talbutal 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
hypnotics, barbituric acid derivatives 2556 115-44-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • profundol
  • 5-Allyl-5-sec-butylbarbituric acid
  • lotusate
  • 5-Allyl-5-(1-methylpropyl) barbituric acid
  • talbutal
  • Molecular weight: 224.26
  • Formula: C11H16N2O3
  • CLOGP: 1.63
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 75.27
  • ALOGS: -1.96
  • ROTB: 4
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP3K21,MAPK7,NTRK2,PDK1,PDK2,PRKDC,STK33,TEK 20
kinase-selectivity-class AXL,CDK9,GRK2,MAPK7,PDK1,TEK 6
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05CA07 NERVOUS SYSTEM
PSYCHOLEPTICS
HYPNOTICS AND SEDATIVES
Barbiturates, plain

Related Drugs by ATC class:

N05CA Barbiturates, plain 17 drugs
allobarbitalamobarbitalaprobarbitalbarbitalbutobarbitalcyclobarbitaletallobarbitalheptabarbhexobarbitalmethohexitalpentobarbitalproxibarbal show all 17 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Insomnia indication 193462001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.79 acidic
pKa2 9.48 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
GABA-A receptor; anion channel Ion channel POSITIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL

External reference:

IDSource
4018243 VUID
N0000146574 NUI
D06887 KEGG_DRUG
4018243 VANDF
C0301407 UMLSCUI
CHEBI:134923 CHEBI
CHEMBL1200802 ChEMBL_ID
DB00306 DRUGBANK_ID
8275 PUBCHEM_CID
C446080 MESH_SUPPLEMENTAL_RECORD_UI
6 INN_ID
4YIR8202AX UNII
89810 RXNORM
001425 NDDF
76190009 SNOMEDCT_US

Pharmaceutical products:

None