isosorbide dinitrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
NO2 - derivatives	1505	87-33-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: r-isosorbide dinitrate vascardin astridine isosorbide dinitrate	A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action. Molecular weight: 236.14 Formula: C6H8N2O8 CLOGP: -0.08 LIPINSKI: 0 HAC: 10 HDO: 0 TPSA: 128.56 ALOGS: -2.40 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

r-isosorbide dinitrate
vascardin
astridine
isosorbide dinitrate

A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.

Molecular weight: 236.14
Formula: C6H8N2O8
CLOGP: -0.08
LIPINSKI: 0
HAC: 10
HDO: 0
TPSA: 128.56
ALOGS: -2.40
ROTB: 4

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
60	mg	O
20	mg	oral aerosol
20	mg	SL
0.10	g	TD

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	1.09 mg/mL	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	7.26 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	22 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	1.90 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	31 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.72 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	1.70 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Jan. 16, 1968	FDA	ASTRAZENECA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Myocardial infarction	239.62	13.39	222	20252	99671	63368877
Cardiospasm	183.88	13.39	53	20421	1854	63466694
Subarachnoid haemorrhage	182.31	13.39	90	20384	14193	63454355
Palmoplantar keratoderma	181.20	13.39	53	20421	1954	63466594
Cardiac failure congestive	177.66	13.39	182	20292	92251	63376297
Pruritus genital	166.60	13.39	53	20421	2601	63465947
Sleep terror	166.09	13.39	53	20421	2627	63465921
Carotid artery occlusion	158.71	13.39	59	20415	4635	63463913
Atrial tachycardia	145.95	13.39	54	20420	4186	63464362
Tension headache	138.86	13.39	55	20419	5131	63463417
Anosmia	117.62	13.39	53	20421	6807	63461741
Immunisation	114.32	13.39	33	20441	1160	63467388
Ventricular tachycardia	113.20	13.39	74	20400	19905	63448643
Transient ischaemic attack	102.36	13.39	90	20384	37663	63430885
Facial pain	95.94	13.39	53	20421	10508	63458040
Chest pain	95.26	13.39	213	20261	215746	63252802
Pain of skin	93.82	13.39	54	20420	11580	63456968
Drug ineffective	83.22	13.39	131	20343	1044634	62423914
Vasculitis	83.07	13.39	59	20415	18150	63450398
Hallucination	82.58	13.39	95	20379	54722	63413826
Muscle twitching	79.00	13.39	59	20415	19609	63448939
Blindness	78.15	13.39	61	20413	21638	63446910
Eye pruritus	74.97	13.39	56	20418	18615	63449933
Intentional product misuse	74.51	13.39	95	20379	60822	63407726
Coronary artery disease	68.07	13.39	67	20407	32310	63436238
Acute myocardial infarction	66.65	13.39	66	20408	32058	63436490
Diplopia	65.17	13.39	57	20417	23671	63444877
Lip swelling	53.93	13.39	58	20416	31005	63437543
Blood glucose increased	52.87	13.39	96	20378	83660	63384888
Treatment failure	52.09	13.39	3	20471	199040	63269508
Contraindicated product administered	52.08	13.39	5	20469	217643	63250905
Generalised bullous fixed drug eruption	52.05	13.39	11	20463	100	63468448
Joint swelling	50.91	13.39	21	20453	327645	63140903
Infusion related reaction	50.73	13.39	9	20465	245512	63223036
Angina unstable	49.51	13.39	30	20444	7065	63461483
Systemic lupus erythematosus	49.46	13.39	5	20469	208913	63259635
Angioedema	48.23	13.39	68	20406	47897	63420651
Arthropathy	47.66	13.39	9	20465	234783	63233765
Bradycardia	47.57	13.39	85	20389	73142	63395406
Tinnitus	47.45	13.39	58	20416	35570	63432978
Visual impairment	47.34	13.39	92	20382	84354	63384194
Angina pectoris	46.75	13.39	53	20421	30025	63438523
Dry skin	46.24	13.39	73	20401	56814	63411734
Cardiac failure	46.22	13.39	94	20380	89048	63379500
Glossodynia	45.89	13.39	3	20471	178873	63289675
Therapeutic product effect decreased	44.77	13.39	5	20469	193182	63275366
Amnesia	44.72	13.39	71	20403	55514	63413034
Maternal exposure during pregnancy	43.48	13.39	9	20465	220053	63248495
Hepatic enzyme increased	42.70	13.39	7	20467	202321	63266227
Disturbance in attention	42.70	13.39	57	20417	38132	63430416
Drug intolerance	41.54	13.39	24	20450	308637	63159911
Rash papular	39.70	13.39	36	20438	15666	63452882
Dehydration	36.60	13.39	131	20343	173223	63295325
Myocardial ischaemia	35.53	13.39	31	20443	12828	63455720
Cerebrovascular accident	35.23	13.39	95	20379	107929	63360619
Swelling	33.51	13.39	24	20450	275354	63193194
Product use issue	32.85	13.39	15	20459	220505	63248043
Cognitive disorder	31.50	13.39	61	20413	55754	63412794
Discomfort	30.75	13.39	8	20466	167366	63301182
Renal failure	30.22	13.39	95	20379	117557	63350991
Hyperhidrosis	29.48	13.39	89	20385	107747	63360801
Palpitations	27.99	13.39	90	20384	112680	63355868
Hypersensitivity	27.87	13.39	32	20442	292653	63175895
Infection	27.83	13.39	20	20454	229153	63239395
Nasopharyngitis	27.38	13.39	25	20449	254232	63214316
Acute kidney injury	27.03	13.39	161	20313	263254	63205294
Haemorrhagic diathesis	26.59	13.39	17	20457	4398	63464150
Arteriospasm coronary	25.70	13.39	16	20458	3952	63464596
Rheumatoid arthritis	23.89	13.39	28	20446	253791	63214757
Lower respiratory tract infection	23.05	13.39	7	20467	132300	63336248
Red cell distribution width abnormal	22.78	13.39	6	20468	149	63468399
Coronary arterial stent insertion	22.45	13.39	13	20461	2816	63465732
Dysphoria	22.43	13.39	16	20458	4950	63463598
Mesenteric arterial occlusion	22.30	13.39	6	20468	162	63468386
Heart rate increased	22.29	13.39	74	20400	94164	63374384
Sinus bradycardia	21.53	13.39	25	20449	14526	63454022
Wound	21.51	13.39	13	20461	163250	63305298
Renal impairment	21.45	13.39	70	20404	88285	63380263
Tachycardia	21.36	13.39	85	20389	118071	63350477
Dyspnoea	20.60	13.39	313	20161	661000	62807548
Muscular weakness	20.52	13.39	86	20388	122267	63346281
Feeling abnormal	19.45	13.39	97	20377	148295	63320253
Left ventricular hypertrophy	19.26	13.39	15	20459	5300	63463248
Ischaemic cardiomyopathy	18.65	13.39	11	20463	2466	63466082
Electrocardiogram ST segment elevation	18.54	13.39	13	20461	3914	63464634
Exposure during pregnancy	18.33	13.39	14	20460	155533	63313015
Gamma-glutamyltransferase abnormal	18.14	13.39	6	20468	333	63468215
Lip erosion	18.07	13.39	8	20466	985	63467563
Hyperkalaemia	17.99	13.39	48	20426	54155	63414393
Chronic kidney disease	17.99	13.39	43	20431	45355	63423193
N-terminal prohormone brain natriuretic peptide abnormal	17.92	13.39	4	20470	48	63468500
Mucosal erosion	17.71	13.39	9	20465	1507	63467041
Blood urea increased	17.61	13.39	31	20443	26348	63442200
Psoriatic arthropathy	17.54	13.39	4	20470	91516	63377032
Genital erosion	17.48	13.39	5	20469	170	63468378
Memory impairment	17.26	13.39	73	20401	104185	63364363
Hypovolaemic shock	17.15	13.39	15	20459	6226	63462322
Blood pressure decreased	17.14	13.39	53	20421	64969	63403579
Irritable bowel syndrome	17.05	13.39	3	20471	82409	63386139
Insulin C-peptide increased	16.51	13.39	4	20470	70	63468478
Dizziness	16.38	13.39	211	20263	429714	63038834
COVID-19	16.31	13.39	76	20398	113027	63355521
BRASH syndrome	16.24	13.39	6	20468	463	63468085
Gynaecomastia	16.04	13.39	5	20469	229	63468319
Acute coronary syndrome	16.00	13.39	18	20456	10108	63458440
Haematocrit abnormal	15.67	13.39	7	20467	880	63467668
Sinusitis	15.55	13.39	31	20443	226622	63241926
Coronary artery occlusion	15.47	13.39	16	20458	8175	63460373
Off label use	15.10	13.39	142	20332	674320	62794228
Cardiac failure chronic	15.00	13.39	12	20462	4406	63464142
Shock	14.92	13.39	27	20447	23436	63445112
Blood creatinine increased	14.92	13.39	62	20412	87782	63380766
Nephrogenic systemic fibrosis	14.67	13.39	12	20462	4544	63464004
Fibromyalgia	14.47	13.39	4	20470	80416	63388132
Respiratory acidosis	14.30	13.39	14	20460	6701	63461847
Coronary artery stenosis	14.25	13.39	12	20462	4732	63463816
Hypotension	14.07	13.39	142	20332	272462	63196086
Paraesthesia	14.03	13.39	18	20456	156948	63311600
Renal hypoplasia	13.94	13.39	3	20471	30	63468518
Cardiac disorder	13.93	13.39	42	20432	50774	63417774
Arrhythmia	13.92	13.39	35	20439	38105	63430443
Migraine	13.85	13.39	68	20406	103278	63365270
Therapeutic product effect incomplete	13.80	13.39	12	20462	125044	63343504
Silent myocardial infarction	13.69	13.39	5	20469	373	63468175
Rhabdomyolysis	13.66	13.39	38	20436	43913	63424635
Febrile neutropenia	13.52	13.39	11	20463	118438	63350110
Drug hypersensitivity	13.50	13.39	53	20421	310634	63157914

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Myocardial infarction	208.25	13.03	318	22195	120767	34813651
Cardiospasm	197.71	13.03	63	22450	1525	34932893
Palmoplantar keratoderma	181.00	13.03	62	22451	1891	34932527
Cardiac failure congestive	172.56	13.03	239	22274	83031	34851387
Pruritus genital	169.90	13.03	61	22452	2143	34932275
Sleep terror	166.89	13.03	61	22452	2257	34932161
Tension headache	161.17	13.03	64	22449	2978	34931440
Atrial tachycardia	156.64	13.03	66	22447	3579	34930839
Facial pain	152.30	13.03	65	22448	3639	34930779
Carotid artery occlusion	145.18	13.03	63	22450	3674	34930744
Anosmia	143.90	13.03	64	22449	3960	34930458
Immunisation	135.20	13.03	43	22470	1034	34933384
Chest pain	125.87	13.03	262	22251	126500	34807918
Pain of skin	112.97	13.03	62	22451	6047	34928371
Subarachnoid haemorrhage	97.60	13.03	74	22439	12561	34921857
Eye pruritus	96.15	13.03	60	22453	7429	34926989
Ventricular tachycardia	92.01	13.03	99	22414	26480	34907938
Vasculitis	91.34	13.03	68	22445	11228	34923190
Muscle twitching	87.79	13.03	64	22449	10234	34924184
Pericarditis	85.11	13.03	66	22447	11579	34922839
Blindness	82.43	13.03	72	22441	14914	34919504
Lip swelling	80.01	13.03	73	22440	16007	34918411
Acute myocardial infarction	78.22	13.03	131	22382	53588	34880830
Transient ischaemic attack	77.11	13.03	92	22421	27521	34906897
Drug ineffective	75.73	13.03	111	22402	456640	34477778
Coronary artery disease	67.94	13.03	116	22397	48189	34886229
Diplopia	67.74	13.03	68	22445	16775	34917643
Angina unstable	66.13	13.03	57	22456	11596	34922822
Tinnitus	64.52	13.03	72	22441	20046	34914372
Rash papular	61.85	13.03	52	22461	10226	34924192
Amnesia	59.06	13.03	79	22434	26484	34907934
Migraine	58.55	13.03	64	22449	17414	34917004
Angina pectoris	53.18	13.03	82	22431	31281	34903137
Dry skin	51.93	13.03	81	22432	31206	34903212
Blood glucose increased	50.53	13.03	124	22389	66594	34867824
Disturbance in attention	49.95	13.03	72	22441	25873	34908545
Alopecia	47.49	13.03	68	22445	24287	34910131
Dizziness	46.37	13.03	269	22244	218252	34716166
Silent myocardial infarction	46.01	13.03	15	22498	391	34934027
Palpitations	45.98	13.03	88	22425	39898	34894520
Angioedema	45.14	13.03	84	22429	37290	34897128
Myocardial ischaemia	43.73	13.03	55	22458	17353	34917065
Cognitive disorder	41.77	13.03	70	22443	28623	34905795
Heart rate increased	40.38	13.03	91	22422	46252	34888166
Hallucination	40.36	13.03	97	22416	51401	34883017
Visual impairment	40.19	13.03	78	22435	35724	34898694
Feeling abnormal	40.13	13.03	110	22403	63125	34871293
Off label use	39.86	13.03	138	22375	419386	34515032
Cardiac failure	37.86	13.03	137	22376	91111	34843307
Drug abuse	37.26	13.03	9	22504	99087	34835331
Toxic epidermal necrolysis	35.85	13.03	56	22457	21590	34912828
Toxicity to various agents	33.72	13.03	48	22465	200314	34734104
Dyspnoea	33.07	13.03	379	22134	376403	34558015
Abdominal discomfort	32.09	13.03	98	22415	59737	34874681
Hyperhidrosis	31.69	13.03	114	22399	75578	34858840
Bradycardia	29.40	13.03	111	22402	75307	34859111
Memory impairment	29.13	13.03	77	22436	43241	34891177
Febrile neutropenia	28.11	13.03	28	22485	136821	34797597
Dehydration	27.50	13.03	160	22353	129809	34804609
Syncope	27.31	13.03	124	22389	91327	34843091
Cutaneous lupus erythematosus	26.73	13.03	12	22501	758	34933660
Hypotension	26.62	13.03	238	22275	221411	34713007
Product use in unapproved indication	26.56	13.03	22	22491	117477	34816941
Coronary artery occlusion	26.52	13.03	34	22479	10928	34923490
Normochromic normocytic anaemia	26.43	13.03	22	22491	4265	34930153
Hypoglycaemia	26.10	13.03	86	22427	54554	34879864
Prinzmetal angina	23.53	13.03	12	22501	1007	34933411
Muscular weakness	23.39	13.03	101	22412	72796	34861622
Neutropenia	23.10	13.03	41	22472	156737	34777681
Bleeding time prolonged	22.04	13.03	10	22503	648	34933770
Completed suicide	21.42	13.03	19	22494	98149	34836269
Malaise	20.01	13.03	195	22318	185630	34748788
Anxiety	19.47	13.03	120	22393	99308	34835110
Intentional product misuse	19.33	13.03	69	22444	45542	34888876
Pulmonary oedema	18.55	13.03	70	22443	47459	34886959
Cerebrovascular accident	18.30	13.03	105	22408	84706	34849712
Drug intolerance	17.84	13.03	8	22505	59562	34874856
Abdominal pain upper	17.78	13.03	92	22421	71398	34863020
Chronic kidney disease	17.17	13.03	62	22451	41148	34893270
Oesophageal ulcer haemorrhage	17.00	13.03	6	22507	200	34934218
Peripheral swelling	16.67	13.03	95	22418	76446	34857972
Arteriospasm coronary	16.13	13.03	15	22498	3367	34931051
Infusion related reaction	16.09	13.03	7	22506	53050	34881368
Malignant neoplasm progression	15.89	13.03	20	22493	88026	34846392
Occult blood positive	15.64	13.03	16	22497	4032	34930386
Myocardial depression	14.87	13.03	4	22509	52	34934366
Pruritus	14.78	13.03	148	22365	141833	34792585
Coronary artery stenosis	14.71	13.03	24	22489	9592	34924826
Renal failure	14.52	13.03	138	22375	130419	34803999
Cardiac failure acute	14.34	13.03	25	22488	10545	34923873
Ischaemia	14.01	13.03	16	22497	4564	34929854
Kounis syndrome	13.64	13.03	12	22501	2506	34931912
Supraventricular tachycardia	13.43	13.03	25	22488	11092	34923326
Therapeutic product effect incomplete	13.34	13.03	8	22505	50533	34883885
Cardiac disorder	13.25	13.03	59	22454	43067	34891351
Insomnia	13.17	13.03	113	22400	103794	34830624
Injury	13.12	13.03	36	22477	20651	34913767

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Myocardial infarction	430.56	12.47	480	37036	183649	79523223
Cardiospasm	364.61	12.47	111	37405	3190	79703682
Palmoplantar keratoderma	347.51	12.47	110	37406	3606	79703266
Sleep terror	323.88	12.47	109	37407	4349	79702523
Cardiac failure congestive	323.67	12.47	366	37150	142036	79564836
Pruritus genital	323.21	12.47	109	37407	4377	79702495
Atrial tachycardia	294.96	12.47	115	37401	7018	79699854
Carotid artery occlusion	287.20	12.47	115	37401	7532	79699340
Tension headache	286.71	12.47	113	37403	7098	79699774
Subarachnoid haemorrhage	262.43	12.47	156	37360	24309	79682563
Anosmia	261.11	12.47	112	37404	8732	79698140
Immunisation	235.62	12.47	72	37444	2095	79704777
Facial pain	231.30	12.47	114	37402	12236	79694636
Pain of skin	204.79	12.47	111	37405	14502	79692370
Ventricular tachycardia	194.89	12.47	160	37356	41775	79665097
Eye pruritus	169.63	12.47	111	37405	20459	79686413
Vasculitis	167.88	12.47	119	37397	24983	79681889
Blindness	165.86	12.47	124	37392	28259	79678613
Transient ischaemic attack	165.26	12.47	161	37355	52534	79654338
Muscle twitching	164.70	12.47	117	37399	24647	79682225
Chest pain	162.73	12.47	389	37127	281915	79424957
Drug ineffective	138.89	12.47	184	37332	1080729	78626143
Acute myocardial infarction	137.05	12.47	175	37341	76861	79630011
Diplopia	133.55	12.47	117	37399	33349	79673523
Lip swelling	126.40	12.47	124	37392	40787	79666085
Coronary artery disease	123.24	12.47	153	37363	65321	79641551
Hallucination	122.39	12.47	175	37341	85570	79621302
Angina unstable	116.67	12.47	81	37435	16446	79690426
Blood glucose increased	114.60	12.47	199	37317	114776	79592096
Tinnitus	112.72	12.47	121	37395	44212	79662660
Disturbance in attention	104.19	12.47	124	37392	50677	79656195
Amnesia	103.97	12.47	138	37378	62919	79643953
Rash papular	102.59	12.47	84	37432	21832	79685040
Dry skin	100.30	12.47	141	37375	67854	79639018
Angioedema	95.28	12.47	146	37370	75889	79630983
Visual impairment	86.02	12.47	155	37361	91976	79614896
Intentional product misuse	84.93	12.47	157	37359	95008	79611864
Angina pectoris	83.41	12.47	112	37404	51620	79655252
Myocardial ischaemia	78.16	12.47	77	37439	25442	79681430
Infusion related reaction	72.28	12.47	11	37505	230226	79476646
Cognitive disorder	72.22	12.47	123	37393	69803	79637069
Bradycardia	70.73	12.47	180	37336	135377	79571495
Treatment failure	67.43	12.47	3	37513	170483	79536389
Cardiac failure	67.11	12.47	192	37324	154650	79552222
Joint swelling	65.34	12.47	27	37489	288619	79418253
Dehydration	65.18	12.47	260	37256	247927	79458945
Hyperhidrosis	64.84	12.47	187	37329	151305	79555567
Palpitations	62.83	12.47	165	37351	126445	79580427
Silent myocardial infarction	61.53	12.47	20	37496	714	79706158
Heart rate increased	58.55	12.47	156	37360	120568	79586304
Drug intolerance	56.17	12.47	27	37489	264092	79442780
Arthropathy	54.37	12.47	9	37507	177102	79529770
Migraine	54.00	12.47	124	37392	87369	79619503
Nasopharyngitis	50.93	12.47	28	37488	253853	79453019
Dizziness	49.90	12.47	420	37096	526021	79180851
Off label use	46.26	12.47	245	37271	906970	78799902
Therapeutic product effect decreased	44.73	12.47	11	37505	163852	79543020
Feeling abnormal	44.37	12.47	170	37346	159029	79547843
Toxic epidermal necrolysis	44.16	12.47	77	37439	44504	79662368
Muscular weakness	43.46	12.47	170	37346	160559	79546313
Swelling	43.32	12.47	24	37492	216687	79490185
Syncope	42.36	12.47	182	37334	179267	79527605
Rheumatoid arthritis	41.80	12.47	23	37493	208447	79498425
Generalised bullous fixed drug eruption	41.75	12.47	11	37505	184	79706688
Memory impairment	40.36	12.47	130	37386	111604	79595268
Hepatic enzyme increased	39.84	12.47	18	37498	182592	79524280
Cerebrovascular accident	39.38	12.47	161	37355	155131	79551741
Renal failure	38.69	12.47	192	37324	200776	79506096
Contraindicated product administered	38.54	12.47	13	37503	157525	79549347
Arteriospasm coronary	38.46	12.47	29	37487	6687	79700185
Dyspnoea	38.28	12.47	590	36926	856435	78850437
Product use issue	38.10	12.47	26	37490	209796	79497076
Maternal exposure during pregnancy	37.59	12.47	9	37507	136529	79570343
Systemic lupus erythematosus	37.52	12.47	6	37510	121143	79585729
Coronary artery occlusion	35.78	12.47	40	37476	15275	79691597
Febrile neutropenia	32.97	12.47	36	37480	230963	79475909
Lower respiratory tract infection	32.78	12.47	10	37506	129210	79577662
Neutropenia	32.75	12.47	53	37463	287657	79419215
Prinzmetal angina	32.56	12.47	16	37500	1704	79705168
Product use in unapproved indication	32.55	12.47	42	37474	250317	79456555
Pericarditis	32.12	12.47	115	37401	104121	79602751
Hypotension	31.96	12.47	332	37184	439985	79266887
Tachycardia	30.84	12.47	165	37351	177603	79529269
Hypoglycaemia	30.38	12.47	111	37405	101483	79605389
Glossodynia	30.09	12.47	6	37510	103331	79603541
Anxiety	30.02	12.47	210	37306	248302	79458570
Drug abuse	29.74	12.47	20	37496	162671	79544201
Acute coronary syndrome	28.47	12.47	42	37474	21091	79685781
Infection	28.00	12.47	44	37472	241668	79465204
Hypersensitivity	27.39	12.47	51	37465	262188	79444684
Ischaemic cardiomyopathy	26.94	12.47	25	37491	7670	79699202
Coronary artery stenosis	26.45	12.47	31	37485	12453	79694419
Therapeutic product effect incomplete	25.11	12.47	18	37498	141627	79565245
Discomfort	24.96	12.47	14	37502	125603	79581269
Normochromic normocytic anaemia	24.94	12.47	24	37492	7703	79699169
Toxicity to various agents	24.18	12.47	109	37407	421431	79285441
Insomnia	23.89	12.47	197	37319	244973	79461899
Rhabdomyolysis	23.85	12.47	104	37412	103027	79603845
Drug interaction	23.35	12.47	298	37218	414885	79291987
Sinusitis	23.20	12.47	35	37481	195466	79511406
Weight increased	23.17	12.47	61	37455	277325	79429547
Chronic kidney disease	23.00	12.47	76	37440	66078	79640794
Gastrointestinal haemorrhage	22.88	12.47	133	37383	147586	79559286
COVID-19	21.90	12.47	138	37378	157536	79549336
Condition aggravated	21.88	12.47	142	37374	500982	79205890
Coronary arterial stent insertion	21.86	12.47	20	37496	6024	79700848
Cardiac failure acute	21.82	12.47	35	37481	18894	79687978
Psoriatic arthropathy	21.74	12.47	5	37511	77994	79628878
Bleeding time prolonged	21.55	12.47	11	37505	1270	79705602
Electrocardiogram ST segment elevation	21.47	12.47	23	37493	8374	79698498
Cardiac disorder	20.63	12.47	73	37443	65684	79641188
Ischaemia	20.44	12.47	22	37494	8053	79698819
Helicobacter infection	20.39	12.47	4	37512	69700	79637172
Abdominal pain upper	20.29	12.47	177	37339	223642	79483230
Wound	20.28	12.47	15	37501	116164	79590708
Musculoskeletal stiffness	20.13	12.47	32	37484	174976	79531896
International normalised ratio increased	20.02	12.47	86	37430	84635	79622237
Cutaneous lupus erythematosus	19.52	12.47	14	37502	2989	79703883
Drug hypersensitivity	19.17	12.47	74	37442	298842	79408030
Neuropathy peripheral	19.09	12.47	23	37493	141282	79565590
Pulmonary oedema	18.91	12.47	87	37429	88167	79618705
Atrial fibrillation	18.20	12.47	157	37359	197729	79509143
Red cell distribution width abnormal	18.13	12.47	6	37510	227	79706645
Haemorrhagic diathesis	17.96	12.47	18	37498	6066	79700806
Blood urea increased	17.82	12.47	57	37459	48733	79658139
Exposure during pregnancy	17.73	12.47	13	37503	101119	79605753
Hyperkalaemia	17.71	12.47	103	37413	114295	79592577
Blood pressure decreased	17.70	12.47	93	37423	99373	79607499
Mesenteric arterial occlusion	17.64	12.47	6	37510	247	79706625
General physical health deterioration	17.10	12.47	69	37447	275169	79431703
Back pain	16.52	12.47	217	37299	303963	79402909
Anhedonia	16.43	12.47	27	37489	14871	79692001
Fibromyalgia	16.27	12.47	5	37511	64335	79642537
Cardiac failure chronic	16.27	12.47	23	37493	11112	79695760
Flushing	15.93	12.47	11	37505	88257	79618615
Impaired healing	15.71	12.47	11	37505	87644	79619228
Injection site pain	15.64	12.47	23	37493	129815	79577057
Fear	15.64	12.47	33	37483	21953	79684919
Peripheral vascular disorder	15.47	12.47	19	37497	8011	79698861
Arthritis	15.20	12.47	19	37497	114861	79592011
Sedation	15.13	12.47	3	37513	51892	79654980
Renal hypoplasia	14.97	12.47	3	37513	13	79706859
Delirium	14.97	12.47	79	37437	84548	79622324
Pulseless electrical activity	14.73	12.47	25	37491	14135	79692737
Left ventricular hypertrophy	14.73	12.47	22	37494	11169	79695703
Occult blood positive	14.43	12.47	17	37499	6866	79700006
Atrioventricular block complete	14.30	12.47	27	37489	16583	79690289
Blood creatinine increased	14.24	12.47	123	37393	154934	79551938
Mucosal inflammation	14.20	12.47	9	37507	75571	79631301
Stomatitis	14.06	12.47	30	37486	146727	79560145
Dysphoria	13.97	12.47	14	37502	4720	79702152
Rash	13.95	12.47	190	37326	578168	79128704
Muscle injury	13.76	12.47	3	37513	48558	79658314
Hepatic function abnormal	13.45	12.47	69	37447	73038	79633834
Renal impairment	13.38	12.47	123	37393	157660	79549212
Inappropriate schedule of product administration	13.06	12.47	27	37489	133601	79573271
Pruritus	12.96	12.47	259	37257	394389	79312483
Inflammation	12.94	12.47	15	37501	93738	79613134
Ephelides	12.91	12.47	4	37512	122	79706750
Sinus node dysfunction	12.91	12.47	17	37499	7684	79699188
Leukopenia	12.74	12.47	22	37494	116491	79590381
Acute kidney injury	12.71	12.47	327	37189	519077	79187795
Red blood cell sedimentation rate increased	12.69	12.47	3	37513	45939	79660933
Sinus bradycardia	12.61	12.47	33	37483	25214	79681658
Injection site reaction	12.58	12.47	5	37511	54780	79652092
Gamma-glutamyltransferase abnormal	12.57	12.47	6	37510	600	79706272
Oropharyngeal pain	12.56	12.47	20	37496	109333	79597539
Oesophageal ulcer haemorrhage	12.48	12.47	6	37510	609	79706263

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C01DA08	CARDIOVASCULAR SYSTEM CARDIAC THERAPY VASODILATORS USED IN CARDIAC DISEASES Organic nitrates
ATC	C01DA58	CARDIOVASCULAR SYSTEM CARDIAC THERAPY VASODILATORS USED IN CARDIAC DISEASES Organic nitrates
ATC	C05AE02	CARDIOVASCULAR SYSTEM VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Muscle relaxants
FDA CS	M0014874	Nitrates
FDA PE	N0000009909	Vasodilation
FDA EPC	N0000175415	Nitrate Vasodilator
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D020030	Nitric Oxide Donors
MeSH PA	D014665	Vasodilator Agents
CHEBI has role	CHEBI:35620	vasodilator agents
CHEBI has role	CHEBI:50566	nitric oxide generators

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Chronic heart failure	indication	48447003
Angina pectoris	indication	194828000
Angina Pectoris Prevention	indication
Prevention of Bleeding Esophageal Varices	off-label use
Myocardial infarction	contraindication	22298006	DOID:5844
Hypovolemia	contraindication	28560003
Hyperthyroidism	contraindication	34486009	DOID:7998
Low blood pressure	contraindication	45007003
Benign intracranial hypertension	contraindication	68267002	DOID:11459
Injury of head	contraindication	82271004
Increased intestinal motility	contraindication	102624003
Cerebrovascular accident	contraindication	230690007
Hypertrophic cardiomyopathy	contraindication	233873004	DOID:11984
Lupus erythematosus and erythema multiforme-like syndrome	contraindication	238926009
Anemia	contraindication	271737000	DOID:2355
Cerebral hemorrhage	contraindication	274100004
Disorder of coronary artery	contraindication	414024009
Myocardial infarction in recovery phase	contraindication	418044006
Slow acetylator due to N-acetyltransferase enzyme variant	contraindication	425079005
Malabsorption States	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Soluble guanylate cyclase	Enzyme	O75343 P33402 Q02108 Q02153	GCYB2_HUMAN GCYA2_HUMAN GCYA3_HUMAN GCYB1_HUMAN	ACTIVATOR				CHEMBL	CHEMBL
Atrial natriuretic peptide receptor 1	Enzyme	P16066	ANPRA_HUMAN					WOMBAT-PK

External reference:

ID	Source
4017825	VUID
N0000146183	NUI
D00516	KEGG_DRUG
4017825	VANDF
C0022252	UMLSCUI
CHEBI:6061	CHEBI
CHEMBL6622	ChEMBL_ID
D007548	MESH_DESCRIPTOR_UI
DB00883	DRUGBANK_ID
7051	IUPHAR_LIGAND_ID
996	INN_ID
IA7306519N	UNII
6883	PUBCHEM_CID
379630	RXNORM
2988	MMSL
2996	MMSL
4934	MMSL
d00268	MMSL
000688	NDDF
387332007	SNOMEDCT_US
5924003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0143-1765	TABLET	2.50 mg	SUBLINGUAL	ANDA	21 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0143-1767	TABLET	5 mg	SUBLINGUAL	ANDA	21 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0143-1769	TABLET	5 mg	ORAL	ANDA	21 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0143-1769	TABLET	5 mg	ORAL	ANDA	21 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0143-1771	TABLET	10 mg	ORAL	ANDA	21 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0143-1771	TABLET	10 mg	ORAL	ANDA	21 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0143-1772	TABLET	20 mg	ORAL	ANDA	21 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0143-1772	TABLET	20 mg	ORAL	ANDA	21 sections
IsordilTitradose	HUMAN PRESCRIPTION DRUG LABEL	1	0187-0152	TABLET	5 mg	ORAL	NDA	20 sections
IsordilTitradose	HUMAN PRESCRIPTION DRUG LABEL	1	0187-0192	TABLET	40 mg	ORAL	NDA	20 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-1560	TABLET	10 mg	ORAL	ANDA	21 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-1575	TABLET	20 mg	ORAL	ANDA	21 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8157	TABLET	10 mg	ORAL	ANDA	21 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8157	TABLET	10 mg	ORAL	ANDA	21 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8193	TABLET	30 mg	ORAL	ANDA	21 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8193	TABLET	30 mg	ORAL	ANDA	21 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8294	TABLET	20 mg	ORAL	ANDA	21 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8294	TABLET	20 mg	ORAL	ANDA	21 sections
ISOSORBIDE DINITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8463	TABLET	10 mg	ORAL	ANDA	21 sections
ISOSORBIDE DINITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8464	TABLET	20 mg	ORAL	ANDA	21 sections
ISOSORBIDE DINITRATE	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8465	TABLET	30 mg	ORAL	ANDA	21 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0781-1556	TABLET	10 mg	ORAL	ANDA	23 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0781-1556	TABLET	10 mg	ORAL	ANDA	23 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0781-1635	TABLET	5 mg	ORAL	ANDA	23 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0781-1635	TABLET	5 mg	ORAL	ANDA	23 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0781-1695	TABLET	20 mg	ORAL	ANDA	23 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0781-1695	TABLET	20 mg	ORAL	ANDA	23 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6619	TABLET	10 mg	ORAL	ANDA	21 sections
Isosorbide Dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6620	TABLET	20 mg	ORAL	ANDA	21 sections
Isosorbide dinitrate	HUMAN PRESCRIPTION DRUG LABEL	1	16714-007	TABLET	5 mg	ORAL	ANDA	17 sections