temafloxacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibacterials, nalidixic acid derivatives 2584 108319-06-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • A 62254
  • temafloxacin HCl
  • A-62254
  • temafloxacin
  • teflox
  • temafloxacin hydrochloride
  • Molecular weight: 417.39
  • Formula: C21H18F3N3O3
  • CLOGP: 0.93
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 72.88
  • ALOGS: -4.46
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.80 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Bocci G, Oprea TI, Benet LZ
BA (Bioavailability) 95 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility) 0.11 mg/mL Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class GRK2,PDK1,PDK2,PDK4 4
kinase-selectivity-class ACVR2B,AXL,CAMK2D,CDK9,DYRK1B,EIF2AK3,GRK2,MAPK7,PDK4,PIK3CB,PRKDC,SIK2,STK33,TTK 14
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01MA05 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
QUINOLONE ANTIBACTERIALS
Fluoroquinolones
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059003 Topoisomerase Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:36047 antibacterial drug
CHEBI has role CHEBI:50750 EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor

Related Drugs by ATC class:

J01MA Fluoroquinolones 22 drugs
ciprofloxacindelafloxacinenoxacinfleroxacingarenoxacingatifloxacingemifloxacingrepafloxacinlascufloxacinlevofloxacinlomefloxacinmoxifloxacin show all 22 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.76 acidic
pKa2 8.66 Basic
pKa3 0.91 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4020512 VUID
N0000148234 NUI
4020456 VANDF
4020512 VANDF
C0076075 UMLSCUI
CHEBI:77788 CHEBI
CHEMBL277100 ChEMBL_ID
CHEMBL2107495 ChEMBL_ID
DB01405 DRUGBANK_ID
C054745 MESH_SUPPLEMENTAL_RECORD_UI
60021 PUBCHEM_CID
10866 IUPHAR_LIGAND_ID
6224 INN_ID
1WZ12GTT67 UNII
295217 RXNORM
003636 NDDF
003637 NDDF
387555009 SNOMEDCT_US
96091001 SNOMEDCT_US
105784-61-0 SECONDARY_CAS_RN

Pharmaceutical products:

None