tacrolimus ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
immunosuppressants, rapamycin derivatives 2552 104987-11-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • FK-506
  • tacrolimus hydrate
  • tacrolimus
  • fujimycin
  • tsukubaenolide
  • anhydrous tacrolimus
  • tacrolimus anhydrous
  • modigraf
  • FR900506
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
  • Molecular weight: 804.03
  • Formula: C44H69NO12
  • CLOGP: 5.78
  • LIPINSKI: 3
  • HAC: 13
  • HDO: 3
  • TPSA: 178.36
  • ALOGS: -5.30
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
5 mg O
5 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.24 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 25 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 26 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 27, 2002 EMA LEO PHARMA A/S
April 8, 1994 FDA ASTELLAS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Transplant rejection 4232.28 11.04 1362 133492 9418 63344750
Cytomegalovirus infection 2816.11 11.04 1204 133650 19748 63334420
Post transplant lymphoproliferative disorder 2600.85 11.04 785 134069 4246 63349922
Thrombotic microangiopathy 2109.06 11.04 807 134047 9754 63344414
Immunosuppressant drug level increased 1589.38 11.04 499 134355 3139 63351029
Kidney transplant rejection 1434.83 11.04 480 134374 3791 63350377
Transplant dysfunction 1326.97 11.04 468 134386 4404 63349764
Epstein-Barr virus infection 1273.75 11.04 520 134334 7530 63346638
Cytomegalovirus viraemia 1125.19 11.04 431 134423 5218 63348950
Polyomavirus-associated nephropathy 1119.06 11.04 326 134528 1522 63352646
Product use in unapproved indication 1117.90 11.04 1623 133231 177457 63176711
BK virus infection 993.22 11.04 341 134513 2938 63351230
Posterior reversible encephalopathy syndrome 944.96 11.04 539 134315 16806 63337362
Complications of transplanted kidney 901.40 11.04 296 134558 2190 63351978
Liver transplant rejection 841.81 11.04 247 134607 1188 63352980
Acute graft versus host disease 765.84 11.04 305 134549 4123 63350045
Fatigue 763.65 11.04 475 134379 887553 62466615
Graft versus host disease 763.26 11.04 344 134510 6419 63347749
Renal impairment 684.82 11.04 890 133964 87465 63266703
Multiple organ dysfunction syndrome 660.20 11.04 704 134150 56048 63298120
Off label use 653.22 11.04 2992 131862 671470 62682698
Drug level increased 621.23 11.04 458 134396 22278 63331890
Acute graft versus host disease in skin 590.81 11.04 236 134618 3216 63350952
Chronic graft versus host disease 586.80 11.04 228 134626 2874 63351294
Pneumocystis jirovecii pneumonia 571.65 11.04 388 134466 16526 63337642
Bronchopulmonary aspergillosis 571.05 11.04 305 134549 8330 63345838
Aspergillus infection 566.75 11.04 297 134557 7796 63346372
Nephropathy toxic 547.12 11.04 306 134548 9173 63344995
Drug interaction 539.56 11.04 1372 133482 227759 63126409
Transplant failure 535.73 11.04 179 134675 1406 63352762
Cytomegalovirus infection reactivation 503.25 11.04 219 134635 3744 63350424
Arthralgia 494.78 11.04 300 134554 569410 62784758
Nocardiosis 493.34 11.04 178 134676 1798 63352370
Acute kidney injury 488.46 11.04 1445 133409 261970 63092198
Trichodysplasia spinulosa 482.29 11.04 131 134723 446 63353722
Pain 477.20 11.04 524 134330 740104 62614064
COVID-19 469.50 11.04 853 134001 112250 63241918
Immunosuppressant drug level decreased 462.23 11.04 142 134712 821 63353347
Joint swelling 459.82 11.04 73 134781 327593 63026575
Premature delivery 449.89 11.04 429 134425 29852 63324316
Ovarian cyst 448.66 11.04 327 134527 15618 63338550
Arthropathy 435.56 11.04 14 134840 234778 63119390
Smooth muscle cell neoplasm 433.50 11.04 131 134723 710 63353458
Delayed graft function 432.21 11.04 139 134715 954 63353214
Klebsiella infection 428.73 11.04 252 134602 8314 63345854
Renal transplant failure 424.38 11.04 126 134728 636 63353532
Diffuse large B-cell lymphoma 421.25 11.04 229 134625 6483 63347685
Epstein-Barr virus associated lymphoproliferative disorder 418.73 11.04 156 134698 1738 63352430
Escherichia infection 415.39 11.04 286 134568 12468 63341700
Graft versus host disease in gastrointestinal tract 398.22 11.04 175 134679 3066 63351102
Adenovirus infection 391.39 11.04 178 134676 3393 63350775
Chronic allograft nephropathy 390.77 11.04 117 134737 611 63353557
Drug hypersensitivity 383.92 11.04 94 134760 310593 63043575
Contraindicated product administered 365.07 11.04 25 134829 217623 63136545
Septic shock 359.35 11.04 565 134289 66064 63288104
Leukopenia 354.26 11.04 609 134245 76681 63277487
Dizziness 352.82 11.04 241 134613 429684 62924484
Mucormycosis 352.67 11.04 155 134699 2716 63351452
Pemphigus 351.69 11.04 8 134846 183718 63170450
Blood creatinine increased 351.14 11.04 652 134202 87192 63266976
Haemophagocytic lymphohistiocytosis 350.09 11.04 240 134614 10387 63343781
Enterococcal infection 346.47 11.04 213 134641 7635 63346533
Hypersensitivity 345.50 11.04 97 134757 292588 63061580
Swelling 344.72 11.04 81 134773 275297 63078871
Graft versus host disease in skin 344.48 11.04 153 134701 2752 63351416
Synovitis 343.59 11.04 12 134842 186906 63167262
Glossodynia 341.57 11.04 8 134846 178868 63175300
Infusion related reaction 339.12 11.04 57 134797 245464 63108704
Fall 331.21 11.04 213 134641 392121 62962047
Polyomavirus viraemia 326.05 11.04 102 134752 632 63353536
Dyspnoea 323.18 11.04 570 134284 660743 62693425
Acne 312.29 11.04 312 134542 22981 63331187
Abdominal discomfort 311.69 11.04 146 134708 320739 63033429
Haemolytic uraemic syndrome 310.27 11.04 136 134718 2367 63351801
Epstein-Barr viraemia 309.60 11.04 106 134748 904 63353264
Parvovirus B19 infection 305.24 11.04 91 134763 467 63353701
Aplasia pure red cell 303.75 11.04 161 134693 4326 63349842
Kidney fibrosis 302.58 11.04 123 134731 1758 63352410
Peripheral swelling 299.56 11.04 96 134758 265846 63088322
Post transplant distal limb syndrome 295.95 11.04 75 134779 178 63353990
Sepsis 290.91 11.04 848 134006 152275 63201893
Completed suicide 280.10 11.04 6 134848 145667 63208501
Bacteraemia 279.19 11.04 257 134597 17091 63337077
Respiratory failure 278.79 11.04 647 134207 101211 63252957
Phaeohyphomycosis 276.81 11.04 74 134780 233 63353935
JC virus infection 275.69 11.04 118 134736 1933 63352235
Pain in extremity 268.84 11.04 188 134666 331298 63022870
Nausea 268.77 11.04 926 133928 853545 62500623
Cytomegalovirus test positive 264.71 11.04 129 134725 2889 63351279
Wound 264.50 11.04 22 134832 163241 63190927
Pseudomonas infection 262.38 11.04 206 134648 11007 63343161
Human herpesvirus 6 infection 258.18 11.04 126 134728 2831 63351337
Graft loss 258.01 11.04 73 134781 300 63353868
Lung transplant rejection 256.00 11.04 90 134764 837 63353331
Renal tubular necrosis 247.73 11.04 204 134650 11674 63342494
Acute graft versus host disease in intestine 246.28 11.04 104 134750 1645 63352523
Headache 245.28 11.04 622 134232 632619 62721549
Heart transplant rejection 242.31 11.04 78 134776 537 63353631
Strongyloidiasis 240.55 11.04 93 134761 1155 63353013
Lymphoproliferative disorder 237.49 11.04 122 134732 3068 63351100
Therapeutic product effect decreased 235.44 11.04 60 134794 193127 63161041
Rash 233.69 11.04 530 134324 560341 62793827
Exposure during pregnancy 232.50 11.04 793 134061 154754 63199414
Human polyomavirus infection 225.63 11.04 64 134790 266 63353902
Malaise 223.78 11.04 336 134518 415618 62938550
Systemic lupus erythematosus 217.11 11.04 86 134768 208832 63145336
Lymphocele 213 11.04 76 134778 741 63353427
Focal segmental glomerulosclerosis 209.08 11.04 88 134766 1380 63352788
Malacoplakia 208.78 11.04 53 134801 127 63354041
Sinusitis 208.07 11.04 111 134743 226542 63127626
Venoocclusive liver disease 207.77 11.04 129 134725 4706 63349462
Pathogen resistance 207.21 11.04 143 134711 6255 63347913
Cystitis haemorrhagic 205.54 11.04 121 134733 4002 63350166
Systemic mycosis 205.40 11.04 82 134772 1115 63353053
Nasopharyngitis 204.97 11.04 145 134709 254112 63100056
Viraemia 201.27 11.04 83 134771 1233 63352935
Varicella zoster virus infection 200.65 11.04 103 134751 2586 63351582
Histoplasmosis disseminated 196.47 11.04 84 134770 1372 63352796
Chronic graft versus host disease in skin 196.14 11.04 70 134784 683 63353485
Diabetes mellitus 188.51 11.04 386 134468 55424 63298744
Renal failure 188.34 11.04 614 134240 117038 63237130
Atypical haemolytic uraemic syndrome 186.45 11.04 67 134787 668 63353500
Musculoskeletal stiffness 185.33 11.04 80 134774 184538 63169630
West Nile viral infection 183.46 11.04 57 134797 344 63353824
Acute respiratory distress syndrome 181.96 11.04 237 134617 23297 63330871
Renal transplant 180.89 11.04 78 134776 1302 63352866
Renal graft infection 179.98 11.04 51 134803 211 63353957
Proteinuria 178.83 11.04 212 134642 18933 63335235
Cytomegalovirus colitis 177.40 11.04 91 134763 2281 63351887
Pericarditis 174.08 11.04 34 134820 131545 63222623
Cryptococcosis 173.66 11.04 72 134782 1085 63353083
Pneumonia cytomegaloviral 171.58 11.04 87 134767 2127 63352041
Ureaplasma infection 171.39 11.04 61 134793 590 63353578
Back pain 170.22 11.04 186 134668 263959 63090209
Dermatitis atopic 170.11 11.04 151 134703 9573 63344595
Drug intolerance 170.08 11.04 245 134609 308416 63045752
Infection reactivation 167.84 11.04 71 134783 1128 63353040
Weight increased 165.46 11.04 186 134668 260606 63093562
Candida infection 164.80 11.04 249 134605 28102 63326066
Toxoplasmosis 164.02 11.04 75 134779 1448 63352720
Systemic candida 163.78 11.04 96 134758 3149 63351019
Pancytopenia 163.41 11.04 515 134339 96418 63257750
Anxiety 162.59 11.04 134 134720 217407 63136761
Pyelonephritis 161.35 11.04 194 134660 17584 63336584
Brain abscess 160.56 11.04 82 134772 2036 63352132
Discomfort 159.48 11.04 78 134776 167296 63186872
Pneumatosis intestinalis 158.87 11.04 85 134769 2328 63351840
Asthenia 158.25 11.04 364 134490 383240 62970928
Helicobacter infection 157.40 11.04 10 134844 92775 63261393
Pre-eclampsia 156.15 11.04 140 134714 8993 63345175
Mycobacterial infection 155.74 11.04 76 134778 1707 63352461
Hepatitis E 155.16 11.04 71 134783 1373 63352795
Pancreas transplant rejection 152.85 11.04 40 134814 113 63354055
Product dose omission issue 152.05 11.04 164 134690 234149 63120019
Herpes simplex 151.82 11.04 132 134722 8139 63346029
Contusion 150.60 11.04 65 134789 149979 63204189
Hypogammaglobulinaemia 149.44 11.04 123 134731 7032 63347136
Scedosporium infection 149.15 11.04 53 134801 510 63353658
Drug resistance 148.60 11.04 212 134642 22721 63331447
Constipation 147.56 11.04 156 134698 224787 63129381
Mobility decreased 146.84 11.04 38 134816 121121 63233047
Acute graft versus host disease in liver 143.71 11.04 54 134800 617 63353551
Pulmonary nocardiosis 143.61 11.04 46 134808 311 63353857
Lower respiratory tract infection 143.19 11.04 51 134803 132256 63221912
Drug level decreased 142.58 11.04 125 134729 7794 63346374
Progressive multifocal leukoencephalopathy 142.09 11.04 156 134698 12815 63341353
Complications of transplanted liver 141.90 11.04 47 134807 358 63353810
Epstein-Barr virus infection reactivation 141.58 11.04 56 134798 742 63353426
Fibromyalgia 141.55 11.04 7 134847 80413 63273755
Renal tubular atrophy 139.58 11.04 55 134799 721 63353447
Meningitis cryptococcal 139.51 11.04 65 134789 1312 63352856
Irritable bowel syndrome 139.44 11.04 9 134845 82403 63271765
Insomnia 138.16 11.04 152 134702 215100 63139068
End stage renal disease 137.58 11.04 114 134740 6579 63347589
Viral haemorrhagic cystitis 136.95 11.04 56 134798 813 63353355
Confusional state 135.78 11.04 182 134672 236198 63117970
Hepatic enzyme increased 135.31 11.04 138 134716 202190 63151978
Tubulointerstitial nephritis 131.92 11.04 186 134668 19717 63334451
Cytomegalovirus enteritis 131.61 11.04 41 134813 250 63353918
Hepatitis C 130.14 11.04 100 134754 5174 63348994
Infective aneurysm 129.57 11.04 44 134810 365 63353803
Haemolytic anaemia 129.06 11.04 132 134722 9993 63344175
Encephalitis viral 128.24 11.04 66 134788 1666 63352502
Nephrotic syndrome 127.35 11.04 101 134753 5475 63348693
Feeling abnormal 127.08 11.04 79 134775 148313 63205855
Somnolence 126.29 11.04 116 134738 178569 63175599
Syncope 125.74 11.04 46 134808 117339 63236829
Alternaria infection 124.67 11.04 38 134816 213 63353955
Psoriatic arthropathy 124.57 11.04 22 134832 91498 63262670
Drug ineffective for unapproved indication 123.86 11.04 243 134611 33820 63320348
Cryptosporidiosis infection 123.81 11.04 40 134814 279 63353889
Immune reconstitution inflammatory syndrome 123.75 11.04 103 134751 5981 63348187
Depression 123.63 11.04 141 134713 196351 63157817
Cholangitis 123.32 11.04 99 134755 5462 63348706
Acute myeloid leukaemia recurrent 120.61 11.04 62 134792 1561 63352607
Chest pain 120.27 11.04 170 134684 215789 63138379
Human herpesvirus 8 infection 119.41 11.04 37 134817 221 63353947
Toxicity to various agents 117.08 11.04 912 133942 246338 63107830
Escherichia bacteraemia 116.91 11.04 83 134771 3800 63350368
Pneumonia fungal 116.49 11.04 95 134759 5360 63348808
Rheumatoid arthritis 116.13 11.04 227 134627 253592 63100576
Locked-in syndrome 114.61 11.04 41 134813 403 63353765
Drug abuse 114.08 11.04 11 134843 72507 63281661
Urticaria 113.23 11.04 111 134743 165691 63188477
Abortion spontaneous 113.16 11.04 285 134569 46910 63307258
Shock haemorrhagic 111.86 11.04 121 134733 9774 63344394
Disease recurrence 111.81 11.04 208 134646 27822 63326346
Hypoaesthesia 111.27 11.04 116 134738 168277 63185891
Blastomycosis 111.24 11.04 37 134817 286 63353882
Obliterative bronchiolitis 111.09 11.04 64 134790 2031 63352137
Donor specific antibody present 110.77 11.04 32 134822 144 63354024
Intentional overdose 109.69 11.04 14 134840 74138 63280030
Muscle spasms 109.59 11.04 102 134752 156048 63198120
Asthma 109.10 11.04 68 134786 127493 63226675
Emphysematous pyelonephritis 108.59 11.04 35 134819 242 63353926
Blister 108.56 11.04 71 134783 129743 63224425
Escherichia urinary tract infection 107.67 11.04 130 134724 11832 63342336
Folliculitis 107.17 11.04 12 134842 70305 63283863
Staphylococcal infection 106.18 11.04 256 134598 41000 63313168
Hepatosplenic T-cell lymphoma 105.88 11.04 42 134812 561 63353607
Engraftment syndrome 105.60 11.04 40 134814 468 63353700
Chronic obstructive pulmonary disease 105.59 11.04 7 134847 62679 63291489
New onset diabetes after transplantation 105.26 11.04 28 134826 86 63354082
Chest discomfort 103.58 11.04 52 134802 109917 63244251
Mycobacterium abscessus infection 101.96 11.04 42 134812 622 63353546
Injection site pain 101.92 11.04 76 134778 129724 63224444
Liver abscess 100.05 11.04 67 134787 2787 63351381
Enterobacter infection 99.71 11.04 61 134793 2166 63352002
Gait disturbance 98.24 11.04 148 134706 183030 63171138
Wheezing 98.17 11.04 40 134814 95555 63258613
Glomerulonephritis 97.98 11.04 56 134798 1750 63352418
Complications of transplanted lung 97.39 11.04 32 134822 237 63353931
Impaired healing 97.32 11.04 48 134806 102494 63251674
Blood cholesterol increased 97.12 11.04 39 134815 93993 63260175
Neurotoxicity 97.00 11.04 148 134706 16842 63337326
Complications of transplant surgery 96.29 11.04 29 134825 155 63354013
Polyomavirus test positive 96.22 11.04 25 134829 68 63354100
Paraesthesia 96.17 11.04 115 134739 156851 63197317
Cytomegalovirus chorioretinitis 95.68 11.04 55 134799 1738 63352430
Vaccination failure 95.65 11.04 42 134812 734 63353434
Squamous cell carcinoma of skin 95.09 11.04 89 134765 6043 63348125
Graft complication 94.89 11.04 31 134823 225 63353943
Arthritis 94.77 11.04 65 134789 115856 63238312
Angiosarcoma 94.77 11.04 31 134823 226 63353942
Osteoarthritis 94.54 11.04 42 134812 95301 63258867
Knee arthroplasty 94.50 11.04 5 134849 54201 63299967
Hyperhidrosis 94.28 11.04 56 134798 107780 63246388
Musculoskeletal pain 94.13 11.04 39 134815 92238 63261930
Human ehrlichiosis 93.86 11.04 28 134826 144 63354024
Renal tubular injury 93.69 11.04 37 134817 488 63353680
Encephalopathy 93.40 11.04 234 134620 38386 63315782
Cytomegalovirus gastrointestinal infection 92.94 11.04 32 134822 278 63353890
Encapsulating peritoneal sclerosis 92.92 11.04 33 134821 317 63353851
Anti-erythropoietin antibody negative 92.06 11.04 26 134828 106 63354062
Pneumonia bacterial 92.03 11.04 107 134747 9358 63344810
Venoocclusive disease 91.20 11.04 56 134798 2002 63352166
Histoplasmosis 90.85 11.04 55 134799 1916 63352252
Weight decreased 90.50 11.04 294 134560 276504 63077664
Graft versus host disease in lung 90.10 11.04 33 134821 349 63353819
Papilloma viral infection 88.72 11.04 50 134804 1520 63352648
Balance disorder 87.21 11.04 35 134819 84387 63269781
Hyperammonaemia 87.08 11.04 79 134775 5153 63349015
Flushing 86.39 11.04 26 134828 75061 63279107
Mycobacterium avium complex infection 86.10 11.04 63 134791 3025 63351143
Heart rate increased 85.15 11.04 47 134807 94191 63259977
Rhodococcus infection 84.75 11.04 24 134830 99 63354069
Ascites 84.44 11.04 233 134621 40495 63313673
Cytomegalovirus enterocolitis 84.40 11.04 37 134817 644 63353524
Ill-defined disorder 84.28 11.04 34 134820 81721 63272447
Autoimmune haemolytic anaemia 83.58 11.04 73 134781 4528 63349640
Cerebral toxoplasmosis 83.37 11.04 41 134813 937 63353231
Memory impairment 83.20 11.04 60 134794 104198 63249970
Disseminated intravascular coagulation 83.14 11.04 147 134707 18904 63335264
COVID-19 pneumonia 82.85 11.04 125 134729 14084 63340084
Drug level above therapeutic 82.82 11.04 74 134780 4731 63349437
Infection in an immunocompromised host 82.03 11.04 37 134817 691 63353477
Chronic kidney disease 81.84 11.04 247 134607 45151 63309017
Oesophageal candidiasis 81.74 11.04 79 134775 5584 63348584
MELAS syndrome 81.51 11.04 24 134830 117 63354051
Bone marrow failure 81.07 11.04 187 134667 29103 63325065
Abdominal pain upper 80.92 11.04 201 134653 206243 63147925
Gastroenteritis norovirus 80.91 11.04 52 134802 2016 63352152
Epstein-Barr virus test positive 80.85 11.04 35 134819 590 63353578
Hepatic failure 79.97 11.04 210 134644 35446 63318722
Passenger lymphocyte syndrome 79.56 11.04 21 134833 62 63354106
Organising pneumonia 78.56 11.04 78 134776 5698 63348470
Dermatophytosis 78.31 11.04 25 134829 167 63354001
Microangiopathic haemolytic anaemia 77.70 11.04 34 134820 589 63353579
Visceral leishmaniasis 77.68 11.04 33 134821 530 63353638
Dry mouth 77.66 11.04 34 134820 77829 63276339
Alveolar proteinosis 76.81 11.04 29 134825 336 63353832
Drug level fluctuating 76.76 11.04 31 134823 435 63353733
Bacterial sepsis 76.37 11.04 65 134789 3893 63350275
Cerebral aspergillosis 76.22 11.04 30 134824 392 63353776
Acanthamoeba infection 76.22 11.04 19 134835 41 63354127
Leukoencephalopathy 76.14 11.04 68 134786 4345 63349823
Injection site erythema 75.85 11.04 41 134813 83133 63271035
Hip arthroplasty 75.54 11.04 7 134847 47639 63306529
Glomerulonephritis membranoproliferative 75.41 11.04 25 134829 191 63353977
Infectious pleural effusion 75.10 11.04 45 134809 1538 63352630
Clostridium difficile colitis 75.09 11.04 147 134707 20422 63333746
Urinary tract infection bacterial 74.96 11.04 72 134782 5050 63349118
Adverse event 74.87 11.04 25 134829 67534 63286634
Injury 74.63 11.04 31 134823 73216 63280952
Encephalitis cytomegalovirus 74.49 11.04 32 134822 529 63353639
SARS-CoV-2 RNA increased 74.33 11.04 20 134834 65 63354103
Babesiosis 73.98 11.04 25 134829 204 63353964
Mycoplasma infection 73.83 11.04 31 134823 483 63353685
Decreased appetite 73.76 11.04 279 134575 250773 63103395
Chronic myeloid leukaemia 73.16 11.04 51 134803 2267 63351901
Squamous cell carcinoma 73.14 11.04 91 134763 8541 63345627
Premature baby 73.06 11.04 146 134708 20589 63333579
Transplantation associated food allergy 73.02 11.04 16 134838 13 63354155
Graft versus host disease in liver 72.79 11.04 33 134821 624 63353544
Hydronephrosis 72.68 11.04 101 134753 10561 63343607
Nephropathy 72.48 11.04 78 134776 6263 63347905
Palpitations 71.89 11.04 80 134774 112690 63241478
Disseminated cryptococcosis 71.87 11.04 29 134825 406 63353762
Glomerulosclerosis 70.38 11.04 28 134826 377 63353791
Klebsiella bacteraemia 70.15 11.04 44 134810 1634 63352534
Type 2 diabetes mellitus 70.14 11.04 24 134830 63844 63290324
Lung transplant 70.02 11.04 56 134798 3072 63351096
Brain oedema 69.13 11.04 115 134739 14080 63340088
Splenic abscess 68.90 11.04 22 134832 147 63354021
Intestine transplant rejection 68.73 11.04 17 134837 35 63354133
Chronic graft versus host disease in liver 68.37 11.04 25 134829 263 63353905
Cough 68.09 11.04 355 134499 292388 63061780
Ureteric stenosis 67.72 11.04 31 134823 600 63353568
Prophylaxis against transplant rejection 67.49 11.04 15 134839 14 63354154
Bacterial infection 67.15 11.04 136 134718 19363 63334805
Vomiting 66.99 11.04 814 134040 558803 62795365
Angiosarcoma metastatic 66.78 11.04 18 134836 59 63354109
Coccidioidomycosis 66.41 11.04 35 134819 929 63353239
Pleural mesothelioma malignant 66.32 11.04 17 134837 43 63354125
Disseminated aspergillosis 65.86 11.04 19 134835 85 63354083
IgA nephropathy 65.80 11.04 30 134824 575 63353593
General physical health deterioration 65.73 11.04 214 134640 201188 63152980
Blood pressure increased 65.69 11.04 155 134699 161907 63192261
Hepatic artery thrombosis 65.66 11.04 18 134836 64 63354104
Influenza like illness 65.36 11.04 30 134824 66794 63287374
Liver function test abnormal 65.28 11.04 238 134616 47943 63306225
Enterocolitis 65.24 11.04 82 134772 7776 63346392
Disseminated mycobacterium avium complex infection 65.19 11.04 20 134834 115 63354053
Bacillary angiomatosis 64.98 11.04 19 134835 90 63354078
Fungal infection 64.94 11.04 199 134655 36675 63317493
Cleft palate 64.81 11.04 35 134819 977 63353191
Dysplasia 64.73 11.04 34 134820 896 63353272
Malignant neoplasm progression 64.55 11.04 48 134806 82073 63272095
Thrombotic thrombocytopenic purpura 63.99 11.04 58 134796 3778 63350390
Malacoplakia gastrointestinal 63.96 11.04 17 134837 52 63354116
Proteus infection 63.95 11.04 36 134818 1092 63353076
Microtia 63.74 11.04 26 134828 375 63353793
Anogenital warts 63.57 11.04 28 134826 493 63353675
Trichophytosis 63.48 11.04 17 134837 54 63354114
Low birth weight baby 63.38 11.04 77 134777 7052 63347116
Peritonitis 63.11 11.04 123 134731 17031 63337137
Stenotrophomonas infection 62.58 11.04 44 134810 1983 63352185
Hepatitis B 62.35 11.04 57 134797 3755 63350413
Lymphopenia 62.13 11.04 127 134727 18200 63335968
Cat scratch disease 62.07 11.04 22 134832 210 63353958
Encephalitis 61.85 11.04 85 134769 8795 63345373
Oesophageal stenosis 61.72 11.04 53 134801 3213 63350955
Epidermodysplasia verruciformis 61.39 11.04 19 134835 113 63354055
Pulmonary mucormycosis 61.29 11.04 24 134830 309 63353859
Pruritus 60.74 11.04 484 134370 360969 62993199
Disseminated toxoplasmosis 60.56 11.04 19 134835 119 63354049
Epstein-Barr virus associated lymphoma 60.51 11.04 27 134827 491 63353677
Adenoviral hepatitis 60.34 11.04 25 134829 376 63353792
Renal artery stenosis 60.25 11.04 42 134812 1867 63352301
Complications of transplanted heart 60.18 11.04 16 134838 49 63354119
Osmotic demyelination syndrome 60.14 11.04 29 134825 634 63353534
Cerebrovascular accident 60.12 11.04 85 134769 107939 63246229
Bacterial pyelonephritis 60.00 11.04 24 134830 328 63353840
Renal tubular acidosis 59.99 11.04 40 134814 1652 63352516
Haemodialysis 59.86 11.04 84 134770 8863 63345305
Escherichia sepsis 59.72 11.04 63 134791 4944 63349224
Malacoplakia vesicae 59.70 11.04 16 134838 51 63354117
Therapeutic product effect incomplete 59.63 11.04 109 134745 124947 63229221
Citrobacter infection 59.60 11.04 26 134828 447 63353721
Periostitis 59.48 11.04 24 134830 336 63353832
Urinary tract infection 59.38 11.04 839 134015 263845 63090323
Central nervous system viral infection 59.34 11.04 18 134836 99 63354069
Disseminated tuberculosis 59.27 11.04 49 134805 2818 63351350
Cytomegalovirus hepatitis 59.10 11.04 24 134830 342 63353826
C-reactive protein abnormal 58.69 11.04 13 134841 46083 63308085
Device expulsion 58.51 11.04 4 134850 34918 63319250
Pyelonephritis acute 58.23 11.04 60 134794 4581 63349587
Hyperuricaemia 57.80 11.04 64 134790 5306 63348862
Adenoviral haemorrhagic cystitis 57.45 11.04 19 134835 144 63354024
Clostridial infection 57.32 11.04 58 134796 4334 63349834
Loss of consciousness 57.17 11.04 102 134752 118019 63236149
Human herpesvirus 6 encephalitis 57.01 11.04 21 134833 226 63353942
Actinic keratosis 56.98 11.04 46 134808 2558 63351610
Skin papilloma 56.58 11.04 61 134793 4908 63349260
Dyspepsia 56.29 11.04 81 134773 102115 63252053
Nodular melanoma 56.16 11.04 15 134839 47 63354121
Pulmonary alveolar haemorrhage 56.15 11.04 59 134795 4609 63349559
Injection site reaction 56.12 11.04 27 134827 58497 63295671
Bradycardia 56.03 11.04 44 134810 73183 63280985
Pain in jaw 55.92 11.04 12 134842 43484 63310684
Upper respiratory fungal infection 55.80 11.04 19 134835 159 63354009
Limb reduction defect 55.58 11.04 24 134830 402 63353766
Vertigo 55.36 11.04 29 134825 59858 63294310
Renal abscess 55.32 11.04 29 134825 761 63353407
Neck pain 55.15 11.04 40 134814 69278 63284890
Biliary anastomosis complication 55.02 11.04 14 134840 34 63354134
Wrong technique in product usage process 55.01 11.04 32 134822 62308 63291860
Cytomegalovirus gastritis 54.49 11.04 19 134835 172 63353996
Myalgia 54.07 11.04 147 134707 146382 63207786
Toxic encephalopathy 53.58 11.04 68 134786 6511 63347657
Hyperglycaemia 53.53 11.04 203 134651 41664 63312504
Pancreatitis haemorrhagic 53.50 11.04 25 134829 508 63353660
Dysmorphism 53.32 11.04 42 134812 2254 63351914
Myocardial infarction 53.24 11.04 81 134773 99812 63254356
Cardiac failure congestive 53.18 11.04 71 134783 92362 63261806
Treatment failure 52.90 11.04 230 134624 198813 63155355
Parainfluenzae virus infection 52.82 11.04 42 134812 2285 63351883
Oesophageal ulcer 52.68 11.04 56 134798 4434 63349734
Brain herniation 52.51 11.04 51 134803 3626 63350542
Neutropenia 52.17 11.04 585 134269 174420 63179748
Guillain-Barre syndrome 51.89 11.04 52 134802 3841 63350327
Hot flush 51.55 11.04 22 134832 51137 63303031
Lupus nephritis 51.48 11.04 45 134809 2794 63351374
BK polyomavirus test positive 51.46 11.04 14 134840 48 63354120
Suicide attempt 51.34 11.04 33 134821 60885 63293283
Liver transplant 51.25 11.04 41 134813 2250 63351918
Pneumomediastinum 51.03 11.04 34 134820 1402 63352766
Red blood cell sedimentation rate increased 51.01 11.04 15 134839 43967 63310201
Staphylococcal sepsis 50.98 11.04 74 134780 8054 63346114
Reticulocytopenia 50.97 11.04 15 134839 73 63354095
Subarachnoid haemorrhage 50.83 11.04 101 134753 14182 63339986
Neuropathy peripheral 50.76 11.04 103 134751 113564 63240604
Chronic graft versus host disease oral 50.71 11.04 17 134837 135 63354033
Dysgeusia 50.52 11.04 18 134836 46692 63307476
Pleural effusion 50.37 11.04 355 134499 92855 63261313
Heart rate decreased 50.23 11.04 17 134837 45543 63308625
Migraine 50.23 11.04 89 134765 103257 63250911
Encephalitis autoimmune 49.98 11.04 34 134820 1452 63352716
Splenomegaly 49.86 11.04 87 134767 11070 63343098
Microsporidia infection 49.76 11.04 20 134834 277 63353891
Philadelphia positive chronic myeloid leukaemia 49.60 11.04 13 134841 37 63354131
Fungal skin infection 49.60 11.04 55 134799 4567 63349601
Thrombocytopenia 49.55 11.04 515 134339 150642 63203526
Genital herpes simplex 49.50 11.04 20 134834 281 63353887
Pseudomonal bacteraemia 49.48 11.04 35 134819 1593 63352575
Neutrophil Pelger-Huet anomaly present 49.37 11.04 15 134839 83 63354085
Graft thrombosis 49.34 11.04 17 134837 148 63354020
Pneumonia klebsiella 49.30 11.04 41 134813 2378 63351790
Hyperglycaemic hyperosmolar nonketotic syndrome 49.23 11.04 29 134825 960 63353208
Central nervous system fungal infection 49.23 11.04 16 134838 114 63354054
Stomatitis 49.09 11.04 142 134712 138583 63215585
Cytomegalovirus gastroenteritis 49.01 11.04 18 134836 192 63353976
Optic neuropathy 48.98 11.04 38 134816 1994 63352174
Anuria 48.63 11.04 92 134762 12459 63341709
Hypotension 48.60 11.04 359 134495 272245 63081923
Penicillium infection 48.52 11.04 16 134838 120 63354048
Delayed engraftment 48.29 11.04 16 134838 122 63354046
Sarcoma of skin 48.10 11.04 12 134842 26 63354142
Epstein Barr virus positive mucocutaneous ulcer 48.10 11.04 22 134832 425 63353743
Anorexia nervosa 48.08 11.04 19 134835 251 63353917
Acinetobacter infection 48.03 11.04 34 134820 1549 63352619
Metastatic squamous cell carcinoma 48.02 11.04 19 134835 252 63353916
Haemorrhage intracranial 47.89 11.04 95 134759 13324 63340844
Renal tubular disorder 47.61 11.04 42 134812 2640 63351528
Sedation 47.33 11.04 12 134842 38797 63315371
Gestational hypertension 47.26 11.04 40 134814 2377 63351791
Chromoblastomycosis 47.20 11.04 12 134842 29 63354139
Dysphonia 47.15 11.04 21 134833 47593 63306575
Hepatic necrosis 46.66 11.04 59 134795 5628 63348540
Blood pressure fluctuation 46.54 11.04 20 134834 46297 63307871
Calciphylaxis 46.51 11.04 44 134810 3028 63351140
Illness 46.48 11.04 23 134831 49036 63305132
Renal necrosis 46.42 11.04 13 134841 51 63354117
Herpes simplex hepatitis 46.32 11.04 21 134833 397 63353771
Adverse drug reaction 46.09 11.04 61 134793 79653 63274515
Perinephric collection 45.90 11.04 15 134839 109 63354059
Feeling hot 45.64 11.04 25 134829 50329 63303839
Haemodynamic instability 45.49 11.04 75 134779 9115 63345053
Perinephric abscess 45.42 11.04 17 134837 192 63353976
Pneumocystis jirovecii infection 45.32 11.04 32 134822 1452 63352716
Throat irritation 45.22 11.04 12 134842 37635 63316533
Urinary tract infection viral 45.09 11.04 13 134841 58 63354110
Candida sepsis 45.05 11.04 31 134823 1349 63352819
Hepatic function abnormal 44.96 11.04 177 134677 36965 63317203
Disseminated cytomegaloviral infection 44.72 11.04 17 134837 201 63353967
Vascular hyalinosis 44.69 11.04 11 134843 22 63354146
Rash pruritic 44.41 11.04 37 134817 59762 63294406
Orf 44.36 11.04 11 134843 23 63354145
Oxygen saturation decreased 44.22 11.04 75 134779 88510 63265658
Drug reaction with eosinophilia and systemic symptoms 44.19 11.04 9 134845 33827 63320341
Pneumonia cryptococcal 44.01 11.04 25 134829 772 63353396
Complications of bone marrow transplant 43.93 11.04 21 134833 450 63353718
Injection site bruising 43.89 11.04 17 134837 41893 63312275
Atypical mycobacterial infection 43.88 11.04 28 134826 1072 63353096
Joint stiffness 43.82 11.04 17 134837 41852 63312316
Interstitial lung disease 43.46 11.04 252 134602 61656 63292512
Hypertrophic cardiomyopathy 43.39 11.04 32 134822 1555 63352613
Pyelonephritis fungal 43.29 11.04 15 134839 133 63354035
Disseminated mucormycosis 43.28 11.04 16 134838 174 63353994
Gastrooesophageal reflux disease 43.27 11.04 86 134768 95553 63258615
Haemolysis 43.00 11.04 62 134792 6706 63347462
Ureteral necrosis 42.87 11.04 12 134842 47 63354121
Bile duct stenosis 42.87 11.04 29 134825 1227 63352941
Bone pain 42.86 11.04 32 134822 54609 63299559
Oedema peripheral 42.80 11.04 232 134622 189279 63164889
Prescribed overdose 42.74 11.04 10 134844 34143 63320025
Coronavirus infection 42.66 11.04 49 134805 4229 63349939
Stress 42.41 11.04 48 134806 67119 63287049
Therapy partial responder 42.39 11.04 79 134775 10579 63343589
Bursitis 42.29 11.04 13 134841 37028 63317140
Respiratory distress 42.07 11.04 163 134691 33788 63320380
Urinary fistula 42.05 11.04 10 134844 16 63354152
Reversible cerebral vasoconstriction syndrome 42.02 11.04 39 134815 2619 63351549
Swollen tongue 41.98 11.04 11 134843 34789 63319379
Normocytic anaemia 41.88 11.04 34 134820 1906 63352262
Tremor 41.67 11.04 447 134407 131792 63222376
Staphylococcal bacteraemia 41.66 11.04 55 134799 5475 63348693
Eczema herpeticum 41.35 11.04 15 134839 154 63354014
Liver transplant failure 41.31 11.04 10 134844 18 63354150
Muscular weakness 41.30 11.04 128 134726 122225 63231943
Enterococcal bacteraemia 41.21 11.04 30 134824 1429 63352739
Inappropriate schedule of product administration 40.87 11.04 101 134753 103864 63250304
Drug level below therapeutic 40.75 11.04 51 134803 4815 63349353
Vesicoureteric reflux 40.72 11.04 16 134838 208 63353960
Chronic graft versus host disease in intestine 40.70 11.04 13 134841 87 63354081
Central nervous system lymphoma 40.43 11.04 30 134824 1472 63352696
Cytopenia 40.05 11.04 81 134773 11520 63342648
Aspergillus test positive 40.01 11.04 18 134836 334 63353834
Skin mass 39.97 11.04 56 134798 5899 63348269
Respiratory syncytial virus infection 39.87 11.04 61 134793 6957 63347211
Pneumonia pseudomonal 39.73 11.04 37 134817 2496 63351672
Blood potassium decreased 39.37 11.04 20 134834 42006 63312162
Engraft failure 39.34 11.04 18 134836 348 63353820
Lactic acidosis 39.33 11.04 16 134838 38271 63315897
Hepatic cyst infection 39.25 11.04 13 134841 99 63354069
Post procedural bile leak 39.19 11.04 14 134840 137 63354031
Renal disorder 38.99 11.04 156 134698 32818 63321350
Osteonecrosis of jaw 38.90 11.04 13 134841 35110 63319058
Pulmonary haemorrhage 38.81 11.04 61 134793 7120 63347048
Meningoencephalitis herpetic 38.79 11.04 27 134827 1197 63352971
Pregnancy 38.65 11.04 168 134686 36668 63317500
Dialysis 38.64 11.04 75 134779 10352 63343816
Hepatic fibrosis 38.40 11.04 43 134811 3609 63350559
Meningitis bacterial 38.36 11.04 28 134826 1339 63352829
Gastroenteritis eosinophilic 38.26 11.04 13 134841 108 63354060
Angiocentric lymphoma 38.13 11.04 21 134833 610 63353558
Rectal haemorrhage 38.09 11.04 29 134825 49001 63305167
Pancreas transplant 38.00 11.04 9 134845 14 63354154
Fungal sepsis 37.89 11.04 27 134827 1243 63352925
Opportunistic infection 37.87 11.04 32 134822 1897 63352271
Oesophageal atresia 37.80 11.04 20 134834 535 63353633
Tooth disorder 37.80 11.04 7 134847 28150 63326018
Hypertrophic osteoarthropathy 37.77 11.04 10 134844 30 63354138
Serum sickness 37.75 11.04 38 134816 2822 63351346
Renal vein thrombosis 37.73 11.04 18 134836 384 63353784
Hepatitis viral 37.71 11.04 19 134835 458 63353710
Device dislocation 37.66 11.04 5 134849 25700 63328468
Urate nephropathy 37.65 11.04 13 134841 114 63354054
Orthostatic hypotension 37.32 11.04 15 134839 36145 63318023
Foot deformity 37.23 11.04 7 134847 27846 63326322
Central nervous system infection 37.19 11.04 22 134832 734 63353434
Nasal congestion 37.19 11.04 51 134803 65609 63288559
Rhinovirus infection 37.18 11.04 47 134807 4482 63349686
Pneumonia influenzal 37.18 11.04 30 134824 1667 63352501
Campylobacter infection 37.10 11.04 25 134829 1051 63353117
Speech disorder 37.07 11.04 20 134834 40609 63313559
Post procedural urine leak 37.05 11.04 10 134844 33 63354135
Obesity 37.03 11.04 9 134845 29943 63324225
Aplastic anaemia 36.90 11.04 70 134784 9499 63344669
Trichosporon infection 36.63 11.04 16 134838 276 63353892
Bronchitis 36.54 11.04 139 134715 124796 63229372
Abdominal wall infection 36.51 11.04 12 134842 89 63354079
Hyperkalaemia 36.35 11.04 218 134636 53985 63300183
Cytomegalovirus urinary tract infection 36.34 11.04 11 134843 60 63354108
Genital herpes 36.34 11.04 30 134824 1722 63352446
Joint injury 36.34 11.04 9 134845 29563 63324605
Congenital nail disorder 36.16 11.04 12 134842 92 63354076
Azotaemia 36.08 11.04 46 134808 4425 63349743
Fungal endocarditis 36.06 11.04 15 134839 228 63353940
Cerebral microhaemorrhage 36.05 11.04 13 134841 131 63354037
Tuberculosis gastrointestinal 35.92 11.04 17 134837 356 63353812
Lymphocytic infiltration 35.89 11.04 23 134831 887 63353281
Urinary tract infection enterococcal 35.72 11.04 36 134818 2677 63351491
Agranulocytosis 35.61 11.04 126 134728 25008 63329160
Urosepsis 35.48 11.04 103 134751 18421 63335747
Moyamoya disease 35.46 11.04 11 134843 66 63354102
Oropharyngeal pain 35.44 11.04 94 134760 94393 63259775
Pericardial effusion 35.38 11.04 142 134712 29916 63324252
Steroid withdrawal syndrome 35.32 11.04 19 134835 526 63353642
External auditory canal atresia 35.32 11.04 11 134843 67 63354101
Steroid diabetes 34.92 11.04 26 134828 1282 63352886
Amnesia 34.79 11.04 40 134814 55545 63298623
Disseminated blastomycosis 34.77 11.04 9 134845 24 63354144
Hypokalaemia 34.74 11.04 109 134745 103695 63250473
Full blood count abnormal 34.68 11.04 12 134842 31705 63322463
Cystitis viral 34.64 11.04 13 134841 148 63354020
Injection site swelling 34.63 11.04 30 134824 47542 63306626
American trypanosomiasis 34.26 11.04 11 134843 75 63354093
Hepatic artery stenosis 34.24 11.04 9 134845 26 63354142
Kaposi's sarcoma 34.10 11.04 13 134841 155 63354013
Chronic graft versus host disease in eye 34.00 11.04 12 134842 113 63354055
Drug withdrawal syndrome 33.96 11.04 8 134846 27186 63326982
Device issue 33.96 11.04 5 134849 23776 63330392
Nephrogenic systemic fibrosis 33.84 11.04 45 134809 4511 63349657
Eosinophilic oesophagitis 33.81 11.04 16 134838 335 63353833
Leiomyosarcoma 33.76 11.04 14 134840 211 63353957
Urinary tract candidiasis 33.76 11.04 19 134835 576 63353592
Enterovirus infection 33.63 11.04 23 134831 991 63353177
Coagulation test abnormal 33.55 11.04 21 134833 777 63353391
Road traffic accident 33.47 11.04 18 134836 36614 63317554
Grip strength decreased 33.46 11.04 4 134850 22283 63331885
Gait inability 33.27 11.04 38 134816 52921 63301247
Diffuse alveolar damage 33.24 11.04 22 134832 897 63353271
B-cell lymphoma 33.20 11.04 38 134816 3267 63350901
Ear infection 33.17 11.04 20 134834 38193 63315975
Crying 33.12 11.04 5 134849 23338 63330830
Anaphylactic reaction 32.95 11.04 56 134798 66044 63288124
Subcapsular renal haematoma 32.92 11.04 15 134839 287 63353881
Suicidal ideation 32.89 11.04 51 134803 62370 63291798
Macular degeneration 32.85 11.04 6 134848 24370 63329798
Human herpesvirus 6 infection reactivation 32.84 11.04 16 134838 358 63353810
Chronic hepatitis C 32.68 11.04 13 134841 175 63353993
Premature labour 32.60 11.04 78 134776 12426 63341742
Clostridium difficile infection 32.57 11.04 138 134716 29784 63324384
Gastrointestinal lymphoma 32.52 11.04 10 134844 58 63354110
Muscle spasticity 32.50 11.04 4 134850 21790 63332378
Cytomegalovirus nephritis 32.50 11.04 8 134846 16 63354152
Klebsiella sepsis 32.47 11.04 26 134828 1429 63352739
Superinfection bacterial 32.39 11.04 19 134835 624 63353544
Epistaxis 32.38 11.04 66 134788 72659 63281509
Upper respiratory tract inflammation 32.35 11.04 33 134821 2490 63351678
Subcutaneous abscess 32.30 11.04 49 134805 5547 63348621
Neuropsychiatric lupus 32.22 11.04 13 134841 182 63353986
Blood pressure systolic increased 32.01 11.04 32 134822 47365 63306803
Apoptosis 32.00 11.04 11 134843 95 63354073
Cognitive disorder 31.97 11.04 43 134811 55772 63298396
Cerebral fungal infection 31.90 11.04 11 134843 96 63354072
Porokeratosis 31.86 11.04 12 134842 138 63354030
Vascular graft complication 31.81 11.04 9 134845 37 63354131
Night sweats 31.79 11.04 34 134820 48780 63305388
Norovirus infection 31.66 11.04 19 134835 651 63353517
Glomerulonephritis rapidly progressive 31.66 11.04 22 134832 973 63353195
Nephrectomy 31.65 11.04 26 134828 1482 63352686
Intervertebral disc protrusion 31.60 11.04 6 134848 23703 63330465
Humoral immune defect 31.56 11.04 14 134840 251 63353917
Hydrocephalus 31.43 11.04 47 134807 5253 63348915
Soft tissue sarcoma 31.41 11.04 12 134842 144 63354024
Infective scleritis 31.27 11.04 8 134846 20 63354148
Presyncope 31.27 11.04 10 134844 27775 63326393
Orthobunyavirus test positive 31.26 11.04 7 134847 7 63354161
Graft ischaemia 31.24 11.04 9 134845 40 63354128
Limb discomfort 31.21 11.04 12 134842 29704 63324464
Portal vein thrombosis 31.20 11.04 33 134821 2597 63351571
Evans syndrome 31.17 11.04 13 134841 199 63353969
Sciatica 31.17 11.04 17 134837 34307 63319861
Disseminated trichosporonosis 31.04 11.04 10 134844 69 63354099
Injection site pruritus 31.00 11.04 30 134824 45086 63309082
Normal newborn 30.91 11.04 60 134794 8281 63345887
Gastroenteritis 30.80 11.04 125 134729 26465 63327703
Immunosuppressant drug level 30.78 11.04 7 134847 8 63354160
Transplant abscess 30.78 11.04 7 134847 8 63354160
Oliguria 30.77 11.04 63 134791 9038 63345130
Oedematous kidney 30.67 11.04 11 134843 109 63354059
Diaphragmatic hernia 30.66 11.04 16 134838 416 63353752
Nosocomial infection 30.65 11.04 27 134827 1694 63352474
Necrotising fasciitis 30.61 11.04 35 134819 3006 63351162
Acid fast bacilli infection 30.56 11.04 10 134844 73 63354095
Adult T-cell lymphoma/leukaemia 30.42 11.04 13 134841 212 63353956
Agitation 30.37 11.04 50 134804 59707 63294461
Placenta accreta 30.37 11.04 13 134841 213 63353955
Large intestinal ulcer 30.29 11.04 37 134817 3407 63350761
Myopathy toxic 30.28 11.04 17 134837 513 63353655
Varicella 30.01 11.04 28 134826 1893 63352275
Cutaneous blastomycosis 29.91 11.04 7 134847 10 63354158
Urinary tract infection pseudomonal 29.84 11.04 20 134834 833 63353335
Disseminated varicella zoster vaccine virus infection 29.74 11.04 9 134845 49 63354119
Sebaceous carcinoma 29.73 11.04 8 134846 26 63354142
Treatment noncompliance 29.57 11.04 157 134697 37168 63317000
Pallor 29.46 11.04 14 134840 30554 63323614
Gastric ulcer 29.45 11.04 115 134739 23922 63330246
Squamous cell carcinoma of the vulva 29.28 11.04 8 134846 28 63354140
Endocarditis staphylococcal 29.20 11.04 15 134839 377 63353791
Cholestasis 29.18 11.04 132 134722 29302 63324866
Pulmonary fibrosis 29.11 11.04 25 134829 39784 63314384
Beta-N-acetyl-D-glucosaminidase increased 29.06 11.04 8 134846 29 63354139
Cervical dysplasia 29.04 11.04 35 134819 3179 63350989
Capillaritis 29.02 11.04 11 134843 129 63354039
Mycobacterium haemophilum infection 28.85 11.04 8 134846 30 63354138
Oedematous pancreatitis 28.82 11.04 17 134837 564 63353604
Swelling face 28.77 11.04 57 134797 63418 63290750
Endocarditis enterococcal 28.73 11.04 9 134845 56 63354112
Viral diarrhoea 28.69 11.04 12 134842 185 63353983
Endocarditis 28.56 11.04 47 134807 5703 63348465
Heart disease congenital 28.53 11.04 23 134831 1276 63352892
Depressed mood 28.47 11.04 26 134828 40165 63314003
Biloma 28.47 11.04 9 134845 58 63354110
Fluid retention 28.46 11.04 52 134802 59634 63294534
Fibromatosis colli of infancy 28.44 11.04 7 134847 14 63354154
Acquired plagiocephaly 28.44 11.04 7 134847 14 63354154
Mastitis bacterial 28.33 11.04 9 134845 59 63354109
Cytomegalovirus oesophagitis 28.24 11.04 13 134841 255 63353913
Adenovirus reactivation 28.21 11.04 11 134843 140 63354028
Histoplasmosis cutaneous 28.11 11.04 7 134847 15 63354153
Mycobacterium chelonae infection 28.11 11.04 16 134838 496 63353672
Hypoglycaemia 28.04 11.04 53 134801 60012 63294156
Limb hypoplasia congenital 28.01 11.04 12 134842 197 63353971
Musculoskeletal disorder 28.00 11.04 5 134849 20639 63333529
Escherichia pyelonephritis 27.99 11.04 15 134839 412 63353756
Hypoalbuminaemia 27.98 11.04 71 134783 11734 63342434
Morphoea 27.88 11.04 14 134840 335 63353833
Mediastinitis 27.84 11.04 12 134842 200 63353968
Blood pressure diastolic decreased 27.73 11.04 7 134847 22699 63331469
Neoplasm progression 27.72 11.04 22 134832 36406 63317762
Fluorosis 27.59 11.04 9 134845 65 63354103
Blood albumin increased 27.54 11.04 20 134834 949 63353219
Congenital diaphragmatic hernia 27.52 11.04 12 134842 206 63353962
Skin graft rejection 27.51 11.04 7 134847 17 63354151
Renal ischaemia 27.48 11.04 17 134837 616 63353552
Hepatitis cholestatic 27.37 11.04 51 134803 6827 63347341
Plasmablastic lymphoma 27.36 11.04 12 134842 209 63353959
Conjunctival melanoma 27.31 11.04 6 134848 5 63354163
Atrial fibrillation 27.31 11.04 141 134713 116495 63237673
Caesarean section 27.31 11.04 89 134765 16943 63337225
Medication error 27.27 11.04 43 134811 52241 63301927
Accidental exposure to product 27.27 11.04 12 134842 27393 63326775
Cutaneous malacoplakia 27.22 11.04 7 134847 18 63354150
Toxic leukoencephalopathy 27.22 11.04 18 134836 733 63353435
Subcutaneous emphysema 27.21 11.04 19 134835 847 63353321
Granuloma 27.15 11.04 46 134808 5715 63348453
Renal artery thrombosis 27.11 11.04 10 134844 108 63354060
Blood beta-D-glucan increased 27.06 11.04 12 134842 215 63353953
Parvovirus infection 27.05 11.04 13 134841 282 63353886
Dysstasia 26.88 11.04 6 134848 21160 63333008
Pancreatitis necrotising 26.84 11.04 25 134829 1687 63352481
Pneumonia staphylococcal 26.71 11.04 32 134822 2888 63351280
Molluscum contagiosum 26.71 11.04 12 134842 222 63353946
Impaired work ability 26.58 11.04 3 134851 17472 63336696
Drug tolerance decreased 26.57 11.04 3 134851 17470 63336698
Stomatococcal infection 26.55 11.04 10 134844 115 63354053
Full blood count decreased 26.53 11.04 11 134843 26013 63328155
Alopecia 26.35 11.04 532 134322 337004 63017164
Histology abnormal 26.32 11.04 10 134844 118 63354050
Removal of renal transplant 26.32 11.04 6 134848 7 63354161
Acute hepatitis C 26.26 11.04 9 134845 77 63354091
Hip fracture 26.18 11.04 15 134839 29459 63324709
Necrosis 26.11 11.04 44 134810 5443 63348725
Transient ischaemic attack 26.06 11.04 25 134829 37728 63316440
Bacteriuria 26.05 11.04 20 134834 1033 63353135
Type 1 diabetes mellitus 25.98 11.04 36 134818 3754 63350414
Localised infection 25.95 11.04 16 134838 30194 63323974
Diabetic macroangiopathy 25.95 11.04 10 134844 123 63354045
Endophthalmitis 25.95 11.04 35 134819 3557 63350611
Intrauterine infection 25.88 11.04 10 134844 124 63354044
Rhesus antigen positive 25.88 11.04 10 134844 124 63354044
Hepatic artery aneurysm 25.87 11.04 6 134848 8 63354160
Vision blurred 25.77 11.04 104 134750 91820 63262348
Muir-Torre syndrome 25.73 11.04 7 134847 24 63354144
Lupus enteritis 25.65 11.04 8 134846 49 63354119
Myocardial necrosis 25.60 11.04 11 134843 182 63353986
Paraesthesia oral 25.40 11.04 5 134849 19251 63334917
Lymphadenopathy 25.35 11.04 154 134700 38304 63315864
Multiple sclerosis 25.33 11.04 10 134844 24362 63329806
Body temperature decreased 25.33 11.04 6 134848 20313 63333855
Scleroderma renal crisis 25.30 11.04 13 134841 327 63353841
Cutaneous nocardiosis 25.30 11.04 7 134847 26 63354142
Aspergillosis oral 25.24 11.04 8 134846 52 63354116
Distributive shock 25.24 11.04 22 134832 1361 63352807
Unevaluable event 25.19 11.04 44 134810 51342 63302826
Renal haematoma 25.17 11.04 11 134843 190 63353978
Enterocolitis viral 25.11 11.04 12 134842 257 63353911
Hair follicle tumour benign 25.10 11.04 14 134840 417 63353751
Systemic bacterial infection 25.08 11.04 6 134848 10 63354158
Cardiac tamponade 25.03 11.04 40 134814 4735 63349433
Eczema 25.02 11.04 135 134719 32156 63322012
Cutaneous leishmaniasis 25.02 11.04 9 134845 90 63354078
Bone marrow transplant 25.01 11.04 17 134837 725 63353443
Sopor 24.90 11.04 8 134846 22156 63332012
Pneumonia pneumococcal 24.88 11.04 27 134827 2188 63351980
Congenital oral malformation 24.86 11.04 11 134843 196 63353972
Lethargy 24.78 11.04 51 134803 55956 63298212
Erythema infectiosum 24.76 11.04 9 134845 93 63354075
Surgical procedure repeated 24.69 11.04 12 134842 267 63353901
Fusarium infection 24.67 11.04 16 134838 630 63353538
Idiopathic pneumonia syndrome 24.60 11.04 13 134841 347 63353821
Pericarditis constrictive 24.50 11.04 13 134841 350 63353818
Nervousness 24.48 11.04 18 134836 30961 63323207
Pneumoperitoneum 24.43 11.04 22 134832 1421 63352747
Food allergy 24.40 11.04 66 134788 11335 63342833
Underdose 24.35 11.04 14 134840 27442 63326726
Carpal tunnel syndrome 24.32 11.04 7 134847 20810 63333358
Fryns syndrome 24.15 11.04 8 134846 61 63354107
Pulmonary hypoplasia 24.13 11.04 12 134842 281 63353887
Eye infection toxoplasmal 24.06 11.04 12 134842 283 63353885
Biliary fistula 24.05 11.04 6 134848 13 63354155
Renal and pancreas transplant rejection 24.05 11.04 6 134848 13 63354155
Sinus disorder 24.04 11.04 11 134843 24542 63329626
Gastritis fungal 23.94 11.04 9 134845 103 63354065
Renal atrophy 23.92 11.04 22 134832 1460 63352708
Blood lactate dehydrogenase increased 23.92 11.04 105 134749 23011 63331157
Pulmonary tuberculosis 23.90 11.04 38 134816 4479 63349689
Avian influenza 23.81 11.04 8 134846 64 63354104
Abdominal distension 23.65 11.04 99 134755 86516 63267652
Graft versus host disease in eye 23.60 11.04 8 134846 66 63354102
Respiratory tract infection fungal 23.59 11.04 14 134840 470 63353698
Infective keratitis 23.47 11.04 7 134847 36 63354132
Hepatic angiosarcoma 23.46 11.04 6 134848 15 63354153
Perihepatic abscess 23.46 11.04 6 134848 15 63354153
Pancreatic leak 23.44 11.04 5 134849 3 63354165
Pelvic deformity 23.43 11.04 11 134843 226 63353942
Microangiopathy 23.35 11.04 20 134834 1208 63352960
Myelosuppression 23.28 11.04 106 134748 23597 63330571
Laryngitis 23.25 11.04 4 134850 16963 63337205
Intervertebral disc degeneration 23.19 11.04 3 134851 15729 63338439
Osteoporosis 23.08 11.04 55 134799 57283 63296885
Fungaemia 23.08 11.04 27 134827 2376 63351792
Cholelithiasis 23.03 11.04 36 134818 43889 63310279
Body temperature increased 23.02 11.04 27 134827 37165 63317003
Tinnitus 23.00 11.04 25 134829 35603 63318565
Feeling cold 22.93 11.04 11 134843 23877 63330291
Lacrimal gland enlargement 22.91 11.04 6 134848 17 63354151
Demodicidosis 22.85 11.04 5 134849 4 63354164
Orbital apex syndrome 22.85 11.04 7 134847 40 63354128
Device malfunction 22.80 11.04 5 134849 17852 63336316
Gastrointestinal disorder 22.80 11.04 174 134680 131065 63223103
Herpes simplex oesophagitis 22.76 11.04 10 134844 175 63353993
Respiratory tract congestion 22.76 11.04 5 134849 17827 63336341
Splenic vein thrombosis 22.75 11.04 12 134842 319 63353849
Arterioenteric fistula 22.66 11.04 6 134848 18 63354150
Gastroenteritis adenovirus 22.50 11.04 11 134843 248 63353920
Scleroderma 22.36 11.04 41 134813 5421 63348747
Procedural failure 22.33 11.04 5 134849 5 63354163
Granulicatella bacteraemia 22.33 11.04 5 134849 5 63354163
Meningitis 22.30 11.04 48 134806 7129 63347039
Disturbance in attention 22.30 11.04 29 134825 38160 63316008
Hiatus hernia 22.22 11.04 9 134845 21585 63332583
Arterial rupture 22.19 11.04 12 134842 336 63353832
Granulomatous rosacea 22.18 11.04 6 134848 20 63354148
Tendonitis 22.18 11.04 7 134847 19608 63334560
Septic embolus 22.11 11.04 17 134837 880 63353288
Acid base balance abnormal 22.11 11.04 11 134843 258 63353910
Acute respiratory failure 22.04 11.04 137 134717 34348 63319820
Gallbladder rupture 21.97 11.04 13 134841 434 63353734
Bone marrow granuloma 21.96 11.04 6 134848 21 63354147
Fat necrosis 21.96 11.04 15 134839 645 63353523
Erythema 21.94 11.04 253 134601 175498 63178670
Cardiac disorder 21.87 11.04 47 134807 50769 63303399
Skin squamous cell carcinoma recurrent 21.85 11.04 5 134849 6 63354162
Biliary tract infection fungal 21.85 11.04 5 134849 6 63354162
Dyspnoea exertional 21.85 11.04 61 134793 60241 63293927
Retrognathia 21.78 11.04 13 134841 441 63353727
Haemothorax 21.74 11.04 25 134829 2160 63352008
Peripheral T-cell lymphoma unspecified 21.73 11.04 10 134844 196 63353972
Drug specific antibody absent 21.64 11.04 8 134846 87 63354081
Cholangitis infective 21.62 11.04 12 134842 354 63353814
White blood cell count decreased 21.62 11.04 190 134664 138914 63215254
Transplant 21.61 11.04 16 134838 782 63353386
Red blood cell count decreased 21.61 11.04 33 134821 40612 63313556
Urine output decreased 21.56 11.04 63 134791 11307 63342861
Hepatic infarction 21.55 11.04 15 134839 665 63353503
Cerebral haemorrhage 21.51 11.04 125 134729 30604 63323564
Skin hypertrophy 21.45 11.04 31 134823 3360 63350808
Oral lichen planus 21.43 11.04 15 134839 671 63353497
Nephrocalcinosis 21.41 11.04 18 134836 1060 63353108
Osteonecrosis 21.40 11.04 106 134748 24424 63329744
Vascular pseudoaneurysm 21.39 11.04 21 134833 1513 63352655
Legionella infection 21.37 11.04 13 134841 457 63353711
Cutaneous T-cell lymphoma 21.34 11.04 20 134834 1360 63352808
Joint effusion 21.34 11.04 5 134849 17055 63337113
Focal myositis 21.33 11.04 6 134848 24 63354144
Transplantation complication 21.27 11.04 9 134845 143 63354025
Diverticulitis 21.14 11.04 32 134822 39525 63314643
Viral myelitis 21.14 11.04 6 134848 25 63354143
Seasonal allergy 21.12 11.04 9 134845 20941 63333227
Autoimmune hepatitis 21.03 11.04 52 134802 8458 63345710
Tracheo-oesophageal fistula 21.00 11.04 14 134840 578 63353590
Fear 20.99 11.04 4 134850 15762 63338406
Transaminases increased 20.93 11.04 126 134728 31241 63322927
Ileal ulcer 20.92 11.04 13 134841 475 63353693
Loss of personal independence in daily activities 20.91 11.04 121 134733 97169 63256999
Abdominal wound dehiscence 20.89 11.04 10 134844 215 63353953
Gallbladder disorder 20.82 11.04 7 134847 18835 63335333
Enterobacter pneumonia 20.77 11.04 6 134848 27 63354141
Lymphoma 20.74 11.04 65 134789 12122 63342046
Injection site haemorrhage 20.72 11.04 13 134841 24301 63329867
Chromaturia 20.71 11.04 5 134849 16712 63337456
Optic atrophy 20.69 11.04 19 134835 1259 63352909
Pleomorphism 20.65 11.04 5 134849 9 63354159
Fungal abscess central nervous system 20.65 11.04 5 134849 9 63354159
Drug level 20.63 11.04 4 134850 0 63354168
Neurocryptococcosis 20.63 11.04 4 134850 0 63354168
Biliary ischaemia 20.63 11.04 4 134850 0 63354168
Mycoplasma test positive 20.62 11.04 7 134847 58 63354110
Neurofibrosarcoma 20.62 11.04 9 134845 155 63354013
Lacrimation increased 20.58 11.04 9 134845 20622 63333546
Endothelial dysfunction 20.56 11.04 9 134845 156 63354012
Muscle twitching 20.56 11.04 8 134846 19660 63334508
Renal-limited thrombotic microangiopathy 20.52 11.04 7 134847 59 63354109
Injection site mass 20.50 11.04 7 134847 18649 63335519
Intussusception 20.45 11.04 14 134840 604 63353564
Milk allergy 20.39 11.04 10 134844 227 63353941
Panic attack 20.36 11.04 11 134843 22320 63331848
Herpes zoster 20.33 11.04 266 134588 82196 63271972
Chills 20.32 11.04 149 134705 113229 63240939
Necrotising retinitis 20.30 11.04 12 134842 400 63353768
Graft infection 20.25 11.04 9 134845 162 63354006
C-reactive protein increased 20.24 11.04 118 134736 94589 63259579
Bone disorder 20.20 11.04 10 134844 21316 63332852
Drug effective for unapproved indication 20.19 11.04 30 134824 3334 63350834
Acute myeloid leukaemia 20.17 11.04 81 134773 17066 63337102
Acidosis 20.13 11.04 61 134793 11172 63342996
Frequent bowel movements 20.05 11.04 12 134842 23010 63331158
Pseudallescheria infection 19.99 11.04 5 134849 11 63354157
Cholangitis acute 19.98 11.04 13 134841 515 63353653
Thyroid disorder 19.87 11.04 4 134850 15158 63339010
Malignant ascites 19.81 11.04 16 134838 890 63353278
Enteritis 19.81 11.04 50 134804 8236 63345932
Herpes simplex viraemia 19.80 11.04 11 134843 325 63353843
Encephalomyelitis 19.76 11.04 8 134846 113 63354055
Restlessness 19.76 11.04 20 134834 29433 63324735
Toothache 19.75 11.04 8 134846 19191 63334977
Colorectal cancer 19.75 11.04 31 134823 3614 63350554
Growth failure 19.71 11.04 11 134843 328 63353840
Photodermatosis 19.69 11.04 12 134842 423 63353745
Periportal oedema 19.69 11.04 5 134849 12 63354156
Viral myositis 19.69 11.04 5 134849 12 63354156
Cryptococcal cutaneous infection 19.64 11.04 7 134847 68 63354100
Electrocardiogram QT prolonged 19.57 11.04 63 134791 59467 63294701
Hepatic vein occlusion 19.55 11.04 7 134847 69 63354099
Hypervolaemia 19.51 11.04 115 134739 28298 63325870
Talipes 19.49 11.04 20 134834 1520 63352648
Tenosynovitis 19.47 11.04 3 134851 13792 63340376
Hypersomnia 19.45 11.04 7 134847 18048 63336120
Pterygium colli 19.41 11.04 5 134849 13 63354155
Ischaemic nephropathy 19.41 11.04 5 134849 13 63354155
Mucinous adenocarcinoma of appendix 19.41 11.04 5 134849 13 63354155
Moraxella infection 19.39 11.04 12 134842 435 63353733
Peliosis hepatis 19.37 11.04 7 134847 71 63354097
Tracheobronchitis 19.29 11.04 18 134836 1217 63352951
Liver injury 19.24 11.04 65 134789 60455 63293713
Cytotoxic oedema 19.21 11.04 9 134845 184 63353984
Lung infiltration 19.21 11.04 71 134783 14392 63339776
Hypertransaminasaemia 19.18 11.04 43 134811 6566 63347602
Coinfection 19.14 11.04 5 134849 14 63354154
Infusion site pain 19.11 11.04 6 134848 16863 63337305
Protein urine present 19.10 11.04 41 134813 6079 63348089
Bone marrow oedema 19.08 11.04 18 134836 1234 63352934
Ophthalmic herpes simplex 19.08 11.04 12 134842 448 63353720
Joint dislocation 19.07 11.04 8 134846 18792 63335376
Increased insulin requirement 19.03 11.04 7 134847 75 63354093
Aeromonas infection 19.03 11.04 7 134847 75 63354093
Leukaemic infiltration extramedullary 19.03 11.04 7 134847 75 63354093
Breast cancer 19.01 11.04 47 134807 48336 63305832
Urinary tract infection fungal 18.97 11.04 14 134840 681 63353487
Lymphoid tissue hyperplasia 18.95 11.04 9 134845 190 63353978
Diarrhoea infectious 18.93 11.04 17 134837 1094 63353074
Disseminated varicella zoster virus infection 18.92 11.04 10 134844 267 63353901
Biliary obstruction 18.91 11.04 27 134827 2894 63351274
Alpha haemolytic streptococcal infection 18.90 11.04 18 134836 1249 63352919
Serositis 18.90 11.04 14 134840 685 63353483
Sleep disorder 18.87 11.04 99 134755 81467 63272701
Tongue ulceration 18.87 11.04 30 134824 3536 63350632
Total cholesterol/HDL ratio abnormal 18.87 11.04 7 134847 77 63354091
Coombs positive haemolytic anaemia 18.79 11.04 11 134843 360 63353808
Blood test abnormal 18.74 11.04 5 134849 15624 63338544
Portal hypertension 18.68 11.04 31 134823 3788 63350380
Human herpesvirus 7 infection 18.64 11.04 8 134846 132 63354036
Torsade de pointes 18.62 11.04 3 134851 13348 63340820
Cachexia 18.61 11.04 39 134815 5687 63348481
Abdominal compartment syndrome 18.60 11.04 13 134841 580 63353588
Arteriovenous fistula occlusion 18.57 11.04 11 134843 368 63353800
Joint range of motion decreased 18.55 11.04 25 134829 32403 63321765
Meningoencephalitis bacterial 18.55 11.04 7 134847 81 63354087
Anastomotic complication 18.53 11.04 8 134846 134 63354034
Angina pectoris 18.44 11.04 22 134832 30056 63324112
Pneumonia herpes viral 18.43 11.04 6 134848 43 63354125
Meningomyelitis herpes 18.43 11.04 6 134848 43 63354125
Arteritis infective 18.43 11.04 6 134848 43 63354125
Stem cell transplant 18.39 11.04 21 134833 1801 63352367
Plasmapheresis 18.36 11.04 10 134844 284 63353884
Post herpetic neuralgia 18.34 11.04 23 134831 2176 63351992
Chylothorax 18.30 11.04 10 134844 286 63353882
Continuous haemodiafiltration 18.28 11.04 16 134838 995 63353173
Epileptic encephalopathy 18.26 11.04 10 134844 287 63353881
Encephalitis Japanese B 18.20 11.04 6 134848 45 63354123
Skin laceration 18.19 11.04 13 134841 22695 63331473
Gingival hypertrophy 18.13 11.04 20 134834 1651 63352517
Aggression 18.12 11.04 14 134840 23484 63330684
Haematuria 18.12 11.04 115 134739 29042 63325126
Pancreatitis acute 18.04 11.04 109 134745 27057 63327111
Delusional disorder, persecutory type 18.01 11.04 9 134845 213 63353955
Urinary incontinence 17.99 11.04 25 134829 31989 63322179
Herpes simplex pneumonia 17.98 11.04 5 134849 19 63354149
Injection site warmth 17.95 11.04 5 134849 15190 63338978
Head injury 17.93 11.04 19 134835 27377 63326791
Salmonellosis 17.88 11.04 17 134837 1177 63352991
Cholangiocarcinoma 17.88 11.04 17 134837 1177 63352991
Chronic hepatitis 17.87 11.04 15 134839 881 63353287
Fascioliasis 17.86 11.04 4 134850 4 63354164
Flavobacterium infection 17.86 11.04 4 134850 4 63354164
Acute allograft nephropathy 17.86 11.04 4 134850 4 63354164
Desmoplastic melanoma 17.86 11.04 4 134850 4 63354164
Immunosuppression 17.84 11.04 50 134804 8764 63345404
Blue toe syndrome 17.84 11.04 11 134843 396 63353772
Herpes zoster reactivation 17.82 11.04 7 134847 91 63354077
Squamous cell carcinoma of the oral cavity 17.80 11.04 10 134844 302 63353866
Blood calcium decreased 17.70 11.04 18 134836 26433 63327735
Chronic sinusitis 17.66 11.04 3 134851 12840 63341328
Achromobacter infection 17.64 11.04 6 134848 50 63354118
Renal injury 17.61 11.04 52 134802 9387 63344781
Arthritis reactive 17.57 11.04 11 134843 407 63353761
Pyelocaliectasis 17.52 11.04 13 134841 638 63353530
Fanconi syndrome 17.47 11.04 18 134836 1374 63352794
Shock 17.44 11.04 97 134757 23366 63330802
Purulent pericarditis 17.44 11.04 6 134848 52 63354116
Tonsillitis 17.42 11.04 38 134816 5697 63348471
Asterixis 17.40 11.04 18 134836 1381 63352787
Extranodal marginal zone B-cell lymphoma (MALT type) stage IV 17.39 11.04 4 134850 5 63354163
Product quality issue 17.32 11.04 31 134823 35834 63318334
Maternal exposure during pregnancy 17.31 11.04 600 134254 219462 63134706
Limbic encephalitis 17.25 11.04 10 134844 321 63353847
Transitional cell carcinoma 17.23 11.04 13 134841 654 63353514
Choriomeningitis lymphocytic 17.22 11.04 5 134849 23 63354145
Superinfection viral 17.22 11.04 5 134849 23 63354145
Mesothelioma malignant 17.14 11.04 6 134848 55 63354113
Pneumonia haemophilus 17.10 11.04 13 134841 662 63353506
Bacterial translocation 17.07 11.04 9 134845 239 63353929
Malnutrition 17.00 11.04 71 134783 15227 63338941
Nephrogenic diabetes insipidus 16.99 11.04 15 134839 944 63353224
Oropharyngeal candidiasis 16.99 11.04 16 134838 1095 63353073
Neutrophil count decreased 16.98 11.04 62 134792 56344 63297824
Epstein-Barr virus antibody positive 16.95 11.04 10 134844 332 63353836
Corynebacterium infection 16.95 11.04 12 134842 547 63353621
Skin induration 16.90 11.04 27 134827 3196 63350972
Acute motor axonal neuropathy 16.88 11.04 5 134849 25 63354143
Gastrointestinal necrosis 16.86 11.04 25 134829 2773 63351395
Pupil fixed 16.84 11.04 20 134834 1789 63352379
Pelvic pain 16.83 11.04 4 134850 13515 63340653
Biliary tract disorder 16.82 11.04 14 134840 813 63353355
Blood glucose decreased 16.78 11.04 12 134842 20940 63333228
Herpes simplex reactivation 16.77 11.04 12 134842 556 63353612
Asteatosis 16.77 11.04 6 134848 59 63354109
Diabetic ketoacidosis 16.76 11.04 87 134767 20418 63333750
Flatulence 16.75 11.04 30 134824 34672 63319496
Pseudomonal sepsis 16.75 11.04 23 134831 2378 63351790
Aspergilloma 16.74 11.04 9 134845 249 63353919
Japanese spotted fever 16.72 11.04 5 134849 26 63354142
Head discomfort 16.64 11.04 4 134850 13411 63340757
Pancreatic pseudocyst haemorrhage 16.60 11.04 4 134850 7 63354161
Hyperoxaluria 16.58 11.04 8 134846 175 63353993
Drug trough level 16.56 11.04 5 134849 27 63354141
Pleocytosis 16.55 11.04 14 134840 831 63353337
Respiratory tract infection viral 16.47 11.04 22 134832 2215 63351953
Periorbital cellulitis 16.46 11.04 13 134841 700 63353468
Hypertelorism 16.44 11.04 11 134843 457 63353711
Septal panniculitis 16.42 11.04 6 134848 63 63354105
Sinus congestion 16.42 11.04 9 134845 18114 63336054
Intracranial infection 16.41 11.04 5 134849 28 63354140
Catatonia 16.34 11.04 32 134822 4445 63349723
Glycosuria 16.33 11.04 16 134838 1150 63353018
Blood culture positive 16.27 11.04 33 134821 4702 63349466
Reperfusion injury 16.25 11.04 6 134848 65 63354103
Leukaemia recurrent 16.25 11.04 17 134837 1321 63352847
Parapox virus infection 16.25 11.04 4 134850 8 63354160
Polyhydramnios 16.21 11.04 22 134832 2249 63351919
Neuroleptic malignant syndrome 16.18 11.04 3 134851 12053 63342115
Thymus enlargement 16.17 11.04 7 134847 118 63354050
Cold sweat 16.16 11.04 3 134851 12044 63342124
Listeriosis 16.15 11.04 18 134836 1503 63352665
Toxic optic neuropathy 16.10 11.04 8 134846 187 63353981
Tooth infection 16.09 11.04 9 134845 17911 63336257
Femur fracture 16.07 11.04 41 134813 41715 63312453
Colon injury 16.06 11.04 8 134846 188 63353980
Dyslipidaemia 16.02 11.04 43 134811 7350 63346818
Haematochezia 16.02 11.04 59 134795 53485 63300683
Glomerulonephritis membranous 16.01 11.04 12 134842 598 63353570
Renal cortical necrosis 15.91 11.04 7 134847 123 63354045
Renal cyst infection 15.91 11.04 7 134847 123 63354045
Immune thrombocytopenia 15.89 11.04 54 134800 10502 63343666
Haematemesis 15.87 11.04 25 134829 30387 63323781
Adenocarcinoma 15.86 11.04 25 134829 2925 63351243
Throat cancer 15.85 11.04 12 134842 607 63353561
Skin weeping 15.84 11.04 13 134841 740 63353428
Emotional distress 15.83 11.04 28 134826 32521 63321647
Pneumonia respiratory syncytial viral 15.82 11.04 15 134839 1035 63353133
Acute motor-sensory axonal neuropathy 15.78 11.04 9 134845 280 63353888
Bacterial colitis 15.78 11.04 6 134848 71 63354097
Hyperparathyroidism 15.76 11.04 24 134830 2725 63351443
Lung adenocarcinoma 15.75 11.04 32 134822 4565 63349603
Potentiating drug interaction 15.74 11.04 31 134823 4325 63349843
Cerebral ventricle collapse 15.71 11.04 5 134849 33 63354135
Transient acantholytic dermatosis 15.70 11.04 6 134848 72 63354096
Metapneumovirus infection 15.70 11.04 15 134839 1045 63353123
Skin plaque 15.68 11.04 46 134808 8274 63345894
Unresponsive to stimuli 15.64 11.04 30 134824 33786 63320382
Leukaemia in remission 15.64 11.04 4 134850 10 63354158
Complications of intestinal transplant 15.64 11.04 4 134850 10 63354158
Intestinal pseudo-obstruction 15.63 11.04 14 134840 898 63353270
Cerebral mass effect 15.61 11.04 14 134840 899 63353269
Cleft lip and palate 15.58 11.04 12 134842 623 63353545
Respiratory tract infection bacterial 15.55 11.04 9 134845 288 63353880
Product complaint 15.54 11.04 4 134850 12805 63341363
Hypertensive encephalopathy 15.53 11.04 12 134842 626 63353542
Oropharyngeal lymphoid hyperplasia 15.47 11.04 3 134851 0 63354168
Disseminated paracoccidioidomycosis 15.47 11.04 3 134851 0 63354168
Sarcoma metastatic 15.47 11.04 3 134851 0 63354168
Multiple organ transplant rejection 15.47 11.04 3 134851 0 63354168
Complications of transplanted pancreas 15.47 11.04 3 134851 0 63354168
Mesenteric fibrosis 15.47 11.04 3 134851 0 63354168
Jejunal ulcer perforation 15.46 11.04 5 134849 35 63354133
Enterococcal sepsis 15.43 11.04 17 134837 1401 63352767
Clostridial sepsis 15.37 11.04 11 134843 510 63353658
Blood iron decreased 15.37 11.04 6 134848 14715 63339453
Acute pulmonary histoplasmosis 15.36 11.04 7 134847 134 63354034
Craniofacial deformity 15.36 11.04 7 134847 134 63354034
Pulmonary embolism 15.33 11.04 166 134688 116518 63237650
Bronchiolitis obliterans syndrome 15.31 11.04 7 134847 135 63354033
Intestinal perforation 15.28 11.04 58 134796 11905 63342263
Pancreatic pseudoaneurysm 15.27 11.04 6 134848 78 63354090
Paraneoplastic pemphigus 15.27 11.04 6 134848 78 63354090
Biopsy kidney 15.27 11.04 7 134847 136 63354032
Erythropoiesis abnormal 15.22 11.04 9 134845 300 63353868
Renal haemorrhage 15.21 11.04 14 134840 930 63353238
Arterial thrombosis 15.19 11.04 17 134837 1426 63352742
Pneumonia 15.16 11.04 1146 133708 455621 62898547
Ear malformation 15.12 11.04 8 134846 214 63353954
Visual impairment 15.12 11.04 111 134743 84335 63269833
Pancreatic abscess 15.11 11.04 4 134850 12 63354156
Dermatitis papillaris capillitii 15.11 11.04 4 134850 12 63354156
Eating disorder 15.09 11.04 11 134843 19005 63335163
Ear pain 15.06 11.04 34 134820 36084 63318084
Heart transplant 15.02 11.04 11 134843 529 63353639
Wound infection fungal 14.99 11.04 7 134847 142 63354026
Upper-airway cough syndrome 14.98 11.04 3 134851 11415 63342753
Dry eye 14.94 11.04 41 134813 40720 63313448
Anger 14.90 11.04 4 134850 12452 63341716
Cardio-respiratory arrest 14.88 11.04 71 134783 59888 63294280
Lip swelling 14.86 11.04 27 134827 31036 63323132
Amyloidosis 14.83 11.04 15 134839 1120 63353048
Tonsil cancer 14.82 11.04 8 134846 223 63353945
Urinary retention 14.80 11.04 26 134828 30275 63323893
Anaphylactic shock 14.80 11.04 17 134837 23616 63330552
Gastrointestinal toxicity 14.78 11.04 43 134811 7698 63346470
Hallucination 14.75 11.04 63 134791 54754 63299414
Lupus-like syndrome 14.75 11.04 7 134847 15288 63338880
Adrenal mass 14.72 11.04 14 134840 970 63353198
Enterobacter bacteraemia 14.70 11.04 10 134844 427 63353741
Atrial septal defect 14.68 11.04 40 134814 6898 63347270
Mucosal necrosis 14.67 11.04 5 134849 42 63354126
Blood creatine increased 14.67 11.04 35 134819 5566 63348602
Glomerular filtration rate decreased 14.63 11.04 62 134792 13379 63340789
Blood stem cell transplant failure 14.60 11.04 7 134847 151 63354017
Chronic myeloid leukaemia recurrent 14.57 11.04 8 134846 231 63353937
Small intestinal perforation 14.52 11.04 17 134837 1498 63352670
Gestational diabetes 14.49 11.04 45 134809 8351 63345817
Foetal growth restriction 14.47 11.04 42 134812 7511 63346657
Productive cough 14.46 11.04 77 134777 63131 63291037
Hypoacusis 14.45 11.04 18 134836 24133 63330035
Mental status changes 14.45 11.04 138 134716 39461 63314707
Oesophageal squamous cell carcinoma stage IV 14.43 11.04 4 134850 15 63354153
Throat tightness 14.42 11.04 19 134835 24868 63329300
Peritoneal dialysis 14.41 11.04 10 134844 441 63353727
Haemorrhagic ovarian cyst 14.35 11.04 12 134842 701 63353467
Coarctation of the aorta 14.33 11.04 11 134843 568 63353600
Febrile neutropenia 14.31 11.04 341 134513 118108 63236060
Enteritis infectious 14.29 11.04 20 134834 2104 63352064
Arrhythmia 14.25 11.04 38 134816 38102 63316066
Sleep apnoea syndrome 14.23 11.04 25 134829 29108 63325060
Small cell lung cancer recurrent 14.22 11.04 4 134850 16 63354152
Skin squamous cell carcinoma metastatic 14.22 11.04 4 134850 16 63354152
Acute myeloid leukaemia (in remission) 14.22 11.04 4 134850 16 63354152
Tonsillar exudate 14.22 11.04 4 134850 16 63354152
Heart rate irregular 14.18 11.04 16 134838 22405 63331763
Viral load increased 14.14 11.04 16 134838 1358 63352810
Rhinocerebral mucormycosis 14.14 11.04 10 134844 455 63353713
Spinal stenosis 14.13 11.04 7 134847 14918 63339250
Status epilepticus 14.13 11.04 67 134787 15166 63339002
Nightmare 14.10 11.04 12 134842 19182 63334986
Anaemia 14.08 11.04 760 134094 292670 63061498
Blood creatine phosphokinase increased 14.07 11.04 27 134827 30403 63323765
Intracranial pressure increased 14.05 11.04 33 134821 5194 63348974
Aortic rupture 14.03 11.04 6 134848 98 63354070
Autoimmune pancytopenia 14.03 11.04 6 134848 98 63354070
Chimerism 14.03 11.04 4 134850 17 63354151
Acute vestibular syndrome 14.03 11.04 4 134850 17 63354151
Lymphocytopenia neonatal 14.03 11.04 4 134850 17 63354151
Maternal drugs affecting foetus 13.99 11.04 33 134821 5209 63348959
Anal ulcer 13.97 11.04 11 134843 590 63353578
Vitamin D deficiency 13.95 11.04 6 134848 13886 63340282
Pyrexia 13.92 11.04 1170 133684 469308 62884860
Sporotrichosis 13.90 11.04 5 134849 50 63354118
Renal phospholipidosis 13.87 11.04 6 134848 101 63354067
Portal vein flow decreased 13.85 11.04 4 134850 18 63354150
Osteomyelitis fungal 13.85 11.04 4 134850 18 63354150
Microgenia 13.85 11.04 4 134850 18 63354150
Renal glycosuria 13.85 11.04 4 134850 18 63354150
Preterm premature rupture of membranes 13.82 11.04 16 134838 1393 63352775
Beta 2 microglobulin urine increased 13.81 11.04 5 134849 51 63354117
Neutrophilic panniculitis 13.81 11.04 5 134849 51 63354117
Dermatomyositis 13.77 11.04 23 134831 2825 63351343
Upper limb fracture 13.76 11.04 12 134842 18956 63335212
Pneumopericardium 13.73 11.04 5 134849 52 63354116
Product use issue 13.68 11.04 360 134494 220160 63134008
Panophthalmitis 13.66 11.04 6 134848 105 63354063
Death 13.62 11.04 653 134201 373728 62980440
Meningitis viral 13.61 11.04 16 134838 1415 63352753
Pelvic infection 13.58 11.04 9 134845 368 63353800
Hypogonadism 13.55 11.04 6 134848 107 63354061
Chronic cutaneous lupus erythematosus 13.51 11.04 9 134845 371 63353797
Hepatic amoebiasis 13.50 11.04 4 134850 20 63354148
Herpes simplex meningoencephalitis 13.50 11.04 4 134850 20 63354148
Vascular graft thrombosis 13.50 11.04 4 134850 20 63354148
Intentional product misuse 13.50 11.04 75 134779 60842 63293326
Infection 13.48 11.04 377 134477 228796 63125372
Renal infarct 13.47 11.04 16 134838 1431 63352737
Acquired macroglossia 13.45 11.04 7 134847 181 63353987
Anal incontinence 13.42 11.04 6 134848 13570 63340598
Acanthosis 13.41 11.04 7 134847 182 63353986
Jejunal ulcer 13.40 11.04 6 134848 110 63354058
Facial pain 13.40 11.04 3 134851 10558 63343610
Retroviral infection 13.40 11.04 3 134851 3 63354165
Infective thrombosis 13.40 11.04 3 134851 3 63354165
Antithrombin III deficiency 13.40 11.04 3 134851 3 63354165
Conjunctival neoplasm 13.40 11.04 3 134851 3 63354165
Corynebacterium bacteraemia 13.40 11.04 3 134851 3 63354165
Erdheim-Chester disease 13.40 11.04 3 134851 3 63354165
Renal cell carcinoma stage III 13.40 11.04 3 134851 3 63354165
Gastric disorder 13.39 11.04 38 134816 37331 63316837
Musculoskeletal chest pain 13.38 11.04 15 134839 21068 63333100
Dacryocystitis 13.34 11.04 4 134850 21 63354147
Rhinorrhoea 13.33 11.04 83 134771 65494 63288674
Extranodal marginal zone B-cell lymphoma (MALT type) 13.33 11.04 10 134844 499 63353669
Spinal osteoarthritis 13.32 11.04 9 134845 16177 63337991
Abnormal dreams 13.32 11.04 3 134851 10513 63343655
Myopathy 13.27 11.04 53 134801 11138 63343030
Pemphigoid 13.27 11.04 40 134814 7304 63346864
Ulcerative keratitis 13.25 11.04 22 134832 2688 63351480
Surgery 13.25 11.04 36 134818 35876 63318292
Ichthyosis 13.24 11.04 5 134849 58 63354110
Venous thrombosis 13.24 11.04 31 134823 4871 63349297
Wound dehiscence 13.23 11.04 31 134823 4872 63349296
Labelled drug-drug interaction medication error 13.21 11.04 60 134794 13339 63340829
Thyroid tuberculosis 13.19 11.04 4 134850 22 63354146
Malignant anorectal neoplasm 13.19 11.04 4 134850 22 63354146
Prescribed underdose 13.16 11.04 27 134827 29662 63324506
Hepatic echinococciasis 13.16 11.04 5 134849 59 63354109
Adenocarcinoma of colon 13.16 11.04 21 134833 2483 63351685
Anastomotic stenosis 13.13 11.04 8 134846 282 63353886
Eye swelling 13.12 11.04 19 134835 23899 63330269
Acute hepatic failure 13.12 11.04 75 134779 18252 63335916
Lymphorrhoea 13.09 11.04 5 134849 60 63354108
Micrognathia 13.08 11.04 8 134846 284 63353884
Needle issue 13.06 11.04 3 134851 10373 63343795
Cardiac valve vegetation 13.05 11.04 8 134846 285 63353883
Viral skin infection 13.04 11.04 4 134850 23 63354145
Inflammatory pseudotumour 13.04 11.04 4 134850 23 63354145
Metastatic malignant melanoma 13.01 11.04 15 134839 1300 63352868
Hypocomplementaemia 13.01 11.04 7 134847 194 63353974
Bronchoalveolar lavage abnormal 12.97 11.04 6 134848 119 63354049
Venous haemorrhage 12.95 11.04 8 134846 289 63353879
Phaeohyphomycotic brain abscess 12.94 11.04 3 134851 4 63354164
Complement fixation abnormal 12.94 11.04 3 134851 4 63354164
Herpes sepsis 12.94 11.04 3 134851 4 63354164
Portal vein stenosis 12.94 11.04 3 134851 4 63354164
Extrapyramidal disorder 12.93 11.04 6 134848 13278 63340890
Colorectal adenocarcinoma 12.93 11.04 6 134848 120 63354048
Joint tuberculosis 12.93 11.04 6 134848 120 63354048
Ecthyma 12.93 11.04 8 134846 290 63353878
Neurological symptom 12.90 11.04 34 134820 5749 63348419
Tuberculosis of genitourinary system 12.89 11.04 4 134850 24 63354144
Agnosia 12.88 11.04 6 134848 121 63354047
Mental impairment 12.86 11.04 7 134847 14144 63340024
Exposure via partner 12.84 11.04 6 134848 122 63354046
Lichen planus 12.83 11.04 20 134834 2318 63351850
Skin exfoliation 12.78 11.04 144 134710 42958 63311210
Herpes zoster meningoencephalitis 12.78 11.04 8 134846 296 63353872
Tooth abscess 12.76 11.04 8 134846 14961 63339207
Anti-interferon antibody positive 12.76 11.04 4 134850 25 63354143
Osteomyelitis bacterial 12.75 11.04 7 134847 202 63353966
Hypothyroidism 12.74 11.04 47 134807 42585 63311583
Pneumothorax spontaneous 12.73 11.04 12 134842 822 63353346
Parotitis 12.73 11.04 16 134838 1517 63352651
Mood swings 12.69 11.04 12 134842 18236 63335932
Sleep disorder due to a general medical condition 12.67 11.04 5 134849 12183 63341985
Peripheral coldness 12.63 11.04 5 134849 12160 63342008
Metapneumovirus pneumonia 12.62 11.04 4 134850 26 63354142
Mycobacterium kansasii infection 12.62 11.04 6 134848 127 63354041
Burning sensation 12.60 11.04 66 134788 54341 63299827
Eye infection 12.59 11.04 5 134849 12140 63342028
Affect lability 12.57 11.04 4 134850 11147 63343021
Erosive oesophagitis 12.56 11.04 17 134837 1733 63352435
Lower limb fracture 12.55 11.04 20 134834 24201 63329967
IIIrd nerve paralysis 12.53 11.04 11 134843 687 63353481
Blast crisis in myelogenous leukaemia 12.53 11.04 10 134844 547 63353621
Body height decreased 12.51 11.04 3 134851 10075 63344093
Hepatobiliary infection 12.49 11.04 4 134850 27 63354141
Acute generalised exanthematous pustulosis 12.48 11.04 4 134850 11095 63343073
Eye disorder 12.46 11.04 18 134836 22667 63331501
Abdominal infection 12.46 11.04 18 134836 1950 63352218
Primary biliary cholangitis 12.41 11.04 14 134840 1185 63352983
Pulmonary sepsis 12.38 11.04 16 134838 1560 63352608
Renal cell carcinoma 12.37 11.04 24 134830 3311 63350857
Dementia 12.34 11.04 13 134841 18781 63335387
Drug level changed 12.33 11.04 7 134847 216 63353952
Pulmonary arterial hypertension 12.32 11.04 18 134836 22559 63331609
Leiomyoma 12.30 11.04 9 134845 432 63353736
Drug level abnormal 12.28 11.04 6 134848 135 63354033
Oesophageal squamous cell carcinoma 12.24 11.04 6 134848 136 63354032
Papule 12.23 11.04 33 134821 5658 63348510
Emphysematous cholecystitis 12.19 11.04 3 134851 6 63354162
Meningitis aspergillus 12.19 11.04 3 134851 6 63354162
Hepatitis G 12.19 11.04 3 134851 6 63354162
Anion gap normal 12.19 11.04 3 134851 6 63354162
Hepatitis B reactivation 12.16 11.04 23 134831 3114 63351054
Bronchial anastomosis complication 12.13 11.04 4 134850 30 63354138
Nephrosclerosis 12.11 11.04 13 134841 1041 63353127
Blood pressure diastolic abnormal 12.08 11.04 8 134846 14534 63339634
Mycotic endophthalmitis 12.08 11.04 5 134849 75 63354093
Norovirus test positive 12.01 11.04 7 134847 227 63353941
Primary adrenal insufficiency 12.01 11.04 6 134848 142 63354026
Meningoencephalitis viral 12.01 11.04 8 134846 330 63353838
Ejection fraction decreased 12.00 11.04 18 134836 22314 63331854
Restless legs syndrome 11.96 11.04 13 134841 18518 63335650
Gastrointestinal pain 11.96 11.04 3 134851 9773 63344395
Renal salt-wasting syndrome 11.92 11.04 8 134846 334 63353834
Depressed level of consciousness 11.89 11.04 80 134774 61998 63292170
Pollakiuria 11.89 11.04 26 134828 27911 63326257
Middle insomnia 11.86 11.04 6 134848 12637 63341531
Fibrosis 11.86 11.04 27 134827 4165 63350003
Clostridium test positive 11.83 11.04 23 134831 3178 63350990
Walking aid user 11.81 11.04 4 134850 10713 63343455
Stenotrophomonas sepsis 11.80 11.04 4 134850 33 63354135
Refractoriness to platelet transfusion 11.80 11.04 4 134850 33 63354135
Abortion induced 11.74 11.04 48 134806 10194 63343974
Hepatic haematoma 11.74 11.04 9 134845 464 63353704
Bronchiolitis 11.73 11.04 21 134833 2726 63351442
Eye pain 11.71 11.04 35 134819 33819 63320349
B-lymphocyte count decreased 11.71 11.04 13 134841 1081 63353087
Cataract 11.71 11.04 72 134782 56981 63297187
Hepatic vein stenosis 11.69 11.04 4 134850 34 63354134
Ureteric obstruction 11.69 11.04 17 134837 1853 63352315
Renal amyloidosis 11.67 11.04 6 134848 151 63354017
Dysphagia 11.65 11.04 126 134728 88459 63265709
Campylobacter gastroenteritis 11.64 11.04 9 134845 470 63353698
Hypertensive emergency 11.61 11.04 17 134837 1865 63352303
Hepatic infection bacterial 11.59 11.04 4 134850 35 63354133
Hepatitis C virus test 11.59 11.04 3 134851 8 63354160
Herpes simplex encephalitis 11.57 11.04 8 134846 351 63353817
Dependence on respirator 11.57 11.04 5 134849 84 63354084
Immunoglobulins decreased 11.56 11.04 14 134840 1278 63352890
Rebound effect 11.55 11.04 28 134826 4498 63349670
Salmonella bacteraemia 11.53 11.04 6 134848 155 63354013
Granulomatous dermatitis 11.53 11.04 6 134848 155 63354013
Irritability 11.53 11.04 32 134822 31662 63322506
Laboratory test abnormal 11.49 11.04 25 134829 26887 63327281
Serum ferritin increased 11.48 11.04 34 134820 6148 63348020
Glomerulonephropathy 11.46 11.04 5 134849 86 63354082
Vulval cancer 11.40 11.04 11 134843 776 63353392
Pyuria 11.39 11.04 17 134837 1897 63352271
Metabolic acidosis 11.36 11.04 146 134708 44923 63309245
Injection site urticaria 11.35 11.04 8 134846 14065 63340103
Acquired mitochondrial DNA mutation 11.33 11.04 3 134851 9 63354159
Bile duct necrosis 11.33 11.04 3 134851 9 63354159
Pharyngeal necrosis 11.33 11.04 3 134851 9 63354159
Acinetobacter bacteraemia 11.30 11.04 5 134849 89 63354079
Lymphadenitis viral 11.30 11.04 4 134850 38 63354130
Dehydration 11.29 11.04 281 134573 173073 63181095
Injection site rash 11.27 11.04 14 134840 18795 63335373
Hepatic steatosis 11.26 11.04 28 134826 28741 63325427
Hepatic neoplasm 11.24 11.04 17 134837 1919 63352249
Craniotomy 11.23 11.04 7 134847 257 63353911
Jarisch-Herxheimer reaction 11.21 11.04 8 134846 369 63353799
Adenomatous polyposis coli 11.20 11.04 5 134849 91 63354077
Nodular regenerative hyperplasia 11.20 11.04 9 134845 497 63353671
Blood urea increased 11.19 11.04 95 134759 26284 63327884
Wound sepsis 11.19 11.04 6 134848 165 63354003
Escherichia test positive 11.19 11.04 19 134835 2365 63351803
Cervicitis 11.17 11.04 9 134845 499 63353669
Influenza 11.16 11.04 163 134691 108559 63245609
Amyotrophy 11.16 11.04 6 134848 166 63354002
Product substitution issue 11.15 11.04 65 134789 15931 63338237
Growth retardation 11.14 11.04 14 134840 1327 63352841
Neuralgia 11.14 11.04 24 134830 25902 63328266
Anomaly of external ear congenital 11.13 11.04 6 134848 167 63354001
Pneumonia acinetobacter 11.12 11.04 4 134850 40 63354128
Plasma cell myeloma 11.11 11.04 39 134815 35866 63318302
Normochromic normocytic anaemia 11.11 11.04 28 134826 4608 63349560
Salivary gland mass 11.10 11.04 5 134849 93 63354075
Fibrin degradation products increased 11.09 11.04 6 134848 168 63354000
Nasal septum ulceration 11.09 11.04 3 134851 10 63354158
Picornavirus infection 11.09 11.04 3 134851 10 63354158
Ventricular remodelling 11.09 11.04 3 134851 10 63354158
Biopsy heart abnormal 11.09 11.04 3 134851 10 63354158
Sputum discoloured 11.08 11.04 11 134843 16336 63337832
Phospholipidosis 11.06 11.04 6 134848 169 63353999
Metastases to lung 11.05 11.04 55 134799 12695 63341473

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Transplant rejection 3091.86 11.09 1335 169901 8976 34776719
Cytomegalovirus infection 2236.62 11.09 1464 169772 24671 34761024
Post transplant lymphoproliferative disorder 1874.10 11.09 820 170416 5708 34779987
Immunosuppressant drug level increased 1739.54 11.09 761 170475 5294 34780401
Polyomavirus-associated nephropathy 1693.29 11.09 656 170580 3188 34782507
Kidney transplant rejection 1395.47 11.09 698 170538 6799 34778896
Thrombotic microangiopathy 1298.76 11.09 748 170488 9882 34775813
Complications of transplanted kidney 1156.51 11.09 527 170709 4082 34781613
Nocardiosis 1001.53 11.09 455 170781 3496 34782199
BK virus infection 968.04 11.09 500 170736 5238 34780457
Product use in unapproved indication 952.21 11.09 1902 169334 115597 34670098
Cytomegalovirus viraemia 948.18 11.09 538 170698 6892 34778803
Acute graft versus host disease 923.01 11.09 505 170731 5998 34779697
Graft versus host disease 900.69 11.09 591 170645 9978 34775717
Transplant dysfunction 866.27 11.09 365 170871 2284 34783411
Liver transplant rejection 863.97 11.09 342 170894 1777 34783918
Drug level increased 727.24 11.09 706 170530 21390 34764305
COVID-19 706.58 11.09 1320 169916 76230 34709465
Aspergillus infection 704.77 11.09 539 170697 11715 34773980
Epstein-Barr virus infection 663.22 11.09 432 170804 7196 34778499
Mucormycosis 649.01 11.09 389 170847 5553 34780142
Chronic graft versus host disease 602.38 11.09 333 170903 4040 34781655
Fatigue 598.03 11.09 563 170673 370090 34415605
Nephropathy toxic 596.16 11.09 494 170742 12094 34773601
Adenovirus infection 594.59 11.09 352 170884 4905 34780790
Transplant failure 551.90 11.09 293 170943 3260 34782435
Drug interaction 544.53 11.09 2368 168868 223578 34562117
Graft versus host disease in skin 530 11.09 295 170941 3630 34782065
Phaeohyphomycosis 499.36 11.09 180 171056 684 34785011
Bronchopulmonary aspergillosis 498.50 11.09 477 170759 14182 34771513
Chronic allograft nephropathy 485.05 11.09 195 171041 1062 34784633
Fall 483.13 11.09 195 171041 202690 34583005
Acute graft versus host disease in skin 477.88 11.09 305 170931 4896 34780799
Dizziness 469.12 11.09 243 170993 218278 34567417
Posterior reversible encephalopathy syndrome 447.27 11.09 379 170857 9575 34776120
Pneumocystis jirovecii pneumonia 444.23 11.09 515 170721 19195 34766500
Enterococcal infection 438.12 11.09 364 170872 8942 34776753
Immunosuppressant drug level decreased 430.84 11.09 179 171057 1075 34784620
Off label use 410.37 11.09 3473 167763 416051 34369644
Delayed graft function 407.90 11.09 205 171031 2016 34783679
Kidney fibrosis 407.29 11.09 205 171031 2023 34783672
Renal impairment 401.73 11.09 1194 170042 93319 34692376
Dyspnoea 399.80 11.09 777 170459 376005 34409690
Hepatitis E 399.21 11.09 198 171038 1888 34783807
Renal transplant failure 397.35 11.09 163 171073 943 34784752
Focal segmental glomerulosclerosis 395.83 11.09 195 171041 1830 34783865
Completed suicide 394.74 11.09 21 171215 98147 34687548
Parvovirus B19 infection 380.30 11.09 147 171089 708 34784987
Acute respiratory distress syndrome 372.76 11.09 543 170693 25426 34760269
Cryptococcosis 365.89 11.09 196 171040 2223 34783472
Graft versus host disease in gastrointestinal tract 363.47 11.09 226 171010 3457 34782238
Brain abscess 363.24 11.09 213 171023 2912 34782783
Klebsiella infection 361.27 11.09 314 170922 8217 34777478
Strongyloidiasis 361.23 11.09 202 171034 2509 34783186
Polyomavirus viraemia 355.68 11.09 144 171092 801 34784894
Pain 355.60 11.09 289 170947 204386 34581309
Multiple organ dysfunction syndrome 341.26 11.09 984 170252 75582 34710113
Septic shock 323.80 11.09 927 170309 70907 34714788
Pulmonary nocardiosis 320.03 11.09 132 171104 776 34784919
Renal tubular atrophy 319.36 11.09 142 171094 1030 34784665
Pseudomonas infection 317.37 11.09 346 170890 12036 34773659
Constipation 307.75 11.09 143 171093 136839 34648856
Cytomegalovirus infection reactivation 307.18 11.09 231 171005 4887 34780808
Nausea 306.68 11.09 766 170470 339142 34446553
Asthenia 298.50 11.09 463 170773 244788 34540907
Haemophagocytic lymphohistiocytosis 294.00 11.09 340 170896 12633 34773062
Pneumatosis intestinalis 292.52 11.09 202 171034 3721 34781974
Cytomegalovirus test positive 284.84 11.09 198 171038 3688 34782007
Arthralgia 281.86 11.09 251 170985 169790 34615905
Escherichia infection 279.72 11.09 268 170968 7977 34777718
Malacoplakia 277.35 11.09 99 171137 363 34785332
Heart transplant rejection 272.21 11.09 129 171107 1102 34784593
Acute kidney injury 271.19 11.09 2475 168761 302513 34483182
Actinic keratosis 264.96 11.09 202 171034 4365 34781330
Acute graft versus host disease in intestine 259.24 11.09 163 171073 2545 34783150
Diffuse large B-cell lymphoma 258.47 11.09 244 170992 7126 34778569
Meningitis cryptococcal 253.75 11.09 154 171082 2250 34783445
Epstein-Barr virus associated lymphoproliferative disorder 252.62 11.09 143 171093 1821 34783874
Human herpesvirus 8 infection 252.49 11.09 114 171122 861 34784834
Epstein-Barr viraemia 252.45 11.09 125 171111 1187 34784508
Myocardial infarction 248.73 11.09 142 171094 120943 34664752
Infection reactivation 248.19 11.09 129 171107 1369 34784326
Rash 247.35 11.09 446 170790 222306 34563389
Varicella zoster virus infection 247.27 11.09 137 171099 1669 34784026
Hepatitis C 247.25 11.09 272 170964 9558 34776137
Malignant neoplasm progression 245.58 11.09 64 171172 87982 34697713
Renal tubular necrosis 242.81 11.09 340 170896 15340 34770355
Graft loss 240.65 11.09 107 171129 776 34784919
Pneumonia cytomegaloviral 238.94 11.09 162 171074 2892 34782803
Death 236.41 11.09 1076 170160 396973 34388722
Blastomycosis 228.76 11.09 86 171150 378 34785317
Hypotension 228.42 11.09 464 170772 221185 34564510
Cytomegalovirus colitis 228.18 11.09 152 171084 2632 34783063
Anxiety 227.59 11.09 101 171135 99327 34686368
Leukopenia 226.20 11.09 750 170486 62106 34723589
Alternaria infection 225.58 11.09 82 171154 321 34785374
Malaise 222.84 11.09 354 170882 185471 34600224
Somnolence 221.57 11.09 135 171101 110981 34674714
Pain in extremity 221.49 11.09 177 171059 126336 34659359
Blood creatinine increased 221.38 11.09 987 170249 93989 34691706
JC virus infection 216.64 11.09 135 171101 2073 34783622
Lung transplant rejection 215.93 11.09 96 171140 696 34784999
Cystitis haemorrhagic 214.57 11.09 196 171040 5483 34780212
Fungal infection 213.96 11.09 323 170913 15612 34770083
Product dose omission issue 212.69 11.09 165 171071 119546 34666149
Drug hypersensitivity 212.58 11.09 65 171171 80464 34705231
Syncope 210.71 11.09 92 171144 91359 34694336
Cryptosporidiosis infection 207.09 11.09 81 171155 405 34785290
Back pain 205.03 11.09 177 171059 121612 34664083
West Nile viral infection 198.72 11.09 89 171147 658 34785037
Scedosporium infection 193.72 11.09 92 171144 790 34784905
Depression 189.37 11.09 121 171115 96977 34688718
COVID-19 pneumonia 189.30 11.09 316 170920 16651 34769044
Dermatophytosis 188.50 11.09 63 171173 179 34785516
Hyperhidrosis 187.71 11.09 68 171168 75624 34710071
Viraemia 186.37 11.09 100 171136 1138 34784557
Respiratory failure 184.70 11.09 1032 170204 107540 34678155
Candida infection 184.53 11.09 320 170916 17395 34768300
Neurotoxicity 180.69 11.09 320 170916 17690 34768005
Human polyomavirus infection 180.09 11.09 83 171153 661 34785034
Fungal skin infection 176.36 11.09 127 171109 2507 34783188
Renal tubular injury 172.52 11.09 88 171148 895 34784800
Lymphoproliferative disorder 171.08 11.09 127 171109 2632 34783063
Peripheral swelling 168.54 11.09 82 171154 76459 34709236
Joint swelling 167.98 11.09 43 171193 59847 34725848
Toxoplasmosis 164.37 11.09 94 171142 1222 34784473
Chest pain 163.96 11.09 229 171007 126533 34659162
Feeling abnormal 163.38 11.09 53 171183 63182 34722513
Alveolar proteinosis 162.20 11.09 68 171168 419 34785276
Renal graft infection 162.10 11.09 59 171177 232 34785463
Chronic graft versus host disease in skin 161.72 11.09 84 171152 890 34784805
Squamous cell carcinoma of skin 159.68 11.09 230 171006 10651 34775044
Proteinuria 159.13 11.09 309 170927 18333 34767362
Aplasia pure red cell 158.25 11.09 172 171064 5960 34779735
Trichodysplasia spinulosa 158.22 11.09 56 171180 199 34785496
Squamous cell carcinoma 157.47 11.09 235 171001 11240 34774455
Chronic obstructive pulmonary disease 156.01 11.09 26 171210 48892 34736803
Staphylococcal infection 155.51 11.09 431 170805 32329 34753366
Human herpesvirus 6 infection 154.78 11.09 107 171129 1974 34783721
Histoplasmosis 154.48 11.09 95 171141 1423 34784272
Acute graft versus host disease in liver 154.28 11.09 96 171140 1470 34784225
Vaccination failure 151.62 11.09 85 171151 1061 34784634
Mycobacterial infection 151.08 11.09 111 171125 2263 34783432
Mycobacterium abscessus infection 148.51 11.09 66 171170 478 34785217
Post transplant distal limb syndrome 146.61 11.09 55 171181 240 34785455
Stenotrophomonas infection 146.47 11.09 104 171132 2006 34783689
Decreased appetite 146.41 11.09 379 170857 166013 34619682
Epstein-Barr virus infection reactivation 146.37 11.09 82 171154 1022 34784673
Insomnia 144.29 11.09 178 171058 103729 34681966
Intentional overdose 142.00 11.09 22 171214 43652 34742043
Haemolytic uraemic syndrome 139.00 11.09 104 171132 2182 34783513
Blood pressure increased 138.77 11.09 136 171100 87966 34697729
Pruritus 138.70 11.09 306 170930 141675 34644020
Progressive multifocal leukoencephalopathy 138.35 11.09 203 171033 9561 34776134
Complications of transplanted liver 138.09 11.09 50 171186 193 34785502
Osmotic demyelination syndrome 137.00 11.09 72 171164 783 34784912
Acinetobacter infection 136.94 11.09 81 171155 1126 34784569
Trichophytosis 136.81 11.09 53 171183 257 34785438
Venoocclusive liver disease 135.81 11.09 181 171055 7785 34777910
Urticaria 134.04 11.09 69 171167 62308 34723387
Hepatic artery thrombosis 133.39 11.09 49 171187 199 34785496
Lymphocele 133.21 11.09 83 171153 1274 34784421
Renal tubular acidosis 131.07 11.09 101 171135 2218 34783477
Muscle spasms 129.83 11.09 106 171130 74895 34710800
Drug level fluctuating 129.51 11.09 59 171177 456 34785239
Gastroenteritis norovirus 129.13 11.09 85 171151 1441 34784254
Suicide attempt 128.79 11.09 19 171217 39097 34746598
Rhodococcus infection 127.97 11.09 46 171190 173 34785522
Hypersensitivity 127.50 11.09 70 171166 60965 34724730
Epistaxis 127.32 11.09 63 171173 58188 34727507
Suicidal ideation 125.43 11.09 23 171213 40365 34745330
Rheumatoid arthritis 124.91 11.09 19 171217 38219 34747476
Disease recurrence 124.84 11.09 305 170931 21185 34764510
Disseminated cryptococcosis 124.14 11.09 80 171156 1306 34784389
Obliterative bronchiolitis 123.91 11.09 77 171159 1176 34784519
Pulmonary mucormycosis 122.80 11.09 65 171171 718 34784977
Graft versus host disease in lung 122.43 11.09 59 171177 525 34785170
Encephalitis viral 121.17 11.09 75 171161 1137 34784558
Neutrophil Pelger-Huet anomaly present 121.14 11.09 46 171190 209 34785486
Nasopharyngitis 120.97 11.09 99 171137 69869 34715826
Pneumonia cryptococcal 119.46 11.09 67 171169 837 34784858
Cardiac failure congestive 118.40 11.09 140 171096 83130 34702565
Neuropathy peripheral 118.37 11.09 140 171096 83123 34702572
Glomerulonephritis 118.08 11.09 89 171147 1889 34783806
Gait disturbance 118.03 11.09 146 171090 84994 34700701
Encephalitis 117.44 11.09 161 171075 7116 34778579
Infusion related reaction 116.54 11.09 57 171179 53000 34732695
Lymphopenia 116.05 11.09 251 170985 16084 34769611
IgA nephropathy 115.84 11.09 74 171162 1189 34784506
Malacoplakia gastrointestinal 115.81 11.09 36 171200 74 34785621
Heart rate decreased 115.43 11.09 11 171225 31734 34753961
Skin papilloma 115.40 11.09 90 171146 2013 34783682
Histoplasmosis disseminated 113.11 11.09 75 171161 1288 34784407
Drug level decreased 112.43 11.09 164 171072 7682 34778013
Tubulointerstitial nephritis 112.29 11.09 289 170947 20735 34764960
Complications of transplanted heart 111.57 11.09 46 171190 270 34785425
Endophthalmitis 111.43 11.09 110 171126 3398 34782297
Drug reaction with eosinophilia and systemic symptoms 111.11 11.09 15 171221 32997 34752698
Bradycardia 110.24 11.09 124 171112 75294 34710401
Pneumonia fungal 109.96 11.09 154 171082 6946 34778749
Renal transplant 109.94 11.09 83 171153 1766 34783929
Platelet count decreased 109.65 11.09 267 170969 119450 34666245
Musculoskeletal stiffness 108.99 11.09 46 171190 46634 34739061
Pneumocystis jirovecii infection 108.68 11.09 81 171155 1689 34784006
International normalised ratio increased 108.34 11.09 48 171188 47279 34738416
Rhabdomyolysis 107.58 11.09 105 171131 68058 34717637
Injection site pain 107.47 11.09 29 171207 38976 34746719
Paraesthesia 107.01 11.09 94 171142 64078 34721617
Inappropriate schedule of product administration 106.63 11.09 89 171147 62207 34723488
Hypoaesthesia 106.14 11.09 87 171149 61357 34724338
Atrial fibrillation 105.14 11.09 282 170954 122111 34663584
Angiosarcoma 105.06 11.09 43 171193 247 34785448
Weight increased 105.06 11.09 184 171052 92849 34692846
Pyelonephritis 104.08 11.09 140 171096 6075 34779620
Biliary anastomosis complication 103.93 11.09 33 171203 75 34785620
Organising pneumonia 103.69 11.09 137 171099 5842 34779853
Epidermodysplasia verruciformis 103.39 11.09 41 171195 214 34785481
Loss of consciousness 103.21 11.09 153 171083 82514 34703181
Pancreas transplant rejection 103.12 11.09 38 171198 156 34785539
Cerebrovascular accident 102.02 11.09 161 171075 84650 34701045
Blood creatine phosphokinase increased 101.89 11.09 46 171190 44811 34740884
Demodicidosis 101.87 11.09 39 171197 182 34785513
Pneumonia pseudomonal 101.18 11.09 110 171126 3812 34781883
Complications of transplanted lung 98.81 11.09 38 171198 180 34785515
Enterobacter infection 97.97 11.09 87 171149 2343 34783352
Graft versus host disease in liver 97.81 11.09 67 171169 1217 34784478
Vomiting 97.33 11.09 762 170474 246859 34538836
Pathogen resistance 97.06 11.09 170 171066 9312 34776383
Choroiditis 96.36 11.09 65 171171 1150 34784545
Ureteric stenosis 95.87 11.09 64 171172 1112 34784583
Papilloma viral infection 95.03 11.09 47 171189 445 34785250
Complications of transplant surgery 93.43 11.09 47 171189 463 34785232
Glomerulonephritis membranoproliferative 93.32 11.09 45 171191 401 34785294
Hydronephrosis 92.60 11.09 175 171061 10171 34775524
Human herpesvirus 6 encephalitis 92.37 11.09 42 171194 323 34785372
Systemic mycosis 92.18 11.09 70 171166 1503 34784192
Balance disorder 91.85 11.09 42 171194 40612 34745083
Wheezing 91.65 11.09 44 171192 41358 34744337
Disseminated varicella zoster virus infection 91.03 11.09 40 171196 281 34785414
Rectal haemorrhage 90.28 11.09 42 171194 40207 34745488
Smooth muscle cell neoplasm 90.15 11.09 34 171202 151 34785544
Microsporidia infection 89.71 11.09 51 171185 655 34785040
Pneumoperitoneum 88.38 11.09 72 171164 1718 34783977
Oxygen saturation decreased 88.33 11.09 80 171156 53738 34731957
Hypoglycaemia 87.57 11.09 83 171153 54557 34731138
Glomerulosclerosis 86.98 11.09 53 171183 780 34784915
Diabetes mellitus 86.63 11.09 456 170780 46417 34739278
Anogenital warts 86.45 11.09 47 171189 550 34785145
Atypical mycobacterial infection 86.10 11.09 54 171182 839 34784856
Scleroderma 85.66 11.09 67 171169 1505 34784190
Post procedural bile leak 85.06 11.09 38 171198 279 34785416
Asthma 84.70 11.09 52 171184 42604 34743091
Abdominal discomfort 84.60 11.09 101 171135 59734 34725961
Dermatitis atopic 84.33 11.09 117 171119 5230 34780465
Adenoviral haemorrhagic cystitis 84.30 11.09 41 171195 373 34785322
Agitation 84.28 11.09 94 171142 57305 34728390
Pulmonary embolism 83.86 11.09 198 171038 89548 34696147
Renal artery stenosis 83.40 11.09 77 171159 2184 34783511
Chest discomfort 82.62 11.09 87 171149 54443 34731252
Pneumonia klebsiella 82.43 11.09 91 171145 3209 34782486
Disseminated mucormycosis 82.35 11.09 44 171192 496 34785199
Cerebral aspergillosis 82.32 11.09 63 171173 1369 34784326
Pancytopenia 81.88 11.09 768 170468 94389 34691306
Nodular regenerative hyperplasia 81.85 11.09 54 171182 919 34784776
Corynebacterium infection 81.71 11.09 46 171190 579 34785116
Encapsulating peritoneal sclerosis 81.51 11.09 45 171191 544 34785151
Herpes simplex 80.82 11.09 117 171119 5442 34780253
Angioedema 80.79 11.09 41 171195 37333 34748362
Prostate cancer 80.60 11.09 47 171189 39602 34746093
Chronic hepatitis 80.17 11.09 47 171189 642 34785053
Heart rate increased 79.55 11.09 66 171170 46277 34739418
Blood pressure decreased 79.39 11.09 81 171155 51434 34734261
Contraindicated product administered 79.28 11.09 7 171229 21474 34764221
Viral haemorrhagic cystitis 79.24 11.09 57 171179 1123 34784572
General physical health deterioration 79.16 11.09 341 170895 127928 34657767
Pneumomediastinum 78.50 11.09 76 171160 2291 34783404
Contusion 78.44 11.09 40 171196 36324 34749371
Drug level above therapeutic 77.57 11.09 100 171136 4161 34781534
White blood cell count decreased 77.42 11.09 226 171010 95219 34690476
Stress 77.37 11.09 26 171210 30321 34755374
Donor specific antibody present 76.92 11.09 27 171209 93 34785602
Aggression 76.67 11.09 48 171188 38916 34746779
Unevaluable event 76.26 11.09 32 171204 32558 34753137
Therapeutic product effect incomplete 76.16 11.09 81 171155 50460 34735235
Ileal ulcer 76.01 11.09 44 171192 586 34785109
Dermoid cyst 75.90 11.09 30 171206 155 34785540
Mycoplasma infection 75.65 11.09 38 171198 373 34785322
Mycetoma mycotic 75.56 11.09 26 171210 83 34785612
Graft complication 75.30 11.09 37 171199 345 34785350
Acanthamoeba infection 74.96 11.09 38 171198 381 34785314
Atypical haemolytic uraemic syndrome 74.76 11.09 35 171201 290 34785405
Drug dependence 74.74 11.09 14 171222 24203 34761492
Neutrophil count decreased 74.69 11.09 84 171152 51020 34734675
Chronic graft versus host disease in liver 74.53 11.09 39 171197 420 34785275
Cytomegalovirus gastritis 73.77 11.09 32 171204 217 34785478
Palpitations 73.65 11.09 53 171183 39933 34745762
Angiosarcoma metastatic 73.60 11.09 22 171214 37 34785658
Nephrotic syndrome 73.54 11.09 130 171106 7173 34778522
Acute myocardial infarction 73.50 11.09 93 171143 53626 34732069
Meningitis viral 73.07 11.09 49 171187 858 34784837
Eczema herpeticum 73.03 11.09 29 171207 152 34785543
Headache 73.02 11.09 630 170606 200005 34585690
Memory impairment 72.75 11.09 63 171173 43255 34742440
Fungal endocarditis 72.50 11.09 36 171200 344 34785351
Liver transplant 72.33 11.09 75 171161 2459 34783236
Therapeutic product effect decreased 72.32 11.09 40 171196 34703 34750992
Sepsis 72.06 11.09 1181 170055 165380 34620315
Hallucination 71.67 11.09 88 171148 51410 34734285
Dry mouth 71.58 11.09 29 171207 30136 34755559
Mobility decreased 71.44 11.09 29 171207 30099 34755596
Cardiac disorder 70.89 11.09 64 171172 43062 34742633
Confusional state 70.81 11.09 415 170821 143745 34641950
Human ehrlichiosis 70.26 11.09 35 171201 337 34785358
Transplantation associated food allergy 69.95 11.09 20 171216 26 34785669
Wrong technique in product usage process 69.89 11.09 45 171191 35941 34749754
Sedation 69.61 11.09 10 171226 20996 34764699
Kaposi's sarcoma 69.46 11.09 47 171189 836 34784859
Epstein-Barr virus test positive 69.08 11.09 40 171196 533 34785162
Bacillary angiomatosis 69.03 11.09 26 171210 115 34785580
Coronary artery disease 68.86 11.09 81 171155 48224 34737471
Acute myeloid leukaemia recurrent 68.84 11.09 68 171168 2102 34783593
Toxicity to various agents 68.83 11.09 1370 169866 198992 34586703
Disease progression 68.72 11.09 284 170952 107793 34677902
Arthropathy 68.68 11.09 23 171213 26884 34758811
Intentional product misuse 67.72 11.09 74 171162 45537 34740158
Food allergy 67.53 11.09 57 171179 1431 34784264
Non-cirrhotic portal hypertension 67.46 11.09 31 171205 245 34785450
End stage renal disease 67.38 11.09 140 171096 8721 34776974
Cardio-respiratory arrest 67.33 11.09 104 171132 55169 34730526
Immune reconstitution inflammatory syndrome 67.32 11.09 139 171097 8620 34777075
Dysgeusia 67.03 11.09 23 171213 26474 34759221
Necrotising oesophagitis 66.88 11.09 39 171197 527 34785168
Osteomyelitis fungal 66.84 11.09 30 171206 223 34785472
American trypanosomiasis 66.39 11.09 30 171206 227 34785468
Hyperkalaemia 66.30 11.09 573 170663 68816 34716879
Pyelonephritis acute 66.21 11.09 65 171171 1994 34783701
Cytomegalovirus gastrointestinal infection 66.20 11.09 29 171207 202 34785493
Cerebral toxoplasmosis 66.19 11.09 60 171176 1661 34784034
Bacterial sepsis 65.66 11.09 103 171133 5147 34780548
Cardiac failure 65.64 11.09 228 171008 91020 34694675
Mycobacterium chelonae infection 65.59 11.09 44 171192 771 34784924
Central nervous system infection 65.26 11.09 41 171195 639 34785056
Myalgia 64.74 11.09 204 171032 83906 34701789
Bile duct stenosis 64.66 11.09 51 171185 1160 34784535
Meningoencephalitis herpetic 64.62 11.09 44 171192 791 34784904
Erythema 64.42 11.09 221 171015 88559 34697136
Histology abnormal 64.41 11.09 31 171205 275 34785420
Erythema infectiosum 64.01 11.09 26 171210 146 34785549
Vascular hyalinosis 63.99 11.09 22 171214 70 34785625
Toxic optic neuropathy 63.91 11.09 44 171192 806 34784889
Cytomegalovirus nephritis 63.74 11.09 24 171212 106 34785589
Dysplastic naevus 63.48 11.09 36 171200 460 34785235
Cytomegalovirus chorioretinitis 63.41 11.09 83 171153 3506 34782189
Bacterial pyelonephritis 63.13 11.09 29 171207 229 34785466
New onset diabetes after transplantation 63.12 11.09 18 171218 23 34785672
Abdominal distension 63.04 11.09 119 171117 58373 34727322
Central nervous system lymphoma 63.02 11.09 47 171189 981 34784714
Adenoviral hepatitis 63.01 11.09 37 171199 507 34785188
Cutaneous malacoplakia 62.85 11.09 22 171214 75 34785620
Dehydration 62.84 11.09 376 170860 129593 34656102
Herpes zoster meningoencephalitis 62.82 11.09 31 171205 292 34785403
Enterovirus infection 62.51 11.09 46 171190 940 34784755
Hypertrophic cardiomyopathy 62.37 11.09 49 171187 1108 34784587
Flushing 62.33 11.09 41 171195 32379 34753316
Cystitis viral 62.32 11.09 37 171199 518 34785177
Fusarium infection 62.26 11.09 49 171187 1111 34784584
Pericarditis fungal 62.05 11.09 25 171211 137 34785558
Drug ineffective for unapproved indication 61.71 11.09 255 170981 23460 34762235
Gastroenteritis sapovirus 61.68 11.09 24 171212 118 34785577
Febrile neutropenia 61.47 11.09 405 170831 136444 34649251
Oedema peripheral 61.47 11.09 340 170896 119472 34666223
Gingival hypertrophy 61.39 11.09 59 171177 1762 34783933
Heartland virus infection 60.84 11.09 17 171219 19 34785676
Reversible cerebral vasoconstriction syndrome 60.74 11.09 34 171202 423 34785272
Cytomegalovirus enteritis 60.09 11.09 35 171201 472 34785223
Drug resistance 59.95 11.09 269 170967 25658 34760037
Hepatic cancer recurrent 59.86 11.09 30 171206 293 34785402
Gastroenteritis cryptosporidial 59.85 11.09 26 171210 177 34785518
Oliguria 59.78 11.09 129 171107 8251 34777444
Full blood count abnormal 59.33 11.09 10 171226 18658 34767037
Steroid diabetes 59.15 11.09 63 171173 2132 34783563
Haemodialysis 58.59 11.09 147 171089 10379 34775316
Bacteraemia 58.56 11.09 221 171015 19496 34766199
Periostitis 58.24 11.09 29 171207 279 34785416
Hypokalaemia 57.97 11.09 124 171112 58090 34727605
Polyomavirus test positive 57.93 11.09 22 171214 100 34785595
Nephropathy 57.88 11.09 104 171132 5813 34779882
Intestine transplant rejection 57.86 11.09 17 171219 26 34785669
Purtscher retinopathy 57.85 11.09 15 171221 9 34785686
Cytomegalovirus oesophagitis 57.52 11.09 34 171202 472 34785223
Encephalopathy 57.48 11.09 332 170904 34987 34750708
Loss of personal independence in daily activities 57.25 11.09 47 171189 33132 34752563
Photodermatosis 56.69 11.09 35 171201 528 34785167
Weight decreased 56.62 11.09 571 170665 175730 34609965
Emphysematous pyelonephritis 56.36 11.09 18 171218 42 34785653
Hepatic artery stenosis 56.36 11.09 23 171213 131 34785564
Urinary tract infection bacterial 56.22 11.09 58 171178 1890 34783805
Flatulence 56.10 11.09 17 171219 21181 34764514
Arthritis 55.85 11.09 43 171193 31303 34754392
Disseminated tuberculosis 55.41 11.09 61 171175 2144 34783551
Escherichia urinary tract infection 55.04 11.09 77 171159 3469 34782226
Clostridium difficile colitis 55.00 11.09 186 171050 15544 34770151
Hot flush 54.58 11.09 11 171225 18055 34767640
Burkholderia cepacia complex infection 54.57 11.09 24 171212 169 34785526
Wound dehiscence 54.55 11.09 74 171162 3237 34782458
Opportunistic infection 54.54 11.09 53 171183 1605 34784090
Respiratory arrest 54.54 11.09 35 171201 28008 34757687
Neck pain 54.49 11.09 28 171208 25321 34760374
Transient ischaemic attack 54.34 11.09 34 171202 27579 34758116
Fungaemia 54.34 11.09 65 171171 2503 34783192
Enterococcal sepsis 54.17 11.09 53 171183 1619 34784076
Mycobacterium avium complex infection 53.86 11.09 64 171172 2447 34783248
Engraftment syndrome 53.26 11.09 42 171194 955 34784740
Transplantation complication 53.24 11.09 22 171214 130 34785565
Urinoma 53.21 11.09 25 171211 209 34785486
Ureaplasma infection 53.15 11.09 29 171207 342 34785353
Hepatocellular carcinoma 52.89 11.09 115 171121 7394 34778301
Ascites 52.84 11.09 400 170836 46171 34739524
Emphysematous cystitis 52.82 11.09 20 171216 90 34785605
Philadelphia positive chronic myeloid leukaemia 52.59 11.09 21 171215 112 34785583
Labelled drug-drug interaction medication error 52.55 11.09 177 171059 14762 34770933
Muscular weakness 52.51 11.09 182 171054 72715 34712980
Solar lentigo 52.43 11.09 33 171203 516 34785179
C3 glomerulopathy 52.42 11.09 18 171218 57 34785638
Primary effusion lymphoma 52.25 11.09 15 171221 20 34785675
Upper gastrointestinal haemorrhage 52.21 11.09 30 171206 25488 34760207
Hepatic fibrosis 51.63 11.09 86 171150 4521 34781174
Adverse drug reaction 51.33 11.09 41 171195 29301 34756394
Humoral immune defect 51.24 11.09 23 171213 171 34785524
Cytomegalovirus enterocolitis 51.23 11.09 41 171195 953 34784742
Liver transplant failure 51.18 11.09 19 171217 80 34785615
Prostatic specific antigen increased 51.02 11.09 6 171230 14674 34771021
Large intestinal ulcer 50.40 11.09 55 171181 1914 34783781
Enterococcal bacteraemia 50.33 11.09 54 171182 1843 34783852
Dyspnoea exertional 50.28 11.09 84 171152 43195 34742500
Norovirus infection 50.13 11.09 22 171214 154 34785541
Mediastinitis 49.92 11.09 35 171201 661 34785034
Meningoencephalitis viral 49.88 11.09 21 171215 131 34785564
Graft infection 49.80 11.09 30 171206 432 34785263
Biliary tract disorder 49.67 11.09 41 171195 997 34784698
Chronic kidney disease 49.62 11.09 359 170877 40851 34744844
Prophylaxis against transplant rejection 49.62 11.09 16 171220 39 34785656
Cough 49.56 11.09 483 170753 149657 34636038
Injection site erythema 49.47 11.09 9 171227 15890 34769805
Lung transplant 49.15 11.09 55 171181 1969 34783726
Overdose 49.13 11.09 254 170982 90805 34694890
Heart rate irregular 49.08 11.09 9 171227 15798 34769897
Hyponatraemia 49.06 11.09 223 171013 82468 34703227
Low birth weight baby 48.92 11.09 115 171121 7790 34777905
Full blood count decreased 48.79 11.09 14 171222 18074 34767621
Muscle abscess 48.77 11.09 33 171203 587 34785108
Chills 48.41 11.09 218 171018 80825 34704870
Hypogammaglobulinaemia 48.33 11.09 113 171123 7627 34778068
B-cell lymphoma 48.30 11.09 81 171155 4282 34781413
Liver abscess 48.13 11.09 76 171160 3819 34781876
Disseminated blastomycosis 48.09 11.09 21 171215 145 34785550
Urinary fistula 47.78 11.09 19 171217 100 34785595
Pneumonia bacterial 47.49 11.09 147 171089 11725 34773970
Choriomeningitis lymphocytic 47.42 11.09 14 171222 22 34785673
Blood glucose increased 47.10 11.09 168 171068 66550 34719145
Atypical mycobacterial pneumonia 47.07 11.09 20 171216 128 34785567
Intentional self-injury 46.95 11.09 6 171230 13765 34771930
Diaphragmatic hernia 46.89 11.09 24 171212 246 34785449
Idiopathic pneumonia syndrome 46.89 11.09 24 171212 246 34785449
Respiratory depression 46.82 11.09 11 171225 16234 34769461
Abdominal pain upper 46.58 11.09 186 171050 71304 34714391
Autoimmune haemolytic anaemia 46.52 11.09 81 171155 4415 34781280
Disseminated intravascular coagulation 46.48 11.09 221 171015 21595 34764100
Morganella infection 46.43 11.09 30 171206 492 34785203
Tachycardia 45.99 11.09 236 171000 84536 34701159
Tremor 45.60 11.09 611 170625 81976 34703719
Drug withdrawal syndrome 45.56 11.09 20 171216 19814 34765881
Bronchitis 45.54 11.09 85 171151 41878 34743817
Drug level changed 45.46 11.09 26 171210 338 34785357
Coronavirus infection 45.10 11.09 78 171158 4229 34781466
Chronic graft versus host disease oral 45.06 11.09 19 171217 119 34785576
Cholangitis 44.90 11.09 118 171118 8571 34777124
Cutaneous nocardiosis 44.75 11.09 20 171216 147 34785548
Laboratory test abnormal 44.62 11.09 22 171214 20369 34765326
Osteonecrosis of jaw 44.44 11.09 16 171220 17873 34767822
Microangiopathy 44.23 11.09 37 171199 917 34784778
Osteoarthritis 44.08 11.09 23 171213 20619 34765076
Bacterial infection 44.02 11.09 183 171053 16880 34768815
Basal cell carcinoma 43.98 11.09 202 171034 19456 34766239
Oropharyngeal pain 43.94 11.09 66 171170 35419 34750276
Anuria 43.80 11.09 131 171105 10254 34775441
Bronchiolitis obliterans syndrome 43.76 11.09 21 171215 185 34785510
Bone marrow transplant rejection 43.66 11.09 21 171215 186 34785509
Postoperative wound infection 43.64 11.09 82 171154 4744 34780951
Optic atrophy 43.52 11.09 36 171200 878 34784817
Orf 43.44 11.09 13 171223 22 34785673
Blood pressure fluctuation 43.27 11.09 36 171200 25213 34760482
Neutralising antibodies negative 43.24 11.09 10 171226 0 34785695
Nasal congestion 43.19 11.09 30 171206 23027 34762668
Orthostatic hypotension 43.15 11.09 38 171198 25881 34759814
Musculoskeletal pain 43.02 11.09 56 171180 31907 34753788
Nightmare 42.98 11.09 9 171227 14382 34771313
Staphylococcal bacteraemia 42.89 11.09 114 171122 8338 34777357
Herpes simplex hepatitis 42.52 11.09 17 171219 91 34785604
Graft versus host disease in eye 42.44 11.09 22 171214 232 34785463
Plasma cell myeloma 42.30 11.09 89 171147 41948 34743747
Haematemesis 42.20 11.09 44 171192 27667 34758028
Tinnitus 42.10 11.09 23 171213 20095 34765600
Tularaemia 42.07 11.09 17 171219 94 34785601
Malignant fibrous histiocytoma 42.00 11.09 21 171215 204 34785491
Chronic graft versus host disease in eye 41.92 11.09 17 171219 95 34785600
Renal failure 41.88 11.09 884 170352 129673 34656022
Adverse event 41.86 11.09 20 171216 18857 34766838
Dysphonia 41.76 11.09 32 171204 23351 34762344
Superinfection bacterial 41.65 11.09 35 171201 873 34784822
Skin squamous cell carcinoma recurrent 41.58 11.09 14 171222 41 34785654
Portal vein thrombosis 41.50 11.09 70 171166 3718 34781977
Thyroid gland abscess 41.41 11.09 15 171221 58 34785637
Erectile dysfunction 41.18 11.09 25 171211 20612 34765083
Dyspepsia 41.11 11.09 73 171163 36659 34749036
Abdominal wall abscess 41.04 11.09 28 171208 505 34785190
Gastrooesophageal reflux disease 40.99 11.09 77 171159 37847 34747848
Transitional cell carcinoma 40.83 11.09 52 171184 2137 34783558
Glomerulonephritis membranous 40.77 11.09 39 171197 1158 34784537
Oesophageal achalasia 40.73 11.09 25 171211 373 34785322
Isosporiasis 40.52 11.09 17 171219 105 34785590
Capillaritis 40.38 11.09 17 171219 106 34785589
Perinephric collection 39.92 11.09 19 171217 164 34785531
Cat scratch disease 39.82 11.09 19 171217 165 34785530
Venoocclusive disease 39.74 11.09 59 171177 2808 34782887
Infectious thyroiditis 39.66 11.09 16 171220 88 34785607
Lung consolidation 39.65 11.09 89 171147 5847 34779848
Cerebral fungal infection 39.56 11.09 22 171214 270 34785425
Skin squamous cell carcinoma metastatic 39.50 11.09 14 171222 50 34785645
Skin necrosis 39.37 11.09 88 171148 5765 34779930
Penicillium infection 39.22 11.09 17 171219 115 34785580
Peritonitis pneumococcal 39.15 11.09 12 171224 23 34785672
Blood pressure systolic increased 39.00 11.09 33 171203 22919 34762776
Cytomegalovirus gastroenteritis 38.91 11.09 20 171216 207 34785488
Urinary tract infection viral 38.82 11.09 12 171224 24 34785671
Toxic skin eruption 38.72 11.09 5 171231 11380 34774315
Cholangitis sclerosing 38.67 11.09 41 171195 1380 34784315
Intestinal tuberculosis 38.62 11.09 17 171219 120 34785575
Vision blurred 38.59 11.09 107 171129 45856 34739839
Blood potassium decreased 38.19 11.09 20 171216 17895 34767800
Tick-borne viral encephalitis 38.17 11.09 11 171225 15 34785680
Ventricular remodelling 38.03 11.09 15 171221 77 34785618
Locked-in syndrome 38.03 11.09 21 171215 254 34785441
Renal vein thrombosis 37.95 11.09 18 171218 154 34785541
Road traffic accident 37.92 11.09 19 171217 17431 34768264
BK polyomavirus test positive 37.87 11.09 12 171224 27 34785668
Neoplasm progression 37.78 11.09 35 171201 23265 34762430
Electrocardiogram QT prolonged 37.71 11.09 91 171145 40861 34744834
Gastroenteritis adenovirus 37.69 11.09 17 171219 128 34785567
Abnormal behaviour 37.62 11.09 40 171196 24929 34760766
Lethargy 37.37 11.09 92 171144 41030 34744665
Cholestasis 37.33 11.09 243 170993 26705 34758990
Cytomegalovirus hepatitis 37.27 11.09 25 171211 438 34785257
Serotonin syndrome 37.25 11.09 26 171210 19907 34765788
Trichosporon infection 37.24 11.09 30 171206 704 34784991
Renal tubular disorder 37.24 11.09 75 171161 4568 34781127
Pulmonary tuberculosis 37.19 11.09 76 171160 4678 34781017
Paranoia 37.19 11.09 7 171229 12061 34773634
Herpes zoster cutaneous disseminated 37.18 11.09 18 171218 162 34785533
Hepatic failure 37.17 11.09 293 170943 34238 34751457
Histoplasmosis cutaneous 37.00 11.09 12 171224 30 34785665
Ureteral necrosis 36.99 11.09 13 171223 45 34785650
Biloma 36.98 11.09 14 171222 63 34785632
Palmar-plantar erythrodysaesthesia syndrome 36.93 11.09 18 171218 16777 34768918
Cognitive disorder 36.87 11.09 52 171184 28641 34757054
Epstein Barr virus positive mucocutaneous ulcer 36.86 11.09 23 171213 354 34785341
Granuloma 36.85 11.09 61 171175 3190 34782505
Post procedural urine leak 36.82 11.09 17 171219 136 34785559
Chronic hepatitis C 36.76 11.09 24 171212 401 34785294
Anaphylactic shock 36.73 11.09 16 171220 15925 34769770
Irritability 36.71 11.09 40 171196 24650 34761045
Aspergilloma 36.63 11.09 22 171214 315 34785380
Rhinorrhoea 36.62 11.09 43 171193 25625 34760070
Stevens-Johnson syndrome 36.61 11.09 23 171213 18616 34767079
Device issue 36.59 11.09 3 171233 9774 34775921
Anastomotic stenosis 36.45 11.09 21 171215 277 34785418
Disturbance in attention 36.44 11.09 44 171192 25901 34759794
Haematochezia 36.40 11.09 112 171124 46422 34739273
Abscess fungal 36.35 11.09 20 171216 240 34785455
Gait inability 36.32 11.09 29 171207 20729 34764966
Scrotal ulcer 36.31 11.09 25 171211 458 34785237
Graft thrombosis 36.06 11.09 21 171215 283 34785412
Cutaneous T-cell lymphoma 36.00 11.09 41 171195 1497 34784198
Pneumopericardium 35.99 11.09 16 171220 116 34785579
Dyskinesia 35.95 11.09 34 171202 22379 34763316
Synovitis 35.94 11.09 12 171224 14054 34771641
Inferior vena cava stenosis 35.92 11.09 11 171225 21 34785674
Central nervous system lesion 35.70 11.09 90 171146 6373 34779322
Oxalosis 35.58 11.09 11 171225 22 34785673
Dehiscence 35.57 11.09 15 171221 94 34785601
Rib fracture 35.56 11.09 13 171223 14387 34771308
Portal hypertension 35.47 11.09 68 171168 3994 34781701
Hepatosplenomegaly 35.44 11.09 69 171167 4100 34781595
Passenger lymphocyte syndrome 35.43 11.09 12 171224 36 34785659
Postoperative thoracic procedure complication 35.43 11.09 12 171224 36 34785659
Lymphadenitis bacterial 35.43 11.09 12 171224 36 34785659
Muir-Torre syndrome 35.41 11.09 10 171226 12 34785683
Sopor 35.41 11.09 8 171228 12128 34773567
Epstein-Barr virus associated lymphoma 35.38 11.09 28 171208 640 34785055
Body temperature decreased 35.32 11.09 10 171226 13024 34772671
Injection site reaction 35.31 11.09 10 171226 13023 34772672
Oesophageal perforation 35.15 11.09 36 171200 1163 34784532
Arrhythmia 35.04 11.09 77 171159 35731 34749964
Skin laceration 35.02 11.09 9 171227 12500 34773195
Cold sweat 34.91 11.09 4 171232 9983 34775712
Injury 34.83 11.09 30 171206 20657 34765038
Bone pain 34.83 11.09 30 171206 20656 34765039
Meningitis fungal 34.79 11.09 15 171221 100 34785595
Tuberculosis gastrointestinal 34.75 11.09 19 171217 225 34785470
Aortic pseudoaneurysm 34.71 11.09 12 171224 39 34785656
Urinary tract infection enterococcal 34.69 11.09 31 171205 842 34784853
Enteritis 34.62 11.09 103 171133 8039 34777656
Biopsy kidney abnormal 34.42 11.09 15 171221 103 34785592
Soft tissue mass 34.32 11.09 33 171203 986 34784709
Klebsiella sepsis 34.28 11.09 46 171190 1991 34783704
Intracranial pressure increased 34.28 11.09 66 171170 3889 34781806
Amnesia 34.27 11.09 48 171188 26515 34759180
Product prescribing error 34.24 11.09 37 171199 22890 34762805
Klebsiella bacteraemia 34.19 11.09 38 171198 1350 34784345
Cytokine release syndrome 34.08 11.09 37 171199 22840 34762855
Optic neuropathy 34.03 11.09 45 171191 1920 34783775
H1N1 influenza 34.01 11.09 32 171204 930 34784765
Hepatitis C RNA increased 34.00 11.09 20 171216 275 34785420
Sinusitis aspergillus 33.98 11.09 14 171222 82 34785613
Gastric haemorrhage 33.73 11.09 5 171231 10256 34775439
Disseminated aspergillosis 33.60 11.09 29 171207 751 34784944
Pain in jaw 33.54 11.09 11 171225 13029 34772666
Head injury 33.53 11.09 24 171212 18136 34767559
Pleocytosis 33.31 11.09 25 171211 527 34785168
Systemic candida 33.31 11.09 63 171173 3663 34782032
Pharyngeal polyp 33.23 11.09 9 171227 8 34785687
Ejection fraction decreased 33.21 11.09 27 171209 19127 34766568
Swollen tongue 33.12 11.09 15 171221 14590 34771105
Arteritis infective 33.03 11.09 10 171226 18 34785677
Protothecosis 32.98 11.09 11 171225 31 34785664
Withdrawal syndrome 32.93 11.09 10 171226 12445 34773250
Gastrointestinal mucormycosis 32.90 11.09 17 171219 178 34785517
Pulmonary alveolar haemorrhage 32.86 11.09 96 171140 7416 34778279
Anaphylactic reaction 32.82 11.09 68 171168 32233 34753462
Angina pectoris 32.74 11.09 65 171171 31298 34754397
Diabetic cardiomyopathy 32.68 11.09 10 171226 19 34785676
Multimorbidity 32.67 11.09 31 171205 911 34784784
Renal lymphocele 32.61 11.09 12 171224 49 34785646
Chronic myeloid leukaemia 32.61 11.09 47 171189 2177 34783518
Hepatitis B reactivation 32.59 11.09 64 171172 3827 34781868
Incorrect route of product administration 32.50 11.09 16 171220 14829 34770866
Rash pruritic 32.50 11.09 51 171185 26890 34758805
Eye abscess 32.30 11.09 16 171220 152 34785543
Toxic epidermal necrolysis 32.25 11.09 35 171201 21611 34764084
Coma 32.24 11.09 115 171121 45563 34740132
Serratia infection 32.17 11.09 30 171206 862 34784833
Chimerism 32.08 11.09 18 171218 225 34785470
Subcapsular renal haematoma 32.00 11.09 22 171214 402 34785293
Burning sensation 31.80 11.09 26 171210 18368 34767327
Nephritis haemorrhagic 31.78 11.09 9 171227 11 34785684
Presyncope 31.65 11.09 28 171208 19031 34766664
Disseminated mycobacterium avium complex infection 31.57 11.09 13 171223 76 34785619
Injection site haemorrhage 31.56 11.09 5 171231 9763 34775932
Glomerulonephritis rapidly progressive 31.51 11.09 26 171210 632 34785063
Underdose 31.49 11.09 14 171222 13766 34771929
Dysarthria 31.46 11.09 78 171158 34704 34750991
Lip swelling 31.36 11.09 20 171216 16060 34769635
Hyperplasia 31.31 11.09 25 171211 579 34785116
Medication error 31.22 11.09 48 171188 25517 34760178
Gastrointestinal fungal infection 31.17 11.09 16 171220 165 34785530
Skin discolouration 31.13 11.09 25 171211 17820 34767875
Visceral leishmaniasis 31.02 11.09 25 171211 587 34785108
Fungal abscess central nervous system 30.97 11.09 14 171222 106 34785589
Dengue fever 30.95 11.09 18 171218 242 34785453
Gastroenteritis Escherichia coli 30.91 11.09 21 171215 376 34785319
Portal vein occlusion 30.84 11.09 12 171224 59 34785636
Chronic graft versus host disease in intestine 30.76 11.09 18 171218 245 34785450
Gastrointestinal haemorrhage 30.71 11.09 281 170955 88196 34697499
Aspartate aminotransferase increased 30.70 11.09 200 171036 67583 34718112
Miosis 30.54 11.09 5 171231 9530 34776165
Sporotrichosis 30.52 11.09 12 171224 61 34785634
Perinephric abscess 30.47 11.09 11 171225 42 34785653
Herpes virus infection 30.45 11.09 52 171184 2790 34782905
Serum sickness 30.40 11.09 43 171193 1957 34783738
Granulomatous dermatitis 30.38 11.09 18 171218 251 34785444
Seroma 30.35 11.09 25 171211 606 34785089
Acanthoma 30.29 11.09 10 171226 27 34785668
Acanthamoeba keratitis 30.27 11.09 7 171229 0 34785695
Oral hairy leukoplakia 30.27 11.09 7 171229 0 34785695
Coccidioidomycosis 30.01 11.09 27 171209 740 34784955
Plasmablastic lymphoma 29.98 11.09 20 171216 347 34785348
Drug eruption 29.84 11.09 32 171204 19866 34765829
Necrotising retinitis 29.75 11.09 28 171208 814 34784881
Faeces discoloured 29.72 11.09 18 171218 14860 34770835
Poor quality sleep 29.64 11.09 3 171233 8253 34777442
Hepatic vein stenosis 29.60 11.09 8 171228 7 34785688
Intraductal papillary mucinous neoplasm 29.58 11.09 23 171213 512 34785183
Haemoglobin decreased 29.55 11.09 415 170821 120357 34665338
Psoriatic arthropathy 29.51 11.09 32 171204 19766 34765929
Hypoacusis 29.50 11.09 22 171214 16279 34769416
Steatohepatitis 29.33 11.09 19 171217 313 34785382
Hypersomnia 29.32 11.09 12 171224 12395 34773300
Neuroendocrine carcinoma of the skin 29.29 11.09 27 171209 764 34784931
Endocarditis 29.25 11.09 84 171152 6427 34779268
C-reactive protein abnormal 29.20 11.09 4 171232 8706 34776989
Infective aneurysm 29.17 11.09 24 171212 581 34785114
Injection site swelling 29.16 11.09 10 171226 11517 34774178
Feeling cold 29.13 11.09 8 171228 10631 34775064
Influenza like illness 29.08 11.09 57 171179 27577 34758118
Infection in an immunocompromised host 29.08 11.09 25 171211 644 34785051
Rectal prolapse 29.06 11.09 22 171214 470 34785225
Neuroleptic malignant syndrome 29.01 11.09 27 171209 17907 34767788
Disseminated coccidioidomycosis 28.89 11.09 12 171224 72 34785623
Emotional distress 28.88 11.09 19 171217 15007 34770688
Glomerulonephritis proliferative 28.87 11.09 16 171220 195 34785500
Kidney rupture 28.80 11.09 16 171220 196 34785499
Guillain-Barre syndrome 28.78 11.09 80 171156 6007 34779688
Drug level below therapeutic 28.76 11.09 76 171160 5539 34780156
Appendicolith 28.72 11.09 4 171232 8597 34777098
Herpes zoster oticus 28.66 11.09 16 171220 198 34785497
Proteus infection 28.49 11.09 31 171205 1075 34784620
Parvovirus infection 28.42 11.09 21 171215 432 34785263
Central nervous system vasculitis 28.40 11.09 22 171214 487 34785208
Diffuse mesangial sclerosis 28.28 11.09 11 171225 54 34785641
Dysphagia 28.28 11.09 184 171052 62197 34723498
Haemosiderosis 28.24 11.09 18 171218 288 34785407
Neurological symptom 28.24 11.09 63 171173 4122 34781573
Pallor 28.19 11.09 51 171185 25429 34760266
Cutaneous blastomycosis 28.18 11.09 9 171227 21 34785674
Mycobacterium fortuitum infection 28.16 11.09 15 171221 168 34785527
Inflammatory bowel disease 28.15 11.09 51 171185 2869 34782826
Candida sepsis 28.10 11.09 33 171203 1246 34784449
Renal cyst haemorrhage 28.02 11.09 24 171212 615 34785080
Sinusitis fungal 28.01 11.09 23 171213 555 34785140
Skin lesion 27.99 11.09 194 171042 21767 34763928
Depressed mood 27.94 11.09 32 171204 19285 34766410
Disseminated cytomegaloviral infection 27.84 11.09 16 171220 210 34785485
Burkholderia cepacia complex sepsis 27.78 11.09 7 171229 3 34785692
Adult T-cell lymphoma/leukaemia 27.73 11.09 14 171222 139 34785556
Ecthyma 27.65 11.09 21 171215 451 34785244
Lymphocytic infiltration 27.64 11.09 25 171211 690 34785005
Swelling face 27.62 11.09 44 171192 23061 34762634
Oesophageal ulcer 27.58 11.09 55 171181 3326 34782369
Meningitis bacterial 27.52 11.09 33 171203 1274 34784421
Transitional cell carcinoma metastatic 27.34 11.09 10 171226 40 34785655
Deep vein thrombosis 27.33 11.09 197 171039 65051 34720644
Restlessness 27.31 11.09 52 171184 25430 34760265
Hyperparathyroidism secondary 27.30 11.09 36 171200 1532 34784163
Urinary retention 27.21 11.09 89 171147 36199 34749496
Incision site pain 27.18 11.09 39 171197 1799 34783896
Electrocardiogram abnormal 27.17 11.09 6 171230 9241 34776454
Chemical peritonitis 27.14 11.09 13 171223 114 34785581
Cryptococcal cutaneous infection 27.11 11.09 12 171224 86 34785609
Engraft failure 27.06 11.09 21 171215 466 34785229
Thrombosis 27.06 11.09 141 171095 50317 34735378
Diffuse alveolar damage 27.02 11.09 44 171192 2270 34783425
Dementia 26.95 11.09 17 171219 13731 34771964
Sleep apnoea syndrome 26.94 11.09 36 171200 20285 34765410
Joint injury 26.86 11.09 6 171230 9167 34776528
Portal fibrosis 26.85 11.09 18 171218 315 34785380
Sinusitis 26.78 11.09 108 171128 41294 34744401
Nephrolithiasis 26.68 11.09 69 171167 30264 34755431
Encephalitis cytomegalovirus 26.67 11.09 23 171213 595 34785100
Pneumonia aspiration 26.67 11.09 110 171126 41793 34743902
Anaplastic large cell lymphoma T- and null-cell types 26.65 11.09 12 171224 90 34785605
Hepatic necrosis 26.60 11.09 58 171178 3736 34781959
Legionella infection 26.46 11.09 21 171215 482 34785213
Cell death 26.42 11.09 44 171192 2313 34783382
Corneal endotheliitis 26.41 11.09 10 171226 45 34785650
Chromoblastomycosis 26.41 11.09 10 171226 45 34785650
Angina unstable 26.37 11.09 12 171224 11641 34774054
Viral test positive 26.36 11.09 15 171221 193 34785502
Diarrhoea haemorrhagic 26.36 11.09 83 171153 6681 34779014
Mouth ulceration 26.35 11.09 122 171114 11788 34773907
Escherichia bacteraemia 26.33 11.09 53 171183 3227 34782468
Meningoencephalitis amoebic 26.29 11.09 13 171223 123 34785572
Subdural haematoma 26.24 11.09 37 171199 20384 34765311
Spinal fracture 26.22 11.09 3 171233 7495 34778200
Cyanosis 26.12 11.09 15 171221 12749 34772946
Human herpesvirus 6 infection reactivation 26.11 11.09 14 171222 159 34785536
Arterial rupture 26.10 11.09 21 171215 492 34785203
Meningomyelitis herpes 26.09 11.09 9 171227 29 34785666
Central nervous system fungal infection 26.04 11.09 18 171218 332 34785363
Pathergy reaction 25.96 11.09 7 171229 6 34785689
Immunosuppressant drug level 25.94 11.09 6 171230 0 34785695
Increased appetite 25.91 11.09 3 171233 7426 34778269
Obstructive nephropathy 25.86 11.09 9 171227 30 34785665
Pyelonephritis fungal 25.81 11.09 11 171225 71 34785624
Hypothyroidism 25.76 11.09 39 171197 20863 34764832
Anger 25.73 11.09 13 171223 11871 34773824
Zoonotic bacterial infection 25.73 11.09 10 171226 49 34785646
Nocturia 25.58 11.09 9 171227 10201 34775494
Chronic myelomonocytic leukaemia 25.54 11.09 23 171213 631 34785064
Pulmonary air leakage 25.52 11.09 14 171222 167 34785528
Fungal sepsis 25.43 11.09 26 171210 838 34784857
Sebaceous carcinoma 25.43 11.09 11 171225 74 34785621
Systemic bacterial infection 25.42 11.09 9 171227 32 34785663
Varicella 25.41 11.09 36 171200 1641 34784054
Troponin increased 25.35 11.09 12 171224 11377 34774318
Thrombotic thrombocytopenic purpura 25.33 11.09 53 171183 3317 34782378
Glomerulonephropathy 25.33 11.09 15 171221 209 34785486
Pulmonary mass 25.29 11.09 127 171109 12685 34773010
Haemodynamic instability 25.24 11.09 103 171133 9420 34776275
Evans syndrome 25.21 11.09 16 171220 254 34785441
Viral vasculitis 25.19 11.09 11 171225 76 34785619
Hepatic vein occlusion 25.16 11.09 14 171222 172 34785523
IVth nerve paralysis 25.07 11.09 12 171224 105 34785590
Vascular pseudoaneurysm 25.02 11.09 41 171195 2126 34783569
Limb injury 24.99 11.09 13 171223 11676 34774019
Bile duct necrosis 24.97 11.09 7 171229 8 34785687
Sleep disorder 24.97 11.09 76 171160 31612 34754083
Kaposi sarcoma inflammatory cytokine syndrome 24.95 11.09 8 171228 19 34785676
Pneumonia influenzal 24.95 11.09 34 171202 1494 34784201
Red blood cell sedimentation rate increased 24.88 11.09 7 171229 9155 34776540
Metastases to lung 24.86 11.09 101 171135 9219 34776476
Hyperammonaemia 24.69 11.09 78 171158 6289 34779406
Salivary hypersecretion 24.62 11.09 6 171230 8638 34777057
Mucosal hypertrophy 24.61 11.09 9 171227 36 34785659
Eosinophilic colitis 24.54 11.09 15 171221 222 34785473
Yersinia infection 24.52 11.09 7 171229 9 34785686
Schistocytosis 24.52 11.09 7 171229 9 34785686
Metastatic squamous cell carcinoma 24.52 11.09 20 171216 478 34785217
Ventricular tachycardia 24.51 11.09 59 171177 26520 34759175
Brain herniation 24.46 11.09 58 171178 3950 34781745
Hallucination, auditory 24.39 11.09 14 171222 11903 34773792
Akathisia 24.36 11.09 5 171231 8104 34777591
Hyperglycaemia 24.27 11.09 298 170938 39182 34746513
Anhedonia 24.24 11.09 4 171232 7581 34778114
Premature baby 24.18 11.09 172 171064 19461 34766234
Hepatitis C virus test 24.07 11.09 10 171226 60 34785635
Pancreatitis haemorrhagic 24.07 11.09 17 171219 325 34785370
Stem cell transplant 24.07 11.09 40 171196 2099 34783596
Limb discomfort 24.05 11.09 12 171224 11035 34774660
Staphylococcal scalded skin syndrome 24.02 11.09 16 171220 277 34785418
Dysstasia 24.01 11.09 15 171221 12180 34773515
Feeling hot 24.01 11.09 36 171200 19336 34766359
T-cell lymphoma 23.96 11.09 27 171209 974 34784721
Cryoglobulinaemia 23.95 11.09 19 171217 436 34785259
Pancreatitis necrotising 23.87 11.09 46 171190 2712 34782983
Mycobacterium marinum infection 23.82 11.09 16 171220 281 34785414
Stomatitis 23.82 11.09 117 171119 42397 34743298
Throat irritation 23.80 11.09 11 171225 10574 34775121
Cyclosporidium infection 23.71 11.09 7 171229 11 34785684
Extranodal marginal zone B-cell lymphoma (MALT type) 23.70 11.09 14 171222 194 34785501
Pleural adhesion 23.70 11.09 14 171222 194 34785501
Lip squamous cell carcinoma 23.70 11.09 12 171224 120 34785575
Mood swings 23.47 11.09 5 171231 7896 34777799
Renal haematoma 23.46 11.09 20 171216 509 34785186
Drug intolerance 23.45 11.09 183 171053 59387 34726308
Sphincter of Oddi dysfunction 23.36 11.09 12 171224 124 34785571
Urosepsis 23.27 11.09 124 171112 12675 34773020
Ureteric anastomosis complication 23.17 11.09 9 171227 44 34785651
Metastatic carcinoma of the bladder 23.16 11.09 14 171222 203 34785492
Obstructive airways disorder 23.14 11.09 25 171211 15469 34770226
Hypocalcaemia 23.13 11.09 53 171183 24236 34761459
Migraine 23.13 11.09 31 171205 17447 34768248
Eye swelling 23.08 11.09 10 171226 9985 34775710
Acarodermatitis 23.06 11.09 18 171218 403 34785292
Hip fracture 23.03 11.09 15 171221 11910 34773785
Mycobacterium haemophilum infection 23.01 11.09 11 171225 96 34785599
Propionibacterium infection 22.95 11.09 15 171221 251 34785444
SARS-CoV-2 antibody test positive 22.95 11.09 18 171218 406 34785289
Lymphangiectasia 22.92 11.09 8 171228 27 34785668
Acquired porokeratosis 22.90 11.09 6 171230 4 34785691
Cell-mediated immune deficiency 22.85 11.09 9 171227 46 34785649
Cutaneous tuberculosis 22.81 11.09 11 171225 98 34785597
Prostatitis 22.78 11.09 69 171167 5438 34780257
Abdominal wall haemorrhage 22.71 11.09 19 171217 471 34785224
Microsporum infection 22.70 11.09 8 171228 28 34785667
Pancreas transplant 22.70 11.09 8 171228 28 34785667
Phospholipidosis 22.69 11.09 9 171227 47 34785648
Chronic papillomatous dermatitis 22.54 11.09 9 171227 48 34785647
Extrapyramidal disorder 22.52 11.09 18 171218 12862 34772833
Eye infection fungal 22.46 11.09 17 171219 363 34785332
Bladder cancer 22.44 11.09 28 171208 16250 34769445
Back disorder 22.43 11.09 3 171233 6648 34779047
Incorrect dose administered 22.41 11.09 112 171124 40403 34745292
Trichophytic granuloma 22.39 11.09 9 171227 49 34785646
Photosensitivity reaction 22.33 11.09 107 171129 10487 34775208
Lymphangitis 22.32 11.09 20 171216 545 34785150
Illness 22.32 11.09 20 171216 13509 34772186
Injection site mass 22.32 11.09 3 171233 6623 34779072
Cardiogenic shock 22.31 11.09 62 171174 26556 34759139
Myelitis 22.28 11.09 24 171212 823 34784872
Cow pox 22.27 11.09 8 171228 30 34785665
Influenza 22.26 11.09 147 171089 49519 34736176
Limbic encephalitis 22.25 11.09 18 171218 425 34785270
Accidental exposure to product 22.25 11.09 18 171218 12784 34772911
Musculoskeletal discomfort 22.21 11.09 6 171230 8062 34777633
Wound 22.18 11.09 24 171212 14840 34770855
Pneumonitis 22.15 11.09 88 171148 33790 34751905
Pollakiuria 22.10 11.09 39 171197 19635 34766060
Abnormal dreams 22.10 11.09 5 171231 7573 34778122
Uraemic encephalopathy 22.04 11.09 16 171220 320 34785375
Encephalitis protozoal 22.02 11.09 7 171229 16 34785679
Necrotising herpetic retinopathy 22.02 11.09 7 171229 16 34785679
Seizure 22.01 11.09 371 170865 104486 34681209
Metabolic acidosis 22 11.09 318 170918 43362 34742333
Septic embolus 21.95 11.09 29 171207 1236 34784459
Gastrointestinal ulcer perforation 21.95 11.09 9 171227 52 34785643
Abdominal pain 21.89 11.09 622 170614 162996 34622699
Immune-mediated adverse reaction 21.87 11.09 20 171216 560 34785135
Vena cava injury 21.87 11.09 16 171220 324 34785371
Cutaneous mucormycosis 21.83 11.09 13 171223 183 34785512
Rhinovirus infection 21.82 11.09 58 171178 4241 34781454
Body temperature increased 21.80 11.09 32 171204 17336 34768359
Surgical procedure repeated 21.77 11.09 17 171219 381 34785314
Product quality issue 21.76 11.09 31 171205 17004 34768691
Complications of transplanted pancreas 21.73 11.09 7 171229 17 34785678
Device malfunction 21.68 11.09 12 171224 10409 34775286
Injection site pruritus 21.62 11.09 4 171232 6979 34778716
Bile output increased 21.62 11.09 5 171231 0 34785695
Retinitis 21.62 11.09 17 171219 385 34785310
Nervousness 21.57 11.09 18 171218 12588 34773107
Wound infection 21.56 11.09 80 171156 6999 34778696
Burkitt's lymphoma 21.55 11.09 11 171225 112 34785583
Knee arthroplasty 21.53 11.09 5 171231 7439 34778256
Haemolytic anaemia 21.48 11.09 105 171131 10374 34775321
Nephrosclerosis 21.45 11.09 25 171211 936 34784759
Gastroenteritis eosinophilic 21.41 11.09 13 171223 190 34785505
Blood immunoglobulin G decreased 21.41 11.09 31 171205 1442 34784253
Speech disorder 21.40 11.09 60 171176 25626 34760069
Herpes oesophagitis 21.25 11.09 12 171224 152 34785543
Acinetobacter bacteraemia 21.18 11.09 12 171224 153 34785542
Chest wall abscess 21.18 11.09 12 171224 153 34785542
Sputum discoloured 21.15 11.09 6 171230 7806 34777889
Infectious pleural effusion 21.14 11.09 41 171195 2429 34783266
Metastasis 21.13 11.09 56 171180 4088 34781607
Wound infection fungal 21.13 11.09 8 171228 36 34785659
Disseminated strongyloidiasis 21.12 11.09 13 171223 195 34785500
Peritonitis 21.11 11.09 145 171091 16220 34769475
Hepatitis cholestatic 21.10 11.09 86 171150 7861 34777834
Lung abscess 21.09 11.09 43 171193 2642 34783053
Chromaturia 21.06 11.09 24 171212 14496 34771199
Diverticulitis intestinal perforated 21.04 11.09 10 171226 86 34785609
Transplant 21.02 11.09 23 171213 803 34784892
Herpes simplex test positive 21.01 11.09 13 171223 197 34785498
Bone marrow transplant 20.92 11.09 26 171210 1042 34784653
Renal adenoma 20.92 11.09 7 171229 20 34785675
Panic attack 20.90 11.09 10 171226 9422 34776273
Enterococcus test positive 20.90 11.09 26 171210 1043 34784652
Seroconversion test negative 20.90 11.09 6 171230 8 34785687
Renal arteriosclerosis 20.89 11.09 13 171223 199 34785496
Pericarditis infective 20.88 11.09 9 171227 60 34785635
Myoclonic dystonia 20.88 11.09 9 171227 60 34785635
Blister 20.87 11.09 51 171185 22807 34762888
Tumour lysis syndrome 20.86 11.09 32 171204 17027 34768668
Petechiae 20.85 11.09 10 171226 9408 34776287
Milk allergy 20.85 11.09 10 171226 88 34785607
Cytomegalovirus gastrointestinal ulcer 20.78 11.09 8 171228 38 34785657
Blood phosphorus increased 20.78 11.09 6 171230 7715 34777980
Urinary incontinence 20.68 11.09 38 171198 18836 34766859
Human herpes virus 8 test positive 20.67 11.09 7 171229 21 34785674
Lymphadenopathy mediastinal 20.64 11.09 41 171195 2472 34783223
Pericarditis constrictive 20.62 11.09 16 171220 355 34785340
Rabies 20.49 11.09 6 171230 9 34785686
Respiratory syncytial virus infection 20.43 11.09 60 171176 4649 34781046
Sinus bradycardia 20.40 11.09 20 171216 12943 34772752
Pneumonia adenoviral 20.39 11.09 16 171220 361 34785334
Swelling 20.21 11.09 123 171113 42243 34743452
Lemierre syndrome 20.19 11.09 7 171229 23 34785672
Tongue necrosis 20.19 11.09 7 171229 23 34785672
Eschar 20.19 11.09 21 171215 691 34785004
Alpha haemolytic streptococcal infection 20.15 11.09 27 171209 1167 34784528
Abdominal infection 20.09 11.09 34 171202 1811 34783884
Bronchospasm 20.05 11.09 14 171222 10717 34774978
Oesophageal squamous cell carcinoma 20.02 11.09 16 171220 371 34785324
Retinal ischaemia 20.02 11.09 16 171220 371 34785324
Schistosomiasis 19.98 11.09 8 171228 43 34785652
Arteriosclerosis coronary artery 19.95 11.09 19 171217 12466 34773229
Sinus tachycardia 19.88 11.09 34 171202 17326 34768369
Hypertensive emergency 19.86 11.09 25 171211 1015 34784680
Ageusia 19.86 11.09 13 171223 10295 34775400
Respiratory tract infection fungal 19.83 11.09 21 171215 706 34784989
Neuralgia 19.80 11.09 27 171209 15086 34770609
Pharyngeal oedema 19.75 11.09 3 171233 6044 34779651
Bronchial anastomosis complication 19.75 11.09 6 171230 11 34785684
IIIrd nerve paralysis 19.69 11.09 18 171218 504 34785191
Second primary malignancy 19.68 11.09 7 171229 7879 34777816
Localised infection 19.63 11.09 35 171201 17552 34768143
Hyperparathyroidism 19.63 11.09 27 171209 1197 34784498
Blood pressure diastolic decreased 19.61 11.09 10 171226 9084 34776611
Vascular anastomotic haemorrhage 19.58 11.09 14 171222 273 34785422
Renal and pancreas transplant rejection 19.54 11.09 7 171229 26 34785669
Arteriovenous fistula thrombosis 19.52 11.09 15 171221 328 34785367
Reactive gastropathy 19.52 11.09 15 171221 328 34785367
Pulmonary thrombosis 19.49 11.09 6 171230 7401 34778294
Necrosis 19.41 11.09 67 171169 5656 34780039
Myasthenia gravis 19.41 11.09 5 171231 6935 34778760
Ureteritis 19.41 11.09 6 171230 12 34785683
Chronic inflammatory demyelinating polyradiculoneuropathy 19.40 11.09 21 171215 724 34784971
Superinfection 19.39 11.09 40 171196 2479 34783216
Impaired work ability 19.37 11.09 5 171231 6925 34778770
Complications of bone marrow transplant 19.37 11.09 13 171223 228 34785467
White blood cell count increased 19.36 11.09 120 171116 41031 34744664
Incisional hernia 19.34 11.09 28 171208 1302 34784393
Eye infection toxoplasmal 19.32 11.09 13 171223 229 34785466
Leuconostoc infection 19.28 11.09 5 171231 3 34785692
Lymphorrhoea 19.28 11.09 9 171227 74 34785621
Roseolovirus test positive 19.28 11.09 9 171227 74 34785621
Viral skin infection 19.26 11.09 8 171228 48 34785647
Hepatic haematoma 19.21 11.09 16 171220 394 34785301
Red blood cell schistocytes present 19.17 11.09 13 171223 232 34785463
Hypoaldosteronism 19.16 11.09 12 171224 186 34785509
Post procedural complication 19.14 11.09 108 171128 11280 34774415
Odynophagia 19.05 11.09 65 171171 5456 34780239
Disseminated Bacillus Calmette-Guerin infection 19.05 11.09 12 171224 188 34785507
Face oedema 19.03 11.09 17 171219 11499 34774196
Prostatic abscess 19.01 11.09 17 171219 462 34785233
Obesity 18.99 11.09 21 171215 12857 34772838
Sebaceous gland disorder 18.95 11.09 7 171229 29 34785666
Gastroenteritis 18.82 11.09 128 171108 14272 34771423
Central nervous system immune reconstitution inflammatory response 18.79 11.09 6 171230 14 34785681
Pneumonia necrotising 18.74 11.09 21 171215 753 34784942
Disseminated trichosporonosis 18.73 11.09 8 171228 52 34785643
Frequent bowel movements 18.69 11.09 21 171215 12766 34772929
Drug level abnormal 18.67 11.09 12 171224 195 34785500
Cardiac valve vegetation 18.65 11.09 17 171219 474 34785221
Encephalomyelitis 18.60 11.09 8 171228 53 34785642
Paraspinal abscess 18.59 11.09 9 171227 81 34785614
Hemianopia heteronymous 18.58 11.09 7 171229 31 34785664
Pneumonia 18.56 11.09 1527 169709 361100 34424595
Hepatitis B 18.55 11.09 68 171168 5915 34779780
Rash maculo-papular 18.53 11.09 74 171162 28377 34757318
Drug effective for unapproved indication 18.50 11.09 40 171196 2562 34783133
Taste disorder 18.46 11.09 6 171230 7149 34778546
Blood creatinine abnormal 18.45 11.09 38 171198 2352 34783343
Pneumocephalus 18.40 11.09 11 171225 156 34785539
Gastritis fungal 18.40 11.09 9 171227 83 34785612
Staphylococcal sepsis 18.33 11.09 96 171140 9748 34775947
Coronary artery occlusion 18.33 11.09 16 171220 10946 34774749
Skin abrasion 18.32 11.09 6 171230 7113 34778582
Intra-abdominal haemorrhage 18.30 11.09 38 171198 2366 34783329
Intraocular pressure increased 18.24 11.09 63 171173 5320 34780375
Fluoride increased 18.23 11.09 8 171228 56 34785639
Gastric ulcer haemorrhage, obstructive 18.23 11.09 6 171230 16 34785679
Argentine haemorrhagic fever 18.23 11.09 6 171230 16 34785679
Cerebral cyst 18.22 11.09 14 171222 306 34785389
Acute disseminated encephalomyelitis 18.22 11.09 9 171227 85 34785610
Multiple sclerosis 18.19 11.09 5 171231 6640 34779055
Pseudohypoaldosteronism 18.18 11.09 5 171231 5 34785690
Nephrocalcinosis 18.17 11.09 19 171217 629 34785066
Immunosuppression 18.17 11.09 70 171166 6234 34779461
Fluid retention 18.11 11.09 69 171167 26818 34758877
Pyuria 18.11 11.09 21 171215 782 34784913
Large intestine perforation 18.01 11.09 86 171150 8417 34777278
Erythropoiesis abnormal 18.00 11.09 12 171224 208 34785487
Euphoric mood 17.97 11.09 3 171233 5638 34780057
Acute coronary syndrome 17.95 11.09 24 171212 13521 34772174
Perineal cyst 17.95 11.09 13 171223 259 34785436
Endocarditis enterococcal 17.86 11.09 9 171227 89 34785606
Eating disorder 17.86 11.09 9 171227 8231 34777464
Nephritis 17.79 11.09 38 171198 2413 34783282
Cataract 17.77 11.09 67 171169 26119 34759576
Oligoarthritis 17.75 11.09 10 171226 126 34785569
Radiculitis brachial 17.71 11.09 6 171230 18 34785677
Oesophageal stenosis 17.68 11.09 31 171205 1699 34783996
Obsessive-compulsive disorder 17.64 11.09 3 171233 5561 34780134
Hospice care 17.59 11.09 6 171230 6934 34778761
Alanine aminotransferase increased 17.59 11.09 284 170952 80531 34705164
Dry skin 17.58 11.09 86 171150 31201 34754494
Splenic rupture 17.58 11.09 29 171207 1512 34784183
Oedematous kidney 17.58 11.09 7 171229 37 34785658
Gastric disorder 17.57 11.09 21 171215 12420 34773275
Angioimmunoblastic T-cell lymphoma 17.51 11.09 14 171222 325 34785370
Infected lymphocele 17.47 11.09 6 171230 19 34785676
Metastatic malignant melanoma 17.45 11.09 34 171202 2021 34783674
Microtia 17.40 11.09 13 171223 272 34785423
Renal vessel disorder 17.37 11.09 12 171224 221 34785474
Resting tremor 17.37 11.09 19 171217 663 34785032
Oedema 17.32 11.09 142 171094 45599 34740096
Interferon gamma decreased 17.30 11.09 4 171232 0 34785695
Cystitis glandularis 17.30 11.09 4 171232 0 34785695
Pneumonia proteus 17.28 11.09 5 171231 7 34785688
Small intestine gangrene 17.28 11.09 5 171231 7 34785688
Cytomegalovirus myocarditis 17.28 11.09 5 171231 7 34785688
Hyperglycaemic hyperosmolar nonketotic syndrome 17.25 11.09 26 171210 1254 34784441
Abscess 17.25 11.09 108 171128 11709 34773986
Biliary anastomosis 17.24 11.09 6 171230 20 34785675
T-cell lymphoma stage IV 17.22 11.09 10 171226 134 34785561
Peripheral coldness 17.15 11.09 7 171229 7244 34778451
Pseudomonal sepsis 17.15 11.09 47 171189 3500 34782195
Encephalitis fungal 17.05 11.09 11 171225 180 34785515
Myocarditis infectious 17.02 11.09 6 171230 21 34785674
Brucellosis 17.02 11.09 6 171230 21 34785674
Contraindicated product prescribed 16.95 11.09 15 171221 402 34785293
Tooth infection 16.91 11.09 6 171230 6765 34778930
Tooth disorder 16.88 11.09 17 171219 10865 34774830
Blood creatine increased 16.83 11.09 58 171178 4893 34780802
Sexual dysfunction 16.78 11.09 5 171231 6298 34779397
Neutrophil morphology abnormal 16.72 11.09 8 171228 70 34785625
Segmented hyalinising vasculitis 16.71 11.09 7 171229 43 34785652
Leukoencephalopathy 16.68 11.09 52 171184 4163 34781532
Hepatic infection fungal 16.63 11.09 11 171225 188 34785507
Varicella virus test positive 16.62 11.09 8 171228 71 34785624
Restrictive allograft syndrome 16.60 11.09 6 171230 23 34785672
Adenovirus test positive 16.58 11.09 7 171229 44 34785651
Phaeohyphomycotic brain abscess 16.58 11.09 7 171229 44 34785651
Thirst 16.56 11.09 9 171227 7886 34777809
Erythema multiforme 16.54 11.09 11 171225 8638 34777057
Hernial eventration 16.52 11.09 8 171228 72 34785623
Nocardia sepsis 16.52 11.09 5 171231 9 34785686
Arteriovenous fistula aneurysm 16.52 11.09 5 171231 9 34785686
Sinus disorder 16.50 11.09 7 171229 7078 34778617
Hepatitis infectious mononucleosis 16.45 11.09 7 171229 45 34785650
Viral sepsis 16.43 11.09 9 171227 107 34785588
Musculoskeletal disorder 16.37 11.09 5 171231 6199 34779496
Capnocytophaga infection 16.36 11.09 9 171227 108 34785587
Intestinal metastasis 16.36 11.09 12 171224 244 34785451
Gastroenteritis rotavirus 16.34 11.09 11 171225 194 34785501
Procedural pneumothorax 16.32 11.09 7 171229 46 34785649
Tuberculosis of central nervous system 16.24 11.09 11 171225 196 34785499
Gastrointestinal toxicity 16.22 11.09 39 171197 2680 34783015
Melaena 16.21 11.09 104 171132 35276 34750419
Ventricular extrasystoles 16.20 11.09 21 171215 11987 34773708
Emphysematous cholecystitis 16.20 11.09 7 171229 47 34785648
Bronchopneumopathy 16.16 11.09 16 171220 496 34785199
Mental impairment 16.16 11.09 16 171220 10306 34775389
Cytomegalovirus mucocutaneous ulcer 16.15 11.09 8 171228 76 34785619
Prescribed overdose 16.10 11.09 17 171219 10630 34775065
Granulocytopenia 16.10 11.09 6 171230 6561 34779134
Pneumonia acinetobacter 16.08 11.09 9 171227 112 34785583
Blood test abnormal 16.06 11.09 7 171229 6964 34778731
Splenic vein thrombosis 16.05 11.09 16 171220 500 34785195
Lactic acidosis 16.04 11.09 102 171134 34670 34751025
Blood glucose decreased 16.02 11.09 25 171211 13212 34772483
Unresponsive to stimuli 15.95 11.09 75 171161 27494 34758201
Hepatitis viral 15.94 11.09 17 171219 576 34785119
Escherichia sepsis 15.90 11.09 55 171181 4649 34781046
Adhesiolysis 15.86 11.09 5 171231 11 34785684
Transmission of an infectious agent via transplant 15.86 11.09 5 171231 11 34785684
Status epilepticus 15.82 11.09 111 171125 12503 34773192
Ectropion 15.80 11.09 9 171227 116 34785579
Cholelithiasis 15.76 11.09 52 171184 21096 34764599
Eosinophilic oesophagitis 15.75 11.09 13 171223 316 34785379
Joint stiffness 15.74 11.09 18 171218 10855 34774840
Reticulocytopenia 15.74 11.09 9 171227 117 34785578
NPM1 gene mutation 15.74 11.09 9 171227 117 34785578
Laryngeal mass 15.67 11.09 6 171230 28 34785667
Left ventricular hypertrophy 15.63 11.09 80 171156 8050 34777645
Mesangioproliferative glomerulonephritis 15.60 11.09 7 171229 52 34785643
Oral pain 15.59 11.09 18 171218 10809 34774886
Dermatitis allergic 15.51 11.09 7 171229 6823 34778872
Pyogenic granuloma 15.44 11.09 12 171224 267 34785428
Artery dissection 15.41 11.09 9 171227 122 34785573
Middle insomnia 15.40 11.09 7 171229 6795 34778900
Toothache 15.38 11.09 6 171230 6382 34779313
Graft haemorrhage 15.38 11.09 7 171229 54 34785641
Sinusitis bacterial 15.36 11.09 15 171221 457 34785238
Acute generalised exanthematous pustulosis 15.30 11.09 7 171229 6769 34778926
Pneumonia viral 15.29 11.09 42 171194 3132 34782563
Bone tuberculosis 15.28 11.09 14 171222 393 34785302
Choking 15.26 11.09 3 171233 5012 34780683
Large intestine infection 15.25 11.09 27 171209 1491 34784204
Capillary leak syndrome 15.24 11.09 34 171202 2224 34783471
Renal abscess 15.21 11.09 12 171224 273 34785422
Cushingoid 15.21 11.09 38 171198 2676 34783019
Parainfluenzae virus infection 15.21 11.09 39 171197 2791 34782904
Appendicitis 15.19 11.09 31 171205 14776 34770919
Dyschromatopsia 15.16 11.09 14 171222 397 34785298
Q fever 15.16 11.09 9 171227 126 34785569
Muscle spasticity 15.08 11.09 5 171231 5883 34779812
Skin exfoliation 15.07 11.09 76 171160 27356 34758339
Disseminated varicella 15.07 11.09 4 171232 3 34785692
Oesophageal compression 15.07 11.09 4 171232 3 34785692
Cytokine storm 15.07 11.09 18 171218 692 34785003
Myocarditis toxoplasmal 15.06 11.09 7 171229 57 34785638
Escherichia test positive 15.02 11.09 23 171213 1125 34784570
Metastases to salivary gland 15.01 11.09 5 171231 14 34785681
Genital disorder 15.01 11.09 5 171231 14 34785681
Oral papilloma 15.01 11.09 5 171231 14 34785681
Prescribed underdose 14.98 11.09 13 171223 8920 34776775
Blood cholesterol increased 14.98 11.09 51 171185 20492 34765203
Potentiating drug interaction 14.95 11.09 56 171180 4921 34780774
Depressed level of consciousness 14.88 11.09 136 171100 42705 34742990
Subcutaneous abscess 14.83 11.09 47 171189 3796 34781899
Neoplasm malignant 14.80 11.09 49 171187 19856 34765839
Urine output decreased 14.77 11.09 92 171144 9957 34775738
Spontaneous intrahepatic portosystemic venous shunt 14.76 11.09 5 171231 15 34785680
Severe acute respiratory syndrome 14.75 11.09 7 171229 60 34785635
Device related bacteraemia 14.74 11.09 14 171222 412 34785283
Therapeutic response shortened 14.73 11.09 9 171227 7395 34778300
Erythrophagocytosis 14.73 11.09 6 171230 34 34785661
Bone disorder 14.70 11.09 6 171230 6209 34779486
Hepatitis A 14.68 11.09 15 171221 483 34785212
Myopathy 14.68 11.09 102 171134 11452 34774243
Gingival bleeding 14.65 11.09 8 171228 6992 34778703
Epstein-Barr virus antibody positive 14.63 11.09 12 171224 289 34785406
Acute hepatitis C 14.61 11.09 8 171228 95 34785600
Sudden death 14.61 11.09 33 171203 15168 34770527
Polyneuropathy 14.60 11.09 32 171204 14864 34770831
Clostridial infection 14.59 11.09 45 171191 3582 34782113
Fungating wound 14.58 11.09 6 171230 35 34785660
Cardiac autonomic neuropathy 14.55 11.09 7 171229 62 34785633
Norovirus test positive 14.55 11.09 7 171229 62 34785633
Pneumonia staphylococcal 14.55 11.09 40 171196 2984 34782711
Insulin resistant diabetes 14.54 11.09 4 171232 4 34785691
Blood iron decreased 14.54 11.09 4 171232 5309 34780386
Psoriasis 14.46 11.09 121 171115 38691 34747004
Urine protein/creatinine ratio increased 14.45 11.09 16 171220 566 34785129
Pneumonia mycoplasmal 14.45 11.09 17 171219 643 34785052
Microangiopathic haemolytic anaemia 14.45 11.09 20 171216 892 34784803
Vocal cord thickening 14.44 11.09 6 171230 36 34785659
Sweat gland tumour 14.38 11.09 14 171222 425 34785270
Ill-defined disorder 14.37 11.09 29 171207 13880 34771815
Red cell distribution width increased 14.34 11.09 6 171230 6117 34779578
Bradyphrenia 14.33 11.09 3 171233 4795 34780900
Cranial nerve paralysis 14.31 11.09 6 171230 37 34785658
Acute allograft nephropathy 14.31 11.09 6 171230 37 34785658
Osteomyelitis chronic 14.29 11.09 12 171224 299 34785396
Dialysis 14.28 11.09 99 171137 11109 34774586
Hiccups 14.26 11.09 17 171219 10065 34775630
HLA marker study positive 14.26 11.09 8 171228 100 34785595
Vascular compression 14.25 11.09 13 171223 363 34785332
Breath sounds abnormal 14.20 11.09 8 171228 6873 34778822
Tuberculosis 14.19 11.09 81 171155 8496 34777199
Keloid scar 14.17 11.09 6 171230 38 34785657
Malabsorption 14.13 11.09 34 171202 2338 34783357
Genitourinary tract infection 14.12 11.09 8 171228 102 34785593
Rotator cuff syndrome 14.12 11.09 5 171231 5644 34780051
Pleural effusion 14.09 11.09 510 170726 81036 34704659
Renal cell carcinoma stage I 14.08 11.09 5 171231 18 34785677
Inhibin B 14.08 11.09 5 171231 18 34785677
Exercise tolerance decreased 14.06 11.09 4 171232 5194 34780501
Quadriplegia 14.05 11.09 29 171207 1798 34783897
Metastases to skin 14.03 11.09 14 171222 438 34785257
Granulomatous rosacea 13.96 11.09 9 171227 147 34785548
Sinus congestion 13.94 11.09 5 171231 5600 34780095
Ankylosing spondylitis 13.94 11.09 5 171231 5599 34780096
Skin plaque 13.93 11.09 52 171184 4562 34781133
Dyslipidaemia 13.93 11.09 73 171163 7415 34778280
Gastroduodenal ulcer 13.90 11.09 13 171223 375 34785320
Splenic peliosis 13.87 11.09 5 171231 19 34785676
Infective aortitis 13.87 11.09 5 171231 19 34785676
Acquired macroglossia 13.87 11.09 5 171231 19 34785676
B-lymphocyte abnormalities 13.87 11.09 5 171231 19 34785676
Peritoneal candidiasis 13.87 11.09 5 171231 19 34785676
Tuberculosis of genitourinary system 13.87 11.09 5 171231 19 34785676
Mood altered 13.87 11.09 14 171222 8938 34776757
Alcohol abuse 13.87 11.09 3 171233 4687 34781008
Psychotic disorder 13.86 11.09 67 171169 24385 34761310
Wound evisceration 13.86 11.09 8 171228 106 34785589
Skin mass 13.82 11.09 47 171189 3938 34781757
Amyloidosis senile 13.79 11.09 6 171230 41 34785654
Biliary ischaemia 13.79 11.09 6 171230 41 34785654
Intracranial infection 13.79 11.09 6 171230 41 34785654
Bundle branch block left 13.78 11.09 6 171230 5973 34779722
Haemolysis 13.76 11.09 77 171159 8017 34777678
Viral load increased 13.76 11.09 35 171201 2492 34783203
Leiomyosarcoma 13.75 11.09 9 171227 151 34785544
Lymph node tuberculosis 13.70 11.09 14 171222 451 34785244
Granulomatous liver disease 13.69 11.09 16 171220 601 34785094
Myelodysplastic syndrome unclassifiable 13.67 11.09 5 171231 20 34785675
Lymphadenitis fungal 13.66 11.09 4 171232 6 34785689
Oesophageal candidiasis 13.66 11.09 50 171186 4346 34781349
Bacteriuria 13.64 11.09 12 171224 319 34785376
Red blood cell count decreased 13.59 11.09 85 171151 29005 34756690
Hypoproteinaemia 13.57 11.09 32 171204 2172 34783523
Anorectal varices 13.55 11.09 6 171230 43 34785652
Gynaecomastia 13.53 11.09 18 171218 10162 34775533
Circulatory collapse 13.53 11.09 55 171181 20983 34764712
Ocular hyperaemia 13.51 11.09 22 171214 11430 34774265
Refractoriness to platelet transfusion 13.49 11.09 7 171229 74 34785621
No adverse event 13.48 11.09 62 171174 22865 34762830
Pneumococcal infection 13.48 11.09 14 171222 460 34785235
Peripheral T-cell lymphoma unspecified 13.48 11.09 14 171222 460 34785235
Seasonal allergy 13.44 11.09 8 171228 6667 34779028
Tendonitis 13.37 11.09 15 171221 9125 34776570
Blood pressure abnormal 13.35 11.09 12 171224 8094 34777601
Crying 13.32 11.09 6 171230 5856 34779839
Type 3 diabetes mellitus 13.29 11.09 5 171231 22 34785673
Vascular graft complication 13.29 11.09 8 171228 115 34785580
Carotid artery perforation 13.28 11.09 4 171232 7 34785688
Endocarditis viral 13.28 11.09 4 171232 7 34785688
St. Louis encephalitis 13.28 11.09 4 171232 7 34785688
Malacoplakia vesicae 13.28 11.09 4 171232 7 34785688
Vestibular nystagmus 13.28 11.09 4 171232 7 34785688
Seborrhoeic keratosis 13.28 11.09 23 171213 1248 34784447
Disseminated toxoplasmosis 13.25 11.09 7 171229 77 34785618
Glomerular vascular disorder 13.23 11.09 8 171228 116 34785579
Lung adenocarcinoma stage IV 13.23 11.09 8 171228 116 34785579
Foot deformity 13.22 11.09 3 171233 4534 34781161
Bladder transitional cell carcinoma stage III 13.21 11.09 6 171230 46 34785649
Lipase increased 13.19 11.09 16 171220 9400 34776295
Stenotrophomonas bacteraemia 13.17 11.09 7 171229 78 34785617
Hypertrophic osteoarthropathy 13.17 11.09 7 171229 78 34785617
B-lymphocyte count decreased 13.16 11.09 16 171220 627 34785068
Pulmonary congestion 13.14 11.09 30 171206 13735 34771960
Urethral stenosis 13.13 11.09 19 171217 883 34784812
Necrotising fasciitis fungal 13.12 11.09 5 171231 23 34785672
Adenovirus reactivation 13.12 11.09 10 171226 216 34785479
Brain oedema 13.11 11.09 114 171122 13707 34771988
Anastomotic haemorrhage 13.11 11.09 9 171227 164 34785531
Acute pulmonary histoplasmosis 13.11 11.09 9 171227 164 34785531
Septic pulmonary embolism 13.10 11.09 6 171230 47 34785648
Intussusception 13.10 11.09 16 171220 630 34785065
Drug ineffective 13.09 11.09 2482 168754 454269 34331426
Alopecia 13.08 11.09 68 171168 24287 34761408
Red blood cells urine positive 13.08 11.09 28 171208 1781 34783914
Papilloma 13.07 11.09 11 171225 275 34785420
Glomerulonephritis minimal lesion 13.07 11.09 14 171222 477 34785218
Nosocomial infection 13.04 11.09 22 171214 1169 34784526
Uveitis 13.02 11.09 72 171164 7463 34778232
Vascular pseudoaneurysm ruptured 13.02 11.09 7 171229 80 34785615
Product administration error 13.02 11.09 39 171197 16305 34769390
Disseminated varicella zoster vaccine virus infection 12.99 11.09 6 171230 48 34785647
Coordination abnormal 12.97 11.09 11 171225 7633 34778062
Bile duct cancer recurrent 12.97 11.09 3 171233 0 34785695
Conjunctival neoplasm 12.97 11.09 3 171233 0 34785695
Small intestine transplant 12.97 11.09 3 171233 0 34785695
Leukoencephalomyelitis 12.97 11.09 3 171233 0 34785695
High grade B-cell lymphoma Burkitt-like lymphoma stage IV 12.97 11.09 3 171233 0 34785695
Retroperitoneal effusion 12.97 11.09 3 171233 0 34785695
Aeromonas test positive 12.97 11.09 3 171233 0 34785695
Pulmonary sensitisation 12.97 11.09 3 171233 0 34785695
Exserohilum infection 12.97 11.09 3 171233 0 34785695
Optic pathway injury 12.97 11.09 3 171233 0 34785695
Sarcomatoid carcinoma 12.97 11.09 3 171233 0 34785695
Multivisceral transplantation 12.97 11.09 3 171233 0 34785695
Giant cell myocarditis 12.97 11.09 3 171233 0 34785695
Renal vascular resistance increased 12.97 11.09 3 171233 0 34785695
Narrow anterior chamber angle 12.94 11.09 8 171228 121 34785574
Hepatitis G 12.94 11.09 4 171232 8 34785687
T-cell type acute leukaemia 12.94 11.09 8 171228 121 34785574
Skin graft rejection 12.94 11.09 4 171232 8 34785687
Intestinal ulcer 12.88 11.09 19 171217 899 34784796
Respiratory tract congestion 12.87 11.09 7 171229 6132 34779563
Molluscum contagiosum 12.87 11.09 11 171225 281 34785414
Incoherent 12.86 11.09 3 171233 4449 34781246
Onychomycosis 12.82 11.09 33 171203 2367 34783328
Papule 12.79 11.09 47 171189 4092 34781603
Page kidney 12.79 11.09 6 171230 50 34785645
Cardiac index increased 12.78 11.09 5 171231 25 34785670
Cardiomyopathy 12.75 11.09 41 171195 16767 34768928
Renal tubular dysfunction 12.72 11.09 13 171223 419 34785276
Fracture 12.71 11.09 9 171227 6840 34778855
Pulmonary cavitation 12.69 11.09 19 171217 911 34784784
Precursor T-lymphoblastic lymphoma/leukaemia 12.69 11.09 6 171230 51 34785644
Hyperoxaluria 12.66 11.09 8 171228 126 34785569
Anorectal infection bacterial 12.62 11.09 4 171232 9 34785686
Tropical spastic paresis 12.62 11.09 4 171232 9 34785686
High-grade B-cell lymphoma 12.61 11.09 8 171228 127 34785568
Decreased activity 12.58 11.09 3 171233 4384 34781311
Enterobacter pneumonia 12.58 11.09 7 171229 86 34785609
Cardiac failure chronic 12.58 11.09 12 171224 7867 34777828
Citrobacter infection 12.56 11.09 14 171222 499 34785196
Haemorrhagic pneumonia 12.55 11.09 8 171228 128 34785567
Toxic encephalopathy 12.54 11.09 55 171181 5194 34780501
Lower respiratory tract infection 12.54 11.09 97 171139 31540 34754155
Platelet count increased 12.50 11.09 17 171219 9509 34776186
Arm amputation 12.44 11.09 8 171228 130 34785565
Tonsil cancer 12.43 11.09 21 171215 1117 34784578
Metastases to lymph nodes 12.42 11.09 51 171185 4677 34781018
Arteritis 12.41 11.09 12 171224 361 34785334
Infusion site extravasation 12.40 11.09 3 171233 4341 34781354
Endothelial dysfunction 12.39 11.09 6 171230 54 34785641
Pneumonia legionella 12.38 11.09 28 171208 1849 34783846
Colon dysplasia 12.34 11.09 8 171228 132 34785563
Food interaction 12.34 11.09 19 171217 934 34784761
Tonsillar neoplasm 12.33 11.09 4 171232 10 34785685
Lacrimation increased 12.32 11.09 14 171222 8468 34777227
Asymptomatic viral hepatitis 12.32 11.09 5 171231 28 34785667
Penile ulceration 12.30 11.09 14 171222 511 34785184
Hepatitis B surface antigen positive 12.29 11.09 8 171228 133 34785562
Disability 12.29 11.09 4 171232 4761 34780934
Normocytic anaemia 12.28 11.09 32 171204 2312 34783383
Weight fluctuation 12.27 11.09 5 171231 5180 34780515
Malignant ascites 12.27 11.09 13 171223 437 34785258
Giardiasis 12.27 11.09 11 171225 300 34785395
Movement disorder 12.26 11.09 26 171210 12222 34773473
Inflammatory marker increased 12.25 11.09 53 171183 4975 34780720
Rash macular 12.25 11.09 28 171208 12814 34772881
Renal haemorrhage 12.24 11.09 24 171212 1433 34784262
Extrapulmonary tuberculosis 12.24 11.09 7 171229 91 34785604
Splenic infection fungal 12.17 11.09 7 171229 92 34785603
Pneumonia herpes viral 12.17 11.09 7 171229 92 34785603
Tooth extraction 12.14 11.09 4 171232 4724 34780971
Splenic haemorrhage 12.13 11.09 13 171223 443 34785252
Atrial septal defect 12.11 11.09 11 171225 7381 34778314
Parvimonas micra infection 12.06 11.09 4 171232 11 34785684
Oesophageal tuberculosis 12.06 11.09 4 171232 11 34785684
Retinal scar 12.06 11.09 11 171225 307 34785388
Jejunal perforation 12.05 11.09 10 171226 245 34785450
Eyelid oedema 12.03 11.09 5 171231 5119 34780576
Endocarditis bacterial 12.01 11.09 19 171217 956 34784739
Tendon rupture 12.01 11.09 10 171226 7002 34778693
Sinus node dysfunction 12.00 11.09 3 171233 4246 34781449
Pharyngeal abscess 11.94 11.09 13 171223 451 34785244
Delirium 11.90 11.09 148 171088 43843 34741852
Device dislocation 11.88 11.09 8 171228 6241 34779454
Blood pressure ambulatory increased 11.85 11.09 6 171230 60 34785635
Staphylococcal skin infection 11.82 11.09 18 171218 876 34784819
Ovarian cancer metastatic 11.81 11.09 4 171232 12 34785683
T-lymphocyte count abnormal 11.81 11.09 4 171232 12 34785683
Gastric perforation 11.80 11.09 33 171203 2487 34783208
Paraesthesia oral 11.79 11.09 3 171233 4194 34781501
Incontinence 11.78 11.09 7 171229 5840 34779855
Necrotising colitis 11.78 11.09 20 171216 1068 34784627
Pleomorphic malignant fibrous histiocytoma 11.77 11.09 5 171231 32 34785663
Myeloma cast nephropathy 11.76 11.09 6 171230 61 34785634
Angiopathy 11.75 11.09 46 171190 4127 34781568
Immune thrombocytopenia 11.75 11.09 81 171155 9071 34776624
Metastases to abdominal wall 11.73 11.09 7 171229 99 34785596
Genital herpes 11.71 11.09 15 171221 620 34785075
Internal haemorrhage 11.71 11.09 5 171231 5036 34780659
Blood urine present 11.70 11.09 22 171214 10812 34774883
Subcutaneous emphysema 11.69 11.09 21 171215 1173 34784522
Peripheral vascular disorder 11.69 11.09 5 171231 5031 34780664
Biliary dilatation 11.68 11.09 19 171217 979 34784716
Muscle rigidity 11.68 11.09 21 171215 10497 34775198
Fibrosis 11.67 11.09 33 171203 2503 34783192
Periodontitis 11.65 11.09 28 171208 1924 34783771
Removal of renal transplant 11.64 11.09 5 171231 33 34785662
Mycobacterium kansasii infection 11.63 11.09 11 171225 322 34785373
Fungal test positive 11.60 11.09 14 171222 544 34785151
Bowen's disease 11.60 11.09 8 171228 147 34785548
Sebaceous hyperplasia 11.60 11.09 6 171230 63 34785632
Transfusion 11.59 11.09 15 171221 8570 34777125
Blood 25-hydroxycholecalciferol decreased 11.59 11.09 10 171226 259 34785436
Abdominal rebound tenderness 11.57 11.09 4 171232 13 34785682
Superinfection viral 11.57 11.09 4 171232 13 34785682
Iliac artery disease 11.57 11.09 4 171232 13 34785682
Product dispensing error 11.55 11.09 61 171175 6213 34779482
Eosinophil count increased 11.55 11.09 15 171221 8557 34777138
Acid fast bacilli infection 11.55 11.09 7 171229 102 34785593
Priapism 11.53 11.09 5 171231 4989 34780706
Inappropriate antidiuretic hormone secretion 11.48 11.09 104 171132 12649 34773046
Diffuse large B-cell lymphoma stage IV 11.46 11.09 10 171226 263 34785432
Apoptosis 11.44 11.09 12 171224 399 34785296
Vanishing bile duct syndrome 11.40 11.09 19 171217 999 34784696
Lung squamous cell carcinoma stage IV 11.39 11.09 5 171231 35 34785660
Sebaceous adenoma 11.39 11.09 5 171231 35 34785660
T-cell lymphoma recurrent 11.39 11.09 5 171231 35 34785660
Cutaneous leishmaniasis 11.36 11.09 9 171227 206 34785489
Intestinal adenocarcinoma 11.36 11.09 6 171230 66 34785629
Anal incontinence 11.35 11.09 13 171223 7836 34777859
Haematocrit decreased 11.30 11.09 102 171134 32114 34753581
Cerebral ventricle collapse 11.28 11.09 6 171230 67 34785628
Ureteric obstruction 11.27 11.09 21 171215 1207 34784488
Aspergillus test positive 11.26 11.09 13 171223 482 34785213
Tonsillar hypertrophy 11.25 11.09 16 171220 732 34784963
Respiratory distress 11.25 11.09 241 170995 35424 34750271
Vertigo 11.23 11.09 76 171160 25460 34760235
Infertility 11.22 11.09 9 171227 210 34785485
Optic discs blurred 11.20 11.09 6 171230 68 34785627
Hyperviscosity syndrome 11.18 11.09 9 171227 211 34785484
Foetal exposure during pregnancy 11.14 11.09 126 171110 37975 34747720
Anti-GAD antibody positive 11.14 11.09 4 171232 15 34785680
Back injury 11.14 11.09 3 171233 4038 34781657
Renal necrosis 11.10 11.09 8 171228 158 34785537
Cytomegalovirus syndrome 11.09 11.09 7 171229 110 34785585

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Transplant rejection 6652.02 10.46 2512 274361 16925 79450590
Cytomegalovirus infection 4684.50 10.46 2486 274387 40158 79427357
Post transplant lymphoproliferative disorder 4469.30 10.46 1631 275242 9833 79457682
Thrombotic microangiopathy 3170.24 10.46 1500 275373 18669 79448846
Immunosuppressant drug level increased 3167.87 10.46 1189 275684 7838 79459677
Polyomavirus-associated nephropathy 2839.01 10.46 970 275903 4657 79462858
Kidney transplant rejection 2457.19 10.46 1025 275848 9221 79458294
Product use in unapproved indication 2307.62 10.46 3536 273337 246823 79220692
Transplant dysfunction 2020.76 10.46 807 276066 6414 79461101
Complications of transplanted kidney 1944.60 10.46 758 276115 5608 79461907
Cytomegalovirus viraemia 1927.35 10.46 925 275948 11896 79455619
BK virus infection 1908.97 10.46 820 276053 7984 79459531
Epstein-Barr virus infection 1728.65 10.46 892 275981 13524 79453991
Acute graft versus host disease 1680.03 10.46 783 276090 9384 79458131
Graft versus host disease 1572.64 10.46 849 276024 14177 79453338
Nocardiosis 1514.15 10.46 613 276260 5066 79462449
Liver transplant rejection 1460.93 10.46 514 276359 2734 79464781
Drug level increased 1360.90 10.46 1117 275756 38534 79428981
Aspergillus infection 1279.56 10.46 809 276064 18352 79449163
COVID-19 1262.99 10.46 2091 274782 155583 79311932
Posterior reversible encephalopathy syndrome 1245.50 10.46 897 275976 25384 79442131
Fatigue 1209.10 10.46 884 275989 928843 78538672
Drug interaction 1112.72 10.46 3565 273308 411618 79055897
Chronic graft versus host disease 1104.09 10.46 517 276356 6264 79461251
Renal impairment 1060.64 10.46 1937 274936 155846 79311669
Mucormycosis 1052.78 10.46 537 276336 7932 79459583
Nephropathy toxic 1050.94 10.46 733 276140 19686 79447829
Bronchopulmonary aspergillosis 986.29 10.46 730 276143 21564 79445951
Adenovirus infection 964.82 10.46 506 276367 7941 79459574
Multiple organ dysfunction syndrome 964.22 10.46 1596 275277 118650 79348865
Off label use 955.08 10.46 5882 270991 901333 78566182
Transplant failure 939.84 10.46 412 276461 4229 79463286
Pneumocystis jirovecii pneumonia 939.82 10.46 830 276043 31678 79435837
Acute graft versus host disease in skin 878.27 10.46 460 276413 7198 79460317
Pain 871.52 10.46 702 276171 703100 78764415
Arthralgia 853.94 10.46 462 276411 571341 78896174
Phaeohyphomycosis 844.56 10.46 266 276607 931 79466584
Dizziness 834.48 10.46 393 276480 526048 78941467
Delayed graft function 821.07 10.46 345 276528 3162 79464353
Chronic allograft nephropathy 808.77 10.46 281 276592 1430 79466085
Klebsiella infection 805.87 10.46 563 276310 15157 79452358
Fall 805.74 10.46 343 276530 487286 78980229
Cytomegalovirus infection reactivation 803.40 10.46 453 276420 8263 79459252
Renal transplant failure 786.48 10.46 283 276590 1624 79465891
Enterococcal infection 782.19 10.46 552 276321 15108 79452407
Immunosuppressant drug level decreased 769.07 10.46 282 276591 1722 79465793
Acute kidney injury 764.67 10.46 3694 273179 515710 78951805
Completed suicide 741.29 10.46 25 276848 245742 79221773
Polyomavirus viraemia 714.06 10.46 256 276617 1451 79466064
Septic shock 708.15 10.46 1413 275460 121388 79346127
Dyspnoea 706.33 10.46 1184 275689 855841 78611674
Nausea 704.25 10.46 1418 275455 955778 78511737
Graft versus host disease in skin 697.03 10.46 365 276508 5708 79461807
Diffuse large B-cell lymphoma 676.77 10.46 458 276415 11691 79455824
Parvovirus B19 infection 668.60 10.46 235 276638 1245 79466270
Joint swelling 666.30 10.46 103 276770 288543 79178972
Escherichia infection 665.47 10.46 530 276343 17487 79450028
Epstein-Barr viraemia 653.77 10.46 257 276616 1948 79465567
Focal segmental glomerulosclerosis 640.80 10.46 285 276588 3036 79464479
Haemophagocytic lymphohistiocytosis 638.02 10.46 561 276312 21276 79446239
Drug hypersensitivity 620.85 10.46 139 276734 298777 79168738
Graft versus host disease in gastrointestinal tract 617.57 10.46 342 276531 6014 79461501
Strongyloidiasis 609.37 10.46 289 276584 3609 79463906
Pseudomonas infection 608.70 10.46 536 276337 20367 79447148
Acute respiratory distress syndrome 600.65 10.46 753 276120 43314 79424201
Leukopenia 596.87 10.46 1277 275596 115236 79352279
Trichodysplasia spinulosa 583.84 10.46 182 276691 610 79466905
Epstein-Barr virus associated lymphoproliferative disorder 577.18 10.46 270 276603 3262 79464253
Cryptococcosis 564.57 10.46 265 276608 3228 79464287
Kidney fibrosis 549.28 10.46 261 276612 3274 79464241
Brain abscess 541.91 10.46 288 276585 4648 79462867
Hypersensitivity 530.51 10.46 129 276744 262110 79205405
Blood creatinine increased 514.64 10.46 1438 275435 153619 79313896
Peripheral swelling 514.40 10.46 149 276724 269468 79198047
Arthropathy 513.72 10.46 24 276849 177087 79290428
Infusion related reaction 507.22 10.46 93 276780 230144 79237371
Drug abuse 507.20 10.46 12 276861 162679 79304836
Malaise 505.63 10.46 574 276299 489295 78978220
Pain in extremity 501.80 10.46 324 276549 364214 79103301
Hepatitis E 493.32 10.46 230 276643 2756 79464759
Respiratory failure 485.19 10.46 1556 275317 179355 79288160
Malacoplakia 485.02 10.46 150 276723 486 79467029
Rash 482.84 10.46 791 276082 577567 78889948
Renal tubular necrosis 481.35 10.46 511 276362 24528 79442987
Pulmonary nocardiosis 479.20 10.46 178 276695 1133 79466382
Graft loss 465.01 10.46 164 276709 879 79466636
JC virus infection 461.84 10.46 239 276634 3642 79463873
Acute graft versus host disease in intestine 455.58 10.46 240 276633 3801 79463714
Cytomegalovirus test positive 447.45 10.46 271 276602 5676 79461839
Post transplant distal limb syndrome 447.00 10.46 139 276734 461 79467054
Varicella zoster virus infection 442.57 10.46 243 276630 4198 79463317
Contraindicated product administered 442.26 10.46 26 276847 157512 79310003
Lung transplant rejection 427.91 10.46 171 276702 1360 79466155
Synovitis 425.83 10.46 24 276849 150710 79316805
Pneumatosis intestinalis 424.25 10.46 269 276604 6128 79461387
Heart transplant rejection 423.24 10.46 169 276704 1341 79466174
Cystitis haemorrhagic 420.63 10.46 307 276566 8865 79458650
Smooth muscle cell neoplasm 420.27 10.46 149 276724 813 79466702
Human polyomavirus infection 418.37 10.46 154 276719 952 79466563
Cytomegalovirus colitis 416.95 10.46 238 276635 4447 79463068
Asthenia 410.13 10.46 718 276155 510971 78956544
Haemolytic uraemic syndrome 403.98 10.46 229 276644 4220 79463295
Aplasia pure red cell 403.27 10.46 281 276592 7529 79459986
Hepatitis C 400.70 10.46 332 276541 11593 79455922
Meningitis cryptococcal 400.30 10.46 210 276663 3296 79464219
Renal tubular atrophy 399.40 10.46 172 276701 1684 79465831
Constipation 394.25 10.46 248 276625 282802 79184713
Pneumonia cytomegaloviral 393.46 10.46 234 276639 4735 79462780
Anxiety 380.13 10.46 194 276679 248318 79219197
Infection reactivation 378.99 10.46 185 276688 2472 79465043
Abdominal discomfort 374.25 10.46 202 276671 250525 79216990
Headache 374.07 10.46 1102 275771 652670 78814845
Back pain 370.83 10.46 307 276566 303873 79163642
Lymphoproliferative disorder 367.10 10.46 234 276639 5381 79462134
Nasopharyngitis 365.34 10.46 214 276659 253667 79213848
Human herpesvirus 8 infection 364.53 10.46 143 276730 1077 79466438
Blastomycosis 358.90 10.46 123 276750 596 79466919
Alternaria infection 357.38 10.46 121 276752 561 79466954
Candida infection 350.94 10.46 540 276333 37674 79429841
Scedosporium infection 344.66 10.46 145 276728 1333 79466182
Ovarian cyst 339.74 10.46 310 276563 12345 79455170
Cryptosporidiosis infection 339.55 10.46 119 276754 624 79466891
Therapeutic product effect decreased 334.40 10.46 79 276794 163784 79303731
Chronic graft versus host disease in skin 332.59 10.46 144 276729 1430 79466085
Venoocclusive liver disease 331.06 10.46 296 276577 11475 79456040
Viraemia 330.85 10.46 173 276700 2696 79464819
Swelling 324.25 10.46 174 276699 216537 79250978
Mycobacterial infection 322.85 10.46 185 276688 3483 79464032
Glossodynia 320.58 10.46 8 276865 103329 79364186
Proteinuria 319.36 10.46 474 276399 32028 79435487
Musculoskeletal stiffness 318.75 10.46 105 276768 174903 79292612
Sepsis 318.22 10.46 1805 275068 267623 79199892
Actinic keratosis 318.09 10.46 220 276653 5822 79461693
Human herpesvirus 6 infection 317.24 10.46 210 276663 5160 79462355
West Nile viral infection 315.49 10.46 122 276751 880 79466635
Renal graft infection 313.67 10.46 104 276769 446 79467069
Epstein-Barr virus infection reactivation 313.39 10.46 146 276727 1746 79465769
Histoplasmosis disseminated 312.32 10.46 156 276717 2197 79465318
Toxoplasmosis 312.08 10.46 163 276710 2534 79464981
Pemphigus 311.66 10.46 7 276866 99575 79367940
Product dose omission issue 310.17 10.46 243 276630 247294 79220221
Lymphocele 307.55 10.46 139 276734 1542 79465973
Syncope 307.50 10.46 119 276754 179330 79288185
Somnolence 305.30 10.46 230 276643 238751 79228764
COVID-19 pneumonia 302.71 10.46 434 276439 28415 79439100
Pathogen resistance 301.32 10.46 307 276566 14035 79453480
Weight increased 299.06 10.46 313 276560 277073 79190442
Diabetes mellitus 296.13 10.46 763 276110 77627 79389888
Neurotoxicity 295.07 10.46 457 276416 32061 79435454
Feeling abnormal 283.86 10.46 99 276774 159100 79308415
Staphylococcal infection 283.54 10.46 626 276247 57669 79409846
Pruritus 283.34 10.46 591 276282 394057 79073458
Squamous cell carcinoma of skin 283.28 10.46 294 276579 13739 79453776
Depression 282.91 10.46 204 276669 216586 79250929
Systemic mycosis 282.68 10.46 152 276721 2514 79465001
Histoplasmosis 279.57 10.46 145 276728 2220 79465295
Disease recurrence 276.43 10.46 526 276347 43583 79423932
Bacteraemia 275.33 10.46 445 276428 32379 79435136
Wound 273.50 10.46 39 276834 116140 79351375
Contusion 269.62 10.46 90 276783 148686 79318829
Fungal infection 266.77 10.46 502 276371 41246 79426269
Progressive multifocal leukoencephalopathy 266.38 10.46 343 276530 20257 79447258
Sinusitis 264.32 10.46 177 276696 195324 79272191
Renal tubular injury 263.39 10.46 121 276752 1398 79466117
Intentional overdose 262.90 10.46 30 276843 105930 79361585
Chest pain 261.28 10.46 359 276514 281945 79185570
Transplantation associated food allergy 260.78 10.46 63 276810 44 79467471
Dermatophytosis 259.31 10.46 87 276786 390 79467125
Mobility decreased 257.08 10.46 55 276818 122120 79345395
Urticaria 255.36 10.46 164 276709 185037 79282478
Pancytopenia 252.91 10.46 1193 275680 164552 79302963
Vaccination failure 252.31 10.46 125 276748 1728 79465787
Squamous cell carcinoma 250.52 10.46 290 276583 15332 79452183
Insomnia 248.45 10.46 291 276582 244879 79222636
Mycobacterium abscessus infection 245.85 10.46 108 276765 1114 79466401
Hypotension 240.80 10.46 757 276116 439560 79027955
Premature delivery 240.31 10.46 349 276524 23118 79444397
Muscle spasms 239.17 10.46 156 276717 174574 79292941
Hyperhidrosis 237.97 10.46 114 276759 151378 79316137
Alveolar proteinosis 237.57 10.46 93 276780 696 79466819
Asthma 234.06 10.46 88 276785 135007 79332508
Vomiting 233.50 10.46 1357 275516 664471 78803044
Injection site pain 231.00 10.46 81 276792 129757 79337758
Complications of transplanted liver 230.26 10.46 77 276796 341 79467174
Tubulointerstitial nephritis 228.62 10.46 447 276426 37788 79429727
Chronic obstructive pulmonary disease 228.28 10.46 18 276855 85401 79382114
Hypoaesthesia 227.22 10.46 174 276699 179178 79288337
Rheumatoid arthritis 227.14 10.46 233 276640 208237 79259278
Acute graft versus host disease in liver 226.91 10.46 118 276755 1817 79465698
Fungal skin infection 225.94 10.46 179 276694 5857 79461658
Drug intolerance 221.91 10.46 359 276514 263760 79203755
Herpes simplex 220.65 10.46 241 276632 11946 79455569
Malignant neoplasm progression 218.75 10.46 99 276774 135891 79331624
Drug level decreased 215.42 10.46 258 276615 14144 79453371
Myocardial infarction 214.31 10.46 194 276679 183935 79283580
Wheezing 214.14 10.46 69 276804 116595 79350920
Atypical haemolytic uraemic syndrome 213.44 10.46 93 276780 939 79466576
Pyelonephritis 211.38 10.46 305 276568 20083 79447432
Blood pressure increased 210.78 10.46 254 276619 211106 79256409
Gastroenteritis norovirus 209.44 10.46 132 276741 2974 79464541
Osmotic demyelination syndrome 208.79 10.46 103 276770 1410 79466105
Ureaplasma infection 208.66 10.46 92 276781 958 79466557
Systemic lupus erythematosus 208.06 10.46 80 276793 121069 79346446
Pancreas transplant rejection 207.76 10.46 67 276806 258 79467257
Renal failure 204.84 10.46 1296 275577 199672 79267843
Stenotrophomonas infection 204.79 10.46 140 276733 3633 79463882
Glomerulonephritis 204.61 10.46 135 276738 3298 79464217
Rhodococcus infection 204.40 10.46 67 276806 275 79467240
Disseminated cryptococcosis 204.12 10.46 108 276765 1726 79465789
Drug resistance 203.78 10.46 452 276421 41761 79425754
Trichophytosis 203.60 10.46 69 276804 321 79467194
Pulmonary mucormycosis 202.63 10.46 93 276780 1072 79466443
Viral haemorrhagic cystitis 200.49 10.46 111 276762 1950 79465565
Fibromyalgia 199.48 10.46 5 276868 64335 79403180
Pneumonia fungal 198.31 10.46 219 276654 10991 79456524
Drug level fluctuating 197.07 10.46 81 276792 698 79466817
Renal tubular acidosis 195.93 10.46 134 276739 3480 79464035
Immune reconstitution inflammatory syndrome 195.72 10.46 241 276632 13600 79453915
Paraesthesia 195.57 10.46 194 276679 176129 79291386
Encephalitis viral 192.67 10.46 117 276756 2462 79465053
Chest discomfort 190.59 10.46 122 276751 137922 79329593
Gait disturbance 189.79 10.46 266 276607 207240 79260275
Angiosarcoma 189.59 10.46 69 276804 411 79467104
Duodenal ulcer perforation 188.62 10.46 10 276863 66201 79401314
Obliterative bronchiolitis 187.61 10.46 122 276751 2906 79464609
Cytomegalovirus enteritis 186.95 10.46 79 276794 735 79466780
Decreased appetite 186.85 10.46 589 276284 341829 79125686
Balance disorder 185.85 10.46 56 276817 98801 79368714
Acne 185.07 10.46 336 276537 26854 79440661
End stage renal disease 184.57 10.46 220 276653 12000 79455515
Renal transplant 183.76 10.46 113 276760 2434 79465081
Complications of transplanted lung 182.99 10.46 67 276806 407 79467108
Malacoplakia gastrointestinal 182.10 10.46 53 276820 130 79467385
Discomfort 180.40 10.46 106 276767 125511 79342004
Hepatic artery thrombosis 179.19 10.46 60 276813 267 79467248
Complications of transplant surgery 178.97 10.46 75 276798 682 79466833
Pneumonia cryptococcal 178.26 10.46 93 276780 1442 79466073
Pericarditis 177.06 10.46 70 276803 104166 79363349
Heart rate increased 176.03 10.46 100 276773 120624 79346891
Abdominal pain upper 175.34 10.46 318 276555 223501 79244014
Organising pneumonia 175.29 10.46 203 276670 10736 79456779
Graft versus host disease in lung 175.10 10.46 78 276795 834 79466681
Enterobacter infection 174.44 10.46 137 276736 4425 79463090
Hydronephrosis 173.53 10.46 256 276617 17198 79450317
Encephalitis 172.68 10.46 234 276639 14526 79452989
Neutrophil Pelger-Huet anomaly present 172.40 10.46 60 276813 307 79467208
Lymphopenia 171.58 10.46 348 276525 30209 79437306
Acinetobacter infection 169.88 10.46 111 276762 2666 79464849
Irritable bowel syndrome 169.49 10.46 12 276861 62229 79405286
Confusional state 169.28 10.46 553 276320 317444 79150071
Drug ineffective for unapproved indication 168.57 10.46 474 276399 50764 79416751
Arthritis 166.30 10.46 96 276777 114784 79352731
Systemic candida 165.95 10.46 157 276716 6549 79460966
IgA nephropathy 165.93 10.46 93 276780 1675 79465840
Palpitations 165.28 10.46 119 276754 126491 79341024
Nephrotic syndrome 165.20 10.46 199 276674 10975 79456540
Death 163.81 10.46 1223 275650 565291 78902224
Memory impairment 163.71 10.46 92 276781 111642 79355873
Dermatitis atopic 163.46 10.46 188 276685 9868 79457647
Helicobacter infection 162.64 10.46 24 276849 69680 79397835
Dry mouth 161.63 10.46 52 276821 87967 79379548
Pneumocystis jirovecii infection 160.92 10.46 109 276764 2785 79464730
Ureteric stenosis 160.69 10.46 84 276789 1308 79466207
Heart rate decreased 159.99 10.46 26 276847 70290 79397225
Glomerulosclerosis 159.66 10.46 78 276795 1044 79466471
Epidermodysplasia verruciformis 158.98 10.46 57 276816 323 79467192
Oxygen saturation decreased 158.62 10.46 129 276744 128918 79338597
Human ehrlichiosis 158.41 10.46 63 276810 494 79467021
Papilloma viral infection 156.75 10.46 89 276784 1645 79465870
Blister 156.34 10.46 112 276761 119364 79348151
Psoriatic arthropathy 156.33 10.46 39 276834 77960 79389555
Osteoarthritis 156.09 10.46 54 276819 87255 79380260
Biliary anastomosis complication 155.91 10.46 47 276826 136 79467379
Suicide attempt 155.85 10.46 47 276826 82885 79384630
Anogenital warts 154.47 10.46 72 276801 862 79466653
Skin papilloma 153.73 10.46 142 276731 5744 79461771
Injection site erythema 153.09 10.46 41 276832 78156 79389359
Complications of transplanted heart 152.92 10.46 55 276818 315 79467200
Loss of consciousness 151.85 10.46 217 276656 167726 79299789
Renal artery stenosis 151.67 10.46 113 276760 3369 79464146
Inappropriate schedule of product administration 151.67 10.46 144 276729 133484 79334031
Pneumonia pseudomonal 151.29 10.46 141 276732 5770 79461745
Lower respiratory tract infection 150.50 10.46 136 276737 129084 79338431
Drug reaction with eosinophilia and systemic symptoms 150.17 10.46 22 276851 64222 79403293
Human herpesvirus 6 encephalitis 149.74 10.46 64 276809 614 79466901
Cerebrovascular accident 148.11 10.46 193 276680 155099 79312416
Musculoskeletal pain 147.49 10.46 86 276787 102268 79365247
Flushing 147.11 10.46 61 276812 88207 79379308
Epstein-Barr virus test positive 146.72 10.46 74 276799 1065 79466450
New onset diabetes after transplantation 146.30 10.46 44 276829 126 79467389
Cytomegalovirus gastrointestinal infection 145.92 10.46 58 276815 454 79467061
Suicidal ideation 145.77 10.46 42 276831 76298 79391217
Hypogammaglobulinaemia 144.99 10.46 201 276672 12750 79454765
Therapeutic product effect incomplete 144.61 10.46 167 276706 141478 79326037
Emphysematous pyelonephritis 144.40 10.46 52 276821 299 79467216
Donor specific antibody present 144.06 10.46 49 276824 231 79467284
Mycoplasma infection 143.58 10.46 65 276808 724 79466791
Acute myeloid leukaemia recurrent 143.38 10.46 108 276765 3275 79464240
Cerebral aspergillosis 143.30 10.46 85 276788 1711 79465804
Encephalopathy 143.24 10.46 537 276336 66860 79400655
Multiple sclerosis relapse 142.81 10.46 4 276869 46529 79420986
Cytomegalovirus chorioretinitis 142.52 10.46 132 276741 5358 79462157
Bradycardia 141.47 10.46 157 276716 135400 79332115
Graft complication 140.41 10.46 63 276810 686 79466829
Mycobacterium avium complex infection 140.02 10.46 121 276752 4479 79463036
Ascites 138.72 10.46 575 276298 74987 79392528
Chronic kidney disease 136.38 10.46 522 276351 65632 79401883
Acanthamoeba infection 136.28 10.46 55 276818 450 79467065
Bacillary angiomatosis 135.91 10.46 46 276827 213 79467302
Toxicity to various agents 135.53 10.46 2135 274738 419405 79048110
Disseminated tuberculosis 135.43 10.46 114 276759 4069 79463446
Epistaxis 135.16 10.46 113 276760 111402 79356113
Drug level above therapeutic 134.97 10.46 159 276714 8564 79458951
Glomerulonephritis membranoproliferative 134.93 10.46 58 276815 565 79466950
Locked-in syndrome 134.86 10.46 61 276812 678 79466837
Polyomavirus test positive 134.73 10.46 44 276829 178 79467337
Bacterial sepsis 134.50 10.46 154 276719 8044 79459471
Angiosarcoma metastatic 134.44 10.46 40 276833 109 79467406
Endophthalmitis 133.94 10.46 137 276736 6291 79461224
Cerebral toxoplasmosis 133.81 10.46 90 276783 2272 79465243
Hepatic enzyme increased 133.77 10.46 270 276603 182340 79285175
Pneumomediastinum 133.52 10.46 107 276766 3560 79463955
Injury 133.33 10.46 51 276822 77445 79390070
Atypical mycobacterial infection 132.60 10.46 80 276793 1663 79465852
Demodicidosis 132.28 10.46 44 276829 191 79467324
Pneumonia klebsiella 132.14 10.46 122 276751 4932 79462583
Graft versus host disease in liver 132.13 10.46 80 276793 1674 79465841
Microsporidia infection 131.04 10.46 65 276808 901 79466614
Cardiac failure congestive 128.72 10.46 184 276689 142218 79325297
Liver abscess 127.91 10.46 130 276743 5924 79461591
Disseminated mucormycosis 127.87 10.46 59 276814 689 79466826
Adenoviral haemorrhagic cystitis 127.43 10.46 53 276820 472 79467043
Kaposi's sarcoma 127.05 10.46 59 276814 700 79466815
General physical health deterioration 126.99 10.46 508 276365 274730 79192785
Cough 126.91 10.46 750 276123 366039 79101476
Engraftment syndrome 126.51 10.46 72 276801 1337 79466178
Haemolytic anaemia 126.12 10.46 224 276649 17596 79449919
Disseminated intravascular coagulation 125.26 10.46 339 276534 35503 79432012
Stress 124.85 10.46 60 276813 79552 79387963
Escherichia bacteraemia 124.46 10.46 133 276740 6429 79461086
C-reactive protein abnormal 124.31 10.46 12 276861 48355 79419160
Nephropathy 124.10 10.46 161 276712 9577 79457938
Wrong technique in product usage process 123.19 10.46 51 276822 73824 79393691
Post procedural bile leak 123.12 10.46 49 276824 385 79467130
Cholangitis 122.16 10.46 184 276689 12592 79454923
Knee arthroplasty 121.73 10.46 7 276866 43241 79424274
Chronic graft versus host disease in liver 121.54 10.46 55 276818 612 79466903
Sedation 120.76 10.46 18 276855 51877 79415638
Pneumoperitoneum 120.27 10.46 94 276779 3014 79464501
Infective aneurysm 119.72 10.46 62 276811 946 79466569
Escherichia urinary tract infection 119.44 10.46 190 276683 13635 79453880
Adverse event 118.95 10.46 31 276842 60183 79407332
Adenoviral hepatitis 118.75 10.46 60 276813 867 79466648
Cytomegalovirus gastritis 116.44 10.46 48 276825 417 79467098
Myalgia 116.10 10.46 299 276574 185342 79282173
Opportunistic infection 115.85 10.46 90 276783 2860 79464655
Cytomegalovirus enterocolitis 115.78 10.46 72 276801 1583 79465932
Periostitis 115.77 10.46 53 276820 607 79466908
Haemodialysis 115.47 10.46 218 276655 17950 79449565
Hypokalaemia 115.14 10.46 202 276671 143838 79323677
Neck pain 115.00 10.46 59 276814 75358 79392157
Migraine 114.48 10.46 82 276791 87411 79380104
Rectal haemorrhage 114.41 10.46 61 276812 76239 79391276
Pneumonia bacterial 114.34 10.46 225 276648 19106 79448409
Blood cholesterol increased 114.16 10.46 75 276798 83645 79383870
Urinary tract infection bacterial 113.98 10.46 126 276747 6330 79461185
Dyspepsia 112.17 10.46 127 276746 108560 79358955
BK polyomavirus test positive 111.89 10.46 35 276838 119 79467396
Encapsulating peritoneal sclerosis 111.71 10.46 56 276817 795 79466720
American trypanosomiasis 110.86 10.46 43 276830 313 79467202
Bacterial pyelonephritis 110.32 10.46 49 276824 520 79466995
Liver transplant 110.31 10.46 104 276769 4319 79463196
Fungal endocarditis 109.89 10.46 50 276823 564 79466951
Bacterial infection 109.45 10.46 296 276577 30984 79436531
Injection site reaction 108.62 10.46 28 276845 54757 79412758
Disseminated varicella zoster virus infection 108.43 10.46 50 276823 583 79466932
Hypoglycaemia 107.83 10.46 116 276757 101478 79366037
Cystitis viral 107.78 10.46 52 276821 676 79466839
Blood pressure fluctuation 107.76 10.46 49 276824 67096 79400419
Autoimmune haemolytic anaemia 107.50 10.46 139 276734 8241 79459274
Ill-defined disorder 107.41 10.46 47 276826 65828 79401687
Weight decreased 107.21 10.46 757 276116 354441 79113074
Dysgeusia 106.35 10.46 33 276840 57144 79410371
Oropharyngeal pain 106.23 10.46 134 276739 109219 79358296
Lung transplant 105.71 10.46 103 276770 4458 79463057
Bile duct stenosis 105.16 10.46 73 276800 1943 79465572
Infection in an immunocompromised host 104.61 10.46 63 276810 1305 79466210
Central nervous system infection 104.23 10.46 63 276810 1314 79466201
Choroiditis 104.06 10.46 63 276810 1318 79466197
Clostridium difficile colitis 103.59 10.46 296 276577 31987 79435528
Central nervous system lymphoma 103.56 10.46 76 276797 2213 79465302
Intestine transplant rejection 103.34 10.46 29 276844 59 79467456
Hot flush 103.29 10.46 31 276842 54846 79412669
Hip arthroplasty 103.11 10.46 5 276868 35751 79431764
Erythema 103.05 10.46 412 276461 222878 79244637
Prophylaxis against transplant rejection 103.02 10.46 29 276844 60 79467455
Passenger lymphocyte syndrome 102.51 10.46 31 276842 91 79467424
Stomatitis 102.42 10.46 223 276650 146534 79320981
Hypertrophic cardiomyopathy 102.06 10.46 76 276797 2264 79465251
Coronavirus infection 101.93 10.46 128 276745 7369 79460146
Bronchitis 101.91 10.46 186 276687 130458 79337057
Venoocclusive disease 101.76 10.46 101 276772 4472 79463043
Nasal congestion 101.14 10.46 71 276802 76481 79391034
Hepatic failure 100.96 10.46 451 276422 60761 79406754
Steroid diabetes 100.24 10.46 89 276784 3417 79464098
Neuropathy peripheral 100.03 10.46 213 276660 141092 79326423
Cat scratch disease 99.08 10.46 41 276832 360 79467155
Tremor 98.72 10.46 963 275910 169120 79298395
Philadelphia positive chronic myeloid leukaemia 98.70 10.46 33 276840 146 79467369
Red blood cell sedimentation rate increased 98.02 10.46 20 276853 45922 79421593
Hyperkalaemia 97.45 10.46 706 276167 113692 79353823
Visceral leishmaniasis 97.12 10.46 56 276817 1067 79466448
Chronic myeloid leukaemia 96.87 10.46 89 276784 3575 79463940
Pain in jaw 96.60 10.46 21 276852 46130 79421385
Gastrooesophageal reflux disease 95.89 10.46 133 276740 104113 79363402
Meningoencephalitis herpetic 94.44 10.46 68 276805 1921 79465594
Cytomegalovirus nephritis 94.43 10.46 31 276842 128 79467387
Guillain-Barre syndrome 94.22 10.46 135 276738 8830 79458685
Pre-eclampsia 93.80 10.46 119 276754 6922 79460593
Illness 93.70 10.46 23 276850 46488 79421027
Cutaneous malacoplakia 93.52 10.46 29 276844 95 79467420
Enterovirus infection 93.44 10.46 67 276806 1880 79465635
Epstein-Barr virus associated lymphoma 93.37 10.46 54 276819 1035 79466480
Optic neuropathy 92.83 10.46 85 276788 3399 79464116
Blood pressure systolic increased 92.70 10.46 59 276814 66927 79400588
Disseminated mycobacterium avium complex infection 92.48 10.46 33 276840 184 79467331
Cytomegalovirus hepatitis 92.48 10.46 48 276825 736 79466779
Hyperammonaemia 92.48 10.46 150 276723 10943 79456572
Staphylococcal bacteraemia 92.21 10.46 158 276715 12060 79455455
Oedema peripheral 91.97 10.46 507 276366 251781 79215734
Oliguria 91.86 10.46 186 276687 16123 79451392
Chronic hepatitis 91.37 10.46 59 276814 1388 79466127
Cytomegalovirus oesophagitis 91.00 10.46 47 276826 713 79466802
Encephalitis cytomegalovirus 90.64 10.46 54 276819 1096 79466419
Pyelonephritis acute 90.24 10.46 108 276765 5915 79461600
Fusarium infection 90.13 10.46 64 276809 1768 79465747
Infectious pleural effusion 89.50 10.46 86 276787 3658 79463857
Osteomyelitis fungal 89.28 10.46 35 276838 263 79467252
Injection site bruising 89.26 10.46 17 276856 40985 79426530
Mycetoma mycotic 89.26 10.46 29 276844 115 79467400
Klebsiella bacteraemia 89.24 10.46 78 276795 2932 79464583
Humoral immune defect 89.23 10.46 39 276834 397 79467118
Intentional self-injury 88.99 10.46 6 276867 32413 79435102
Ileal ulcer 88.91 10.46 53 276820 1077 79466438
Liver transplant failure 88.67 10.46 28 276845 99 79467416
Orthostatic hypotension 88.56 10.46 42 276831 56122 79411393
Corynebacterium infection 88.06 10.46 56 276817 1282 79466233
Cardio-respiratory arrest 87.78 10.46 151 276722 108359 79359156
Dermoid cyst 87.72 10.46 35 276838 277 79467238
Full blood count abnormal 87.65 10.46 17 276856 40457 79427058
B-cell lymphoma 87.52 10.46 108 276765 6107 79461408
Penicillium infection 87.25 10.46 34 276839 251 79467264
Orf 86.47 10.46 24 276849 46 79467469
Proteus infection 86.19 10.46 66 276807 2052 79465463
Enterococcal bacteraemia 85.97 10.46 77 276796 2991 79464524
Gastroenteritis sapovirus 85.73 10.46 29 276844 134 79467381
International normalised ratio increased 85.25 10.46 101 276772 84620 79382895
Medication error 85.10 10.46 68 276805 68574 79398941
Blood creatine phosphokinase increased 85.08 10.46 63 276810 66027 79401488
Pulmonary alveolar haemorrhage 84.94 10.46 147 276726 11310 79456205
Eczema herpeticum 84.69 10.46 34 276839 274 79467241
White blood cell count decreased 84.61 10.46 351 276522 187937 79279578
Injection site swelling 84.49 10.46 29 276844 47103 79420412
Gingival hypertrophy 84.39 10.46 77 276796 3065 79464450
Disseminated blastomycosis 84.27 10.46 30 276843 166 79467349
Drug effective for unapproved indication 84.05 10.46 104 276769 5897 79461618
Influenza like illness 84.03 10.46 75 276798 71632 79395883
Swollen tongue 83.93 10.46 22 276851 42548 79424967
Road traffic accident 83.39 10.46 24 276849 43640 79423875
Agitation 83.21 10.46 136 276737 99579 79367936
Muscular weakness 83.03 10.46 283 276590 160446 79307069
Intentional product misuse 83.02 10.46 126 276747 95039 79372476
Bone pain 82.93 10.46 45 276828 55697 79411818
Oesophageal candidiasis 82.84 10.46 129 276744 9089 79458426
Diaphragmatic hernia 82.83 10.46 36 276837 361 79467154
Toxic optic neuropathy 82.79 10.46 51 276822 1102 79466413
Atrial fibrillation 82.77 10.46 379 276494 197507 79270008
Anuria 82.18 10.46 207 276666 20756 79446759
Meningitis bacterial 81.41 10.46 71 276802 2661 79464854
Epstein Barr virus positive mucocutaneous ulcer 81.30 10.46 45 276828 790 79466725
Unevaluable event 81.07 10.46 46 276827 55539 79411976
Throat irritation 81.03 10.46 21 276852 40925 79426590
Feeling hot 80.77 10.46 54 276819 59680 79407835
Impaired healing 80.45 10.46 112 276761 87543 79379972
Neutrophil count decreased 80.43 10.46 126 276747 93833 79373682
Reversible cerebral vasoconstriction syndrome 80.32 10.46 74 276799 2983 79464532
Dysphonia 80.21 10.46 49 276824 56823 79410692
Large intestinal ulcer 80.20 10.46 91 276782 4706 79462809
Hepatic fibrosis 80.02 10.46 112 276761 7168 79460347
Leukoencephalopathy 79.83 10.46 117 276756 7812 79459703
Adverse drug reaction 79.55 10.46 68 276805 66324 79401191
Necrotising oesophagitis 79.33 10.46 49 276824 1064 79466451
Coccidioidomycosis 79.18 10.46 52 276821 1260 79466255
Cytomegalovirus syndrome 78.54 10.46 32 276841 269 79467246
Rhabdomyolysis 78.51 10.46 149 276724 102982 79364533
Fungaemia 78.30 10.46 88 276785 4503 79463012
Rash pruritic 78.01 10.46 80 276793 71549 79395966
Photodermatosis 77.90 10.46 46 276827 918 79466597
Blood potassium decreased 77.72 10.46 32 276841 46480 79421035
Body temperature decreased 77.50 10.46 10 276863 32135 79435380
Cytomegalovirus gastroenteritis 77.45 10.46 36 276837 428 79467087
Mediastinitis 77.17 10.46 44 276829 820 79466695
Abdominal distension 76.88 10.46 190 276683 119460 79348055
Superinfection bacterial 76.73 10.46 54 276819 1470 79466045
Meningitis viral 76.66 10.46 60 276813 1928 79465587
Disseminated aspergillosis 76.60 10.46 48 276825 1070 79466445
Folliculitis 76.33 10.46 49 276824 55331 79412184
Gait inability 76.05 10.46 56 276817 58861 79408654
Peritonitis 75.77 10.46 242 276631 27794 79439721
Vascular hyalinosis 75.54 10.46 24 276849 87 79467428
Graft thrombosis 75.38 10.46 35 276838 415 79467100
Osteonecrosis of jaw 75.10 10.46 28 276845 43198 79424317
Herpes simplex hepatitis 74.90 10.46 37 276836 508 79467007
Pulmonary embolism 74.65 10.46 324 276549 171330 79296185
Hyperglycaemia 74.31 10.46 458 276415 69877 79397638
Pericarditis fungal 74.16 10.46 27 276846 161 79467354
Erythema infectiosum 73.98 10.46 28 276845 189 79467326
Blood pressure decreased 73.72 10.46 146 276727 99320 79368195
Device expulsion 73.36 10.46 4 276869 25857 79441658
Oesophageal ulcer 73.25 10.46 105 276768 6870 79460645
Pleural effusion 73.12 10.46 799 276074 144463 79323052
Anaphylactic reaction 72.93 10.46 111 276762 83632 79383883
Biliary tract disorder 72.47 10.46 54 276819 1610 79465905
Perinephric collection 72.26 10.46 32 276841 337 79467178
Portal vein thrombosis 72.17 10.46 95 276778 5732 79461783
Brain herniation 72.09 10.46 108 276765 7355 79460160
Transplantation complication 71.67 10.46 31 276842 307 79467208
Chronic hepatitis C 71.39 10.46 38 276835 615 79466900
Graft infection 71.11 10.46 39 276834 672 79466843
Brain oedema 70.97 10.46 221 276652 25042 79442473
Injection site pruritus 70.80 10.46 29 276844 42254 79425261
Urinary tract infection viral 70.64 10.46 21 276852 57 79467458
Disseminated cytomegaloviral infection 70.54 10.46 34 276839 441 79467074
Chromoblastomycosis 70.51 10.46 22 276851 74 79467441
Joint injury 70.36 10.46 12 276861 31323 79436192
Heart rate irregular 70.19 10.46 14 276859 32665 79434850
Tuberculosis gastrointestinal 70.18 10.46 36 276837 538 79466977
Renal tubular disorder 70.12 10.46 99 276774 6387 79461128
Oesophageal stenosis 70.09 10.46 81 276792 4273 79463242
Graft versus host disease in eye 70.08 10.46 30 276843 289 79467226
Joint stiffness 70.01 10.46 27 276846 40803 79426712
Labelled drug-drug interaction medication error 69.63 10.46 233 276640 27417 79440098
Haemodynamic instability 69.56 10.46 173 276700 17209 79450306
Transient ischaemic attack 69.44 10.46 49 276824 52646 79414869
Cerebral fungal infection 69.43 10.46 33 276840 414 79467101
Swelling face 69.43 10.46 87 276786 71125 79396390
Chills 69.34 10.46 303 276570 159931 79307584
SARS-CoV-2 RNA increased 69.11 10.46 23 276850 100 79467415
Anti-erythropoietin antibody negative 69.01 10.46 30 276843 301 79467214
Serum sickness 68.99 10.46 74 276799 3592 79463923
Clostridial infection 68.99 10.46 92 276781 5622 79461893
Urinoma 68.98 10.46 27 276846 202 79467313
Device issue 68.94 10.46 7 276866 27101 79440414
Hepatic artery stenosis 68.89 10.46 26 276847 174 79467341
Perinephric abscess 68.76 10.46 28 276845 235 79467280
Norovirus infection 68.71 10.46 38 276835 666 79466849
Sleep disorder 68.59 10.46 120 276753 85557 79381958
Ureteral necrosis 68.57 10.46 22 276851 83 79467432
Hepatitis B 68.55 10.46 112 276761 8220 79459295
Central nervous system fungal infection 68.53 10.46 33 276840 427 79467088
Shock haemorrhagic 68.35 10.46 188 276685 19872 79447643
Bronchiolitis obliterans syndrome 68.33 10.46 30 276843 309 79467206
Pyelonephritis fungal 67.86 10.46 27 276846 212 79467303
Type 2 diabetes mellitus 67.83 10.46 59 276814 57063 79410452
Pulmonary tuberculosis 67.82 10.46 108 276765 7757 79459758
Mycobacterium chelonae infection 67.56 10.46 61 276812 2395 79465120
Cutaneous nocardiosis 67.18 10.46 26 276847 188 79467327
Sopor 67.13 10.46 16 276857 32994 79434521
Heartland virus infection 66.64 10.46 17 276856 19 79467496
Loss of personal independence in daily activities 66.61 10.46 162 276711 102418 79365097
Capillaritis 66.40 10.46 28 276845 259 79467256
Dysplastic naevus 66.11 10.46 35 276838 560 79466955
Abdominal infection 66.10 10.46 72 276801 3557 79463958
Gastroenteritis cryptosporidial 65.93 10.46 28 276845 264 79467251
Trichosporon infection 65.87 10.46 42 276831 966 79466549
Dehydration 65.84 10.46 548 276325 247639 79219876
Obesity 65.82 10.46 20 276853 35105 79432410
Histology abnormal 65.60 10.46 29 276844 304 79467211
Thrombotic thrombocytopenic purpura 65.52 10.46 95 276778 6281 79461234
Pancreatitis haemorrhagic 65.49 10.46 39 276834 791 79466724
Bone marrow failure 65.25 10.46 350 276523 50757 79416758
Angioedema 65.04 10.46 102 276771 75933 79391582
Aggression 65.04 10.46 49 276824 50909 79416606
Disseminated toxoplasmosis 64.92 10.46 26 276847 208 79467307
Microangiopathy 64.90 10.46 53 276820 1812 79465703
Choriomeningitis lymphocytic 64.89 10.46 19 276854 48 79467467
Histoplasmosis cutaneous 64.89 10.46 19 276854 48 79467467
Urinary fistula 64.62 10.46 20 276853 65 79467450
Wound dehiscence 64.51 10.46 96 276777 6499 79461016
Vision blurred 64.32 10.46 173 276700 105725 79361790
Post procedural urine leak 64.05 10.46 23 276850 131 79467384
Staphylococcal sepsis 63.67 10.46 151 276722 14575 79452940
Burkholderia cepacia complex infection 63.63 10.46 28 276845 290 79467225
Cognitive disorder 63.51 10.46 90 276783 69836 79397679
Idiopathic pneumonia syndrome 63.24 10.46 34 276839 562 79466953
Babesiosis 63.20 10.46 29 276844 334 79467181
Chronic graft versus host disease in intestine 63.05 10.46 29 276844 336 79467179
Poor quality sleep 62.97 10.46 4 276869 22718 79444797
Candida sepsis 62.50 10.46 59 276814 2454 79465061
Cardiac disorder 62.38 10.46 82 276791 65675 79401840
Feeling cold 62.35 10.46 12 276861 28717 79438798
Fluid retention 62.27 10.46 91 276782 69718 79397797
Transitional cell carcinoma 61.94 10.46 59 276814 2482 79465033
Prescribed overdose 61.80 10.46 27 276846 37856 79429659
Metastatic squamous cell carcinoma 61.73 10.46 33 276840 539 79466976
Enteritis 61.40 10.46 148 276725 14435 79453080
Optic atrophy 61.18 10.46 52 276821 1881 79465634
Malacoplakia vesicae 61.10 10.46 19 276854 63 79467452
Endocarditis 61.05 10.46 122 276751 10475 79457040
Limb discomfort 61.02 10.46 19 276854 32831 79434684
Granuloma 60.92 10.46 106 276767 8191 79459324
Microangiopathic haemolytic anaemia 60.86 10.46 47 276826 1480 79466035
MELAS syndrome 60.81 10.46 24 276849 184 79467331
Hepatocellular carcinoma 60.77 10.46 111 276762 8910 79458605
Glomerulonephritis membranous 60.65 10.46 48 276825 1568 79465947
Device dislocation 60.44 10.46 9 276864 25961 79441554
Dysplasia 60.41 10.46 45 276828 1341 79466174
Red blood cell sedimentation rate abnormal 60.23 10.46 3 276870 20960 79446555
Citrobacter infection 59.89 10.46 39 276834 931 79466584
Fungal sepsis 59.51 10.46 50 276823 1780 79465735
Lip swelling 59.45 10.46 34 276839 40877 79426638
Intracranial pressure increased 59.39 10.46 105 276768 8217 79459298
Bursitis 59.34 10.46 25 276848 35819 79431696
Foot deformity 59.24 10.46 7 276866 24067 79443448
Muir-Torre syndrome 59.20 10.46 17 276856 39 79467476
Hyperglycaemic hyperosmolar nonketotic syndrome 59.06 10.46 55 276818 2248 79465267
Lung consolidation 58.90 10.46 109 276764 8838 79458677
Cutaneous T-cell lymphoma 58.86 10.46 59 276814 2644 79464871
Blood pressure diastolic decreased 58.84 10.46 16 276857 30200 79437315
Tinnitus 58.71 10.46 41 276832 44292 79423223
Respiratory distress 58.58 10.46 375 276498 57964 79409551
Plasmablastic lymphoma 58.56 10.46 31 276842 496 79467019
Dyspnoea exertional 58.53 10.46 135 276738 86938 79380577
Hallucination 58.40 10.46 132 276741 85613 79381902
Complications of bone marrow transplant 57.97 10.46 33 276840 613 79466902
Vertigo 57.84 10.46 94 276779 68988 79398527
Cutaneous blastomycosis 57.53 10.46 16 276857 31 79467484
Respiratory arrest 57.48 10.46 69 276804 57481 79410034
Grip strength decreased 57.34 10.46 5 276868 21864 79445651
Meningoencephalitis viral 57.34 10.46 29 276844 420 79467095
Sebaceous carcinoma 57.20 10.46 20 276853 104 79467411
Rhinorrhoea 56.95 10.46 111 276762 75963 79391552
Central nervous system viral infection 56.89 10.46 20 276853 106 79467409
Solar lentigo 56.71 10.46 40 276833 1093 79466422
Hepatic necrosis 56.35 10.46 108 276765 8992 79458523
Inflammatory bowel disease 56.34 10.46 83 276790 5568 79461947
Drug dependence 56.28 10.46 36 276837 40733 79426782
Renal vein thrombosis 56.22 10.46 31 276842 540 79466975
Musculoskeletal disorder 55.97 10.46 5 276868 21443 79446072
Exposure during pregnancy 55.92 10.46 567 276306 100565 79366950
Arteritis infective 55.88 10.46 18 276855 69 79467446
Lymphocytic infiltration 55.87 10.46 45 276828 1508 79466007
Gastroenteritis adenovirus 55.76 10.46 27 276846 354 79467161
Burning sensation 55.74 10.46 73 276800 58559 79408956
Presyncope 55.66 10.46 37 276836 41017 79426498
Glomerulonephritis rapidly progressive 55.61 10.46 46 276827 1602 79465913
Herpes zoster meningoencephalitis 55.51 10.46 34 276839 727 79466788
Anaphylactic shock 55.11 10.46 28 276845 35968 79431547
Underdose 55.08 10.46 23 276850 33128 79434387
Portal hypertension 55.07 10.46 93 276780 7015 79460500
Primary effusion lymphoma 55.04 10.46 16 276857 39 79467476
Splenic abscess 54.98 10.46 31 276842 565 79466950
Subcapsular renal haematoma 54.85 10.46 34 276839 743 79466772
Neoplasm progression 54.84 10.46 59 276814 51623 79415892
Cholestasis 54.84 10.46 339 276534 51770 79415745
Enterococcal sepsis 54.81 10.46 57 276816 2669 79464846
Drug ineffective 54.73 10.46 4407 272466 1076506 78391009
Drug withdrawal syndrome 54.68 10.46 26 276847 34692 79432823
Hepatosplenomegaly 54.63 10.46 85 276788 5984 79461531
Acute myocardial infarction 54.60 10.46 116 276757 76920 79390595
Necrosis 54.34 10.46 109 276764 9384 79458131
Emotional distress 54.22 10.46 36 276837 39933 79427582
Bone marrow transplant rejection 54.01 10.46 24 276849 255 79467260
Haematemesis 53.99 10.46 61 276812 52203 79415312
Respiratory syncytial virus infection 53.87 10.46 108 276765 9294 79458221
Legionella infection 53.55 10.46 34 276839 776 79466739
Muscle abscess 53.50 10.46 38 276835 1050 79466465
Hepatosplenic T-cell lymphoma 53.48 10.46 35 276838 843 79466672
Flatulence 53.36 10.46 42 276831 42682 79424833
Renal abscess 53.35 10.46 38 276835 1055 79466460
Drug level below therapeutic 53.34 10.46 110 276763 9660 79457855
Necrotising retinitis 53.33 10.46 40 276833 1205 79466310
Arterial rupture 53.32 10.46 34 276839 782 79466733
Parainfluenzae virus infection 53.14 10.46 81 276792 5601 79461914
Diffuse alveolar damage 52.97 10.46 64 276809 3540 79463975
Head injury 52.97 10.46 32 276841 37337 79430178
Chimerism 52.65 10.46 24 276849 272 79467243
Amnesia 52.61 10.46 86 276787 62971 79404544
Engraft failure 52.37 10.46 32 276841 681 79466834
Thyroid gland abscess 52.01 10.46 17 276856 69 79467446
Injection site haemorrhage 51.98 10.46 16 276857 27854 79439661
Depressed mood 51.83 10.46 55 276818 48425 79419090
Hip fracture 51.66 10.46 21 276852 30740 79436775
Accidental exposure to product 51.61 10.46 22 276851 31300 79436215
Mycobacterium haemophilum infection 51.54 10.46 19 276854 118 79467397
Klebsiella sepsis 51.52 10.46 60 276813 3192 79464323
Varicella 51.37 10.46 57 276816 2875 79464640
Pneumopericardium 51.29 10.46 21 276852 179 79467336
Rhinovirus infection 51.24 10.46 96 276777 7857 79459658
Haematochezia 51.12 10.46 146 276727 87499 79380016
Cryptococcal cutaneous infection 51.09 10.46 21 276852 181 79467334
Atypical mycobacterial pneumonia 51.05 10.46 20 276853 150 79467365
Skin squamous cell carcinoma metastatic 51.01 10.46 16 276857 55 79467460
Alopecia 50.96 10.46 535 276338 230820 79236695
Drug level changed 50.60 10.46 29 276844 546 79466969
Reticulocytopenia 50.41 10.46 22 276851 223 79467292
Hepatitis cholestatic 50.39 10.46 133 276740 13719 79453796
Skin mass 50.31 10.46 96 276777 7967 79459548
Electrocardiogram QT prolonged 50.24 10.46 154 276719 90232 79377283
Pneumonia influenzal 50.10 10.46 56 276817 2848 79464667
Pallor 50.02 10.46 60 276813 50002 79417513
Encephalitis autoimmune 49.82 10.46 50 276823 2244 79465271
Dehiscence 49.62 10.46 20 276853 163 79467352
Ventricular remodelling 49.49 10.46 18 276855 107 79467408
Adult T-cell lymphoma/leukaemia 49.47 10.46 24 276849 316 79467199
Evans syndrome 49.17 10.46 26 276847 415 79467100
Tooth disorder 49.04 10.46 15 276858 26218 79441297
Chronic graft versus host disease oral 49.02 10.46 19 276854 138 79467377
Biloma 49.02 10.46 19 276854 138 79467377
Hypothyroidism 49.02 10.46 66 276807 52326 79415189
Infectious thyroiditis 48.93 10.46 18 276855 111 79467404
Rheumatoid nodule 48.54 10.46 3 276870 17435 79450080
Speech disorder 48.53 10.46 71 276802 54374 79413141
Upper respiratory fungal infection 48.49 10.46 24 276849 331 79467184
Lethargy 48.46 10.46 134 276739 81158 79386357
Skin laceration 48.27 10.46 20 276853 28942 79438573
Irritability 48.24 10.46 43 276830 41101 79426414
Aspergilloma 48.23 10.46 29 276844 599 79466916
Abscess fungal 48.17 10.46 24 276849 336 79467179
Dysstasia 48.15 10.46 18 276855 27728 79439787
Neutralising antibodies negative 47.93 10.46 11 276862 4 79467511
Vascular pseudoaneurysm 47.83 10.46 60 276813 3450 79464065
Respiratory depression 47.82 10.46 18 276855 27612 79439903
Impaired work ability 47.74 10.46 6 276867 19675 79447840
Coronary artery disease 47.74 10.46 97 276776 65377 79402138
Urinary tract infection enterococcal 47.60 10.46 58 276815 3237 79464278
Subcutaneous abscess 47.59 10.46 93 276780 7856 79459659
Disability 47.49 10.46 3 276870 17117 79450398
Tularaemia 47.46 10.46 17 276856 96 79467419
Fungal abscess central nervous system 47.37 10.46 18 276855 123 79467392
Full blood count decreased 47.22 10.46 17 276856 26802 79440713
Crying 47.19 10.46 11 276862 23032 79444483
Scrotal ulcer 46.95 10.46 25 276848 405 79467110
Septic embolus 46.94 10.46 46 276827 2005 79465510
Postoperative wound infection 46.70 10.46 124 276749 12837 79454678
Normocytic anaemia 46.65 10.46 65 276808 4142 79463373
Skin squamous cell carcinoma recurrent 46.57 10.46 14 276859 40 79467475
Hyponatraemia 46.55 10.46 394 276479 177454 79290061
Muscle spasticity 46.54 10.46 9 276864 21466 79446049
Granulomatous rosacea 46.42 10.46 20 276853 196 79467319
Corneal endotheliitis 46.27 10.46 16 276857 80 79467435
Sporotrichosis 46.19 10.46 17 276856 105 79467410
Urosepsis 45.79 10.46 198 276675 26297 79441218
Paraesthesia oral 45.61 10.46 8 276865 20463 79447052
Hypertrophic osteoarthropathy 45.40 10.46 17 276856 111 79467404
Disseminated trichosporonosis 45.38 10.46 18 276855 140 79467375
Anastomotic stenosis 44.88 10.46 26 276847 500 79467015
Toxic encephalopathy 44.88 10.46 113 276760 11327 79456188
Serratia infection 44.75 10.46 42 276831 1734 79465781
Injection site mass 44.72 10.46 8 276865 20176 79447339
Systemic bacterial infection 44.67 10.46 14 276859 48 79467467
Abdominal pain 44.64 10.46 1021 275852 388548 79078967
Cold sweat 44.64 10.46 6 276867 18693 79448822
Disturbance in attention 44.55 10.46 67 276806 50734 79416781
Nightmare 44.51 10.46 17 276856 25844 79441671
Pulmonary haemorrhage 44.39 10.46 132 276741 14585 79452930
Localised infection 44.38 10.46 39 276834 37536 79429979
Pancreatitis necrotising 44.26 10.46 61 276812 3847 79463668
Pleocytosis 44.10 10.46 38 276835 1401 79466114
Splenomegaly 43.77 10.46 165 276708 20589 79446926
Frequent bowel movements 43.71 10.46 24 276849 29515 79438000
Meningomyelitis herpes 43.71 10.46 15 276858 73 79467442
Vesicoureteric reflux 43.68 10.46 17 276856 125 79467390
Body temperature increased 43.58 10.46 54 276819 44366 79423149
Hepatitis B reactivation 43.50 10.46 77 276796 6031 79461484
Platelet count decreased 43.33 10.46 449 276424 194215 79273300
Respiratory tract infection fungal 43.33 10.46 35 276838 1178 79466337
Ecthyma 43.29 10.46 29 276844 727 79466788
Peritonitis pneumococcal 43.23 10.46 12 276861 23 79467492
Escherichia sepsis 43.21 10.46 93 276780 8415 79459100
Hepatitis viral 43.12 10.46 33 276840 1025 79466490
Metastases to lung 43.05 10.46 150 276723 18013 79449502
Serotonin syndrome 42.86 10.46 56 276817 44971 79422544
Mycobacterium fortuitum infection 42.83 10.46 19 276854 201 79467314
Nervousness 42.81 10.46 32 276841 33383 79434132
Disease progression 42.79 10.46 421 276452 183941 79283574
Psoriasis 42.76 10.46 163 276710 89424 79378091
Lymphadenitis bacterial 42.74 10.46 15 276858 79 79467436
Lactic acidosis 42.68 10.46 115 276758 70244 79397271
Haemolysis 42.59 10.46 119 276754 12693 79454822
Leiomyosarcoma 42.58 10.46 22 276851 334 79467181
Pericarditis constrictive 42.58 10.46 27 276846 615 79466900
Rib fracture 42.39 10.46 22 276851 27925 79439590
Stevens-Johnson syndrome 42.35 10.46 44 276829 39122 79428393
Chronic graft versus host disease in eye 42.34 10.46 17 276856 137 79467378
Intestinal tuberculosis 42.34 10.46 19 276854 207 79467308
Prostatitis 42.30 10.46 62 276811 4140 79463375
Disseminated varicella zoster vaccine virus infection 42.28 10.46 16 276857 108 79467407
Bone marrow transplant 41.88 10.46 37 276836 1411 79466104
Angina pectoris 41.82 10.46 72 276801 51660 79415855
Encephalomyelitis 41.78 10.46 19 276854 214 79467301
Sinus congestion 41.74 10.46 9 276864 19887 79447628
Sinus disorder 41.71 10.46 13 276860 22451 79445064
Alpha haemolytic streptococcal infection 41.56 10.46 46 276827 2314 79465201
Abdominal wall abscess 41.47 10.46 34 276839 1169 79466346
Gastritis fungal 41.46 10.46 18 276855 180 79467335
Renal necrosis 41.32 10.46 20 276853 262 79467253
Diarrhoea haemorrhagic 41.16 10.46 120 276753 13114 79454401
T-cell lymphoma 41.13 10.46 35 276838 1268 79466247
Eye infection toxoplasmal 41.13 10.46 25 276848 527 79466988
Immunosuppressant drug level 41.11 10.46 11 276862 17 79467498
Sciatica 41.06 10.46 33 276840 33189 79434326
Neuroendocrine carcinoma of the skin 40.92 10.46 35 276838 1277 79466238
Malignant fibrous histiocytoma 40.69 10.46 18 276855 189 79467326
Delayed engraftment 40.66 10.46 20 276853 272 79467243
Sarcoma of skin 40.65 10.46 14 276859 69 79467446
Pleural mesothelioma malignant 40.24 10.46 17 276856 158 79467357
Human herpesvirus 6 infection reactivation 40.19 10.46 25 276848 550 79466965
Anorexia nervosa 40.07 10.46 19 276854 237 79467278
Femur fracture 40.04 10.46 45 276828 38607 79428908
Emphysematous cystitis 39.78 10.46 21 276852 334 79467181
C3 glomerulopathy 39.73 10.46 13 276860 53 79467462
Skin lesion 39.59 10.46 265 276608 41579 79425936
Nosocomial infection 39.54 10.46 49 276824 2783 79464732
Limb injury 39.51 10.46 27 276846 29501 79438014
Soft tissue mass 39.44 10.46 34 276839 1254 79466261
Herpes zoster cutaneous disseminated 39.44 10.46 23 276850 448 79467067
Multiple sclerosis 39.44 10.46 14 276859 22268 79445247
Cholelithiasis 39.28 10.46 77 276796 52587 79414928
Disseminated coccidioidomycosis 39.12 10.46 16 276857 136 79467379
Granulomatous dermatitis 39.11 10.46 22 276851 399 79467116
Isosporiasis 39.07 10.46 17 276856 171 79467344
Cholangitis sclerosing 39.04 10.46 47 276826 2590 79464925
Glomerulonephropathy 38.98 10.46 20 276853 299 79467216
Device malfunction 38.78 10.46 13 276860 21435 79446080
Aortic pseudoaneurysm 38.77 10.46 12 276861 39 79467476
Carpal tunnel syndrome 38.67 10.46 10 276863 19518 79447997
Laryngitis 38.64 10.46 5 276868 16034 79451481
Purtscher retinopathy 38.46 10.46 15 276858 111 79467404
Eye swelling 38.45 10.46 22 276851 26446 79441069
Coma 38.45 10.46 199 276674 100450 79367065
Hypersomnia 38.38 10.46 16 276857 23070 79444445
Panic attack 38.34 10.46 18 276855 24198 79443317
Parvovirus infection 38.29 10.46 26 276847 667 79466848
Restlessness 38.23 10.46 64 276809 46428 79421087
Meningitis fungal 38.22 10.46 17 276856 181 79467334
Night sweats 38.14 10.46 77 276796 52018 79415497
Gastrointestinal mucormycosis 38.12 10.46 22 276851 420 79467095
Respiratory tract congestion 38.04 10.46 11 276862 19943 79447572
Ear infection 38.01 10.46 38 276835 34394 79433121
Incision site pain 37.97 10.46 48 276825 2782 79464733
Sputum discoloured 37.91 10.46 14 276859 21729 79445786
C-reactive protein increased 37.87 10.46 277 276596 128750 79338765
Upper gastrointestinal haemorrhage 37.83 10.46 53 276820 41327 79426188
Stem cell transplant 37.79 10.46 55 276818 3649 79463866
Vascular graft complication 37.76 10.46 16 276857 150 79467365
Anger 37.60 10.46 7 276866 17155 79450360
Rotator cuff syndrome 37.57 10.46 3 276870 14092 79453423
Inferior vena cava stenosis 37.46 10.46 12 276861 45 79467470
Oesophageal perforation 37.39 10.46 36 276837 1535 79465980
Scleroderma 37.37 10.46 68 276805 5442 79462073
Oesophageal achalasia 37.37 10.46 27 276846 767 79466748
Intraductal papillary mucinous neoplasm 37.24 10.46 27 276846 771 79466744
Palmar-plantar erythrodysaesthesia syndrome 37.23 10.46 36 276837 33098 79434417
Limbic encephalitis 37.23 10.46 28 276845 847 79466668
Gastroenteritis Escherichia coli 37.21 10.46 25 276848 630 79466885
Injection site warmth 37.20 10.46 4 276869 14803 79452712
Blood test abnormal 37.18 10.46 8 276865 17702 79449813
Hepatitis C virus test 37.12 10.46 13 276860 68 79467447
Morganella infection 37.08 10.46 31 276842 1096 79466419
Mycobacterium marinum infection 36.91 10.46 22 276851 447 79467068
Splenic vein thrombosis 36.88 10.46 27 276846 783 79466732
Dengue fever 36.78 10.46 28 276845 863 79466652
Tachycardia 36.77 10.46 417 276456 177351 79290164
Throat tightness 36.70 10.46 26 276847 27881 79439634
Lip dry 36.68 10.46 5 276868 15413 79452102
Hepatitis C RNA increased 36.66 10.46 21 276852 395 79467120
Photosensitivity reaction 36.60 10.46 158 276715 20969 79446546
Pericardial effusion 36.32 10.46 280 276593 45957 79421558
Influenza 36.26 10.46 282 276591 129324 79338191
Acute hepatitis C 36.14 10.46 17 276856 208 79467307
Mood swings 36.04 10.46 12 276861 19868 79447647
Large intestine perforation 36.01 10.46 122 276751 14445 79453070
Hypoacusis 35.97 10.46 31 276842 30119 79437396
Renal cyst haemorrhage 35.96 10.46 25 276848 667 79466848
Dysphagia 35.95 10.46 262 276611 121874 79345641
Biopsy kidney abnormal 35.92 10.46 16 276857 171 79467344
Renal disorder 35.92 10.46 260 276613 41845 79425670
Dialysis 35.85 10.46 143 276730 18319 79449196
Overdose 35.83 10.46 438 276435 183768 79283747
Bacteriuria 35.81 10.46 32 276841 1239 79466276
Hepatic cancer recurrent 35.69 10.46 18 276855 259 79467256
Cutaneous tuberculosis 35.58 10.46 17 276856 216 79467299
Aspergillus test positive 35.58 10.46 26 276847 752 79466763
Left ventricular hypertrophy 35.31 10.46 102 276771 11089 79456426
Adenovirus reactivation 35.26 10.46 20 276853 369 79467146
Herpes zoster reactivation 35.20 10.46 16 276857 180 79467335
Endocarditis enterococcal 35.18 10.46 15 276858 143 79467372
Cytomegalovirus urinary tract infection 35.09 10.46 13 276860 82 79467433
Arrhythmia 35.05 10.46 103 276770 61169 79406346
Basal cell carcinoma 34.94 10.46 236 276637 37139 79430376
Clostridium difficile infection 34.94 10.46 261 276612 42424 79425091
Gastrointestinal toxicity 34.89 10.46 83 276790 8026 79459489
Pharyngeal polyp 34.85 10.46 9 276864 11 79467504
Apoptosis 34.81 10.46 22 276851 498 79467017
Dyslipidaemia 34.76 10.46 104 276769 11529 79455986
Paranoia 34.75 10.46 12 276861 19420 79448095
Gastrointestinal fungal infection 34.73 10.46 22 276851 500 79467015
Hepatic vein stenosis 34.71 10.46 12 276861 60 79467455
Faeces discoloured 34.68 10.46 30 276843 29097 79438418
Toxic skin eruption 34.64 10.46 17 276856 22276 79445239
Renal and pancreas transplant rejection 34.60 10.46 11 276862 40 79467475
Skin graft rejection 34.51 10.46 10 276863 24 79467491
Renal haematoma 34.50 10.46 26 276847 789 79466726
Gallbladder disorder 34.49 10.46 12 276861 19328 79448187
Potentiating drug interaction 34.48 10.46 87 276786 8732 79458783
Hiatus hernia 34.41 10.46 19 276854 23293 79444222
Tendonitis 34.35 10.46 20 276853 23810 79443705
Chemical peritonitis 34.28 10.46 18 276855 283 79467232
Breast cancer 34.27 10.46 40 276833 33741 79433774
Troponin increased 34.25 10.46 12 276861 19243 79448272
H1N1 influenza 34.23 10.46 43 276830 2476 79465039
Needle issue 34.23 10.46 3 276870 13065 79454450
Joint range of motion decreased 34.21 10.46 39 276834 33243 79434272
Lupus nephritis 34.14 10.46 47 276826 2961 79464554
Aspartate aminotransferase increased 34.13 10.46 312 276561 138329 79329186
Angiocentric lymphoma 34.11 10.46 27 276846 882 79466633
Tonsil cancer 34.09 10.46 30 276843 1138 79466377
Injection site rash 34.04 10.46 10 276863 17944 79449571
Breath sounds abnormal 34.01 10.46 7 276866 15977 79451538
Cryoglobulinaemia 33.99 10.46 26 276847 807 79466708
Central nervous system lesion 33.97 10.46 113 276760 13255 79454260
Tuberculosis 33.87 10.46 123 276750 15075 79452440
Bone disorder 33.84 10.46 12 276861 19101 79448414
Blood pressure systolic abnormal 33.83 10.46 9 276864 17238 79450277
Intervertebral disc protrusion 33.80 10.46 20 276853 23601 79443914
Gestational hypertension 33.74 10.46 37 276836 1842 79465673
Status epilepticus 33.68 10.46 174 276699 24867 79442648
Transplant abscess 33.68 10.46 10 276863 27 79467488
Ureteric anastomosis complication 33.68 10.46 10 276863 27 79467488
Oedematous kidney 33.65 10.46 16 276857 201 79467314
Nephritis haemorrhagic 33.60 10.46 9 276864 14 79467501
Metabolic acidosis 33.60 10.46 436 276437 82093 79385422
Protothecosis 33.59 10.46 11 276862 45 79467470
Infective pulmonary exacerbation of cystic fibrosis 33.52 10.46 3 276870 12848 79454667
Herpes virus infection 33.47 10.46 75 276798 6974 79460541
Hepatic angiosarcoma 33.41 10.46 10 276863 28 79467487
Diabetic cardiomyopathy 33.41 10.46 10 276863 28 79467487
Pneumonia herpes viral 33.30 10.46 15 276858 165 79467350
Pseudomonal bacteraemia 33.26 10.46 47 276826 3035 79464480
Urate nephropathy 33.14 10.46 15 276858 167 79467348
Therapy interrupted 33.01 10.46 36 276837 31305 79436210
Cataract 33.00 10.46 108 276765 62012 79405503
Toothache 32.94 10.46 14 276859 19956 79447559
Pollakiuria 32.93 10.46 49 276824 37268 79430247
Lymphoma 32.92 10.46 134 276739 17326 79450189
Metastatic malignant melanoma 32.90 10.46 45 276828 2818 79464697
Hepatic vein occlusion 32.83 10.46 16 276857 213 79467302
Infusion site pain 32.79 10.46 5 276868 14171 79453344
Withdrawal syndrome 32.78 10.46 27 276846 26827 79440688
Epstein-Barr virus antibody positive 32.75 10.46 23 276850 624 79466891
Renal arteriosclerosis 32.62 10.46 18 276855 314 79467201
Oedema 32.61 10.46 262 276611 119318 79348197
Chromaturia 32.54 10.46 25 276848 25721 79441794
Gallbladder rupture 32.28 10.46 27 276846 955 79466560
Akathisia 32.27 10.46 4 276869 13255 79454260
Blood glucose increased 32.24 10.46 250 276623 114725 79352790
Lacrimation increased 32.20 10.46 19 276854 22458 79445057
Bile duct necrosis 32.17 10.46 9 276864 18 79467497
Tongue disorder 32.16 10.46 5 276868 13970 79453545
Lung abscess 32.12 10.46 54 276819 4058 79463457
Drug eruption 32.11 10.46 65 276808 43870 79423645
Dyskinesia 32.08 10.46 67 276806 44706 79422809
Intussusception 32.07 10.46 29 276844 1141 79466374
Nodular regenerative hyperplasia 32.04 10.46 31 276842 1330 79466185
Acute generalised exanthematous pustulosis 32.01 10.46 10 276863 17244 79450271
Obstructive nephropathy 31.98 10.46 11 276862 54 79467461
Bone erosion 31.95 10.46 11 276862 17836 79449679
Viral vasculitis 31.90 10.46 14 276859 144 79467371
Ejection fraction decreased 31.90 10.46 44 276829 34533 79432982
Cell death 31.88 10.46 58 276815 4641 79462874
Pancreas transplant 31.81 10.46 11 276862 55 79467460
Nephrectomy 31.81 10.46 38 276835 2077 79465438
Kidney rupture 31.80 10.46 16 276857 229 79467286
Glomerulonephritis proliferative 31.75 10.46 19 276854 389 79467126
Angina unstable 31.71 10.46 9 276864 16518 79450997
Neurological symptom 31.61 10.46 84 276789 8699 79458816
Pneumonia staphylococcal 31.61 10.46 59 276814 4815 79462700
Malignant ascites 31.60 10.46 29 276844 1163 79466352
Erythropoiesis abnormal 31.60 10.46 20 276853 454 79467061
IIIrd nerve paralysis 31.58 10.46 29 276844 1164 79466351
Surgical procedure repeated 31.51 10.46 24 276849 740 79466775
Hypoalbuminaemia 31.48 10.46 152 276721 21145 79446370
Peripheral T-cell lymphoma unspecified 31.42 10.46 23 276850 667 79466848
Viral test positive 31.40 10.46 19 276854 397 79467118
Tooth infection 31.39 10.46 13 276860 18819 79448696
Zoonotic bacterial infection 31.34 10.46 11 276862 58 79467457
Nephrocalcinosis 31.27 10.46 32 276841 1470 79466045
Cytopenia 31.24 10.46 147 276726 20236 79447279
Joint dislocation 31.10 10.46 10 276863 16929 79450586
Dementia 31.10 10.46 24 276849 24635 79442880
Abortion spontaneous 31.07 10.46 192 276681 29315 79438200
Diffuse mesangial sclerosis 31.03 10.46 11 276862 60 79467455
Molluscum contagiosum 31.03 10.46 20 276853 469 79467046
Sleep disorder due to a general medical condition 30.90 10.46 6 276867 14271 79453244
Neuroleptic malignant syndrome 30.90 10.46 30 276843 27529 79439986
Blood calcium decreased 30.88 10.46 39 276834 31780 79435735
Toxic epidermal necrolysis 30.87 10.46 68 276805 44513 79423002
Porokeratosis 30.79 10.46 16 276857 246 79467269
Salivary hypersecretion 30.74 10.46 6 276867 14218 79453297
Cutaneous leishmaniasis 30.74 10.46 17 276856 298 79467217
Microsporum infection 30.71 10.46 10 276863 40 79467475
Blood creatine increased 30.63 10.46 87 276786 9368 79458147
Urine output decreased 30.63 10.46 134 276739 17888 79449627
Blood beta-D-glucan increased 30.61 10.46 21 276852 548 79466967
Myopathy 30.57 10.46 147 276726 20416 79447099
Red blood cell count decreased 30.55 10.46 100 276773 57413 79410102
Transitional cell carcinoma metastatic 30.52 10.46 10 276863 41 79467474
Hepatic function abnormal 30.51 10.46 388 276485 72719 79394796
Herpes simplex oesophagitis 30.49 10.46 18 276855 359 79467156
Acid fast bacilli infection 30.45 10.46 14 276859 162 79467353
Viral load increased 30.40 10.46 44 276829 2904 79464611
Oesophageal squamous cell carcinoma 30.40 10.46 20 276853 486 79467029
Gastric disorder 30.34 10.46 52 276821 37381 79430134
Immune-mediated adverse reaction 30.26 10.46 25 276848 869 79466646
Product complaint 30.22 10.46 5 276868 13344 79454171
Muscle twitching 30.11 10.46 25 276848 24739 79442776
Calciphylaxis 30.10 10.46 50 276823 3720 79463795
Blood glucose decreased 30.06 10.46 28 276845 26206 79441309
Prostate cancer 30.03 10.46 43 276830 33225 79434290
Alanine aminotransferase increased 29.95 10.46 391 276482 162179 79305336
Nephritis 29.85 10.46 53 276820 4161 79463354
Enterocolitis viral 29.80 10.46 18 276855 375 79467140
Acanthoma 29.77 10.46 10 276863 45 79467470
Chronic papillomatous dermatitis 29.75 10.46 11 276862 69 79467446
Extranodal marginal zone B-cell lymphoma (MALT type) 29.73 10.46 21 276852 575 79466940
Haemosiderosis 29.66 10.46 20 276853 507 79467008
Cardiac valve vegetation 29.66 10.46 25 276848 894 79466621
Meningoencephalitis amoebic 29.60 10.46 13 276860 134 79467381
Aplastic anaemia 29.57 10.46 132 276741 17773 79449742
Miosis 29.56 10.46 9 276864 15780 79451735
Acanthamoeba keratitis 29.52 10.46 7 276866 4 79467511
Burkholderia cepacia complex sepsis 29.52 10.46 7 276866 4 79467511
Urinary incontinence 29.49 10.46 61 276812 40848 79426667
Enterocolitis 29.47 10.46 114 276759 14398 79453117
Abdominal wall infection 29.44 10.46 12 276861 101 79467414
Eye abscess 29.43 10.46 17 276856 325 79467190
Phospholipidosis 29.43 10.46 15 276858 221 79467294
Encephalitis protozoal 29.37 10.46 9 276864 28 79467487
Pulmonary air leakage 29.37 10.46 15 276858 222 79467293
Hypertensive emergency 29.36 10.46 42 276831 2743 79464772
Hyperparathyroidism secondary 29.35 10.46 41 276832 2619 79464896
Endothelial dysfunction 29.25 10.46 15 276858 224 79467291
Gastric haemorrhage 29.24 10.46 8 276865 15042 79452473
Oxalosis 29.24 10.46 12 276861 103 79467412
Febrile bone marrow aplasia 29.20 10.46 5 276868 13015 79454500
Depressed level of consciousness 29.08 10.46 206 276667 96446 79371069
Urinary retention 29.03 10.46 100 276773 56530 79410985
Pelvic deformity 28.97 10.46 11 276862 75 79467440
Unresponsive to stimuli 28.94 10.46 98 276775 55690 79411825
Multimorbidity 28.77 10.46 30 276843 1409 79466106
Cerebral microhaemorrhage 28.73 10.46 15 276858 233 79467282
Metastatic carcinoma of the bladder 28.73 10.46 15 276858 233 79467282
Milk allergy 28.65 10.46 12 276861 109 79467406
Azotaemia 28.63 10.46 78 276795 8198 79459317
Bronchial anastomosis complication 28.60 10.46 10 276863 52 79467463
Phaeohyphomycotic brain abscess 28.60 10.46 10 276863 52 79467463
Product quality issue 28.58 10.46 46 276827 33894 79433621
Dysarthria 28.55 10.46 129 276744 67493 79400022
Blood iron decreased 28.53 10.46 9 276864 15425 79452090
Peripheral coldness 28.32 10.46 10 276863 15960 79451555
Pancreatitis acute 28.32 10.46 280 276593 49324 79418191
Herpes simplex test positive 28.31 10.46 18 276855 412 79467103
Thyroid disorder 28.28 10.46 7 276866 14072 79453443
Renal haemorrhage 28.28 10.46 37 276836 2219 79465296
Lymphadenopathy mediastinal 28.24 10.46 53 276820 4343 79463172
Urinary tract infection pseudomonal 28.19 10.46 33 276840 1765 79465750
Musculoskeletal discomfort 28.09 10.46 17 276856 19818 79447697
Emphysematous cholecystitis 27.99 10.46 10 276863 56 79467459
Renal vessel disorder 27.98 10.46 16 276857 300 79467215
SARS-CoV-2 antibody test positive 27.97 10.46 18 276855 421 79467094
Bronchospasm 27.94 10.46 27 276846 24832 79442683
Burkitt's lymphoma 27.91 10.46 12 276861 117 79467398
Gastrointestinal lymphoma 27.86 10.46 13 276860 156 79467359
Mycoplasma test positive 27.85 10.46 14 276859 200 79467315
Orthobunyavirus test positive 27.84 10.46 7 276866 7 79467508
Catatonia 27.81 10.46 80 276793 8676 79458839
Intervertebral disc degeneration 27.80 10.46 10 276863 15775 79451740
Intracranial infection 27.80 10.46 11 276862 85 79467430
Roseolovirus test positive 27.73 10.46 14 276859 202 79467313
Nephrosclerosis 27.72 10.46 33 276840 1797 79465718
Liver function test abnormal 27.68 10.46 344 276529 64131 79403384
Kaposi sarcoma inflammatory cytokine syndrome 27.67 10.46 8 276865 19 79467496
Graft ischaemia 27.64 10.46 9 276864 36 79467479
Eating disorder 27.59 10.46 19 276854 20678 79446837
Treatment failure 27.52 10.46 421 276452 170065 79297450
Central nervous system vasculitis 27.52 10.46 29 276844 1379 79466136
Postoperative thoracic procedure complication 27.47 10.46 11 276862 88 79467427
Propionibacterium infection 27.47 10.46 16 276857 311 79467204
Superinfection viral 27.44 10.46 9 276864 37 79467478
Genital herpes 27.41 10.46 35 276838 2049 79465466
Neuralgia 27.41 10.46 46 276827 33338 79434177
Hepatic cyst infection 27.36 10.46 13 276860 163 79467352
Deep vein thrombosis 27.27 10.46 278 276595 120641 79346874
Skin discolouration 27.27 10.46 64 276809 40970 79426545
Wound infection fungal 27.24 10.46 14 276859 210 79467305
Immunosuppression 27.18 10.46 102 276771 12701 79454814
Gastroenteritis 27.11 10.46 207 276666 33875 79433640
Restrictive allograft syndrome 27.10 10.46 8 276865 21 79467494
Protein urine present 27.06 10.46 87 276786 10025 79457490
Therapy partial responder 27.05 10.46 126 276747 17271 79450244
Diabetic ketoacidosis 27.00 10.46 207 276666 33915 79433600
Viral skin infection 26.94 10.46 11 276862 93 79467422
Middle insomnia 26.93 10.46 11 276862 16058 79451457
Hepatic haematoma 26.92 10.46 23 276850 838 79466677
Hepatic artery aneurysm 26.89 10.46 9 276864 40 79467475
Abdominal wall haemorrhage 26.88 10.46 21 276852 673 79466842
Urinary tract candidiasis 26.87 10.46 22 276851 755 79466760
Complications of transplanted pancreas 26.83 10.46 8 276865 22 79467493
Papule 26.82 10.46 71 276802 7336 79460179
Hyperplasia 26.82 10.46 27 276846 1216 79466299
Lymphadenopathy 26.82 10.46 293 276580 52954 79414561
Prescribed underdose 26.78 10.46 38 276835 29476 79438039
Hyperuricaemia 26.73 10.46 96 276777 11703 79455812
Anaplastic large cell lymphoma T- and null-cell types 26.72 10.46 12 276861 131 79467384
Prostatic abscess 26.66 10.46 17 276856 391 79467124
Sleep apnoea syndrome 26.63 10.46 54 276819 36424 79431091
Subcutaneous emphysema 26.60 10.46 32 276841 1762 79465753
Acinetobacter bacteraemia 26.57 10.46 15 276858 274 79467241
Escherichia pyelonephritis 26.56 10.46 19 276854 531 79466984
Abnormal behaviour 26.52 10.46 54 276819 36367 79431148
Vena cava injury 26.37 10.46 16 276857 336 79467179
Human herpes virus 8 test positive 26.36 10.46 9 276864 43 79467472
Encephalitis fungal 26.35 10.46 13 276860 178 79467337
Lower limb fracture 26.34 10.46 25 276848 23190 79444325
Immune thrombocytopenia 26.26 10.46 127 276746 17678 79449837
Spinal fracture 26.24 10.46 15 276858 18039 79449476
Acute allograft nephropathy 26.19 10.46 9 276864 44 79467471
Obstructive airways disorder 26.15 10.46 43 276830 31416 79436099
Lung adenocarcinoma 26.10 10.46 73 276800 7791 79459724
Cyclosporidium infection 26.09 10.46 7 276866 11 79467504
Back injury 26.04 10.46 3 276870 10520 79456995
Upper limb fracture 26.01 10.46 15 276858 17952 79449563
Increased appetite 26.00 10.46 5 276868 11973 79455542
Petechiae 25.96 10.46 20 276853 20545 79446970
Enterobacter pneumonia 25.94 10.46 12 276861 141 79467374
Pharyngeal oedema 25.91 10.46 12 276861 16260 79451255
Adenovirus test positive 25.87 10.46 10 276863 72 79467443
Head discomfort 25.86 10.46 9 276864 14493 79453022
Removal of renal transplant 25.85 10.46 8 276865 26 79467489
Fungal peritonitis 25.79 10.46 25 276848 1075 79466440
Fear 25.75 10.46 23 276850 21963 79445552
Oral hairy leukoplakia 25.72 10.46 7 276866 12 79467503
Rabies 25.72 10.46 7 276866 12 79467503
Bone tuberculosis 25.66 10.46 19 276854 561 79466954
Metastases to lymph nodes 25.63 10.46 87 276786 10310 79457205
Blood immunoglobulin G decreased 25.61 10.46 44 276829 3365 79464150
Enterococcus test positive 25.59 10.46 34 276839 2070 79465445
Squamous cell carcinoma of the vulva 25.58 10.46 6 276867 3 79467512
Laboratory test abnormal 25.57 10.46 36 276837 28012 79439503
Sinus bradycardia 25.50 10.46 30 276843 25217 79442298
Shock 25.44 10.46 247 276626 43301 79424214
Acute pulmonary histoplasmosis 25.38 10.46 14 276859 244 79467271
Listeriosis 25.30 10.46 35 276838 2215 79465300
Tuberculosis of genitourinary system 25.25 10.46 9 276864 50 79467465
Portal vein occlusion 25.25 10.46 9 276864 50 79467465
Meningitis 25.25 10.46 82 276791 9500 79458015
Pulmonary mass 25.17 10.46 180 276693 28854 79438661
Continuous haemodiafiltration 25.17 10.46 33 276840 1983 79465532
Hydrocephalus 25.13 10.46 78 276795 8822 79458693
Cutaneous mucormycosis 25.12 10.46 13 276860 198 79467317
Blood pressure diastolic abnormal 25.11 10.46 18 276855 19184 79448331
Necrotising colitis 25.07 10.46 24 276849 1016 79466499
Visual impairment 25.05 10.46 202 276671 91929 79375586
Necrotising fasciitis 25.04 10.46 61 276812 5989 79461526
Hepatitis G 25.02 10.46 7 276866 14 79467501
Fibromatosis colli of infancy 25.02 10.46 7 276866 14 79467501
Acquired plagiocephaly 25.02 10.46 7 276866 14 79467501
Hallucination, auditory 25.02 10.46 21 276852 20672 79446843
Pleural adhesion 24.98 10.46 15 276858 309 79467206
Sinus tachycardia 24.98 10.46 57 276816 36851 79430664
Cow pox 24.97 10.46 8 276865 30 79467485
Lymphadenitis fungal 24.95 10.46 6 276867 4 79467511
Moyamoya disease 24.86 10.46 10 276863 81 79467434
Cerebral ventricle collapse 24.83 10.46 11 276862 116 79467399
Pneumococcal infection 24.80 10.46 23 276850 935 79466580
Ankle fracture 24.80 10.46 14 276859 16955 79450560
Face oedema 24.77 10.46 37 276836 28099 79439416
IVth nerve paralysis 24.74 10.46 12 276861 158 79467357
Hyperparathyroidism 24.73 10.46 42 276831 3182 79464333
Device leakage 24.72 10.46 4 276869 10852 79456663
Trichophytic granuloma 24.67 10.46 9 276864 54 79467461
Beta-N-acetyl-D-glucosaminidase increased 24.67 10.46 9 276864 54 79467461
Angioimmunoblastic T-cell lymphoma 24.67 10.46 17 276856 447 79467068
Sinusitis aspergillus 24.65 10.46 14 276859 259 79467256
Abscess 24.58 10.46 150 276723 22801 79444714
Ear pain 24.56 10.46 48 276825 32821 79434694
Mouth ulceration 24.55 10.46 222 276651 38172 79429343
Diffuse large B-cell lymphoma stage IV 24.53 10.46 18 276855 524 79466991
Disseminated Bacillus Calmette-Guerin infection 24.45 10.46 13 276860 210 79467305
Renal injury 24.44 10.46 120 276753 16807 79450708
Post procedural complication 24.43 10.46 154 276719 23675 79443840
Conjunctival melanoma 24.38 10.46 6 276867 5 79467510
Pulmonary arterial hypertension 24.31 10.46 38 276835 28328 79439187
Dry eye 24.22 10.46 58 276815 36873 79430642
Nodular melanoma 24.21 10.46 12 276861 166 79467349
Perihepatic abscess 24.21 10.46 12 276861 166 79467349
Cell-mediated immune deficiency 24.10 10.46 11 276862 125 79467390
Abdominal wound dehiscence 24.08 10.46 14 276859 271 79467244
Chest wall abscess 24.07 10.46 13 276860 217 79467298
Steroid withdrawal syndrome 24.07 10.46 20 276853 701 79466814
Mastitis bacterial 24.00 10.46 9 276864 59 79467456
Vascular anastomotic haemorrhage 23.99 10.46 14 276859 273 79467242
Escherichia test positive 23.88 10.46 41 276832 3134 79464381
Conjunctival neoplasm 23.86 10.46 6 276867 6 79467509
Sinusitis fungal 23.86 10.46 35 276838 2339 79465176
Endocarditis staphylococcal 23.71 10.46 20 276853 716 79466799
Dermatitis allergic 23.70 10.46 17 276856 18113 79449402
Bladder transitional cell carcinoma 23.69 10.46 37 276836 2613 79464902
Hepatic infection fungal 23.65 10.46 13 276860 225 79467290
Capillary leak syndrome 23.59 10.46 46 276827 3879 79463636
Meningoencephalitis bacterial 23.55 10.46 13 276860 227 79467288
Nocturia 23.53 10.46 9 276864 13672 79453843
Renal cortical necrosis 23.53 10.46 15 276858 345 79467170
Pneumonia necrotising 23.50 10.46 25 276848 1202 79466313
Biliary fistula 23.48 10.46 10 276863 95 79467420
Eye disorder 23.45 10.46 28 276845 23384 79444131
Temperature intolerance 23.44 10.46 3 276870 9702 79457813
Bacterial colitis 23.39 10.46 10 276863 96 79467419
Musculoskeletal chest pain 23.36 10.46 31 276842 24733 79442782
Periorbital cellulitis 23.34 10.46 22 276851 913 79466602
Optic pathway injury 23.33 10.46 5 276868 0 79467515
Acquired porokeratosis 23.33 10.46 5 276868 0 79467515
Seasonal allergy 23.32 10.46 14 276859 16392 79451123
Liver injury 23.31 10.46 109 276764 56505 79411010
Myoclonic dystonia 23.26 10.46 9 276864 65 79467450
Pulmonary fibrosis 23.22 10.46 77 276796 44035 79423480
Stomatococcal infection 23.20 10.46 14 276859 291 79467224
Pneumonia adenoviral 23.16 10.46 17 276856 495 79467020
Intrauterine infection 23.15 10.46 9 276864 66 79467449
Cytokine storm 23.09 10.46 23 276850 1023 79466492
Weight fluctuation 23.08 10.46 6 276867 11669 79455846
Refractoriness to platelet transfusion 23.07 10.46 11 276862 139 79467376
Haemorrhage intracranial 23.07 10.46 163 276710 26030 79441485
Pneumonia acinetobacter 23.06 10.46 12 276861 185 79467330
Neuropsychiatric lupus 23.06 10.46 12 276861 185 79467330
Cholangitis infective 23.06 10.46 19 276854 658 79466857
Arterioenteric fistula 23.03 10.46 7 276866 21 79467494
Odynophagia 23.02 10.46 89 276784 11238 79456277
Dyschromatopsia 23.01 10.46 21 276852 836 79466679
Serositis 22.99 10.46 21 276852 837 79466678
Coordination abnormal 22.93 10.46 16 276857 17296 79450219
Viral mutation identified 22.93 10.46 45 276828 3813 79463702
Neutropenia 22.92 10.46 1220 275653 286490 79181025
Bone marrow oedema 22.92 10.46 29 276844 1682 79465833
Mucosal hypertrophy 22.92 10.46 9 276864 68 79467447
Renal ischaemia 22.83 10.46 24 276849 1138 79466377
Morphoea 22.82 10.46 16 276857 433 79467082
Uraemic encephalopathy 22.81 10.46 19 276854 668 79466847
Injection site urticaria 22.80 10.46 8 276865 12818 79454697
Cardiac failure 22.79 10.46 389 276484 154453 79313062
Angiopathy 22.78 10.46 65 276808 7017 79460498
Renal tubular dysfunction 22.77 10.46 20 276853 757 79466758
Renal cell carcinoma 22.76 10.46 62 276811 6516 79460999
Disseminated strongyloidiasis 22.72 10.46 13 276860 244 79467271
Squamous cell carcinoma of the oral cavity 22.70 10.46 17 276856 511 79467004
Peritonitis bacterial 22.67 10.46 79 276794 9488 79458027
Tongue ulceration 22.64 10.46 47 276826 4146 79463369
Lymphorrhoea 22.53 10.46 11 276862 147 79467368
Retinal ischaemia 22.52 10.46 20 276853 768 79466747
Hyperoxaluria 22.46 10.46 14 276859 309 79467206
Viral diarrhoea 22.46 10.46 15 276858 374 79467141
Device related bacteraemia 22.46 10.46 19 276854 683 79466832
Oral pain 22.43 10.46 48 276825 31750 79435765
Soft tissue sarcoma 22.39 10.46 12 276861 197 79467318
Colitis microscopic 22.33 10.46 5 276868 10763 79456752
Emotional disorder 22.31 10.46 11 276862 14376 79453139
Skin plaque 22.31 10.46 85 276788 10660 79456855
Second primary malignancy 22.21 10.46 11 276862 14339 79453176
Placenta accreta 22.18 10.46 12 276861 201 79467314
Pseudomonal sepsis 22.17 10.46 59 276814 6115 79461400
Perineal cyst 22.17 10.46 13 276860 256 79467259
Acute lymphocytic leukaemia recurrent 22.14 10.46 50 276823 4674 79462841
Protein-losing gastroenteropathy 22.13 10.46 18 276855 612 79466903
Eschar 22.03 10.46 25 276848 1293 79466222
Thrombocytopenia 21.98 10.46 1129 275744 264130 79203385
Rash maculo-papular 21.91 10.46 110 276763 55968 79411547
Anastomotic haemorrhage 21.86 10.46 13 276860 263 79467252
Affect lability 21.85 10.46 6 276867 11253 79456262
Diarrhoea infectious 21.84 10.46 28 276845 1646 79465869
Papilloedema 21.82 10.46 59 276814 6174 79461341
Taste disorder 21.80 10.46 14 276859 15809 79451706
Osteoporosis 21.80 10.46 105 276768 54007 79413508
Extrapyramidal disorder 21.80 10.46 28 276845 22651 79444864
Lupus enteritis 21.79 10.46 8 276865 49 79467466
Type 1 diabetes mellitus 21.77 10.46 63 276810 6856 79460659
Blood urea increased 21.67 10.46 262 276611 48528 79418987
Infective scleritis 21.66 10.46 8 276865 50 79467465
Staphylococcal scalded skin syndrome 21.65 10.46 15 276858 398 79467117
Blood parathyroid hormone decreased 21.63 10.46 5 276868 10531 79456984
Acquired macroglossia 21.56 10.46 12 276861 213 79467302
Blood creatinine abnormal 21.48 10.46 50 276823 4767 79462748
Electrocardiogram abnormal 21.48 10.46 16 276857 16721 79450794
Genitourinary tract infection 21.47 10.46 13 276860 272 79467243
Tick-borne viral encephalitis 21.47 10.46 11 276862 164 79467351
Transmission of an infectious agent via transplant 21.45 10.46 6 276867 12 79467503
Septic pulmonary embolism 21.43 10.46 10 276863 120 79467395
Multiple allergies 21.41 10.46 5 276868 10455 79457060
Aspergillosis oral 21.39 10.46 8 276865 52 79467463
Asphyxia 21.37 10.46 7 276866 11713 79455802
Fluoride increased 21.37 10.46 9 276864 83 79467432
Blood lactate dehydrogenase increased 21.35 10.46 219 276654 38951 79428564
Cyanosis 21.32 10.46 34 276839 25148 79442367
Anal incontinence 21.28 10.46 19 276854 18149 79449366
Cytomegalovirus mucocutaneous ulcer 21.27 10.46 9 276864 84 79467431
Schistosomiasis 21.27 10.46 8 276865 53 79467462
Pyuria 21.25 10.46 33 276840 2319 79465196
Intra-abdominal haemorrhage 21.22 10.46 48 276825 4492 79463023
Thirst 21.19 10.46 20 276853 18599 79448916
Rhesus antigen positive 21.14 10.46 10 276863 124 79467391
Leukaemia recurrent 21.10 10.46 36 276837 2738 79464777
Graft haemorrhage 21.09 10.46 9 276864 86 79467429
Rash erythematous 21.07 10.46 116 276757 57653 79409862
Red blood cell schistocytes present 21.05 10.46 17 276856 572 79466943
Mental impairment 21.02 10.46 21 276852 19015 79448500
Solid organ transplant rejection 20.99 10.46 5 276868 3 79467512
Disseminated paracoccidioidomycosis 20.99 10.46 5 276868 3 79467512
Aphonia 20.96 10.46 5 276868 10307 79457208
Drug level abnormal 20.93 10.46 14 276859 350 79467165
Eosinophilic oesophagitis 20.92 10.46 17 276856 577 79466938
Gastrointestinal ulcer perforation 20.89 10.46 8 276865 56 79467459
Gastroduodenal ulcer 20.88 10.46 16 276857 498 79467017
Pyogenic granuloma 20.85 10.46 16 276857 499 79467016
Productive cough 20.78 10.46 201 276672 88130 79379385
Brucellosis 20.73 10.46 10 276863 130 79467385
NPM1 gene mutation 20.73 10.46 10 276863 130 79467385
Chronic inflammatory demyelinating polyradiculoneuropathy 20.70 10.46 23 276850 1162 79466353
Distributive shock 20.61 10.46 35 276838 2652 79464863
Fluorosis 20.52 10.46 10 276863 133 79467382
Pulmonary cavitation 20.51 10.46 27 276846 1629 79465886
Vanishing bile duct syndrome 20.51 10.46 28 276845 1750 79465765
Sweat gland tumour 20.50 10.46 16 276857 512 79467003
Abnormal dreams 20.49 10.46 7 276866 11405 79456110
Walking aid user 20.47 10.46 5 276868 10143 79457372
Herpes simplex viraemia 20.46 10.46 15 276858 436 79467079
Fungating wound 20.41 10.46 7 276866 34 79467481
Disseminated varicella 20.41 10.46 5 276868 4 79467511
Enterobacter bacteraemia 20.40 10.46 20 276853 872 79466643
Congenital cystic kidney disease 20.39 10.46 13 276860 299 79467216
Lip squamous cell carcinoma 20.39 10.46 13 276860 299 79467216
Fibrosis 20.37 10.46 52 276821 5257 79462258
Pneumonia pneumococcal 20.35 10.46 44 276829 3993 79463522
Gastric perforation 20.35 10.46 44 276829 3993 79463522
Renal aneurysm 20.34 10.46 11 276862 184 79467331
Adenocarcinoma 20.34 10.46 43 276830 3843 79463672
Cytomegalovirus gastrointestinal ulcer 20.31 10.46 8 276865 61 79467454
Paraspinal abscess 20.29 10.46 11 276862 185 79467330
Genital herpes simplex 20.29 10.46 14 276859 369 79467146
Gastric ulcer haemorrhage, obstructive 20.26 10.46 6 276867 16 79467499
Mental status changes 20.25 10.46 336 276537 66623 79400892
Pathergy reaction 20.25 10.46 7 276866 35 79467480
Product storage error 20.20 10.46 16 276857 16210 79451305
Movement disorder 20.20 10.46 40 276833 27219 79440296
Hypoaldosteronism 20.19 10.46 14 276859 372 79467143
Tooth abscess 20.16 10.46 16 276857 16194 79451321
Macular degeneration 20.16 10.46 7 276866 11289 79456226
Transplant 20.13 10.46 21 276852 987 79466528
Metastasis 20.08 10.46 61 276812 6819 79460696
Reperfusion injury 20.03 10.46 11 276862 190 79467325
Generalised tonic-clonic seizure 20.03 10.46 237 276636 43673 79423842
Drug tolerance decreased 20.01 10.46 10 276863 12968 79454547
Ageusia 19.96 10.46 17 276856 16615 79450900
Diabetic macroangiopathy 19.95 10.46 10 276863 142 79467373
Urine protein/creatinine ratio increased 19.94 10.46 23 276850 1211 79466304
Pseudohypoaldosteronism 19.93 10.46 7 276866 37 79467478
Ear discomfort 19.91 10.46 3 276870 8580 79458935
Autoimmune disorder 19.91 10.46 17 276856 16595 79450920
Urogenital infection bacterial 19.90 10.46 9 276864 100 79467415
Incisional hernia 19.89 10.46 33 276840 2453 79465062
Granulicatella bacteraemia 19.88 10.46 5 276868 5 79467510
T-cell lymphoma stage IV 19.88 10.46 10 276863 143 79467372
Tenosynovitis 19.79 10.46 15 276858 15539 79451976
Salmonellosis 19.79 10.46 28 276845 1810 79465705
Pneumothorax 19.79 10.46 167 276706 28156 79439359
Herpes oesophagitis 19.77 10.46 14 276859 385 79467130
Colitis 19.71 10.46 361 276512 72946 79394569
Cholangiocarcinoma 19.69 10.46 33 276840 2473 79465042
Renal adenoma 19.62 10.46 7 276866 39 79467476
Erosive duodenitis 19.55 10.46 30 276843 2087 79465428
Surgery 19.53 10.46 54 276819 32712 79434803
Lymphangiectasia 19.51 10.46 9 276864 105 79467410
Pancreatic leak 19.50 10.46 6 276867 19 79467496
Campylobacter infection 19.50 10.46 28 276845 1835 79465680
Blood albumin increased 19.49 10.46 25 276848 1470 79466045
Toxic leukoencephalopathy 19.48 10.46 22 276851 1132 79466383
Hernial eventration 19.46 10.46 8 276865 69 79467446
Anhedonia 19.43 10.46 14 276859 14884 79452631
Arterial thrombosis 19.42 10.46 34 276839 2640 79464875
Respiratory rate increased 19.41 10.46 28 276845 21572 79445943
Biliary tract infection fungal 19.41 10.46 5 276868 6 79467509
Arteriovenous fistula aneurysm 19.41 10.46 5 276868 6 79467509
Cyst 19.41 10.46 12 276861 13828 79453687
Arteriovenous fistula thrombosis 19.39 10.46 16 276857 555 79466960
Herpes simplex pneumonia 19.36 10.46 8 276865 70 79467445
Lymphoid tissue hyperplasia 19.33 10.46 12 276861 263 79467252
Oral discomfort 19.32 10.46 5 276868 9755 79457760
Prostatic specific antigen increased 19.30 10.46 6 276867 10380 79457135
Haemoperitoneum 19.28 10.46 45 276828 4298 79463217
Cytomegalovirus myocarditis 19.27 10.46 6 276867 20 79467495
Faecaloma 19.25 10.46 8 276865 11556 79455959
Eosinophilic colitis 19.24 10.46 15 276858 479 79467036
Renal-limited thrombotic microangiopathy 19.23 10.46 10 276863 154 79467361
Acarodermatitis 19.21 10.46 24 276849 1374 79466141
Platelet count increased 19.21 10.46 30 276843 22376 79445139
Pneumonia haemophilus 19.20 10.46 22 276851 1150 79466365
Renal artery thrombosis 19.11 10.46 15 276858 484 79467031
Renal cell carcinoma stage I 19.05 10.46 7 276866 43 79467472
Necrosis of artery 18.98 10.46 5 276868 7 79467508
Lung adenocarcinoma stage IV 18.94 10.46 12 276861 273 79467242
Chylothorax 18.90 10.46 18 276855 757 79466758
Renal lymphocele 18.86 10.46 9 276864 114 79467401
Penile ulceration 18.86 10.46 14 276859 415 79467100
Cerebral cyst 18.86 10.46 14 276859 415 79467100
Transaminases increased 18.86 10.46 268 276605 51475 79416040
Electrocardiogram QRS complex prolonged 18.84 10.46 7 276866 10826 79456689
Thyroid tuberculosis 18.83 10.46 6 276867 22 79467493
Device related infection 18.82 10.46 192 276681 34102 79433413
Tongue necrosis 18.78 10.46 7 276866 45 79467470
Chronic sinusitis 18.68 10.46 11 276862 13015 79454500
Bile duct cancer recurrent 18.67 10.46 4 276869 0 79467515
Mesenteric fibrosis 18.67 10.46 4 276869 0 79467515
Multiple organ transplant rejection 18.67 10.46 4 276869 0 79467515
Muscle rigidity 18.64 10.46 25 276848 19857 79447658
Product prescribing error 18.61 10.46 86 276787 44727 79422788
Pancreatic pseudocyst haemorrhage 18.58 10.46 5 276868 8 79467507
Seroconversion test negative 18.58 10.46 5 276868 8 79467507
Failure to thrive 18.58 10.46 86 276787 11758 79455757
Viral sepsis 18.56 10.46 10 276863 166 79467349
Renal atrophy 18.47 10.46 27 276846 1798 79465717
Secretion discharge 18.47 10.46 15 276858 15007 79452508
Cryptitis 18.45 10.46 12 276861 286 79467229
Focal myositis 18.43 10.46 6 276867 24 79467491
Nocardia sepsis 18.43 10.46 6 276867 24 79467491
Bone marrow granuloma 18.43 10.46 6 276867 24 79467491
Eye infection fungal 18.34 10.46 15 276858 514 79467001
Facial pain 18.32 10.46 10 276863 12340 79455175
Bradyphrenia 18.30 10.46 7 276866 10633 79456882
Lymph node tuberculosis 18.26 10.46 20 276853 994 79466521
Pelvic pain 18.22 10.46 12 276861 13369 79454146
Pleomorphism 18.22 10.46 5 276868 9 79467506
Renal arteritis 18.22 10.46 5 276868 9 79467506
Jejunal perforation 18.19 10.46 13 276860 363 79467152
Myelitis 18.15 10.46 31 276842 2360 79465155
Upper respiratory tract inflammation 18.12 10.46 42 276831 3993 79463522
Capnocytophaga infection 18.06 10.46 9 276864 126 79467389
Central nervous system immune reconstitution inflammatory response 18.04 10.46 7 276866 51 79467464
Familial mediterranean fever 17.99 10.46 10 276863 177 79467338
Fracture 17.93 10.46 30 276843 21771 79445744
Acute disseminated encephalomyelitis 17.91 10.46 12 276861 301 79467214
Hyperamylasaemia 17.90 10.46 21 276852 1126 79466389
Thrombosis 17.88 10.46 196 276677 83904 79383611
Complications of intestinal transplant 17.87 10.46 5 276868 10 79467505
Pulmonary thrombosis 17.85 10.46 10 276863 12161 79455354
Avian influenza 17.84 10.46 8 276865 87 79467428
Superinfection 17.76 10.46 47 276826 4855 79462660
Oral allergy syndrome 17.76 10.46 8 276865 88 79467427
Pneumonia respiratory syncytial viral 17.76 10.46 27 276846 1863 79465652
Dislocation of vertebra 17.73 10.46 3 276870 7877 79459638
Hair follicle tumour benign 17.72 10.46 14 276859 456 79467059
Acute respiratory failure 17.72 10.46 298 276575 59243 79408272
Ventricular tachycardia 17.70 10.46 80 276793 41855 79425660
Seroma 17.69 10.46 30 276843 2270 79465245
Corynebacterium bacteraemia 17.69 10.46 6 276867 28 79467487
Appendicolith 17.67 10.46 4 276869 8547 79458968
Injection site induration 17.67 10.46 6 276867 9813 79457702
Reactive gastropathy 17.59 10.46 15 276858 545 79466970
Intestinal ulcer 17.59 10.46 28 276845 2010 79465505
Incontinence 17.59 10.46 14 276859 14150 79453365
Yersinia infection 17.59 10.46 7 276866 55 79467460
Giardiasis 17.57 10.46 12 276861 311 79467204
Cytotoxic oedema 17.55 10.46 13 276860 384 79467131
Endocarditis bacterial 17.52 10.46 24 276849 1505 79466010
Hypertriglyceridaemia 17.46 10.46 89 276784 12651 79454864
Infective thrombosis 17.45 10.46 8 276865 92 79467423
Hospice care 17.41 10.46 7 276866 10317 79457198
Small cell carcinoma 17.40 10.46 12 276861 316 79467199
Foot fracture 17.39 10.46 31 276842 21950 79445565
Severe acute respiratory syndrome 17.34 10.46 9 276864 138 79467377
Tonsillitis 17.28 10.46 57 276816 6657 79460858
Genital disorder 17.26 10.46 5 276868 12 79467503
Neutrophil morphology abnormal 17.22 10.46 8 276865 95 79467420
Flavobacterium infection 17.22 10.46 8 276865 95 79467420
Pneumonia aspiration 17.22 10.46 149 276724 66818 79400697
Sneezing 17.22 10.46 26 276847 19657 79447858
Plasmapheresis 17.20 10.46 16 276857 653 79466862
Tonsillar hypertrophy 17.12 10.46 24 276849 1538 79465977
Skin abrasion 17.09 10.46 13 276860 13443 79454072
Diffuse large B-cell lymphoma stage III 17.07 10.46 8 276865 97 79467418
Sebaceous gland disorder 17.06 10.46 7 276866 60 79467455
Epileptic encephalopathy 17.06 10.46 14 276859 482 79467033
Peripheral venous disease 17.06 10.46 18 276855 15891 79451624
Hypertensive encephalopathy 17.05 10.46 19 276854 963 79466552
Lung infiltration 17.03 10.46 137 276736 22775 79444740
Muscle tightness 17.02 10.46 12 276861 12902 79454613
Myopathy toxic 16.96 10.46 20 276853 1078 79466437
Strabismus 16.96 10.46 31 276842 2490 79465025
Transfusion 16.95 10.46 30 276843 21300 79446215
Rash macular 16.95 10.46 48 276825 28851 79438664
Steatohepatitis 16.92 10.46 19 276854 971 79466544
Gastroenteritis rotavirus 16.87 10.46 13 276860 408 79467107
Myocarditis toxoplasmal 16.86 10.46 7 276866 62 79467453
Stenotrophomonas bacteraemia 16.86 10.46 7 276866 62 79467453
Blood sodium decreased 16.86 10.46 59 276814 33196 79434319
Feeling jittery 16.84 10.46 12 276861 12829 79454686
Glomerulonephritis minimal lesion 16.81 10.46 17 276856 770 79466745
Gingival bleeding 16.80 10.46 19 276854 16257 79451258
Concussion 16.77 10.46 6 276867 9497 79458018
Cardiac autonomic neuropathy 16.77 10.46 7 276866 63 79467452
Streptococcal bacteraemia 16.71 10.46 38 276835 3568 79463947
Arterial disorder 16.71 10.46 27 276846 1963 79465552
Oral papilloma 16.71 10.46 5 276868 14 79467501
Metastases to salivary gland 16.71 10.46 5 276868 14 79467501
Blood pressure abnormal 16.70 10.46 21 276852 17148 79450367
Synovial cyst 16.69 10.46 7 276866 10058 79457457
Pneumonia mycoplasmal 16.63 10.46 23 276850 1455 79466060
Autoimmune hepatitis 16.63 10.46 83 276790 11700 79455815
Drug trough level 16.59 10.46 6 276867 35 79467480
Sebaceous adenoma 16.59 10.46 6 276867 35 79467480
Pneumocephalus 16.57 10.46 12 276861 342 79467173
HIV infection 16.54 10.46 20 276853 1107 79466408
Ureteric obstruction 16.53 10.46 32 276841 2684 79464831
Myocarditis infectious 16.48 10.46 7 276866 66 79467449
Spontaneous intrahepatic portosystemic venous shunt 16.45 10.46 5 276868 15 79467500
Lacrimal gland enlargement 16.45 10.46 6 276867 36 79467479
Erythrophagocytosis 16.45 10.46 6 276867 36 79467479
Enterocolitis fungal 16.44 10.46 4 276869 3 79467512
Normal newborn 16.41 10.46 58 276815 7014 79460501
Erectile dysfunction 16.40 10.46 16 276857 14648 79452867
Encephalitis Japanese B 16.39 10.46 7 276866 67 79467448
Herpes simplex meningoencephalitis 16.39 10.46 7 276866 67 79467448
Optic discs blurred 16.39 10.46 7 276866 67 79467448
Haemoglobin decreased 16.38 10.46 618 276255 221501 79246014
Gastric ulcer 16.36 10.46 185 276688 33720 79433795
Inflammation 16.35 10.46 228 276645 93525 79373990
Diverticulitis 16.34 10.46 93 276780 45843 79421672
Pleomorphic malignant fibrous histiocytoma 16.31 10.46 6 276867 37 79467478
Page kidney 16.30 10.46 7 276866 68 79467447
Dizziness postural 16.21 10.46 10 276863 11539 79455976
Peripancreatic fluid collection 16.21 10.46 7 276866 69 79467446
Arteritis 16.21 10.46 18 276855 909 79466606
Vaginal haemorrhage 16.18 10.46 32 276841 21785 79445730
Drug tolerance 16.14 10.46 5 276868 8670 79458845
Blood culture positive 16.14 10.46 65 276808 8364 79459151
Arteriosclerosis coronary artery 16.11 10.46 23 276850 17793 79449722
Hyperthyroidism 16.11 10.46 33 276840 22176 79445339
Blood loss anaemia 16.10 10.46 18 276855 15480 79452035
Post herpetic neuralgia 16.10 10.46 31 276842 2590 79464925
Cystitis 16.05 10.46 112 276761 52620 79414895
Acid base balance abnormal 16.04 10.46 12 276861 360 79467155
Laryngeal mass 16.04 10.46 7 276866 71 79467444
Eosinophilia 16.02 10.46 92 276781 45253 79422262
Papilloma 15.98 10.46 12 276861 362 79467153
Vascular pseudoaneurysm ruptured 15.96 10.46 9 276864 164 79467351
Orbital apex syndrome 15.95 10.46 7 276866 72 79467443
Moraxella infection 15.93 10.46 15 276858 622 79466893
Blood phosphorus increased 15.91 10.46 8 276865 10339 79457176
Fascioliasis 15.91 10.46 4 276869 4 79467511
Myocarditis mycotic 15.91 10.46 4 276869 4 79467511
Extranodal marginal zone B-cell lymphoma (MALT type) stage IV 15.91 10.46 4 276869 4 79467511
Insulin resistant diabetes 15.91 10.46 4 276869 4 79467511
Granulocytopenia 15.91 10.46 10 276863 11421 79456094
Body height decreased 15.87 10.46 5 276868 8575 79458940
Therapeutic response shortened 15.86 10.46 19 276854 15844 79451671
Granuloma skin 15.84 10.46 6 276867 9168 79458347
Pericarditis infective 15.84 10.46 10 276863 226 79467289
Nephrolithiasis 15.83 10.46 114 276759 53177 79414338
Hepatic infection bacterial 15.79 10.46 6 276867 41 79467474
Sarcoma metastatic 15.78 10.46 7 276866 74 79467441
Portal vein stenosis 15.77 10.46 5 276868 18 79467497
Mesangioproliferative glomerulonephritis 15.75 10.46 8 276865 117 79467398
Impaired quality of life 15.74 10.46 16 276857 14370 79453145
Urinary tract infection 15.71 10.46 1131 275742 273381 79194134
Coronary artery occlusion 15.68 10.46 18 276855 15297 79452218
Scopulariopsis infection 15.63 10.46 8 276865 119 79467396
Anastomotic complication 15.61 10.46 13 276860 457 79467058
Osteonecrosis 15.61 10.46 171 276702 30924 79436591
Cytokine release syndrome 15.60 10.46 68 276805 35930 79431585
Peritoneal candidiasis 15.56 10.46 5 276868 19 79467496
Splenic peliosis 15.56 10.46 5 276868 19 79467496
Arthropod bite 15.55 10.46 5 276868 8466 79459049
Chronic cutaneous lupus erythematosus 15.51 10.46 13 276860 461 79467054
Infusion site swelling 15.51 10.46 4 276869 7822 79459693
Fat necrosis 15.51 10.46 17 276856 846 79466669
Total cholesterol/HDL ratio abnormal 15.46 10.46 7 276866 78 79467437
Pharyngitis streptococcal 15.43 10.46 9 276864 10705 79456810
Ventricular extrasystoles 15.40 10.46 28 276845 19676 79447839
Herpes simplex reactivation 15.40 10.46 13 276860 466 79467049
Henoch-Schonlein purpura 15.37 10.46 31 276842 2679 79464836
Fungal test positive 15.36 10.46 19 276854 1077 79466438
Tropical spastic paresis 15.36 10.46 5 276868 20 79467495
Myelodysplastic syndrome unclassifiable 15.36 10.46 5 276868 20 79467495
Leuconostoc infection 15.36 10.46 5 276868 20 79467495
Bowen's disease 15.34 10.46 8 276865 124 79467391
Anti-GAD antibody positive 15.32 10.46 6 276867 45 79467470
Anorectal varices 15.32 10.46 6 276867 45 79467470
Abdominal abscess 15.31 10.46 57 276816 7070 79460445
Retroperitoneal lymphadenopathy 15.30 10.46 19 276854 1081 79466434
Vascular compression 15.29 10.46 14 276859 560 79466955
Hyperaesthesia 15.28 10.46 12 276861 12210 79455305
Salmonella bacteraemia 15.27 10.46 11 276862 311 79467204
Wound complication 15.26 10.46 45 276828 4948 79462567
Splenic rupture 15.25 10.46 29 276844 2400 79465115
Pseudallescheria infection 15.16 10.46 5 276868 21 79467494
Product administration error 15.15 10.46 58 276815 31788 79435727
T-cell type acute leukaemia 15.14 10.46 9 276864 182 79467333
Biliary obstruction 15.13 10.46 43 276830 4631 79462884
Hypoaesthesia oral 15.12 10.46 16 276857 14108 79453407
Incoherent 15.11 10.46 4 276869 7688 79459827
Food allergy 15.11 10.46 76 276797 10748 79456767
Parosmia 15.07 10.46 3 276870 7011 79460504
Tuberculosis of central nervous system 15.07 10.46 13 276860 480 79467035
Bronchitis fungal 15.02 10.46 4 276869 6 79467509
Giant cell myocarditis 15.02 10.46 4 276869 6 79467509
Biliary anastomosis 15.02 10.46 4 276869 6 79467509
Wound evisceration 15.00 10.46 8 276865 130 79467385
Diverticulitis intestinal perforated 14.99 10.46 10 276863 249 79467266
Blood pressure diastolic increased 14.99 10.46 17 276856 14525 79452990
Mucinous adenocarcinoma of appendix 14.98 10.46 5 276868 22 79467493
Systemic inflammatory response syndrome 14.96 10.46 79 276794 11386 79456129
Haemorrhagic pneumonia 14.95 10.46 8 276865 131 79467384
Immobile 14.95 10.46 3 276870 6970 79460545
Groin pain 14.94 10.46 14 276859 13066 79454449
Acanthosis 14.93 10.46 13 276860 486 79467029
Glomerular vascular disorder 14.92 10.46 9 276864 187 79467328
Pneumonia legionella 14.91 10.46 32 276841 2890 79464625
Poor venous access 14.90 10.46 25 276848 18124 79449391
Subarachnoid haemorrhage 14.90 10.46 140 276733 24325 79443190
Coombs positive haemolytic anaemia 14.90 10.46 19 276854 1111 79466404
Cachexia 14.90 10.46 77 276796 11006 79456509
Palatal ulcer 14.89 10.46 8 276865 132 79467383
Myocardial necrosis 14.89 10.46 13 276860 488 79467027
Injection site discolouration 14.88 10.46 4 276869 7610 79459905
Pyrexia 14.88 10.46 2625 274248 676084 78791431
Amyloidosis senile 14.88 10.46 6 276867 49 79467466
CSF culture positive 14.88 10.46 6 276867 49 79467466
Acinetobacter test positive 14.85 10.46 10 276863 253 79467262
Anal ulcer 14.85 10.46 21 276852 1357 79466158
High-grade B-cell lymphoma 14.79 10.46 8 276865 134 79467381
Tooth extraction 14.78 10.46 10 276863 10985 79456530
Colon injury 14.78 10.46 10 276863 255 79467260
Increased tendency to bruise 14.77 10.46 9 276864 10455 79457060
Bladder transitional cell carcinoma stage III 14.77 10.46 6 276867 50 79467465
Upper motor neurone lesion 14.75 10.46 10 276863 256 79467259
Unmasking of previously unidentified disease 14.74 10.46 26 276847 2031 79465484
Peliosis hepatis 14.73 10.46 8 276865 135 79467380
Procedural pneumothorax 14.72 10.46 7 276866 88 79467427
Cytomegalovirus duodenitis 14.72 10.46 7 276866 88 79467427
Delirium 14.69 10.46 206 276667 84421 79383094
Parvovirus B19 test positive 14.68 10.46 8 276865 136 79467379
Purpura fulminans 14.67 10.46 9 276864 193 79467322
Epstein-Barr virus antigen positive 14.65 10.46 7 276866 89 79467426
Vestibular nystagmus 14.64 10.46 4 276869 7 79467508
St. Louis encephalitis 14.64 10.46 4 276869 7 79467508
Endocarditis viral 14.64 10.46 4 276869 7 79467508
Beta 2 microglobulin urine increased 14.63 10.46 8 276865 137 79467378
Necrotising fasciitis fungal 14.63 10.46 5 276868 24 79467491
Splenic haemorrhage 14.62 10.46 15 276858 691 79466824
Condition aggravated 14.61 10.46 1520 275353 499604 78967911
Gastrointestinal pain 14.59 10.46 8 276865 9847 79457668
Haemothorax 14.54 10.46 47 276826 5431 79462084
Eye infection 14.53 10.46 12 276861 11908 79455607
Hemianopia heteronymous 14.51 10.46 7 276866 91 79467424
Lupus-like syndrome 14.50 10.46 16 276857 13841 79453674
Drug-induced liver injury 14.49 10.46 153 276720 65964 79401551
Arm amputation 14.48 10.46 8 276865 140 79467375
Keratoacanthoma 14.46 10.46 18 276855 1027 79466488
Papillary renal cell carcinoma 14.44 10.46 10 276863 265 79467250
Precursor T-lymphoblastic lymphoma/leukaemia 14.44 10.46 7 276866 92 79467423
Decubitus ulcer 14.43 10.46 20 276853 15667 79451848
Sphincter of Oddi dysfunction 14.43 10.46 12 276861 421 79467094
Product dispensing error 14.40 10.46 87 276786 13176 79454339
Vitamin D deficiency 14.38 10.46 17 276856 14262 79453253
Typhoid fever 14.37 10.46 6 276867 54 79467461
Urinary tract infection fungal 14.35 10.46 18 276855 1035 79466480
Portal fibrosis 14.35 10.46 14 276859 607 79466908
Oligoarthritis 14.31 10.46 15 276858 709 79466806
Pancreatic abscess 14.31 10.46 7 276866 94 79467421
Japanese spotted fever 14.30 10.46 5 276868 26 79467489
Parapox virus infection 14.30 10.46 4 276869 8 79467507
Multiple fractures 14.28 10.46 5 276868 8021 79459494
Bursitis infective 14.24 10.46 20 276853 1284 79466231
Renal hypertension 14.23 10.46 9 276864 204 79467311
Incorrect dose administered 14.22 10.46 184 276689 76446 79391069
Ophthalmic herpes simplex 14.21 10.46 15 276858 715 79466800
Metastases to muscle 14.17 10.46 11 276862 349 79467166
Mycobacterium kansasii infection 14.12 10.46 11 276862 351 79467164
Viral uveitis 14.11 10.46 7 276866 97 79467418
Herpes simplex encephalitis 14.10 10.46 15 276858 721 79466794
Hypokinesia 14.10 10.46 28 276845 19032 79448483
Human herpes virus 6 serology positive 14.08 10.46 9 276864 208 79467307
Haemophilus infection 14.08 10.46 27 276846 2249 79465266
Gastrointestinal disorder 14.04 10.46 320 276553 121885 79345630
Ankylosing spondylitis 14.02 10.46 13 276860 12192 79455323
Gastroenteritis viral 14.01 10.46 42 276831 24789 79442726
Burkitt's leukaemia 14 10.46 3 276870 0 79467515
High grade B-cell lymphoma Burkitt-like lymphoma stage IV 14 10.46 3 276870 0 79467515
West Nile virus test positive 14 10.46 3 276870 0 79467515
Retroperitoneal effusion 14 10.46 3 276870 0 79467515
Renal vascular resistance increased 14 10.46 3 276870 0 79467515
Toxocariasis 14 10.46 3 276870 0 79467515
Microtia 14 10.46 3 276870 0 79467515
Pneumonia proteus 14 10.46 3 276870 0 79467515
Pulmonary sensitisation 14 10.46 3 276870 0 79467515
Oropharyngeal lymphoid hyperplasia 14 10.46 3 276870 0 79467515
Agranulocytosis 14.00 10.46 227 276646 44803 79422712
Biliary ischaemia 14.00 10.46 6 276867 58 79467457
B-lymphocyte abnormalities 13.99 10.46 5 276868 28 79467487
Hepatitis infectious mononucleosis 13.99 10.46 8 276865 150 79467365
ABO incompatibility 13.98 10.46 4 276869 9 79467506
Anorectal infection bacterial 13.98 10.46 4 276869 9 79467506
Crystal nephropathy 13.97 10.46 21 276852 1434 79466081
Spinal operation 13.97 10.46 5 276868 7912 79459603
Dyspnoea at rest 13.97 10.46 4 276869 7298 79460217
Intestinal perforation 13.95 10.46 106 276767 17320 79450195
Peritoneal dialysis 13.91 10.46 16 276857 840 79466675
Abdominal lymphadenopathy 13.89 10.46 20 276853 1314 79466201
Hypoproteinaemia 13.86 10.46 38 276835 4008 79463507
Subdural haematoma 13.85 10.46 59 276814 31375 79436140
Neurofibrosarcoma 13.82 10.46 9 276864 215 79467300
Arteriovenous fistula occlusion 13.80 10.46 13 276860 539 79466976
Transient acantholytic dermatosis 13.80 10.46 8 276865 154 79467361
Lemierre syndrome 13.80 10.46 8 276865 154 79467361
Coagulation test abnormal 13.76 10.46 20 276853 1325 79466190
Biopsy liver abnormal 13.75 10.46 12 276861 450 79467065
Asteatosis 13.74 10.46 7 276866 103 79467412
Leukaemia in remission 13.69 10.46 4 276869 10 79467505
Carotid artery perforation 13.69 10.46 4 276869 10 79467505
Rectal prolapse 13.67 10.46 26 276847 2152 79465363
Hepatorenal syndrome 13.67 10.46 39 276834 4210 79463305
Ocular hyperaemia 13.66 10.46 51 276822 28155 79439360
Blindness cortical 13.65 10.46 17 276856 970 79466545
Lung squamous cell carcinoma stage IV 13.65 10.46 6 276867 62 79467453
Acinetobacter sepsis 13.65 10.46 6 276867 62 79467453
Aortic rupture 13.63 10.46 9 276864 220 79467295
Diabetic nephropathy 13.60 10.46 31 276842 2916 79464599
Norovirus test positive 13.59 10.46 14 276859 648 79466867
Cardiac index increased 13.57 10.46 5 276868 31 79467484
Tracheobronchitis 13.56 10.46 25 276848 2021 79465494
Metastases to abdominal cavity 13.56 10.46 14 276859 650 79466865
Blood urine present 13.53 10.46 34 276839 21263 79446252
Gastroenteritis eosinophilic 13.51 10.46 10 276863 295 79467220
T-lymphocyte count decreased 13.51 10.46 13 276860 554 79466961
Acute hepatic failure 13.50 10.46 162 276711 29951 79437564
Intestinal metastasis 13.50 10.46 11 276862 375 79467140
Retching 13.49 10.46 25 276848 17442 79450073
Blood pressure ambulatory increased 13.48 10.46 6 276867 64 79467451
Plasma cell myeloma 13.47 10.46 119 276754 53140 79414375
Tongue oedema 13.43 10.46 4 276869 7113 79460402
Blood 25-hydroxycholecalciferol decreased 13.42 10.46 11 276862 378 79467137
Oesophageal tuberculosis 13.42 10.46 4 276869 11 79467504
Postoperative hypertension 13.42 10.46 4 276869 11 79467504
Picornavirus infection 13.42 10.46 4 276869 11 79467504
Breast cancer female 13.41 10.46 12 276861 11449 79456066
Dry throat 13.37 10.46 5 276868 7701 79459814
Metapneumovirus infection 13.37 10.46 23 276850 1761 79465754
Anosmia 13.36 10.46 7 276866 8837 79458678
Marrow hyperplasia 13.35 10.46 22 276851 1626 79465889
Splenic infection fungal 13.33 10.46 7 276866 110 79467405
Cholecystitis chronic 13.33 10.46 9 276864 9897 79457618
Brown-Sequard syndrome 13.32 10.46 6 276867 66 79467449
Breast pain 13.31 10.46 6 276867 8259 79459256
Hepatobiliary infection 13.31 10.46 5 276868 33 79467482
Tooth loss 13.31 10.46 4 276869 7071 79460444
Pelvic venous thrombosis 13.28 10.46 26 276847 2199 79465316
Renal phospholipidosis 13.28 10.46 7 276866 111 79467404
Eructation 13.28 10.46 11 276862 10898 79456617
Neisseria infection 13.27 10.46 8 276865 166 79467349
Blood calcium increased 13.27 10.46 10 276863 10390 79457125
Resting tremor 13.27 10.46 21 276852 1500 79466015
Myasthenia gravis 13.27 10.46 10 276863 10389 79457126
Rebound effect 13.26 10.46 55 276818 7171 79460344
Otitis media 13.25 10.46 49 276824 6057 79461458
Gastrointestinal necrosis 13.22 10.46 46 276827 5519 79461996
Non-cirrhotic portal hypertension 13.21 10.46 12 276861 475 79467040
Renal infarct 13.19 10.46 29 276844 2662 79464853
Bronchopneumopathy 13.18 10.46 15 276858 778 79466737
Large intestine infection 13.17 10.46 32 276841 3137 79464378
Anti-interferon antibody positive 13.16 10.46 4 276869 12 79467503
Drug level 13.16 10.46 4 276869 12 79467503
Argentine haemorrhagic fever 13.16 10.46 4 276869 12 79467503
Dermatitis papillaris capillitii 13.16 10.46 4 276869 12 79467503
Sebaceous hyperplasia 13.08 10.46 6 276867 69 79467446
Coinfection 13.08 10.46 6 276867 69 79467446
Disorientation 13.07 10.46 147 276726 62629 79404886
Reticulocyte count decreased 13.06 10.46 16 276857 898 79466617
Blood lactic acid increased 13.02 10.46 15 276858 12729 79454786
Radiculitis brachial 13.01 10.46 6 276867 70 79467445
B-lymphocyte count decreased 13.00 10.46 20 276853 1394 79466121
Decreased activity 12.96 10.46 7 276866 8687 79458828
Organ failure 12.96 10.46 37 276836 3996 79463519
Hepatic infection 12.95 10.46 17 276856 1023 79466492
Pharyngeal abscess 12.95 10.46 14 276859 686 79466829
Narrow anterior chamber angle 12.94 10.46 8 276865 174 79467341
Balamuthia infection 12.94 10.46 5 276868 36 79467479
Iliac artery disease 12.92 10.46 4 276869 13 79467502
Herpes sepsis 12.92 10.46 4 276869 13 79467502
Bronchopulmonary disease 12.92 10.46 4 276869 13 79467502
Parotid abscess 12.92 10.46 4 276869 13 79467502
Initial insomnia 12.91 10.46 4 276869 6934 79460581
Immunodeficiency 12.88 10.46 36 276837 21732 79445783
Scleroderma renal crisis 12.87 10.46 13 276860 588 79466927
Joint effusion 12.87 10.46 27 276846 17987 79449528
Skin weeping 12.86 10.46 17 276856 1030 79466485
Pulmonary sepsis 12.86 10.46 35 276838 3677 79463838
Food interaction 12.83 10.46 22 276851 1680 79465835
Spinal pain 12.83 10.46 21 276852 15371 79452144
Plasmacytoma 12.81 10.46 39 276834 4364 79463151
Multi-organ disorder 12.81 10.46 28 276845 2560 79464955
Necrotising herpetic retinopathy 12.79 10.46 7 276866 120 79467395
Hypernatraemia 12.73 10.46 19 276854 14432 79453083
Rhinocerebral mucormycosis 12.72 10.46 17 276856 1041 79466474
Small intestine gangrene 12.70 10.46 4 276869 14 79467501
Tonsillar neoplasm 12.70 10.46 4 276869 14 79467501
Osteomyelitis 12.69 10.46 172 276701 32693 79434822
Oral lichen planus 12.69 10.46 15 276858 811 79466704
Post streptococcal glomerulonephritis 12.59 10.46 7 276866 124 79467391
Mucosal necrosis 12.59 10.46 7 276866 124 79467391
Ligament sprain 12.55 10.46 17 276856 13447 79454068
Infusion site extravasation 12.54 10.46 10 276863 10098 79457417
Leiomyoma 12.50 10.46 10 276863 332 79467183
Thymus enlargement 12.49 10.46 7 276866 126 79467389
Oesophageal squamous cell carcinoma stage IV 12.49 10.46 4 276869 15 79467500
Metastases to skin 12.48 10.46 22 276851 1717 79465798
Pancreatic pseudoaneurysm 12.44 10.46 6 276867 78 79467437
Leukaemic infiltration extramedullary 12.43 10.46 8 276865 187 79467328
Tooth fracture 12.41 10.46 13 276860 11517 79455998
Glomerular filtration rate decreased 12.41 10.46 127 276746 22575 79444940
Bronchoalveolar lavage abnormal 12.38 10.46 9 276864 258 79467257
Right ventricular failure 12.38 10.46 41 276832 23456 79444059
Metastases to abdominal wall 12.36 10.46 8 276865 189 79467326
Malnutrition 12.35 10.46 126 276747 22376 79445139
Gingival pain 12.34 10.46 8 276865 8990 79458525
Enterocolitis haemorrhagic 12.33 10.46 25 276848 2169 79465346
Heart transplant 12.31 10.46 20 276853 1461 79466054
Renal artery perforation 12.28 10.46 4 276869 16 79467499
Sarcomatoid carcinoma 12.28 10.46 5 276868 42 79467473
VIth nerve paralysis 12.25 10.46 21 276852 1603 79465912
Septal panniculitis 12.25 10.46 7 276866 131 79467384
Purulent pericarditis 12.24 10.46 6 276867 81 79467434
Hepatic atrophy 12.22 10.46 11 276862 430 79467085
Hypergammaglobulinaemia 12.20 10.46 14 276859 733 79466782
Infusion site erythema 12.20 10.46 9 276864 9451 79458064
Venous haemorrhage 12.19 10.46 10 276863 344 79467171
Mean cell haemoglobin concentration 12.17 10.46 5 276868 43 79467472
Cardiac tamponade 12.16 10.46 64 276809 9212 79458303
Embolic stroke 12.11 10.46 6 276867 7820 79459695
Hypervolaemia 12.10 10.46 212 276661 42478 79425037
Artery dissection 12.06 10.46 9 276864 269 79467246
Eyelid oedema 12.05 10.46 18 276855 13669 79453846
Segmented hyalinising vasculitis 12.04 10.46 6 276867 84 79467431
Fanconi syndrome 12.04 10.46 29 276844 2827 79464688
Nerve injury 12.02 10.46 9 276864 9383 79458132
Cerebrovascular insufficiency 12.02 10.46 7 276866 136 79467379
Malignant melanoma 11.98 10.46 90 276783 14651 79452864
Actinomycosis 11.98 10.46 17 276856 1102 79466413
Renal tuberculosis 11.98 10.46 5 276868 45 79467470
Systemic bartonellosis 11.93 10.46 3 276870 3 79467512
Panel-reactive antibody increased 11.93 10.46 3 276870 3 79467512
Multivisceral transplantation 11.93 10.46 3 276870 3 79467512
Neurological infection 11.93 10.46 3 276870 3 79467512
Visual agnosia 11.93 10.46 3 276870 3 79467512
Brachyspira infection 11.93 10.46 3 276870 3 79467512
Sialocele 11.93 10.46 3 276870 3 79467512
Epstein-Barr virus test negative 11.93 10.46 3 276870 3 79467512
Removal of transplanted organ 11.93 10.46 3 276870 3 79467512
Germ cell cancer metastatic 11.93 10.46 3 276870 3 79467512
Eccrine carcinoma 11.93 10.46 3 276870 3 79467512
Exserohilum infection 11.93 10.46 3 276870 3 79467512
Aeromonas test positive 11.93 10.46 3 276870 3 79467512
Endocrine pancreatic disorder 11.93 10.46 3 276870 3 79467512
Iliac artery rupture 11.93 10.46 3 276870 3 79467512
Renal transplant torsion 11.93 10.46 3 276870 3 79467512
Thrombasthenia 11.93 10.46 3 276870 3 79467512
Eosinophil count increased 11.92 10.46 26 276847 17079 79450436
Feeding disorder 11.92 10.46 24 276849 16230 79451285
Accident 11.91 10.46 8 276865 8823 79458692
Culture positive 11.90 10.46 17 276856 1109 79466406
Varicella virus test positive 11.89 10.46 8 276865 202 79467313
Seroconversion test positive 11.88 10.46 5 276868 46 79467469
Intentional dose omission 11.88 10.46 8 276865 8809 79458706
Brain death 11.86 10.46 45 276828 5632 79461883
Hepatic artery occlusion 11.86 10.46 6 276867 87 79467428
Pseudopolyp 11.84 10.46 11 276862 448 79467067
Therapeutic response unexpected 11.79 10.46 33 276840 19913 79447602
Renal cyst infection 11.79 10.46 8 276865 205 79467310
Infective aortitis 11.79 10.46 5 276868 47 79467468
Visual evoked potentials abnormal 11.79 10.46 5 276868 47 79467468
Laryngeal cancer 11.78 10.46 14 276859 761 79466754
Atrophy 11.77 10.46 24 276849 2090 79465425
Clostridium test positive 11.75 10.46 49 276824 6405 79461110
Melaena 11.74 10.46 145 276728 60745 79406770
Herpes zoster oticus 11.70 10.46 11 276862 455 79467060
Urine abnormality 11.70 10.46 7 276866 8212 79459303
Lymphangitis 11.68 10.46 19 276854 1389 79466126
Tendon rupture 11.62 10.46 15 276858 12111 79455404
Knee operation 11.62 10.46 3 276870 5863 79461652
Hypocalcaemia 11.57 10.46 114 276759 49810 79417705
Deafness 11.57 10.46 36 276837 21001 79446514
Ureteritis 11.56 10.46 6 276867 92 79467423
Glomerulonephritis acute 11.53 10.46 9 276864 288 79467227
Cutaneous sporotrichosis 11.52 10.46 5 276868 50 79467465
Type 3 diabetes mellitus 11.52 10.46 5 276868 50 79467465
Schistocytosis 11.52 10.46 5 276868 50 79467465
Polyneuropathy 11.48 10.46 44 276829 24107 79443408
Wound abscess 11.48 10.46 9 276864 290 79467225
Hookworm infection 11.47 10.46 3 276870 4 79467511
X-ray abnormal 11.47 10.46 3 276870 5810 79461705
Haemarthrosis 11.46 10.46 3 276870 5809 79461706
Hepatic infarction 11.46 10.46 15 276858 900 79466615
Cord blood transplant therapy 11.43 10.46 5 276868 51 79467464
Splenic neoplasm malignancy unspecified 11.43 10.46 5 276868 51 79467464
Vascular graft thrombosis 11.42 10.46 8 276865 216 79467299
T-lymphocyte count abnormal 11.41 10.46 4 276869 21 79467494
Hypoplastic anaemia 11.41 10.46 4 276869 21 79467494
Nephrogenic systemic fibrosis 11.39 10.46 47 276826 6113 79461402
Colon dysplasia 11.36 10.46 8 276865 218 79467297
Colitis erosive 11.33 10.46 7 276866 152 79467363
Gastrointestinal haemorrhage 11.33 10.46 409 276464 147310 79320205
Renal amyloidosis 11.33 10.46 7 276866 152 79467363
Chronic myeloid leukaemia recurrent 11.32 10.46 9 276864 296 79467219
Bundle branch block left 11.29 10.46 14 276859 11499 79456016
Sensory disturbance 11.28 10.46 22 276851 15055 79452460
Meningitis enterococcal 11.28 10.46 6 276867 97 79467418
Leishmaniasis 11.26 10.46 10 276863 384 79467131
Tonsillar exudate 11.26 10.46 4 276869 22 79467493
Herpes zoster 11.23 10.46 412 276461 92671 79374844
Pyonephrosis 11.22 10.46 6 276867 98 79467417
Portal vein flow decreased 11.18 10.46 5 276868 54 79467461
Autoimmune enteropathy 11.18 10.46 5 276868 54 79467461
Muscle neoplasm 11.18 10.46 5 276868 54 79467461
Ichthyosis 11.17 10.46 7 276866 156 79467359
Osteomyelitis chronic 11.17 10.46 13 276860 691 79466824
Scoliosis 11.14 10.46 6 276867 7458 79460057
Inappropriate antidiuretic hormone secretion 11.12 10.46 140 276733 26173 79441342
Budd-Chiari syndrome 11.12 10.46 6 276867 100 79467415
Small cell lung cancer recurrent 11.11 10.46 4 276869 23 79467492
Large cell lung cancer 11.11 10.46 4 276869 23 79467492
Meningitis listeria 11.09 10.46 16 276857 1053 79466462
Skin hypertrophy 11.08 10.46 40 276833 4888 79462627
Oropharyngeal candidiasis 11.06 10.46 21 276852 1736 79465779
Cerebral mass effect 11.05 10.46 22 276851 1884 79465631
Intraocular pressure increased 11.05 10.46 62 276811 9143 79458372
Lentigo 11.03 10.46 11 276862 490 79467025
Infective keratitis 11.02 10.46 5 276868 56 79467459
Pericardial fibrosis 11.02 10.46 7 276866 160 79467355
Tendon pain 11.01 10.46 3 276870 5655 79461860
Pregnancy 10.98 10.46 142 276731 26709 79440806
Quadriplegia 10.96 10.46 31 276842 3329 79464186
Serum ferritin increased 10.95 10.46 65 276808 9782 79457733
Hepatic echinococciasis 10.94 10.46 5 276868 57 79467458
Herpes simplex meningitis 10.94 10.46 5 276868 57 79467458
Myeloma cast nephropathy 10.94 10.46 7 276866 162 79467353
Corynebacterium sepsis 10.87 10.46 5 276868 58 79467457
Keratitis fungal 10.84 10.46 9 276864 315 79467200
Diabetic neuropathy 10.84 10.46 4 276869 6212 79461303
Hepatitis C RNA 10.83 10.46 4 276869 25 79467490
Creatinine renal clearance decreased 10.82 10.46 32 276841 18970 79448545
Dystonia 10.82 10.46 38 276835 21361 79446154
Electrocardiogram ST segment elevation 10.81 10.46 8 276865 8389 79459126
Inflammatory myofibroblastic tumour 10.79 10.46 7 276866 166 79467349
Vasoconstriction 10.79 10.46 13 276860 717 79466798
Eye pruritus 10.76 10.46 36 276837 20534 79446981
Red cell distribution width increased 10.76 10.46 23 276850 15219 79452296
Lipids abnormal 10.76 10.46 12 276861 609 79466906
Glaucoma 10.74 10.46 34 276839 19727 79447788
Wound infection 10.73 10.46 129 276744 23862 79443653
Oesophagogastroscopy normal 10.72 10.46 3 276870 6 79467509
Actinic cheilitis 10.72 10.46 3 276870 6 79467509
Anaplastic large cell lymphoma T- and null-cell types stage III 10.72 10.46 3 276870 6 79467509
Chromophobe renal cell carcinoma 10.72 10.46 3 276870 6 79467509
Erdheim-Chester disease 10.72 10.46 3 276870 6 79467509
Biopsy kidney 10.72 10.46 7 276866 168 79467347
Viral myositis 10.72 10.46 5 276868 60 79467455
Corneal graft rejection 10.72 10.46 5 276868 60 79467455
Endotoxic shock 10.70 10.46 4 276869 26 79467489
Extradural abscess 10.69 10.46 19 276854 1493 79466022
Paronychia 10.63 10.46 7 276866 7801 79459714
Endocarditis candida 10.61 10.46 6 276867 110 79467405
Aortic dilatation 10.60 10.46 21 276852 1791 79465724
Adverse reaction 10.60 10.46 10 276863 9304 79458211
Hirsutism 10.60 10.46 18 276855 1364 79466151
Hepatic neoplasm 10.59 10.46 31 276842 3395 79464120
Splenic necrosis 10.57 10.46 7 276866 172 79467343
Premature baby 10.55 10.46 33 276840 3747 79463768
Retinal scar 10.55 10.46 10 276863 418 79467097
Acidosis 10.54 10.46 110 276763 19652 79447863
Symptom masked 10.52 10.46 18 276855 1372 79466143
Metastases to central nervous system 10.51 10.46 26 276847 16349 79451166
Ureteric dilatation 10.50 10.46 7 276866 174 79467341
Hypoventilation 10.50 10.46 6 276867 7218 79460297
Duodenitis 10.46 10.46 55 276818 7912 79459603

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D11AH01 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Agents for dermatitis, excluding corticosteroids
ATC L04AD02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Calcineurin inhibitors
FDA EPC N0000175457 Calcineurin Inhibitor Immunosuppressant
FDA MoA N0000175458 Calcineurin Inhibitors
CHEBI has role CHEBI:35705 immunosuppressive agents
MeSH PA D065095 Calcineurin Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Atopic dermatitis indication 24079001 DOID:3310
Transplanted organ rejection indication 213148006
Liver transplant rejection indication 235911006
Renal transplant rejection indication 236570004
Prevention of Cardiac Transplant Rejection indication
Prevention of Transplant Rejection indication
Prevention of Liver Transplant Rejection indication
Intractable Eczema indication
Prevention of Kidney Transplant Rejection indication
Prevention of Lung Transplant Rejection off-label use
Delirium contraindication 2776000
Herpes zoster contraindication 4740000 DOID:8536
Hyperkalemia contraindication 14140009
Progressive multifocal leukoencephalopathy contraindication 22255007 DOID:643
Constitutional aplastic anemia contraindication 28975000 DOID:1342
Lymphadenopathy contraindication 30746006
Torsades de pointes contraindication 31722008
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Mental handicap contraindication 47437004
Chronic heart failure contraindication 48447003
Left ventricular hypertrophy contraindication 55827005
Hepatic failure contraindication 59927004
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Herpes simplex contraindication 88594005 DOID:8566
Kidney disease contraindication 90708001 DOID:557
Prolonged QT interval contraindication 111975006
Malignant lymphoma contraindication 118600007 DOID:0060058
Seizure disorder contraindication 128613002
Eczema herpeticum contraindication 186535001 DOID:9123
Toxic nephropathy contraindication 236514003
Post-transplant lymphoproliferative disorder contraindication 254290004
Infectious mononucleosis contraindication 271558008 DOID:8568
Netherton's syndrome contraindication 312514006
Coma contraindication 371632003
Primary malignant neoplasm contraindication 372087000
Neuropathy contraindication 386033004 DOID:870
Breastfeeding (mother) contraindication 413712001
Congenital long QT syndrome contraindication 442917000
Posterior reversible encephalopathy syndrome contraindication 450886002
Tacrolimus Toxicity contraindication
Tremors contraindication
BK Polyomavirus Reactivation Nephropathy contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.4 acidic
pKa2 13.12 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10548880 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10548880 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8486993 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8586084 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8623411 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8889185 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8889186 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 9161907 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10548880 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10548880 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8486993 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8586084 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8623411 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8889185 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8889186 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 9161907 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10548880 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10548880 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8486993 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8586084 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8623411 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8889185 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8889186 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 9161907 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10864199 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10864199 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 11110081 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 11123331 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10864199 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10864199 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 11110081 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 11123331 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10864199 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10864199 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 11110081 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 11123331 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8664239 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8664239 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8664239 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8685998 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8685998 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8685998 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8664239 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8664239 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8664239 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8685998 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8685998 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8685998 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8664239 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8664239 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8664239 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8685998 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8685998 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8685998 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 0.5MG BASE PROGRAF ASTELLAS N050708 Aug. 24, 1998 RX CAPSULE ORAL May 24, 2025 PROPHYLAXIS OF ORGAN REJECTION IN PEDIATRIC PATIENTS RECEIVING ALLOGENEIC KIDNEY OR HEART TRANSPLANTS, IN COMBINATION WITH OTHER IMMUNOSUPPRESSANTS
EQ 1MG BASE PROGRAF ASTELLAS N050708 April 8, 1994 RX CAPSULE ORAL May 24, 2025 PROPHYLAXIS OF ORGAN REJECTION IN PEDIATRIC PATIENTS RECEIVING ALLOGENEIC KIDNEY OR HEART TRANSPLANTS, IN COMBINATION WITH OTHER IMMUNOSUPPRESSANTS
EQ 5MG BASE PROGRAF ASTELLAS N050708 April 8, 1994 RX CAPSULE ORAL May 24, 2025 PROPHYLAXIS OF ORGAN REJECTION IN PEDIATRIC PATIENTS RECEIVING ALLOGENEIC KIDNEY OR HEART TRANSPLANTS, IN COMBINATION WITH OTHER IMMUNOSUPPRESSANTS
EQ 5MG BASE/ML PROGRAF ASTELLAS N050709 April 8, 1994 RX INJECTABLE INJECTION May 24, 2025 PROPHYLAXIS OF ORGAN REJECTION IN PEDIATRIC PATIENTS RECEIVING ALLOGENEIC KIDNEY OR HEART TRANSPLANTS, IN COMBINATION WITH OTHER IMMUNOSUPPRESSANTS
EQ 0.5MG BASE ASTAGRAF XL ASTELLAS N204096 July 19, 2013 RX CAPSULE, EXTENDED RELEASE ORAL May 24, 2025 FDA HAS NOT RECOGNIZED ORPHAN-DRUG EXCLUSIVITY (ODE) FOR THIS DRUG, BUT IT CONTAINS THE SAME ACTIVE MOIETY OR MOIETIES AS ANOTHER DRUG(S) THAT WAS ELIGIBLE FOR ODE, AND ALSO SHARES ODE-PROTECTED USE(S) OR INDICATION(S) WITH THAT DRUG(S). AN APPLICATION SEEKING APPROVAL FOR THE SAME ACTIVE MOIETY OR MOIETIES, INCLUDING AN ANDA THAT CITES THIS NDA AS ITS BASIS OF SUBMISSION, MAY NOT BE APPROVED FOR SUCH ODE-PROTECTED USE(S) AND INDICATION(S)
EQ 1MG BASE ASTAGRAF XL ASTELLAS N204096 July 19, 2013 RX CAPSULE, EXTENDED RELEASE ORAL May 24, 2025 FDA HAS NOT RECOGNIZED ORPHAN-DRUG EXCLUSIVITY (ODE) FOR THIS DRUG, BUT IT CONTAINS THE SAME ACTIVE MOIETY OR MOIETIES AS ANOTHER DRUG(S) THAT WAS ELIGIBLE FOR ODE, AND ALSO SHARES ODE-PROTECTED USE(S) OR INDICATION(S) WITH THAT DRUG(S). AN APPLICATION SEEKING APPROVAL FOR THE SAME ACTIVE MOIETY OR MOIETIES, INCLUDING AN ANDA THAT CITES THIS NDA AS ITS BASIS OF SUBMISSION, MAY NOT BE APPROVED FOR SUCH ODE-PROTECTED USE(S) AND INDICATION(S)
EQ 5MG BASE ASTAGRAF XL ASTELLAS N204096 July 19, 2013 RX CAPSULE, EXTENDED RELEASE ORAL May 24, 2025 FDA HAS NOT RECOGNIZED ORPHAN-DRUG EXCLUSIVITY (ODE) FOR THIS DRUG, BUT IT CONTAINS THE SAME ACTIVE MOIETY OR MOIETIES AS ANOTHER DRUG(S) THAT WAS ELIGIBLE FOR ODE, AND ALSO SHARES ODE-PROTECTED USE(S) OR INDICATION(S) WITH THAT DRUG(S). AN APPLICATION SEEKING APPROVAL FOR THE SAME ACTIVE MOIETY OR MOIETIES, INCLUDING AN ANDA THAT CITES THIS NDA AS ITS BASIS OF SUBMISSION, MAY NOT BE APPROVED FOR SUCH ODE-PROTECTED USE(S) AND INDICATION(S)
EQ 0.2MG BASE/PACKET PROGRAF ASTELLAS N210115 May 24, 2018 RX FOR SUSPENSION ORAL May 24, 2025 PROPHYLAXIS OF ORGAN REJECTION IN PEDIATRIC PATIENTS RECEIVING ALLOGENEIC KIDNEY TRANSPLANT, LIVER TRANSPLANTS, AND HEART TRANSPLANT, IN COMBINATION WITH OTHER IMMUNOSUPPRESSANTS
EQ 1MG BASE/PACKET PROGRAF ASTELLAS N210115 May 24, 2018 RX FOR SUSPENSION ORAL May 24, 2025 PROPHYLAXIS OF ORGAN REJECTION IN PEDIATRIC PATIENTS RECEIVING ALLOGENEIC KIDNEY TRANSPLANT, LIVER TRANSPLANTS, AND HEART TRANSPLANT, IN COMBINATION WITH OTHER IMMUNOSUPPRESSANTS
EQ 0.5MG BASE PROGRAF ASTELLAS N050708 Aug. 24, 1998 RX CAPSULE ORAL July 16, 2028 FOR PROPHYLAXIS OF ORGAN REJECTION IN ADULT AND PEDIATRIC PATIENTS RECEIVING ALLOGENEIC LUNG TRANSPLANT
EQ 1MG BASE PROGRAF ASTELLAS N050708 April 8, 1994 RX CAPSULE ORAL July 16, 2028 FOR PROPHYLAXIS OF ORGAN REJECTION IN ADULT AND PEDIATRIC PATIENTS RECEIVING ALLOGENEIC LUNG TRANSPLANT
EQ 5MG BASE PROGRAF ASTELLAS N050708 April 8, 1994 RX CAPSULE ORAL July 16, 2028 FOR PROPHYLAXIS OF ORGAN REJECTION IN ADULT AND PEDIATRIC PATIENTS RECEIVING ALLOGENEIC LUNG TRANSPLANT
EQ 5MG BASE/ML PROGRAF ASTELLAS N050709 April 8, 1994 RX INJECTABLE INJECTION July 16, 2028 FOR PROPHYLAXIS OF ORGAN REJECTION IN ADULT AND PEDIATRIC PATIENTS RECEIVING ALLOGENEIC LUNG TRANSPLANT
EQ 0.2MG BASE/PACKET PROGRAF ASTELLAS N210115 May 24, 2018 RX FOR SUSPENSION ORAL July 16, 2028 FOR PROPHYLAXIS OF ORGAN REJECTION IN ADULT AND PEDIATRIC PATIENTS RECEIVING ALLOGENEIC LUNG TRANSPLANT
EQ 1MG BASE/PACKET PROGRAF ASTELLAS N210115 May 24, 2018 RX FOR SUSPENSION ORAL July 16, 2028 FOR PROPHYLAXIS OF ORGAN REJECTION IN ADULT AND PEDIATRIC PATIENTS RECEIVING ALLOGENEIC LUNG TRANSPLANT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Peptidyl-prolyl cis-trans isomerase FKBP1A Enzyme INHIBITOR Kd 9.40 WOMBAT-PK CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6 WOMBAT-PK
Cytochrome P450 3A4 Enzyme IC50 6 DRUG MATRIX
Interleukin-5 Cytokine IC50 10.22 WOMBAT-PK
Interferon gamma Cytokine IC50 10.22 WOMBAT-PK
ATP-binding cassette sub-family G member 2 Transporter IC50 5.48 CHEMBL
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform Enzyme Ki 7.46 WOMBAT-PK
Serine/threonine-protein kinase mTOR Kinase IC50 9.02 CHEMBL
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Enzyme Kd 7.70 CHEMBL
Peptidyl-prolyl cis-trans isomerase FKBP1B Enzyme Kd 9.40 CHEMBL
Transient receptor potential cation channel subfamily M member 8 Ion channel ACTIVATOR EC50 4.85 IUPHAR
Peptidyl-prolyl cis-trans isomerase FKBP5 Enzyme Ki 7.10 CHEMBL
Splicing factor 3B subunit 3 Nuclear other IC50 7.96 CHEMBL
Interleukin-2 Cytokine IC50 9.72 WOMBAT-PK
Peptidyl-prolyl cis-trans isomerase FKBP10 Enzyme IC50 9.02 WOMBAT-PK

External reference:

IDSource
4020868 VUID
N0000148372 NUI
D00107 KEGG_DRUG
4020868 VANDF
C0085149 UMLSCUI
CHEBI:61049 CHEBI
CHEMBL269732 ChEMBL_ID
CHEMBL3989887 ChEMBL_ID
D016559 MESH_DESCRIPTOR_UI
DB00864 DRUGBANK_ID
6784 IUPHAR_LIGAND_ID
WM0HAQ4WNM UNII
445643 PUBCHEM_CID
235991 RXNORM
133309 MMSL
5539 MMSL
66434 MMSL
d03752 MMSL
004446 NDDF
004447 NDDF
109129008 SNOMEDCT_US
1269093001 SNOMEDCT_US
386975001 SNOMEDCT_US
6878 INN_ID
109581-93-3 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0093-3428 OINTMENT 0.30 mg TOPICAL ANDA 26 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0093-3429 OINTMENT 1 mg TOPICAL ANDA 26 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0168-0416 OINTMENT 1 mg TOPICAL ANDA 26 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0168-0417 OINTMENT 0.30 mg TOPICAL ANDA 26 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0378-2045 CAPSULE 0.50 mg ORAL ANDA 30 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0378-2045 CAPSULE 0.50 mg ORAL ANDA 30 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0378-2045 CAPSULE 0.50 mg ORAL ANDA 30 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0378-2046 CAPSULE 1 mg ORAL ANDA 30 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0378-2046 CAPSULE 1 mg ORAL ANDA 30 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0378-2046 CAPSULE 1 mg ORAL ANDA 30 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0378-2047 CAPSULE 5 mg ORAL ANDA 30 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0378-2047 CAPSULE 5 mg ORAL ANDA 30 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0378-2047 CAPSULE 5 mg ORAL ANDA 30 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-0607 CAPSULE, GELATIN COATED 0.50 mg ORAL NDA 30 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-0607 CAPSULE, GELATIN COATED 0.50 mg ORAL NDA 30 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-0607 CAPSULE, GELATIN COATED 0.50 mg ORAL NDA 30 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-0617 CAPSULE, GELATIN COATED 1 mg ORAL NDA 30 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-0617 CAPSULE, GELATIN COATED 1 mg ORAL NDA 30 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-0617 CAPSULE, GELATIN COATED 1 mg ORAL NDA 30 sections
ASTAGRAF XL HUMAN PRESCRIPTION DRUG LABEL 1 0469-0647 CAPSULE, COATED, EXTENDED RELEASE 0.50 mg ORAL NDA 27 sections
ASTAGRAF XL HUMAN PRESCRIPTION DRUG LABEL 1 0469-0647 CAPSULE, COATED, EXTENDED RELEASE 0.50 mg ORAL NDA 27 sections
ASTAGRAF XL HUMAN PRESCRIPTION DRUG LABEL 1 0469-0647 CAPSULE, COATED, EXTENDED RELEASE 0.50 mg ORAL NDA 27 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-0657 CAPSULE, GELATIN COATED 5 mg ORAL NDA 30 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-0657 CAPSULE, GELATIN COATED 5 mg ORAL NDA 30 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-0657 CAPSULE, GELATIN COATED 5 mg ORAL NDA 30 sections
ASTAGRAF XL HUMAN PRESCRIPTION DRUG LABEL 1 0469-0677 CAPSULE, COATED, EXTENDED RELEASE 1 mg ORAL NDA 27 sections
ASTAGRAF XL HUMAN PRESCRIPTION DRUG LABEL 1 0469-0677 CAPSULE, COATED, EXTENDED RELEASE 1 mg ORAL NDA 27 sections
ASTAGRAF XL HUMAN PRESCRIPTION DRUG LABEL 1 0469-0677 CAPSULE, COATED, EXTENDED RELEASE 1 mg ORAL NDA 27 sections
ASTAGRAF XL HUMAN PRESCRIPTION DRUG LABEL 1 0469-0687 CAPSULE, COATED, EXTENDED RELEASE 5 mg ORAL NDA 27 sections
ASTAGRAF XL HUMAN PRESCRIPTION DRUG LABEL 1 0469-0687 CAPSULE, COATED, EXTENDED RELEASE 5 mg ORAL NDA 27 sections