trazodone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2717 19794-93-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • trazodone
  • trazodon
  • trazodone hydrochloride
  • trazodone HCl
A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
  • Molecular weight: 371.87
  • Formula: C19H22ClN5O
  • CLOGP: 3.85
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 42.39
  • ALOGS: -3.11
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.20 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 23.05 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 81 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.52 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.40 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.08 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 24, 1981 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1266.84 9.74 1653 110663 144267 46429479
Drug abuse 517.36 9.74 698 111618 62710 46511036
Toxicity to various agents 421.60 9.74 1291 111025 210475 46363271
Serotonin syndrome 356.08 9.74 361 111955 23859 46549887
Sopor 314.47 9.74 308 112008 19520 46554226
Respiratory arrest 232.21 9.74 343 111973 33473 46540273
Suicidal ideation 194.11 9.74 423 111893 55959 46517787
Cardio-respiratory arrest 185.81 9.74 431 111885 59438 46514308
Depression 171.24 9.74 836 111480 169268 46404478
Suicide attempt 155.44 9.74 382 111934 54654 46519092
Overdose 154.63 9.74 568 111748 101411 46472335
Poisoning 124.69 9.74 161 112155 13833 46559913
Rheumatoid arthritis 118.06 9.74 251 112065 239964 46333782
Insomnia 115.42 9.74 735 111581 164189 46409557
Cardiac arrest 113.85 9.74 475 111841 89924 46483822
Presbyacusis 97.80 9.74 69 112247 2753 46570993
Maternal exposure during pregnancy 92.52 9.74 67 112249 102482 46471264
Pleural thickening 88.89 9.74 63 112253 2532 46571214
Pleural fibrosis 87.59 9.74 71 112245 3498 46570248
Hypomania 86.58 9.74 77 112239 4311 46569435
Anxiety 85.61 9.74 738 111578 181219 46392527
Neutropenia 84.18 9.74 134 112182 143070 46430676
Agitation 83.37 9.74 308 112008 55107 46518639
Blood magnesium increased 82.40 9.74 64 112252 2963 46570783
Electrocardiogram QT prolonged 81.21 9.74 290 112026 51035 46522711
Drug withdrawal syndrome 78.26 9.74 191 112125 27193 46546553
Irritability 77.57 9.74 197 112119 28749 46544997
Tremor 72.73 9.74 502 111814 115137 46458609
Deafness neurosensory 71.58 9.74 70 112246 4424 46569322
Exposure during pregnancy 67.69 9.74 97 112219 108115 46465631
Anaemia 65.38 9.74 355 111961 255424 46318322
Thrombocytopenia 64.86 9.74 129 112187 126452 46447294
Withdrawal syndrome 64.59 9.74 138 112178 17996 46555750
Febrile neutropenia 63.04 9.74 81 112235 94546 46479200
Psychotic disorder 59.62 9.74 153 112163 22468 46551278
Schizophrenia 58.91 9.74 87 112229 8481 46565265
Epigastric discomfort 58.00 9.74 70 112246 5614 46568132
Myocardial stunning 57.64 9.74 20 112296 155 46573591
Hand deformity 56.47 9.74 8 112308 34566 46539180
Systemic lupus erythematosus 55.69 9.74 45 112271 65135 46508611
Malignant neoplasm progression 55.25 9.74 45 112271 64881 46508865
Synovitis 54.94 9.74 40 112276 61035 46512711
Tardive dyskinesia 53.90 9.74 78 112238 7465 46566281
Intentional overdose 53.36 9.74 302 112014 64642 46509104
Mucosal inflammation 53.17 9.74 14 112302 38962 46534784
Joint swelling 52.08 9.74 214 112102 165859 46407887
Sedation 51.38 9.74 146 112170 22764 46550982
Contraindicated product administered 50.64 9.74 71 112245 79876 46493870
General physical health deterioration 50.33 9.74 129 112187 115640 46458106
Infusion related reaction 50.26 9.74 105 112211 101103 46472643
Drug screen positive 48.26 9.74 53 112263 3838 46569908
Jaundice cholestatic 48.18 9.74 60 112256 4969 46568777
Drug intolerance 47.04 9.74 188 112128 146861 46426885
Drug interaction 46.44 9.74 716 111600 202378 46371368
Migraine 46.39 9.74 308 112008 69718 46504028
Pyrexia 45.96 9.74 578 111738 348224 46225522
Haemoglobin decreased 45.05 9.74 159 112157 128790 46444956
Rash 45.05 9.74 596 111720 355916 46217830
Depressed level of consciousness 44.35 9.74 229 112087 47340 46526406
Akathisia 44.19 9.74 72 112244 7642 46566104
Pancytopenia 44.14 9.74 86 112230 84972 46488774
Bone marrow failure 43.76 9.74 9 112307 29660 46544086
Hyperreflexia 43.02 9.74 58 112258 5196 46568550
Visual perseveration 42.79 9.74 13 112303 62 46573684
Nightmare 42.44 9.74 111 112205 16487 46557259
Acute kidney injury 41.56 9.74 365 111951 235490 46338256
Asphyxia 40.90 9.74 57 112259 5269 46568477
Cardiac failure 40.48 9.74 82 112234 79866 46493880
Bone cyst 40.48 9.74 36 112280 2015 46571731
Sleep disorder 40.03 9.74 220 112096 46575 46527171
Anger 39.70 9.74 88 112228 11764 46561982
Accidental poisoning 39.20 9.74 22 112294 583 46573163
Osteopenia 38.92 9.74 109 112207 16852 46556894
Swelling 38.67 9.74 161 112155 124350 46449396
Memory impairment 38.05 9.74 317 111999 77020 46496726
Multiple sclerosis relapse 38.03 9.74 201 112115 41924 46531822
Muscle rigidity 38.03 9.74 78 112238 9883 46563863
Suspected suicide 37.47 9.74 51 112265 4610 46569136
Treatment failure 37.24 9.74 108 112208 92979 46480767
Adjustment disorder with mixed anxiety and depressed mood 36.93 9.74 12 112304 74 46573672
Intentional self-injury 36.90 9.74 135 112181 24031 46549715
Abnormal behaviour 36.79 9.74 123 112193 20935 46552811
Leukopenia 35.55 9.74 69 112247 68274 46505472
Cyst 35.21 9.74 85 112231 12015 46561731
Torsade de pointes 34.96 9.74 85 112231 12069 46561677
Mental disorder 34.85 9.74 126 112190 22299 46551447
Pleurothotonus 34.72 9.74 26 112290 1139 46572607
Somatic delusion 33.62 9.74 20 112296 593 46573153
Sepsis 33.48 9.74 191 112125 135823 46437923
Platelet count decreased 33.17 9.74 126 112190 99898 46473848
Polycystic ovaries 32.84 9.74 27 112289 1357 46572389
Oral discomfort 32.62 9.74 64 112252 7854 46565892
Toxic epidermal necrolysis 32.36 9.74 7 112309 22271 46551475
Injection site mass 31.94 9.74 94 112222 14946 46558800
Affective disorder 31.83 9.74 48 112268 4767 46568979
Intentional product misuse 31.63 9.74 208 112108 46920 46526826
Priapism 31.47 9.74 7 112309 5 46573741
Arteriosclerosis coronary artery 31.30 9.74 64 112252 8092 46565654
Cholestasis 30.85 9.74 13 112303 26880 46546866
Osteosclerosis 30.61 9.74 40 112276 3476 46570270
Blood prolactin increased 30.43 9.74 37 112279 2990 46570756
Dyskinesia 30.33 9.74 144 112172 28781 46544965
Pericarditis 30.07 9.74 10 112306 23917 46549829
Confusional state 30.02 9.74 546 111770 159346 46414400
C-reactive protein increased 29.74 9.74 60 112256 58530 46515216
Confabulation 29.64 9.74 14 112302 256 46573490
Hereditary angioedema 29.60 9.74 50 112266 5466 46568280
Blood potassium increased 29.55 9.74 99 112217 16868 46556878
Dissociation 29.45 9.74 29 112287 1848 46571898
Unresponsive to stimuli 29.37 9.74 154 112162 32020 46541726
Bradyphrenia 28.94 9.74 53 112263 6177 46567569
Mental status changes 28.61 9.74 173 112143 37915 46535831
Psychomotor hyperactivity 28.48 9.74 68 112248 9545 46564201
Hepatocellular injury 28.33 9.74 18 112298 29504 46544242
Mood altered 28.30 9.74 82 112234 12925 46560821
Substance abuse 28.20 9.74 42 112274 4125 46569621
Cytomegalovirus infection 27.82 9.74 5 112311 18139 46555607
Weight increased 27.24 9.74 551 111765 163922 46409824
Wound 27.11 9.74 38 112278 42764 46530982
Abnormal dreams 26.54 9.74 69 112247 10210 46563536
Accidental death 26.31 9.74 27 112289 1808 46571938
Pneumocystis jirovecii pneumonia 26.18 9.74 3 112313 15245 46558501
Tachyphrenia 26.11 9.74 23 112293 1271 46572475
Disease progression 25.95 9.74 122 112194 91178 46482568
Balance disorder 25.86 9.74 253 112063 64268 46509478
Premature baby 25.68 9.74 6 112310 18106 46555640
Hyperkalaemia 25.67 9.74 52 112264 50657 46523089
Tearfulness 25.61 9.74 40 112276 4095 46569651
Pleural effusion 25.29 9.74 108 112208 82844 46490902
Skin lesion 25.17 9.74 129 112187 26584 46547162
Peripheral swelling 25.08 9.74 251 112065 157820 46415926
Bipolar disorder 24.85 9.74 54 112262 7123 46566623
Device expulsion 24.81 9.74 18 112298 27524 46546222
Premature delivery 24.79 9.74 11 112305 22058 46551688
Exostosis 24.58 9.74 67 112249 10196 46563550
Multiple organ dysfunction syndrome 24.53 9.74 55 112261 51655 46522091
Neuroleptic malignant syndrome 24.08 9.74 70 112246 11052 46562694
Septic shock 24.01 9.74 66 112250 57827 46515919
Plasma cell myeloma 23.92 9.74 44 112272 44434 46529312
Major depression 23.92 9.74 51 112265 6639 46567107
Aggression 23.68 9.74 113 112203 22631 46551115
Fibromyalgia 23.31 9.74 159 112157 36304 46537442
Drug reaction with eosinophilia and systemic symptoms 23.29 9.74 22 112294 29526 46544220
Rheumatoid factor positive 23.29 9.74 10 112306 20451 46553295
Somnolence 23.20 9.74 516 111800 156005 46417741
Hostility 23.17 9.74 22 112294 1340 46572406
Cardiac failure congestive 23.02 9.74 128 112188 91622 46482124
Depressed mood 22.93 9.74 148 112168 33171 46540575
Depressive symptom 22.75 9.74 31 112285 2805 46570941
Product dose omission issue 22.65 9.74 548 111768 167972 46405774
Stevens-Johnson syndrome 22.64 9.74 14 112302 23283 46550463
Hallucination, auditory 22.63 9.74 67 112249 10689 46563057
Alopecia 22.52 9.74 266 112050 162148 46411598
Hepatic function abnormal 22.36 9.74 30 112286 34391 46539355
Drug dependence 22.28 9.74 101 112215 19800 46553946
Exposure via ingestion 22.12 9.74 34 112282 3433 46570313
Alcoholism 22.12 9.74 27 112289 2191 46571555
Wound infection fungal 21.72 9.74 8 112308 75 46573671
Sensation of foreign body 21.72 9.74 36 112280 3875 46569871
Dry eye 21.68 9.74 136 112180 30186 46543560
Muscle twitching 21.59 9.74 81 112235 14591 46559155
Solar urticaria 21.57 9.74 7 112309 43 46573703
Abdominal discomfort 21.57 9.74 246 112070 150919 46422827
Galactorrhoea 21.15 9.74 35 112281 3762 46569984
Apallic syndrome 21.05 9.74 15 112301 608 46573138
Perseveration 21.05 9.74 11 112305 252 46573494
Off label use 20.71 9.74 727 111589 379114 46194632
Interstitial lung disease 20.56 9.74 64 112252 53885 46519861
Meningitis streptococcal 20.43 9.74 9 112307 139 46573607
Glossodynia 20.40 9.74 48 112268 44325 46529421
Abortion spontaneous 20.24 9.74 47 112269 43599 46530147
Hyper IgE syndrome 19.79 9.74 10 112306 213 46573533
Myoclonus 19.29 9.74 77 112239 14275 46559471
Vasoplegia syndrome 19.27 9.74 18 112298 1074 46572672
Poor quality sleep 19.05 9.74 80 112236 15173 46558573
Lung disorder 19.00 9.74 48 112268 43256 46530490
Atrial fibrillation 18.79 9.74 159 112157 103431 46470315
Plasma cell mastitis 18.79 9.74 5 112311 13 46573733
Fall 18.45 9.74 968 111348 328129 46245617
Periorbital swelling 18.43 9.74 19 112297 1279 46572467
Post-traumatic stress disorder 18.25 9.74 34 112282 4014 46569732
Oppositional defiant disorder 18.07 9.74 6 112310 40 46573706
Sleep apnoea syndrome 18.06 9.74 103 112213 22098 46551648
Lower respiratory tract infection 17.87 9.74 70 112246 55019 46518727
Compartment syndrome 17.81 9.74 23 112293 1976 46571770
Neutrophil count decreased 17.64 9.74 50 112266 43376 46530370
Body tinea 17.64 9.74 16 112300 919 46572827
Dysphoria 17.59 9.74 36 112280 4553 46569193
Marchiafava-Bignami disease 17.58 9.74 5 112311 18 46573728
Purple glove syndrome 17.55 9.74 9 112307 198 46573548
Nervousness 17.51 9.74 123 112193 28352 46545394
Restless legs syndrome 17.44 9.74 80 112236 15763 46557983
Metastases to liver 17.38 9.74 13 112303 19572 46554174
Sense of a foreshortened future 17.37 9.74 4 112312 4 46573742
Screaming 17.22 9.74 29 112287 3162 46570584
Alcohol withdrawal syndrome 17.14 9.74 15 112301 822 46572924
Sinus bradycardia 16.99 9.74 72 112244 13710 46560036
Red blood cell sedimentation rate increased 16.95 9.74 18 112298 22871 46550875
Homicidal ideation 16.47 9.74 21 112295 1781 46571965
Extrapyramidal disorder 16.41 9.74 62 112254 11206 46562540
Product use issue 16.40 9.74 147 112169 94497 46479249
Mood swings 16.38 9.74 80 112236 16172 46557574
Tonic clonic movements 16.36 9.74 17 112299 1155 46572591
Drug resistance 16.11 9.74 11 112305 17357 46556389
Mania 16.06 9.74 60 112256 10786 46562960
Heart rate abnormal 15.97 9.74 29 112287 3358 46570388
Cognitive disorder 15.95 9.74 147 112169 36736 46537010
Eczema eyelids 15.95 9.74 7 112309 107 46573639
Toxic skin eruption 15.88 9.74 5 112311 12382 46561364
Skin ulcer 15.83 9.74 34 112282 32424 46541322
Ascites 15.70 9.74 41 112275 36543 46537203
Neoplasm progression 15.63 9.74 25 112291 26658 46547088
Restlessness 15.54 9.74 110 112206 25414 46548332
Panic reaction 15.42 9.74 30 112286 3659 46570087
Face oedema 15.41 9.74 14 112302 19139 46554607
Renal failure 15.37 9.74 187 112129 113407 46460339
Sensitisation 15.30 9.74 13 112303 684 46573062
Crying 15.22 9.74 95 112221 21046 46552700
Coma 14.98 9.74 210 112106 58139 46515607
Anaphylactic shock 14.95 9.74 16 112300 20258 46553488
Feeling of despair 14.89 9.74 20 112296 1785 46571961
Angioedema 14.76 9.74 47 112269 39295 46534451
Haemangioma congenital 14.75 9.74 11 112305 479 46573267
Psychomotor skills impaired 14.74 9.74 22 112294 2164 46571582
Disorganised speech 14.69 9.74 14 112302 857 46572889
Rash maculo-papular 14.61 9.74 28 112288 27846 46545900
Mitral valve thickening 14.61 9.74 5 112311 37 46573709
Panic attack 14.60 9.74 91 112225 20151 46553595
Speech disorder 14.58 9.74 142 112174 36025 46537721
Obsessive-compulsive disorder 14.49 9.74 27 112289 3188 46570558
Arthropathy 14.48 9.74 132 112184 84568 46489178
Middle insomnia 14.39 9.74 53 112263 9462 46564284
Herpes zoster 14.27 9.74 100 112216 67772 46505974
Disturbance in attention 14.27 9.74 127 112189 31433 46542313
Injection site necrosis 14.27 9.74 17 112299 1345 46572401
Burning mouth syndrome 14.19 9.74 10 112306 398 46573348
Type 2 diabetes mellitus 14.12 9.74 89 112227 19786 46553960
Disseminated intravascular coagulation 14.01 9.74 15 112301 18990 46554756
Lethargy 13.89 9.74 186 112130 50985 46522761
Liver function test abnormal 13.87 9.74 61 112255 46426 46527320
Oedema peripheral 13.83 9.74 286 112030 159420 46414326
Chromaturia 13.78 9.74 72 112244 14947 46558799
Morbid thoughts 13.76 9.74 11 112305 531 46573215
Polyglandular autoimmune syndrome type II 13.76 9.74 5 112311 45 46573701
Initial insomnia 13.74 9.74 32 112284 4420 46569326
Spleen congestion 13.73 9.74 7 112309 152 46573594
Decreased interest 13.62 9.74 26 112290 3126 46570620
Therapeutic product effect decreased 13.57 9.74 130 112186 82471 46491275
Myoglobin blood increased 13.55 9.74 17 112299 1419 46572327
Skin texture abnormal 13.52 9.74 9 112307 326 46573420
Aspiration 13.51 9.74 52 112264 9479 46564267
Urticaria 13.44 9.74 201 112115 117691 46456055
Gambling disorder 13.29 9.74 16 112300 1280 46572466
Affect lability 13.26 9.74 46 112270 7974 46565772
Tongue discolouration 13.26 9.74 25 112291 2979 46570767
Granulocytopenia 13.21 9.74 35 112281 5238 46568508
Coagulopathy 13.20 9.74 15 112301 18484 46555262
Intervertebral disc degeneration 13.19 9.74 65 112251 13187 46560559
Gastrointestinal haemorrhage 13.04 9.74 121 112195 77252 46496494
Social avoidant behaviour 12.99 9.74 24 112292 2815 46570931
Ejection fraction 12.91 9.74 11 112305 581 46573165
Mydriasis 12.91 9.74 55 112261 10498 46563248
Rash erythematous 12.91 9.74 41 112275 34309 46539437
Feeling abnormal 12.89 9.74 393 111923 124667 46449079
Paranoia 12.79 9.74 55 112261 10542 46563204
Drug screen false positive 12.75 9.74 13 112303 864 46572882
Cerebral infarction 12.66 9.74 23 112293 23343 46550403
Slow speech 12.63 9.74 16 112300 1348 46572398
Encephalopathy 12.63 9.74 130 112186 33459 46540287
Self-injurious ideation 12.54 9.74 21 112295 2279 46571467
Borderline personality disorder 12.43 9.74 12 112304 746 46573000
Drug screen negative 12.43 9.74 9 112307 374 46573372
Drug ineffective 12.42 9.74 1435 110881 676403 45897343
Tracheitis 12.38 9.74 12 112304 750 46572996
Deformity 12.33 9.74 42 112274 7215 46566531
Stomatitis 12.31 9.74 105 112211 68192 46505554
Liver disorder 12.29 9.74 47 112269 37199 46536547
Osteonecrosis of jaw 12.28 9.74 42 112274 34360 46539386
Medication error 12.28 9.74 121 112195 30790 46542956
Personal relationship issue 12.27 9.74 4 112312 25 46573721
Hyperhidrosis 12.16 9.74 291 112025 89017 46484729
Palmar-plantar erythrodysaesthesia syndrome 12.13 9.74 19 112297 20432 46553314
Transplant rejection 12.08 9.74 4 112312 9592 46564154
Gastroenteritis radiation 12.07 9.74 10 112306 508 46573238
Peritoneal perforation 12.04 9.74 6 112310 124 46573622
Therapeutic product effect incomplete 12.01 9.74 125 112191 78028 46495718
Femur fracture 12.00 9.74 47 112269 36950 46536796
Inhibitory drug interaction 11.94 9.74 19 112297 1976 46571770
Anticholinergic syndrome 11.93 9.74 18 112298 1788 46571958
Thinking abnormal 11.89 9.74 51 112265 9763 46563983
Jaundice 11.87 9.74 33 112283 28812 46544934
Gamma-glutamyltransferase increased 11.85 9.74 38 112278 31702 46542044
Live birth 11.84 9.74 5 112311 10325 46563421
Nephrectomy 11.79 9.74 10 112306 525 46573221
Skin sensitisation 11.73 9.74 12 112304 801 46572945
Dyspnoea 11.66 9.74 1075 111241 514473 46059273
Holmes-Adie pupil 11.53 9.74 4 112312 31 46573715
Cholelithiasis 11.51 9.74 143 112173 38538 46535208
Urinary incontinence 11.49 9.74 112 112204 28418 46545328
False positive investigation result 11.46 9.74 10 112306 546 46573200
Pyelonephritis 11.45 9.74 12 112304 15345 46558401
Pericardial effusion 11.45 9.74 28 112288 25515 46548231
Erythema 11.42 9.74 259 112057 142561 46431185
Alanine aminotransferase decreased 11.39 9.74 10 112306 550 46573196
Aspartate aminotransferase decreased 11.38 9.74 10 112306 551 46573195
Cerebral haemorrhage 11.28 9.74 33 112283 28338 46545408
Caesarean section 11.27 9.74 14 112302 16589 46557157
Basal cell carcinoma 11.25 9.74 20 112296 20467 46553279
Delusion 11.22 9.74 55 112261 11133 46562613
Wandering pacemaker 11.22 9.74 3 112313 8 46573738
Disorientation 11.20 9.74 137 112179 36781 46536965
Pregnancy 11.20 9.74 31 112285 27106 46546640
Clonus 11.17 9.74 28 112288 4052 46569694
Small for dates baby 11.07 9.74 26 112290 3611 46570135
Road traffic accident 11.06 9.74 96 112220 23595 46550151
Acute myeloid leukaemia 11.03 9.74 13 112303 15765 46557981
Generalised oedema 11.03 9.74 11 112305 14388 46559358
Product packaging difficult to open 11.01 9.74 4 112312 36 46573710
Dysphagia 10.86 9.74 253 112063 77059 46496687
Body temperature decreased 10.77 9.74 62 112254 13347 46560399
Peritonitis 10.69 9.74 21 112295 20693 46553053
Drug eruption 10.69 9.74 22 112294 21307 46552439
Electrocardiogram T wave inversion 10.55 9.74 25 112291 3491 46570255
Product substitution issue 10.49 9.74 67 112249 14964 46558782
Autonomic nervous system imbalance 10.47 9.74 20 112296 2406 46571340
Economic problem 10.43 9.74 18 112298 2002 46571744
Tobacco user 10.40 9.74 11 112305 763 46572983
Foetal death 10.40 9.74 4 112312 8739 46565007
Incoherent 10.35 9.74 29 112287 4483 46569263
Dystonia 10.35 9.74 54 112262 11203 46562543
Anaphylactic reaction 10.33 9.74 80 112236 53032 46520714
Anoxia 10.32 9.74 7 112309 262 46573484
Accidental overdose 10.26 9.74 83 112233 19983 46553763
Epistaxis 10.23 9.74 102 112214 64203 46509543
Thyroglobulin increased 10.22 9.74 4 112312 45 46573701
Tuberculosis 10.21 9.74 6 112310 10259 46563487
Thrombosis 10.19 9.74 86 112230 55983 46517763
Helicobacter infection 10.15 9.74 8 112308 11728 46562018
Flat affect 10.13 9.74 14 112302 1284 46572462
Dyskinesia oesophageal 10.11 9.74 3 112313 13 46573733
Heterophoria 10.11 9.74 3 112313 13 46573733
Apraxia 10.09 9.74 16 112300 1659 46572087
Increased appetite 10.09 9.74 44 112272 8483 46565263
Impulsive behaviour 9.87 9.74 15 112301 1500 46572246
Apathy 9.77 9.74 39 112277 7229 46566517
Gastric ulcer 9.77 9.74 24 112292 21839 46551907

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Priapism 646.49 10.63 263 53892 4480 29893843
Completed suicide 606.10 10.63 819 53336 98673 29799650
Serotonin syndrome 488.33 10.63 338 53817 17553 29880770
Drug abuse 317.80 10.63 548 53607 81524 29816799
Toxicity to various agents 314.32 10.63 862 53293 176321 29722002
Sopor 163.19 10.63 145 54010 10846 29887477
Insomnia 136.91 10.63 425 53730 92911 29805412
Suicidal ideation 136.69 10.63 239 53916 35875 29862448
Overdose 128.31 10.63 389 53766 83948 29814375
Depression 124.57 10.63 403 53752 90034 29808289
Anxiety 116.19 10.63 392 53763 89479 29808844
Respiratory arrest 111.18 10.63 194 53961 29064 29869259
Intentional overdose 102.96 10.63 230 53925 41251 29857072
Agitation 97.27 10.63 265 53890 53808 29844515
Suicide attempt 96.20 10.63 208 53947 36489 29861834
Electrocardiogram QT prolonged 80.43 10.63 191 53964 35644 29862679
Febrile neutropenia 75.59 10.63 50 54105 106643 29791680
Cardio-respiratory arrest 74.90 10.63 251 53904 57055 29841268
Mental status changes 65.93 10.63 181 53974 36898 29861425
Ventricular tachyarrhythmia 63.66 10.63 23 54132 278 29898045
Thrombocytopenia 58.16 10.63 99 54056 136945 29761378
Anaemia 58.05 10.63 188 53967 207804 29690519
Drug withdrawal syndrome 57.38 10.63 117 54038 19692 29878631
Drug interaction 54.66 10.63 576 53579 198992 29699331
Tremor 53.14 10.63 273 53882 75090 29823233
Aggression 53.02 10.63 167 53988 36740 29861583
Tardive dyskinesia 51.06 10.63 54 54101 5003 29893320
Poisoning 50.60 10.63 81 54074 11301 29887022
Intentional product misuse 49.01 10.63 156 53999 34511 29863812
Confusional state 48.77 10.63 413 53742 134421 29763902
Renal impairment 45.54 10.63 51 54104 84133 29814190
Pyrexia 45.44 10.63 329 53826 294160 29604163
Interstitial lung disease 44.26 10.63 27 54128 60170 29838153
Somnolence 43.62 10.63 312 53843 96451 29801872
Intentional self-injury 41.67 10.63 82 54073 13450 29884873
Antidepressant drug level above therapeutic 40.10 10.63 14 54141 152 29898171
General physical health deterioration 39.85 10.63 75 54080 99869 29798454
Neutropenia 39.52 10.63 111 54044 128429 29769894
Anger 38.71 10.63 71 54084 11049 29887274
Hepatic function abnormal 38.22 10.63 14 54141 41931 29856392
Symptom masked 38.07 10.63 18 54137 445 29897878
Paranoia 37.96 10.63 67 54088 10121 29888202
Alcoholism 37.25 10.63 38 54117 3376 29894947
Renal failure 37.02 10.63 115 54040 128851 29769472
Cardiac arrest 36.00 10.63 289 53866 92561 29805762
Restlessness 35.95 10.63 106 54049 22493 29875830
Pancytopenia 35.54 10.63 62 54093 84990 29813333
Septic shock 34.98 10.63 38 54117 63569 29834754
Sedation 34.29 10.63 85 54070 16288 29882035
Irritability 32.82 10.63 104 54051 22946 29875377
Sleep disorder 32.64 10.63 108 54047 24371 29873952
Akathisia 31.88 10.63 46 54109 5858 29892465
Hyperreflexia 31.70 10.63 32 54123 2807 29895516
Analgesic drug level above therapeutic 31.37 10.63 13 54142 232 29898091
Parkinsonism 31.31 10.63 51 54104 7218 29891105
Accidental overdose 31.27 10.63 88 54067 18187 29880136
Psychotic disorder 29.65 10.63 96 54059 21419 29876904
Multiple organ dysfunction syndrome 29.61 10.63 43 54112 63444 29834879
Delusion of replacement 29.58 10.63 11 54144 145 29898178
Cardiac failure 29.52 10.63 67 54088 83351 29814972
Disease progression 29.21 10.63 63 54092 79811 29818512
Environmental exposure 29.05 10.63 13 54142 282 29898041
Nightmare 28.86 10.63 66 54089 12010 29886313
Painful erection 28.82 10.63 12 54143 217 29898106
Granulocytopenia 28.62 10.63 45 54110 6181 29892142
Delirium 28.48 10.63 147 54008 40484 29857839
Penis injury 27.94 10.63 12 54143 235 29898088
Hyperhidrosis 27.74 10.63 212 53943 66878 29831445
Bradyphrenia 27.73 10.63 35 54120 3922 29894401
Withdrawal syndrome 27.46 10.63 62 54093 11188 29887135
Bipolar disorder 27.42 10.63 34 54121 3742 29894581
Sepsis 27.40 10.63 154 54001 146241 29752082
Cytomegalovirus infection 27.08 10.63 5 54150 23669 29874654
Hallucination, visual 26.99 10.63 77 54078 16036 29882287
Delusion 26.98 10.63 64 54091 11925 29886398
Clonus 25.95 10.63 27 54128 2454 29895869
Atrial fibrillation 25.93 10.63 104 54051 108020 29790303
Nervousness 25.53 10.63 62 54093 11726 29886597
Dysphoria 25.44 10.63 25 54130 2123 29896200
Erectile dysfunction 25.15 10.63 81 54074 18021 29880302
Drug reaction with eosinophilia and systemic symptoms 25.13 10.63 10 54145 28478 29869845
Acute kidney injury 24.97 10.63 347 53808 273495 29624828
Compulsive sexual behaviour 24.57 10.63 11 54144 239 29898084
Neuroleptic malignant syndrome 24.56 10.63 75 54080 16220 29882103
Homicide 24.45 10.63 18 54137 1028 29897295
Sexual dysfunction 24.36 10.63 41 54114 5960 29892363
Platelet count decreased 24.26 10.63 104 54051 106025 29792298
Polymerase chain reaction 23.87 10.63 8 54147 76 29898247
Fall 23.74 10.63 461 53694 181411 29716912
Erection increased 23.42 10.63 14 54141 562 29897761
Urine amphetamine positive 23.38 10.63 6 54149 19 29898304
Persistent depressive disorder 23.37 10.63 11 54144 269 29898054
Pruritus genital 23.36 10.63 13 54142 455 29897868
Post-traumatic stress disorder 23.36 10.63 21 54134 1594 29896729
Initial insomnia 23.26 10.63 26 54129 2563 29895760
Hallucination 22.55 10.63 159 53996 48900 29849423
Malignant neoplasm progression 22.50 10.63 62 54093 72225 29826098
Dry mouth 22.20 10.63 91 54064 22759 29875564
Substance abuse 22.08 10.63 43 54112 6997 29891326
Dyspnoea 22.01 10.63 448 53707 332847 29565476
Depersonalisation/derealisation disorder 21.93 10.63 13 54142 514 29897809
Injection site reaction 21.63 10.63 55 54100 10705 29887618
Cholestasis 21.62 10.63 9 54146 24941 29873382
Thinking abnormal 21.18 10.63 36 54119 5275 29893048
Euphoric mood 21.11 10.63 32 54123 4258 29894065
Bone marrow failure 21.01 10.63 14 54141 29771 29868552
Cogwheel rigidity 20.99 10.63 17 54138 1119 29897204
Hallucination, auditory 20.68 10.63 51 54104 9738 29888585
Drug screen positive 20.46 10.63 32 54123 4375 29893948
Restless legs syndrome 20.38 10.63 41 54114 6831 29891492
Dementia 20.34 10.63 59 54096 12402 29885921
Poor feeding infant 20.17 10.63 11 54144 370 29897953
Poor quality sleep 20.06 10.63 42 54113 7199 29891124
Nicotine dependence 19.78 10.63 10 54145 287 29898036
Abnormal behaviour 19.57 10.63 95 54060 25528 29872795
Food aversion 19.47 10.63 10 54145 297 29898026
Mucosal inflammation 19.35 10.63 16 54139 30478 29867845
Drug dependence 19.28 10.63 83 54072 21212 29877111
Haemoglobin decreased 19.24 10.63 124 54031 113974 29784349
Catatonia 19.23 10.63 31 54124 4349 29893974
Muscle rigidity 19.14 10.63 51 54104 10210 29888113
Obsessive thoughts 19.05 10.63 13 54142 658 29897665
Myotonia 18.92 10.63 6 54149 47 29898276
Psychomotor hyperactivity 18.61 10.63 44 54111 8180 29890143
Illness anxiety disorder 18.29 10.63 8 54147 164 29898159
Acute myeloid leukaemia 18.20 10.63 5 54150 18001 29880322
Lung disorder 18.20 10.63 18 54137 31451 29866872
Infection 18.14 10.63 76 54079 77998 29820325
Congenital pneumonia 18.13 10.63 7 54148 103 29898220
Hepatic failure 17.98 10.63 21 54134 34022 29864301
Hepatocellular injury 17.93 10.63 12 54143 25459 29872864
Drug resistance 17.87 10.63 7 54148 20126 29878197
C-reactive protein increased 17.86 10.63 32 54123 43441 29854882
Rash maculo-papular 17.85 10.63 12 54143 25406 29872917
Substance use disorder 17.82 10.63 7 54148 108 29898215
Penile haemorrhage 17.69 10.63 12 54143 601 29897722
Hangover 17.56 10.63 15 54140 1063 29897260
Depressed mood 17.48 10.63 69 54086 16960 29881363
Ascites 17.07 10.63 24 54131 35897 29862426
Procedural failure 17.03 10.63 6 54149 67 29898256
Lethargy 16.95 10.63 126 54029 39393 29858930
Generalised anxiety disorder 16.86 10.63 12 54143 650 29897673
Sleep-related eating disorder 16.82 10.63 9 54146 291 29898032
Blood cholinesterase decreased 16.74 10.63 7 54148 128 29898195
Myocardial infarction 16.67 10.63 146 54009 125479 29772844
Personality disorder 16.67 10.63 15 54140 1140 29897183
Respiratory failure 16.65 10.63 110 54045 100532 29797791
Exposure via ingestion 16.58 10.63 22 54133 2589 29895734
Sleep deficit 16.39 10.63 10 54145 417 29897906
Brain injury 16.33 10.63 33 54122 5515 29892808
Neck pain 16.25 10.63 78 54077 20866 29877457
Cough 16.24 10.63 147 54008 125495 29772828
Myoclonus 16.22 10.63 57 54098 13255 29885068
Pre-existing condition improved 16.13 10.63 19 54136 1982 29896341
Rash 16.11 10.63 247 53908 191642 29706681
Homicidal ideation 16.03 10.63 21 54134 2442 29895881
Bite 16.01 10.63 5 54150 37 29898286
Amputation of penis 15.95 10.63 3 54152 0 29898323
Blood bilirubin increased 15.94 10.63 26 54129 36610 29861713
Stress at work 15.89 10.63 7 54148 146 29898177
Abnormal dreams 15.81 10.63 41 54114 8074 29890249
Product administered at inappropriate site 15.70 10.63 17 54138 1618 29896705
Hostility 15.66 10.63 13 54142 886 29897437
Economic problem 15.50 10.63 16 54139 1441 29896882
Weight increased 15.45 10.63 205 53950 74708 29823615
Obsessive-compulsive disorder 15.12 10.63 27 54128 4114 29894209
Disorientation 15.12 10.63 103 54052 31315 29867008
Pneumocystis jirovecii pneumonia 15.12 10.63 6 54149 17114 29881209
Blood creatinine increased 15.04 10.63 100 54055 91275 29807048
Intestinal obstruction 15.00 10.63 8 54147 19204 29879119
Drug tolerance 14.95 10.63 19 54136 2143 29896180
Penile vein thrombosis 14.67 10.63 4 54151 17 29898306
Lower respiratory tract infection 14.63 10.63 16 54139 26698 29871625
Dyskinesia 14.61 10.63 78 54077 21756 29876567
Bruxism 14.60 10.63 15 54140 1344 29896979
Homeless 14.48 10.63 4 54151 18 29898305
Periorbital haemorrhage 14.33 10.63 6 54149 110 29898213
C-reactive protein 14.23 10.63 6 54149 112 29898211
Self-injurious ideation 14.19 10.63 16 54139 1593 29896730
Jaundice 14.18 10.63 23 54132 32463 29865860
Shock 14.18 10.63 80 54075 22779 29875544
Dysarthria 14.11 10.63 99 54056 30391 29867932
Extrapyramidal disorder 14.09 10.63 47 54108 10646 29887677
Hanging 14.09 10.63 6 54149 115 29898208
Flat affect 14.07 10.63 12 54143 849 29897474
Hypertonia 14.02 10.63 27 54128 4358 29893965
Foaming at mouth 14.01 10.63 11 54144 692 29897631
Product dose omission issue 13.94 10.63 238 53917 91393 29806930
Sleep sex 13.88 10.63 3 54152 3 29898320
Peritonitis 13.83 10.63 11 54144 21364 29876959
White blood cell count decreased 13.75 10.63 92 54063 83855 29814468
Disseminated intravascular coagulation 13.62 10.63 12 54143 22159 29876164
Eosinophilia 13.61 10.63 12 54143 22148 29876175
Cardiac failure congestive 13.58 10.63 93 54062 84314 29814009
Unresponsive to stimuli 13.55 10.63 88 54067 26331 29871992
Memory impairment 13.46 10.63 114 54041 37060 29861263
Diabetic foetopathy 13.30 10.63 7 54148 219 29898104
Urine leukocyte esterase positive 13.23 10.63 8 54147 328 29897995
Bronchopulmonary aspergillosis 13.21 10.63 3 54152 12281 29886042
Penile necrosis 13.17 10.63 5 54150 70 29898253
Erythema 13.13 10.63 84 54071 77367 29820956
Panic attack 13.12 10.63 40 54115 8641 29889682
Toxicologic test abnormal 13.11 10.63 10 54145 603 29897720
Alcohol use 13.10 10.63 24 54131 3731 29894592
Amnesia 13.08 10.63 82 54073 24239 29874084
Alcohol poisoning 13.06 10.63 24 54131 3740 29894583
Myelodysplastic syndrome 13.01 10.63 9 54146 18769 29879554
Reduced facial expression 13.01 10.63 11 54144 769 29897554
Dizziness 13.00 10.63 452 53703 194457 29703866
Ephelides 12.98 10.63 5 54150 73 29898250
Withdrawal catatonia 12.98 10.63 5 54150 73 29898250
Osteonecrosis of jaw 12.80 10.63 9 54146 18609 29879714
Drug abuser 12.75 10.63 26 54129 4375 29893948
Paedophilia 12.67 10.63 3 54152 6 29898317
Delirium febrile 12.65 10.63 4 54151 31 29898292
Wrong patient received product 12.62 10.63 16 54139 1801 29896522
General symptom 12.46 10.63 11 54144 815 29897508
Alanine aminotransferase increased 12.37 10.63 81 54074 74195 29824128
Pneumonia 12.36 10.63 487 53668 333819 29564504
Obsessive rumination 12.35 10.63 3 54152 7 29898316
Libido increased 12.26 10.63 11 54144 833 29897490
Pleural effusion 12.22 10.63 81 54074 73985 29824338
Discoloured vomit 12.14 10.63 8 54147 382 29897941
Psychomotor retardation 12.07 10.63 18 54137 2361 29895962
Vascular encephalopathy 12.03 10.63 5 54150 90 29898233
Heat stroke 11.97 10.63 11 54144 859 29897464
Major depression 11.93 10.63 24 54131 3998 29894325
Toxic epidermal necrolysis 11.90 10.63 9 54146 17931 29880392
Palmar-plantar erythrodysaesthesia syndrome 11.89 10.63 6 54149 14864 29883459
Pruritus 11.75 10.63 147 54008 118057 29780266
Terminal insomnia 11.68 10.63 8 54147 407 29897916
Product reconstitution quality issue 11.59 10.63 5 54150 99 29898224
Feeling abnormal 11.57 10.63 155 54000 56601 29841722
Thyroiditis acute 11.32 10.63 5 54150 105 29898218
Foetal exposure during pregnancy 11.19 10.63 32 54123 36839 29861484
Feelings of worthlessness 11.08 10.63 6 54149 199 29898124
Gambling disorder 10.92 10.63 15 54140 1825 29896498
Sinus bradycardia 10.90 10.63 46 54109 11649 29886674
Ejaculation failure 10.80 10.63 10 54145 788 29897535
Alcohol withdrawal syndrome 10.76 10.63 14 54141 1617 29896706
Drug withdrawal syndrome neonatal 10.71 10.63 20 54135 3155 29895168
Device related infection 10.71 10.63 9 54146 17006 29881317
Colitis 10.69 10.63 25 54130 30795 29867528
Bipolar I disorder 10.69 10.63 10 54145 799 29897524

Pharmacologic Action:

SourceCodeDescription
ATC N06AX05 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Other antidepressants
FDA EPC N0000175696 Serotonin Reuptake Inhibitor
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D000928 Antidepressive Agents
MeSH PA D018687 Antidepressive Agents, Second-Generation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D017367 Serotonin Uptake Inhibitors
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:35469 thymoanaleptics
CHEBI has role CHEBI:35474 minor tranquilisers
CHEBI has role CHEBI:35717 sedatives
CHEBI has role CHEBI:37887 adrenergic receptor blockaders
CHEBI has role CHEBI:37955 h1-receptor blockers
CHEBI has role CHEBI:50949 serotonin reuptake inhibitor

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Major depressive disorder indication 370143000
Insomnia off-label use 193462001
Priapism contraindication 6273006 DOID:9286
Suicidal thoughts contraindication 6471006
Orthostatic hypotension contraindication 28651003
Torsades de pointes contraindication 31722008
Hypokalemia contraindication 43339004
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Heart disease contraindication 56265001 DOID:114
Blood coagulation disorder contraindication 64779008 DOID:1247
Prolonged QT interval contraindication 111975006
Hypomagnesemia contraindication 190855004
Benign prostatic hyperplasia contraindication 266569009
Myocardial infarction in recovery phase contraindication 418044006
Congenital long QT syndrome contraindication 442917000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST Ki 6.65 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 7.35 WOMBAT-PK CHEMBL
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 6.80 WOMBAT-PK CHEMBL
Alpha-2C adrenergic receptor GPCR Ki 6.81 PDSP
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.03 DRUG MATRIX
Alpha-2B adrenergic receptor GPCR Ki 6.75 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 5.90 DRUG MATRIX
Alpha-1D adrenergic receptor GPCR Ki 7.33 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Kd 5.13 WOMBAT-PK
Histamine H1 receptor GPCR Ki 6.21 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR IC50 9.55 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 7.08 WOMBAT-PK
5-hydroxytryptamine receptor 1A GPCR Ki 7.02 WOMBAT-PK
Sodium-dependent noradrenaline transporter Transporter Kd 5.07 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.54 WOMBAT-PK
Alpha-2A adrenergic receptor GPCR Ki 6.58 WOMBAT-PK
D(4) dopamine receptor GPCR Ki 6.15 PDSP
5-hydroxytryptamine receptor 7 GPCR Ki 5.75 PDSP
D(2) dopamine receptor GPCR Ki 5.46 PDSP
D(1A) dopamine receptor GPCR Ki 5.43 PDSP
5-hydroxytryptamine receptor 1D GPCR Ki 6.97 PDSP
Histamine H2 receptor GPCR Ki 5.48 PDSP
Alpha-1B adrenergic receptor GPCR Ki 7.21 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 6.08 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 6.08 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR IC50 7.77 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 6.65 CHEMBL
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST Ki 6.70 IUPHAR
Alpha-1A adrenergic receptor GPCR IC50 6.93 CHEMBL

External reference:

IDSource
4019954 VUID
N0000148039 NUI
D00820 KEGG_DRUG
25332-39-2 SECONDARY_CAS_RN
4018812 VANDF
4019954 VANDF
C0040805 UMLSCUI
CHEBI:9654 CHEBI
CHEMBL621 ChEMBL_ID
CHEMBL1200798 ChEMBL_ID
D014196 MESH_DESCRIPTOR_UI
2878 INN_ID
DB00656 DRUGBANK_ID
YBK48BXK30 UNII
5533 PUBCHEM_CID
213 IUPHAR_LIGAND_ID
10737 RXNORM
1504 MMSL
5609 MMSL
d00395 MMSL
001511 NDDF
004610 NDDF
372829000 SNOMEDCT_US
58956008 SNOMEDCT_US
7336002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0555-0733 TABLET 300 mg ORAL ANDA 26 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0603-6160 TABLET, FILM COATED 50 mg ORAL ANDA 29 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0603-6161 TABLET, FILM COATED 100 mg ORAL ANDA 29 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-2578 TABLET 50 mg ORAL ANDA 31 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-2579 TABLET 100 mg ORAL ANDA 31 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8155 TABLET 150 mg ORAL ANDA 30 sections
TRAZODONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8339 TABLET 150 mg ORAL ANDA 31 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8371 TABLET 50 mg ORAL ANDA 30 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8386 TABLET 100 mg ORAL ANDA 30 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6554 TABLET 50 mg ORAL ANDA 21 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6555 TABLET 100 mg ORAL ANDA 21 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6868 TABLET 50 mg ORAL ANDA 27 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6869 TABLET 100 mg ORAL ANDA 27 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-532 TABLET 100 mg ORAL ANDA 31 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-533 TABLET 150 mg ORAL ANDA 24 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-534 TABLET 50 mg ORAL ANDA 30 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-867 TABLET 150 mg ORAL ANDA 21 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 12634-193 TABLET, FILM COATED 50 mg ORAL ANDA 31 sections
Trazodone Hydrochloride Human Prescription Drug Label 1 13107-079 TABLET 50 mg ORAL ANDA 29 sections
Trazodone Hydrochloride Human Prescription Drug Label 1 13107-080 TABLET 100 mg ORAL ANDA 29 sections
Trazodone Hydrochloride Human Prescription Drug Label 1 13107-081 TABLET 150 mg ORAL ANDA 29 sections
Trazodone Hydrochloride Human Prescription Drug Label 1 13107-082 TABLET 300 mg ORAL ANDA 29 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-330 TABLET 50 mg ORAL ANDA 22 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-331 TABLET 100 mg ORAL ANDA 22 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-332 TABLET 150 mg ORAL ANDA 22 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-333 TABLET 300 mg ORAL ANDA 22 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 16590-231 TABLET 50 mg ORAL ANDA 25 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 16590-232 TABLET 100 mg ORAL ANDA 25 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 16590-585 TABLET 150 mg ORAL ANDA 25 sections
Trazodone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 16729-299 TABLET 50 mg ORAL ANDA 20 sections