glyceryl trinitrate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
NO2 - derivatives	1952	55-63-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: nitroglycerin nitroglycerine nitroglycerol propanetriol trinitrate trinitroglycerin trinitroglycerol glyceryl trinitrate	A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives. Molecular weight: 227.09 Formula: C3H5N3O9 CLOGP: -5.76 LIPINSKI: 1 HAC: 12 HDO: 0 TPSA: 165.15 ALOGS: -3.05 ROTB: 8 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
5	mg	O
2.50	mg	oral aerosol
2.50	mg	SL
5	mg	TD

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.80 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	1.64 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	1 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance)	194.30 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.40 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	4.50 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
May 28, 1981	FDA	FOUGERA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Myocardial infarction	826.35	10.33	795	57146	96733	46531388
Coronary artery disease	389.62	10.33	328	57613	33424	46594697
Angina pectoris	350.53	10.33	280	57661	26495	46601626
Cardiac failure congestive	338.72	10.33	489	57452	91261	46536860
Acute myocardial infarction	325.43	10.33	289	57652	31635	46596486
Chest pain	319.69	10.33	687	57254	175637	46452484
Orthostatic hypotension	210.07	10.33	202	57739	24456	46603665
Angina unstable	208.37	10.33	125	57816	7423	46620698
Sedation complication	148.67	10.33	78	57863	3567	46624554
Renal failure	144.29	10.33	386	57555	113208	46514913
Coronary arterial stent insertion	130.65	10.33	66	57875	2787	46625334
Renal injury	127.41	10.33	101	57840	9440	46618681
Creatinine renal clearance decreased	125.41	10.33	88	57853	6832	46621289
Acute coronary syndrome	119.37	10.33	100	57841	10104	46618017
Fear	114.75	10.33	120	57821	16052	46612069
Rheumatoid arthritis	110.69	10.33	82	57859	240133	46387988
Injury	101.59	10.33	190	57751	43837	46584284
Hypotension	97.09	10.33	555	57386	232034	46396087
Bradycardia	96.22	10.33	237	57704	66061	46562060
Anhedonia	90.52	10.33	86	57855	10249	46617872
Gastrointestinal haemorrhage	90.29	10.33	255	57686	77118	46551003
Off label use	87.40	10.33	216	57725	379625	46248496
Drug ineffective	85.32	10.33	494	57447	677344	45950777
Sedation	82.74	10.33	121	57820	22789	46605332
Cerebrovascular accident	82.16	10.33	294	57647	100745	46527376
Blood calcium decreased	81.60	10.33	99	57842	15574	46612547
Emotional distress	80.36	10.33	140	57801	30567	46597554
Coronary artery occlusion	77.86	10.33	71	57870	8031	46620090
Fall	73.16	10.33	675	57266	328422	46299699
Labile blood pressure	71.04	10.33	37	57904	1666	46626455
Myocardial ischaemia	68.77	10.33	82	57859	12667	46615454
Balance disorder	66.04	10.33	203	57738	64318	46563803
Treatment failure	66.04	10.33	17	57924	93070	46535051
Cognitive disorder	63.48	10.33	141	57800	36742	46591379
Peripheral vascular disorder	62.63	10.33	55	57886	5922	46622199
Transient ischaemic attack	60.71	10.33	134	57807	34769	46593352
Cardiac disorder	60.68	10.33	154	57787	43704	46584417
Hyperkalaemia	59.99	10.33	168	57773	50541	46577580
Syncope	58.91	10.33	272	57669	104531	46523590
Atrial fibrillation	56.13	10.33	266	57675	103324	46524797
Febrile neutropenia	55.41	10.33	24	57917	94603	46533518
Unevaluable event	52.68	10.33	151	57790	46024	46582097
Neutropenia	50.55	10.33	62	57879	143142	46484979
Drug abuse	50.22	10.33	9	57932	63399	46564722
Pyrexia	48.17	10.33	246	57695	348556	46279565
Depressed level of consciousness	48.05	10.33	149	57792	47420	46580701
Maternal exposure during pregnancy	47.16	10.33	35	57906	102514	46525607
Cardiac failure	46.78	10.33	210	57731	79738	46548383
Renal impairment	46.28	10.33	199	57742	74173	46553948
Contraindicated product administered	45.66	10.33	21	57920	79926	46548195
Abortion spontaneous	42.51	10.33	3	57938	43643	46584478
Oesophageal spasm	42.48	10.33	28	57913	1961	46626160
Alopecia	42.43	10.33	86	57855	162328	46465793
Ischaemic cardiomyopathy	42.26	10.33	31	57910	2579	46625542
Acute kidney injury	39.54	10.33	457	57484	235398	46392723
Arteriospasm coronary	39.31	10.33	34	57907	3587	46624534
Troponin increased	38.47	10.33	48	57893	7768	46620353
Infusion related reaction	37.66	10.33	42	57899	101166	46526955
Hypoglycaemia	37.40	10.33	150	57791	54199	46573922
Coronary artery bypass	37.26	10.33	28	57913	2417	46625704
Intentional overdose	37.18	10.33	17	57924	64927	46563194
Chronic obstructive pulmonary disease	34.92	10.33	153	57788	57480	46570641
White blood cell count decreased	34.18	10.33	54	57887	112177	46515944
Bursitis infective	33.80	10.33	20	57921	1157	46626964
Arteriosclerosis coronary artery	33.77	10.33	46	57895	8110	46620011
Drug intolerance	33.41	10.33	84	57857	146965	46481156
Abdominal discomfort	33.08	10.33	88	57853	151077	46477044
Systemic lupus erythematosus	32.98	10.33	20	57921	65160	46562961
Pulmonary oedema	32.75	10.33	138	57803	50967	46577154
Injection site pain	32.21	10.33	52	57889	107100	46521021
Suicide attempt	32.14	10.33	14	57927	55022	46573099
Coronary artery stenosis	31.70	10.33	34	57907	4679	46623442
Cardiac arrest	31.45	10.33	206	57735	90193	46537928
Sinus arrest	31.33	10.33	22	57919	1709	46626412
Hyponatraemia	31.15	10.33	224	57717	101108	46527013
Prinzmetal angina	30.34	10.33	16	57925	739	46627382
Hepatic ischaemia	30.09	10.33	14	57927	492	46627629
Product dose omission issue	29.86	10.33	108	57833	168412	46459709
Cardiac murmur	29.83	10.33	52	57889	11352	46616769
Completed suicide	29.66	10.33	88	57853	145832	46482289
Dyspnoea	29.38	10.33	842	57099	514706	46113415
Sinus node dysfunction	28.95	10.33	31	57910	4258	46623863
Injection site pruritus	28.67	10.33	7	57934	39736	46588385
Product solubility abnormal	28.53	10.33	16	57925	836	46627285
Injection site reaction	28.21	10.33	12	57929	47837	46580284
Exposure during pregnancy	27.65	10.33	58	57883	108154	46519967
Injection site erythema	27.56	10.33	31	57910	74396	46553725
Muscle relaxant therapy	27.42	10.33	9	57932	120	46628001
Hand deformity	27.17	10.33	5	57936	34569	46593552
Lower gastrointestinal haemorrhage	26.91	10.33	39	57902	7281	46620840
Hyperkeratosis	26.57	10.33	32	57909	4993	46623128
Malignant neoplasm progression	26.35	10.33	25	57916	64901	46563220
Hepatic enzyme increased	26.20	10.33	38	57903	81749	46546372
Stress	26.18	10.33	130	57811	51421	46576700
Disease progression	25.88	10.33	46	57895	91254	46536867
Product use issue	25.66	10.33	49	57892	94595	46533526
Fear of eating	24.98	10.33	11	57930	339	46627782
Condition aggravated	24.86	10.33	190	57751	244862	46383259
Haemorrhage	24.84	10.33	134	57807	54735	46573386
Nasopharyngitis	24.52	10.33	103	57838	153895	46474226
International normalised ratio increased	24.36	10.33	119	57822	46764	46581357
Confusional state	23.78	10.33	303	57638	159589	46468532
Psoriasis	23.76	10.33	38	57903	78566	46549555
Hyperlipidaemia	23.48	10.33	63	57878	18476	46609645
Glossodynia	23.32	10.33	13	57928	44360	46583761
Left ventricular dysfunction	23.32	10.33	44	57897	10211	46617910
Coronary artery dissection	23.22	10.33	13	57928	677	46627444
Anxiety	23.04	10.33	335	57606	181622	46446499
Sinus bradycardia	22.93	10.33	52	57889	13730	46614391
Arthralgia	22.84	10.33	317	57624	364286	46263835
Infection	22.75	10.33	87	57854	133505	46494616
Angioplasty	22.69	10.33	16	57925	1251	46626870
Drug interaction	22.68	10.33	366	57575	202728	46425393
Haematemesis	22.68	10.33	83	57858	28723	46599398
Autonomic dysreflexia	22.65	10.33	9	57932	213	46627908
Mucosal inflammation	22.62	10.33	10	57931	38966	46589155
Joint swelling	22.37	10.33	118	57823	165955	46462166
Presyncope	22.32	10.33	74	57867	24380	46603741
Acute pulmonary oedema	21.98	10.33	37	57904	7854	46620267
Rash	21.97	10.33	311	57630	356201	46271920
Melaena	21.85	10.33	80	57861	27692	46600429
Diarrhoea	21.75	10.33	529	57412	559073	46069048
Cardiomegaly	21.73	10.33	59	57882	17423	46610698
Hepatorenal syndrome	21.73	10.33	18	57923	1790	46626331
Percutaneous coronary intervention	21.72	10.33	8	57933	153	46627968
Arterial occlusive disease	21.28	10.33	28	57913	4776	46623345
Arthropathy	21.13	10.33	46	57895	84654	46543467
Blood loss anaemia	21.07	10.33	38	57903	8519	46619602
Dermatitis bullous	20.19	10.33	35	57906	7608	46620513
Pituitary apoplexy	20.16	10.33	7	57934	112	46628009
Hypertension	19.78	10.33	348	57593	196008	46432113
Neutrophil count decreased	19.72	10.33	15	57926	43411	46584710
Chronic kidney disease	19.31	10.33	101	57840	40770	46587351
Atrioventricular block	19.06	10.33	32	57909	6779	46621342
Product use in unapproved indication	18.65	10.33	54	57887	90219	46537902
Colitis microscopic	18.61	10.33	31	57910	6525	46621596
Hypovolaemia	18.37	10.33	39	57902	9849	46618272
Therapeutic product effect decreased	18.12	10.33	48	57893	82553	46545568
Synovitis	18.01	10.33	30	57911	61045	46567076
Laryngotracheal oedema	17.99	10.33	5	57936	36	46628085
Ventricular tachycardia	17.92	10.33	54	57887	16913	46611208
Fatigue	17.90	10.33	598	57343	608099	46020022
Bundle branch block left	17.82	10.33	30	57911	6369	46621752
Duodenal ulcer	17.70	10.33	32	57909	7186	46620935
Device dislocation	17.47	10.33	3	57938	21799	46606322
Psoriatic arthropathy	17.26	10.33	12	57929	36367	46591754
Mitral valve incompetence	17.16	10.33	57	57884	18795	46609326
Leukopenia	17.14	10.33	37	57904	68306	46559815
Coronary artery reocclusion	17.11	10.33	5	57936	44	46628077
Electrocardiogram ST segment elevation	17.09	10.33	22	57919	3673	46624448
Silent myocardial infarction	16.81	10.33	9	57932	429	46627692
Coronary artery restenosis	16.79	10.33	9	57932	430	46627691
Sputum discoloured	16.77	10.33	44	57897	12734	46615387
Reperfusion arrhythmia	16.63	10.33	5	57936	49	46628072
Bone marrow failure	16.62	10.33	8	57933	29661	46598460
Lip swelling	16.60	10.33	69	57872	25326	46602795
Ventricular extrasystoles	16.51	10.33	40	57901	11023	46617098
Left ventricular end-diastolic pressure increased	16.47	10.33	8	57933	310	46627811
Laryngospasm	16.36	10.33	19	57922	2854	46625267
Rectal haemorrhage	16.36	10.33	92	57849	38163	46589958
Multiple organ dysfunction syndrome	16.28	10.33	115	57826	51595	46576526
Sinusitis	15.94	10.33	95	57846	129673	46498448
Swollen tongue	15.76	10.33	75	57866	29157	46598964
Generalised tonic-clonic seizure	15.67	10.33	7	57934	27115	46601006
Discoloured vomit	15.62	10.33	9	57932	495	46627626
Pancytopenia	15.39	10.33	54	57887	85004	46543117
Oedema peripheral	15.35	10.33	281	57660	159425	46468696
C-reactive protein increased	15.30	10.33	31	57910	58559	46569562
Bacteriuria	15.08	10.33	10	57931	707	46627414
Troponin T increased	14.97	10.33	11	57930	918	46627203
Neuropathy peripheral	14.95	10.33	60	57881	90833	46537288
Cardiac failure chronic	14.78	10.33	20	57921	3504	46624617
Injection site swelling	14.70	10.33	17	57924	40310	46587811
Pruritus	14.69	10.33	212	57729	242140	46385981
Intentional product use issue	14.59	10.33	27	57914	52753	46575368
Coronary ostial stenosis	14.57	10.33	5	57936	77	46628044
Herpes zoster	14.46	10.33	40	57901	67832	46560289
Erythema	14.34	10.33	111	57830	142709	46485412
Subdural haematoma	14.33	10.33	42	57899	12955	46615166
Heart injury	14.19	10.33	12	57929	1227	46626894
Catheterisation cardiac	14.07	10.33	21	57920	4026	46624095
Headache	14.02	10.33	470	57471	477882	46150239
Palmar-plantar erythrodysaesthesia syndrome	13.99	10.33	4	57937	20447	46607674
Haematoma	13.86	10.33	77	57864	31795	46596326
Ascites	13.80	10.33	15	57926	36569	46591552
Peripheral ischaemia	13.54	10.33	22	57919	4537	46623584
Musculoskeletal stiffness	13.53	10.33	69	57872	97924	46530197
Device issue	13.50	10.33	4	57937	19976	46608145
Cytomegalovirus infection	13.47	10.33	3	57938	18141	46609980
Acne	13.44	10.33	4	57937	19915	46608206
Arteriosclerosis	13.27	10.33	34	57907	9699	46618422
Mobility decreased	13.24	10.33	124	57817	60470	46567651
Oesophageal pain	13.13	10.33	16	57925	2527	46625594
Dyspnoea exertional	13.11	10.33	107	57834	50182	46577939
Vascular pseudoaneurysm	13.08	10.33	12	57929	1368	46626753
Systolic anterior motion of mitral valve	12.93	10.33	3	57938	9	46628112
Gastric haemorrhage	12.92	10.33	25	57916	5909	46622212
Finger amputation	12.69	10.33	8	57933	519	46627602
Ischaemia	12.66	10.33	21	57920	4403	46623718
Non-cardiac chest pain	12.50	10.33	25	57916	6053	46622068
Swelling	12.39	10.33	97	57844	124414	46503707
Knee arthroplasty	12.34	10.33	7	57934	23658	46604463
Atrioventricular block second degree	12.20	10.33	19	57922	3780	46624341
Suicidal ideation	12.18	10.33	33	57908	56349	46571772
Femur fracture	12.03	10.33	17	57924	36980	46591141
Therapeutic response decreased	11.99	10.33	22	57919	43123	46584998
Inappropriate schedule of product administration	11.94	10.33	41	57900	64972	46563149
Discomfort	11.93	10.33	25	57916	46645	46581476
Vascular graft	11.91	10.33	9	57932	783	46627338
Periorbital haematoma	11.90	10.33	9	57932	784	46627337
Arterial intramural haematoma	11.89	10.33	3	57938	14	46628107
Arteriogram coronary abnormal	11.89	10.33	3	57938	14	46628107
Cardiogenic shock	11.89	10.33	46	57895	16338	46611783
No adverse event	11.87	10.33	15	57926	34216	46593905
Throat irritation	11.87	10.33	11	57930	28890	46599231
Mitral valve calcification	11.84	10.33	10	57931	1021	46627100
Essential hypertension	11.73	10.33	20	57921	4290	46623831
Stent placement	11.72	10.33	18	57923	3538	46624583
Medication error	11.70	10.33	72	57869	30839	46597282
Flushing	11.70	10.33	41	57900	64573	46563548
Lupus myocarditis	11.70	10.33	4	57937	61	46628060
Acquired epidermolysis bullosa	11.64	10.33	4	57937	62	46628059
Hospitalisation	11.63	10.33	40	57901	63345	46564776
Red blood cell sedimentation rate increased	11.61	10.33	7	57934	22882	46605239
Drug eruption	11.57	10.33	6	57935	21323	46606798
Reflux gastritis	11.57	10.33	9	57932	818	46627303
Cardiomyopathy	11.56	10.33	45	57896	16028	46612093
Hyperhidrosis	11.51	10.33	165	57776	89143	46538978
Nephrogenic systemic fibrosis	11.51	10.33	21	57920	4751	46623370
Constipation	11.46	10.33	290	57651	173807	46454314
Colitis ischaemic	11.42	10.33	33	57908	10099	46618022
Hypertensive heart disease	11.38	10.33	15	57926	2563	46625558
Platelet count decreased	11.37	10.33	75	57866	99949	46528172
Lethargy	11.32	10.33	105	57836	51066	46577055
Sepsis	11.30	10.33	111	57830	135903	46492218
Lymphadenopathy	11.28	10.33	15	57926	33473	46594648
Total lung capacity decreased	11.21	10.33	10	57931	1099	46627022
Multiple injuries	11.17	10.33	13	57928	1956	46626165
Breast cancer	11.12	10.33	25	57916	45493	46582628
Acute myeloid leukaemia	10.96	10.33	3	57938	15775	46612346
Electrocardiogram T wave abnormal	10.90	10.33	14	57927	2332	46625789
Nodal rhythm	10.83	10.33	12	57929	1713	46626408
Therapeutic product effect incomplete	10.81	10.33	55	57886	78098	46550023
Coronary artery thrombosis	10.79	10.33	10	57931	1155	46626966
Ventricular hypertrophy	10.78	10.33	18	57923	3796	46624325
Cardioactive drug level increased	10.70	10.33	13	57928	2046	46626075
Leg amputation	10.68	10.33	13	57928	2050	46626071
Patent ductus arteriosus	10.61	10.33	18	57923	3844	46624277
Coagulation time abnormal	10.56	10.33	4	57937	83	46628038
Stridor	10.47	10.33	16	57925	3131	46624990
Mental status changes	10.45	10.33	82	57859	38006	46590115
Hypoosmolar state	10.36	10.33	5	57936	191	46627930
Cardiac arrest neonatal	10.34	10.33	4	57937	88	46628033

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Myocardial infarction	884.59	10.88	1140	56010	124485	29770843
Chest pain	435.24	10.88	793	56357	116834	29778494
Coronary artery disease	405.91	10.88	487	56663	49225	29846103
Angina pectoris	393.16	10.88	375	56775	29143	29866185
Acute myocardial infarction	370.39	10.88	480	56670	52459	29842869
Cardiac failure congestive	316.78	10.88	573	56577	83834	29811494
Injury	212.73	10.88	234	56916	21497	29873831
Fear	209.19	10.88	170	56980	10655	29884673
Angina unstable	208.23	10.88	179	56971	12131	29883197
Coronary arterial stent insertion	178.55	10.88	107	57043	4087	29891241
Anhedonia	177.88	10.88	139	57011	8230	29887098
Renal injury	152.21	10.88	147	57003	11582	29883746
Emotional distress	146.08	10.88	165	56985	15600	29879728
Drug abuse	128.04	10.88	7	57143	82065	29813263
Stress	110.51	10.88	163	56987	20072	29875256
Hypotension	108.12	10.88	703	56447	199862	29695466
Bradycardia	103.28	10.88	317	56833	65209	29830119
Product solubility abnormal	102.65	10.88	39	57111	517	29894811
Unevaluable event	93.55	10.88	195	56955	31590	29863738
Ischaemic cardiomyopathy	87.55	10.88	82	57068	6215	29889113
Off label use	85.82	10.88	221	56929	249069	29646259
Syncope	85.05	10.88	354	56796	84549	29810779
Toxicity to various agents	77.68	10.88	137	57013	177046	29718282
Cardiac disorder	75.36	10.88	206	56944	39687	29855641
Anxiety	72.20	10.88	351	56799	89520	29805808
Myocardial ischaemia	71.79	10.88	123	57027	17194	29878134
Dizziness	70.36	10.88	622	56528	194287	29701041
Coronary artery bypass	69.43	10.88	66	57084	5096	29890232
Pyrexia	66.30	10.88	313	56837	294176	29601152
Presyncope	57.51	10.88	107	57043	15949	29879379
Completed suicide	57.48	10.88	63	57087	99429	29795899
Neutropenia	56.63	10.88	99	57051	128441	29766887
Acute coronary syndrome	55.72	10.88	96	57054	13477	29881851
Coronary artery occlusion	54.01	10.88	85	57065	11072	29884256
Ventricular extrasystoles	52.23	10.88	85	57065	11389	29883939
Ventricular fibrillation	51.88	10.88	99	57051	15039	29880289
Febrile neutropenia	49.93	10.88	79	57071	106614	29788714
Ventricular tachycardia	49.90	10.88	128	57022	23734	29871594
Foetal exposure during pregnancy	49.62	10.88	6	57144	36865	29858463
Cerebrovascular accident	47.50	10.88	297	56853	83180	29812148
Coronary artery stenosis	46.56	10.88	71	57079	8999	29886329
Product use in unapproved indication	45.57	10.88	44	57106	73649	29821679
Atrial fibrillation	44.73	10.88	356	56794	107768	29787560
Renal failure	43.59	10.88	406	56744	128560	29766768
Chronic obstructive pulmonary disease	43.55	10.88	189	56961	45937	29849391
Pain	40.88	10.88	506	56644	172135	29723193
Dyspnoea	38.76	10.88	869	56281	332426	29562902
Malignant neoplasm progression	38.29	10.88	49	57101	72238	29823090
Chest discomfort	36.73	10.88	178	56972	45302	29850026
Arteriosclerosis coronary artery	35.75	10.88	71	57079	11105	29884223
Gastrointestinal haemorrhage	35.17	10.88	276	56874	83170	29812158
C-reactive protein increased	33.13	10.88	21	57129	43452	29851876
International normalised ratio increased	31.08	10.88	176	56974	47563	29847765
Prinzmetal angina	30.24	10.88	20	57130	909	29894419
Diarrhoea	29.34	10.88	455	56695	333648	29561680
Drug reaction with eosinophilia and systemic symptoms	29.19	10.88	9	57141	28479	29866849
Therapeutic product effect incomplete	29.18	10.88	14	57136	33820	29861508
Cardiac failure	28.85	10.88	264	56886	83154	29812174
Leukopenia	27.78	10.88	40	57110	56119	29839209
Drug ineffective	27.74	10.88	470	56680	339917	29555411
Hepatic function abnormal	27.16	10.88	24	57126	41921	29853407
Cytomegalovirus infection	27.07	10.88	6	57144	23668	29871660
Troponin increased	26.82	10.88	55	57095	8802	29886526
Cerebral artery thrombosis	26.71	10.88	15	57135	506	29894822
Rash	26.64	10.88	236	56914	191653	29703675
Middle insomnia	26.59	10.88	43	57107	5730	29889598
Hyperlipidaemia	25.43	10.88	71	57079	13836	29881492
Base excess decreased	24.92	10.88	11	57139	218	29895110
Acute kidney injury	24.62	10.88	690	56460	273152	29622176
Electrocardiogram ST segment elevation	24.55	10.88	36	57114	4406	29890922
Mucosal inflammation	24.26	10.88	14	57136	30480	29864848
Orthostatic hypotension	23.97	10.88	100	57050	23879	29871449
Post procedural complication	23.58	10.88	62	57088	11664	29883664
Product dose omission issue	23.19	10.88	93	57057	91538	29803790
Vascular stent occlusion	22.99	10.88	9	57141	130	29895198
Coronary artery thrombosis	22.37	10.88	24	57126	2140	29893188
Neutrophil count decreased	22.24	10.88	29	57121	42425	29852903
Renal impairment	21.74	10.88	251	56899	83933	29811395
White blood cell count decreased	21.37	10.88	85	57065	83862	29811466
Brain scan abnormal	21.12	10.88	14	57136	639	29894689
Neuroleptic malignant syndrome	21.08	10.88	3	57147	16292	29879036
Infusion related reaction	20.95	10.88	28	57122	40536	29854792
Oxygen consumption decreased	20.79	10.88	9	57141	170	29895158
Bone marrow failure	20.57	10.88	16	57134	29769	29865559
Pulmonary oedema	20.51	10.88	149	57001	43826	29851502
Arteriosclerosis	20.50	10.88	56	57094	10777	29884551
Laryngeal haematoma	20.34	10.88	8	57142	117	29895211
Peripheral vascular disorder	20.23	10.88	36	57114	5183	29890145
Reperfusion arrhythmia	20.11	10.88	7	57143	71	29895257
Intentional product misuse	19.95	10.88	22	57128	34645	29860683
Orthopnoea	19.81	10.88	33	57117	4507	29890821
Overdose	19.25	10.88	89	57061	84248	29811080
Rectal haemorrhage	19.03	10.88	123	57027	34816	29860512
Cardiac arrest	18.94	10.88	265	56885	92585	29802743
Rheumatoid arthritis	18.78	10.88	31	57119	41166	29854162
Arteriospasm coronary	18.67	10.88	24	57126	2594	29892734
Circulatory collapse	18.44	10.88	82	57068	20132	29875196
Supraventricular tachycardia	18.35	10.88	52	57098	10220	29885108
Pneumocystis jirovecii pneumonia	18.29	10.88	5	57145	17115	29878213
International normalised ratio decreased	18.23	10.88	32	57118	4558	29890770
Post procedural haemorrhage	18.18	10.88	44	57106	7866	29887462
Blood loss anaemia	18.15	10.88	43	57107	7584	29887744
Sinus bradycardia	17.85	10.88	56	57094	11639	29883689
Treatment failure	17.84	10.88	24	57126	34655	29860673
Infection	17.46	10.88	83	57067	77991	29817337
Platelet count decreased	17.25	10.88	125	57025	106004	29789324
Cardiac arrest neonatal	17.09	10.88	5	57145	27	29895301
Discharge	17.06	10.88	7	57143	115	29895213
Stomatitis	17.04	10.88	28	57122	37251	29858077
Non-cardiac chest pain	16.80	10.88	29	57121	4075	29891253
Carotid artery stenosis	16.64	10.88	31	57119	4623	29890705
Alanine aminotransferase increased	16.59	10.88	79	57071	74197	29821131
Vascular graft	16.58	10.88	17	57133	1438	29893890
Mitral valve incompetence	16.33	10.88	59	57091	13175	29882153
Atrial flutter	16.23	10.88	62	57088	14219	29881109
Normochromic normocytic anaemia	16.19	10.88	28	57122	3942	29891386
Heart rate decreased	15.41	10.88	80	57070	20914	29874414
Gastrointestinal tract irritation	15.25	10.88	8	57142	235	29895093
Coagulation time prolonged	15.13	10.88	15	57135	1219	29894109
Ventricular dysfunction	15.13	10.88	26	57124	3641	29891687
Death	15.12	10.88	544	56606	356739	29538589
Vascular graft occlusion	15.04	10.88	11	57139	589	29894739
Osteonecrosis	14.98	10.88	6	57144	16129	29879199
Cervicogenic headache	14.85	10.88	4	57146	15	29895313
Cardiac procedure complication	14.77	10.88	8	57142	251	29895077
Chronic kidney disease	14.75	10.88	123	57027	37715	29857613
Nerve degeneration	14.75	10.88	7	57143	165	29895163
Ecchymosis	14.69	10.88	36	57114	6486	29888842
Disease progression	14.51	10.88	91	57059	79783	29815545
Intentional overdose	14.03	10.88	37	57113	41444	29853884
Sepsis	13.95	10.88	196	56954	146199	29749129
Decreased appetite	13.83	10.88	202	56948	149708	29745620
Neurotoxicity	13.80	10.88	4	57146	13178	29882150
Multiple injuries	13.69	10.88	18	57132	1989	29893339
Seizure	13.68	10.88	121	57029	98354	29796974
Arterial spasm	13.45	10.88	6	57144	122	29895206
Interstitial lung disease	13.45	10.88	64	57086	60133	29835195
Acute myeloid leukaemia	13.31	10.88	9	57141	17997	29877331
Stent placement	13.28	10.88	28	57122	4568	29890760
Swollen tongue	13.17	10.88	55	57095	13137	29882191
Psychotic disorder	13.11	10.88	13	57137	21502	29873826
Hyperhidrosis	13.08	10.88	190	56960	66900	29828428
Poor quality product administered	13.02	10.88	16	57134	1653	29893675
Left ventricular enlargement	12.97	10.88	10	57140	580	29894748
Tricuspid valve incompetence	12.89	10.88	41	57109	8582	29886746
Generalised tonic-clonic seizure	12.88	10.88	11	57139	19540	29875788
Hypertrophy	12.86	10.88	8	57142	327	29895001
Hiatus hernia	12.77	10.88	36	57114	7054	29888274
Hepatocellular injury	12.73	10.88	18	57132	25453	29869875
Haematuria	12.62	10.88	136	57014	44698	29850630
Intentional self-injury	12.62	10.88	5	57145	13527	29881801
Cardiomegaly	12.59	10.88	58	57092	14451	29880877
Cold sweat	12.52	10.88	42	57108	9040	29886288
Morning glory syndrome	12.51	10.88	3	57147	6	29895322
Arrhythmia	12.50	10.88	107	57043	33062	29862266
Organ failure	12.46	10.88	18	57132	2173	29893155
Drug resistance	12.46	10.88	12	57138	20121	29875207
Acute pulmonary oedema	12.42	10.88	37	57113	7478	29887850
Myocardial necrosis marker increased	12.23	10.88	15	57135	1546	29893782
Brain natriuretic peptide increased	12.15	10.88	25	57125	4010	29891318
Ventricular asystole	12.10	10.88	6	57144	156	29895172
Coronary ostial stenosis	12.03	10.88	5	57145	85	29895243
Coronary artery restenosis	12.02	10.88	13	57137	1170	29894158
Mean cell haemoglobin decreased	11.89	10.88	13	57137	1184	29894144
Melaena	11.89	10.88	104	57046	32333	29862995
Hyperbilirubinaemia	11.82	10.88	9	57141	16933	29878395
Palmar-plantar erythrodysaesthesia syndrome	11.58	10.88	7	57143	14863	29880465
Respiratory arrest	11.57	10.88	24	57126	29234	29866094
Pneumonia	11.55	10.88	521	56629	333785	29561543
Ureteral disorder	11.41	10.88	6	57144	177	29895151
Transaminases increased	11.31	10.88	17	57133	23440	29871888
Haemorrhage	11.27	10.88	136	57014	45943	29849385
Blood count abnormal	11.18	10.88	48	57102	11604	29883724
Ventricular arrhythmia	11.11	10.88	25	57125	4263	29891065
Injection site pain	11.06	10.88	26	57124	30284	29865044
Myocardial depression	11.04	10.88	4	57146	46	29895282
Blood creatine phosphokinase MB increased	11.02	10.88	16	57134	1940	29893388
Hyperkalaemia	10.98	10.88	182	56968	65828	29829500
Product complaint	10.97	10.88	30	57120	5776	29889552

Pharmacologic Action:

Source	Code	Description
ATC	C01DA02	CARDIOVASCULAR SYSTEM CARDIAC THERAPY VASODILATORS USED IN CARDIAC DISEASES Organic nitrates
ATC	C01DA52	CARDIOVASCULAR SYSTEM CARDIAC THERAPY VASODILATORS USED IN CARDIAC DISEASES Organic nitrates
ATC	C05AE01	CARDIOVASCULAR SYSTEM VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Muscle relaxants
FDA CS	M0014874	Nitrates
FDA PE	N0000009909	Vasodilation
FDA EPC	N0000175415	Nitrate Vasodilator
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D053834	Explosive Agents
MeSH PA	D014665	Vasodilator Agents
CHEBI has role	CHEBI:35620	vasodilator
CHEBI has role	CHEBI:35703	xenobiotic
CHEBI has role	CHEBI:50266	prodrugs
CHEBI has role	CHEBI:50566	nitric oxide releasing agent
CHEBI has role	CHEBI:51371	muscle relaxants
CHEBI has role	CHEBI:63490	explosive material
CHEBI has role	CHEBI:66993	anti-contraction drug

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Angina pectoris	indication	194828000
Left ventricular cardiac dysfunction	indication	429589006
Perioperative hypertension	indication	434711000124103
Angina Pectoris Prevention	indication
Myocardial infarction	off-label use	22298006	DOID:5844
Anal fissure	off-label use	30037006
Decompensated cardiac failure	off-label use	195111005
Extravasation injury	off-label use	371100002
Acute coronary syndrome	off-label use	394659003
Hypertensive urgency	off-label use	443482000
Hypovolemia	contraindication	28560003
Cardiac tamponade	contraindication	35304003	DOID:115
Methemoglobinemia	contraindication	38959009	DOID:10783
Low blood pressure	contraindication	45007003
Chronic heart failure	contraindication	48447003
Injury of head	contraindication	82271004
Constrictive pericarditis	contraindication	85598007	DOID:11481
Hypertrophic cardiomyopathy	contraindication	233873004	DOID:11984
Anemia	contraindication	271737000	DOID:2355
Cerebral hemorrhage	contraindication	274100004
Restrictive cardiomyopathy	contraindication	415295002	DOID:397

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Soluble guanylate cyclase	Enzyme	O75343 P33402 Q02108 Q02153	GCYA2_HUMAN GCYA3_HUMAN GCYB1_HUMAN GCYB2_HUMAN	ACTIVATOR				CHEMBL	CHEMBL
Atrial natriuretic peptide receptor 1	Enzyme	P16066	ANPRA_HUMAN					WOMBAT-PK

External reference:

ID	Source
4017525	VUID
N0000145909	NUI
D00515	KEGG_DRUG
4017525	VANDF
C0017887	UMLSCUI
CHEBI:28787	CHEBI
TNG	PDB_CHEM_ID
CHEMBL730	ChEMBL_ID
DB00727	DRUGBANK_ID
D005996	MESH_DESCRIPTOR_UI
7053	IUPHAR_LIGAND_ID
G59M7S0WS3	UNII
4510	PUBCHEM_CID
4917	RXNORM
2324	MMSL
5183	MMSL
d00321	MMSL
000683	NDDF
387404004	SNOMEDCT_US
71759000	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Nitrostat	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0417	TABLET	0.30 mg	SUBLINGUAL	NDA	26 sections
Nitrostat	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0418	TABLET	0.40 mg	SUBLINGUAL	NDA	26 sections
Nitrostat	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0419	TABLET	0.60 mg	SUBLINGUAL	NDA	26 sections
Cyclease Menopause	HUMAN OTC DRUG LABEL	5	0220-9082	TABLET	4 [hp_C]	ORAL	unapproved homeopathic	10 sections
NITRO-BID	HUMAN PRESCRIPTION DRUG LABEL	1	0281-0326	OINTMENT	20 mg	TOPICAL	ANDA	21 sections
Nitroglycerin In Dextrose	HUMAN PRESCRIPTION DRUG LABEL	1	0338-1047	INJECTION	10 mg	INTRAVENOUS	NDA	20 sections
Nitroglycerin In Dextrose	HUMAN PRESCRIPTION DRUG LABEL	1	0338-1049	INJECTION	20 mg	INTRAVENOUS	NDA	20 sections
Nitroglycerin In Dextrose	HUMAN PRESCRIPTION DRUG LABEL	1	0338-1051	INJECTION	40 mg	INTRAVENOUS	NDA	20 sections
Nitroglycerin	HUMAN PRESCRIPTION DRUG LABEL	1	0378-9102	PATCH	0.10 mg	TRANSDERMAL	ANDA	21 sections
Nitroglycerin	HUMAN PRESCRIPTION DRUG LABEL	1	0378-9104	PATCH	0.20 mg	TRANSDERMAL	ANDA	21 sections
Nitroglycerin	HUMAN PRESCRIPTION DRUG LABEL	1	0378-9112	PATCH	0.40 mg	TRANSDERMAL	ANDA	21 sections
Nitroglycerin	HUMAN PRESCRIPTION DRUG LABEL	1	0378-9116	PATCH	0.60 mg	TRANSDERMAL	ANDA	21 sections
Nitroglycerin	HUMAN PRESCRIPTION DRUG LABEL	1	0517-4810	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	21 sections
Nitro-Time	HUMAN PRESCRIPTION DRUG LABEL	1	0904-0643	CAPSULE	2.50 mg	ORAL	Unapproved drug other	22 sections
Nitro-Time	HUMAN PRESCRIPTION DRUG LABEL	1	0904-0644	CAPSULE	6.50 mg	ORAL	Unapproved drug other	22 sections
Nitro-Time	HUMAN PRESCRIPTION DRUG LABEL	1	0904-0647	CAPSULE	9 mg	ORAL	Unapproved drug other	22 sections
Nitroglycerin Transdermal System	HUMAN PRESCRIPTION DRUG LABEL	1	0904-5495	PATCH	0.20 mg	TRANSDERMAL	ANDA	18 sections
Nitroglycerin Transdermal System	HUMAN PRESCRIPTION DRUG LABEL	1	0904-5496	PATCH	0.40 mg	TRANSDERMAL	ANDA	18 sections
Nitroglycerin Transdermal System	HUMAN PRESCRIPTION DRUG LABEL	1	0904-5497	PATCH	0.60 mg	TRANSDERMAL	ANDA	18 sections
Nitrostat	HUMAN PRESCRIPTION DRUG LABEL	1	21695-450	TABLET	0.40 mg	SUBLINGUAL	NDA	23 sections
Nitroglycerin Slocaps	HUMAN PRESCRIPTION DRUG LABEL	1	21695-635	CAPSULE	2.50 mg	ORAL	Unapproved drug other	19 sections
Nitroglycerin Slocaps	HUMAN PRESCRIPTION DRUG LABEL	1	21695-636	CAPSULE	6.50 mg	ORAL	Unapproved drug other	19 sections
Nitroglycerin	HUMAN PRESCRIPTION DRUG LABEL	1	21695-810	TABLET	0.40 mg	ORAL	Unapproved drug other	23 sections
NITROGLYCERIN LINGUAL	HUMAN PRESCRIPTION DRUG LABEL	1	28595-120	SPRAY	400 ug	ORAL	NDA	26 sections
NITROLINGUAL	HUMAN PRESCRIPTION DRUG LABEL	1	28595-550	SPRAY	400 ug	ORAL	NDA	26 sections
GONITRO	HUMAN PRESCRIPTION DRUG LABEL	1	28595-705	POWDER	400 ug	SUBLINGUAL	NDA	26 sections
Minitran	HUMAN PRESCRIPTION DRUG LABEL	1	29336-301	PATCH	2.50 mg	TRANSDERMAL	ANDA	21 sections
Minitran	HUMAN PRESCRIPTION DRUG LABEL	1	29336-302	PATCH	5 mg	TRANSDERMAL	ANDA	21 sections
Minitran	HUMAN PRESCRIPTION DRUG LABEL	1	29336-303	PATCH	10 mg	TRANSDERMAL	ANDA	21 sections
Minitran	HUMAN PRESCRIPTION DRUG LABEL	1	29336-304	PATCH	15 mg	TRANSDERMAL	ANDA	21 sections