Stem definition | Drug id | CAS RN |
---|---|---|
2717 | 19794-93-5 |
Dose | Unit | Route |
---|---|---|
0.30 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.20 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 23.05 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 81 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.52 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 1.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.08 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 7.30 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 24, 1981 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1082.36 | 10.20 | 1309 | 97511 | 130580 | 50375724 |
Drug abuse | 451.14 | 10.20 | 570 | 98250 | 59276 | 50447028 |
Sopor | 377.43 | 10.20 | 312 | 98508 | 19567 | 50486737 |
Toxicity to various agents | 370.27 | 10.20 | 1080 | 97740 | 211419 | 50294885 |
Serotonin syndrome | 355.02 | 10.20 | 331 | 98489 | 24382 | 50481922 |
Hand deformity | 172.52 | 10.20 | 5 | 98815 | 100194 | 50406110 |
Systemic lupus erythematosus | 157.82 | 10.20 | 40 | 98780 | 140582 | 50365722 |
Suicide attempt | 154.87 | 10.20 | 324 | 98496 | 51408 | 50454896 |
Polycystic ovaries | 143.53 | 10.20 | 78 | 98742 | 2406 | 50503898 |
Suicidal ideation | 143.19 | 10.20 | 327 | 98493 | 55058 | 50451246 |
Cardio-respiratory arrest | 141.34 | 10.20 | 320 | 98500 | 53572 | 50452732 |
Maternal exposure during pregnancy | 139.19 | 10.20 | 69 | 98751 | 159709 | 50346595 |
Pericarditis | 131.65 | 10.20 | 5 | 98815 | 78684 | 50427620 |
Swelling | 130.50 | 10.20 | 120 | 98700 | 200752 | 50305552 |
Synovitis | 121.40 | 10.20 | 45 | 98775 | 123820 | 50382484 |
Presbyacusis | 117.09 | 10.20 | 71 | 98749 | 2705 | 50503599 |
Wound | 116.95 | 10.20 | 31 | 98789 | 105763 | 50400541 |
Glossodynia | 116.65 | 10.20 | 40 | 98780 | 115529 | 50390775 |
Hypomania | 114.36 | 10.20 | 84 | 98736 | 4421 | 50501883 |
Overdose | 108.83 | 10.20 | 434 | 98386 | 99293 | 50407011 |
Pleural thickening | 105.84 | 10.20 | 65 | 98755 | 2534 | 50503770 |
Pleural fibrosis | 104.21 | 10.20 | 71 | 98749 | 3313 | 50502991 |
Sensitisation | 103.60 | 10.20 | 54 | 98766 | 1528 | 50504776 |
Drug interaction | 103.05 | 10.20 | 705 | 98115 | 198916 | 50307388 |
Exposure during pregnancy | 101.30 | 10.20 | 55 | 98765 | 120960 | 50385344 |
Infusion related reaction | 101.25 | 10.20 | 109 | 98711 | 169448 | 50336856 |
Blood magnesium increased | 99.72 | 10.20 | 65 | 98755 | 2815 | 50503489 |
Schizophrenia | 98.42 | 10.20 | 95 | 98725 | 7302 | 50499002 |
Joint swelling | 97.03 | 10.20 | 209 | 98611 | 245077 | 50261227 |
Depression | 96.80 | 10.20 | 603 | 98217 | 164820 | 50341484 |
Product dose omission issue | 95.91 | 10.20 | 651 | 98169 | 183187 | 50323117 |
Contraindicated product administered | 95.51 | 10.20 | 90 | 98730 | 148868 | 50357436 |
Electrocardiogram QT prolonged | 95.12 | 10.20 | 269 | 98551 | 51617 | 50454687 |
Anxiety | 93.28 | 10.20 | 630 | 98190 | 176976 | 50329328 |
Migraine | 91.44 | 10.20 | 339 | 98481 | 74941 | 50431363 |
Withdrawal syndrome | 88.32 | 10.20 | 138 | 98682 | 17452 | 50488852 |
Deafness neurosensory | 86.14 | 10.20 | 71 | 98749 | 4430 | 50501874 |
Ejection fraction | 84.47 | 10.20 | 43 | 98777 | 1157 | 50505147 |
Jaundice cholestatic | 78.30 | 10.20 | 71 | 98749 | 5040 | 50501264 |
Rash | 78.21 | 10.20 | 517 | 98303 | 436954 | 50069350 |
Alopecia | 73.20 | 10.20 | 240 | 98580 | 244807 | 50261497 |
Sleep apnoea syndrome | 73.16 | 10.20 | 151 | 98669 | 23717 | 50482587 |
Abdominal discomfort | 72.60 | 10.20 | 222 | 98598 | 231419 | 50274885 |
Helicobacter infection | 71.69 | 10.20 | 7 | 98813 | 49695 | 50456609 |
Arthropathy | 70.66 | 10.20 | 125 | 98695 | 157781 | 50348523 |
Neutropenia | 70.01 | 10.20 | 113 | 98707 | 147852 | 50358452 |
Epigastric discomfort | 69.96 | 10.20 | 71 | 98749 | 5799 | 50500505 |
Memory impairment | 67.86 | 10.20 | 321 | 98499 | 79039 | 50427265 |
Blood test abnormal | 67.12 | 10.20 | 96 | 98724 | 11223 | 50495081 |
Gastrooesophageal reflux disease | 65.25 | 10.20 | 309 | 98511 | 76119 | 50430185 |
Suspected suicide | 64.21 | 10.20 | 65 | 98755 | 5292 | 50501012 |
Folliculitis | 63.91 | 10.20 | 3 | 98817 | 39222 | 50467082 |
Myocardial stunning | 63.62 | 10.20 | 20 | 98800 | 139 | 50506165 |
Irritability | 62.84 | 10.20 | 158 | 98662 | 28268 | 50478036 |
Impaired healing | 62.46 | 10.20 | 29 | 98791 | 69757 | 50436547 |
Confabulation | 62.30 | 10.20 | 23 | 98797 | 273 | 50506031 |
Rhinitis allergic | 61.32 | 10.20 | 73 | 98747 | 7127 | 50499177 |
Insomnia | 59.23 | 10.20 | 561 | 98259 | 174304 | 50332000 |
Neovascularisation | 59.06 | 10.20 | 32 | 98788 | 981 | 50505323 |
Sleep disorder due to a general medical condition | 56.72 | 10.20 | 71 | 98749 | 7300 | 50499004 |
Drug intolerance | 55.92 | 10.20 | 229 | 98591 | 218875 | 50287429 |
Thrombocytopenia | 55.37 | 10.20 | 103 | 98717 | 127570 | 50378734 |
Psychotic disorder | 54.38 | 10.20 | 127 | 98693 | 21685 | 50484619 |
Muscle injury | 54.12 | 10.20 | 5 | 98815 | 37106 | 50469198 |
Hyper IgE syndrome | 53.77 | 10.20 | 23 | 98797 | 411 | 50505893 |
Asphyxia | 52.91 | 10.20 | 59 | 98761 | 5368 | 50500936 |
Anaemia | 52.58 | 10.20 | 284 | 98536 | 252172 | 50254132 |
Bone cyst | 51.96 | 10.20 | 38 | 98782 | 1986 | 50504318 |
General physical health deterioration | 51.70 | 10.20 | 127 | 98693 | 142307 | 50363997 |
Haemoglobin decreased | 51.40 | 10.20 | 107 | 98713 | 127109 | 50379195 |
Agitation | 50.89 | 10.20 | 223 | 98597 | 53161 | 50453143 |
Tremor | 50.67 | 10.20 | 391 | 98429 | 114512 | 50391792 |
Lung diffusion test abnormal | 50.34 | 10.20 | 17 | 98803 | 152 | 50506152 |
Respiratory arrest | 49.63 | 10.20 | 150 | 98670 | 29859 | 50476445 |
Pyrexia | 49.15 | 10.20 | 490 | 98330 | 379713 | 50126591 |
Rheumatoid factor positive | 49.01 | 10.20 | 18 | 98802 | 49841 | 50456463 |
Skin lesion | 48.41 | 10.20 | 138 | 98682 | 26589 | 50479715 |
Pancytopenia | 47.95 | 10.20 | 56 | 98764 | 83974 | 50422330 |
Febrile neutropenia | 47.69 | 10.20 | 73 | 98747 | 97594 | 50408710 |
Nightmare | 47.23 | 10.20 | 100 | 98720 | 15986 | 50490318 |
Hyperreflexia | 47.10 | 10.20 | 54 | 98766 | 5064 | 50501240 |
Paradoxical drug reaction | 46.94 | 10.20 | 46 | 98774 | 3601 | 50502703 |
Hypersensitivity | 46.49 | 10.20 | 239 | 98581 | 214922 | 50291382 |
Arteriosclerosis coronary artery | 45.62 | 10.20 | 65 | 98755 | 7571 | 50498733 |
Visual perseveration | 45.47 | 10.20 | 13 | 98807 | 62 | 50506242 |
Extrapyramidal disorder | 45.30 | 10.20 | 82 | 98738 | 11688 | 50494616 |
Cyst | 44.50 | 10.20 | 83 | 98737 | 12104 | 50494200 |
Accidental poisoning | 43.62 | 10.20 | 22 | 98798 | 580 | 50505724 |
Oral discomfort | 43.20 | 10.20 | 65 | 98755 | 7952 | 50498352 |
Leukopenia | 43.01 | 10.20 | 41 | 98779 | 67487 | 50438817 |
Malignant neoplasm progression | 42.65 | 10.20 | 42 | 98778 | 68082 | 50438222 |
Therapeutic product effect decreased | 42.14 | 10.20 | 131 | 98689 | 135919 | 50370385 |
Intentional overdose | 41.73 | 10.20 | 236 | 98584 | 62268 | 50444036 |
Carpal tunnel syndrome | 41.71 | 10.20 | 98 | 98722 | 16795 | 50489509 |
Mucosal inflammation | 40.29 | 10.20 | 14 | 98806 | 40128 | 50466176 |
Persistent genital arousal disorder | 40.20 | 10.20 | 16 | 98804 | 236 | 50506068 |
Nephrectomy | 39.50 | 10.20 | 23 | 98797 | 812 | 50505492 |
Adjustment disorder with mixed anxiety and depressed mood | 39.40 | 10.20 | 12 | 98808 | 74 | 50506230 |
Fall | 39.11 | 10.20 | 892 | 97928 | 334040 | 50172264 |
Lower respiratory tract infection | 38.51 | 10.20 | 80 | 98740 | 95121 | 50411183 |
Drug withdrawal syndrome | 38.35 | 10.20 | 122 | 98698 | 24959 | 50481345 |
Sleep disorder | 38.05 | 10.20 | 216 | 98604 | 57067 | 50449237 |
Osteopenia | 38.04 | 10.20 | 95 | 98725 | 16923 | 50489381 |
Injection site mass | 37.67 | 10.20 | 90 | 98730 | 15590 | 50490714 |
Discomfort | 37.49 | 10.20 | 99 | 98721 | 108281 | 50398023 |
C-reactive protein abnormal | 37.39 | 10.20 | 5 | 98815 | 27804 | 50478500 |
Stomatitis | 37.04 | 10.20 | 90 | 98730 | 101254 | 50405050 |
Fibromyalgia | 36.32 | 10.20 | 179 | 98641 | 44799 | 50461505 |
Somatic delusion | 36.15 | 10.20 | 19 | 98801 | 547 | 50505757 |
Blister | 36.07 | 10.20 | 70 | 98750 | 85348 | 50420956 |
Intentional self-injury | 35.87 | 10.20 | 113 | 98707 | 22999 | 50483305 |
Poor quality sleep | 35.20 | 10.20 | 91 | 98729 | 16555 | 50489749 |
Bone marrow failure | 34.78 | 10.20 | 6 | 98814 | 27618 | 50478686 |
Bradyphrenia | 34.76 | 10.20 | 51 | 98769 | 6101 | 50500203 |
Osteosclerosis | 34.33 | 10.20 | 38 | 98782 | 3429 | 50502875 |
Abnormal behaviour | 34.15 | 10.20 | 100 | 98720 | 19558 | 50486746 |
Blood potassium increased | 34.02 | 10.20 | 89 | 98731 | 16309 | 50489995 |
Hostility | 33.87 | 10.20 | 28 | 98792 | 1754 | 50504550 |
Encephalopathy | 33.80 | 10.20 | 143 | 98677 | 33568 | 50472736 |
Dry eye | 33.63 | 10.20 | 138 | 98682 | 31957 | 50474347 |
Muscle rigidity | 33.49 | 10.20 | 65 | 98755 | 9764 | 50496540 |
Psoriasis | 33.35 | 10.20 | 240 | 98580 | 68760 | 50437544 |
Multiple sclerosis relapse | 33.28 | 10.20 | 169 | 98651 | 42795 | 50463509 |
Asthma | 32.93 | 10.20 | 292 | 98528 | 89045 | 50417259 |
Pleurothotonus | 32.44 | 10.20 | 24 | 98796 | 1277 | 50505027 |
Listless | 32.37 | 10.20 | 31 | 98789 | 2359 | 50503945 |
Loss of personal independence in daily activities | 32.33 | 10.20 | 241 | 98579 | 69809 | 50436495 |
Sputum discoloured | 32.31 | 10.20 | 77 | 98743 | 13318 | 50492986 |
Blepharospasm | 32.14 | 10.20 | 34 | 98786 | 2914 | 50503390 |
Depressed level of consciousness | 31.97 | 10.20 | 192 | 98628 | 51761 | 50454543 |
Alcoholism | 31.93 | 10.20 | 26 | 98794 | 1594 | 50504710 |
Akathisia | 31.25 | 10.20 | 57 | 98763 | 8172 | 50498132 |
Hereditary angioedema | 30.58 | 10.20 | 45 | 98775 | 5397 | 50500907 |
Ill-defined disorder | 30.56 | 10.20 | 37 | 98783 | 54617 | 50451687 |
Restrictive pulmonary disease | 30.51 | 10.20 | 24 | 98796 | 1400 | 50504904 |
Vertigo | 29.66 | 10.20 | 188 | 98632 | 51644 | 50454660 |
Rheumatoid arthritis | 29.58 | 10.20 | 253 | 98567 | 202297 | 50304007 |
Somnolence | 29.30 | 10.20 | 445 | 98375 | 154540 | 50351764 |
Disorganised speech | 28.65 | 10.20 | 20 | 98800 | 971 | 50505333 |
Muscle twitching | 28.26 | 10.20 | 80 | 98740 | 15351 | 50490953 |
Sleep disorder due to general medical condition, insomnia type | 28.24 | 10.20 | 13 | 98807 | 31434 | 50474870 |
Cardiac failure | 28.20 | 10.20 | 67 | 98753 | 75973 | 50430331 |
Platelet count decreased | 27.76 | 10.20 | 102 | 98718 | 100624 | 50405680 |
Sedation | 27.76 | 10.20 | 126 | 98694 | 30484 | 50475820 |
Cardiac failure congestive | 27.74 | 10.20 | 79 | 98741 | 84303 | 50422001 |
Sternal fracture | 27.17 | 10.20 | 26 | 98794 | 1976 | 50504328 |
Cholestasis | 27.01 | 10.20 | 8 | 98812 | 25393 | 50480911 |
Hyperhidrosis | 26.88 | 10.20 | 280 | 98540 | 89146 | 50417158 |
Libido increased | 26.74 | 10.20 | 21 | 98799 | 1222 | 50505082 |
Mental disorder | 26.65 | 10.20 | 99 | 98721 | 21892 | 50484412 |
Cognitive disorder | 26.47 | 10.20 | 162 | 98658 | 43961 | 50462343 |
Treatment failure | 26.37 | 10.20 | 159 | 98661 | 137478 | 50368826 |
Middle insomnia | 26.09 | 10.20 | 59 | 98761 | 9862 | 50496442 |
Sensation of foreign body | 25.75 | 10.20 | 35 | 98785 | 3901 | 50502403 |
Cardiac arrest | 25.66 | 10.20 | 263 | 98557 | 83388 | 50422916 |
Restless legs syndrome | 24.92 | 10.20 | 78 | 98742 | 15819 | 50490485 |
Tonic clonic movements | 24.69 | 10.20 | 20 | 98800 | 1217 | 50505087 |
Psychomotor hyperactivity | 24.11 | 10.20 | 55 | 98765 | 9246 | 50497058 |
Intentional product misuse | 24.01 | 10.20 | 165 | 98655 | 46569 | 50459735 |
Apallic syndrome | 23.68 | 10.20 | 15 | 98805 | 618 | 50505686 |
Compartment syndrome | 23.67 | 10.20 | 24 | 98796 | 1958 | 50504346 |
Soft tissue injury | 23.49 | 10.20 | 21 | 98799 | 1463 | 50504841 |
Torsade de pointes | 23.30 | 10.20 | 63 | 98757 | 11772 | 50494532 |
Gambling disorder | 23.19 | 10.20 | 19 | 98801 | 1175 | 50505129 |
Acute kidney injury | 23.13 | 10.20 | 310 | 98510 | 227748 | 50278556 |
Sinus bradycardia | 22.84 | 10.20 | 67 | 98753 | 13116 | 50493188 |
Major depression | 22.82 | 10.20 | 45 | 98775 | 6839 | 50499465 |
Sense of a foreshortened future | 22.75 | 10.20 | 5 | 98815 | 5 | 50506299 |
Irritable bowel syndrome | 22.73 | 10.20 | 41 | 98779 | 51400 | 50454904 |
Post-traumatic neck syndrome | 22.57 | 10.20 | 23 | 98797 | 1887 | 50504417 |
Cytomegalovirus infection | 22.40 | 10.20 | 4 | 98816 | 17958 | 50488346 |
Solar urticaria | 22.22 | 10.20 | 7 | 98813 | 49 | 50506255 |
Vasoplegia syndrome | 22.21 | 10.20 | 18 | 98802 | 1096 | 50505208 |
Mood altered | 22.21 | 10.20 | 65 | 98755 | 12708 | 50493596 |
Exostosis | 21.91 | 10.20 | 61 | 98759 | 11592 | 50494712 |
Meningitis streptococcal | 21.89 | 10.20 | 9 | 98811 | 145 | 50506159 |
Dyskinesia | 21.86 | 10.20 | 110 | 98710 | 27751 | 50478553 |
Mental status changes | 21.65 | 10.20 | 133 | 98687 | 36139 | 50470165 |
Toxic epidermal necrolysis | 21.63 | 10.20 | 7 | 98813 | 20985 | 50485319 |
Body tinea | 21.45 | 10.20 | 19 | 98801 | 1308 | 50504996 |
Clonus | 21.30 | 10.20 | 33 | 98787 | 4142 | 50502162 |
Periorbital swelling | 21.09 | 10.20 | 22 | 98798 | 1855 | 50504449 |
Tardive dyskinesia | 21.08 | 10.20 | 45 | 98775 | 7234 | 50499070 |
Coma | 21.00 | 10.20 | 186 | 98634 | 56693 | 50449611 |
Disease progression | 20.95 | 10.20 | 106 | 98714 | 95760 | 50410544 |
Product use issue | 20.80 | 10.20 | 189 | 98631 | 149286 | 50357018 |
Unresponsive to stimuli | 20.70 | 10.20 | 116 | 98704 | 30493 | 50475811 |
Abortion spontaneous | 20.59 | 10.20 | 31 | 98789 | 41741 | 50464563 |
Abnormal dreams | 20.59 | 10.20 | 52 | 98768 | 9325 | 50496979 |
Post-traumatic stress disorder | 20.55 | 10.20 | 33 | 98787 | 4270 | 50502034 |
Infantile vomiting | 20.41 | 10.20 | 8 | 98812 | 113 | 50506191 |
Reduced facial expression | 20.32 | 10.20 | 20 | 98800 | 1574 | 50504730 |
Alanine aminotransferase increased | 20.29 | 10.20 | 96 | 98724 | 88263 | 50418041 |
Perseveration | 20.20 | 10.20 | 10 | 98810 | 253 | 50506051 |
Initial insomnia | 20.15 | 10.20 | 36 | 98784 | 5079 | 50501225 |
Peripheral swelling | 20.14 | 10.20 | 282 | 98538 | 205654 | 50300650 |
Autonomic nervous system imbalance | 20.01 | 10.20 | 24 | 98796 | 2361 | 50503943 |
Liver function test abnormal | 19.90 | 10.20 | 35 | 98785 | 44304 | 50462000 |
Affect lability | 19.87 | 10.20 | 50 | 98770 | 8948 | 50497356 |
Accommodation disorder | 19.82 | 10.20 | 11 | 98809 | 354 | 50505950 |
Drug ineffective for unapproved indication | 19.59 | 10.20 | 88 | 98732 | 21193 | 50485111 |
Heart rate abnormal | 19.59 | 10.20 | 31 | 98789 | 3961 | 50502343 |
Premature delivery | 19.43 | 10.20 | 11 | 98809 | 23652 | 50482652 |
Dysphoria | 19.32 | 10.20 | 34 | 98786 | 4740 | 50501564 |
Oppositional defiant disorder | 19.30 | 10.20 | 6 | 98814 | 40 | 50506264 |
Hospitalisation | 19.14 | 10.20 | 210 | 98610 | 67727 | 50438577 |
Dissociation | 19.13 | 10.20 | 23 | 98797 | 2268 | 50504036 |
Head discomfort | 19.09 | 10.20 | 56 | 98764 | 10963 | 50495341 |
Purple glove syndrome | 19.09 | 10.20 | 9 | 98811 | 204 | 50506100 |
Anger | 19.06 | 10.20 | 57 | 98763 | 11276 | 50495028 |
Headache | 18.97 | 10.20 | 1188 | 97632 | 505347 | 50000957 |
Multiple organ dysfunction syndrome | 18.94 | 10.20 | 44 | 98776 | 50293 | 50456011 |
Accidental death | 18.81 | 10.20 | 20 | 98800 | 1724 | 50504580 |
Skin texture abnormal | 18.75 | 10.20 | 11 | 98809 | 394 | 50505910 |
Tachyphrenia | 18.49 | 10.20 | 17 | 98803 | 1228 | 50505076 |
Renal failure | 18.47 | 10.20 | 127 | 98693 | 106506 | 50399798 |
Hepatic function abnormal | 18.40 | 10.20 | 22 | 98798 | 32659 | 50473645 |
Burning mouth syndrome | 18.31 | 10.20 | 11 | 98809 | 412 | 50505892 |
Slow speech | 18.07 | 10.20 | 17 | 98803 | 1265 | 50505039 |
Burning sensation | 18.02 | 10.20 | 151 | 98669 | 45295 | 50461009 |
Total lung capacity decreased | 17.97 | 10.20 | 17 | 98803 | 1274 | 50505030 |
Haemangioma congenital | 17.93 | 10.20 | 11 | 98809 | 428 | 50505876 |
Hepatic failure | 17.89 | 10.20 | 22 | 98798 | 32261 | 50474043 |
C-reactive protein increased | 17.86 | 10.20 | 68 | 98752 | 66406 | 50439898 |
Septic shock | 17.72 | 10.20 | 55 | 98765 | 57120 | 50449184 |
Product physical issue | 17.72 | 10.20 | 31 | 98789 | 4301 | 50502003 |
Psychomotor skills impaired | 17.70 | 10.20 | 21 | 98799 | 2043 | 50504261 |
Hip arthroplasty | 17.65 | 10.20 | 20 | 98800 | 30409 | 50475895 |
Therapy interrupted | 17.56 | 10.20 | 82 | 98738 | 20070 | 50486234 |
Ejection fraction abnormal | 17.56 | 10.20 | 14 | 98806 | 833 | 50505471 |
Substance abuse | 17.51 | 10.20 | 30 | 98790 | 4094 | 50502210 |
Drug screen positive | 17.51 | 10.20 | 27 | 98793 | 3375 | 50502929 |
Concussion | 17.49 | 10.20 | 43 | 98777 | 7585 | 50498719 |
Myoclonus | 17.41 | 10.20 | 65 | 98755 | 14405 | 50491899 |
Premature baby | 17.39 | 10.20 | 7 | 98813 | 18330 | 50487974 |
Haematocrit decreased | 17.20 | 10.20 | 26 | 98794 | 34950 | 50471354 |
Bradycardia | 17.18 | 10.20 | 197 | 98623 | 64229 | 50442075 |
Disseminated intravascular coagulation | 17.15 | 10.20 | 6 | 98814 | 17129 | 50489175 |
Taste disorder | 17.08 | 10.20 | 45 | 98775 | 8279 | 50498025 |
Liver disorder | 17.05 | 10.20 | 29 | 98791 | 37193 | 50469111 |
Oedema peripheral | 17.01 | 10.20 | 212 | 98608 | 157749 | 50348555 |
Eczema eyelids | 16.96 | 10.20 | 7 | 98813 | 114 | 50506190 |
Nystagmus | 16.82 | 10.20 | 35 | 98785 | 5526 | 50500778 |
Tongue discolouration | 16.81 | 10.20 | 24 | 98796 | 2800 | 50503504 |
Depressed mood | 16.81 | 10.20 | 119 | 98701 | 33904 | 50472400 |
Plasma cell mastitis | 16.67 | 10.20 | 5 | 98815 | 29 | 50506275 |
Wound infection fungal | 16.63 | 10.20 | 7 | 98813 | 120 | 50506184 |
Personality disorder | 16.48 | 10.20 | 30 | 98790 | 4294 | 50502010 |
Inhibitory drug interaction | 16.37 | 10.20 | 21 | 98799 | 2212 | 50504092 |
Delirium | 16.28 | 10.20 | 129 | 98691 | 38063 | 50468241 |
Obstructive airways disorder | 16.16 | 10.20 | 67 | 98753 | 15585 | 50490719 |
Affective disorder | 16.14 | 10.20 | 33 | 98787 | 5148 | 50501156 |
Body height decreased | 16.13 | 10.20 | 46 | 98774 | 8862 | 50497442 |
Sepsis | 16.01 | 10.20 | 174 | 98646 | 132751 | 50373553 |
Screaming | 15.84 | 10.20 | 24 | 98796 | 2954 | 50503350 |
Hyperkalaemia | 15.82 | 10.20 | 45 | 98775 | 48044 | 50458260 |
Priapism | 15.76 | 10.20 | 6 | 98814 | 78 | 50506226 |
Anaphylactic shock | 15.66 | 10.20 | 10 | 98810 | 20145 | 50486159 |
Pleural effusion | 15.64 | 10.20 | 94 | 98726 | 81360 | 50424944 |
Small for dates baby | 15.55 | 10.20 | 26 | 98794 | 3479 | 50502825 |
Aspartate aminotransferase increased | 15.51 | 10.20 | 89 | 98731 | 77909 | 50428395 |
Drug dependence | 15.49 | 10.20 | 78 | 98742 | 19681 | 50486623 |
Restlessness | 15.46 | 10.20 | 93 | 98727 | 25080 | 50481224 |
Mitral valve thickening | 15.44 | 10.20 | 4 | 98816 | 12 | 50506292 |
Personal relationship issue | 15.41 | 10.20 | 5 | 98815 | 39 | 50506265 |
Hallucination, auditory | 15.33 | 10.20 | 51 | 98769 | 10677 | 50495627 |
Lung opacity | 15.17 | 10.20 | 19 | 98801 | 1954 | 50504350 |
Blood prolactin increased | 15.12 | 10.20 | 24 | 98796 | 3075 | 50503229 |
Blood calcium decreased | 15.12 | 10.20 | 11 | 98809 | 20695 | 50485609 |
Hepatocellular injury | 15.11 | 10.20 | 17 | 98803 | 25930 | 50480374 |
Balance disorder | 15.03 | 10.20 | 207 | 98613 | 70383 | 50435921 |
Nausea | 14.98 | 10.20 | 1584 | 97236 | 703814 | 49802490 |
Wheezing | 14.91 | 10.20 | 186 | 98634 | 61861 | 50444443 |
Polyglandular autoimmune syndrome type II | 14.78 | 10.20 | 5 | 98815 | 45 | 50506259 |
Mydriasis | 14.73 | 10.20 | 50 | 98770 | 10577 | 50495727 |
Large for dates baby | 14.71 | 10.20 | 10 | 98810 | 465 | 50505839 |
Inappropriate schedule of product administration | 14.64 | 10.20 | 209 | 98611 | 71622 | 50434682 |
Thyroglobulin increased | 14.49 | 10.20 | 5 | 98815 | 48 | 50506256 |
International normalised ratio increased | 14.47 | 10.20 | 40 | 98780 | 43112 | 50463192 |
Macular degeneration | 14.47 | 10.20 | 5 | 98815 | 14383 | 50491921 |
Productive cough | 14.44 | 10.20 | 162 | 98658 | 52532 | 50453772 |
Acute respiratory distress syndrome | 14.40 | 10.20 | 12 | 98808 | 21087 | 50485217 |
Weight decreased | 14.40 | 10.20 | 548 | 98272 | 220697 | 50285607 |
Live birth | 14.40 | 10.20 | 7 | 98813 | 16401 | 50489903 |
Urinary retention | 14.37 | 10.20 | 94 | 98726 | 26096 | 50480208 |
Red blood cell sedimentation rate increased | 14.34 | 10.20 | 22 | 98798 | 29394 | 50476910 |
Myoglobin blood increased | 14.25 | 10.20 | 15 | 98805 | 1278 | 50505026 |
Tracheitis | 14.24 | 10.20 | 12 | 98808 | 772 | 50505532 |
Neonatal seizure | 14.16 | 10.20 | 9 | 98811 | 373 | 50505931 |
Aspiration | 14.10 | 10.20 | 45 | 98775 | 9219 | 50497085 |
Drug reaction with eosinophilia and systemic symptoms | 14.10 | 10.20 | 21 | 98799 | 28403 | 50477901 |
Prescription drug used without a prescription | 14.09 | 10.20 | 17 | 98803 | 1683 | 50504621 |
Drug resistance | 13.98 | 10.20 | 10 | 98810 | 18979 | 50487325 |
Bone erosion | 13.74 | 10.20 | 3 | 98817 | 11684 | 50494620 |
Patient restraint | 13.65 | 10.20 | 3 | 98817 | 3 | 50506301 |
Gamma-glutamyltransferase increased | 13.64 | 10.20 | 23 | 98797 | 29600 | 50476704 |
Pregnancy | 13.59 | 10.20 | 23 | 98797 | 29554 | 50476750 |
Bronchopulmonary aspergillosis allergic | 13.46 | 10.20 | 14 | 98806 | 1177 | 50505127 |
Generalised oedema | 13.42 | 10.20 | 5 | 98815 | 13726 | 50492578 |
Deformity | 13.42 | 10.20 | 40 | 98780 | 7900 | 50498404 |
Peritoneal perforation | 13.41 | 10.20 | 6 | 98814 | 120 | 50506184 |
Anticholinergic syndrome | 13.35 | 10.20 | 17 | 98803 | 1778 | 50504526 |
Hepatotoxicity | 13.32 | 10.20 | 95 | 98725 | 27131 | 50479173 |
Ejection fraction decreased | 13.31 | 10.20 | 10 | 98810 | 18510 | 50487794 |
Pneumocystis jirovecii pneumonia | 13.26 | 10.20 | 6 | 98814 | 14657 | 50491647 |
Hyperthermia | 13.22 | 10.20 | 39 | 98781 | 7657 | 50498647 |
Arthralgia | 13.08 | 10.20 | 712 | 98108 | 437990 | 50068314 |
Metastases to liver | 13.04 | 10.20 | 12 | 98808 | 20092 | 50486212 |
Feeling abnormal | 13.01 | 10.20 | 329 | 98491 | 125163 | 50381141 |
Gastroenteritis radiation | 12.96 | 10.20 | 9 | 98811 | 433 | 50505871 |
Heterophoria | 12.95 | 10.20 | 4 | 98816 | 26 | 50506278 |
Tension | 12.94 | 10.20 | 21 | 98799 | 2741 | 50503563 |
Postural tremor | 12.94 | 10.20 | 7 | 98813 | 214 | 50506090 |
Confusional state | 12.94 | 10.20 | 464 | 98356 | 185464 | 50320840 |
Infection | 12.88 | 10.20 | 249 | 98571 | 172705 | 50333599 |
Product shape issue | 12.80 | 10.20 | 5 | 98815 | 70 | 50506234 |
Hypotension | 12.76 | 10.20 | 572 | 98248 | 234897 | 50271407 |
Economic problem | 12.71 | 10.20 | 17 | 98803 | 1865 | 50504439 |
Impaired quality of life | 12.69 | 10.20 | 33 | 98787 | 6023 | 50500281 |
Nervousness | 12.68 | 10.20 | 95 | 98725 | 27556 | 50478748 |
Coagulopathy | 12.50 | 10.20 | 10 | 98810 | 17934 | 50488370 |
Skin sensitisation | 12.48 | 10.20 | 11 | 98809 | 752 | 50505552 |
Deep vein thrombosis | 12.35 | 10.20 | 88 | 98732 | 73216 | 50433088 |
Holmes-Adie pupil | 12.35 | 10.20 | 4 | 98816 | 31 | 50506273 |
Hypothyroidism | 12.29 | 10.20 | 111 | 98709 | 34014 | 50472290 |
Urticaria | 12.09 | 10.20 | 179 | 98641 | 129382 | 50376922 |
Apraxia | 12.07 | 10.20 | 15 | 98805 | 1530 | 50504774 |
Rash maculo-papular | 11.98 | 10.20 | 21 | 98799 | 26620 | 50479684 |
Intervertebral disc degeneration | 11.90 | 10.20 | 55 | 98765 | 13406 | 50492898 |
Glucose tolerance impaired | 11.89 | 10.20 | 29 | 98791 | 5089 | 50501215 |
Palmar-plantar erythrodysaesthesia syndrome | 11.89 | 10.20 | 13 | 98807 | 20085 | 50486219 |
Wandering pacemaker | 11.84 | 10.20 | 3 | 98817 | 8 | 50506296 |
Inappropriate antidiuretic hormone secretion | 11.84 | 10.20 | 54 | 98766 | 13089 | 50493215 |
Device expulsion | 11.83 | 10.20 | 24 | 98796 | 28798 | 50477506 |
Apathy | 11.80 | 10.20 | 37 | 98783 | 7511 | 50498793 |
Decreased interest | 11.79 | 10.20 | 21 | 98799 | 2955 | 50503349 |
Serum serotonin increased | 11.67 | 10.20 | 6 | 98814 | 165 | 50506139 |
Immune-mediated lung disease | 11.63 | 10.20 | 8 | 98812 | 379 | 50505925 |
Hyponatriuria | 11.58 | 10.20 | 3 | 98817 | 9 | 50506295 |
Product complaint | 11.50 | 10.20 | 4 | 98816 | 11462 | 50494842 |
Knee deformity | 11.47 | 10.20 | 12 | 98808 | 1015 | 50505289 |
Knee arthroplasty | 11.45 | 10.20 | 34 | 98786 | 35812 | 50470492 |
Borderline personality disorder | 11.42 | 10.20 | 10 | 98810 | 678 | 50505626 |
Therapy non-responder | 11.38 | 10.20 | 56 | 98764 | 50966 | 50455338 |
Genital infection female | 11.36 | 10.20 | 5 | 98815 | 96 | 50506208 |
Morbid thoughts | 11.32 | 10.20 | 9 | 98811 | 533 | 50505771 |
Lung disorder | 11.29 | 10.20 | 47 | 98773 | 44752 | 50461552 |
Infection susceptibility increased | 11.24 | 10.20 | 19 | 98801 | 2565 | 50503739 |
Respiratory distress | 11.19 | 10.20 | 27 | 98793 | 30462 | 50475842 |
Injection site induration | 11.19 | 10.20 | 39 | 98781 | 8358 | 50497946 |
Angioedema | 11.15 | 10.20 | 37 | 98783 | 37639 | 50468665 |
Mood swings | 11.15 | 10.20 | 61 | 98759 | 15893 | 50490411 |
Immobile | 11.07 | 10.20 | 28 | 98792 | 5026 | 50501278 |
Compulsive shopping | 11.05 | 10.20 | 10 | 98810 | 708 | 50505596 |
Malignant melanoma | 11.01 | 10.20 | 44 | 98776 | 10064 | 50496240 |
Extra dose administered | 10.99 | 10.20 | 28 | 98792 | 5048 | 50501256 |
Hypertonia | 10.86 | 10.20 | 24 | 98796 | 3949 | 50502355 |
Parkinsonism | 10.86 | 10.20 | 40 | 98780 | 8807 | 50497497 |
Jaundice | 10.86 | 10.20 | 22 | 98798 | 26407 | 50479897 |
Alcohol withdrawal syndrome | 10.76 | 10.20 | 10 | 98810 | 733 | 50505571 |
Product size issue | 10.72 | 10.20 | 7 | 98813 | 304 | 50506000 |
Thinking abnormal | 10.71 | 10.20 | 42 | 98778 | 9525 | 50496779 |
Depressive symptom | 10.71 | 10.20 | 21 | 98799 | 3179 | 50503125 |
Product administered at inappropriate site | 10.67 | 10.20 | 18 | 98802 | 2425 | 50503879 |
Cross sensitivity reaction | 10.66 | 10.20 | 16 | 98804 | 1953 | 50504351 |
Electrocardiogram T wave peaked | 10.62 | 10.20 | 6 | 98814 | 200 | 50506104 |
Long QT syndrome | 10.57 | 10.20 | 20 | 98800 | 2947 | 50503357 |
Drug diversion | 10.51 | 10.20 | 10 | 98810 | 755 | 50505549 |
Gastrointestinal haemorrhage | 10.50 | 10.20 | 92 | 98728 | 73229 | 50433075 |
Cardiomyopathy | 10.47 | 10.20 | 9 | 98811 | 15577 | 50490727 |
Dementia | 10.40 | 10.20 | 60 | 98760 | 15937 | 50490367 |
Interstitial lung disease | 10.40 | 10.20 | 61 | 98759 | 53115 | 50453189 |
Aspartate aminotransferase decreased | 10.39 | 10.20 | 9 | 98811 | 601 | 50505703 |
Autoimmune nephritis | 10.38 | 10.20 | 7 | 98813 | 321 | 50505983 |
Product packaging difficult to open | 10.37 | 10.20 | 4 | 98816 | 54 | 50506250 |
Impaired gastric emptying | 10.36 | 10.20 | 39 | 98781 | 8679 | 50497625 |
Rheumatoid nodule | 10.34 | 10.20 | 6 | 98814 | 12729 | 50493575 |
Alcohol poisoning | 10.28 | 10.20 | 15 | 98805 | 1785 | 50504519 |
Dizziness | 10.24 | 10.20 | 797 | 98023 | 345572 | 50160732 |
Kluver-Bucy syndrome | 10.22 | 10.20 | 3 | 98817 | 16 | 50506288 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 473.33 | 11.49 | 620 | 42684 | 89626 | 29441597 |
Serotonin syndrome | 401.44 | 11.49 | 274 | 43030 | 17238 | 29513985 |
Priapism | 357.63 | 11.49 | 160 | 43144 | 4328 | 29526895 |
Toxicity to various agents | 354.04 | 11.49 | 782 | 42522 | 172879 | 29358344 |
Drug abuse | 288.23 | 11.49 | 460 | 42844 | 79423 | 29451800 |
Sopor | 245.56 | 11.49 | 169 | 43135 | 10765 | 29520458 |
Overdose | 121.70 | 11.49 | 322 | 42982 | 79497 | 29451726 |
Suicidal ideation | 119.59 | 11.49 | 196 | 43108 | 34520 | 29496703 |
Intentional overdose | 109.77 | 11.49 | 200 | 43104 | 38328 | 29492895 |
Suicide attempt | 88.34 | 11.49 | 170 | 43134 | 33940 | 29497283 |
Drug interaction | 80.47 | 11.49 | 529 | 42775 | 196856 | 29334367 |
Cardio-respiratory arrest | 77.92 | 11.49 | 205 | 43099 | 50396 | 29480827 |
Somnolence | 76.53 | 11.49 | 306 | 42998 | 93649 | 29437574 |
Electrocardiogram QT prolonged | 75.71 | 11.49 | 165 | 43139 | 35972 | 29495251 |
Intrusive thoughts | 72.15 | 11.49 | 23 | 43281 | 232 | 29530991 |
Agitation | 71.15 | 11.49 | 200 | 43104 | 51104 | 29480119 |
Insomnia | 69.82 | 11.49 | 286 | 43018 | 88475 | 29442748 |
Anxiety | 68.69 | 11.49 | 277 | 43027 | 85088 | 29446135 |
Depression | 65.11 | 11.49 | 272 | 43032 | 84875 | 29446348 |
Febrile neutropenia | 63.86 | 11.49 | 43 | 43261 | 112197 | 29419026 |
Ventricular tachyarrhythmia | 49.40 | 11.49 | 18 | 43286 | 280 | 29530943 |
Pancytopenia | 48.46 | 11.49 | 31 | 43273 | 83137 | 29448086 |
Anaemia | 47.60 | 11.49 | 144 | 43160 | 200807 | 29330416 |
Environmental exposure | 47.53 | 11.49 | 17 | 43287 | 250 | 29530973 |
Homicidal ideation | 47.39 | 11.49 | 35 | 43269 | 2489 | 29528734 |
Intentional product misuse | 46.93 | 11.49 | 134 | 43170 | 34527 | 29496696 |
Antidepressant drug level above therapeutic | 45.81 | 11.49 | 15 | 43289 | 166 | 29531057 |
Mental status changes | 45.34 | 11.49 | 133 | 43171 | 34794 | 29496429 |
Paranoia | 44.20 | 11.49 | 63 | 43241 | 9814 | 29521409 |
Tachyphrenia | 43.75 | 11.49 | 25 | 43279 | 1144 | 29530079 |
Aggression | 42.05 | 11.49 | 131 | 43173 | 35410 | 29495813 |
Renal failure | 42.03 | 11.49 | 68 | 43236 | 118531 | 29412692 |
Analgesic drug level above therapeutic | 40.60 | 11.49 | 15 | 43289 | 243 | 29530980 |
Drug withdrawal syndrome neonatal | 40.26 | 11.49 | 36 | 43268 | 3359 | 29527864 |
Thrombocytopenia | 40.10 | 11.49 | 86 | 43218 | 134737 | 29396486 |
Confusional state | 39.48 | 11.49 | 321 | 42983 | 127556 | 29403667 |
Symptom masked | 38.64 | 11.49 | 18 | 43286 | 535 | 29530688 |
Irritability | 38.50 | 11.49 | 94 | 43210 | 22058 | 29509165 |
Product dose omission issue | 38.33 | 11.49 | 257 | 43047 | 96126 | 29435097 |
Sedation | 37.03 | 11.49 | 80 | 43224 | 17325 | 29513898 |
Anger | 36.81 | 11.49 | 61 | 43243 | 10829 | 29520394 |
Parkinsonism | 36.43 | 11.49 | 49 | 43255 | 7229 | 29523994 |
Head discomfort | 35.74 | 11.49 | 33 | 43271 | 3209 | 29528014 |
Alcoholism | 35.14 | 11.49 | 30 | 43274 | 2631 | 29528592 |
Interstitial lung disease | 34.32 | 11.49 | 21 | 43283 | 57697 | 29473526 |
Withdrawal syndrome | 33.76 | 11.49 | 59 | 43245 | 10933 | 29520290 |
Bradyphrenia | 33.68 | 11.49 | 36 | 43268 | 4178 | 29527045 |
Penis injury | 33.33 | 11.49 | 13 | 43291 | 246 | 29530977 |
Intentional self-injury | 32.11 | 11.49 | 62 | 43242 | 12399 | 29518824 |
Restless legs syndrome | 31.92 | 11.49 | 45 | 43259 | 6939 | 29524284 |
Respiratory arrest | 31.28 | 11.49 | 96 | 43208 | 25737 | 29505486 |
Pyrexia | 30.94 | 11.49 | 271 | 43033 | 287351 | 29243872 |
Dysphoria | 30.55 | 11.49 | 25 | 43279 | 2067 | 29529156 |
Shock | 30.19 | 11.49 | 84 | 43220 | 21320 | 29509903 |
Delusion of replacement | 29.88 | 11.49 | 10 | 43294 | 119 | 29531104 |
Poor feeding infant | 29.33 | 11.49 | 14 | 43290 | 440 | 29530783 |
Septic shock | 29.29 | 11.49 | 29 | 43275 | 62531 | 29468692 |
Injection site reaction | 29.23 | 11.49 | 56 | 43248 | 11132 | 29520091 |
Sleep disorder | 28.94 | 11.49 | 90 | 43214 | 24296 | 29506927 |
Renal impairment | 28.45 | 11.49 | 47 | 43257 | 81286 | 29449937 |
Persistent depressive disorder | 28.29 | 11.49 | 12 | 43292 | 284 | 29530939 |
Tremor | 27.39 | 11.49 | 193 | 43111 | 73345 | 29457878 |
Homicide | 27.31 | 11.49 | 17 | 43287 | 911 | 29530312 |
Pruritus genital | 27.03 | 11.49 | 14 | 43290 | 526 | 29530697 |
Delusion | 26.72 | 11.49 | 54 | 43250 | 11162 | 29520061 |
Loss of libido | 26.54 | 11.49 | 24 | 43280 | 2272 | 29528951 |
Initial insomnia | 26.33 | 11.49 | 26 | 43278 | 2749 | 29528474 |
Hallucination, auditory | 26.28 | 11.49 | 49 | 43255 | 9544 | 29521679 |
Disease progression | 26.25 | 11.49 | 50 | 43254 | 81866 | 29449357 |
Foaming at mouth | 26.02 | 11.49 | 15 | 43289 | 698 | 29530525 |
Neutropenia | 25.98 | 11.49 | 102 | 43202 | 131609 | 29399614 |
Penile haemorrhage | 25.55 | 11.49 | 14 | 43290 | 590 | 29530633 |
Pre-existing condition improved | 24.97 | 11.49 | 23 | 43281 | 2230 | 29528993 |
Hyperreflexia | 24.51 | 11.49 | 25 | 43279 | 2747 | 29528476 |
General physical health deterioration | 24.09 | 11.49 | 74 | 43230 | 102783 | 29428440 |
Distributive shock | 23.95 | 11.49 | 16 | 43288 | 969 | 29530254 |
Polymerase chain reaction | 23.92 | 11.49 | 8 | 43296 | 95 | 29531128 |
Clonus | 23.91 | 11.49 | 23 | 43281 | 2355 | 29528868 |
Accidental poisoning | 23.79 | 11.49 | 13 | 43291 | 545 | 29530678 |
Cytomegalovirus infection | 23.72 | 11.49 | 3 | 43301 | 23212 | 29508011 |
Eye haematoma | 23.08 | 11.49 | 7 | 43297 | 59 | 29531164 |
Psychomotor retardation | 23.04 | 11.49 | 25 | 43279 | 2951 | 29528272 |
Neck pain | 22.60 | 11.49 | 76 | 43228 | 21371 | 29509852 |
Hallucination, visual | 22.24 | 11.49 | 60 | 43244 | 14955 | 29516268 |
Bite | 22.10 | 11.49 | 7 | 43297 | 69 | 29531154 |
Fall | 22.01 | 11.49 | 373 | 42931 | 176805 | 29354418 |
Hallucination | 22.00 | 11.49 | 126 | 43178 | 44586 | 29486637 |
Death | 21.87 | 11.49 | 655 | 42649 | 341429 | 29189794 |
Nightmare | 21.51 | 11.49 | 50 | 43254 | 11367 | 29519856 |
Alcohol interaction | 21.44 | 11.49 | 23 | 43281 | 2680 | 29528543 |
International normalised ratio increased | 21.43 | 11.49 | 20 | 43284 | 44352 | 29486871 |
Painful erection | 21.25 | 11.49 | 9 | 43295 | 212 | 29531011 |
Restlessness | 21.18 | 11.49 | 76 | 43228 | 22069 | 29509154 |
Mood swings | 21.08 | 11.49 | 38 | 43266 | 7213 | 29524010 |
Hepatic function abnormal | 21.04 | 11.49 | 16 | 43288 | 39243 | 29491980 |
Reduced facial expression | 20.95 | 11.49 | 13 | 43291 | 693 | 29530530 |
Accidental overdose | 20.94 | 11.49 | 65 | 43239 | 17528 | 29513695 |
Sleep deficit | 20.77 | 11.49 | 11 | 43293 | 433 | 29530790 |
Nervousness | 20.74 | 11.49 | 49 | 43255 | 11257 | 29519966 |
Myotonia | 20.51 | 11.49 | 6 | 43298 | 44 | 29531179 |
Alanine aminotransferase increased | 20.45 | 11.49 | 46 | 43258 | 70898 | 29460325 |
Food aversion | 20.28 | 11.49 | 10 | 43294 | 338 | 29530885 |
Brain injury | 20.16 | 11.49 | 32 | 43272 | 5480 | 29525743 |
Congenital pneumonia | 20.08 | 11.49 | 7 | 43297 | 95 | 29531128 |
Erectile dysfunction | 20.03 | 11.49 | 65 | 43239 | 17944 | 29513279 |
Illness anxiety disorder | 19.97 | 11.49 | 8 | 43296 | 163 | 29531060 |
Tardive dyskinesia | 19.89 | 11.49 | 31 | 43273 | 5227 | 29525996 |
Poor quality sleep | 19.88 | 11.49 | 37 | 43267 | 7196 | 29524027 |
Sepsis | 19.80 | 11.49 | 125 | 43179 | 142557 | 29388666 |
Migraine | 19.76 | 11.49 | 51 | 43253 | 12379 | 29518844 |
Muscle rigidity | 19.72 | 11.49 | 43 | 43261 | 9368 | 29521855 |
Psychotic disorder | 19.59 | 11.49 | 70 | 43234 | 20284 | 29510939 |
Atrial fibrillation | 19.46 | 11.49 | 84 | 43220 | 105562 | 29425661 |
Platelet count decreased | 19.42 | 11.49 | 83 | 43221 | 104589 | 29426634 |
Dry mouth | 19.36 | 11.49 | 73 | 43231 | 21711 | 29509512 |
Sleep sex | 19.35 | 11.49 | 4 | 43300 | 4 | 29531219 |
Feeling abnormal | 19.17 | 11.49 | 141 | 43163 | 54304 | 29476919 |
Blood cholinesterase decreased | 19.03 | 11.49 | 7 | 43297 | 112 | 29531111 |
Substance abuse | 19.01 | 11.49 | 35 | 43269 | 6752 | 29524471 |
C-reactive protein | 18.91 | 11.49 | 7 | 43297 | 114 | 29531109 |
Delirium | 18.72 | 11.49 | 110 | 43194 | 39287 | 29491936 |
Procedural failure | 18.27 | 11.49 | 6 | 43298 | 67 | 29531156 |
Mucosal inflammation | 18.08 | 11.49 | 12 | 43292 | 31583 | 29499640 |
Paedophilia | 18.08 | 11.49 | 4 | 43300 | 7 | 29531216 |
Sprue-like enteropathy | 18.07 | 11.49 | 10 | 43294 | 430 | 29530793 |
Derealisation | 18.04 | 11.49 | 11 | 43293 | 568 | 29530655 |
Depersonalisation/derealisation disorder | 18.01 | 11.49 | 11 | 43293 | 570 | 29530653 |
Hypertonia | 17.98 | 11.49 | 25 | 43279 | 3804 | 29527419 |
Akathisia | 17.93 | 11.49 | 34 | 43270 | 6708 | 29524515 |
Hyperhidrosis | 17.76 | 11.49 | 158 | 43146 | 64382 | 29466841 |
Bone marrow failure | 17.74 | 11.49 | 9 | 43295 | 27440 | 29503783 |
Neuroleptic malignant syndrome | 17.70 | 11.49 | 58 | 43246 | 16090 | 29515133 |
Delirium febrile | 17.68 | 11.49 | 5 | 43299 | 32 | 29531191 |
Obsessive thoughts | 17.32 | 11.49 | 11 | 43293 | 611 | 29530612 |
Hangover | 17.12 | 11.49 | 13 | 43291 | 964 | 29530259 |
Ascites | 17.11 | 11.49 | 17 | 43287 | 36602 | 29494621 |
Depressed mood | 17.07 | 11.49 | 58 | 43246 | 16390 | 29514833 |
Blood urea increased | 17.02 | 11.49 | 10 | 43294 | 28102 | 29503121 |
Post-traumatic stress disorder | 16.90 | 11.49 | 16 | 43288 | 1606 | 29529617 |
Erection increased | 16.84 | 11.49 | 10 | 43294 | 492 | 29530731 |
General symptom | 16.72 | 11.49 | 12 | 43292 | 816 | 29530407 |
Generalised anxiety disorder | 16.71 | 11.49 | 11 | 43293 | 650 | 29530573 |
Catatonia | 16.42 | 11.49 | 26 | 43278 | 4442 | 29526781 |
Euphoric mood | 16.27 | 11.49 | 27 | 43277 | 4798 | 29526425 |
Amnesia | 16.24 | 11.49 | 71 | 43233 | 22572 | 29508651 |
Cholestasis | 16.23 | 11.49 | 7 | 43297 | 23455 | 29507768 |
Bipolar disorder | 16.21 | 11.49 | 22 | 43282 | 3273 | 29527950 |
Product administered at inappropriate site | 16.10 | 11.49 | 16 | 43288 | 1704 | 29529519 |
Sleep-related eating disorder | 16.02 | 11.49 | 8 | 43296 | 278 | 29530945 |
Periorbital haemorrhage | 15.76 | 11.49 | 6 | 43298 | 106 | 29531117 |
Drug withdrawal syndrome | 15.76 | 11.49 | 60 | 43244 | 17924 | 29513299 |
Wrong patient received product | 15.66 | 11.49 | 18 | 43286 | 2264 | 29528959 |
Rash maculo-papular | 15.64 | 11.49 | 8 | 43296 | 24281 | 29506942 |
Acute pulmonary oedema | 15.39 | 11.49 | 32 | 43272 | 6747 | 29524476 |
Drug screen positive | 15.20 | 11.49 | 23 | 43281 | 3778 | 29527445 |
Homeless | 15.14 | 11.49 | 4 | 43300 | 19 | 29531204 |
Injection site mass | 15.11 | 11.49 | 28 | 43276 | 5427 | 29525796 |
Hanging | 15.08 | 11.49 | 6 | 43298 | 120 | 29531103 |
Sexual dysfunction | 15.06 | 11.49 | 29 | 43275 | 5785 | 29525438 |
Diabetic foetopathy | 14.94 | 11.49 | 7 | 43297 | 211 | 29531012 |
Discoloured vomit | 14.90 | 11.49 | 9 | 43295 | 457 | 29530766 |
Dementia | 14.74 | 11.49 | 44 | 43260 | 11614 | 29519609 |
Respiratory disorder neonatal | 14.74 | 11.49 | 14 | 43290 | 1411 | 29529812 |
Myelodysplastic syndrome | 14.57 | 11.49 | 4 | 43300 | 17790 | 29513433 |
Nicotine dependence | 14.53 | 11.49 | 9 | 43295 | 478 | 29530745 |
Urine amphetamine positive | 14.51 | 11.49 | 4 | 43300 | 23 | 29531200 |
Headache | 14.46 | 11.49 | 345 | 42959 | 173662 | 29357561 |
Blood bilirubin increased | 14.43 | 11.49 | 17 | 43287 | 33876 | 29497347 |
Blood creatinine increased | 14.28 | 11.49 | 70 | 43234 | 85032 | 29446191 |
Suspected suicide | 14.24 | 11.49 | 23 | 43281 | 3997 | 29527226 |
Drug use disorder | 14.11 | 11.49 | 21 | 43283 | 3401 | 29527822 |
Lactic acidosis | 14.07 | 11.49 | 84 | 43220 | 30163 | 29501060 |
Malignant neoplasm progression | 14.04 | 11.49 | 58 | 43246 | 73801 | 29457422 |
Erythema | 13.98 | 11.49 | 60 | 43244 | 75546 | 29455677 |
Lower respiratory tract infection | 13.95 | 11.49 | 11 | 43293 | 26491 | 29504732 |
Pulmonary congestion | 13.93 | 11.49 | 45 | 43259 | 12391 | 29518832 |
Device malfunction | 13.62 | 11.49 | 35 | 43269 | 8472 | 29522751 |
Sudden cardiac death | 13.61 | 11.49 | 20 | 43284 | 3202 | 29528021 |
Gambling disorder | 13.56 | 11.49 | 14 | 43290 | 1561 | 29529662 |
Device dislocation | 13.51 | 11.49 | 24 | 43280 | 4503 | 29526720 |
Dyspnoea | 13.47 | 11.49 | 370 | 42934 | 326362 | 29204861 |
Cardiac failure | 13.42 | 11.49 | 65 | 43239 | 79222 | 29452001 |
Stress at work | 13.41 | 11.49 | 6 | 43298 | 162 | 29531061 |
Urine leukocyte esterase positive | 13.41 | 11.49 | 8 | 43296 | 397 | 29530826 |
Pleural effusion | 13.34 | 11.49 | 57 | 43247 | 71851 | 29459372 |
Substance use disorder | 13.32 | 11.49 | 7 | 43297 | 271 | 29530952 |
Eosinophilia | 13.25 | 11.49 | 8 | 43296 | 22153 | 29509070 |
Haemoglobin decreased | 13.02 | 11.49 | 99 | 43205 | 108276 | 29422947 |
Withdrawal catatonia | 13.00 | 11.49 | 5 | 43299 | 91 | 29531132 |
Osteonecrosis of jaw | 12.98 | 11.49 | 4 | 43300 | 16506 | 29514717 |
Obsessive rumination | 12.98 | 11.49 | 3 | 43301 | 7 | 29531216 |
Needle issue | 12.93 | 11.49 | 24 | 43280 | 4659 | 29526564 |
Leukopenia | 12.71 | 11.49 | 40 | 43264 | 55163 | 29476060 |
Abnormal dreams | 12.70 | 11.49 | 30 | 43274 | 6890 | 29524333 |
Depressed level of consciousness | 12.62 | 11.49 | 95 | 43209 | 36847 | 29494376 |
Exposure via breast milk | 12.59 | 11.49 | 14 | 43290 | 1698 | 29529525 |
Aspartate aminotransferase increased | 12.57 | 11.49 | 45 | 43259 | 59680 | 29471543 |
Drug resistance | 12.57 | 11.49 | 8 | 43296 | 21532 | 29509691 |
Gastrointestinal haemorrhage | 12.45 | 11.49 | 67 | 43237 | 79466 | 29451757 |
Physical disability | 12.36 | 11.49 | 12 | 43292 | 1242 | 29529981 |
Ventricular tachycardia | 12.35 | 11.49 | 9 | 43295 | 22565 | 29508658 |
Multiple organ dysfunction syndrome | 12.35 | 11.49 | 49 | 43255 | 63067 | 29468156 |
Hospitalisation | 12.34 | 11.49 | 112 | 43192 | 45876 | 29485347 |
Cardiac failure congestive | 12.27 | 11.49 | 64 | 43240 | 76517 | 29454706 |
Premature baby | 12.20 | 11.49 | 5 | 43299 | 17275 | 29513948 |
Hepatic failure | 12.18 | 11.49 | 17 | 43287 | 31495 | 29499728 |
Obsessive-compulsive disorder | 12.07 | 11.49 | 23 | 43281 | 4553 | 29526670 |
Genital haemorrhage | 11.96 | 11.49 | 5 | 43299 | 114 | 29531109 |
Drug reaction with eosinophilia and systemic symptoms | 11.96 | 11.49 | 14 | 43290 | 27978 | 29503245 |
Blood glucose fluctuation | 11.96 | 11.49 | 20 | 43284 | 3577 | 29527646 |
Pulmonary fibrosis | 11.86 | 11.49 | 4 | 43300 | 15578 | 29515645 |
Oedema peripheral | 11.79 | 11.49 | 96 | 43208 | 103461 | 29427762 |
Catecholamines urine increased | 11.77 | 11.49 | 3 | 43301 | 12 | 29531211 |
Antipsychotic drug level above therapeutic | 11.74 | 11.49 | 11 | 43293 | 1090 | 29530133 |
Application site hypersensitivity | 11.72 | 11.49 | 5 | 43299 | 120 | 29531103 |
Respiratory failure | 11.54 | 11.49 | 89 | 43215 | 97042 | 29434181 |
Agitated depression | 11.52 | 11.49 | 6 | 43298 | 228 | 29530995 |
Heat stroke | 11.50 | 11.49 | 10 | 43294 | 899 | 29530324 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1416.11 | 10.15 | 1915 | 119093 | 222499 | 64155225 |
Serotonin syndrome | 699.61 | 10.15 | 584 | 120424 | 38698 | 64339026 |
Toxicity to various agents | 651.86 | 10.15 | 1818 | 119190 | 361695 | 64016029 |
Drug abuse | 646.41 | 10.15 | 1002 | 120006 | 131372 | 64246352 |
Sopor | 599.90 | 10.15 | 475 | 120533 | 29186 | 64348538 |
Priapism | 350.62 | 10.15 | 164 | 120844 | 3806 | 64373918 |
Suicide attempt | 214.54 | 10.15 | 436 | 120572 | 70571 | 64307153 |
Cardio-respiratory arrest | 204.64 | 10.15 | 521 | 120487 | 97872 | 64279852 |
Overdose | 203.22 | 10.15 | 710 | 120298 | 158856 | 64218868 |
Suicidal ideation | 173.71 | 10.15 | 385 | 120623 | 66157 | 64311567 |
Polycystic ovaries | 156.92 | 10.15 | 78 | 120930 | 2077 | 64375647 |
Drug interaction | 155.29 | 10.15 | 1186 | 119822 | 360897 | 64016827 |
Electrocardiogram QT prolonged | 148.15 | 10.15 | 404 | 120604 | 79044 | 64298680 |
Intentional overdose | 135.66 | 10.15 | 424 | 120584 | 89520 | 64288204 |
Withdrawal syndrome | 117.43 | 10.15 | 180 | 120828 | 23312 | 64354412 |
Presbyacusis | 114.03 | 10.15 | 67 | 120941 | 2508 | 64375216 |
Febrile neutropenia | 113.18 | 10.15 | 111 | 120897 | 187546 | 64190178 |
Hypomania | 106.71 | 10.15 | 87 | 120921 | 5567 | 64372157 |
Sensitisation | 101.06 | 10.15 | 54 | 120954 | 1677 | 64376047 |
Hand deformity | 100.29 | 10.15 | 4 | 121004 | 62767 | 64314957 |
Migraine | 98.70 | 10.15 | 300 | 120708 | 62377 | 64315347 |
Pancytopenia | 94.49 | 10.15 | 78 | 120930 | 143231 | 64234493 |
Depression | 94.43 | 10.15 | 628 | 120380 | 182663 | 64195061 |
Anxiety | 94.18 | 10.15 | 677 | 120331 | 201972 | 64175752 |
Thrombocytopenia | 93.74 | 10.15 | 173 | 120835 | 223628 | 64154096 |
Pleural thickening | 93.19 | 10.15 | 60 | 120948 | 2650 | 64375074 |
Neutropenia | 91.12 | 10.15 | 196 | 120812 | 239428 | 64138296 |
Agitation | 89.01 | 10.15 | 365 | 120643 | 88002 | 64289722 |
Pleural fibrosis | 88.64 | 10.15 | 68 | 120940 | 3982 | 64373742 |
Blood magnesium increased | 88.23 | 10.15 | 62 | 120946 | 3169 | 64374555 |
Anaemia | 86.98 | 10.15 | 390 | 120618 | 378290 | 63999434 |
Ejection fraction | 83.28 | 10.15 | 43 | 120965 | 1243 | 64376481 |
Pericarditis | 80.30 | 10.15 | 11 | 120997 | 62505 | 64315219 |
Pyrexia | 79.80 | 10.15 | 668 | 120340 | 557976 | 63819748 |
Maternal exposure during pregnancy | 78.34 | 10.15 | 41 | 120967 | 95843 | 64281881 |
Intentional self-injury | 76.83 | 10.15 | 169 | 120839 | 28875 | 64348849 |
General physical health deterioration | 76.22 | 10.15 | 169 | 120839 | 204256 | 64173468 |
Schizophrenia | 75.71 | 10.15 | 99 | 120909 | 11069 | 64366655 |
Product dose omission issue | 74.03 | 10.15 | 621 | 120387 | 194126 | 64183598 |
Insomnia | 73.70 | 10.15 | 628 | 120380 | 197208 | 64180516 |
Somnolence | 69.93 | 10.15 | 635 | 120373 | 203010 | 64174714 |
Respiratory arrest | 69.27 | 10.15 | 238 | 120770 | 52747 | 64324977 |
Hyperreflexia | 69.26 | 10.15 | 76 | 120932 | 7072 | 64370652 |
Rash | 69.24 | 10.15 | 540 | 120468 | 458009 | 63919715 |
Swelling | 66.92 | 10.15 | 124 | 120884 | 160094 | 64217630 |
Infusion related reaction | 66.32 | 10.15 | 130 | 120878 | 164337 | 64213387 |
Psychotic disorder | 65.58 | 10.15 | 177 | 120831 | 34401 | 64343323 |
Systemic lupus erythematosus | 65.18 | 10.15 | 32 | 120976 | 77580 | 64300144 |
Renal failure | 64.65 | 10.15 | 154 | 120854 | 181534 | 64196190 |
Memory impairment | 64.65 | 10.15 | 325 | 120683 | 85357 | 64292367 |
Irritability | 64.65 | 10.15 | 183 | 120825 | 36563 | 64341161 |
Deafness neurosensory | 63.91 | 10.15 | 69 | 120939 | 6305 | 64371419 |
Synovitis | 62.78 | 10.15 | 56 | 120952 | 99034 | 64278690 |
Bradyphrenia | 61.63 | 10.15 | 82 | 120926 | 9324 | 64368400 |
Myocardial stunning | 61.11 | 10.15 | 20 | 120988 | 168 | 64377556 |
Malignant neoplasm progression | 61.10 | 10.15 | 73 | 120935 | 112798 | 64264926 |
Platelet count decreased | 60.59 | 10.15 | 141 | 120867 | 167570 | 64210154 |
Blood test abnormal | 60.26 | 10.15 | 96 | 120912 | 12847 | 64364877 |
Nightmare | 58.78 | 10.15 | 125 | 120883 | 20868 | 64356856 |
Mental status changes | 58.73 | 10.15 | 249 | 120759 | 60913 | 64316811 |
Tremor | 58.62 | 10.15 | 477 | 120531 | 147753 | 64229971 |
Mucosal inflammation | 58.61 | 10.15 | 22 | 120986 | 62562 | 64315162 |
Intrusive thoughts | 58.39 | 10.15 | 23 | 120985 | 344 | 64377380 |
Wound | 57.75 | 10.15 | 36 | 120972 | 76441 | 64301283 |
Neovascularisation | 57.71 | 10.15 | 32 | 120976 | 1071 | 64376653 |
Suspected suicide | 57.56 | 10.15 | 76 | 120932 | 8578 | 64369146 |
Sleep disorder | 57.26 | 10.15 | 243 | 120765 | 59466 | 64318258 |
Intentional product misuse | 57.23 | 10.15 | 278 | 120730 | 72017 | 64305707 |
Accidental poisoning | 57.07 | 10.15 | 35 | 120973 | 1418 | 64376306 |
Epigastric discomfort | 56.81 | 10.15 | 67 | 120941 | 6744 | 64370980 |
Rhinitis allergic | 55.37 | 10.15 | 72 | 120936 | 8006 | 64369718 |
Exposure during pregnancy | 55.37 | 10.15 | 39 | 120969 | 77636 | 64300088 |
Haemoglobin decreased | 54.90 | 10.15 | 185 | 120823 | 194878 | 64182846 |
Sleep disorder due to a general medical condition | 54.28 | 10.15 | 72 | 120936 | 8162 | 64369562 |
Sedation | 53.98 | 10.15 | 186 | 120822 | 41276 | 64336448 |
Carpal tunnel syndrome | 53.58 | 10.15 | 102 | 120906 | 15726 | 64361998 |
Confabulation | 53.42 | 10.15 | 23 | 120985 | 436 | 64377288 |
Alcoholism | 53.05 | 10.15 | 47 | 120961 | 3370 | 64374354 |
Joint swelling | 52.94 | 10.15 | 216 | 120792 | 215166 | 64162558 |
Sleep apnoea syndrome | 51.92 | 10.15 | 148 | 120860 | 29684 | 64348040 |
Hyper IgE syndrome | 51.75 | 10.15 | 23 | 120985 | 472 | 64377252 |
Jaundice cholestatic | 51.39 | 10.15 | 72 | 120936 | 8598 | 64369126 |
Injection site mass | 50.88 | 10.15 | 105 | 120903 | 17165 | 64360559 |
Bone cyst | 50.54 | 10.15 | 38 | 120970 | 2159 | 64375565 |
Akathisia | 50.36 | 10.15 | 83 | 120925 | 11427 | 64366297 |
Septic shock | 50.14 | 10.15 | 75 | 120933 | 105362 | 64272362 |
Poor quality sleep | 49.81 | 10.15 | 110 | 120898 | 18841 | 64358883 |
Cytomegalovirus infection | 49.09 | 10.15 | 6 | 121002 | 37193 | 64340531 |
Gastrooesophageal reflux disease | 48.41 | 10.15 | 294 | 120714 | 82849 | 64294875 |
Bone marrow failure | 48.12 | 10.15 | 15 | 120993 | 47937 | 64329787 |
Glossodynia | 48.10 | 10.15 | 31 | 120977 | 64665 | 64313059 |
Lung diffusion test abnormal | 47.82 | 10.15 | 16 | 120992 | 145 | 64377579 |
Acute kidney injury | 47.49 | 10.15 | 577 | 120431 | 448663 | 63929061 |
Extrapyramidal disorder | 46.41 | 10.15 | 109 | 120899 | 19443 | 64358281 |
Cardiac failure | 45.66 | 10.15 | 114 | 120894 | 132259 | 64245465 |
Visual perseveration | 45.48 | 10.15 | 13 | 120995 | 65 | 64377659 |
Sepsis | 45.46 | 10.15 | 250 | 120758 | 230091 | 64147633 |
Cholestasis | 45.09 | 10.15 | 14 | 120994 | 44858 | 64332866 |
Hepatic function abnormal | 44.91 | 10.15 | 33 | 120975 | 64280 | 64313444 |
Folliculitis | 44.64 | 10.15 | 3 | 121005 | 30074 | 64347650 |
Leukopenia | 44.38 | 10.15 | 76 | 120932 | 101166 | 64276558 |
Tachyphrenia | 44.38 | 10.15 | 33 | 120975 | 1843 | 64375881 |
Depressed level of consciousness | 44.30 | 10.15 | 283 | 120725 | 81153 | 64296571 |
Cyst | 43.83 | 10.15 | 80 | 120928 | 11947 | 64365777 |
Fibromyalgia | 43.68 | 10.15 | 157 | 120851 | 35574 | 64342150 |
Fall | 43.52 | 10.15 | 1056 | 119952 | 415770 | 63961954 |
Clonus | 43.03 | 10.15 | 55 | 120953 | 6012 | 64371712 |
Helicobacter infection | 42.25 | 10.15 | 10 | 120998 | 38352 | 64339372 |
Muscle rigidity | 42.12 | 10.15 | 98 | 120910 | 17375 | 64360349 |
Oral discomfort | 41.43 | 10.15 | 64 | 120944 | 8342 | 64369382 |
Persistent genital arousal disorder | 41.26 | 10.15 | 16 | 120992 | 229 | 64377495 |
Head discomfort | 40.97 | 10.15 | 77 | 120931 | 11757 | 64365967 |
Alanine aminotransferase increased | 40.38 | 10.15 | 130 | 120878 | 138901 | 64238823 |
C-reactive protein abnormal | 40.06 | 10.15 | 4 | 121004 | 29043 | 64348681 |
Anger | 39.84 | 10.15 | 90 | 120918 | 15651 | 64362073 |
Adjustment disorder with mixed anxiety and depressed mood | 39.73 | 10.15 | 12 | 120996 | 75 | 64377649 |
Paradoxical drug reaction | 39.55 | 10.15 | 53 | 120955 | 6067 | 64371657 |
Restless legs syndrome | 39.09 | 10.15 | 94 | 120914 | 17022 | 64360702 |
Reduced facial expression | 38.80 | 10.15 | 32 | 120976 | 2081 | 64375643 |
Environmental exposure | 38.60 | 10.15 | 17 | 120991 | 341 | 64377383 |
Dry eye | 38.49 | 10.15 | 131 | 120877 | 28888 | 64348836 |
Osteopenia | 38.38 | 10.15 | 88 | 120920 | 15452 | 64362272 |
Penis injury | 38.17 | 10.15 | 13 | 120995 | 125 | 64377599 |
Hostility | 37.58 | 10.15 | 32 | 120976 | 2175 | 64375549 |
Drug resistance | 37.02 | 10.15 | 10 | 120998 | 35092 | 64342632 |
Asphyxia | 36.61 | 10.15 | 65 | 120943 | 9501 | 64368223 |
Interstitial lung disease | 36.23 | 10.15 | 81 | 120927 | 97651 | 64280073 |
Impaired healing | 36.16 | 10.15 | 36 | 120972 | 60437 | 64317287 |
Disease progression | 36.12 | 10.15 | 140 | 120868 | 141540 | 64236184 |
Cardiac failure congestive | 35.93 | 10.15 | 125 | 120883 | 130455 | 64247269 |
Homicidal ideation | 35.75 | 10.15 | 37 | 120971 | 3220 | 64374504 |
Hyperhidrosis | 35.71 | 10.15 | 375 | 120633 | 124545 | 64253179 |
Initial insomnia | 35.59 | 10.15 | 49 | 120959 | 5755 | 64371969 |
Osteosclerosis | 35.41 | 10.15 | 38 | 120970 | 3448 | 64374276 |
Multiple sclerosis relapse | 35.33 | 10.15 | 162 | 120846 | 40973 | 64336751 |
Drug withdrawal syndrome | 35.32 | 10.15 | 134 | 120874 | 31157 | 64346567 |
Multiple organ dysfunction syndrome | 35.23 | 10.15 | 87 | 120921 | 101326 | 64276398 |
International normalised ratio increased | 35.09 | 10.15 | 59 | 120949 | 79108 | 64298616 |
Parkinsonism | 35.07 | 10.15 | 81 | 120927 | 14292 | 64363432 |
Loss of personal independence in daily activities | 34.72 | 10.15 | 244 | 120764 | 72210 | 64305514 |
Lower respiratory tract infection | 33.79 | 10.15 | 80 | 120928 | 94534 | 64283190 |
Muscle injury | 33.14 | 10.15 | 5 | 121003 | 26432 | 64351292 |
Pneumocystis jirovecii pneumonia | 32.92 | 10.15 | 6 | 121002 | 27628 | 64350096 |
Liver disorder | 32.78 | 10.15 | 31 | 120977 | 53320 | 64324404 |
Headache | 32.78 | 10.15 | 1258 | 119750 | 528209 | 63849515 |
Delirium | 32.56 | 10.15 | 232 | 120776 | 68962 | 64308762 |
Asthma | 32.16 | 10.15 | 296 | 120712 | 94929 | 64282795 |
Stomatitis | 32.16 | 10.15 | 102 | 120906 | 109503 | 64268221 |
Confusional state | 32.02 | 10.15 | 677 | 120331 | 260467 | 64117257 |
Hepatic failure | 31.96 | 10.15 | 34 | 120974 | 55360 | 64322364 |
Sinus bradycardia | 31.83 | 10.15 | 105 | 120903 | 22788 | 64354936 |
Vasoplegia syndrome | 31.40 | 10.15 | 32 | 120976 | 2735 | 64374989 |
Blepharospasm | 31.18 | 10.15 | 35 | 120973 | 3340 | 64374384 |
Somatic delusion | 30.68 | 10.15 | 18 | 120990 | 672 | 64377052 |
Libido increased | 30.57 | 10.15 | 26 | 120982 | 1764 | 64375960 |
Pleurothotonus | 30.55 | 10.15 | 29 | 120979 | 2273 | 64375451 |
Drug reaction with eosinophilia and systemic symptoms | 30.48 | 10.15 | 34 | 120974 | 54183 | 64323541 |
Mental disorder | 30.47 | 10.15 | 114 | 120894 | 26331 | 64351393 |
Toxic epidermal necrolysis | 30.19 | 10.15 | 16 | 120992 | 37150 | 64340574 |
Nervousness | 29.67 | 10.15 | 122 | 120886 | 29434 | 64348290 |
Anaphylactic shock | 29.52 | 10.15 | 10 | 120998 | 30318 | 64347406 |
Analgesic drug level above therapeutic | 29.52 | 10.15 | 15 | 120993 | 419 | 64377305 |
Restlessness | 29.36 | 10.15 | 150 | 120858 | 39635 | 64338089 |
Nephrectomy | 29.22 | 10.15 | 23 | 120985 | 1399 | 64376325 |
Antidepressant drug level above therapeutic | 28.84 | 10.15 | 16 | 120992 | 536 | 64377188 |
Arthropathy | 28.65 | 10.15 | 123 | 120885 | 120844 | 64256880 |
Acute myeloid leukaemia | 28.63 | 10.15 | 8 | 121000 | 27455 | 64350269 |
Blister | 28.48 | 10.15 | 69 | 120939 | 80898 | 64296826 |
Tardive dyskinesia | 28.46 | 10.15 | 57 | 120951 | 9121 | 64368603 |
Hepatocellular injury | 28.12 | 10.15 | 26 | 120982 | 45209 | 64332515 |
Rash maculo-papular | 28.11 | 10.15 | 28 | 120980 | 46998 | 64330726 |
Substance abuse | 27.97 | 10.15 | 57 | 120951 | 9235 | 64368489 |
Aggression | 27.87 | 10.15 | 165 | 120843 | 46067 | 64331657 |
Aspartate aminotransferase increased | 27.64 | 10.15 | 123 | 120885 | 119665 | 64258059 |
Hospitalisation | 27.57 | 10.15 | 238 | 120770 | 74969 | 64302755 |
Periorbital swelling | 27.54 | 10.15 | 25 | 120983 | 1851 | 64375873 |
Hallucination, auditory | 27.52 | 10.15 | 82 | 120926 | 16857 | 64360867 |
Drug screen positive | 27.37 | 10.15 | 43 | 120965 | 5686 | 64372038 |
Skin lesion | 27.23 | 10.15 | 138 | 120870 | 36344 | 64341380 |
Cardiac arrest | 27.19 | 10.15 | 423 | 120585 | 153641 | 64224083 |
Abnormal behaviour | 27.11 | 10.15 | 130 | 120878 | 33492 | 64344232 |
Cognitive disorder | 26.68 | 10.15 | 186 | 120822 | 54901 | 64322823 |
Psychomotor hyperactivity | 26.43 | 10.15 | 73 | 120935 | 14378 | 64363346 |
Exostosis | 26.32 | 10.15 | 63 | 120945 | 11375 | 64366349 |
Hereditary angioedema | 25.72 | 10.15 | 34 | 120974 | 3842 | 64373882 |
Delusion of replacement | 25.67 | 10.15 | 10 | 120998 | 145 | 64377579 |
Liver function test abnormal | 25.65 | 10.15 | 45 | 120963 | 59356 | 64318368 |
Alopecia | 25.45 | 10.15 | 194 | 120814 | 165496 | 64212228 |
Gambling disorder | 25.40 | 10.15 | 24 | 120984 | 1870 | 64375854 |
Neck pain | 25.38 | 10.15 | 200 | 120808 | 61333 | 64316391 |
Dysphoria | 25.35 | 10.15 | 36 | 120972 | 4352 | 64373372 |
Contraindicated product administered | 25.32 | 10.15 | 110 | 120898 | 107719 | 64270005 |
Post-traumatic neck syndrome | 25.31 | 10.15 | 24 | 120984 | 1878 | 64375846 |
Injection site reaction | 25.27 | 10.15 | 162 | 120846 | 46502 | 64331222 |
Listless | 25.21 | 10.15 | 31 | 120977 | 3259 | 64374465 |
Psychomotor retardation | 25.12 | 10.15 | 39 | 120969 | 5104 | 64372620 |
Abnormal dreams | 24.87 | 10.15 | 58 | 120950 | 10298 | 64367426 |
Disseminated intravascular coagulation | 24.73 | 10.15 | 15 | 120993 | 32333 | 64345391 |
Penile haemorrhage | 24.60 | 10.15 | 14 | 120994 | 493 | 64377231 |
Pleural effusion | 24.59 | 10.15 | 138 | 120870 | 126421 | 64251303 |
Hyperkalaemia | 24.46 | 10.15 | 102 | 120906 | 101027 | 64276697 |
Tonic clonic movements | 24.40 | 10.15 | 24 | 120984 | 1965 | 64375759 |
Solar urticaria | 24.36 | 10.15 | 8 | 121000 | 68 | 64377656 |
Rheumatoid factor positive | 24.29 | 10.15 | 18 | 120990 | 34920 | 64342804 |
Arteriosclerosis coronary artery | 24.12 | 10.15 | 74 | 120934 | 15455 | 64362269 |
C-reactive protein increased | 24.04 | 10.15 | 94 | 120914 | 94815 | 64282909 |
Sputum discoloured | 24.02 | 10.15 | 81 | 120927 | 17775 | 64359949 |
Autonomic nervous system imbalance | 24.02 | 10.15 | 34 | 120974 | 4098 | 64373626 |
Palmar-plantar erythrodysaesthesia syndrome | 24.01 | 10.15 | 12 | 120996 | 28807 | 64348917 |
Hypersensitivity | 23.99 | 10.15 | 244 | 120764 | 196208 | 64181516 |
Mood altered | 23.76 | 10.15 | 75 | 120933 | 15904 | 64361820 |
Sternal fracture | 23.72 | 10.15 | 25 | 120983 | 2222 | 64375502 |
Epistaxis | 23.72 | 10.15 | 99 | 120909 | 98032 | 64279692 |
Lung disorder | 23.58 | 10.15 | 49 | 120959 | 60651 | 64317073 |
Drug intolerance | 23.16 | 10.15 | 233 | 120775 | 187759 | 64189965 |
Soft tissue injury | 23.09 | 10.15 | 21 | 120987 | 1558 | 64376166 |
Sense of a foreshortened future | 22.95 | 10.15 | 5 | 121003 | 5 | 64377719 |
Coagulopathy | 22.78 | 10.15 | 16 | 120992 | 31904 | 64345820 |
Oedema peripheral | 22.59 | 10.15 | 269 | 120739 | 210048 | 64167676 |
Ejection fraction decreased | 22.39 | 10.15 | 13 | 120995 | 28694 | 64349030 |
Discoloured vomit | 22.25 | 10.15 | 18 | 120990 | 1139 | 64376585 |
Gastrointestinal haemorrhage | 22.21 | 10.15 | 151 | 120857 | 132161 | 64245563 |
Haematocrit decreased | 22.19 | 10.15 | 43 | 120965 | 54612 | 64323112 |
Concussion | 21.91 | 10.15 | 47 | 120961 | 7891 | 64369833 |
Deformity | 21.83 | 10.15 | 41 | 120967 | 6256 | 64371468 |
Renal impairment | 21.73 | 10.15 | 156 | 120852 | 134861 | 64242863 |
Hypertonia | 21.70 | 10.15 | 41 | 120967 | 6284 | 64371440 |
Accidental overdose | 21.68 | 10.15 | 122 | 120886 | 33435 | 64344289 |
Jaundice | 21.64 | 10.15 | 36 | 120972 | 48476 | 64329248 |
Symptom masked | 21.62 | 10.15 | 18 | 120990 | 1186 | 64376538 |
Heart rate abnormal | 21.61 | 10.15 | 36 | 120972 | 4999 | 64372725 |
Mood swings | 21.56 | 10.15 | 77 | 120931 | 17391 | 64360333 |
Encephalopathy | 21.48 | 10.15 | 186 | 120822 | 58633 | 64319091 |
Burning sensation | 21.36 | 10.15 | 163 | 120845 | 49501 | 64328223 |
Vertigo | 21.24 | 10.15 | 186 | 120822 | 58825 | 64318899 |
Neuroleptic malignant syndrome | 21.14 | 10.15 | 98 | 120910 | 24898 | 64352826 |
Meningitis streptococcal | 21.08 | 10.15 | 9 | 120999 | 167 | 64377557 |
Drug eruption | 21.04 | 10.15 | 22 | 120986 | 36114 | 64341610 |
Feeling abnormal | 21.03 | 10.15 | 360 | 120648 | 133242 | 64244482 |
Dry mouth | 21.00 | 10.15 | 189 | 120819 | 60229 | 64317495 |
Restrictive pulmonary disease | 20.88 | 10.15 | 23 | 120985 | 2149 | 64375575 |
Death | 20.86 | 10.15 | 1106 | 119902 | 481599 | 63896125 |
Depressed mood | 20.76 | 10.15 | 140 | 120868 | 40872 | 64336852 |
Economic problem | 20.75 | 10.15 | 23 | 120985 | 2164 | 64375560 |
Cerebral infarction | 20.69 | 10.15 | 28 | 120980 | 41016 | 64336708 |
Eye haematoma | 20.66 | 10.15 | 8 | 121000 | 114 | 64377610 |
Loss of libido | 20.63 | 10.15 | 24 | 120984 | 2380 | 64375344 |
Middle insomnia | 20.60 | 10.15 | 62 | 120946 | 12815 | 64364909 |
Haemophagocytic lymphohistiocytosis | 20.60 | 10.15 | 4 | 121004 | 17605 | 64360119 |
Body tinea | 20.50 | 10.15 | 18 | 120990 | 1275 | 64376449 |
Homicide | 20.24 | 10.15 | 17 | 120991 | 1134 | 64376590 |
Myoclonus | 20.16 | 10.15 | 97 | 120911 | 25021 | 64352703 |
Polymerase chain reaction | 20.11 | 10.15 | 8 | 121000 | 123 | 64377601 |
Apallic syndrome | 20.08 | 10.15 | 15 | 120993 | 844 | 64376880 |
Infection | 20.03 | 10.15 | 236 | 120772 | 184644 | 64193080 |
Gamma-glutamyltransferase increased | 19.83 | 10.15 | 38 | 120970 | 48472 | 64329252 |
Urticaria | 19.67 | 10.15 | 179 | 120829 | 147138 | 64230586 |
Post-traumatic stress disorder | 19.32 | 10.15 | 31 | 120977 | 4174 | 64373550 |
Angioedema | 19.23 | 10.15 | 56 | 120952 | 61765 | 64315959 |
Sensation of foreign body | 19.18 | 10.15 | 32 | 120976 | 4450 | 64373274 |
Bronchopulmonary aspergillosis | 19.09 | 10.15 | 6 | 121002 | 19079 | 64358645 |
Atrial fibrillation | 19.08 | 10.15 | 217 | 120791 | 170872 | 64206852 |
Dehydration | 19.01 | 10.15 | 289 | 120719 | 216474 | 64161250 |
Sleep disorder due to general medical condition, insomnia type | 18.97 | 10.15 | 13 | 120995 | 26257 | 64351467 |
Anticholinergic syndrome | 18.62 | 10.15 | 24 | 120984 | 2645 | 64375079 |
Aspergillus infection | 18.58 | 10.15 | 4 | 121004 | 16375 | 64361349 |
Disorganised speech | 18.57 | 10.15 | 19 | 120989 | 1631 | 64376093 |
Blood urea increased | 18.57 | 10.15 | 34 | 120974 | 44119 | 64333605 |
Psychomotor skills impaired | 18.56 | 10.15 | 29 | 120979 | 3816 | 64373908 |
Generalised oedema | 18.43 | 10.15 | 8 | 121000 | 20845 | 64356879 |
Painful erection | 18.42 | 10.15 | 8 | 121000 | 155 | 64377569 |
Irritable bowel syndrome | 18.33 | 10.15 | 26 | 120982 | 37343 | 64340381 |
Myelosuppression | 18.29 | 10.15 | 11 | 120997 | 23819 | 64353905 |
Food aversion | 18.15 | 10.15 | 13 | 120995 | 685 | 64377039 |
Abdominal discomfort | 18.14 | 10.15 | 237 | 120771 | 182085 | 64195639 |
Bronchospasm | 18.11 | 10.15 | 9 | 120999 | 21673 | 64356051 |
Ascites | 17.97 | 10.15 | 58 | 120950 | 61943 | 64315781 |
Muscle twitching | 17.96 | 10.15 | 77 | 120931 | 18921 | 64358803 |
Neuropathy peripheral | 17.85 | 10.15 | 138 | 120870 | 117387 | 64260337 |
Dissociation | 17.84 | 10.15 | 25 | 120983 | 2986 | 64374738 |
Blood potassium increased | 17.82 | 10.15 | 96 | 120912 | 25884 | 64351840 |
Unresponsive to stimuli | 17.70 | 10.15 | 158 | 120850 | 50235 | 64327489 |
Erection increased | 17.57 | 10.15 | 10 | 120998 | 352 | 64377372 |
Purple glove syndrome | 17.40 | 10.15 | 9 | 120999 | 261 | 64377463 |
Therapeutic product effect decreased | 17.26 | 10.15 | 136 | 120872 | 115215 | 64262509 |
Dementia | 17.25 | 10.15 | 81 | 120927 | 20685 | 64357039 |
Product administered at inappropriate site | 17.21 | 10.15 | 25 | 120983 | 3085 | 64374639 |
Thrombotic microangiopathy | 17.09 | 10.15 | 5 | 121003 | 16650 | 64361074 |
Posterior reversible encephalopathy syndrome | 17.05 | 10.15 | 11 | 120997 | 22935 | 64354789 |
Myelodysplastic syndrome | 16.97 | 10.15 | 16 | 120992 | 27563 | 64350161 |
Wound infection fungal | 16.93 | 10.15 | 8 | 121000 | 190 | 64377534 |
Brain injury | 16.91 | 10.15 | 49 | 120959 | 9916 | 64367808 |
Major depression | 16.86 | 10.15 | 42 | 120966 | 7774 | 64369950 |
Dyskinesia | 16.78 | 10.15 | 129 | 120879 | 39259 | 64338465 |
Personality disorder | 16.74 | 10.15 | 31 | 120977 | 4680 | 64373044 |
Skin texture abnormal | 16.72 | 10.15 | 10 | 120998 | 387 | 64377337 |
Aplastic anaemia | 16.63 | 10.15 | 3 | 121005 | 13917 | 64363807 |
Distributive shock | 16.56 | 10.15 | 19 | 120989 | 1856 | 64375868 |
Product packaging difficult to open | 16.46 | 10.15 | 5 | 121003 | 32 | 64377692 |
Cardiomyopathy | 16.45 | 10.15 | 14 | 120994 | 25342 | 64352382 |
Bipolar disorder | 16.38 | 10.15 | 38 | 120970 | 6723 | 64371001 |
Hypokinesia | 16.26 | 10.15 | 68 | 120940 | 16528 | 64361196 |
Blood lactate dehydrogenase increased | 16.24 | 10.15 | 23 | 120985 | 33055 | 64344669 |
Injection site induration | 16.21 | 10.15 | 45 | 120963 | 8887 | 64368837 |
Heterophoria | 16.20 | 10.15 | 5 | 121003 | 34 | 64377690 |
Neutropenic sepsis | 16.17 | 10.15 | 12 | 120996 | 23260 | 64354464 |
Apathy | 16.05 | 10.15 | 52 | 120956 | 11180 | 64366544 |
Paranoia | 16.02 | 10.15 | 67 | 120941 | 16285 | 64361439 |
Procedural failure | 15.86 | 10.15 | 6 | 121002 | 80 | 64377644 |
Obsessive thoughts | 15.81 | 10.15 | 14 | 120994 | 1003 | 64376721 |
Eczema eyelids | 15.78 | 10.15 | 7 | 121001 | 143 | 64377581 |
White blood cell count decreased | 15.77 | 10.15 | 205 | 120803 | 157632 | 64220092 |
Inflammation | 15.70 | 10.15 | 66 | 120942 | 65234 | 64312490 |
Body height decreased | 15.68 | 10.15 | 40 | 120968 | 7514 | 64370210 |
Pruritus genital | 15.63 | 10.15 | 14 | 120994 | 1018 | 64376706 |
Blood calcium decreased | 15.52 | 10.15 | 15 | 120993 | 25539 | 64352185 |
Lack of injection site rotation | 15.39 | 10.15 | 9 | 120999 | 334 | 64377390 |
Deep vein thrombosis | 15.28 | 10.15 | 125 | 120883 | 105057 | 64272667 |
Disorientation | 15.20 | 10.15 | 166 | 120842 | 55662 | 64322062 |
Compulsive sexual behaviour | 15.16 | 10.15 | 8 | 121000 | 242 | 64377482 |
Sleep deficit | 15.09 | 10.15 | 13 | 120995 | 898 | 64376826 |
Therapy non-responder | 15.00 | 10.15 | 68 | 120940 | 65831 | 64311893 |
Haematotoxicity | 14.93 | 10.15 | 3 | 121005 | 12893 | 64364831 |
Acute myopia | 14.86 | 10.15 | 6 | 121002 | 96 | 64377628 |
Euphoric mood | 14.84 | 10.15 | 36 | 120972 | 6555 | 64371169 |
Burning mouth syndrome | 14.71 | 10.15 | 10 | 120998 | 484 | 64377240 |
Taste disorder | 14.70 | 10.15 | 45 | 120963 | 9388 | 64368336 |
Hypotension | 14.69 | 10.15 | 864 | 120144 | 380110 | 63997614 |
Hallucination, visual | 14.68 | 10.15 | 96 | 120912 | 27738 | 64349986 |
Perseveration | 14.49 | 10.15 | 9 | 120999 | 373 | 64377351 |
Hanging | 14.48 | 10.15 | 6 | 121002 | 103 | 64377621 |
Total lung capacity decreased | 14.46 | 10.15 | 17 | 120991 | 1705 | 64376019 |
Haemolytic anaemia | 14.44 | 10.15 | 6 | 121002 | 16047 | 64361677 |
Catatonia | 14.44 | 10.15 | 39 | 120969 | 7581 | 64370143 |
Neuropsychiatric symptoms | 14.43 | 10.15 | 13 | 120995 | 953 | 64376771 |
Accommodation disorder | 14.32 | 10.15 | 10 | 120998 | 506 | 64377218 |
Osteonecrosis of jaw | 13.95 | 10.15 | 34 | 120974 | 39791 | 64337933 |
Pancreatitis acute | 13.93 | 10.15 | 38 | 120970 | 42817 | 64334907 |
Homeless | 13.92 | 10.15 | 6 | 121002 | 114 | 64377610 |
Thyroglobulin increased | 13.92 | 10.15 | 5 | 121003 | 57 | 64377667 |
Erythema | 13.92 | 10.15 | 257 | 120751 | 186813 | 64190911 |
Abortion spontaneous | 13.88 | 10.15 | 16 | 120992 | 25127 | 64352597 |
Accidental death | 13.86 | 10.15 | 25 | 120983 | 3700 | 64374024 |
Alcohol withdrawal syndrome | 13.83 | 10.15 | 17 | 120991 | 1786 | 64375938 |
Galactorrhoea | 13.80 | 10.15 | 23 | 120985 | 3196 | 64374528 |
Respiratory distress | 13.79 | 10.15 | 51 | 120957 | 52280 | 64325444 |
Urine odour abnormal | 13.71 | 10.15 | 30 | 120978 | 5106 | 64372618 |
Premature delivery | 13.69 | 10.15 | 9 | 120999 | 18580 | 64359144 |
Klebsiella infection | 13.60 | 10.15 | 4 | 121004 | 13277 | 64364447 |
Drug use disorder | 13.56 | 10.15 | 33 | 120975 | 6021 | 64371703 |
Blood prolactin increased | 13.54 | 10.15 | 24 | 120984 | 3504 | 64374220 |
Neutrophil count decreased | 13.50 | 10.15 | 87 | 120921 | 77109 | 64300615 |
Needle issue | 13.31 | 10.15 | 43 | 120965 | 9229 | 64368495 |
Tuberculosis | 13.22 | 10.15 | 4 | 121004 | 13034 | 64364690 |
Red blood cell sedimentation rate increased | 13.18 | 10.15 | 24 | 120984 | 31211 | 64346513 |
Knee deformity | 13.13 | 10.15 | 12 | 120996 | 896 | 64376828 |
Delirium febrile | 13.13 | 10.15 | 5 | 121003 | 68 | 64377656 |
Genital infection female | 13.13 | 10.15 | 5 | 121003 | 68 | 64377656 |
Tongue discolouration | 13.04 | 10.15 | 23 | 120985 | 3345 | 64374379 |
Nausea | 13.00 | 10.15 | 1673 | 119335 | 784127 | 63593597 |
Holmes-Adie pupil | 12.98 | 10.15 | 4 | 121004 | 27 | 64377697 |
Plasma cell mastitis | 12.98 | 10.15 | 4 | 121004 | 27 | 64377697 |
Mydriasis | 12.92 | 10.15 | 60 | 120948 | 15252 | 64362472 |
Blood cholinesterase decreased | 12.85 | 10.15 | 7 | 121001 | 226 | 64377498 |
Affective disorder | 12.79 | 10.15 | 34 | 120974 | 6546 | 64371178 |
Compartment syndrome | 12.78 | 10.15 | 26 | 120982 | 4206 | 64373518 |
Foaming at mouth | 12.78 | 10.15 | 16 | 120992 | 1713 | 64376011 |
Basal cell carcinoma | 12.74 | 10.15 | 24 | 120984 | 30814 | 64346910 |
Pseudomonas infection | 12.71 | 10.15 | 9 | 120999 | 17874 | 64359850 |
Compulsive shopping | 12.69 | 10.15 | 11 | 120997 | 766 | 64376958 |
Anorgasmia | 12.68 | 10.15 | 12 | 120996 | 937 | 64376787 |
Infusion site urticaria | 12.66 | 10.15 | 10 | 120998 | 611 | 64377113 |
Delusion | 12.65 | 10.15 | 67 | 120941 | 17947 | 64359777 |
Thinking abnormal | 12.64 | 10.15 | 49 | 120959 | 11507 | 64366217 |
Pericardial effusion | 12.62 | 10.15 | 35 | 120973 | 39219 | 64338505 |
Neurotoxicity | 12.53 | 10.15 | 20 | 120988 | 27384 | 64350340 |
Torsade de pointes | 12.48 | 10.15 | 65 | 120943 | 17298 | 64360426 |
Dyspnoea exertional | 12.44 | 10.15 | 84 | 120924 | 73646 | 64304078 |
Balance disorder | 12.43 | 10.15 | 224 | 120784 | 83702 | 64294022 |
Wrong patient received product | 12.43 | 10.15 | 24 | 120984 | 3738 | 64373986 |
Skin sensitisation | 12.41 | 10.15 | 11 | 120997 | 789 | 64376935 |
Epstein-Barr virus infection | 12.36 | 10.15 | 4 | 121004 | 12484 | 64365240 |
Coma | 12.34 | 10.15 | 232 | 120776 | 87383 | 64290341 |
Substance use disorder | 12.31 | 10.15 | 8 | 121000 | 359 | 64377365 |
Hepatitis | 12.29 | 10.15 | 44 | 120964 | 45538 | 64332186 |
Screaming | 12.26 | 10.15 | 23 | 120985 | 3506 | 64374218 |
Obsessive rumination | 12.24 | 10.15 | 3 | 121005 | 7 | 64377717 |
Slow speech | 12.20 | 10.15 | 17 | 120991 | 2020 | 64375704 |
Toxic skin eruption | 12.09 | 10.15 | 11 | 120997 | 19273 | 64358451 |
Transplant rejection | 12.05 | 10.15 | 9 | 120999 | 17392 | 64360332 |
Proteinuria | 11.97 | 10.15 | 21 | 120987 | 27702 | 64350022 |
Ejection fraction abnormal | 11.95 | 10.15 | 14 | 120994 | 1399 | 64376325 |
Feeling of despair | 11.89 | 10.15 | 19 | 120989 | 2549 | 64375175 |
Persistent depressive disorder | 11.89 | 10.15 | 12 | 120996 | 1014 | 64376710 |
Toxicologic test abnormal | 11.83 | 10.15 | 13 | 120995 | 1212 | 64376512 |
Peritoneal perforation | 11.73 | 10.15 | 6 | 121002 | 170 | 64377554 |
Personal relationship issue | 11.63 | 10.15 | 6 | 121002 | 173 | 64377551 |
Mental impairment | 11.63 | 10.15 | 61 | 120947 | 16282 | 64361442 |
Heat stroke | 11.62 | 10.15 | 14 | 120994 | 1441 | 64376283 |
Haemodialysis | 11.61 | 10.15 | 9 | 120999 | 17068 | 64360656 |
Haematemesis | 11.61 | 10.15 | 47 | 120961 | 46952 | 64330772 |
Drug screen negative | 11.61 | 10.15 | 7 | 121001 | 275 | 64377449 |
Obsessive-compulsive disorder | 11.59 | 10.15 | 27 | 120981 | 4791 | 64372933 |
Hangover | 11.58 | 10.15 | 16 | 120992 | 1885 | 64375839 |
Ill-defined disorder | 11.56 | 10.15 | 43 | 120965 | 44009 | 64333715 |
Product complaint | 11.53 | 10.15 | 4 | 121004 | 11950 | 64365774 |
Nodule | 11.53 | 10.15 | 10 | 120998 | 17937 | 64359787 |
Breast disorder | 11.53 | 10.15 | 15 | 120993 | 1669 | 64376055 |
Bacterial vaginosis | 11.50 | 10.15 | 11 | 120997 | 870 | 64376854 |
Somnambulism | 11.49 | 10.15 | 28 | 120980 | 5113 | 64372611 |
Eosinophilia | 11.47 | 10.15 | 35 | 120973 | 38041 | 64339683 |
Cholecystitis | 11.38 | 10.15 | 12 | 120996 | 19624 | 64358100 |
Discomfort | 11.35 | 10.15 | 97 | 120911 | 80781 | 64296943 |
Morbid thoughts | 11.30 | 10.15 | 10 | 120998 | 716 | 64377008 |
Wandering pacemaker | 11.24 | 10.15 | 3 | 121005 | 11 | 64377713 |
Bite | 11.19 | 10.15 | 8 | 121000 | 420 | 64377304 |
Impaired quality of life | 11.16 | 10.15 | 32 | 120976 | 6439 | 64371285 |
Tumour lysis syndrome | 11.14 | 10.15 | 12 | 120996 | 19428 | 64358296 |
Shock | 11.01 | 10.15 | 115 | 120893 | 38125 | 64339599 |
Bradycardia | 10.96 | 10.15 | 295 | 120713 | 117924 | 64259800 |
Alcohol interaction | 10.95 | 10.15 | 25 | 120983 | 4376 | 64373348 |
Device related infection | 10.85 | 10.15 | 26 | 120982 | 30600 | 64347124 |
Psoriasis | 10.84 | 10.15 | 192 | 120816 | 71511 | 64306213 |
Dermatitis exfoliative | 10.82 | 10.15 | 3 | 121005 | 10349 | 64367375 |
White blood cell count increased | 10.75 | 10.15 | 76 | 120932 | 65938 | 64311786 |
Hypogammaglobulinaemia | 10.74 | 10.15 | 3 | 121005 | 10296 | 64367428 |
Expired product administered | 10.71 | 10.15 | 30 | 120978 | 5957 | 64371767 |
Ventricular tachycardia | 10.68 | 10.15 | 31 | 120977 | 34234 | 64343490 |
Device malfunction | 10.67 | 10.15 | 63 | 120945 | 17570 | 64360154 |
Renal injury | 10.66 | 10.15 | 8 | 121000 | 15421 | 64362303 |
Periorbital haemorrhage | 10.65 | 10.15 | 6 | 121002 | 207 | 64377517 |
Joint effusion | 10.65 | 10.15 | 6 | 121002 | 13467 | 64364257 |
Immobile | 10.62 | 10.15 | 30 | 120978 | 5985 | 64371739 |
Affect lability | 10.56 | 10.15 | 39 | 120969 | 8951 | 64368773 |
Second primary malignancy | 10.49 | 10.15 | 5 | 121003 | 12332 | 64365392 |
Metastases to liver | 10.46 | 10.15 | 18 | 120990 | 23923 | 64353801 |
Bronchopulmonary aspergillosis allergic | 10.41 | 10.15 | 14 | 120994 | 1608 | 64376116 |
Alcohol poisoning | 10.40 | 10.15 | 24 | 120984 | 4231 | 64373493 |
Antipsychotic drug level above therapeutic | 10.36 | 10.15 | 15 | 120993 | 1846 | 64375878 |
Extra dose administered | 10.33 | 10.15 | 32 | 120976 | 6718 | 64371006 |
Hip arthroplasty | 10.33 | 10.15 | 15 | 120993 | 21336 | 64356388 |
Ileus | 10.28 | 10.15 | 17 | 120991 | 22949 | 64354775 |
Myotonia | 10.27 | 10.15 | 6 | 121002 | 222 | 64377502 |
Dermatitis allergic | 10.23 | 10.15 | 8 | 121000 | 15101 | 64362623 |
Impaired gastric emptying | 10.18 | 10.15 | 38 | 120970 | 8766 | 64368958 |
Transaminases increased | 10.15 | 10.15 | 46 | 120962 | 44548 | 64333176 |
Haematuria | 10.15 | 10.15 | 69 | 120939 | 60402 | 64317322 |
None
Source | Code | Description |
---|---|---|
ATC | N06AX05 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Other antidepressants |
MeSH PA | D014151 | Anti-Anxiety Agents |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D018687 | Antidepressive Agents, Second-Generation |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D018490 | Serotonin Agents |
MeSH PA | D017367 | Serotonin Uptake Inhibitors |
MeSH PA | D014149 | Tranquilizing Agents |
CHEBI has role | CHEBI:35469 | antidepressants |
CHEBI has role | CHEBI:35474 | anti-anxiety agents |
CHEBI has role | CHEBI:35717 | hypnotics |
CHEBI has role | CHEBI:37887 | adrenergic blockers |
CHEBI has role | CHEBI:37955 | H1 receptor antagonists |
CHEBI has role | CHEBI:50949 | SSRI |
FDA EPC | N0000175696 | Serotonin Reuptake Inhibitor |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Major depressive disorder | indication | 370143000 | |
Insomnia | off-label use | 193462001 | |
Priapism | contraindication | 6273006 | DOID:9286 |
Suicidal thoughts | contraindication | 6471006 | |
Orthostatic hypotension | contraindication | 28651003 | |
Torsades de pointes | contraindication | 31722008 | |
Hypokalemia | contraindication | 43339004 | |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Heart disease | contraindication | 56265001 | DOID:114 |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Prolonged QT interval | contraindication | 111975006 | |
Hypomagnesemia | contraindication | 190855004 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Myocardial infarction in recovery phase | contraindication | 418044006 | |
Congenital long QT syndrome | contraindication | 442917000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 6.98 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
150MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | OLEPTRO | ANGELINI PHARMA | N022411 | Feb. 2, 2010 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 7829120 | March 27, 2027 | METHOD OF TREATING DEPRESSION |
300MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | OLEPTRO | ANGELINI PHARMA | N022411 | Feb. 2, 2010 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 7829120 | March 27, 2027 | METHOD OF TREATING DEPRESSION |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 2A | GPCR | ANTAGONIST | Ki | 7.35 | WOMBAT-PK | CHEMBL | |||
5-hydroxytryptamine receptor 2C | GPCR | ANTAGONIST | Ki | 6.65 | WOMBAT-PK | CHEMBL | |||
Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Kd | 6.80 | WOMBAT-PK | CHEMBL | |||
Alpha-2A adrenergic receptor | GPCR | Ki | 6.58 | WOMBAT-PK | |||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.03 | DRUG MATRIX | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.54 | WOMBAT-PK | |||||
Sodium-dependent noradrenaline transporter | Transporter | Kd | 5.07 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 7.02 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 7 | GPCR | Ki | 5.75 | PDSP | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 9.55 | WOMBAT-PK | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 6.75 | DRUG MATRIX | |||||
D(3) dopamine receptor | GPCR | Ki | 5.90 | DRUG MATRIX | |||||
Histamine H1 receptor | GPCR | Ki | 6.21 | WOMBAT-PK | |||||
Histamine H2 receptor | GPCR | Ki | 5.48 | PDSP | |||||
5-hydroxytryptamine receptor 1D | GPCR | Ki | 6.98 | PDSP | |||||
Alpha-2C adrenergic receptor | GPCR | Ki | 6.81 | PDSP | |||||
Sodium-dependent dopamine transporter | Transporter | Kd | 5.13 | WOMBAT-PK | |||||
D(4) dopamine receptor | GPCR | Ki | 6.15 | PDSP | |||||
Alpha-1D adrenergic receptor | GPCR | Ki | 7.33 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 7.08 | WOMBAT-PK | |||||
HLA class I histocompatibility antigen, A-3 alpha chain | Unclassified | Kd | 5.60 | CHEMBL | |||||
D(1A) dopamine receptor | GPCR | Ki | 5.43 | PDSP | |||||
D(2) dopamine receptor | GPCR | Ki | 5.46 | PDSP | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 7.22 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 1B | GPCR | Ki | 6.08 | DRUG MATRIX | |||||
Membrane-associated progesterone receptor component 1 | Membrane receptor | Ki | 6.08 | DRUG MATRIX | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 6.93 | CHEMBL | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 6.65 | CHEMBL | |||||
5-hydroxytryptamine receptor 2A | GPCR | IC50 | 7.77 | CHEMBL | |||||
5-hydroxytryptamine receptor 2C | GPCR | ANTAGONIST | Ki | 6.70 | IUPHAR |
ID | Source |
---|---|
4019954 | VUID |
N0000148039 | NUI |
D00820 | KEGG_DRUG |
25332-39-2 | SECONDARY_CAS_RN |
4018812 | VANDF |
4019954 | VANDF |
C0040805 | UMLSCUI |
CHEBI:9654 | CHEBI |
CHEMBL621 | ChEMBL_ID |
DB00656 | DRUGBANK_ID |
CHEMBL1200798 | ChEMBL_ID |
D014196 | MESH_DESCRIPTOR_UI |
5533 | PUBCHEM_CID |
213 | IUPHAR_LIGAND_ID |
2878 | INN_ID |
YBK48BXK30 | UNII |
10737 | RXNORM |
1504 | MMSL |
5609 | MMSL |
d00395 | MMSL |
001511 | NDDF |
004610 | NDDF |
372829000 | SNOMEDCT_US |
58956008 | SNOMEDCT_US |
7336002 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0711 | TABLET | 300 mg | ORAL | ANDA | 26 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0733 | TABLET | 300 mg | ORAL | ANDA | 26 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-2578 | TABLET | 50 mg | ORAL | ANDA | 31 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-2579 | TABLET | 100 mg | ORAL | ANDA | 31 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8339 | TABLET | 150 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8371 | TABLET | 50 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8386 | TABLET | 100 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8386 | TABLET | 100 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6554 | TABLET | 50 mg | ORAL | ANDA | 21 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6555 | TABLET | 100 mg | ORAL | ANDA | 21 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6868 | TABLET | 50 mg | ORAL | ANDA | 27 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6868 | TABLET | 50 mg | ORAL | ANDA | 27 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6869 | TABLET | 100 mg | ORAL | ANDA | 27 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6869 | TABLET | 100 mg | ORAL | ANDA | 27 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7212 | TABLET | 150 mg | ORAL | ANDA | 27 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-532 | TABLET | 100 mg | ORAL | ANDA | 31 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-533 | TABLET | 150 mg | ORAL | ANDA | 24 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-534 | TABLET | 50 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-867 | TABLET | 150 mg | ORAL | ANDA | 21 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-193 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 31 sections |
Trazodone Hydrochloride | Human Prescription Drug Label | 1 | 13107-079 | TABLET | 50 mg | ORAL | ANDA | 29 sections |
Trazodone Hydrochloride | Human Prescription Drug Label | 1 | 13107-080 | TABLET | 100 mg | ORAL | ANDA | 29 sections |
Trazodone Hydrochloride | Human Prescription Drug Label | 1 | 13107-081 | TABLET | 150 mg | ORAL | ANDA | 29 sections |
Trazodone Hydrochloride | Human Prescription Drug Label | 1 | 13107-082 | TABLET | 300 mg | ORAL | ANDA | 29 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-330 | TABLET | 50 mg | ORAL | ANDA | 22 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-331 | TABLET | 100 mg | ORAL | ANDA | 22 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-332 | TABLET | 150 mg | ORAL | ANDA | 22 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-333 | TABLET | 300 mg | ORAL | ANDA | 22 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-231 | TABLET | 50 mg | ORAL | ANDA | 25 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-232 | TABLET | 100 mg | ORAL | ANDA | 25 sections |