Stem definition | Drug id | CAS RN |
---|---|---|
2717 | 19794-93-5 |
Dose | Unit | Route |
---|---|---|
0.30 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.20 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 23.05 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 81 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.52 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 1.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.08 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 7.30 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 24, 1981 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1266.84 | 9.74 | 1653 | 110663 | 144267 | 46429479 |
Drug abuse | 517.36 | 9.74 | 698 | 111618 | 62710 | 46511036 |
Toxicity to various agents | 421.60 | 9.74 | 1291 | 111025 | 210475 | 46363271 |
Serotonin syndrome | 356.08 | 9.74 | 361 | 111955 | 23859 | 46549887 |
Sopor | 314.47 | 9.74 | 308 | 112008 | 19520 | 46554226 |
Respiratory arrest | 232.21 | 9.74 | 343 | 111973 | 33473 | 46540273 |
Suicidal ideation | 194.11 | 9.74 | 423 | 111893 | 55959 | 46517787 |
Cardio-respiratory arrest | 185.81 | 9.74 | 431 | 111885 | 59438 | 46514308 |
Depression | 171.24 | 9.74 | 836 | 111480 | 169268 | 46404478 |
Suicide attempt | 155.44 | 9.74 | 382 | 111934 | 54654 | 46519092 |
Overdose | 154.63 | 9.74 | 568 | 111748 | 101411 | 46472335 |
Poisoning | 124.69 | 9.74 | 161 | 112155 | 13833 | 46559913 |
Rheumatoid arthritis | 118.06 | 9.74 | 251 | 112065 | 239964 | 46333782 |
Insomnia | 115.42 | 9.74 | 735 | 111581 | 164189 | 46409557 |
Cardiac arrest | 113.85 | 9.74 | 475 | 111841 | 89924 | 46483822 |
Presbyacusis | 97.80 | 9.74 | 69 | 112247 | 2753 | 46570993 |
Maternal exposure during pregnancy | 92.52 | 9.74 | 67 | 112249 | 102482 | 46471264 |
Pleural thickening | 88.89 | 9.74 | 63 | 112253 | 2532 | 46571214 |
Pleural fibrosis | 87.59 | 9.74 | 71 | 112245 | 3498 | 46570248 |
Hypomania | 86.58 | 9.74 | 77 | 112239 | 4311 | 46569435 |
Anxiety | 85.61 | 9.74 | 738 | 111578 | 181219 | 46392527 |
Neutropenia | 84.18 | 9.74 | 134 | 112182 | 143070 | 46430676 |
Agitation | 83.37 | 9.74 | 308 | 112008 | 55107 | 46518639 |
Blood magnesium increased | 82.40 | 9.74 | 64 | 112252 | 2963 | 46570783 |
Electrocardiogram QT prolonged | 81.21 | 9.74 | 290 | 112026 | 51035 | 46522711 |
Drug withdrawal syndrome | 78.26 | 9.74 | 191 | 112125 | 27193 | 46546553 |
Irritability | 77.57 | 9.74 | 197 | 112119 | 28749 | 46544997 |
Tremor | 72.73 | 9.74 | 502 | 111814 | 115137 | 46458609 |
Deafness neurosensory | 71.58 | 9.74 | 70 | 112246 | 4424 | 46569322 |
Exposure during pregnancy | 67.69 | 9.74 | 97 | 112219 | 108115 | 46465631 |
Anaemia | 65.38 | 9.74 | 355 | 111961 | 255424 | 46318322 |
Thrombocytopenia | 64.86 | 9.74 | 129 | 112187 | 126452 | 46447294 |
Withdrawal syndrome | 64.59 | 9.74 | 138 | 112178 | 17996 | 46555750 |
Febrile neutropenia | 63.04 | 9.74 | 81 | 112235 | 94546 | 46479200 |
Psychotic disorder | 59.62 | 9.74 | 153 | 112163 | 22468 | 46551278 |
Schizophrenia | 58.91 | 9.74 | 87 | 112229 | 8481 | 46565265 |
Epigastric discomfort | 58.00 | 9.74 | 70 | 112246 | 5614 | 46568132 |
Myocardial stunning | 57.64 | 9.74 | 20 | 112296 | 155 | 46573591 |
Hand deformity | 56.47 | 9.74 | 8 | 112308 | 34566 | 46539180 |
Systemic lupus erythematosus | 55.69 | 9.74 | 45 | 112271 | 65135 | 46508611 |
Malignant neoplasm progression | 55.25 | 9.74 | 45 | 112271 | 64881 | 46508865 |
Synovitis | 54.94 | 9.74 | 40 | 112276 | 61035 | 46512711 |
Tardive dyskinesia | 53.90 | 9.74 | 78 | 112238 | 7465 | 46566281 |
Intentional overdose | 53.36 | 9.74 | 302 | 112014 | 64642 | 46509104 |
Mucosal inflammation | 53.17 | 9.74 | 14 | 112302 | 38962 | 46534784 |
Joint swelling | 52.08 | 9.74 | 214 | 112102 | 165859 | 46407887 |
Sedation | 51.38 | 9.74 | 146 | 112170 | 22764 | 46550982 |
Contraindicated product administered | 50.64 | 9.74 | 71 | 112245 | 79876 | 46493870 |
General physical health deterioration | 50.33 | 9.74 | 129 | 112187 | 115640 | 46458106 |
Infusion related reaction | 50.26 | 9.74 | 105 | 112211 | 101103 | 46472643 |
Drug screen positive | 48.26 | 9.74 | 53 | 112263 | 3838 | 46569908 |
Jaundice cholestatic | 48.18 | 9.74 | 60 | 112256 | 4969 | 46568777 |
Drug intolerance | 47.04 | 9.74 | 188 | 112128 | 146861 | 46426885 |
Drug interaction | 46.44 | 9.74 | 716 | 111600 | 202378 | 46371368 |
Migraine | 46.39 | 9.74 | 308 | 112008 | 69718 | 46504028 |
Pyrexia | 45.96 | 9.74 | 578 | 111738 | 348224 | 46225522 |
Rash | 45.05 | 9.74 | 596 | 111720 | 355916 | 46217830 |
Haemoglobin decreased | 45.05 | 9.74 | 159 | 112157 | 128790 | 46444956 |
Depressed level of consciousness | 44.35 | 9.74 | 229 | 112087 | 47340 | 46526406 |
Akathisia | 44.19 | 9.74 | 72 | 112244 | 7642 | 46566104 |
Pancytopenia | 44.14 | 9.74 | 86 | 112230 | 84972 | 46488774 |
Bone marrow failure | 43.76 | 9.74 | 9 | 112307 | 29660 | 46544086 |
Hyperreflexia | 43.02 | 9.74 | 58 | 112258 | 5196 | 46568550 |
Visual perseveration | 42.79 | 9.74 | 13 | 112303 | 62 | 46573684 |
Nightmare | 42.44 | 9.74 | 111 | 112205 | 16487 | 46557259 |
Acute kidney injury | 41.56 | 9.74 | 365 | 111951 | 235490 | 46338256 |
Asphyxia | 40.90 | 9.74 | 57 | 112259 | 5269 | 46568477 |
Cardiac failure | 40.48 | 9.74 | 82 | 112234 | 79866 | 46493880 |
Bone cyst | 40.48 | 9.74 | 36 | 112280 | 2015 | 46571731 |
Sleep disorder | 40.03 | 9.74 | 220 | 112096 | 46575 | 46527171 |
Anger | 39.70 | 9.74 | 88 | 112228 | 11764 | 46561982 |
Accidental poisoning | 39.20 | 9.74 | 22 | 112294 | 583 | 46573163 |
Osteopenia | 38.92 | 9.74 | 109 | 112207 | 16852 | 46556894 |
Swelling | 38.67 | 9.74 | 161 | 112155 | 124350 | 46449396 |
Memory impairment | 38.05 | 9.74 | 317 | 111999 | 77020 | 46496726 |
Multiple sclerosis relapse | 38.03 | 9.74 | 201 | 112115 | 41924 | 46531822 |
Muscle rigidity | 38.03 | 9.74 | 78 | 112238 | 9883 | 46563863 |
Suspected suicide | 37.47 | 9.74 | 51 | 112265 | 4610 | 46569136 |
Treatment failure | 37.24 | 9.74 | 108 | 112208 | 92979 | 46480767 |
Adjustment disorder with mixed anxiety and depressed mood | 36.93 | 9.74 | 12 | 112304 | 74 | 46573672 |
Intentional self-injury | 36.90 | 9.74 | 135 | 112181 | 24031 | 46549715 |
Abnormal behaviour | 36.79 | 9.74 | 123 | 112193 | 20935 | 46552811 |
Leukopenia | 35.55 | 9.74 | 69 | 112247 | 68274 | 46505472 |
Cyst | 35.21 | 9.74 | 85 | 112231 | 12015 | 46561731 |
Torsade de pointes | 34.96 | 9.74 | 85 | 112231 | 12069 | 46561677 |
Mental disorder | 34.85 | 9.74 | 126 | 112190 | 22299 | 46551447 |
Pleurothotonus | 34.72 | 9.74 | 26 | 112290 | 1139 | 46572607 |
Somatic delusion | 33.62 | 9.74 | 20 | 112296 | 593 | 46573153 |
Sepsis | 33.48 | 9.74 | 191 | 112125 | 135823 | 46437923 |
Platelet count decreased | 33.17 | 9.74 | 126 | 112190 | 99898 | 46473848 |
Polycystic ovaries | 32.84 | 9.74 | 27 | 112289 | 1357 | 46572389 |
Oral discomfort | 32.62 | 9.74 | 64 | 112252 | 7854 | 46565892 |
Toxic epidermal necrolysis | 32.36 | 9.74 | 7 | 112309 | 22271 | 46551475 |
Injection site mass | 31.94 | 9.74 | 94 | 112222 | 14946 | 46558800 |
Affective disorder | 31.83 | 9.74 | 48 | 112268 | 4767 | 46568979 |
Intentional product misuse | 31.63 | 9.74 | 208 | 112108 | 46920 | 46526826 |
Priapism | 31.47 | 9.74 | 7 | 112309 | 5 | 46573741 |
Arteriosclerosis coronary artery | 31.30 | 9.74 | 64 | 112252 | 8092 | 46565654 |
Cholestasis | 30.85 | 9.74 | 13 | 112303 | 26880 | 46546866 |
Osteosclerosis | 30.61 | 9.74 | 40 | 112276 | 3476 | 46570270 |
Blood prolactin increased | 30.43 | 9.74 | 37 | 112279 | 2990 | 46570756 |
Dyskinesia | 30.33 | 9.74 | 144 | 112172 | 28781 | 46544965 |
Pericarditis | 30.07 | 9.74 | 10 | 112306 | 23917 | 46549829 |
Confusional state | 30.02 | 9.74 | 546 | 111770 | 159346 | 46414400 |
C-reactive protein increased | 29.74 | 9.74 | 60 | 112256 | 58530 | 46515216 |
Confabulation | 29.64 | 9.74 | 14 | 112302 | 256 | 46573490 |
Hereditary angioedema | 29.60 | 9.74 | 50 | 112266 | 5466 | 46568280 |
Blood potassium increased | 29.55 | 9.74 | 99 | 112217 | 16868 | 46556878 |
Dissociation | 29.45 | 9.74 | 29 | 112287 | 1848 | 46571898 |
Unresponsive to stimuli | 29.37 | 9.74 | 154 | 112162 | 32020 | 46541726 |
Bradyphrenia | 28.94 | 9.74 | 53 | 112263 | 6177 | 46567569 |
Mental status changes | 28.61 | 9.74 | 173 | 112143 | 37915 | 46535831 |
Psychomotor hyperactivity | 28.48 | 9.74 | 68 | 112248 | 9545 | 46564201 |
Hepatocellular injury | 28.33 | 9.74 | 18 | 112298 | 29504 | 46544242 |
Mood altered | 28.30 | 9.74 | 82 | 112234 | 12925 | 46560821 |
Substance abuse | 28.20 | 9.74 | 42 | 112274 | 4125 | 46569621 |
Cytomegalovirus infection | 27.82 | 9.74 | 5 | 112311 | 18139 | 46555607 |
Weight increased | 27.24 | 9.74 | 551 | 111765 | 163922 | 46409824 |
Wound | 27.11 | 9.74 | 38 | 112278 | 42764 | 46530982 |
Abnormal dreams | 26.54 | 9.74 | 69 | 112247 | 10210 | 46563536 |
Accidental death | 26.31 | 9.74 | 27 | 112289 | 1808 | 46571938 |
Pneumocystis jirovecii pneumonia | 26.18 | 9.74 | 3 | 112313 | 15245 | 46558501 |
Tachyphrenia | 26.11 | 9.74 | 23 | 112293 | 1271 | 46572475 |
Disease progression | 25.95 | 9.74 | 122 | 112194 | 91178 | 46482568 |
Balance disorder | 25.86 | 9.74 | 253 | 112063 | 64268 | 46509478 |
Premature baby | 25.68 | 9.74 | 6 | 112310 | 18106 | 46555640 |
Hyperkalaemia | 25.67 | 9.74 | 52 | 112264 | 50657 | 46523089 |
Tearfulness | 25.61 | 9.74 | 40 | 112276 | 4095 | 46569651 |
Pleural effusion | 25.29 | 9.74 | 108 | 112208 | 82844 | 46490902 |
Skin lesion | 25.17 | 9.74 | 129 | 112187 | 26584 | 46547162 |
Peripheral swelling | 25.08 | 9.74 | 251 | 112065 | 157820 | 46415926 |
Bipolar disorder | 24.85 | 9.74 | 54 | 112262 | 7123 | 46566623 |
Device expulsion | 24.81 | 9.74 | 18 | 112298 | 27524 | 46546222 |
Premature delivery | 24.79 | 9.74 | 11 | 112305 | 22058 | 46551688 |
Exostosis | 24.58 | 9.74 | 67 | 112249 | 10196 | 46563550 |
Multiple organ dysfunction syndrome | 24.53 | 9.74 | 55 | 112261 | 51655 | 46522091 |
Neuroleptic malignant syndrome | 24.08 | 9.74 | 70 | 112246 | 11052 | 46562694 |
Septic shock | 24.01 | 9.74 | 66 | 112250 | 57827 | 46515919 |
Plasma cell myeloma | 23.92 | 9.74 | 44 | 112272 | 44434 | 46529312 |
Major depression | 23.92 | 9.74 | 51 | 112265 | 6639 | 46567107 |
Aggression | 23.68 | 9.74 | 113 | 112203 | 22631 | 46551115 |
Fibromyalgia | 23.31 | 9.74 | 159 | 112157 | 36304 | 46537442 |
Drug reaction with eosinophilia and systemic symptoms | 23.29 | 9.74 | 22 | 112294 | 29526 | 46544220 |
Rheumatoid factor positive | 23.29 | 9.74 | 10 | 112306 | 20451 | 46553295 |
Somnolence | 23.20 | 9.74 | 516 | 111800 | 156005 | 46417741 |
Hostility | 23.17 | 9.74 | 22 | 112294 | 1340 | 46572406 |
Cardiac failure congestive | 23.02 | 9.74 | 128 | 112188 | 91622 | 46482124 |
Depressed mood | 22.93 | 9.74 | 148 | 112168 | 33171 | 46540575 |
Depressive symptom | 22.75 | 9.74 | 31 | 112285 | 2805 | 46570941 |
Product dose omission issue | 22.65 | 9.74 | 548 | 111768 | 167972 | 46405774 |
Stevens-Johnson syndrome | 22.64 | 9.74 | 14 | 112302 | 23283 | 46550463 |
Hallucination, auditory | 22.63 | 9.74 | 67 | 112249 | 10689 | 46563057 |
Alopecia | 22.52 | 9.74 | 266 | 112050 | 162148 | 46411598 |
Hepatic function abnormal | 22.36 | 9.74 | 30 | 112286 | 34391 | 46539355 |
Drug dependence | 22.28 | 9.74 | 101 | 112215 | 19800 | 46553946 |
Exposure via ingestion | 22.12 | 9.74 | 34 | 112282 | 3433 | 46570313 |
Alcoholism | 22.12 | 9.74 | 27 | 112289 | 2191 | 46571555 |
Wound infection fungal | 21.72 | 9.74 | 8 | 112308 | 75 | 46573671 |
Sensation of foreign body | 21.72 | 9.74 | 36 | 112280 | 3875 | 46569871 |
Dry eye | 21.68 | 9.74 | 136 | 112180 | 30186 | 46543560 |
Muscle twitching | 21.59 | 9.74 | 81 | 112235 | 14591 | 46559155 |
Solar urticaria | 21.57 | 9.74 | 7 | 112309 | 43 | 46573703 |
Abdominal discomfort | 21.57 | 9.74 | 246 | 112070 | 150919 | 46422827 |
Galactorrhoea | 21.15 | 9.74 | 35 | 112281 | 3762 | 46569984 |
Apallic syndrome | 21.05 | 9.74 | 15 | 112301 | 608 | 46573138 |
Perseveration | 21.05 | 9.74 | 11 | 112305 | 252 | 46573494 |
Off label use | 20.71 | 9.74 | 727 | 111589 | 379114 | 46194632 |
Interstitial lung disease | 20.56 | 9.74 | 64 | 112252 | 53885 | 46519861 |
Meningitis streptococcal | 20.43 | 9.74 | 9 | 112307 | 139 | 46573607 |
Glossodynia | 20.40 | 9.74 | 48 | 112268 | 44325 | 46529421 |
Abortion spontaneous | 20.24 | 9.74 | 47 | 112269 | 43599 | 46530147 |
Hyper IgE syndrome | 19.79 | 9.74 | 10 | 112306 | 213 | 46573533 |
Myoclonus | 19.29 | 9.74 | 77 | 112239 | 14275 | 46559471 |
Vasoplegia syndrome | 19.27 | 9.74 | 18 | 112298 | 1074 | 46572672 |
Poor quality sleep | 19.05 | 9.74 | 80 | 112236 | 15173 | 46558573 |
Lung disorder | 19.00 | 9.74 | 48 | 112268 | 43256 | 46530490 |
Atrial fibrillation | 18.79 | 9.74 | 159 | 112157 | 103431 | 46470315 |
Plasma cell mastitis | 18.79 | 9.74 | 5 | 112311 | 13 | 46573733 |
Fall | 18.45 | 9.74 | 968 | 111348 | 328129 | 46245617 |
Periorbital swelling | 18.43 | 9.74 | 19 | 112297 | 1279 | 46572467 |
Post-traumatic stress disorder | 18.25 | 9.74 | 34 | 112282 | 4014 | 46569732 |
Oppositional defiant disorder | 18.07 | 9.74 | 6 | 112310 | 40 | 46573706 |
Sleep apnoea syndrome | 18.06 | 9.74 | 103 | 112213 | 22098 | 46551648 |
Lower respiratory tract infection | 17.87 | 9.74 | 70 | 112246 | 55019 | 46518727 |
Compartment syndrome | 17.81 | 9.74 | 23 | 112293 | 1976 | 46571770 |
Neutrophil count decreased | 17.64 | 9.74 | 50 | 112266 | 43376 | 46530370 |
Body tinea | 17.64 | 9.74 | 16 | 112300 | 919 | 46572827 |
Dysphoria | 17.59 | 9.74 | 36 | 112280 | 4553 | 46569193 |
Marchiafava-Bignami disease | 17.58 | 9.74 | 5 | 112311 | 18 | 46573728 |
Purple glove syndrome | 17.55 | 9.74 | 9 | 112307 | 198 | 46573548 |
Nervousness | 17.51 | 9.74 | 123 | 112193 | 28352 | 46545394 |
Restless legs syndrome | 17.44 | 9.74 | 80 | 112236 | 15763 | 46557983 |
Metastases to liver | 17.38 | 9.74 | 13 | 112303 | 19572 | 46554174 |
Sense of a foreshortened future | 17.37 | 9.74 | 4 | 112312 | 4 | 46573742 |
Screaming | 17.22 | 9.74 | 29 | 112287 | 3162 | 46570584 |
Alcohol withdrawal syndrome | 17.14 | 9.74 | 15 | 112301 | 822 | 46572924 |
Sinus bradycardia | 16.99 | 9.74 | 72 | 112244 | 13710 | 46560036 |
Red blood cell sedimentation rate increased | 16.95 | 9.74 | 18 | 112298 | 22871 | 46550875 |
Homicidal ideation | 16.47 | 9.74 | 21 | 112295 | 1781 | 46571965 |
Extrapyramidal disorder | 16.41 | 9.74 | 62 | 112254 | 11206 | 46562540 |
Product use issue | 16.40 | 9.74 | 147 | 112169 | 94497 | 46479249 |
Mood swings | 16.38 | 9.74 | 80 | 112236 | 16172 | 46557574 |
Tonic clonic movements | 16.36 | 9.74 | 17 | 112299 | 1155 | 46572591 |
Drug resistance | 16.11 | 9.74 | 11 | 112305 | 17357 | 46556389 |
Mania | 16.06 | 9.74 | 60 | 112256 | 10786 | 46562960 |
Heart rate abnormal | 15.97 | 9.74 | 29 | 112287 | 3358 | 46570388 |
Cognitive disorder | 15.95 | 9.74 | 147 | 112169 | 36736 | 46537010 |
Eczema eyelids | 15.95 | 9.74 | 7 | 112309 | 107 | 46573639 |
Toxic skin eruption | 15.88 | 9.74 | 5 | 112311 | 12382 | 46561364 |
Skin ulcer | 15.83 | 9.74 | 34 | 112282 | 32424 | 46541322 |
Ascites | 15.70 | 9.74 | 41 | 112275 | 36543 | 46537203 |
Neoplasm progression | 15.63 | 9.74 | 25 | 112291 | 26658 | 46547088 |
Restlessness | 15.54 | 9.74 | 110 | 112206 | 25414 | 46548332 |
Panic reaction | 15.42 | 9.74 | 30 | 112286 | 3659 | 46570087 |
Face oedema | 15.41 | 9.74 | 14 | 112302 | 19139 | 46554607 |
Renal failure | 15.37 | 9.74 | 187 | 112129 | 113407 | 46460339 |
Sensitisation | 15.30 | 9.74 | 13 | 112303 | 684 | 46573062 |
Crying | 15.22 | 9.74 | 95 | 112221 | 21046 | 46552700 |
Coma | 14.98 | 9.74 | 210 | 112106 | 58139 | 46515607 |
Anaphylactic shock | 14.95 | 9.74 | 16 | 112300 | 20258 | 46553488 |
Feeling of despair | 14.89 | 9.74 | 20 | 112296 | 1785 | 46571961 |
Angioedema | 14.76 | 9.74 | 47 | 112269 | 39295 | 46534451 |
Haemangioma congenital | 14.75 | 9.74 | 11 | 112305 | 479 | 46573267 |
Psychomotor skills impaired | 14.74 | 9.74 | 22 | 112294 | 2164 | 46571582 |
Disorganised speech | 14.69 | 9.74 | 14 | 112302 | 857 | 46572889 |
Rash maculo-papular | 14.61 | 9.74 | 28 | 112288 | 27846 | 46545900 |
Mitral valve thickening | 14.61 | 9.74 | 5 | 112311 | 37 | 46573709 |
Panic attack | 14.60 | 9.74 | 91 | 112225 | 20151 | 46553595 |
Speech disorder | 14.58 | 9.74 | 142 | 112174 | 36025 | 46537721 |
Obsessive-compulsive disorder | 14.49 | 9.74 | 27 | 112289 | 3188 | 46570558 |
Arthropathy | 14.48 | 9.74 | 132 | 112184 | 84568 | 46489178 |
Middle insomnia | 14.39 | 9.74 | 53 | 112263 | 9462 | 46564284 |
Herpes zoster | 14.27 | 9.74 | 100 | 112216 | 67772 | 46505974 |
Disturbance in attention | 14.27 | 9.74 | 127 | 112189 | 31433 | 46542313 |
Injection site necrosis | 14.27 | 9.74 | 17 | 112299 | 1345 | 46572401 |
Burning mouth syndrome | 14.19 | 9.74 | 10 | 112306 | 398 | 46573348 |
Type 2 diabetes mellitus | 14.12 | 9.74 | 89 | 112227 | 19786 | 46553960 |
Disseminated intravascular coagulation | 14.01 | 9.74 | 15 | 112301 | 18990 | 46554756 |
Lethargy | 13.89 | 9.74 | 186 | 112130 | 50985 | 46522761 |
Liver function test abnormal | 13.87 | 9.74 | 61 | 112255 | 46426 | 46527320 |
Oedema peripheral | 13.83 | 9.74 | 286 | 112030 | 159420 | 46414326 |
Chromaturia | 13.78 | 9.74 | 72 | 112244 | 14947 | 46558799 |
Morbid thoughts | 13.76 | 9.74 | 11 | 112305 | 531 | 46573215 |
Polyglandular autoimmune syndrome type II | 13.76 | 9.74 | 5 | 112311 | 45 | 46573701 |
Initial insomnia | 13.74 | 9.74 | 32 | 112284 | 4420 | 46569326 |
Spleen congestion | 13.73 | 9.74 | 7 | 112309 | 152 | 46573594 |
Decreased interest | 13.62 | 9.74 | 26 | 112290 | 3126 | 46570620 |
Therapeutic product effect decreased | 13.57 | 9.74 | 130 | 112186 | 82471 | 46491275 |
Myoglobin blood increased | 13.55 | 9.74 | 17 | 112299 | 1419 | 46572327 |
Skin texture abnormal | 13.52 | 9.74 | 9 | 112307 | 326 | 46573420 |
Aspiration | 13.51 | 9.74 | 52 | 112264 | 9479 | 46564267 |
Urticaria | 13.44 | 9.74 | 201 | 112115 | 117691 | 46456055 |
Gambling disorder | 13.29 | 9.74 | 16 | 112300 | 1280 | 46572466 |
Affect lability | 13.26 | 9.74 | 46 | 112270 | 7974 | 46565772 |
Tongue discolouration | 13.26 | 9.74 | 25 | 112291 | 2979 | 46570767 |
Granulocytopenia | 13.21 | 9.74 | 35 | 112281 | 5238 | 46568508 |
Coagulopathy | 13.20 | 9.74 | 15 | 112301 | 18484 | 46555262 |
Intervertebral disc degeneration | 13.19 | 9.74 | 65 | 112251 | 13187 | 46560559 |
Gastrointestinal haemorrhage | 13.04 | 9.74 | 121 | 112195 | 77252 | 46496494 |
Social avoidant behaviour | 12.99 | 9.74 | 24 | 112292 | 2815 | 46570931 |
Ejection fraction | 12.91 | 9.74 | 11 | 112305 | 581 | 46573165 |
Mydriasis | 12.91 | 9.74 | 55 | 112261 | 10498 | 46563248 |
Rash erythematous | 12.91 | 9.74 | 41 | 112275 | 34309 | 46539437 |
Feeling abnormal | 12.89 | 9.74 | 393 | 111923 | 124667 | 46449079 |
Paranoia | 12.79 | 9.74 | 55 | 112261 | 10542 | 46563204 |
Drug screen false positive | 12.75 | 9.74 | 13 | 112303 | 864 | 46572882 |
Cerebral infarction | 12.66 | 9.74 | 23 | 112293 | 23343 | 46550403 |
Slow speech | 12.63 | 9.74 | 16 | 112300 | 1348 | 46572398 |
Encephalopathy | 12.63 | 9.74 | 130 | 112186 | 33459 | 46540287 |
Self-injurious ideation | 12.54 | 9.74 | 21 | 112295 | 2279 | 46571467 |
Borderline personality disorder | 12.43 | 9.74 | 12 | 112304 | 746 | 46573000 |
Drug screen negative | 12.43 | 9.74 | 9 | 112307 | 374 | 46573372 |
Drug ineffective | 12.42 | 9.74 | 1435 | 110881 | 676403 | 45897343 |
Tracheitis | 12.38 | 9.74 | 12 | 112304 | 750 | 46572996 |
Deformity | 12.33 | 9.74 | 42 | 112274 | 7215 | 46566531 |
Stomatitis | 12.31 | 9.74 | 105 | 112211 | 68192 | 46505554 |
Liver disorder | 12.29 | 9.74 | 47 | 112269 | 37199 | 46536547 |
Osteonecrosis of jaw | 12.28 | 9.74 | 42 | 112274 | 34360 | 46539386 |
Medication error | 12.28 | 9.74 | 121 | 112195 | 30790 | 46542956 |
Personal relationship issue | 12.27 | 9.74 | 4 | 112312 | 25 | 46573721 |
Hyperhidrosis | 12.16 | 9.74 | 291 | 112025 | 89017 | 46484729 |
Palmar-plantar erythrodysaesthesia syndrome | 12.13 | 9.74 | 19 | 112297 | 20432 | 46553314 |
Transplant rejection | 12.08 | 9.74 | 4 | 112312 | 9592 | 46564154 |
Gastroenteritis radiation | 12.07 | 9.74 | 10 | 112306 | 508 | 46573238 |
Peritoneal perforation | 12.04 | 9.74 | 6 | 112310 | 124 | 46573622 |
Therapeutic product effect incomplete | 12.01 | 9.74 | 125 | 112191 | 78028 | 46495718 |
Femur fracture | 12.00 | 9.74 | 47 | 112269 | 36950 | 46536796 |
Inhibitory drug interaction | 11.94 | 9.74 | 19 | 112297 | 1976 | 46571770 |
Anticholinergic syndrome | 11.93 | 9.74 | 18 | 112298 | 1788 | 46571958 |
Thinking abnormal | 11.89 | 9.74 | 51 | 112265 | 9763 | 46563983 |
Jaundice | 11.87 | 9.74 | 33 | 112283 | 28812 | 46544934 |
Gamma-glutamyltransferase increased | 11.85 | 9.74 | 38 | 112278 | 31702 | 46542044 |
Live birth | 11.84 | 9.74 | 5 | 112311 | 10325 | 46563421 |
Nephrectomy | 11.79 | 9.74 | 10 | 112306 | 525 | 46573221 |
Skin sensitisation | 11.73 | 9.74 | 12 | 112304 | 801 | 46572945 |
Dyspnoea | 11.66 | 9.74 | 1075 | 111241 | 514473 | 46059273 |
Holmes-Adie pupil | 11.53 | 9.74 | 4 | 112312 | 31 | 46573715 |
Cholelithiasis | 11.51 | 9.74 | 143 | 112173 | 38538 | 46535208 |
Urinary incontinence | 11.49 | 9.74 | 112 | 112204 | 28418 | 46545328 |
False positive investigation result | 11.46 | 9.74 | 10 | 112306 | 546 | 46573200 |
Pyelonephritis | 11.45 | 9.74 | 12 | 112304 | 15345 | 46558401 |
Pericardial effusion | 11.45 | 9.74 | 28 | 112288 | 25515 | 46548231 |
Erythema | 11.42 | 9.74 | 259 | 112057 | 142561 | 46431185 |
Alanine aminotransferase decreased | 11.39 | 9.74 | 10 | 112306 | 550 | 46573196 |
Aspartate aminotransferase decreased | 11.38 | 9.74 | 10 | 112306 | 551 | 46573195 |
Cerebral haemorrhage | 11.28 | 9.74 | 33 | 112283 | 28338 | 46545408 |
Caesarean section | 11.27 | 9.74 | 14 | 112302 | 16589 | 46557157 |
Basal cell carcinoma | 11.25 | 9.74 | 20 | 112296 | 20467 | 46553279 |
Delusion | 11.22 | 9.74 | 55 | 112261 | 11133 | 46562613 |
Wandering pacemaker | 11.22 | 9.74 | 3 | 112313 | 8 | 46573738 |
Disorientation | 11.20 | 9.74 | 137 | 112179 | 36781 | 46536965 |
Pregnancy | 11.20 | 9.74 | 31 | 112285 | 27106 | 46546640 |
Clonus | 11.17 | 9.74 | 28 | 112288 | 4052 | 46569694 |
Small for dates baby | 11.07 | 9.74 | 26 | 112290 | 3611 | 46570135 |
Road traffic accident | 11.06 | 9.74 | 96 | 112220 | 23595 | 46550151 |
Acute myeloid leukaemia | 11.03 | 9.74 | 13 | 112303 | 15765 | 46557981 |
Generalised oedema | 11.03 | 9.74 | 11 | 112305 | 14388 | 46559358 |
Product packaging difficult to open | 11.01 | 9.74 | 4 | 112312 | 36 | 46573710 |
Dysphagia | 10.86 | 9.74 | 253 | 112063 | 77059 | 46496687 |
Body temperature decreased | 10.77 | 9.74 | 62 | 112254 | 13347 | 46560399 |
Peritonitis | 10.69 | 9.74 | 21 | 112295 | 20693 | 46553053 |
Drug eruption | 10.69 | 9.74 | 22 | 112294 | 21307 | 46552439 |
Electrocardiogram T wave inversion | 10.55 | 9.74 | 25 | 112291 | 3491 | 46570255 |
Product substitution issue | 10.49 | 9.74 | 67 | 112249 | 14964 | 46558782 |
Autonomic nervous system imbalance | 10.47 | 9.74 | 20 | 112296 | 2406 | 46571340 |
Economic problem | 10.43 | 9.74 | 18 | 112298 | 2002 | 46571744 |
Tobacco user | 10.40 | 9.74 | 11 | 112305 | 763 | 46572983 |
Foetal death | 10.40 | 9.74 | 4 | 112312 | 8739 | 46565007 |
Incoherent | 10.35 | 9.74 | 29 | 112287 | 4483 | 46569263 |
Dystonia | 10.35 | 9.74 | 54 | 112262 | 11203 | 46562543 |
Anaphylactic reaction | 10.33 | 9.74 | 80 | 112236 | 53032 | 46520714 |
Anoxia | 10.32 | 9.74 | 7 | 112309 | 262 | 46573484 |
Accidental overdose | 10.26 | 9.74 | 83 | 112233 | 19983 | 46553763 |
Epistaxis | 10.23 | 9.74 | 102 | 112214 | 64203 | 46509543 |
Thyroglobulin increased | 10.22 | 9.74 | 4 | 112312 | 45 | 46573701 |
Tuberculosis | 10.21 | 9.74 | 6 | 112310 | 10259 | 46563487 |
Thrombosis | 10.19 | 9.74 | 86 | 112230 | 55983 | 46517763 |
Helicobacter infection | 10.15 | 9.74 | 8 | 112308 | 11728 | 46562018 |
Flat affect | 10.13 | 9.74 | 14 | 112302 | 1284 | 46572462 |
Heterophoria | 10.11 | 9.74 | 3 | 112313 | 13 | 46573733 |
Dyskinesia oesophageal | 10.11 | 9.74 | 3 | 112313 | 13 | 46573733 |
Apraxia | 10.09 | 9.74 | 16 | 112300 | 1659 | 46572087 |
Increased appetite | 10.09 | 9.74 | 44 | 112272 | 8483 | 46565263 |
Impulsive behaviour | 9.87 | 9.74 | 15 | 112301 | 1500 | 46572246 |
Apathy | 9.77 | 9.74 | 39 | 112277 | 7229 | 46566517 |
Gastric ulcer | 9.77 | 9.74 | 24 | 112292 | 21839 | 46551907 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Priapism | 646.49 | 10.63 | 263 | 53892 | 4480 | 29893843 |
Completed suicide | 606.10 | 10.63 | 819 | 53336 | 98673 | 29799650 |
Serotonin syndrome | 488.33 | 10.63 | 338 | 53817 | 17553 | 29880770 |
Drug abuse | 317.80 | 10.63 | 548 | 53607 | 81524 | 29816799 |
Toxicity to various agents | 314.32 | 10.63 | 862 | 53293 | 176321 | 29722002 |
Sopor | 163.19 | 10.63 | 145 | 54010 | 10846 | 29887477 |
Insomnia | 136.91 | 10.63 | 425 | 53730 | 92911 | 29805412 |
Suicidal ideation | 136.69 | 10.63 | 239 | 53916 | 35875 | 29862448 |
Overdose | 128.31 | 10.63 | 389 | 53766 | 83948 | 29814375 |
Depression | 124.57 | 10.63 | 403 | 53752 | 90034 | 29808289 |
Anxiety | 116.19 | 10.63 | 392 | 53763 | 89479 | 29808844 |
Respiratory arrest | 111.18 | 10.63 | 194 | 53961 | 29064 | 29869259 |
Intentional overdose | 102.96 | 10.63 | 230 | 53925 | 41251 | 29857072 |
Agitation | 97.27 | 10.63 | 265 | 53890 | 53808 | 29844515 |
Suicide attempt | 96.20 | 10.63 | 208 | 53947 | 36489 | 29861834 |
Electrocardiogram QT prolonged | 80.43 | 10.63 | 191 | 53964 | 35644 | 29862679 |
Febrile neutropenia | 75.59 | 10.63 | 50 | 54105 | 106643 | 29791680 |
Cardio-respiratory arrest | 74.90 | 10.63 | 251 | 53904 | 57055 | 29841268 |
Mental status changes | 65.93 | 10.63 | 181 | 53974 | 36898 | 29861425 |
Ventricular tachyarrhythmia | 63.66 | 10.63 | 23 | 54132 | 278 | 29898045 |
Thrombocytopenia | 58.16 | 10.63 | 99 | 54056 | 136945 | 29761378 |
Anaemia | 58.05 | 10.63 | 188 | 53967 | 207804 | 29690519 |
Drug withdrawal syndrome | 57.38 | 10.63 | 117 | 54038 | 19692 | 29878631 |
Drug interaction | 54.66 | 10.63 | 576 | 53579 | 198992 | 29699331 |
Tremor | 53.14 | 10.63 | 273 | 53882 | 75090 | 29823233 |
Aggression | 53.02 | 10.63 | 167 | 53988 | 36740 | 29861583 |
Tardive dyskinesia | 51.06 | 10.63 | 54 | 54101 | 5003 | 29893320 |
Poisoning | 50.60 | 10.63 | 81 | 54074 | 11301 | 29887022 |
Intentional product misuse | 49.01 | 10.63 | 156 | 53999 | 34511 | 29863812 |
Confusional state | 48.77 | 10.63 | 413 | 53742 | 134421 | 29763902 |
Renal impairment | 45.54 | 10.63 | 51 | 54104 | 84133 | 29814190 |
Pyrexia | 45.44 | 10.63 | 329 | 53826 | 294160 | 29604163 |
Interstitial lung disease | 44.26 | 10.63 | 27 | 54128 | 60170 | 29838153 |
Somnolence | 43.62 | 10.63 | 312 | 53843 | 96451 | 29801872 |
Intentional self-injury | 41.67 | 10.63 | 82 | 54073 | 13450 | 29884873 |
Antidepressant drug level above therapeutic | 40.10 | 10.63 | 14 | 54141 | 152 | 29898171 |
General physical health deterioration | 39.85 | 10.63 | 75 | 54080 | 99869 | 29798454 |
Neutropenia | 39.52 | 10.63 | 111 | 54044 | 128429 | 29769894 |
Anger | 38.71 | 10.63 | 71 | 54084 | 11049 | 29887274 |
Hepatic function abnormal | 38.22 | 10.63 | 14 | 54141 | 41931 | 29856392 |
Symptom masked | 38.07 | 10.63 | 18 | 54137 | 445 | 29897878 |
Paranoia | 37.96 | 10.63 | 67 | 54088 | 10121 | 29888202 |
Alcoholism | 37.25 | 10.63 | 38 | 54117 | 3376 | 29894947 |
Renal failure | 37.02 | 10.63 | 115 | 54040 | 128851 | 29769472 |
Cardiac arrest | 36.00 | 10.63 | 289 | 53866 | 92561 | 29805762 |
Restlessness | 35.95 | 10.63 | 106 | 54049 | 22493 | 29875830 |
Pancytopenia | 35.54 | 10.63 | 62 | 54093 | 84990 | 29813333 |
Septic shock | 34.98 | 10.63 | 38 | 54117 | 63569 | 29834754 |
Sedation | 34.29 | 10.63 | 85 | 54070 | 16288 | 29882035 |
Irritability | 32.82 | 10.63 | 104 | 54051 | 22946 | 29875377 |
Sleep disorder | 32.64 | 10.63 | 108 | 54047 | 24371 | 29873952 |
Akathisia | 31.88 | 10.63 | 46 | 54109 | 5858 | 29892465 |
Hyperreflexia | 31.70 | 10.63 | 32 | 54123 | 2807 | 29895516 |
Analgesic drug level above therapeutic | 31.37 | 10.63 | 13 | 54142 | 232 | 29898091 |
Parkinsonism | 31.31 | 10.63 | 51 | 54104 | 7218 | 29891105 |
Accidental overdose | 31.27 | 10.63 | 88 | 54067 | 18187 | 29880136 |
Psychotic disorder | 29.65 | 10.63 | 96 | 54059 | 21419 | 29876904 |
Multiple organ dysfunction syndrome | 29.61 | 10.63 | 43 | 54112 | 63444 | 29834879 |
Delusion of replacement | 29.58 | 10.63 | 11 | 54144 | 145 | 29898178 |
Cardiac failure | 29.52 | 10.63 | 67 | 54088 | 83351 | 29814972 |
Disease progression | 29.21 | 10.63 | 63 | 54092 | 79811 | 29818512 |
Environmental exposure | 29.05 | 10.63 | 13 | 54142 | 282 | 29898041 |
Nightmare | 28.86 | 10.63 | 66 | 54089 | 12010 | 29886313 |
Painful erection | 28.82 | 10.63 | 12 | 54143 | 217 | 29898106 |
Granulocytopenia | 28.62 | 10.63 | 45 | 54110 | 6181 | 29892142 |
Delirium | 28.48 | 10.63 | 147 | 54008 | 40484 | 29857839 |
Penis injury | 27.94 | 10.63 | 12 | 54143 | 235 | 29898088 |
Hyperhidrosis | 27.74 | 10.63 | 212 | 53943 | 66878 | 29831445 |
Bradyphrenia | 27.73 | 10.63 | 35 | 54120 | 3922 | 29894401 |
Withdrawal syndrome | 27.46 | 10.63 | 62 | 54093 | 11188 | 29887135 |
Bipolar disorder | 27.42 | 10.63 | 34 | 54121 | 3742 | 29894581 |
Sepsis | 27.40 | 10.63 | 154 | 54001 | 146241 | 29752082 |
Cytomegalovirus infection | 27.08 | 10.63 | 5 | 54150 | 23669 | 29874654 |
Hallucination, visual | 26.99 | 10.63 | 77 | 54078 | 16036 | 29882287 |
Delusion | 26.98 | 10.63 | 64 | 54091 | 11925 | 29886398 |
Clonus | 25.95 | 10.63 | 27 | 54128 | 2454 | 29895869 |
Atrial fibrillation | 25.93 | 10.63 | 104 | 54051 | 108020 | 29790303 |
Nervousness | 25.53 | 10.63 | 62 | 54093 | 11726 | 29886597 |
Dysphoria | 25.44 | 10.63 | 25 | 54130 | 2123 | 29896200 |
Erectile dysfunction | 25.15 | 10.63 | 81 | 54074 | 18021 | 29880302 |
Drug reaction with eosinophilia and systemic symptoms | 25.13 | 10.63 | 10 | 54145 | 28478 | 29869845 |
Acute kidney injury | 24.97 | 10.63 | 347 | 53808 | 273495 | 29624828 |
Compulsive sexual behaviour | 24.57 | 10.63 | 11 | 54144 | 239 | 29898084 |
Neuroleptic malignant syndrome | 24.56 | 10.63 | 75 | 54080 | 16220 | 29882103 |
Homicide | 24.45 | 10.63 | 18 | 54137 | 1028 | 29897295 |
Sexual dysfunction | 24.36 | 10.63 | 41 | 54114 | 5960 | 29892363 |
Platelet count decreased | 24.26 | 10.63 | 104 | 54051 | 106025 | 29792298 |
Polymerase chain reaction | 23.87 | 10.63 | 8 | 54147 | 76 | 29898247 |
Fall | 23.74 | 10.63 | 461 | 53694 | 181411 | 29716912 |
Erection increased | 23.42 | 10.63 | 14 | 54141 | 562 | 29897761 |
Urine amphetamine positive | 23.38 | 10.63 | 6 | 54149 | 19 | 29898304 |
Persistent depressive disorder | 23.37 | 10.63 | 11 | 54144 | 269 | 29898054 |
Pruritus genital | 23.36 | 10.63 | 13 | 54142 | 455 | 29897868 |
Post-traumatic stress disorder | 23.36 | 10.63 | 21 | 54134 | 1594 | 29896729 |
Initial insomnia | 23.26 | 10.63 | 26 | 54129 | 2563 | 29895760 |
Hallucination | 22.55 | 10.63 | 159 | 53996 | 48900 | 29849423 |
Malignant neoplasm progression | 22.50 | 10.63 | 62 | 54093 | 72225 | 29826098 |
Dry mouth | 22.20 | 10.63 | 91 | 54064 | 22759 | 29875564 |
Substance abuse | 22.08 | 10.63 | 43 | 54112 | 6997 | 29891326 |
Dyspnoea | 22.01 | 10.63 | 448 | 53707 | 332847 | 29565476 |
Depersonalisation/derealisation disorder | 21.93 | 10.63 | 13 | 54142 | 514 | 29897809 |
Injection site reaction | 21.63 | 10.63 | 55 | 54100 | 10705 | 29887618 |
Cholestasis | 21.62 | 10.63 | 9 | 54146 | 24941 | 29873382 |
Thinking abnormal | 21.18 | 10.63 | 36 | 54119 | 5275 | 29893048 |
Euphoric mood | 21.11 | 10.63 | 32 | 54123 | 4258 | 29894065 |
Bone marrow failure | 21.01 | 10.63 | 14 | 54141 | 29771 | 29868552 |
Cogwheel rigidity | 20.99 | 10.63 | 17 | 54138 | 1119 | 29897204 |
Hallucination, auditory | 20.68 | 10.63 | 51 | 54104 | 9738 | 29888585 |
Drug screen positive | 20.46 | 10.63 | 32 | 54123 | 4375 | 29893948 |
Restless legs syndrome | 20.38 | 10.63 | 41 | 54114 | 6831 | 29891492 |
Dementia | 20.34 | 10.63 | 59 | 54096 | 12402 | 29885921 |
Poor feeding infant | 20.17 | 10.63 | 11 | 54144 | 370 | 29897953 |
Poor quality sleep | 20.06 | 10.63 | 42 | 54113 | 7199 | 29891124 |
Nicotine dependence | 19.78 | 10.63 | 10 | 54145 | 287 | 29898036 |
Abnormal behaviour | 19.57 | 10.63 | 95 | 54060 | 25528 | 29872795 |
Food aversion | 19.47 | 10.63 | 10 | 54145 | 297 | 29898026 |
Mucosal inflammation | 19.35 | 10.63 | 16 | 54139 | 30478 | 29867845 |
Drug dependence | 19.28 | 10.63 | 83 | 54072 | 21212 | 29877111 |
Haemoglobin decreased | 19.24 | 10.63 | 124 | 54031 | 113974 | 29784349 |
Catatonia | 19.23 | 10.63 | 31 | 54124 | 4349 | 29893974 |
Muscle rigidity | 19.14 | 10.63 | 51 | 54104 | 10210 | 29888113 |
Obsessive thoughts | 19.05 | 10.63 | 13 | 54142 | 658 | 29897665 |
Myotonia | 18.92 | 10.63 | 6 | 54149 | 47 | 29898276 |
Psychomotor hyperactivity | 18.61 | 10.63 | 44 | 54111 | 8180 | 29890143 |
Illness anxiety disorder | 18.29 | 10.63 | 8 | 54147 | 164 | 29898159 |
Acute myeloid leukaemia | 18.20 | 10.63 | 5 | 54150 | 18001 | 29880322 |
Lung disorder | 18.20 | 10.63 | 18 | 54137 | 31451 | 29866872 |
Infection | 18.14 | 10.63 | 76 | 54079 | 77998 | 29820325 |
Congenital pneumonia | 18.13 | 10.63 | 7 | 54148 | 103 | 29898220 |
Hepatic failure | 17.98 | 10.63 | 21 | 54134 | 34022 | 29864301 |
Hepatocellular injury | 17.93 | 10.63 | 12 | 54143 | 25459 | 29872864 |
Drug resistance | 17.87 | 10.63 | 7 | 54148 | 20126 | 29878197 |
C-reactive protein increased | 17.86 | 10.63 | 32 | 54123 | 43441 | 29854882 |
Rash maculo-papular | 17.85 | 10.63 | 12 | 54143 | 25406 | 29872917 |
Substance use disorder | 17.82 | 10.63 | 7 | 54148 | 108 | 29898215 |
Penile haemorrhage | 17.69 | 10.63 | 12 | 54143 | 601 | 29897722 |
Hangover | 17.56 | 10.63 | 15 | 54140 | 1063 | 29897260 |
Depressed mood | 17.48 | 10.63 | 69 | 54086 | 16960 | 29881363 |
Ascites | 17.07 | 10.63 | 24 | 54131 | 35897 | 29862426 |
Procedural failure | 17.03 | 10.63 | 6 | 54149 | 67 | 29898256 |
Lethargy | 16.95 | 10.63 | 126 | 54029 | 39393 | 29858930 |
Generalised anxiety disorder | 16.86 | 10.63 | 12 | 54143 | 650 | 29897673 |
Sleep-related eating disorder | 16.82 | 10.63 | 9 | 54146 | 291 | 29898032 |
Blood cholinesterase decreased | 16.74 | 10.63 | 7 | 54148 | 128 | 29898195 |
Myocardial infarction | 16.67 | 10.63 | 146 | 54009 | 125479 | 29772844 |
Personality disorder | 16.67 | 10.63 | 15 | 54140 | 1140 | 29897183 |
Respiratory failure | 16.65 | 10.63 | 110 | 54045 | 100532 | 29797791 |
Exposure via ingestion | 16.58 | 10.63 | 22 | 54133 | 2589 | 29895734 |
Sleep deficit | 16.39 | 10.63 | 10 | 54145 | 417 | 29897906 |
Brain injury | 16.33 | 10.63 | 33 | 54122 | 5515 | 29892808 |
Neck pain | 16.25 | 10.63 | 78 | 54077 | 20866 | 29877457 |
Cough | 16.24 | 10.63 | 147 | 54008 | 125495 | 29772828 |
Myoclonus | 16.22 | 10.63 | 57 | 54098 | 13255 | 29885068 |
Pre-existing condition improved | 16.13 | 10.63 | 19 | 54136 | 1982 | 29896341 |
Rash | 16.11 | 10.63 | 247 | 53908 | 191642 | 29706681 |
Homicidal ideation | 16.03 | 10.63 | 21 | 54134 | 2442 | 29895881 |
Bite | 16.01 | 10.63 | 5 | 54150 | 37 | 29898286 |
Amputation of penis | 15.95 | 10.63 | 3 | 54152 | 0 | 29898323 |
Blood bilirubin increased | 15.94 | 10.63 | 26 | 54129 | 36610 | 29861713 |
Stress at work | 15.89 | 10.63 | 7 | 54148 | 146 | 29898177 |
Abnormal dreams | 15.81 | 10.63 | 41 | 54114 | 8074 | 29890249 |
Product administered at inappropriate site | 15.70 | 10.63 | 17 | 54138 | 1618 | 29896705 |
Hostility | 15.66 | 10.63 | 13 | 54142 | 886 | 29897437 |
Economic problem | 15.50 | 10.63 | 16 | 54139 | 1441 | 29896882 |
Weight increased | 15.45 | 10.63 | 205 | 53950 | 74708 | 29823615 |
Obsessive-compulsive disorder | 15.12 | 10.63 | 27 | 54128 | 4114 | 29894209 |
Disorientation | 15.12 | 10.63 | 103 | 54052 | 31315 | 29867008 |
Pneumocystis jirovecii pneumonia | 15.12 | 10.63 | 6 | 54149 | 17114 | 29881209 |
Blood creatinine increased | 15.04 | 10.63 | 100 | 54055 | 91275 | 29807048 |
Intestinal obstruction | 15.00 | 10.63 | 8 | 54147 | 19204 | 29879119 |
Drug tolerance | 14.95 | 10.63 | 19 | 54136 | 2143 | 29896180 |
Penile vein thrombosis | 14.67 | 10.63 | 4 | 54151 | 17 | 29898306 |
Lower respiratory tract infection | 14.63 | 10.63 | 16 | 54139 | 26698 | 29871625 |
Dyskinesia | 14.61 | 10.63 | 78 | 54077 | 21756 | 29876567 |
Bruxism | 14.60 | 10.63 | 15 | 54140 | 1344 | 29896979 |
Homeless | 14.48 | 10.63 | 4 | 54151 | 18 | 29898305 |
Periorbital haemorrhage | 14.33 | 10.63 | 6 | 54149 | 110 | 29898213 |
C-reactive protein | 14.23 | 10.63 | 6 | 54149 | 112 | 29898211 |
Self-injurious ideation | 14.19 | 10.63 | 16 | 54139 | 1593 | 29896730 |
Jaundice | 14.18 | 10.63 | 23 | 54132 | 32463 | 29865860 |
Shock | 14.18 | 10.63 | 80 | 54075 | 22779 | 29875544 |
Dysarthria | 14.11 | 10.63 | 99 | 54056 | 30391 | 29867932 |
Extrapyramidal disorder | 14.09 | 10.63 | 47 | 54108 | 10646 | 29887677 |
Hanging | 14.09 | 10.63 | 6 | 54149 | 115 | 29898208 |
Flat affect | 14.07 | 10.63 | 12 | 54143 | 849 | 29897474 |
Hypertonia | 14.02 | 10.63 | 27 | 54128 | 4358 | 29893965 |
Foaming at mouth | 14.01 | 10.63 | 11 | 54144 | 692 | 29897631 |
Product dose omission issue | 13.94 | 10.63 | 238 | 53917 | 91393 | 29806930 |
Sleep sex | 13.88 | 10.63 | 3 | 54152 | 3 | 29898320 |
Peritonitis | 13.83 | 10.63 | 11 | 54144 | 21364 | 29876959 |
White blood cell count decreased | 13.75 | 10.63 | 92 | 54063 | 83855 | 29814468 |
Disseminated intravascular coagulation | 13.62 | 10.63 | 12 | 54143 | 22159 | 29876164 |
Eosinophilia | 13.61 | 10.63 | 12 | 54143 | 22148 | 29876175 |
Cardiac failure congestive | 13.58 | 10.63 | 93 | 54062 | 84314 | 29814009 |
Unresponsive to stimuli | 13.55 | 10.63 | 88 | 54067 | 26331 | 29871992 |
Memory impairment | 13.46 | 10.63 | 114 | 54041 | 37060 | 29861263 |
Diabetic foetopathy | 13.30 | 10.63 | 7 | 54148 | 219 | 29898104 |
Urine leukocyte esterase positive | 13.23 | 10.63 | 8 | 54147 | 328 | 29897995 |
Bronchopulmonary aspergillosis | 13.21 | 10.63 | 3 | 54152 | 12281 | 29886042 |
Penile necrosis | 13.17 | 10.63 | 5 | 54150 | 70 | 29898253 |
Erythema | 13.13 | 10.63 | 84 | 54071 | 77367 | 29820956 |
Panic attack | 13.12 | 10.63 | 40 | 54115 | 8641 | 29889682 |
Toxicologic test abnormal | 13.11 | 10.63 | 10 | 54145 | 603 | 29897720 |
Alcohol use | 13.10 | 10.63 | 24 | 54131 | 3731 | 29894592 |
Amnesia | 13.08 | 10.63 | 82 | 54073 | 24239 | 29874084 |
Alcohol poisoning | 13.06 | 10.63 | 24 | 54131 | 3740 | 29894583 |
Myelodysplastic syndrome | 13.01 | 10.63 | 9 | 54146 | 18769 | 29879554 |
Reduced facial expression | 13.01 | 10.63 | 11 | 54144 | 769 | 29897554 |
Dizziness | 13.00 | 10.63 | 452 | 53703 | 194457 | 29703866 |
Ephelides | 12.98 | 10.63 | 5 | 54150 | 73 | 29898250 |
Withdrawal catatonia | 12.98 | 10.63 | 5 | 54150 | 73 | 29898250 |
Osteonecrosis of jaw | 12.80 | 10.63 | 9 | 54146 | 18609 | 29879714 |
Drug abuser | 12.75 | 10.63 | 26 | 54129 | 4375 | 29893948 |
Paedophilia | 12.67 | 10.63 | 3 | 54152 | 6 | 29898317 |
Delirium febrile | 12.65 | 10.63 | 4 | 54151 | 31 | 29898292 |
Wrong patient received product | 12.62 | 10.63 | 16 | 54139 | 1801 | 29896522 |
General symptom | 12.46 | 10.63 | 11 | 54144 | 815 | 29897508 |
Alanine aminotransferase increased | 12.37 | 10.63 | 81 | 54074 | 74195 | 29824128 |
Pneumonia | 12.36 | 10.63 | 487 | 53668 | 333819 | 29564504 |
Obsessive rumination | 12.35 | 10.63 | 3 | 54152 | 7 | 29898316 |
Libido increased | 12.26 | 10.63 | 11 | 54144 | 833 | 29897490 |
Pleural effusion | 12.22 | 10.63 | 81 | 54074 | 73985 | 29824338 |
Discoloured vomit | 12.14 | 10.63 | 8 | 54147 | 382 | 29897941 |
Psychomotor retardation | 12.07 | 10.63 | 18 | 54137 | 2361 | 29895962 |
Vascular encephalopathy | 12.03 | 10.63 | 5 | 54150 | 90 | 29898233 |
Heat stroke | 11.97 | 10.63 | 11 | 54144 | 859 | 29897464 |
Major depression | 11.93 | 10.63 | 24 | 54131 | 3998 | 29894325 |
Toxic epidermal necrolysis | 11.90 | 10.63 | 9 | 54146 | 17931 | 29880392 |
Palmar-plantar erythrodysaesthesia syndrome | 11.89 | 10.63 | 6 | 54149 | 14864 | 29883459 |
Pruritus | 11.75 | 10.63 | 147 | 54008 | 118057 | 29780266 |
Terminal insomnia | 11.68 | 10.63 | 8 | 54147 | 407 | 29897916 |
Product reconstitution quality issue | 11.59 | 10.63 | 5 | 54150 | 99 | 29898224 |
Feeling abnormal | 11.57 | 10.63 | 155 | 54000 | 56601 | 29841722 |
Thyroiditis acute | 11.32 | 10.63 | 5 | 54150 | 105 | 29898218 |
Foetal exposure during pregnancy | 11.19 | 10.63 | 32 | 54123 | 36839 | 29861484 |
Feelings of worthlessness | 11.08 | 10.63 | 6 | 54149 | 199 | 29898124 |
Gambling disorder | 10.92 | 10.63 | 15 | 54140 | 1825 | 29896498 |
Sinus bradycardia | 10.90 | 10.63 | 46 | 54109 | 11649 | 29886674 |
Ejaculation failure | 10.80 | 10.63 | 10 | 54145 | 788 | 29897535 |
Alcohol withdrawal syndrome | 10.76 | 10.63 | 14 | 54141 | 1617 | 29896706 |
Drug withdrawal syndrome neonatal | 10.71 | 10.63 | 20 | 54135 | 3155 | 29895168 |
Device related infection | 10.71 | 10.63 | 9 | 54146 | 17006 | 29881317 |
Colitis | 10.69 | 10.63 | 25 | 54130 | 30795 | 29867528 |
Bipolar I disorder | 10.69 | 10.63 | 10 | 54145 | 799 | 29897524 |
Source | Code | Description |
---|---|---|
ATC | N06AX05 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Other antidepressants |
FDA EPC | N0000175696 | Serotonin Reuptake Inhibitor |
MeSH PA | D014151 | Anti-Anxiety Agents |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D018687 | Antidepressive Agents, Second-Generation |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D018490 | Serotonin Agents |
MeSH PA | D017367 | Serotonin Uptake Inhibitors |
MeSH PA | D014149 | Tranquilizing Agents |
CHEBI has role | CHEBI:35469 | thymoanaleptics |
CHEBI has role | CHEBI:35474 | minor tranquilisers |
CHEBI has role | CHEBI:35717 | sedatives |
CHEBI has role | CHEBI:37887 | adrenergic receptor blockaders |
CHEBI has role | CHEBI:37955 | h1-receptor blockers |
CHEBI has role | CHEBI:50949 | serotonin reuptake inhibitor |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Major depressive disorder | indication | 370143000 | |
Insomnia | off-label use | 193462001 | |
Priapism | contraindication | 6273006 | DOID:9286 |
Suicidal thoughts | contraindication | 6471006 | |
Orthostatic hypotension | contraindication | 28651003 | |
Torsades de pointes | contraindication | 31722008 | |
Hypokalemia | contraindication | 43339004 | |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Heart disease | contraindication | 56265001 | DOID:114 |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Prolonged QT interval | contraindication | 111975006 | |
Hypomagnesemia | contraindication | 190855004 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Myocardial infarction in recovery phase | contraindication | 418044006 | |
Congenital long QT syndrome | contraindication | 442917000 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 6.98 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 2C | GPCR | ANTAGONIST | Ki | 6.65 | WOMBAT-PK | CHEMBL | |||
5-hydroxytryptamine receptor 2A | GPCR | ANTAGONIST | Ki | 7.35 | WOMBAT-PK | CHEMBL | |||
Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Kd | 6.80 | WOMBAT-PK | CHEMBL | |||
Alpha-2C adrenergic receptor | GPCR | Ki | 6.81 | PDSP | |||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.03 | DRUG MATRIX | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 6.75 | DRUG MATRIX | |||||
D(3) dopamine receptor | GPCR | Ki | 5.90 | DRUG MATRIX | |||||
Alpha-1D adrenergic receptor | GPCR | Ki | 7.33 | DRUG MATRIX | |||||
Sodium-dependent dopamine transporter | Transporter | Kd | 5.13 | WOMBAT-PK | |||||
Histamine H1 receptor | GPCR | Ki | 6.21 | WOMBAT-PK | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 9.55 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 7.08 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 7.02 | WOMBAT-PK | |||||
Sodium-dependent noradrenaline transporter | Transporter | Kd | 5.07 | WOMBAT-PK | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.54 | WOMBAT-PK | |||||
Alpha-2A adrenergic receptor | GPCR | Ki | 6.58 | WOMBAT-PK | |||||
D(4) dopamine receptor | GPCR | Ki | 6.15 | PDSP | |||||
5-hydroxytryptamine receptor 7 | GPCR | Ki | 5.75 | PDSP | |||||
D(2) dopamine receptor | GPCR | Ki | 5.46 | PDSP | |||||
D(1A) dopamine receptor | GPCR | Ki | 5.43 | PDSP | |||||
5-hydroxytryptamine receptor 1D | GPCR | Ki | 6.97 | PDSP | |||||
Histamine H2 receptor | GPCR | Ki | 5.48 | PDSP | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 7.21 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 1B | GPCR | Ki | 6.08 | DRUG MATRIX | |||||
Membrane-associated progesterone receptor component 1 | Membrane receptor | Ki | 6.08 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2A | GPCR | IC50 | 7.77 | CHEMBL | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 6.65 | CHEMBL | |||||
5-hydroxytryptamine receptor 2C | GPCR | ANTAGONIST | Ki | 6.70 | IUPHAR | ||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 6.93 | CHEMBL |
ID | Source |
---|---|
4019954 | VUID |
N0000148039 | NUI |
D00820 | KEGG_DRUG |
25332-39-2 | SECONDARY_CAS_RN |
4018812 | VANDF |
4019954 | VANDF |
C0040805 | UMLSCUI |
CHEBI:9654 | CHEBI |
CHEMBL621 | ChEMBL_ID |
CHEMBL1200798 | ChEMBL_ID |
D014196 | MESH_DESCRIPTOR_UI |
2878 | INN_ID |
DB00656 | DRUGBANK_ID |
YBK48BXK30 | UNII |
5533 | PUBCHEM_CID |
213 | IUPHAR_LIGAND_ID |
10737 | RXNORM |
1504 | MMSL |
5609 | MMSL |
d00395 | MMSL |
001511 | NDDF |
004610 | NDDF |
372829000 | SNOMEDCT_US |
58956008 | SNOMEDCT_US |
7336002 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0733 | TABLET | 300 mg | ORAL | ANDA | 26 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-6160 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 29 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-6161 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 29 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-2578 | TABLET | 50 mg | ORAL | ANDA | 31 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-2579 | TABLET | 100 mg | ORAL | ANDA | 31 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8155 | TABLET | 150 mg | ORAL | ANDA | 30 sections |
TRAZODONE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8339 | TABLET | 150 mg | ORAL | ANDA | 31 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8371 | TABLET | 50 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8386 | TABLET | 100 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6554 | TABLET | 50 mg | ORAL | ANDA | 21 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6555 | TABLET | 100 mg | ORAL | ANDA | 21 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6868 | TABLET | 50 mg | ORAL | ANDA | 27 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6869 | TABLET | 100 mg | ORAL | ANDA | 27 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-532 | TABLET | 100 mg | ORAL | ANDA | 31 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-533 | TABLET | 150 mg | ORAL | ANDA | 24 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-534 | TABLET | 50 mg | ORAL | ANDA | 30 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-867 | TABLET | 150 mg | ORAL | ANDA | 21 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-193 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 31 sections |
Trazodone Hydrochloride | Human Prescription Drug Label | 1 | 13107-079 | TABLET | 50 mg | ORAL | ANDA | 29 sections |
Trazodone Hydrochloride | Human Prescription Drug Label | 1 | 13107-080 | TABLET | 100 mg | ORAL | ANDA | 29 sections |
Trazodone Hydrochloride | Human Prescription Drug Label | 1 | 13107-081 | TABLET | 150 mg | ORAL | ANDA | 29 sections |
Trazodone Hydrochloride | Human Prescription Drug Label | 1 | 13107-082 | TABLET | 300 mg | ORAL | ANDA | 29 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-330 | TABLET | 50 mg | ORAL | ANDA | 22 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-331 | TABLET | 100 mg | ORAL | ANDA | 22 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-332 | TABLET | 150 mg | ORAL | ANDA | 22 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-333 | TABLET | 300 mg | ORAL | ANDA | 22 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-231 | TABLET | 50 mg | ORAL | ANDA | 25 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-232 | TABLET | 100 mg | ORAL | ANDA | 25 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-585 | TABLET | 150 mg | ORAL | ANDA | 25 sections |
Trazodone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-299 | TABLET | 50 mg | ORAL | ANDA | 20 sections |