Stem definition | Drug id | CAS RN |
---|---|---|
2717 | 19794-93-5 |
Dose | Unit | Route |
---|---|---|
0.30 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.20 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 23.05 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 81 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.52 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 1.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.08 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 7.30 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 24, 1981 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1256.40 | 10.08 | 1465 | 119419 | 144208 | 63223930 |
Drug abuse | 549.82 | 10.08 | 684 | 120200 | 71834 | 63296304 |
Sopor | 500.02 | 10.08 | 381 | 120503 | 21783 | 63346355 |
Toxicity to various agents | 440.04 | 10.08 | 1246 | 119638 | 246004 | 63122134 |
Serotonin syndrome | 377.69 | 10.08 | 362 | 120522 | 28320 | 63339818 |
Pemphigus | 328.43 | 10.08 | 4 | 120880 | 183722 | 63184416 |
Polycystic ovaries | 294.71 | 10.08 | 152 | 120732 | 4319 | 63363819 |
Hand deformity | 270.58 | 10.08 | 7 | 120877 | 159450 | 63208688 |
Systemic lupus erythematosus | 248.78 | 10.08 | 48 | 120836 | 208870 | 63159268 |
Sensitisation | 243.23 | 10.08 | 122 | 120762 | 3264 | 63364874 |
Suicide attempt | 229.12 | 10.08 | 414 | 120470 | 60504 | 63307634 |
Rhinitis allergic | 218.11 | 10.08 | 180 | 120704 | 11547 | 63356591 |
Pericarditis | 215.22 | 10.08 | 8 | 120876 | 131571 | 63236567 |
Glossodynia | 211.05 | 10.08 | 42 | 120842 | 178834 | 63189304 |
Anti-cyclic citrullinated peptide antibody positive | 205.56 | 10.08 | 3 | 120881 | 116209 | 63251929 |
Maternal exposure during pregnancy | 205.36 | 10.08 | 81 | 120803 | 219981 | 63148157 |
Swelling | 200.07 | 10.08 | 140 | 120744 | 275238 | 63092900 |
Ejection fraction | 197.65 | 10.08 | 95 | 120789 | 2311 | 63365827 |
Wound | 193.30 | 10.08 | 38 | 120846 | 163225 | 63204913 |
Sleep disorder due to a general medical condition | 191.83 | 10.08 | 170 | 120714 | 12018 | 63356120 |
Gastrooesophageal reflux disease | 189.58 | 10.08 | 502 | 120382 | 95137 | 63273001 |
Blood test abnormal | 188.41 | 10.08 | 188 | 120696 | 15441 | 63352697 |
Hypomania | 179.49 | 10.08 | 125 | 120759 | 6205 | 63361933 |
Suicidal ideation | 168.16 | 10.08 | 369 | 120515 | 62052 | 63306086 |
Cardio-respiratory arrest | 163.29 | 10.08 | 356 | 120528 | 59603 | 63308535 |
Sleep apnoea syndrome | 154.14 | 10.08 | 231 | 120653 | 28902 | 63339236 |
Schizophrenia | 153.03 | 10.08 | 137 | 120747 | 9815 | 63358323 |
Synovitis | 146.64 | 10.08 | 87 | 120797 | 186831 | 63181307 |
Contraindicated product administered | 142.35 | 10.08 | 123 | 120761 | 217525 | 63150613 |
Helicobacter infection | 140.99 | 10.08 | 9 | 120875 | 92776 | 63275362 |
Exposure during pregnancy | 134.34 | 10.08 | 64 | 120820 | 155483 | 63212655 |
Alopecia | 133.95 | 10.08 | 276 | 120608 | 337260 | 63030878 |
Jaundice cholestatic | 133.24 | 10.08 | 111 | 120773 | 7213 | 63360925 |
Abdominal discomfort | 129.35 | 10.08 | 260 | 120624 | 320625 | 63047513 |
Product dose omission issue | 127.68 | 10.08 | 823 | 120061 | 233490 | 63134648 |
Drug interaction | 127.44 | 10.08 | 809 | 120075 | 228322 | 63139816 |
Overdose | 124.59 | 10.08 | 491 | 120393 | 114587 | 63253551 |
Presbyacusis | 121.83 | 10.08 | 73 | 120811 | 2792 | 63365346 |
Joint swelling | 119.24 | 10.08 | 281 | 120603 | 327385 | 63040753 |
Infusion related reaction | 116.99 | 10.08 | 179 | 120705 | 245342 | 63122796 |
Carpal tunnel syndrome | 114.34 | 10.08 | 168 | 120716 | 20649 | 63347489 |
Folliculitis | 112.52 | 10.08 | 5 | 120879 | 70312 | 63297826 |
Impaired healing | 111.06 | 10.08 | 29 | 120855 | 102513 | 63265625 |
Pleural fibrosis | 108.96 | 10.08 | 73 | 120811 | 3399 | 63364739 |
Psychotic disorder | 107.33 | 10.08 | 183 | 120701 | 25529 | 63342609 |
Arthropathy | 107.29 | 10.08 | 176 | 120708 | 234616 | 63133522 |
Pleural thickening | 106.13 | 10.08 | 67 | 120817 | 2816 | 63365322 |
Rash | 103.60 | 10.08 | 635 | 120249 | 560236 | 62807902 |
Muscle injury | 103.41 | 10.08 | 5 | 120879 | 65340 | 63302798 |
Blood magnesium increased | 102.92 | 10.08 | 67 | 120817 | 2971 | 63365167 |
Lung diffusion test abnormal | 101.04 | 10.08 | 34 | 120850 | 309 | 63367829 |
Migraine | 100.03 | 10.08 | 426 | 120458 | 102920 | 63265218 |
Depression | 97.24 | 10.08 | 674 | 120210 | 195818 | 63172320 |
Electrocardiogram QT prolonged | 96.85 | 10.08 | 291 | 120593 | 59239 | 63308899 |
Withdrawal syndrome | 95.17 | 10.08 | 151 | 120733 | 19846 | 63348292 |
Anxiety | 92.12 | 10.08 | 719 | 120165 | 216822 | 63151316 |
Deafness neurosensory | 87.11 | 10.08 | 73 | 120811 | 4782 | 63363356 |
Loss of personal independence in daily activities | 86.51 | 10.08 | 391 | 120493 | 96899 | 63271239 |
Asthma | 83.37 | 10.08 | 470 | 120414 | 127091 | 63241047 |
Insomnia | 83.30 | 10.08 | 697 | 120187 | 214555 | 63153583 |
Suspected suicide | 80.99 | 10.08 | 80 | 120804 | 6488 | 63361650 |
Tremor | 80.41 | 10.08 | 478 | 120406 | 131761 | 63236377 |
Ejection fraction abnormal | 79.86 | 10.08 | 47 | 120837 | 1738 | 63366400 |
Blepharospasm | 79.51 | 10.08 | 76 | 120808 | 5920 | 63362218 |
General physical health deterioration | 77.01 | 10.08 | 168 | 120716 | 201234 | 63166904 |
Memory impairment | 76.14 | 10.08 | 396 | 120488 | 103862 | 63264276 |
Discomfort | 75.92 | 10.08 | 126 | 120758 | 167248 | 63200890 |
Nephrectomy | 73.56 | 10.08 | 42 | 120842 | 1466 | 63366672 |
Neutropenia | 71.10 | 10.08 | 141 | 120743 | 174864 | 63193274 |
Drug intolerance | 70.46 | 10.08 | 325 | 120559 | 308336 | 63059802 |
Thrombocytopenia | 70.23 | 10.08 | 112 | 120772 | 151045 | 63217093 |
Hypersensitivity | 68.70 | 10.08 | 305 | 120579 | 292380 | 63075758 |
Epigastric discomfort | 68.14 | 10.08 | 74 | 120810 | 6706 | 63361432 |
Sputum discoloured | 67.76 | 10.08 | 116 | 120768 | 16231 | 63351907 |
Blister | 67.36 | 10.08 | 89 | 120795 | 129725 | 63238413 |
Neovascularisation | 67.13 | 10.08 | 36 | 120848 | 1109 | 63367029 |
Therapeutic product effect decreased | 66.78 | 10.08 | 170 | 120714 | 193017 | 63175121 |
Respiratory arrest | 66.30 | 10.08 | 173 | 120711 | 32472 | 63335666 |
Stomatitis | 65.19 | 10.08 | 102 | 120782 | 138623 | 63229515 |
Confabulation | 64.78 | 10.08 | 24 | 120860 | 296 | 63367842 |
Pyrexia | 64.09 | 10.08 | 580 | 120304 | 469898 | 62898240 |
Hyper IgE syndrome | 63.76 | 10.08 | 27 | 120857 | 483 | 63367655 |
C-reactive protein abnormal | 63.09 | 10.08 | 7 | 120877 | 46089 | 63322049 |
Myocardial stunning | 62.46 | 10.08 | 20 | 120864 | 153 | 63367985 |
Haemoglobin decreased | 61.90 | 10.08 | 114 | 120770 | 145371 | 63222767 |
Burning sensation | 61.16 | 10.08 | 235 | 120649 | 54172 | 63313966 |
Pancytopenia | 60.66 | 10.08 | 57 | 120827 | 96876 | 63271262 |
Irritability | 59.36 | 10.08 | 163 | 120721 | 31531 | 63336607 |
Intentional overdose | 57.87 | 10.08 | 287 | 120597 | 73865 | 63294273 |
Skin lesion | 57.54 | 10.08 | 158 | 120726 | 30563 | 63337575 |
Agitation | 57.54 | 10.08 | 246 | 120638 | 59511 | 63308627 |
Wheezing | 57.10 | 10.08 | 344 | 120540 | 95251 | 63272887 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 56.80 | 10.08 | 40 | 120844 | 2021 | 63366117 |
Ill-defined disorder | 54.87 | 10.08 | 45 | 120839 | 81710 | 63286428 |
Bradyphrenia | 54.69 | 10.08 | 67 | 120817 | 6913 | 63361225 |
Anaemia | 54.64 | 10.08 | 331 | 120553 | 293099 | 63075039 |
Irritable bowel syndrome | 52.11 | 10.08 | 48 | 120836 | 82364 | 63285774 |
Febrile neutropenia | 52.01 | 10.08 | 91 | 120793 | 118358 | 63249780 |
Lower respiratory tract infection | 51.69 | 10.08 | 109 | 120775 | 132198 | 63235940 |
Bone cyst | 51.37 | 10.08 | 39 | 120845 | 2215 | 63365923 |
Extrapyramidal disorder | 50.82 | 10.08 | 91 | 120793 | 13193 | 63354945 |
Poor quality sleep | 50.46 | 10.08 | 115 | 120769 | 19820 | 63348318 |
Hypothyroidism | 50.28 | 10.08 | 187 | 120697 | 42445 | 63325693 |
Taste disorder | 50.25 | 10.08 | 92 | 120792 | 13570 | 63354568 |
Paradoxical drug reaction | 50.14 | 10.08 | 50 | 120834 | 4102 | 63364036 |
Hyperreflexia | 49.83 | 10.08 | 59 | 120825 | 5875 | 63362263 |
Drug withdrawal syndrome | 49.09 | 10.08 | 138 | 120746 | 27056 | 63341082 |
Leukopenia | 48.89 | 10.08 | 45 | 120839 | 77245 | 63290893 |
Cardiac disorder | 48.77 | 10.08 | 209 | 120675 | 50607 | 63317531 |
Total lung capacity increased | 48.35 | 10.08 | 38 | 120846 | 2272 | 63365866 |
Adjustment disorder with mixed anxiety and depressed mood | 48.00 | 10.08 | 15 | 120869 | 105 | 63368033 |
Asphyxia | 47.89 | 10.08 | 59 | 120825 | 6122 | 63362016 |
Mucosal inflammation | 47.61 | 10.08 | 15 | 120869 | 46913 | 63321225 |
Visual perseveration | 45.79 | 10.08 | 13 | 120871 | 62 | 63368076 |
Cyst | 45.74 | 10.08 | 90 | 120794 | 14009 | 63354129 |
Nightmare | 45.59 | 10.08 | 108 | 120776 | 19086 | 63349052 |
Arteriosclerosis coronary artery | 45.15 | 10.08 | 67 | 120817 | 8306 | 63359832 |
Abnormal behaviour | 43.97 | 10.08 | 114 | 120770 | 21312 | 63346826 |
Malignant neoplasm progression | 43.94 | 10.08 | 55 | 120829 | 82066 | 63286072 |
Liver injury | 43.56 | 10.08 | 31 | 120853 | 60489 | 63307649 |
Accidental poisoning | 43.27 | 10.08 | 22 | 120862 | 606 | 63367532 |
Total lung capacity decreased | 41.62 | 10.08 | 34 | 120850 | 2149 | 63365989 |
Oral discomfort | 40.40 | 10.08 | 67 | 120817 | 9134 | 63359004 |
Injection site mass | 40.08 | 10.08 | 101 | 120783 | 18555 | 63349583 |
Sleep disorder due to general medical condition, insomnia type | 39.93 | 10.08 | 25 | 120859 | 52192 | 63315946 |
Rheumatoid factor positive | 39.70 | 10.08 | 62 | 120822 | 84344 | 63283794 |
Somatic delusion | 38.65 | 10.08 | 20 | 120864 | 572 | 63367566 |
Persistent genital arousal disorder | 38.63 | 10.08 | 16 | 120868 | 270 | 63367868 |
Restrictive pulmonary disease | 38.59 | 10.08 | 30 | 120854 | 1765 | 63366373 |
Obstructive airways disorder | 38.31 | 10.08 | 106 | 120778 | 20593 | 63347545 |
Disorganised speech | 38.27 | 10.08 | 26 | 120858 | 1239 | 63366899 |
Product use issue | 37.32 | 10.08 | 256 | 120628 | 220264 | 63147874 |
Body tinea | 37.29 | 10.08 | 30 | 120854 | 1855 | 63366283 |
Fall | 36.92 | 10.08 | 993 | 119891 | 391341 | 62976797 |
Somnolence | 36.80 | 10.08 | 510 | 120374 | 178175 | 63189963 |
Intentional self-injury | 36.63 | 10.08 | 120 | 120764 | 25567 | 63342571 |
Bone marrow failure | 36.40 | 10.08 | 6 | 120878 | 29284 | 63338854 |
Restless legs syndrome | 36.40 | 10.08 | 97 | 120787 | 18434 | 63349704 |
Blood cholesterol increased | 36.27 | 10.08 | 78 | 120806 | 93954 | 63274184 |
Hereditary angioedema | 35.84 | 10.08 | 57 | 120827 | 7505 | 63360633 |
Hostility | 35.36 | 10.08 | 29 | 120855 | 1843 | 63366295 |
Headache | 35.01 | 10.08 | 1506 | 119378 | 631735 | 62736403 |
Vertigo | 34.79 | 10.08 | 214 | 120670 | 59673 | 63308465 |
Treatment failure | 34.71 | 10.08 | 229 | 120655 | 198814 | 63169324 |
Pleurothotonus | 34.46 | 10.08 | 25 | 120859 | 1324 | 63366814 |
Cardiac failure | 34.34 | 10.08 | 74 | 120810 | 89068 | 63279070 |
Akathisia | 34.15 | 10.08 | 62 | 120822 | 9084 | 63359054 |
Rheumatoid arthritis | 34.00 | 10.08 | 314 | 120570 | 253505 | 63114633 |
Alcoholism | 34.00 | 10.08 | 28 | 120856 | 1790 | 63366348 |
Listless | 33.72 | 10.08 | 34 | 120850 | 2826 | 63365312 |
Hip arthroplasty | 33.51 | 10.08 | 25 | 120859 | 47621 | 63320517 |
Osteopenia | 33.38 | 10.08 | 98 | 120786 | 19687 | 63348451 |
Cardiac arrest | 33.28 | 10.08 | 295 | 120589 | 92250 | 63275888 |
Muscle rigidity | 33.26 | 10.08 | 70 | 120814 | 11430 | 63356708 |
Osteosclerosis | 33.21 | 10.08 | 39 | 120845 | 3849 | 63364289 |
Breath sounds abnormal | 33.15 | 10.08 | 68 | 120816 | 10905 | 63357233 |
Dissociation | 33.14 | 10.08 | 34 | 120850 | 2885 | 63365253 |
Blood potassium increased | 33.13 | 10.08 | 93 | 120791 | 18216 | 63349922 |
Hospitalisation | 33.11 | 10.08 | 276 | 120608 | 84805 | 63283333 |
Encephalopathy | 32.66 | 10.08 | 153 | 120731 | 38467 | 63329671 |
Cardiac murmur | 32.55 | 10.08 | 80 | 120804 | 14472 | 63353666 |
Cholestasis | 32.48 | 10.08 | 8 | 120876 | 29426 | 63338712 |
Bronchiectasis | 32.21 | 10.08 | 85 | 120799 | 16057 | 63352081 |
Tardive dyskinesia | 32.21 | 10.08 | 58 | 120826 | 8444 | 63359694 |
Multiple sclerosis relapse | 31.89 | 10.08 | 179 | 120705 | 48299 | 63319839 |
Dry eye | 31.25 | 10.08 | 157 | 120727 | 40604 | 63327534 |
Disease progression | 31.18 | 10.08 | 124 | 120760 | 122634 | 63245504 |
Psoriasis | 31.17 | 10.08 | 277 | 120607 | 86680 | 63281458 |
Lung opacity | 30.83 | 10.08 | 34 | 120850 | 3134 | 63365004 |
Mental disorder | 30.82 | 10.08 | 114 | 120770 | 25805 | 63342333 |
Bronchopulmonary aspergillosis allergic | 30.66 | 10.08 | 29 | 120855 | 2229 | 63365909 |
Renal disorder | 30.40 | 10.08 | 134 | 120750 | 32840 | 63335298 |
Macular degeneration | 30.28 | 10.08 | 5 | 120879 | 24371 | 63343767 |
Inhibitory drug interaction | 30.22 | 10.08 | 32 | 120852 | 2817 | 63365321 |
Libido increased | 30.05 | 10.08 | 23 | 120861 | 1322 | 63366816 |
Acute kidney injury | 29.87 | 10.08 | 339 | 120545 | 263076 | 63105062 |
Fibromyalgia | 29.77 | 10.08 | 258 | 120626 | 80162 | 63287976 |
Platelet count decreased | 29.68 | 10.08 | 117 | 120767 | 116005 | 63252133 |
Infection susceptibility increased | 29.55 | 10.08 | 35 | 120849 | 3486 | 63364652 |
Live birth | 28.21 | 10.08 | 7 | 120877 | 25623 | 63342515 |
Cardiac failure congestive | 27.73 | 10.08 | 87 | 120797 | 92346 | 63275792 |
Toxic epidermal necrolysis | 27.73 | 10.08 | 7 | 120877 | 25327 | 63342811 |
Hallucination, auditory | 27.10 | 10.08 | 69 | 120815 | 12755 | 63355383 |
Sternal fracture | 26.95 | 10.08 | 27 | 120857 | 2227 | 63365911 |
Premature delivery | 26.83 | 10.08 | 12 | 120872 | 30269 | 63337869 |
Aspiration | 26.80 | 10.08 | 62 | 120822 | 10789 | 63357349 |
Cognitive disorder | 26.70 | 10.08 | 190 | 120694 | 55625 | 63312513 |
Muscle twitching | 26.38 | 10.08 | 90 | 120794 | 19578 | 63348560 |
Coma | 26.23 | 10.08 | 211 | 120673 | 64153 | 63303985 |
Infection | 25.95 | 10.08 | 295 | 120589 | 228878 | 63139260 |
Soft tissue injury | 25.91 | 10.08 | 23 | 120861 | 1629 | 63366509 |
Major depression | 25.79 | 10.08 | 51 | 120833 | 7967 | 63360171 |
Dyskinesia | 25.77 | 10.08 | 125 | 120759 | 31877 | 63336261 |
Peripheral swelling | 25.74 | 10.08 | 354 | 120530 | 265588 | 63102550 |
Prescription drug used without a prescription | 25.67 | 10.08 | 27 | 120857 | 2359 | 63365779 |
Dermatitis atopic | 25.62 | 10.08 | 57 | 120827 | 9667 | 63358471 |
Sedation | 25.33 | 10.08 | 143 | 120741 | 38666 | 63329472 |
Knee arthroplasty | 25.31 | 10.08 | 40 | 120844 | 54166 | 63313972 |
Blood bilirubin increased | 25 | 10.08 | 138 | 120746 | 37002 | 63331136 |
Sarcoidosis | 24.99 | 10.08 | 47 | 120837 | 7075 | 63361063 |
Impaired quality of life | 24.93 | 10.08 | 70 | 120814 | 13713 | 63354425 |
Hypertonia | 24.85 | 10.08 | 37 | 120847 | 4600 | 63363538 |
Sleep disorder | 24.84 | 10.08 | 251 | 120633 | 81315 | 63286823 |
Depressed level of consciousness | 24.48 | 10.08 | 202 | 120682 | 61876 | 63306262 |
Sinus bradycardia | 24.48 | 10.08 | 72 | 120812 | 14479 | 63353659 |
Intentional product misuse | 24.44 | 10.08 | 199 | 120685 | 60718 | 63307420 |
Psychomotor hyperactivity | 24.25 | 10.08 | 59 | 120825 | 10604 | 63357534 |
Sensation of foreign body | 24.20 | 10.08 | 37 | 120847 | 4708 | 63363430 |
Post-traumatic stress disorder | 24.09 | 10.08 | 39 | 120845 | 5212 | 63362926 |
Drug screen positive | 23.96 | 10.08 | 32 | 120852 | 3597 | 63364541 |
Mood altered | 23.90 | 10.08 | 72 | 120812 | 14671 | 63353467 |
Autonomic nervous system imbalance | 23.63 | 10.08 | 28 | 120856 | 2790 | 63365348 |
Bone erosion | 23.48 | 10.08 | 3 | 120881 | 17714 | 63350424 |
Post-traumatic neck syndrome | 23.26 | 10.08 | 24 | 120860 | 2050 | 63366088 |
Hepatotoxicity | 23.20 | 10.08 | 135 | 120749 | 36906 | 63331232 |
Perseveration | 23.02 | 10.08 | 11 | 120873 | 264 | 63367874 |
Liver disorder | 22.88 | 10.08 | 42 | 120842 | 53645 | 63314493 |
Sense of a foreshortened future | 22.87 | 10.08 | 5 | 120879 | 5 | 63368133 |
Product physical issue | 22.86 | 10.08 | 37 | 120847 | 4943 | 63363195 |
Gambling disorder | 22.82 | 10.08 | 19 | 120865 | 1233 | 63366905 |
Full blood count abnormal | 22.81 | 10.08 | 120 | 120764 | 31597 | 63336541 |
Epilepsy | 22.72 | 10.08 | 107 | 120777 | 26958 | 63341180 |
Abnormal dreams | 22.66 | 10.08 | 57 | 120827 | 10459 | 63357679 |
Glucose tolerance impaired | 22.57 | 10.08 | 43 | 120841 | 6534 | 63361604 |
Tonic clonic movements | 22.55 | 10.08 | 20 | 120864 | 1415 | 63366723 |
Cytomegalovirus infection | 22.53 | 10.08 | 6 | 120878 | 20946 | 63347192 |
Unresponsive to stimuli | 22.33 | 10.08 | 125 | 120759 | 33691 | 63334447 |
Apallic syndrome | 22.24 | 10.08 | 15 | 120869 | 706 | 63367432 |
Mental status changes | 22.06 | 10.08 | 140 | 120744 | 39459 | 63328679 |
Clonus | 22.04 | 10.08 | 35 | 120849 | 4601 | 63363537 |
Productive cough | 21.96 | 10.08 | 200 | 120684 | 63008 | 63305130 |
Meningitis streptococcal | 21.94 | 10.08 | 9 | 120875 | 148 | 63367990 |
Concussion | 21.94 | 10.08 | 52 | 120832 | 9192 | 63358946 |
Abortion spontaneous | 21.87 | 10.08 | 35 | 120849 | 47160 | 63320978 |
Middle insomnia | 21.69 | 10.08 | 63 | 120821 | 12580 | 63355558 |
Therapy non-responder | 21.68 | 10.08 | 73 | 120811 | 75828 | 63292310 |
Neuroleptic malignant syndrome | 21.58 | 10.08 | 61 | 120823 | 11995 | 63356143 |
Nasal polyps | 21.37 | 10.08 | 40 | 120844 | 5999 | 63362139 |
Urinary retention | 21.35 | 10.08 | 114 | 120770 | 30187 | 63337951 |
Compartment syndrome | 21.35 | 10.08 | 24 | 120860 | 2260 | 63365878 |
Affective disorder | 20.87 | 10.08 | 40 | 120844 | 6106 | 63362032 |
Reduced facial expression | 20.71 | 10.08 | 22 | 120862 | 1944 | 63366194 |
Psychomotor skills impaired | 20.64 | 10.08 | 24 | 120860 | 2344 | 63365794 |
Torsade de pointes | 20.52 | 10.08 | 64 | 120820 | 13287 | 63354851 |
Depressed mood | 20.51 | 10.08 | 139 | 120745 | 40052 | 63328086 |
Haemangioma congenital | 20.48 | 10.08 | 12 | 120872 | 440 | 63367698 |
Pregnancy | 20.41 | 10.08 | 24 | 120860 | 36812 | 63331326 |
Head discomfort | 20.34 | 10.08 | 64 | 120820 | 13351 | 63354787 |
Multiple organ dysfunction syndrome | 20.32 | 10.08 | 49 | 120835 | 56703 | 63311435 |
Restlessness | 20.20 | 10.08 | 110 | 120774 | 29343 | 63338795 |
Cholelithiasis | 20.12 | 10.08 | 148 | 120736 | 43777 | 63324361 |
Infantile vomiting | 20.11 | 10.08 | 8 | 120876 | 121 | 63368017 |
Solar urticaria | 20.03 | 10.08 | 7 | 120877 | 72 | 63368066 |
Inappropriate schedule of product administration | 19.89 | 10.08 | 293 | 120591 | 103672 | 63264466 |
Blood calcium decreased | 19.76 | 10.08 | 13 | 120871 | 26438 | 63341700 |
Accommodation disorder | 19.63 | 10.08 | 11 | 120873 | 370 | 63367768 |
Chronic obstructive pulmonary disease | 19.62 | 10.08 | 194 | 120690 | 62492 | 63305646 |
Skin texture abnormal | 19.61 | 10.08 | 12 | 120872 | 477 | 63367661 |
Bursitis | 19.61 | 10.08 | 25 | 120859 | 37016 | 63331122 |
Initial insomnia | 19.60 | 10.08 | 39 | 120845 | 6118 | 63362020 |
Oppositional defiant disorder | 19.45 | 10.08 | 6 | 120878 | 40 | 63368098 |
Mobility decreased | 19.33 | 10.08 | 143 | 120741 | 121016 | 63247122 |
Tachyphrenia | 19.33 | 10.08 | 18 | 120866 | 1356 | 63366782 |
Purple glove syndrome | 19.30 | 10.08 | 9 | 120875 | 204 | 63367934 |
Burning mouth syndrome | 19.12 | 10.08 | 12 | 120872 | 499 | 63367639 |
Hyperhidrosis | 19.12 | 10.08 | 300 | 120584 | 107536 | 63260602 |
Lung disorder | 19.10 | 10.08 | 58 | 120826 | 62203 | 63305935 |
Septic shock | 19.09 | 10.08 | 64 | 120820 | 66565 | 63301573 |
Dysphoria | 18.97 | 10.08 | 34 | 120850 | 4932 | 63363206 |
Urticaria | 18.93 | 10.08 | 213 | 120671 | 165589 | 63202549 |
Premature baby | 18.71 | 10.08 | 8 | 120876 | 20727 | 63347411 |
Anger | 18.49 | 10.08 | 59 | 120825 | 12397 | 63355741 |
Nasopharyngitis | 18.44 | 10.08 | 357 | 120527 | 253900 | 63114238 |
Haematocrit decreased | 18.39 | 10.08 | 29 | 120855 | 39311 | 63328827 |
Joint range of motion decreased | 18.10 | 10.08 | 21 | 120863 | 32407 | 63335731 |
Ejection fraction decreased | 18.05 | 10.08 | 10 | 120874 | 22322 | 63345816 |
Drug withdrawal syndrome neonatal | 17.99 | 10.08 | 21 | 120863 | 2060 | 63366078 |
Hepatic failure | 17.92 | 10.08 | 25 | 120859 | 35631 | 63332507 |
Heart rate abnormal | 17.80 | 10.08 | 33 | 120851 | 4914 | 63363224 |
Hepatic function abnormal | 17.73 | 10.08 | 27 | 120857 | 37115 | 63331023 |
Delirium | 17.60 | 10.08 | 160 | 120724 | 50381 | 63317757 |
Maximal voluntary ventilation abnormal | 17.42 | 10.08 | 5 | 120879 | 25 | 63368113 |
Apathy | 17.24 | 10.08 | 46 | 120838 | 8748 | 63359390 |
Substance abuse | 17.21 | 10.08 | 32 | 120852 | 4775 | 63363363 |
Accidental death | 17.18 | 10.08 | 20 | 120864 | 1956 | 63366182 |
Nystagmus | 17.00 | 10.08 | 37 | 120847 | 6183 | 63361955 |
Hyperkalaemia | 16.98 | 10.08 | 50 | 120834 | 54153 | 63313985 |
Liver function test abnormal | 16.94 | 10.08 | 42 | 120842 | 48139 | 63319999 |
Nervousness | 16.93 | 10.08 | 109 | 120775 | 30870 | 63337268 |
Affect lability | 16.72 | 10.08 | 53 | 120831 | 11098 | 63357040 |
Bradycardia | 16.71 | 10.08 | 213 | 120671 | 73014 | 63295124 |
Musculoskeletal pain | 16.66 | 10.08 | 105 | 120779 | 92172 | 63275966 |
Myoclonus | 16.58 | 10.08 | 67 | 120817 | 15801 | 63352337 |
Deep vein thrombosis | 16.37 | 10.08 | 93 | 120791 | 83707 | 63284431 |
Mydriasis | 16.29 | 10.08 | 55 | 120829 | 11901 | 63356237 |
Priapism | 16.14 | 10.08 | 7 | 120877 | 133 | 63368005 |
Body height decreased | 16.13 | 10.08 | 49 | 120835 | 10029 | 63358109 |
Vasoplegia syndrome | 16.13 | 10.08 | 18 | 120866 | 1681 | 63366457 |
Hepatocellular injury | 16.09 | 10.08 | 17 | 120867 | 27364 | 63340774 |
Small for dates baby | 16.05 | 10.08 | 27 | 120857 | 3724 | 63364414 |
Renal failure | 15.97 | 10.08 | 145 | 120739 | 117507 | 63250631 |
Slow speech | 15.91 | 10.08 | 17 | 120867 | 1512 | 63366626 |
Anaphylactic shock | 15.86 | 10.08 | 13 | 120871 | 23620 | 63344518 |
Sedative therapy | 15.80 | 10.08 | 3 | 120881 | 0 | 63368138 |
Wound infection fungal | 15.72 | 10.08 | 7 | 120877 | 142 | 63367996 |
Plasma cell mastitis | 15.53 | 10.08 | 5 | 120879 | 39 | 63368099 |
Coagulopathy | 15.48 | 10.08 | 10 | 120874 | 20534 | 63347604 |
Rash maculo-papular | 15.40 | 10.08 | 23 | 120861 | 31873 | 63336265 |
Hepatitis | 15.34 | 10.08 | 33 | 120851 | 39755 | 63328383 |
Tongue discolouration | 15.32 | 10.08 | 24 | 120860 | 3119 | 63365019 |
Hypercholesterolaemia | 15.25 | 10.08 | 11 | 120873 | 21323 | 63346815 |
Eczema eyelids | 15.25 | 10.08 | 7 | 120877 | 153 | 63367985 |
Angioedema | 15.20 | 10.08 | 44 | 120840 | 47921 | 63320217 |
Creatinine renal clearance decreased | 15.19 | 10.08 | 6 | 120878 | 16302 | 63351836 |
International normalised ratio increased | 15.15 | 10.08 | 42 | 120842 | 46383 | 63321755 |
Sepsis | 15.10 | 10.08 | 203 | 120681 | 152920 | 63215218 |
Drug resistance | 14.92 | 10.08 | 13 | 120871 | 22920 | 63345218 |
Polyglandular autoimmune syndrome type II | 14.80 | 10.08 | 5 | 120879 | 46 | 63368092 |
Large for dates baby | 14.78 | 10.08 | 10 | 120874 | 473 | 63367665 |
Oedema | 14.74 | 10.08 | 117 | 120767 | 97505 | 63270633 |
Disseminated intravascular coagulation | 14.73 | 10.08 | 9 | 120875 | 19042 | 63349096 |
Blood prolactin increased | 14.70 | 10.08 | 25 | 120859 | 3478 | 63364660 |
Screaming | 14.65 | 10.08 | 24 | 120860 | 3238 | 63364900 |
Balance disorder | 14.64 | 10.08 | 234 | 120650 | 84188 | 63283950 |
Thyroglobulin increased | 14.62 | 10.08 | 5 | 120879 | 48 | 63368090 |
Feeling abnormal | 14.60 | 10.08 | 378 | 120506 | 148014 | 63220124 |
Acute respiratory distress syndrome | 14.53 | 10.08 | 14 | 120870 | 23520 | 63344618 |
Hyponatriuria | 14.28 | 10.08 | 4 | 120880 | 18 | 63368120 |
Tracheitis | 14.20 | 10.08 | 12 | 120872 | 795 | 63367343 |
Arthralgia | 14.15 | 10.08 | 915 | 119969 | 568795 | 62799343 |
Personality disorder | 14.13 | 10.08 | 33 | 120851 | 5778 | 63362360 |
Drug ineffective for unapproved indication | 14.05 | 10.08 | 112 | 120772 | 33951 | 63334187 |
Lip dry | 13.91 | 10.08 | 6 | 120878 | 15464 | 63352674 |
Drug dependence | 13.91 | 10.08 | 87 | 120797 | 24396 | 63343742 |
Economic problem | 13.87 | 10.08 | 18 | 120866 | 1968 | 63366170 |
Periorbital swelling | 13.83 | 10.08 | 22 | 120862 | 2896 | 63365242 |
Mitral valve thickening | 13.77 | 10.08 | 4 | 120880 | 21 | 63368117 |
Patient restraint | 13.72 | 10.08 | 3 | 120881 | 3 | 63368135 |
Serum serotonin increased | 13.60 | 10.08 | 7 | 120877 | 198 | 63367940 |
Pain | 13.59 | 10.08 | 1220 | 119664 | 739408 | 62628730 |
Peritoneal perforation | 13.56 | 10.08 | 6 | 120878 | 120 | 63368018 |
Therapy interrupted | 13.55 | 10.08 | 107 | 120777 | 32348 | 63335790 |
Myoglobin blood increased | 13.54 | 10.08 | 15 | 120869 | 1390 | 63366748 |
Therapeutic response shortened | 13.07 | 10.08 | 51 | 120833 | 11837 | 63356301 |
Pneumocystis jirovecii pneumonia | 13.07 | 10.08 | 8 | 120876 | 16906 | 63351232 |
Interstitial lung disease | 13.04 | 10.08 | 67 | 120817 | 61841 | 63306297 |
Respiratory acidosis | 13.03 | 10.08 | 35 | 120849 | 6680 | 63361458 |
Personal relationship issue | 12.73 | 10.08 | 5 | 120879 | 73 | 63368065 |
C-reactive protein increased | 12.73 | 10.08 | 117 | 120767 | 94590 | 63273548 |
Gait apraxia | 12.68 | 10.08 | 4 | 120880 | 29 | 63368109 |
Gastroenteritis radiation | 12.64 | 10.08 | 9 | 120875 | 463 | 63367675 |
Immobile | 12.58 | 10.08 | 32 | 120852 | 5911 | 63362227 |
Myelosuppression | 12.54 | 10.08 | 16 | 120868 | 23687 | 63344451 |
Holmes-Adie pupil | 12.45 | 10.08 | 4 | 120880 | 31 | 63368107 |
Heterophoria | 12.45 | 10.08 | 4 | 120880 | 31 | 63368107 |
Mood swings | 12.41 | 10.08 | 68 | 120816 | 18180 | 63349958 |
Gastrointestinal haemorrhage | 12.38 | 10.08 | 97 | 120787 | 81079 | 63287059 |
Nausea | 12.35 | 10.08 | 1830 | 119054 | 852641 | 62515497 |
Product size issue | 12.34 | 10.08 | 8 | 120876 | 352 | 63367786 |
Anuria | 12.33 | 10.08 | 52 | 120832 | 12499 | 63355639 |
Infusion site pruritus | 12.27 | 10.08 | 32 | 120852 | 6003 | 63362135 |
Extra dose administered | 12.23 | 10.08 | 33 | 120851 | 6317 | 63361821 |
Accidental overdose | 12.12 | 10.08 | 81 | 120803 | 23228 | 63344910 |
Facet joint syndrome | 12.10 | 10.08 | 4 | 120880 | 12134 | 63356004 |
Foetal death | 12.08 | 10.08 | 3 | 120881 | 10977 | 63357161 |
Decreased interest | 12.08 | 10.08 | 22 | 120862 | 3232 | 63364906 |
Obsessive-compulsive disorder | 12.08 | 10.08 | 25 | 120859 | 4035 | 63364103 |
Human herpesvirus 6 infection reactivation | 12.06 | 10.08 | 8 | 120876 | 366 | 63367772 |
Weight decreased | 11.97 | 10.08 | 643 | 120241 | 276155 | 63091983 |
Alcohol withdrawal syndrome | 11.96 | 10.08 | 11 | 120873 | 816 | 63367322 |
Wandering pacemaker | 11.92 | 10.08 | 3 | 120881 | 8 | 63368130 |
Psoriatic arthropathy | 11.90 | 10.08 | 114 | 120770 | 91406 | 63276732 |
Grip strength decreased | 11.84 | 10.08 | 15 | 120869 | 22272 | 63345866 |
Neonatal seizure | 11.82 | 10.08 | 9 | 120875 | 513 | 63367625 |
Disorientation | 11.81 | 10.08 | 121 | 120763 | 39331 | 63328807 |
Sinusitis | 11.75 | 10.08 | 335 | 120549 | 226318 | 63141820 |
Sympathomimetic effect | 11.73 | 10.08 | 5 | 120879 | 91 | 63368047 |
Foreign body | 11.60 | 10.08 | 18 | 120866 | 2320 | 63365818 |
Hyperbilirubinaemia neonatal | 11.59 | 10.08 | 8 | 120876 | 391 | 63367747 |
Toxic skin eruption | 11.58 | 10.08 | 5 | 120879 | 12880 | 63355258 |
Pericardial effusion | 11.53 | 10.08 | 25 | 120859 | 30033 | 63338105 |
Haemophagocytic lymphohistiocytosis | 11.51 | 10.08 | 3 | 120881 | 10624 | 63357514 |
Jaundice | 11.50 | 10.08 | 24 | 120860 | 29227 | 63338911 |
Product complaint | 11.47 | 10.08 | 5 | 120879 | 12804 | 63355334 |
Product shape issue | 11.44 | 10.08 | 5 | 120879 | 97 | 63368041 |
Hyperlipidaemia | 11.40 | 10.08 | 70 | 120814 | 19501 | 63348637 |
Genital infection female | 11.34 | 10.08 | 5 | 120879 | 99 | 63368039 |
Injection site induration | 11.32 | 10.08 | 41 | 120843 | 9185 | 63358953 |
Suicidal behaviour | 11.30 | 10.08 | 19 | 120865 | 2620 | 63365518 |
Skin sensitisation | 11.28 | 10.08 | 11 | 120873 | 878 | 63367260 |
Presyncope | 11.27 | 10.08 | 91 | 120793 | 27694 | 63340444 |
Tension | 11.20 | 10.08 | 21 | 120863 | 3154 | 63364984 |
Product substitution issue | 11.14 | 10.08 | 60 | 120824 | 15936 | 63352202 |
Malignant melanoma | 11.12 | 10.08 | 47 | 120837 | 11309 | 63356829 |
Exostosis | 11.12 | 10.08 | 65 | 120819 | 17797 | 63350341 |
Device expulsion | 11.09 | 10.08 | 32 | 120852 | 34890 | 63333248 |
Dyslipidaemia | 10.96 | 10.08 | 35 | 120849 | 7358 | 63360780 |
Intervertebral disc degeneration | 10.95 | 10.08 | 59 | 120825 | 15673 | 63352465 |
Speech disorder | 10.95 | 10.08 | 122 | 120762 | 40507 | 63327631 |
Illness | 10.89 | 10.08 | 142 | 120742 | 48917 | 63319221 |
Acute myeloid leukaemia | 10.82 | 10.08 | 10 | 120874 | 17137 | 63351001 |
Compulsive shopping | 10.79 | 10.08 | 10 | 120874 | 749 | 63367389 |
Lupus-like syndrome | 10.79 | 10.08 | 8 | 120876 | 15287 | 63352851 |
Hypoaesthesia | 10.74 | 10.08 | 407 | 120477 | 167986 | 63200152 |
Long QT syndrome | 10.72 | 10.08 | 21 | 120863 | 3258 | 63364880 |
Joint effusion | 10.70 | 10.08 | 10 | 120874 | 17050 | 63351088 |
Injection site necrosis | 10.69 | 10.08 | 13 | 120871 | 1331 | 63366807 |
Knee deformity | 10.68 | 10.08 | 13 | 120871 | 1332 | 63366806 |
Hyperthermia | 10.66 | 10.08 | 40 | 120844 | 9116 | 63359022 |
Rapid eye movement sleep behaviour disorder | 10.58 | 10.08 | 7 | 120877 | 319 | 63367819 |
Osteonecrosis of jaw | 10.57 | 10.08 | 33 | 120851 | 35090 | 63333048 |
Galactorrhoea | 10.55 | 10.08 | 24 | 120860 | 4131 | 63364007 |
Multiple sclerosis | 10.53 | 10.08 | 81 | 120803 | 24291 | 63343847 |
Metastases to liver | 10.52 | 10.08 | 18 | 120866 | 23621 | 63344517 |
Drug detoxification | 10.46 | 10.08 | 7 | 120877 | 325 | 63367813 |
Juvenile melanoma benign | 10.45 | 10.08 | 3 | 120881 | 15 | 63368123 |
Apraxia | 10.44 | 10.08 | 15 | 120869 | 1806 | 63366332 |
Neoplasm progression | 10.43 | 10.08 | 35 | 120849 | 36393 | 63331745 |
Morbid thoughts | 10.43 | 10.08 | 9 | 120875 | 614 | 63367524 |
Thinking abnormal | 10.38 | 10.08 | 44 | 120840 | 10599 | 63357539 |
Hypotension | 10.38 | 10.08 | 626 | 120258 | 271978 | 63096160 |
Electrocardiogram T wave peaked | 10.32 | 10.08 | 6 | 120878 | 217 | 63367921 |
Impaired gastric emptying | 10.30 | 10.08 | 43 | 120841 | 10289 | 63357849 |
Kluver-Bucy syndrome | 10.29 | 10.08 | 3 | 120881 | 16 | 63368122 |
Generalised oedema | 10.25 | 10.08 | 9 | 120875 | 15809 | 63352329 |
Cardiomyopathy | 10.24 | 10.08 | 11 | 120873 | 17573 | 63350565 |
Borderline personality disorder | 10.23 | 10.08 | 10 | 120874 | 801 | 63367337 |
Hypokinesia | 10.21 | 10.08 | 53 | 120831 | 13883 | 63354255 |
Urine odour abnormal | 10.17 | 10.08 | 31 | 120853 | 6358 | 63361780 |
Immune-mediated lung disease | 10.14 | 10.08 | 9 | 120875 | 637 | 63367501 |
Postural tremor | 10.11 | 10.08 | 7 | 120877 | 344 | 63367794 |
Inappropriate antidiuretic hormone secretion | 10.10 | 10.08 | 57 | 120827 | 15405 | 63352733 |
Compulsive sexual behaviour | 10.09 | 10.08 | 4 | 120880 | 60 | 63368078 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 580.72 | 11.26 | 708 | 49325 | 97460 | 34809438 |
Serotonin syndrome | 470.87 | 11.26 | 315 | 49718 | 19618 | 34887280 |
Priapism | 401.71 | 11.26 | 178 | 49855 | 4816 | 34902082 |
Toxicity to various agents | 389.10 | 11.26 | 873 | 49160 | 199489 | 34707409 |
Drug abuse | 306.72 | 11.26 | 526 | 49507 | 98570 | 34808328 |
Sopor | 277.42 | 11.26 | 188 | 49845 | 11948 | 34894950 |
Intentional overdose | 147.05 | 11.26 | 241 | 49792 | 43433 | 34863465 |
Suicidal ideation | 137.50 | 11.26 | 224 | 49809 | 40164 | 34866734 |
Suicide attempt | 117.28 | 11.26 | 205 | 49828 | 38911 | 34867987 |
Overdose | 114.87 | 11.26 | 338 | 49695 | 90721 | 34816177 |
Drug interaction | 105.20 | 11.26 | 616 | 49417 | 225330 | 34681568 |
Agitation | 89.16 | 11.26 | 230 | 49803 | 57169 | 34849729 |
Intrusive thoughts | 88.07 | 11.26 | 28 | 50005 | 287 | 34906611 |
Cardio-respiratory arrest | 80.26 | 11.26 | 216 | 49817 | 55057 | 34851841 |
Electrocardiogram QT prolonged | 79.60 | 11.26 | 179 | 49854 | 40773 | 34866125 |
Insomnia | 78.89 | 11.26 | 326 | 49707 | 103581 | 34803317 |
Head discomfort | 76.02 | 11.26 | 56 | 49977 | 4060 | 34902838 |
Somnolence | 72.43 | 11.26 | 333 | 49700 | 110783 | 34796115 |
Anxiety | 70.08 | 11.26 | 305 | 49728 | 99123 | 34807775 |
Depression | 68.54 | 11.26 | 298 | 49735 | 96800 | 34810098 |
Febrile neutropenia | 65.07 | 11.26 | 60 | 49973 | 136789 | 34770109 |
Aggression | 64.51 | 11.26 | 160 | 49873 | 38804 | 34868094 |
Homicidal ideation | 62.34 | 11.26 | 42 | 49991 | 2640 | 34904258 |
Antidepressant drug level above therapeutic | 61.15 | 11.26 | 20 | 50013 | 226 | 34906672 |
Tachyphrenia | 58.78 | 11.26 | 31 | 50002 | 1238 | 34905660 |
Mental status changes | 57.46 | 11.26 | 151 | 49882 | 37932 | 34868966 |
Anaemia | 56.53 | 11.26 | 160 | 49873 | 233175 | 34673723 |
Analgesic drug level above therapeutic | 56.43 | 11.26 | 20 | 50013 | 293 | 34906605 |
Pancytopenia | 51.08 | 11.26 | 37 | 49996 | 95120 | 34811778 |
Environmental exposure | 50.15 | 11.26 | 18 | 50015 | 274 | 34906624 |
Sedation | 47.91 | 11.26 | 98 | 49935 | 20908 | 34885990 |
Confusional state | 47.51 | 11.26 | 361 | 49672 | 143799 | 34763099 |
Renal failure | 46.33 | 11.26 | 72 | 49961 | 130485 | 34776413 |
Ventricular tachyarrhythmia | 45.81 | 11.26 | 18 | 50015 | 356 | 34906542 |
Paranoia | 45.26 | 11.26 | 70 | 49963 | 11998 | 34894900 |
Device dislocation | 45.01 | 11.26 | 50 | 49983 | 6199 | 34900699 |
Withdrawal syndrome | 44.98 | 11.26 | 71 | 49962 | 12384 | 34894514 |
Disease progression | 42.91 | 11.26 | 55 | 49978 | 108022 | 34798876 |
Irritability | 42.57 | 11.26 | 103 | 49930 | 24587 | 34882311 |
Anger | 41.89 | 11.26 | 67 | 49966 | 11817 | 34895081 |
Pyrexia | 41.41 | 11.26 | 293 | 49740 | 332720 | 34574178 |
Drug withdrawal syndrome neonatal | 40.94 | 11.26 | 37 | 49996 | 3582 | 34903316 |
Neck pain | 40.80 | 11.26 | 103 | 49930 | 25246 | 34881652 |
Thrombocytopenia | 39.39 | 11.26 | 105 | 49928 | 156142 | 34750756 |
Parkinsonism | 37.46 | 11.26 | 52 | 49981 | 8086 | 34898812 |
Bradyphrenia | 37.36 | 11.26 | 40 | 49993 | 4758 | 34902140 |
Alcoholism | 36.90 | 11.26 | 32 | 50001 | 2933 | 34903965 |
Interstitial lung disease | 36.86 | 11.26 | 24 | 50009 | 65258 | 34841640 |
Intentional product misuse | 36.86 | 11.26 | 146 | 49887 | 45465 | 34861433 |
Penis injury | 36.70 | 11.26 | 14 | 50019 | 255 | 34906643 |
Symptom masked | 36.61 | 11.26 | 18 | 50015 | 619 | 34906279 |
Migraine | 35.75 | 11.26 | 78 | 49955 | 17400 | 34889498 |
Loss of libido | 34.74 | 11.26 | 29 | 50004 | 2523 | 34904375 |
Tremor | 33.13 | 11.26 | 217 | 49816 | 82370 | 34824528 |
Product dose omission issue | 33.04 | 11.26 | 288 | 49745 | 119423 | 34787475 |
Sleep disorder | 32.85 | 11.26 | 110 | 49923 | 31578 | 34875320 |
Hallucination, auditory | 32.54 | 11.26 | 60 | 49973 | 11857 | 34895041 |
Injection site reaction | 32.35 | 11.26 | 63 | 49970 | 12970 | 34893928 |
Intentional self-injury | 32.29 | 11.26 | 65 | 49968 | 13706 | 34893192 |
Respiratory arrest | 31.46 | 11.26 | 100 | 49933 | 27943 | 34878955 |
Dysphoria | 31.01 | 11.26 | 26 | 50007 | 2276 | 34904622 |
Restless legs syndrome | 30.69 | 11.26 | 48 | 49985 | 8306 | 34898592 |
Fall | 30.59 | 11.26 | 433 | 49600 | 202452 | 34704446 |
Poor feeding infant | 30.34 | 11.26 | 15 | 50018 | 522 | 34906376 |
Renal impairment | 29.95 | 11.26 | 56 | 49977 | 94457 | 34812441 |
Mood swings | 29.86 | 11.26 | 46 | 49987 | 7855 | 34899043 |
General physical health deterioration | 29.52 | 11.26 | 90 | 49943 | 128179 | 34778719 |
Delusion of replacement | 29.23 | 11.26 | 10 | 50023 | 131 | 34906767 |
Septic shock | 29.08 | 11.26 | 36 | 49997 | 71798 | 34835100 |
Hyperreflexia | 29.06 | 11.26 | 29 | 50004 | 3177 | 34903721 |
Clonus | 28.93 | 11.26 | 27 | 50006 | 2723 | 34904175 |
Shock | 28.77 | 11.26 | 88 | 49945 | 24091 | 34882807 |
Psychotic disorder | 28.17 | 11.26 | 88 | 49945 | 24364 | 34882534 |
Device malfunction | 27.87 | 11.26 | 52 | 49981 | 10369 | 34896529 |
Penile haemorrhage | 27.70 | 11.26 | 15 | 50018 | 632 | 34906266 |
Delusion | 27.69 | 11.26 | 58 | 49975 | 12577 | 34894321 |
Homicide | 27.32 | 11.26 | 17 | 50016 | 932 | 34905966 |
Neutropenia | 26.95 | 11.26 | 124 | 49909 | 156654 | 34750244 |
Persistent depressive disorder | 26.92 | 11.26 | 12 | 50021 | 329 | 34906569 |
Pre-existing condition improved | 26.41 | 11.26 | 25 | 50008 | 2567 | 34904331 |
Hepatic function abnormal | 25.46 | 11.26 | 16 | 50017 | 44347 | 34862551 |
Hallucination, visual | 25.27 | 11.26 | 69 | 49964 | 17722 | 34889176 |
Akathisia | 24.93 | 11.26 | 43 | 49990 | 8066 | 34898832 |
Depressed mood | 24.58 | 11.26 | 72 | 49961 | 19245 | 34887653 |
Sepsis | 24.51 | 11.26 | 139 | 49894 | 166422 | 34740476 |
Cytomegalovirus infection | 24.48 | 11.26 | 4 | 50029 | 26131 | 34880767 |
Suspected suicide | 24.38 | 11.26 | 32 | 50001 | 4716 | 34902182 |
Foaming at mouth | 24.33 | 11.26 | 15 | 50018 | 809 | 34906089 |
Initial insomnia | 24.25 | 11.26 | 26 | 50007 | 3098 | 34903800 |
Polymerase chain reaction | 24.10 | 11.26 | 8 | 50025 | 95 | 34906803 |
Ascites | 23.83 | 11.26 | 19 | 50014 | 46552 | 34860346 |
Mucosal inflammation | 23.48 | 11.26 | 13 | 50020 | 38609 | 34868289 |
Psychomotor hyperactivity | 23.26 | 11.26 | 46 | 49987 | 9576 | 34897322 |
Delirium | 23.04 | 11.26 | 124 | 49909 | 43867 | 34863031 |
Neuroleptic malignant syndrome | 22.97 | 11.26 | 67 | 49966 | 17867 | 34889031 |
Feeling abnormal | 22.87 | 11.26 | 162 | 49871 | 63073 | 34843825 |
Eye haematoma | 22.73 | 11.26 | 7 | 50026 | 64 | 34906834 |
Accidental poisoning | 22.36 | 11.26 | 14 | 50019 | 776 | 34906122 |
Hallucination | 22.30 | 11.26 | 138 | 49895 | 51360 | 34855538 |
International normalised ratio increased | 22.17 | 11.26 | 21 | 50012 | 47306 | 34859592 |
Alanine aminotransferase increased | 22.14 | 11.26 | 52 | 49981 | 80763 | 34826135 |
Erectile dysfunction | 21.71 | 11.26 | 72 | 49961 | 20565 | 34886333 |
Muscle rigidity | 21.57 | 11.26 | 47 | 49986 | 10471 | 34896427 |
Atrial fibrillation | 21.50 | 11.26 | 96 | 49937 | 122297 | 34784601 |
Catatonia | 21.49 | 11.26 | 31 | 50002 | 4994 | 34901904 |
Death | 21.45 | 11.26 | 732 | 49301 | 397317 | 34509581 |
Post-traumatic stress disorder | 20.82 | 11.26 | 19 | 50014 | 1862 | 34905036 |
Distributive shock | 20.80 | 11.26 | 16 | 50017 | 1238 | 34905660 |
Myotonia | 20.65 | 11.26 | 6 | 50027 | 44 | 34906854 |
Bite | 20.58 | 11.26 | 7 | 50026 | 90 | 34906808 |
Alcohol interaction | 20.45 | 11.26 | 23 | 50010 | 2890 | 34904008 |
Congenital pneumonia | 20.24 | 11.26 | 7 | 50026 | 95 | 34906803 |
Painful erection | 20.21 | 11.26 | 9 | 50024 | 246 | 34906652 |
Dementia | 20.20 | 11.26 | 54 | 49979 | 13694 | 34893204 |
Depressed level of consciousness | 19.94 | 11.26 | 117 | 49916 | 42724 | 34864174 |
Illness anxiety disorder | 19.87 | 11.26 | 8 | 50025 | 169 | 34906729 |
Rash maculo-papular | 19.71 | 11.26 | 8 | 50025 | 28443 | 34878455 |
Tardive dyskinesia | 19.53 | 11.26 | 32 | 50001 | 5758 | 34901140 |
Brain injury | 19.45 | 11.26 | 33 | 50000 | 6109 | 34900789 |
Sleep sex | 19.44 | 11.26 | 4 | 50029 | 4 | 34906894 |
Poor quality sleep | 19.39 | 11.26 | 39 | 49994 | 8217 | 34898681 |
Psychomotor retardation | 19.37 | 11.26 | 25 | 50008 | 3625 | 34903273 |
Erection increased | 19.23 | 11.26 | 11 | 50022 | 516 | 34906382 |
Platelet count decreased | 19.21 | 11.26 | 97 | 49936 | 119620 | 34787278 |
Accidental overdose | 19.20 | 11.26 | 68 | 49965 | 20072 | 34886826 |
Headache | 19.19 | 11.26 | 398 | 49635 | 200237 | 34706661 |
Pulmonary congestion | 19.16 | 11.26 | 53 | 49980 | 13712 | 34893186 |
Sudden cardiac death | 19.09 | 11.26 | 25 | 50008 | 3676 | 34903222 |
Bone marrow failure | 19.04 | 11.26 | 9 | 50024 | 29244 | 34877654 |
Nervousness | 19.02 | 11.26 | 50 | 49983 | 12556 | 34894342 |
Euphoric mood | 18.79 | 11.26 | 31 | 50002 | 5610 | 34901288 |
Blood urea increased | 18.78 | 11.26 | 10 | 50023 | 30354 | 34876544 |
General symptom | 18.55 | 11.26 | 13 | 50020 | 871 | 34906027 |
Food aversion | 18.52 | 11.26 | 10 | 50023 | 419 | 34906479 |
Procedural failure | 18.41 | 11.26 | 6 | 50027 | 67 | 34906831 |
Reduced facial expression | 18.27 | 11.26 | 14 | 50019 | 1077 | 34905821 |
Lactic acidosis | 18.20 | 11.26 | 98 | 49935 | 34674 | 34872224 |
Sleep deficit | 18.17 | 11.26 | 11 | 50022 | 574 | 34906324 |
Paedophilia | 18.17 | 11.26 | 4 | 50029 | 7 | 34906891 |
C-reactive protein | 18.12 | 11.26 | 7 | 50026 | 132 | 34906766 |
Drug withdrawal syndrome | 18.09 | 11.26 | 66 | 49967 | 19768 | 34887130 |
Depersonalisation/derealisation disorder | 18.01 | 11.26 | 11 | 50022 | 583 | 34906315 |
Cholestasis | 18.00 | 11.26 | 8 | 50025 | 26940 | 34879958 |
Derealisation | 17.96 | 11.26 | 11 | 50022 | 586 | 34906312 |
Delirium febrile | 17.79 | 11.26 | 5 | 50028 | 32 | 34906866 |
Restlessness | 17.78 | 11.26 | 78 | 49955 | 25404 | 34881494 |
Bipolar disorder | 17.73 | 11.26 | 24 | 50009 | 3645 | 34903253 |
Cardiac failure | 17.61 | 11.26 | 69 | 49964 | 91179 | 34815719 |
Blood cholinesterase decreased | 17.47 | 11.26 | 7 | 50026 | 146 | 34906752 |
Device expulsion | 17.44 | 11.26 | 6 | 50027 | 80 | 34906818 |
Generalised anxiety disorder | 17.18 | 11.26 | 12 | 50021 | 800 | 34906098 |
Blood creatinine increased | 16.97 | 11.26 | 74 | 49959 | 94902 | 34811996 |
Sprue-like enteropathy | 16.85 | 11.26 | 10 | 50023 | 503 | 34906395 |
Amnesia | 16.81 | 11.26 | 79 | 49954 | 26484 | 34880414 |
Substance abuse | 16.66 | 11.26 | 35 | 49998 | 7606 | 34899292 |
Hangover | 16.54 | 11.26 | 13 | 50020 | 1038 | 34905860 |
Hypertonia | 16.44 | 11.26 | 25 | 50008 | 4221 | 34902677 |
Injection site mass | 16.41 | 11.26 | 32 | 50001 | 6594 | 34900304 |
Drug screen positive | 16.39 | 11.26 | 24 | 50009 | 3919 | 34902979 |
Product administered at inappropriate site | 16.29 | 11.26 | 18 | 50015 | 2218 | 34904680 |
Hospitalisation | 16.25 | 11.26 | 138 | 49895 | 56764 | 34850134 |
Drug reaction with eosinophilia and systemic symptoms | 16.23 | 11.26 | 14 | 50019 | 32998 | 34873900 |
Sleep-related eating disorder | 16.01 | 11.26 | 8 | 50025 | 285 | 34906613 |
Periorbital haemorrhage | 15.90 | 11.26 | 6 | 50027 | 106 | 34906792 |
Myelodysplastic syndrome | 15.79 | 11.26 | 4 | 50029 | 19204 | 34887694 |
Blood bilirubin increased | 15.70 | 11.26 | 19 | 50014 | 38277 | 34868621 |
Obsessive thoughts | 15.61 | 11.26 | 11 | 50022 | 744 | 34906154 |
Haemoglobin decreased | 15.56 | 11.26 | 105 | 49928 | 120667 | 34786231 |
Drug resistance | 15.37 | 11.26 | 9 | 50024 | 25918 | 34880980 |
Homeless | 15.23 | 11.26 | 4 | 50029 | 19 | 34906879 |
Physical disability | 15.23 | 11.26 | 14 | 50019 | 1385 | 34905513 |
Nicotine dependence | 15.14 | 11.26 | 10 | 50023 | 608 | 34906290 |
Prescription drug used without a prescription | 15.11 | 11.26 | 17 | 50016 | 2137 | 34904761 |
Sexual dysfunction | 15.07 | 11.26 | 30 | 50003 | 6273 | 34900625 |
Diabetic foetopathy | 15.06 | 11.26 | 7 | 50026 | 212 | 34906686 |
Ventricular fibrillation | 15.04 | 11.26 | 7 | 50026 | 22947 | 34883951 |
Nightmare | 14.95 | 11.26 | 50 | 49983 | 14341 | 34892557 |
Malignant neoplasm progression | 14.89 | 11.26 | 70 | 49963 | 87976 | 34818922 |
Lower respiratory tract infection | 14.86 | 11.26 | 14 | 50019 | 31623 | 34875275 |
Panic attack | 14.83 | 11.26 | 38 | 49995 | 9394 | 34897504 |
Ventricular tachycardia | 14.69 | 11.26 | 10 | 50023 | 26569 | 34880329 |
Acute myeloid leukaemia | 14.64 | 11.26 | 4 | 50029 | 18266 | 34888632 |
Aspartate aminotransferase increased | 14.57 | 11.26 | 49 | 49984 | 67734 | 34839164 |
Premature baby | 14.47 | 11.26 | 5 | 50028 | 19628 | 34887270 |
Myoclonus | 14.28 | 11.26 | 50 | 49983 | 14675 | 34892223 |
Osteonecrosis of jaw | 14.18 | 11.26 | 4 | 50029 | 17885 | 34889013 |
Urine amphetamine positive | 14.18 | 11.26 | 4 | 50029 | 26 | 34906872 |
Acute pulmonary oedema | 14.14 | 11.26 | 32 | 50001 | 7311 | 34899587 |
Multiple organ dysfunction syndrome | 14.08 | 11.26 | 59 | 49974 | 76507 | 34830391 |
Hyperhidrosis | 14.08 | 11.26 | 168 | 49865 | 75524 | 34831374 |
Discoloured vomit | 14.05 | 11.26 | 9 | 50024 | 519 | 34906379 |
Wrong patient received product | 13.80 | 11.26 | 18 | 50015 | 2636 | 34904262 |
Cardiac failure congestive | 13.62 | 11.26 | 67 | 49966 | 83203 | 34823695 |
Respiratory disorder neonatal | 13.42 | 11.26 | 14 | 50019 | 1616 | 34905282 |
Hanging | 13.34 | 11.26 | 6 | 50027 | 168 | 34906730 |
Hepatic failure | 13.25 | 11.26 | 18 | 50015 | 34513 | 34872385 |
Gambling disorder | 13.21 | 11.26 | 14 | 50019 | 1646 | 34905252 |
Leukopenia | 13.13 | 11.26 | 46 | 49987 | 62810 | 34844088 |
Pleural effusion | 13.12 | 11.26 | 66 | 49967 | 81480 | 34825418 |
Erythema | 13.09 | 11.26 | 74 | 49959 | 88706 | 34818192 |
Obsessive rumination | 13.05 | 11.26 | 3 | 50030 | 7 | 34906891 |
Memory impairment | 12.87 | 11.26 | 106 | 49927 | 43212 | 34863686 |
Infection | 12.75 | 11.26 | 77 | 49956 | 90838 | 34816060 |
Acute kidney injury | 12.68 | 11.26 | 336 | 49697 | 304652 | 34602246 |
Mental impairment | 12.68 | 11.26 | 38 | 49995 | 10284 | 34896614 |
Exposure via breast milk | 12.65 | 11.26 | 15 | 50018 | 1995 | 34904903 |
Drug use disorder | 12.59 | 11.26 | 22 | 50011 | 4169 | 34902729 |
Withdrawal catatonia | 12.54 | 11.26 | 5 | 50028 | 103 | 34906795 |
Mental disorder | 12.53 | 11.26 | 49 | 49984 | 15160 | 34891738 |
Dyspnoea | 12.49 | 11.26 | 428 | 49605 | 376354 | 34530544 |
Urine leukocyte esterase positive | 12.47 | 11.26 | 8 | 50025 | 463 | 34906435 |
Genital haemorrhage | 12.43 | 11.26 | 6 | 50027 | 198 | 34906700 |
Lung disorder | 12.42 | 11.26 | 19 | 50014 | 34677 | 34872221 |
Abnormal dreams | 12.41 | 11.26 | 31 | 50002 | 7547 | 34899351 |
Mixed delusion | 12.33 | 11.26 | 4 | 50029 | 44 | 34906854 |
Oedema peripheral | 12.24 | 11.26 | 111 | 49922 | 119701 | 34787197 |
Abnormal behaviour | 12.14 | 11.26 | 69 | 49964 | 24900 | 34881998 |
Thinking abnormal | 12.11 | 11.26 | 27 | 50006 | 6110 | 34900788 |
Pulmonary embolism | 12.07 | 11.26 | 77 | 49956 | 89669 | 34817229 |
Needle issue | 12.02 | 11.26 | 27 | 50006 | 6138 | 34900760 |
Feeling jittery | 12.01 | 11.26 | 21 | 50012 | 3982 | 34902916 |
Hyperprolactinaemia | 11.89 | 11.26 | 13 | 50020 | 1583 | 34905315 |
Eosinophilia | 11.85 | 11.26 | 12 | 50021 | 26210 | 34880688 |
Catecholamines urine increased | 11.84 | 11.26 | 3 | 50030 | 12 | 34906886 |
Back pain | 11.76 | 11.26 | 242 | 49791 | 121547 | 34785351 |
Pruritus genital | 11.54 | 11.26 | 15 | 50018 | 2189 | 34904709 |
Application site hypersensitivity | 11.53 | 11.26 | 5 | 50028 | 128 | 34906770 |
Distractibility | 11.53 | 11.26 | 7 | 50026 | 367 | 34906531 |
Tumour lysis syndrome | 11.49 | 11.26 | 5 | 50028 | 17054 | 34889844 |
Stress at work | 11.39 | 11.26 | 6 | 50027 | 239 | 34906659 |
Dehydration | 11.37 | 11.26 | 125 | 49908 | 129844 | 34777054 |
Respiratory failure | 11.35 | 11.26 | 100 | 49933 | 108472 | 34798426 |
Dry mouth | 11.32 | 11.26 | 78 | 49955 | 30087 | 34876811 |
Physiotherapy chest | 11.30 | 11.26 | 3 | 50030 | 15 | 34906883 |
Citrobacter test positive | 11.30 | 11.26 | 3 | 50030 | 15 | 34906883 |
Prostate cancer | 11.27 | 11.26 | 25 | 50008 | 39624 | 34867274 |
Toxicologic test abnormal | 11.26 | 11.26 | 8 | 50025 | 548 | 34906350 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1691.93 | 10.15 | 2159 | 143412 | 243608 | 79355209 |
Serotonin syndrome | 785.72 | 10.15 | 654 | 144917 | 44373 | 79554444 |
Toxicity to various agents | 766.76 | 10.15 | 2083 | 143488 | 419457 | 79179360 |
Sopor | 753.99 | 10.15 | 562 | 145009 | 32448 | 79566369 |
Drug abuse | 735.14 | 10.15 | 1171 | 144400 | 161520 | 79437297 |
Priapism | 386.88 | 10.15 | 181 | 145390 | 4324 | 79594493 |
Suicide attempt | 307.60 | 10.15 | 547 | 145024 | 82385 | 79516432 |
Polycystic ovaries | 291.42 | 10.15 | 141 | 145430 | 3638 | 79595179 |
Cardio-respiratory arrest | 228.91 | 10.15 | 568 | 145003 | 107942 | 79490875 |
Sensitisation | 218.14 | 10.15 | 111 | 145460 | 3200 | 79595617 |
Overdose | 212.39 | 10.15 | 779 | 144792 | 183427 | 79415390 |
Suicidal ideation | 211.34 | 10.15 | 445 | 145126 | 75895 | 79522922 |
Drug interaction | 202.04 | 10.15 | 1373 | 144198 | 413810 | 79185007 |
Rhinitis allergic | 190.99 | 10.15 | 167 | 145404 | 12102 | 79586715 |
Intentional overdose | 178.22 | 10.15 | 510 | 145061 | 105450 | 79493367 |
Hypomania | 173.42 | 10.15 | 129 | 145442 | 7415 | 79591402 |
Ejection fraction | 172.97 | 10.15 | 84 | 145487 | 2185 | 79596632 |
Hand deformity | 166.64 | 10.15 | 5 | 145566 | 103914 | 79494903 |
Pemphigus | 166.58 | 10.15 | 3 | 145568 | 99579 | 79499238 |
Electrocardiogram QT prolonged | 158.80 | 10.15 | 442 | 145129 | 89944 | 79508873 |
Sleep disorder due to a general medical condition | 156.47 | 10.15 | 160 | 145411 | 14117 | 79584700 |
Blood test abnormal | 156.33 | 10.15 | 177 | 145394 | 17533 | 79581284 |
Withdrawal syndrome | 135.98 | 10.15 | 204 | 145367 | 26650 | 79572167 |
Pericarditis | 134.77 | 10.15 | 16 | 145555 | 104220 | 79494597 |
Gastrooesophageal reflux disease | 133.92 | 10.15 | 457 | 145114 | 103789 | 79495028 |
Febrile neutropenia | 122.16 | 10.15 | 145 | 145426 | 230854 | 79367963 |
Systemic lupus erythematosus | 119.92 | 10.15 | 36 | 145535 | 121113 | 79477704 |
Maternal exposure during pregnancy | 119.06 | 10.15 | 50 | 145521 | 136488 | 79462329 |
Presbyacusis | 118.99 | 10.15 | 69 | 145502 | 2591 | 79596226 |
Carpal tunnel syndrome | 118.96 | 10.15 | 162 | 145409 | 19366 | 79579451 |
Psychotic disorder | 118.82 | 10.15 | 245 | 145326 | 41157 | 79557660 |
Agitation | 115.91 | 10.15 | 423 | 145148 | 99292 | 79499525 |
Schizophrenia | 114.23 | 10.15 | 141 | 145430 | 15299 | 79583518 |
Migraine | 111.87 | 10.15 | 383 | 145188 | 87110 | 79511707 |
Pancytopenia | 109.81 | 10.15 | 85 | 145486 | 165660 | 79433157 |
Swelling | 109.36 | 10.15 | 141 | 145430 | 216570 | 79382247 |
Thrombocytopenia | 108.54 | 10.15 | 199 | 145372 | 265060 | 79333757 |
Sleep apnoea syndrome | 107.21 | 10.15 | 218 | 145353 | 36260 | 79562557 |
Pyrexia | 103.00 | 10.15 | 771 | 144800 | 677938 | 78920879 |
Wound | 102.17 | 10.15 | 42 | 145529 | 116137 | 79482680 |
General physical health deterioration | 101.86 | 10.15 | 219 | 145352 | 275019 | 79323798 |
Insomnia | 101.78 | 10.15 | 781 | 144790 | 244389 | 79354428 |
Glossodynia | 101.74 | 10.15 | 31 | 145540 | 103306 | 79495511 |
Jaundice cholestatic | 98.27 | 10.15 | 112 | 145459 | 11172 | 79587645 |
Anaemia | 98.19 | 10.15 | 448 | 145123 | 444567 | 79154250 |
Pleural thickening | 96.72 | 10.15 | 63 | 145508 | 2919 | 79595898 |
Depression | 94.71 | 10.15 | 699 | 144872 | 216091 | 79382726 |
Lung diffusion test abnormal | 94.31 | 10.15 | 33 | 145538 | 357 | 79598460 |
Neutropenia | 93.66 | 10.15 | 245 | 145326 | 287465 | 79311352 |
Pleural fibrosis | 92.98 | 10.15 | 70 | 145501 | 4097 | 79594720 |
Anxiety | 90.84 | 10.15 | 769 | 144802 | 247743 | 79351074 |
Blood magnesium increased | 89.78 | 10.15 | 64 | 145507 | 3442 | 79595375 |
Helicobacter infection | 89.36 | 10.15 | 11 | 145560 | 69693 | 79529124 |
Loss of personal independence in daily activities | 87.24 | 10.15 | 395 | 145176 | 102185 | 79496632 |
Rash | 87.20 | 10.15 | 658 | 144913 | 577700 | 79021117 |
Tremor | 87.00 | 10.15 | 570 | 145001 | 169513 | 79429304 |
Product dose omission issue | 86.82 | 10.15 | 759 | 144812 | 246778 | 79352039 |
Bradyphrenia | 84.96 | 10.15 | 101 | 145470 | 10539 | 79588278 |
Respiratory arrest | 84.41 | 10.15 | 264 | 145307 | 57286 | 79541531 |
Folliculitis | 84.21 | 10.15 | 4 | 145567 | 55376 | 79543441 |
Suspected suicide | 83.80 | 10.15 | 100 | 145471 | 10476 | 79588341 |
Exposure during pregnancy | 80.50 | 10.15 | 42 | 145529 | 101090 | 79497727 |
Synovitis | 79.24 | 10.15 | 95 | 145476 | 150639 | 79448178 |
Intentional self-injury | 78.35 | 10.15 | 179 | 145392 | 32240 | 79566577 |
Hyperreflexia | 76.05 | 10.15 | 85 | 145486 | 8300 | 79590517 |
Somnolence | 74.77 | 10.15 | 715 | 144856 | 238266 | 79360551 |
Mucosal inflammation | 72.04 | 10.15 | 24 | 145547 | 75556 | 79523261 |
C-reactive protein abnormal | 71.94 | 10.15 | 4 | 145567 | 48363 | 79550454 |
Infusion related reaction | 71.93 | 10.15 | 200 | 145371 | 230037 | 79368780 |
Intrusive thoughts | 70.90 | 10.15 | 29 | 145542 | 495 | 79598322 |
Mental status changes | 68.68 | 10.15 | 273 | 145298 | 66686 | 79532131 |
Ejection fraction abnormal | 68.21 | 10.15 | 47 | 145524 | 2393 | 79596424 |
Impaired healing | 67.43 | 10.15 | 38 | 145533 | 87617 | 79511200 |
Irritability | 67.16 | 10.15 | 196 | 145375 | 40948 | 79557869 |
Haemoglobin decreased | 67.14 | 10.15 | 196 | 145375 | 221923 | 79376894 |
Joint swelling | 66.97 | 10.15 | 285 | 145286 | 288361 | 79310456 |
Muscle injury | 66.51 | 10.15 | 6 | 145565 | 48555 | 79550262 |
Memory impairment | 66.23 | 10.15 | 389 | 145182 | 111345 | 79487472 |
Deafness neurosensory | 66.14 | 10.15 | 72 | 145499 | 6826 | 79591991 |
Poor quality sleep | 65.82 | 10.15 | 135 | 145436 | 22587 | 79576230 |
Neovascularisation | 65.73 | 10.15 | 36 | 145535 | 1209 | 79597608 |
Renal failure | 65.47 | 10.15 | 171 | 145400 | 200797 | 79398020 |
Head discomfort | 64.79 | 10.15 | 104 | 145467 | 14398 | 79584419 |
Asthma | 64.41 | 10.15 | 445 | 145126 | 134650 | 79464167 |
Nephrectomy | 62.11 | 10.15 | 42 | 145529 | 2073 | 79596744 |
Malignant neoplasm progression | 62.08 | 10.15 | 95 | 145476 | 135895 | 79462922 |
Hyper IgE syndrome | 61.91 | 10.15 | 27 | 145544 | 544 | 79598273 |
Akathisia | 61.88 | 10.15 | 97 | 145474 | 13162 | 79585655 |
Platelet count decreased | 61.62 | 10.15 | 168 | 145403 | 194496 | 79404321 |
Acute kidney injury | 60.96 | 10.15 | 630 | 144941 | 518774 | 79080043 |
Myocardial stunning | 59.95 | 10.15 | 20 | 145551 | 185 | 79598632 |
Disease progression | 58.43 | 10.15 | 159 | 145412 | 184203 | 79414614 |
Tachyphrenia | 57.99 | 10.15 | 40 | 145531 | 2040 | 79596777 |
Burning sensation | 57.70 | 10.15 | 236 | 145335 | 58396 | 79540421 |
Alopecia | 56.42 | 10.15 | 224 | 145347 | 231131 | 79367686 |
Accidental poisoning | 56.19 | 10.15 | 36 | 145535 | 1621 | 79597196 |
Confabulation | 55.47 | 10.15 | 24 | 145547 | 474 | 79598343 |
Epigastric discomfort | 55.05 | 10.15 | 70 | 145501 | 7826 | 79590991 |
Headache | 55.04 | 10.15 | 1572 | 143999 | 652200 | 78946617 |
Cardiac failure | 54.94 | 10.15 | 126 | 145445 | 154716 | 79444101 |
Alcoholism | 54.60 | 10.15 | 49 | 145522 | 3674 | 79595143 |
Sedation | 54.36 | 10.15 | 213 | 145358 | 51682 | 79547135 |
Blepharospasm | 52.53 | 10.15 | 59 | 145512 | 5792 | 79593025 |
Sputum discoloured | 52.48 | 10.15 | 120 | 145451 | 21623 | 79577194 |
Cholestasis | 52.44 | 10.15 | 15 | 145556 | 52094 | 79546723 |
Septic shock | 51.19 | 10.15 | 91 | 145480 | 122710 | 79476107 |
Bone marrow failure | 50.90 | 10.15 | 15 | 145556 | 51092 | 79547725 |
Stomatitis | 50.80 | 10.15 | 121 | 145450 | 146636 | 79452181 |
Injection site mass | 50.50 | 10.15 | 113 | 145458 | 20071 | 79578746 |
Total lung capacity increased | 49.94 | 10.15 | 38 | 145533 | 2260 | 79596557 |
Leukopenia | 49.79 | 10.15 | 85 | 145486 | 116428 | 79482389 |
Homicidal ideation | 49.72 | 10.15 | 45 | 145526 | 3412 | 79595405 |
Cytomegalovirus infection | 49.44 | 10.15 | 9 | 145562 | 42635 | 79556182 |
Blister | 49.39 | 10.15 | 89 | 145482 | 119387 | 79479430 |
Paradoxical drug reaction | 48.99 | 10.15 | 63 | 145508 | 7122 | 79591695 |
Nightmare | 48.92 | 10.15 | 130 | 145441 | 25731 | 79573086 |
Restless legs syndrome | 48.61 | 10.15 | 111 | 145460 | 19981 | 79578836 |
Clonus | 48.26 | 10.15 | 61 | 145510 | 6779 | 79592038 |
Sepsis | 48.25 | 10.15 | 291 | 145280 | 269137 | 79329680 |
Extrapyramidal disorder | 48.07 | 10.15 | 119 | 145452 | 22560 | 79576257 |
Hepatic function abnormal | 47.75 | 10.15 | 38 | 145533 | 73069 | 79525748 |
Adjustment disorder with mixed anxiety and depressed mood | 47.55 | 10.15 | 15 | 145556 | 114 | 79598703 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 46.46 | 10.15 | 42 | 145529 | 3179 | 79595638 |
Fall | 46.23 | 10.15 | 1191 | 144380 | 486438 | 79112379 |
Contraindicated product administered | 46.16 | 10.15 | 141 | 145430 | 157397 | 79441420 |
Delirium | 45.93 | 10.15 | 288 | 145283 | 84339 | 79514478 |
Cyst | 45.85 | 10.15 | 87 | 145484 | 13753 | 79585064 |
Aggression | 45.39 | 10.15 | 199 | 145372 | 50759 | 79548058 |
Visual perseveration | 45.18 | 10.15 | 13 | 145558 | 69 | 79598748 |
Intentional product misuse | 45.07 | 10.15 | 313 | 145258 | 94852 | 79503965 |
Drug withdrawal syndrome | 44.37 | 10.15 | 152 | 145419 | 34566 | 79564251 |
Lower respiratory tract infection | 44.36 | 10.15 | 107 | 145464 | 129113 | 79469704 |
Depressed level of consciousness | 44.08 | 10.15 | 315 | 145256 | 96337 | 79502480 |
Hallucination, auditory | 43.25 | 10.15 | 108 | 145463 | 20585 | 79578232 |
Analgesic drug level above therapeutic | 43.08 | 10.15 | 20 | 145551 | 469 | 79598348 |
Anger | 42.85 | 10.15 | 96 | 145475 | 17066 | 79581751 |
Penis injury | 42.21 | 10.15 | 14 | 145557 | 127 | 79598690 |
Interstitial lung disease | 41.27 | 10.15 | 90 | 145481 | 112510 | 79486307 |
Hospitalisation | 41.18 | 10.15 | 304 | 145267 | 93932 | 79504885 |
Irritable bowel syndrome | 41.09 | 10.15 | 32 | 145539 | 62209 | 79536608 |
Muscle rigidity | 40.75 | 10.15 | 103 | 145468 | 19779 | 79579038 |
Psychomotor hyperactivity | 40.67 | 10.15 | 93 | 145478 | 16756 | 79582061 |
Environmental exposure | 40.33 | 10.15 | 18 | 145553 | 384 | 79598433 |
Multiple organ dysfunction syndrome | 40.15 | 10.15 | 101 | 145470 | 120145 | 79478672 |
Sleep disorder | 40.10 | 10.15 | 281 | 145290 | 85396 | 79513421 |
Antidepressant drug level above therapeutic | 39.76 | 10.15 | 21 | 145550 | 655 | 79598162 |
Persistent genital arousal disorder | 39.56 | 10.15 | 16 | 145555 | 265 | 79598552 |
Toxic epidermal necrolysis | 39.37 | 10.15 | 16 | 145555 | 44565 | 79554252 |
Abdominal discomfort | 39.23 | 10.15 | 282 | 145289 | 250445 | 79348372 |
Drug resistance | 39.20 | 10.15 | 14 | 145557 | 42199 | 79556618 |
Arthropathy | 39.15 | 10.15 | 178 | 145393 | 176933 | 79421884 |
Hostility | 39.12 | 10.15 | 33 | 145538 | 2277 | 79596540 |
Liver disorder | 38.73 | 10.15 | 45 | 145526 | 72372 | 79526445 |
Bone cyst | 38.57 | 10.15 | 39 | 145532 | 3394 | 79595423 |
Oral discomfort | 38.25 | 10.15 | 66 | 145505 | 9694 | 79589123 |
Tardive dyskinesia | 38.22 | 10.15 | 69 | 145502 | 10502 | 79588315 |
Neuroleptic malignant syndrome | 38.19 | 10.15 | 124 | 145447 | 27435 | 79571382 |
Prescription drug used without a prescription | 38.06 | 10.15 | 42 | 145529 | 4043 | 79594774 |
Cardiac failure congestive | 37.88 | 10.15 | 133 | 145438 | 142269 | 79456548 |
Fibromyalgia | 37.47 | 10.15 | 223 | 145348 | 64117 | 79534700 |
International normalised ratio increased | 36.94 | 10.15 | 61 | 145510 | 84660 | 79514157 |
Body tinea | 36.68 | 10.15 | 29 | 145542 | 1825 | 79596992 |
Reduced facial expression | 35.91 | 10.15 | 34 | 145537 | 2731 | 79596086 |
Rash maculo-papular | 35.57 | 10.15 | 30 | 145541 | 56048 | 79542769 |
Hypersensitivity | 35.43 | 10.15 | 307 | 145264 | 261932 | 79336885 |
Abnormal behaviour | 35.35 | 10.15 | 146 | 145425 | 36275 | 79562542 |
Hypertonia | 35.27 | 10.15 | 54 | 145517 | 7178 | 79591639 |
Dry eye | 35.03 | 10.15 | 147 | 145424 | 36784 | 79562033 |
Multiple sclerosis relapse | 35.03 | 10.15 | 173 | 145398 | 46360 | 79552457 |
Drug screen positive | 34.97 | 10.15 | 49 | 145522 | 6014 | 79592803 |
Drug intolerance | 34.89 | 10.15 | 311 | 145260 | 263808 | 79335009 |
Libido increased | 34.74 | 10.15 | 29 | 145542 | 1972 | 79596845 |
Total lung capacity decreased | 34.48 | 10.15 | 34 | 145537 | 2871 | 79595946 |
Infection | 34.44 | 10.15 | 279 | 145292 | 241433 | 79357384 |
Lung disorder | 34.20 | 10.15 | 59 | 145512 | 80498 | 79518319 |
Initial insomnia | 34.12 | 10.15 | 52 | 145519 | 6886 | 79591931 |
Nervousness | 34.06 | 10.15 | 136 | 145435 | 33279 | 79565538 |
Osteosclerosis | 33.88 | 10.15 | 39 | 145532 | 3932 | 79594885 |
Osteopenia | 33.41 | 10.15 | 91 | 145480 | 18273 | 79580544 |
Pneumocystis jirovecii pneumonia | 33.38 | 10.15 | 9 | 145562 | 32499 | 79566318 |
Cardiac disorder | 33.35 | 10.15 | 220 | 145351 | 65537 | 79533280 |
Myelosuppression | 33.16 | 10.15 | 16 | 145555 | 40280 | 79558537 |
Somatic delusion | 33.12 | 10.15 | 19 | 145552 | 699 | 79598118 |
Hepatic failure | 32.77 | 10.15 | 38 | 145533 | 61174 | 79537643 |
Sinus bradycardia | 32.67 | 10.15 | 111 | 145460 | 25136 | 79573681 |
Accidental overdose | 32.58 | 10.15 | 151 | 145420 | 39430 | 79559387 |
Cardiac murmur | 32.45 | 10.15 | 82 | 145489 | 15742 | 79583075 |
Mental disorder | 32.39 | 10.15 | 128 | 145443 | 31174 | 79567643 |
Neck pain | 32.21 | 10.15 | 242 | 145329 | 75175 | 79523642 |
Parkinsonism | 32.01 | 10.15 | 84 | 145487 | 16500 | 79582317 |
Anaphylactic shock | 31.66 | 10.15 | 13 | 145558 | 35983 | 79562834 |
Wheezing | 31.61 | 10.15 | 339 | 145232 | 116325 | 79482492 |
Pleurothotonus | 30.90 | 10.15 | 30 | 145541 | 2486 | 79596331 |
Alanine aminotransferase increased | 30.46 | 10.15 | 173 | 145398 | 162397 | 79436420 |
Discomfort | 30.36 | 10.15 | 122 | 145449 | 125495 | 79473322 |
Restlessness | 30.26 | 10.15 | 166 | 145405 | 46326 | 79552491 |
Dissociation | 30.19 | 10.15 | 37 | 145534 | 3984 | 79594833 |
Cardiac arrest | 29.64 | 10.15 | 460 | 145111 | 171636 | 79427181 |
Ejection fraction decreased | 29.59 | 10.15 | 13 | 145558 | 34564 | 79564253 |
Hepatocellular injury | 29.53 | 10.15 | 26 | 145545 | 47567 | 79551250 |
Hypothyroidism | 29.49 | 10.15 | 180 | 145391 | 52212 | 79546605 |
Skin lesion | 29.00 | 10.15 | 152 | 145419 | 41692 | 79557125 |
Therapeutic product effect decreased | 28.78 | 10.15 | 178 | 145393 | 163685 | 79435132 |
Asphyxia | 28.63 | 10.15 | 65 | 145506 | 11655 | 79587162 |
Restrictive pulmonary disease | 28.28 | 10.15 | 29 | 145542 | 2566 | 79596251 |
Concussion | 28.16 | 10.15 | 57 | 145514 | 9446 | 79589371 |
Autonomic nervous system imbalance | 27.58 | 10.15 | 38 | 145533 | 4592 | 79594225 |
Infection susceptibility increased | 27.55 | 10.15 | 34 | 145537 | 3687 | 79595130 |
Loss of libido | 27.46 | 10.15 | 29 | 145542 | 2656 | 79596161 |
Cognitive disorder | 27.44 | 10.15 | 220 | 145351 | 69706 | 79529111 |
Disorganised speech | 27.43 | 10.15 | 26 | 145545 | 2091 | 79596726 |
Acute myeloid leukaemia | 27.41 | 10.15 | 11 | 145560 | 30874 | 79567943 |
Mood swings | 27.14 | 10.15 | 89 | 145482 | 19791 | 79579026 |
Coagulopathy | 27.13 | 10.15 | 16 | 145555 | 35990 | 79562827 |
Penile haemorrhage | 26.90 | 10.15 | 15 | 145556 | 522 | 79598295 |
Listless | 26.55 | 10.15 | 34 | 145537 | 3827 | 79594990 |
Abnormal dreams | 26.46 | 10.15 | 62 | 145509 | 11350 | 79587467 |
Taste disorder | 26.42 | 10.15 | 76 | 145495 | 15747 | 79583070 |
Drug reaction with eosinophilia and systemic symptoms | 26.41 | 10.15 | 48 | 145523 | 64196 | 79534621 |
Symptom masked | 25.92 | 10.15 | 21 | 145550 | 1369 | 79597448 |
Urticaria | 25.81 | 10.15 | 215 | 145356 | 184986 | 79413831 |
Post-traumatic neck syndrome | 25.77 | 10.15 | 25 | 145546 | 2069 | 79596748 |
Depressed mood | 25.69 | 10.15 | 164 | 145407 | 48316 | 79550501 |
Sleep disorder due to general medical condition, insomnia type | 25.60 | 10.15 | 25 | 145546 | 43531 | 79555286 |
Ascites | 25.59 | 10.15 | 63 | 145508 | 75499 | 79523318 |
Dysphoria | 25.45 | 10.15 | 37 | 145534 | 4697 | 79594120 |
Therapy non-responder | 25.36 | 10.15 | 85 | 145486 | 92220 | 79506597 |
Substance abuse | 25.30 | 10.15 | 58 | 145513 | 10468 | 79588349 |
Angioedema | 25.27 | 10.15 | 64 | 145507 | 75971 | 79522846 |
Soft tissue injury | 25.25 | 10.15 | 23 | 145548 | 1758 | 79597059 |
Delusion of replacement | 25.10 | 10.15 | 10 | 145561 | 159 | 79598658 |
Vasoplegia syndrome | 25.02 | 10.15 | 32 | 145539 | 3598 | 79595219 |
Renal impairment | 24.89 | 10.15 | 177 | 145394 | 157606 | 79441211 |
Hereditary angioedema | 24.85 | 10.15 | 39 | 145532 | 5296 | 79593521 |
Hyperkalaemia | 24.66 | 10.15 | 116 | 145455 | 114282 | 79484535 |
Injection site reaction | 24.65 | 10.15 | 178 | 145393 | 54607 | 79544210 |
Gambling disorder | 24.58 | 10.15 | 24 | 145547 | 2002 | 79596815 |
Bronchopulmonary aspergillosis allergic | 24.34 | 10.15 | 29 | 145542 | 3032 | 79595785 |
Feeling abnormal | 24.24 | 10.15 | 417 | 145154 | 158782 | 79440035 |
Haematocrit decreased | 24.16 | 10.15 | 47 | 145524 | 61265 | 79537552 |
Gastrointestinal haemorrhage | 24.14 | 10.15 | 164 | 145407 | 147555 | 79451262 |
Vertigo | 23.74 | 10.15 | 211 | 145360 | 68871 | 79529946 |
Arteriosclerosis coronary artery | 23.64 | 10.15 | 79 | 145492 | 17737 | 79581080 |
Jaundice | 23.64 | 10.15 | 38 | 145533 | 53311 | 79545506 |
Mood altered | 23.56 | 10.15 | 79 | 145492 | 17768 | 79581049 |
Sternal fracture | 23.55 | 10.15 | 26 | 145545 | 2504 | 79596313 |
Hyperhidrosis | 23.50 | 10.15 | 398 | 145173 | 151094 | 79447723 |
Liver function test abnormal | 23.24 | 10.15 | 52 | 145519 | 64423 | 79534394 |
Sense of a foreshortened future | 23.08 | 10.15 | 5 | 145566 | 5 | 79598812 |
Ill-defined disorder | 23.04 | 10.15 | 54 | 145517 | 65821 | 79532996 |
Obstructive airways disorder | 23.00 | 10.15 | 116 | 145455 | 31343 | 79567474 |
Disseminated intravascular coagulation | 22.94 | 10.15 | 19 | 145552 | 35823 | 79562994 |
Hip arthroplasty | 22.83 | 10.15 | 19 | 145552 | 35737 | 79563080 |
Cerebral infarction | 22.72 | 10.15 | 30 | 145541 | 45646 | 79553171 |
Encephalopathy | 22.72 | 10.15 | 205 | 145366 | 67192 | 79531625 |
Aplastic anaemia | 22.52 | 10.15 | 3 | 145568 | 17902 | 79580915 |
Confusional state | 22.48 | 10.15 | 749 | 144822 | 317248 | 79281569 |
Myoclonus | 22.38 | 10.15 | 105 | 145466 | 27555 | 79571262 |
Tonic clonic movements | 22.35 | 10.15 | 24 | 145547 | 2240 | 79596577 |
Economic problem | 22.30 | 10.15 | 24 | 145547 | 2246 | 79596571 |
Dyskinesia | 22.22 | 10.15 | 149 | 145422 | 44624 | 79554193 |
Aspartate aminotransferase increased | 22.12 | 10.15 | 155 | 145416 | 138486 | 79460331 |
Impaired quality of life | 22.02 | 10.15 | 67 | 145504 | 14319 | 79584498 |
Psychomotor retardation | 21.90 | 10.15 | 40 | 145531 | 6144 | 79592673 |
Unresponsive to stimuli | 21.60 | 10.15 | 175 | 145396 | 55613 | 79543204 |
Dermatitis atopic | 21.56 | 10.15 | 53 | 145518 | 10003 | 79588814 |
Atrial fibrillation | 21.55 | 10.15 | 244 | 145327 | 197642 | 79401175 |
Solar urticaria | 21.47 | 10.15 | 8 | 145563 | 105 | 79598712 |
Cholelithiasis | 21.38 | 10.15 | 167 | 145404 | 52497 | 79546320 |
Apathy | 21.35 | 10.15 | 62 | 145509 | 12915 | 79585902 |
Blood lactate dehydrogenase increased | 21.31 | 10.15 | 24 | 145547 | 39146 | 79559671 |
Epistaxis | 21.25 | 10.15 | 118 | 145453 | 111397 | 79487420 |
Meningitis streptococcal | 21.22 | 10.15 | 9 | 145562 | 169 | 79598648 |
Bronchiectasis | 21.15 | 10.15 | 89 | 145482 | 22297 | 79576520 |
Periorbital swelling | 20.70 | 10.15 | 26 | 145545 | 2870 | 79595947 |
Haemophagocytic lymphohistiocytosis | 20.69 | 10.15 | 7 | 145564 | 21830 | 79576987 |
Neuropathy peripheral | 20.62 | 10.15 | 162 | 145409 | 141143 | 79457674 |
Blood urea increased | 20.46 | 10.15 | 36 | 145535 | 48754 | 79550063 |
Polymerase chain reaction | 20.32 | 10.15 | 8 | 145563 | 123 | 79598694 |
Lung opacity | 20.29 | 10.15 | 35 | 145536 | 5139 | 79593678 |
Bronchospasm | 20.26 | 10.15 | 10 | 145561 | 24849 | 79573968 |
C-reactive protein increased | 20.22 | 10.15 | 145 | 145426 | 128882 | 79469935 |
Homicide | 20.20 | 10.15 | 17 | 145554 | 1169 | 79597648 |
White blood cell count decreased | 20.17 | 10.15 | 233 | 145338 | 188055 | 79410762 |
Euphoric mood | 20.17 | 10.15 | 44 | 145527 | 7682 | 79591135 |
Sarcoidosis | 20.11 | 10.15 | 46 | 145525 | 8289 | 79590528 |
Erection increased | 20.09 | 10.15 | 11 | 145560 | 369 | 79598448 |
Heart rate abnormal | 19.97 | 10.15 | 38 | 145533 | 6019 | 79592798 |
Major depression | 19.97 | 10.15 | 48 | 145523 | 8932 | 79589885 |
Death | 19.95 | 10.15 | 1243 | 144328 | 565271 | 79033546 |
Thrombotic microangiopathy | 19.94 | 10.15 | 6 | 145565 | 20163 | 79578654 |
Premature delivery | 19.80 | 10.15 | 9 | 145562 | 23458 | 79575359 |
Joint range of motion decreased | 19.68 | 10.15 | 19 | 145552 | 33263 | 79565554 |
Prostate cancer | 19.66 | 10.15 | 19 | 145552 | 33249 | 79565568 |
Live birth | 19.60 | 10.15 | 5 | 145566 | 18739 | 79580078 |
Dementia | 19.51 | 10.15 | 93 | 145478 | 24566 | 79574251 |
Nasal polyps | 19.44 | 10.15 | 42 | 145529 | 7285 | 79591532 |
Blood cholesterol increased | 19.18 | 10.15 | 83 | 145488 | 83637 | 79515180 |
Post-traumatic stress disorder | 19.12 | 10.15 | 33 | 145538 | 4848 | 79593969 |
Blood calcium decreased | 19.00 | 10.15 | 18 | 145553 | 31801 | 79567016 |
Paranoia | 18.94 | 10.15 | 78 | 145493 | 19354 | 79579463 |
Discoloured vomit | 18.86 | 10.15 | 18 | 145553 | 1460 | 79597357 |
Apallic syndrome | 18.85 | 10.15 | 15 | 145556 | 953 | 79597864 |
Hallucination, visual | 18.77 | 10.15 | 113 | 145458 | 32616 | 79566201 |
Cardiomyopathy | 18.73 | 10.15 | 15 | 145556 | 28759 | 79570058 |
Sensation of foreign body | 18.65 | 10.15 | 35 | 145536 | 5487 | 79593330 |
Inhibitory drug interaction | 18.63 | 10.15 | 31 | 145540 | 4422 | 79594395 |
Aspergillus infection | 18.40 | 10.15 | 6 | 145565 | 19155 | 79579662 |
Eye haematoma | 18.40 | 10.15 | 8 | 145563 | 160 | 79598657 |
Bursitis | 18.39 | 10.15 | 23 | 145548 | 35821 | 79562996 |
Palmar-plantar erythrodysaesthesia syndrome | 18.36 | 10.15 | 20 | 145551 | 33114 | 79565703 |
Myelodysplastic syndrome | 18.26 | 10.15 | 17 | 145554 | 30284 | 79568533 |
Hypokinesia | 18.18 | 10.15 | 76 | 145495 | 18984 | 79579833 |
Painful erection | 18.17 | 10.15 | 8 | 145563 | 165 | 79598652 |
Blood potassium increased | 18.03 | 10.15 | 103 | 145468 | 29172 | 79569645 |
Full blood count abnormal | 17.92 | 10.15 | 131 | 145440 | 40343 | 79558474 |
Skin texture abnormal | 17.88 | 10.15 | 11 | 145560 | 461 | 79598356 |
Hepatitis | 17.69 | 10.15 | 48 | 145523 | 55679 | 79543138 |
Middle insomnia | 17.68 | 10.15 | 67 | 145504 | 16002 | 79582815 |
Neutrophil count decreased | 17.58 | 10.15 | 100 | 145471 | 93859 | 79504958 |
Purple glove syndrome | 17.57 | 10.15 | 9 | 145562 | 263 | 79598554 |
Grip strength decreased | 17.52 | 10.15 | 9 | 145562 | 21860 | 79576957 |
Psychomotor skills impaired | 17.45 | 10.15 | 33 | 145538 | 5204 | 79593613 |
Needle issue | 17.39 | 10.15 | 58 | 145513 | 13010 | 79585807 |
Disorientation | 17.27 | 10.15 | 183 | 145388 | 62593 | 79536224 |
Generalised oedema | 17.22 | 10.15 | 11 | 145560 | 23698 | 79575119 |
Muscle twitching | 17.19 | 10.15 | 90 | 145481 | 24674 | 79574143 |
Body height decreased | 17.11 | 10.15 | 44 | 145527 | 8536 | 79590281 |
Device dislocation | 17.08 | 10.15 | 93 | 145478 | 25877 | 79572940 |
Pleural effusion | 17.06 | 10.15 | 176 | 145395 | 145086 | 79453731 |
Breath sounds abnormal | 17.05 | 10.15 | 66 | 145505 | 15918 | 79582899 |
Device malfunction | 17.04 | 10.15 | 81 | 145490 | 21367 | 79577450 |
Perseveration | 16.97 | 10.15 | 10 | 145561 | 387 | 79598430 |
Bipolar disorder | 16.93 | 10.15 | 41 | 145530 | 7666 | 79591151 |
Maximal voluntary ventilation abnormal | 16.73 | 10.15 | 5 | 145566 | 31 | 79598786 |
Exostosis | 16.69 | 10.15 | 68 | 145503 | 16790 | 79582027 |
Mental impairment | 16.69 | 10.15 | 74 | 145497 | 18962 | 79579855 |
Bronchopulmonary aspergillosis | 16.67 | 10.15 | 10 | 145561 | 22284 | 79576533 |
Proteinuria | 16.53 | 10.15 | 21 | 145550 | 32481 | 79566336 |
Dehydration | 16.37 | 10.15 | 337 | 145234 | 247850 | 79350967 |
Burning mouth syndrome | 16.28 | 10.15 | 11 | 145560 | 542 | 79598275 |
Wound infection fungal | 16.20 | 10.15 | 8 | 145563 | 216 | 79598601 |
Abortion spontaneous | 16.14 | 10.15 | 18 | 145553 | 29489 | 79569328 |
Galactorrhoea | 16.09 | 10.15 | 26 | 145545 | 3620 | 79595197 |
Alcohol withdrawal syndrome | 15.91 | 10.15 | 19 | 145552 | 1992 | 79596825 |
Coma | 15.81 | 10.15 | 265 | 145306 | 100384 | 79498433 |
Product administered at inappropriate site | 15.79 | 10.15 | 27 | 145544 | 3938 | 79594879 |
Mydriasis | 15.79 | 10.15 | 69 | 145502 | 17574 | 79581243 |
Procedural failure | 15.75 | 10.15 | 6 | 145565 | 84 | 79598733 |
Heterophoria | 15.74 | 10.15 | 5 | 145566 | 39 | 79598778 |
Oedema | 15.68 | 10.15 | 141 | 145430 | 119439 | 79479378 |
Dyspnoea exertional | 15.59 | 10.15 | 94 | 145477 | 86979 | 79511838 |
Accidental death | 15.50 | 10.15 | 28 | 145543 | 4263 | 79594554 |
Osteonecrosis of jaw | 15.46 | 10.15 | 35 | 145536 | 43191 | 79555626 |
Thinking abnormal | 15.42 | 10.15 | 56 | 145515 | 13105 | 79585712 |
Toxic skin eruption | 15.31 | 10.15 | 11 | 145560 | 22282 | 79576535 |
Injection site induration | 15.28 | 10.15 | 46 | 145525 | 9773 | 79589044 |
Renal disorder | 15.19 | 10.15 | 130 | 145441 | 41975 | 79556842 |
Rheumatoid factor positive | 15.17 | 10.15 | 57 | 145514 | 59782 | 79539035 |
Product packaging difficult to open | 15.11 | 10.15 | 5 | 145566 | 45 | 79598772 |
Compulsive sexual behaviour | 15.02 | 10.15 | 8 | 145563 | 254 | 79598563 |
Obsessive thoughts | 14.85 | 10.15 | 14 | 145557 | 1118 | 79597699 |
Deep vein thrombosis | 14.82 | 10.15 | 145 | 145426 | 120774 | 79478043 |
Knee arthroplasty | 14.69 | 10.15 | 36 | 145535 | 43212 | 79555605 |
Haematotoxicity | 14.66 | 10.15 | 5 | 145566 | 15514 | 79583303 |
Obsessive-compulsive disorder | 14.62 | 10.15 | 33 | 145538 | 5894 | 79592923 |
Chronic obstructive pulmonary disease | 14.57 | 10.15 | 228 | 145343 | 85191 | 79513626 |
Sinusitis | 14.57 | 10.15 | 260 | 145311 | 195241 | 79403576 |
Catatonia | 14.56 | 10.15 | 42 | 145529 | 8714 | 79590103 |
Pulmonary embolism | 14.53 | 10.15 | 223 | 145348 | 171431 | 79427386 |
Urine odour abnormal | 14.45 | 10.15 | 34 | 145537 | 6239 | 79592578 |
Hypogammaglobulinaemia | 14.45 | 10.15 | 3 | 145568 | 12948 | 79585869 |
Hyponatriuria | 14.45 | 10.15 | 4 | 145567 | 18 | 79598799 |
Sleep deficit | 14.40 | 10.15 | 14 | 145557 | 1162 | 79597655 |
Nasopharyngitis | 14.40 | 10.15 | 353 | 145218 | 253528 | 79345289 |
Eczema eyelids | 14.35 | 10.15 | 7 | 145564 | 184 | 79598633 |
Brain injury | 14.35 | 10.15 | 50 | 145521 | 11467 | 79587350 |
Tuberculosis | 14.18 | 10.15 | 5 | 145566 | 15193 | 79583624 |
Transplant rejection | 14.14 | 10.15 | 9 | 145562 | 19428 | 79579389 |
Panic attack | 14.14 | 10.15 | 84 | 145487 | 24132 | 79574685 |
Homeless | 14.08 | 10.15 | 6 | 145565 | 114 | 79598703 |
Affective disorder | 13.93 | 10.15 | 40 | 145531 | 8279 | 79590538 |
Acute myopia | 13.89 | 10.15 | 6 | 145565 | 118 | 79598699 |
Personality disorder | 13.82 | 10.15 | 33 | 145538 | 6113 | 79592704 |
Aspiration | 13.81 | 10.15 | 73 | 145498 | 20085 | 79578732 |
Pericardial effusion | 13.81 | 10.15 | 41 | 145530 | 46196 | 79552621 |
Nodule | 13.74 | 10.15 | 13 | 145558 | 22981 | 79575836 |
Food aversion | 13.67 | 10.15 | 13 | 145558 | 1050 | 79597767 |
Glucose tolerance impaired | 13.66 | 10.15 | 39 | 145532 | 8045 | 79590772 |
Hypotension | 13.66 | 10.15 | 956 | 144615 | 439361 | 79159456 |
Anticholinergic syndrome | 13.61 | 10.15 | 24 | 145547 | 3587 | 79595230 |
Pancreatitis acute | 13.40 | 10.15 | 46 | 145525 | 49558 | 79549259 |
Delusion | 13.34 | 10.15 | 73 | 145498 | 20350 | 79578467 |
Urinary retention | 13.28 | 10.15 | 160 | 145411 | 56470 | 79542347 |
Accommodation disorder | 13.24 | 10.15 | 10 | 145561 | 588 | 79598229 |
Neutropenic sepsis | 13.23 | 10.15 | 18 | 145553 | 27046 | 79571771 |
Colitis | 13.19 | 10.15 | 79 | 145492 | 73228 | 79525589 |
Somnambulism | 13.17 | 10.15 | 31 | 145540 | 5690 | 79593127 |
Genital infection female | 13.13 | 10.15 | 5 | 145566 | 70 | 79598747 |
Deformity | 13.11 | 10.15 | 43 | 145528 | 9562 | 79589255 |
Holmes-Adie pupil | 13.09 | 10.15 | 4 | 145567 | 27 | 79598790 |
Autoimmune disorder | 13.06 | 10.15 | 7 | 145564 | 16605 | 79582212 |
Blood prolactin increased | 13.02 | 10.15 | 25 | 145546 | 3986 | 79594831 |
Epstein-Barr virus infection | 13.01 | 10.15 | 5 | 145566 | 14411 | 79584406 |
Haematochezia | 13.01 | 10.15 | 100 | 145471 | 87545 | 79511272 |
Alcohol interaction | 13.00 | 10.15 | 28 | 145543 | 4846 | 79593971 |
Ventricular fibrillation | 12.99 | 10.15 | 24 | 145547 | 31902 | 79566915 |
Bladder cancer | 12.94 | 10.15 | 10 | 145561 | 19516 | 79579301 |
Hepatotoxicity | 12.89 | 10.15 | 147 | 145424 | 51205 | 79547612 |
Cholecystitis | 12.76 | 10.15 | 13 | 145558 | 22199 | 79576618 |
Myotonia | 12.76 | 10.15 | 7 | 145564 | 236 | 79598581 |
Delirium febrile | 12.75 | 10.15 | 5 | 145566 | 76 | 79598741 |
Tumour lysis syndrome | 12.66 | 10.15 | 15 | 145556 | 23924 | 79574893 |
Neoplasm progression | 12.60 | 10.15 | 50 | 145521 | 51632 | 79547185 |
Breast cancer | 12.56 | 10.15 | 105 | 145466 | 33676 | 79565141 |
Compulsive shopping | 12.48 | 10.15 | 11 | 145560 | 805 | 79598012 |
Pulmonary toxicity | 12.48 | 10.15 | 4 | 145567 | 12910 | 79585907 |
Thyroglobulin increased | 12.41 | 10.15 | 5 | 145566 | 82 | 79598735 |
Plasma cell mastitis | 12.39 | 10.15 | 4 | 145567 | 33 | 79598784 |
Obsessive rumination | 12.32 | 10.15 | 3 | 145568 | 7 | 79598810 |
Hanging | 12.32 | 10.15 | 6 | 145565 | 157 | 79598660 |
Hyperbilirubinaemia | 12.30 | 10.15 | 16 | 145555 | 24502 | 79574315 |
Persistent depressive disorder | 12.30 | 10.15 | 13 | 145558 | 1192 | 79597625 |
Balance disorder | 12.29 | 10.15 | 251 | 145320 | 98606 | 79500211 |
Creatinine renal clearance decreased | 12.25 | 10.15 | 10 | 145561 | 18992 | 79579825 |
Joint effusion | 12.22 | 10.15 | 9 | 145562 | 18005 | 79580812 |
Immobile | 12.14 | 10.15 | 34 | 145537 | 6939 | 79591878 |
Renal injury | 12.09 | 10.15 | 8 | 145563 | 16919 | 79581898 |
Pulmonary alveolar haemorrhage | 12.09 | 10.15 | 3 | 145568 | 11454 | 79587363 |
Gamma-glutamyltransferase increased | 12.04 | 10.15 | 55 | 145516 | 54625 | 79544192 |
Haemolytic anaemia | 11.97 | 10.15 | 9 | 145562 | 17811 | 79581006 |
Intervertebral disc protrusion | 11.96 | 10.15 | 79 | 145492 | 23542 | 79575275 |
Foaming at mouth | 11.95 | 10.15 | 16 | 145555 | 1881 | 79596936 |
Peritoneal perforation | 11.89 | 10.15 | 6 | 145565 | 170 | 79598647 |
Pneumonitis | 11.81 | 10.15 | 64 | 145507 | 60796 | 79538021 |
Blood cholinesterase decreased | 11.81 | 10.15 | 7 | 145564 | 274 | 79598543 |
Sedative therapy | 11.78 | 10.15 | 3 | 145568 | 9 | 79598808 |
Blood alkaline phosphatase increased | 11.78 | 10.15 | 68 | 145503 | 63596 | 79535221 |
Bruxism | 11.75 | 10.15 | 24 | 145547 | 4002 | 79594815 |
Tongue discolouration | 11.75 | 10.15 | 23 | 145548 | 3720 | 79595097 |
Lack of injection site rotation | 11.74 | 10.15 | 9 | 145562 | 541 | 79598276 |
Hypocalcaemia | 11.74 | 10.15 | 49 | 145522 | 49875 | 79548942 |
Heat stroke | 11.72 | 10.15 | 15 | 145556 | 1688 | 79597129 |
Sleep-related eating disorder | 11.68 | 10.15 | 10 | 145561 | 704 | 79598113 |
Distributive shock | 11.64 | 10.15 | 19 | 145552 | 2668 | 79596149 |
Knee deformity | 11.61 | 10.15 | 13 | 145558 | 1272 | 79597545 |
Generalised anxiety disorder | 11.56 | 10.15 | 17 | 145554 | 2180 | 79596637 |
Cerebral haemorrhage | 11.55 | 10.15 | 60 | 145511 | 57613 | 79541204 |
Peripheral swelling | 11.46 | 10.15 | 390 | 145181 | 269227 | 79329590 |
Lip dry | 11.41 | 10.15 | 7 | 145564 | 15411 | 79583406 |
Autoimmune nephritis | 11.38 | 10.15 | 10 | 145561 | 729 | 79598088 |
Troponin increased | 11.37 | 10.15 | 67 | 145504 | 19188 | 79579629 |
Second primary malignancy | 11.35 | 10.15 | 6 | 145565 | 14344 | 79584473 |
Wandering pacemaker | 11.32 | 10.15 | 3 | 145568 | 11 | 79598806 |
Hyperlipidaemia | 11.29 | 10.15 | 84 | 145487 | 26009 | 79572808 |
Device related infection | 11.29 | 10.15 | 29 | 145542 | 34265 | 79564552 |
Impaired gastric emptying | 11.25 | 10.15 | 43 | 145528 | 10310 | 79588507 |
Bronchial hyperreactivity | 11.19 | 10.15 | 20 | 145551 | 3020 | 79595797 |
Haemodialysis | 11.18 | 10.15 | 10 | 145561 | 18158 | 79580659 |
Personal relationship issue | 11.16 | 10.15 | 6 | 145565 | 194 | 79598623 |
Infusion site urticaria | 11.16 | 10.15 | 12 | 145559 | 1122 | 79597695 |
Drug screen negative | 11.13 | 10.15 | 7 | 145564 | 305 | 79598512 |
Dermatitis exfoliative | 11.11 | 10.15 | 3 | 145568 | 10826 | 79587991 |
Neurotoxicity | 11.09 | 10.15 | 27 | 145544 | 32491 | 79566326 |
Pregnancy | 11.09 | 10.15 | 20 | 145551 | 26831 | 79571986 |
Inappropriate schedule of product administration | 11.08 | 10.15 | 321 | 145250 | 133307 | 79465510 |
Toxicologic test abnormal | 11.01 | 10.15 | 13 | 145558 | 1347 | 79597470 |
Cardiac failure acute | 10.97 | 10.15 | 11 | 145560 | 18918 | 79579899 |
Screaming | 10.96 | 10.15 | 23 | 145548 | 3910 | 79594907 |
Feeling of despair | 10.96 | 10.15 | 19 | 145552 | 2802 | 79596015 |
Anaphylactic reaction | 10.87 | 10.15 | 99 | 145472 | 83644 | 79515173 |
Inflammation | 10.84 | 10.15 | 114 | 145457 | 93639 | 79505178 |
Antipsychotic drug level above therapeutic | 10.81 | 10.15 | 16 | 145555 | 2064 | 79596753 |
Rapid eye movement sleep behaviour disorder | 10.78 | 10.15 | 8 | 145563 | 458 | 79598359 |
Serum serotonin increased | 10.77 | 10.15 | 7 | 145564 | 323 | 79598494 |
White blood cell count increased | 10.68 | 10.15 | 86 | 145485 | 74547 | 79524270 |
Morbid thoughts | 10.68 | 10.15 | 10 | 145561 | 792 | 79598025 |
Osteomyelitis | 10.66 | 10.15 | 28 | 145543 | 32837 | 79565980 |
Skin sensitisation | 10.63 | 10.15 | 11 | 145560 | 984 | 79597833 |
Hangover | 10.63 | 10.15 | 16 | 145555 | 2096 | 79596721 |
Neuropsychiatric symptoms | 10.59 | 10.15 | 13 | 145558 | 1402 | 79597415 |
Hip fracture | 10.59 | 10.15 | 94 | 145477 | 30667 | 79568150 |
Pyelonephritis | 10.55 | 10.15 | 13 | 145558 | 20375 | 79578442 |
Bacterial vaginosis | 10.54 | 10.15 | 12 | 145559 | 1196 | 79597621 |
Nausea | 10.49 | 10.15 | 1941 | 143630 | 955255 | 78643562 |
Klebsiella infection | 10.48 | 10.15 | 8 | 145563 | 15712 | 79583105 |
Posterior reversible encephalopathy syndrome | 10.48 | 10.15 | 20 | 145551 | 26261 | 79572556 |
Emotional disorder | 10.48 | 10.15 | 53 | 145518 | 14334 | 79584483 |
Metastases to lymph nodes | 10.45 | 10.15 | 3 | 145568 | 10394 | 79588423 |
Crying | 10.44 | 10.15 | 75 | 145496 | 22968 | 79575849 |
Ileus | 10.40 | 10.15 | 20 | 145551 | 26191 | 79572626 |
Eosinophilia | 10.35 | 10.15 | 45 | 145526 | 45300 | 79553517 |
Oppositional defiant disorder | 10.32 | 10.15 | 8 | 145563 | 489 | 79598328 |
Enteritis | 10.27 | 10.15 | 7 | 145564 | 14576 | 79584241 |
Kidney transplant rejection | 10.21 | 10.15 | 3 | 145568 | 10243 | 79588574 |
Enterocolitis | 10.18 | 10.15 | 7 | 145564 | 14505 | 79584312 |
Anorgasmia | 10.17 | 10.15 | 12 | 145559 | 1242 | 79597575 |
Shock haemorrhagic | 10.16 | 10.15 | 13 | 145558 | 20047 | 79578770 |
None
Source | Code | Description |
---|---|---|
ATC | N06AX05 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Other antidepressants |
CHEBI has role | CHEBI:35469 | antidepressants |
CHEBI has role | CHEBI:35474 | anti-anxiety agents |
CHEBI has role | CHEBI:35717 | hypnotics |
CHEBI has role | CHEBI:37887 | adrenergic blockers |
CHEBI has role | CHEBI:37955 | H1 receptor antagonists |
CHEBI has role | CHEBI:50949 | SSRI |
MeSH PA | D014151 | Anti-Anxiety Agents |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D018687 | Antidepressive Agents, Second-Generation |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D017367 | Selective Serotonin Reuptake Inhibitors |
MeSH PA | D018490 | Serotonin Agents |
MeSH PA | D014149 | Tranquilizing Agents |
FDA EPC | N0000175696 | Serotonin Reuptake Inhibitor |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Major depressive disorder | indication | 370143000 | |
Insomnia | off-label use | 193462001 | |
Priapism | contraindication | 6273006 | DOID:9286 |
Suicidal thoughts | contraindication | 6471006 | |
Orthostatic hypotension | contraindication | 28651003 | |
Torsades de pointes | contraindication | 31722008 | |
Hypokalemia | contraindication | 43339004 | |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Heart disease | contraindication | 56265001 | DOID:114 |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Prolonged QT interval | contraindication | 111975006 | |
Hypomagnesemia | contraindication | 190855004 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Myocardial infarction in recovery phase | contraindication | 418044006 | |
Congenital long QT syndrome | contraindication | 442917000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 6.98 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
150MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | OLEPTRO | ANGELINI PHARMA | N022411 | Feb. 2, 2010 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 7829120 | March 27, 2027 | METHOD OF TREATING DEPRESSION |
300MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | OLEPTRO | ANGELINI PHARMA | N022411 | Feb. 2, 2010 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 7829120 | March 27, 2027 | METHOD OF TREATING DEPRESSION |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Kd | 6.80 | WOMBAT-PK | CHEMBL | |||
5-hydroxytryptamine receptor 2C | GPCR | ANTAGONIST | Ki | 6.65 | WOMBAT-PK | CHEMBL | |||
5-hydroxytryptamine receptor 2A | GPCR | ANTAGONIST | Ki | 7.35 | WOMBAT-PK | CHEMBL | |||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.03 | DRUG MATRIX | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.54 | WOMBAT-PK | |||||
Sodium-dependent noradrenaline transporter | Transporter | Kd | 5.07 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 7.02 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 7.08 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 7 | GPCR | Ki | 5.75 | PDSP | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 9.55 | WOMBAT-PK | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 6.75 | DRUG MATRIX | |||||
D(3) dopamine receptor | GPCR | Ki | 5.90 | DRUG MATRIX | |||||
Histamine H1 receptor | GPCR | Ki | 6.21 | WOMBAT-PK | |||||
Histamine H2 receptor | GPCR | Ki | 5.48 | PDSP | |||||
5-hydroxytryptamine receptor 1D | GPCR | Ki | 6.98 | PDSP | |||||
Alpha-2C adrenergic receptor | GPCR | Ki | 6.81 | PDSP | |||||
Sodium-dependent dopamine transporter | Transporter | Kd | 5.13 | WOMBAT-PK | |||||
D(4) dopamine receptor | GPCR | Ki | 6.15 | PDSP | |||||
Alpha-1D adrenergic receptor | GPCR | Ki | 7.33 | DRUG MATRIX | |||||
D(1A) dopamine receptor | GPCR | Ki | 5.43 | PDSP | |||||
HLA class I histocompatibility antigen, A-3 alpha chain | Unclassified | Kd | 5.60 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | Ki | 5.46 | PDSP | |||||
Alpha-2A adrenergic receptor | GPCR | Ki | 6.58 | WOMBAT-PK | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 7.22 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 1B | GPCR | Ki | 6.08 | DRUG MATRIX | |||||
Membrane-associated progesterone receptor component 1 | Membrane receptor | Ki | 6.08 | DRUG MATRIX | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 6.93 | CHEMBL | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 6.65 | CHEMBL | |||||
5-hydroxytryptamine receptor 2A | GPCR | IC50 | 7.77 | CHEMBL | |||||
5-hydroxytryptamine receptor 2C | GPCR | ANTAGONIST | Ki | 6.70 | IUPHAR |
ID | Source |
---|---|
4019954 | VUID |
N0000148039 | NUI |
D00820 | KEGG_DRUG |
25332-39-2 | SECONDARY_CAS_RN |
4018812 | VANDF |
4019954 | VANDF |
C0040805 | UMLSCUI |
CHEBI:9654 | CHEBI |
CHEMBL621 | ChEMBL_ID |
DB00656 | DRUGBANK_ID |
CHEMBL1200798 | ChEMBL_ID |
D014196 | MESH_DESCRIPTOR_UI |
5533 | PUBCHEM_CID |
213 | IUPHAR_LIGAND_ID |
2878 | INN_ID |
YBK48BXK30 | UNII |
10737 | RXNORM |
1504 | MMSL |
5609 | MMSL |
d00395 | MMSL |
001511 | NDDF |
004610 | NDDF |
372829000 | SNOMEDCT_US |
58956008 | SNOMEDCT_US |
7336002 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0711 | TABLET | 300 mg | ORAL | ANDA | 26 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0711 | TABLET | 300 mg | ORAL | ANDA | 26 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0733 | TABLET | 300 mg | ORAL | ANDA | 26 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-2578 | TABLET | 50 mg | ORAL | ANDA | 31 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-2579 | TABLET | 100 mg | ORAL | ANDA | 31 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8339 | TABLET | 150 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8339 | TABLET | 150 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8371 | TABLET | 50 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8371 | TABLET | 50 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8386 | TABLET | 100 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8386 | TABLET | 100 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6554 | TABLET | 50 mg | ORAL | ANDA | 21 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6555 | TABLET | 100 mg | ORAL | ANDA | 21 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6868 | TABLET | 50 mg | ORAL | ANDA | 27 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6868 | TABLET | 50 mg | ORAL | ANDA | 27 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6869 | TABLET | 100 mg | ORAL | ANDA | 27 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6869 | TABLET | 100 mg | ORAL | ANDA | 27 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7212 | TABLET | 150 mg | ORAL | ANDA | 27 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-532 | TABLET | 100 mg | ORAL | ANDA | 31 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-533 | TABLET | 150 mg | ORAL | ANDA | 24 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-534 | TABLET | 50 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-867 | TABLET | 150 mg | ORAL | ANDA | 21 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-193 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 31 sections |
Trazodone Hydrochloride | Human Prescription Drug Label | 1 | 13107-079 | TABLET | 50 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | Human Prescription Drug Label | 1 | 13107-079 | TABLET | 50 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | Human Prescription Drug Label | 1 | 13107-080 | TABLET | 100 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | Human Prescription Drug Label | 1 | 13107-080 | TABLET | 100 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | Human Prescription Drug Label | 1 | 13107-081 | TABLET | 150 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | Human Prescription Drug Label | 1 | 13107-081 | TABLET | 150 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | Human Prescription Drug Label | 1 | 13107-082 | TABLET | 300 mg | ORAL | ANDA | 30 sections |