tacrolimus Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
immunosuppressants, rapamycin derivatives 2552 104987-11-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • FK-506
  • tacrolimus hydrate
  • tacrolimus
  • fujimycin
  • tsukubaenolide
  • anhydrous tacrolimus
  • tacrolimus anhydrous
  • modigraf
  • FR900506
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
  • Molecular weight: 804.03
  • Formula: C44H69NO12
  • CLOGP: 5.78
  • LIPINSKI: 3
  • HAC: 13
  • HDO: 3
  • TPSA: 178.36
  • ALOGS: -5.30
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
5 mg O
5 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.24 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 25 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 26 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 8, 1994 FDA ASTELLAS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Transplant rejection 3713.91 10.58 1231 109215 8365 46567251
Cytomegalovirus infection 2182.80 10.58 996 109450 17148 46558468
Post transplant lymphoproliferative disorder 1735.56 10.58 555 109891 3301 46572315
Transplant dysfunction 1661.19 10.58 563 109883 4119 46571497
Thrombotic microangiopathy 1649.25 10.58 651 109795 7655 46567961
Kidney transplant rejection 1258.58 10.58 443 110003 3675 46571941
Immunosuppressant drug level increased 1141.99 10.58 389 110057 2893 46572723
Product use in unapproved indication 990.18 10.58 1142 109304 89131 46486485
Liver transplant rejection 837.58 10.58 250 110196 1133 46574483
Graft versus host disease 824.36 10.58 372 110074 6216 46569400
Epstein-Barr virus infection 823.36 10.58 375 110071 6409 46569207
Cytomegalovirus viraemia 815.87 10.58 330 110116 4148 46571468
Polyomavirus-associated nephropathy 814.94 10.58 249 110197 1241 46574375
BK virus infection 759.39 10.58 277 110169 2572 46573044
Complications of transplanted kidney 735.83 10.58 255 110191 2008 46573608
Ovarian cyst 698.63 10.58 428 110018 13659 46561957
Posterior reversible encephalopathy syndrome 660.31 10.58 424 110022 14717 46560899
Acute graft versus host disease 652.66 10.58 273 110173 3757 46571859
Acne 548.70 10.58 421 110025 19498 46556118
Fatigue 542.98 10.58 392 110054 608305 45967311
Renal impairment 523.63 10.58 756 109690 73616 46502000
Chronic graft versus host disease 500.45 10.58 202 110244 2523 46573093
Off label use 484.99 10.58 1976 108470 377865 46197751
Acute graft versus host disease in skin 459.48 10.58 195 110251 2787 46572829
Bronchopulmonary aspergillosis 424.19 10.58 248 110198 7248 46568368
Immunosuppressant drug level decreased 422.76 10.58 135 110311 797 46574819
COVID-19 422.71 10.58 351 110095 18224 46557392
Transplant failure 406.50 10.58 141 110305 1113 46574503
Multiple organ dysfunction syndrome 399.91 10.58 550 109896 51160 46524456
Aspergillus infection 397.95 10.58 231 110215 6659 46568957
Drug level increased 387.82 10.58 333 110113 18108 46557508
Pneumocystis jirovecii pneumonia 382.51 10.58 305 110141 14943 46560673
Drug hypersensitivity 375.51 10.58 63 110383 243762 46331854
Delayed graft function 336.69 10.58 115 110331 862 46574754
Nephropathy toxic 335.49 10.58 213 110233 7241 46568375
Fall 333.65 10.58 182 110264 328915 46246701
Completed suicide 315.41 10.58 6 110440 145914 46429702
Blood creatinine increased 313.56 10.58 610 109836 75793 46499823
Arthralgia 313.46 10.58 243 110203 364360 46211256
Nocardiosis 307.77 10.58 123 110323 1494 46574122
Dyspnoea 304.99 10.58 469 109977 515079 46060537
Dizziness 302.71 10.58 219 110227 340195 46235421
Chronic allograft nephropathy 301.29 10.58 96 110350 562 46575054
Premature delivery 294.72 10.58 310 110136 21759 46553857
Graft versus host disease in gastrointestinal tract 293.81 10.58 136 110310 2414 46573202
Escherichia infection 285.56 10.58 223 110223 10594 46565022
Klebsiella infection 281.60 10.58 183 110263 6479 46569137
Haemolytic uraemic syndrome 270.86 10.58 128 110318 2386 46573230
Sleep disorder due to general medical condition, insomnia type 269.19 10.58 163 110283 5086 46570530
Pain 267.69 10.58 449 109997 476499 46099117
Graft versus host disease in skin 265.76 10.58 124 110322 2243 46573373
Smooth muscle cell neoplasm 265.48 10.58 84 110362 479 46575137
Enterococcal infection 264.07 10.58 179 110267 6808 46568808
Nausea 261.88 10.58 800 109646 686654 45888962
Trichodysplasia spinulosa 261.71 10.58 78 110368 351 46575265
Renal transplant failure 260.48 10.58 86 110360 573 46575043
Haemophagocytic lymphohistiocytosis 260.15 10.58 190 110256 8152 46567464
Epstein-Barr virus associated lymphoproliferative disorder 259.11 10.58 106 110340 1373 46574243
Adenovirus infection 250.56 10.58 126 110320 2704 46572912
Cytomegalovirus infection reactivation 246.01 10.58 102 110344 1370 46574246
Mucormycosis 244.80 10.58 116 110330 2176 46573440
Joint swelling 244.51 10.58 48 110398 166025 46409591
Kidney fibrosis 242.41 10.58 100 110346 1325 46574291
Diffuse large B-cell lymphoma 240.95 10.58 159 110287 5779 46569837
Strongyloidiasis 237.57 10.58 86 110360 779 46574837
Leukopenia 236.96 10.58 509 109937 67834 46507782
Aplasia pure red cell 233.61 10.58 140 110306 4285 46571331
Post transplant distal limb syndrome 231.25 10.58 61 110385 155 46575461
Graft loss 230.18 10.58 69 110377 318 46575298
Exposure during pregnancy 229.46 10.58 668 109778 107544 46468072
Lung transplant rejection 228.33 10.58 81 110365 688 46574928
Phaeohyphomycosis 224.37 10.58 61 110385 181 46575435
Cytomegalovirus test positive 219.14 10.58 115 110331 2705 46572911
Drug interaction 219.14 10.58 1006 109440 202088 46373528
JC virus infection 214.71 10.58 96 110350 1566 46574050
Pain in extremity 211.32 10.58 181 110265 258499 46317117
Renal transplant 209.93 10.58 88 110358 1217 46574399
Acute graft versus host disease in intestine 209.73 10.58 95 110351 1600 46574016
Septic shock 209.73 10.58 439 110007 57454 46518162
Heart transplant rejection 206.81 10.58 67 110379 417 46575199
Acute kidney injury 205.95 10.58 1100 109346 234755 46340861
Lymphocele 203.13 10.58 76 110370 762 46574854
Focal segmental glomerulosclerosis 199.45 10.58 87 110359 1334 46574282
Viraemia 197.99 10.58 79 110367 955 46574661
Pseudomonas infection 196.62 10.58 172 110274 9586 46566030
Headache 189.28 10.58 546 109900 477806 46097810
Varicella zoster virus infection 183.36 10.58 96 110350 2247 46573369
Lymphoproliferative disorder 181.79 10.58 100 110346 2592 46573024
Parvovirus B19 infection 181.63 10.58 56 110390 289 46575327
Peripheral swelling 180.48 10.58 74 110372 157997 46417619
Malaise 179.80 10.58 318 110128 330914 46244702
Diabetes mellitus 178.25 10.58 377 110069 49688 46525928
Epstein-Barr viraemia 175.59 10.58 66 110380 671 46574945
Respiratory failure 175.34 10.58 558 109888 94258 46481358
Injection site pain 173.16 10.58 24 110422 107128 46468488
Human herpesvirus 6 infection 171.34 10.58 93 110353 2346 46573270
Sepsis 163.38 10.58 696 109750 135318 46440298
Anxiety 162.80 10.58 116 110330 181841 46393775
Renal tubular necrosis 157.83 10.58 159 110287 10600 46565016
Venoocclusive liver disease 153.75 10.58 106 110340 4145 46571471
Bacteraemia 152.71 10.58 178 110268 14001 46561615
Arthropathy 151.98 10.58 13 110433 84687 46490929
Asthenia 151.89 10.58 318 110128 310757 46264859
Rash 149.69 10.58 395 110051 356117 46219499
Histoplasmosis disseminated 148.76 10.58 66 110380 1056 46574560
Hypersensitivity 146.45 10.58 87 110359 150234 46425382
West Nile viral infection 145.97 10.58 49 110397 346 46575270
Pancreas transplant rejection 141.24 10.58 38 110408 107 46575509
Product dose omission issue 141.07 10.58 115 110331 168405 46407211
Chronic graft versus host disease in skin 138.44 10.58 53 110393 569 46575047
Polyomavirus viraemia 138.32 10.58 47 110399 346 46575270
Pyelonephritis 138.12 10.58 176 110270 15181 46560435
Back pain 137.65 10.58 177 110269 209862 46365754
Contraindicated product administered 136.25 10.58 15 110431 79932 46495684
Ureaplasma infection 134.76 10.58 48 110398 413 46575203
Somnolence 133.27 10.58 105 110341 156416 46419200
Pneumonia cytomegaloviral 132.88 10.58 73 110373 1887 46573729
Toxoplasmosis 132.09 10.58 65 110381 1329 46574287
Pancytopenia 131.11 10.58 471 109975 84587 46491029
Feeling abnormal 128.11 10.58 68 110378 124992 46450624
Complications of transplanted liver 128.01 10.58 45 110401 371 46575245
Cystitis haemorrhagic 127.23 10.58 88 110358 3459 46572157
Swelling 125.64 10.58 69 110377 124442 46451174
Constipation 125.52 10.58 136 110310 173961 46401655
Systemic candida 125.38 10.58 79 110367 2648 46572968
Depression 124.73 10.58 131 110315 169973 46405643
Syncope 124.63 10.58 46 110400 104757 46470859
Pathogen resistance 122.45 10.58 107 110339 5953 46569663
Cryptococcosis 122.30 10.58 53 110393 799 46574817
Systemic mycosis 121.09 10.58 54 110392 875 46574741
Renal tubular atrophy 120.81 10.58 46 110400 486 46575130
Nephrotic syndrome 118.21 10.58 96 110350 4825 46570791
Human polyomavirus infection 117.20 10.58 36 110410 183 46575433
Sinusitis 116.98 10.58 82 110364 129686 46445930
Cytomegalovirus colitis 115.92 10.58 64 110382 1671 46573945
Drug abuse 115.77 10.58 9 110437 63399 46512217
Drug level decreased 114.69 10.58 102 110344 5810 46569806
Hepatitis C 114.68 10.58 105 110341 6213 46569403
Infusion related reaction 114.46 10.58 48 110398 101160 46474456
Atypical haemolytic uraemic syndrome 113.72 10.58 43 110403 445 46575171
Proteinuria 112.99 10.58 166 110280 16387 46559229
Injection site erythema 112.68 10.58 20 110426 74407 46501209
Infection reactivation 112.52 10.58 49 110397 748 46574868
Abdominal discomfort 112.41 10.58 115 110331 151050 46424566
Tubulointerstitial nephritis 112.26 10.58 156 110290 14632 46560984
Obliterative bronchiolitis 111.84 10.58 63 110383 1712 46573904
Infective aneurysm 110.84 10.58 41 110405 397 46575219
Scedosporium infection 110.58 10.58 43 110403 483 46575133
Candida infection 110.55 10.58 193 110253 22047 46553569
Haemolytic anaemia 110.09 10.58 126 110320 9716 46565900
Progressive multifocal leukoencephalopathy 109.96 10.58 135 110311 11211 46564405
Cryptosporidiosis infection 109.79 10.58 36 110410 234 46575382
Renal failure 108.73 10.58 544 109902 113050 46462566
Chronic obstructive pulmonary disease 108.63 10.58 7 110439 57626 46517990
Chest discomfort 106.69 10.58 40 110406 90229 46485387
Cytomegalovirus enteritis 106.28 10.58 33 110413 175 46575441
Hepatitis E 106.28 10.58 54 110392 1185 46574431
Chest pain 106.05 10.58 158 110288 176166 46399450
Insomnia 105.94 10.58 141 110305 164783 46410833
Acute graft versus host disease in liver 105.78 10.58 44 110402 596 46575020
Cholangitis 105.62 10.58 88 110358 4586 46571030
Synovitis 102.71 10.58 12 110434 61063 46514553
Rheumatoid arthritis 101.53 10.58 265 110181 239950 46335666
Viral haemorrhagic cystitis 100.83 10.58 42 110404 571 46575045
Hepatosplenic T-cell lymphoma 99.85 10.58 42 110404 586 46575030
Intentional overdose 99.30 10.58 17 110429 64927 46510689
Human herpesvirus 8 infection 99.28 10.58 31 110415 168 46575448
Herpes simplex 99.15 10.58 103 110343 7120 46568496
Gait disturbance 98.68 10.58 119 110327 145144 46430472
Therapeutic product effect decreased 96.95 10.58 37 110409 82564 46493052
Muscle spasms 96.92 10.58 89 110357 123024 46452592
Cytomegalovirus chorioretinitis 96.34 10.58 54 110392 1453 46574163
Drug resistance 95.96 10.58 158 110288 17210 46558406
End stage renal disease 95.66 10.58 92 110354 5794 46569822
Brain abscess 95.06 10.58 56 110390 1659 46573957
Hypogammaglobulinaemia 94.10 10.58 88 110358 5350 46570266
Pre-eclampsia 93.94 10.58 105 110341 7889 46567727
Meningitis cryptococcal 93.61 10.58 49 110397 1146 46574470
Contusion 93.42 10.58 45 110401 87442 46488174
Shock haemorrhagic 92.42 10.58 108 110338 8516 46567100
Asthma 91.94 10.58 51 110395 91491 46484125
Lupus nephritis 90.77 10.58 60 110386 2186 46573430
Lung transplant 90.46 10.58 66 110380 2826 46572790
Injection site reaction 89.63 10.58 6 110440 47843 46527773
Malacoplakia 89.35 10.58 24 110422 67 46575549
Acute myeloid leukaemia recurrent 89.18 10.58 50 110396 1346 46574270
Polyomavirus test positive 89.09 10.58 24 110422 68 46575548
Drug level fluctuating 88.40 10.58 34 110412 370 46575246
Flushing 88.29 10.58 22 110424 64592 46511024
Nasopharyngitis 87.81 10.58 143 110303 153855 46421761
Cytomegalovirus enterocolitis 87.66 10.58 37 110409 521 46575095
Weight increased 87.15 10.58 160 110286 164313 46411303
Complications of transplant surgery 84.60 10.58 27 110419 159 46575457
Cerebrovascular accident 84.43 10.58 69 110377 100970 46474646
Alternaria infection 83.88 10.58 26 110420 137 46575479
Hyperhidrosis 82.37 10.58 55 110391 89253 46486363
Mycobacterial infection 81.90 10.58 50 110396 1583 46574033
Paraesthesia 81.03 10.58 95 110351 117342 46458274
Cytomegalovirus gastrointestinal infection 80.76 10.58 29 110417 256 46575360
Liver transplant 79.80 10.58 57 110389 2360 46573256
Musculoskeletal stiffness 79.33 10.58 69 110377 97924 46477692
Pneumatosis intestinalis 79.19 10.58 53 110393 1972 46573644
Heart rate increased 79.04 10.58 39 110407 74752 46500864
Abortion spontaneous 77.99 10.58 254 110192 43392 46532224
Complications of transplanted lung 77.95 10.58 27 110419 212 46575404
Renal graft infection 77.80 10.58 23 110423 100 46575516
Urticaria 77.51 10.58 99 110347 117793 46457823
Hyperammonaemia 77.18 10.58 74 110372 4642 46570974
Mycobacterium abscessus infection 77.18 10.58 35 110411 591 46575025
Glossodynia 76.42 10.58 8 110438 44365 46531251
Hypoaesthesia 75.92 10.58 102 110344 118767 46456849
Leukoencephalopathy 75.53 10.58 68 110378 3936 46571680
Histoplasmosis 75.31 10.58 48 110398 1642 46573974
Mycobacterium avium complex infection 75.14 10.58 57 110389 2591 46573025
Encephalitis viral 74.39 10.58 47 110399 1583 46574033
Renal tubular injury 74.32 10.58 29 110417 329 46575287
Escherichia urinary tract infection 74.06 10.58 106 110340 10217 46565399
MELAS syndrome 73.81 10.58 22 110424 99 46575517
Alveolar proteinosis 73.69 10.58 28 110418 294 46575322
Pneumonia bacterial 73.47 10.58 86 110360 6793 46568823
Escherichia bacteraemia 73.03 10.58 57 110389 2704 46572912
Human ehrlichiosis 73.00 10.58 25 110421 189 46575427
Graft versus host disease in lung 72.69 10.58 28 110418 306 46575310
Infection in an immunocompromised host 72.59 10.58 31 110415 450 46575166
Balance disorder 72.29 10.58 31 110415 64490 46511126
Musculoskeletal pain 71.97 10.58 38 110408 70090 46505526
Encapsulating peritoneal sclerosis 71.77 10.58 29 110417 363 46575253
Acute respiratory distress syndrome 71.05 10.58 159 110287 21763 46553853
Intestine transplant rejection 70.87 10.58 18 110428 37 46575579
New onset diabetes after transplantation 70.52 10.58 17 110429 25 46575591
Weight decreased 69.67 10.58 260 110186 210589 46365027
Pruritus 69.39 10.58 316 110130 242036 46333580
Myocardial infarction 69.33 10.58 77 110369 97451 46478165
Mycoplasma infection 69.24 10.58 29 110417 400 46575216
Rhodococcus infection 69.18 10.58 20 110426 79 46575537
Palpitations 69.05 10.58 74 110372 95185 46480431
Bacterial sepsis 68.11 10.58 61 110385 3506 46572110
Cerebral aspergillosis 67.62 10.58 27 110419 327 46575289
Fibromyalgia 67.05 10.58 5 110441 36458 46539158
Encephalitis cytomegalovirus 66.95 10.58 30 110416 492 46575124
Malignant neoplasm progression 66.90 10.58 35 110411 64891 46510725
Hepatic failure 66.63 10.58 202 110244 33214 46542402
Glomerulonephritis membranoproliferative 66.32 10.58 22 110424 149 46575467
Autoimmune haemolytic anaemia 66.28 10.58 65 110381 4193 46571423
Hyperuricaemia 66.07 10.58 68 110378 4649 46570967
Prophylaxis against transplant rejection 65.88 10.58 15 110431 14 46575602
Enterobacter infection 65.77 10.58 46 110400 1841 46573775
Dry mouth 65.45 10.58 24 110422 54902 46520714
Chronic graft versus host disease in liver 65.33 10.58 22 110424 157 46575459
Microtia 65.18 10.58 26 110420 314 46575302
Alopecia 65.04 10.58 628 109818 161786 46413830
Pleural mesothelioma malignant 64.78 10.58 17 110429 42 46575574
Osteoarthritis 64.55 10.58 33 110413 61992 46513624
Cleft palate 64.51 10.58 35 110411 882 46574734
Liver abscess 64.14 10.58 52 110394 2607 46573009
Loss of consciousness 64.05 10.58 98 110348 108140 46467476
Influenza like illness 63.96 10.58 28 110418 57542 46518074
Organising pneumonia 63.89 10.58 68 110378 4834 46570782
Bone marrow failure 63.58 10.58 184 110262 29485 46546131
Confusional state 63.29 10.58 182 110264 159710 46415906
Death 63.09 10.58 500 109946 335048 46240568
Injection site swelling 62.88 10.58 10 110436 40317 46535299
Pregnancy 62.75 10.58 173 110273 26964 46548652
Hypotension 62.63 10.58 310 110136 232279 46343337
Vomiting 62.55 10.58 728 109718 452066 46123550
Cardiac failure congestive 62.45 10.58 75 110371 91675 46483941
Memory impairment 61.93 10.58 55 110391 77282 46498334
Malacoplakia gastrointestinal 61.90 10.58 17 110429 53 46575563
Arthritis 61.89 10.58 55 110391 77261 46498355
Injection site pruritus 61.64 10.58 10 110436 39733 46535883
Chronic myeloid leukaemia 61.26 10.58 49 110397 2409 46573207
Bacterial pyelonephritis 61.16 10.58 25 110421 323 46575293
Decreased appetite 60.82 10.58 244 110202 193592 46382024
Cough 60.78 10.58 309 110137 229940 46345676
Hepatitis B 60.54 10.58 58 110388 3635 46571981
Liver function test abnormal 60.50 10.58 244 110202 46243 46529373
Mobility decreased 60.48 10.58 34 110412 60560 46515056
Pyelonephritis acute 60.46 10.58 61 110385 4073 46571543
Encephalopathy 59.58 10.58 195 110251 33394 46542222
Complications of transplanted heart 58.97 10.58 16 110430 47 46575569
Hydronephrosis 58.76 10.58 86 110360 8459 46567157
Gastroenteritis norovirus 58.72 10.58 40 110406 1533 46574083
Glomerulosclerosis 58.65 10.58 24 110422 311 46575305
Squamous cell carcinoma 58.48 10.58 82 110364 7754 46567862
Dysmorphism 58.47 10.58 43 110403 1864 46573752
Urinary tract infection bacterial 58.26 10.58 60 110386 4105 46571511
Dermatitis atopic 57.94 10.58 39 110407 1465 46574151
Epstein-Barr virus test positive 57.82 10.58 28 110418 552 46575064
Thrombotic thrombocytopenic purpura 57.74 10.58 58 110388 3852 46571764
Graft versus host disease in liver 57.71 10.58 26 110420 432 46575184
Suicide attempt 57.70 10.58 29 110417 55007 46520609
Osteonecrosis of jaw 57.24 10.58 7 110439 34395 46541221
Osmotic demyelination syndrome 56.92 10.58 28 110418 572 46575044
Adenoviral hepatitis 56.91 10.58 22 110424 243 46575373
Neck pain 56.70 10.58 30 110416 55276 46520340
Limb reduction defect 56.66 10.58 24 110422 341 46575275
Disease recurrence 56.56 10.58 131 110315 18340 46557276
Donor specific antibody present 56.40 10.58 14 110432 25 46575591
Glomerulonephritis 56.36 10.58 39 110407 1534 46574082
Renal tubular acidosis 56.13 10.58 39 110407 1544 46574072
Ureteric stenosis 55.83 10.58 28 110418 597 46575019
Bradycardia 55.71 10.58 45 110401 66253 46509363
Myalgia 55.67 10.58 131 110315 122957 46452659
Engraftment syndrome 55.35 10.58 22 110424 263 46575353
Immune reconstitution inflammatory syndrome 55.28 10.58 68 110378 5657 46569959
Nodular melanoma 54.80 10.58 15 110431 46 46575570
Pneumonia fungal 54.74 10.58 58 110388 4102 46571514
Coccidioidomycosis 54.71 10.58 31 110415 852 46574764
Pain in jaw 54.52 10.58 12 110434 38360 46537256
Passenger lymphocyte syndrome 54.32 10.58 15 110431 48 46575568
Wound 53.95 10.58 17 110429 42785 46532831
Vertigo 53.70 10.58 28 110418 52020 46523596
Neurotoxicity 53.14 10.58 107 110339 13610 46562006
Injection site bruising 53.01 10.58 10 110436 35626 46539990
Hepatic artery thrombosis 52.97 10.58 15 110431 54 46575562
Psoriatic arthropathy 52.46 10.58 11 110435 36368 46539248
Wrong technique in product usage process 52.24 10.58 32 110414 54390 46521226
Neuropathy peripheral 52.15 10.58 84 110362 90809 46484807
Therapeutic product effect incomplete 52.00 10.58 65 110381 78088 46497528
Erythema 51.92 10.58 169 110277 142651 46432965
Cytomegalovirus gastritis 51.73 10.58 19 110427 180 46575436
Visceral leishmaniasis 51.54 10.58 24 110422 432 46575184
Discomfort 51.36 10.58 23 110423 46647 46528969
Disseminated cryptococcosis 51.33 10.58 21 110425 272 46575344
Encephalitis 51.27 10.58 75 110371 7373 46568243
Pulmonary alveolar haemorrhage 51.20 10.58 56 110390 4106 46571510
Skin papilloma 51.04 10.58 56 110390 4120 46571496
Staphylococcal infection 50.80 10.58 193 110253 35578 46540038
Transplantation associated food allergy 50.49 10.58 10 110436 0 46575616
Wheezing 50.40 10.58 32 110414 53354 46522262
Colorectal cancer 50.08 10.58 30 110416 917 46574699
Device expulsion 50.01 10.58 4 110442 27538 46548078
Ascites 50.00 10.58 195 110251 36389 46539227
IgA nephropathy 49.90 10.58 23 110423 404 46575212
Disseminated intravascular coagulation 49.87 10.58 127 110319 18878 46556738
Coronavirus infection 49.86 10.58 46 110400 2748 46572868
Upper respiratory tract inflammation 49.85 10.58 46 110400 2749 46572867
Renal artery stenosis 49.66 10.58 38 110408 1750 46573866
Papilloma viral infection 49.48 10.58 34 110412 1322 46574294
Graft thrombosis 49.25 10.58 18 110428 168 46575448
Venoocclusive disease 48.76 10.58 39 110407 1917 46573699
Cytomegalovirus gastroenteritis 48.42 10.58 18 110428 177 46575439
Rash pruritic 48.33 10.58 22 110424 44193 46531423
Disseminated toxoplasmosis 48.24 10.58 15 110431 80 46575536
Acanthamoeba infection 48.21 10.58 13 110433 37 46575579
Disseminated mucormycosis 48.15 10.58 16 110430 109 46575507
Drug level above therapeutic 48.09 10.58 50 110396 3459 46572157
Feeling hot 47.92 10.58 15 110431 37913 46537703
Haemodialysis 47.12 10.58 81 110365 9136 46566480
Blood pressure increased 46.65 10.58 149 110297 126517 46449099
Drug ineffective for unapproved indication 46.56 10.58 113 110333 16300 46559316
Pancreas transplant 46.54 10.58 11 110435 14 46575602
Bacterial infection 46.39 10.58 112 110334 16104 46559512
Pulmonary nocardiosis 46.35 10.58 15 110431 93 46575523
Malacoplakia vesicae 46.30 10.58 13 110433 45 46575571
Dermatophytosis 46.29 10.58 17 110429 161 46575455
Stenotrophomonas infection 46.25 10.58 35 110411 1585 46574031
Haemolysis 46.11 10.58 64 110382 5995 46569621
Dysgeusia 46.08 10.58 19 110427 40472 46535144
Hot flush 45.51 10.58 23 110423 43494 46532122
Complications of bone marrow transplant 45.28 10.58 22 110424 437 46575179
Neutrophil Pelger-Huet anomaly present 45.13 10.58 14 110432 74 46575542
Drug intolerance 44.92 10.58 187 110259 146862 46428754
Hyperglycaemia 44.77 10.58 183 110263 34888 46540728
Renal disorder 44.72 10.58 152 110294 26534 46549082
Microsporidia infection 44.57 10.58 18 110428 225 46575391
Drug withdrawal syndrome 44.52 10.58 6 110440 27378 46548238
BK polyomavirus test positive 44.29 10.58 12 110434 35 46575581
Graft complication 44.28 10.58 17 110429 184 46575432
Biliary anastomosis complication 44.19 10.58 11 110435 20 46575596
Suicidal ideation 44.06 10.58 41 110405 56341 46519275
Babesiosis 44.04 10.58 12 110434 36 46575580
Perinephric collection 43.96 10.58 15 110431 112 46575504
Food allergy 43.70 10.58 67 110379 6866 46568750
Escherichia sepsis 43.63 10.58 52 110394 4186 46571430
Orf 43.51 10.58 11 110435 22 46575594
Acinetobacter infection 43.45 10.58 32 110414 1390 46574226
Intentional product use issue 43.06 10.58 242 110204 52538 46523078
Oedema peripheral 42.87 10.58 213 110233 159493 46416123
Sarcoma of skin 42.87 10.58 11 110435 24 46575592
Trichophytosis 42.86 10.58 12 110434 41 46575575
Renal tubular disorder 42.86 10.58 40 110406 2425 46573191
Cytomegalovirus hepatitis 42.65 10.58 19 110427 307 46575309
Anogenital warts 42.55 10.58 20 110426 368 46575248
Anti-erythropoietin antibody negative 42.50 10.58 13 110433 65 46575551
Adenoviral haemorrhagic cystitis 42.42 10.58 15 110431 126 46575490
Premature baby 42.40 10.58 116 110330 17996 46557620
Central nervous system viral infection 42.31 10.58 14 110432 94 46575522
Blood pressure fluctuation 42.30 10.58 10 110436 30438 46545178
Enterocolitis 42.30 10.58 62 110384 6106 46569510
Penicillium infection 41.93 10.58 14 110432 97 46575519
Lactic acidosis 41.80 10.58 14 110432 33895 46541721
Drug level below therapeutic 41.74 10.58 44 110402 3093 46572523
Bacillary angiomatosis 41.70 10.58 13 110433 70 46575546
Cerebral microhaemorrhage 41.33 10.58 14 110432 102 46575514
Abdominal pain upper 41.21 10.58 190 110256 145115 46430501
Throat irritation 41.14 10.58 9 110437 28892 46546724
Hepatic function abnormal 41.12 10.58 176 110270 34245 46541371
Locked-in syndrome 41 10.58 19 110427 338 46575278
Lymphopenia 40.96 10.58 103 110343 15190 46560426
Ureteral necrosis 40.81 10.58 12 110434 51 46575565
Renal abscess 40.73 10.58 23 110423 628 46574988
Dysphonia 40.62 10.58 20 110426 38394 46537222
Interstitial lung disease 40.52 10.58 242 110204 53707 46521909
Angiosarcoma 40.49 10.58 17 110429 236 46575380
Dyspepsia 40.49 10.58 62 110384 68410 46507206
Bone pain 40.44 10.58 31 110415 46859 46528757
Nervousness 40.26 10.58 9 110437 28466 46547150
Liver transplant failure 40.24 10.58 10 110436 18 46575598
Myelosuppression 39.78 10.58 68 110378 7635 46567981
Epstein-Barr virus infection reactivation 39.67 10.58 17 110429 249 46575367
Pneumonia influenzal 39.58 10.58 31 110415 1478 46574138
Pseudomonal bacteraemia 39.33 10.58 29 110417 1262 46574354
Meningoencephalitis herpetic 39.26 10.58 27 110419 1051 46574565
Fungal infection 39.25 10.58 156 110290 29364 46546252
Parainfluenzae virus infection 39.09 10.58 33 110413 1751 46573865
Post procedural bile leak 38.95 10.58 14 110432 124 46575492
Knee arthroplasty 38.92 10.58 5 110441 23660 46551956
Emphysematous pyelonephritis 38.77 10.58 15 110431 166 46575450
Bile duct stenosis 38.75 10.58 27 110419 1074 46574542
Adverse drug reaction 38.68 10.58 29 110417 44333 46531283
Oxygen saturation decreased 38.66 10.58 65 110381 69099 46506517
Vision blurred 38.33 10.58 82 110364 79626 46495990
Maternal exposure during pregnancy 38.32 10.58 391 110055 102158 46473458
Nephropathy 38.28 10.58 53 110393 4952 46570664
Staphylococcal sepsis 38.25 10.58 66 110380 7466 46568150
Injury 38.10 10.58 29 110417 43998 46531618
Unevaluable event 37.98 10.58 32 110414 46143 46529473
Hepatic necrosis 37.97 10.58 56 110390 5545 46570071
Swollen tongue 37.95 10.58 11 110435 29221 46546395
Normocytic anaemia 37.92 10.58 27 110419 1112 46574504
Low birth weight baby 37.81 10.58 55 110391 5379 46570237
Agranulocytosis 37.74 10.58 127 110319 22058 46553558
Chronic graft versus host disease in intestine 37.69 10.58 12 110434 70 46575546
Reticulocytopenia 37.55 10.58 12 110434 71 46575545
Engraft failure 37.30 10.58 18 110428 352 46575264
Treatment noncompliance 37.05 10.58 154 110292 29577 46546039
Urate nephropathy 37.00 10.58 13 110433 107 46575509
Pneumonia klebsiella 36.94 10.58 34 110412 2025 46573591
Vesicoureteric reflux 36.82 10.58 15 110431 192 46575424
Renal necrosis 36.82 10.58 11 110435 50 46575566
Drug reaction with eosinophilia and systemic symptoms 36.77 10.58 12 110434 29536 46546080
Bronchitis 36.73 10.58 128 110318 105851 46469765
Hypertrophic osteoarthropathy 36.70 10.58 10 110436 30 46575586
Blastomycosis 36.58 10.58 16 110430 247 46575369
Speech disorder 36.51 10.58 20 110426 36147 46539469
Orthostatic hypotension 36.50 10.58 7 110439 24651 46550965
Hypokalaemia 36.43 10.58 98 110348 87926 46487690
Rhinovirus infection 36.43 10.58 44 110402 3592 46572024
Microangiopathic haemolytic anaemia 36.35 10.58 19 110427 443 46575173
Epistaxis 36.34 10.58 60 110386 64245 46511371
Hepatic fibrosis 36.32 10.58 40 110406 2955 46572661
Scleroderma renal crisis 36.12 10.58 16 110430 255 46575361
Device issue 36.00 10.58 3 110443 19977 46555639
Atrial fibrillation 35.98 10.58 125 110321 103465 46472151
Agitation 35.92 10.58 47 110399 55368 46520248
Heart rate decreased 35.91 10.58 15 110431 31708 46543908
Adverse event 35.84 10.58 18 110428 34166 46541450
Tooth disorder 35.83 10.58 6 110440 23297 46552319
Depressed mood 35.76 10.58 17 110429 33302 46542314
Chronic kidney disease 35.76 10.58 191 110255 40680 46534936
Blood potassium decreased 35.68 10.58 23 110423 38040 46537576
Peritonitis 35.61 10.58 119 110327 20595 46555021
Gastroenteritis eosinophilic 35.47 10.58 12 110434 87 46575529
Fungal sepsis 35.47 10.58 26 110420 1121 46574495
Pyelonephritis fungal 35.41 10.58 13 110433 123 46575493
Central nervous system fungal infection 35.35 10.58 12 110434 88 46575528
Congenital nail disorder 35.35 10.58 12 110434 88 46575528
Eczema herpeticum 35.35 10.58 12 110434 88 46575528
Upper respiratory fungal infection 35.32 10.58 13 110433 124 46575492
Urinary fistula 35.27 10.58 9 110437 19 46575597
Oesophageal candidiasis 35.27 10.58 52 110394 5148 46570468
Anorexia nervosa 35.03 10.58 14 110432 170 46575446
Device dislocation 34.92 10.58 5 110441 21797 46553819
Abdominal wall infection 34.89 10.58 12 110434 92 46575524
External auditory canal atresia 34.58 10.58 11 110435 64 46575552
Herpes simplex hepatitis 34.46 10.58 16 110430 286 46575330
Brain oedema 34.43 10.58 85 110361 12393 46563223
Sleep disorder 34.29 10.58 36 110410 46759 46528857
Proteus infection 34.10 10.58 23 110423 867 46574749
Thrombocytopenia 34.07 10.58 453 109993 126128 46449488
Pyrexia 33.98 10.58 1072 109374 347730 46227886
Oesophageal atresia 33.97 10.58 19 110427 509 46575107
Type 1 diabetes mellitus 33.81 10.58 38 110408 2872 46572744
Evans syndrome 33.76 10.58 14 110432 188 46575428
Glomerulonephritis rapidly progressive 33.70 10.58 21 110425 690 46574926
Fungal endocarditis 33.58 10.58 15 110431 244 46575372
Oropharyngeal pain 33.46 10.58 79 110367 74089 46501527
Anaphylactic reaction 33.45 10.58 46 110400 53066 46522550
Hypoalbuminaemia 33.43 10.58 74 110372 10053 46565563
Serum sickness 33.41 10.58 35 110411 2443 46573173
Rectal haemorrhage 33.36 10.58 25 110421 38230 46537386
Stress 33.13 10.58 44 110402 51507 46524109
Hepatic artery stenosis 33.09 10.58 8 110438 12 46575604
Gastroenteritis 33.01 10.58 129 110317 24090 46551526
Guillain-Barre syndrome 32.95 10.58 40 110406 3282 46572334
Subarachnoid haemorrhage 32.94 10.58 78 110368 11075 46564541
Neoplasm progression 32.92 10.58 11 110435 26672 46548944
Gastrooesophageal reflux disease 32.90 10.58 80 110366 74264 46501352
Multiple sclerosis 32.79 10.58 9 110437 24782 46550834
Neutropenia 32.75 10.58 498 109948 142706 46432910
Anuria 32.75 10.58 79 110367 11352 46564264
Actinic keratosis 32.67 10.58 33 110413 2206 46573410
Dysplasia 32.65 10.58 20 110426 637 46574979
Injection site haemorrhage 32.59 10.58 5 110441 20704 46554912
Disseminated aspergillosis 32.55 10.58 9 110437 29 46575587
Capillaritis 32.49 10.58 11 110435 80 46575536
Swelling face 32.38 10.58 47 110399 53012 46522604
Dialysis 32.36 10.58 73 110373 10043 46565573
Placenta accreta 32.30 10.58 13 110433 161 46575455
Kaposi's sarcoma 32.30 10.58 13 110433 161 46575455
Bone marrow transplant 32.29 10.58 20 110426 650 46574966
Subcapsular renal haematoma 32.26 10.58 15 110431 269 46575347
Varicella 32.23 10.58 29 110417 1677 46573939
Epidermodysplasia verruciformis 32.21 10.58 10 110436 53 46575563
Presyncope 32.12 10.58 9 110437 24445 46551171
Klebsiella sepsis 32.07 10.58 26 110420 1303 46574313
American trypanosomiasis 31.75 10.58 10 110436 56 46575560
Porokeratosis 31.75 10.58 12 110434 124 46575492
Dry eye 31.74 10.58 16 110430 30306 46545310
Azotaemia 31.68 10.58 45 110401 4306 46571310
Beta-N-acetyl-D-glucosaminidase increased 31.66 10.58 9 110437 33 46575583
Post procedural urine leak 31.66 10.58 9 110437 33 46575583
Lower respiratory tract infection 31.51 10.58 51 110395 55038 46520578
Hypoglycaemia 31.38 10.58 50 110396 54299 46521317
Clostridium difficile colitis 31.37 10.58 106 110340 18447 46557169
Enterovirus infection 31.31 10.58 19 110427 595 46575021
Crying 31.30 10.58 6 110440 21135 46554481
Accidental exposure to product 31.17 10.58 6 110440 21075 46554541
Heart disease congenital 31.13 10.58 25 110421 1236 46574380
Splenomegaly 31.09 10.58 70 110376 9618 46565998
Skin graft rejection 31.01 10.58 8 110438 18 46575598
Steroid diabetes 30.69 10.58 19 110427 617 46574999
Pneumonia pseudomonal 30.66 10.58 31 110415 2075 46573541
Plasma cell myeloma 30.63 10.58 36 110410 44442 46531174
Toxic encephalopathy 30.62 10.58 48 110398 5014 46570602
Graft ischaemia 30.47 10.58 9 110437 39 46575577
Fluid retention 30.39 10.58 46 110400 51000 46524616
Disseminated cytomegaloviral infection 30.35 10.58 11 110435 100 46575516
Cholestasis 30.21 10.58 135 110311 26758 46548858
Necrotising fasciitis 30.04 10.58 34 110412 2589 46573027
Superinfection bacterial 29.97 10.58 16 110430 390 46575226
Pneumomediastinum 29.71 10.58 24 110422 1197 46574419
Meningitis bacterial 29.62 10.58 24 110422 1202 46574414
Coagulation test abnormal 29.60 10.58 19 110427 658 46574958
Full blood count decreased 29.50 10.58 8 110438 22203 46553413
Diffuse alveolar damage 29.26 10.58 20 110426 771 46574845
Subcutaneous abscess 29.24 10.58 47 110399 5016 46570600
Pneumocystis jirovecii infection 29.09 10.58 24 110422 1233 46574383
Pulmonary embolism 29.02 10.58 145 110301 108440 46467176
Atypical mycobacterial infection 28.99 10.58 21 110425 889 46574727
Migraine 28.94 10.58 78 110368 69948 46505668
Endocarditis enterococcal 28.94 10.58 9 110437 48 46575568
Epstein-Barr virus associated lymphoma 28.82 10.58 14 110432 278 46575338
Metastatic squamous cell carcinoma 28.80 10.58 13 110433 217 46575399
Granuloma 28.72 10.58 40 110406 3758 46571858
Renal artery thrombosis 28.71 10.58 10 110436 80 46575536
Squamous cell carcinoma of skin 28.66 10.58 47 110399 5100 46570516
Sebaceous carcinoma 28.65 10.58 8 110438 27 46575589
Liver disorder 28.56 10.58 168 110278 37078 46538538
Periostitis 28.53 10.58 13 110433 222 46575394
Chronic hepatitis C 28.49 10.58 12 110434 168 46575448
Lymphoma 28.31 10.58 68 110378 9745 46565871
Limb hypoplasia congenital 28.30 10.58 12 110434 171 46575445
Genital herpes 28.18 10.58 26 110420 1553 46574063
Glomerulonephritis proliferative 28.11 10.58 12 110434 174 46575442
Premature labour 28.09 10.58 74 110372 11225 46564391
Breast cancer 28.09 10.58 40 110406 45478 46530138
Pulmonary mucormycosis 27.98 10.58 10 110436 87 46575529
Muscular weakness 27.90 10.58 117 110329 91727 46483889
Trichosporon infection 27.81 10.58 13 110433 236 46575380
Angiocentric lymphoma 27.81 10.58 16 110430 453 46575163
Transient ischaemic attack 27.72 10.58 25 110421 34878 46540738
Disseminated trichosporonosis 27.69 10.58 7 110439 14 46575602
Escherichia pyelonephritis 27.68 10.58 15 110431 377 46575239
C-reactive protein abnormal 27.62 10.58 8 110438 21262 46554354
Cardiac disorder 27.61 10.58 38 110408 43820 46531796
Biloma 27.51 10.58 9 110437 58 46575558
Enterococcal bacteraemia 27.48 10.58 23 110423 1206 46574410
Cytomegalovirus nephritis 27.36 10.58 7 110439 15 46575601
Histoplasmosis cutaneous 27.36 10.58 7 110439 15 46575601
Localised infection 27.35 10.58 11 110435 23790 46551826
Haemorrhage intracranial 27.34 10.58 79 110367 12645 46562971
Aspergillus test positive 27.32 10.58 14 110432 313 46575303
Disseminated varicella zoster vaccine virus infection 27.25 10.58 9 110437 60 46575556
Inappropriate schedule of product administration 27.19 10.58 72 110374 64941 46510675
Steroid withdrawal syndrome 27.13 10.58 16 110430 475 46575141
Nasal congestion 27.08 10.58 45 110401 48068 46527548
Fryns syndrome 27.00 10.58 9 110437 62 46575554
Endocarditis 26.88 10.58 45 110401 4967 46570649
Congenital diaphragmatic hernia 26.88 10.58 12 110434 195 46575421
Respiratory syncytial virus infection 26.72 10.58 44 110402 4791 46570825
Large intestinal ulcer 26.69 10.58 35 110411 3104 46572512
Conjunctival melanoma 26.67 10.58 6 110440 5 46575611
Eosinophilic oesophagitis 26.66 10.58 12 110434 199 46575417
Gastroenteritis adenovirus 26.58 10.58 11 110435 147 46575469
Renal ischaemia 26.55 10.58 17 110429 586 46575030
Psoriasis 26.52 10.58 96 110350 78508 46497108
Hip fracture 26.35 10.58 15 110431 26541 46549075
Subcutaneous emphysema 26.15 10.58 19 110427 808 46574808
Toothache 26.12 10.58 4 110442 16588 46559028
Cardio-respiratory arrest 26.03 10.58 65 110381 59804 46515812
Cerebral toxoplasmosis 26.01 10.58 18 110428 708 46574908
Gastrointestinal lymphoma 25.99 10.58 8 110438 41 46575575
Surgical procedure repeated 25.97 10.58 12 110434 212 46575404
Joint stiffness 25.93 10.58 16 110430 27092 46548524
Drug level changed 25.93 10.58 11 110435 157 46575459
Human herpesvirus 6 encephalitis 25.90 10.58 10 110436 110 46575506
Clostridial infection 25.86 10.58 41 110405 4324 46571292
Pancreatitis necrotising 25.86 10.58 24 110422 1445 46574171
Fungal skin infection 25.85 10.58 37 110409 3565 46572051
Cerebral fungal infection 25.83 10.58 8 110438 42 46575574
Necrotising retinitis 25.80 10.58 13 110433 280 46575336
Candida sepsis 25.77 10.58 23 110423 1316 46574300
Enterococcal sepsis 25.75 10.58 23 110423 1317 46574299
Lupus enteritis 25.73 10.58 9 110437 73 46575543
Pancreatic leak 25.67 10.58 6 110440 7 46575609
Poor quality sleep 25.63 10.58 3 110443 15250 46560366
Urinary tract infection pseudomonal 25.62 10.58 19 110427 834 46574782
Central nervous system infection 25.58 10.58 17 110429 625 46574991
Pulmonary haemorrhage 25.50 10.58 51 110395 6454 46569162
Limb discomfort 25.41 10.58 11 110435 22765 46552851
Aggression 25.35 10.58 11 110435 22733 46552883
Hair follicle tumour benign 25.27 10.58 14 110432 368 46575248
Hepatic artery aneurysm 25.23 10.58 6 110440 8 46575608
Chills 25.22 10.58 129 110317 95903 46479713
Hepatic cyst infection 25.20 10.58 10 110436 119 46575497
Lethargy 25.14 10.58 52 110394 51119 46524497
Renal haematoma 25.14 10.58 11 110435 170 46575446
Pneumonia pneumococcal 25.08 10.58 26 110420 1792 46573824
Treatment failure 25.04 10.58 124 110322 92963 46482653
Retrognathia 25.03 10.58 13 110433 299 46575317
Cutaneous leishmaniasis 25.01 10.58 9 110437 80 46575536
Urinary tract infection viral 24.98 10.58 7 110439 24 46575592
Blood albumin increased 24.98 10.58 19 110427 867 46574749
Pleural effusion 24.91 10.58 303 110143 82649 46492967
Blood cholesterol increased 24.85 10.58 35 110411 39978 46535638
Histology abnormal 24.83 10.58 10 110436 124 46575492
Muir-Torre syndrome 24.76 10.58 7 110439 25 46575591
Sopor 24.76 10.58 8 110438 19820 46555796
Blood beta-D-glucan increased 24.76 10.58 12 110434 237 46575379
Avian influenza 24.66 10.58 8 110438 50 46575566
Diaphragmatic hernia 24.60 10.58 14 110432 388 46575228
Pallor 24.59 10.58 12 110434 23154 46552462
Gingival hypertrophy 24.48 10.58 23 110423 1406 46574210
Acute hepatitis C 24.44 10.58 9 110437 86 46575530
Systemic bacterial infection 24.43 10.58 6 110440 10 46575606
Femur fracture 24.36 10.58 31 110415 36966 46538650
Amnesia 24.32 10.58 38 110408 41593 46534023
Drug specific antibody absent 24.27 10.58 8 110438 53 46575563
Herpes simplex oesophagitis 24.20 10.58 10 110436 133 46575483
Intervertebral disc protrusion 24.16 10.58 9 110437 20396 46555220
Dysstasia 24.16 10.58 6 110440 17662 46557954
Beta 2 microglobulin urine increased 24.14 10.58 8 110438 54 46575562
Congenital oral malformation 24.14 10.58 11 110435 188 46575428
Ill-defined disorder 24.08 10.58 17 110429 26810 46548806
Musculoskeletal disorder 23.91 10.58 4 110442 15541 46560075
Gastric disorder 23.87 10.58 17 110429 26688 46548928
Stomatococcal infection 23.81 10.58 9 110437 93 46575523
Hypersomnia 23.68 10.58 4 110442 15435 46560181
Nosocomial infection 23.68 10.58 24 110422 1611 46574005
Bone marrow oedema 23.64 10.58 18 110428 823 46574793
Perinephric abscess 23.61 10.58 10 110436 142 46575474
Molluscum contagiosum 23.57 10.58 11 110435 199 46575417
Joint injury 23.55 10.58 8 110438 19201 46556415
Nephrogenic systemic fibrosis 23.17 10.58 41 110405 4731 46570885
Hip arthroplasty 23.17 10.58 7 110439 18105 46557511
Gestational hypertension 23.11 10.58 27 110419 2128 46573488
Renal and pancreas transplant rejection 23.10 10.58 6 110440 14 46575602
Cholangitis infective 23.06 10.58 10 110436 151 46575465
Increased insulin requirement 22.97 10.58 8 110438 64 46575552
Pulmonary hypoplasia 22.91 10.58 12 110434 281 46575335
Biliary ischaemia 22.90 10.58 5 110441 3 46575613
Red blood cell count decreased 22.90 10.58 26 110420 32597 46543019
Perihepatic abscess 22.81 10.58 6 110440 15 46575601
Chromaturia 22.80 10.58 4 110442 15015 46560601
Pericardial effusion 22.77 10.58 120 110326 25423 46550193
Erythema infectiosum 22.76 10.58 9 110437 106 46575510
Mediastinitis 22.75 10.58 11 110435 216 46575400
Meningitis 22.74 10.58 47 110399 6089 46569527
Splenic vein thrombosis 22.72 10.58 12 110434 286 46575330
Pulmonary arterial hypertension 22.53 10.58 17 110429 25911 46549705
Hydrocephalus 22.53 10.58 41 110405 4836 46570780
Cat scratch disease 22.48 10.58 10 110436 161 46575455
Fat necrosis 22.44 10.58 15 110431 557 46575059
Injection site warmth 22.43 10.58 3 110443 13769 46561847
B-cell lymphoma 22.43 10.58 33 110413 3261 46572355
Restless legs syndrome 22.41 10.58 5 110441 15838 46559778
Orbital apex syndrome 22.41 10.58 7 110439 38 46575578
Citrobacter infection 22.41 10.58 13 110433 374 46575242
Rhesus antigen positive 22.39 10.58 9 110437 111 46575505
Staphylococcal bacteraemia 22.37 10.58 41 110405 4863 46570753
Demodicidosis 22.32 10.58 5 110441 4 46575612
Acute allograft nephropathy 22.32 10.58 5 110441 4 46575612
Fusarium infection 22.30 10.58 15 110431 563 46575053
Anaphylactic shock 22.29 10.58 10 110436 20264 46555352
Caesarean section 22.28 10.58 88 110358 16515 46559101
Milk allergy 22.21 10.58 10 110436 166 46575450
Unresponsive to stimuli 22.20 10.58 26 110420 32148 46543468
Stem cell transplant 22.14 10.58 24 110422 1742 46573874
Pelvic deformity 22.13 10.58 11 110435 230 46575386
Disseminated mycobacterium avium complex infection 22.11 10.58 7 110439 40 46575576
Squamous cell carcinoma of the vulva 22.02 10.58 6 110440 18 46575598
Eye swelling 21.97 10.58 10 110436 20093 46555523
Cytomegalovirus oesophagitis 21.96 10.58 11 110435 234 46575382
Cholelithiasis 21.94 10.58 36 110410 38645 46536971
Restlessness 21.84 10.58 17 110429 25507 46550109
Bone disorder 21.84 10.58 10 110436 20023 46555593
Procedural failure 21.79 10.58 5 110441 5 46575611
Granulomatous rosacea 21.78 10.58 6 110440 19 46575597
Haemodynamic instability 21.71 10.58 53 110393 7672 46567944
Hepatic infarction 21.70 10.58 15 110431 589 46575027
Arteritis infective 21.68 10.58 7 110439 43 46575573
Arteriovenous fistula occlusion 21.61 10.58 12 110434 317 46575299
Device malfunction 21.58 10.58 3 110443 13371 46562245
Neuropsychiatric lupus 21.56 10.58 9 110437 123 46575493
Foot deformity 21.56 10.58 5 110441 15420 46560196
Meningomyelitis herpes 21.54 10.58 6 110440 20 46575596
Bursitis 21.48 10.58 10 110436 19832 46555784
Diverticulitis 21.43 10.58 28 110418 33011 46542605
Skin mass 21.43 10.58 42 110404 5238 46570378
Reperfusion injury 21.41 10.58 7 110439 45 46575571
Abdominal distension 21.32 10.58 95 110351 73256 46502360
Bone marrow granuloma 21.32 10.58 6 110440 21 46575595
Biliary tract infection fungal 21.32 10.58 5 110441 6 46575610
Autoimmune hepatitis 21.32 10.58 53 110393 7761 46567855
Blood glucose decreased 21.28 10.58 9 110437 18883 46556733
Sedation 21.26 10.58 14 110432 22896 46552720
Microangiopathy 21.23 10.58 17 110429 837 46574779
Intrauterine infection 21.22 10.58 8 110438 82 46575534
Red blood cell sedimentation rate increased 21.22 10.58 14 110432 22875 46552741
Tremor 21.22 10.58 388 110058 115251 46460365
Adult T-cell lymphoma/leukaemia 21.17 10.58 12 110434 330 46575286
Opportunistic infection 21.12 10.58 23 110423 1678 46573938
Urosepsis 21.11 10.58 82 110364 15271 46560345
Nephrocalcinosis 21.10 10.58 18 110428 969 46574647
Aplastic anaemia 21.10 10.58 50 110396 7103 46568513
Arterial rupture 21.07 10.58 12 110434 333 46575283
Tracheo-oesophageal fistula 21.06 10.58 14 110432 515 46575101
Protein urine present 21.05 10.58 41 110405 5090 46570526
Pollakiuria 20.97 10.58 16 110430 24245 46551371
Diabetic macroangiopathy 20.93 10.58 9 110437 133 46575483
Removal of renal transplant 20.89 10.58 5 110441 7 46575609
Angiosarcoma metastatic 20.89 10.58 5 110441 7 46575609
Blood lactate dehydrogenase increased 20.88 10.58 100 110346 20400 46555216
Leiomyosarcoma 20.84 10.58 10 110436 193 46575423
Urinary incontinence 20.84 10.58 22 110424 28508 46547108
Blue toe syndrome 20.75 10.58 12 110434 343 46575273
Respiratory distress 20.75 10.58 138 110308 31778 46543838
Heart rate irregular 20.71 10.58 9 110437 18582 46557034
Ileal ulcer 20.68 10.58 13 110433 434 46575182
Parvovirus infection 20.56 10.58 10 110436 199 46575417
Delayed engraftment 20.55 10.58 7 110439 52 46575564
Lacrimation increased 20.53 10.58 6 110440 15855 46559761
Fungal abscess central nervous system 20.49 10.58 5 110441 8 46575608
Cleft lip and palate 20.48 10.58 12 110434 352 46575264
Toxicity to various agents 20.35 10.58 650 109796 211116 46364500
Neurofibrosarcoma 20.34 10.58 9 110437 143 46575473
Disturbance in attention 20.21 10.58 27 110419 31533 46544083
Drug level 20.20 10.58 4 110442 0 46575616
Hiatus hernia 20.17 10.58 9 110437 18293 46557323
Sinus disorder 20.13 10.58 7 110439 16556 46559060
Mucinous adenocarcinoma of appendix 20.12 10.58 5 110441 9 46575607
Acid fast bacilli infection 20.10 10.58 7 110439 56 46575560
Therapeutic response unexpected 20.04 10.58 6 110440 15610 46560006
Septic embolus 20.03 10.58 16 110430 785 46574831
Cardiac tamponade 20.01 10.58 37 110409 4417 46571199
Impaired work ability 20.00 10.58 3 110443 12633 46562983
Renal vein thrombosis 20.00 10.58 11 110435 285 46575331
Leukaemic infiltration extramedullary 19.99 10.58 7 110439 57 46575559
Delusional disorder, persecutory type 19.95 10.58 9 110437 150 46575466
Emotional distress 19.94 10.58 26 110420 30681 46544935
Eye infection toxoplasmal 19.93 10.58 11 110435 287 46575329
Gait inability 19.74 10.58 33 110413 35170 46540446
Polyhydramnios 19.72 10.58 24 110422 1975 46573641
Portal hypertension 19.66 10.58 32 110414 3451 46572165
Dysphagia 19.65 10.58 105 110341 77207 46498409
Chronic hepatitis 19.63 10.58 16 110430 808 46574808
Graft versus host disease in eye 19.57 10.58 7 110439 61 46575555
Vascular pseudoaneurysm 19.52 10.58 20 110426 1360 46574256
Burning sensation 19.48 10.58 48 110398 44363 46531253
Underdose 19.47 10.58 11 110435 19547 46556069
Product quality issue 19.46 10.58 34 110412 35614 46540002
Pseudallescheria infection 19.46 10.58 5 110441 11 46575605
Pneumonia staphylococcal 19.40 10.58 28 110418 2719 46572897
Intussusception 19.37 10.58 13 110433 486 46575130
Enterocolitis viral 19.29 10.58 10 110436 229 46575387
Urine output decreased 19.29 10.58 64 110382 11033 46564583
Panic attack 19.29 10.58 12 110434 20230 46555386
Tracheobronchitis 19.25 10.58 18 110428 1094 46574522
Tendonitis 19.23 10.58 5 110441 14272 46561344
Flatulence 19.22 10.58 24 110422 28854 46546762
Disseminated varicella zoster virus infection 19.21 10.58 15 110431 712 46574904
Impaired healing 19.20 10.58 36 110410 36707 46538909
Talipes 19.19 10.58 20 110426 1387 46574229
Eosinophilic colitis 19.19 10.58 8 110438 109 46575507
Biliary fistula 19.16 10.58 5 110441 12 46575604
Sporotrichosis 19.16 10.58 5 110441 12 46575604
Head injury 19.14 10.58 18 110428 24618 46550998
Encephalitis autoimmune 19.08 10.58 18 110428 1106 46574510
Legionella infection 19.02 10.58 12 110434 403 46575213
Growth failure 19.01 10.58 11 110435 315 46575301
Viral diarrhoea 18.93 10.58 8 110438 113 46575503
Periportal oedema 18.87 10.58 5 110441 13 46575603
Community acquired infection 18.87 10.58 5 110441 13 46575603
General physical health deterioration 18.79 10.58 179 110267 115590 46460026
Carpal tunnel syndrome 18.77 10.58 7 110439 15852 46559764
Focal myositis 18.70 10.58 6 110440 36 46575580
Portal vein thrombosis 18.68 10.58 26 110420 2441 46573175
Pneumothorax spontaneous 18.64 10.58 13 110433 518 46575098
Hyperoxaluria 18.62 10.58 8 110438 118 46575498
Epileptic encephalopathy 18.61 10.58 10 110436 247 46575369
Nephrogenic diabetes insipidus 18.57 10.58 15 110431 748 46574868
Biliary obstruction 18.50 10.58 26 110420 2463 46573153
Anastomotic complication 18.50 10.58 8 110438 120 46575496
Chronic graft versus host disease oral 18.43 10.58 6 110440 38 46575578
Pneumonia herpes viral 18.43 10.58 6 110440 38 46575578
Blood calcium decreased 18.41 10.58 7 110439 15666 46559950
Irritable bowel syndrome 18.39 10.58 8 110438 16507 46559109
Splenic abscess 18.38 10.58 7 110439 74 46575542
COVID-19 pneumonia 18.36 10.58 30 110416 3245 46572371
Trichostasis spinulosa 18.35 10.58 5 110441 15 46575601
Pericarditis constrictive 18.34 10.58 11 110435 337 46575279
Anger 18.34 10.58 3 110443 11849 46563767
Heart transplant 18.33 10.58 12 110434 430 46575186
Transplant 18.33 10.58 14 110432 643 46574973
Musculoskeletal chest pain 18.29 10.58 10 110436 18096 46557520
Metapneumovirus infection 18.24 10.58 15 110431 767 46574849
Acid base balance abnormal 18.15 10.58 10 110436 260 46575356
Skin hypertrophy 18.13 10.58 29 110417 3082 46572534
Pterygium colli 18.11 10.58 5 110441 16 46575600
Haematemesis 18.09 10.58 25 110421 28781 46546835
Feeling cold 18.06 10.58 11 110435 18760 46556856
International normalised ratio increased 18.06 10.58 54 110392 46829 46528787
Abnormal behaviour 18.05 10.58 14 110432 21044 46554572
Osteomyelitis fungal 17.97 10.58 4 110442 3 46575613
Pneumonia respiratory syncytial viral 17.96 10.58 14 110432 663 46574953
Plasmapheresis 17.94 10.58 10 110436 266 46575350
Cutaneous T-cell lymphoma 17.93 10.58 19 110427 1344 46574272
Infective keratitis 17.92 10.58 6 110440 42 46575574
Moraxella infection 17.91 10.58 11 110435 352 46575264
Acute motor axonal neuropathy 17.88 10.58 5 110441 17 46575599
Chylothorax 17.84 10.58 10 110436 269 46575347
Visual impairment 17.84 10.58 89 110357 66600 46509016
Moyamoya disease 17.80 10.58 6 110440 43 46575573
Eye pain 17.79 10.58 24 110422 27916 46547700
Throat cancer 17.78 10.58 12 110434 453 46575163
Malignant ascites 17.73 10.58 16 110430 929 46574687
Cognitive disorder 17.68 10.58 38 110408 36845 46538771
Idiopathic pneumonia syndrome 17.66 10.58 11 110435 361 46575255
Respiratory tract infection viral 17.61 10.58 22 110424 1859 46573757
Road traffic accident 17.61 10.58 18 110428 23673 46551943
Aeromonas infection 17.59 10.58 7 110439 84 46575532
Gastritis fungal 17.59 10.58 7 110439 84 46575532
Acute myeloid leukaemia 17.56 10.58 79 110367 15699 46559917
Muscle spasticity 17.47 10.58 3 110443 11437 46564179
Cytopenia 17.44 10.58 49 110397 7719 46567897
Fascioliasis 17.43 10.58 4 110442 4 46575612
Transplant abscess 17.43 10.58 4 110442 4 46575612
Extranodal marginal zone B-cell lymphoma (MALT type) stage IV 17.43 10.58 4 110442 4 46575612
Coinfection 17.43 10.58 4 110442 4 46575612
Desmoplastic melanoma 17.43 10.58 4 110442 4 46575612
Clostridium test positive 17.40 10.58 22 110424 1882 46573734
Bronchiectasis 17.34 10.58 55 110391 9261 46566355
Lymphadenopathy 17.28 10.58 137 110309 33351 46542265
Ischaemic nephropathy 17.25 10.58 5 110441 20 46575596
Dyspnoea exertional 17.24 10.58 61 110385 50228 46525388
Glomerulonephropathy 17.23 10.58 7 110439 89 46575527
Coombs positive haemolytic anaemia 17.19 10.58 11 110435 379 46575237
Oral pain 17.15 10.58 20 110426 24777 46550839
Renal atrophy 17.15 10.58 18 110428 1259 46574357
Graft infection 17.14 10.58 9 110437 212 46575404
Disease progression 17.11 10.58 136 110310 91164 46484452
Extrapyramidal disorder 17.11 10.58 3 110443 11265 46564351
Rib fracture 17.03 10.58 12 110434 18942 46556674
Illness 17.01 10.58 4 110442 12220 46563396
Photodermatosis 17.01 10.58 11 110435 386 46575230
Cataract 17.00 10.58 53 110393 45362 46530254
Necrosis 17.00 10.58 36 110410 4744 46570872
Bacterial translocation 16.98 10.58 9 110437 216 46575400
Serositis 16.94 10.58 13 110433 601 46575015
Upper limb fracture 16.89 10.58 8 110438 15705 46559911
Craniofacial deformity 16.88 10.58 7 110439 94 46575522
Hallucination 16.85 10.58 61 110385 49890 46525726
Optic neuropathy 16.81 10.58 21 110425 1775 46573841
Neuroleptic malignant syndrome 16.80 10.58 3 110443 11119 46564497
Product complaint 16.76 10.58 4 110442 12097 46563519
Blood iron decreased 16.75 10.58 3 110443 11094 46564522
Mycoplasma test positive 16.71 10.58 6 110440 53 46575563
Renal cortical necrosis 16.68 10.58 7 110439 97 46575519
Joint effusion 16.54 10.58 4 110442 11991 46563625
Continuous haemodiafiltration 16.54 10.58 16 110430 1015 46574601
Lung adenocarcinoma 16.53 10.58 33 110413 4171 46571445
Disseminated tuberculosis 16.51 10.58 26 110420 2726 46572890
Mesothelioma malignant 16.51 10.58 6 110440 55 46575561
Blood count abnormal 16.48 10.58 11 110435 17867 46557749
Urinary tract infection 16.44 10.58 657 109789 219609 46356007
Tinnitus 16.41 10.58 25 110421 27648 46547968
Arterial thrombosis 16.39 10.58 18 110428 1326 46574290
Mood swings 16.38 10.58 9 110437 16243 46559373
Haemothorax 16.34 10.58 22 110424 2002 46573614
Autoinflammatory disease 16.23 10.58 6 110440 58 46575558
Pleomorphism 16.17 10.58 4 110442 7 46575609
Blood pressure systolic increased 16.13 10.58 27 110419 28760 46546856
Surgery 16.13 10.58 27 110419 28758 46546858
Anal incontinence 16.10 10.58 4 110442 11774 46563842
Paraesthesia oral 16.09 10.58 4 110442 11769 46563847
Respiratory arrest 16.08 10.58 35 110411 33781 46541835
Gingivitis ulcerative 16.06 10.58 8 110438 168 46575448
Angina pectoris 16.06 10.58 24 110422 26751 46548865
Gastrointestinal necrosis 16.05 10.58 26 110420 2792 46572824
Bacterial colitis 16.05 10.58 6 110440 60 46575556
Infectious pleural effusion 16.00 10.58 16 110430 1057 46574559
Lip swelling 15.98 10.58 22 110424 25373 46550243
Urinary retention 15.98 10.58 23 110423 26038 46549578
Pupil fixed 15.92 10.58 20 110426 1700 46573916
Dermatitis allergic 15.89 10.58 5 110441 12598 46563018
Hyponatraemia 15.89 10.58 158 110288 101174 46474442
Herpes zoster 15.87 10.58 237 110209 67635 46507981
Parapox virus infection 15.82 10.58 4 110442 8 46575608
Electrocardiogram QT prolonged 15.82 10.58 65 110381 51260 46524356
Erythropoiesis abnormal 15.80 10.58 9 110437 250 46575366
Encephalomyelitis 15.78 10.58 7 110439 112 46575504
Cachexia 15.76 10.58 35 110411 4764 46570852
Systemic lupus erythematosus 15.76 10.58 90 110356 65090 46510526
Pneumonia haemophilus 15.75 10.58 12 110434 549 46575067
Pelvic pain 15.75 10.58 4 110442 11598 46564018
Body temperature decreased 15.73 10.58 6 110440 13403 46562213
Mycobacterium chelonae infection 15.73 10.58 11 110435 440 46575176
Vascular graft complication 15.73 10.58 5 110441 29 46575587
Blood pressure diastolic decreased 15.64 10.58 7 110439 14204 46561412
Nightmare 15.59 10.58 10 110436 16588 46559028
Drug trough level 15.59 10.58 5 110441 30 46575586
Dependence on respirator 15.59 10.58 5 110441 30 46575586
Campylobacter infection 15.53 10.58 13 110433 682 46574934
Biliary tract disorder 15.51 10.58 13 110433 683 46574933
Disseminated coccidioidomycosis 15.50 10.58 4 110442 9 46575607
Venous haemorrhage 15.48 10.58 8 110438 182 46575434
Asteatosis 15.38 10.58 6 110440 68 46575548
Mucosal necrosis 15.31 10.58 5 110441 32 46575584
Cytotoxic oedema 15.29 10.58 7 110439 121 46575495
Leiomyoma 15.18 10.58 10 110436 362 46575254
Cerebral ventricle collapse 15.18 10.58 5 110441 33 46575583
Purulent pericarditis 15.18 10.58 5 110441 33 46575583
Diarrhoea infectious 15.17 10.58 15 110431 977 46574639
Complications of transplanted pancreas 15.15 10.58 3 110443 0 46575616
Corynebacterium bacteraemia 15.15 10.58 3 110443 0 46575616
Hepatic cyst ruptured 15.15 10.58 3 110443 0 46575616
Mesenteric fibrosis 15.15 10.58 3 110443 0 46575616
Portal vein flow decreased 15.15 10.58 3 110443 0 46575616
Ureteric anastomosis complication 15.15 10.58 3 110443 0 46575616
Phaeohyphomycotic brain abscess 15.15 10.58 3 110443 0 46575616
Multiple organ transplant rejection 15.15 10.58 3 110443 0 46575616
Sarcoma metastatic 15.15 10.58 3 110443 0 46575616
Hepatic artery occlusion 15.15 10.58 3 110443 0 46575616
Jejunal ulcer perforation 15.06 10.58 5 110441 34 46575582
Dystonia 15.05 10.58 4 110442 11253 46564363
Leukaemia recurrent 15.05 10.58 17 110429 1292 46574324
Abnormal dreams 15.04 10.58 3 110443 10276 46565340
Skin induration 15.02 10.58 26 110420 2948 46572668
Arrhythmia 15.01 10.58 38 110408 34803 46540813
Haemorrhagic ovarian cyst 14.98 10.58 12 110434 591 46575025
Throat tightness 14.98 10.58 16 110430 20623 46554993
Pulmonary tuberculosis 14.97 10.58 34 110412 4697 46570919
Muscle twitching 14.97 10.58 8 110438 14664 46560952
Hepatic vein occlusion 14.93 10.58 6 110440 74 46575542
Inflammatory bowel disease 14.88 10.58 27 110419 3178 46572438
Chronic myeloid leukaemia recurrent 14.87 10.58 8 110438 198 46575418
Thyroid disorder 14.86 10.58 5 110441 12071 46563545
Septal panniculitis 14.86 10.58 6 110440 75 46575541
Neutrophilic panniculitis 14.81 10.58 5 110441 36 46575580
Renal salt-wasting syndrome 14.80 10.58 8 110438 200 46575416
Osteoporosis 14.77 10.58 48 110398 40560 46535056
Klebsiella bacteraemia 14.77 10.58 16 110430 1160 46574456
Tonsil cancer 14.73 10.58 8 110438 202 46575414
Urinary tract infection enterococcal 14.73 10.58 23 110423 2395 46573221
Blister 14.73 10.58 55 110391 44576 46531040
Wound infection fungal 14.71 10.58 6 110440 77 46575539
Palmar-plantar erythrodysaesthesia syndrome 14.68 10.58 16 110430 20435 46555181
Microgenia 14.68 10.58 4 110442 12 46575604
Dermatitis papillaris capillitii 14.68 10.58 4 110442 12 46575604
Apoptosis 14.65 10.58 6 110440 78 46575538
Immunosuppression 14.63 10.58 45 110401 7455 46568161
Abdominal wound dehiscence 14.62 10.58 8 110438 205 46575411
Dehydration 14.47 10.58 278 110168 159262 46416354
Epstein-Barr virus antigen positive 14.46 10.58 5 110441 39 46575577
Transient acantholytic dermatosis 14.46 10.58 5 110441 39 46575577
Morphoea 14.43 10.58 9 110437 296 46575320
Cold sweat 14.42 10.58 4 110442 10941 46564675
Ear infection 14.42 10.58 20 110426 22993 46552623
Acute hepatic failure 14.41 10.58 71 110375 14650 46560966
Hypoacusis 14.41 10.58 17 110429 20952 46554664
Reversible cerebral vasoconstriction syndrome 14.38 10.58 19 110427 1698 46573918
Hepatic enzyme increased 14.34 10.58 124 110322 81663 46493953
Hypervolaemia 14.33 10.58 19 110427 1703 46573913
Blood pressure decreased 14.32 10.58 78 110368 57081 46518535
Mucosal disorder 14.32 10.58 20 110426 1884 46573732
Exposure via partner 14.32 10.58 7 110439 141 46575475
Aortic rupture 14.31 10.58 6 110440 83 46575533
Corynebacterium infection 14.26 10.58 10 110436 402 46575214
Tooth abscess 14.26 10.58 6 110440 12627 46562989
Rhabdomyolysis 14.25 10.58 51 110395 41858 46533758
Norovirus test positive 14.23 10.58 7 110439 143 46575473
Superinfection viral 14.21 10.58 4 110442 14 46575602
Colorectal adenocarcinoma 14.18 10.58 6 110440 85 46575531
Ecthyma 14.18 10.58 8 110438 218 46575398
Respiratory tract infection fungal 14.15 10.58 10 110436 407 46575209
Obesity 14.13 10.58 8 110438 14198 46561418
Spinal stenosis 14.09 10.58 6 110440 12537 46563079
Urinary tract candidiasis 14.05 10.58 11 110435 524 46575092
Nephrectomy 14.05 10.58 11 110435 524 46575092
Nephrostomy 14.04 10.58 5 110441 43 46575573
Spinal osteoarthritis 14.03 10.58 8 110438 14143 46561473
Transaminases increased 14.01 10.58 113 110333 27648 46547968
Pancreatic abscess 14.00 10.58 4 110442 15 46575601
Hepatitis viral 13.98 10.58 10 110436 415 46575201
Gastric ulcer 13.89 10.58 94 110352 21769 46553847
Disorientation 13.88 10.58 43 110403 36875 46538741
Gallbladder rupture 13.81 10.58 10 110436 423 46575193
Blood culture positive 13.81 10.58 32 110414 4480 46571136
Small cell lung cancer recurrent 13.80 10.58 4 110442 16 46575600
Growth retardation 13.80 10.58 14 110432 941 46574675
Coarctation of the aorta 13.77 10.58 11 110435 540 46575076
Adenocarcinoma 13.76 10.58 22 110424 2337 46573279
Limbic encephalitis 13.73 10.58 8 110438 232 46575384
Oropharyngeal candidiasis 13.66 10.58 14 110432 952 46574664
Glomerulonephritis acute 13.65 10.58 5 110441 47 46575569
Acquired macroglossia 13.64 10.58 6 110440 94 46575522
Tooth infection 13.60 10.58 6 110440 12280 46563336
Protein-losing gastroenteropathy 13.60 10.58 7 110439 158 46575458
Pneumopericardium 13.56 10.58 5 110441 48 46575568
Cerebral haemorrhage 13.52 10.58 114 110332 28257 46547359
Jejunal ulcer 13.47 10.58 6 110440 97 46575519
Sarcopenia 13.46 10.58 5 110441 49 46575567
Brain herniation 13.44 10.58 25 110421 2998 46572618
Genital herpes simplex 13.44 10.58 7 110439 162 46575454
Herpes simplex viraemia 13.44 10.58 7 110439 162 46575454
Glomerulonephritis membranous 13.42 10.58 11 110435 560 46575056
Acute vestibular syndrome 13.42 10.58 4 110442 18 46575598
Dacryocystitis 13.42 10.58 4 110442 18 46575598
Autoimmune pancytopenia 13.41 10.58 6 110440 98 46575518
Deafness 13.38 10.58 11 110435 16057 46559559
Hirsutism 13.33 10.58 14 110432 980 46574636
Body temperature increased 13.31 10.58 24 110422 24837 46550779
Atrial septal defect 13.30 10.58 39 110407 6293 46569323
Hypocomplementaemia 13.29 10.58 7 110439 166 46575450
Hepatocellular carcinoma 13.28 10.58 24 110422 2815 46572801
Exposure via father 13.28 10.58 9 110437 342 46575274
Cholangitis acute 13.27 10.58 10 110436 450 46575166
Pneumonia cryptococcal 13.27 10.58 11 110435 569 46575047
Blood immunoglobulin M decreased 13.26 10.58 12 110434 699 46574917
Device related bacteraemia 13.24 10.58 4 110442 19 46575597
Renal glycosuria 13.24 10.58 4 110442 19 46575597
Head discomfort 13.24 10.58 4 110442 10347 46565269
Lung infiltration 13.23 10.58 67 110379 13976 46561640
Withdrawal syndrome 13.23 10.58 14 110432 18120 46557496
Renal cyst infection 13.19 10.58 6 110440 102 46575514
Aspergilloma 13.17 10.58 7 110439 169 46575447
Parvovirus B19 test positive 13.14 10.58 6 110440 103 46575513
Central nervous system lupus 13.12 10.58 5 110441 53 46575563
Cryptococcal cutaneous infection 13.12 10.58 5 110441 53 46575563
Clostridium difficile infection 13.11 10.58 103 110343 25000 46550616
Acute myeloid leukaemia (in remission) 13.08 10.58 3 110443 3 46575613
Pericarditis fungal 13.08 10.58 3 110443 3 46575613
Conjunctival neoplasm 13.08 10.58 3 110443 3 46575613
Skin squamous cell carcinoma recurrent 13.08 10.58 3 110443 3 46575613
Oliguria 13.05 10.58 48 110398 8711 46566905
Haemodialysis complication 12.97 10.58 8 110438 258 46575358
Pancreatitis acute 12.96 10.58 102 110344 24770 46550846
Hepatitis cholestatic 12.96 10.58 40 110406 6637 46568979
Abdominal compartment syndrome 12.93 10.58 11 110435 590 46575026
Hepatic amoebiasis 12.92 10.58 4 110442 21 46575595
Choriomeningitis lymphocytic 12.92 10.58 4 110442 21 46575595
Coronary artery disease 12.91 10.58 39 110407 33713 46541903
Drug level abnormal 12.79 10.58 5 110441 57 46575559
Bronchoalveolar lavage abnormal 12.78 10.58 6 110440 110 46575506
Drug dependence 12.77 10.58 17 110429 19884 46555732
Thyroid tuberculosis 12.76 10.58 4 110442 22 46575594
Coordination abnormal 12.68 10.58 5 110441 10944 46564672
Joint tuberculosis 12.64 10.58 6 110440 113 46575503
Cardiorenal syndrome 12.63 10.58 11 110435 609 46575007
Malignant anorectal neoplasm 12.61 10.58 4 110442 23 46575593
Hepatobiliary infection 12.61 10.58 4 110442 23 46575593
Calciphylaxis 12.59 10.58 22 110424 2513 46573103
Asterixis 12.50 10.58 15 110431 1216 46574400
Ocular hyperaemia 12.48 10.58 17 110429 19693 46555923
Mesangioproliferative glomerulonephritis 12.47 10.58 4 110442 24 46575592
Anastomotic haemorrhage 12.42 10.58 5 110441 62 46575554
Biopsy kidney 12.40 10.58 6 110440 118 46575498
Endothelial dysfunction 12.40 10.58 6 110440 118 46575498
Blast crisis in myelogenous leukaemia 12.39 10.58 10 110436 498 46575118
Pneumonia 12.36 10.58 1042 109404 375278 46200338
Mycobacterium kansasii infection 12.27 10.58 6 110440 121 46575495
Delirium 12.20 10.58 46 110400 37182 46538434
Cardiac valve vegetation 12.19 10.58 8 110438 288 46575328
Hypertensive emergency 12.18 10.58 17 110429 1601 46574015
Sinus congestion 12.18 10.58 8 110438 13101 46562515
Systemic inflammatory response syndrome 12.17 10.58 34 110412 5337 46570279
Eye disorder 12.15 10.58 15 110431 18126 46557490
Central nervous system vasculitis 12.13 10.58 13 110433 931 46574685
Retching 12.08 10.58 8 110438 13049 46562567
Stevens-Johnson syndrome 12.02 10.58 23 110423 23274 46552342
Paranoia 12.01 10.58 5 110441 10592 46565024
Febrile neutropenia 12.01 10.58 301 110145 94326 46481290
Dermatomyositis 12.00 10.58 19 110427 2002 46573614
Gestational diabetes 11.99 10.58 41 110405 7178 46568438
Lymphocytic infiltration 11.98 10.58 12 110434 794 46574822
Renal haemorrhage 11.98 10.58 12 110434 794 46574822
White blood cell count decreased 11.96 10.58 190 110256 112041 46463575
Corynebacterium sepsis 11.95 10.58 4 110442 28 46575588
Reticulocyte count decreased 11.88 10.58 9 110437 408 46575208
Vascular graft thrombosis 11.87 10.58 3 110443 6 46575610
Anion gap normal 11.87 10.58 3 110443 6 46575610
Meningitis aspergillus 11.87 10.58 3 110443 6 46575610
Hyperkalaemia 11.83 10.58 177 110269 50532 46525084
Encephalitis Japanese B 11.82 10.58 4 110442 29 46575587
Jarisch-Herxheimer reaction 11.80 10.58 8 110438 304 46575312
Type III immune complex mediated reaction 11.68 10.58 7 110439 214 46575402
Skin laceration 11.67 10.58 16 110430 18486 46557130
Maternal drugs affecting foetus 11.60 10.58 34 110412 5484 46570132
Middle insomnia 11.60 10.58 4 110442 9511 46566105
Nephrosclerosis 11.58 10.58 13 110433 981 46574635
Bronchiolitis 11.57 10.58 20 110426 2265 46573351
Herpes virus infection 11.56 10.58 31 110415 4751 46570865
Cervix carcinoma 11.56 10.58 22 110424 2685 46572931
Microsporum infection 11.55 10.58 3 110443 7 46575609
Rash erythematous 11.55 10.58 42 110404 34308 46541308
Hepatitis B reactivation 11.53 10.58 16 110430 1498 46574118
Insulin resistance 11.53 10.58 11 110435 686 46574930
Dyslipidaemia 11.52 10.58 34 110412 5506 46570110
Immunoglobulins decreased 11.50 10.58 12 110434 834 46574782
Neuroblastoma recurrent 11.48 10.58 4 110442 32 46575584
Listeriosis 11.47 10.58 14 110432 1155 46574461
Vitamin D deficiency 11.47 10.58 6 110440 11128 46564488
Sciatica 11.45 10.58 17 110429 19003 46556613
Anomaly of external ear congenital 11.44 10.58 6 110440 141 46575475
Acute myocardial infarction 11.43 10.58 38 110408 31886 46543730
Laboratory test abnormal 11.40 10.58 23 110423 22824 46552792
Agnosia 11.40 10.58 6 110440 142 46575474
Irritability 11.39 10.58 33 110413 28913 46546703
Blood creatine phosphokinase increased 11.36 10.58 31 110415 27693 46547923
Drug effective for unapproved indication 11.30 10.58 16 110430 1526 46574090
Anal ulcer 11.28 10.58 9 110437 441 46575175
Calcification of muscle 11.27 10.58 4 110442 34 46575582
Complications of intestinal transplant 11.27 10.58 3 110443 8 46575608
Hepatitis C virus test 11.27 10.58 3 110443 8 46575608
Feeding disorder 11.25 10.58 5 110441 10189 46565427
Mucocutaneous leishmaniasis 11.25 10.58 8 110438 329 46575287
Productive cough 11.22 10.58 72 110374 50643 46524973
Peripheral T-cell lymphoma unspecified 11.18 10.58 7 110439 232 46575384
Herpes simplex meningoencephalitis 11.17 10.58 4 110442 35 46575581
Salivary gland mass 11.16 10.58 5 110441 82 46575534
Metastases to bone 11.14 10.58 15 110431 17461 46558155
Sinusitis fungal 11.13 10.58 12 110434 866 46574750
Septic encephalopathy 11.10 10.58 5 110441 83 46575533
Lower respiratory tract infection fungal 11.10 10.58 7 110439 235 46575381
Abortion missed 11.07 10.58 16 110430 1556 46574060
Myopathy 11.06 10.58 46 110400 8835 46566781
Mental impairment 11.04 10.58 8 110438 12448 46563168
Cell marker increased 11.04 10.58 8 110438 339 46575277
Extranodal marginal zone B-cell lymphoma (MALT type) 11.03 10.58 9 110437 455 46575161
Acquired mitochondrial DNULL mutation 11.01 10.58 3 110443 9 46575607
Vaginal haemorrhage 10.97 10.58 28 110418 25576 46550040
Escherichia test positive 10.97 10.58 18 110428 1954 46573662
Toxic optic neuropathy 10.96 10.58 6 110440 154 46575462
Salmonellosis 10.96 10.58 12 110434 881 46574735
Abortion threatened 10.94 10.58 10 110436 590 46575026
Acinetobacter bacteraemia 10.94 10.58 5 110441 86 46575530
Parotitis 10.93 10.58 14 110432 1213 46574403
Renal infarct 10.93 10.58 14 110432 1213 46574403
Paroxysmal nocturnal haemoglobinuria 10.92 10.58 6 110440 155 46575461
Rhinorrhoea 10.89 10.58 67 110379 47598 46528018
Wound infection 10.89 10.58 51 110395 10308 46565308
Urinary tract infection fungal 10.89 10.58 10 110436 594 46575022
Herpes simplex meningitis 10.88 10.58 4 110442 38 46575578
Endophthalmitis 10.87 10.58 24 110422 3254 46572362
Cholangiocarcinoma 10.86 10.58 13 110433 1051 46574565
Fungaemia 10.84 10.58 18 110428 1973 46573643
Eye infection 10.84 10.58 4 110442 9119 46566497
Genitourinary tract infection 10.82 10.58 6 110440 158 46575458
Rash maculo-papular 10.81 10.58 32 110414 27842 46547774
Renal hypertension 10.79 10.58 4 110442 39 46575577
Catatonia 10.78 10.58 26 110420 3736 46571880
Night sweats 10.77 10.58 31 110415 27219 46548397
Picornavirus infection 10.77 10.58 3 110443 10 46575606
Leukaemia in remission 10.77 10.58 3 110443 10 46575606
Nasal septum ulceration 10.77 10.58 3 110443 10 46575606
Ventricular remodelling 10.77 10.58 3 110443 10 46575606
Pharyngeal necrosis 10.77 10.58 3 110443 10 46575606
Lymphocytopenia neonatal 10.77 10.58 3 110443 10 46575606
Pseudomonal sepsis 10.77 10.58 18 110428 1984 46573632
Small intestinal perforation 10.74 10.58 14 110432 1234 46574382
Tuberculosis gastrointestinal 10.73 10.58 8 110438 354 46575262
Meningitis viral 10.72 10.58 14 110432 1237 46574379
Zinc deficiency 10.70 10.58 4 110442 40 46575576
Peritoneal dialysis 10.69 10.58 8 110438 356 46575260
Ageusia 10.66 10.58 7 110439 11465 46564151
Multiple congenital abnormalities 10.65 10.58 9 110437 478 46575138
Endocarditis staphylococcal 10.63 10.58 8 110438 359 46575257
Peripheral coldness 10.62 10.58 5 110441 9850 46565766
Respiratory rate increased 10.59 10.58 7 110439 11426 46564190

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Transplant rejection 2342.28 11.08 1040 135754 8166 29807518
Cytomegalovirus infection 1723.85 11.08 1168 135626 22506 29793178
Kidney transplant rejection 1348.30 11.08 667 136127 6842 29808842
Polyomavirus-associated nephropathy 1348.11 11.08 518 136276 2667 29813017
Immunosuppressant drug level increased 1301.82 11.08 564 136230 4138 29811546
Post transplant lymphoproliferative disorder 1277.52 11.08 577 136217 4729 29810955
Thrombotic microangiopathy 1021.31 11.08 580 136214 8030 29807654
Product use in unapproved indication 1005.97 11.08 1448 135346 72245 29743439
Complications of transplanted kidney 952.55 11.08 435 136359 3666 29812018
Graft versus host disease 950.64 11.08 587 136207 9563 29806121
Liver transplant rejection 871.63 11.08 341 136453 1857 29813827
Acute graft versus host disease 866.96 11.08 457 136337 5407 29810277
BK virus infection 835.19 11.08 405 136389 3959 29811725
Nocardiosis 754.03 11.08 351 136443 3104 29812580
Cytomegalovirus viraemia 736.67 11.08 407 136387 5322 29810362
Transplant dysfunction 706.61 11.08 299 136495 2053 29813631
COVID-19 594.99 11.08 557 136237 17321 29798363
Epstein-Barr virus infection 560.62 11.08 361 136433 6345 29809339
Aspergillus infection 537.00 11.08 414 136380 9800 29805884
Chronic graft versus host disease 511.43 11.08 286 136508 3833 29811851
Drug level increased 491.78 11.08 508 136286 17846 29797838
Mucormycosis 491.45 11.08 304 136490 4964 29810720
Adenovirus infection 485.88 11.08 280 136514 3988 29811696
Transplant failure 477.93 11.08 232 136562 2272 29813412
Off label use 467.96 11.08 2310 134484 246980 29568704
Fatigue 454.91 11.08 478 136316 320195 29495489
Phaeohyphomycosis 426.27 11.08 155 136639 663 29815021
Graft versus host disease in skin 425.28 11.08 235 136559 3072 29812612
Immunosuppressant drug level decreased 418.36 11.08 172 136622 1087 29814597
Nephropathy toxic 409.92 11.08 360 136434 10279 29805405
Posterior reversible encephalopathy syndrome 404.16 11.08 328 136466 8379 29807305
Chronic allograft nephropathy 396.67 11.08 162 136632 1004 29814680
Bronchopulmonary aspergillosis 384.41 11.08 370 136424 11914 29803770
Fall 373.86 11.08 182 136612 181690 29633994
Kidney fibrosis 373.48 11.08 185 136609 1900 29813784
Completed suicide 369.51 11.08 21 136773 99471 29716213
Dizziness 368.53 11.08 217 136577 194692 29620992
Acute graft versus host disease in skin 355.14 11.08 234 136560 4282 29811402
Delayed graft function 342.70 11.08 165 136629 1584 29814100
Hepatitis E 332.06 11.08 158 136636 1474 29814210
Dyspnoea 318.46 11.08 654 136140 332641 29483043
Renal transplant failure 316.98 11.08 134 136660 917 29814767
Renal impairment 316.19 11.08 973 135821 83211 29732473
Focal segmental glomerulosclerosis 306.32 11.08 155 136639 1672 29814012
Renal tubular atrophy 299.13 11.08 129 136665 933 29814751
Enterococcal infection 290.51 11.08 265 136529 7959 29807725
Drug interaction 286.15 11.08 1720 135074 197848 29617836
Strongyloidiasis 280.67 11.08 159 136635 2187 29813497
Graft versus host disease in gastrointestinal tract 273.36 11.08 172 136622 2897 29812787
Cytomegalovirus test positive 267.66 11.08 181 136613 3464 29812220
Multiple organ dysfunction syndrome 264.08 11.08 761 136033 62726 29752958
Parvovirus B19 infection 263.84 11.08 99 136695 471 29815213
Heart transplant rejection 260.11 11.08 123 136671 1130 29814554
Death 247.85 11.08 823 135971 356460 29459224
Brain abscess 245.70 11.08 153 136641 2528 29813156
Myocardial infarction 244.11 11.08 135 136659 125490 29690194
Pain 241.04 11.08 260 136534 172381 29643303
Pneumocystis jirovecii pneumonia 236.71 11.08 339 136455 16781 29798903
Klebsiella infection 233.69 11.08 217 136577 6670 29809014
Cystitis haemorrhagic 232.04 11.08 185 136609 4602 29811082
Graft loss 229.80 11.08 101 136693 769 29814915
JC virus infection 229.60 11.08 127 136667 1663 29814021
Epstein-Barr virus associated lymphoproliferative disorder 225.49 11.08 124 136670 1604 29814080
Asthenia 224.01 11.08 419 136375 220871 29594813
Nausea 223.39 11.08 659 136135 296298 29519386
Cryptococcosis 223.35 11.08 125 136669 1677 29814007
Haemophagocytic lymphohistiocytosis 221.72 11.08 248 136546 9543 29806141
Constipation 212.65 11.08 126 136668 112780 29702904
Acute graft versus host disease in intestine 209.73 11.08 133 136661 2272 29813412
Blood creatinine increased 203.73 11.08 892 135902 90483 29725201
Pseudomonas infection 201.40 11.08 244 136550 10238 29805446
Rash 199.75 11.08 357 136437 191532 29624152
Lung transplant rejection 195.46 11.08 87 136707 685 29814999
Escherichia infection 194.85 11.08 190 136604 6215 29809469
Pneumonia cytomegaloviral 193.83 11.08 134 136660 2662 29813022
Renal tubular necrosis 193.48 11.08 290 136504 14961 29800723
Hepatitis C 189.22 11.08 266 136528 12939 29802745
Fungal infection 186.10 11.08 268 136526 13332 29802352
Septic shock 182.62 11.08 672 136122 62935 29752749
Anxiety 179.74 11.08 93 136701 89778 29725906
Lymphoproliferative disorder 176.59 11.08 118 136676 2212 29813472
Hypotension 176.55 11.08 411 136383 200154 29615530
Malignant neoplasm progression 175.06 11.08 56 136738 72231 29743453
Cytomegalovirus colitis 174.35 11.08 118 136676 2261 29813423
Syncope 171.07 11.08 87 136707 84816 29730868
Scedosporium infection 169.64 11.08 77 136717 638 29815046
Depression 168.73 11.08 102 136692 90335 29725349
Somnolence 168.49 11.08 118 136676 96645 29719039
Malaise 167.13 11.08 318 136476 166644 29649040
Arthralgia 166.60 11.08 226 136568 135565 29680119
Renal transplant 163.75 11.08 102 136692 1686 29813998
Neurotoxicity 163.43 11.08 248 136546 12934 29802750
Varicella zoster virus infection 162.73 11.08 90 136704 1178 29814506
Actinic keratosis 161.44 11.08 133 136661 3470 29812214
Pain in extremity 159.28 11.08 161 136633 110060 29705624
Leukopenia 158.40 11.08 590 136204 55569 29760115
Viraemia 157.70 11.08 86 136708 1093 29814591
Human polyomavirus infection 157.38 11.08 71 136723 579 29815105
Pruritus 157.18 11.08 185 136609 118019 29697665
Cryptosporidiosis infection 156.51 11.08 59 136735 285 29815399
Cardiac failure congestive 154.95 11.08 97 136697 84310 29731374
Progressive multifocal leukoencephalopathy 154.26 11.08 198 136596 8815 29806869
Drug hypersensitivity 154.07 11.08 60 136734 68459 29747225
Diffuse large B-cell lymphoma 153.04 11.08 184 136610 7657 29808027
Product dose omission issue 150.17 11.08 119 136675 91512 29724172
West Nile viral infection 149.82 11.08 67 136727 534 29815150
Infection reactivation 148.68 11.08 77 136717 875 29814809
Epstein-Barr viraemia 148.57 11.08 76 136718 840 29814844
Candida infection 145.66 11.08 256 136538 15106 29800578
Proteinuria 142.78 11.08 261 136533 15884 29799800
Post transplant distal limb syndrome 141.97 11.08 52 136742 228 29815456
Trichodysplasia spinulosa 140.98 11.08 49 136745 178 29815506
Dermatophytosis 139.32 11.08 49 136745 186 29815498
Hyperhidrosis 139.29 11.08 66 136728 67024 29748660
Complications of transplanted liver 138.11 11.08 49 136745 192 29815492
Hepatic artery thrombosis 137.83 11.08 50 136744 212 29815472
Squamous cell carcinoma 134.44 11.08 198 136596 10052 29805632
Acute kidney injury 133.92 11.08 1869 134925 271973 29543711
Polyomavirus viraemia 133.81 11.08 59 136735 453 29815231
Fungal skin infection 133.10 11.08 101 136693 2331 29813353
Back pain 130.64 11.08 166 136628 102430 29713254
Chronic graft versus host disease in skin 129.29 11.08 64 136730 656 29815028
Pneumatosis intestinalis 128.33 11.08 103 136691 2587 29813097
Chronic obstructive pulmonary disease 128.31 11.08 27 136767 46099 29769585
Respiratory failure 127.87 11.08 842 135952 99800 29715884
Neutrophil Pelger-Huet anomaly present 125.53 11.08 46 136748 202 29815482
Lymphocele 125.47 11.08 80 136714 1380 29814304
Feeling abnormal 125.45 11.08 51 136743 56705 29758979
Alternaria infection 125.03 11.08 49 136745 268 29815416
Chest pain 124.79 11.08 216 136578 117411 29698273
Intentional overdose 124.58 11.08 20 136774 41461 29774223
Human herpesvirus 6 infection 124.47 11.08 89 136705 1869 29813815
Renal graft infection 123.24 11.08 46 136748 215 29815469
Toxoplasmosis 122.91 11.08 70 136724 973 29814711
Disease recurrence 120.29 11.08 225 136569 13936 29801748
Renal tubular injury 119.10 11.08 58 136736 572 29815112
Encephalitis viral 118.93 11.08 72 136722 1128 29814556
Suicide attempt 118.93 11.08 14 136780 36683 29779001
Acute graft versus host disease in liver 118.55 11.08 73 136721 1181 29814503
Drug level fluctuating 116.33 11.08 52 136742 414 29815270
Mycobacterial infection 115.83 11.08 81 136713 1640 29814044
Disseminated cryptococcosis 114.30 11.08 66 136728 943 29814741
Acinetobacter infection 114.24 11.08 66 136728 944 29814740
Biliary anastomosis complication 113.48 11.08 36 136758 90 29815594
Trichophytosis 112.64 11.08 45 136749 261 29815423
Joint swelling 112.51 11.08 37 136757 46909 29768775
Graft versus host disease in lung 111.64 11.08 52 136742 460 29815224
COVID-19 pneumonia 111.45 11.08 120 136674 4420 29811264
Obliterative bronchiolitis 111.37 11.08 69 136725 1129 29814555
Human herpesvirus 8 infection 111.27 11.08 57 136737 632 29815052
Peripheral swelling 110.94 11.08 71 136723 61003 29754681
Pulmonary nocardiosis 110.84 11.08 48 136746 351 29815333
Insomnia 109.75 11.08 160 136634 93176 29722508
Urticaria 108.39 11.08 57 136737 54549 29761135
Tubulointerstitial nephritis 108.05 11.08 247 136547 17644 29798040
Histoplasmosis 107.87 11.08 69 136725 1197 29814487
Pancreas transplant rejection 107.68 11.08 38 136756 146 29815538
Suicidal ideation 107.14 11.08 18 136776 36096 29779588
Drug level decreased 106.44 11.08 132 136662 5673 29810011
Meningitis cryptococcal 106.25 11.08 82 136712 1942 29813742
Injection site pain 104.89 11.08 9 136785 30301 29785383
Aplasia pure red cell 104.88 11.08 129 136665 5497 29810187
Loss of consciousness 104.62 11.08 125 136669 79250 29736434
Diabetes mellitus 104.28 11.08 423 136371 41442 29774242
Malacoplakia 103.96 11.08 34 136760 97 29815587
International normalised ratio increased 103.72 11.08 44 136750 47695 29767989
Hypoglycaemia 103 11.08 52 136742 50929 29764755
Haemolytic uraemic syndrome 102.68 11.08 80 136714 1922 29813762
Cytomegalovirus infection reactivation 102.29 11.08 75 136719 1640 29814044
Pyelonephritis 102.10 11.08 125 136669 5301 29810383
Venoocclusive liver disease 101.92 11.08 138 136656 6475 29809209
Stenotrophomonas infection 101.36 11.08 73 136721 1551 29814133
IgA nephropathy 101.26 11.08 60 136734 902 29814782
Hypersensitivity 100.63 11.08 61 136733 53967 29761717
Cerebrovascular accident 100.21 11.08 141 136653 83336 29732348
Complications of transplant surgery 98.86 11.08 48 136746 470 29815214
Neuropathy peripheral 98.30 11.08 106 136688 70369 29745315
Gastroenteritis norovirus 97.78 11.08 68 136726 1364 29814320
Osmotic demyelination syndrome 97.22 11.08 52 136742 634 29815050
Decreased appetite 95.57 11.08 357 136437 149553 29666131
Staphylococcal infection 94.92 11.08 329 136465 29895 29785789
Liver transplant 94.49 11.08 88 136706 2714 29812970
Epistaxis 94.31 11.08 63 136731 52918 29762766
Angiosarcoma 93.64 11.08 38 136756 231 29815453
Mycobacterium abscessus infection 93.09 11.08 48 136746 540 29815144
Rheumatoid arthritis 92.70 11.08 36 136758 41161 29774523
Bradycardia 92.01 11.08 98 136696 65428 29750256
Blastomycosis 90.38 11.08 38 136756 256 29815428
Nephrotic syndrome 90.29 11.08 133 136661 6752 29808932
Ureteric stenosis 90.07 11.08 61 136733 1170 29814514
Atrial fibrillation 89.87 11.08 228 136566 107896 29707788
Complications of transplanted heart 89.66 11.08 36 136758 212 29815472
Pneumonia cryptococcal 88.99 11.08 50 136744 676 29815008
Acute respiratory distress syndrome 88.56 11.08 272 136522 23200 29792484
Encephalitis 88.28 11.08 127 136667 6309 29809375
Skin papilloma 88.23 11.08 68 136726 1607 29814077
Blood creatine phosphokinase increased 86.68 11.08 46 136748 43802 29771882
Rhabdomyolysis 86.06 11.08 98 136696 63482 29752202
Malacoplakia gastrointestinal 84.01 11.08 26 136768 58 29815626
Food allergy 83.66 11.08 52 136742 856 29814828
Pneumocystis jirovecii infection 82.90 11.08 60 136734 1285 29814399
Drug reaction with eosinophilia and systemic symptoms 82.75 11.08 15 136779 28473 29787211
Nasopharyngitis 82.63 11.08 88 136706 58761 29756923
Plasma cell myeloma 81.93 11.08 74 136720 53388 29762296
Papilloma viral infection 81.31 11.08 38 136756 339 29815345
Renal tubular acidosis 81.09 11.08 67 136727 1755 29813929
Complications of transplanted lung 80.56 11.08 31 136763 160 29815524
Acute myocardial infarction 80.27 11.08 74 136720 52865 29762819
Pneumonia fungal 80.05 11.08 112 136682 5421 29810263
Glomerulonephritis membranoproliferative 79.53 11.08 38 136756 358 29815326
Blood pressure increased 78.13 11.08 130 136664 71798 29743886
Infusion related reaction 78.08 11.08 44 136750 40520 29775164
Ascites 77.88 11.08 348 136446 35573 29780111
Pyelonephritis acute 76.00 11.08 61 136733 1532 29814152
Adenoviral haemorrhagic cystitis 75.72 11.08 38 136756 402 29815282
Encapsulating peritoneal sclerosis 74.98 11.08 43 136751 606 29815078
Lymphopenia 74.30 11.08 177 136617 12986 29802698
Gait disturbance 74.17 11.08 143 136651 74634 29741050
Bile duct stenosis 73.79 11.08 54 136740 1177 29814507
Post procedural bile leak 73.46 11.08 34 136760 296 29815388
Muscle spasms 73.42 11.08 114 136680 64724 29750960
Chronic graft versus host disease in liver 72.54 11.08 32 136762 246 29815438
Eczema herpeticum 72.10 11.08 25 136769 90 29815594
Acanthamoeba infection 72.08 11.08 38 136756 449 29815235
Musculoskeletal stiffness 71.87 11.08 37 136757 35844 29779840
Pancytopenia 71.79 11.08 647 136147 84405 29731279
Graft versus host disease in liver 71.76 11.08 49 136745 953 29814731
Pneumonia klebsiella 71.70 11.08 73 136721 2517 29813167
Unevaluable event 71.14 11.08 28 136766 31757 29783927
Aggression 71.08 11.08 40 136754 36867 29778817
Balance disorder 71.08 11.08 39 136755 36454 29779230
Angioedema 71.07 11.08 34 136760 34350 29781334
Hypoaesthesia 70.80 11.08 86 136708 54144 29761540
Non-cirrhotic portal hypertension 70.75 11.08 31 136763 234 29815450
Meningoencephalitis herpetic 70.28 11.08 44 136750 734 29814950
Histology abnormal 70.20 11.08 32 136762 268 29815416
Enterobacter infection 69.89 11.08 65 136729 2001 29813683
Hydronephrosis 69.25 11.08 137 136657 8846 29806838
Glomerulonephritis 69.11 11.08 61 136733 1752 29813932
Cerebral aspergillosis 69.07 11.08 54 136740 1304 29814380
Weight increased 68.58 11.08 150 136644 74763 29740921
Kaposi's sarcoma 68.29 11.08 48 136746 980 29814704
Hepatic fibrosis 68.21 11.08 83 136711 3497 29812187
Coronary artery disease 67.95 11.08 76 136718 49636 29766048
Erythema infectiosum 67.81 11.08 27 136767 155 29815529
Cardio-respiratory arrest 67.55 11.08 98 136696 57208 29758476
Graft complication 67.45 11.08 33 136761 329 29815355
Alveolar proteinosis 67.16 11.08 31 136763 268 29815416
Rectal haemorrhage 67.10 11.08 38 136756 34901 29780783
Mycobacterium chelonae infection 67.01 11.08 39 136755 566 29815118
Cardiac disorder 66.32 11.08 51 136743 39842 29775842
Lung transplant 66.21 11.08 61 136733 1855 29813829
Platelet count decreased 66.11 11.08 255 136539 105874 29709810
Dysgeusia 65.99 11.08 16 136778 24785 29790899
Squamous cell carcinoma of skin 65.69 11.08 135 136659 8960 29806724
Heart rate decreased 65.62 11.08 9 136785 20985 29794699
Pulmonary embolism 65.48 11.08 164 136630 77971 29737713
Meningitis viral 65.43 11.08 41 136753 685 29814999
Drug dependence 64.54 11.08 10 136784 21285 29794399
Pneumonia pseudomonal 64.50 11.08 80 136714 3438 29812246
Rhodococcus infection 64.49 11.08 26 136768 155 29815529
Ileal ulcer 63.39 11.08 37 136757 540 29815144
Paraesthesia 62.97 11.08 94 136700 54233 29761451
Bacterial sepsis 62.93 11.08 94 136700 4832 29810852
Large intestinal ulcer 62.82 11.08 56 136738 1630 29814054
Urinoma 62.75 11.08 27 136767 194 29815490
Intestine transplant rejection 62.71 11.08 18 136776 27 29815657
Haemodialysis 62.61 11.08 149 136645 10924 29804760
Choroiditis 62.58 11.08 42 136752 793 29814891
Periostitis 62.41 11.08 28 136766 225 29815459
Organising pneumonia 62.23 11.08 95 136699 4979 29810705
Hepatic artery stenosis 61.88 11.08 24 136770 127 29815557
Asthma 61.74 11.08 45 136749 36129 29779555
Chronic hepatitis 61.65 11.08 37 136757 570 29815114
Transplantation associated food allergy 61.61 11.08 15 136779 5 29815679
Nodular regenerative hyperplasia 61.54 11.08 40 136754 714 29814970
Hepatic cancer recurrent 61.20 11.08 31 136763 335 29815349
Cerebral toxoplasmosis 61.11 11.08 52 136742 1420 29814264
Herpes simplex 61.10 11.08 88 136706 4376 29811308
Sepsis 61.01 11.08 973 135821 145422 29670262
Osteomyelitis fungal 60.64 11.08 26 136768 185 29815499
Human herpesvirus 6 encephalitis 60.54 11.08 24 136770 136 29815548
Epstein-Barr virus test positive 60.37 11.08 35 136759 504 29815180
Cytomegalovirus enterocolitis 59.97 11.08 41 136753 799 29814885
Contraindicated product administered 59.93 11.08 5 136789 17226 29798458
Smooth muscle cell neoplasm 59.05 11.08 21 136773 83 29815601
Cytomegalovirus nephritis 58.91 11.08 22 136772 103 29815581
Pathogen resistance 58.59 11.08 123 136671 8287 29807397
Inappropriate schedule of product administration 58.50 11.08 57 136737 39671 29776013
Cytomegalovirus enteritis 58.31 11.08 31 136763 373 29815311
Pericarditis fungal 57.29 11.08 24 136770 160 29815524
Bacterial pyelonephritis 57.28 11.08 27 136767 246 29815438
Acute myeloid leukaemia recurrent 56.74 11.08 51 136743 1501 29814183
Vomiting 56.69 11.08 687 136107 219131 29596553
Cholangitis 56.58 11.08 116 136678 7686 29807998
Gastrooesophageal reflux disease 56.52 11.08 39 136755 32216 29783468
Polyomavirus test positive 56.46 11.08 21 136773 97 29815587
Disease progression 56.36 11.08 182 136612 79692 29735992
Wheezing 56.11 11.08 36 136758 30902 29784782
Central nervous system lymphoma 55.94 11.08 40 136754 840 29814844
Liver transplant failure 55.85 11.08 20 136774 81 29815603
Endophthalmitis 55.73 11.08 74 136720 3406 29812278
Agitation 55.73 11.08 101 136693 53972 29761712
Engraftment syndrome 55.58 11.08 39 136755 794 29814890
Overdose 55.55 11.08 198 136596 84139 29731545
Biliary tract disorder 55.49 11.08 39 136755 796 29814888
Coronavirus infection 55.43 11.08 74 136720 3424 29812260
Myalgia 55.28 11.08 173 136621 76494 29739190
Donor specific antibody present 55.28 11.08 20 136774 84 29815600
Dermoid cyst 54.96 11.08 21 136773 106 29815578
Histoplasmosis disseminated 54.89 11.08 41 136753 923 29814761
Headache 54.84 11.08 550 136244 181756 29633928
Dehydration 54.77 11.08 335 136459 123204 29692480
Hypogammaglobulinaemia 54.34 11.08 91 136703 5161 29810523
Blood pressure decreased 54.02 11.08 82 136712 46993 29768691
Anogenital warts 54.01 11.08 32 136762 481 29815203
Mobility decreased 53.28 11.08 26 136768 25973 29789711
Glomerulonephritis proliferative 52.96 11.08 24 136770 198 29815486
Clostridium difficile colitis 52.93 11.08 153 136641 12615 29803069
Cardiac failure 52.86 11.08 199 136595 83219 29732465
Wrong technique in product usage process 52.85 11.08 39 136755 31116 29784568
Glomerulosclerosis 52.79 11.08 35 136759 647 29815037
Abdominal discomfort 52.21 11.08 89 136705 48702 29766982
Drug resistance 52.17 11.08 206 136588 19927 29795757
Viral haemorrhagic cystitis 52.14 11.08 38 136756 823 29814861
End stage renal disease 52.10 11.08 109 136685 7326 29808358
Respiratory arrest 51.77 11.08 35 136759 29223 29786461
Oedema peripheral 51.73 11.08 278 136516 105554 29710130
Skin necrosis 51.73 11.08 84 136710 4643 29811041
Cytomegalovirus gastritis 51.57 11.08 23 136771 182 29815502
Dermatitis atopic 51.30 11.08 41 136753 1023 29814661
Hallucination 51.13 11.08 91 136703 48968 29766716
Drug level below therapeutic 51.08 11.08 70 136724 3322 29812362
Gastroenteritis sapovirus 50.94 11.08 20 136774 110 29815574
Memory impairment 50.61 11.08 57 136737 37117 29778567
Wound dehiscence 50.39 11.08 69 136725 3272 29812412
Urinary tract infection bacterial 50.37 11.08 47 136747 1453 29814231
Atypical mycobacterial infection 50.10 11.08 36 136758 762 29814922
Urinary fistula 50.06 11.08 20 136774 116 29815568
Heart rate increased 49.91 11.08 62 136732 38659 29777025
Presyncope 49.90 11.08 7 136787 16049 29799635
Disseminated mucormycosis 49.88 11.08 21 136773 142 29815542
Confusional state 49.70 11.08 386 136408 134448 29681236
Chest discomfort 49.55 11.08 82 136712 45398 29770286
Contusion 49.48 11.08 42 136752 31238 29784446
Drug level above therapeutic 49.40 11.08 64 136730 2875 29812809
Renal artery stenosis 49.40 11.08 51 136743 1788 29813896
Therapeutic product effect incomplete 49.29 11.08 49 136745 33785 29781899
Erythema 48.92 11.08 185 136609 77266 29738418
Tremor 48.90 11.08 543 136251 74820 29740864
Encephalopathy 48.71 11.08 282 136512 31923 29783761
General physical health deterioration 48.59 11.08 263 136531 99681 29716003
Therapeutic product effect decreased 48.54 11.08 37 136757 29039 29786645
Prophylaxis against transplant rejection 48.39 11.08 14 136780 22 29815662
Emphysematous pyelonephritis 48.30 11.08 15 136779 34 29815650
Pulmonary mucormycosis 47.83 11.08 28 136766 411 29815273
Oxygen saturation decreased 47.63 11.08 78 136716 43362 29772322
Dysplastic naevus 47.43 11.08 26 136768 334 29815350
Diaphragmatic hernia 47.25 11.08 24 136770 261 29815423
Portal vein thrombosis 46.99 11.08 68 136726 3396 29812288
Gingival hypertrophy 46.98 11.08 47 136747 1586 29814098
Systemic mycosis 46.52 11.08 41 136753 1175 29814509
Loss of personal independence in daily activities 46.52 11.08 20 136774 21515 29794169
Oliguria 46.35 11.08 104 136690 7335 29808349
Flushing 46.16 11.08 40 136754 29452 29786232
White blood cell count decreased 45.89 11.08 212 136582 83735 29731949
Heartland virus infection 45.49 11.08 12 136782 10 29815674
Upper gastrointestinal haemorrhage 45.18 11.08 22 136772 22006 29793678
Dry mouth 45.11 11.08 24 136770 22826 29792858
Sleep disorder 45.06 11.08 28 136766 24451 29791233
Escherichia urinary tract infection 44.90 11.08 61 136733 2871 29812813
Sedation 44.67 11.08 10 136784 16363 29799321
Burkholderia cepacia complex infection 44.66 11.08 20 136774 160 29815524
Transplantation complication 44.46 11.08 17 136777 86 29815598
Full blood count decreased 44.11 11.08 9 136785 15708 29799976
Neutrophil count decreased 44.01 11.08 79 136715 42375 29773309
Cutaneous malacoplakia 43.85 11.08 14 136780 36 29815648
Arthropathy 43.59 11.08 20 136774 20707 29794977
Drug withdrawal syndrome 43.42 11.08 18 136776 19791 29795893
Disseminated varicella zoster virus infection 43.41 11.08 36 136758 948 29814736
Microangiopathy 43.28 11.08 33 136761 767 29814917
Injection site erythema 43.07 11.08 6 136788 13828 29801856
Choriomeningitis lymphocytic 43.06 11.08 12 136782 15 29815669
Enterococcal bacteraemia 43.05 11.08 42 136752 1374 29814310
Thyroid gland abscess 42.84 11.08 15 136779 56 29815628
Liver abscess 42.75 11.08 63 136731 3199 29812485
C3 glomerulopathy 42.31 11.08 13 136781 28 29815656
Idiopathic pneumonia syndrome 42.27 11.08 21 136773 217 29815467
Flatulence 42.19 11.08 15 136779 18114 29797570
Superinfection bacterial 42.18 11.08 27 136767 469 29815215
Transient ischaemic attack 42.16 11.08 32 136762 25168 29790516
Biloma 41.99 11.08 16 136778 80 29815604
Bacterial infection 41.98 11.08 140 136654 12470 29803214
Anastomotic stenosis 41.95 11.08 22 136772 257 29815427
Intentional self-injury 41.82 11.08 6 136788 13526 29802158
Granuloma 41.63 11.08 53 136741 2339 29813345
Blood pressure fluctuation 41.56 11.08 14 136780 17489 29798195
Tularaemia 41.52 11.08 16 136778 83 29815601
Anaphylactic reaction 41.36 11.08 40 136754 27942 29787742
Cytomegalovirus gastroenteritis 41.35 11.08 20 136774 194 29815490
Serotonin syndrome 41.30 11.08 15 136779 17876 29797808
Perinephric collection 41.29 11.08 19 136775 163 29815521
Atypical mycobacterial pneumonia 41.27 11.08 17 136777 108 29815576
Lactic acidosis 41.26 11.08 49 136745 31164 29784520
Toxic optic neuropathy 41.07 11.08 30 136764 652 29815032
Palpitations 40.96 11.08 56 136738 33517 29782167
Demodicidosis 40.95 11.08 18 136776 137 29815547
Dry skin 40.89 11.08 26 136768 22428 29793256
Necrotising oesophagitis 40.89 11.08 25 136769 399 29815285
Capillaritis 40.88 11.08 17 136777 111 29815573
Graft versus host disease in eye 40.83 11.08 20 136774 200 29815484
Osteonecrosis of jaw 40.68 11.08 17 136777 18601 29797083
Solar lentigo 40.55 11.08 23 136771 317 29815367
Central nervous system lesion 40.47 11.08 77 136717 4829 29810855
Haematemesis 40.45 11.08 36 136758 26167 29789517
Ventricular remodelling 40.20 11.08 15 136779 70 29815614
Infectious thyroiditis 40.16 11.08 16 136778 92 29815592
Herpes zoster meningoencephalitis 40.07 11.08 21 136773 245 29815439
Neck pain 39.89 11.08 23 136771 20921 29794763
Fungaemia 39.73 11.08 50 136744 2181 29813503
Microsporidia infection 39.65 11.08 28 136766 576 29815108
Biopsy kidney abnormal 39.46 11.08 16 136778 97 29815587
Swelling face 39.38 11.08 24 136770 21180 29794504
Cholangitis sclerosing 39.22 11.08 33 136761 887 29814797
Neuroendocrine carcinoma of the skin 39.20 11.08 28 136766 587 29815097
Chronic graft versus host disease in intestine 39.18 11.08 20 136774 220 29815464
Post procedural urine leak 38.96 11.08 18 136776 156 29815528
Corynebacterium infection 38.88 11.08 24 136770 390 29815294
Stress 38.86 11.08 22 136772 20213 29795471
Disseminated intravascular coagulation 38.80 11.08 202 136592 21969 29793715
Weight decreased 38.72 11.08 472 136322 150449 29665235
Bacillary angiomatosis 38.66 11.08 14 136780 59 29815625
Mycoplasma infection 38.57 11.08 21 136773 266 29815418
Hypokalaemia 38.51 11.08 110 136684 50082 29765602
Cytomegalovirus chorioretinitis 38.41 11.08 60 136734 3208 29812476
Blood potassium decreased 38.41 11.08 14 136780 16648 29799036
Herpes simplex hepatitis 38.28 11.08 15 136779 82 29815602
Inferior vena cava stenosis 38.13 11.08 11 136783 17 29815667
Cholestasis 38.07 11.08 219 136575 24731 29790953
Klebsiella sepsis 38.02 11.08 43 136751 1674 29814010
Prostatic specific antigen increased 37.86 11.08 5 136789 11999 29803685
Scleroderma 37.83 11.08 38 136756 1289 29814395
Photodermatosis 37.79 11.08 24 136770 411 29815273
Hepatocellular carcinoma 37.77 11.08 113 136681 9497 29806187
Bacteraemia 37.75 11.08 156 136638 15404 29800280
Optic neuropathy 37.72 11.08 42 136752 1607 29814077
Immune reconstitution inflammatory syndrome 37.67 11.08 109 136685 8992 29806692
Erectile dysfunction 37.25 11.08 18 136776 18084 29797600
Chronic hepatitis C 37.11 11.08 25 136769 475 29815209
Cytomegalovirus hepatitis 36.99 11.08 21 136773 290 29815394
Granulomatous dermatitis 36.91 11.08 19 136775 213 29815471
Venoocclusive disease 36.83 11.08 52 136742 2538 29813146
Infection in an immunocompromised host 36.83 11.08 28 136766 648 29815036
Dysphagia 36.73 11.08 134 136660 56564 29759120
Peritonitis pneumococcal 36.68 11.08 11 136783 21 29815663
Oxalosis 36.68 11.08 11 136783 21 29815663
Osteoarthritis 36.62 11.08 19 136775 18330 29797354
Opportunistic infection 36.54 11.08 37 136757 1267 29814417
Vision blurred 36.41 11.08 86 136708 41730 29773954
Hot flush 36.17 11.08 11 136783 14669 29801015
Muir-Torre syndrome 36.11 11.08 10 136784 12 29815672
Disseminated Bacillus Calmette-Guerin infection 36.06 11.08 15 136779 98 29815586
Neurological symptom 36.03 11.08 60 136734 3387 29812297
Pleocytosis 36.00 11.08 24 136770 448 29815236
Enterococcal sepsis 35.97 11.08 40 136754 1528 29814156
H1N1 influenza 35.88 11.08 32 136762 932 29814752
Injury 35.83 11.08 28 136766 21703 29793981
Meningoencephalitis viral 35.68 11.08 15 136779 101 29815583
Drug ineffective for unapproved indication 35.51 11.08 120 136674 10760 29804924
Trichosporon infection 35.47 11.08 27 136767 626 29815058
Fear 35.39 11.08 4 136790 10821 29804863
Subcapsular renal haematoma 35.35 11.08 22 136772 363 29815321
Herpes zoster cutaneous disseminated 35.32 11.08 17 136777 163 29815521
Central nervous system infection 35.27 11.08 24 136770 464 29815220
Steroid diabetes 35.27 11.08 36 136758 1245 29814439
Nephropathy 35.19 11.08 77 136717 5339 29810345
Purtscher retinopathy 35.15 11.08 8 136786 0 29815684
Chronic kidney disease 35.09 11.08 294 136500 37544 29778140
Ureteral necrosis 35.09 11.08 12 136782 41 29815643
Emotional distress 35.09 11.08 14 136780 15751 29799933
Oesophageal achalasia 34.99 11.08 20 136774 280 29815404
Psoriasis 34.98 11.08 90 136704 42416 29773268
Renal failure 34.73 11.08 802 135992 128164 29687520
Intentional product misuse 34.61 11.08 66 136728 34601 29781083
Urinary tract infection enterococcal 34.45 11.08 30 136764 846 29814838
Musculoskeletal pain 34.43 11.08 55 136739 30885 29784799
Angina pectoris 34.26 11.08 51 136743 29467 29786217
Eye abscess 34.21 11.08 16 136778 143 29815541
Anger 34.20 11.08 5 136789 11115 29804569
Abnormal behaviour 34.10 11.08 40 136754 25583 29790101
Irritability 34.01 11.08 33 136761 23017 29792667
Enteritis 33.94 11.08 86 136708 6559 29809125
Anuria 33.87 11.08 114 136680 10202 29805482
Autoimmune haemolytic anaemia 33.85 11.08 64 136730 3995 29811689
Cystitis viral 33.83 11.08 23 136771 444 29815240
Toxic epidermal necrolysis 33.74 11.08 20 136774 17920 29797764
Pancreas transplant 33.73 11.08 11 136783 31 29815653
Chills 33.70 11.08 193 136601 72145 29743539
Stem cell transplant 33.64 11.08 45 136749 2086 29813598
Thrombosis 33.55 11.08 91 136703 42140 29773544
Hyperkalaemia 33.44 11.08 454 136340 65556 29750128
Diabetic cardiomyopathy 33.38 11.08 10 136784 19 29815665
Prostatitis 33.29 11.08 71 136723 4836 29810848
Cerebral fungal infection 33.22 11.08 17 136777 188 29815496
Fusarium infection 33.18 11.08 32 136762 1032 29814652
Nasal congestion 33.13 11.08 22 136772 18544 29797140
Arteritis infective 33.04 11.08 10 136784 20 29815664
Mycobacterium haemophilum infection 33.04 11.08 10 136784 20 29815664
BK polyomavirus test positive 33.04 11.08 10 136784 20 29815664
Mycetoma mycotic 32.99 11.08 11 136783 34 29815650
Renal lymphocele 32.87 11.08 12 136782 52 29815632
Cytomegalovirus oesophagitis 32.85 11.08 18 136776 231 29815453
American trypanosomiasis 32.76 11.08 17 136777 194 29815490
Intestinal tuberculosis 32.74 11.08 13 136781 74 29815610
Aspergilloma 32.72 11.08 20 136774 319 29815365
Guillain-Barre syndrome 32.72 11.08 72 136722 5011 29810673
Vascular hyalinosis 32.72 11.08 10 136784 21 29815663
Labelled drug-drug interaction medication error 32.45 11.08 114 136680 10424 29805260
Heart rate irregular 32.43 11.08 8 136786 12251 29803433
Nephritis haemorrhagic 32.41 11.08 9 136785 11 29815673
Orthostatic hypotension 32.38 11.08 37 136757 23942 29791742
Candida sepsis 32.30 11.08 32 136762 1067 29814617
Skin exfoliation 32.12 11.08 35 136759 23137 29792547
Graft thrombosis 32.10 11.08 19 136775 285 29815399
Engraft failure 32.08 11.08 22 136772 431 29815253
Laboratory test abnormal 32.03 11.08 20 136774 17422 29798262
Psoriatic arthropathy 31.93 11.08 16 136778 15745 29799939
Nightmare 31.71 11.08 8 136786 12068 29803616
Serum sickness 31.69 11.08 40 136754 1750 29813934
Pneumomediastinum 31.67 11.08 40 136754 1751 29813933
Varicella 31.66 11.08 37 136757 1493 29814191
Viral test positive 31.66 11.08 17 136777 209 29815475
Lethargy 31.51 11.08 85 136709 39434 29776250
Systemic candida 31.45 11.08 50 136744 2714 29812970
Swelling 31.31 11.08 74 136720 35901 29779783
Transitional cell carcinoma 31.30 11.08 42 136752 1953 29813731
Bone marrow transplant rejection 31.26 11.08 16 136778 177 29815507
Glomerulonephritis membranous 31.23 11.08 31 136763 1036 29814648
Acanthoma 30.98 11.08 10 136784 27 29815657
Dyspepsia 30.93 11.08 57 136737 30272 29785412
Gastroenteritis adenovirus 30.87 11.08 13 136781 88 29815596
Oral hairy leukoplakia 30.75 11.08 7 136787 0 29815684
Gastroenteritis cryptosporidial 30.65 11.08 16 136778 185 29815499
Subdural haematoma 30.59 11.08 25 136769 18947 29796737
Skin laceration 30.44 11.08 7 136787 11244 29804440
Orf 30.42 11.08 9 136785 16 29815668
Hepatic vein occlusion 30.34 11.08 14 136780 121 29815563
Abdominal wall abscess 30.32 11.08 22 136772 473 29815211
Tinnitus 30.17 11.08 18 136776 16070 29799614
Chemical peritonitis 30.14 11.08 14 136780 123 29815561
Seroma 30.09 11.08 24 136770 597 29815087
Renal tubular disorder 30.09 11.08 69 136725 4937 29810747
Faeces discoloured 30.04 11.08 13 136781 13933 29801751
Fungal endocarditis 29.78 11.08 15 136779 160 29815524
Oropharyngeal pain 29.55 11.08 53 136741 28443 29787241
Schistosomiasis 29.54 11.08 11 136783 51 29815633
Ecthyma 29.53 11.08 19 136775 333 29815351
Mycobacterium marinum infection 29.43 11.08 17 136777 243 29815441
Road traffic accident 29.43 11.08 21 136773 17050 29798634
Mycobacterium avium complex infection 29.43 11.08 48 136746 2663 29813021
Portal vein occlusion 29.43 11.08 12 136782 74 29815610
Incorrect dose administered 29.34 11.08 63 136731 31623 29784061
Primary effusion lymphoma 29.27 11.08 10 136784 34 29815650
Gastrointestinal haemorrhage 29.27 11.08 242 136552 83204 29732480
Tachycardia 29.09 11.08 207 136587 73532 29742152
Parvovirus infection 28.96 11.08 21 136773 451 29815233
Locked-in syndrome 28.95 11.08 17 136777 251 29815433
Staphylococcal bacteraemia 28.92 11.08 82 136712 6686 29808998
Necrotising retinitis 28.85 11.08 25 136769 700 29814984
Reactive gastropathy 28.84 11.08 15 136779 172 29815512
Hyponatraemia 28.83 11.08 184 136610 67018 29748666
Cutaneous T-cell lymphoma 28.83 11.08 33 136761 1302 29814382
Angiosarcoma metastatic 28.80 11.08 9 136785 21 29815663
Rib fracture 28.80 11.08 11 136783 12709 29802975
Skin lesion 28.65 11.08 163 136631 18331 29797353
Dehiscence 28.55 11.08 11 136783 57 29815627
Injection site reaction 28.51 11.08 7 136787 10753 29804931
Chronic myeloid leukaemia 28.48 11.08 46 136748 2531 29813153
Emphysematous cystitis 28.42 11.08 10 136784 38 29815646
Drug eruption 28.37 11.08 23 136771 17503 29798181
Hepatic vein stenosis 28.28 11.08 8 136786 11 29815673
Tick-borne viral encephalitis 28.23 11.08 9 136785 23 29815661
Intra-abdominal haemorrhage 28.13 11.08 41 136753 2061 29813623
Cold sweat 28.13 11.08 4 136790 9078 29806606
Dyskinesia 28.09 11.08 35 136759 21799 29793885
Muscular weakness 27.95 11.08 173 136621 63472 29752212
Disturbance in attention 27.92 11.08 36 136758 22093 29793591
Electrocardiogram QT prolonged 27.88 11.08 78 136716 35757 29779927
New onset diabetes after transplantation 27.87 11.08 8 136786 12 29815672
Adverse drug reaction 27.83 11.08 39 136755 23106 29792578
Protothecosis 27.83 11.08 10 136784 41 29815643
Polyhydramnios 27.81 11.08 16 136778 227 29815457
Chronic papillomatous dermatitis 27.79 11.08 11 136783 62 29815622
Meningoencephalitis amoebic 27.53 11.08 13 136781 119 29815565
Arthritis 27.51 11.08 43 136751 24358 29791326
Sinusitis aspergillus 27.51 11.08 11 136783 64 29815620
Metastasis 27.50 11.08 52 136742 3246 29812438
Renal haematoma 27.47 11.08 21 136773 490 29815194
Gastric haemorrhage 27.46 11.08 5 136789 9462 29806222
Obstructive nephropathy 27.44 11.08 9 136785 26 29815658
Postoperative wound infection 27.44 11.08 62 136732 4393 29811291
Coccidioidomycosis 27.43 11.08 23 136771 615 29815069
Gastroenteritis eosinophilic 27.41 11.08 15 136779 192 29815492
Swollen tongue 27.32 11.08 13 136781 13179 29802505
Anaphylactic shock 27.18 11.08 15 136779 13978 29801706
Aspartate aminotransferase increased 27.03 11.08 174 136620 63248 29752436
Drug level abnormal 26.95 11.08 11 136783 68 29815616
Chronic myelomonocytic leukaemia 26.88 11.08 23 136771 633 29815051
Head injury 26.73 11.08 23 136771 16997 29798687
Meningomyelitis herpes 26.71 11.08 9 136785 29 29815655
Incision site pain 26.69 11.08 39 136755 1965 29813719
Endocarditis 26.59 11.08 74 136720 5969 29809715
Propionibacterium infection 26.58 11.08 16 136778 248 29815436
Cell death 26.57 11.08 42 136752 2269 29813415
Immune-mediated adverse reaction 26.56 11.08 20 136774 456 29815228
Blood count abnormal 26.50 11.08 10 136784 11642 29804042
Skin discolouration 26.49 11.08 20 136774 15774 29799910
Diarrhoea haemorrhagic 26.45 11.08 72 136722 5733 29809951
Pathergy reaction 26.45 11.08 7 136787 6 29815678
Haemolytic anaemia 26.39 11.08 103 136691 9907 29805777
Acarodermatitis 26.36 11.08 18 136776 350 29815334
Amnesia 26.35 11.08 44 136750 24277 29791407
Hyperglycaemia 26.28 11.08 261 136533 34939 29780745
Restlessness 26.27 11.08 39 136755 22560 29793124
Burning sensation 26.20 11.08 22 136772 16452 29799232
Dyspnoea exertional 26.19 11.08 79 136715 35351 29780333
Myelitis 26.16 11.08 23 136771 657 29815027
Renal vein thrombosis 26.11 11.08 13 136781 135 29815549
Epstein-Barr virus associated lymphoma 26.11 11.08 21 136773 529 29815155
Cryoglobulinaemia 26.03 11.08 17 136777 306 29815378
Arrhythmia 25.95 11.08 72 136722 33097 29782587
Rhinorrhoea 25.94 11.08 34 136760 20720 29794964
Lip squamous cell carcinoma 25.93 11.08 11 136783 76 29815608
Pneumonia influenzal 25.89 11.08 31 136763 1284 29814400
Pneumonia viral 25.87 11.08 45 136749 2632 29813052
Toxic skin eruption 25.82 11.08 9 136785 11006 29804678
Hepatic failure 25.70 11.08 253 136541 33790 29781894
Angina unstable 25.70 11.08 12 136782 12298 29803386
Pulmonary mass 25.64 11.08 108 136686 10754 29804930
Bronchitis 25.64 11.08 92 136702 39033 29776651
Glomerulonephropathy 25.58 11.08 12 136782 108 29815576
Urosepsis 25.56 11.08 107 136687 10625 29805059
Mouth ulceration 25.45 11.08 106 136688 10503 29805181
Cough 25.42 11.08 412 136382 125230 29690454
Anhedonia 25.20 11.08 4 136790 8365 29807319
Pain in jaw 25.14 11.08 12 136782 12144 29803540
Kidney rupture 25.11 11.08 15 136779 229 29815455
Fungal sepsis 25 11.08 23 136771 698 29814986
Adverse event 25.00 11.08 20 136774 15321 29800363
Cryptitis 24.94 11.08 8 136786 21 29815663
Stevens-Johnson syndrome 24.91 11.08 26 136768 17530 29798154
Zoonotic bacterial infection 24.89 11.08 10 136784 59 29815625
Anaplastic large cell lymphoma T- and null-cell types 24.85 11.08 12 136782 116 29815568
Normocytic anaemia 24.79 11.08 32 136762 1432 29814252
Staphylococcal scalded skin syndrome 24.74 11.08 16 136778 283 29815401
Eschar 24.72 11.08 21 136773 572 29815112
Palmar-plantar erythrodysaesthesia syndrome 24.72 11.08 19 136775 14851 29800833
Retinitis 24.69 11.08 16 136778 284 29815400
Graft infection 24.69 11.08 18 136776 390 29815294
Coma 24.63 11.08 98 136696 40351 29775333
Cognitive disorder 24.62 11.08 44 136750 23646 29792038
Bone marrow transplant 24.49 11.08 26 136768 942 29814742
Ejection fraction decreased 24.46 11.08 20 136774 15155 29800529
Paranoia 24.45 11.08 8 136786 10180 29805504
Sphincter of Oddi dysfunction 24.41 11.08 12 136782 121 29815563
Low birth weight baby 24.41 11.08 72 136722 6004 29809680
Cutaneous tuberculosis 24.35 11.08 11 136783 90 29815594
Respiratory depression 24.34 11.08 11 136783 11492 29804192
Microtia 24.23 11.08 15 136779 245 29815439
Bile duct necrosis 24.19 11.08 7 136787 11 29815673
Neoplasm progression 24.13 11.08 28 136766 17995 29797689
Ureteric anastomosis complication 24.12 11.08 9 136785 42 29815642
Brain herniation 24.10 11.08 53 136741 3687 29811997
Oesophageal ulcer 24.09 11.08 49 136745 3228 29812456
Inflammatory bowel disease 24.08 11.08 40 136754 2253 29813431
Haemodynamic instability 24.07 11.08 86 136708 7929 29807755
Abdominal distension 24.04 11.08 117 136677 45592 29770092
Cytomegalovirus gastrointestinal infection 23.99 11.08 12 136782 126 29815558
Dysphonia 23.97 11.08 31 136763 19001 29796683
Intentional product use issue 23.81 11.08 263 136531 36177 29779507
Evans syndrome 23.71 11.08 15 136779 255 29815429
Muscle abscess 23.71 11.08 19 136775 476 29815208
Trichophytic granuloma 23.70 11.08 10 136784 68 29815616
Hepatitis C virus test 23.70 11.08 10 136784 68 29815616
Hypersomnia 23.67 11.08 11 136783 11305 29804379
Blood glucose increased 23.65 11.08 174 136620 61356 29754328
Hepatitis C RNULL increased 23.61 11.08 17 136777 361 29815323
Sebaceous carcinoma 23.58 11.08 10 136784 69 29815615
Enterococcus test positive 23.56 11.08 24 136770 828 29814856
Pyrexia 23.56 11.08 1603 135191 292886 29522798
Odynophagia 23.55 11.08 59 136735 4468 29811216
Pneumonia 23.54 11.08 1268 135526 333038 29482646
Hypertrophic cardiomyopathy 23.50 11.08 25 136769 908 29814776
Surgical procedure repeated 23.49 11.08 17 136777 364 29815320
Withdrawal syndrome 23.43 11.08 11 136783 11239 29804445
Phospholipidosis 23.30 11.08 9 136785 47 29815637
Viral vasculitis 23.22 11.08 10 136784 72 29815612
Product quality issue 23.22 11.08 31 136763 18743 29796941
Cataract 23.19 11.08 40 136754 21795 29793889
Herpes simplex test positive 23.19 11.08 13 136781 175 29815509
IIIrd nerve paralysis 23.08 11.08 18 136776 433 29815251
Acinetobacter bacteraemia 23.08 11.08 11 136783 103 29815581
Incisional hernia 23.07 11.08 27 136767 1091 29814593
Depressed level of consciousness 23.03 11.08 93 136701 38129 29777555
Synovitis 22.92 11.08 8 136786 9775 29805909
Staphylococcal sepsis 22.90 11.08 95 136699 9396 29806288
Cow pox 22.82 11.08 8 136786 30 29815654
Histoplasmosis cutaneous 22.81 11.08 7 136787 15 29815669
Miosis 22.78 11.08 4 136790 7772 29807912
Respiratory tract infection fungal 22.70 11.08 21 136773 642 29815042
Steatohepatitis 22.66 11.08 16 136778 329 29815355
Dengue fever 22.62 11.08 13 136781 184 29815500
Erythropoiesis abnormal 22.62 11.08 13 136781 184 29815500
Pneumonia bacterial 22.59 11.08 94 136700 9309 29806375
Rash pruritic 22.50 11.08 43 136751 22529 29793155
Prostatic abscess 22.49 11.08 17 136777 390 29815294
Portal fibrosis 22.49 11.08 17 136777 390 29815294
Wound infection 22.46 11.08 70 136724 6015 29809669
Drug level changed 22.46 11.08 16 136778 334 29815350
Body temperature decreased 22.44 11.08 8 136786 9647 29806037
Fungal abscess central nervous system 22.41 11.08 9 136785 53 29815631
Epstein-Barr virus infection reactivation 22.23 11.08 14 136780 236 29815448
Neuroleptic malignant syndrome 22.16 11.08 25 136769 16270 29799414
Abdominal pain upper 22.11 11.08 181 136613 62370 29753314
Tumour lysis syndrome 22.02 11.08 16 136778 12869 29802815
Cryptococcal cutaneous infection 22.01 11.08 10 136784 83 29815601
Immunosuppressant drug level 21.97 11.08 5 136789 0 29815684
Bone pain 21.95 11.08 33 136761 18993 29796691
Hypertensive emergency 21.94 11.08 23 136771 821 29814863
Urinary tract infection viral 21.93 11.08 7 136787 18 29815666
Pulmonary tuberculosis 21.89 11.08 60 136734 4797 29810887
Prostate cancer 21.88 11.08 48 136746 23909 29791775
Hepatic necrosis 21.86 11.08 52 136742 3811 29811873
Oesophageal squamous cell carcinoma 21.85 11.08 16 136778 349 29815335
Necrotising herpetic retinopathy 21.66 11.08 7 136787 19 29815665
Human ehrlichiosis 21.62 11.08 13 136781 201 29815483
Hepatitis cholestatic 21.57 11.08 82 136712 7790 29807894
Lip swelling 21.55 11.08 16 136778 12728 29802956
Eosinophilic oesophagitis 21.51 11.08 13 136781 203 29815481
Cyanosis 21.48 11.08 14 136780 11921 29803763
Adult T-cell lymphoma/leukaemia 21.44 11.08 14 136780 252 29815432
Gait inability 21.43 11.08 33 136761 18808 29796876
Deep vein thrombosis 21.42 11.08 175 136619 60326 29755358
Renal adenoma 21.40 11.08 7 136787 20 29815664
Depressed mood 21.18 11.08 28 136766 17001 29798683
Complications of bone marrow transplant 21.07 11.08 13 136781 211 29815473
Blister 20.97 11.08 39 136755 20644 29795040
Encephalitis protozoal 20.91 11.08 7 136787 22 29815662
Rabies 20.90 11.08 6 136788 9 29815675
Haemoglobin decreased 20.86 11.08 381 136413 113717 29701967
Status epilepticus 20.86 11.08 103 136691 10969 29804715
Spinal fracture 20.83 11.08 3 136791 6745 29808939
Immune thrombocytopenia 20.74 11.08 79 136715 7512 29808172
Parainfluenzae virus infection 20.67 11.08 35 136759 2003 29813681
Lymphadenopathy mediastinal 20.59 11.08 35 136759 2009 29813675
Neutrophil morphology abnormal 20.53 11.08 9 136785 68 29815616
Metastatic squamous cell carcinoma 20.48 11.08 16 136778 386 29815298
Drug intolerance 20.46 11.08 122 136672 45169 29770515
Chromaturia 20.28 11.08 20 136774 13845 29801839
Contraindicated product prescribed 20.22 11.08 15 136779 334 29815350
Biliary ischaemia 20.16 11.08 6 136788 11 29815673
Bronchial anastomosis complication 20.16 11.08 6 136788 11 29815673
Peripheral coldness 20.15 11.08 3 136791 6580 29809104
Abnormal dreams 20.14 11.08 6 136788 8109 29807575
Serratia infection 20.06 11.08 20 136774 672 29815012
Tongue necrosis 20.02 11.08 7 136787 26 29815658
Hypoacusis 19.99 11.08 21 136773 14118 29801566
Hepatitis B reactivation 19.95 11.08 42 136752 2835 29812849
Urinary incontinence 19.92 11.08 29 136765 16911 29798773
Feeling cold 19.87 11.08 9 136785 9390 29806294
Hepatitis B 19.84 11.08 67 136727 6005 29809679
Fluoride increased 19.80 11.08 8 136786 48 29815636
Gastrointestinal toxicity 19.73 11.08 34 136760 1974 29813710
Nervousness 19.67 11.08 15 136779 11773 29803911
Arteriovenous fistula aneurysm 19.63 11.08 5 136789 3 29815681
Bile output increased 19.63 11.08 5 136789 3 29815681
B-cell lymphoma 19.62 11.08 55 136739 4455 29811229
Mycobacterium fortuitum infection 19.55 11.08 12 136782 193 29815491
Basal cell carcinoma 19.49 11.08 133 136661 15935 29799749
Face oedema 19.46 11.08 14 136780 11320 29804364
Dementia 19.38 11.08 17 136777 12444 29803240
Cerebral cyst 19.33 11.08 12 136782 197 29815487
Post procedural complication 19.26 11.08 105 136689 11621 29804063
Red blood cell count decreased 19.23 11.08 59 136735 26262 29789422
Second primary malignancy 19.22 11.08 3 136791 6353 29809331
Sinusitis bacterial 19.22 11.08 14 136780 303 29815381
Complications of transplanted pancreas 19.20 11.08 6 136788 14 29815670
Transplant 19.19 11.08 19 136775 633 29815051
Glomerulonephritis rapidly progressive 19.14 11.08 16 136778 426 29815258
Blood creatine increased 19.14 11.08 54 136740 4391 29811293
Pneumoperitoneum 19.12 11.08 30 136764 1610 29814074
Pyuria 19.07 11.08 19 136775 638 29815046
Renal arteriosclerosis 19.06 11.08 11 136783 157 29815527
Pericardial fibrosis 19.05 11.08 7 136787 31 29815653
Hemianopia heteronymous 19.05 11.08 7 136787 31 29815653
Pharyngeal polyp 19.05 11.08 5 136789 4 29815680
Heart transplant 19.01 11.08 17 136777 497 29815187
Enterovirus infection 18.93 11.08 18 136776 570 29815114
Ureteritis 18.91 11.08 6 136788 15 29815669
Radiculitis brachial 18.91 11.08 6 136788 15 29815669
Petechiae 18.91 11.08 9 136785 9122 29806562
Reticulocytopenia 18.89 11.08 8 136786 55 29815629
Disseminated trichosporonosis 18.89 11.08 8 136786 55 29815629
Pancreatitis necrotising 18.88 11.08 37 136757 2372 29813312
Coronary artery occlusion 18.87 11.08 14 136780 11143 29804541
Urethral stenosis 18.80 11.08 19 136775 649 29815035
Hip fracture 18.76 11.08 14 136780 11110 29804574
Multiple sclerosis 18.73 11.08 5 136789 7262 29808422
Eye infection fungal 18.71 11.08 14 136780 316 29815368
Stomatitis 18.70 11.08 97 136697 37182 29778502
Argentine haemorrhagic fever 18.64 11.08 6 136788 16 29815668
Passenger lymphocyte syndrome 18.64 11.08 6 136788 16 29815668
Limb discomfort 18.62 11.08 9 136785 9041 29806643
Lymphangitis 18.61 11.08 17 136777 511 29815173
Ocular hyperaemia 18.59 11.08 9 136785 9034 29806650
Pericarditis constrictive 18.55 11.08 13 136781 264 29815420
Chimerism 18.55 11.08 9 136785 88 29815596
Adenovirus test positive 18.54 11.08 7 136787 34 29815650
Renal and pancreas transplant rejection 18.54 11.08 7 136787 34 29815650
Pseudohypoaldosteronism 18.52 11.08 5 136789 5 29815679
Nephritis 18.51 11.08 34 136760 2076 29813608
Isosporiasis 18.46 11.08 9 136785 89 29815595
Abscess 18.45 11.08 93 136701 9985 29805699
Throat tightness 18.44 11.08 5 136789 7187 29808497
Cardiac valve vegetation 18.44 11.08 16 136778 449 29815235
Pulmonary alveolar haemorrhage 18.40 11.08 69 136725 6512 29809172
Device malfunction 18.38 11.08 7 136787 8104 29807580
Product prescribing error 18.38 11.08 30 136764 16703 29798981
Cyclosporidium infection 18.38 11.08 6 136788 17 29815667
Underdose 18.36 11.08 17 136777 12124 29803560
Febrile neutropenia 18.35 11.08 360 136434 106333 29709351
Eye swelling 18.31 11.08 9 136785 8955 29806729
Influenza like illness 18.28 11.08 58 136736 25547 29790137
Hyperplasia 18.26 11.08 17 136777 524 29815160
Optic atrophy 18.15 11.08 20 136774 756 29814928
Hypoaldosteronism 18.08 11.08 11 136783 174 29815510
Hepatitis infectious mononucleosis 18.06 11.08 7 136787 37 29815647
Salivary hypersecretion 18.05 11.08 6 136788 7560 29808124
Urinary retention 18.05 11.08 83 136711 32834 29782850
Tonsillar hypertrophy 18.02 11.08 17 136777 533 29815151
Pneumonia aspiration 18.01 11.08 100 136694 37680 29778004
Burkitt's lymphoma 17.97 11.08 11 136783 176 29815508
Urine output decreased 17.97 11.08 90 136704 9639 29806045
Tubulointerstitial nephritis and uveitis syndrome 17.90 11.08 7 136787 38 29815646
Cutaneous nocardiosis 17.87 11.08 9 136785 96 29815588
Hepatic haematoma 17.77 11.08 16 136778 472 29815212
Escherichia test positive 17.74 11.08 23 136771 1034 29814650
Klebsiella bacteraemia 17.74 11.08 23 136771 1034 29814650
Encephalitis fungal 17.70 11.08 11 136783 181 29815503
Dyslipidaemia 17.67 11.08 62 136732 5665 29810019
Pneumopericardium 17.65 11.08 8 136786 66 29815618
Pseudomonal sepsis 17.64 11.08 41 136753 2959 29812725
Gastritis fungal 17.63 11.08 9 136785 99 29815585
Segmented hyalinising vasculitis 17.61 11.08 7 136787 40 29815644
Cystitis glandularis 17.57 11.08 4 136790 0 29815684
Interferon gamma decreased 17.57 11.08 4 136790 0 29815684
Pharyngeal oedema 17.56 11.08 4 136790 6467 29809217
Atypical haemolytic uraemic syndrome 17.55 11.08 9 136785 100 29815584
Reversible cerebral vasoconstriction syndrome 17.50 11.08 12 136782 235 29815449
Congenital oesophageal anomaly 17.47 11.08 9 136785 101 29815583
Bronchospasm 17.45 11.08 13 136781 10325 29805359
Lower respiratory tract infection 17.38 11.08 63 136731 26651 29789033
Activated partial thromboplastin time prolonged 17.34 11.08 7 136787 7821 29807863
T-cell lymphoma stage IV 17.31 11.08 10 136784 143 29815541
Granulomatous liver disease 17.27 11.08 16 136778 490 29815194
Vascular pseudoaneurysm 17.26 11.08 32 136762 1968 29813716
Metastases to abdominal cavity 17.25 11.08 9 136785 104 29815580
Sporotrichosis 17.19 11.08 7 136787 43 29815641
Haemolysis 17.15 11.08 72 136722 7159 29808525
Ventricular tachycardia 17.07 11.08 54 136740 23808 29791876
Renal vessel disorder 17.07 11.08 12 136782 245 29815439
Hiccups 17.07 11.08 11 136783 9423 29806261
Pulmonary thrombosis 17.05 11.08 4 136790 6339 29809345
Cranial nerve paralysis 17.01 11.08 6 136788 23 29815661
Encephalitis autoimmune 16.99 11.08 15 136779 431 29815253
Sinus bradycardia 16.96 11.08 17 136777 11678 29804006
Sleep apnoea syndrome 16.90 11.08 32 136762 16825 29798859
Musculoskeletal discomfort 16.88 11.08 4 136790 6296 29809388
Red blood cell schistocytes present 16.87 11.08 13 136781 307 29815377
Varicella virus test positive 16.87 11.08 8 136786 74 29815610
Feeling hot 16.84 11.08 28 136766 15476 29800208
Sinus tachycardia 16.84 11.08 28 136766 15476 29800208
Artery dissection 16.81 11.08 9 136785 110 29815574
Asthenospermia 16.79 11.08 7 136787 46 29815638
Necrosis 16.79 11.08 57 136737 5122 29810562
Pneumonia adenoviral 16.72 11.08 10 136784 153 29815531
Red blood cells urine positive 16.70 11.08 28 136766 1589 29814095
Bone disorder 16.70 11.08 5 136789 6736 29808948
Product dispensing error 16.68 11.08 62 136732 5827 29809857
Chromoblastomycosis 16.67 11.08 7 136787 47 29815637
Cardiac arrest 16.67 11.08 311 136483 92539 29723145
Abscess fungal 16.67 11.08 10 136784 154 29815530
Dysarthria 16.64 11.08 77 136717 30413 29785271
Transitional cell carcinoma metastatic 16.62 11.08 6 136788 25 29815659
Mood swings 16.60 11.08 7 136787 7619 29808065
Sinusitis 16.60 11.08 87 136707 33258 29782426
Central nervous system fungal infection 16.58 11.08 12 136782 257 29815427
T-cell lymphoma 16.51 11.08 21 136773 926 29814758
Joint injury 16.46 11.08 5 136789 6672 29809012
Infected lymphocele 16.44 11.08 6 136788 26 29815658
Skin abrasion 16.43 11.08 4 136790 6182 29809502
Infective aneurysm 16.43 11.08 14 136780 383 29815301
Quadriplegia 16.42 11.08 27 136767 1508 29814176
Paraspinal abscess 16.42 11.08 8 136786 79 29815605
Epstein-Barr virus antibody positive 16.38 11.08 13 136781 321 29815363
Mediastinitis 16.34 11.08 16 136778 526 29815158
Herpes virus infection 16.33 11.08 36 136758 2508 29813176
Necrotising fasciitis fungal 16.20 11.08 5 136789 11 29815673
Oral papilloma 16.20 11.08 5 136789 11 29815673
Pericarditis infective 16.19 11.08 7 136787 51 29815633
Myeloma cast nephropathy 16.19 11.08 7 136787 51 29815633
Hepatitis A 16.17 11.08 15 136779 460 29815224
Malabsorption 16.16 11.08 31 136763 1956 29813728
Lymphorrhoea 16.16 11.08 8 136786 82 29815602
Thrombotic thrombocytopenic purpura 16.13 11.08 43 136751 3382 29812302
Intussusception 16.11 11.08 16 136778 535 29815149
Bacteriuria 16.11 11.08 12 136782 269 29815415
Endothelial dysfunction 16.08 11.08 6 136788 28 29815656
Pyogenic granuloma 16.06 11.08 11 136783 215 29815469
Medication error 16.05 11.08 46 136748 20926 29794758
Nephrocalcinosis 16.01 11.08 15 136779 466 29815218
Nocturia 16.01 11.08 9 136785 8303 29807381
Metastases to lung 15.99 11.08 75 136719 7820 29807864
Abdominal infection 15.96 11.08 26 136768 1441 29814243
Muscle rigidity 15.95 11.08 14 136780 10247 29805437
Bronchiolitis obliterans syndrome 15.91 11.08 6 136788 29 29815655
Extranodal marginal zone B-cell lymphoma (MALT type) 15.91 11.08 10 136784 168 29815516
Sudden death 15.89 11.08 29 136765 15463 29800221
Pneumonia legionella 15.88 11.08 27 136767 1550 29814134
Meningitis fungal 15.87 11.08 9 136785 124 29815560
Tuberculosis of central nervous system 15.81 11.08 10 136784 170 29815514
Dialysis 15.79 11.08 95 136699 10901 29804783
Incorrect route of product administration 15.78 11.08 17 136777 11298 29804386
Blood pressure systolic increased 15.76 11.08 28 136766 15082 29800602
Cushingoid 15.75 11.08 35 136759 2452 29813232
Encephalomyelitis 15.75 11.08 6 136788 30 29815654
Phaeohyphomycotic brain abscess 15.75 11.08 6 136788 30 29815654
Vertigo 15.65 11.08 52 136742 22583 29793101
B-lymphocyte abnormalities 15.62 11.08 5 136789 13 29815671
Adhesiolysis 15.62 11.08 5 136789 13 29815671
Skin squamous cell carcinoma recurrent 15.62 11.08 5 136789 13 29815671
Visceral leishmaniasis 15.62 11.08 15 136779 481 29815203
Periodontitis 15.60 11.08 28 136766 1679 29814005
Herpes zoster reactivation 15.59 11.08 6 136788 31 29815653
Biliary anastomosis 15.59 11.08 6 136788 31 29815653
Epidermodysplasia verruciformis 15.59 11.08 6 136788 31 29815653
Laryngeal mass 15.59 11.08 6 136788 31 29815653
Brucellosis 15.59 11.08 6 136788 31 29815653
Limb injury 15.58 11.08 11 136783 8980 29806704
Respiratory syncytial virus infection 15.57 11.08 42 136752 3326 29812358
Nephrosclerosis 15.57 11.08 19 136775 803 29814881
Sweat gland tumour 15.55 11.08 14 136780 413 29815271
Lung abscess 15.52 11.08 35 136759 2476 29813208
Discomfort 15.52 11.08 26 136768 14330 29801354
Leiomyosarcoma 15.50 11.08 9 136785 130 29815554
Asphyxia 15.44 11.08 3 136791 5422 29810262
Penicillium infection 15.44 11.08 8 136786 91 29815593
Throat irritation 15.42 11.08 10 136784 8538 29807146
Eosinophilic colitis 15.41 11.08 10 136784 178 29815506
Red blood cell sedimentation rate increased 15.40 11.08 7 136787 7288 29808396
Pneumonia herpes viral 15.36 11.08 8 136786 92 29815592
Renal cancer stage I 15.36 11.08 5 136789 14 29815670
Oesophageal compression 15.35 11.08 4 136790 3 29815681
Disseminated varicella 15.35 11.08 4 136790 3 29815681
Cytomegalovirus myocarditis 15.35 11.08 4 136790 3 29815681
Leuconostoc infection 15.35 11.08 4 136790 3 29815681
Akathisia 15.33 11.08 4 136790 5900 29809784
Psychotic disorder 15.18 11.08 49 136745 21466 29794218
Alcohol abuse 15.16 11.08 3 136791 5350 29810334
Retinal ischaemia 15.15 11.08 13 136781 359 29815325
Lymphocytic infiltration 15.15 11.08 16 136778 576 29815108
Rash macular 15.11 11.08 15 136779 10352 29805332
Spontaneous intrahepatic portosystemic venous shunt 15.10 11.08 5 136789 15 29815669
Biliary dilatation 15.06 11.08 18 136776 744 29814940
Wound infection fungal 14.99 11.08 6 136788 35 29815649
Ureaplasma infection 14.98 11.08 10 136784 187 29815497
Endocarditis enterococcal 14.92 11.08 8 136786 98 29815586
Hyperparathyroidism 14.89 11.08 20 136774 931 29814753
Body temperature increased 14.87 11.08 28 136766 14752 29800932
Sebaceous adenoma 14.87 11.08 5 136789 16 29815668
Tooth disorder 14.86 11.08 12 136782 9149 29806535
Splenic haemorrhage 14.83 11.08 13 136781 370 29815314
Middle insomnia 14.82 11.08 4 136790 5769 29809915
Abdominal rebound tenderness 14.82 11.08 4 136790 4 29815680
Nocardia sepsis 14.82 11.08 4 136790 4 29815680
Acquired porokeratosis 14.82 11.08 4 136790 4 29815680
Foetal exposure during pregnancy 14.78 11.08 103 136691 36768 29778916
Morganella infection 14.77 11.08 13 136781 372 29815312
Lung consolidation 14.76 11.08 53 136741 4899 29810785
Sputum discoloured 14.71 11.08 6 136788 6662 29809022
Graft haemorrhage 14.64 11.08 7 136787 66 29815618
Food interaction 14.62 11.08 19 136775 856 29814828
Musculoskeletal chest pain 14.61 11.08 12 136782 9073 29806611
Enterobacter pneumonia 14.58 11.08 6 136788 38 29815646
Arm amputation 14.58 11.08 8 136786 103 29815581
Jejunal perforation 14.58 11.08 10 136784 196 29815488
Pharyngeal abscess 14.55 11.08 14 136780 450 29815234
Nephritic syndrome 14.55 11.08 7 136787 67 29815617
Gastric disorder 14.53 11.08 16 136778 10527 29805157
Lung squamous cell carcinoma stage IV 14.45 11.08 6 136788 39 29815645
Procedural pneumothorax 14.45 11.08 6 136788 39 29815645
Inhibin B 14.42 11.08 5 136789 18 29815666
Upper respiratory fungal infection 14.42 11.08 5 136789 18 29815666
Dysstasia 14.41 11.08 16 136778 10489 29805195
Colitis ulcerative 14.37 11.08 114 136680 14320 29801364
Serositis 14.33 11.08 9 136785 151 29815533
Accidental exposure to product 14.33 11.08 15 136779 10100 29805584
Anorectal varices 14.32 11.08 6 136788 40 29815644
Pulmonary oedema 14.31 11.08 130 136664 43845 29771839
Hydrops foetalis 14.31 11.08 11 136783 259 29815425
Hernial eventration 14.29 11.08 7 136787 70 29815614
Hypochromic anaemia 14.29 11.08 18 136776 786 29814898
Circulatory collapse 14.28 11.08 46 136748 20168 29795516
Immunosuppression 14.26 11.08 54 136740 5121 29810563
Influenza 14.25 11.08 128 136666 43270 29772414
Acquired macroglossia 14.21 11.08 5 136789 19 29815665
Fungating wound 14.21 11.08 5 136789 19 29815665
Mucosal hypertrophy 14.21 11.08 5 136789 19 29815665
Human herpes virus 8 test positive 14.21 11.08 5 136789 19 29815665
Peritoneal candidiasis 14.21 11.08 5 136789 19 29815665
Splenic peliosis 14.21 11.08 5 136789 19 29815665
Vascular pseudoaneurysm ruptured 14.20 11.08 7 136787 71 29815613
Sinusitis fungal 14.20 11.08 13 136781 392 29815292
Post streptococcal glomerulonephritis 14.20 11.08 6 136788 41 29815643
Crying 14.19 11.08 4 136790 5605 29810079
Ageusia 14.18 11.08 12 136782 8941 29806743
Limbic encephalitis 14.16 11.08 11 136783 263 29815421
Ventricular extrasystoles 14.13 11.08 19 136775 11455 29804229
C-reactive protein abnormal 14.13 11.08 4 136790 5589 29810095
Pallor 14.12 11.08 49 136745 21000 29794684
Legionella infection 14.12 11.08 13 136781 395 29815289
Pulmonary cavitation 14.10 11.08 17 136777 709 29814975
Arteriovenous fistula thrombosis 14.09 11.08 12 136782 328 29815356
Photosensitivity reaction 14.08 11.08 84 136710 9610 29806074
Hepatosplenomegaly 14.06 11.08 43 136751 3658 29812026
Myelodysplastic syndrome unclassifiable 14.01 11.08 5 136789 20 29815664
Respiratory distress 14.01 11.08 220 136574 32752 29782932
Rash maculo-papular 13.99 11.08 64 136730 25354 29790330
Molluscum contagiosum 13.95 11.08 11 136783 269 29815415
Uraemic encephalopathy 13.92 11.08 11 136783 270 29815414
Bone marrow failure 13.92 11.08 202 136592 29583 29786101
B-lymphocyte count decreased 13.91 11.08 14 136780 476 29815208
Sexual dysfunction 13.90 11.08 5 136789 5996 29809688
Alanine aminotransferase increased 13.89 11.08 247 136547 74029 29741655
Osteomyelitis chronic 13.88 11.08 11 136783 271 29815413
Troponin increased 13.87 11.08 12 136782 8845 29806839
Microangiopathic haemolytic anaemia 13.85 11.08 18 136776 811 29814873
Hepatitis viral 13.84 11.08 14 136780 479 29815205
Tuberculosis gastrointestinal 13.82 11.08 10 136784 214 29815470
Renal cell carcinoma stage I 13.82 11.08 5 136789 21 29815663
Disseminated tuberculosis 13.79 11.08 30 136764 2072 29813612
Pneumococcal infection 13.76 11.08 12 136782 339 29815345
Lymphadenopathy 13.73 11.08 171 136623 24205 29791479
Metabolic acidosis 13.73 11.08 244 136550 37217 29778467
Eating disorder 13.72 11.08 7 136787 6820 29808864
Unresponsive to stimuli 13.67 11.08 68 136726 26351 29789333
Myopathy 13.66 11.08 89 136705 10497 29805187
Restrictive allograft syndrome 13.64 11.08 5 136789 22 29815662
Resting tremor 13.62 11.08 15 136779 567 29815117
Septic embolus 13.56 11.08 21 136773 1114 29814570
Endocarditis viral 13.56 11.08 4 136790 7 29815677
St. Louis encephalitis 13.56 11.08 4 136790 7 29815677
Splenic infection fungal 13.56 11.08 7 136787 79 29815605
Hepatitis B surface antigen positive 13.52 11.08 8 136786 120 29815564
Hepatitis C RNULL positive 13.51 11.08 10 136784 222 29815462
Splenic necrosis 13.50 11.08 6 136788 47 29815637
Disseminated varicella zoster vaccine virus infection 13.50 11.08 6 136788 47 29815637
Leukaemia recurrent 13.50 11.08 25 136769 1536 29814148
Blood sodium decreased 13.49 11.08 33 136761 15823 29799861
Milk allergy 13.48 11.08 7 136787 80 29815604
Oral pain 13.46 11.08 14 136780 9455 29806229
Rotator cuff syndrome 13.44 11.08 4 136790 5409 29810275
Pseudopolyp 13.41 11.08 9 136785 170 29815514
Dyschromatopsia 13.38 11.08 11 136783 286 29815398
Haemoperitoneum 13.35 11.08 24 136770 1441 29814243
Q fever 13.34 11.08 8 136786 123 29815561
Papilloma 13.34 11.08 8 136786 123 29815561
Tonsil cancer 13.34 11.08 17 136777 751 29814933
Congenital cystic lung 13.32 11.08 10 136784 227 29815457
Panic attack 13.31 11.08 12 136782 8669 29807015
IVth nerve paralysis 13.29 11.08 6 136788 49 29815635
Cardiac index increased 13.29 11.08 5 136789 24 29815660
Hypertrophic osteoarthropathy 13.26 11.08 7 136787 83 29815601
Citrobacter infection 13.24 11.08 14 136780 505 29815179
Viral skin infection 13.22 11.08 4 136790 8 29815676
Toothache 13.20 11.08 5 136789 5806 29809878
Enterocolitis viral 13.19 11.08 6 136788 50 29815634
Small intestine transplant 13.18 11.08 3 136791 0 29815684
Congenital jaw malformation 13.18 11.08 3 136791 0 29815684
Herpes zoster infection neurological 13.18 11.08 3 136791 0 29815684
Incision site discharge 13.18 11.08 3 136791 0 29815684
Leukoencephalomyelitis 13.18 11.08 3 136791 0 29815684
Aeromonas test positive 13.18 11.08 3 136791 0 29815684
Pulmonary sensitisation 13.18 11.08 3 136791 0 29815684
Optic pathway injury 13.18 11.08 3 136791 0 29815684
Schistocytosis 13.18 11.08 3 136791 0 29815684
Systemic bacterial infection 13.18 11.08 3 136791 0 29815684
Retroperitoneal effusion 13.18 11.08 3 136791 0 29815684
Exserohilum infection 13.18 11.08 3 136791 0 29815684
Conjunctival neoplasm 13.18 11.08 3 136791 0 29815684
Bile duct cancer recurrent 13.18 11.08 3 136791 0 29815684
Granulicatella infection 13.18 11.08 3 136791 0 29815684
Fluid retention 13.13 11.08 64 136730 24934 29790750
Blood pressure diastolic decreased 13.12 11.08 6 136788 6225 29809459
Sinus disorder 13.10 11.08 6 136788 6219 29809465
Lacrimation increased 12.94 11.08 8 136786 7008 29808676
Aphthous ulcer 12.92 11.08 45 136749 4096 29811588
Wound 12.92 11.08 23 136771 12379 29803305
Pneumonitis 12.91 11.08 73 136721 27381 29788303
Hyperoxaluria 12.91 11.08 8 136786 131 29815553
Blood glucose decreased 12.89 11.08 25 136769 13028 29802656
Pneumonia staphylococcal 12.85 11.08 36 136758 2915 29812769
Epstein Barr virus positive mucocutaneous ulcer 12.81 11.08 10 136784 241 29815443
Gastroenteritis 12.79 11.08 104 136690 13162 29802522
Seizure 12.79 11.08 347 136447 98128 29717556
Acid fast bacilli infection 12.76 11.08 7 136787 90 29815594
Anastomotic haemorrhage 12.75 11.08 8 136786 134 29815550
Inflammatory myofibroblastic tumour 12.75 11.08 8 136786 134 29815550
Large intestine infection 12.72 11.08 22 136772 1281 29814403
Infertility 12.67 11.08 9 136785 187 29815497
Asymptomatic viral hepatitis 12.66 11.08 5 136789 28 29815656
Gonococcal infection 12.66 11.08 5 136789 28 29815656
Myocardial strain 12.63 11.08 7 136787 92 29815592
Gingival cancer 12.61 11.08 4 136790 10 29815674
Tropical spastic paresis 12.61 11.08 4 136790 10 29815674
Transmission of an infectious agent via transplant 12.61 11.08 4 136790 10 29815674
Parathyroid disorder 12.60 11.08 6 136788 56 29815628
Glomerular vascular disorder 12.60 11.08 6 136788 56 29815628
Impaired work ability 12.57 11.08 5 136789 5638 29810046
Knee arthroplasty 12.53 11.08 5 136789 5625 29810059
Bronchomalacia 12.52 11.08 5 136789 29 29815655
Lentigo maligna 12.50 11.08 10 136784 250 29815434
Cardiomegaly 12.50 11.08 30 136764 14479 29801205
Potentiating drug interaction 12.49 11.08 48 136746 4583 29811101
Failure to thrive 12.48 11.08 71 136723 7983 29807701
Papule 12.46 11.08 37 136757 3096 29812588
Restless legs syndrome 12.45 11.08 8 136786 6864 29808820
Central nervous system vasculitis 12.44 11.08 12 136782 387 29815297
Muscle contractions involuntary 12.43 11.08 26 136768 1747 29813937
Cytomegalovirus gastrointestinal ulcer 12.38 11.08 5 136789 30 29815654
Roseolovirus test positive 12.37 11.08 7 136787 96 29815588
Factor V Leiden mutation 12.34 11.08 4 136790 11 29815673
Parvimonas micra infection 12.34 11.08 4 136790 11 29815673
Oesophageal tuberculosis 12.34 11.08 4 136790 11 29815673
Hepatic vein thrombosis 12.34 11.08 6 136788 59 29815625
Arteriosclerosis coronary artery 12.31 11.08 20 136774 11156 29804528
Rhinovirus infection 12.30 11.08 35 136759 2860 29812824
Wound infection pseudomonas 12.30 11.08 10 136784 256 29815428
Chronic lymphocytic leukaemia 12.28 11.08 3 136791 4625 29811059
Pancreatitis 12.26 11.08 107 136687 36383 29779301
Renal disorder 12.25 11.08 163 136631 23421 29792263
Type 3 diabetes mellitus 12.24 11.08 5 136789 31 29815653
Ischaemic stroke 12.24 11.08 36 136758 16239 29799445
Pleuropericarditis 12.23 11.08 9 136785 198 29815486
Obstructive airways disorder 12.21 11.08 14 136780 9045 29806639
Product administration error 12.17 11.08 30 136764 14347 29801337
Localised infection 12.15 11.08 28 136766 13709 29801975
Palatal ulcer 12.11 11.08 5 136789 32 29815652
T-lymphocyte count abnormal 12.08 11.08 4 136790 12 29815672
Leukoencephalopathy 12.07 11.08 43 136751 3959 29811725
Acanthamoeba keratitis 12.06 11.08 7 136787 101 29815583
Bowen's disease 12.06 11.08 8 136786 148 29815536
Haemorrhagic pneumonia 12.06 11.08 8 136786 148 29815536
Joint stiffness 12.04 11.08 15 136779 9346 29806338
Giardiasis 12.00 11.08 10 136784 265 29815419
Lupus nephritis 12.00 11.08 10 136784 265 29815419
Neutrophilic dermatosis 12.00 11.08 9 136785 204 29815480
Removal of renal transplant 11.98 11.08 5 136789 33 29815651
Oedema 11.95 11.08 132 136662 42861 29772823
Bronchopneumopathy 11.95 11.08 12 136782 407 29815277
Gastrointestinal fungal infection 11.94 11.08 7 136787 103 29815581
Genitourinary tract infection 11.94 11.08 7 136787 103 29815581
Ophthalmic herpes zoster 11.94 11.08 15 136779 653 29815031
Extrapyramidal disorder 11.90 11.08 19 136775 10674 29805010
Pancreatitis acute 11.90 11.08 174 136620 25521 29790163
Skin mass 11.89 11.08 39 136755 3443 29812241
Apoptosis 11.88 11.08 9 136785 207 29815477
Pulmonary arterial hypertension 11.87 11.08 15 136779 9286 29806398
Hyperamylasaemia 11.86 11.08 14 136780 571 29815113
Splenic neoplasm malignancy unspecified 11.85 11.08 4 136790 13 29815671
Superinfection viral 11.85 11.08 4 136790 13 29815671
Otitis media 11.83 11.08 32 136762 2539 29813145
Myocardial ischaemia 11.83 11.08 40 136754 17277 29798407
Cardiac pseudoaneurysm 11.73 11.08 5 136789 35 29815649
Fungal test positive 11.70 11.08 13 136781 496 29815188
Multiple congenital abnormalities 11.66 11.08 13 136781 498 29815186
Decubitus ulcer 11.66 11.08 11 136783 7777 29807907
Granulocytopenia 11.62 11.08 7 136787 6219 29809465
Urinary tract inflammation 11.62 11.08 4 136790 14 29815670
Endotoxic shock 11.62 11.08 4 136790 14 29815670
Keloid scar 11.61 11.08 5 136789 36 29815648
Pollakiuria 11.58 11.08 39 136755 16867 29798817
Prescribed underdose 11.57 11.08 11 136783 7748 29807936
Vascular graft complication 11.54 11.08 7 136787 110 29815574
Movement disorder 11.54 11.08 17 136777 9866 29805818
Pseudomembranous colitis 11.53 11.08 34 136760 2834 29812850
Alpha haemolytic streptococcal infection 11.52 11.08 16 136778 769 29814915
HLA marker study positive 11.49 11.08 7 136787 111 29815573
Internal haemorrhage 11.48 11.08 3 136791 4419 29811265
Arteritis 11.45 11.08 10 136784 283 29815401
Haemorrhage 11.45 11.08 145 136649 45934 29769750
Acute disseminated encephalomyelitis 11.45 11.08 6 136788 70 29815614
Thyroid stimulating hormone deficiency 11.41 11.08 4 136790 15 29815669
Biopsy liver abnormal 11.40 11.08 8 136786 163 29815521
Small cell carcinoma 11.38 11.08 7 136787 113 29815571
Metastases to lymph nodes 11.37 11.08 42 136752 3935 29811749
Splenic rupture 11.33 11.08 23 136771 1513 29814171
Brain oedema 11.31 11.08 96 136698 12302 29803382
Angioimmunoblastic T-cell lymphoma 11.30 11.08 11 136783 359 29815325
Continuous haemodiafiltration 11.29 11.08 19 136775 1082 29814602
Escherichia bacteraemia 11.29 11.08 34 136760 2868 29812816
Escherichia sepsis 11.27 11.08 42 136752 3952 29811732
Pleural effusion 11.24 11.08 429 136365 73637 29742047
Anti-GAD antibody positive 11.21 11.08 4 136790 16 29815668
Parkinsonism 11.20 11.08 10 136784 7259 29808425
Tooth extraction 11.16 11.08 4 136790 4807 29810877
Portal hypertension 11.16 11.08 41 136753 3832 29811852
Intestinal ulcer 11.15 11.08 16 136778 793 29814891
Infectious pleural effusion 11.13 11.08 27 136767 2003 29813681
Erythema multiforme 11.13 11.08 12 136782 7973 29807711
Schizophrenia 11.13 11.08 15 136779 9033 29806651
Wound evisceration 11.12 11.08 7 136787 118 29815566
Aortic injury 11.12 11.08 3 136791 3 29815681
Renal arteritis 11.12 11.08 3 136791 3 29815681
Myocarditis mycotic 11.12 11.08 3 136791 3 29815681
Solid organ transplant rejection 11.12 11.08 3 136791 3 29815681
Burkholderia cepacia complex sepsis 11.12 11.08 3 136791 3 29815681
Intracranial infection 11.12 11.08 3 136791 3 29815681
Balamuthia infection 11.12 11.08 3 136791 3 29815681
Sialocele 11.12 11.08 3 136791 3 29815681
Hepatic artery aneurysm 11.12 11.08 3 136791 3 29815681
Epstein-Barr virus test negative 11.12 11.08 3 136791 3 29815681
Meningitis candida 11.09 11.08 6 136788 75 29815609
Speech disorder 11.08 11.08 66 136728 24446 29791238

Pharmacologic Action:

SourceCodeDescription
ATC D11AH01 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Agents for dermatitis, excluding corticosteroids
ATC L04AD02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Calcineurin inhibitors
FDA EPC N0000175457 Calcineurin Inhibitor Immunosuppressant
FDA MoA N0000175458 Calcineurin Inhibitors
MeSH PA D065095 Calcineurin Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
CHEBI has role CHEBI:35705 immunosuppressant

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Atopic dermatitis indication 24079001 DOID:3310
Transplanted organ rejection indication 213148006
Liver transplant rejection indication 235911006
Renal transplant rejection indication 236570004
Prevention of Cardiac Transplant Rejection indication
Prevention of Transplant Rejection indication
Prevention of Liver Transplant Rejection indication
Intractable Eczema indication
Prevention of Kidney Transplant Rejection indication
Prevention of Lung Transplant Rejection off-label use
Delirium contraindication 2776000
Herpes zoster contraindication 4740000 DOID:8536
Hyperkalemia contraindication 14140009
Progressive multifocal leukoencephalopathy contraindication 22255007 DOID:643
Constitutional aplastic anemia contraindication 28975000 DOID:1342
Lymphadenopathy contraindication 30746006
Torsades de pointes contraindication 31722008
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Mental handicap contraindication 47437004
Chronic heart failure contraindication 48447003
Left ventricular hypertrophy contraindication 55827005
Hepatic failure contraindication 59927004
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Herpes simplex contraindication 88594005 DOID:8566
Kidney disease contraindication 90708001 DOID:557
Prolonged QT interval contraindication 111975006
Malignant lymphoma contraindication 118600007 DOID:0060058
Seizure disorder contraindication 128613002
Eczema herpeticum contraindication 186535001 DOID:9123
Toxic nephropathy contraindication 236514003
Post-transplant lymphoproliferative disorder contraindication 254290004
Infectious mononucleosis contraindication 271558008 DOID:8568
Netherton's syndrome contraindication 312514006
Coma contraindication 371632003
Primary malignant neoplasm contraindication 372087000
Neuropathy contraindication 386033004 DOID:870
Breastfeeding (mother) contraindication 413712001
Congenital long QT syndrome contraindication 442917000
Posterior reversible encephalopathy syndrome contraindication 450886002
Tacrolimus Toxicity contraindication
Tremors contraindication
BK Polyomavirus Reactivation Nephropathy contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.4 acidic
pKa2 13.12 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL July 10, 2022 PROPHYLAXIS OF ORGAN REJECTION IN KIDNEY TRANSPLANT PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS IN COMBINULLTION WITH OTHER IMMUNOSUPPRESSANTS
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL July 10, 2022 PROPHYLAXIS OF ORGAN REJECTION IN KIDNEY TRANSPLANT PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS IN COMBINULLTION WITH OTHER IMMUNOSUPPRESSANTS
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL July 10, 2022 PROPHYLAXIS OF ORGAN REJECTION IN KIDNEY TRANSPLANT PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS IN COMBINULLTION WITH OTHER IMMUNOSUPPRESSANTS
EQ 0.5MG BASE PROGRAF ASTELLAS N050708 Aug. 24, 1998 RX CAPSULE ORAL May 24, 2025 PROPHYLAXIS OF ORGAN REJECTION IN PEDIATRIC PATIENTS RECEIVING ALLOGENEIC KIDNEY OR HEART TRANSPLANTS, IN COMBINULLTION WITH OTHER IMMUNOSUPPRESSANTS
EQ 1MG BASE PROGRAF ASTELLAS N050708 April 8, 1994 RX CAPSULE ORAL May 24, 2025 PROPHYLAXIS OF ORGAN REJECTION IN PEDIATRIC PATIENTS RECEIVING ALLOGENEIC KIDNEY OR HEART TRANSPLANTS, IN COMBINULLTION WITH OTHER IMMUNOSUPPRESSANTS
EQ 5MG BASE PROGRAF ASTELLAS N050708 April 8, 1994 RX CAPSULE ORAL May 24, 2025 PROPHYLAXIS OF ORGAN REJECTION IN PEDIATRIC PATIENTS RECEIVING ALLOGENEIC KIDNEY OR HEART TRANSPLANTS, IN COMBINULLTION WITH OTHER IMMUNOSUPPRESSANTS
EQ 5MG BASE/ML PROGRAF ASTELLAS N050709 April 8, 1994 RX INJECTABLE INJECTION May 24, 2025 PROPHYLAXIS OF ORGAN REJECTION IN PEDIATRIC PATIENTS RECEIVING ALLOGENEIC KIDNEY OR HEART TRANSPLANTS, IN COMBINULLTION WITH OTHER IMMUNOSUPPRESSANTS
EQ 0.5MG BASE ASTAGRAF XL ASTELLAS N204096 July 19, 2013 RX CAPSULE, EXTENDED RELEASE ORAL May 24, 2025 FDA HAS NOT RECOGNIZED ORPHAN-DRUG EXCLUSIVITY (ODE) FOR THIS DRUG, BUT IT CONTAINS THE SAME ACTIVE MOIETY OR MOIETIES AS ANOTHER DRUG(S) THAT WAS ELIGIBLE FOR ODE, AND ALSO SHARES ODE-PROTECTED USE(S) OR INDICATION(S) WITH THAT DRUG(S). AN APPLICATION SEEKING APPROVAL FOR THE SAME ACTIVE MOIETY OR MOIETIES, INCLUDING AN ANDA THAT CITES THIS NDA AS ITS BASIS OF SUBMISSION, MAY NOT BE APPROVED FOR SUCH ODE-PROTECTED USE(S) AND INDICATION(S)
EQ 1MG BASE ASTAGRAF XL ASTELLAS N204096 July 19, 2013 RX CAPSULE, EXTENDED RELEASE ORAL May 24, 2025 FDA HAS NOT RECOGNIZED ORPHAN-DRUG EXCLUSIVITY (ODE) FOR THIS DRUG, BUT IT CONTAINS THE SAME ACTIVE MOIETY OR MOIETIES AS ANOTHER DRUG(S) THAT WAS ELIGIBLE FOR ODE, AND ALSO SHARES ODE-PROTECTED USE(S) OR INDICATION(S) WITH THAT DRUG(S). AN APPLICATION SEEKING APPROVAL FOR THE SAME ACTIVE MOIETY OR MOIETIES, INCLUDING AN ANDA THAT CITES THIS NDA AS ITS BASIS OF SUBMISSION, MAY NOT BE APPROVED FOR SUCH ODE-PROTECTED USE(S) AND INDICATION(S)
EQ 5MG BASE ASTAGRAF XL ASTELLAS N204096 July 19, 2013 RX CAPSULE, EXTENDED RELEASE ORAL May 24, 2025 FDA HAS NOT RECOGNIZED ORPHAN-DRUG EXCLUSIVITY (ODE) FOR THIS DRUG, BUT IT CONTAINS THE SAME ACTIVE MOIETY OR MOIETIES AS ANOTHER DRUG(S) THAT WAS ELIGIBLE FOR ODE, AND ALSO SHARES ODE-PROTECTED USE(S) OR INDICATION(S) WITH THAT DRUG(S). AN APPLICATION SEEKING APPROVAL FOR THE SAME ACTIVE MOIETY OR MOIETIES, INCLUDING AN ANDA THAT CITES THIS NDA AS ITS BASIS OF SUBMISSION, MAY NOT BE APPROVED FOR SUCH ODE-PROTECTED USE(S) AND INDICATION(S)
EQ 0.2MG BASE/PACKET PROGRAF ASTELLAS N210115 May 24, 2018 RX FOR SUSPENSION ORAL May 24, 2025 PROPHYLAXIS OF ORGAN REJECTION IN PEDIATRIC PATIENTS RECEIVING ALLOGENEIC KIDNEY TRANSPLANT, LIVER TRANSPLANTS, AND HEART TRANSPLANT, IN COMBINULLTION WITH OTHER IMMUNOSUPPRESSANTS
EQ 1MG BASE/PACKET PROGRAF ASTELLAS N210115 May 24, 2018 RX FOR SUSPENSION ORAL May 24, 2025 PROPHYLAXIS OF ORGAN REJECTION IN PEDIATRIC PATIENTS RECEIVING ALLOGENEIC KIDNEY TRANSPLANT, LIVER TRANSPLANTS, AND HEART TRANSPLANT, IN COMBINULLTION WITH OTHER IMMUNOSUPPRESSANTS

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Peptidyl-prolyl cis-trans isomerase FKBP1A Enzyme INHIBITOR Kd 9.40 WOMBAT-PK CHEMBL
Cytochrome P450 3A4 Enzyme IC50 6 DRUG MATRIX
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform Enzyme Ki 7.46 WOMBAT-PK
Interleukin-2 Cytokine IC50 9.72 WOMBAT-PK
Interferon gamma Cytokine IC50 10.22 WOMBAT-PK
Interleukin-5 Cytokine IC50 10.22 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6 WOMBAT-PK
Peptidyl-prolyl cis-trans isomerase FKBP10 Enzyme IC50 9.02 WOMBAT-PK
Serine/threonine-protein kinase mTOR Kinase IC50 9.02 CHEMBL
Splicing factor 3B subunit 3 Unclassified IC50 7.96 CHEMBL
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Enzyme Kd 7.70 CHEMBL
Peptidyl-prolyl cis-trans isomerase FKBP5 Enzyme Ki 7.10 CHEMBL
Peptidyl-prolyl cis-trans isomerase FKBP1B Enzyme Kd 9.40 CHEMBL

External reference:

IDSource
4020868 VUID
N0000148372 NUI
D00107 KEGG_DRUG
109581-93-3 SECONDARY_CAS_RN
4020868 VANDF
C0771204 UMLSCUI
CHEBI:61049 CHEBI
CHEMBL269732 ChEMBL_ID
CHEMBL3989887 ChEMBL_ID
DB00864 DRUGBANK_ID
D016559 MESH_DESCRIPTOR_UI
445643 PUBCHEM_CID
6878 INN_ID
WM0HAQ4WNM UNII
6784 IUPHAR_LIGAND_ID
235991 RXNORM
133309 MMSL
5539 MMSL
66434 MMSL
d03752 MMSL
004446 NDDF
004447 NDDF
109129008 SNOMEDCT_US
386975001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0168-0416 OINTMENT 1 mg TOPICAL ANDA 26 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0168-0417 OINTMENT 0.30 mg TOPICAL ANDA 26 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0378-2045 CAPSULE 0.50 mg ORAL ANDA 30 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0378-2046 CAPSULE 1 mg ORAL ANDA 30 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0378-2047 CAPSULE 5 mg ORAL ANDA 30 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-0607 CAPSULE, GELATIN COATED 0.50 mg ORAL NDA 30 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-0617 CAPSULE, GELATIN COATED 1 mg ORAL NDA 30 sections
ASTAGRAF XL HUMAN PRESCRIPTION DRUG LABEL 1 0469-0647 CAPSULE, COATED, EXTENDED RELEASE 0.50 mg ORAL NDA 27 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-0657 CAPSULE, GELATIN COATED 5 mg ORAL NDA 30 sections
ASTAGRAF XL HUMAN PRESCRIPTION DRUG LABEL 1 0469-0677 CAPSULE, COATED, EXTENDED RELEASE 1 mg ORAL NDA 27 sections
ASTAGRAF XL HUMAN PRESCRIPTION DRUG LABEL 1 0469-0687 CAPSULE, COATED, EXTENDED RELEASE 5 mg ORAL NDA 27 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-1230 GRANULE, FOR SUSPENSION 0.20 mg ORAL NDA 30 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-1330 GRANULE, FOR SUSPENSION 1 mg ORAL NDA 30 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-3016 INJECTION, SOLUTION 5 mg INTRAVENOUS NDA 30 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0781-2102 CAPSULE 0.50 mg ORAL ANDA 29 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0781-2103 CAPSULE 1 mg ORAL ANDA 29 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0781-2104 CAPSULE 5 mg ORAL ANDA 29 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0904-6425 CAPSULE 1 mg ORAL ANDA 26 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0904-6623 CAPSULE 0.50 mg ORAL ANDA 26 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0904-6624 CAPSULE 5 mg ORAL ANDA 26 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0904-7097 CAPSULE 1 mg ORAL ANDA 26 sections
tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 16714-098 CAPSULE 0.50 mg ORAL ANDA 29 sections
tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 16714-099 CAPSULE 1 mg ORAL ANDA 29 sections
tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 16714-100 CAPSULE 5 mg ORAL ANDA 29 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 16729-041 CAPSULE 0.50 mg ORAL ANDA 29 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 16729-042 CAPSULE 1 mg ORAL ANDA 29 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 16729-043 CAPSULE 5 mg ORAL ANDA 29 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 16729-421 OINTMENT 0.30 mg TOPICAL ANDA 25 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 16729-422 OINTMENT 1 mg TOPICAL ANDA 25 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 21695-170 CAPSULE, GELATIN COATED 1 mg ORAL NDA 24 sections