 | 107279 | 65834 | 64325554 |
Respiratory depression | 10.67 | 10.28 | 14 | 107330 | 23429 | 64367959 |
Depression | 10.65 | 10.28 | 389 | 106955 | 182902 | 64208486 |
Cardioactive drug level increased | 10.64 | 10.28 | 20 | 107324 | 3445 | 64387943 |
Mania | 10.63 | 10.28 | 7 | 107337 | 16279 | 64375109 |
Oesophageal carcinoma | 10.58 | 10.28 | 24 | 107320 | 4719 | 64386669 |
Serotonin syndrome | 10.52 | 10.28 | 32 | 107312 | 39250 | 64352138 |
Aplastic anaemia | 10.50 | 10.28 | 5 | 107339 | 13915 | 64377473 |
Femur fracture | 10.49 | 10.28 | 26 | 107318 | 34109 | 64357279 |
Interstitial lung disease | 10.44 | 10.28 | 108 | 107236 | 97624 | 64293764 |
Product monitoring error | 10.44 | 10.28 | 26 | 107318 | 5428 | 64385960 |
Troponin T increased | 10.44 | 10.28 | 16 | 107328 | 2337 | 64389051 |
QRS axis abnormal | 10.42 | 10.28 | 14 | 107330 | 1813 | 64389575 |
Intraventricular haemorrhage | 10.39 | 10.28 | 22 | 107322 | 4131 | 64387257 |
Hyperbilirubinaemia | 10.35 | 10.28 | 12 | 107332 | 21193 | 64370195 |
None
Source | Code | Description |
---|---|---|
ATC | C01DA02 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY VASODILATORS USED IN CARDIAC DISEASES Organic nitrates |
ATC | C01DA52 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY VASODILATORS USED IN CARDIAC DISEASES Organic nitrates |
ATC | C05AE01 | CARDIOVASCULAR SYSTEM VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Muscle relaxants |
FDA CS | M0014874 | Nitrates |
FDA PE | N0000009909 | Vasodilation |
FDA EPC | N0000175415 | Nitrate Vasodilator |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D053834 | Explosive Agents |
MeSH PA | D014665 | Vasodilator Agents |
CHEBI has role | CHEBI:35620 | vasodilator agents |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:50266 | Prodrugs |
CHEBI has role | CHEBI:50566 | nitric oxide generators |
CHEBI has role | CHEBI:51371 | muscle relaxants |
CHEBI has role | CHEBI:63490 | explosive compounds |
CHEBI has role | CHEBI:66993 | tocolytic drugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Angina pectoris | indication | 194828000 | |
Left ventricular cardiac dysfunction | indication | 429589006 | |
Perioperative hypertension | indication | 434711000124103 | |
Angina Pectoris Prevention | indication | ||
Myocardial infarction | off-label use | 22298006 | DOID:5844 |
Anal fissure | off-label use | 30037006 | |
Decompensated cardiac failure | off-label use | 195111005 | |
Extravasation injury | off-label use | 371100002 | |
Acute coronary syndrome | off-label use | 394659003 | |
Hypertensive urgency | off-label use | 443482000 | |
Hypovolemia | contraindication | 28560003 | |
Cardiac tamponade | contraindication | 35304003 | DOID:115 |
Methemoglobinemia | contraindication | 38959009 | DOID:10783 |
Low blood pressure | contraindication | 45007003 | |
Chronic heart failure | contraindication | 48447003 | |
Injury of head | contraindication | 82271004 | |
Constrictive pericarditis | contraindication | 85598007 | DOID:11481 |
Hypertrophic cardiomyopathy | contraindication | 233873004 | DOID:11984 |
Anemia | contraindication | 271737000 | DOID:2355 |
Cerebral hemorrhage | contraindication | 274100004 | |
Restrictive cardiomyopathy | contraindication | 415295002 | DOID:397 |
None
None
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
0.4MG/SPRAY | NITROLINGUAL PUMPSPRAY | POHL BOSKAMP | N018705 | Jan. 10, 1997 | RX | SPRAY, METERED | SUBLINGUAL | 7872049 | March 12, 2029 | METHOD OF TREATING ANGINA PECTORIS |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Soluble guanylate cyclase | Enzyme | ACTIVATOR | CHEMBL | CHEMBL | |||||
Atrial natriuretic peptide receptor 1 | Enzyme | WOMBAT-PK |
ID | Source |
---|---|
4017525 | VUID |
N0000145909 | NUI |
D00515 | KEGG_DRUG |
4017525 | VANDF |
CHEBI:28787 | CHEBI |
TNG | PDB_CHEM_ID |
CHEMBL730 | ChEMBL_ID |
7053 | IUPHAR_LIGAND_ID |
DB00727 | DRUGBANK_ID |
G59M7S0WS3 | UNII |
4510 | PUBCHEM_CID |
4917 | RXNORM |
2324 | MMSL |
5183 | MMSL |
d00321 | MMSL |
000683 | NDDF |
387404004 | SNOMEDCT_US |
71759000 | SNOMEDCT_US |
D005996 | MESH_DESCRIPTOR_UI |
C0017887 | UMLSCUI |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Nitrostat | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0417 | TABLET | 0.30 mg | SUBLINGUAL | NDA | 26 sections |
Nitrostat | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0418 | TABLET | 0.40 mg | SUBLINGUAL | NDA | 26 sections |
Nitrostat | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0419 | TABLET | 0.60 mg | SUBLINGUAL | NDA | 26 sections |
Cyclease Menopause | HUMAN OTC DRUG LABEL | 5 | 0220-9082 | TABLET | 4 [hp_C] | ORAL | unapproved homeopathic | 10 sections |
NITRO-BID | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0281-0326 | OINTMENT | 20 mg | TOPICAL | ANDA | 21 sections |
Nitroglycerin In Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-1047 | INJECTION | 10 mg | INTRAVENOUS | NDA | 20 sections |
Nitroglycerin In Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-1049 | INJECTION | 20 mg | INTRAVENOUS | NDA | 20 sections |
Nitroglycerin In Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-1051 | INJECTION | 40 mg | INTRAVENOUS | NDA | 20 sections |
Nitroglycerin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-9102 | PATCH | 0.10 mg | TRANSDERMAL | ANDA | 21 sections |
Nitroglycerin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-9104 | PATCH | 0.20 mg | TRANSDERMAL | ANDA | 21 sections |
Nitroglycerin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-9112 | PATCH | 0.40 mg | TRANSDERMAL | ANDA | 21 sections |
Nitroglycerin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-9116 | PATCH | 0.60 mg | TRANSDERMAL | ANDA | 21 sections |
Nitroglycerin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9928 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 11 sections |
NITROSTAT | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9929 | TABLET | 0.40 mg | SUBLINGUAL | NDA | 16 sections |
Nitroglycerin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0517-4810 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 21 sections |
Nitro-Time | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-0643 | CAPSULE | 2.50 mg | ORAL | Unapproved drug other | 22 sections |
Nitro-Time | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-0644 | CAPSULE | 6.50 mg | ORAL | Unapproved drug other | 22 sections |
Nitro-Time | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-0647 | CAPSULE | 9 mg | ORAL | Unapproved drug other | 22 sections |
Nitroglycerin Transdermal System | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5495 | PATCH | 0.20 mg | TRANSDERMAL | ANDA | 18 sections |
Nitroglycerin Transdermal System | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5496 | PATCH | 0.40 mg | TRANSDERMAL | ANDA | 18 sections |
Nitroglycerin Transdermal System | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5497 | PATCH | 0.60 mg | TRANSDERMAL | ANDA | 18 sections |
Nitrostat | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-450 | TABLET | 0.40 mg | SUBLINGUAL | NDA | 23 sections |
Nitroglycerin Slocaps | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-635 | CAPSULE | 2.50 mg | ORAL | Unapproved drug other | 19 sections |
Nitroglycerin Slocaps | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-636 | CAPSULE | 6.50 mg | ORAL | Unapproved drug other | 19 sections |
Nitroglycerin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-810 | TABLET | 0.40 mg | ORAL | Unapproved drug other | 23 sections |
NITROGLYCERIN LINGUAL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 28595-120 | SPRAY | 400 ug | ORAL | NDA | 26 sections |
NITROLINGUAL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 28595-550 | SPRAY | 400 ug | ORAL | NDA | 26 sections |
GONITRO | HUMAN PRESCRIPTION DRUG LABEL | 1 | 28595-705 | POWDER | 400 ug | SUBLINGUAL | NDA | 26 sections |
Minitran | HUMAN PRESCRIPTION DRUG LABEL | 1 | 29336-301 | PATCH | 2.50 mg | TRANSDERMAL | ANDA | 21 sections |
Minitran | HUMAN PRESCRIPTION DRUG LABEL | 1 | 29336-302 | PATCH | 5 mg | TRANSDERMAL | ANDA | 21 sections |