trazodone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2717 | 19794-93-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.30 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.20 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 23.05 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 81 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.52 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 1.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.08 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 7.30 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 24, 1981 | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Completed suicide | 1266.84 | 9.74 | 1653 | 110663 | 144267 | 46429479 |
| Drug abuse | 517.36 | 9.74 | 698 | 111618 | 62710 | 46511036 |
| Toxicity to various agents | 421.60 | 9.74 | 1291 | 111025 | 210475 | 46363271 |
| Serotonin syndrome | 356.08 | 9.74 | 361 | 111955 | 23859 | 46549887 |
| Sopor | 314.47 | 9.74 | 308 | 112008 | 19520 | 46554226 |
| Respiratory arrest | 232.21 | 9.74 | 343 | 111973 | 33473 | 46540273 |
| Suicidal ideation | 194.11 | 9.74 | 423 | 111893 | 55959 | 46517787 |
| Cardio-respiratory arrest | 185.81 | 9.74 | 431 | 111885 | 59438 | 46514308 |
| Depression | 171.24 | 9.74 | 836 | 111480 | 169268 | 46404478 |
| Suicide attempt | 155.44 | 9.74 | 382 | 111934 | 54654 | 46519092 |
| Overdose | 154.63 | 9.74 | 568 | 111748 | 101411 | 46472335 |
| Poisoning | 124.69 | 9.74 | 161 | 112155 | 13833 | 46559913 |
| Rheumatoid arthritis | 118.06 | 9.74 | 251 | 112065 | 239964 | 46333782 |
| Insomnia | 115.42 | 9.74 | 735 | 111581 | 164189 | 46409557 |
| Cardiac arrest | 113.85 | 9.74 | 475 | 111841 | 89924 | 46483822 |
| Presbyacusis | 97.80 | 9.74 | 69 | 112247 | 2753 | 46570993 |
| Maternal exposure during pregnancy | 92.52 | 9.74 | 67 | 112249 | 102482 | 46471264 |
| Pleural thickening | 88.89 | 9.74 | 63 | 112253 | 2532 | 46571214 |
| Pleural fibrosis | 87.59 | 9.74 | 71 | 112245 | 3498 | 46570248 |
| Hypomania | 86.58 | 9.74 | 77 | 112239 | 4311 | 46569435 |
| Anxiety | 85.61 | 9.74 | 738 | 111578 | 181219 | 46392527 |
| Neutropenia | 84.18 | 9.74 | 134 | 112182 | 143070 | 46430676 |
| Agitation | 83.37 | 9.74 | 308 | 112008 | 55107 | 46518639 |
| Blood magnesium increased | 82.40 | 9.74 | 64 | 112252 | 2963 | 46570783 |
| Electrocardiogram QT prolonged | 81.21 | 9.74 | 290 | 112026 | 51035 | 46522711 |
| Drug withdrawal syndrome | 78.26 | 9.74 | 191 | 112125 | 27193 | 46546553 |
| Irritability | 77.57 | 9.74 | 197 | 112119 | 28749 | 46544997 |
| Tremor | 72.73 | 9.74 | 502 | 111814 | 115137 | 46458609 |
| Deafness neurosensory | 71.58 | 9.74 | 70 | 112246 | 4424 | 46569322 |
| Exposure during pregnancy | 67.69 | 9.74 | 97 | 112219 | 108115 | 46465631 |
| Anaemia | 65.38 | 9.74 | 355 | 111961 | 255424 | 46318322 |
| Thrombocytopenia | 64.86 | 9.74 | 129 | 112187 | 126452 | 46447294 |
| Withdrawal syndrome | 64.59 | 9.74 | 138 | 112178 | 17996 | 46555750 |
| Febrile neutropenia | 63.04 | 9.74 | 81 | 112235 | 94546 | 46479200 |
| Psychotic disorder | 59.62 | 9.74 | 153 | 112163 | 22468 | 46551278 |
| Schizophrenia | 58.91 | 9.74 | 87 | 112229 | 8481 | 46565265 |
| Epigastric discomfort | 58.00 | 9.74 | 70 | 112246 | 5614 | 46568132 |
| Myocardial stunning | 57.64 | 9.74 | 20 | 112296 | 155 | 46573591 |
| Hand deformity | 56.47 | 9.74 | 8 | 112308 | 34566 | 46539180 |
| Systemic lupus erythematosus | 55.69 | 9.74 | 45 | 112271 | 65135 | 46508611 |
| Malignant neoplasm progression | 55.25 | 9.74 | 45 | 112271 | 64881 | 46508865 |
| Synovitis | 54.94 | 9.74 | 40 | 112276 | 61035 | 46512711 |
| Tardive dyskinesia | 53.90 | 9.74 | 78 | 112238 | 7465 | 46566281 |
| Intentional overdose | 53.36 | 9.74 | 302 | 112014 | 64642 | 46509104 |
| Mucosal inflammation | 53.17 | 9.74 | 14 | 112302 | 38962 | 46534784 |
| Joint swelling | 52.08 | 9.74 | 214 | 112102 | 165859 | 46407887 |
| Sedation | 51.38 | 9.74 | 146 | 112170 | 22764 | 46550982 |
| Contraindicated product administered | 50.64 | 9.74 | 71 | 112245 | 79876 | 46493870 |
| General physical health deterioration | 50.33 | 9.74 | 129 | 112187 | 115640 | 46458106 |
| Infusion related reaction | 50.26 | 9.74 | 105 | 112211 | 101103 | 46472643 |
| Drug screen positive | 48.26 | 9.74 | 53 | 112263 | 3838 | 46569908 |
| Jaundice cholestatic | 48.18 | 9.74 | 60 | 112256 | 4969 | 46568777 |
| Drug intolerance | 47.04 | 9.74 | 188 | 112128 | 146861 | 46426885 |
| Drug interaction | 46.44 | 9.74 | 716 | 111600 | 202378 | 46371368 |
| Migraine | 46.39 | 9.74 | 308 | 112008 | 69718 | 46504028 |
| Pyrexia | 45.96 | 9.74 | 578 | 111738 | 348224 | 46225522 |
| Rash | 45.05 | 9.74 | 596 | 111720 | 355916 | 46217830 |
| Haemoglobin decreased | 45.05 | 9.74 | 159 | 112157 | 128790 | 46444956 |
| Depressed level of consciousness | 44.35 | 9.74 | 229 | 112087 | 47340 | 46526406 |
| Akathisia | 44.19 | 9.74 | 72 | 112244 | 7642 | 46566104 |
| Pancytopenia | 44.14 | 9.74 | 86 | 112230 | 84972 | 46488774 |
| Bone marrow failure | 43.76 | 9.74 | 9 | 112307 | 29660 | 46544086 |
| Hyperreflexia | 43.02 | 9.74 | 58 | 112258 | 5196 | 46568550 |
| Visual perseveration | 42.79 | 9.74 | 13 | 112303 | 62 | 46573684 |
| Nightmare | 42.44 | 9.74 | 111 | 112205 | 16487 | 46557259 |
| Acute kidney injury | 41.56 | 9.74 | 365 | 111951 | 235490 | 46338256 |
| Asphyxia | 40.90 | 9.74 | 57 | 112259 | 5269 | 46568477 |
| Cardiac failure | 40.48 | 9.74 | 82 | 112234 | 79866 | 46493880 |
| Bone cyst | 40.48 | 9.74 | 36 | 112280 | 2015 | 46571731 |
| Sleep disorder | 40.03 | 9.74 | 220 | 112096 | 46575 | 46527171 |
| Anger | 39.70 | 9.74 | 88 | 112228 | 11764 | 46561982 |
| Accidental poisoning | 39.20 | 9.74 | 22 | 112294 | 583 | 46573163 |
| Osteopenia | 38.92 | 9.74 | 109 | 112207 | 16852 | 46556894 |
| Swelling | 38.67 | 9.74 | 161 | 112155 | 124350 | 46449396 |
| Memory impairment | 38.05 | 9.74 | 317 | 111999 | 77020 | 46496726 |
| Multiple sclerosis relapse | 38.03 | 9.74 | 201 | 112115 | 41924 | 46531822 |
| Muscle rigidity | 38.03 | 9.74 | 78 | 112238 | 9883 | 46563863 |
| Suspected suicide | 37.47 | 9.74 | 51 | 112265 | 4610 | 46569136 |
| Treatment failure | 37.24 | 9.74 | 108 | 112208 | 92979 | 46480767 |
| Adjustment disorder with mixed anxiety and depressed mood | 36.93 | 9.74 | 12 | 112304 | 74 | 46573672 |
| Intentional self-injury | 36.90 | 9.74 | 135 | 112181 | 24031 | 46549715 |
| Abnormal behaviour | 36.79 | 9.74 | 123 | 112193 | 20935 | 46552811 |
| Leukopenia | 35.55 | 9.74 | 69 | 112247 | 68274 | 46505472 |
| Cyst | 35.21 | 9.74 | 85 | 112231 | 12015 | 46561731 |
| Torsade de pointes | 34.96 | 9.74 | 85 | 112231 | 12069 | 46561677 |
| Mental disorder | 34.85 | 9.74 | 126 | 112190 | 22299 | 46551447 |
| Pleurothotonus | 34.72 | 9.74 | 26 | 112290 | 1139 | 46572607 |
| Somatic delusion | 33.62 | 9.74 | 20 | 112296 | 593 | 46573153 |
| Sepsis | 33.48 | 9.74 | 191 | 112125 | 135823 | 46437923 |
| Platelet count decreased | 33.17 | 9.74 | 126 | 112190 | 99898 | 46473848 |
| Polycystic ovaries | 32.84 | 9.74 | 27 | 112289 | 1357 | 46572389 |
| Oral discomfort | 32.62 | 9.74 | 64 | 112252 | 7854 | 46565892 |
| Toxic epidermal necrolysis | 32.36 | 9.74 | 7 | 112309 | 22271 | 46551475 |
| Injection site mass | 31.94 | 9.74 | 94 | 112222 | 14946 | 46558800 |
| Affective disorder | 31.83 | 9.74 | 48 | 112268 | 4767 | 46568979 |
| Intentional product misuse | 31.63 | 9.74 | 208 | 112108 | 46920 | 46526826 |
| Priapism | 31.47 | 9.74 | 7 | 112309 | 5 | 46573741 |
| Arteriosclerosis coronary artery | 31.30 | 9.74 | 64 | 112252 | 8092 | 46565654 |
| Cholestasis | 30.85 | 9.74 | 13 | 112303 | 26880 | 46546866 |
| Osteosclerosis | 30.61 | 9.74 | 40 | 112276 | 3476 | 46570270 |
| Blood prolactin increased | 30.43 | 9.74 | 37 | 112279 | 2990 | 46570756 |
| Dyskinesia | 30.33 | 9.74 | 144 | 112172 | 28781 | 46544965 |
| Pericarditis | 30.07 | 9.74 | 10 | 112306 | 23917 | 46549829 |
| Confusional state | 30.02 | 9.74 | 546 | 111770 | 159346 | 46414400 |
| C-reactive protein increased | 29.74 | 9.74 | 60 | 112256 | 58530 | 46515216 |
| Confabulation | 29.64 | 9.74 | 14 | 112302 | 256 | 46573490 |
| Hereditary angioedema | 29.60 | 9.74 | 50 | 112266 | 5466 | 46568280 |
| Blood potassium increased | 29.55 | 9.74 | 99 | 112217 | 16868 | 46556878 |
| Dissociation | 29.45 | 9.74 | 29 | 112287 | 1848 | 46571898 |
| Unresponsive to stimuli | 29.37 | 9.74 | 154 | 112162 | 32020 | 46541726 |
| Bradyphrenia | 28.94 | 9.74 | 53 | 112263 | 6177 | 46567569 |
| Mental status changes | 28.61 | 9.74 | 173 | 112143 | 37915 | 46535831 |
| Psychomotor hyperactivity | 28.48 | 9.74 | 68 | 112248 | 9545 | 46564201 |
| Hepatocellular injury | 28.33 | 9.74 | 18 | 112298 | 29504 | 46544242 |
| Mood altered | 28.30 | 9.74 | 82 | 112234 | 12925 | 46560821 |
| Substance abuse | 28.20 | 9.74 | 42 | 112274 | 4125 | 46569621 |
| Cytomegalovirus infection | 27.82 | 9.74 | 5 | 112311 | 18139 | 46555607 |
| Weight increased | 27.24 | 9.74 | 551 | 111765 | 163922 | 46409824 |
| Wound | 27.11 | 9.74 | 38 | 112278 | 42764 | 46530982 |
| Abnormal dreams | 26.54 | 9.74 | 69 | 112247 | 10210 | 46563536 |
| Accidental death | 26.31 | 9.74 | 27 | 112289 | 1808 | 46571938 |
| Pneumocystis jirovecii pneumonia | 26.18 | 9.74 | 3 | 112313 | 15245 | 46558501 |
| Tachyphrenia | 26.11 | 9.74 | 23 | 112293 | 1271 | 46572475 |
| Disease progression | 25.95 | 9.74 | 122 | 112194 | 91178 | 46482568 |
| Balance disorder | 25.86 | 9.74 | 253 | 112063 | 64268 | 46509478 |
| Premature baby | 25.68 | 9.74 | 6 | 112310 | 18106 | 46555640 |
| Hyperkalaemia | 25.67 | 9.74 | 52 | 112264 | 50657 | 46523089 |
| Tearfulness | 25.61 | 9.74 | 40 | 112276 | 4095 | 46569651 |
| Pleural effusion | 25.29 | 9.74 | 108 | 112208 | 82844 | 46490902 |
| Skin lesion | 25.17 | 9.74 | 129 | 112187 | 26584 | 46547162 |
| Peripheral swelling | 25.08 | 9.74 | 251 | 112065 | 157820 | 46415926 |
| Bipolar disorder | 24.85 | 9.74 | 54 | 112262 | 7123 | 46566623 |
| Device expulsion | 24.81 | 9.74 | 18 | 112298 | 27524 | 46546222 |
| Premature delivery | 24.79 | 9.74 | 11 | 112305 | 22058 | 46551688 |
| Exostosis | 24.58 | 9.74 | 67 | 112249 | 10196 | 46563550 |
| Multiple organ dysfunction syndrome | 24.53 | 9.74 | 55 | 112261 | 51655 | 46522091 |
| Neuroleptic malignant syndrome | 24.08 | 9.74 | 70 | 112246 | 11052 | 46562694 |
| Septic shock | 24.01 | 9.74 | 66 | 112250 | 57827 | 46515919 |
| Plasma cell myeloma | 23.92 | 9.74 | 44 | 112272 | 44434 | 46529312 |
| Major depression | 23.92 | 9.74 | 51 | 112265 | 6639 | 46567107 |
| Aggression | 23.68 | 9.74 | 113 | 112203 | 22631 | 46551115 |
| Fibromyalgia | 23.31 | 9.74 | 159 | 112157 | 36304 | 46537442 |
| Drug reaction with eosinophilia and systemic symptoms | 23.29 | 9.74 | 22 | 112294 | 29526 | 46544220 |
| Rheumatoid factor positive | 23.29 | 9.74 | 10 | 112306 | 20451 | 46553295 |
| Somnolence | 23.20 | 9.74 | 516 | 111800 | 156005 | 46417741 |
| Hostility | 23.17 | 9.74 | 22 | 112294 | 1340 | 46572406 |
| Cardiac failure congestive | 23.02 | 9.74 | 128 | 112188 | 91622 | 46482124 |
| Depressed mood | 22.93 | 9.74 | 148 | 112168 | 33171 | 46540575 |
| Depressive symptom | 22.75 | 9.74 | 31 | 112285 | 2805 | 46570941 |
| Product dose omission issue | 22.65 | 9.74 | 548 | 111768 | 167972 | 46405774 |
| Stevens-Johnson syndrome | 22.64 | 9.74 | 14 | 112302 | 23283 | 46550463 |
| Hallucination, auditory | 22.63 | 9.74 | 67 | 112249 | 10689 | 46563057 |
| Alopecia | 22.52 | 9.74 | 266 | 112050 | 162148 | 46411598 |
| Hepatic function abnormal | 22.36 | 9.74 | 30 | 112286 | 34391 | 46539355 |
| Drug dependence | 22.28 | 9.74 | 101 | 112215 | 19800 | 46553946 |
| Exposure via ingestion | 22.12 | 9.74 | 34 | 112282 | 3433 | 46570313 |
| Alcoholism | 22.12 | 9.74 | 27 | 112289 | 2191 | 46571555 |
| Wound infection fungal | 21.72 | 9.74 | 8 | 112308 | 75 | 46573671 |
| Sensation of foreign body | 21.72 | 9.74 | 36 | 112280 | 3875 | 46569871 |
| Dry eye | 21.68 | 9.74 | 136 | 112180 | 30186 | 46543560 |
| Muscle twitching | 21.59 | 9.74 | 81 | 112235 | 14591 | 46559155 |
| Solar urticaria | 21.57 | 9.74 | 7 | 112309 | 43 | 46573703 |
| Abdominal discomfort | 21.57 | 9.74 | 246 | 112070 | 150919 | 46422827 |
| Galactorrhoea | 21.15 | 9.74 | 35 | 112281 | 3762 | 46569984 |
| Apallic syndrome | 21.05 | 9.74 | 15 | 112301 | 608 | 46573138 |
| Perseveration | 21.05 | 9.74 | 11 | 112305 | 252 | 46573494 |
| Off label use | 20.71 | 9.74 | 727 | 111589 | 379114 | 46194632 |
| Interstitial lung disease | 20.56 | 9.74 | 64 | 112252 | 53885 | 46519861 |
| Meningitis streptococcal | 20.43 | 9.74 | 9 | 112307 | 139 | 46573607 |
| Glossodynia | 20.40 | 9.74 | 48 | 112268 | 44325 | 46529421 |
| Abortion spontaneous | 20.24 | 9.74 | 47 | 112269 | 43599 | 46530147 |
| Hyper IgE syndrome | 19.79 | 9.74 | 10 | 112306 | 213 | 46573533 |
| Myoclonus | 19.29 | 9.74 | 77 | 112239 | 14275 | 46559471 |
| Vasoplegia syndrome | 19.27 | 9.74 | 18 | 112298 | 1074 | 46572672 |
| Poor quality sleep | 19.05 | 9.74 | 80 | 112236 | 15173 | 46558573 |
| Lung disorder | 19.00 | 9.74 | 48 | 112268 | 43256 | 46530490 |
| Atrial fibrillation | 18.79 | 9.74 | 159 | 112157 | 103431 | 46470315 |
| Plasma cell mastitis | 18.79 | 9.74 | 5 | 112311 | 13 | 46573733 |
| Fall | 18.45 | 9.74 | 968 | 111348 | 328129 | 46245617 |
| Periorbital swelling | 18.43 | 9.74 | 19 | 112297 | 1279 | 46572467 |
| Post-traumatic stress disorder | 18.25 | 9.74 | 34 | 112282 | 4014 | 46569732 |
| Oppositional defiant disorder | 18.07 | 9.74 | 6 | 112310 | 40 | 46573706 |
| Sleep apnoea syndrome | 18.06 | 9.74 | 103 | 112213 | 22098 | 46551648 |
| Lower respiratory tract infection | 17.87 | 9.74 | 70 | 112246 | 55019 | 46518727 |
| Compartment syndrome | 17.81 | 9.74 | 23 | 112293 | 1976 | 46571770 |
| Neutrophil count decreased | 17.64 | 9.74 | 50 | 112266 | 43376 | 46530370 |
| Body tinea | 17.64 | 9.74 | 16 | 112300 | 919 | 46572827 |
| Dysphoria | 17.59 | 9.74 | 36 | 112280 | 4553 | 46569193 |
| Marchiafava-Bignami disease | 17.58 | 9.74 | 5 | 112311 | 18 | 46573728 |
| Purple glove syndrome | 17.55 | 9.74 | 9 | 112307 | 198 | 46573548 |
| Nervousness | 17.51 | 9.74 | 123 | 112193 | 28352 | 46545394 |
| Restless legs syndrome | 17.44 | 9.74 | 80 | 112236 | 15763 | 46557983 |
| Metastases to liver | 17.38 | 9.74 | 13 | 112303 | 19572 | 46554174 |
| Sense of a foreshortened future | 17.37 | 9.74 | 4 | 112312 | 4 | 46573742 |
| Screaming | 17.22 | 9.74 | 29 | 112287 | 3162 | 46570584 |
| Alcohol withdrawal syndrome | 17.14 | 9.74 | 15 | 112301 | 822 | 46572924 |
| Sinus bradycardia | 16.99 | 9.74 | 72 | 112244 | 13710 | 46560036 |
| Red blood cell sedimentation rate increased | 16.95 | 9.74 | 18 | 112298 | 22871 | 46550875 |
| Homicidal ideation | 16.47 | 9.74 | 21 | 112295 | 1781 | 46571965 |
| Extrapyramidal disorder | 16.41 | 9.74 | 62 | 112254 | 11206 | 46562540 |
| Product use issue | 16.40 | 9.74 | 147 | 112169 | 94497 | 46479249 |
| Mood swings | 16.38 | 9.74 | 80 | 112236 | 16172 | 46557574 |
| Tonic clonic movements | 16.36 | 9.74 | 17 | 112299 | 1155 | 46572591 |
| Drug resistance | 16.11 | 9.74 | 11 | 112305 | 17357 | 46556389 |
| Mania | 16.06 | 9.74 | 60 | 112256 | 10786 | 46562960 |
| Heart rate abnormal | 15.97 | 9.74 | 29 | 112287 | 3358 | 46570388 |
| Cognitive disorder | 15.95 | 9.74 | 147 | 112169 | 36736 | 46537010 |
| Eczema eyelids | 15.95 | 9.74 | 7 | 112309 | 107 | 46573639 |
| Toxic skin eruption | 15.88 | 9.74 | 5 | 112311 | 12382 | 46561364 |
| Skin ulcer | 15.83 | 9.74 | 34 | 112282 | 32424 | 46541322 |
| Ascites | 15.70 | 9.74 | 41 | 112275 | 36543 | 46537203 |
| Neoplasm progression | 15.63 | 9.74 | 25 | 112291 | 26658 | 46547088 |
| Restlessness | 15.54 | 9.74 | 110 | 112206 | 25414 | 46548332 |
| Panic reaction | 15.42 | 9.74 | 30 | 112286 | 3659 | 46570087 |
| Face oedema | 15.41 | 9.74 | 14 | 112302 | 19139 | 46554607 |
| Renal failure | 15.37 | 9.74 | 187 | 112129 | 113407 | 46460339 |
| Sensitisation | 15.30 | 9.74 | 13 | 112303 | 684 | 46573062 |
| Crying | 15.22 | 9.74 | 95 | 112221 | 21046 | 46552700 |
| Coma | 14.98 | 9.74 | 210 | 112106 | 58139 | 46515607 |
| Anaphylactic shock | 14.95 | 9.74 | 16 | 112300 | 20258 | 46553488 |
| Feeling of despair | 14.89 | 9.74 | 20 | 112296 | 1785 | 46571961 |
| Angioedema | 14.76 | 9.74 | 47 | 112269 | 39295 | 46534451 |
| Haemangioma congenital | 14.75 | 9.74 | 11 | 112305 | 479 | 46573267 |
| Psychomotor skills impaired | 14.74 | 9.74 | 22 | 112294 | 2164 | 46571582 |
| Disorganised speech | 14.69 | 9.74 | 14 | 112302 | 857 | 46572889 |
| Rash maculo-papular | 14.61 | 9.74 | 28 | 112288 | 27846 | 46545900 |
| Mitral valve thickening | 14.61 | 9.74 | 5 | 112311 | 37 | 46573709 |
| Panic attack | 14.60 | 9.74 | 91 | 112225 | 20151 | 46553595 |
| Speech disorder | 14.58 | 9.74 | 142 | 112174 | 36025 | 46537721 |
| Obsessive-compulsive disorder | 14.49 | 9.74 | 27 | 112289 | 3188 | 46570558 |
| Arthropathy | 14.48 | 9.74 | 132 | 112184 | 84568 | 46489178 |
| Middle insomnia | 14.39 | 9.74 | 53 | 112263 | 9462 | 46564284 |
| Herpes zoster | 14.27 | 9.74 | 100 | 112216 | 67772 | 46505974 |
| Disturbance in attention | 14.27 | 9.74 | 127 | 112189 | 31433 | 46542313 |
| Injection site necrosis | 14.27 | 9.74 | 17 | 112299 | 1345 | 46572401 |
| Burning mouth syndrome | 14.19 | 9.74 | 10 | 112306 | 398 | 46573348 |
| Type 2 diabetes mellitus | 14.12 | 9.74 | 89 | 112227 | 19786 | 46553960 |
| Disseminated intravascular coagulation | 14.01 | 9.74 | 15 | 112301 | 18990 | 46554756 |
| Lethargy | 13.89 | 9.74 | 186 | 112130 | 50985 | 46522761 |
| Liver function test abnormal | 13.87 | 9.74 | 61 | 112255 | 46426 | 46527320 |
| Oedema peripheral | 13.83 | 9.74 | 286 | 112030 | 159420 | 46414326 |
| Chromaturia | 13.78 | 9.74 | 72 | 112244 | 14947 | 46558799 |
| Morbid thoughts | 13.76 | 9.74 | 11 | 112305 | 531 | 46573215 |
| Polyglandular autoimmune syndrome type II | 13.76 | 9.74 | 5 | 112311 | 45 | 46573701 |
| Initial insomnia | 13.74 | 9.74 | 32 | 112284 | 4420 | 46569326 |
| Spleen congestion | 13.73 | 9.74 | 7 | 112309 | 152 | 46573594 |
| Decreased interest | 13.62 | 9.74 | 26 | 112290 | 3126 | 46570620 |
| Therapeutic product effect decreased | 13.57 | 9.74 | 130 | 112186 | 82471 | 46491275 |
| Myoglobin blood increased | 13.55 | 9.74 | 17 | 112299 | 1419 | 46572327 |
| Skin texture abnormal | 13.52 | 9.74 | 9 | 112307 | 326 | 46573420 |
| Aspiration | 13.51 | 9.74 | 52 | 112264 | 9479 | 46564267 |
| Urticaria | 13.44 | 9.74 | 201 | 112115 | 117691 | 46456055 |
| Gambling disorder | 13.29 | 9.74 | 16 | 112300 | 1280 | 46572466 |
| Affect lability | 13.26 | 9.74 | 46 | 112270 | 7974 | 46565772 |
| Tongue discolouration | 13.26 | 9.74 | 25 | 112291 | 2979 | 46570767 |
| Granulocytopenia | 13.21 | 9.74 | 35 | 112281 | 5238 | 46568508 |
| Coagulopathy | 13.20 | 9.74 | 15 | 112301 | 18484 | 46555262 |
| Intervertebral disc degeneration | 13.19 | 9.74 | 65 | 112251 | 13187 | 46560559 |
| Gastrointestinal haemorrhage | 13.04 | 9.74 | 121 | 112195 | 77252 | 46496494 |
| Social avoidant behaviour | 12.99 | 9.74 | 24 | 112292 | 2815 | 46570931 |
| Ejection fraction | 12.91 | 9.74 | 11 | 112305 | 581 | 46573165 |
| Mydriasis | 12.91 | 9.74 | 55 | 112261 | 10498 | 46563248 |
| Rash erythematous | 12.91 | 9.74 | 41 | 112275 | 34309 | 46539437 |
| Feeling abnormal | 12.89 | 9.74 | 393 | 111923 | 124667 | 46449079 |
| Paranoia | 12.79 | 9.74 | 55 | 112261 | 10542 | 46563204 |
| Drug screen false positive | 12.75 | 9.74 | 13 | 112303 | 864 | 46572882 |
| Cerebral infarction | 12.66 | 9.74 | 23 | 112293 | 23343 | 46550403 |
| Slow speech | 12.63 | 9.74 | 16 | 112300 | 1348 | 46572398 |
| Encephalopathy | 12.63 | 9.74 | 130 | 112186 | 33459 | 46540287 |
| Self-injurious ideation | 12.54 | 9.74 | 21 | 112295 | 2279 | 46571467 |
| Borderline personality disorder | 12.43 | 9.74 | 12 | 112304 | 746 | 46573000 |
| Drug screen negative | 12.43 | 9.74 | 9 | 112307 | 374 | 46573372 |
| Drug ineffective | 12.42 | 9.74 | 1435 | 110881 | 676403 | 45897343 |
| Tracheitis | 12.38 | 9.74 | 12 | 112304 | 750 | 46572996 |
| Deformity | 12.33 | 9.74 | 42 | 112274 | 7215 | 46566531 |
| Stomatitis | 12.31 | 9.74 | 105 | 112211 | 68192 | 46505554 |
| Liver disorder | 12.29 | 9.74 | 47 | 112269 | 37199 | 46536547 |
| Osteonecrosis of jaw | 12.28 | 9.74 | 42 | 112274 | 34360 | 46539386 |
| Medication error | 12.28 | 9.74 | 121 | 112195 | 30790 | 46542956 |
| Personal relationship issue | 12.27 | 9.74 | 4 | 112312 | 25 | 46573721 |
| Hyperhidrosis | 12.16 | 9.74 | 291 | 112025 | 89017 | 46484729 |
| Palmar-plantar erythrodysaesthesia syndrome | 12.13 | 9.74 | 19 | 112297 | 20432 | 46553314 |
| Transplant rejection | 12.08 | 9.74 | 4 | 112312 | 9592 | 46564154 |
| Gastroenteritis radiation | 12.07 | 9.74 | 10 | 112306 | 508 | 46573238 |
| Peritoneal perforation | 12.04 | 9.74 | 6 | 112310 | 124 | 46573622 |
| Therapeutic product effect incomplete | 12.01 | 9.74 | 125 | 112191 | 78028 | 46495718 |
| Femur fracture | 12.00 | 9.74 | 47 | 112269 | 36950 | 46536796 |
| Inhibitory drug interaction | 11.94 | 9.74 | 19 | 112297 | 1976 | 46571770 |
| Anticholinergic syndrome | 11.93 | 9.74 | 18 | 112298 | 1788 | 46571958 |
| Thinking abnormal | 11.89 | 9.74 | 51 | 112265 | 9763 | 46563983 |
| Jaundice | 11.87 | 9.74 | 33 | 112283 | 28812 | 46544934 |
| Gamma-glutamyltransferase increased | 11.85 | 9.74 | 38 | 112278 | 31702 | 46542044 |
| Live birth | 11.84 | 9.74 | 5 | 112311 | 10325 | 46563421 |
| Nephrectomy | 11.79 | 9.74 | 10 | 112306 | 525 | 46573221 |
| Skin sensitisation | 11.73 | 9.74 | 12 | 112304 | 801 | 46572945 |
| Dyspnoea | 11.66 | 9.74 | 1075 | 111241 | 514473 | 46059273 |
| Holmes-Adie pupil | 11.53 | 9.74 | 4 | 112312 | 31 | 46573715 |
| Cholelithiasis | 11.51 | 9.74 | 143 | 112173 | 38538 | 46535208 |
| Urinary incontinence | 11.49 | 9.74 | 112 | 112204 | 28418 | 46545328 |
| False positive investigation result | 11.46 | 9.74 | 10 | 112306 | 546 | 46573200 |
| Pyelonephritis | 11.45 | 9.74 | 12 | 112304 | 15345 | 46558401 |
| Pericardial effusion | 11.45 | 9.74 | 28 | 112288 | 25515 | 46548231 |
| Erythema | 11.42 | 9.74 | 259 | 112057 | 142561 | 46431185 |
| Alanine aminotransferase decreased | 11.39 | 9.74 | 10 | 112306 | 550 | 46573196 |
| Aspartate aminotransferase decreased | 11.38 | 9.74 | 10 | 112306 | 551 | 46573195 |
| Cerebral haemorrhage | 11.28 | 9.74 | 33 | 112283 | 28338 | 46545408 |
| Caesarean section | 11.27 | 9.74 | 14 | 112302 | 16589 | 46557157 |
| Basal cell carcinoma | 11.25 | 9.74 | 20 | 112296 | 20467 | 46553279 |
| Delusion | 11.22 | 9.74 | 55 | 112261 | 11133 | 46562613 |
| Wandering pacemaker | 11.22 | 9.74 | 3 | 112313 | 8 | 46573738 |
| Disorientation | 11.20 | 9.74 | 137 | 112179 | 36781 | 46536965 |
| Pregnancy | 11.20 | 9.74 | 31 | 112285 | 27106 | 46546640 |
| Clonus | 11.17 | 9.74 | 28 | 112288 | 4052 | 46569694 |
| Small for dates baby | 11.07 | 9.74 | 26 | 112290 | 3611 | 46570135 |
| Road traffic accident | 11.06 | 9.74 | 96 | 112220 | 23595 | 46550151 |
| Acute myeloid leukaemia | 11.03 | 9.74 | 13 | 112303 | 15765 | 46557981 |
| Generalised oedema | 11.03 | 9.74 | 11 | 112305 | 14388 | 46559358 |
| Product packaging difficult to open | 11.01 | 9.74 | 4 | 112312 | 36 | 46573710 |
| Dysphagia | 10.86 | 9.74 | 253 | 112063 | 77059 | 46496687 |
| Body temperature decreased | 10.77 | 9.74 | 62 | 112254 | 13347 | 46560399 |
| Peritonitis | 10.69 | 9.74 | 21 | 112295 | 20693 | 46553053 |
| Drug eruption | 10.69 | 9.74 | 22 | 112294 | 21307 | 46552439 |
| Electrocardiogram T wave inversion | 10.55 | 9.74 | 25 | 112291 | 3491 | 46570255 |
| Product substitution issue | 10.49 | 9.74 | 67 | 112249 | 14964 | 46558782 |
| Autonomic nervous system imbalance | 10.47 | 9.74 | 20 | 112296 | 2406 | 46571340 |
| Economic problem | 10.43 | 9.74 | 18 | 112298 | 2002 | 46571744 |
| Tobacco user | 10.40 | 9.74 | 11 | 112305 | 763 | 46572983 |
| Foetal death | 10.40 | 9.74 | 4 | 112312 | 8739 | 46565007 |
| Incoherent | 10.35 | 9.74 | 29 | 112287 | 4483 | 46569263 |
| Dystonia | 10.35 | 9.74 | 54 | 112262 | 11203 | 46562543 |
| Anaphylactic reaction | 10.33 | 9.74 | 80 | 112236 | 53032 | 46520714 |
| Anoxia | 10.32 | 9.74 | 7 | 112309 | 262 | 46573484 |
| Accidental overdose | 10.26 | 9.74 | 83 | 112233 | 19983 | 46553763 |
| Epistaxis | 10.23 | 9.74 | 102 | 112214 | 64203 | 46509543 |
| Thyroglobulin increased | 10.22 | 9.74 | 4 | 112312 | 45 | 46573701 |
| Tuberculosis | 10.21 | 9.74 | 6 | 112310 | 10259 | 46563487 |
| Thrombosis | 10.19 | 9.74 | 86 | 112230 | 55983 | 46517763 |
| Helicobacter infection | 10.15 | 9.74 | 8 | 112308 | 11728 | 46562018 |
| Flat affect | 10.13 | 9.74 | 14 | 112302 | 1284 | 46572462 |
| Heterophoria | 10.11 | 9.74 | 3 | 112313 | 13 | 46573733 |
| Dyskinesia oesophageal | 10.11 | 9.74 | 3 | 112313 | 13 | 46573733 |
| Apraxia | 10.09 | 9.74 | 16 | 112300 | 1659 | 46572087 |
| Increased appetite | 10.09 | 9.74 | 44 | 112272 | 8483 | 46565263 |
| Impulsive behaviour | 9.87 | 9.74 | 15 | 112301 | 1500 | 46572246 |
| Apathy | 9.77 | 9.74 | 39 | 112277 | 7229 | 46566517 |
| Gastric ulcer | 9.77 | 9.74 | 24 | 112292 | 21839 | 46551907 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Priapism | 646.49 | 10.63 | 263 | 53892 | 4480 | 29893843 |
| Completed suicide | 606.10 | 10.63 | 819 | 53336 | 98673 | 29799650 |
| Serotonin syndrome | 488.33 | 10.63 | 338 | 53817 | 17553 | 29880770 |
| Drug abuse | 317.80 | 10.63 | 548 | 53607 | 81524 | 29816799 |
| Toxicity to various agents | 314.32 | 10.63 | 862 | 53293 | 176321 | 29722002 |
| Sopor | 163.19 | 10.63 | 145 | 54010 | 10846 | 29887477 |
| Insomnia | 136.91 | 10.63 | 425 | 53730 | 92911 | 29805412 |
| Suicidal ideation | 136.69 | 10.63 | 239 | 53916 | 35875 | 29862448 |
| Overdose | 128.31 | 10.63 | 389 | 53766 | 83948 | 29814375 |
| Depression | 124.57 | 10.63 | 403 | 53752 | 90034 | 29808289 |
| Anxiety | 116.19 | 10.63 | 392 | 53763 | 89479 | 29808844 |
| Respiratory arrest | 111.18 | 10.63 | 194 | 53961 | 29064 | 29869259 |
| Intentional overdose | 102.96 | 10.63 | 230 | 53925 | 41251 | 29857072 |
| Agitation | 97.27 | 10.63 | 265 | 53890 | 53808 | 29844515 |
| Suicide attempt | 96.20 | 10.63 | 208 | 53947 | 36489 | 29861834 |
| Electrocardiogram QT prolonged | 80.43 | 10.63 | 191 | 53964 | 35644 | 29862679 |
| Febrile neutropenia | 75.59 | 10.63 | 50 | 54105 | 106643 | 29791680 |
| Cardio-respiratory arrest | 74.90 | 10.63 | 251 | 53904 | 57055 | 29841268 |
| Mental status changes | 65.93 | 10.63 | 181 | 53974 | 36898 | 29861425 |
| Ventricular tachyarrhythmia | 63.66 | 10.63 | 23 | 54132 | 278 | 29898045 |
| Thrombocytopenia | 58.16 | 10.63 | 99 | 54056 | 136945 | 29761378 |
| Anaemia | 58.05 | 10.63 | 188 | 53967 | 207804 | 29690519 |
| Drug withdrawal syndrome | 57.38 | 10.63 | 117 | 54038 | 19692 | 29878631 |
| Drug interaction | 54.66 | 10.63 | 576 | 53579 | 198992 | 29699331 |
| Tremor | 53.14 | 10.63 | 273 | 53882 | 75090 | 29823233 |
| Aggression | 53.02 | 10.63 | 167 | 53988 | 36740 | 29861583 |
| Tardive dyskinesia | 51.06 | 10.63 | 54 | 54101 | 5003 | 29893320 |
| Poisoning | 50.60 | 10.63 | 81 | 54074 | 11301 | 29887022 |
| Intentional product misuse | 49.01 | 10.63 | 156 | 53999 | 34511 | 29863812 |
| Confusional state | 48.77 | 10.63 | 413 | 53742 | 134421 | 29763902 |
| Renal impairment | 45.54 | 10.63 | 51 | 54104 | 84133 | 29814190 |
| Pyrexia | 45.44 | 10.63 | 329 | 53826 | 294160 | 29604163 |
| Interstitial lung disease | 44.26 | 10.63 | 27 | 54128 | 60170 | 29838153 |
| Somnolence | 43.62 | 10.63 | 312 | 53843 | 96451 | 29801872 |
| Intentional self-injury | 41.67 | 10.63 | 82 | 54073 | 13450 | 29884873 |
| Antidepressant drug level above therapeutic | 40.10 | 10.63 | 14 | 54141 | 152 | 29898171 |
| General physical health deterioration | 39.85 | 10.63 | 75 | 54080 | 99869 | 29798454 |
| Neutropenia | 39.52 | 10.63 | 111 | 54044 | 128429 | 29769894 |
| Anger | 38.71 | 10.63 | 71 | 54084 | 11049 | 29887274 |
| Hepatic function abnormal | 38.22 | 10.63 | 14 | 54141 | 41931 | 29856392 |
| Symptom masked | 38.07 | 10.63 | 18 | 54137 | 445 | 29897878 |
| Paranoia | 37.96 | 10.63 | 67 | 54088 | 10121 | 29888202 |
| Alcoholism | 37.25 | 10.63 | 38 | 54117 | 3376 | 29894947 |
| Renal failure | 37.02 | 10.63 | 115 | 54040 | 128851 | 29769472 |
| Cardiac arrest | 36.00 | 10.63 | 289 | 53866 | 92561 | 29805762 |
| Restlessness | 35.95 | 10.63 | 106 | 54049 | 22493 | 29875830 |
| Pancytopenia | 35.54 | 10.63 | 62 | 54093 | 84990 | 29813333 |
| Septic shock | 34.98 | 10.63 | 38 | 54117 | 63569 | 29834754 |
| Sedation | 34.29 | 10.63 | 85 | 54070 | 16288 | 29882035 |
| Irritability | 32.82 | 10.63 | 104 | 54051 | 22946 | 29875377 |
| Sleep disorder | 32.64 | 10.63 | 108 | 54047 | 24371 | 29873952 |
| Akathisia | 31.88 | 10.63 | 46 | 54109 | 5858 | 29892465 |
| Hyperreflexia | 31.70 | 10.63 | 32 | 54123 | 2807 | 29895516 |
| Analgesic drug level above therapeutic | 31.37 | 10.63 | 13 | 54142 | 232 | 29898091 |
| Parkinsonism | 31.31 | 10.63 | 51 | 54104 | 7218 | 29891105 |
| Accidental overdose | 31.27 | 10.63 | 88 | 54067 | 18187 | 29880136 |
| Psychotic disorder | 29.65 | 10.63 | 96 | 54059 | 21419 | 29876904 |
| Multiple organ dysfunction syndrome | 29.61 | 10.63 | 43 | 54112 | 63444 | 29834879 |
| Delusion of replacement | 29.58 | 10.63 | 11 | 54144 | 145 | 29898178 |
| Cardiac failure | 29.52 | 10.63 | 67 | 54088 | 83351 | 29814972 |
| Disease progression | 29.21 | 10.63 | 63 | 54092 | 79811 | 29818512 |
| Environmental exposure | 29.05 | 10.63 | 13 | 54142 | 282 | 29898041 |
| Nightmare | 28.86 | 10.63 | 66 | 54089 | 12010 | 29886313 |
| Painful erection | 28.82 | 10.63 | 12 | 54143 | 217 | 29898106 |
| Granulocytopenia | 28.62 | 10.63 | 45 | 54110 | 6181 | 29892142 |
| Delirium | 28.48 | 10.63 | 147 | 54008 | 40484 | 29857839 |
| Penis injury | 27.94 | 10.63 | 12 | 54143 | 235 | 29898088 |
| Hyperhidrosis | 27.74 | 10.63 | 212 | 53943 | 66878 | 29831445 |
| Bradyphrenia | 27.73 | 10.63 | 35 | 54120 | 3922 | 29894401 |
| Withdrawal syndrome | 27.46 | 10.63 | 62 | 54093 | 11188 | 29887135 |
| Bipolar disorder | 27.42 | 10.63 | 34 | 54121 | 3742 | 29894581 |
| Sepsis | 27.40 | 10.63 | 154 | 54001 | 146241 | 29752082 |
| Cytomegalovirus infection | 27.08 | 10.63 | 5 | 54150 | 23669 | 29874654 |
| Hallucination, visual | 26.99 | 10.63 | 77 | 54078 | 16036 | 29882287 |
| Delusion | 26.98 | 10.63 | 64 | 54091 | 11925 | 29886398 |
| Clonus | 25.95 | 10.63 | 27 | 54128 | 2454 | 29895869 |
| Atrial fibrillation | 25.93 | 10.63 | 104 | 54051 | 108020 | 29790303 |
| Nervousness | 25.53 | 10.63 | 62 | 54093 | 11726 | 29886597 |
| Dysphoria | 25.44 | 10.63 | 25 | 54130 | 2123 | 29896200 |
| Erectile dysfunction | 25.15 | 10.63 | 81 | 54074 | 18021 | 29880302 |
| Drug reaction with eosinophilia and systemic symptoms | 25.13 | 10.63 | 10 | 54145 | 28478 | 29869845 |
| Acute kidney injury | 24.97 | 10.63 | 347 | 53808 | 273495 | 29624828 |
| Compulsive sexual behaviour | 24.57 | 10.63 | 11 | 54144 | 239 | 29898084 |
| Neuroleptic malignant syndrome | 24.56 | 10.63 | 75 | 54080 | 16220 | 29882103 |
| Homicide | 24.45 | 10.63 | 18 | 54137 | 1028 | 29897295 |
| Sexual dysfunction | 24.36 | 10.63 | 41 | 54114 | 5960 | 29892363 |
| Platelet count decreased | 24.26 | 10.63 | 104 | 54051 | 106025 | 29792298 |
| Polymerase chain reaction | 23.87 | 10.63 | 8 | 54147 | 76 | 29898247 |
| Fall | 23.74 | 10.63 | 461 | 53694 | 181411 | 29716912 |
| Erection increased | 23.42 | 10.63 | 14 | 54141 | 562 | 29897761 |
| Urine amphetamine positive | 23.38 | 10.63 | 6 | 54149 | 19 | 29898304 |
| Persistent depressive disorder | 23.37 | 10.63 | 11 | 54144 | 269 | 29898054 |
| Pruritus genital | 23.36 | 10.63 | 13 | 54142 | 455 | 29897868 |
| Post-traumatic stress disorder | 23.36 | 10.63 | 21 | 54134 | 1594 | 29896729 |
| Initial insomnia | 23.26 | 10.63 | 26 | 54129 | 2563 | 29895760 |
| Hallucination | 22.55 | 10.63 | 159 | 53996 | 48900 | 29849423 |
| Malignant neoplasm progression | 22.50 | 10.63 | 62 | 54093 | 72225 | 29826098 |
| Dry mouth | 22.20 | 10.63 | 91 | 54064 | 22759 | 29875564 |
| Substance abuse | 22.08 | 10.63 | 43 | 54112 | 6997 | 29891326 |
| Dyspnoea | 22.01 | 10.63 | 448 | 53707 | 332847 | 29565476 |
| Depersonalisation/derealisation disorder | 21.93 | 10.63 | 13 | 54142 | 514 | 29897809 |
| Injection site reaction | 21.63 | 10.63 | 55 | 54100 | 10705 | 29887618 |
| Cholestasis | 21.62 | 10.63 | 9 | 54146 | 24941 | 29873382 |
| Thinking abnormal | 21.18 | 10.63 | 36 | 54119 | 5275 | 29893048 |
| Euphoric mood | 21.11 | 10.63 | 32 | 54123 | 4258 | 29894065 |
| Bone marrow failure | 21.01 | 10.63 | 14 | 54141 | 29771 | 29868552 |
| Cogwheel rigidity | 20.99 | 10.63 | 17 | 54138 | 1119 | 29897204 |
| Hallucination, auditory | 20.68 | 10.63 | 51 | 54104 | 9738 | 29888585 |
| Drug screen positive | 20.46 | 10.63 | 32 | 54123 | 4375 | 29893948 |
| Restless legs syndrome | 20.38 | 10.63 | 41 | 54114 | 6831 | 29891492 |
| Dementia | 20.34 | 10.63 | 59 | 54096 | 12402 | 29885921 |
| Poor feeding infant | 20.17 | 10.63 | 11 | 54144 | 370 | 29897953 |
| Poor quality sleep | 20.06 | 10.63 | 42 | 54113 | 7199 | 29891124 |
| Nicotine dependence | 19.78 | 10.63 | 10 | 54145 | 287 | 29898036 |
| Abnormal behaviour | 19.57 | 10.63 | 95 | 54060 | 25528 | 29872795 |
| Food aversion | 19.47 | 10.63 | 10 | 54145 | 297 | 29898026 |
| Mucosal inflammation | 19.35 | 10.63 | 16 | 54139 | 30478 | 29867845 |
| Drug dependence | 19.28 | 10.63 | 83 | 54072 | 21212 | 29877111 |
| Haemoglobin decreased | 19.24 | 10.63 | 124 | 54031 | 113974 | 29784349 |
| Catatonia | 19.23 | 10.63 | 31 | 54124 | 4349 | 29893974 |
| Muscle rigidity | 19.14 | 10.63 | 51 | 54104 | 10210 | 29888113 |
| Obsessive thoughts | 19.05 | 10.63 | 13 | 54142 | 658 | 29897665 |
| Myotonia | 18.92 | 10.63 | 6 | 54149 | 47 | 29898276 |
| Psychomotor hyperactivity | 18.61 | 10.63 | 44 | 54111 | 8180 | 29890143 |
| Illness anxiety disorder | 18.29 | 10.63 | 8 | 54147 | 164 | 29898159 |
| Acute myeloid leukaemia | 18.20 | 10.63 | 5 | 54150 | 18001 | 29880322 |
| Lung disorder | 18.20 | 10.63 | 18 | 54137 | 31451 | 29866872 |
| Infection | 18.14 | 10.63 | 76 | 54079 | 77998 | 29820325 |
| Congenital pneumonia | 18.13 | 10.63 | 7 | 54148 | 103 | 29898220 |
| Hepatic failure | 17.98 | 10.63 | 21 | 54134 | 34022 | 29864301 |
| Hepatocellular injury | 17.93 | 10.63 | 12 | 54143 | 25459 | 29872864 |
| Drug resistance | 17.87 | 10.63 | 7 | 54148 | 20126 | 29878197 |
| C-reactive protein increased | 17.86 | 10.63 | 32 | 54123 | 43441 | 29854882 |
| Rash maculo-papular | 17.85 | 10.63 | 12 | 54143 | 25406 | 29872917 |
| Substance use disorder | 17.82 | 10.63 | 7 | 54148 | 108 | 29898215 |
| Penile haemorrhage | 17.69 | 10.63 | 12 | 54143 | 601 | 29897722 |
| Hangover | 17.56 | 10.63 | 15 | 54140 | 1063 | 29897260 |
| Depressed mood | 17.48 | 10.63 | 69 | 54086 | 16960 | 29881363 |
| Ascites | 17.07 | 10.63 | 24 | 54131 | 35897 | 29862426 |
| Procedural failure | 17.03 | 10.63 | 6 | 54149 | 67 | 29898256 |
| Lethargy | 16.95 | 10.63 | 126 | 54029 | 39393 | 29858930 |
| Generalised anxiety disorder | 16.86 | 10.63 | 12 | 54143 | 650 | 29897673 |
| Sleep-related eating disorder | 16.82 | 10.63 | 9 | 54146 | 291 | 29898032 |
| Blood cholinesterase decreased | 16.74 | 10.63 | 7 | 54148 | 128 | 29898195 |
| Myocardial infarction | 16.67 | 10.63 | 146 | 54009 | 125479 | 29772844 |
| Personality disorder | 16.67 | 10.63 | 15 | 54140 | 1140 | 29897183 |
| Respiratory failure | 16.65 | 10.63 | 110 | 54045 | 100532 | 29797791 |
| Exposure via ingestion | 16.58 | 10.63 | 22 | 54133 | 2589 | 29895734 |
| Sleep deficit | 16.39 | 10.63 | 10 | 54145 | 417 | 29897906 |
| Brain injury | 16.33 | 10.63 | 33 | 54122 | 5515 | 29892808 |
| Neck pain | 16.25 | 10.63 | 78 | 54077 | 20866 | 29877457 |
| Cough | 16.24 | 10.63 | 147 | 54008 | 125495 | 29772828 |
| Myoclonus | 16.22 | 10.63 | 57 | 54098 | 13255 | 29885068 |
| Pre-existing condition improved | 16.13 | 10.63 | 19 | 54136 | 1982 | 29896341 |
| Rash | 16.11 | 10.63 | 247 | 53908 | 191642 | 29706681 |
| Homicidal ideation | 16.03 | 10.63 | 21 | 54134 | 2442 | 29895881 |
| Bite | 16.01 | 10.63 | 5 | 54150 | 37 | 29898286 |
| Amputation of penis | 15.95 | 10.63 | 3 | 54152 | 0 | 29898323 |
| Blood bilirubin increased | 15.94 | 10.63 | 26 | 54129 | 36610 | 29861713 |
| Stress at work | 15.89 | 10.63 | 7 | 54148 | 146 | 29898177 |
| Abnormal dreams | 15.81 | 10.63 | 41 | 54114 | 8074 | 29890249 |
| Product administered at inappropriate site | 15.70 | 10.63 | 17 | 54138 | 1618 | 29896705 |
| Hostility | 15.66 | 10.63 | 13 | 54142 | 886 | 29897437 |
| Economic problem | 15.50 | 10.63 | 16 | 54139 | 1441 | 29896882 |
| Weight increased | 15.45 | 10.63 | 205 | 53950 | 74708 | 29823615 |
| Obsessive-compulsive disorder | 15.12 | 10.63 | 27 | 54128 | 4114 | 29894209 |
| Disorientation | 15.12 | 10.63 | 103 | 54052 | 31315 | 29867008 |
| Pneumocystis jirovecii pneumonia | 15.12 | 10.63 | 6 | 54149 | 17114 | 29881209 |
| Blood creatinine increased | 15.04 | 10.63 | 100 | 54055 | 91275 | 29807048 |
| Intestinal obstruction | 15.00 | 10.63 | 8 | 54147 | 19204 | 29879119 |
| Drug tolerance | 14.95 | 10.63 | 19 | 54136 | 2143 | 29896180 |
| Penile vein thrombosis | 14.67 | 10.63 | 4 | 54151 | 17 | 29898306 |
| Lower respiratory tract infection | 14.63 | 10.63 | 16 | 54139 | 26698 | 29871625 |
| Dyskinesia | 14.61 | 10.63 | 78 | 54077 | 21756 | 29876567 |
| Bruxism | 14.60 | 10.63 | 15 | 54140 | 1344 | 29896979 |
| Homeless | 14.48 | 10.63 | 4 | 54151 | 18 | 29898305 |
| Periorbital haemorrhage | 14.33 | 10.63 | 6 | 54149 | 110 | 29898213 |
| C-reactive protein | 14.23 | 10.63 | 6 | 54149 | 112 | 29898211 |
| Self-injurious ideation | 14.19 | 10.63 | 16 | 54139 | 1593 | 29896730 |
| Jaundice | 14.18 | 10.63 | 23 | 54132 | 32463 | 29865860 |
| Shock | 14.18 | 10.63 | 80 | 54075 | 22779 | 29875544 |
| Dysarthria | 14.11 | 10.63 | 99 | 54056 | 30391 | 29867932 |
| Extrapyramidal disorder | 14.09 | 10.63 | 47 | 54108 | 10646 | 29887677 |
| Hanging | 14.09 | 10.63 | 6 | 54149 | 115 | 29898208 |
| Flat affect | 14.07 | 10.63 | 12 | 54143 | 849 | 29897474 |
| Hypertonia | 14.02 | 10.63 | 27 | 54128 | 4358 | 29893965 |
| Foaming at mouth | 14.01 | 10.63 | 11 | 54144 | 692 | 29897631 |
| Product dose omission issue | 13.94 | 10.63 | 238 | 53917 | 91393 | 29806930 |
| Sleep sex | 13.88 | 10.63 | 3 | 54152 | 3 | 29898320 |
| Peritonitis | 13.83 | 10.63 | 11 | 54144 | 21364 | 29876959 |
| White blood cell count decreased | 13.75 | 10.63 | 92 | 54063 | 83855 | 29814468 |
| Disseminated intravascular coagulation | 13.62 | 10.63 | 12 | 54143 | 22159 | 29876164 |
| Eosinophilia | 13.61 | 10.63 | 12 | 54143 | 22148 | 29876175 |
| Cardiac failure congestive | 13.58 | 10.63 | 93 | 54062 | 84314 | 29814009 |
| Unresponsive to stimuli | 13.55 | 10.63 | 88 | 54067 | 26331 | 29871992 |
| Memory impairment | 13.46 | 10.63 | 114 | 54041 | 37060 | 29861263 |
| Diabetic foetopathy | 13.30 | 10.63 | 7 | 54148 | 219 | 29898104 |
| Urine leukocyte esterase positive | 13.23 | 10.63 | 8 | 54147 | 328 | 29897995 |
| Bronchopulmonary aspergillosis | 13.21 | 10.63 | 3 | 54152 | 12281 | 29886042 |
| Penile necrosis | 13.17 | 10.63 | 5 | 54150 | 70 | 29898253 |
| Erythema | 13.13 | 10.63 | 84 | 54071 | 77367 | 29820956 |
| Panic attack | 13.12 | 10.63 | 40 | 54115 | 8641 | 29889682 |
| Toxicologic test abnormal | 13.11 | 10.63 | 10 | 54145 | 603 | 29897720 |
| Alcohol use | 13.10 | 10.63 | 24 | 54131 | 3731 | 29894592 |
| Amnesia | 13.08 | 10.63 | 82 | 54073 | 24239 | 29874084 |
| Alcohol poisoning | 13.06 | 10.63 | 24 | 54131 | 3740 | 29894583 |
| Myelodysplastic syndrome | 13.01 | 10.63 | 9 | 54146 | 18769 | 29879554 |
| Reduced facial expression | 13.01 | 10.63 | 11 | 54144 | 769 | 29897554 |
| Dizziness | 13.00 | 10.63 | 452 | 53703 | 194457 | 29703866 |
| Ephelides | 12.98 | 10.63 | 5 | 54150 | 73 | 29898250 |
| Withdrawal catatonia | 12.98 | 10.63 | 5 | 54150 | 73 | 29898250 |
| Osteonecrosis of jaw | 12.80 | 10.63 | 9 | 54146 | 18609 | 29879714 |
| Drug abuser | 12.75 | 10.63 | 26 | 54129 | 4375 | 29893948 |
| Paedophilia | 12.67 | 10.63 | 3 | 54152 | 6 | 29898317 |
| Delirium febrile | 12.65 | 10.63 | 4 | 54151 | 31 | 29898292 |
| Wrong patient received product | 12.62 | 10.63 | 16 | 54139 | 1801 | 29896522 |
| General symptom | 12.46 | 10.63 | 11 | 54144 | 815 | 29897508 |
| Alanine aminotransferase increased | 12.37 | 10.63 | 81 | 54074 | 74195 | 29824128 |
| Pneumonia | 12.36 | 10.63 | 487 | 53668 | 333819 | 29564504 |
| Obsessive rumination | 12.35 | 10.63 | 3 | 54152 | 7 | 29898316 |
| Libido increased | 12.26 | 10.63 | 11 | 54144 | 833 | 29897490 |
| Pleural effusion | 12.22 | 10.63 | 81 | 54074 | 73985 | 29824338 |
| Discoloured vomit | 12.14 | 10.63 | 8 | 54147 | 382 | 29897941 |
| Psychomotor retardation | 12.07 | 10.63 | 18 | 54137 | 2361 | 29895962 |
| Vascular encephalopathy | 12.03 | 10.63 | 5 | 54150 | 90 | 29898233 |
| Heat stroke | 11.97 | 10.63 | 11 | 54144 | 859 | 29897464 |
| Major depression | 11.93 | 10.63 | 24 | 54131 | 3998 | 29894325 |
| Toxic epidermal necrolysis | 11.90 | 10.63 | 9 | 54146 | 17931 | 29880392 |
| Palmar-plantar erythrodysaesthesia syndrome | 11.89 | 10.63 | 6 | 54149 | 14864 | 29883459 |
| Pruritus | 11.75 | 10.63 | 147 | 54008 | 118057 | 29780266 |
| Terminal insomnia | 11.68 | 10.63 | 8 | 54147 | 407 | 29897916 |
| Product reconstitution quality issue | 11.59 | 10.63 | 5 | 54150 | 99 | 29898224 |
| Feeling abnormal | 11.57 | 10.63 | 155 | 54000 | 56601 | 29841722 |
| Thyroiditis acute | 11.32 | 10.63 | 5 | 54150 | 105 | 29898218 |
| Foetal exposure during pregnancy | 11.19 | 10.63 | 32 | 54123 | 36839 | 29861484 |
| Feelings of worthlessness | 11.08 | 10.63 | 6 | 54149 | 199 | 29898124 |
| Gambling disorder | 10.92 | 10.63 | 15 | 54140 | 1825 | 29896498 |
| Sinus bradycardia | 10.90 | 10.63 | 46 | 54109 | 11649 | 29886674 |
| Ejaculation failure | 10.80 | 10.63 | 10 | 54145 | 788 | 29897535 |
| Alcohol withdrawal syndrome | 10.76 | 10.63 | 14 | 54141 | 1617 | 29896706 |
| Drug withdrawal syndrome neonatal | 10.71 | 10.63 | 20 | 54135 | 3155 | 29895168 |
| Device related infection | 10.71 | 10.63 | 9 | 54146 | 17006 | 29881317 |
| Colitis | 10.69 | 10.63 | 25 | 54130 | 30795 | 29867528 |
| Bipolar I disorder | 10.69 | 10.63 | 10 | 54145 | 799 | 29897524 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N06AX05 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Other antidepressants |
| FDA EPC | N0000175696 | Serotonin Reuptake Inhibitor |
| MeSH PA | D014151 | Anti-Anxiety Agents |
| MeSH PA | D000928 | Antidepressive Agents |
| MeSH PA | D018687 | Antidepressive Agents, Second-Generation |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D049990 | Membrane Transport Modulators |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
| MeSH PA | D011619 | Psychotropic Drugs |
| MeSH PA | D018490 | Serotonin Agents |
| MeSH PA | D017367 | Serotonin Uptake Inhibitors |
| MeSH PA | D014149 | Tranquilizing Agents |
| CHEBI has role | CHEBI:35469 | thymoanaleptics |
| CHEBI has role | CHEBI:35474 | minor tranquilisers |
| CHEBI has role | CHEBI:35717 | sedatives |
| CHEBI has role | CHEBI:37887 | adrenergic receptor blockaders |
| CHEBI has role | CHEBI:37955 | h1-receptor blockers |
| CHEBI has role | CHEBI:50949 | serotonin reuptake inhibitor |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Major depressive disorder | indication | 370143000 | |
| Insomnia | off-label use | 193462001 | |
| Priapism | contraindication | 6273006 | DOID:9286 |
| Suicidal thoughts | contraindication | 6471006 | |
| Orthostatic hypotension | contraindication | 28651003 | |
| Torsades de pointes | contraindication | 31722008 | |
| Hypokalemia | contraindication | 43339004 | |
| Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
| Heart disease | contraindication | 56265001 | DOID:114 |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Prolonged QT interval | contraindication | 111975006 | |
| Hypomagnesemia | contraindication | 190855004 | |
| Benign prostatic hyperplasia | contraindication | 266569009 | |
| Myocardial infarction in recovery phase | contraindication | 418044006 | |
| Congenital long QT syndrome | contraindication | 442917000 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.98 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2C | GPCR | ANTAGONIST | Ki | 6.65 | WOMBAT-PK | CHEMBL | |||
| 5-hydroxytryptamine receptor 2A | GPCR | ANTAGONIST | Ki | 7.35 | WOMBAT-PK | CHEMBL | |||
| Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Kd | 6.80 | WOMBAT-PK | CHEMBL | |||
| Alpha-2C adrenergic receptor | GPCR | Ki | 6.81 | PDSP | |||||
| Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.03 | DRUG MATRIX | |||||
| Alpha-2B adrenergic receptor | GPCR | Ki | 6.75 | DRUG MATRIX | |||||
| D(3) dopamine receptor | GPCR | Ki | 5.90 | DRUG MATRIX | |||||
| Alpha-1D adrenergic receptor | GPCR | Ki | 7.33 | DRUG MATRIX | |||||
| Sodium-dependent dopamine transporter | Transporter | Kd | 5.13 | WOMBAT-PK | |||||
| Histamine H1 receptor | GPCR | Ki | 6.21 | WOMBAT-PK | |||||
| Alpha-1A adrenergic receptor | GPCR | IC50 | 9.55 | WOMBAT-PK | |||||
| 5-hydroxytryptamine receptor 2B | GPCR | Ki | 7.08 | WOMBAT-PK | |||||
| 5-hydroxytryptamine receptor 1A | GPCR | Ki | 7.02 | WOMBAT-PK | |||||
| Sodium-dependent noradrenaline transporter | Transporter | Kd | 5.07 | WOMBAT-PK | |||||
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.54 | WOMBAT-PK | |||||
| Alpha-2A adrenergic receptor | GPCR | Ki | 6.58 | WOMBAT-PK | |||||
| D(4) dopamine receptor | GPCR | Ki | 6.15 | PDSP | |||||
| 5-hydroxytryptamine receptor 7 | GPCR | Ki | 5.75 | PDSP | |||||
| D(2) dopamine receptor | GPCR | Ki | 5.46 | PDSP | |||||
| D(1A) dopamine receptor | GPCR | Ki | 5.43 | PDSP | |||||
| 5-hydroxytryptamine receptor 1D | GPCR | Ki | 6.97 | PDSP | |||||
| Histamine H2 receptor | GPCR | Ki | 5.48 | PDSP | |||||
| Alpha-1B adrenergic receptor | GPCR | Ki | 7.21 | DRUG MATRIX | |||||
| 5-hydroxytryptamine receptor 1B | GPCR | Ki | 6.08 | DRUG MATRIX | |||||
| Membrane-associated progesterone receptor component 1 | Membrane receptor | Ki | 6.08 | DRUG MATRIX | |||||
| 5-hydroxytryptamine receptor 2A | GPCR | IC50 | 7.77 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 1A | GPCR | Ki | 6.65 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 2C | GPCR | ANTAGONIST | Ki | 6.70 | IUPHAR | ||||
| Alpha-1A adrenergic receptor | GPCR | IC50 | 6.93 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019954 | VUID |
| N0000148039 | NUI |
| D00820 | KEGG_DRUG |
| 25332-39-2 | SECONDARY_CAS_RN |
| 4018812 | VANDF |
| 4019954 | VANDF |
| C0040805 | UMLSCUI |
| CHEBI:9654 | CHEBI |
| CHEMBL621 | ChEMBL_ID |
| CHEMBL1200798 | ChEMBL_ID |
| D014196 | MESH_DESCRIPTOR_UI |
| 2878 | INN_ID |
| DB00656 | DRUGBANK_ID |
| YBK48BXK30 | UNII |
| 5533 | PUBCHEM_CID |
| 213 | IUPHAR_LIGAND_ID |
| 10737 | RXNORM |
| 1504 | MMSL |
| 5609 | MMSL |
| d00395 | MMSL |
| 001511 | NDDF |
| 004610 | NDDF |
| 372829000 | SNOMEDCT_US |
| 58956008 | SNOMEDCT_US |
| 7336002 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0733 | TABLET | 300 mg | ORAL | ANDA | 26 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-6160 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 29 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-6161 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 29 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-2578 | TABLET | 50 mg | ORAL | ANDA | 31 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-2579 | TABLET | 100 mg | ORAL | ANDA | 31 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8155 | TABLET | 150 mg | ORAL | ANDA | 30 sections |
| TRAZODONE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8339 | TABLET | 150 mg | ORAL | ANDA | 31 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8371 | TABLET | 50 mg | ORAL | ANDA | 30 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8386 | TABLET | 100 mg | ORAL | ANDA | 30 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6554 | TABLET | 50 mg | ORAL | ANDA | 21 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6555 | TABLET | 100 mg | ORAL | ANDA | 21 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6868 | TABLET | 50 mg | ORAL | ANDA | 27 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6869 | TABLET | 100 mg | ORAL | ANDA | 27 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-532 | TABLET | 100 mg | ORAL | ANDA | 31 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-533 | TABLET | 150 mg | ORAL | ANDA | 24 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-534 | TABLET | 50 mg | ORAL | ANDA | 30 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-867 | TABLET | 150 mg | ORAL | ANDA | 21 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-193 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 31 sections |
| Trazodone Hydrochloride | Human Prescription Drug Label | 1 | 13107-079 | TABLET | 50 mg | ORAL | ANDA | 29 sections |
| Trazodone Hydrochloride | Human Prescription Drug Label | 1 | 13107-080 | TABLET | 100 mg | ORAL | ANDA | 29 sections |
| Trazodone Hydrochloride | Human Prescription Drug Label | 1 | 13107-081 | TABLET | 150 mg | ORAL | ANDA | 29 sections |
| Trazodone Hydrochloride | Human Prescription Drug Label | 1 | 13107-082 | TABLET | 300 mg | ORAL | ANDA | 29 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-330 | TABLET | 50 mg | ORAL | ANDA | 22 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-331 | TABLET | 100 mg | ORAL | ANDA | 22 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-332 | TABLET | 150 mg | ORAL | ANDA | 22 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-333 | TABLET | 300 mg | ORAL | ANDA | 22 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-231 | TABLET | 50 mg | ORAL | ANDA | 25 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-232 | TABLET | 100 mg | ORAL | ANDA | 25 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-585 | TABLET | 150 mg | ORAL | ANDA | 25 sections |
| Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-299 | TABLET | 50 mg | ORAL | ANDA | 20 sections |