glyceryl trinitrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
NO2 - derivatives 1952 55-63-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nitroglycerin
  • nitroglycerine
  • nitroglycerol
  • propanetriol trinitrate
  • trinitroglycerin
  • trinitroglycerol
  • glyceryl trinitrate
A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
  • Molecular weight: 227.09
  • Formula: C3H5N3O9
  • CLOGP: 0.92
  • LIPINSKI: 1
  • HAC: 12
  • HDO: 0
  • TPSA: 165.15
  • ALOGS: -3.05
  • ROTB: 8
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
5 mg O
2.50 mg oral aerosol
2.50 mg SL
5 mg TD

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.80 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.64 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 0.50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance) 194.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.40 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 4.50 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FGFR1,FLT1,GRK2,GSK3B,IGF1R,IKBKB,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ZAP70 62
kinase-selectivity-class AURKA,AXL,BMX,BRAF,CDK1,CDK2,CDK4,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,GSK3B,IRAK1,MAP2K3,MAP2K6,MAPK1,MAPK7,MET,PIK3CB,PRKDC,SIK2,STK33,SYK,TEK,TTK,UHMK1 28
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
May 28, 1981 FDA FOUGERA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 1133.76 11.01 885 86226 105087 90436249
Orthostatic hypotension 927.86 11.01 549 86562 41278 90500058
Creatinine renal clearance decreased 809.62 11.01 385 86726 18514 90522822
Sedation complication 777.65 11.01 362 86749 16582 90524754
Blood calcium decreased 663.60 11.01 394 86717 29788 90511548
Sedation 593.39 11.01 438 86673 47733 90493603
Cognitive disorder 576.92 11.01 501 86610 68906 90472430
Coronary artery disease 538.30 11.01 359 86752 33264 90508072
Balance disorder 538.08 11.01 560 86551 96520 90444816
Cardiac failure congestive 498.63 11.01 542 86569 98152 90443184
Depressed level of consciousness 460.26 11.01 451 86660 72333 90469003
Constipation 435.36 11.01 882 86229 279513 90261823
Hypotension 434.06 11.01 962 86149 324435 90216901
Acute myocardial infarction 417.86 11.01 312 86799 34578 90506758
Angina pectoris 402.98 11.01 320 86791 38840 90502496
Fall 376.62 11.01 1166 85945 480644 90060692
Glossodynia 262.10 11.01 11 87100 321768 90219568
Hand deformity 260.10 11.01 5 87106 296357 90244979
Systemic lupus erythematosus 255.01 11.01 26 87085 361870 90179466
Chest pain 228.60 11.01 751 86360 318894 90222442
Angina unstable 221.70 11.01 117 86994 7026 90534310
Contraindicated product administered 220.42 11.01 25 87086 320114 90221222
Synovitis 203.10 11.01 36 87075 329716 90211620
Hepatic enzyme increased 198.49 11.01 51 87060 360685 90180651
Arthropathy 195.44 11.01 55 87056 366187 90175149
Maternal exposure during pregnancy 194.13 11.01 53 87058 360010 90181326
Treatment failure 191.99 11.01 31 87080 303897 90237439
Renal failure 191.00 11.01 402 86709 130605 90410731
Helicobacter infection 190.75 11.01 6 87105 226844 90314492
Duodenal ulcer perforation 189.20 11.01 5 87106 221283 90320053
Chronic sinusitis 187.96 11.01 167 86944 23635 90517701
Alopecia 180.48 11.01 128 86983 494943 90046393
Vaginal flatulence 178.62 11.01 125 86986 12513 90528823
Paraesthesia oral 172.29 11.01 181 86930 31478 90509858
Drug intolerance 168.07 11.01 112 86999 447479 90093857
Proctitis 166.22 11.01 129 86982 15130 90526206
Radiculopathy 164.66 11.01 139 86972 18366 90522970
Coronary arterial stent insertion 156.62 11.01 69 87042 2771 90538565
Female genital tract fistula 154.45 11.01 132 86979 17736 90523600
Gastrointestinal haemorrhage 151.85 11.01 294 86817 89954 90451382
Renal injury 151.06 11.01 104 87007 10139 90531197
Joint swelling 150.70 11.01 157 86954 503143 90038193
Psoriatic arthropathy 147.09 11.01 22 87089 228313 90313023
Discomfort 146.66 11.01 41 87070 274294 90267042
Vaginal discharge 144.69 11.01 132 86979 19332 90522004
Acute coronary syndrome 143.68 11.01 103 87008 10710 90530626
Macular degeneration 142.25 11.01 179 86932 37791 90503545
Transient ischaemic attack 142.20 11.01 191 86920 42985 90498351
Wound 139.94 11.01 58 87053 302922 90238414
Fear 138.00 11.01 120 86991 16502 90524834
Rales 136.96 11.01 117 86994 15710 90525626
Abdominal discomfort 136.13 11.01 155 86956 477173 90064163
Bronchopulmonary aspergillosis allergic 135.09 11.01 68 87043 3698 90537638
Pericarditis 134.31 11.01 46 87065 270105 90271231
Rheumatic fever 132.62 11.01 3 87108 153118 90388218
Rheumatoid arthritis 131.73 11.01 94 87017 362520 90178816
Swelling 130.81 11.01 126 86985 418932 90122404
Bradycardia 126.48 11.01 261 86850 83586 90457750
Irritable bowel syndrome 120.60 11.01 26 87085 207422 90333914
Therapeutic product effect decreased 120.54 11.01 58 87053 277513 90263823
Product use issue 120.51 11.01 85 87026 329834 90211502
Impaired healing 117.94 11.01 39 87072 234160 90307176
Toxicity to various agents 117.72 11.01 568 86543 287278 90254058
Coronary artery occlusion 117.15 11.01 83 87028 8471 90532865
Procedural pain 116.68 11.01 152 86959 33208 90508128
Hypersensitivity 114.70 11.01 162 86949 454515 90086821
Hyperkalaemia 114.64 11.01 216 86895 64748 90476588
Total lung capacity decreased 114.49 11.01 61 87050 3734 90537602
Cerebrovascular accident 111.29 11.01 315 86796 123218 90418118
Liver injury 110.84 11.01 16 87095 170551 90370785
Sputum discoloured 109.91 11.01 116 86995 20275 90521061
Lung opacity 106.98 11.01 69 87042 6033 90535303
Anhedonia 106.11 11.01 88 87023 11343 90529993
Haematochezia 103.74 11.01 218 86893 70695 90470641
Labile blood pressure 100.81 11.01 45 87066 1865 90539471
Dyspnoea 98 11.01 1283 85828 879672 89661664
Oral candidiasis 97.67 11.01 144 86967 35311 90506025
Creatinine renal clearance increased 96.91 11.01 52 87059 3229 90538107
Emotional distress 96.84 11.01 146 86965 36516 90504820
Rectal haemorrhage 96.04 11.01 232 86879 82512 90458824
Blood calcium increased 95.98 11.01 85 87026 11973 90529363
Blister 95.35 11.01 64 87047 254934 90286402
Ill-defined disorder 94.47 11.01 30 87081 184861 90356475
Infection 94.30 11.01 126 86985 361968 90179368
Peripheral vascular disorder 94.14 11.01 65 87046 6366 90534970
Anaemia 93.67 11.01 620 86491 352182 90189154
Myocardial ischaemia 91.74 11.01 88 87023 13726 90527610
Atrial fibrillation 88.29 11.01 306 86805 133305 90408031
Arteriospasm coronary 88.28 11.01 57 87054 4993 90536343
Haemoptysis 87.03 11.01 132 86979 33188 90508148
Rash 86.29 11.01 433 86678 795667 89745669
Off label use 85.66 11.01 665 86446 1101587 89439749
Drug interaction 84.67 11.01 504 86607 275949 90265387
Stomatitis 84.02 11.01 84 87027 274614 90266722
Condition aggravated 82.32 11.01 295 86816 595250 89946086
Nasopharyngitis 81.54 11.01 168 86943 406936 90134400
Lip dry 80.33 11.01 4 87107 100951 90440385
Intentional product use issue 80.32 11.01 55 87056 216837 90324499
Type 2 diabetes mellitus 80.11 11.01 48 87063 203196 90338140
Colitis 78.92 11.01 194 86917 69748 90471588
Acute kidney injury 77.86 11.01 551 86560 319836 90221500
Cardiac disorder 77.62 11.01 170 86941 56702 90484634
Cardiac arrest 76.11 11.01 248 86863 104687 90436649
Multiple drug therapy 75.78 11.01 59 87052 6950 90534386
Exposure during pregnancy 75.11 11.01 71 87040 238339 90302997
Facet joint syndrome 74.92 11.01 5 87106 98384 90442952
Ventricular tachycardia 74.86 11.01 105 87006 24603 90516733
Renal function test abnormal 74.44 11.01 59 87052 7132 90534204
Cardiac failure 71.66 11.01 250 86861 109246 90432090
Sinusitis 69.18 11.01 141 86970 342947 90198389
C-reactive protein increased 68.50 11.01 45 87066 181344 90359992
Unevaluable event 68.21 11.01 158 86953 54690 90486646
Syncope 67.89 11.01 280 86831 132383 90408953
Febrile neutropenia 67.32 11.01 34 87077 158315 90383021
Renal impairment 66.66 11.01 238 86873 105183 90436153
Prinzmetal angina 66.19 11.01 28 87083 1017 90540319
Blood cholesterol increased 65.45 11.01 62 87049 207950 90333386
Arthralgia 64.47 11.01 461 86650 778061 89763275
Heart sounds 63.75 11.01 28 87083 1116 90540220
Aspiration 63.63 11.01 77 87034 15616 90525720
Infusion related reaction 63.31 11.01 198 86913 416582 90124754
Chronic obstructive pulmonary disease 63.30 11.01 185 86926 73644 90467692
Hallucination 63.13 11.01 172 86939 65787 90475549
Obstructive airways disorder 62.68 11.01 99 87012 25770 90515566
Joint range of motion decreased 62.52 11.01 26 87085 135617 90405719
Ischaemic cardiomyopathy 62.37 11.01 36 87075 2577 90538759
Sleep disorder 62.34 11.01 59 87052 197971 90343365
Bronchiectasis 61.94 11.01 91 87020 22239 90519097
Prolonged expiration 61.22 11.01 28 87083 1229 90540107
Stress 59.58 11.01 193 86918 81202 90460134
Mobility decreased 59.01 11.01 428 86683 250306 90291030
Autoimmune disorder 58.14 11.01 4 87107 76740 90464596
Live birth 57.46 11.01 5 87106 79102 90462234
Grip strength decreased 57.16 11.01 10 87101 92566 90448770
Oesophageal pain 56.59 11.01 41 87070 4333 90537003
Gastrointestinal disorder 56.54 11.01 100 87011 256587 90284749
Drug ineffective 55.39 11.01 968 86143 1383330 89158006
Coronary artery bypass 55.11 11.01 32 87079 2317 90539019
Bursitis 54.87 11.01 29 87082 131625 90409711
Neutropenia 54.79 11.01 82 87029 224822 90316514
Weight increased 53.78 11.01 213 86898 417714 90123622
Hypovolaemia 53.70 11.01 63 87048 12368 90528968
Chest discomfort 53.59 11.01 269 86842 138096 90403240
Red blood cell sedimentation rate increased 53.06 11.01 8 87103 82587 90458749
Wound infection 53.04 11.01 18 87093 106384 90434952
Cardiomegaly 52.31 11.01 77 87034 18848 90522488
Pulmonary oedema 51.73 11.01 154 86957 61926 90479410
Prescribed overdose 51.37 11.01 15 87096 97610 90443726
Frequent bowel movements 51.06 11.01 145 86966 56790 90484546
Angioplasty 51.02 11.01 26 87085 1451 90539885
Hyponatraemia 49.88 11.01 257 86854 133281 90408055
Peripheral venous disease 49.82 11.01 10 87101 83911 90457425
Hepatic ischaemia 49.61 11.01 21 87090 764 90540572
Troponin increased 48.76 11.01 62 87049 13219 90528117
Epilepsy 48.37 11.01 10 87101 82196 90459140
Coronary artery stenosis 47.76 11.01 40 87071 5226 90536110
Inflammation 47.62 11.01 61 87050 178531 90362805
Hip arthroplasty 47.56 11.01 8 87103 76200 90465136
Fibromyalgia 46.65 11.01 79 87032 206190 90335146
Malaise 46.07 11.01 805 86306 585181 89956155
Colitis ulcerative 46.02 11.01 145 86966 60121 90481215
International normalised ratio increased 45.89 11.01 124 86987 47192 90494144
Blood creatinine increased 45.72 11.01 206 86905 101180 90440156
Arteriosclerosis coronary artery 45.42 11.01 51 87060 9552 90531784
Knee arthroplasty 45.22 11.01 12 87099 83170 90458166
Injection site reaction 45.17 11.01 16 87095 92064 90449272
Lip swelling 44.51 11.01 108 87003 38502 90502834
Gait inability 44.50 11.01 45 87066 146411 90394925
Lung disorder 44.47 11.01 47 87064 149836 90391500
Tinnitus 43.87 11.01 115 86996 42987 90498349
General physical health deterioration 43.78 11.01 184 86927 354931 90186405
Haematemesis 42.86 11.01 98 87013 33628 90507708
Pain 42.52 11.01 1255 85856 995086 89546250
Blood test abnormal 42.46 11.01 74 87037 20878 90520458
Urticaria 42.39 11.01 156 86955 312578 90228758
Mitral valve incompetence 42.37 11.01 77 87034 22447 90518889
Pregnancy 42.26 11.01 5 87106 62042 90479294
Hypoglycaemia 41.87 11.01 155 86956 69693 90471643
Taste disorder 41.82 11.01 5 87106 61541 90479795
Blepharospasm 41.68 11.01 3 87108 55442 90485894
Hypoaesthesia 41.12 11.01 159 86952 314051 90227285
Hepatorenal syndrome 40.51 11.01 25 87086 2023 90539313
Dyspnoea exertional 40.51 11.01 157 86954 72131 90469205
Foot deformity 40.15 11.01 5 87106 59646 90481690
Myelosuppression 40.00 11.01 3 87108 53588 90487748
Sciatica 39.85 11.01 24 87087 101358 90439978
Night sweats 39.77 11.01 39 87072 128727 90412609
Nail disorder 39.64 11.01 5 87106 59062 90482274
Muscle relaxant therapy 39.52 11.01 12 87099 161 90541175
Liver disorder 39.49 11.01 35 87076 121234 90420102
Left ventricle outflow tract obstruction 39.22 11.01 15 87096 417 90540919
Product solubility abnormal 38.86 11.01 19 87092 970 90540366
Feeling abnormal 38.47 11.01 284 86827 166951 90374385
Haemorrhage 38.33 11.01 150 86961 69219 90472117
Pleuritic pain 37.09 11.01 48 87063 10413 90530923
Sinus arrest 36.96 11.01 24 87087 2122 90539214
Sinus node dysfunction 36.93 11.01 35 87076 5377 90535959
Psoriasis 36.82 11.01 53 87058 147701 90393635
Hyperlipidaemia 36.51 11.01 73 87038 22843 90518493
Lower limb fracture 36.51 11.01 18 87093 84995 90456341
Palpitations 36.02 11.01 240 86871 136488 90404848
Malignant neoplasm progression 35.83 11.01 30 87081 106840 90434496
Intentional overdose 35.79 11.01 23 87088 93811 90447525
Disease progression 35.39 11.01 60 87051 156555 90384781
Abortion spontaneous 35.27 11.01 5 87106 54051 90487285
Hyperhidrosis 34.56 11.01 237 86874 136068 90405268
Hypercholesterolaemia 34.22 11.01 28 87083 100864 90440472
Chronic kidney disease 34.04 11.01 116 86995 50075 90491261
Carotid artery occlusion 34.03 11.01 36 87075 6306 90535030
Bursitis infective 33.92 11.01 20 87091 1490 90539846
Peripheral swelling 33.91 11.01 245 86866 412861 90128475
Ventricular extrasystoles 33.90 11.01 52 87059 13198 90528138
Prescribed underdose 33.58 11.01 15 87096 75004 90466332
Rhabdomyolysis 33.49 11.01 117 86994 51139 90490197
Hypoxia 33.31 11.01 148 86963 72251 90469085
Onychomadesis 33.15 11.01 3 87108 45995 90495341
Vascular stent stenosis 32.74 11.01 15 87096 661 90540675
Laryngitis 32.40 11.01 5 87106 50748 90490588
Lower gastrointestinal haemorrhage 31.84 11.01 41 87070 8851 90532485
Musculoskeletal stiffness 31.58 11.01 162 86949 296370 90244966
Hyperkeratosis 31.42 11.01 36 87075 6892 90534444
Electrocardiogram ST segment elevation 31.35 11.01 28 87083 3988 90537348
Subarachnoid haemorrhage 30.91 11.01 59 87052 17845 90523491
White blood cell count decreased 30.90 11.01 72 87039 167037 90374299
Cardiospasm 30.89 11.01 26 87085 3420 90537916
Suicide attempt 30.84 11.01 17 87094 75382 90465954
Post procedural haemorrhage 30.62 11.01 40 87071 8758 90532578
Palmoplantar keratoderma 30.49 11.01 26 87085 3481 90537855
Oedema peripheral 30.31 11.01 380 86731 257535 90283801
Ventricular hyperkinesia 30.29 11.01 8 87103 62 90541274
Obesity 30.28 11.01 34 87077 105473 90435863
Tremor 30.19 11.01 251 86860 152922 90388414
Sleep apnoea syndrome 29.59 11.01 82 87029 31665 90509671
Pulmonary mass 29.52 11.01 77 87034 28695 90512641
Blood loss anaemia 29.11 11.01 42 87069 10098 90531238
Vascular pseudoaneurysm 29.02 11.01 19 87092 1704 90539632
Respiration abnormal 28.96 11.01 37 87074 7926 90533410
Haematoma 28.94 11.01 93 87018 38955 90502381
Pruritus 28.67 11.01 358 86753 541167 90000169
Mucosal inflammation 28.28 11.01 10 87101 57615 90483721
Sinus bradycardia 28.21 11.01 55 87056 16897 90524439
Road traffic accident 27.42 11.01 38 87073 107588 90433748
Left ventricular dysfunction 27.40 11.01 50 87061 14619 90526717
Percutaneous coronary intervention 27.37 11.01 10 87101 244 90541092
Arteriosclerosis 26.94 11.01 42 87069 10811 90530525
Blood glucose increased 26.80 11.01 170 86941 95076 90446260
Injection site pain 26.70 11.01 82 87029 173617 90367719
Gastric ulcer 26.68 11.01 72 87039 27376 90513960
Depressive symptom 26.60 11.01 29 87082 5256 90536080
Presyncope 26.59 11.01 79 87032 31726 90509610
Melaena 25.90 11.01 83 87028 34714 90506622
Product use in unapproved indication 25.87 11.01 203 86908 336033 90205303
Multiple organ dysfunction syndrome 25.84 11.01 132 86979 68204 90473132
Therapeutic response decreased 25.66 11.01 29 87082 89700 90451636
Pyuria 25.47 11.01 19 87092 2100 90539236
Hypertensive crisis 25.22 11.01 54 87057 17730 90523606
Leukopenia 25.21 11.01 36 87075 100674 90440662
Sleep terror 25.14 11.01 26 87085 4438 90536898
Coeliac disease 25.09 11.01 6 87105 44604 90496732
Acute pulmonary oedema 25.08 11.01 38 87073 9542 90531794
Musculoskeletal pain 24.81 11.01 83 87028 171168 90370168
Dry mouth 24.80 11.01 92 87019 183967 90357369
Pruritus genital 24.69 11.01 26 87085 4532 90536804
Coronary artery restenosis 24.68 11.01 10 87101 325 90541011
Atrioventricular block 24.56 11.01 36 87075 8779 90532557
Cardiac murmur 24.38 11.01 54 87057 18140 90523196
Pneumococcal infection 24.13 11.01 15 87096 1230 90540106
Neutrophil count decreased 24.07 11.01 20 87091 71512 90469824
Cardiomyopathy 23.80 11.01 57 87054 20149 90521187
Silent myocardial infarction 23.75 11.01 10 87101 359 90540977
Lymphoedema 23.35 11.01 45 87066 13708 90527628
Oedema 23.31 11.01 106 87005 200189 90341147
Exostosis 23.19 11.01 11 87100 53123 90488213
Joint dislocation 23.18 11.01 7 87104 44575 90496761
Onychomycosis 23.15 11.01 4 87107 37372 90503964
Lupus-like syndrome 23.09 11.01 9 87102 48837 90492499
Drug-induced liver injury 22.89 11.01 32 87079 90286 90451050
Circulatory collapse 22.89 11.01 64 87047 24840 90516496
Tension headache 22.88 11.01 32 87079 7477 90533859
Immunisation 22.57 11.01 18 87093 2195 90539141
Therapy non-responder 22.11 11.01 63 87048 136641 90404695
Atrial tachycardia 22.05 11.01 28 87083 5962 90535374
Swollen tongue 21.94 11.01 95 87016 45861 90495475
Bundle branch block left 21.67 11.01 32 87079 7853 90533483
Adverse event 21.37 11.01 51 87060 117367 90423969
Fatigue 21.36 11.01 900 86211 1153123 89388213
Anxiety 21.29 11.01 417 86694 309355 90231981
Blood pressure decreased 21.27 11.01 134 86977 74761 90466575
Cerebral mass effect 21.05 11.01 13 87098 1053 90540283
Postoperative renal failure 20.85 11.01 7 87104 132 90541204
Injection site pruritus 20.80 11.01 13 87098 53821 90487515
Cough 20.63 11.01 482 86629 368480 90172856
Coagulopathy 20.57 11.01 59 87052 23230 90518106
Injection site erythema 20.23 11.01 40 87071 98462 90442874
Pituitary apoplexy 20.23 11.01 7 87104 145 90541191
Transaminases increased 20.20 11.01 80 87031 37112 90504224
Inappropriate schedule of product administration 20.16 11.01 75 87036 149858 90391478
Dehydration 20.13 11.01 280 86831 194167 90347169
Autonomic dysreflexia 20.07 11.01 9 87102 377 90540959
Coronary artery reocclusion 20.04 11.01 5 87106 30 90541306
Left ventricular hypertrophy 19.95 11.01 27 87084 6117 90535219
Lethargy 19.86 11.01 116 86995 63023 90478313
Haemorrhoidal haemorrhage 19.78 11.01 25 87086 5298 90536038
Nephrogenic systemic fibrosis 19.74 11.01 22 87089 4086 90537250
Coronary ostial stenosis 19.72 11.01 6 87105 81 90541255
Mitral valve calcification 19.66 11.01 13 87098 1185 90540151
Tricuspid valve incompetence 19.49 11.01 47 87064 16684 90524652
Appetite disorder 19.48 11.01 33 87078 9100 90532236
Joint stiffness 19.43 11.01 28 87083 78014 90463322
Finger deformity 19.36 11.01 4 87107 32893 90508443
Left ventricular end-diastolic pressure increased 19.32 11.01 9 87102 412 90540924
Laryngotracheal oedema 19.14 11.01 5 87106 37 90541299
Cardiac failure chronic 18.62 11.01 25 87086 5621 90535715
Subdural haematoma 18.59 11.01 46 87065 16599 90524737
Abdominal pain 18.59 11.01 505 86606 395216 90146120
Craniocervical syndrome 18.34 11.01 6 87105 104 90541232
Ischaemia 18.31 11.01 24 87087 5271 90536065
Mental status changes 18.09 11.01 88 87023 44591 90496745
Torsade de pointes 18.07 11.01 43 87068 15139 90526197
Cardiogenic shock 17.88 11.01 58 87053 24410 90516926
Myocardial bridging 17.85 11.01 3 87108 0 90541336
Dermatitis bullous 17.82 11.01 34 87077 10282 90531054
Agitation 17.80 11.01 118 86993 66980 90474356
Ventricular hypertrophy 17.76 11.01 19 87092 3372 90537964
Hepatic cytolysis 17.70 11.01 4 87107 30912 90510424
Stent placement 17.66 11.01 21 87090 4182 90537154
Dizziness 17.41 11.01 712 86399 588572 89952764
Upper gastrointestinal haemorrhage 17.28 11.01 55 87056 22921 90518415
Incorrect route of product administration 17.23 11.01 14 87097 50612 90490724
Angioedema 17.15 11.01 114 86997 64762 90476574
Duodenal ulcer 17.14 11.01 32 87079 9520 90531816
Nodal rhythm 16.88 11.01 14 87097 1804 90539532
Diarrhoea 16.81 11.01 735 86376 938455 89602881
Adverse reaction 16.70 11.01 4 87107 29708 90511628
Atrioventricular block second degree 16.69 11.01 21 87090 4431 90536905
Therapeutic product effect delayed 16.65 11.01 19 87092 3622 90537714
Paraesthesia 16.62 11.01 157 86954 250169 90291167
Pericardial haemorrhage 16.50 11.01 14 87097 1862 90539474
Catheterisation cardiac 16.43 11.01 22 87089 4934 90536402
Brain stem stroke 16.33 11.01 8 87103 410 90540926
Vision blurred 16.32 11.01 170 86941 110123 90431213
Periorbital haematoma 16.30 11.01 10 87101 801 90540535
Subcapsular splenic haematoma 16.18 11.01 4 87107 23 90541313
Cytomegalovirus infection 16.14 11.01 3 87108 26599 90514737
Ear pain 16.12 11.01 19 87092 57683 90483653
Ventricular fibrillation 15.88 11.01 39 87072 14005 90527331
Skin cancer 15.78 11.01 38 87073 13481 90527855
Throat tightness 15.68 11.01 63 87048 29421 90511915
Gastric haemorrhage 15.60 11.01 26 87085 7077 90534259
Ear infection 15.51 11.01 27 87084 69748 90471588
Coronary artery thrombosis 15.45 11.01 11 87100 1131 90540205
Hepatic cirrhosis 15.45 11.01 23 87088 63230 90478106
Neoplasm skin 15.40 11.01 17 87094 3125 90538211
No adverse event 15.39 11.01 26 87085 67956 90473380
Hypokalaemia 15.31 11.01 193 86918 130923 90410413
Non-cardiac chest pain 15.29 11.01 25 87086 6696 90534640
Blood creatine phosphokinase increased 15.23 11.01 69 87042 33954 90507382
Stent malfunction 15.21 11.01 5 87106 88 90541248
Blindness 15.12 11.01 58 87053 26510 90514826
Vulvovaginal mycotic infection 15.07 11.01 24 87087 6290 90535046
Discoloured vomit 15.03 11.01 11 87100 1181 90540155
Coronary artery dissection 14.81 11.01 10 87101 944 90540392
Arthritis 14.80 11.01 97 87014 167218 90374118
Arrhythmia 14.78 11.01 80 87031 42252 90499084
Systolic anterior motion of mitral valve 14.72 11.01 4 87107 35 90541301
Device issue 14.71 11.01 5 87106 29532 90511804
Multiple injuries 14.55 11.01 13 87098 1852 90539484
Abdominal wall haematoma 14.50 11.01 17 87094 3335 90538001
Bladder disorder 14.46 11.01 32 87079 10740 90530596
Morbid thoughts 14.40 11.01 9 87102 745 90540591
Blood triglycerides increased 14.29 11.01 37 87074 13724 90527612
Hypertensive heart disease 14.19 11.01 15 87096 2625 90538711
Peripheral ischaemia 14.16 11.01 22 87089 5645 90535691
Generalised tonic-clonic seizure 14.08 11.01 8 87103 34895 90506441
Diverticulum 14.08 11.01 34 87077 12079 90529257
Anosmia 14.07 11.01 30 87081 9818 90531518
Troponin T increased 14.04 11.01 12 87099 1611 90539725
Arteriogram coronary abnormal 13.96 11.01 3 87108 8 90541328
Essential hypertension 13.71 11.01 23 87088 6292 90535044
Cardioactive drug level increased 13.63 11.01 14 87097 2370 90538966
Pleural effusion 13.57 11.01 166 86945 111825 90429511
Micturition urgency 13.57 11.01 32 87079 11201 90530135
Bone marrow failure 13.56 11.01 7 87104 32214 90509122
Palmar-plantar erythrodysaesthesia syndrome 13.52 11.01 5 87106 28018 90513318
Cytokine release syndrome 13.48 11.01 5 87106 27968 90513368
Diplopia 13.43 11.01 59 87052 28655 90512681
Bundle branch block right 13.39 11.01 21 87090 5432 90535904
Vascular graft 13.38 11.01 9 87102 844 90540492
Anaemia macrocytic 13.21 11.01 19 87092 4553 90536783
Choking 13.17 11.01 33 87078 12000 90529336
Walking aid user 13.14 11.01 9 87102 35497 90505839
Neoplasm progression 13.13 11.01 14 87097 44472 90496864
Skin oedema 13.10 11.01 10 87101 1144 90540192
Drug eruption 13.07 11.01 9 87102 35398 90505938
Device dislocation 13.02 11.01 7 87104 31475 90509861
Atrioventricular block complete 13.01 11.01 29 87082 9782 90531554
Disability 12.97 11.01 12 87099 40733 90500603
Myocardial oedema 12.91 11.01 7 87104 444 90540892
Renal artery stenosis 12.84 11.01 13 87098 2164 90539172
Finger amputation 12.82 11.01 8 87103 660 90540676
Left ventricular failure 12.72 11.01 23 87088 6677 90534659
Limb injury 12.71 11.01 62 87049 31446 90509890
Bacteriuria 12.71 11.01 10 87101 1196 90540140
Dementia 12.70 11.01 51 87060 23810 90517526
Colitis ischaemic 12.62 11.01 33 87078 12313 90529023
Hiatus hernia 12.55 11.01 53 87058 25308 90516028
Heparin-induced thrombocytopenia 12.41 11.01 20 87091 5292 90536044
Blood chloride decreased 12.39 11.01 22 87089 6297 90535039
Pulmonary congestion 12.38 11.01 44 87067 19389 90521947
Blood urea increased 12.38 11.01 60 87051 30353 90510983
Therapy partial responder 12.33 11.01 3 87108 22040 90519296
Head injury 12.32 11.01 61 87050 31127 90510209
Lupus myocarditis 12.30 11.01 4 87107 68 90541268
Herpes zoster 12.29 11.01 48 87063 94596 90446740
Coagulation time abnormal 12.24 11.01 4 87107 69 90541267
Electrocardiogram T wave abnormal 12.24 11.01 14 87097 2674 90538662
Urinary tract infection 12.14 11.01 382 86729 305250 90236086
Leg amputation 12.07 11.01 13 87098 2324 90539012
Gastritis 12.04 11.01 75 87036 41678 90499658
Dilatation atrial 12.00 11.01 12 87099 1969 90539367
Coronary artery compression 11.89 11.01 3 87108 19 90541317
Hydrothorax 11.83 11.01 9 87102 1024 90540312
Flank pain 11.80 11.01 43 87068 19179 90522157
Patent ductus arteriosus 11.79 11.01 18 87093 4551 90536785
Electrocardiogram PR shortened 11.72 11.01 7 87104 534 90540802
Urogenital disorder 11.69 11.01 4 87107 80 90541256
Normal newborn 11.56 11.01 4 87107 23358 90517978
Electrocardiogram ST segment depression 11.47 11.01 15 87096 3288 90538048
Tuberculosis of central nervous system 11.40 11.01 6 87105 358 90540978
Normochromic anaemia 11.40 11.01 6 87105 358 90540978
Atrophy 11.35 11.01 12 87099 2100 90539236
Hyponatraemic syndrome 11.34 11.01 7 87104 567 90540769
Coronary angioplasty 11.34 11.01 4 87107 88 90541248
Blood osmolarity increased 11.31 11.01 6 87105 364 90540972
Arterial insufficiency 11.12 11.01 5 87106 211 90541125
Femur fracture 11.02 11.01 17 87094 46065 90495271
Carotid artery stenosis 11.02 11.01 19 87092 5315 90536021

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 1012.93 11.14 1181 75762 122828 42421564
Coronary artery disease 509.78 11.14 554 76389 53166 42491226
Acute myocardial infarction 447.25 11.14 538 76405 57627 42486765
Angina pectoris 430.77 11.14 404 76539 32492 42511900
Cardiac failure congestive 419.85 11.14 636 76307 84966 42459426
Chest pain 403.05 11.14 821 76122 138709 42405683
Angina unstable 247.94 11.14 188 76755 11260 42533132
Injury 239.65 11.14 246 76697 22070 42522322
Fear 215.51 11.14 170 76773 10795 42533597
Coronary arterial stent insertion 199.99 11.14 111 76832 3874 42540518
Anhedonia 198.35 11.14 140 76803 7500 42536892
Off label use 168.80 11.14 591 76352 637744 41906648
Emotional distress 164.85 11.14 173 76770 15920 42528472
Renal injury 157.16 11.14 149 76794 12131 42532261
Hypotension 151.91 11.14 887 76056 256744 42287648
Drug abuse 141.53 11.14 13 76930 104758 42439634
Bradycardia 117.08 11.14 380 76563 85104 42459288
Myocardial ischaemia 108.98 11.14 147 76796 17615 42526777
Syncope 105.26 11.14 406 76537 99000 42445392
Product solubility abnormal 105.19 11.14 40 76903 564 42543828
Troponin increased 100.94 11.14 147 76796 18915 42525477
Neutropenia 100.01 11.14 128 76815 199303 42345089
Dizziness 94.29 11.14 770 76173 248484 42295908
Unevaluable event 94.25 11.14 198 76745 34090 42510302
Cardiac disorder 90.38 11.14 242 76701 48690 42495702
Chronic obstructive pulmonary disease 87.69 11.14 282 76661 62832 42481560
Ischaemic cardiomyopathy 87.02 11.14 81 76862 6441 42537951
Febrile neutropenia 82.37 11.14 130 76813 185573 42358819
Toxicity to various agents 80.94 11.14 184 76759 228952 42315440
Reversible airways obstruction 80.68 11.14 33 76910 570 42543822
Coronary artery bypass 80.66 11.14 68 76875 4742 42539650
Stress 74.05 11.14 211 76732 44001 42500391
Coronary artery occlusion 72.06 11.14 94 76849 10903 42533489
Dyspnoea 68.20 11.14 1149 75794 441472 42102920
Cerebrovascular accident 67.40 11.14 350 76593 96810 42447582
Acute coronary syndrome 66.49 11.14 106 76837 14759 42529633
Malignant neoplasm progression 64.88 11.14 60 76883 108340 42436052
Atrial fibrillation 63.76 11.14 451 76492 139142 42405250
Presyncope 61.19 11.14 129 76814 22258 42522134
Foetal exposure during pregnancy 60.94 11.14 7 76936 47304 42497088
Brain scan abnormal 60.77 11.14 34 76909 1205 42543187
Cerebral artery thrombosis 60.51 11.14 34 76909 1215 42543177
Anxiety 59.45 11.14 392 76551 118168 42426224
Hyperlipidaemia 56.52 11.14 122 76821 21394 42522998
Soft tissue mass 55.79 11.14 30 76913 982 42543410
Drug ineffective 55.66 11.14 803 76140 629394 41914998
Disease progression 55.14 11.14 110 76833 143546 42400846
Chest discomfort 52.58 11.14 241 76702 63375 42481017
Multimorbidity 52.28 11.14 28 76915 909 42543483
Cytokine release syndrome 51.71 11.14 9 76934 44518 42499874
Coronary artery stenosis 50.58 11.14 77 76866 10302 42534090
Therapeutic product effect incomplete 50.37 11.14 33 76910 70906 42473486
Ventricular extrasystoles 48.62 11.14 87 76856 13303 42531089
Ventricular tachycardia 47.66 11.14 141 76802 30019 42514373
Cardiac failure 47.46 11.14 343 76600 106513 42437879
Pyrexia 46.12 11.14 472 76471 393570 42150822
Oesophageal perforation 45.13 11.14 28 76915 1205 42543187
Treatment failure 44.64 11.14 29 76914 62595 42481797
C-reactive protein increased 44.55 11.14 30 76913 63530 42480862
Mucosal inflammation 44 11.14 17 76926 49357 42495035
Renal failure 43.38 11.14 423 76520 143303 42401089
Middle insomnia 42.33 11.14 61 76882 7772 42536620
Gastrointestinal haemorrhage 41.85 11.14 311 76632 97415 42446977
Drug reaction with eosinophilia and systemic symptoms 41.84 11.14 12 76931 42063 42502329
Pain 41.03 11.14 645 76298 244203 42300189
Leukopenia 40.57 11.14 45 76898 74701 42469691
COVID-19 40.15 11.14 94 76849 115854 42428538
Ventricular dysfunction 40.14 11.14 45 76898 4458 42539934
Product use in unapproved indication 38.23 11.14 187 76756 184269 42360123
Cardiomegaly 37.28 11.14 89 76854 16677 42527715
Cytomegalovirus infection 36.50 11.14 7 76936 32299 42512093
Ventricular fibrillation 35.99 11.14 128 76815 29995 42514397
International normalised ratio increased 35.81 11.14 177 76766 47991 42496401
Neutrophil count decreased 35.73 11.14 37 76906 63378 42481014
Bronchopulmonary aspergillosis allergic 34.40 11.14 42 76901 4556 42539836
Hypoglycaemia 33.12 11.14 203 76740 59651 42484741
Renal impairment 33.04 11.14 324 76619 109904 42434488
Hepatic function abnormal 32.70 11.14 27 76916 51540 42492852
Areflexia 32.68 11.14 37 76906 3706 42540686
Arteriospasm coronary 31.82 11.14 41 76902 4697 42539695
Rales 31.51 11.14 66 76877 11334 42533058
Pulmonary oedema 30.31 11.14 182 76761 53090 42491302
White blood cell count decreased 29.71 11.14 101 76842 110295 42434097
Intentional product use issue 29.29 11.14 53 76890 71780 42472612
Orthostatic hypotension 29.21 11.14 121 76822 30449 42513943
Labelled drug-drug interaction medication error 28.68 11.14 77 76866 15505 42528887
Infection 28.51 11.14 105 76838 111963 42432429
Bronchial irritation 27.51 11.14 8 76935 45 42544347
Superinfection 27.18 11.14 30 76913 2921 42541471
Neurotoxicity 26.98 11.14 5 76938 23646 42520746
Completed suicide 26.82 11.14 87 76856 96378 42448014
Peripheral vascular disorder 26.70 11.14 40 76903 5277 42539115
Prinzmetal angina 26.57 11.14 21 76922 1336 42543056
Stomatitis 26.55 11.14 31 76912 50298 42494094
Base excess decreased 26.43 11.14 11 76932 199 42544193
Arteriosclerosis coronary artery 26.41 11.14 84 76859 18593 42525799
Rash 26.39 11.14 347 76596 276607 42267785
Electrocardiogram ST segment elevation 26.08 11.14 42 76901 5897 42538495
Diarrhoea 25.94 11.14 634 76309 460215 42084177
Hemiplegia 25.84 11.14 49 76894 7830 42536562
Neuroleptic malignant syndrome 25.69 11.14 4 76939 21468 42522924
Therapy partial responder 25.68 11.14 3 76940 20018 42524374
Cardiac arrest 25.64 11.14 306 76637 109014 42435378
Anticoagulant therapy 25.51 11.14 36 76907 4499 42539893
Gout 25.21 11.14 109 76834 27946 42516446
Hypercholesterolaemia 25.18 11.14 65 76878 12784 42531608
Congenital hiatus hernia 24.87 11.14 42 76901 6132 42538260
Infusion related reaction 24.67 11.14 45 76898 60761 42483631
Rhabdomyolysis 24.19 11.14 231 76712 77788 42466604
Post procedural complication 23.97 11.14 63 76880 12527 42531865
Platelet count decreased 23.51 11.14 150 76793 138431 42405961
Fall 23.02 11.14 570 76373 233950 42310442
Antacid therapy 22.99 11.14 35 76908 4682 42539710
Ischaemic stroke 22.83 11.14 90 76853 22143 42522249
Cardiovascular disorder 22.57 11.14 64 76879 13301 42531091
Coronary artery thrombosis 22.38 11.14 24 76919 2262 42542130
Injection site pain 22.37 11.14 44 76899 57754 42486638
Myelosuppression 22.35 11.14 24 76919 40437 42503955
Vascular graft 22.07 11.14 20 76923 1536 42542856
Pleuritic pain 21.97 11.14 43 76900 7034 42537358
Myalgia 21.68 11.14 267 76676 95813 42448579
Full blood count abnormal 21.64 11.14 109 76834 29767 42514625
Device dislocation 21.25 11.14 45 76898 7786 42536606
Blood loss anaemia 20.91 11.14 51 76892 9685 42534707
Orthopnoea 20.70 11.14 36 76907 5381 42539011
Analgesic therapy 20.69 11.14 40 76903 6484 42537908
Alanine aminotransferase increased 20.46 11.14 86 76857 88320 42456072
Sleep disorder therapy 20.33 11.14 41 76902 6853 42537539
Pneumocystis jirovecii pneumonia 20.33 11.14 10 76933 25171 42519221
Nerve degeneration 20.09 11.14 9 76934 196 42544196
Blood calcium increased 20.02 11.14 46 76897 8408 42535984
Hypomagnesaemia 19.98 11.14 103 76840 28385 42516007
Neoplasm progression 19.90 11.14 14 76929 28986 42515406
Transplant failure 19.70 11.14 30 76913 4014 42540378
Myasthenia gravis 19.64 11.14 69 76874 16068 42528324
International normalised ratio decreased 19.62 11.14 32 76911 4540 42539852
Sinus bradycardia 19.38 11.14 65 76878 14788 42529604
Haemoptysis 19.22 11.14 146 76797 46021 42498371
Ureteric injury 18.93 11.14 6 76937 47 42544345
Vascular stent occlusion 18.84 11.14 9 76934 228 42544164
Reperfusion arrhythmia 18.58 11.14 7 76936 96 42544296
Gastrooesophageal reflux disease 18.53 11.14 142 76801 44881 42499511
Bronchopulmonary aspergillosis 18.49 11.14 6 76937 19423 42524969
Neuropathy peripheral 18.44 11.14 108 76835 101745 42442647
Septic shock 18.36 11.14 94 76849 91578 42452814
Laryngeal haematoma 18.35 11.14 8 76935 163 42544229
Melaena 18.12 11.14 126 76817 38620 42505772
Hyperthyroidism 18.04 11.14 62 76881 14279 42530113
Dizziness postural 18.00 11.14 42 76901 7753 42536639
Device malfunction 17.94 11.14 56 76887 12271 42532121
Inappropriate schedule of product administration 17.73 11.14 101 76842 95801 42448591
Loss of personal independence in daily activities 17.54 11.14 40 76903 49776 42494616
Overdose 17.31 11.14 115 76828 105149 42439243
Stent placement 17.17 11.14 33 76910 5327 42539065
Hepatic cytolysis 17.09 11.14 14 76929 26830 42517562
Palmar-plantar erythrodysaesthesia syndrome 16.88 11.14 8 76935 20574 42523818
Oral mucosal eruption 16.84 11.14 10 76933 397 42543995
Renin increased 16.78 11.14 8 76935 202 42544190
Acute kidney injury 16.76 11.14 817 76126 366520 42177872
Folate deficiency 16.58 11.14 18 76925 1721 42542671
Drug therapy 16.55 11.14 36 76907 6344 42538048
Transient ischaemic attack 16.54 11.14 111 76832 33628 42510764
Oxygen consumption decreased 16.53 11.14 9 76934 302 42544090
Myocardial bridging 16.51 11.14 5 76938 33 42544359
Tendon disorder 16.31 11.14 25 76918 3364 42541028
Circulatory collapse 16.26 11.14 85 76858 23551 42520841
Colitis ulcerative 16.23 11.14 14 76929 26161 42518231
Acute pulmonary oedema 16.17 11.14 43 76900 8608 42535784
Cardiac arrest neonatal 16.14 11.14 5 76938 36 42544356
Post procedural haemorrhage 16.13 11.14 45 76898 9267 42535125
Drug resistance 16.09 11.14 23 76920 34225 42510167
Cold sweat 16.06 11.14 51 76892 11279 42533113
Ecchymosis 16.01 11.14 40 76903 7712 42536680
Non-cardiac chest pain 15.90 11.14 29 76914 4500 42539892
Coma 15.80 11.14 47 76896 53507 42490885
Intentional self-injury 15.74 11.14 4 76939 15198 42529194
Extrapyramidal disorder 15.74 11.14 5 76938 16407 42527985
Vascular stent thrombosis 15.72 11.14 24 76919 3218 42541174
No adverse event 15.72 11.14 29 76914 38992 42505400
Vascular graft occlusion 15.67 11.14 11 76932 584 42543808
Condition aggravated 15.65 11.14 355 76588 260399 42283993
Thrombocytopenia 15.44 11.14 246 76697 190033 42354359
Pancytopenia 15.42 11.14 137 76806 117606 42426786
Coronary artery restenosis 15.39 11.14 13 76930 909 42543483
Vasculitis 15.31 11.14 7 76936 18387 42526005
Loss of consciousness 15.31 11.14 243 76700 92111 42452281
Multiple injuries 15.26 11.14 18 76925 1884 42542508
Transplant rejection 15.23 11.14 3 76940 13585 42530807
Inflammatory marker increased 15.17 11.14 36 76907 6720 42537672
Cervicogenic headache 15.07 11.14 4 76939 15 42544377
Haemophagocytic lymphohistiocytosis 15.07 11.14 7 76936 18215 42526177
Hepatotoxicity 14.96 11.14 14 76929 25153 42519239
Blood pressure decreased 14.88 11.14 166 76777 58166 42486226
Asthma 14.85 11.14 175 76768 62139 42482253
Haematoma 14.84 11.14 94 76849 27929 42516463
Cardiac procedure complication 14.74 11.14 7 76936 175 42544217
Asthenia 14.63 11.14 633 76310 280160 42264232
Seizure 14.62 11.14 143 76800 120418 42423974
Intentional overdose 14.58 11.14 46 76897 51410 42492982
Activated partial thromboplastin time prolonged 14.45 11.14 62 76881 15841 42528551
Supraventricular tachycardia 14.20 11.14 52 76891 12356 42532036
Tubulointerstitial nephritis 14.04 11.14 22 76921 31526 42512866
Oedema peripheral 14.01 11.14 333 76610 135743 42408649
Viral infection 13.97 11.14 12 76931 22471 42521921
Bone marrow failure 13.86 11.14 24 76919 33069 42511323
Arterial occlusive disease 13.75 11.14 27 76916 4426 42539966
Acute myeloid leukaemia 13.68 11.14 12 76931 22244 42522148
Tumour lysis syndrome 13.65 11.14 12 76931 22219 42522173
Subacute cutaneous lupus erythematosus 13.49 11.14 15 76928 1473 42542919
Sinus node dysfunction 13.46 11.14 28 76915 4784 42539608
Drug hypersensitivity 13.40 11.14 253 76690 99136 42445256
Product dose omission issue 13.39 11.14 197 76746 154168 42390224
Hypercalcaemia 13.37 11.14 8 76935 18050 42526342
Carotid artery stenosis 13.34 11.14 30 76913 5406 42538986
Arrhythmia 13.30 11.14 121 76822 40196 42504196
Atrial flutter 13.25 11.14 64 76879 17187 42527205
Gastrointestinal tract irritation 13.13 11.14 8 76935 333 42544059
Pruritus 13.08 11.14 251 76692 188520 42355872
Coronary bypass thrombosis 13.02 11.14 3 76940 5 42544387
Anaphylactoid reaction 12.97 11.14 21 76922 2962 42541430
Sedation 12.86 11.14 22 76921 30453 42513939
Hyperbilirubinaemia 12.84 11.14 11 76932 20624 42523768
Diabetes mellitus 12.70 11.14 165 76778 59922 42484470
Mitral valve incompetence 12.54 11.14 61 76882 16428 42527964
Alopecia 12.48 11.14 21 76922 29255 42515137
Breath sounds abnormal 12.45 11.14 49 76894 12044 42532348
Lymphadenopathy 12.40 11.14 26 76917 33339 42511053
Ureteral disorder 12.39 11.14 6 76937 157 42544235
Acetonaemia 12.36 11.14 7 76936 254 42544138
Disseminated intravascular coagulation 12.31 11.14 16 76927 24778 42519614
Herpes zoster 12.29 11.14 33 76910 38844 42505548
Lower respiratory tract infection 12.27 11.14 121 76822 41085 42503307
Colitis 12.25 11.14 43 76900 46529 42497863
Coagulation time prolonged 12.24 11.14 14 76929 1418 42542974
Myocardial necrosis marker increased 12.19 11.14 16 76927 1866 42542526
Blood creatine phosphokinase increased 12.07 11.14 137 76806 48201 42496191
Acute hepatic failure 12.04 11.14 8 76935 17065 42527327
Contusion 11.88 11.14 122 76821 41863 42502529
Carotid artery disease 11.85 11.14 11 76932 871 42543521
Chronic kidney disease 11.85 11.14 134 76809 47107 42497285
Essential hypertension 11.82 11.14 23 76920 3745 42540647
Coronary steal syndrome 11.81 11.14 3 76940 9 42544383
Osteoarthritis 11.79 11.14 80 76863 24325 42520067
Osteonecrosis 11.78 11.14 7 76936 15858 42528534
Organ failure 11.74 11.14 18 76925 2422 42541970
Thrombotic microangiopathy 11.73 11.14 6 76937 14776 42529616
Hiatus hernia 11.65 11.14 38 76905 8522 42535870
Poisoning 11.62 11.14 6 76937 14693 42529699
Aplastic anaemia 11.48 11.14 4 76939 12380 42532012
Ventricular asystole 11.46 11.14 7 76936 293 42544099
Hallucination, visual 11.44 11.14 71 76872 20949 42523443
Myeloperoxidase deficiency 11.42 11.14 4 76939 44 42544348
Wheezing 11.40 11.14 150 76793 54631 42489761
Angiogram 11.37 11.14 6 76937 189 42544203
Confusional state 11.37 11.14 389 76554 167208 42377184
Coronary no-reflow phenomenon 11.36 11.14 3 76940 11 42544381
Vasospasm 11.33 11.14 9 76934 577 42543815
Interstitial lung disease 11.31 11.14 89 76854 78373 42466019
Lung consolidation 11.30 11.14 32 76911 6645 42537747
Depression 11.30 11.14 272 76671 111091 42433301
Atrioventricular block second degree 11.29 11.14 24 76919 4163 42540229
Coronary ostial stenosis 11.24 11.14 5 76938 107 42544285
Arteriosclerosis 11.23 11.14 63 76880 17926 42526466
Extrasystoles 11.20 11.14 24 76919 4185 42540207
Erythema 11.20 11.14 134 76809 108659 42435733

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 2082.41 10.88 1834 141842 190249 110255374
Coronary artery disease 1015.30 10.88 800 142876 70890 110374733
Cardiac failure congestive 893.34 10.88 1040 142636 149960 110295663
Acute myocardial infarction 870.49 10.88 782 142894 82995 110362628
Orthostatic hypotension 741.25 10.88 645 143031 65604 110380019
Angina pectoris 701.99 10.88 609 143067 61686 110383937
Creatinine renal clearance decreased 700.95 10.88 405 143271 21410 110424213
Sedation complication 655.00 10.88 375 143301 19480 110426143
Hypotension 563.72 10.88 1725 141951 522124 109923499
Blood calcium decreased 533.23 10.88 412 143264 35433 110410190
Chest pain 469.32 10.88 1307 142369 375068 110070555
Angina unstable 431.61 10.88 268 143408 16164 110429459
Balance disorder 416.07 10.88 627 143049 115933 110329690
Cognitive disorder 398.63 10.88 529 143147 86982 110358641
Sedation 372.26 10.88 456 143220 69227 110376396
Coronary arterial stent insertion 358.01 10.88 168 143508 5747 110439876
Fear 317.77 10.88 254 143422 22939 110422684
Fall 316.23 10.88 1584 142092 601898 109843725
Renal injury 289.03 10.88 220 143456 18493 110427130
Depressed level of consciousness 288.61 10.88 521 143155 111757 110333866
Anhedonia 268.79 10.88 195 143481 15233 110430390
Constipation 261.89 10.88 1038 142638 356748 110088875
Hand deformity 258.96 10.88 5 143671 218501 110227122
Systemic lupus erythematosus 246.47 10.88 23 143653 254315 110191308
Bradycardia 225.77 10.88 572 143104 154945 110290678
Glossodynia 223.55 10.88 17 143659 221987 110223636
Emotional distress 221.13 10.88 282 143394 44565 110401058
Treatment failure 219.86 10.88 46 143630 277188 110168435
Myocardial ischaemia 215.78 10.88 217 143459 26467 110419156
Hepatic enzyme increased 208.56 10.88 78 143598 320814 110124809
Helicobacter infection 208.44 10.88 6 143670 181871 110263752
Synovitis 208.26 10.88 50 143626 274042 110171581
Duodenal ulcer perforation 206.88 10.88 5 143671 177695 110267928
Renal failure 206.57 10.88 706 142970 225868 110219755
Off label use 203.76 10.88 1133 142543 1499052 108946571
Alopecia 203.69 10.88 110 143566 364643 110080980
Maternal exposure during pregnancy 190.72 10.88 48 143628 254835 110190788
Acute coronary syndrome 183.31 10.88 186 143490 22926 110422697
Unevaluable event 181.25 10.88 297 143379 58930 110386693
Cerebrovascular accident 177.74 10.88 579 143097 180705 110264918
Arthropathy 176.84 10.88 76 143600 287446 110158177
Syncope 170.68 10.88 615 143061 201921 110243702
Gastrointestinal haemorrhage 169.85 10.88 537 143139 164981 110280642
Troponin increased 165.76 10.88 199 143477 29567 110416056
Bronchopulmonary aspergillosis allergic 164.10 10.88 114 143562 8312 110437311
Coronary artery occlusion 163.20 10.88 147 143529 15625 110429998
Macular degeneration 158.61 10.88 167 143509 21492 110424131
Contraindicated product administered 158.54 10.88 62 143614 248205 110197418
Ischaemic cardiomyopathy 157.46 10.88 109 143567 7902 110437721
Psoriatic arthropathy 157.31 10.88 32 143644 196729 110248894
Rales 157.18 10.88 177 143499 24562 110421061
Rheumatoid factor positive 155.99 10.88 3 143673 131637 110313986
Dyspnoea 151.69 10.88 2143 141533 1104729 109340894
Pericarditis 151.42 10.88 48 143628 219066 110226557
Atrial fibrillation 151.06 10.88 645 143031 228997 110216626
Vaginal flatulence 149.54 10.88 125 143551 12019 110433604
Chronic obstructive pulmonary disease 146.56 10.88 390 143286 108768 110336855
Impaired healing 141.55 10.88 40 143636 196677 110248946
Rheumatic fever 140.60 10.88 4 143672 122575 110323048
Chronic sinusitis 140.17 10.88 168 143508 24916 110420707
Paraesthesia oral 138.78 10.88 194 143482 33477 110412146
Rheumatoid arthritis 136.76 10.88 113 143563 299500 110146123
Radiculopathy 136.12 10.88 146 143530 19190 110426433
Muscle injury 135.66 10.88 13 143663 140794 110304829
Coronary artery bypass 134.98 10.88 89 143587 5953 110439670
Irritable bowel syndrome 134.87 10.88 25 143651 164190 110281433
Joint swelling 133.96 10.88 231 143445 442614 110003009
Cardiac disorder 133.76 10.88 302 143374 75978 110369645
Drug intolerance 131.41 10.88 203 143473 406309 110039314
Infection 130.88 10.88 167 143509 362033 110083590
Therapeutic product effect decreased 130.14 10.88 78 143598 244238 110201385
Female genital tract fistula 129.29 10.88 132 143544 16387 110429236
Proctitis 126.60 10.88 132 143544 16795 110428828
Neutropenia 126.00 10.88 182 143494 374438 110071185
Hypersensitivity 123.77 10.88 209 143467 403789 110041834
Intentional product use issue 122.71 10.88 86 143590 247820 110197803
Cardiac failure 121.82 10.88 525 143151 187101 110258522
Discomfort 120.89 10.88 64 143612 214643 110230980
Vaginal discharge 118.70 10.88 131 143545 17777 110427846
Stomatitis 117.16 10.88 107 143569 270135 110175488
Renal impairment 116.80 10.88 520 143156 187925 110257698
Blood calcium increased 116.19 10.88 130 143546 17910 110427713
Abdominal discomfort 114.98 10.88 210 143466 393648 110051975
Stress 114.71 10.88 349 143327 104999 110340624
Febrile neutropenia 114.49 10.88 146 143530 316621 110129002
C-reactive protein increased 114.07 10.88 71 143605 217848 110227775
Facet joint syndrome 111.64 10.88 3 143673 96825 110348798
Transient ischaemic attack 110.71 10.88 252 143424 63730 110381893
Hyperkalaemia 110.67 10.88 408 143268 135388 110310235
Wound 107.48 10.88 88 143588 234349 110211274
Haemoptysis 106.15 10.88 265 143411 71089 110374534
Arteriospasm coronary 104.53 10.88 90 143586 9010 110436613
Total lung capacity decreased 104.08 10.88 81 143595 7033 110438590
Nasopharyngitis 103.31 10.88 224 143452 394137 110051486
Coronary artery stenosis 102.38 10.88 107 143569 13651 110431972
Acute kidney injury 101.54 10.88 1266 142410 634164 109811459
Ill-defined disorder 100.39 10.88 39 143637 156814 110288809
Product use issue 99.40 10.88 157 143519 311538 110134085
Drug interaction 98.97 10.88 1039 142637 499144 109946479
Ventricular tachycardia 97.91 10.88 207 143469 49802 110395821
Anaemia 94.79 10.88 1107 142569 545979 109899644
Exposure during pregnancy 92.64 10.88 51 143625 167373 110278250
Bursitis 92.37 10.88 27 143649 129891 110315732
Hyperlipidaemia 91.60 10.88 166 143510 35682 110409941
Infusion related reaction 89.83 10.88 229 143447 380933 110064690
Sputum discoloured 89.38 10.88 143 143533 27802 110417821
Presyncope 88.44 10.88 196 143480 48691 110396932
Labile blood pressure 87.77 10.88 49 143627 2422 110443201
Rectal haemorrhage 87.73 10.88 348 143328 119485 110326138
Rash 87.04 10.88 667 143009 820297 109625326
Cardiac arrest 85.32 10.88 491 143185 196262 110249361
Arthralgia 84.73 10.88 629 143047 779003 109666620
Cardiomegaly 83.65 10.88 142 143534 28988 110416635
Joint range of motion decreased 83.59 10.88 27 143649 121805 110323818
Peripheral vascular disorder 81.08 10.88 76 143600 8500 110437123
Chest discomfort 80.78 10.88 442 143234 173406 110272217
Procedural pain 80.06 10.88 156 143520 35409 110410214
Condition aggravated 79.77 10.88 593 143083 734243 109711380
Lung opacity 78.55 10.88 86 143590 11566 110434057
Inflammation 78.53 10.88 81 143595 193157 110252466
Sinusitis 78.10 10.88 168 143508 296520 110149103
International normalised ratio increased 77.77 10.88 269 143407 86503 110359120
Creatinine renal clearance increased 77.60 10.88 52 143624 3573 110442050
Swelling 76.61 10.88 219 143457 350822 110094801
Pulmonary oedema 75.85 10.88 295 143381 100364 110345259
Dizziness 75.84 10.88 1301 142375 696892 109748731
Liver injury 74.64 10.88 52 143624 150361 110295262
Aspiration 72.50 10.88 137 143539 30396 110415227
Hypoglycaemia 72.37 10.88 321 143355 115783 110329840
Malignant neoplasm progression 72.27 10.88 72 143604 174495 110271128
Blister 72.03 10.88 115 143561 227261 110218362
Live birth 70.83 10.88 5 143671 69479 110376144
Grip strength decreased 70.76 10.88 10 143666 80164 110365459
Pain 70.32 10.88 1679 141997 953276 109492347
Myelosuppression 70.07 10.88 18 143658 94322 110351301
Prinzmetal angina 69.89 10.88 41 143635 2228 110443395
Brain scan abnormal 69.37 10.88 36 143640 1535 110444088
Peripheral venous disease 68.64 10.88 13 143663 84104 110361519
Weight increased 68.01 10.88 297 143379 419347 110026276
Type 2 diabetes mellitus 65.76 10.88 80 143596 177152 110268471
Epilepsy 65.65 10.88 24 143652 100185 110345438
Rhabdomyolysis 65.56 10.88 320 143356 120081 110325542
Disease progression 65.21 10.88 137 143539 243897 110201726
Arteriosclerosis coronary artery 65.05 10.88 117 143559 25001 110420622
Pleuritic pain 63.56 10.88 91 143585 16049 110429574
Autoimmune disorder 63.19 10.88 6 143670 65477 110380146
Ventricular fibrillation 62.03 10.88 154 143522 41159 110404464
Obstructive airways disorder 62.03 10.88 165 143511 45984 110399639
Product solubility abnormal 61.19 10.88 30 143646 1132 110444491
Lower limb fracture 60.73 10.88 12 143664 75336 110370287
Blood creatinine increased 59.86 10.88 425 143251 182464 110263159
Product use in unapproved indication 59.66 10.88 339 143337 447038 109998585
Night sweats 59.29 10.88 52 143624 133931 110311692
Cerebral artery thrombosis 59.03 10.88 33 143643 1635 110443988
Blepharospasm 58.78 10.88 3 143673 54848 110390775
Injury 58.64 10.88 413 143263 176852 110268771
Wound infection 58.47 10.88 26 143650 96439 110349184
Injection site pain 58.24 10.88 88 143588 177834 110267789
Drug abuse 57.83 10.88 88 143588 177323 110268300
Multiple drug therapy 57.27 10.88 61 143615 7953 110437670
Cytokine release syndrome 57.08 10.88 11 143665 70295 110375328
Blood test abnormal 56.83 10.88 119 143557 28435 110417188
Mucosal inflammation 56.58 10.88 27 143649 96114 110349509
Drug ineffective 56.50 10.88 1525 142151 1519015 108926608
Fibromyalgia 56.46 10.88 84 143592 170825 110274798
Heart sounds 55.72 10.88 28 143648 1115 110444508
Red blood cell sedimentation rate increased 54.34 10.88 17 143659 78285 110367338
Leukopenia 54.32 10.88 68 143608 148723 110296900
Sciatica 54.30 10.88 26 143650 92373 110353250
Oral candidiasis 54.16 10.88 154 143522 44606 110401017
Nail disorder 54.11 10.88 6 143670 57929 110387694
Pregnancy 54.07 10.88 3 143673 51064 110394559
Injection site reaction 53.99 10.88 24 143652 89046 110356577
Prolonged expiration 53.02 10.88 30 143646 1522 110444101
White blood cell count decreased 52.34 10.88 140 143536 229250 110216373
Anxiety 51.79 10.88 680 142996 344398 110101225
Renal function test abnormal 51.77 10.88 61 143615 8885 110436738
Gastrointestinal disorder 51.27 10.88 153 143523 241799 110203824
Multimorbidity 50.90 10.88 29 143647 1491 110444132
Soft tissue mass 50.67 10.88 29 143647 1504 110444119
Melaena 50.57 10.88 200 143476 68557 110377066
Ventricular extrasystoles 49.37 10.88 98 143578 22543 110423080
Hip arthroplasty 49.16 10.88 7 143669 55806 110389817
Blood cholesterol increased 49.13 10.88 104 143572 184681 110260942
Reversible airways obstruction 49.11 10.88 34 143642 2465 110443158
Neutrophil count decreased 48.78 10.88 51 143625 120890 110324733
Mitral valve incompetence 48.74 10.88 123 143553 33206 110412417
Hyponatraemia 48.18 10.88 463 143213 217190 110228433
Hypoaesthesia 48.12 10.88 227 143449 313996 110131627
Urticaria 47.87 10.88 232 143444 318625 110126998
Oesophageal pain 47.65 10.88 45 143631 5080 110440543
Angioplasty 46.39 10.88 30 143646 1941 110443682
Sinus node dysfunction 46.35 10.88 58 143618 8989 110436634
Haemorrhage 46.05 10.88 266 143410 106426 110339197
Oesophageal perforation 45.96 10.88 28 143648 1631 110443992
Taste disorder 45.73 10.88 14 143662 65373 110380250
Blood loss anaemia 45.45 10.88 83 143593 17942 110427681
Cytomegalovirus infection 45.31 10.88 8 143668 54436 110391187
Onychomadesis 44.55 10.88 4 143672 45659 110399964
Gait inability 44.10 10.88 68 143608 136308 110309315
Post procedural haemorrhage 43.72 10.88 75 143601 15437 110430186
Sinus bradycardia 43.31 10.88 109 143567 29374 110416249
Diarrhoea 43.21 10.88 1139 142537 1138366 109307257
Ventricular dysfunction 43.10 10.88 51 143625 7460 110438163
Intentional overdose 42.91 10.88 66 143610 132435 110313188
Prescribed overdose 42.50 10.88 31 143645 87550 110358073
Hepatic ischaemia 42.24 10.88 24 143652 1227 110444396
Haematoma 41.33 10.88 168 143508 58308 110387315
Lip swelling 41.06 10.88 152 143524 50515 110395108
Oedema peripheral 40.25 10.88 625 143051 328035 110117588
Obesity 40.13 10.88 53 143623 113298 110332325
Musculoskeletal pain 40.03 10.88 114 143562 182909 110262714
Mobility decreased 39.94 10.88 478 143198 236944 110208679
Sleep disorder 38.99 10.88 130 143546 198514 110247109
Hallucination 38.76 10.88 245 143431 101187 110344436
Drug reaction with eosinophilia and systemic symptoms 38.63 10.88 30 143646 82065 110363558
Labelled drug-drug interaction medication error 38.60 10.88 104 143572 29198 110416425
Knee arthroplasty 38.59 10.88 18 143658 64930 110380693
Laryngitis 38.11 10.88 5 143671 42406 110403217
Neurotoxicity 37.87 10.88 5 143671 42202 110403421
Injection site erythema 37.66 10.88 40 143636 94136 110351487
Areflexia 37.26 10.88 45 143631 6724 110438899
Coronary artery thrombosis 37.09 10.88 32 143644 3212 110442411
Congenital hiatus hernia 36.75 10.88 43 143633 6216 110439407
Electrocardiogram ST segment elevation 36.59 10.88 52 143624 9108 110436515
Dyspnoea exertional 36.50 10.88 246 143430 103814 110341809
Pruritus 36.40 10.88 534 143142 581026 109864597
Acute pulmonary oedema 36.38 10.88 73 143603 16923 110428700
Haematochezia 36.36 10.88 266 143410 115258 110330365
Chronic kidney disease 36.11 10.88 195 143481 76096 110369527
Muscle relaxant therapy 36.03 10.88 12 143664 160 110445463
Inappropriate schedule of product administration 35.52 10.88 140 143536 203497 110242126
Pulmonary mass 35.49 10.88 118 143558 37183 110408440
Coronary artery restenosis 35.30 10.88 21 143655 1171 110444452
Malaise 35.13 10.88 1131 142545 670688 109774935
Gout 35.08 10.88 116 143560 36450 110409173
Vascular graft 35.07 10.88 26 143650 2099 110443524
Circulatory collapse 34.85 10.88 129 143547 42864 110402759
Coeliac disease 34.55 10.88 7 143669 43180 110402443
Ischaemic stroke 34.45 10.88 125 143551 41138 110404485
Peripheral swelling 34.40 10.88 347 143329 403687 110041936
Myocardial bridging 34.37 10.88 8 143668 23 110445600
Bronchiectasis 34.33 10.88 115 143561 36378 110409245
Sleep apnoea syndrome 34.17 10.88 123 143553 40324 110405299
Lung disorder 33.86 10.88 120 143556 179927 110265696
Road traffic accident 33.35 10.88 55 143621 107343 110338280
Upper gastrointestinal haemorrhage 33.11 10.88 141 143535 49955 110395668
Arteriosclerosis 32.72 10.88 88 143588 24679 110420944
Therapeutic response decreased 32.28 10.88 47 143629 96452 110349171
Vascular stent thrombosis 32.11 10.88 33 143643 4128 110441495
Haematemesis 32.09 10.88 157 143519 58951 110386672
COVID-19 31.93 10.88 187 143489 244873 110200750
Anticoagulant therapy 31.76 10.88 37 143639 5324 110440299
Prescribed underdose 31.71 10.88 23 143653 65151 110380472
Hepatic cytolysis 31.58 10.88 16 143660 55037 110390586
Left ventricle outflow tract obstruction 31.56 10.88 15 143661 528 110445095
Neoplasm progression 31.16 10.88 23 143653 64572 110381051
Ischaemia 31.15 10.88 48 143628 9035 110436588
Blood pressure decreased 30.68 10.88 255 143421 114836 110330787
Percutaneous coronary intervention 30.55 10.88 14 143662 453 110445170
General physical health deterioration 30.39 10.88 380 143296 424915 110020708
Multiple injuries 30.34 10.88 30 143646 3584 110442039
Intentional self-injury 30.08 10.88 6 143670 37423 110408200
Therapy partial responder 29.66 10.88 6 143670 37055 110408568
Finger deformity 29.50 10.88 4 143672 33088 110412535
Antacid therapy 29.45 10.88 36 143640 5448 110440175
Liver disorder 29.37 10.88 91 143585 142152 110303471
Suicide attempt 29.35 10.88 56 143620 103338 110342285
Sleep disorder therapy 29.24 10.88 42 143634 7429 110438194
Cardiovascular disorder 29.20 10.88 80 143596 22680 110422943
Arrhythmia 29.07 10.88 172 143504 69403 110376220
Haematuria 28.97 10.88 196 143480 82809 110362814
Therapy non-responder 28.82 10.88 106 143570 157201 110288422
Post procedural complication 28.70 10.88 88 143588 26570 110419053
Osteoporosis 28.61 10.88 43 143633 87109 110358514
Analgesic therapy 28.58 10.88 41 143635 7243 110438380
Non-cardiac chest pain 28.34 10.88 49 143627 10149 110435474
Amaurosis fugax 28.19 10.88 24 143652 2366 110443257
Coronary ostial stenosis 28.12 10.88 10 143666 164 110445459
Paraesthesia 28.10 10.88 227 143449 276294 110169329
Sinus arrest 28.06 10.88 31 143645 4211 110441412
Lupus-like syndrome 28.05 10.88 9 143667 40783 110404840
Tremor 28.04 10.88 393 143283 201839 110243784
Hyperhidrosis 28.03 10.88 369 143307 186929 110258694
Herpes zoster 27.97 10.88 62 143614 108317 110337306
Micturition urgency 27.93 10.88 71 143605 19249 110426374
Carotid artery stenosis 27.72 10.88 46 143630 9217 110436406
Pyrexia 27.48 10.88 924 142752 897341 109548282
Bronchial irritation 27.47 10.88 8 143668 66 110445557
Onychomycosis 27.40 10.88 8 143668 38523 110407100
Stent placement 27.34 10.88 40 143636 7194 110438429
Middle insomnia 27.24 10.88 73 143603 20429 110425194
Neuropathy peripheral 27.14 10.88 130 143546 179147 110266476
Myalgia 26.86 10.88 422 143254 221959 110223664
Tricuspid valve incompetence 26.83 10.88 80 143596 23793 110421830
Multiple organ dysfunction syndrome 26.63 10.88 308 143368 151402 110294221
Vascular stent occlusion 26.49 10.88 11 143665 279 110445344
Injection site pruritus 26.39 10.88 17 143659 51241 110394382
Blood creatine phosphokinase increased 26.37 10.88 174 143502 72903 110372720
Essential hypertension 26.26 10.88 41 143635 7806 110437817
Drug-induced liver injury 26.09 10.88 75 143601 119992 110325631
Psoriasis 25.86 10.88 94 143582 139899 110305724
Lower gastrointestinal haemorrhage 25.76 10.88 67 143609 18419 110427204
Hepatic function abnormal 25.67 10.88 48 143628 89247 110356376
Hypovolaemia 25.67 10.88 74 143602 21600 110424023
Atrioventricular block 25.43 10.88 63 143613 16814 110428809
Atrioventricular block complete 25.18 10.88 70 143606 20012 110425611
Activated partial thromboplastin time prolonged 25.18 10.88 75 143601 22293 110423330
Loss of personal independence in daily activities 24.99 10.88 105 143571 149915 110295708
Atrioventricular block second degree 24.98 10.88 41 143635 8140 110437483
Palmar-plantar erythrodysaesthesia syndrome 24.95 10.88 11 143665 41014 110404609
Bundle branch block left 24.82 10.88 53 143623 12835 110432788
No adverse event 24.66 10.88 36 143640 73803 110371820
Joint stiffness 24.25 10.88 31 143645 67212 110378411
Cardiac procedure complication 24.00 10.88 11 143665 356 110445267
Swollen tongue 23.80 10.88 147 143529 60215 110385408
Colitis 23.79 10.88 220 143456 102103 110343520
Bone marrow failure 23.77 10.88 24 143652 57824 110387799
Adverse event 23.62 10.88 68 143608 108741 110336882
Bronchopulmonary aspergillosis 23.56 10.88 5 143671 29858 110415765
Palpitations 23.54 10.88 313 143363 158899 110286724
Postoperative renal failure 23.52 10.88 9 143667 183 110445440
Lymphadenopathy 23.47 10.88 29 143647 63806 110381817
Superinfection 23.44 10.88 33 143643 5730 110439893
Cardiomyopathy 23.44 10.88 96 143580 33429 110412194
Arthritis 23.39 10.88 125 143551 167461 110278162
Myasthenia gravis 23.15 10.88 71 143605 21440 110424183
Cold sweat 23.05 10.88 72 143604 21959 110423664
Base excess decreased 22.99 10.88 11 143665 393 110445230
Drug therapy 22.89 10.88 37 143639 7254 110438369
Completed suicide 22.82 10.88 203 143473 242178 110203445
Back injury 22.71 10.88 17 143659 47382 110398241
Neuroleptic malignant syndrome 22.57 10.88 8 143668 34051 110411572
Full blood count abnormal 22.42 10.88 137 143539 55915 110389708
Progressive multifocal leukoencephalopathy 22.29 10.88 3 143673 24953 110420670
Thrombocytopenia 22.27 10.88 319 143357 348566 110097057
Pneumocystis jirovecii pneumonia 22.24 10.88 14 143662 42721 110402902
International normalised ratio decreased 22.14 10.88 39 143637 8197 110437426
Platelet count decreased 22.13 10.88 192 143484 230251 110215372
Orthopnoea 22.01 10.88 46 143630 10975 110434648
Cough 22.01 10.88 769 142907 460872 109984751
Oedema 21.97 10.88 171 143505 209805 110235818
Blood glucose increased 21.93 10.88 266 143410 132230 110313393
Coronary artery reocclusion 21.91 10.88 8 143668 142 110445481
Feeling abnormal 21.85 10.88 343 143333 180368 110265255
Dry mouth 21.78 10.88 161 143515 199787 110245836
Head injury 21.76 10.88 112 143564 42905 110402718
Vascular pseudoaneurysm 21.68 10.88 27 143649 4163 110441460
Bladder disorder 21.68 10.88 46 143630 11091 110434532
Frequent bowel movements 21.67 10.88 163 143513 71227 110374396
Haemophagocytic lymphohistiocytosis 21.63 10.88 7 143669 31552 110414071
Intraventricular haemorrhage 21.61 10.88 31 143645 5476 110440147
Oral herpes 21.43 10.88 10 143666 36070 110409553
Benign prostatic hyperplasia 21.35 10.88 62 143614 18172 110427451
Abdominal rigidity 21.14 10.88 25 143651 3655 110441968
Ventricular hypertrophy 21.10 10.88 35 143641 7010 110438613
Renin increased 20.94 10.88 10 143666 356 110445267
Gastritis 20.69 10.88 130 143546 53569 110392054
Subdural haematoma 20.63 10.88 98 143578 36356 110409267
Septic shock 20.62 10.88 120 143556 157408 110288215
Blood urea increased 20.53 10.88 132 143544 54825 110390798
Productive cough 20.48 10.88 233 143443 114072 110331551
Pancytopenia 20.42 10.88 174 143502 209439 110236184
Dizziness postural 20.41 10.88 53 143623 14556 110431067
Gastric ulcer 20.36 10.88 104 143572 39723 110405900
Drug resistance 20.32 10.88 26 143650 56348 110389275
Haemorrhagic stroke 20.28 10.88 51 143625 13738 110431885
Nerve degeneration 20.06 10.88 9 143667 277 110445346
Left ventricular failure 19.85 10.88 45 143631 11344 110434279
Hyperthyroidism 19.83 10.88 83 143593 29178 110416445
Heparin-induced thrombocytopenia 19.76 10.88 45 143631 11379 110434244
Laryngeal haematoma 19.68 10.88 8 143668 192 110445431
Hypertensive crisis 19.65 10.88 73 143603 24299 110421324
Ear infection 19.59 10.88 32 143644 62700 110382923
Supraventricular tachycardia 19.56 10.88 73 143603 24349 110421274
Silent myocardial infarction 19.54 10.88 12 143664 709 110444914
Ecchymosis 19.39 10.88 58 143618 17280 110428343
Hepatotoxicity 19.19 10.88 33 143643 63367 110382256
Acute myeloid leukaemia 19.13 10.88 13 143663 38097 110407526
Faeces discoloured 19.02 10.88 91 143585 33857 110411766
Hypomagnesaemia 18.99 10.88 139 143537 60231 110385392
Eczema 18.95 10.88 41 143635 72252 110373371
Product complaint 18.82 10.88 50 143626 13922 110431701
Normochromic anaemia 18.81 10.88 11 143665 594 110445029
End stage renal disease 18.74 10.88 66 143610 21407 110424216
Lymphoedema 18.68 10.88 52 143624 14877 110430746
Cardiogenic shock 18.60 10.88 133 143543 57205 110388418
Arterial stenosis 18.57 10.88 16 143660 1603 110444020
Transplant failure 18.24 10.88 29 143647 5606 110440017
Hepatorenal syndrome 18.22 10.88 26 143650 4571 110441052
Drug eruption 18.08 10.88 26 143650 53633 110391990
Asthenia 18.02 10.88 1080 142596 687919 109757704
Autonomic dysreflexia 18.01 10.88 10 143666 489 110445134
Coronary steal syndrome 17.89 10.88 4 143672 9 110445614
Coronary artery dissection 17.80 10.88 14 143662 1234 110444389
Ear pain 17.72 10.88 26 143650 53200 110392423
Metastases to central nervous system 17.63 10.88 4 143672 22813 110422810
Mouth ulceration 17.56 10.88 22 143654 48116 110397507
Oxygen consumption decreased 17.48 10.88 10 143666 518 110445105
Thrombotic microangiopathy 17.44 10.88 8 143668 29141 110416482
Acne 17.42 10.88 11 143665 33509 110412114
Aplastic anaemia 17.37 10.88 5 143671 24303 110421320
Extrapyramidal disorder 17.15 10.88 8 143668 28859 110416764
Blood creatine phosphokinase MB increased 17.14 10.88 20 143656 2883 110442740
Epistaxis 17.13 10.88 251 143425 130121 110315502
Dilatation atrial 17.08 10.88 23 143653 3829 110441794
Coagulation time prolonged 17.06 10.88 20 143656 2897 110442726
Breast cancer 17.00 10.88 15 143661 38527 110407096
Vascular graft occlusion 16.90 10.88 11 143665 720 110444903
Hypoxia 16.87 10.88 249 143427 129266 110316357
Pyuria 16.82 10.88 19 143657 2644 110442979
Foot deformity 16.82 10.88 23 143653 48457 110397166
Illness 16.65 10.88 53 143623 82118 110363505
Abdominal wall haematoma 16.63 10.88 28 143648 5677 110439946
Normal newborn 16.60 10.88 4 143672 21892 110423731
Tinnitus 16.60 10.88 135 143541 60405 110385218
Ventricular asystole 16.59 10.88 9 143667 420 110445203
Atrial flutter 16.58 10.88 69 143607 24193 110421430
Craniocervical syndrome 16.57 10.88 6 143670 104 110445519
Laryngotracheal oedema 16.50 10.88 5 143671 48 110445575
Adverse reaction 16.38 10.88 9 143667 29585 110416038
Left ventricular dysfunction 16.21 10.88 67 143609 23426 110422197
Hiatus hernia 16.20 10.88 75 143601 27531 110418092
Coronary no-reflow phenomenon 16.17 10.88 4 143672 16 110445607
Ventricular hyperkinesia 16.05 10.88 8 143668 313 110445310
Blood chloride decreased 15.87 10.88 36 143640 9079 110436544
Hepatic cirrhosis 15.62 10.88 41 143635 67585 110378038
Diverticulum 15.56 10.88 50 143626 15476 110430147
Candida infection 15.46 10.88 24 143652 47985 110397638
Device malfunction 15.42 10.88 70 143606 25488 110420135
Hospitalisation 15.39 10.88 115 143561 142378 110303245
Cerebral haemorrhage 15.26 10.88 140 143536 64828 110380795
Generalised tonic-clonic seizure 15.18 10.88 30 143646 54650 110390973
Respiration abnormal 15.18 10.88 37 143639 9772 110435851
Pneumococcal infection 15.08 10.88 15 143661 1804 110443819
Ureteric injury 15.04 10.88 6 143670 137 110445486
Hepatitis 15.01 10.88 63 143613 89991 110355632
Renal neoplasm 14.92 10.88 17 143659 2389 110443234
Aortic stenosis 14.90 10.88 44 143632 13015 110432608
Fear of eating 14.85 10.88 9 143667 519 110445104
Vasospasm 14.81 10.88 14 143662 1582 110444041
Carotid artery occlusion 14.72 10.88 36 143640 9529 110436094
Hallucination, visual 14.71 10.88 95 143581 39510 110406113
Lethargy 14.68 10.88 186 143490 93390 110352233
Flushing 14.68 10.88 78 143598 104658 110340965
Left ventricular end-diastolic pressure increased 14.65 10.88 10 143666 708 110444915
Injection site swelling 14.62 10.88 37 143639 61753 110383870
Ulcer 14.56 10.88 101 143575 43015 110402608
Musculoskeletal stiffness 14.48 10.88 266 143410 279556 110166067
Hyperkeratosis 14.46 10.88 35 143641 9204 110436419
Gastrooesophageal reflux disease 14.25 10.88 320 143356 179656 110265967
Gastritis erosive 14.24 10.88 41 143635 11959 110433664
Haemorrhoidal haemorrhage 14.13 10.88 32 143644 8061 110437562
Adverse drug reaction 14.03 10.88 80 143596 105479 110340144
Neoplasm skin 14.01 10.88 19 143657 3185 110442438
Coronary bypass thrombosis 14.01 10.88 3 143673 5 110445618
Hyperphosphataemia 13.99 10.88 50 143626 16331 110429292
Upper respiratory tract infection 13.93 10.88 244 143432 131084 110314539
Brain stem stroke 13.90 10.88 10 143666 771 110444852
Diabetic neuropathy 13.73 10.88 29 143647 6970 110438653
Morning glory syndrome 13.65 10.88 3 143673 6 110445617
Post procedural haematoma 13.65 10.88 17 143659 2622 110443001
Facial paralysis 13.63 10.88 65 143611 24149 110421474
Febrile bone marrow aplasia 13.62 10.88 3 143673 17462 110428161
Tumour lysis syndrome 13.57 10.88 12 143664 30789 110414834
Extrasystoles 13.55 10.88 32 143644 8286 110437337
Disorientation 13.55 10.88 146 143530 70525 110375098
Product impurity 13.38 10.88 5 143671 95 110445528
Peripheral ischaemia 13.33 10.88 38 143638 11020 110434603
Reperfusion arrhythmia 13.31 10.88 7 143669 307 110445316
Memory impairment 13.30 10.88 178 143498 196766 110248857
Pituitary apoplexy 13.29 10.88 7 143669 308 110445315
Haemorrhagic transformation stroke 13.27 10.88 18 143658 3019 110442604
Chromaturia 13.19 10.88 74 143602 29286 110416337
Joint dislocation 13.14 10.88 15 143661 34175 110411448
Coagulation time abnormal 13.13 10.88 6 143670 193 110445430
Loss of consciousness 13.11 10.88 341 143335 195965 110249658
Vision blurred 13.07 10.88 238 143438 128784 110316839
Cardiac murmur 13.07 10.88 65 143611 24563 110421060
Nodal rhythm 13.04 10.88 19 143657 3404 110442219
Schizophrenia 13.04 10.88 6 143670 21820 110423803
Infarction 12.95 10.88 24 143652 5245 110440378
Left ventricular enlargement 12.92 10.88 10 143666 861 110444762
Finger amputation 12.90 10.88 10 143666 863 110444760
Urea renal clearance decreased 12.87 10.88 4 143672 42 110445581
Wound secretion 12.85 10.88 28 143648 6873 110438750
Subarachnoid haemorrhage 12.78 10.88 74 143602 29628 110415995
Multiple sclerosis relapse 12.75 10.88 29 143647 50211 110395412
Nephrogenic anaemia 12.73 10.88 22 143654 4555 110441068
Food allergy 12.69 10.88 5 143671 19943 110425680
Vomiting 12.66 10.88 1015 142661 909660 109535963
Transaminases increased 12.64 10.88 132 143544 63258 110382365
Vulvovaginal mycotic infection 12.61 10.88 24 143652 5353 110440270
Myocardial necrosis marker increased 12.61 10.88 20 143656 3860 110441763
Carotid artery disease 12.60 10.88 15 143661 2208 110443415
Cardioactive drug level increased 12.60 10.88 20 143656 3862 110441761
Subacute cutaneous lupus erythematosus 12.60 10.88 23 143653 4971 110440652
Diabetes mellitus 12.53 10.88 190 143486 99191 110346432
Cardiac failure chronic 12.53 10.88 43 143633 13768 110431855
Device related infection 12.49 10.88 20 143656 39499 110406124
Diastolic dysfunction 12.48 10.88 40 143636 12364 110433259
Fear of death 12.47 10.88 13 143663 1654 110443969
Cardiac failure acute 12.39 10.88 63 143613 24015 110421608
Nephrogenic systemic fibrosis 12.28 10.88 24 143652 5459 110440164
Torsade de pointes 12.24 10.88 60 143616 22540 110423083
Mental status changes 12.24 10.88 152 143524 75970 110369653
Oral mucosal eruption 12.24 10.88 11 143665 1166 110444457
Immune reconstitution inflammatory syndrome 12.23 10.88 3 143673 16223 110429400
Appetite disorder 12.20 10.88 34 143642 9735 110435888
Dyslipidaemia 12.19 10.88 47 143629 15918 110429705
Bacteriuria 12.19 10.88 12 143664 1426 110444197
Coronary artery compression 12.13 10.88 3 143673 12 110445611
Puncture site reaction 12.13 10.88 3 143673 12 110445611
Alanine aminotransferase increased 12.08 10.88 167 143509 183606 110262017
Mitral valve calcification 12.08 10.88 13 143663 1715 110443908
Device leakage 12.03 10.88 3 143673 16045 110429578
Walking aid user 12.00 10.88 9 143667 25066 110420557
Aortic aneurysm 11.91 10.88 34 143642 9870 110435753
Blood potassium increased 11.89 10.88 79 143597 33170 110412453
Dilatation ventricular 11.88 10.88 20 143656 4055 110441568
Cytopenia 11.81 10.88 13 143663 30103 110415520
Drug dependence 11.80 10.88 30 143646 49990 110395633
Therapeutic product effect delayed 11.77 10.88 21 143655 4458 110441165
Colitis ischaemic 11.76 10.88 50 143626 17700 110427923
Miosis 11.72 10.88 7 143669 21976 110423647
Skin cancer 11.71 10.88 50 143626 17734 110427889
Therapy interrupted 11.66 10.88 30 143646 49792 110395831
Muscle necrosis 11.66 10.88 13 143663 1784 110443839
Enterocolitis 11.65 10.88 5 143671 18944 110426679
Arterial occlusive disease 11.64 10.88 45 143631 15263 110430360
Cerebral mass effect 11.59 10.88 15 143661 2404 110443219
Vascular stent stenosis 11.57 10.88 12 143664 1517 110444106
Muscle spasticity 11.52 10.88 18 143658 35897 110409726
Oesophageal carcinoma 11.45 10.88 37 143639 11487 110434136
Duodenal ulcer 11.44 10.88 53 143623 19461 110426162
Metastases to lung 11.40 10.88 8 143668 23055 110422568
Device issue 11.37 10.88 17 143659 34518 110411105
Eating disorder 11.36 10.88 14 143662 30844 110414779
Palmoplantar keratoderma 11.36 10.88 23 143653 5364 110440259
Coronary angioplasty 11.36 10.88 7 143669 416 110445207
QRS axis abnormal 11.35 10.88 15 143661 2453 110443170
Therapeutic response shortened 11.34 10.88 13 143663 29570 110416053
Chronic left ventricular failure 11.33 10.88 11 143665 1285 110444338
Hypervolaemia 11.32 10.88 106 143570 49354 110396269
Body temperature increased 11.29 10.88 35 143641 54678 110390945
Fatigue 11.25 10.88 1396 142280 1214562 109231061
Dehydration 11.23 10.88 457 143219 279054 110166569
Total cholesterol/HDL ratio decreased 11.23 10.88 4 143672 66 110445557
Depressive symptom 11.22 10.88 30 143646 8384 110437239
Osteonecrosis of jaw 11.17 10.88 29 143647 47988 110397635
Increased viscosity of upper respiratory secretion 11.03 10.88 8 143668 624 110444999
Gastrointestinal tract irritation 11.03 10.88 9 143667 836 110444787
Peptic ulcer 11.02 10.88 28 143648 7591 110438032
Colitis ulcerative 10.98 10.88 151 143525 77212 110368411
Allergic eosinophilia 10.91 10.88 4 143672 72 110445551
Aphthous ulcer 10.89 10.88 7 143669 21129 110424494

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01DA02 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
VASODILATORS USED IN CARDIAC DISEASES
Organic nitrates
ATC C01DA52 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
VASODILATORS USED IN CARDIAC DISEASES
Organic nitrates
ATC C05AE01 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Muscle relaxants
FDA CS M0014874 Nitrates
FDA PE N0000009909 Vasodilation
FDA EPC N0000175415 Nitrate Vasodilator
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014665 Vasodilator Agents
MeSH PA D053834 Explosive Agents
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35620 vasodilator agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:50566 nitric oxide donor
CHEBI has role CHEBI:50646 bone density conservation agent
CHEBI has role CHEBI:51371 muscle relaxant
CHEBI has role CHEBI:63490 explosive
CHEBI has role CHEBI:66993 tocolytic agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:73336 vulnerary

Related Drugs by ATC class:

C01DA Organic nitrates 7 drugs
eritrityl tetranitrateisosorbide dinitrateisosorbide mononitratepentaerithrityl tetranitratepropatylnitratetenitraminetrolnitrate
C05AE Muscle relaxants 2 drugs
diltiazemisosorbide dinitrate

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Angina pectoris indication 194828000
Left ventricular cardiac dysfunction indication 429589006
Perioperative hypertension indication 434711000124103
Angina Pectoris Prevention indication
Myocardial infarction off-label use 22298006 DOID:5844
Anal fissure off-label use 30037006
Decompensated cardiac failure off-label use 195111005
Extravasation injury off-label use 371100002
Acute coronary syndrome off-label use 394659003
Hypertensive urgency off-label use 443482000
Hypovolemia contraindication 28560003
Cardiac tamponade contraindication 35304003 DOID:115
Methemoglobinemia contraindication 38959009 DOID:10783
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Injury of head contraindication 82271004
Constrictive pericarditis contraindication 85598007 DOID:11481
Hypertrophic cardiomyopathy contraindication 233873004 DOID:11984
Anemia contraindication 271737000 DOID:2355
Cerebral hemorrhage contraindication 274100004
Restrictive cardiomyopathy contraindication 415295002 DOID:397




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.4MG/SPRAY NITROLINGUAL PUMPSPRAY POHL BOSKAMP N018705 Jan. 10, 1997 RX SPRAY, METERED SUBLINGUAL 7872049 March 12, 2029 METHOD OF TREATING ANGINA PECTORIS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Soluble guanylate cyclase Enzyme ACTIVATOR CHEMBL CHEMBL
Atrial natriuretic peptide receptor 1 Enzyme WOMBAT-PK

External reference:

IDSource
4017525 VUID
N0000145909 NUI
D00515 KEGG_DRUG
4017525 VANDF
CHEBI:28787 CHEBI
TNG PDB_CHEM_ID
CHEMBL730 ChEMBL_ID
DB00727 DRUGBANK_ID
4917 RXNORM
2324 MMSL
5183 MMSL
d00321 MMSL
000683 NDDF
387404004 SNOMEDCT_US
71759000 SNOMEDCT_US
C0017887 UMLSCUI
D005996 MESH_DESCRIPTOR_UI
4510 PUBCHEM_CID
7053 IUPHAR_LIGAND_ID
G59M7S0WS3 UNII
G59M7S0WS3 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Minitran HUMAN PRESCRIPTION DRUG LABEL 1 0089-0171 PATCH 18 mg TRANSDERMAL Export only 1 sections
Minitran HUMAN PRESCRIPTION DRUG LABEL 1 0089-0172 PATCH 36 mg TRANSDERMAL Export only 1 sections
Minitran HUMAN PRESCRIPTION DRUG LABEL 1 0089-0173 PATCH 54 mg TRANSDERMAL Export only 1 sections
NITRO-BID HUMAN PRESCRIPTION DRUG LABEL 1 0281-0326 OINTMENT 20 mg TOPICAL ANDA 21 sections
Nitroglycerin In Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0338-1047 INJECTION 10 mg INTRAVENOUS NDA 20 sections
Nitroglycerin In Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0338-1049 INJECTION 20 mg INTRAVENOUS NDA 20 sections
Nitroglycerin In Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0338-1051 INJECTION 40 mg INTRAVENOUS NDA 20 sections
Nitroglycerin HUMAN PRESCRIPTION DRUG LABEL 1 0378-9102 PATCH 0.10 mg TRANSDERMAL ANDA 21 sections
Nitroglycerin HUMAN PRESCRIPTION DRUG LABEL 1 0378-9104 PATCH 0.20 mg TRANSDERMAL ANDA 21 sections
Nitroglycerin HUMAN PRESCRIPTION DRUG LABEL 1 0378-9112 PATCH 0.40 mg TRANSDERMAL ANDA 21 sections
Nitroglycerin HUMAN PRESCRIPTION DRUG LABEL 1 0378-9116 PATCH 0.60 mg TRANSDERMAL ANDA 21 sections
NITROSTAT HUMAN PRESCRIPTION DRUG LABEL 1 0404-9800 TABLET 0.40 mg SUBLINGUAL NDA 16 sections
NITROSTAT HUMAN PRESCRIPTION DRUG LABEL 1 0404-9800 TABLET 0.40 mg SUBLINGUAL NDA 16 sections
Nitroglycerin HUMAN PRESCRIPTION DRUG LABEL 1 0404-9928 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 11 sections
Nitroglycerin HUMAN PRESCRIPTION DRUG LABEL 1 0404-9928 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 11 sections
Nitroglycerin HUMAN PRESCRIPTION DRUG LABEL 1 0517-4810 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 21 sections
NITROGLYCERIN HUMAN PRESCRIPTION DRUG LABEL 1 0713-0564 OINTMENT 4 mg RECTAL ANDA 27 sections
Nitrostat HUMAN PRESCRIPTION DRUG LABEL 1 21695-450 TABLET 0.40 mg SUBLINGUAL NDA 23 sections
Nitroglycerin Slocaps HUMAN PRESCRIPTION DRUG LABEL 1 21695-635 CAPSULE 2.50 mg ORAL Unapproved drug other 19 sections
Nitroglycerin Slocaps HUMAN PRESCRIPTION DRUG LABEL 1 21695-636 CAPSULE 6.50 mg ORAL Unapproved drug other 19 sections
Nitroglycerin HUMAN PRESCRIPTION DRUG LABEL 1 21695-810 TABLET 0.40 mg ORAL Unapproved drug other 23 sections
NITROLINGUAL HUMAN PRESCRIPTION DRUG LABEL 1 21724-100 SPRAY 400 ug ORAL NDA 26 sections
NITROGLYCERIN HUMAN PRESCRIPTION DRUG LABEL 1 21922-048 OINTMENT 4 mg RECTAL ANDA 26 sections
NITROGLYCERIN Human Prescription Drug Label 1 21922-054 OINTMENT 20 mg TOPICAL ANDA 19 sections
NITROGLYCERIN Human Prescription Drug Label 1 21922-054 OINTMENT 20 mg TOPICAL ANDA 19 sections
NITROGLYCERIN LINGUAL HUMAN PRESCRIPTION DRUG LABEL 1 28595-120 SPRAY 400 ug ORAL NDA authorized generic 26 sections
Minitran HUMAN PRESCRIPTION DRUG LABEL 1 29336-301 PATCH 2.50 mg TRANSDERMAL ANDA 21 sections
Minitran HUMAN PRESCRIPTION DRUG LABEL 1 29336-302 PATCH 5 mg TRANSDERMAL ANDA 21 sections
Minitran HUMAN PRESCRIPTION DRUG LABEL 1 29336-303 PATCH 10 mg TRANSDERMAL ANDA 21 sections
Minitran HUMAN PRESCRIPTION DRUG LABEL 1 29336-304 PATCH 15 mg TRANSDERMAL ANDA 21 sections