tacrolimus 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
immunosuppressants, rapamycin derivatives 2552 104987-11-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • FK-506
  • tacrolimus hydrate
  • tacrolimus
  • fujimycin
  • tsukubaenolide
  • anhydrous tacrolimus
  • tacrolimus anhydrous
  • modigraf
  • FR900506
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
  • Molecular weight: 804.03
  • Formula: C44H69NO12
  • CLOGP: 5.78
  • LIPINSKI: 3
  • HAC: 13
  • HDO: 3
  • TPSA: 178.36
  • ALOGS: -5.30
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
5 mg O
5 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.24 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 25 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 26 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 8, 1994 FDA ASTELLAS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Transplant rejection 3507.98 10.72 1169 114190 8440 50481325
Cytomegalovirus infection 2460.59 10.72 1068 114291 16894 50472871
Post transplant lymphoproliferative disorder 2127.74 10.72 656 114703 3548 50486217
Thrombotic microangiopathy 1745.57 10.72 682 114677 8109 50481656
Kidney transplant rejection 1319.84 10.72 451 114908 3536 50486229
Transplant dysfunction 1211.40 10.72 441 114918 4243 50485522
Immunosuppressant drug level increased 1176.09 10.72 388 114971 2694 50487071
Epstein-Barr virus infection 1099.85 10.72 459 114900 6538 50483227
Product use in unapproved indication 1004.36 10.72 1277 114082 114542 50375223
Cytomegalovirus viraemia 936.96 10.72 366 114993 4343 50485422
Polyomavirus-associated nephropathy 930.35 10.72 276 115083 1276 50488489
BK virus infection 857.26 10.72 301 115058 2580 50487185
Liver transplant rejection 802.87 10.72 237 115122 1073 50488692
Complications of transplanted kidney 798.83 10.72 266 115093 1907 50487858
Posterior reversible encephalopathy syndrome 785.72 10.72 465 114894 14463 50475302
Acute graft versus host disease 701.49 10.72 283 115076 3675 50486090
Graft versus host disease 691.42 10.72 319 115040 5847 50483918
Fatigue 643.67 10.72 413 114946 707188 49782577
Renal impairment 572.64 10.72 781 114578 74880 50414885
Chronic graft versus host disease 525.38 10.72 210 115149 2657 50487108
Off label use 509.81 10.72 2282 113077 472144 50017621
Bronchopulmonary aspergillosis 497.63 10.72 273 115086 7319 50482446
Acute graft versus host disease in skin 494.51 10.72 204 115155 2814 50486951
Multiple organ dysfunction syndrome 491.79 10.72 590 114769 49747 50440018
Pneumocystis jirovecii pneumonia 466.32 10.72 333 115026 14330 50475435
Aspergillus infection 460.15 10.72 250 115109 6571 50483194
Drug level increased 458.62 10.72 368 114991 18900 50470865
Ovarian cyst 452.35 10.72 321 115038 13675 50476090
Transplant failure 423.57 10.72 149 115210 1284 50488481
Immunosuppressant drug level decreased 415.09 10.72 130 115229 745 50489020
Nephropathy toxic 411.70 10.72 246 115113 7783 50481982
Arthralgia 401.77 10.72 253 115106 438449 50051316
COVID-19 396.50 10.72 510 114849 46152 50443613
Smooth muscle cell neoplasm 388.65 10.72 120 115239 651 50489114
Nocardiosis 387.96 10.72 146 115213 1552 50488213
Epstein-Barr virus associated lymphoproliferative disorder 385.08 10.72 145 115214 1544 50488221
Trichodysplasia spinulosa 379.76 10.72 107 115252 395 50489370
Delayed graft function 378.66 10.72 123 115236 807 50488958
Pain 368.63 10.72 469 114890 578434 49911331
Premature delivery 366.34 10.72 354 115005 23309 50466456
Joint swelling 366.31 10.72 60 115299 245226 50244539
Diffuse large B-cell lymphoma 363.91 10.72 201 115158 5461 50484304
Adenovirus infection 358.59 10.72 165 115194 3003 50486762
Drug hypersensitivity 358.34 10.72 69 115290 250941 50238824
Klebsiella infection 342.03 10.72 210 115149 6984 50482781
Fall 336.68 10.72 172 115187 334760 50155005
Graft versus host disease in gastrointestinal tract 334.17 10.72 151 115208 2630 50487135
Acne 329.73 10.72 307 115052 19288 50470477
Cytomegalovirus infection reactivation 326.15 10.72 146 115213 2485 50487280
Drug interaction 323.35 10.72 1095 114264 198526 50291239
Blood creatinine increased 322.20 10.72 603 114756 75557 50414208
Chronic allograft nephropathy 315.85 10.72 99 115260 569 50489196
Renal transplant failure 311.49 10.72 96 115263 517 50489248
Escherichia infection 308.31 10.72 231 115128 10710 50479055
Mucormycosis 305.29 10.72 137 115222 2346 50487419
Arthropathy 304.31 10.72 13 115346 157893 50331872
Acute kidney injury 301.60 10.72 1171 114188 226887 50262878
Dyspnoea 298.86 10.72 494 114865 547114 49942651
Haemophagocytic lymphohistiocytosis 297.58 10.72 206 115153 8427 50481338
Graft versus host disease in skin 295.18 10.72 135 115224 2421 50487344
Enterococcal infection 294.32 10.72 188 115171 6710 50483055
Dizziness 292.44 10.72 218 115141 346151 50143614
Haemolytic uraemic syndrome 291.67 10.72 130 115229 2189 50487576
Septic shock 283.19 10.72 485 114874 56690 50433075
Aplasia pure red cell 277.40 10.72 152 115207 4063 50485702
Contraindicated product administered 272.11 10.72 17 115342 148941 50340824
Completed suicide 271.55 10.72 6 115353 131883 50357882
Leukopenia 257.81 10.72 512 114847 67016 50422749
Swelling 257.09 10.72 70 115289 200802 50288963
Strongyloidiasis 256.49 10.72 90 115269 769 50488996
JC virus infection 255.03 10.72 110 115249 1705 50488060
Peripheral swelling 252.12 10.72 78 115281 205858 50283907
Parvovirus B19 infection 250.56 10.72 77 115282 410 50489355
Hypersensitivity 250.28 10.72 89 115270 215072 50274693
Kidney fibrosis 248.82 10.72 104 115255 1485 50488280
Phaeohyphomycosis 246.91 10.72 65 115294 172 50489593
Pemphigus 245.31 10.72 6 115353 120160 50369605
Nausea 241.24 10.72 816 114543 704582 49785183
Post transplant distal limb syndrome 240.62 10.72 61 115298 131 50489634
Infusion related reaction 238.89 10.72 48 115311 169509 50320256
Cytomegalovirus test positive 238.30 10.72 117 115242 2475 50487290
Respiratory failure 238.23 10.72 594 114765 90587 50399178
Graft loss 238.20 10.72 69 115290 288 50489477
Pseudomonas infection 234.82 10.72 185 115174 9245 50480520
Synovitis 232.78 10.72 12 115347 123853 50365912
Rash 232.48 10.72 401 114958 437070 50052695
Pain in extremity 228.51 10.72 173 115186 272692 50217073
Abdominal discomfort 228.01 10.72 122 115237 231519 50258246
Glossodynia 227.78 10.72 8 115351 115561 50374204
Sepsis 221.89 10.72 737 114622 132188 50357577
Epstein-Barr viraemia 220.95 10.72 81 115278 795 50488970
Human herpesvirus 6 infection 219.97 10.72 111 115248 2495 50487270
Acute graft versus host disease in intestine 219.42 10.72 96 115263 1543 50488222
Heart transplant rejection 217.65 10.72 68 115291 386 50489379
Exposure during pregnancy 215.52 10.72 686 114673 120329 50369436
Lymphoproliferative disorder 212.44 10.72 112 115247 2765 50487000
Headache 207.47 10.72 538 114821 505997 49983768
Lymphocele 206.33 10.72 75 115284 717 50489048
Viraemia 201.33 10.72 80 115279 995 50488770
Lung transplant rejection 201.00 10.72 73 115286 696 50489069
Human polyomavirus infection 196.95 10.72 57 115302 237 50489528
Histoplasmosis disseminated 194.12 10.72 82 115277 1204 50488561
Renal tubular necrosis 190.02 10.72 169 115190 9999 50479766
Focal segmental glomerulosclerosis 187.52 10.72 81 115278 1260 50488505
Venoocclusive liver disease 183.94 10.72 117 115242 4144 50485621
Bacteraemia 183.24 10.72 194 115165 14239 50475526
Varicella zoster virus infection 181.24 10.72 96 115263 2393 50487372
Sinusitis 181.16 10.72 81 115278 170477 50319288
Therapeutic product effect decreased 180.52 10.72 44 115315 136006 50353759
Malaise 179.46 10.72 306 115053 335226 50154539
Systemic mycosis 179.20 10.72 74 115285 1023 50488742
Polyomavirus viraemia 179.09 10.72 59 115300 407 50489358
Diabetes mellitus 176.63 10.72 363 114996 48670 50441095
Wound 169.12 10.72 21 115338 105773 50383992
Pathogen resistance 168.98 10.72 124 115235 5565 50484200
Chronic graft versus host disease in skin 167.92 10.72 62 115297 622 50489143
Cystitis haemorrhagic 165.68 10.72 104 115255 3598 50486167
Renal transplant 158.65 10.72 70 115289 1149 50488616
West Nile viral infection 157.86 10.72 51 115308 328 50489437
Injection site pain 155.13 10.72 32 115327 110992 50378773
Toxoplasmosis 154.75 10.72 72 115287 1345 50488420
Ureaplasma infection 153.62 10.72 54 115305 464 50489301
Product dose omission issue 153.19 10.72 117 115242 183721 50306044
Pneumonia cytomegaloviral 153.15 10.72 79 115280 1862 50487903
Renal failure 150.86 10.72 560 114799 106073 50383692
Anxiety 149.32 10.72 112 115247 177494 50312271
Pancytopenia 147.36 10.72 474 114885 83556 50406209
Nasopharyngitis 146.95 10.72 134 115225 192793 50296972
Asthenia 145.29 10.72 320 115039 318722 50171043
Discomfort 143.86 10.72 35 115324 108345 50381420
Systemic candida 141.76 10.72 85 115274 2705 50487060
Back pain 141.72 10.72 176 115183 219854 50269911
Tubulointerstitial nephritis 139.82 10.72 173 115186 15038 50474727
Pancreas transplant rejection 139.72 10.72 37 115322 101 50489664
Candida infection 138.69 10.72 216 115143 23307 50466458
Proteinuria 138.68 10.72 180 115179 16417 50473348
Cryptococcosis 138.64 10.72 58 115301 830 50488935
Pyelonephritis 138.62 10.72 171 115188 14818 50474947
Drug resistance 137.39 10.72 192 115167 18797 50470968
Acute graft versus host disease in liver 134.11 10.72 51 115308 559 50489206
Contusion 132.74 10.72 45 115314 112138 50377627
Infection reactivation 132.74 10.72 58 115301 929 50488836
Systemic lupus erythematosus 132.57 10.72 78 115281 140544 50349221
Malacoplakia 131.98 10.72 34 115325 80 50489685
Progressive multifocal leukoencephalopathy 131.45 10.72 146 115213 11311 50478454
Complications of transplanted liver 130.61 10.72 44 115315 328 50489437
Mycobacterial infection 128.93 10.72 66 115293 1530 50488235
Feeling abnormal 127.96 10.72 63 115296 125429 50364336
Infective aneurysm 127.59 10.72 44 115315 355 50489410
Cytomegalovirus enteritis 125.62 10.72 38 115321 190 50489575
Constipation 125.48 10.72 143 115216 185565 50304200
Drug level decreased 124.89 10.72 110 115249 6423 50483342
Weight increased 124.31 10.72 167 115192 201724 50288041
Cytomegalovirus colitis 122.70 10.72 68 115291 1859 50487906
Hepatitis C 121.42 10.72 96 115263 4821 50484944
Cholangitis 120.87 10.72 93 115266 4486 50485279
Scedosporium infection 120.38 10.72 43 115316 389 50489376
Somnolence 119.96 10.72 106 115253 154879 50334886
Insomnia 118.84 10.72 134 115225 174731 50315034
Renal tubular atrophy 118.60 10.72 46 115313 534 50489231
Syncope 117.28 10.72 44 115315 102958 50386807
Pneumatosis intestinalis 117.16 10.72 68 115291 2035 50487730
Escherichia bacteraemia 116.03 10.72 78 115281 3038 50486727
Musculoskeletal stiffness 114.56 10.72 76 115283 128405 50361360
Herpes simplex 114.31 10.72 109 115250 7053 50482712
Viral haemorrhagic cystitis 114.05 10.72 47 115312 646 50489119
Brain abscess 113.49 10.72 63 115296 1728 50488037
Haemolytic anaemia 112.83 10.72 122 115237 9170 50480595
Pre-eclampsia 112.69 10.72 114 115245 7930 50481835
Alternaria infection 112.12 10.72 35 115324 198 50489567
Drug abuse 111.75 10.72 6 115353 59840 50429925
Epstein-Barr virus infection reactivation 111.66 10.72 43 115316 489 50489276
Depression 111.07 10.72 128 115231 165295 50324470
Atypical haemolytic uraemic syndrome 109.74 10.72 43 115316 514 50489251
Obliterative bronchiolitis 108.79 10.72 62 115297 1791 50487974
Hepatitis E 108.59 10.72 54 115305 1175 50488590
Cryptosporidiosis infection 108.57 10.72 36 115323 254 50489511
Pericarditis 105.22 10.72 25 115334 78664 50411101
Chest pain 104.18 10.72 151 115208 176731 50313034
Human herpesvirus 8 infection 104.08 10.72 33 115326 198 50489567
Hepatosplenic T-cell lymphoma 104.03 10.72 42 115317 546 50489219
Meningitis cryptococcal 103.21 10.72 51 115308 1094 50488671
End stage renal disease 102.54 10.72 93 115266 5644 50484121
Shock haemorrhagic 102.10 10.72 110 115249 8234 50481531
Abortion spontaneous 100.56 10.72 264 115095 41508 50448257
Chest discomfort 98.44 10.72 44 115315 92678 50397087
Renal graft infection 97.91 10.72 29 115330 133 50489632
Injection site erythema 97.87 10.72 25 115334 74911 50414854
Chronic obstructive pulmonary disease 97.80 10.72 6 115353 53429 50436336
Drug intolerance 97.79 10.72 222 115137 218882 50270883
Mycobacterium abscessus infection 97.65 10.72 39 115320 492 50489273
Hypogammaglobulinaemia 97.21 10.72 90 115269 5609 50484156
Enterobacter infection 97.17 10.72 58 115301 1830 50487935
Lower respiratory tract infection 96.72 10.72 48 115311 95153 50394612
Acute myeloid leukaemia recurrent 96.67 10.72 52 115307 1338 50488427
Intentional overdose 96.07 10.72 14 115345 62490 50427275
Polyomavirus test positive 95.84 10.72 25 115334 63 50489702
Acute respiratory distress syndrome 95.34 10.72 172 115187 20927 50468838
Escherichia urinary tract infection 95.17 10.72 118 115241 10277 50479488
Confusional state 93.43 10.72 176 115183 185752 50304013
New onset diabetes after transplantation 93.42 10.72 25 115334 72 50489693
Complications of transplant surgery 92.89 10.72 28 115331 138 50489627
Nephrotic syndrome 92.55 10.72 81 115278 4689 50485076
Muscle spasms 91.10 10.72 91 115268 125462 50364303
Cytomegalovirus chorioretinitis 90.03 10.72 51 115308 1456 50488309
Encephalitis viral 89.93 10.72 52 115307 1545 50488220
Helicobacter infection 89.72 10.72 6 115353 49696 50440069
Mobility decreased 89.59 10.72 35 115324 79913 50409852
Cytomegalovirus gastrointestinal infection 88.53 10.72 31 115328 263 50489502
Pruritus 88.38 10.72 340 115019 283228 50206537
Irritable bowel syndrome 87.84 10.72 8 115351 51433 50438332
Gait disturbance 87.39 10.72 129 115230 149876 50339889
Hyperammonaemia 85.26 10.72 77 115282 4647 50485118
Pneumonia fungal 85.11 10.72 74 115285 4246 50485519
Urticaria 85.07 10.72 102 115257 129459 50360306
Liver abscess 84.98 10.72 60 115299 2533 50487232
Asthma 84.95 10.72 49 115310 89288 50400477
Human ehrlichiosis 84.05 10.72 26 115333 142 50489623
Renal tubular injury 83.16 10.72 32 115327 363 50489402
Flushing 82.59 10.72 25 115334 66990 50422775
Injection site reaction 82.25 10.72 9 115350 50023 50439742
Hepatic failure 81.78 10.72 208 115151 32075 50457690
Mycobacterium avium complex infection 81.66 10.72 58 115301 2472 50487293
Cytomegalovirus enterocolitis 81.64 10.72 35 115324 534 50489231
Donor specific antibody present 81.22 10.72 24 115335 109 50489656
Hyperhidrosis 80.91 10.72 52 115307 89374 50400391
Encapsulating peritoneal sclerosis 80.63 10.72 30 115329 308 50489457
Balance disorder 80.60 10.72 30 115329 70560 50419205
Mycoplasma infection 79.08 10.72 31 115328 371 50489394
Graft versus host disease in lung 78.95 10.72 30 115329 328 50489437
Immune reconstitution inflammatory syndrome 78.78 10.72 79 115280 5437 50484328
Heart rate increased 78.39 10.72 39 115320 77211 50412554
Staphylococcal infection 77.60 10.72 217 115142 35399 50454366
Hypoaesthesia 77.52 10.72 106 115253 127151 50362614
Disease recurrence 77.45 10.72 153 115206 19928 50469837
Fibromyalgia 76.78 10.72 7 115352 44971 50444794
Complications of transplanted lung 76.59 10.72 26 115333 199 50489566
Rheumatoid arthritis 75.95 10.72 224 115135 202326 50287439
Alveolar proteinosis 74.87 10.72 28 115331 292 50489473
Glomerulonephritis membranoproliferative 74.87 10.72 24 115335 150 50489615
Cerebral aspergillosis 74.67 10.72 29 115330 338 50489427
MELAS syndrome 74.62 10.72 22 115337 99 50489666
Pulmonary nocardiosis 74.60 10.72 24 115335 152 50489613
Rhodococcus infection 74.42 10.72 21 115338 78 50489687
Anti-erythropoietin antibody negative 74.22 10.72 21 115338 79 50489686
Autoimmune haemolytic anaemia 73.79 10.72 66 115293 3933 50485832
Arthritis 73.70 10.72 54 115305 86667 50403098
Drug ineffective for unapproved indication 73.61 10.72 155 115204 21126 50468639
Drug level fluctuating 73.17 10.72 29 115330 358 50489407
Cerebrovascular accident 72.92 10.72 65 115294 94615 50395150
Hepatic enzyme increased 72.60 10.72 126 115233 137254 50352511
Babesiosis 72.25 10.72 25 115334 204 50489561
Infection in an immunocompromised host 71.54 10.72 30 115329 432 50489333
Leukoencephalopathy 71.48 10.72 64 115295 3819 50485946
Squamous cell carcinoma 71.09 10.72 88 115271 7651 50482114
Bone marrow failure 71.03 10.72 179 115180 27445 50462320
Hydronephrosis 70.36 10.72 92 115267 8449 50481316
Weight decreased 70.36 10.72 263 115096 220982 50268783
Histoplasmosis 70.25 10.72 46 115313 1713 50488052
Encephalopathy 70.14 10.72 202 115157 33509 50456256
Encephalitis cytomegalovirus 70.14 10.72 31 115328 511 50489254
Musculoskeletal pain 69.46 10.72 39 115320 72138 50417627
Paraesthesia 69.44 10.72 104 115255 120139 50369626
Lung transplant 69.42 10.72 55 115304 2770 50486995
Bacterial sepsis 69.41 10.72 61 115298 3551 50486214
Angiosarcoma 68.81 10.72 24 115335 201 50489564
Squamous cell carcinoma of skin 68.21 10.72 71 115288 5107 50484658
Gastroenteritis norovirus 68.10 10.72 45 115314 1702 50488063
Glomerulonephritis 67.77 10.72 43 115316 1516 50488249
Organising pneumonia 67.50 10.72 68 115291 4706 50485059
Liver function test abnormal 66.98 10.72 238 115121 44101 50445664
Pneumonia bacterial 66.96 10.72 83 115276 7226 50482539
Adenoviral hepatitis 66.53 10.72 24 115335 224 50489541
Engraftment syndrome 66.41 10.72 26 115333 310 50489455
Pleural mesothelioma malignant 66.29 10.72 17 115342 39 50489726
Dysplasia 65.94 10.72 32 115327 659 50489106
Urinary tract infection bacterial 65.81 10.72 63 115296 4096 50485669
Knee arthroplasty 65.67 10.72 4 115355 35842 50453923
Disseminated intravascular coagulation 65.41 10.72 130 115229 17005 50472760
Microtia 65.17 10.72 26 115333 327 50489438
Neurotoxicity 65.12 10.72 119 115240 14621 50475144
Anogenital warts 64.88 10.72 27 115332 381 50489384
Psoriatic arthropathy 64.75 10.72 14 115345 47018 50442747
Dermatophytosis 64.48 10.72 21 115338 139 50489626
Intestine transplant rejection 64.21 10.72 16 115343 31 50489734
Cleft palate 64.12 10.72 35 115324 928 50488837
Chronic myeloid leukaemia 64.04 10.72 47 115312 2109 50487656
Chronic graft versus host disease in liver 63.86 10.72 24 115335 254 50489511
Thrombotic thrombocytopenic purpura 63.85 10.72 58 115301 3527 50486238
Osteoarthritis 63.29 10.72 39 115320 68567 50421198
Oesophageal candidiasis 63.15 10.72 67 115292 4927 50484838
Graft versus host disease in liver 63.11 10.72 28 115331 466 50489299
Cough 63.08 10.72 309 115050 240955 50248810
Blister 62.99 10.72 61 115298 85357 50404408
Malacoplakia gastrointestinal 62.77 10.72 17 115342 52 50489713
Disseminated cryptococcosis 62.66 10.72 26 115333 364 50489401
Venoocclusive disease 62.43 10.72 44 115315 1852 50487913
Peritonitis 62.16 10.72 120 115239 15366 50474399
Memory impairment 61.69 10.72 54 115305 79306 50410459
Hepatitis B 61.58 10.72 56 115303 3410 50486355
Hyperuricaemia 61.34 10.72 64 115295 4616 50485149
Pulmonary mucormycosis 61.11 10.72 22 115337 204 50489561
Dry mouth 60.65 10.72 26 115333 56152 50433613
Bacterial pyelonephritis 60.00 10.72 24 115335 304 50489461
Impaired healing 59.89 10.72 43 115316 69743 50420022
Influenza like illness 59.83 10.72 28 115331 57431 50432334
Epstein-Barr virus test positive 59.70 10.72 28 115331 533 50489232
Passenger lymphocyte syndrome 59.56 10.72 16 115343 47 50489718
Ill-defined disorder 59.48 10.72 25 115334 54629 50435136
Papilloma viral infection 59.19 10.72 37 115322 1270 50488495
Ascites 58.96 10.72 198 115161 35663 50454102
Hepatic artery thrombosis 58.58 10.72 16 115343 51 50489714
Renal tubular acidosis 58.56 10.72 39 115320 1495 50488270
Actinic keratosis 58.27 10.72 45 115314 2182 50487583
Palpitations 58.27 10.72 78 115281 94428 50395337
Pulmonary alveolar haemorrhage 58.11 10.72 58 115301 3969 50485796
Therapeutic product effect incomplete 58.00 10.72 74 115285 91441 50398324
Osmotic demyelination syndrome 57.90 10.72 28 115331 572 50489193
Wrong technique in product usage process 57.88 10.72 27 115332 55483 50434282
Vomiting 57.80 10.72 723 114636 460035 50029730
Drug level above therapeutic 57.57 10.72 57 115302 3863 50485902
Malignant neoplasm progression 57.13 10.72 43 115316 68081 50421684
Encephalitis 56.96 10.72 77 115282 7303 50482462
Blood pressure increased 56.85 10.72 138 115221 132994 50356771
Decreased appetite 56.85 10.72 250 115109 200673 50289092
Cerebral toxoplasmosis 56.74 10.72 29 115330 670 50489095
Lymphopenia 56.63 10.72 116 115243 15505 50474260
Coccidioidomycosis 56.48 10.72 31 115328 831 50488934
IgA nephropathy 56.35 10.72 25 115334 416 50489349
Wheezing 56.23 10.72 36 115323 62011 50427754
Limb reduction defect 56.17 10.72 24 115335 363 50489402
Microangiopathic haemolytic anaemia 56.15 10.72 26 115333 480 50489285
Adenoviral haemorrhagic cystitis 56.13 10.72 19 115340 144 50489621
Disseminated toxoplasmosis 55.87 10.72 17 115342 87 50489678
Complications of transplanted heart 55.85 10.72 15 115344 44 50489721
Skin papilloma 55.73 10.72 58 115301 4171 50485594
Stenotrophomonas infection 55.58 10.72 39 115320 1630 50488135
Nodular melanoma 55.35 10.72 15 115344 46 50489719
Upper respiratory fungal infection 55.35 10.72 19 115340 151 50489614
Graft complication 55.13 10.72 20 115339 190 50489575
Glomerulosclerosis 54.86 10.72 23 115336 331 50489434
Loss of consciousness 54.86 10.72 96 115263 104257 50385508
Malacoplakia vesicae 54.64 10.72 15 115344 49 50489716
Injection site swelling 54.41 10.72 14 115345 41759 50448006
Haemodialysis 53.83 10.72 80 115279 8282 50481483
Cardiac failure congestive 53.71 10.72 68 115291 84314 50405451
Brain oedema 53.55 10.72 99 115260 12271 50477494
Nephropathy 53.54 10.72 63 115296 5195 50484570
Cytomegalovirus gastritis 53.47 10.72 19 115340 169 50489596
Myocardial infarction 53.36 10.72 75 115284 88952 50400813
Folliculitis 53.34 10.72 12 115347 39213 50450552
Renal artery stenosis 53.20 10.72 38 115321 1634 50488131
Dysmorphism 52.84 10.72 42 115317 2125 50487640
Rash pruritic 51.88 10.72 22 115337 47824 50441941
Prophylaxis against transplant rejection 51.79 10.72 12 115347 14 50489751
Pain in jaw 51.77 10.72 12 115347 38416 50451349
Acanthamoeba infection 51.57 10.72 13 115346 27 50489738
Parainfluenzae virus infection 51.51 10.72 39 115320 1836 50487929
Hyperglycaemia 51.25 10.72 191 115168 36214 50453551
Escherichia sepsis 51.15 10.72 56 115303 4268 50485497
Bradycardia 51.09 10.72 43 115316 64383 50425382
Visceral leishmaniasis 50.74 10.72 24 115335 466 50489299
Device expulsion 50.52 10.72 4 115355 28818 50460947
Pregnancy 50.13 10.72 165 115194 29412 50460353
Hypotension 49.91 10.72 323 115036 235146 50254619
Enterocolitis 49.90 10.72 68 115291 6499 50483266
Clostridium difficile colitis 49.90 10.72 119 115240 17623 50472142
Myalgia 49.88 10.72 133 115226 124186 50365579
Vertigo 49.88 10.72 28 115331 51804 50437961
Ureteric stenosis 49.86 10.72 25 115334 554 50489211
Penicillium infection 49.78 10.72 16 115343 101 50489664
Coronavirus infection 49.46 10.72 46 115313 2883 50486882
Cytomegalovirus gastroenteritis 49.43 10.72 18 115341 173 50489592
Neck pain 49.18 10.72 35 115324 57032 50432733
BK polyomavirus test positive 48.95 10.72 13 115346 36 50489729
Hip arthroplasty 48.70 10.72 6 115353 30423 50459342
Epstein-Barr virus associated lymphoma 48.65 10.72 23 115336 446 50489319
Microsporidia infection 48.65 10.72 19 115340 225 50489540
Injection site bruising 48.51 10.72 12 115347 36756 50453009
Premature baby 48.38 10.72 120 115239 18217 50471548
Abdominal pain upper 48.28 10.72 193 115166 159116 50330649
Graft thrombosis 48.17 10.72 17 115342 148 50489617
Injection site pruritus 48.14 10.72 16 115343 40395 50449370
Subarachnoid haemorrhage 47.60 10.72 87 115272 10689 50479076
Blood cholesterol increased 47.40 10.72 34 115325 55181 50434584
Chronic kidney disease 47.38 10.72 198 115161 39573 50450192
Neuropathy peripheral 47.32 10.72 93 115266 96664 50393101
Sarcoma of skin 47.26 10.72 12 115347 26 50489739
Cytomegalovirus hepatitis 47.14 10.72 20 115339 297 50489468
Dysgeusia 47.08 10.72 15 115344 38901 50450864
Drug reaction with eosinophilia and systemic symptoms 47.00 10.72 5 115354 28419 50461346
Emphysematous pyelonephritis 46.91 10.72 17 115342 161 50489604
Central nervous system viral infection 46.89 10.72 15 115344 93 50489672
Hot flush 46.80 10.72 21 115338 44148 50445617
Trichophytosis 46.78 10.72 13 115346 45 50489720
Pyelonephritis acute 46.78 10.72 52 115307 4031 50485734
Toxicity to various agents 46.47 10.72 711 114648 211788 50277977
Adverse event 46.07 10.72 21 115338 43742 50446023
Transplantation associated food allergy 45.78 10.72 9 115350 0 50489765
Disseminated mucormycosis 45.77 10.72 16 115343 135 50489630
Biliary anastomosis complication 45.71 10.72 11 115348 17 50489748
Pseudomonal bacteraemia 45.64 10.72 31 115328 1228 50488537
Hepatic function abnormal 45.62 10.72 171 115188 32510 50457255
Perinephric collection 45.22 10.72 15 115344 106 50489659
Dermatitis atopic 45.15 10.72 48 115311 3538 50486227
Neutrophil Pelger-Huet anomaly present 45.03 10.72 14 115345 78 50489687
Fungal skin infection 45.02 10.72 49 115310 3710 50486055
Liver transplant 45.01 10.72 38 115321 2094 50487671
Haemorrhage intracranial 44.99 10.72 92 115267 12282 50477483
Human herpesvirus 6 encephalitis 44.96 10.72 16 115343 143 50489622
Injury 44.86 10.72 28 115331 48897 50440868
Low birth weight baby 44.84 10.72 61 115298 5820 50483945
Staphylococcal sepsis 44.84 10.72 67 115292 6969 50482796
Blastomycosis 44.79 10.72 18 115341 231 50489534
Renal tubular disorder 44.53 10.72 40 115319 2397 50487368
Bacterial infection 44.50 10.72 108 115251 16173 50473592
Renal abscess 44.39 10.72 24 115335 624 50489141
Heart rate decreased 44.27 10.72 14 115345 36483 50453282
Feeling hot 44.18 10.72 17 115342 39185 50450580
Central nervous system fungal infection 44.15 10.72 14 115345 84 50489681
Rhinovirus infection 43.96 10.72 47 115312 3487 50486278
Optic neuropathy 43.83 10.72 34 115325 1660 50488105
Throat irritation 43.72 10.72 8 115351 30231 50459534
Fungal infection 43.68 10.72 159 115200 29806 50459959
Orf 43.59 10.72 11 115348 23 50489742
Renal disorder 43.57 10.72 150 115209 27355 50462410
Pneumonia klebsiella 43.30 10.72 36 115323 1942 50487823
Bacillary angiomatosis 43.14 10.72 13 115346 64 50489701
Suicide attempt 42.93 10.72 33 115326 51699 50438066
Epstein Barr virus positive mucocutaneous ulcer 42.91 10.72 20 115339 375 50489390
Complications of bone marrow transplant 42.73 10.72 21 115338 445 50489320
Splenomegaly 42.68 10.72 78 115281 9582 50480183
Ureteral necrosis 42.65 10.72 12 115347 44 50489721
Neutropenia 42.53 10.72 520 114839 147445 50342320
Hepatic necrosis 42.41 10.72 56 115303 5192 50484573
Disseminated cytomegaloviral infection 42.35 10.72 16 115343 172 50489593
Haemolysis 42.28 10.72 60 115299 5956 50483809
Acinetobacter infection 42.14 10.72 31 115328 1396 50488369
Post procedural bile leak 41.95 10.72 14 115345 101 50489664
Gastroenteritis eosinophilic 41.87 10.72 13 115346 72 50489693
Lupus nephritis 41.74 10.72 38 115321 2317 50487448
Locked-in syndrome 41.73 10.72 19 115340 337 50489428
Philadelphia positive chronic myeloid leukaemia 41.54 10.72 11 115348 30 50489735
Renal necrosis 41.44 10.72 12 115347 50 50489715
Anuria 41.35 10.72 84 115275 11160 50478605
Urinary fistula 41.34 10.72 10 115349 16 50489749
Sleep disorder due to general medical condition, insomnia type 40.99 10.72 161 115198 31286 50458479
Proteus infection 40.96 10.72 25 115334 822 50488943
Eczema herpeticum 40.92 10.72 14 115345 110 50489655
Pneumomediastinum 40.88 10.72 28 115331 1125 50488640
Bone pain 40.65 10.72 29 115330 47200 50442565
Disseminated trichosporonosis 40.61 10.72 10 115349 18 50489747
Liver transplant failure 40.61 10.72 10 115349 18 50489747
Epidermodysplasia verruciformis 40.52 10.72 12 115347 55 50489710
Reticulocytopenia 40.52 10.72 12 115347 55 50489710
Thrombocytopenia 40.37 10.72 457 114902 127216 50362549
Cerebral microhaemorrhage 40.32 10.72 13 115346 83 50489682
Meningoencephalitis herpetic 40.31 10.72 27 115332 1045 50488720
Treatment failure 40.28 10.72 169 115190 137468 50352297
Colorectal cancer 40.28 10.72 30 115329 1377 50488388
Bile duct stenosis 40.22 10.72 27 115332 1049 50488716
Drug level below therapeutic 40.07 10.72 46 115313 3694 50486071
Oesophageal ulcer 39.72 10.72 47 115312 3898 50485867
Blood pressure fluctuation 39.60 10.72 16 115343 35807 50453958
Normocytic anaemia 39.58 10.72 29 115330 1298 50488467
Guillain-Barre syndrome 39.35 10.72 44 115315 3433 50486332
Suicidal ideation 39.17 10.72 41 115318 55344 50434421
Erythema 39.11 10.72 186 115173 146228 50343537
Hepatic cyst infection 38.93 10.72 13 115346 94 50489671
Periostitis 38.92 10.72 17 115342 272 50489493
Dysphonia 38.90 10.72 20 115339 38872 50450893
Engraft failure 38.89 10.72 18 115341 332 50489433
Encephalitis autoimmune 38.67 10.72 28 115331 1230 50488535
COVID-19 pneumonia 38.64 10.72 69 115290 8326 50481439
Osteonecrosis of jaw 38.53 10.72 13 115346 32513 50457252
Blood potassium decreased 38.46 10.72 18 115341 36927 50452838
Anorexia nervosa 38.45 10.72 15 115344 177 50489588
Haemodynamic instability 38.29 10.72 67 115292 7957 50481808
Pyelonephritis fungal 38.24 10.72 13 115346 100 50489665
Dyspepsia 38.18 10.72 69 115290 74028 50415737
Trichosporon infection 37.93 10.72 16 115343 234 50489531
Disseminated aspergillosis 37.77 10.72 11 115348 47 50489718
Chronic graft versus host disease in intestine 37.71 10.72 12 115347 73 50489692
Opportunistic infection 37.69 10.72 31 115328 1647 50488118
Chronic graft versus host disease oral 37.68 10.72 13 115346 105 50489660
Oesophageal atresia 37.45 10.72 20 115339 507 50489258
Pancreas transplant 37.36 10.72 9 115350 14 50489751
Interstitial lung disease 37.31 10.72 228 115131 52948 50436817
Myelosuppression 37.30 10.72 90 115269 13427 50476338
Hypertrophic osteoarthropathy 37.07 10.72 10 115349 30 50489735
Oxygen saturation decreased 37.04 10.72 69 115290 73179 50416586
Pneumonia influenzal 36.99 10.72 29 115330 1438 50488327
Urate nephropathy 36.75 10.72 13 115346 114 50489651
Lactic acidosis 36.71 10.72 15 115344 33340 50456425
Sedation 36.67 10.72 12 115347 30598 50459167
Orthostatic hypotension 36.31 10.72 11 115348 29470 50460295
Staphylococcal bacteraemia 36.30 10.72 50 115309 4827 50484938
Candida sepsis 36.24 10.72 27 115332 1240 50488525
Hepatic artery stenosis 36.23 10.72 8 115351 6 50489759
Oropharyngeal pain 36.15 10.72 77 115282 77724 50412041
Pneumocystis jirovecii infection 36.09 10.72 27 115332 1248 50488517
Fungal endocarditis 36.09 10.72 15 115344 211 50489554
Lymphocytic infiltration 35.94 10.72 23 115336 823 50488942
Accidental exposure to product 35.81 10.72 5 115354 23052 50466713
Congenital nail disorder 35.79 10.72 12 115347 88 50489677
Serum sickness 35.67 10.72 36 115323 2496 50487269
Abdominal wall infection 35.67 10.72 12 115347 89 50489676
American trypanosomiasis 35.57 10.72 11 115348 60 50489705
Oesophageal stenosis 35.53 10.72 38 115321 2820 50486945
Device dislocation 35.09 10.72 4 115355 21542 50468223
Food allergy 35.07 10.72 65 115294 8072 50481693
Bronchitis 34.93 10.72 121 115238 104038 50385727
Leiomyosarcoma 34.81 10.72 14 115345 180 50489585
Swollen tongue 34.69 10.72 11 115348 28619 50461146
Genital herpes 34.67 10.72 29 115330 1578 50488187
Steroid withdrawal syndrome 34.66 10.72 19 115340 508 50489257
External auditory canal atresia 34.55 10.72 11 115348 67 50489698
Speech disorder 34.49 10.72 19 115340 35529 50454236
Clostridial infection 34.46 10.72 44 115315 3946 50485819
Enterococcal bacteraemia 34.19 10.72 26 115333 1232 50488533
Pleural effusion 34.12 10.72 309 115050 81145 50408620
Dialysis 34.11 10.72 70 115289 9368 50480397
Tooth disorder 33.78 10.72 7 115352 24221 50465544
Urinary tract infection viral 33.61 10.72 9 115350 26 50489739
Adverse drug reaction 33.60 10.72 46 115313 55176 50434589
Sleep disorder 33.58 10.72 49 115310 57234 50432531
Drug withdrawal syndrome 33.45 10.72 8 115351 25073 50464692
Subcapsular renal haematoma 33.31 10.72 15 115344 259 50489506
Kaposi's sarcoma 33.21 10.72 13 115346 155 50489610
Meningitis bacterial 33.16 10.72 25 115334 1169 50488596
C-reactive protein abnormal 33.14 10.72 11 115348 27798 50461967
Perinephric abscess 32.98 10.72 13 115346 158 50489607
Swelling face 32.83 10.72 43 115316 52552 50437213
Coagulation test abnormal 32.81 10.72 20 115339 656 50489109
Rectal haemorrhage 32.76 10.72 24 115335 38534 50451231
Joint stiffness 32.75 10.72 14 115345 30294 50459471
Pneumonia pseudomonal 32.68 10.72 31 115328 1992 50487773
Stress 32.54 10.72 45 115314 53748 50436017
Post procedural urine leak 32.20 10.72 9 115350 32 50489733
Capillaritis 32.20 10.72 11 115348 86 50489679
Pulmonary haemorrhage 32.01 10.72 55 115304 6437 50483328
Hypoalbuminaemia 32.01 10.72 70 115289 9790 50479975
Gastrooesophageal reflux disease 32.00 10.72 80 115279 76348 50413417
Porokeratosis 31.93 10.72 12 115347 127 50489638
Respiratory distress 31.90 10.72 146 115213 30343 50459422
Subcutaneous abscess 31.84 10.72 47 115312 4835 50484930
Tremor 31.79 10.72 401 114958 114502 50375263
Oedema peripheral 31.77 10.72 220 115139 157741 50332024
Splenic abscess 31.76 10.72 11 115348 90 50489675
Delayed engraftment 31.76 10.72 11 115348 90 50489675
Hypokalaemia 31.72 10.72 99 115260 87893 50401872
Fungal sepsis 31.69 10.72 24 115335 1130 50488635
Vision blurred 31.64 10.72 84 115275 78563 50411202
Diffuse alveolar damage 31.62 10.72 21 115338 801 50488964
Evans syndrome 31.59 10.72 13 115346 178 50489587
Enterovirus infection 31.52 10.72 20 115339 705 50489060
Cholestasis 31.46 10.72 128 115231 25273 50464492
Steroid diabetes 31.38 10.72 22 115337 918 50488847
General physical health deterioration 31.37 10.72 193 115166 142241 50347524
Necrotising fasciitis 31.28 10.72 34 115325 2570 50487195
Treatment noncompliance 31.26 10.72 144 115215 30006 50459759
Nervousness 31.14 10.72 12 115347 27639 50462126
Red blood cell sedimentation rate increased 31.14 10.72 14 115345 29402 50460363
Angiocentric lymphoma 31.03 10.72 18 115341 538 50489227
Vesicoureteric reflux 31.01 10.72 13 115346 187 50489578
Joint injury 31.00 10.72 6 115353 21783 50467982
Klebsiella sepsis 30.98 10.72 24 115335 1169 50488596
Placenta accreta 30.95 10.72 13 115346 188 50489577
Anaphylactic reaction 30.95 10.72 47 115312 54008 50435757
Death 30.82 10.72 539 114820 324840 50164925
Epistaxis 30.81 10.72 62 115297 63892 50425873
Graft ischaemia 30.80 10.72 9 115350 39 50489726
B-cell lymphoma 30.78 10.72 36 115323 2949 50486816
Aspergillus test positive 30.60 10.72 15 115344 316 50489449
Herpes simplex hepatitis 30.52 10.72 15 115344 318 50489447
Localised infection 30.51 10.72 10 115349 25475 50464290
Cytopenia 30.44 10.72 64 115295 8711 50481054
Pancreatitis necrotising 30.40 10.72 25 115334 1328 50488437
Crying 30.39 10.72 5 115354 20411 50469354
Hepatic fibrosis 30.36 10.72 37 115322 3165 50486600
Intervertebral disc protrusion 30.35 10.72 5 115354 20388 50469377
Respiratory syncytial virus infection 30.27 10.72 47 115312 5055 50484710
Endocarditis enterococcal 30.26 10.72 9 115350 42 50489723
Central nervous system lymphoma 30.21 10.72 25 115334 1340 50488425
Upper respiratory tract inflammation 30.12 10.72 32 115327 2357 50487408
Chronic hepatitis C 30.07 10.72 12 115347 151 50489614
Fluid retention 30.01 10.72 43 115316 50606 50439159
Urinary tract infection pseudomonal 29.88 10.72 20 115339 773 50488992
Presyncope 29.85 10.72 9 115350 24189 50465576
Nasal congestion 29.70 10.72 44 115315 51076 50438689
Urinary tract infection 29.70 10.72 694 114665 223326 50266439
Citrobacter infection 29.65 10.72 15 115344 339 50489426
Superinfection bacterial 29.61 10.72 17 115342 498 50489267
Type 1 diabetes mellitus 29.56 10.72 36 115323 3077 50486688
Device issue 29.49 10.72 5 115354 19967 50469798
Cutaneous blastomycosis 29.41 10.72 7 115352 10 50489755
Metastatic squamous cell carcinoma 29.37 10.72 13 115346 215 50489550
Human herpesvirus 6 infection reactivation 29.30 10.72 11 115348 116 50489649
Glomerulonephritis rapidly progressive 29.30 10.72 20 115339 799 50488966
Sebaceous carcinoma 29.17 10.72 8 115351 26 50489739
Neoplasm progression 29.15 10.72 15 115344 29142 50460623
Disseminated varicella zoster vaccine virus infection 29.12 10.72 9 115350 49 50489716
Varicella 29.10 10.72 27 115332 1687 50488078
Agitation 29.06 10.72 48 115311 53336 50436429
Morphoea 29.00 10.72 14 115345 285 50489480
Aplastic anaemia 28.87 10.72 58 115301 7645 50482120
Urosepsis 28.69 10.72 89 115270 15376 50474389
Disseminated blastomycosis 28.64 10.72 7 115352 12 50489753
Gastric ulcer 28.51 10.72 110 115249 21195 50468570
Beta-N-acetyl-D-glucosaminidase increased 28.50 10.72 8 115351 29 50489736
Muscle spasticity 28.47 10.72 3 115356 17181 50472584
Renal artery thrombosis 28.44 10.72 10 115349 86 50489679
Limb discomfort 28.39 10.72 10 115349 24347 50465418
Migraine 28.35 10.72 83 115276 75197 50414568
Large intestinal ulcer 28.35 10.72 35 115324 3034 50486731
Subcutaneous emphysema 28.31 10.72 19 115340 738 50489027
Heart disease congenital 28.28 10.72 23 115336 1203 50488562
Gastrointestinal lymphoma 28.25 10.72 9 115350 55 50489710
Blood albumin increased 28.10 10.72 20 115339 855 50488910
Moyamoya disease 27.97 10.72 9 115350 57 50489708
Foot deformity 27.95 10.72 5 115354 19205 50470560
Chromoblastomycosis 27.94 10.72 7 115352 14 50489751
Limb hypoplasia congenital 27.93 10.72 12 115347 184 50489581
Escherichia pyelonephritis 27.92 10.72 15 115344 385 50489380
Toothache 27.86 10.72 3 115356 16891 50472874
Depressed mood 27.85 10.72 22 115337 34001 50455764
Nosocomial infection 27.84 10.72 25 115334 1497 50488268
Biloma 27.84 10.72 9 115350 58 50489707
Granuloma 27.78 10.72 44 115315 4814 50484951
Renal ischaemia 27.69 10.72 17 115342 565 50489200
Histoplasmosis cutaneous 27.62 10.72 7 115352 15 50489750
Cytomegalovirus nephritis 27.62 10.72 7 115352 15 50489750
Angiosarcoma metastatic 27.62 10.72 7 115352 15 50489750
Cognitive disorder 27.61 10.72 36 115323 44087 50445678
Gallbladder disorder 27.54 10.72 3 115356 16739 50473026
Unevaluable event 27.40 10.72 39 115320 46027 50443738
Central nervous system infection 27.38 10.72 18 115341 675 50489090
Nephrogenic systemic fibrosis 27.32 10.72 41 115318 4281 50485484
Inappropriate schedule of product administration 27.20 10.72 79 115280 71752 50418013
Pneumonia pneumococcal 27.07 10.72 26 115333 1697 50488068
Skin graft rejection 27.02 10.72 7 115352 17 50489748
Gastroenteritis adenovirus 26.97 10.72 11 115348 147 50489618
Congenital diaphragmatic hernia 26.92 10.72 12 115347 202 50489563
Stomatitis 26.90 10.72 129 115230 101215 50388550
Conjunctival melanoma 26.89 10.72 6 115353 5 50489760
Histology abnormal 26.85 10.72 10 115349 103 50489662
Adult T-cell lymphoma/leukaemia 26.76 10.72 12 115347 205 50489560
Azotaemia 26.74 10.72 39 115320 3969 50485796
Cutaneous malacoplakia 26.73 10.72 7 115352 18 50489747
Diaphragmatic hernia 26.68 10.72 14 115345 342 50489423
Hypoglycaemia 26.62 10.72 51 115308 53530 50436235
Full blood count abnormal 26.59 10.72 10 115349 23378 50466387
Brain herniation 26.55 10.72 34 115325 3058 50486707
Intrauterine infection 26.51 10.72 10 115349 107 50489658
Blood beta-D-glucan increased 26.50 10.72 12 115347 210 50489555
Hip fracture 26.43 10.72 13 115346 25918 50463847
Scleroderma renal crisis 26.30 10.72 13 115346 279 50489486
Caesarean section 26.28 10.72 87 115272 15552 50474213
Toxic encephalopathy 26.25 10.72 46 115313 5469 50484296
Adenovirus reactivation 26.18 10.72 10 115349 111 50489654
Blood lactate dehydrogenase increased 26.18 10.72 101 115258 19461 50470304
Endocarditis 26.15 10.72 44 115315 5063 50484702
Premature labour 26.06 10.72 71 115288 11405 50478360
Fusarium infection 26.00 10.72 16 115343 534 50489231
Type 2 diabetes mellitus 25.98 10.72 24 115335 34351 50455414
Skin mass 25.97 10.72 44 115315 5091 50484674
Neuropsychiatric lupus 25.89 10.72 11 115348 164 50489601
Bone marrow transplant 25.87 10.72 17 115342 637 50489128
Microangiopathy 25.67 10.72 19 115340 864 50488901
Renal haematoma 25.65 10.72 11 115348 168 50489597
Acute hepatitis C 25.64 10.72 9 115350 77 50489688
Hair follicle tumour benign 25.58 10.72 14 115345 373 50489392
Gastroenteritis 25.49 10.72 113 115246 23168 50466597
Herpes simplex oesophagitis 25.49 10.72 10 115349 120 50489645
Illness 25.48 10.72 12 115347 24528 50465237
Gestational hypertension 25.46 10.72 28 115331 2145 50487620
Hepatic artery aneurysm 25.45 10.72 6 115353 8 50489757
Klebsiella bacteraemia 25.41 10.72 22 115337 1255 50488510
Acid fast bacilli infection 25.37 10.72 8 115351 47 50489718
Diabetic macroangiopathy 25.34 10.72 10 115349 122 50489643
Cutaneous leishmaniasis 25.33 10.72 9 115350 80 50489685
Surgical procedure repeated 25.32 10.72 12 115347 234 50489531
Injection site mass 25.32 10.72 3 115356 15677 50474088
Meningitis 25.26 10.72 48 115311 6073 50483692
Muir-Torre syndrome 25.24 10.72 7 115352 24 50489741
Rhesus antigen positive 25.19 10.72 10 115349 124 50489641
Stomatococcal infection 25.14 10.72 9 115350 82 50489683
Lupus enteritis 25.09 10.72 8 115351 49 50489716
Atrial fibrillation 25.02 10.72 133 115226 101612 50388153
Endophthalmitis 24.94 10.72 32 115327 2884 50486881
Transient ischaemic attack 24.92 10.72 22 115337 32188 50457577
Amnesia 24.92 10.72 36 115323 42224 50447541
Pericardial effusion 24.91 10.72 120 115239 25469 50464296
Cerebral fungal infection 24.82 10.72 8 115351 51 50489714
Cutaneous nocardiosis 24.81 10.72 7 115352 26 50489739
Bone marrow oedema 24.76 10.72 18 115341 796 50488969
Pyrexia 24.75 10.72 1081 114278 379122 50110643
Congenital oral malformation 24.74 10.72 11 115348 184 50489581
Aspergillosis oral 24.69 10.72 8 115351 52 50489713
Full blood count decreased 24.67 10.72 10 115349 22336 50467429
Systemic bacterial infection 24.65 10.72 6 115353 10 50489755
Lethargy 24.60 10.72 47 115312 49385 50440380
Muscular weakness 24.60 10.72 122 115237 94891 50394874
Erythema infectiosum 24.58 10.72 9 115350 88 50489677
Mediastinitis 24.53 10.72 11 115348 188 50489577
Eosinophilic oesophagitis 24.47 10.72 12 115347 253 50489512
Agranulocytosis 24.23 10.72 105 115254 21316 50468449
Musculoskeletal disorder 24.21 10.72 5 115354 17344 50472421
Hydrocephalus 24.18 10.72 41 115318 4747 50485018
Diverticulitis 24.10 10.72 24 115335 33158 50456607
Avian influenza 24.06 10.72 8 115351 57 50489708
Herpes simplex viraemia 23.97 10.72 10 115349 142 50489623
Cytomegalovirus oesophagitis 23.91 10.72 11 115348 200 50489565
Chronic graft versus host disease in eye 23.88 10.72 9 115350 96 50489669
Intussusception 23.88 10.72 14 115345 427 50489338
Molluscum contagiosum 23.86 10.72 11 115348 201 50489564
Eye infection toxoplasmal 23.85 10.72 12 115347 268 50489497
Infective keratitis 23.83 10.72 7 115352 31 50489734
Renal and pancreas transplant rejection 23.63 10.72 6 115353 13 50489752
Biliary fistula 23.63 10.72 6 115353 13 50489752
Hyperkalaemia 23.60 10.72 189 115170 47900 50441865
Fryns syndrome 23.59 10.72 8 115351 61 50489704
Disseminated mycobacterium avium complex infection 23.48 10.72 7 115352 33 50489732
Drug specific antibody absent 23.48 10.72 8 115351 62 50489703
Sopor 23.45 10.72 8 115351 19871 50469894
Pulmonary hypoplasia 23.45 10.72 12 115347 278 50489487
Blood calcium decreased 23.29 10.72 9 115350 20697 50469068
Dysstasia 23.15 10.72 6 115353 17813 50471952
Blood pressure systolic increased 23.14 10.72 28 115331 35421 50454344
Pallor 23.09 10.72 12 115347 23187 50466578
Pancreatic leak 23.09 10.72 5 115354 3 50489762
Pelvic deformity 23.05 10.72 11 115348 218 50489547
Perihepatic abscess 23.03 10.72 6 115353 15 50489750
Necrotising retinitis 22.95 10.72 12 115347 291 50489474
Renal vein thrombosis 22.95 10.72 12 115347 291 50489474
Tendonitis 22.93 10.72 5 115354 16700 50473065
Multiple sclerosis 22.90 10.72 9 115350 20484 50469281
Injection site haemorrhage 22.84 10.72 10 115349 21336 50468429
Cat scratch disease 22.78 10.72 10 115349 162 50489603
Bursitis 22.71 10.72 11 115348 22124 50467641
Milk allergy 22.56 10.72 10 115349 166 50489599
Orbital apex syndrome 22.51 10.72 7 115352 39 50489726
Peripheral T-cell lymphoma unspecified 22.51 10.72 10 115349 167 50489598
Demodicidosis 22.50 10.72 5 115354 4 50489761
Lymphadenopathy 22.47 10.72 142 115217 33357 50456408
Aggression 22.43 10.72 10 115349 21106 50468659
Lymphoma 22.40 10.72 60 115299 9541 50480224
Cardiac tamponade 22.39 10.72 37 115322 4195 50485570
Hepatic infarction 22.38 10.72 15 115344 581 50489184
Splenic vein thrombosis 22.30 10.72 12 115347 309 50489456
Acid base balance abnormal 22.26 10.72 11 115348 236 50489529
Fat necrosis 22.18 10.72 15 115344 590 50489175
Atypical mycobacterial infection 22.15 10.72 17 115342 817 50488948
Arterial rupture 22.02 10.72 12 115347 317 50489448
Procedural failure 21.98 10.72 5 115354 5 50489760
Urinary tract candidiasis 21.95 10.72 14 115345 498 50489267
Nephrocalcinosis 21.89 10.72 18 115341 956 50488809
Device malfunction 21.86 10.72 4 115355 15117 50474648
Meningomyelitis herpes 21.76 10.72 6 115353 20 50489745
Granulomatous rosacea 21.76 10.72 6 115353 20 50489745
Autoimmune hepatitis 21.76 10.72 51 115308 7468 50482297
Retrognathia 21.75 10.72 13 115346 411 50489354
Plasmablastic lymphoma 21.73 10.72 10 115349 182 50489583
Legionella infection 21.64 10.72 13 115346 415 50489350
Cerebral haemorrhage 21.57 10.72 120 115239 26932 50462833
Squamous cell carcinoma of the vulva 21.54 10.72 6 115353 21 50489744
Bone marrow granuloma 21.54 10.72 6 115353 21 50489744
Enterobacter pneumonia 21.54 10.72 6 115353 21 50489744
Biliary tract infection fungal 21.50 10.72 5 115354 6 50489759
Skin squamous cell carcinoma recurrent 21.50 10.72 5 115354 6 50489759
Endothelial dysfunction 21.50 10.72 9 115350 129 50489636
Parvovirus infection 21.48 10.72 10 115349 187 50489578
Tracheo-oesophageal fistula 21.41 10.72 14 115345 520 50489245
Cholangitis infective 21.38 10.72 10 115349 189 50489576
Dry eye 21.33 10.72 25 115334 32070 50457695
Urinary tract infection enterococcal 21.27 10.72 27 115332 2407 50487358
Transaminases increased 21.25 10.72 122 115237 27702 50462063
Pneumonia staphylococcal 21.16 10.72 28 115331 2601 50487164
Breast cancer 21.15 10.72 41 115318 42849 50446916
Acute myeloid leukaemia 21.14 10.72 79 115280 14995 50474770
Moraxella infection 21.14 10.72 12 115347 344 50489421
Impaired work ability 21.08 10.72 3 115356 13637 50476128
Immunosuppressant drug level 21.07 10.72 5 115354 7 50489758
Removal of renal transplant 21.07 10.72 5 115354 7 50489758
Alpha haemolytic streptococcal infection 21.05 10.72 17 115342 880 50488885
Femur fracture 21.04 10.72 33 115326 37431 50452334
Cleft lip and palate 20.92 10.72 12 115347 351 50489414
Focal myositis 20.91 10.72 6 115353 24 50489741
Pleocytosis 20.81 10.72 14 115345 546 50489219
Tracheobronchitis 20.80 10.72 18 115341 1026 50488739
Sinus disorder 20.80 10.72 8 115351 18450 50471315
Intervertebral disc degeneration 20.71 10.72 3 115356 13458 50476307
Fear 20.71 10.72 4 115355 14545 50475220
Eye swelling 20.68 10.72 10 115349 20134 50469631
Necrosis 20.62 10.72 38 115321 4698 50485067
Enterocolitis viral 20.56 10.72 10 115349 207 50489558
Skin hypertrophy 20.48 10.72 30 115329 3065 50486700
Mycoplasma test positive 20.46 10.72 7 115352 55 50489710
Neurofibrosarcoma 20.44 10.72 9 115350 147 50489618
Body temperature decreased 20.40 10.72 6 115353 16389 50473376
Drug level 20.34 10.72 4 115355 0 50489765
Biliary ischaemia 20.34 10.72 4 115355 0 50489765
Septic embolus 20.31 10.72 16 115343 799 50488966
Pleomorphism 20.30 10.72 5 115354 9 50489756
Fungal abscess central nervous system 20.30 10.72 5 115354 9 50489756
Gallbladder rupture 20.12 10.72 12 115347 378 50489387
Abdominal wound dehiscence 20.11 10.72 9 115350 153 50489612
Vascular pseudoaneurysm 20.09 10.72 20 115339 1364 50488401
Portal vein thrombosis 20.07 10.72 25 115334 2187 50487578
Gingival hypertrophy 20.07 10.72 20 115339 1366 50488399
Photodermatosis 19.89 10.72 12 115347 386 50489379
Limbic encephalitis 19.89 10.72 10 115349 223 50489542
Cholelithiasis 19.88 10.72 35 115324 37938 50451827
Renal atrophy 19.84 10.72 19 115340 1236 50488529
Graft versus host disease in eye 19.83 10.72 7 115352 61 50489704
Portal hypertension 19.78 10.72 31 115328 3361 50486404
Red blood cell count decreased 19.77 10.72 29 115330 33806 50455959
Lacrimation increased 19.76 10.72 7 115352 16985 50472780
Bacterial translocation 19.75 10.72 9 115350 160 50489605
Talipes 19.73 10.72 20 115339 1394 50488371
Leukaemic infiltration extramedullary 19.73 10.72 7 115352 62 50489703
Tinnitus 19.69 10.72 21 115338 28111 50461654
Serositis 19.68 10.72 14 115345 598 50489167
Encephalomyelitis 19.68 10.72 8 115351 106 50489659
Malignant ascites 19.67 10.72 16 115343 837 50488928
Pneumoperitoneum 19.66 10.72 19 115340 1250 50488515
Gastric disorder 19.65 10.72 23 115336 29525 50460240
Pseudallescheria infection 19.64 10.72 5 115354 11 50489754
Hepatic vein occlusion 19.63 10.72 7 115352 63 50489702
Road traffic accident 19.62 10.72 16 115343 24336 50465429
Myopathy toxic 19.59 10.72 12 115347 397 50489368
Carpal tunnel syndrome 19.58 10.72 7 115352 16886 50472879
Protein urine present 19.57 10.72 40 115319 5337 50484428
Gait inability 19.50 10.72 34 115325 36993 50452772
Hepatitis cholestatic 19.37 10.72 43 115316 6074 50483691
Blood pressure diastolic decreased 19.37 10.72 7 115352 16774 50472991
Injection site warmth 19.34 10.72 4 115355 13862 50475903
Periportal oedema 19.34 10.72 5 115354 12 50489753
Growth failure 19.26 10.72 11 115348 319 50489446
Panic attack 19.26 10.72 10 115349 19332 50470433
Abdominal distension 19.22 10.72 93 115266 72810 50416955
Liver disorder 19.20 10.72 148 115211 37074 50452691
Pneumonia haemophilus 19.18 10.72 13 115346 513 50489252
Increased insulin requirement 19.16 10.72 7 115352 68 50489697
Delusional disorder, persecutory type 19.11 10.72 9 115350 173 50489592
Haemothorax 19.10 10.72 23 115336 1943 50487822
Clostridium difficile infection 19.07 10.72 111 115248 25328 50464437
Ischaemic nephropathy 19.06 10.72 5 115354 13 50489752
Mucinous adenocarcinoma of appendix 19.06 10.72 5 115354 13 50489752
Pterygium colli 19.06 10.72 5 115354 13 50489752
Hiatus hernia 19.00 10.72 9 115350 18335 50471430
Coombs positive haemolytic anaemia 18.99 10.72 11 115348 328 50489437
Infectious pleural effusion 18.99 10.72 18 115341 1156 50488609
Viral diarrhoea 18.96 10.72 8 115351 117 50489648
Respiratory tract infection viral 18.96 10.72 22 115337 1787 50487978
Idiopathic pneumonia syndrome 18.96 10.72 11 115348 329 50489436
Pneumonia respiratory syncytial viral 18.92 10.72 14 115345 636 50489129
Purulent pericarditis 18.92 10.72 6 115353 36 50489729
Chromaturia 18.79 10.72 5 115354 14585 50475180
Coinfection 18.79 10.72 5 115354 14 50489751
Chylothorax 18.78 10.72 10 115349 252 50489513
Asterixis 18.76 10.72 18 115341 1173 50488592
Cardiac disorder 18.76 10.72 44 115315 42935 50446830
Anastomotic complication 18.72 10.72 8 115351 121 50489644
Stem cell transplant 18.69 10.72 21 115338 1647 50488118
Fungaemia 18.67 10.72 23 115336 1989 50487776
Pneumonia herpes viral 18.65 10.72 6 115353 38 50489727
Lung infiltration 18.62 10.72 70 115289 13323 50476442
Mycobacterium chelonae infection 18.61 10.72 12 115347 435 50489330
Aeromonas infection 18.55 10.72 7 115352 75 50489690
Hyperoxaluria 18.54 10.72 8 115351 124 50489641
Restlessness 18.52 10.72 18 115341 25155 50464610
Biliary obstruction 18.52 10.72 25 115334 2368 50487397
Pericarditis constrictive 18.49 10.72 11 115348 345 50489420
Urine output decreased 18.43 10.72 59 115300 10362 50479403
Diarrhoea infectious 18.43 10.72 16 115343 916 50488849
Plasmapheresis 18.43 10.72 10 115349 262 50489503
Hypersomnia 18.35 10.72 6 115353 15308 50474457
Epileptic encephalopathy 18.29 10.72 10 115349 266 50489499
Transient acantholytic dermatosis 18.26 10.72 6 115353 41 50489724
Pulmonary tuberculosis 18.25 10.72 34 115325 4239 50485526
Bone disorder 18.22 10.72 10 115349 18742 50471023
Dyspnoea exertional 18.21 10.72 58 115301 51175 50438590
Pupil fixed 18.18 10.72 20 115339 1532 50488233
Body temperature increased 18.18 10.72 27 115332 31314 50458451
Feeling cold 18.15 10.72 11 115348 19520 50470245
Clostridium test positive 18.13 10.72 23 115336 2049 50487716
Unresponsive to stimuli 18.12 10.72 26 115333 30583 50459182
Calciphylaxis 18.08 10.72 26 115333 2612 50487153
Metapneumovirus infection 18.08 10.72 15 115344 807 50488958
Underdose 18.05 10.72 12 115347 20266 50469499
Arteritis infective 18.01 10.72 6 115353 43 50489722
Haematemesis 17.99 10.72 22 115337 27703 50462062
Disturbance in attention 17.96 10.72 27 115332 31159 50458606
Cutaneous T-cell lymphoma 17.86 10.72 18 115341 1246 50488519
Arteriovenous fistula occlusion 17.85 10.72 11 115348 368 50489397
Anaphylactic shock 17.84 10.72 12 115347 20143 50469622
Angina pectoris 17.83 10.72 20 115339 26168 50463597
Chills 17.82 10.72 138 115221 96549 50393216
Chronic hepatitis 17.79 10.72 15 115344 825 50488940
Campylobacter infection 17.77 10.72 14 115345 699 50489066
Apoptosis 17.77 10.72 7 115352 85 50489680
Restless legs syndrome 17.73 10.72 7 115352 15890 50473875
Obesity 17.73 10.72 8 115351 16767 50472998
Continuous haemodiafiltration 17.71 10.72 16 115343 966 50488799
Joint effusion 17.67 10.72 4 115355 13017 50476748
Desmoplastic melanoma 17.58 10.72 4 115355 4 50489761
Transplant abscess 17.58 10.72 4 115355 4 50489761
Fascioliasis 17.58 10.72 4 115355 4 50489761
Acute allograft nephropathy 17.58 10.72 4 115355 4 50489761
Extranodal marginal zone B-cell lymphoma (MALT type) stage IV 17.58 10.72 4 115355 4 50489761
Ear infection 17.50 10.72 20 115339 25950 50463815
Mesothelioma malignant 17.44 10.72 6 115353 48 50489717
Paraneoplastic pemphigus 17.44 10.72 6 115353 48 50489717
Sporotrichosis 17.43 10.72 5 115354 20 50489745
Squamous cell carcinoma of the oral cavity 17.36 10.72 10 115349 295 50489470
Gastrointestinal disorder 17.32 10.72 135 115224 94321 50395444
Disseminated tuberculosis 17.31 10.72 25 115334 2521 50487244
Therapy partial responder 17.24 10.72 43 115316 6548 50483217
Nephrogenic diabetes insipidus 17.17 10.72 15 115344 866 50488899
Blue toe syndrome 17.15 10.72 11 115348 395 50489370
Asteatosis 17.13 10.72 6 115353 51 50489714
Superinfection viral 17.05 10.72 5 115354 22 50489743
Thyroid disorder 16.99 10.72 4 115355 12673 50477092
Polyhydramnios 16.97 10.72 22 115337 2003 50487762
Blood iron decreased 16.95 10.72 3 115356 11612 50478153
Gastritis fungal 16.93 10.72 7 115352 97 50489668
Renal cortical necrosis 16.87 10.72 7 115352 98 50489667
Choriomeningitis lymphocytic 16.87 10.72 5 115354 23 50489742
Vascular graft complication 16.87 10.72 5 115354 23 50489742
Oliguria 16.86 10.72 49 115310 8167 50481598
Graft infection 16.83 10.72 8 115351 157 50489608
Cachexia 16.83 10.72 34 115325 4499 50485266
Blood culture positive 16.82 10.72 33 115326 4275 50485490
Corynebacterium infection 16.77 10.72 11 115348 411 50489354
Pneumonia cryptococcal 16.73 10.72 13 115346 636 50489129
Reperfusion injury 16.73 10.72 6 115353 55 50489710
Hepatitis viral 16.72 10.72 11 115348 413 50489352
Drug trough level 16.70 10.72 5 115354 24 50489741
Night sweats 16.64 10.72 32 115327 33542 50456223
Oral lichen planus 16.60 10.72 12 115347 526 50489239
Acute motor axonal neuropathy 16.53 10.72 5 115354 25 50489740
Osteoporosis 16.52 10.72 50 115309 44829 50444936
Cardio-respiratory arrest 16.49 10.72 65 115294 53827 50435938
Adrenal mass 16.48 10.72 14 115345 778 50488987
Tongue ulceration 16.39 10.72 27 115332 3053 50486712
Mucosal necrosis 16.37 10.72 5 115354 26 50489739
Pancreatic pseudocyst haemorrhage 16.31 10.72 4 115355 7 50489758
Acute myeloid leukaemia (in remission) 16.31 10.72 4 115355 7 50489758
Septal panniculitis 16.27 10.72 6 115353 60 50489705
Electrocardiogram QT prolonged 16.25 10.72 62 115297 51824 50437941
Glycosuria 16.24 10.72 16 115343 1078 50488687
Reversible cerebral vasoconstriction syndrome 16.19 10.72 22 115337 2097 50487668
Leukaemia recurrent 16.17 10.72 17 115342 1237 50488528
Skin induration 16.14 10.72 26 115333 2885 50486880
Upper limb fracture 16.11 10.72 8 115351 15865 50473900
Paraesthesia oral 16.10 10.72 4 115355 12217 50477548
Toxic optic neuropathy 16.09 10.72 8 115351 174 50489591
Osteonecrosis 16.07 10.72 97 115262 22420 50467345
Eye pain 16.03 10.72 25 115334 28424 50461341
Renal cyst infection 16.03 10.72 7 115352 112 50489653
Neuroleptic malignant syndrome 15.97 10.72 3 115356 11127 50478638
Parapox virus infection 15.97 10.72 4 115355 8 50489757
Immunosuppression 15.93 10.72 45 115314 7381 50482384
Panophthalmitis 15.92 10.72 6 115353 64 50489701
Arterial thrombosis 15.91 10.72 17 115342 1260 50488505
Blood glucose decreased 15.91 10.72 11 115348 18200 50471565
Grip strength decreased 15.90 10.72 4 115355 12117 50477648
Craniofacial deformity 15.86 10.72 7 115352 115 50489650
Urinary retention 15.75 10.72 22 115337 26168 50463597
Fanconi syndrome 15.73 10.72 16 115343 1120 50488645
Urinary incontinence 15.69 10.72 25 115334 28183 50461582
Bacterial colitis 15.68 10.72 6 115353 67 50489698
Colorectal adenocarcinoma 15.68 10.72 6 115353 67 50489698
Head injury 15.65 10.72 19 115340 24001 50465764
Pancreatic abscess 15.65 10.72 4 115355 9 50489756
Wound infection fungal 15.59 10.72 7 115352 120 50489645
Biliary tract disorder 15.58 10.72 13 115346 705 50489060
Dysphagia 15.55 10.72 108 115251 77410 50412355
Ophthalmic herpes simplex 15.52 10.72 10 115349 362 50489403
Seasonal allergy 15.51 10.72 7 115352 14669 50475096
Gastrointestinal necrosis 15.51 10.72 24 115335 2574 50487191
Throat cancer 15.50 10.72 11 115348 468 50489297
Scleroderma 15.49 10.72 34 115325 4767 50484998
Hyperparathyroidism 15.40 10.72 23 115336 2391 50487374
Emotional distress 15.39 10.72 26 115333 28637 50461128
Cerebral ventricle collapse 15.37 10.72 5 115354 33 50489732
Erythropoiesis abnormal 15.37 10.72 9 115350 274 50489491
Complications of intestinal transplant 15.36 10.72 4 115355 10 50489755
Chimerism 15.36 10.72 4 115355 10 50489755
Vasogenic cerebral oedema 15.34 10.72 11 115348 476 50489289
Muscle twitching 15.33 10.72 8 115351 15423 50474342
Cytotoxic oedema 15.33 10.72 7 115352 125 50489640
Autoinflammatory disease 15.29 10.72 6 115353 72 50489693
Visual impairment 15.29 10.72 92 115267 68183 50421582
Multiple organ transplant rejection 15.26 10.72 3 115356 0 50489765
Sarcoma metastatic 15.26 10.72 3 115356 0 50489765
Mesenteric fibrosis 15.26 10.72 3 115356 0 50489765
Corynebacterium bacteraemia 15.26 10.72 3 115356 0 50489765
Oropharyngeal lymphoid hyperplasia 15.26 10.72 3 115356 0 50489765
Vascular hyalinosis 15.26 10.72 3 115356 0 50489765
Complications of transplanted pancreas 15.26 10.72 3 115356 0 50489765
Portal vein flow decreased 15.26 10.72 3 115356 0 50489765
Heart rate irregular 15.25 10.72 13 115346 19347 50470418
Achromobacter infection 15.24 10.72 5 115354 34 50489731
Throat tightness 15.23 10.72 15 115344 20832 50468933
Dermatitis allergic 15.21 10.72 5 115354 12715 50477050
Jejunal ulcer perforation 15.11 10.72 5 115354 35 50489730
Burning sensation 15.09 10.72 53 115306 45393 50444372
Spinal stenosis 15.06 10.72 6 115353 13544 50476221
Medication error 14.94 10.72 38 115321 36066 50453699
Hepatitis B reactivation 14.94 10.72 21 115338 2066 50487699
Acute pulmonary histoplasmosis 14.89 10.72 7 115352 134 50489631
Pneumonia 14.87 10.72 1027 114332 377374 50112391
Tonsil cancer 14.87 10.72 8 115351 206 50489559
Chronic myeloid leukaemia recurrent 14.87 10.72 8 115351 206 50489559
Pancreatic pseudoaneurysm 14.86 10.72 6 115353 78 50489687
Venous haemorrhage 14.83 10.72 8 115351 207 50489558
Osteomyelitis fungal 14.83 10.72 4 115355 12 50489753
Hepatic echinococciasis 14.83 10.72 4 115355 12 50489753
Dermatitis papillaris capillitii 14.83 10.72 4 115355 12 50489753
Respiratory tract infection fungal 14.82 10.72 10 115349 392 50489373
Normal newborn 14.80 10.72 41 115318 6650 50483115
Haemorrhagic ovarian cyst 14.80 10.72 12 115347 625 50489140
Norovirus test positive 14.79 10.72 7 115352 136 50489629
Surgery 14.79 10.72 29 115330 30176 50459589
Product quality issue 14.79 10.72 30 115329 30828 50458937
Flatulence 14.67 10.72 28 115331 29430 50460335
Product complaint 14.63 10.72 4 115355 11462 50478303
Transplant 14.58 10.72 12 115347 638 50489127
Dyslipidaemia 14.56 10.72 38 115321 5950 50483815
Pneumopericardium 14.54 10.72 5 115354 40 50489725
Abnormal behaviour 14.53 10.72 14 115345 19644 50470121
Tooth infection 14.50 10.72 7 115352 14105 50475660
Meningitis viral 14.49 10.72 16 115343 1231 50488534
Pneumothorax spontaneous 14.49 10.72 12 115347 644 50489121
Aortic rupture 14.46 10.72 6 115353 84 50489681
Pulmonary embolism 14.46 10.72 155 115204 101549 50388216
Anal ulcer 14.45 10.72 11 115348 522 50489243
Skin laceration 14.42 10.72 13 115346 18829 50470936
Anger 14.38 10.72 4 115355 11329 50478436
Glomerulonephritis membranous 14.27 10.72 11 115348 532 50489233
White blood cell count decreased 14.24 10.72 184 115175 116538 50373227
Abdominal compartment syndrome 14.21 10.72 11 115348 535 50489230
Cholangitis acute 14.19 10.72 10 115349 421 50489344
Lung adenocarcinoma 14.16 10.72 30 115329 4104 50485661
Oesophageal squamous cell carcinoma stage IV 14.15 10.72 4 115355 15 50489750
Mycobacterium haemophilum infection 14.15 10.72 4 115355 15 50489750
Dacryocystitis 14.15 10.72 4 115355 15 50489750
Pelvic pain 14.14 10.72 4 115355 11209 50478556
Blood stem cell transplant failure 14.13 10.72 7 115352 151 50489614
Immune thrombocytopenia 14.13 10.72 49 115310 8968 50480797
Optic atrophy 14.09 10.72 15 115344 1107 50488658
Oropharyngeal candidiasis 14.07 10.72 14 115345 954 50488811
Cerebral mass effect 14.06 10.72 13 115346 809 50488956
Small cell lung cancer recurrent 13.94 10.72 4 115355 16 50489749
Microgenia 13.94 10.72 4 115355 16 50489749
Skin squamous cell carcinoma metastatic 13.94 10.72 4 115355 16 50489749
Tonsillar exudate 13.94 10.72 4 115355 16 50489749
Malignant anorectal neoplasm 13.94 10.72 4 115355 16 50489749
Ileal ulcer 13.94 10.72 10 115349 433 50489332
Amyloidosis 13.89 10.72 14 115345 969 50488796
Rib fracture 13.85 10.72 14 115345 19207 50470558
Sciatica 13.84 10.72 17 115342 21365 50468400
Parotitis 13.83 10.72 16 115343 1295 50488470
Beta 2 microglobulin urine increased 13.83 10.72 5 115354 47 50489718
Head discomfort 13.77 10.72 4 115355 11015 50478750
Acute vestibular syndrome 13.75 10.72 4 115355 17 50489748
Lymphocytopenia neonatal 13.75 10.72 4 115355 17 50489748
Viral skin infection 13.75 10.72 4 115355 17 50489748
Coarctation of the aorta 13.75 10.72 11 115348 562 50489203
Myopathy 13.75 10.72 49 115310 9090 50480675
Jejunal ulcer 13.74 10.72 6 115353 96 50489669
Neutrophilic panniculitis 13.74 10.72 5 115354 48 50489717
Dystonia 13.72 10.72 5 115354 11921 50477844
Lip swelling 13.69 10.72 22 115337 24714 50465051
Hirsutism 13.66 10.72 14 115345 989 50488776
Viral load increased 13.65 10.72 15 115344 1148 50488617
Ecthyma 13.65 10.72 8 115351 244 50489521
Autoimmune pancytopenia 13.62 10.72 6 115353 98 50489667
Extranodal marginal zone B-cell lymphoma (MALT type) 13.62 10.72 10 115349 449 50489316
Endocarditis staphylococcal 13.61 10.72 9 115350 341 50489424
Drug level changed 13.61 10.72 7 115352 164 50489601
Immunoglobulins decreased 13.58 10.72 14 115345 996 50488769
Renal glycosuria 13.57 10.72 4 115355 18 50489747
Urinary tract infection fungal 13.56 10.72 11 115348 573 50489192
Metastatic malignant melanoma 13.53 10.72 15 115344 1159 50488606
Therapeutic response unexpected 13.40 10.72 10 115349 15905 50473860
Renal salt-wasting syndrome 13.39 10.72 8 115351 253 50489512
Sarcopenia 13.38 10.72 5 115354 52 50489713
Renal infarct 13.36 10.72 16 115343 1344 50488421
Pulmonary arterial hypertension 13.32 10.72 16 115343 20303 50469462
Rhabdomyolysis 13.30 10.72 45 115314 38982 50450783
Pulmonary fibrosis 13.27 10.72 22 115337 24415 50465350
Herpes zoster 13.26 10.72 231 115128 70555 50419210
Hepatic amoebiasis 13.22 10.72 4 115355 20 50489745
Herpes simplex meningoencephalitis 13.22 10.72 4 115355 20 50489745
Vascular graft thrombosis 13.22 10.72 4 115355 20 50489745
Fluorosis 13.22 10.72 4 115355 20 50489745
Cardiac valve vegetation 13.19 10.72 8 115351 260 50489505
Renal cell carcinoma stage III 13.19 10.72 3 115356 3 50489762
Antithrombin III deficiency 13.19 10.72 3 115356 3 50489762
Flavobacterium infection 13.19 10.72 3 115356 3 50489762
Atrial septal defect 13.19 10.72 38 115321 6303 50483462
Conjunctival neoplasm 13.19 10.72 3 115356 3 50489762
Hepatic artery occlusion 13.19 10.72 3 115356 3 50489762
Phaeohyphomycotic brain abscess 13.19 10.72 3 115356 3 50489762
Pericarditis fungal 13.19 10.72 3 115356 3 50489762
Granulicatella bacteraemia 13.19 10.72 3 115356 3 50489762
Erdheim-Chester disease 13.19 10.72 3 115356 3 50489762
Maternal drugs affecting foetus 13.15 10.72 33 115326 5044 50484721
Hypertensive emergency 13.13 10.72 17 115342 1546 50488219
Vaccination failure 13.11 10.72 9 115350 363 50489402
Nodular regenerative hyperplasia 13.08 10.72 8 115351 264 50489501
Salmonellosis 13.08 10.72 13 115346 885 50488880
Neuroblastoma recurrent 13.06 10.72 4 115355 21 50489744
Cystitis viral 13.05 10.72 6 115353 109 50489656
Bronchoalveolar lavage abnormal 13.05 10.72 6 115353 109 50489656
Intestinal pseudo-obstruction 13.04 10.72 12 115347 742 50489023
Spinal osteoarthritis 13.01 10.72 8 115351 14084 50475681
Coordination abnormal 13.00 10.72 5 115354 11529 50478236
Acute respiratory failure 12.98 10.72 111 115248 28671 50461094
Dermatomyositis 12.95 10.72 20 115339 2141 50487624
B-lymphocyte count decreased 12.93 10.72 13 115346 897 50488868
Thyroid tuberculosis 12.91 10.72 4 115355 22 50489743
Acanthosis 12.90 10.72 6 115353 112 50489653
Joint tuberculosis 12.85 10.72 6 115353 113 50489652
Lymphoid tissue hyperplasia 12.84 10.72 7 115352 185 50489580
Cryptococcal cutaneous infection 12.82 10.72 5 115354 59 50489706
Growth retardation 12.82 10.72 14 115345 1064 50488701
Hepatobiliary infection 12.76 10.72 4 115355 23 50489742
Inflammatory pseudotumour 12.76 10.72 4 115355 23 50489742
Agnosia 12.75 10.72 6 115353 115 50489650
Gastrointestinal toxicity 12.75 10.72 31 115328 4646 50485119
Febrile neutropenia 12.74 10.72 302 115057 97365 50392400
Herpes sepsis 12.73 10.72 3 115356 4 50489761
Portal vein stenosis 12.73 10.72 3 115356 4 50489761
Complement fixation abnormal 12.73 10.72 3 115356 4 50489761
Nephrosclerosis 12.72 10.72 13 115346 915 50488850
Musculoskeletal chest pain 12.72 10.72 14 115345 18472 50471293
Genital herpes simplex 12.71 10.72 7 115352 189 50489576
Eczema 12.69 10.72 92 115267 22610 50467155
Catatonia 12.67 10.72 27 115332 3709 50486056
Acute motor-sensory axonal neuropathy 12.66 10.72 8 115351 280 50489485
Colitis 12.65 10.72 139 115220 38390 50451375
Blast crisis in myelogenous leukaemia 12.65 10.72 10 115349 502 50489263
Drug effective for unapproved indication 12.61 10.72 19 115340 1990 50487775
Biopsy kidney 12.61 10.72 6 115353 118 50489647
Maternal exposure during pregnancy 12.61 10.72 464 114895 159314 50330451
Eating disorder 12.57 10.72 10 115349 15399 50474366
Hypophosphataemia 12.56 10.72 45 115314 8369 50481396
Prescribed overdose 12.51 10.72 9 115350 14591 50475174
Abnormal dreams 12.49 10.72 3 115356 9374 50480391
Pelvic infection 12.48 10.72 8 115351 287 50489478
Jarisch-Herxheimer reaction 12.48 10.72 8 115351 287 50489478
Exposure via partner 12.48 10.72 6 115353 121 50489644
Calcification of muscle 12.48 10.72 4 115355 25 50489740
Bacteroides bacteraemia 12.48 10.72 4 115355 25 50489740
Pollakiuria 12.47 10.72 22 115337 23829 50465936
Mycobacterium kansasii infection 12.43 10.72 6 115353 122 50489643
Nightmare 12.43 10.72 11 115348 16075 50473690
Leiomyoma 12.36 10.72 9 115350 399 50489366
Blood creatine phosphokinase increased 12.32 10.72 26 115333 26341 50463424
Product substitution issue 12.32 10.72 64 115295 13993 50475772
Renal cell carcinoma 12.32 10.72 24 115335 3093 50486672
Polymerase chain reaction positive 12.32 10.72 5 115354 66 50489699
Renal haemorrhage 12.29 10.72 12 115347 799 50488966
Tooth abscess 12.29 10.72 7 115352 12853 50476912
Respiratory tract infection bacterial 12.26 10.72 7 115352 203 50489562
Acidosis 12.24 10.72 51 115308 10176 50479589
Hypertelorism 12.18 10.72 9 115350 408 50489357
Dependence on respirator 12.11 10.72 5 115354 69 50489696
Epstein-Barr virus antibody positive 12.10 10.72 8 115351 303 50489462
Bronchiectasis 12.09 10.72 51 115308 10232 50479533
Fibrin degradation products increased 12.09 10.72 6 115353 130 50489635
Drug tolerance decreased 12.06 10.72 3 115356 9157 50480608
Papule 12.06 10.72 29 115330 4316 50485449
Infection 12.06 10.72 301 115058 172653 50317112
Eye disorder 12.02 10.72 15 115344 18724 50471041
Nephrectomy 12.00 10.72 12 115347 823 50488942
Meningitis aspergillus 11.98 10.72 3 115356 6 50489759
Anion gap normal 11.98 10.72 3 115356 6 50489759
Lymphadenitis viral 11.98 10.72 3 115356 6 50489759
Encephalitis Japanese B 11.97 10.72 4 115355 29 50489736
Hepatic haematoma 11.94 10.72 9 115350 421 50489344
Pancreatitis acute 11.91 10.72 94 115265 23718 50466047
Hypertrophic cardiomyopathy 11.88 10.72 15 115344 1330 50488435
Hypervolaemia 11.85 10.72 99 115260 25400 50464365
Extrapyramidal disorder 11.85 10.72 6 115353 11764 50478001
Hypoacusis 11.77 10.72 18 115341 20629 50469136
Apraxia 11.74 10.72 16 115343 1529 50488236
Musculoskeletal discomfort 11.74 10.72 10 115349 14888 50474877
Blood urea increased 11.73 10.72 93 115266 23492 50466273
Paroxysmal nocturnal haemoglobinuria 11.72 10.72 6 115353 139 50489626
Haematuria 11.67 10.72 99 115260 25514 50464251
Laboratory test abnormal 11.61 10.72 22 115337 23186 50466579
Glomerular filtration rate decreased 11.60 10.72 55 115304 11597 50478168
Intestinal perforation 11.57 10.72 51 115308 10428 50479337
Herpes zoster reactivation 11.52 10.72 4 115355 33 50489732
Stenotrophomonas sepsis 11.52 10.72 4 115355 33 50489732
Refractoriness to platelet transfusion 11.52 10.72 4 115355 33 50489732
Mental status changes 11.52 10.72 130 115229 36142 50453623
Bronchiolitis 11.51 10.72 20 115339 2361 50487404
Abortion induced 11.50 10.72 47 115312 9297 50480468
Hypertensive encephalopathy 11.50 10.72 10 115349 574 50489191
Sinus congestion 11.48 10.72 9 115350 13962 50475803
Hallucination 11.46 10.72 61 115298 46596 50443169
Arteriovenous fistula 11.45 10.72 7 115352 231 50489534
Hepatic steatosis 11.43 10.72 24 115335 24360 50465405
Arrhythmia 11.43 10.72 38 115321 33094 50456671
Hepatic vein stenosis 11.42 10.72 4 115355 34 50489731
Cholangiocarcinoma 11.41 10.72 13 115346 1035 50488730
Skin tightness 11.41 10.72 26 115333 3737 50486028
International normalised ratio increased 11.40 10.72 55 115304 43097 50446668
Intracranial pressure increased 11.40 10.72 28 115331 4224 50485541
Frequent bowel movements 11.39 10.72 9 115350 13909 50475856
Joint dislocation 11.38 10.72 7 115352 12326 50477439
Renal amyloidosis 11.38 10.72 6 115353 148 50489617
Hepatitis C virus test 11.38 10.72 3 115356 8 50489757
Tuberculosis gastrointestinal 11.37 10.72 8 115351 336 50489429
Vulval ulceration 11.36 10.72 7 115352 234 50489531
Anal incontinence 11.35 10.72 6 115353 11484 50478281
Skin plaque 11.35 10.72 36 115323 6292 50483473
Intentional product use issue 11.33 10.72 242 115117 76676 50413089
Glomerulonephropathy 11.28 10.72 5 115354 83 50489682
Dehydration 11.26 10.72 263 115096 152186 50337579
Tonic clonic movements 11.25 10.72 14 115345 1223 50488542
Foetal growth restriction 11.25 10.72 37 115322 6590 50483175
Retroperitoneal haematoma 11.25 10.72 21 115338 2622 50487143
Aspergilloma 11.24 10.72 6 115353 152 50489613
Device related bacteraemia 11.23 10.72 5 115354 84 50489681
Mucocutaneous leishmaniasis 11.22 10.72 8 115351 343 50489422
Gestational diabetes 11.21 10.72 40 115319 7425 50482340
Amyotrophy 11.20 10.72 6 115353 153 50489612
Vitamin D deficiency 11.20 10.72 6 115353 11396 50478369
Carotid artery aneurysm 11.18 10.72 7 115352 241 50489524
Intervertebral discitis 11.17 10.72 21 115338 2635 50487130
Blood pressure decreased 11.16 10.72 78 115281 55831 50433934
Patent ductus arteriosus 11.15 10.72 26 115333 3794 50485971
Anaemia 11.13 10.72 692 114667 251764 50238001
Psoriasis 11.13 10.72 102 115257 68898 50420867
Pharyngeal necrosis 11.12 10.72 3 115356 9 50489756
Adenovirus test positive 11.12 10.72 3 115356 9 50489756
Acquired mitochondrial DNA mutation 11.12 10.72 3 115356 9 50489756
Salivary gland mass 11.12 10.72 5 115354 86 50489679
Urinoma 11.12 10.72 4 115355 37 50489728
Retroperitoneal lymphadenopathy 11.09 10.72 9 115350 469 50489296
Hepatitis infectious mononucleosis 11.07 10.72 5 115354 87 50489678
Mood swings 11.07 10.72 12 115347 15942 50473823
Hypoproteinaemia 11.05 10.72 17 115342 1814 50487951
Peritoneal dialysis 11.02 10.72 8 115351 353 50489412
Nephrostomy 11.02 10.72 5 115354 88 50489677
Acinetobacter bacteraemia 11.02 10.72 5 115354 88 50489677
Palmar-plantar erythrodysaesthesia syndrome 11.00 10.72 18 115341 20080 50469685
Cataract 10.98 10.72 63 115296 47237 50442528
Influenza 10.97 10.72 141 115218 89397 50400368
Irritability 10.95 10.72 31 115328 28395 50461370
Enteritis 10.95 10.72 38 115321 6957 50482808
Epstein-Barr virus antigen positive 10.93 10.72 4 115355 39 50489726
Neisseria infection 10.93 10.72 4 115355 39 50489726
Adenocarcinoma 10.92 10.72 20 115339 2461 50487304
Drug level abnormal 10.91 10.72 5 115354 90 50489675
Oral candidiasis 10.91 10.72 71 115288 16844 50472921
Mental impairment 10.89 10.72 7 115352 12037 50477728
Ventricular remodelling 10.88 10.72 3 115356 10 50489755
Nasal septum ulceration 10.88 10.72 3 115356 10 50489755
Leukaemia in remission 10.88 10.72 3 115356 10 50489755
Picornavirus infection 10.88 10.72 3 115356 10 50489755
Biopsy heart abnormal 10.88 10.72 3 115356 10 50489755
Type III immune complex mediated reaction 10.88 10.72 7 115352 253 50489512
Hypogonadism 10.86 10.72 5 115354 91 50489674
Metastases to lymph nodes 10.86 10.72 38 115321 6986 50482779
Acute hepatic failure 10.85 10.72 67 115292 15610 50474155
Neutrophil count decreased 10.85 10.72 61 115298 45965 50443800
Wound sepsis 10.83 10.72 6 115353 164 50489601
Campylobacter gastroenteritis 10.78 10.72 8 115351 365 50489400
Developmental hip dysplasia 10.78 10.72 14 115345 1277 50488488
Ear pain 10.78 10.72 31 115328 28252 50461513
Rhinorrhoea 10.78 10.72 71 115288 51512 50438253
Sleep apnoea syndrome 10.77 10.72 24 115335 23844 50465921
Anomaly of external ear congenital 10.73 10.72 6 115353 167 50489598
Eye infection 10.73 10.72 4 115355 9402 50480363

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Transplant rejection 2521.54 11.10 1121 144806 8091 29420509
Cytomegalovirus infection 1991.88 11.10 1306 144621 21909 29406691
Polyomavirus-associated nephropathy 1451.05 11.10 568 145359 2828 29425772
Post transplant lymphoproliferative disorder 1446.87 11.10 651 145276 4842 29423758
Immunosuppressant drug level increased 1355.36 11.10 596 145331 4169 29424431
Kidney transplant rejection 1304.83 11.10 654 145273 6351 29422249
Thrombotic microangiopathy 1022.38 11.10 598 145329 8083 29420517
Complications of transplanted kidney 1004.44 11.10 457 145470 3497 29425103
Product use in unapproved indication 918.30 11.10 1583 144344 85292 29343308
BK virus infection 892.85 11.10 445 145482 4262 29424338
Nocardiosis 866.78 11.10 389 145538 2871 29425729
Graft versus host disease 852.72 11.10 553 145374 9075 29419525
Acute graft versus host disease 833.89 11.10 456 145471 5368 29423232
Liver transplant rejection 828.55 11.10 326 145601 1648 29426952
Cytomegalovirus viraemia 823.32 11.10 465 145462 5855 29422745
Transplant dysfunction 744.21 11.10 314 145613 1956 29426644
COVID-19 741.19 11.10 901 145026 35113 29393487
Aspergillus infection 653.33 11.10 487 145440 10094 29418506
Drug level increased 608.52 11.10 597 145330 18190 29410410
Epstein-Barr virus infection 590.00 11.10 382 145545 6247 29422353
Chronic graft versus host disease 572.72 11.10 314 145613 3715 29424885
Mucormycosis 528.56 11.10 325 145602 4833 29423767
Adenovirus infection 517.31 11.10 304 145623 4143 29424457
Fatigue 505.29 11.10 493 145434 316328 29112272
Nephropathy toxic 504.42 11.10 421 145506 10335 29418265
Transplant failure 477.50 11.10 248 145679 2608 29425992
Phaeohyphomycosis 473.71 11.10 170 145757 630 29427970
Graft versus host disease in skin 443.78 11.10 250 145677 3129 29425471
Fall 422.66 11.10 173 145754 177005 29251595
Bronchopulmonary aspergillosis 416.03 11.10 401 145526 11943 29416657
Acute graft versus host disease in skin 413.14 11.10 268 145659 4396 29424204
Off label use 412.25 11.10 2712 143215 298088 29130512
Dizziness 410.93 11.10 212 145715 189472 29239128
Posterior reversible encephalopathy syndrome 401.66 11.10 342 145585 8634 29419966
Immunosuppressant drug level decreased 395.71 11.10 165 145762 993 29427607
Kidney fibrosis 392.50 11.10 195 145732 1852 29426748
Hepatitis E 392.31 11.10 183 145744 1491 29427109
Chronic allograft nephropathy 387.48 11.10 161 145766 959 29427641
Drug interaction 371.23 11.10 1936 143991 195449 29233151
Delayed graft function 364.85 11.10 182 145745 1745 29426855
Completed suicide 360.77 11.10 21 145906 90225 29338375
Enterococcal infection 353.65 11.10 307 145620 7961 29420639
Parvovirus B19 infection 344.49 11.10 131 145796 593 29428007
Dyspnoea 342.11 11.10 687 145240 326045 29102555
Focal segmental glomerulosclerosis 340.15 11.10 170 145757 1637 29426963
Renal impairment 330.36 11.10 1016 144911 80317 29348283
Cryptococcosis 316.31 11.10 166 145761 1786 29426814
Renal transplant failure 315.63 11.10 134 145793 849 29427751
Multiple organ dysfunction syndrome 313.87 11.10 848 145079 62268 29366332
Renal tubular atrophy 308.23 11.10 134 145793 907 29427693
Graft versus host disease in gastrointestinal tract 300.38 11.10 192 145735 3066 29425534
Strongyloidiasis 298.05 11.10 169 145758 2143 29426457
Pneumocystis jirovecii pneumonia 285.21 11.10 382 145545 16397 29412203
Klebsiella infection 284.68 11.10 258 145669 7091 29421509
Pain 277.98 11.10 262 145665 171170 29257430
Pseudomonas infection 277.65 11.10 304 145623 10548 29418052
Asthenia 271.03 11.10 402 145525 214848 29213752
Cytomegalovirus test positive 267.65 11.10 182 145745 3241 29425359
Brain abscess 256.09 11.10 161 145766 2494 29426106
Nausea 253.32 11.10 669 145258 288586 29140014
Hepatitis C 246.23 11.10 260 145667 8650 29419950
Heart transplant rejection 245.72 11.10 118 145809 1033 29427567
Death 238.98 11.10 877 145050 341207 29087393
Constipation 238.95 11.10 133 145794 114027 29314573
Graft loss 237.60 11.10 105 145822 743 29427857
Septic shock 227.85 11.10 753 145174 61807 29366793
Haemophagocytic lymphohistiocytosis 227.62 11.10 270 145657 10234 29418366
Epstein-Barr virus associated lymphoproliferative disorder 226.62 11.10 128 145799 1610 29426990
Myocardial infarction 223.00 11.10 134 145793 110162 29318438
Actinic keratosis 221.96 11.10 169 145758 3617 29424983
JC virus infection 221.45 11.10 130 145797 1767 29426833
Rash 219.44 11.10 375 145552 189444 29239156
Arthralgia 217.39 11.10 221 145706 139396 29289204
Pneumonia cytomegaloviral 215.42 11.10 145 145782 2537 29426063
Pulmonary nocardiosis 214.85 11.10 87 145840 480 29428120
Meningitis cryptococcal 209.23 11.10 130 145797 1970 29426630
Cystitis haemorrhagic 207.47 11.10 180 145747 4662 29423938
Leukopenia 205.97 11.10 670 145257 54533 29374067
Human herpesvirus 8 infection 202.84 11.10 94 145833 753 29427847
Malignant neoplasm progression 202.01 11.10 57 145870 73802 29354798
Blood creatinine increased 200.73 11.10 892 145035 84210 29344390
Acute graft versus host disease in intestine 198.72 11.10 131 145796 2210 29426390
Renal tubular necrosis 197.50 11.10 295 145632 14020 29414580
Fungal infection 197.43 11.10 288 145639 13397 29415203
Cytomegalovirus colitis 197.15 11.10 133 145794 2336 29426264
Diffuse large B-cell lymphoma 196.72 11.10 196 145731 6080 29422520
Lung transplant rejection 194.36 11.10 87 145840 637 29427963
Hypotension 194.06 11.10 419 145508 193935 29234665
Polyomavirus viraemia 193.65 11.10 84 145843 565 29428035
Escherichia infection 193.37 11.10 201 145726 6563 29422037
Cryptosporidiosis infection 189.61 11.10 73 145854 344 29428256
Viraemia 187.42 11.10 96 145831 978 29427622
Varicella zoster virus infection 185.71 11.10 106 145821 1362 29427238
Pneumatosis intestinalis 184.77 11.10 141 145786 3028 29425572
Epstein-Barr viraemia 184.05 11.10 92 145835 886 29427714
Malaise 183.73 11.10 316 145611 159286 29269314
Product dose omission issue 182.64 11.10 126 145801 96257 29332343
Cytomegalovirus infection reactivation 181.61 11.10 143 145784 3221 29425379
Pain in extremity 180.90 11.10 167 145760 110266 29318334
Anxiety 180.67 11.10 98 145829 85267 29343333
Neurotoxicity 180.34 11.10 286 145641 14327 29414273
Syncope 180.27 11.10 88 145839 81283 29347317
Somnolence 176.47 11.10 124 145803 93831 29334769
Infection reactivation 174.87 11.10 92 145835 995 29427605
Scedosporium infection 172.21 11.10 82 145845 703 29427897
Drug hypersensitivity 170.73 11.10 62 145865 68344 29360256
Acute kidney injury 169.36 11.10 2025 143902 263242 29165358
Dermatophytosis 169.12 11.10 57 145870 166 29428434
Fungal skin infection 167.56 11.10 119 145808 2279 29426321
Human polyomavirus infection 166.46 11.10 77 145850 614 29427986
West Nile viral infection 161.49 11.10 74 145853 576 29428024
Back pain 161.30 11.10 160 145767 102124 29326476
Toxoplasmosis 160.47 11.10 89 145838 1078 29427522
Depression 160.39 11.10 112 145815 85035 29343565
Lymphoproliferative disorder 159.71 11.10 118 145809 2409 29426191
Acute respiratory distress syndrome 158.54 11.10 350 145577 22585 29406015
Trichodysplasia spinulosa 155.32 11.10 55 145872 194 29428406
Alternaria infection 154.97 11.10 59 145868 268 29428332
Candida infection 154.52 11.10 273 145654 14952 29413648
Respiratory failure 152.10 11.10 908 145019 96223 29332377
Hyperhidrosis 151.98 11.10 64 145863 64476 29364124
Squamous cell carcinoma 149.70 11.10 217 145710 10034 29418566
Progressive multifocal leukoencephalopathy 145.84 11.10 197 145730 8522 29420078
Peripheral swelling 144.11 11.10 67 145860 63672 29364928
COVID-19 pneumonia 144.08 11.10 205 145722 9317 29419283
Post transplant distal limb syndrome 143.86 11.10 54 145873 234 29428366
Pruritus 143.11 11.10 222 145705 116627 29311973
Joint swelling 141.95 11.10 35 145892 49595 29379005
Proteinuria 140.96 11.10 268 145659 15536 29413064
Renal graft infection 140.06 11.10 51 145876 199 29428401
Feeling abnormal 138.15 11.10 48 145879 54397 29374203
Human herpesvirus 6 infection 136.09 11.10 95 145832 1768 29426832
Complications of transplanted liver 136.02 11.10 49 145878 184 29428416
Hepatic artery thrombosis 134.21 11.10 49 145878 193 29428407
Chronic graft versus host disease in skin 133.37 11.10 70 145857 753 29427847
Chest pain 133.09 11.10 217 145710 111756 29316844
Acinetobacter infection 132.53 11.10 75 145852 947 29427653
Aplasia pure red cell 132.14 11.10 149 145778 5342 29423258
Drug level fluctuating 129.07 11.10 58 145869 429 29428171
Cardiac failure congestive 128.70 11.10 113 145814 76468 29352132
Mycobacterium abscessus infection 126.50 11.10 56 145871 398 29428202
Blastomycosis 125.58 11.10 50 145877 262 29428338
Tubulointerstitial nephritis 125.05 11.10 272 145655 17371 29411229
Trichophytosis 124.70 11.10 48 145879 226 29428374
Lymphocele 124.03 11.10 79 145848 1253 29427347
Chronic obstructive pulmonary disease 122.87 11.10 26 145901 40929 29387671
Histoplasmosis 122.74 11.10 79 145848 1277 29427323
Neutrophil Pelger-Huet anomaly present 122.06 11.10 46 145881 202 29428398
Stenotrophomonas infection 121.80 11.10 86 145841 1631 29426969
Disease recurrence 121.64 11.10 253 145674 15661 29412939
Staphylococcal infection 121.03 11.10 368 145559 28872 29399728
Intentional overdose 120.76 11.10 22 145905 38506 29390094
Renal tubular injury 120.00 11.10 62 145865 644 29427956
Urticaria 119.68 11.10 60 145867 54600 29374000
Squamous cell carcinoma of skin 118.89 11.10 187 145740 9299 29419301
Acute graft versus host disease in liver 118.77 11.10 77 145850 1261 29427339
Mycobacterial infection 118.04 11.10 87 145840 1769 29426831
Encephalitis viral 117.67 11.10 72 145855 1060 29427540
Insomnia 117.12 11.10 160 145767 88601 29339999
Decreased appetite 116.54 11.10 350 145577 144992 29283608
Obliterative bronchiolitis 116.05 11.10 71 145856 1045 29427555
Injection site pain 114.53 11.10 13 145914 32433 29396167
Gastroenteritis norovirus 113.38 11.10 76 145851 1320 29427280
Hypersensitivity 112.96 11.10 60 145867 52843 29375757
Skin papilloma 111.27 11.10 82 145845 1667 29426933
Blood pressure increased 111.15 11.10 120 145807 73683 29354917
Suicide attempt 110.15 11.10 18 145909 34092 29394508
Graft versus host disease in lung 108.88 11.10 52 145875 449 29428151
Malacoplakia gastrointestinal 108.78 11.10 34 145893 71 29428529
Suicidal ideation 108.42 11.10 20 145907 34696 29393904
Venoocclusive liver disease 107.73 11.10 151 145776 6766 29421834
Malacoplakia 107.53 11.10 36 145891 102 29428498
Drug level decreased 107.31 11.10 143 145784 6104 29422496
Haemolytic uraemic syndrome 105.77 11.10 84 145843 1916 29426684
Epistaxis 105.54 11.10 62 145865 51642 29376958
Biliary anastomosis complication 103.69 11.10 33 145894 75 29428525
Bradycardia 103.01 11.10 103 145824 65526 29363074
International normalised ratio increased 102.85 11.10 45 145882 44327 29384273
Cerebrovascular accident 102.10 11.10 138 145789 76773 29351827
Rheumatoid arthritis 101.54 11.10 18 145909 32134 29396466
Renal transplant 101.01 11.10 75 145852 1543 29427057
Pancreas transplant rejection 100.70 11.10 37 145890 149 29428451
Rhodococcus infection 100.59 11.10 36 145891 132 29428468
Disseminated cryptococcosis 100.18 11.10 66 145861 1112 29427488
Muscle spasms 100.04 11.10 104 145823 64978 29363622
Neuropathy peripheral 99.90 11.10 122 145805 70905 29357695
Pyelonephritis 99.70 11.10 128 145799 5265 29423335
Nasopharyngitis 99.07 11.10 89 145838 59576 29369024
Epidermodysplasia verruciformis 98.18 11.10 33 145894 95 29428505
Infusion related reaction 97.84 11.10 47 145880 43839 29384761
Rhabdomyolysis 97.09 11.10 94 145833 60714 29367886
Angiosarcoma 96.71 11.10 40 145887 235 29428365
Diabetes mellitus 95.66 11.10 420 145507 39411 29389189
Complications of transplant surgery 95.44 11.10 47 145880 437 29428163
Encephalitis 95.17 11.10 137 145790 6293 29422307
Pulmonary mucormycosis 95.17 11.10 49 145878 505 29428095
Complications of transplanted heart 95.16 11.10 39 145888 223 29428377
Endophthalmitis 94.94 11.10 92 145835 2756 29425844
Pneumonia fungal 94.30 11.10 129 145798 5648 29422952
IgA nephropathy 94.19 11.10 61 145866 997 29427603
Osmotic demyelination syndrome 94.17 11.10 52 145875 624 29427976
Pathogen resistance 93.52 11.10 154 145773 7962 29420638
Hypoaesthesia 93.36 11.10 76 145851 53391 29375209
Heart rate decreased 93.11 11.10 8 145919 24904 29403696
Pneumonia cryptococcal 92.74 11.10 54 145873 722 29427878
Renal tubular acidosis 91.67 11.10 74 145853 1729 29426871
Loss of consciousness 91.27 11.10 140 145787 73916 29354684
Gait disturbance 91.04 11.10 138 145789 73211 29355389
Choroiditis 90.51 11.10 58 145869 930 29427670
Drug reaction with eosinophilia and systemic symptoms 89.87 11.10 15 145912 27977 29400623
Pancytopenia 89.36 11.10 709 145218 82459 29346141
Papilloma viral infection 88.90 11.10 44 145883 414 29428186
Blood creatine phosphokinase increased 88.38 11.10 45 145882 40599 29388001
Atrial fibrillation 87.09 11.10 251 145676 105395 29323205
Musculoskeletal stiffness 86.79 11.10 38 145889 37420 29391180
Ureteric stenosis 86.44 11.10 59 145868 1057 29427543
Complications of transplanted lung 85.46 11.10 33 145894 157 29428443
Hypoglycaemia 85.31 11.10 68 145859 48278 29380322
Histoplasmosis disseminated 85.12 11.10 59 145868 1085 29427515
Platelet count decreased 83.88 11.10 252 145675 104420 29324180
Weight increased 83.39 11.10 157 145770 76510 29352090
Anogenital warts 82.96 11.10 45 145882 520 29428080
Cerebral aspergillosis 82.74 11.10 62 145865 1294 29427306
Encapsulating peritoneal sclerosis 81.78 11.10 45 145882 536 29428064
Paraesthesia 80.55 11.10 88 145839 53757 29374843
Balance disorder 80.22 11.10 39 145888 36131 29392469
Enterobacter infection 79.92 11.10 72 145855 1962 29426638
Pulmonary embolism 79.54 11.10 161 145766 76373 29352227
Acute myocardial infarction 79.52 11.10 73 145854 48365 29380235
Inappropriate schedule of product administration 79.16 11.10 62 145865 44410 29384190
Glomerulonephritis 78.55 11.10 66 145861 1634 29426966
Graft versus host disease in liver 78.44 11.10 55 145872 1031 29427569
Epstein-Barr virus infection reactivation 78.38 11.10 43 145884 509 29428091
Acute myeloid leukaemia recurrent 77.93 11.10 67 145860 1713 29426887
Alveolar proteinosis 77.51 11.10 36 145891 290 29428310
Dermoid cyst 77.14 11.10 30 145897 146 29428454
Contraindicated product administered 76.95 11.10 3 145924 18263 29410337
Lymphopenia 76.56 11.10 191 145736 13342 29415258
Adenoviral haemorrhagic cystitis 76.10 11.10 38 145889 365 29428235
Post procedural bile leak 76.06 11.10 34 145893 248 29428352
Chronic hepatitis 75.13 11.10 42 145885 517 29428083
Pyelonephritis acute 74.98 11.10 64 145863 1620 29426980
Acanthamoeba infection 74.79 11.10 38 145889 380 29428220
Vomiting 74.10 11.10 680 145247 211580 29217020
Glomerulonephritis membranoproliferative 72.90 11.10 37 145890 369 29428231
Unevaluable event 72.85 11.10 28 145899 29823 29398777
Pneumonia klebsiella 72.76 11.10 77 145850 2567 29426033
Eczema herpeticum 72.67 11.10 27 145900 113 29428487
Food allergy 71.51 11.10 50 145877 933 29427667
Rectal haemorrhage 71.11 11.10 41 145886 34508 29394092
Cytomegalovirus gastritis 70.93 11.10 30 145897 188 29428412
Corynebacterium infection 70.74 11.10 37 145890 395 29428205
Wheezing 70.50 11.10 38 145889 33202 29395398
Pneumoperitoneum 70.48 11.10 60 145867 1513 29427087
Glomerulosclerosis 70.28 11.10 44 145883 676 29427924
Kaposi's sarcoma 70.18 11.10 47 145880 815 29427785
General physical health deterioration 69.87 11.10 266 145661 102591 29326009
Transplantation associated food allergy 69.80 11.10 20 145907 26 29428574
Donor specific antibody present 69.72 11.10 24 145903 76 29428524
Therapeutic product effect incomplete 69.69 11.10 55 145872 39250 29389350
Cerebral toxoplasmosis 69.64 11.10 57 145870 1359 29427241
Organising pneumonia 69.57 11.10 104 145823 4944 29423656
Non-cirrhotic portal hypertension 69.48 11.10 31 145896 225 29428375
Bacterial sepsis 69.30 11.10 100 145827 4603 29423997
Agitation 69.13 11.10 91 145836 51213 29377387
Pneumonia pseudomonal 68.75 11.10 83 145844 3204 29425396
Liver transplant 68.31 11.10 70 145857 2246 29426354
Hepatic fibrosis 67.82 11.10 82 145845 3170 29425430
Herpes simplex 67.75 11.10 101 145826 4789 29423811
Nephrotic syndrome 67.49 11.10 116 145811 6212 29422388
Hydronephrosis 66.95 11.10 139 145788 8591 29420009
Necrotising oesophagitis 66.86 11.10 38 145889 484 29428116
Oxygen saturation decreased 66.60 11.10 74 145853 44863 29383737
Renal artery stenosis 66.60 11.10 64 145863 1897 29426703
Wrong technique in product usage process 66.55 11.10 36 145891 31392 29397208
White blood cell count decreased 66.55 11.10 201 145726 83161 29345439
Aggression 66.54 11.10 47 145880 35494 29393106
American trypanosomiasis 66.52 11.10 30 145897 224 29428376
Coronary artery disease 66.34 11.10 72 145855 44118 29384482
Erythema infectiosum 65.18 11.10 26 145901 137 29428463
Sepsis 65.16 11.10 1027 144900 141655 29286945
Blood pressure decreased 65.11 11.10 77 145850 45400 29383200
Osteomyelitis fungal 64.82 11.10 29 145898 212 29428388
Dysgeusia 64.79 11.10 16 145911 22658 29405942
Disseminated varicella zoster virus infection 64.72 11.10 26 145901 140 29428460
Central nervous system lymphoma 64.56 11.10 42 145885 692 29427908
Pneumocystis jirovecii infection 64.41 11.10 55 145872 1393 29427207
Neutrophil count decreased 64.28 11.10 72 145855 43495 29385105
Bacterial infection 64.26 11.10 174 145753 12774 29415826
Ascites 64.20 11.10 353 145574 36266 29392334
Bile duct stenosis 64.10 11.10 50 145877 1110 29427490
Angioedema 64.09 11.10 39 145888 31876 29396724
Mycobacterium chelonae infection 64.04 11.10 39 145888 569 29428031
Contusion 63.85 11.10 37 145890 31058 29397542
Drug dependence 63.58 11.10 13 145914 20968 29407632
Chest discomfort 63.57 11.10 80 145847 45903 29382697
Cytomegalovirus oesophagitis 63.50 11.10 34 145893 382 29428218
Disseminated mucormycosis 63.50 11.10 32 145895 314 29428286
Asthma 63.05 11.10 45 145882 33804 29394796
Meningitis viral 63.01 11.10 43 145884 770 29427830
Graft complication 62.98 11.10 32 145895 320 29428280
Meningoencephalitis herpetic 62.77 11.10 42 145885 727 29427873
Systemic mycosis 62.51 11.10 52 145875 1269 29427331
Abdominal discomfort 62.49 11.10 87 145840 47816 29380784
Histology abnormal 62.23 11.10 30 145897 265 29428335
Haemodialysis 62.21 11.10 146 145781 9808 29418792
Headache 61.75 11.10 555 145372 173452 29255148
Myalgia 61.60 11.10 175 145752 73844 29354756
Hepatic cancer recurrent 61.56 11.10 30 145897 272 29428328
Cytomegalovirus nephritis 61.21 11.10 23 145904 100 29428500
Ileal ulcer 61.21 11.10 36 145891 491 29428109
Heart rate increased 61.20 11.10 61 145866 38877 29389723
Drug resistance 61.02 11.10 239 145688 21301 29407299
Therapeutic product effect decreased 60.53 11.10 35 145892 29416 29399184
Bacterial pyelonephritis 60.45 11.10 28 145899 224 29428376
Loss of personal independence in daily activities 60.22 11.10 25 145902 25415 29403185
Smooth muscle cell neoplasm 59.93 11.10 24 145903 128 29428472
Periostitis 59.92 11.10 28 145899 229 29428371
Wound dehiscence 59.57 11.10 74 145853 2943 29425657
Pneumomediastinum 59.05 11.10 57 145870 1699 29426901
Pericarditis fungal 58.74 11.10 24 145903 136 29428464
Immune reconstitution inflammatory syndrome 58.40 11.10 123 145804 7679 29420921
Urinary tract infection bacterial 58.06 11.10 52 145875 1406 29427194
Chronic graft versus host disease in liver 57.78 11.10 30 145897 315 29428285
Polyomavirus test positive 57.77 11.10 22 145905 100 29428500
Intestine transplant rejection 57.73 11.10 17 145910 26 29428574
Cardio-respiratory arrest 57.34 11.10 101 145826 50500 29378100
Erythema 57.03 11.10 187 145740 75419 29353181
Dysplastic naevus 57.03 11.10 32 145895 397 29428203
Mobility decreased 56.86 11.10 28 145899 25752 29402848
Disease progression 56.82 11.10 210 145717 81706 29346894
Cardiac disorder 56.73 11.10 60 145867 37203 29391397
Primary effusion lymphoma 56.55 11.10 15 145912 11 29428589
Cytomegalovirus enteritis 56.54 11.10 32 145895 404 29428196
Cardiac failure 56.49 11.10 201 145726 79086 29349514
End stage renal disease 56.41 11.10 120 145807 7544 29421056
Oedema peripheral 56.31 11.10 291 145636 103266 29325334
Human herpesvirus 6 encephalitis 55.62 11.10 25 145902 185 29428415
Gastroenteritis sapovirus 55.45 11.10 22 145905 114 29428486
Memory impairment 55.21 11.10 59 145868 36411 29392189
Nodular regenerative hyperplasia 55.03 11.10 37 145890 646 29427954
Burkholderia cepacia complex infection 54.80 11.10 23 145904 141 29428459
Large intestinal ulcer 54.71 11.10 54 145873 1655 29426945
Hepatic artery stenosis 54.68 11.10 22 145905 119 29428481
Arthropathy 54.65 11.10 19 145908 21535 29407065
Dehydration 54.52 11.10 337 145590 114411 29314189
Cytomegalovirus gastrointestinal infection 54.40 11.10 24 145903 169 29428431
Sedation 54.40 11.10 10 145917 17395 29411205
Urinoma 54.05 11.10 24 145903 172 29428428
Cytomegalovirus enterocolitis 53.72 11.10 39 145888 774 29427826
Palpitations 53.67 11.10 49 145878 32555 29396045
Hallucination 53.66 11.10 86 145841 44626 29383974
Confusional state 53.54 11.10 390 145537 127487 29301113
Flushing 53.40 11.10 39 145888 28953 29399647
Biliary tract disorder 53.13 11.10 38 145889 736 29427864
Coronavirus infection 53.03 11.10 73 145854 3215 29425385
Viral haemorrhagic cystitis 52.99 11.10 41 145886 899 29427701
Clostridium difficile colitis 52.52 11.10 164 145763 13048 29415552
Epstein-Barr virus test positive 52.12 11.10 32 145895 474 29428126
Cholangitis 52.04 11.10 115 145812 7422 29421178
Lung transplant 51.66 11.10 53 145874 1703 29426897
Microsporidia infection 51.45 11.10 33 145894 530 29428070
Mycetoma mycotic 51.15 11.10 18 145909 62 29428538
Upper gastrointestinal haemorrhage 51.12 11.10 22 145905 21892 29406708
Oliguria 51.07 11.10 113 145814 7299 29421301
Liver transplant failure 51.05 11.10 19 145908 80 29428520
Cytomegalovirus chorioretinitis 50.89 11.10 71 145856 3167 29425433
Injection site erythema 50.76 11.10 5 145922 13951 29414649
Gingival hypertrophy 50.34 11.10 51 145876 1614 29426986
Engraftment syndrome 50.23 11.10 38 145889 805 29427795
Overdose 50.03 11.10 213 145714 79606 29348994
Mediastinitis 49.91 11.10 34 145893 607 29427993
Escherichia urinary tract infection 49.81 11.10 68 145859 2971 29425629
Photodermatosis 49.78 11.10 30 145897 429 29428171
Stress 49.46 11.10 22 145905 21468 29407132
Steroid diabetes 49.43 11.10 51 145876 1650 29426950
Nephropathy 49.09 11.10 91 145836 5172 29423428
Respiratory arrest 48.57 11.10 34 145893 25799 29402801
Choriomeningitis lymphocytic 48.52 11.10 14 145913 19 29428581
Portal vein thrombosis 48.23 11.10 70 145857 3239 29425361
Drug level above therapeutic 48.22 11.10 70 145857 3240 29425360
Urinary fistula 48.12 11.10 19 145908 97 29428503
Demodicidosis 48.01 11.10 20 145907 120 29428480
Dermatitis atopic 48.00 11.10 57 145870 2162 29426438
Liver abscess 47.77 11.10 70 145857 3268 29425332
Toxic optic neuropathy 47.72 11.10 35 145892 706 29427894
Chills 47.36 11.10 186 145741 71114 29357486
Diaphragmatic hernia 47.32 11.10 24 145903 239 29428361
Hyperkalaemia 47.26 11.10 487 145440 60905 29367695
Skin necrosis 47.18 11.10 87 145840 4925 29423675
Atypical mycobacterial infection 47.17 11.10 34 145893 667 29427933
Emphysematous pyelonephritis 47.16 11.10 15 145912 34 29428566
Solar lentigo 47.16 11.10 28 145899 389 29428211
Atypical mycobacterial pneumonia 47.06 11.10 20 145907 127 29428473
Bacteraemia 46.95 11.10 182 145745 16141 29412459
Gastroenteritis cryptosporidial 46.77 11.10 21 145906 155 29428445
Cutaneous malacoplakia 46.57 11.10 15 145912 36 29428564
Hypogammaglobulinaemia 46.41 11.10 95 145832 5812 29422788
Hypokalaemia 46.08 11.10 113 145814 50090 29378510
Scleroderma 46.07 11.10 44 145883 1294 29427306
Flatulence 45.97 11.10 15 145912 17694 29410906
Hepatocellular carcinoma 45.92 11.10 105 145822 6933 29421667
Bacillary angiomatosis 44.95 11.10 18 145909 96 29428504
Neck pain 44.77 11.10 25 145902 21422 29407178
Oesophageal achalasia 44.77 11.10 25 145902 307 29428293
Dry mouth 44.61 11.10 26 145901 21758 29406842
Enterococcal bacteraemia 44.61 11.10 46 145881 1487 29427113
Heartland virus infection 44.57 11.10 12 145915 10 29428590
Prostatic specific antigen increased 44.42 11.10 5 145922 12559 29416041
Cholangitis sclerosing 44.37 11.10 39 145888 1028 29427572
Full blood count decreased 44.32 11.10 12 145915 15980 29412620
Full blood count abnormal 44.07 11.10 10 145917 15003 29413597
Morganella infection 44.02 11.10 28 145899 443 29428157
Encephalopathy 43.96 11.10 283 145644 30760 29397840
Mycoplasma infection 43.75 11.10 24 145903 284 29428316
Orf 43.35 11.10 13 145914 22 29428578
Gastrooesophageal reflux disease 43.31 11.10 55 145872 31441 29397159
Transient ischaemic attack 43.25 11.10 31 145896 23239 29405361
Intentional product misuse 43.18 11.10 65 145862 34596 29394004
Idiopathic pneumonia syndrome 42.96 11.10 22 145905 224 29428376
Fungal endocarditis 42.38 11.10 23 145904 266 29428334
Sopor 42.29 11.10 3 145924 10931 29417669
Heart rate irregular 42.16 11.10 7 145920 13110 29415490
Drug withdrawal syndrome 42.04 11.10 18 145909 17966 29410634
Meningoencephalitis viral 42.01 11.10 18 145909 117 29428483
Blood pressure fluctuation 41.81 11.10 23 145904 19871 29408729
Haematemesis 41.74 11.10 36 145891 24590 29404010
Intentional self-injury 41.53 11.10 6 145921 12455 29416145
Hot flush 41.51 11.10 11 145916 14859 29413741
Thyroid gland abscess 41.30 11.10 15 145912 58 29428542
Anuria 41.27 11.10 122 145805 9419 29419181
Plasma cell myeloma 41.22 11.10 75 145852 37040 29391560
Chronic hepatitis C 41.21 11.10 24 145903 321 29428279
Staphylococcal bacteraemia 41.19 11.10 101 145826 6978 29421622
Bone marrow transplant rejection 40.98 11.10 20 145907 182 29428418
Osteoarthritis 40.93 11.10 19 145908 18084 29410516
Chronic kidney disease 40.46 11.10 313 145614 36103 29392497
Central nervous system infection 40.44 11.10 28 145899 514 29428086
Tularaemia 40.31 11.10 16 145911 83 29428517
Infectious thyroiditis 40.16 11.10 16 145911 84 29428516
Disseminated intravascular coagulation 40.10 11.10 200 145727 19780 29408820
Drug level below therapeutic 40.03 11.10 74 145853 4197 29424403
Graft versus host disease in eye 40.00 11.10 21 145906 226 29428374
Optic atrophy 39.85 11.10 32 145895 742 29427858
Cutaneous T-cell lymphoma 39.81 11.10 40 145887 1253 29427347
Febrile neutropenia 39.75 11.10 358 145569 111882 29316718
Transplantation complication 39.70 11.10 16 145911 87 29428513
Tremor 39.67 11.10 545 145382 72993 29355607
Blood potassium decreased 39.67 11.10 14 145913 15720 29412880
Weight decreased 39.54 11.10 516 145411 150389 29278211
Osteonecrosis of jaw 39.44 11.10 16 145911 16494 29412106
Vascular hyalinosis 39.41 11.10 12 145915 22 29428578
Emphysematous cystitis 39.40 11.10 14 145913 50 29428550
Renal vein thrombosis 39.29 11.10 18 145909 140 29428460
Microangiopathy 39.16 11.10 32 145895 761 29427839
New onset diabetes after transplantation 39.07 11.10 12 145915 23 29428577
Erectile dysfunction 39.05 11.10 20 145907 17989 29410611
Tachycardia 39.04 11.10 204 145723 72206 29356394
Autoimmune haemolytic anaemia 39.03 11.10 69 145858 3779 29424821
Capillaritis 38.97 11.10 16 145911 92 29428508
Urinary tract infection viral 38.73 11.10 12 145915 24 29428576
Graft thrombosis 38.61 11.10 21 145906 244 29428356
Opportunistic infection 38.57 11.10 42 145885 1447 29427153
Dyspnoea exertional 38.54 11.10 76 145851 36414 29392186
Cytomegalovirus hepatitis 38.32 11.10 22 145905 286 29428314
Laboratory test abnormal 38.25 11.10 21 145906 18164 29410436
Herpes zoster meningoencephalitis 38.17 11.10 21 145906 250 29428350
Tick-borne viral encephalitis 38.09 11.10 11 145916 15 29428585
Ventricular remodelling 38.08 11.10 15 145912 76 29428524
Drug ineffective for unapproved indication 38.08 11.10 155 145772 14059 29414541
Gastroenteritis adenovirus 38.03 11.10 17 145910 124 29428476
Nasal congestion 38.00 11.10 23 145904 18856 29409744
Herpes zoster cutaneous disseminated 37.93 11.10 18 145909 153 29428447
Perinephric collection 37.83 11.10 18 145909 154 29428446
Abnormal behaviour 37.77 11.10 35 145892 23092 29405508
Herpes simplex hepatitis 37.77 11.10 15 145912 78 29428522
Cerebral fungal infection 37.72 11.10 20 145907 220 29428380
Philadelphia positive chronic myeloid leukaemia 37.61 11.10 15 145912 79 29428521
Fungaemia 37.57 11.10 50 145877 2131 29426469
Cytomegalovirus gastroenteritis 37.48 11.10 19 145908 189 29428411
Transitional cell carcinoma 37.46 11.10 47 145880 1888 29426712
Musculoskeletal pain 37.33 11.10 53 145874 28900 29399700
Arthritis 37.28 11.10 41 145886 24978 29403622
Anastomotic stenosis 37.11 11.10 21 145906 265 29428335
Cystitis viral 36.96 11.10 26 145901 490 29428110
Biloma 36.88 11.10 14 145913 63 29428537
Urinary tract infection enterococcal 36.74 11.10 31 145896 772 29427828
Post procedural urine leak 36.70 11.10 17 145910 136 29428464
Blood glucose increased 36.58 11.10 158 145769 58826 29369774
Enterococcal sepsis 36.55 11.10 41 145886 1461 29427139
BK polyomavirus test positive 36.54 11.10 11 145916 19 29428581
Presyncope 36.20 11.10 17 145910 16072 29412528
Adverse drug reaction 36.19 11.10 39 145888 23981 29404619
Mycobacterium avium complex infection 36.03 11.10 50 145877 2219 29426381
Klebsiella sepsis 36.00 11.10 43 145884 1641 29426959
Venoocclusive disease 35.98 11.10 53 145874 2486 29426114
Respiratory depression 35.91 11.10 11 145916 13512 29415088
Injection site reaction 35.90 11.10 6 145921 11182 29417418
Aspergilloma 35.86 11.10 21 145906 284 29428316
Oxalosis 35.84 11.10 11 145916 21 29428579
Peritonitis pneumococcal 35.84 11.10 11 145916 21 29428579
Inferior vena cava stenosis 35.84 11.10 11 145916 21 29428579
Granuloma 35.73 11.10 52 145875 2412 29426188
Sinusitis aspergillus 35.69 11.10 14 145913 70 29428530
Muscular weakness 35.63 11.10 171 145756 61881 29366719
Skin squamous cell carcinoma recurrent 35.59 11.10 12 145915 35 29428565
Oropharyngeal pain 35.44 11.10 56 145871 29229 29399371
Bronchitis 35.41 11.10 81 145846 36787 29391813
Swelling face 35.41 11.10 29 145898 20321 29408279
Aortic pseudoaneurysm 35.34 11.10 12 145915 36 29428564
Muir-Torre syndrome 35.34 11.10 10 145917 12 29428588
Labelled drug-drug interaction medication error 35.32 11.10 136 145791 12023 29416577
Injection site swelling 35.25 11.10 3 145924 9414 29419186
Serratia infection 35.16 11.10 29 145898 699 29427901
Orthostatic hypotension 34.93 11.10 36 145891 22593 29406007
Neurological symptom 34.92 11.10 61 145866 3309 29425291
Angina pectoris 34.91 11.10 52 145875 27798 29400802
Thrombosis 34.89 11.10 103 145824 42942 29385658
Neuroendocrine carcinoma of the skin 34.86 11.10 27 145900 593 29428007
Cough 34.80 11.10 429 145498 126298 29302302
Chronic myeloid leukaemia 34.79 11.10 46 145881 1948 29426652
Fusarium infection 34.73 11.10 33 145894 964 29427636
Biopsy kidney abnormal 34.69 11.10 15 145912 100 29428500
Prostate cancer 34.66 11.10 45 145882 25482 29403118
Dengue fever 34.59 11.10 18 145909 190 29428410
H1N1 influenza 34.58 11.10 31 145896 839 29427761
Hyponatraemia 34.55 11.10 194 145733 67439 29361161
Purtscher retinopathy 34.53 11.10 8 145919 0 29428600
Irritability 34.47 11.10 35 145892 22117 29406483
Serum sickness 34.38 11.10 43 145884 1722 29426878
Tinnitus 34.37 11.10 17 145910 15597 29413003
Postoperative wound infection 34.32 11.10 69 145858 4167 29424433
Intestinal tuberculosis 34.31 11.10 14 145913 79 29428521
Mycobacterium haemophilum infection 34.27 11.10 11 145916 26 29428574
Road traffic accident 34.16 11.10 17 145910 15544 29413056
Vision blurred 34.13 11.10 94 145833 40082 29388518
Trichosporon infection 34.10 11.10 27 145900 613 29427987
Pleocytosis 33.91 11.10 24 145903 457 29428143
Hyperplasia 33.76 11.10 25 145902 512 29428088
Eye abscess 33.52 11.10 16 145911 138 29428462
Superinfection bacterial 33.50 11.10 28 145899 688 29427912
Rhinorrhoea 33.48 11.10 34 145893 21485 29407115
Electrocardiogram QT prolonged 33.43 11.10 81 145846 36056 29392544
Dyspepsia 33.34 11.10 61 145866 30064 29398536
C3 glomerulopathy 33.32 11.10 10 145917 17 29428583
Pharyngeal polyp 33.16 11.10 9 145918 8 29428592
Passenger lymphocyte syndrome 33.16 11.10 11 145916 30 29428570
Adverse event 33.13 11.10 17 145910 15274 29413326
Anaphylactic reaction 33.11 11.10 53 145874 27520 29401080
Sleep disorder 33.10 11.10 43 145884 24343 29404257
Fungal abscess central nervous system 33.06 11.10 14 145913 88 29428512
Arteritis infective 32.96 11.10 10 145917 18 29428582
Prophylaxis against transplant rejection 32.96 11.10 10 145917 18 29428582
Protothecosis 32.90 11.10 11 145916 31 29428569
Chimerism 32.81 11.10 18 145909 213 29428387
Granulomatous dermatitis 32.74 11.10 18 145909 214 29428386
Nightmare 32.73 11.10 8 145919 11409 29417191
Endocarditis 32.67 11.10 81 145846 5635 29422965
Lethargy 32.62 11.10 87 145840 37493 29391107
Diabetic cardiomyopathy 32.61 11.10 10 145917 19 29428581
Pneumopericardium 32.54 11.10 14 145913 92 29428508
Renal lymphocele 32.53 11.10 12 145915 49 29428551
Enteritis 32.44 11.10 90 145837 6701 29421899
Inflammatory bowel disease 32.40 11.10 48 145879 2263 29426337
Abdominal distension 32.27 11.10 117 145810 45794 29382806
Central nervous system lesion 32.24 11.10 80 145847 5568 29423032
Gastric haemorrhage 32.12 11.10 4 145923 9293 29419307
Skin discolouration 32.11 11.10 18 145909 15391 29413209
Injury 32.09 11.10 28 145899 19018 29409582
Cholestasis 32.06 11.10 212 145715 23250 29405350
Bronchiolitis obliterans syndrome 32.01 11.10 16 145911 154 29428446
Hepatitis C RNA increased 31.94 11.10 19 145908 265 29428335
Renal tubular disorder 31.86 11.10 68 145859 4284 29424316
Toxic skin eruption 31.83 11.10 5 145922 9752 29418848
Renal failure 31.81 11.10 788 145139 117811 29310789
Optic neuropathy 31.79 11.10 41 145886 1694 29426906
Nephritis haemorrhagic 31.72 11.10 9 145918 11 29428589
Angiosarcoma metastatic 31.72 11.10 9 145918 11 29428589
Glomerulonephritis membranous 31.68 11.10 31 145896 940 29427660
Serotonin syndrome 31.68 11.10 24 145903 17488 29411112
Drug level changed 31.41 11.10 20 145907 317 29428283
Cognitive disorder 31.32 11.10 42 145885 23457 29405143
Disseminated mycobacterium avium complex infection 31.26 11.10 12 145915 56 29428544
Portal vein occlusion 31.26 11.10 12 145915 56 29428544
Skin squamous cell carcinoma metastatic 31.24 11.10 11 145916 38 29428562
Skin laceration 31.23 11.10 8 145919 11054 29417546
Skin lesion 31.18 11.10 177 145750 18395 29410205
Dysphagia 31.16 11.10 152 145775 54774 29373826
Lymphocytic infiltration 31.12 11.10 25 145902 580 29428020
Diverticulitis intestinal perforated 31.05 11.10 10 145917 24 29428576
Mouth ulceration 31.04 11.10 117 145810 10238 29418362
Subcapsular renal haematoma 30.92 11.10 21 145906 373 29428227
Rib fracture 30.91 11.10 12 145915 12706 29415894
Infection in an immunocompromised host 30.86 11.10 25 145902 587 29428013
Psoriatic arthropathy 30.85 11.10 17 145910 14674 29413926
Postoperative thoracic procedure complication 30.76 11.10 10 145917 25 29428575
Tumour lysis syndrome 30.73 11.10 15 145912 13869 29414731
Gastrointestinal haemorrhage 30.69 11.10 248 145679 79285 29349315
Aspartate aminotransferase increased 30.68 11.10 171 145756 59554 29369046
Abdominal pain upper 30.59 11.10 176 145751 60817 29367783
Lung consolidation 30.46 11.10 73 145854 4970 29423630
Lip squamous cell carcinoma 30.43 11.10 12 145915 61 29428539
Acanthamoeba keratitis 30.22 11.10 7 145920 0 29428600
Oral hairy leukoplakia 30.22 11.10 7 145920 0 29428600
Acanthoma 30.22 11.10 10 145917 27 29428573
Cold sweat 30.08 11.10 4 145923 8838 29419762
Pneumonia bacterial 30.06 11.10 108 145819 9235 29419365
Bone pain 30.04 11.10 28 145899 18424 29410176
Pain in jaw 29.97 11.10 10 145917 11631 29416969
Burning sensation 29.93 11.10 21 145906 15917 29412683
Seroma 29.79 11.10 24 145903 559 29428041
Reactive gastropathy 29.78 11.10 15 145912 147 29428453
Gait inability 29.78 11.10 28 145899 18347 29410253
Palmar-plantar erythrodysaesthesia syndrome 29.68 11.10 18 145909 14741 29413859
Hepatic vein stenosis 29.54 11.10 8 145919 7 29428593
Hepatic vein occlusion 29.50 11.10 14 145913 119 29428481
Kidney rupture 29.49 11.10 16 145911 185 29428415
Neoplasm progression 29.42 11.10 29 145898 18583 29410017
Pulmonary mass 29.42 11.10 118 145809 10630 29417970
Muscle abscess 29.40 11.10 22 145905 458 29428142
Stevens-Johnson syndrome 29.34 11.10 23 145904 16474 29412126
Guillain-Barre syndrome 29.25 11.10 72 145855 4986 29423614
Adult T-cell lymphoma/leukaemia 29.20 11.10 14 145913 122 29428478
Head injury 29.14 11.10 22 145905 16059 29412541
Herpes virus infection 29.12 11.10 48 145879 2483 29426117
Swollen tongue 29.11 11.10 12 145915 12254 29416346
Dysphonia 29.11 11.10 31 145896 19165 29409435
Restlessness 29.09 11.10 40 145887 22105 29406495
Varicella 29.07 11.10 36 145891 1427 29427173
Glomerulonephritis proliferative 29.05 11.10 16 145911 191 29428409
Ejection fraction decreased 28.77 11.10 22 145905 15956 29412644
Coma 28.75 11.10 99 145828 39351 29389249
Ureteral necrosis 28.74 11.10 10 145917 33 29428567
Hepatic failure 28.68 11.10 259 145668 31253 29397347
Dyskinesia 28.67 11.10 34 145893 20027 29408573
Urosepsis 28.64 11.10 117 145810 10629 29417971
Graft infection 28.52 11.10 20 145907 375 29428225
Pneumonia influenzal 28.50 11.10 34 145893 1296 29427304
Chronic myelomonocytic leukaemia 28.47 11.10 23 145904 538 29428062
Parvovirus infection 28.45 11.10 21 145906 428 29428172
Mucosal hypertrophy 28.42 11.10 9 145918 20 29428580
Gastrointestinal mucormycosis 28.39 11.10 13 145914 101 29428499
Prostatitis 28.38 11.10 68 145859 4629 29423971
B-cell lymphoma 28.35 11.10 60 145867 3758 29424842
Klebsiella bacteraemia 28.29 11.10 31 145896 1076 29427524
Paranoia 28.16 11.10 7 145920 9870 29418730
Blood pressure systolic increased 28.09 11.10 25 145902 16820 29411780
Incision site pain 27.88 11.10 39 145888 1744 29426856
Necrotising retinitis 27.86 11.10 26 145901 742 29427858
Abdominal wall abscess 27.83 11.10 21 145906 443 29428157
Hepatitis cholestatic 27.80 11.10 86 145841 6807 29421793
Epstein-Barr virus associated lymphoma 27.80 11.10 23 145904 557 29428043
Drug eruption 27.74 11.10 25 145902 16716 29411884
Burkholderia cepacia complex sepsis 27.73 11.10 7 145920 3 29428597
Cryoglobulinaemia 27.70 11.10 18 145909 296 29428304
Perinephric abscess 27.67 11.10 10 145917 38 29428562
Human herpesvirus 6 infection reactivation 27.65 11.10 13 145914 108 29428492
Basal cell carcinoma 27.63 11.10 160 145767 16750 29411850
Anaplastic large cell lymphoma T- and null-cell types 27.63 11.10 12 145915 81 29428519
Underdose 27.55 11.10 12 145915 11857 29416743
Chemical peritonitis 27.44 11.10 13 145914 110 29428490
Withdrawal syndrome 27.34 11.10 10 145917 10982 29417618
Portal fibrosis 27.33 11.10 18 145909 303 29428297
Faeces discoloured 27.24 11.10 16 145911 13335 29415265
Anaphylactic shock 27.19 11.10 16 145911 13320 29415280
Meningoencephalitis amoebic 27.15 11.10 13 145914 113 29428487
Haemoglobin decreased 27.12 11.10 374 145553 108001 29320599
Systemic candida 27.11 11.10 49 145878 2731 29425869
Hypoacusis 27.08 11.10 19 145908 14404 29414196
Ecthyma 27.01 11.10 19 145908 358 29428242
Dry skin 26.87 11.10 46 145881 23261 29405339
Toxic epidermal necrolysis 26.77 11.10 30 145897 18123 29410477
Renal arteriosclerosis 26.76 11.10 13 145914 117 29428483
Foetal exposure during pregnancy 26.76 11.10 82 145845 33785 29394815
Pulmonary tuberculosis 26.64 11.10 63 145864 4252 29424348
Human ehrlichiosis 26.60 11.10 15 145912 188 29428412
Atypical haemolytic uraemic syndrome 26.56 11.10 14 145913 152 29428448
Haemodynamic instability 26.55 11.10 94 145833 7979 29420621
Isosporiasis 26.54 11.10 11 145916 65 29428535
Viral test positive 26.53 11.10 15 145912 189 29428411
Emotional distress 26.50 11.10 18 145909 13877 29414723
Disseminated tuberculosis 26.43 11.10 40 145887 1922 29426678
Miosis 26.36 11.10 4 145923 8005 29420595
Central nervous system fungal infection 26.34 11.10 18 145909 323 29428277
Chromoblastomycosis 26.34 11.10 10 145917 45 29428555
Immune-mediated adverse reaction 26.30 11.10 20 145907 427 29428173
Dehiscence 26.27 11.10 11 145916 67 29428533
Wound infection 26.25 11.10 77 145850 5919 29422681
Low birth weight baby 26.24 11.10 82 145845 6526 29422074
Candida sepsis 26.21 11.10 30 145897 1093 29427507
Product prescribing error 26.19 11.10 30 145897 17946 29410654
Arrhythmia 26.05 11.10 74 145853 31239 29397361
Stem cell transplant 26.05 11.10 40 145887 1947 29426653
Metastatic squamous cell carcinoma 26.04 11.10 19 145908 380 29428220
Meningomyelitis herpes 26.03 11.10 9 145918 29 29428571
Body temperature decreased 26.02 11.10 10 145917 10654 29417946
Drug level abnormal 26.01 11.10 12 145915 95 29428505
Hepatosplenomegaly 25.98 11.10 57 145870 3660 29424940
Coccidioidomycosis 25.95 11.10 23 145904 613 29427987
Chronic graft versus host disease in intestine 25.93 11.10 15 145912 198 29428402
Pathergy reaction 25.91 11.10 7 145920 6 29428594
Hyperglycaemia 25.90 11.10 271 145656 34016 29394584
Cutaneous nocardiosis 25.85 11.10 13 145914 127 29428473
Amnesia 25.82 11.10 45 145882 22598 29406002
IVth nerve paralysis 25.80 11.10 12 145915 97 29428503
Obstructive nephropathy 25.80 11.10 9 145918 30 29428570
Legionella infection 25.75 11.10 20 145907 441 29428159
Neuroleptic malignant syndrome 25.71 11.10 25 145902 16123 29412477
Drug intolerance 25.68 11.10 137 145790 48242 29380358
Steatohepatitis 25.67 11.10 17 145910 289 29428311
Zoonotic bacterial infection 25.66 11.10 10 145917 49 29428551
Sebaceous carcinoma 25.61 11.10 11 145916 72 29428528
Toxicity to various agents 25.60 11.10 1074 144853 172587 29256013
Myelitis 25.57 11.10 24 145903 690 29427910
Feeling cold 25.28 11.10 7 145920 9184 29419416
Poor quality sleep 25.26 11.10 3 145924 7230 29421370
Angina unstable 25.19 11.10 11 145916 10854 29417746
Renal haematoma 25.08 11.10 20 145907 459 29428141
Dysarthria 25.02 11.10 74 145853 30837 29397763
Rash pruritic 25.00 11.10 45 145882 22318 29406282
Enterococcus test positive 24.98 11.10 24 145903 711 29427889
Disturbance in attention 24.96 11.10 42 145885 21382 29407218
Limbic encephalitis 24.93 11.10 18 145909 354 29428246
Bile duct necrosis 24.92 11.10 7 145920 8 29428592
Acarodermatitis 24.72 11.10 18 145909 359 29428241
Cutaneous blastomycosis 24.61 11.10 8 145919 20 29428580
Incorrect dose administered 24.56 11.10 82 145845 32902 29395698
Surgical procedure repeated 24.55 11.10 17 145910 312 29428288
Encephalitis cytomegalovirus 24.53 11.10 20 145907 474 29428126
Staphylococcal scalded skin syndrome 24.47 11.10 16 145911 266 29428334
T-cell lymphoma 24.37 11.10 26 145901 875 29427725
Influenza like illness 24.12 11.10 53 145874 24417 29404183
Retinitis 24.06 11.10 16 145911 274 29428326
Mycobacterium marinum infection 24.01 11.10 16 145911 275 29428325
Hepatitis C virus test 24.00 11.10 10 145917 60 29428540
Gastroenteritis eosinophilic 23.98 11.10 13 145914 150 29428450
Cell death 23.83 11.10 39 145888 2005 29426595
Sinusitis 23.83 11.10 88 145839 34262 29394338
Lymphangiectasia 23.81 11.10 8 145919 23 29428577
Blood immunoglobulin G decreased 23.80 11.10 29 145898 1130 29427470
Anger 23.75 11.10 12 145915 10878 29417722
Synovitis 23.75 11.10 12 145915 10878 29417722
Cyclosporidium infection 23.66 11.10 7 145920 11 29428589
Locked-in syndrome 23.65 11.10 15 145912 236 29428364
Cutaneous tuberculosis 23.64 11.10 11 145916 89 29428511
Ureteric anastomosis complication 23.62 11.10 9 145918 41 29428559
Evans syndrome 23.60 11.10 15 145912 237 29428363
Deep vein thrombosis 23.53 11.10 176 145751 57223 29371377
Feeling hot 23.50 11.10 25 145902 15463 29413137
Schistocytosis 23.48 11.10 6 145921 3 29428597
Cryptitis 23.45 11.10 9 145918 42 29428558
Odynophagia 23.41 11.10 63 145864 4607 29423993
Acinetobacter bacteraemia 23.33 11.10 11 145916 92 29428508
Hepatic necrosis 23.28 11.10 53 145874 3489 29425111
Sphincter of Oddi dysfunction 23.28 11.10 12 145915 124 29428476
Hypersomnia 23.23 11.10 12 145915 10742 29417858
Respiratory syncytial virus infection 23.22 11.10 54 145873 3605 29424995
Propionibacterium infection 23.22 11.10 15 145912 244 29428356
Lymphangitis 23.21 11.10 20 145907 513 29428087
Engraft failure 23.10 11.10 18 145909 399 29428201
Viral vasculitis 22.96 11.10 10 145917 68 29428532
Acquired porokeratosis 22.85 11.10 6 145921 4 29428596
Systemic bacterial infection 22.85 11.10 6 145921 4 29428596
Anhedonia 22.79 11.10 4 145923 7196 29421404
Subdural haematoma 22.77 11.10 34 145893 18159 29410441
Oligoarthritis 22.72 11.10 10 145917 70 29428530
Mycobacterium fortuitum infection 22.71 11.10 13 145914 168 29428432
Petechiae 22.71 11.10 7 145920 8564 29420036
Reversible cerebral vasoconstriction syndrome 22.70 11.10 15 145912 254 29428346
Adenoviral hepatitis 22.65 11.10 14 145913 210 29428390
Microsporum infection 22.64 11.10 8 145919 28 29428572
Pancreas transplant 22.64 11.10 8 145919 28 29428572
Phospholipidosis 22.63 11.10 9 145918 47 29428553
Chronic papillomatous dermatitis 22.47 11.10 9 145918 48 29428552
Eschar 22.46 11.10 21 145906 601 29427999
Device malfunction 22.44 11.10 7 145920 8500 29420100
Hypertensive emergency 22.39 11.10 24 145903 812 29427788
Extranodal marginal zone B-cell lymphoma (MALT type) 22.38 11.10 13 145914 173 29428427
Skin exfoliation 22.36 11.10 49 145878 22596 29406004
Depressed mood 22.32 11.10 29 145898 16419 29412181
Trichophytic granuloma 22.32 11.10 9 145918 49 29428551
Blister 22.30 11.10 40 145887 19866 29408734
Cyanosis 22.29 11.10 14 145913 11253 29417347
Histoplasmosis cutaneous 22.27 11.10 7 145920 15 29428585
Thrombotic thrombocytopenic purpura 22.22 11.10 49 145878 3157 29425443
Cow pox 22.22 11.10 8 145919 30 29428570
Swelling 22.18 11.10 94 145833 35189 29393411
Infective aneurysm 22.16 11.10 19 145908 484 29428116
Lymphadenopathy mediastinal 22.14 11.10 39 145888 2130 29426470
Oesophageal ulcer 21.98 11.10 48 145879 3072 29425528
Necrotising herpetic retinopathy 21.97 11.10 7 145920 16 29428584
Encephalitis protozoal 21.97 11.10 7 145920 16 29428584
Urinary retention 21.95 11.10 82 145845 31816 29396784
Milk allergy 21.80 11.10 10 145917 78 29428522
Pneumonia 21.80 11.10 1326 144601 318846 29109754
IIIrd nerve paralysis 21.79 11.10 18 145909 435 29428165
Visceral leishmaniasis 21.74 11.10 19 145908 497 29428103
Burkitt's lymphoma 21.73 11.10 11 145916 109 29428491
Complications of transplanted pancreas 21.68 11.10 7 145920 17 29428583
Depressed level of consciousness 21.67 11.10 101 145826 36841 29391759
Wound infection fungal 21.62 11.10 8 145919 33 29428567
Status epilepticus 21.62 11.10 108 145819 10686 29417914
Haemolytic anaemia 21.60 11.10 98 145829 9321 29419279
Immunosuppressant drug level 21.58 11.10 5 145922 0 29428600
Bile output increased 21.58 11.10 5 145922 0 29428600
Post procedural complication 21.56 11.10 105 145822 10284 29418316
Ureaplasma infection 21.44 11.10 13 145914 188 29428412
Hypertrophic cardiomyopathy 21.40 11.10 24 145903 855 29427745
Eye infection toxoplasmal 21.38 11.10 13 145914 189 29428411
Biliary ischaemia 21.29 11.10 6 145921 7 29428593
Fungal sepsis 21.27 11.10 23 145904 786 29427814
Abdominal infection 21.10 11.10 30 145897 1362 29427238
Penicillium infection 21.07 11.10 10 145917 85 29428515
Dementia 21.06 11.10 16 145911 11642 29416958
Disseminated cytomegaloviral infection 20.98 11.10 13 145914 196 29428404
Enterovirus infection 20.95 11.10 21 145906 656 29427944
Mood swings 20.94 11.10 5 145922 7246 29421354
Red blood cell count decreased 20.93 11.10 61 145866 25541 29403059
Herpes simplex test positive 20.92 11.10 13 145914 197 29428403
Oesophageal squamous cell carcinoma 20.87 11.10 16 145911 346 29428254
Renal adenoma 20.87 11.10 7 145920 20 29428580
Disseminated aspergillosis 20.81 11.10 17 145910 404 29428196
Hip fracture 20.81 11.10 13 145914 10479 29418121
Oesophageal perforation 20.80 11.10 22 145905 733 29427867
Diarrhoea haemorrhagic 20.71 11.10 70 145857 5804 29422796
Metabolic acidosis 20.65 11.10 280 145647 37382 29391218
Human herpes virus 8 test positive 20.62 11.10 7 145920 21 29428579
Incorrect route of product administration 20.59 11.10 14 145913 10787 29417813
Prostatic abscess 20.57 11.10 17 145910 411 29428189
Portal hypertension 20.56 11.10 50 145877 3436 29425164
Rabies 20.45 11.10 6 145921 9 29428591
Eosinophilic oesophagitis 20.42 11.10 13 145914 206 29428394
Disseminated Bacillus Calmette-Guerin infection 20.26 11.10 12 145915 166 29428434
Brain herniation 20.25 11.10 51 145876 3582 29425018
Limb discomfort 20.19 11.10 11 145916 9557 29419043
Body temperature increased 20.16 11.10 25 145902 14440 29414160
Tongue necrosis 20.14 11.10 7 145920 23 29428577
Nocturia 20.14 11.10 8 145919 8354 29420246
Tuberculosis of central nervous system 20.14 11.10 11 145916 129 29428471
Bone marrow transplant 20.09 11.10 24 145903 916 29427684
Disseminated trichosporonosis 20.08 11.10 8 145919 42 29428558
Pneumonia aspiration 20.07 11.10 103 145824 36634 29391966
Complications of bone marrow transplant 20.04 11.10 13 145914 213 29428387
Haematochezia 20.03 11.10 104 145823 36879 29391721
Sinus tachycardia 20.01 11.10 27 145900 15042 29413558
Nephritis 20.01 11.10 37 145890 2099 29426501
Lip swelling 20.01 11.10 19 145908 12391 29416209
Cryptococcal cutaneous infection 19.98 11.10 9 145918 67 29428533
Fear 19.95 11.10 11 145916 9493 29419107
Schistosomiasis 19.93 11.10 8 145919 43 29428557
C-reactive protein abnormal 19.90 11.10 4 145923 6532 29422068
Hepatitis B 19.82 11.10 66 145861 5431 29423169
Paraspinal abscess 19.75 11.10 9 145918 69 29428531
Salivary hypersecretion 19.72 11.10 6 145921 7403 29421197
Bronchial anastomosis complication 19.71 11.10 6 145921 11 29428589
Eye swelling 19.70 11.10 9 145918 8648 29419952
Incisional hernia 19.68 11.10 26 145901 1100 29427500
Hepatic haematoma 19.63 11.10 16 145911 379 29428221
Product quality issue 19.61 11.10 30 145897 15865 29412735
Joint injury 19.60 11.10 5 145922 6928 29421672
Abnormal dreams 19.54 11.10 5 145922 6915 29421685
Photosensitivity reaction 19.52 11.10 94 145833 9164 29419436
Renal and pancreas transplant rejection 19.49 11.10 7 145920 26 29428574
Urinary incontinence 19.48 11.10 32 145895 16449 29412151
Lactic acidosis 19.38 11.10 80 145847 30167 29398433
Ureteritis 19.37 11.10 6 145921 12 29428588
Electrocardiogram abnormal 19.36 11.10 6 145921 7316 29421284
Medication error 19.25 11.10 48 145879 21163 29407437
Arteriovenous fistula aneurysm 19.25 11.10 5 145922 3 29428597
Leuconostoc infection 19.25 11.10 5 145922 3 29428597
Red blood cell schistocytes present 19.23 11.10 13 145914 229 29428371
Contraindicated product prescribed 19.23 11.10 15 145912 333 29428267
Herpes zoster oticus 19.18 11.10 10 145917 106 29428494
Sleep apnoea syndrome 19.15 11.10 36 145891 17563 29411037
Accidental exposure to product 19.11 11.10 15 145912 10738 29417862
Pericardial fibrosis 19.09 11.10 7 145920 28 29428572
Peritonitis 19.08 11.10 132 145795 14692 29413908
Musculoskeletal discomfort 19.06 11.10 4 145923 6337 29422263
Eating disorder 19.05 11.10 6 145921 7241 29421359
Glomerulonephropathy 19.02 11.10 12 145915 187 29428413
Pollakiuria 18.94 11.10 34 145893 16882 29411718
Adenovirus reactivation 18.86 11.10 10 145917 110 29428490
Nephrolithiasis 18.85 11.10 63 145864 25271 29403329
Resting tremor 18.84 11.10 19 145908 598 29428002
Pericarditis infective 18.80 11.10 8 145919 51 29428549
Akathisia 18.79 11.10 5 145922 6737 29421863
Abscess fungal 18.77 11.10 11 145916 149 29428451
Central nervous system immune reconstitution inflammatory response 18.74 11.10 6 145921 14 29428586
Haemolysis 18.74 11.10 76 145851 6880 29421720
Troponin increased 18.74 11.10 11 145916 9172 29419428
Face oedema 18.72 11.10 14 145913 10269 29418331
Hepatitis B reactivation 18.71 11.10 46 145881 3183 29425417
Pneumonitis 18.71 11.10 73 145854 27971 29400629
Staphylococcal sepsis 18.70 11.10 90 145837 8772 29419828
Throat irritation 18.68 11.10 10 145917 8775 29419825
Peripheral coldness 18.61 11.10 4 145923 6232 29422368
Nervousness 18.59 11.10 17 145910 11289 29417311
Pharyngeal oedema 18.56 11.10 3 145924 5731 29422869
Vascular pseudoaneurysm 18.56 11.10 34 145893 1915 29426685
Chronic inflammatory demyelinating polyradiculoneuropathy 18.56 11.10 19 145908 609 29427991
Movement disorder 18.55 11.10 14 145913 10223 29418377
Ocular hyperaemia 18.53 11.10 11 145916 9116 29419484
Adenovirus test positive 18.53 11.10 7 145920 31 29428569
Hemianopia heteronymous 18.53 11.10 7 145920 31 29428569
Soft tissue mass 18.35 11.10 19 145908 617 29427983
Pyuria 18.35 11.10 19 145908 617 29427983
Gastritis fungal 18.34 11.10 9 145918 83 29428517
Sinusitis bacterial 18.25 11.10 14 145913 303 29428297
Metastases to lung 18.21 11.10 82 145845 7773 29420827
Red blood cell sedimentation rate increased 18.20 11.10 7 145920 7454 29421146
Argentine haemorrhagic fever 18.18 11.10 6 145921 16 29428584
Fluoride increased 18.17 11.10 8 145919 56 29428544
Pseudohypoaldosteronism 18.14 11.10 5 145922 5 29428595
Dysstasia 18.13 11.10 15 145912 10459 29418141
Stomatitis 18.12 11.10 108 145819 37005 29391595
Erythropoiesis abnormal 18.07 11.10 12 145915 205 29428395
Neutrophil morphology abnormal 18.05 11.10 8 145919 57 29428543
Pulmonary thrombosis 18.05 11.10 5 145922 6560 29422040
Intra-abdominal haemorrhage 18.03 11.10 35 145892 2060 29426540
Renal vessel disorder 18.02 11.10 12 145915 206 29428394
Limb injury 18.00 11.10 12 145915 9343 29419257
Hyperparathyroidism 17.97 11.10 25 145902 1112 29427488
Chromaturia 17.97 11.10 22 145905 12780 29415820
Metastasis 17.94 11.10 47 145880 3382 29425218
Eye infection fungal 17.94 11.10 14 145913 311 29428289
Central nervous system vasculitis 17.93 11.10 15 145912 369 29428231
Kaposi sarcoma inflammatory cytokine syndrome 17.92 11.10 6 145921 17 29428583
Necrosis 17.79 11.10 60 145867 4970 29423630
Dyslipidaemia 17.77 11.10 68 145859 5993 29422607
Hepatitis viral 17.74 11.10 17 145910 502 29428098
Gastric disorder 17.71 11.10 16 145911 10688 29417912
Metastatic malignant melanoma 17.71 11.10 32 145895 1783 29426817
Abscess 17.70 11.10 95 145832 9667 29418933
Cytomegalovirus gastrointestinal ulcer 17.69 11.10 7 145920 36 29428564
Radiculitis brachial 17.67 11.10 6 145921 18 29428582
Pericarditis constrictive 17.65 11.10 13 145914 264 29428336
Hypoaldosteronism 17.63 11.10 11 145916 168 29428432
Pyogenic granuloma 17.58 11.10 12 145915 215 29428385
Arteriovenous fistula thrombosis 17.56 11.10 14 145913 321 29428279
Pancreatitis necrotising 17.56 11.10 37 145890 2310 29426290
Escherichia sepsis 17.56 11.10 51 145876 3898 29424702
T-cell lymphoma stage IV 17.48 11.10 10 145917 129 29428471
Artery dissection 17.46 11.10 9 145918 93 29428507
Meningitis fungal 17.46 11.10 9 145918 93 29428507
Microtia 17.44 11.10 13 145914 269 29428331
Infected lymphocele 17.43 11.10 6 145921 19 29428581
Diffuse alveolar damage 17.42 11.10 34 145893 2009 29426591
Intraductal papillary mucinous neoplasm 17.38 11.10 14 145913 326 29428274
Encephalitis fungal 17.35 11.10 11 145916 173 29428427
Tooth disorder 17.31 11.10 13 145914 9516 29419084
Sinus bradycardia 17.30 11.10 19 145908 11584 29417016
Respiratory tract infection fungal 17.28 11.10 19 145908 662 29427938
Varicella virus test positive 17.27 11.10 8 145919 64 29428536
Interferon gamma decreased 17.27 11.10 4 145923 0 29428600
Cystitis glandularis 17.27 11.10 4 145923 0 29428600
Pallor 17.26 11.10 50 145877 20974 29407626
Cardiac valve vegetation 17.25 11.10 16 145911 453 29428147
Psoriasis 17.24 11.10 91 145836 32136 29396464
Small intestine gangrene 17.24 11.10 5 145922 7 29428593
Pneumonia proteus 17.24 11.10 5 145922 7 29428593
Reticulocytopenia 17.21 11.10 9 145918 96 29428504
Hepatic infection fungal 17.19 11.10 11 145916 176 29428424
Lymphorrhoea 17.17 11.10 8 145919 65 29428535
Speech disorder 17.14 11.10 59 145868 23457 29405143
Seizure 17.14 11.10 340 145587 92783 29335817
Segmented hyalinising vasculitis 17.08 11.10 7 145920 40 29428560
Epstein Barr virus positive mucocutaneous ulcer 17.04 11.10 13 145914 279 29428321
Bronchopneumopathy 17.01 11.10 15 145912 397 29428203
Brucellosis 16.98 11.10 6 145921 21 29428579
Panic attack 16.96 11.10 10 145917 8316 29420284
Escherichia bacteraemia 16.86 11.10 41 145886 2817 29425783
Hernial eventration 16.86 11.10 8 145919 68 29428532
Knee arthroplasty 16.79 11.10 4 145923 5805 29422795
Multimorbidity 16.78 11.10 17 145910 538 29428062
Gastroenteritis rotavirus 16.66 11.10 11 145916 186 29428414
Scrotal ulcer 16.65 11.10 14 145913 347 29428253
Pulmonary alveolar haemorrhage 16.63 11.10 69 145858 6311 29422289
Immune thrombocytopenia 16.62 11.10 80 145847 7797 29420803
Osteomyelitis chronic 16.62 11.10 12 145915 236 29428364
Large intestine infection 16.58 11.10 26 145901 1289 29427311
Fungating wound 16.56 11.10 6 145921 23 29428577
Restrictive allograft syndrome 16.56 11.10 6 145921 23 29428577
Ageusia 16.49 11.10 12 145915 8926 29419674
Nocardia sepsis 16.48 11.10 5 145922 9 29428591
Blood pressure diastolic decreased 16.46 11.10 7 145920 7015 29421585
Influenza 16.42 11.10 130 145797 41751 29386849
Hepatitis infectious mononucleosis 16.40 11.10 7 145920 45 29428555
Viral skin infection 16.40 11.10 7 145920 45 29428555
Cytomegalovirus mucocutaneous ulcer 16.37 11.10 8 145919 73 29428527
Middle insomnia 16.36 11.10 4 145923 5704 29422896
Skin abrasion 16.36 11.10 5 145922 6151 29422449
Hypocalcaemia 16.34 11.10 50 145877 20615 29407985
Bronchospasm 16.34 11.10 14 145913 9595 29419005
Parainfluenzae virus infection 16.30 11.10 35 145892 2214 29426386
Cutaneous mucormycosis 16.30 11.10 9 145918 108 29428492
Hallucination, auditory 16.28 11.10 14 145913 9579 29419021
Cerebral cyst 16.28 11.10 12 145915 244 29428356
Roseolovirus test positive 16.28 11.10 8 145919 74 29428526
Severe acute respiratory syndrome 16.27 11.10 7 145920 46 29428554
Procedural pneumothorax 16.27 11.10 7 145920 46 29428554
Sputum discoloured 16.27 11.10 6 145921 6557 29422043
Haemorrhage 16.27 11.10 143 145784 44929 29383671
Metastases to abdominal cavity 16.23 11.10 9 145918 109 29428491
Ventricular tachycardia 16.21 11.10 57 145870 22517 29406083
Acute disseminated encephalomyelitis 16.19 11.10 8 145919 75 29428525
Oesophageal stenosis 16.19 11.10 28 145899 1507 29427093
Pneumonia mycoplasmal 16.18 11.10 17 145910 562 29428038
Transitional cell carcinoma metastatic 16.17 11.10 6 145921 25 29428575
Urine output decreased 16.14 11.10 89 145838 9149 29419451
Adhesiolysis 16.14 11.10 5 145922 10 29428590
Nephrosclerosis 16.12 11.10 20 145907 794 29427806
Pseudomonal sepsis 16.09 11.10 41 145886 2901 29425699
Glomerulonephritis rapidly progressive 16.09 11.10 16 145911 495 29428105
Pneumonia adenoviral 16.07 11.10 10 145917 152 29428448
Uveitis 16.04 11.10 65 145862 5882 29422718
Tuberculosis gastrointestinal 16.02 11.10 11 145916 199 29428401
Vocal cord thickening 15.98 11.10 6 145921 26 29428574
Intraocular pressure increased 15.95 11.10 56 145871 4733 29423867
Fluid retention 15.92 11.10 61 145866 23499 29405101
Sporotrichosis 15.90 11.10 7 145920 49 29428551
Extrapyramidal disorder 15.86 11.10 18 145909 10813 29417787
Oral papilloma 15.82 11.10 5 145922 11 29428589
Transmission of an infectious agent via transplant 15.82 11.10 5 145922 11 29428589
Subcutaneous abscess 15.82 11.10 45 145882 3399 29425201
Cranial nerve paralysis 15.80 11.10 6 145921 27 29428573
Dyschromatopsia 15.74 11.10 13 145914 314 29428286
Cataract 15.74 11.10 57 145870 22321 29406279
NPM1 gene mutation 15.67 11.10 9 145918 117 29428483
Product dispensing error 15.67 11.10 61 145866 5419 29423181
Coronary artery occlusion 15.64 11.10 16 145911 10078 29418522
Laryngeal mass 15.63 11.10 6 145921 28 29428572
Wound 15.63 11.10 22 145905 12041 29416559
Alanine aminotransferase increased 15.60 11.10 251 145676 70693 29357907
Pneumonia viral 15.57 11.10 38 145889 2617 29425983
Psychotic disorder 15.57 11.10 50 145877 20304 29408296
Intussusception 15.55 11.10 16 145911 516 29428084
Sinus disorder 15.53 11.10 5 145922 5950 29422650
Tonsil cancer 15.51 11.10 21 145906 910 29427690
Cushingoid 15.49 11.10 36 145891 2402 29426198
Intracranial pressure increased 15.49 11.10 45 145882 3440 29425160
Cardiogenic shock 15.49 11.10 46 145881 19144 29409456
Keloid scar 15.46 11.10 6 145921 29 29428571
Gastroenteritis 15.46 11.10 111 145816 12505 29416095
Acute coronary syndrome 15.46 11.10 23 145904 12302 29416298
Retinal ischaemia 15.43 11.10 13 145914 323 29428277
White blood cell count increased 15.39 11.10 115 145812 37401 29391199
Microangiopathic haemolytic anaemia 15.34 11.10 20 145907 835 29427765
Myocarditis toxoplasmal 15.33 11.10 7 145920 54 29428546
Graft haemorrhage 15.33 11.10 7 145920 54 29428546
Granulomatous liver disease 15.30 11.10 16 145911 526 29428074
Papilloma 15.29 11.10 9 145918 123 29428477
Sinusitis fungal 15.28 11.10 14 145913 390 29428210
Immunosuppression 15.25 11.10 59 145868 5227 29423373
B-lymphocyte abnormalities 15.24 11.10 5 145922 13 29428587
Norovirus test positive 15.22 11.10 7 145920 55 29428545
Endocarditis enterococcal 15.17 11.10 8 145919 87 29428513
Blood creatinine abnormal 15.14 11.10 32 145895 2002 29426598
Arteriosclerosis coronary artery 15.12 11.10 18 145909 10587 29418013
Q fever 15.10 11.10 9 145918 126 29428474
Bacteriuria 15.06 11.10 12 145915 275 29428325
Sweat gland tumour 15.05 11.10 14 145913 398 29428202
Intracranial infection 15.04 11.10 4 145923 3 29428597
Disseminated varicella 15.04 11.10 4 145923 3 29428597
Yersinia infection 15.04 11.10 4 145923 3 29428597
Oesophageal compression 15.04 11.10 4 145923 3 29428597
Lymphadenitis fungal 15.04 11.10 4 145923 3 29428597
Escherichia test positive 14.98 11.10 22 145905 1029 29427571
Myocarditis infectious 14.98 11.10 5 145922 14 29428586
Leiomyosarcoma 14.98 11.10 9 145918 128 29428472
Sexual dysfunction 14.95 11.10 5 145922 5809 29422791
Hiccups 14.93 11.10 13 145914 8840 29419760
Quadriplegia 14.88 11.10 27 145900 1509 29427091
Bone disorder 14.83 11.10 5 145922 5778 29422822
Apoptosis 14.78 11.10 11 145916 227 29428373
Epstein-Barr virus antibody positive 14.77 11.10 12 145915 283 29428317
Lacrimation increased 14.77 11.10 8 145919 6972 29421628
Spontaneous intrahepatic portosystemic venous shunt 14.73 11.10 5 145922 15 29428585
Post streptococcal glomerulonephritis 14.68 11.10 6 145921 34 29428566
Anorectal varices 14.68 11.10 6 145921 34 29428566
Enterobacter pneumonia 14.68 11.10 6 145921 34 29428566
Gastroduodenal ulcer 14.65 11.10 13 145914 347 29428253
Acute hepatitis C 14.63 11.10 8 145919 94 29428506
Pleural effusion 14.55 11.10 461 145466 71447 29357153
Rash macular 14.54 11.10 18 145909 10407 29418193
Blood sodium decreased 14.54 11.10 32 145895 14735 29413865
Discomfort 14.53 11.10 32 145895 14731 29413869
Cytomegalovirus myocarditis 14.51 11.10 4 145923 4 29428596
Insulin resistant diabetes 14.51 11.10 4 145923 4 29428596
Anastomotic haemorrhage 14.50 11.10 9 145918 136 29428464
Genitourinary tract infection 14.49 11.10 8 145919 96 29428504
Sebaceous adenoma 14.49 11.10 5 145922 16 29428584
Red blood cells urine positive 14.46 11.10 28 145899 1645 29426955
Urethral stenosis 14.45 11.10 19 145908 800 29427800
Dermatitis allergic 14.44 11.10 5 145922 5683 29422917
Normocytic anaemia 14.44 11.10 31 145896 1961 29426639
Hyperparathyroidism secondary 14.43 11.10 24 145903 1251 29427349
Endothelial dysfunction 14.40 11.10 6 145921 36 29428564
Musculoskeletal disorder 14.39 11.10 4 145923 5236 29423364
Musculoskeletal chest pain 14.26 11.10 13 145914 8647 29419953
Biliary anastomosis 14.26 11.10 5 145922 17 29428583
Impaired work ability 14.25 11.10 5 145922 5635 29422965
Blood creatine increased 14.23 11.10 50 145877 4228 29424372
Citrobacter infection 14.21 11.10 14 145913 428 29428172
HLA marker study positive 14.20 11.10 8 145919 100 29428500
Cholelithiasis 14.19 11.10 46 145881 18626 29409974
Angioimmunoblastic T-cell lymphoma 14.18 11.10 12 145915 300 29428300
Lymph node tuberculosis 14.16 11.10 14 145913 430 29428170
Gastrointestinal toxicity 14.13 11.10 32 145895 2099 29426501
Tonsillar hypertrophy 14.11 11.10 16 145911 577 29428023
Red cell distribution width increased 14.09 11.10 3 145924 4704 29423896
Hepatitis A 14.05 11.10 14 145913 434 29428166
Inhibin B 14.04 11.10 5 145922 18 29428582
Renal cell carcinoma stage I 14.04 11.10 5 145922 18 29428582
Lung abscess 14.02 11.10 34 145893 2332 29426268
Granulocytopenia 14.01 11.10 6 145921 5988 29422612
Encephalitis autoimmune 13.96 11.10 15 145912 509 29428091
Oedema 13.93 11.10 130 145797 40353 29388247
Pulmonary congestion 13.92 11.10 25 145902 12411 29416189
B-lymphocyte count decreased 13.91 11.10 15 145912 511 29428089
Multiple sclerosis 13.90 11.10 5 145922 5549 29423051
Haematocrit decreased 13.88 11.10 85 145842 28937 29399663
Encephalomyelitis 13.88 11.10 6 145921 40 29428560
Viral load increased 13.85 11.10 31 145896 2018 29426582
Tooth infection 13.84 11.10 5 145922 5534 29423066
Infective aortitis 13.83 11.10 5 145922 19 29428581
Tuberculosis of genitourinary system 13.83 11.10 5 145922 19 29428581
Splenic peliosis 13.83 11.10 5 145922 19 29428581
Peritoneal candidiasis 13.83 11.10 5 145922 19 29428581
Acquired macroglossia 13.83 11.10 5 145922 19 29428581
Gastric varices 13.82 11.10 13 145914 375 29428225
Blood glucose decreased 13.75 11.10 24 145903 12045 29416555
Eosinophilic colitis 13.71 11.10 10 145917 200 29428400
Papule 13.69 11.10 41 145886 3188 29425412
Hospice care 13.68 11.10 4 145923 5064 29423536
Hypothyroidism 13.67 11.10 37 145890 15869 29412731
Jejunal perforation 13.66 11.10 10 145917 201 29428399
Pancreatitis acute 13.65 11.10 182 145745 24203 29404397
Oedematous kidney 13.63 11.10 5 145922 20 29428580
Myelodysplastic syndrome unclassifiable 13.63 11.10 5 145922 20 29428580
Phaeohyphomycotic brain abscess 13.63 11.10 6 145921 42 29428558
Large intestine perforation 13.62 11.10 72 145855 7284 29421316
Transplant 13.61 11.10 17 145910 680 29427920
Mental impairment 13.59 11.10 15 145912 9126 29419474
Molluscum contagiosum 13.59 11.10 11 145916 258 29428342
Septic embolus 13.57 11.10 21 145906 1029 29427571
Splenic haemorrhage 13.56 11.10 13 145914 384 29428216
Sudden death 13.55 11.10 31 145896 14079 29414521
Obsessive-compulsive disorder 13.53 11.10 3 145924 4573 29424027
Rectal prolapse 13.52 11.10 11 145916 260 29428340
Proteus infection 13.47 11.10 19 145908 856 29427744
Erythema multiforme 13.42 11.10 11 145916 7706 29420894
Failure to thrive 13.41 11.10 74 145853 7610 29420990
Uraemic encephalopathy 13.38 11.10 11 145916 264 29428336
Vena cava injury 13.37 11.10 10 145917 208 29428392
Narrow anterior chamber angle 13.36 11.10 8 145919 113 29428487
Intestinal ulcer 13.35 11.10 18 145909 777 29427823
Pharyngeal abscess 13.34 11.10 13 145914 392 29428208
Renal cyst haemorrhage 13.34 11.10 13 145914 392 29428208
Nephrocalcinosis 13.34 11.10 15 145912 536 29428064
Splenic necrosis 13.28 11.10 6 145921 45 29428555
Vascular pseudoaneurysm ruptured 13.28 11.10 7 145920 76 29428524
Rotator cuff syndrome 13.27 11.10 4 145923 4966 29423634
Type 3 diabetes mellitus 13.26 11.10 5 145922 22 29428578
St. Louis encephalitis 13.25 11.10 4 145923 7 29428593
Endocarditis viral 13.25 11.10 4 145923 7 29428593
Vestibular nystagmus 13.25 11.10 4 145923 7 29428593
Hypertrophic osteoarthropathy 13.20 11.10 7 145920 77 29428523
Colon dysplasia 13.12 11.10 8 145919 117 29428483
Biliary dilatation 13.11 11.10 17 145910 706 29427894
Crying 13.08 11.10 5 145922 5346 29423254
Necrotising fasciitis fungal 13.08 11.10 5 145922 23 29428577
Food interaction 13.06 11.10 19 145908 881 29427719
Disseminated varicella zoster vaccine virus infection 13.06 11.10 6 145921 47 29428553
Oral pain 13.06 11.10 16 145911 9291 29419309
Blood test abnormal 13.05 11.10 6 145921 5743 29422857
Ventricular extrasystoles 13.03 11.10 20 145907 10562 29418038
Migraine 13.02 11.10 26 145901 12404 29416196
Pneumonia legionella 12.99 11.10 26 145901 1565 29427035
Blood iron decreased 12.98 11.10 3 145924 4445 29424155
SARS-CoV-2 viraemia 12.95 11.10 3 145924 0 29428600
High grade B-cell lymphoma Burkitt-like lymphoma stage IV 12.95 11.10 3 145924 0 29428600
Aeromonas test positive 12.95 11.10 3 145924 0 29428600
Retroperitoneal effusion 12.95 11.10 3 145924 0 29428600
Pulmonary sensitisation 12.95 11.10 3 145924 0 29428600
Exserohilum infection 12.95 11.10 3 145924 0 29428600
Central nervous system viral infection 12.95 11.10 3 145924 0 29428600
Optic pathway injury 12.95 11.10 3 145924 0 29428600
Conjunctival neoplasm 12.95 11.10 3 145924 0 29428600
Small intestine transplant 12.95 11.10 3 145924 0 29428600
Bile duct cancer recurrent 12.95 11.10 3 145924 0 29428600
Incision site discharge 12.95 11.10 3 145924 0 29428600
Leukoencephalomyelitis 12.95 11.10 3 145924 0 29428600
Unresponsive to stimuli 12.86 11.10 72 145855 25054 29403546
Plasmablastic lymphoma 12.86 11.10 10 145917 221 29428379
Periodontitis 12.85 11.10 28 145899 1789 29426811
Cardiac failure chronic 12.84 11.10 8 145919 6459 29422141
Necrotising colitis 12.81 11.10 20 145907 988 29427612
Gingival bleeding 12.79 11.10 8 145919 6445 29422155
SARS-CoV-2 antibody test positive 12.78 11.10 10 145917 223 29428377
Acid fast bacilli infection 12.75 11.10 7 145920 83 29428517
Localised infection 12.75 11.10 31 145896 13785 29414815
Cardiac index increased 12.75 11.10 5 145922 25 29428575
Page kidney 12.74 11.10 6 145921 50 29428550
Splenic infection fungal 12.68 11.10 7 145920 84 29428516
Hyperoxaluria 12.66 11.10 8 145919 125 29428475
Myeloma cast nephropathy 12.64 11.10 6 145921 51 29428549
Precursor T-lymphoblastic lymphoma/leukaemia 12.64 11.10 6 145921 51 29428549
Malabsorption 12.64 11.10 29 145898 1919 29426681
Dialysis 12.61 11.10 90 145837 10118 29418482
Arm amputation 12.61 11.10 8 145919 126 29428474
Tropical spastic paresis 12.60 11.10 4 145923 9 29428591
Toothache 12.59 11.10 6 145921 5626 29422974
Peripheral T-cell lymphoma unspecified 12.56 11.10 13 145914 422 29428178
Joint stiffness 12.55 11.10 17 145910 9456 29419144
Therapeutic response shortened 12.54 11.10 4 145923 4787 29423813
Haemorrhagic pneumonia 12.50 11.10 8 145919 128 29428472
Alcohol abuse 12.49 11.10 3 145924 4330 29424270
Lower respiratory tract infection 12.47 11.10 78 145849 26424 29402176
Pneumonia herpes viral 12.46 11.10 7 145920 87 29428513
Ophthalmic herpes zoster 12.45 11.10 17 145910 743 29427857
Corneal endotheliitis 12.43 11.10 5 145922 27 29428573
Diffuse mesangial sclerosis 12.43 11.10 5 145922 27 29428573
Pneumonia staphylococcal 12.41 11.10 36 145891 2749 29425851
Mood altered 12.41 11.10 13 145914 8098 29420502
Extrapulmonary tuberculosis 12.39 11.10 7 145920 88 29428512
Ischaemic stroke 12.39 11.10 39 145888 15938 29412662
Respiratory distress 12.38 11.10 225 145702 31881 29396719
Gene mutation 12.32 11.10 20 145907 1021 29427579
Tonsillar neoplasm 12.30 11.10 4 145923 10 29428590
Abdominal rebound tenderness 12.30 11.10 4 145923 10 29428590
Asymptomatic viral hepatitis 12.29 11.10 5 145922 28 29428572
Disseminated blastomycosis 12.26 11.10 7 145920 90 29428510
Illness 12.26 11.10 9 145918 6665 29421935
Hepatitis B surface antigen positive 12.23 11.10 8 145919 133 29428467
Pancreatitis 12.23 11.10 110 145817 34404 29394196
Circulatory collapse 12.20 11.10 49 145878 18624 29409976
Gastrointestinal fungal infection 12.19 11.10 7 145920 91 29428509
Vaccination failure 12.19 11.10 14 145913 512 29428088
Hyperamylasaemia 12.15 11.10 14 145913 514 29428086
Fungal peritonitis 12.13 11.10 16 145911 676 29427924
Clostridial infection 12.13 11.10 40 145887 3275 29425325
Laryngeal cancer 12.11 11.10 16 145911 677 29427923
Nosocomial infection 12.08 11.10 20 145907 1038 29427562
Vesical fistula 12.07 11.10 6 145921 57 29428543
Exercise tolerance decreased 12.06 11.10 3 145924 4228 29424372
Arteritis 12.05 11.10 11 145916 305 29428295
Parvimonas micra infection 12.03 11.10 4 145923 11 29428589
Oesophageal tuberculosis 12.03 11.10 4 145923 11 29428589
Bradyphrenia 11.99 11.10 3 145924 4211 29424389
Cat scratch disease 11.93 11.10 7 145920 95 29428505
Viral mutation identified 11.91 11.10 33 145894 2455 29426145
Leukaemia recurrent 11.89 11.10 24 145903 1453 29427147
Haemosiderosis 11.88 11.10 9 145918 191 29428409
Infertility 11.88 11.10 9 145918 191 29428409
Wound infection pseudomonas 11.85 11.10 10 145917 249 29428351
Arterial rupture 11.84 11.10 13 145914 452 29428148
Granulomatous rosacea 11.83 11.10 8 145919 141 29428459
Ankylosing spondylitis 11.83 11.10 3 145924 4173 29424427
Chronic graft versus host disease oral 11.81 11.10 6 145921 60 29428540
Sinus congestion 11.80 11.10 4 145923 4608 29423992
T-lymphocyte count abnormal 11.78 11.10 4 145923 12 29428588
Rash maculo-papular 11.68 11.10 71 145856 24218 29404382
Leukoencephalopathy 11.66 11.10 43 145884 3724 29424876
Giardiasis 11.65 11.10 10 145917 255 29428345
Colitis ulcerative 11.64 11.10 105 145822 12664 29415936
Enterocolitis viral 11.64 11.10 6 145921 62 29428538
Cardiac autonomic neuropathy 11.64 11.10 6 145921 62 29428538
Wound evisceration 11.62 11.10 7 145920 100 29428500
Removal of renal transplant 11.61 11.10 5 145922 33 29428567
Thirst 11.61 11.10 9 145918 6482 29422118
Obstructive airways disorder 11.58 11.10 23 145904 10993 29417607
Bowen's disease 11.55 11.10 8 145919 147 29428453
Splenic neoplasm malignancy unspecified 11.54 11.10 4 145923 13 29428587
Superinfection viral 11.54 11.10 4 145923 13 29428587
Cardiomyopathy 11.54 11.10 36 145891 14751 29413849
Porphyria acute 11.53 11.10 9 145918 200 29428400
Bone marrow failure 11.52 11.10 195 145732 27254 29401346
Incoherent 11.47 11.10 3 145924 4089 29424511
Pupillary reflex impaired 11.47 11.10 23 145904 1386 29427214
Genital herpes 11.46 11.10 14 145913 547 29428053
Blood pressure abnormal 11.42 11.10 10 145917 6780 29421820
Gallbladder disorder 11.39 11.10 7 145920 5693 29422907
Vascular graft complication 11.38 11.10 7 145920 104 29428496
Pseudopolyp 11.38 11.10 9 145918 204 29428396
Cutaneous leishmaniasis 11.38 11.10 9 145918 204 29428396
Renal necrosis 11.36 11.10 8 145919 151 29428449
Lung squamous cell carcinoma stage IV 11.36 11.10 5 145922 35 29428565
T-cell lymphoma recurrent 11.36 11.10 5 145922 35 29428565
Coordination abnormal 11.34 11.10 11 145916 7103 29421497
Toxic encephalopathy 11.34 11.10 49 145878 4563 29424037
Prescribed underdose 11.33 11.10 13 145914 7773 29420827
Fracture 11.33 11.10 8 145919 6045 29422555
Urinary tract inflammation 11.32 11.10 4 145923 14 29428586
Gonococcal infection 11.24 11.10 5 145922 36 29428564
Cerebral ventricle collapse 11.24 11.10 6 145921 67 29428533
Bundle branch block left 11.23 11.10 6 145921 5271 29423329
Muscle spasticity 11.23 11.10 5 145922 4878 29423722
Blindness cortical 11.23 11.10 11 145916 334 29428266
Optic discs blurred 11.16 11.10 6 145921 68 29428532
Foot deformity 11.15 11.10 3 145924 4012 29424588
Respiratory tract congestion 11.13 11.10 6 145921 5243 29423357
Mean cell haemoglobin concentration 11.12 11.10 5 145922 37 29428563
Pleuropericarditis 11.12 11.10 9 145918 211 29428389
Hypoalbuminaemia 11.12 11.10 88 145839 10217 29418383
Anti-GAD antibody positive 11.11 11.10 4 145923 15 29428585

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Transplant rejection 5449.02 10.42 2140 234493 15261 64246838
Cytomegalovirus infection 4111.92 10.42 2218 234415 34981 64227118
Post transplant lymphoproliferative disorder 3491.43 10.42 1315 235318 8229 64253870
Thrombotic microangiopathy 2559.82 10.42 1241 235392 15414 64246685
Immunosuppressant drug level increased 2377.85 10.42 923 235710 6336 64255763
Polyomavirus-associated nephropathy 2368.36 10.42 829 235804 4059 64258040
Kidney transplant rejection 2255.42 10.42 959 235674 8552 64253547
Product use in unapproved indication 2172.95 10.42 2945 233688 173673 64088426
Transplant dysfunction 1763.49 10.42 728 235905 5980 64256119
BK virus infection 1719.78 10.42 736 235897 6676 64255423
Complications of transplanted kidney 1677.49 10.42 662 235971 4773 64257326
Cytomegalovirus viraemia 1616.04 10.42 791 235842 10037 64252062
Acute graft versus host disease 1526.79 10.42 720 235913 8364 64253735
Epstein-Barr virus infection 1492.20 10.42 785 235848 11703 64250396
Graft versus host disease 1437.12 10.42 792 235841 13021 64249078
Liver transplant rejection 1385.46 10.42 491 236142 2508 64259591
COVID-19 1318.57 10.42 1401 235232 63739 64198360
Nocardiosis 1265.39 10.42 521 236112 4246 64257853
Aspergillus infection 1106.73 10.42 711 235922 15668 64246431
Drug level increased 1069.86 10.42 935 235698 33261 64228838
Posterior reversible encephalopathy syndrome 1052.87 10.42 785 235848 22161 64239938
Chronic graft versus host disease 1031.81 10.42 490 236143 5786 64256313
Fatigue 1009.79 10.42 767 235866 747963 63514136
Nephropathy toxic 870.85 10.42 629 236004 16885 64245214
Mucormycosis 867.08 10.42 458 236175 6883 64255216
Renal impairment 848.11 10.42 1662 234971 133355 64128744
Adenovirus infection 846.63 10.42 449 236184 6806 64255293
Off label use 828.80 10.42 4528 232105 628278 63633821
Bronchopulmonary aspergillosis 794.13 10.42 616 236017 18469 64243630
Phaeohyphomycosis 779.18 10.42 247 236386 827 64261272
Multiple organ dysfunction syndrome 769.14 10.42 1354 235279 100059 64162040
Fall 763.69 10.42 288 236345 416538 63845561
Transplant failure 757.47 10.42 339 236294 3455 64258644
Acute graft versus host disease in skin 757.11 10.42 409 236224 6446 64255653
Completed suicide 712.32 10.42 25 236608 224389 64037710
Delayed graft function 709.23 10.42 303 236330 2733 64259366
Drug interaction 707.26 10.42 2912 233721 359171 63902928
Dizziness 702.74 10.42 351 236282 429812 63832287
Immunosuppressant drug level decreased 692.30 10.42 258 236375 1557 64260542
Arthralgia 662.81 10.42 402 236231 441858 63820241
Pain 661.66 10.42 635 235998 552876 63709223
Pneumocystis jirovecii pneumonia 650.48 10.42 645 235988 26989 64235110
Dyspnoea 636.47 10.42 1038 235595 717636 63544463
Enterococcal infection 635.17 10.42 474 236159 13392 64248707
Klebsiella infection 633.06 10.42 465 236168 12816 64249283
Chronic allograft nephropathy 627.30 10.42 229 236404 1292 64260807
Renal transplant failure 599.59 10.42 226 236407 1414 64260685
Nausea 594.89 10.42 1249 235384 784551 63477548
Parvovirus B19 infection 588.07 10.42 207 236426 1032 64261067
Graft versus host disease in skin 579.30 10.42 315 236318 5032 64257067
Focal segmental glomerulosclerosis 555.83 10.42 253 236380 2691 64259408
Diffuse large B-cell lymphoma 551.63 10.42 388 236245 9973 64252126
Strongyloidiasis 544.11 10.42 253 236380 2837 64259262
Pseudomonas infection 527.32 10.42 473 236160 17410 64244689
Drug hypersensitivity 523.65 10.42 116 236517 237699 64024400
Cytomegalovirus infection reactivation 522.70 10.42 302 236331 5454 64256645
Epstein-Barr virus associated lymphoproliferative disorder 517.21 10.42 245 236388 2874 64259225
Septic shock 511.95 10.42 1169 235464 104268 64157831
Haemophagocytic lymphohistiocytosis 511.83 10.42 462 236171 17147 64244952
Joint swelling 510.08 10.42 88 236545 215294 64046805
Graft versus host disease in gastrointestinal tract 508.44 10.42 294 236339 5318 64256781
Epstein-Barr viraemia 495.98 10.42 202 236431 1595 64260504
Trichodysplasia spinulosa 491.97 10.42 158 236475 558 64261541
Kidney fibrosis 485.04 10.42 234 236399 2867 64259232
Cryptococcosis 474.05 10.42 222 236411 2533 64259566
Leukopenia 473.37 10.42 1106 235527 100136 64161963
Escherichia infection 464.73 10.42 410 236223 14758 64247341
Acute kidney injury 463.51 10.42 3024 233609 446216 63815883
Drug abuse 453.78 10.42 6 236627 132368 64129731
Blood creatinine increased 451.31 10.42 1305 235328 134477 64127622
JC virus infection 444.12 10.42 226 236407 3129 64258970
Graft loss 442.91 10.42 159 236474 848 64261251
Hepatitis E 427.92 10.42 199 236434 2232 64259867
Peripheral swelling 418.21 10.42 124 236509 209029 64053070
Rash 416.47 10.42 650 235983 457899 63804200
Polyomavirus viraemia 413.49 10.42 157 236476 1005 64261094
Cytomegalovirus test positive 412.34 10.42 249 236384 4895 64257204
Pain in extremity 411.21 10.42 307 236326 302778 63959321
Malaise 404.11 10.42 517 236116 395730 63866369
Hypersensitivity 397.30 10.42 114 236519 196338 64065761
Post transplant distal limb syndrome 393.23 10.42 124 236509 406 64261693
Respiratory failure 384.68 10.42 1383 235250 159800 64102299
Brain abscess 378.67 10.42 219 236414 3962 64258137
Hepatitis C 378.59 10.42 318 236315 10697 64251402
Human polyomavirus infection 378.25 10.42 142 236491 877 64261222
Renal tubular necrosis 376.94 10.42 435 236198 21675 64240424
Asthenia 373.32 10.42 623 236010 427421 63834678
Cystitis haemorrhagic 368.89 10.42 274 236359 7682 64254417
Infusion related reaction 368.46 10.42 77 236556 164390 64097709
Renal tubular atrophy 368.42 10.42 156 236477 1373 64260726
Acute graft versus host disease in intestine 367.22 10.42 204 236429 3405 64258694
Heart transplant rejection 366.63 10.42 148 236485 1139 64260960
Arthropathy 362.19 10.42 20 236613 120947 64141152
Varicella zoster virus infection 361.06 10.42 207 236426 3681 64258418
Lung transplant rejection 354.90 10.42 146 236487 1186 64260913
Smooth muscle cell neoplasm 352.00 10.42 129 236504 737 64261362
Ovarian cyst 351.95 10.42 305 236328 10713 64251386
Pneumonia cytomegaloviral 347.71 10.42 210 236423 4129 64257970
Aplasia pure red cell 346.54 10.42 251 236382 6763 64255336
Haemolytic uraemic syndrome 344.06 10.42 203 236430 3818 64258281
Lymphoproliferative disorder 331.05 10.42 216 236417 4887 64257212
Viraemia 330.77 10.42 165 236468 2184 64259915
Cytomegalovirus colitis 327.46 10.42 195 236438 3733 64258366
Contraindicated product administered 319.22 10.42 19 236614 107810 64154289
Anxiety 318.93 10.42 173 236460 202476 64059623
Constipation 312.58 10.42 231 236402 229106 64032993
Meningitis cryptococcal 311.41 10.42 172 236461 2837 64259262
Headache 307.24 10.42 961 235672 528506 63733593
Pruritus 305.62 10.42 420 236213 311980 63950119
Back pain 303.90 10.42 282 236351 249889 64012210
Cryptosporidiosis infection 302.89 10.42 107 236526 540 64261559
Pulmonary nocardiosis 300.89 10.42 111 236522 648 64261451
Candida infection 297.70 10.42 464 236169 30955 64231144
Toxoplasmosis 295.75 10.42 155 236478 2289 64259810
Human herpesvirus 8 infection 294.03 10.42 120 236513 953 64261146
Scedosporium infection 292.40 10.42 125 236508 1129 64260970
Diabetes mellitus 290.90 10.42 708 235925 65766 64196333
Lymphocele 287.81 10.42 134 236499 1507 64260592
Venoocclusive liver disease 283.64 10.42 259 236374 9756 64252343
Injection site pain 283.15 10.42 37 236596 111371 64150728
Product dose omission issue 282.83 10.42 183 236450 194564 64067535
Infection reactivation 278.21 10.42 140 236493 1890 64260209
Syncope 278.04 10.42 115 236518 157520 64104579
Chronic graft versus host disease in skin 276.74 10.42 124 236509 1267 64260832
Synovitis 274.56 10.42 24 236609 99066 64163033
Histoplasmosis disseminated 274.43 10.42 138 236495 1860 64260239
Somnolence 271.23 10.42 210 236423 203435 64058664
Human herpesvirus 6 infection 270.57 10.42 184 236449 4470 64257629
Pneumatosis intestinalis 269.50 10.42 192 236441 5037 64257062
Proteinuria 269.06 10.42 414 236219 27309 64234790
Acute respiratory distress syndrome 268.29 10.42 499 236134 38436 64223663
Nasopharyngitis 267.79 10.42 197 236436 195876 64066223
Feeling abnormal 267.32 10.42 79 236554 133523 64128576
Alternaria infection 266.75 10.42 95 236538 493 64261606
Abdominal discomfort 263.83 10.42 172 236461 182150 64079949
Actinic keratosis 260.12 10.42 187 236446 4978 64257121
Mycobacterial infection 256.05 10.42 151 236482 2837 64259262
Progressive multifocal leukoencephalopathy 255.79 10.42 325 236308 17907 64244192
Pathogen resistance 255.63 10.42 271 236362 12272 64249827
Disease recurrence 250.67 10.42 430 236203 31080 64231019
Swelling 250.25 10.42 138 236495 160080 64102019
Neurotoxicity 248.96 10.42 397 236236 27007 64235092
West Nile viral infection 245.98 10.42 101 236532 816 64261283
Depression 244.08 10.42 189 236444 183102 64078997
Therapeutic product effect decreased 242.39 10.42 62 236571 115289 64146810
Tubulointerstitial nephritis 242.21 10.42 419 236214 30490 64231609
Sepsis 240.62 10.42 1557 235076 228784 64033315
Pancytopenia 237.01 10.42 1098 235535 142211 64119888
Transplantation associated food allergy 234.34 10.42 56 236577 30 64262069
Squamous cell carcinoma 231.59 10.42 270 236363 13599 64248500
Malacoplakia 230.59 10.42 69 236564 179 64261920
Hypotension 229.59 10.42 679 235954 380295 63881804
Dermatophytosis 228.29 10.42 77 236556 329 64261770
Intentional overdose 228.24 10.42 30 236603 89914 64172185
Histoplasmosis 227.05 10.42 122 236511 1900 64260199
Contusion 223.26 10.42 70 236563 113895 64148204
Weight increased 222.73 10.42 273 236360 213075 64049024
Systemic mycosis 221.94 10.42 126 236507 2197 64259902
Complications of transplanted liver 220.63 10.42 73 236560 290 64261809
Fungal infection 219.94 10.42 426 236207 33825 64228274
Renal graft infection 219.17 10.42 75 236558 338 64261761
Staphylococcal infection 217.69 10.42 536 236097 50142 64211957
Mycobacterium abscessus infection 216.55 10.42 95 236538 919 64261180
Epstein-Barr virus infection reactivation 216.32 10.42 99 236534 1067 64261032
Fungal skin infection 214.40 10.42 166 236467 4959 64257140
Chest pain 212.33 10.42 336 236297 235644 64026455
Myocardial infarction 209.55 10.42 180 236453 165641 64096458
Sinusitis 206.59 10.42 141 236492 145787 64116312
Acne 206.41 10.42 332 236301 22749 64239350
Death 205.91 10.42 991 235642 481714 63780385
Musculoskeletal stiffness 204.47 10.42 98 236535 123108 64138991
Squamous cell carcinoma of skin 202.99 10.42 234 236399 11642 64250457
Urticaria 202.41 10.42 147 236486 147170 64114929
Glossodynia 202.35 10.42 8 236625 64688 64197411
Insomnia 199.36 10.42 260 236373 197576 64064523
COVID-19 pneumonia 198.78 10.42 273 236360 16231 64245868
Hyperhidrosis 195.91 10.42 107 236526 124813 64137286
Pancreas transplant rejection 195.90 10.42 64 236569 242 64261857
Pemphigus 195.12 10.42 6 236627 60695 64201404
Renal tubular injury 194.96 10.42 92 236541 1069 64261030
Chronic obstructive pulmonary disease 194.67 10.42 18 236615 71030 64191069
Drug resistance 193.74 10.42 410 236223 34692 64227407
Drug level fluctuating 190.80 10.42 77 236556 592 64261507
Bacteraemia 190.54 10.42 349 236284 26562 64235537
Acute graft versus host disease in liver 190.03 10.42 102 236531 1585 64260514
Pyelonephritis 189.26 10.42 273 236360 16993 64245106
Vomiting 189.00 10.42 1216 235417 549901 63712198
Drug level decreased 188.84 10.42 222 236411 11281 64250818
Malignant neoplasm progression 188.49 10.42 89 236544 112782 64149317
Premature delivery 188.01 10.42 283 236350 18306 64243793
Muscle spasms 183.19 10.42 149 236484 140874 64121225
Blastomycosis 180.31 10.42 68 236565 426 64261673
Blood pressure increased 176.70 10.42 224 236409 172328 64089771
Hepatic artery thrombosis 176.45 10.42 59 236574 244 64261855
Injection site erythema 176.35 10.42 25 236608 70775 64191324
Obliterative bronchiolitis 175.80 10.42 114 236519 2551 64259548
Cytomegalovirus enteritis 175.15 10.42 73 236560 615 64261484
Stenotrophomonas infection 174.85 10.42 120 236513 2960 64259139
Gastroenteritis norovirus 174.01 10.42 115 236518 2660 64259439
Trichophytosis 173.83 10.42 60 236573 279 64261820
Complications of transplant surgery 173.42 10.42 74 236559 665 64261434
Malacoplakia gastrointestinal 171.91 10.42 51 236582 127 64261972
Neutrophil Pelger-Huet anomaly present 171.45 10.42 60 236573 293 64261806
Rhodococcus infection 171.30 10.42 55 236578 194 64261905
Mobility decreased 171.23 10.42 51 236582 85789 64176310
Wound 170.79 10.42 36 236597 76441 64185658
Herpes simplex 170.74 10.42 202 236431 10334 64251765
Pulmonary mucormycosis 169.93 10.42 75 236558 737 64261362
Hypoaesthesia 169.73 10.42 156 236477 138952 64123147
Disseminated cryptococcosis 168.86 10.42 92 236541 1475 64260624
Chest discomfort 167.25 10.42 110 236523 115996 64146103
Balance disorder 165.35 10.42 51 236582 83875 64178224
Asthma 162.23 10.42 73 236560 95152 64166947
Cerebrovascular accident 160.04 10.42 161 236472 137422 64124677
Graft versus host disease in lung 157.81 10.42 71 236562 733 64261366
Angiosarcoma 157.20 10.42 59 236574 364 64261735
Ureaplasma infection 157.14 10.42 69 236564 669 64261430
Gait disturbance 156.81 10.42 243 236390 171912 64090187
Acinetobacter infection 155.57 10.42 102 236531 2327 64259772
Complications of transplanted lung 155.06 10.42 58 236575 354 64261745
Renal failure 153.67 10.42 1167 235466 180521 64081578
Suicidal ideation 153.45 10.42 29 236604 66513 64195586
Enterobacter infection 153.05 10.42 119 236514 3577 64258522
Renal transplant 152.82 10.42 98 236535 2150 64259949
Rheumatoid arthritis 152.43 10.42 229 236404 164065 64098034
Pneumonia fungal 151.87 10.42 175 236458 8702 64253397
Osmotic demyelination syndrome 151.61 10.42 79 236554 1152 64260947
Anogenital warts 150.82 10.42 69 236564 743 64261356
Encephalitis viral 150.14 10.42 99 236534 2281 64259818
Heart rate increased 149.71 10.42 88 236545 98587 64163512
Viral haemorrhagic cystitis 149.02 10.42 86 236547 1549 64260550
Decreased appetite 147.35 10.42 533 236100 280756 63981343
Cardiac failure congestive 146.03 10.42 158 236475 130422 64131677
Renal tubular acidosis 145.78 10.42 106 236527 2873 64259226
Biliary anastomosis complication 145.73 10.42 44 236589 119 64261980
Encephalitis 144.01 10.42 203 236430 12368 64249731
Immune reconstitution inflammatory syndrome 143.79 10.42 202 236431 12268 64249831
Alveolar proteinosis 142.49 10.42 60 236573 520 64261579
Skin papilloma 142.36 10.42 132 236501 5071 64257028
Loss of consciousness 142.33 10.42 202 236431 148163 64113936
Bradycardia 140.18 10.42 136 236497 118083 64144016
Wheezing 140.06 10.42 60 236573 80519 64181580
Systemic candida 139.67 10.42 132 236501 5197 64256902
End stage renal disease 139.51 10.42 182 236451 10293 64251806
Complications of transplanted heart 139.22 10.42 50 236583 267 64261832
Hypogammaglobulinaemia 138.82 10.42 180 236453 10119 64251980
Hydronephrosis 138.54 10.42 212 236421 13913 64248186
Cerebral aspergillosis 138.40 10.42 83 236550 1610 64260489
Discomfort 137.77 10.42 62 236571 80816 64181283
Drug reaction with eosinophilia and systemic symptoms 137.74 10.42 18 236615 54199 64207900
Flushing 137.60 10.42 58 236575 78590 64183509
Nephrotic syndrome 134.91 10.42 171 236462 9396 64252703
Suicide attempt 134.84 10.42 46 236587 70961 64191138
Epidermodysplasia verruciformis 134.73 10.42 43 236590 148 64261951
Paraesthesia 134.22 10.42 178 236455 134344 64127755
Glomerulonephritis 133.86 10.42 100 236533 2828 64259271
Polyomavirus test positive 133.74 10.42 44 236589 171 64261928
Drug intolerance 133.72 10.42 308 236325 187684 64074415
Heart rate decreased 133.56 10.42 21 236612 55046 64207053
Ureteric stenosis 132.75 10.42 73 236560 1193 64260906
Palpitations 132.47 10.42 113 236520 104375 64157724
Oxygen saturation decreased 132.14 10.42 119 236514 107057 64155042
Acute myeloid leukaemia recurrent 131.57 10.42 97 236536 2687 64259412
Injection site reaction 130.06 10.42 11 236622 46653 64215446
IgA nephropathy 129.56 10.42 75 236558 1359 64260740
Cytomegalovirus gastrointestinal infection 128.38 10.42 52 236581 404 64261695
Organising pneumonia 126.35 10.42 161 236472 8894 64253205
Bacterial sepsis 125.88 10.42 146 236487 7311 64254788
Papilloma viral infection 125.49 10.42 74 236559 1390 64260709
Cerebral toxoplasmosis 125.11 10.42 80 236553 1746 64260353
Glomerulosclerosis 124.81 10.42 64 236569 901 64261198
Kaposi's sarcoma 124.69 10.42 59 236574 690 64261409
Cholangitis 124.58 10.42 175 236458 10627 64251472
Renal artery stenosis 123.83 10.42 96 236537 2873 64259226
Lymphopenia 123.83 10.42 284 236349 25373 64236726
Donor specific antibody present 122.08 10.42 42 236591 193 64261906
Wrong technique in product usage process 121.81 10.42 43 236590 64931 64197168
Therapeutic product effect incomplete 121.59 10.42 120 236513 103362 64158737
Epistaxis 120.92 10.42 109 236524 98022 64164077
Ascites 120.64 10.42 499 236134 61502 64200597
Pneumonia cryptococcal 120.52 10.42 68 236565 1171 64260928
Cytomegalovirus chorioretinitis 119.91 10.42 117 236516 4795 64257304
Graft versus host disease in liver 119.41 10.42 73 236560 1468 64260631
Memory impairment 118.29 10.42 85 236548 85597 64176502
Confusional state 118.28 10.42 524 236109 260620 64001479
Chronic graft versus host disease in liver 117.11 10.42 52 236581 519 64261580
Post procedural bile leak 116.94 10.42 46 236587 328 64261771
Adenoviral haemorrhagic cystitis 116.06 10.42 50 236583 461 64261638
Coronavirus infection 115.38 10.42 121 236512 5409 64256690
Acanthamoeba infection 115.15 10.42 49 236584 437 64261662
Cytomegalovirus enterocolitis 114.86 10.42 68 236565 1287 64260812
Arthritis 114.60 10.42 84 236549 83730 64178369
Mycobacterium avium complex infection 113.73 10.42 103 236530 3837 64258262
Haemolytic anaemia 113.39 10.42 208 236425 15845 64246254
Abdominal pain upper 113.33 10.42 301 236332 174729 64087370
New onset diabetes after transplantation 113.27 10.42 35 236598 105 64261994
Liver abscess 112.80 10.42 117 236516 5163 64256936
Erythema 112.04 10.42 334 236299 186736 64075363
Cytomegalovirus gastritis 111.67 10.42 46 236587 375 64261724
Pneumonia klebsiella 111.58 10.42 103 236530 3934 64258165
American trypanosomiasis 111.22 10.42 43 236590 291 64261808
Glomerulonephritis membranoproliferative 111.15 10.42 49 236584 480 64261619
Hypoglycaemia 110.58 10.42 100 236533 89792 64172307
Escherichia bacteraemia 110.56 10.42 117 236516 5286 64256813
Haemodialysis 110.35 10.42 213 236420 16864 64245235
Myalgia 110.27 10.42 263 236370 158354 64103745
Infective aneurysm 110.01 10.42 57 236576 821 64261278
Dry mouth 109.86 10.42 42 236591 60376 64201723
Fibromyalgia 109.79 10.42 5 236628 35726 64226373
Systemic lupus erythematosus 109.78 10.42 75 236558 77537 64184562
Endophthalmitis 109.47 10.42 116 236517 5249 64256850
Musculoskeletal pain 109.18 10.42 83 236550 81211 64180888
Lung transplant 108.13 10.42 102 236531 4006 64258093
Injection site swelling 106.82 10.42 13 236620 41340 64220759
Disseminated mucormycosis 106.56 10.42 47 236586 461 64261638
Bacterial pyelonephritis 106.23 10.42 48 236585 501 64261598
Inappropriate schedule of product administration 106.15 10.42 109 236524 92177 64169922
Mycoplasma infection 106.12 10.42 51 236582 619 64261480
Epstein-Barr virus test positive 105.90 10.42 58 236575 940 64261159
Osteoarthritis 105.62 10.42 50 236583 63286 64198813
Urinary tract infection bacterial 104.98 10.42 111 236522 5010 64257089
Nephropathy 104.44 10.42 141 236492 8245 64253854
Cough 104.13 10.42 665 235968 301483 63960616
Escherichia urinary tract infection 103.35 10.42 170 236463 11867 64250232
Bile duct stenosis 102.44 10.42 70 236563 1714 64260385
Pneumocystis jirovecii infection 102.10 10.42 78 236555 2283 64259816
Lower respiratory tract infection 101.91 10.42 118 236515 94496 64167603
Pneumonia pseudomonal 101.80 10.42 107 236526 4796 64257303
Encapsulating peritoneal sclerosis 101.76 10.42 53 236580 772 64261327
Drug ineffective for unapproved indication 101.10 10.42 297 236336 30836 64231263
Irritable bowel syndrome 100.95 10.42 10 236623 37359 64224740
Bacterial infection 100.94 10.42 258 236375 24692 64237407
Encephalopathy 100.33 10.42 455 236178 58364 64203735
Engraftment syndrome 99.99 10.42 58 236575 1055 64261044
Hypokalaemia 99.08 10.42 185 236448 121718 64140381
Liver transplant 99.01 10.42 97 236536 3995 64258104
Human ehrlichiosis 98.51 10.42 41 236592 344 64261755
Blister 98.48 10.42 91 236542 80876 64181223
Infection in an immunocompromised host 98.40 10.42 56 236577 981 64261118
Intestine transplant rejection 98.24 10.42 28 236605 57 64262042
Graft complication 98.07 10.42 48 236585 608 64261491
Disseminated intravascular coagulation 97.89 10.42 301 236332 32047 64230052
Blood pressure fluctuation 97.80 10.42 34 236599 51837 64210262
Human herpesvirus 6 encephalitis 97.79 10.42 42 236591 384 64261715
Periostitis 97.76 10.42 45 236588 492 64261607
Pneumomediastinum 96.11 10.42 82 236551 2818 64259281
Neck pain 96.01 10.42 53 236580 61480 64200619
Choroiditis 95.95 10.42 56 236577 1031 64261068
Sedation 95.74 10.42 18 236615 41444 64220655
Atypical haemolytic uraemic syndrome 95.64 10.42 48 236585 644 64261455
Dysgeusia 95.56 10.42 27 236606 47020 64215079
Oropharyngeal pain 95.53 10.42 111 236522 88756 64173343
Chronic myeloid leukaemia 95.04 10.42 87 236546 3287 64258812
Pneumoperitoneum 94.67 10.42 79 236554 2632 64259467
Duodenal ulcer perforation 94.24 10.42 9 236624 34616 64227483
Rectal haemorrhage 93.94 10.42 55 236578 61762 64200337
Meningoencephalitis herpetic 93.85 10.42 66 236567 1695 64260404
Opportunistic infection 93.84 10.42 78 236555 2584 64259515
Autoimmune haemolytic anaemia 92.77 10.42 122 236511 6954 64255145
Injection site bruising 92.57 10.42 12 236621 36361 64225738
Cytomegalovirus oesophagitis 92.29 10.42 45 236588 565 64261534
Chronic kidney disease 91.41 10.42 438 236195 57481 64204618
Injection site pruritus 90.44 10.42 15 236618 37811 64224288
General physical health deterioration 90.24 10.42 414 236219 204011 64058088
Bacillary angiomatosis 90.02 10.42 32 236601 165 64261934
Cytomegalovirus nephritis 89.73 10.42 30 236603 124 64261975
Psoriatic arthropathy 89.48 10.42 24 236609 43257 64218842
Pain in jaw 89.32 10.42 20 236613 40735 64221364
Injury 89.16 10.42 47 236586 55945 64206154
Pericarditis 88.96 10.42 60 236573 62456 64199643
Neuropathy peripheral 88.92 10.42 186 236447 117339 64144760
Central nervous system lymphoma 88.27 10.42 66 236567 1869 64260230
Gastrooesophageal reflux disease 88.14 10.42 105 236528 83038 64179061
Dermoid cyst 87.87 10.42 35 236598 259 64261840
Hot flush 87.70 10.42 30 236603 46205 64215894
Stress 87.62 10.42 57 236576 60477 64201622
Liver transplant failure 87.15 10.42 28 236605 99 64262000
International normalised ratio increased 87.15 10.42 97 236536 79070 64183029
Microsporidia infection 87.13 10.42 47 236586 738 64261361
Osteomyelitis fungal 86.61 10.42 34 236599 241 64261858
Pyelonephritis acute 85.79 10.42 100 236533 5034 64257065
Orf 85.16 10.42 24 236609 46 64262053
Bronchitis 84.91 10.42 169 236464 108574 64153525
Cardio-respiratory arrest 84.75 10.42 144 236489 98249 64163850
Hepatic failure 84.61 10.42 415 236218 54979 64207120
Hepatic fibrosis 84.32 10.42 103 236530 5449 64256650
Necrotising oesophagitis 84.17 10.42 44 236589 646 64261453
Encephalitis cytomegalovirus 84.05 10.42 50 236583 955 64261144
Nasal congestion 83.90 10.42 58 236575 59600 64202499
Cytomegalovirus hepatitis 83.59 10.42 42 236591 565 64261534
Optic neuropathy 83.56 10.42 77 236556 2934 64259165
Steroid diabetes 83.52 10.42 73 236560 2593 64259506
Intentional self-injury 83.32 10.42 6 236627 29038 64233061
Eczema herpeticum 83.18 10.42 31 236602 187 64261912
Chronic hepatitis 83.05 10.42 54 236579 1214 64260885
Rhabdomyolysis 82.97 10.42 130 236503 91596 64170503
Passenger lymphocyte syndrome 82.43 10.42 25 236608 69 64262030
Clostridium difficile colitis 82.08 10.42 253 236380 26970 64235129
Helicobacter infection 81.75 10.42 20 236613 38342 64223757
Guillain-Barre syndrome 81.16 10.42 119 236514 7516 64254583
Staphylococcal bacteraemia 80.62 10.42 140 236493 10215 64251884
Emphysematous pyelonephritis 80.41 10.42 31 236602 208 64261891
Dyspepsia 80.36 10.42 106 236527 80206 64181893
Drug level above therapeutic 79.88 10.42 112 236521 6789 64255310
Diaphragmatic hernia 79.63 10.42 34 236599 306 64261793
Unevaluable event 79.48 10.42 43 236590 50446 64211653
Orthostatic hypotension 79.32 10.42 36 236597 46702 64215397
Sleep disorder 78.86 10.42 62 236571 59647 64202452
Swelling face 78.69 10.42 61 236572 59105 64202994
Adenoviral hepatitis 78.32 10.42 37 236596 431 64261668
Cytomegalovirus gastroenteritis 78.26 10.42 36 236597 393 64261706
Atrial fibrillation 78.19 10.42 342 236291 170747 64091352
Oedema peripheral 78.10 10.42 452 236181 209865 64052234
Feeling hot 77.76 10.42 35 236598 45628 64216471
Tremor 77.72 10.42 859 235774 147371 64114728
BK polyomavirus test positive 77.67 10.42 24 236609 72 64262027
Large intestinal ulcer 77.41 10.42 86 236547 4107 64257992
Cytomegalovirus syndrome 77.14 10.42 32 236601 266 64261833
Philadelphia positive chronic myeloid leukaemia 77.10 10.42 26 236607 111 64261988
Blood creatine phosphokinase increased 77.09 10.42 61 236572 58497 64203602
Pulmonary embolism 76.75 10.42 277 236356 146079 64116020
Chronic hepatitis C 76.03 10.42 38 236595 505 64261594
Venoocclusive disease 75.75 10.42 83 236550 3902 64258197
Fungal endocarditis 75.71 10.42 37 236596 467 64261632
Graft thrombosis 75.53 10.42 35 236598 389 64261710
Blood potassium decreased 75.27 10.42 27 236606 40372 64221727
Corynebacterium infection 75.16 10.42 46 236587 927 64261172
Agitation 74.57 10.42 131 236502 88236 64173863
Gastroenteritis sapovirus 74.45 10.42 26 236607 126 64261973
Erythema infectiosum 74.43 10.42 28 236605 174 64261925
Pneumonia bacterial 74.29 10.42 168 236465 14867 64247232
Adverse event 74.25 10.42 26 236607 39463 64222636
Bone pain 74.18 10.42 41 236592 47531 64214568
Gingival hypertrophy 73.82 10.42 69 236564 2678 64259421
Knee arthroplasty 73.52 10.42 7 236626 26992 64235107
Cutaneous malacoplakia 73.27 10.42 22 236611 58 64262041
Migraine 73.24 10.42 73 236560 62604 64199495
Influenza like illness 73.10 10.42 71 236562 61631 64200468
Swollen tongue 72.99 10.42 19 236614 34935 64227164
Weight decreased 72.97 10.42 683 235950 285056 63977043
Sopor 72.63 10.42 11 236622 29650 64232449
Mediastinitis 72.26 10.42 42 236591 767 64261332
Osteonecrosis of jaw 71.88 10.42 28 236605 39797 64222302
Perinephric collection 71.38 10.42 31 236602 292 64261807
Enterococcal bacteraemia 71.35 10.42 65 236568 2440 64259659
C-reactive protein abnormal 70.61 10.42 11 236622 29036 64233063
Pericarditis fungal 70.59 10.42 26 236607 151 64261948
Serum sickness 70.54 10.42 72 236561 3117 64258982
Prophylaxis against transplant rejection 70.41 10.42 20 236613 40 64262059
Peritonitis 70.34 10.42 227 236406 24796 64237303
Demodicidosis 70.31 10.42 25 236608 129 64261970
Throat irritation 69.81 10.42 17 236616 32694 64229405
Atypical mycobacterial infection 69.65 10.42 49 236584 1259 64260840
Blood pressure systolic increased 69.65 10.42 48 236585 49405 64212694
Urinary tract infection viral 69.50 10.42 21 236612 57 64262042
Anuria 69.48 10.42 189 236444 18775 64243324
Rash pruritic 69.24 10.42 65 236568 57339 64204760
Biliary tract disorder 69.15 10.42 50 236583 1343 64260756
Vision blurred 69.10 10.42 142 236491 90174 64171925
Hyperglycaemia 69.01 10.42 421 236212 60547 64201552
Urinoma 68.66 10.42 26 236607 165 64261934
Ill-defined disorder 68.64 10.42 38 236595 44014 64218085
Photodermatosis 68.51 10.42 42 236591 849 64261250
Portal vein thrombosis 68.47 10.42 88 236545 4903 64257196
Anaphylactic reaction 68.31 10.42 91 236542 68573 64193526
Babesiosis 68.21 10.42 29 236604 258 64261841
Blood pressure decreased 68.12 10.42 133 236500 86066 64176033
Oliguria 67.76 10.42 159 236474 14417 64247682
Meningitis viral 67.75 10.42 54 236579 1684 64260415
Acute myocardial infarction 67.74 10.42 94 236539 69624 64192475
Penicillium infection 67.65 10.42 27 236606 201 64261898
Leukoencephalopathy 67.52 10.42 104 236529 6863 64255236
Chills 67.30 10.42 267 236366 136997 64125102
Hepatic artery stenosis 67.16 10.42 24 236609 126 64261973
White blood cell count decreased 67.07 10.42 324 236309 157513 64104586
Hepatic enzyme increased 66.77 10.42 248 236385 129695 64132404
Epstein-Barr virus associated lymphoma 66.73 10.42 42 236591 891 64261208
Drug effective for unapproved indication 66.65 10.42 75 236558 3633 64258466
Central nervous system infection 66.55 10.42 46 236587 1148 64260951
Graft versus host disease in eye 66.51 10.42 29 236604 276 64261823
Neutrophil count decreased 66.45 10.42 113 236520 77083 64185016
Ileal ulcer 66.20 10.42 43 236590 965 64261134
Toxic optic neuropathy 66.15 10.42 42 236591 905 64261194
Hepatitis B 65.97 10.42 109 236524 7636 64254463
Capillaritis 65.87 10.42 27 236606 217 64261882
Choriomeningitis lymphocytic 65.31 10.42 19 236614 43 64262056
Heart rate irregular 65.25 10.42 11 236622 27402 64234697
Aggression 64.94 10.42 45 236588 46187 64215912
Hyperkalaemia 64.93 10.42 611 236022 100518 64161581
Coccidioidomycosis 64.65 10.42 44 236589 1070 64261029
Pre-eclampsia 64.63 10.42 96 236537 6135 64255964
Hyperammonaemia 64.56 10.42 124 236509 9780 64252319
Urinary fistula 64.48 10.42 20 236613 61 64262038
Full blood count abnormal 64.42 10.42 15 236618 29742 64232357
Superinfection bacterial 64.35 10.42 45 236588 1145 64260954
Dermatitis atopic 63.94 10.42 75 236558 3801 64258298
Central nervous system fungal infection 63.45 10.42 31 236602 391 64261708
Dehydration 62.95 10.42 501 236132 216262 64045837
Visceral leishmaniasis 62.89 10.42 41 236592 926 64261173
Presyncope 62.79 10.42 25 236608 35064 64227035
Body temperature decreased 62.61 10.42 10 236623 25918 64236181
Histology abnormal 62.58 10.42 28 236605 285 64261814
Disseminated varicella zoster virus infection 62.48 10.42 27 236606 251 64261848
Hip arthroplasty 62.45 10.42 4 236629 21347 64240752
Haemodynamic instability 62.19 10.42 156 236477 14756 64247343
Transient ischaemic attack 62.07 10.42 43 236590 44139 64217960
Injection site haemorrhage 61.81 10.42 8 236625 24270 64237829
Thrombotic thrombocytopenic purpura 61.79 10.42 92 236541 5892 64256207
Device expulsion 61.70 10.42 4 236629 21132 64240967
Drug level below therapeutic 61.66 10.42 103 236530 7281 64254818
Wound dehiscence 61.64 10.42 91 236542 5783 64256316
Red blood cell sedimentation rate increased 61.47 10.42 19 236614 31216 64230883
Dysphonia 61.45 10.42 48 236585 46334 64215765
Device issue 61.33 10.42 6 236627 22642 64239457
Pulmonary alveolar haemorrhage 61.13 10.42 120 236513 9618 64252481
Stomatitis 61.13 10.42 202 236431 109403 64152696
Trichosporon infection 60.92 10.42 39 236594 853 64261246
Dysplasia 60.92 10.42 43 236590 1111 64260988
Abdominal infection 60.75 10.42 64 236569 2876 64259223
Cerebral fungal infection 60.44 10.42 28 236605 311 64261788
Disseminated cytomegaloviral infection 60.27 10.42 30 236603 395 64261704
Intentional product misuse 60.25 10.42 108 236525 72187 64189912
Exposure during pregnancy 60.11 10.42 489 236144 77186 64184913
Gastroenteritis adenovirus 60.04 10.42 26 236607 243 64261856
Fusarium infection 59.56 10.42 48 236585 1521 64260578
Post procedural urine leak 59.55 10.42 22 236611 129 64261970
Endocarditis 59.40 10.42 116 236517 9262 64252837
Bone marrow failure 59.34 10.42 339 236294 47613 64214486
Haematemesis 59.34 10.42 51 236582 46948 64215151
Cystitis viral 59.32 10.42 34 236599 604 64261495
Cutaneous T-cell lymphoma 59.25 10.42 57 236576 2295 64259804
Renal tubular disorder 58.91 10.42 90 236543 5897 64256202
Angiosarcoma metastatic 58.89 10.42 17 236616 37 64262062
Microangiopathy 58.74 10.42 47 236586 1474 64260625
Granuloma 58.65 10.42 95 236538 6546 64255553
MELAS syndrome 58.58 10.42 22 236611 136 64261963
Fluid retention 58.28 10.42 80 236553 59526 64202573
Muir-Torre syndrome 58.27 10.42 17 236616 39 64262060
Respiratory arrest 58.22 10.42 65 236568 52920 64209179
Pleural effusion 58.13 10.42 715 235918 125844 64136255
Mycetoma mycotic 58.11 10.42 20 236613 92 64262007
Oesophageal candidiasis 58.04 10.42 105 236528 7912 64254187
Dysplastic naevus 57.96 10.42 31 236602 478 64261621
B-cell lymphoma 57.93 10.42 85 236548 5372 64256727
Ureteral necrosis 57.92 10.42 19 236614 73 64262026
Burkholderia cepacia complex infection 57.91 10.42 26 236607 267 64261832
Lymphocytic infiltration 57.69 10.42 45 236588 1359 64260740
Disseminated tuberculosis 57.60 10.42 69 236564 3576 64258523
Joint injury 57.37 10.42 8 236625 22939 64239160
Fungaemia 57.12 10.42 70 236563 3715 64258384
Poor quality sleep 57.11 10.42 3 236630 18948 64243151
Staphylococcal sepsis 57.03 10.42 138 236495 12761 64249338
Complications of bone marrow transplant 56.81 10.42 33 236600 602 64261497
Locked-in syndrome 56.76 10.42 33 236600 603 64261496
Burning sensation 56.71 10.42 59 236574 49605 64212494
Sebaceous carcinoma 56.44 10.42 20 236613 102 64261997
Oesophageal ulcer 56.43 10.42 90 236543 6120 64255979
Primary effusion lymphoma 56.33 10.42 16 236617 32 64262067
Herpes simplex hepatitis 56.07 10.42 29 236604 416 64261683
Vertigo 55.90 10.42 81 236552 58930 64203169
Disseminated mycobacterium avium complex infection 55.10 10.42 19 236614 88 64262011
Arteritis infective 54.90 10.42 18 236615 69 64262030
Road traffic accident 54.86 10.42 22 236611 30723 64231376
Perinephric abscess 54.85 10.42 23 236610 197 64261902
Cognitive disorder 54.80 10.42 73 236560 55014 64207085
Chronic graft versus host disease in intestine 54.42 10.42 25 236608 272 64261827
Mycobacterium chelonae infection 54.23 10.42 52 236581 2085 64260014
Disseminated trichosporonosis 54.11 10.42 18 236615 73 64262026
Subcapsular renal haematoma 54.05 10.42 33 236600 662 64261437
Epstein Barr virus positive mucocutaneous ulcer 53.96 10.42 33 236600 664 64261435
Klebsiella sepsis 53.86 10.42 57 236576 2575 64259524
Meningitis bacterial 53.84 10.42 54 236579 2289 64259810
Hepatosplenic T-cell lymphoma 53.82 10.42 35 236598 787 64261312
Accidental exposure to product 53.78 10.42 15 236618 26349 64235750
Solar lentigo 53.53 10.42 36 236597 858 64261241
Coronary artery disease 53.37 10.42 87 236546 60346 64201753
Drug withdrawal syndrome 53.25 10.42 24 236609 31267 64230832
Malacoplakia vesicae 53.16 10.42 17 236616 59 64262040
Feeling cold 53.15 10.42 11 236622 23667 64238432
Idiopathic pneumonia syndrome 53.05 10.42 30 236603 519 64261580
Chimerism 52.99 10.42 24 236609 252 64261847
Cutaneous blastomycosis 52.81 10.42 15 236618 30 64262069
Atypical mycobacterial pneumonia 52.80 10.42 20 236613 127 64261972
Legionella infection 52.72 10.42 33 236600 693 64261406
Limb discomfort 52.64 10.42 17 236616 27158 64234941
Cardiac disorder 52.50 10.42 77 236556 55739 64206360
Necrotising retinitis 52.41 10.42 38 236595 1025 64261074
Candida sepsis 52.39 10.42 52 236581 2176 64259923
Pneumonia influenzal 52.29 10.42 55 236578 2467 64259632
Varicella 52.29 10.42 56 236577 2565 64259534
Chromoblastomycosis 52.09 10.42 17 236616 64 64262035
Emotional distress 52.06 10.42 34 236599 36004 64226095
Anaphylactic shock 52.03 10.42 23 236610 30305 64231794
Parainfluenzae virus infection 51.98 10.42 75 236558 4668 64257431
Thyroid gland abscess 51.68 10.42 17 236616 66 64262033
Device dislocation 51.52 10.42 8 236625 21170 64240929
Muscular weakness 51.45 10.42 266 236367 127072 64135027
Irritability 51.30 10.42 36 236597 36710 64225389
Injection site mass 51.22 10.42 3 236630 17267 64244832
Respiratory syncytial virus infection 51.11 10.42 94 236539 7174 64254925
Neoplasm progression 51.05 10.42 45 236588 40919 64221180
Medication error 50.95 10.42 65 236568 49901 64212198
Lactic acidosis 50.94 10.42 92 236541 61318 64200781
Gastroenteritis cryptosporidial 50.74 10.42 23 236610 242 64261857
Joint stiffness 50.69 10.42 24 236609 30380 64231719
Upper respiratory fungal infection 50.55 10.42 24 236609 283 64261816
Meningoencephalitis viral 50.27 10.42 26 236607 373 64261726
Transitional cell carcinoma 50.15 10.42 51 236582 2198 64259901
Drug dependence 50.10 10.42 30 236603 33282 64228817
Enterovirus infection 49.93 10.42 42 236591 1415 64260684
Evans syndrome 49.66 10.42 26 236607 383 64261716
Brain oedema 49.66 10.42 186 236447 21889 64240210
Tinnitus 49.59 10.42 32 236601 34101 64227998
Ventricular remodelling 49.53 10.42 18 236615 100 64261999
Abdominal distension 49.44 10.42 183 236450 95811 64166288
Angioedema 49.17 10.42 95 236538 61726 64200373
Fungal sepsis 49.15 10.42 44 236589 1614 64260485
Hepatic necrosis 49.11 10.42 101 236532 8372 64253727
Pneumopericardium 48.97 10.42 19 236614 130 64261969
Fungal abscess central nervous system 48.95 10.42 18 236615 104 64261995
Pleocytosis 48.81 10.42 37 236596 1070 64261029
Head injury 48.80 10.42 30 236603 32812 64229287
Shock haemorrhagic 48.72 10.42 154 236479 16637 64245462
Rhinorrhoea 48.71 10.42 91 236542 59878 64202221
Respiratory distress 48.66 10.42 344 236289 51987 64210112
Histoplasmosis cutaneous 48.64 10.42 14 236619 30 64262069
Adverse drug reaction 48.62 10.42 57 236576 45407 64216692
Anti-erythropoietin antibody negative 48.53 10.42 23 236610 270 64261829
Infectious thyroiditis 48.52 10.42 18 236615 107 64261992
Hepatocellular carcinoma 48.51 10.42 100 236533 8303 64253796
Hepatitis cholestatic 48.45 10.42 125 236508 12030 64250069
Human herpesvirus 6 infection reactivation 48.23 10.42 23 236610 274 64261825
Microangiopathic haemolytic anaemia 48.20 10.42 40 236593 1322 64260777
Normocytic anaemia 48.16 10.42 60 236573 3239 64258860
Optic atrophy 48.14 10.42 44 236589 1659 64260440
Heartland virus infection 48.10 10.42 12 236621 10 64262089
Subcutaneous abscess 48.07 10.42 90 236543 6963 64255136
Biloma 48.00 10.42 19 236614 138 64261961
Musculoskeletal disorder 47.82 10.42 5 236628 17901 64244198
Gait inability 47.63 10.42 51 236582 42317 64219782
Mycobacterium haemophilum infection 47.59 10.42 15 236618 49 64262050
Pulmonary tuberculosis 47.59 10.42 91 236542 7153 64254946
Dyspnoea exertional 47.52 10.42 127 236506 73603 64188496
Proteus infection 47.52 10.42 43 236590 1600 64260499
Leiomyosarcoma 47.52 10.42 22 236611 244 64261855
Neuroendocrine carcinoma of the skin 47.36 10.42 35 236598 973 64261126
Hip fracture 47.36 10.42 20 236613 27079 64235020
Central nervous system viral infection 47.15 10.42 17 236616 92 64262007
Meningomyelitis herpes 47.14 10.42 15 236618 51 64262048
Cholestasis 47.13 10.42 304 236329 44568 64217531
Bone marrow transplant rejection 47.13 10.42 22 236611 249 64261850
Metastatic squamous cell carcinoma 47.11 10.42 26 236607 428 64261671
Enteritis 46.91 10.42 123 236510 11954 64250145
Lung consolidation 46.77 10.42 94 236539 7664 64254435
Nervousness 46.77 10.42 25 236608 29531 64232568
Electrocardiogram QT prolonged 46.69 10.42 143 236490 79305 64182794
Glomerulonephritis membranous 46.69 10.42 39 236594 1301 64260798
Angina pectoris 46.64 10.42 58 236575 45023 64217076
Adult T-cell lymphoma/leukaemia 46.60 10.42 23 236610 297 64261802
Haemolysis 46.58 10.42 116 236517 10923 64251176
Depressed mood 46.51 10.42 49 236584 40963 64221136
Vascular hyalinosis 46.44 10.42 13 236620 24 64262075
Encephalitis autoimmune 46.22 10.42 45 236588 1839 64260260
Lethargy 46.07 10.42 126 236507 72468 64189631
Transplantation complication 45.99 10.42 21 236612 225 64261874
Injection site rash 45.89 10.42 3 236630 15739 64246360
Flatulence 45.88 10.42 38 236595 35628 64226471
Necrosis 45.72 10.42 96 236537 8075 64254024
Oesophageal stenosis 45.53 10.42 63 236570 3771 64258328
Dysphagia 45.51 10.42 219 236414 106593 64155506
Prostatitis 45.47 10.42 61 236572 3545 64258554
Brain herniation 45.32 10.42 84 236549 6449 64255650
Underdose 45.24 10.42 19 236614 25810 64236289
Tooth disorder 45.23 10.42 13 236620 22389 64239710
Blood cholesterol increased 45.22 10.42 71 236562 49995 64212104
Cutaneous nocardiosis 44.99 10.42 19 236614 166 64261933
Hallucination 44.96 10.42 128 236505 72660 64189439
Engraft failure 44.94 10.42 28 236605 583 64261516
Klebsiella bacteraemia 44.94 10.42 49 236584 2291 64259808
Blood pressure diastolic decreased 44.91 10.42 13 236620 22288 64239811
Lip swelling 44.89 10.42 31 236602 31876 64230223
Hyponatraemia 44.85 10.42 339 236294 148000 64114099
Tularaemia 44.77 10.42 16 236617 84 64262015
Urosepsis 44.68 10.42 180 236453 21914 64240185
Hypertrophic osteoarthropathy 44.61 10.42 17 236616 110 64261989
Disseminated toxoplasmosis 44.53 10.42 18 236615 139 64261960
Reticulocytopenia 44.31 10.42 19 236614 173 64261926
Renal vein thrombosis 44.23 10.42 25 236608 432 64261667
Graft infection 44.12 10.42 28 236605 603 64261496
Labelled drug-drug interaction medication error 44.03 10.42 179 236454 21883 64240216
Illness 43.80 10.42 13 236620 21925 64240174
Crying 43.74 10.42 10 236623 20080 64242019
Loss of personal independence in daily activities 43.59 10.42 129 236504 72325 64189774
Clostridial infection 43.54 10.42 72 236561 5047 64257052
Disease progression 43.20 10.42 323 236310 141357 64120742
Pancreatitis necrotising 43.00 10.42 56 236577 3161 64258938
Inflammatory bowel disease 42.94 10.42 67 236566 4471 64257628
Cold sweat 42.92 10.42 5 236628 16450 64245649
Granulomatous rosacea 42.76 10.42 19 236614 190 64261909
Eye infection toxoplasmal 42.75 10.42 25 236608 462 64261637
Disseminated aspergillosis 42.66 10.42 28 236605 640 64261459
Serratia infection 42.59 10.42 39 236594 1474 64260625
Limbic encephalitis 42.54 10.42 28 236605 643 64261456
Speech disorder 42.53 10.42 70 236563 48371 64213728
Aspergilloma 42.51 10.42 25 236608 467 64261632
Full blood count decreased 42.22 10.42 15 236618 22567 64239532
Device malfunction 42.13 10.42 7 236626 17626 64244473
Femur fracture 41.93 10.42 38 236595 34097 64228002
C3 glomerulopathy 41.92 10.42 12 236621 25 64262074
Bone marrow transplant 41.85 10.42 36 236597 1251 64260848
Ecthyma 41.60 10.42 27 236606 605 64261494
Rib fracture 41.60 10.42 18 236615 24020 64238079
Disseminated varicella zoster vaccine virus infection 41.54 10.42 16 236617 107 64261992
Bronchiolitis obliterans syndrome 41.52 10.42 20 236613 244 64261855
Hepatosplenomegaly 41.28 10.42 72 236561 5271 64256828
Rhinovirus infection 41.27 10.42 78 236555 6078 64256021
Skin laceration 41.13 10.42 19 236614 24398 64237701
Anastomotic stenosis 40.73 10.42 24 236609 450 64261649
Foot deformity 40.69 10.42 6 236627 16498 64245601
Skin squamous cell carcinoma metastatic 40.46 10.42 13 236620 46 64262053
Toxicity to various agents 40.39 10.42 1674 234959 361839 63900260
Restlessness 40.31 10.42 52 236581 39733 64222366
Localised infection 40.22 10.42 31 236602 30130 64231969
T-cell lymphoma 40.01 10.42 34 236599 1162 64260937
Pleural mesothelioma malignant 39.91 10.42 17 236616 152 64261947
Postoperative wound infection 39.87 10.42 105 236528 10231 64251868
Respiratory depression 39.86 10.42 18 236615 23425 64238674
Red blood cell count decreased 39.67 10.42 73 236560 48313 64213786
Eye swelling 39.66 10.42 16 236617 22265 64239834
Herpes zoster meningoencephalitis 39.44 10.42 27 236606 663 64261436
Systemic bacterial infection 39.40 10.42 11 236622 20 64262079
Skin squamous cell carcinoma recurrent 39.34 10.42 12 236621 34 64262065
Adenovirus reactivation 39.22 10.42 19 236614 235 64261864
Dysstasia 39.20 10.42 18 236615 23197 64238902
Pericarditis constrictive 39.20 10.42 25 236608 543 64261556
Peritonitis pneumococcal 39.06 10.42 11 236622 21 64262078
Mycobacterium marinum infection 38.88 10.42 22 236611 381 64261718
Aortic pseudoaneurysm 38.84 10.42 12 236621 36 64262063
Stevens-Johnson syndrome 38.75 10.42 41 236592 34208 64227891
Psoriasis 38.71 10.42 134 236499 71569 64190530
Renal disorder 38.63 10.42 242 236391 35123 64226976
Renal necrosis 38.59 10.42 19 236614 244 64261855
Citrobacter infection 38.44 10.42 28 236605 761 64261338
Fear 38.40 10.42 13 236620 20158 64241941
Incision site pain 38.31 10.42 48 236585 2606 64259493
Coma 38.28 10.42 178 236455 87437 64174662
Diffuse alveolar damage 38.18 10.42 53 236580 3182 64258917
Vascular pseudoaneurysm 38.10 10.42 52 236581 3072 64259027
Stem cell transplant 38.08 10.42 55 236578 3426 64258673
Gallbladder disorder 38.04 10.42 8 236625 17022 64245077
Injection site warmth 37.99 10.42 3 236630 13459 64248640
Upper gastrointestinal haemorrhage 37.83 10.42 44 236589 35176 64226923
Dyslipidaemia 37.83 10.42 96 236537 9146 64252953
Tonsil cancer 37.79 10.42 30 236603 930 64261169
Escherichia sepsis 37.58 10.42 82 236551 7083 64255016
Overdose 37.50 10.42 389 236244 159177 64102922
Toothache 37.40 10.42 9 236624 17450 64244649
Respiratory tract congestion 37.35 10.42 7 236626 16158 64245941
Encephalomyelitis 37.16 10.42 17 236616 183 64261916
Hepatic cancer recurrent 37.13 10.42 18 236615 223 64261876
Serotonin syndrome 37.13 10.42 54 236579 39228 64222871
Portal hypertension 37.07 10.42 75 236558 6144 64255955
Drug level changed 37.04 10.42 23 236610 476 64261623
Intussusception 36.95 10.42 29 236604 884 64261215
Glomerulonephritis rapidly progressive 36.93 10.42 34 236599 1294 64260805
Muscle spasticity 36.89 10.42 8 236625 16661 64245438
Impaired healing 36.86 10.42 107 236526 60366 64201733
Nosocomial infection 36.81 10.42 46 236587 2491 64259608
Inferior vena cava stenosis 36.81 10.42 12 236621 45 64262054
Intracranial pressure increased 36.67 10.42 80 236553 6909 64255190
Cryptococcal cutaneous infection 36.63 10.42 16 236617 153 64261946
Renal arteriosclerosis 36.57 10.42 18 236615 231 64261868
Hepatic vein occlusion 36.54 10.42 16 236617 154 64261945
Cholangitis sclerosing 36.53 10.42 40 236593 1879 64260220
Impaired work ability 36.46 10.42 6 236627 15213 64246886
Hepatitis C virus test 36.42 10.42 13 236620 68 64262031
Skin lesion 36.39 10.42 244 236389 36238 64225861
Protothecosis 36.37 10.42 11 236622 30 64262069
Urinary tract infection enterococcal 36.24 10.42 49 236584 2869 64259230
Vesicoureteric reflux 36.18 10.42 14 236619 95 64262004
Lymphoma 36.09 10.42 123 236510 13818 64248281
Aspartate aminotransferase increased 36.08 10.42 274 236359 119514 64142585
Body temperature increased 36.05 10.42 49 236584 36617 64225482
Throat tightness 36.05 10.42 20 236613 23140 64238959
Renal haematoma 36.03 10.42 26 236607 696 64261403
Anger 35.98 10.42 7 236626 15734 64246365
Hypothyroidism 35.95 10.42 58 236575 40399 64221700
Nightmare 35.88 10.42 16 236617 20977 64241122
Cutaneous tuberculosis 35.84 10.42 17 236616 200 64261899
Skin mass 35.77 10.42 80 236553 7026 64255073
Parvovirus infection 35.76 10.42 24 236609 570 64261529
Hypoalbuminaemia 35.75 10.42 144 236489 17530 64244569
Blood calcium decreased 35.72 10.42 25 236608 25529 64236570
Sinus disorder 35.66 10.42 9 236624 16899 64245200
Acute hepatitis C 35.62 10.42 17 236616 203 64261896
Biopsy kidney abnormal 35.58 10.42 16 236617 165 64261934
Metastases to lung 35.50 10.42 130 236503 15134 64246965
Platelet count decreased 35.39 10.42 419 236214 167292 64094807
Neurological symptom 35.37 10.42 78 236555 6786 64255313
Gastric disorder 35.28 10.42 33 236600 29164 64232935
Splenomegaly 35.27 10.42 145 236488 17816 64244283
Disseminated blastomycosis 35.22 10.42 14 236619 103 64261996
Pulmonary haemorrhage 35.12 10.42 117 236516 12992 64249107
Pyelonephritis fungal 35.10 10.42 14 236619 104 64261995
Arterial rupture 34.90 10.42 26 236607 732 64261367
Faeces discoloured 34.88 10.42 26 236607 25703 64236396
Oesophageal achalasia 34.78 10.42 25 236608 665 64261434
Multiple sclerosis 34.71 10.42 13 236620 18928 64243171
Obstructive nephropathy 34.66 10.42 11 236622 37 64262062
Gastritis fungal 34.59 10.42 16 236617 177 64261922
Urate nephropathy 34.56 10.42 15 236618 141 64261958
Hepatic vein stenosis 34.56 10.42 12 236621 57 64262042
Morganella infection 34.47 10.42 29 236604 977 64261122
Cholelithiasis 34.42 10.42 72 236561 45434 64216665
Pharyngeal polyp 34.36 10.42 9 236624 11 64262088
Amnesia 34.34 10.42 79 236554 48190 64213909
Chemical peritonitis 34.33 10.42 18 236615 266 64261833
Panic attack 34.23 10.42 17 236616 20936 64241163
Depressed level of consciousness 34.09 10.42 168 236465 81268 64180831
Septic embolus 34.02 10.42 37 236596 1725 64260374
Renal and pancreas transplant rejection 34.00 10.42 11 236622 40 64262059
Ureteric anastomosis complication 33.97 10.42 10 236623 24 64262075
Hepatitis C RNA increased 33.71 10.42 20 236613 380 64261719
Granulomatous dermatitis 33.68 10.42 19 236614 327 64261772
Blood test abnormal 33.59 10.42 4 236629 12939 64249160
Disability 33.56 10.42 3 236630 12169 64249930
Sarcoma of skin 33.42 10.42 12 236621 64 64262035
Tachycardia 33.39 10.42 369 236264 149210 64112889
Rotator cuff syndrome 33.34 10.42 3 236630 12104 64249995
Plasmablastic lymphoma 33.30 10.42 20 236613 389 64261710
Pneumonia herpes viral 33.24 10.42 15 236618 156 64261943
Kidney rupture 33.23 10.42 16 236617 195 64261904
Pollakiuria 33.21 10.42 40 236593 31490 64230609
Palmar-plantar erythrodysaesthesia syndrome 33.17 10.42 34 236599 28785 64233314
Pallor 33.16 10.42 57 236576 38724 64223375
Nephritis haemorrhagic 33.11 10.42 9 236624 14 64262085
Angina unstable 33.08 10.42 8 236625 15459 64246640
Abnormal behaviour 32.99 10.42 45 236588 33577 64228522
Surgical procedure repeated 32.99 10.42 24 236609 651 64261448
Diabetic cardiomyopathy 32.87 10.42 10 236623 28 64262071
Renal abscess 32.86 10.42 27 236606 880 64261219
Disturbance in attention 32.77 10.42 63 236570 41011 64221088
Pseudomonal bacteraemia 32.70 10.42 41 236592 2228 64259871
Cat scratch disease 32.68 10.42 17 236616 247 64261852
Hypertensive emergency 32.60 10.42 41 236592 2235 64259864
Immune-mediated adverse reaction 32.42 10.42 25 236608 742 64261357
Respiratory tract infection fungal 32.41 10.42 29 236604 1063 64261036
Endocarditis enterococcal 32.41 10.42 14 236619 130 64261969
Infective pulmonary exacerbation of cystic fibrosis 32.27 10.42 3 236630 11793 64250306
Anorexia nervosa 32.27 10.42 15 236618 168 64261931
Glomerulonephritis proliferative 32.26 10.42 19 236614 356 64261743
Hypersomnia 32.20 10.42 16 236617 19701 64242398
Metastatic malignant melanoma 32.06 10.42 43 236590 2498 64259601
Photosensitivity reaction 32.04 10.42 142 236491 18031 64244068
Mood swings 31.99 10.42 12 236621 17456 64244643
Nephritis 31.98 10.42 52 236581 3594 64258505
Sporotrichosis 31.98 10.42 12 236621 74 64262025
Erythropoiesis abnormal 31.95 10.42 20 236613 420 64261679
Skin discolouration 31.83 10.42 50 236583 35205 64226894
Breast cancer 31.75 10.42 36 236597 29112 64232987
Bone disorder 31.56 10.42 11 236622 16748 64245351
Hypoacusis 31.53 10.42 29 236604 25838 64236261
Gastrointestinal toxicity 31.51 10.42 64 236569 5258 64256841
Deep vein thrombosis 31.48 10.42 241 236392 104941 64157158
Cerebral microhaemorrhage 31.36 10.42 15 236618 180 64261919
Lacrimation increased 31.33 10.42 14 236619 18332 64243767
Pyrexia 31.25 10.42 2416 234217 556228 63705871
Pancreas transplant 31.22 10.42 11 236622 55 64262044
Dialysis 31.20 10.42 134 236499 16786 64245313
Viral test positive 31.13 10.42 19 236614 381 64261718
Bone marrow oedema 31.12 10.42 29 236604 1121 64260978
Herpes virus infection 31.10 10.42 70 236563 6174 64255925
Sinus congestion 31.09 10.42 9 236624 15430 64246669
Porokeratosis 31.03 10.42 16 236617 228 64261871
Hyperuricaemia 30.98 10.42 95 236538 10096 64252003
Muscle abscess 30.98 10.42 26 236607 873 64261226
Corneal endotheliitis 30.90 10.42 11 236622 57 64262042
Tendonitis 30.87 10.42 18 236615 20264 64241835
IIIrd nerve paralysis 30.85 10.42 28 236605 1046 64261053
Diarrhoea haemorrhagic 30.79 10.42 101 236532 11126 64250973
Acanthoma 30.78 10.42 10 236623 37 64262062
Gastrointestinal mucormycosis 30.72 10.42 18 236615 334 64261765
Haematochezia 30.71 10.42 132 236501 66241 64195858
Cutaneous leishmaniasis 30.64 10.42 17 236616 283 64261816
Glomerulonephropathy 30.64 10.42 17 236616 283 64261816
Acute generalised exanthematous pustulosis 30.60 10.42 7 236626 14051 64248048
Neuroleptic malignant syndrome 30.50 10.42 28 236605 24968 64237131
Carpal tunnel syndrome 30.48 10.42 10 236623 15818 64246281
Chromaturia 30.46 10.42 23 236610 22588 64239511
Skin graft rejection 30.45 10.42 9 236624 22 64262077
Abdominal wall infection 30.45 10.42 12 236621 86 64262013
Purtscher retinopathy 30.44 10.42 8 236625 10 64262089
Bile duct necrosis 30.44 10.42 8 236625 10 64262089
Paranoia 30.34 10.42 11 236622 16341 64245758
Cryptitis 30.34 10.42 12 236621 87 64262012
Peripheral T-cell lymphoma unspecified 30.29 10.42 22 236611 595 64261504
Limb injury 30.29 10.42 25 236608 23480 64238619
Mycobacterium fortuitum infection 30.17 10.42 15 236618 197 64261902
Microsporum infection 30.17 10.42 10 236623 40 64262059
Drug eruption 30.09 10.42 54 236579 36082 64226017
Influenza 30.08 10.42 248 236385 106283 64155816
Wound infection 29.98 10.42 121 236512 14743 64247356
Intestinal tuberculosis 29.95 10.42 14 236619 159 64261940
Sputum discoloured 29.91 10.42 14 236619 17842 64244257
Aspergillus test positive 29.76 10.42 23 236610 685 64261414
Enterococcal sepsis 29.65 10.42 41 236592 2453 64259646
H1N1 influenza 29.60 10.42 39 236594 2227 64259872
Cataract 29.60 10.42 93 236540 51169 64210930
Toxic skin eruption 29.51 10.42 17 236616 19267 64242832
Apoptosis 29.51 10.42 17 236616 305 64261794
Oxalosis 29.43 10.42 12 236621 95 64262004
Meningoencephalitis amoebic 29.43 10.42 13 236620 128 64261971
Unresponsive to stimuli 29.39 10.42 91 236542 50302 64211797
Central nervous system lesion 29.33 10.42 103 236530 11746 64250353
Nephrocalcinosis 29.29 10.42 30 236603 1304 64260795
Urinary tract infection pseudomonal 29.25 10.42 31 236602 1403 64260696
Intervertebral disc protrusion 29.23 10.42 19 236614 20172 64241927
Urinary incontinence 29.23 10.42 55 236578 36096 64226003
Herpes zoster cutaneous disseminated 29.22 10.42 18 236615 367 64261732
Immunosuppressant drug level 29.22 10.42 8 236625 13 64262086
Angiocentric lymphoma 29.19 10.42 24 236609 783 64261316
Dengue fever 29.16 10.42 24 236609 784 64261315
Emphysematous cystitis 29.14 10.42 15 236618 213 64261886
Acanthamoeba keratitis 29.13 10.42 7 236626 4 64262095
Burkholderia cepacia complex sepsis 29.13 10.42 7 236626 4 64262095
Lymphangiectasia 29.13 10.42 9 236624 27 64262072
Milk allergy 29.11 10.42 12 236621 98 64262001
Immune thrombocytopenia 29.09 10.42 121 236512 14945 64247154
Alanine aminotransferase increased 29.07 10.42 348 236285 138683 64123416
Lupus nephritis 29.04 10.42 40 236593 2384 64259715
Withdrawal syndrome 29.04 10.42 26 236607 23466 64238633
Gastrointestinal lymphoma 28.91 10.42 13 236620 134 64261965
Obesity 28.89 10.42 20 236613 20542 64241557
Encephalitis protozoal 28.88 10.42 9 236624 28 64262071
Endothelial dysfunction 28.84 10.42 14 236619 174 64261925
Dysarthria 28.81 10.42 116 236517 59290 64202809
Akathisia 28.80 10.42 4 236629 11506 64250593
Extranodal marginal zone B-cell lymphoma (MALT type) 28.80 10.42 20 236613 503 64261596
Hepatitis viral 28.79 10.42 25 236608 880 64261219
Gastric haemorrhage 28.78 10.42 7 236626 13474 64248625
Molluscum contagiosum 28.77 10.42 19 236614 439 64261660
Gallbladder rupture 28.75 10.42 24 236609 800 64261299
Face oedema 28.74 10.42 29 236604 24732 64237367
Blood beta-D-glucan increased 28.63 10.42 20 236613 508 64261591
Blood iron decreased 28.61 10.42 5 236628 12137 64249962
Dehiscence 28.60 10.42 12 236621 103 64261996
Hiatus hernia 28.59 10.42 19 236614 19938 64242161
Ejection fraction decreased 28.59 10.42 38 236595 28669 64233430
Viral vasculitis 28.58 10.42 13 236620 138 64261961
Musculoskeletal discomfort 28.47 10.42 12 236621 16265 64245834
Hepatic artery aneurysm 28.42 10.42 9 236624 30 64262069
Tongue disorder 28.41 10.42 5 236628 12075 64250024
Enterobacter pneumonia 28.38 10.42 11 236622 75 64262024
Pelvic deformity 28.38 10.42 11 236622 75 64262024
Oesophageal squamous cell carcinoma 28.35 10.42 19 236614 450 64261649
Dermatitis allergic 28.31 10.42 10 236623 15099 64247000
Liver function test abnormal 28.30 10.42 338 236295 59063 64203036
Hyperplasia 28.27 10.42 27 236606 1077 64261022
Viral load increased 28.24 10.42 40 236593 2447 64259652
Epstein-Barr virus antibody positive 28.23 10.42 21 236612 590 64261509
Portal vein occlusion 28.19 10.42 9 236624 31 64262068
Wound infection fungal 28.15 10.42 14 236619 184 64261915
Papule 28.14 10.42 68 236565 6282 64255817
Infectious pleural effusion 28.12 10.42 43 236590 2819 64259280
Cryoglobulinaemia 28.10 10.42 22 236611 668 64261431
Diverticulitis intestinal perforated 28.06 10.42 10 236623 52 64262047
Abortion spontaneous 28.05 10.42 173 236460 24970 64237129
Cardiac valve vegetation 28.02 10.42 24 236609 829 64261270
Status epilepticus 28.02 10.42 155 236478 21508 64240591
Anaplastic large cell lymphoma T- and null-cell types 28.01 10.42 12 236621 109 64261990
Product complaint 28.00 10.42 5 236628 11949 64250150
Pulmonary arterial hypertension 28.00 10.42 31 236602 25336 64236763
Renal vessel disorder 27.98 10.42 16 236617 283 64261816
Cell death 27.96 10.42 52 236581 4002 64258097
Febrile bone marrow aplasia 27.96 10.42 4 236629 11251 64250848
Urinary retention 27.89 10.42 90 236543 49111 64212988
Arrhythmia 27.87 10.42 100 236533 52844 64209255
Alpha haemolytic streptococcal infection 27.83 10.42 33 236600 1692 64260407
Abdominal wall abscess 27.80 10.42 26 236607 1010 64261089
Delayed engraftment 27.72 10.42 15 236618 237 64261862
Prostatic abscess 27.71 10.42 17 236616 344 64261755
Petechiae 27.69 10.42 17 236616 18609 64243490
Sinusitis aspergillus 27.69 10.42 14 236619 191 64261908
Urine output decreased 27.68 10.42 127 236506 16365 64245734
Paraesthesia oral 27.68 10.42 7 236626 13124 64248975
Splenic vein thrombosis 27.66 10.42 22 236611 684 64261415
Eye abscess 27.63 10.42 16 236617 290 64261809
Upper limb fracture 27.58 10.42 10 236623 14856 64247243
Troponin increased 27.50 10.42 11 236622 15388 64246711
Bursitis 27.50 10.42 23 236610 21462 64240637
Musculoskeletal chest pain 27.49 10.42 23 236610 21456 64240643
Burkitt's lymphoma 27.45 10.42 12 236621 115 64261984
Tick-borne viral encephalitis 27.43 10.42 11 236622 83 64262016
Blood immunoglobulin G decreased 27.34 10.42 41 236592 2642 64259457
Dry eye 27.32 10.42 40 236593 28979 64233120
Fungal peritonitis 27.27 10.42 25 236608 946 64261153
Grip strength decreased 27.26 10.42 5 236628 11719 64250380
Propionibacterium infection 27.25 10.42 16 236617 298 64261801
Hepatic function abnormal 27.24 10.42 358 236275 63955 64198144
Peripheral coldness 27.21 10.42 8 236625 13576 64248523
Enterocolitis viral 27.20 10.42 16 236617 299 64261800
Zoonotic bacterial infection 27.16 10.42 10 236623 58 64262041
Superinfection viral 27.15 10.42 9 236624 36 64262063
Vaccination failure 27.12 10.42 24 236609 867 64261232
Tuberculosis gastrointestinal 27.12 10.42 19 236614 485 64261614
Toxic epidermal necrolysis 27.11 10.42 60 236573 37106 64224993
Lymphadenopathy mediastinal 27.09 10.42 50 236583 3826 64258273
Reversible cerebral vasoconstriction syndrome 27.09 10.42 38 236595 2304 64259795
Colorectal cancer 26.99 10.42 45 236588 3176 64258923
Blood glucose decreased 26.93 10.42 27 236606 23096 64239003
Encephalitis fungal 26.89 10.42 13 236620 160 64261939
Adenovirus test positive 26.88 10.42 10 236623 60 64262039
Necrotising fasciitis 26.86 10.42 60 236573 5266 64256833
Hepatitis B reactivation 26.84 10.42 57 236576 4832 64257267
Acinetobacter bacteraemia 26.81 10.42 14 236619 205 64261894
Cyanosis 26.81 10.42 25 236608 22130 64239969
Dyskinesia 26.80 10.42 66 236567 39322 64222777
Tooth infection 26.79 10.42 10 236623 14591 64247508
Restrictive allograft syndrome 26.67 10.42 8 236625 21 64262078
Hepatic haematoma 26.60 10.42 23 236610 805 64261294
Pancreatitis acute 26.53 10.42 257 236376 42598 64219501
Oral hairy leukoplakia 26.53 10.42 7 236626 9 64262090
Drug level abnormal 26.47 10.42 13 236620 166 64261933
Salivary hypersecretion 26.43 10.42 6 236627 12107 64249992
Complications of transplanted pancreas 26.40 10.42 8 236625 22 64262077
Pharyngeal oedema 26.29 10.42 12 236621 15519 64246580
Aplastic anaemia 26.25 10.42 111 236522 13809 64248290
Miosis 26.23 10.42 8 236625 13258 64248841
Acid fast bacilli infection 26.08 10.42 12 236621 131 64261968
Pulmonary mass 26.01 10.42 164 236469 23852 64238247
Sinus tachycardia 26.00 10.42 49 236584 32139 64229960
Enterocolitis 25.99 10.42 100 236533 11918 64250181
Myopathy 25.95 10.42 131 236502 17549 64244550
Lung adenocarcinoma 25.93 10.42 69 236564 6764 64255335
Necrotising colitis 25.92 10.42 24 236609 920 64261179
Protein urine present 25.85 10.42 82 236551 8874 64253225
Intervertebral disc degeneration 25.78 10.42 8 236625 13112 64248987
Oral pain 25.78 10.42 38 236595 27455 64234644
Cyclosporidium infection 25.71 10.42 7 236626 11 64262088
Chronic papillomatous dermatitis 25.70 10.42 10 236623 69 64262030
Dementia 25.65 10.42 23 236610 20743 64241356
Type 2 diabetes mellitus 25.58 10.42 54 236579 33966 64228133
Mucosal hypertrophy 25.54 10.42 9 236624 45 64262054
Eating disorder 25.46 10.42 15 236618 16790 64245309
Tuberculosis 25.40 10.42 105 236528 12933 64249166
Genital herpes 25.35 10.42 33 236600 1862 64260237
Pathergy reaction 25.34 10.42 7 236626 12 64262087
Rabies 25.34 10.42 7 236626 12 64262087
Escherichia pyelonephritis 25.33 10.42 18 236615 470 64261629
Type 1 diabetes mellitus 25.18 10.42 61 236572 5644 64256455
Thyroid disorder 25.10 10.42 6 236627 11686 64250413
Incorrect dose administered 25.06 10.42 126 236507 60639 64201460
Middle insomnia 25.04 10.42 8 236625 12869 64249230
Large intestine perforation 24.94 10.42 102 236531 12502 64249597
Isosporiasis 24.93 10.42 11 236622 108 64261991
Steroid withdrawal syndrome 24.92 10.42 20 236613 630 64261469
Phaeohyphomycotic brain abscess 24.92 10.42 9 236624 49 64262050
Toxic encephalopathy 24.88 10.42 86 236547 9729 64252370
Abscess fungal 24.82 10.42 14 236619 241 64261858
Roseolovirus test positive 24.80 10.42 13 236620 192 64261907
Biliary fistula 24.77 10.42 10 236623 77 64262022
Muscle twitching 24.74 10.42 20 236613 18978 64243121
Enterococcus test positive 24.73 10.42 31 236602 1684 64260415
Lymphadenitis fungal 24.62 10.42 6 236627 4 64262095
Continuous haemodiafiltration 24.61 10.42 33 236600 1917 64260182
Mycoplasma test positive 24.56 10.42 13 236620 196 64261903
Cow pox 24.54 10.42 8 236625 30 64262069
Hepatic cyst infection 24.52 10.42 12 236621 152 64261947
Viral mutation identified 24.45 10.42 44 236589 3302 64258797
Cytopenia 24.40 10.42 117 236516 15354 64246745
Product quality issue 24.39 10.42 45 236588 29754 64232345
Therapeutic response shortened 24.38 10.42 4 236629 10166 64251933
Basal cell carcinoma 24.31 10.42 195 236438 30643 64231456
Increased appetite 24.30 10.42 4 236629 10142 64251957
Cerebral ventricle collapse 24.24 10.42 11 236622 116 64261983
Pneumonia pneumococcal 24.23 10.42 43 236590 3191 64258908
Trichophytic granuloma 24.19 10.42 9 236624 54 64262045
Beta-N-acetyl-D-glucosaminidase increased 24.19 10.42 9 236624 54 64262045
Frequent bowel movements 24.17 10.42 19 236614 18286 64243813
IVth nerve paralysis 24.11 10.42 12 236621 158 64261941
Catatonia 24.07 10.42 72 236561 7548 64254551
Postoperative thoracic procedure complication 24.05 10.42 9 236624 55 64262044
Conjunctival melanoma 24.05 10.42 6 236627 5 64262094
Eschar 24.05 10.42 25 236608 1106 64260993
Hyperoxaluria 24.02 10.42 14 236619 257 64261842
Nodular melanoma 23.98 10.42 12 236621 160 64261939
Ankle fracture 23.93 10.42 12 236621 14698 64247401
Viral skin infection 23.92 10.42 10 236623 85 64262014
Oligoarthritis 23.88 10.42 15 236618 317 64261782
Post procedural complication 23.87 10.42 147 236486 21206 64240893
Phospholipidosis 23.84 10.42 11 236622 121 64261978
Oral allergy syndrome 23.75 10.42 8 236625 34 64262065
Extrapyramidal disorder 23.74 10.42 22 236611 19530 64242569
Lymphadenopathy 23.73 10.42 269 236364 46417 64215682
Metabolic acidosis 23.71 10.42 379 236254 70579 64191520
Head discomfort 23.65 10.42 7 236626 11827 64250272
Pericardial effusion 23.62 10.42 234 236399 39020 64223079
Graft ischaemia 23.57 10.42 8 236625 35 64262064
Conjunctival neoplasm 23.53 10.42 6 236627 6 64262093
Dyschromatopsia 23.47 10.42 20 236613 686 64261413
Bacterial colitis 23.42 10.42 10 236623 90 64262009
Second primary malignancy 23.40 10.42 8 236625 12329 64249770
Bronchospasm 23.38 10.42 27 236606 21655 64240444
Blood lactate dehydrogenase increased 23.33 10.42 204 236429 32874 64229225
Folliculitis 23.24 10.42 47 236586 30030 64232069
Odynophagia 23.17 10.42 83 236550 9558 64252541
Breath sounds abnormal 23.14 10.42 7 236626 11662 64250437
Renal ischaemia 23.14 10.42 24 236609 1059 64261040
Lip squamous cell carcinoma 23.14 10.42 13 236620 222 64261877
Sinus bradycardia 23.11 10.42 30 236603 22863 64239236
Movement disorder 23.08 10.42 28 236605 21972 64240127
Vascular graft complication 23.07 10.42 11 236622 131 64261968
Optic pathway injury 23.06 10.42 5 236628 0 64262099
Acquired porokeratosis 23.06 10.42 5 236628 0 64262099
Arteriovenous fistula aneurysm 23.06 10.42 5 236628 0 64262099
Escherichia test positive 23.05 10.42 39 236594 2786 64259313
Product storage error 23 10.42 10 236623 13308 64248791
Intrauterine infection 22.90 10.42 9 236624 64 64262035
Mouth ulceration 22.83 10.42 200 236433 32244 64229855
Placenta accreta 22.79 10.42 12 236621 179 64261920
Hyperparathyroidism 22.78 10.42 39 236594 2813 64259286
Surgery 22.74 10.42 43 236590 28170 64233929
Therapy interrupted 22.65 10.42 24 236609 20012 64242087
Metastases to lymph nodes 22.64 10.42 77 236556 8640 64253459
Pneumonia staphylococcal 22.63 10.42 50 236583 4356 64257743
Herpes zoster reactivation 22.59 10.42 10 236623 99 64262000
Anastomotic haemorrhage 22.58 10.42 13 236620 233 64261866
Brucellosis 22.50 10.42 10 236623 100 64261999
Pseudohypoaldosteronism 22.41 10.42 7 236626 22 64262077
Spinal fracture 22.35 10.42 14 236619 15160 64246939
Ocular hyperaemia 22.34 10.42 30 236603 22534 64239565
Abdominal wound dehiscence 22.34 10.42 13 236620 238 64261861
Scrotal ulcer 22.32 10.42 14 236619 295 64261804
Serositis 22.29 10.42 20 236613 736 64261363
Prescribed overdose 22.27 10.42 25 236608 20306 64241793
Disseminated Bacillus Calmette-Guerin infection 22.16 10.42 12 236621 190 64261909
Oesophageal perforation 22.12 10.42 23 236610 1018 64261081
Intraductal papillary mucinous neoplasm 22.11 10.42 18 236615 579 64261520
Neutropenia 22.09 10.42 1083 235550 238541 64023558
Failure to thrive 22.03 10.42 86 236547 10318 64251781
Chylothorax 22.03 10.42 18 236615 582 64261517
Nephrosclerosis 22.02 10.42 28 236605 1543 64260556
Eye disorder 22.01 10.42 22 236611 18847 64243252
Meningitis 22.01 10.42 74 236559 8255 64253844
Clostridium difficile infection 21.96 10.42 216 236417 35947 64226152
Congenital cystic kidney disease 21.96 10.42 13 236620 246 64261853
Fungating wound 21.95 10.42 7 236626 24 64262075
Transplant abscess 21.95 10.42 7 236626 24 64262075
Laboratory test abnormal 21.85 10.42 34 236599 24029 64238070
Coordination abnormal 21.77 10.42 14 236619 14950 64247149
Pyogenic granuloma 21.71 10.42 16 236617 443 64261656
Cholangitis infective 21.71 10.42 16 236617 443 64261656
Blood pressure systolic abnormal 21.54 10.42 5 236628 9937 64252162
Renal cell carcinoma 21.53 10.42 60 236573 6044 64256055
Removal of renal transplant 21.52 10.42 7 236626 26 64262073
Protein-losing gastroenteropathy 21.50 10.42 17 236616 524 64261575
Pancreatic leak 21.46 10.42 6 236627 11 64262088
Leukaemia recurrent 21.42 10.42 36 236597 2558 64259541
Lupus enteritis 21.36 10.42 8 236625 49 64262050
Staphylococcal scalded skin syndrome 21.34 10.42 15 236618 385 64261714
Red blood cell schistocytes present 21.25 10.42 17 236616 533 64261566
Restless legs syndrome 21.09 10.42 19 236614 17097 64245002
Cytomegalovirus mucocutaneous ulcer 21.08 10.42 9 236624 81 64262018
Pregnancy 21.08 10.42 140 236493 20725 64241374
Blood glucose increased 21.07 10.42 244 236389 97829 64164270
Azotaemia 21.03 10.42 68 236565 7434 64254665
Fluoride increased 20.98 10.42 9 236624 82 64262017
Colitis 20.98 10.42 317 236316 58357 64203742
Soft tissue mass 20.98 10.42 21 236612 888 64261211
Aspergillosis oral 20.96 10.42 8 236625 52 64262047
Potentiating drug interaction 20.96 10.42 70 236563 7782 64254317
Blood creatine increased 20.96 10.42 72 236561 8120 64253979
Emotional disorder 20.94 10.42 10 236623 12597 64249502
Pneumococcal infection 20.88 10.42 20 236613 801 64261298
Schistosomiasis 20.84 10.42 8 236625 53 64262046
Paraspinal abscess 20.78 10.42 11 236622 166 64261933
Rhesus antigen positive 20.62 10.42 10 236623 124 64261975
Graft haemorrhage 20.61 10.42 9 236624 86 64262013
Acarodermatitis 20.59 10.42 24 236609 1208 64260891
Angioimmunoblastic T-cell lymphoma 20.58 10.42 15 236618 408 64261691
Immunosuppression 20.51 10.42 86 236547 10660 64251439
Blood pressure diastolic abnormal 20.50 10.42 9 236624 11908 64250191
Arterial thrombosis 20.43 10.42 34 236599 2396 64259703
Chronic inflammatory demyelinating polyradiculoneuropathy 20.41 10.42 21 236612 918 64261181
Renal cortical necrosis 20.40 10.42 13 236620 282 64261817
Meningitis fungal 20.38 10.42 11 236622 173 64261926
Blood sodium decreased 20.37 10.42 49 236584 29433 64232666
Clostridium test positive 20.35 10.42 46 236587 4069 64258030
Blood pressure diastolic increased 20.35 10.42 7 236626 10745 64251354
Pneumonia adenoviral 20.32 10.42 11 236622 174 64261925
Gastroenteritis 20.31 10.42 182 236451 29529 64232570
Sweat gland tumour 20.24 10.42 16 236617 493 64261606
Visual impairment 20.21 10.42 174 236459 73903 64188196
NPM1 gene mutation 20.20 10.42 10 236623 130 64261969
Acute pulmonary histoplasmosis 20.13 10.42 12 236621 230 64261869
Blood albumin increased 20.12 10.42 25 236608 1346 64260753
Renal aneurysm 20.10 10.42 11 236622 178 64261921
Cardiac failure 20.07 10.42 353 236280 132020 64130079
Perihepatic abscess 20.07 10.42 10 236623 132 64261967
Transaminases increased 20.05 10.42 251 236382 44343 64217756
Hernial eventration 19.99 10.42 8 236625 60 64262039
Reperfusion injury 19.99 10.42 11 236622 180 64261919
Incisional hernia 19.98 10.42 31 236602 2059 64260040
Sebaceous adenoma 19.93 10.42 6 236627 16 64262083
Listeriosis 19.93 10.42 30 236603 1940 64260159
Intra-abdominal haemorrhage 19.87 10.42 45 236588 3986 64258113
Abdominal pain 19.83 10.42 940 235693 311435 63950664
T-cell lymphoma stage IV 19.81 10.42 10 236623 136 64261963
Chronic graft versus host disease oral 19.77 10.42 8 236625 62 64262037
Hypernatraemia 19.74 10.42 10 236623 12179 64249920
Diabetic macroangiopathy 19.74 10.42 10 236623 137 64261962
Eye infection fungal 19.72 10.42 15 236618 436 64261663
Myelitis 19.71 10.42 31 236602 2083 64260016
Renal adenoma 19.71 10.42 7 236626 36 64262063
Thrombosis 19.69 10.42 165 236468 70477 64191622
Kaposi sarcoma inflammatory cytokine syndrome 19.67 10.42 6 236627 17 64262082
Scleroderma 19.67 10.42 50 236583 4768 64257331
Renal artery thrombosis 19.66 10.42 15 236618 438 64261661
Cystitis 19.66 10.42 85 236548 42590 64219509
Herpes simplex test positive 19.66 10.42 14 236619 367 64261732
Blood urea increased 19.63 10.42 248 236385 43905 64218194
Angiopathy 19.61 10.42 59 236574 6206 64255893
Tongue ulceration 19.59 10.42 42 236591 3584 64258515
Moyamoya disease 19.55 10.42 8 236625 64 64262035
Tonsillar hypertrophy 19.54 10.42 24 236609 1277 64260822
Hyperamylasaemia 19.50 10.42 20 236613 871 64261228
Jejunal perforation 19.47 10.42 13 236620 306 64261793
Strabismus 19.46 10.42 31 236602 2106 64259993
Pseudomonal sepsis 19.40 10.42 52 236581 5120 64256979
Human herpes virus 8 test positive 19.40 10.42 7 236626 38 64262061
Peritonitis bacterial 19.35 10.42 75 236558 8968 64253131
Neuralgia 19.32 10.42 42 236591 26142 64235957
Hepatic infection fungal 19.31 10.42 11 236622 193 64261906
Food allergy 19.22 10.42 68 236565 7783 64254316
Genitourinary tract infection 19.17 10.42 12 236621 252 64261847
Intestinal ulcer 19.16 10.42 27 236606 1644 64260455
Abnormal dreams 19.16 10.42 7 236626 10349 64251750
Biliary tract infection fungal 19.14 10.42 5 236628 6 64262093
Metastasis 19.13 10.42 55 236578 5640 64256459
Gastroduodenal ulcer 19.06 10.42 15 236618 459 64261640
Hypoaldosteronism 19.03 10.42 13 236620 318 64261781
Bronchial anastomosis complication 18.95 10.42 6 236627 20 64262079
Dry skin 18.93 10.42 110 236523 51051 64211048
Neuropsychiatric lupus 18.88 10.42 10 236623 151 64261948
Acquired macroglossia 18.87 10.42 11 236622 202 64261897
Right ventricular failure 18.87 10.42 31 236602 21440 64240659
Refractoriness to platelet transfusion 18.82 10.42 9 236624 108 64261991
Splenic abscess 18.78 10.42 15 236618 469 64261630
Therapy partial responder 18.77 10.42 81 236552 10167 64251932
Epileptic encephalopathy 18.74 10.42 14 236619 396 64261703
Back injury 18.71 10.42 3 236630 7754 64254345
Autoimmune hepatitis 18.70 10.42 80 236553 10004 64252095
Malignant ascites 18.66 10.42 21 236612 1017 64261082
Pneumonia haemophilus 18.60 10.42 20 236613 920 64261179
Abscess 18.59 10.42 128 236505 19176 64242923
Muscle rigidity 18.58 10.42 22 236611 17451 64244648
Ear infection 18.58 10.42 36 236597 23368 64238731
Bacteriuria 18.57 10.42 20 236613 922 64261177
Affect lability 18.55 10.42 5 236628 8985 64253114
Urinary tract candidiasis 18.53 10.42 17 236616 644 64261455
Renal lymphocele 18.53 10.42 9 236624 112 64261987
Thyroid tuberculosis 18.51 10.42 6 236627 22 64262077
Central nervous system vasculitis 18.49 10.42 22 236611 1132 64260967
Gastrointestinal haemorrhage 18.45 10.42 358 236275 131954 64130145
Mesenteric fibrosis 18.45 10.42 4 236629 0 64262099
Bile duct cancer recurrent 18.45 10.42 4 236629 0 64262099
Multiple organ transplant rejection 18.45 10.42 4 236629 0 64262099
Reactive gastropathy 18.44 10.42 14 236619 406 64261693
Tongue necrosis 18.41 10.42 7 236626 45 64262054
Anhedonia 18.39 10.42 14 236619 13692 64248407
Hallucination, auditory 18.37 10.42 21 236612 16918 64245181
Haemoglobin decreased 18.36 10.42 560 236073 194503 64067596
Product dispensing error 18.35 10.42 87 236546 11363 64250736
Nocturia 18.33 10.42 9 236624 11156 64250943
Lymph node tuberculosis 18.33 10.42 20 236613 936 64261163
Pancreatic pseudocyst haemorrhage 18.31 10.42 5 236628 8 64262091
Pneumothorax 18.26 10.42 152 236481 24146 64237953
Device leakage 18.23 10.42 4 236629 8262 64253837
Pericarditis infective 18.18 10.42 9 236624 117 64261982
Peripancreatic fluid collection 18.15 10.42 7 236626 47 64262052
Central nervous system immune reconstitution inflammatory response 18.15 10.42 7 236626 47 64262052
Sleep disorder due to a general medical condition 18.12 10.42 4 236629 8230 64253869
Erectile dysfunction 18.12 10.42 12 236621 12615 64249484
Biliary ischaemia 18.10 10.42 6 236627 24 64262075
Bone marrow granuloma 18.10 10.42 6 236627 24 64262075
Nocardia sepsis 18.10 10.42 6 236627 24 64262075
Focal myositis 18.10 10.42 6 236627 24 64262075
Avian influenza 18.09 10.42 8 236625 79 64262020
Neutrophil morphology abnormal 18.09 10.42 8 236625 79 64262020
Blood creatinine abnormal 18.08 10.42 44 236589 4083 64258016
Lung infiltration 18.08 10.42 135 236498 20754 64241345
Bone erosion 18.06 10.42 10 236623 11585 64250514
Hypertrophic cardiomyopathy 18.06 10.42 28 236605 1858 64260241
Sciatica 18.05 10.42 29 236604 20235 64241864
Sleep apnoea syndrome 18.02 10.42 53 236580 29779 64232320
Mental impairment 18.00 10.42 20 236613 16323 64245776
Sleep disorder due to general medical condition, insomnia type 18.00 10.42 161 236472 26109 64235990
Hair follicle tumour benign 18.00 10.42 14 236619 421 64261678
Renal arteritis 17.94 10.42 5 236628 9 64262090
Pleomorphism 17.94 10.42 5 236628 9 64262090
Coombs positive haemolytic anaemia 17.94 10.42 19 236614 859 64261240
Plasmapheresis 17.94 10.42 16 236617 584 64261515
Eye irritation 17.92 10.42 19 236614 15837 64246262
Cutaneous mucormycosis 17.92 10.42 9 236624 121 64261978
Transitional cell carcinoma metastatic 17.91 10.42 6 236627 25 64262074
Cyst 17.85 10.42 11 236622 12016 64250083
Prostatic specific antigen increased 17.84 10.42 5 236628 8755 64253344
Lung abscess 17.79 10.42 40 236593 3526 64258573
Dystonia 17.76 10.42 26 236607 18839 64243260
Joint dislocation 17.70 10.42 10 236623 11455 64250644
Renal tubular dysfunction 17.70 10.42 17 236616 683 64261416
Colitis microscopic 17.65 10.42 3 236630 7429 64254670
Moraxella infection 17.64 10.42 15 236618 513 64261586
Pneumonia aspiration 17.64 10.42 136 236497 59135 64202964
Seroma 17.62 10.42 29 236604 2025 64260074
Arteriovenous fistula thrombosis 17.62 10.42 15 236618 514 64261585
Complications of intestinal transplant 17.60 10.42 5 236628 10 64262089
Norovirus test positive 17.55 10.42 14 236619 437 64261662
Sneezing 17.54 10.42 18 236615 15233 64246866
Small cell carcinoma 17.48 10.42 12 236621 296 64261803
Rash macular 17.47 10.42 38 236595 23647 64238452
C-reactive protein increased 17.46 10.42 244 236389 94665 64167434
Tooth abscess 17.45 10.42 15 236618 13811 64248288
Ageusia 17.42 10.42 15 236618 13798 64248301
Meningoencephalitis bacterial 17.38 10.42 10 236623 179 64261920
Upper respiratory tract inflammation 17.30 10.42 41 236592 3741 64258358
Faecaloma 17.29 10.42 7 236626 9721 64252378
Sinusitis fungal 17.29 10.42 26 236607 1680 64260419
Transmission of an infectious agent via transplant 17.28 10.42 5 236628 11 64262088
Renal cyst haemorrhage 17.26 10.42 14 236619 448 64261651
Rash erythematous 17.24 10.42 106 236527 48527 64213572
Stomatococcal infection 17.21 10.42 11 236622 240 64261859
Eosinophilic oesophagitis 17.20 10.42 14 236619 450 64261649
Fibrosis 17.20 10.42 47 236586 4681 64257418
Acid base balance abnormal 17.17 10.42 12 236621 305 64261794
Subcutaneous emphysema 16.99 10.42 25 236608 1584 64260515
Acute allograft nephropathy 16.98 10.42 5 236628 12 64262087
Herpes simplex viraemia 16.97 10.42 11 236622 246 64261853
Vaginal haemorrhage 16.93 10.42 28 236605 19316 64242783
Viral diarrhoea 16.89 10.42 11 236622 248 64261851
Asphyxia 16.81 10.42 7 236626 9559 64252540
Skin abrasion 16.80 10.42 11 236622 11634 64250465
Anastomotic complication 16.80 10.42 13 236620 388 64261711
Diarrhoea infectious 16.80 10.42 23 236610 1363 64260736
Pericardial fibrosis 16.79 10.42 7 236626 59 64262040
Myocarditis toxoplasmal 16.79 10.42 7 236626 59 64262040
Herpes simplex oesophagitis 16.77 10.42 11 236622 251 64261848
Scleroderma renal crisis 16.77 10.42 13 236620 389 64261710
Oral discomfort 16.74 10.42 5 236628 8401 64253698
Bone tuberculosis 16.74 10.42 14 236619 468 64261631
Muscle tightness 16.73 10.42 10 236623 11105 64250994
Retroperitoneal lymphadenopathy 16.64 10.42 19 236614 935 64261164
Blood culture positive 16.63 10.42 65 236568 7803 64254296
Incoherent 16.62 10.42 3 236630 7115 64254984
Intentional product use issue 16.61 10.42 463 236170 94901 64167198
Herpes simplex meningoencephalitis 16.59 10.42 7 236626 61 64262038
Severe acute respiratory syndrome 16.58 10.42 8 236625 98 64262001
Respiratory rate increased 16.55 10.42 26 236607 18305 64243794
Pyuria 16.50 10.42 28 236605 2005 64260094
Renal injury 16.49 10.42 105 236528 15324 64246775
Night sweats 16.48 10.42 72 236561 35974 64226125
Giardiasis 16.47 10.42 11 236622 259 64261840
Obstructive airways disorder 16.45 10.42 38 236595 23147 64238952
Oral papilloma 16.43 10.42 5 236628 14 64262085
Cerebral cyst 16.41 10.42 12 236621 328 64261771
Anorectal varices 16.41 10.42 6 236627 34 64262065
Diffuse large B-cell lymphoma stage IV 16.41 10.42 14 236619 481 64261618
Bradyphrenia 16.34 10.42 7 236626 9399 64252700
Nephrectomy 16.34 10.42 23 236610 1399 64260700
Secretion discharge 16.33 10.42 12 236621 11952 64250147
Decubitus ulcer 16.31 10.42 15 236618 13364 64248735
Anal incontinence 16.30 10.42 19 236614 15177 64246922
Page kidney 16.30 10.42 7 236626 64 64262035
Procedural pneumothorax 16.30 10.42 7 236626 64 64262035
Hydrocephalus 16.28 10.42 63 236570 7528 64254571
Fat necrosis 16.24 10.42 17 236616 758 64261341
Skin necrosis 16.24 10.42 99 236534 14230 64247869
Tuberculosis of central nervous system 16.24 10.42 13 236620 408 64261691
Pneumonia respiratory syncytial viral 16.23 10.42 23 236610 1408 64260691
Intracranial infection 16.22 10.42 4 236629 3 64262096
SARS-CoV-2 viraemia 16.22 10.42 4 236629 3 64262096
Disseminated varicella 16.22 10.42 4 236629 3 64262096
Solid organ transplant rejection 16.22 10.42 4 236629 3 64262096
Enterocolitis fungal 16.22 10.42 4 236629 3 64262096
Squamous cell carcinoma of the vulva 16.22 10.42 4 236629 3 64262096
Ankylosing spondylitis 16.22 10.42 5 236628 8229 64253870
Hyperparathyroidism secondary 16.21 10.42 30 236603 2300 64259799
Hyperthyroidism 16.21 10.42 26 236607 18153 64243946
HIV infection 16.20 10.42 19 236614 963 64261136
Spontaneous intrahepatic portosystemic venous shunt 16.18 10.42 5 236628 15 64262084
Haemorrhage intracranial 16.17 10.42 146 236487 23738 64238361
Productive cough 16.16 10.42 181 236452 73022 64189077
Gestational hypertension 16.16 10.42 25 236608 1656 64260443
Groin pain 16.12 10.42 11 236622 11382 64250717
Orbital apex syndrome 16.11 10.42 7 236626 66 64262033
Henoch-Schonlein purpura 16.11 10.42 29 236604 2177 64259922
Vascular pseudoaneurysm ruptured 16.05 10.42 9 236624 153 64261946
Large intestine infection 16.03 10.42 32 236601 2596 64259503
Optic discs blurred 16.02 10.42 7 236626 67 64262032
Joint range of motion decreased 16.02 10.42 29 236604 19314 64242785
Cholecystitis chronic 16.00 10.42 7 236626 9280 64252819
Renal haemorrhage 15.96 10.42 27 236606 1928 64260171
Tropical spastic paresis 15.94 10.42 5 236628 16 64262083
Rash maculo-papular 15.90 10.42 104 236529 46922 64215177
Electrocardiogram QRS complex prolonged 15.87 10.42 7 236626 9237 64252862
Coinfection 15.85 10.42 6 236627 38 64262061
Sarcoma metastatic 15.84 10.42 7 236626 69 64262030
Thrombocytopenia 15.80 10.42 987 235646 222814 64039285
Myelosuppression 15.79 10.42 145 236488 23685 64238414
Transfusion 15.79 10.42 26 236607 17968 64244131
Eructation 15.72 10.42 7 236626 9184 64252915
Seasonal allergy 15.70 10.42 12 236621 11714 64250385
Uraemic encephalopathy 15.70 10.42 14 236619 511 64261588
Myocarditis mycotic 15.69 10.42 4 236629 4 64262095
Extranodal marginal zone B-cell lymphoma (MALT type) stage IV 15.69 10.42 4 236629 4 64262095
Fascioliasis 15.69 10.42 4 236629 4 64262095
Insulin resistant diabetes 15.69 10.42 4 236629 4 64262095
Biliary obstruction 15.67 10.42 40 236593 3824 64258275
Laryngeal mass 15.67 10.42 7 236626 71 64262028
Oedema 15.64 10.42 240 236393 91695 64170404
Steatohepatitis 15.60 10.42 17 236616 794 64261305
Renal cell carcinoma stage I 15.60 10.42 6 236627 40 64262059
Post streptococcal glomerulonephritis 15.60 10.42 6 236627 40 64262059
Pulmonary cavitation 15.57 10.42 22 236611 1343 64260756
Blindness cortical 15.57 10.42 17 236616 796 64261303
Vena cava injury 15.57 10.42 10 236623 220 64261879
Glomerulonephritis acute 15.55 10.42 9 236624 163 64261936
Portal vein stenosis 15.49 10.42 5 236628 18 64262081
Gingival bleeding 15.48 10.42 19 236614 14835 64247264
Keratoacanthoma 15.47 10.42 18 236615 904 64261195
Gastroenteritis eosinophilic 15.41 10.42 10 236623 224 64261875
Electrocardiogram abnormal 15.41 10.42 16 236617 13465 64248634
Palatal ulcer 15.39 10.42 8 236625 116 64261983
Blood parathyroid hormone decreased 15.38 10.42 4 236629 7362 64254737
Haemophilus infection 15.35 10.42 26 236607 1859 64260240
Typhoid fever 15.35 10.42 6 236627 42 64262057
Arthropod bite 15.34 10.42 3 236630 6718 64255381
Lung adenocarcinoma stage IV 15.33 10.42 10 236623 226 64261873
Arteritis 15.31 10.42 16 236617 712 64261387
Peritoneal candidiasis 15.28 10.42 5 236628 19 64262080
Corynebacterium bacteraemia 15.28 10.42 5 236628 19 64262080
Leuconostoc infection 15.28 10.42 5 236628 19 64262080
Splenic peliosis 15.28 10.42 5 236628 19 64262080
Familial mediterranean fever 15.25 10.42 7 236626 76 64262023
Mental status changes 15.25 10.42 312 236321 60850 64201249
Splenic haemorrhage 15.21 10.42 15 236618 623 64261476
Pneumonia legionella 15.18 10.42 30 236603 2416 64259683
Asteatosis 15.17 10.42 7 236626 77 64262022
Lymphorrhoea 15.15 10.42 8 236625 120 64261979
Upper motor neurone lesion 15.14 10.42 10 236623 231 64261868
Wound complication 15.12 10.42 40 236593 3908 64258191
Herpes simplex pneumonia 15.11 10.42 6 236627 44 64262055
Pulmonary thrombosis 15.09 10.42 10 236623 10508 64251591
Pseudallescheria infection 15.08 10.42 5 236628 20 64262079
Myelodysplastic syndrome unclassifiable 15.08 10.42 5 236628 20 64262079
Pancreatic abscess 15.01 10.42 7 236626 79 64262020
Anti-GAD antibody positive 14.99 10.42 6 236627 45 64262054
Squamous cell carcinoma of the oral cavity 14.96 10.42 13 236620 458 64261641
Ear pain 14.94 10.42 45 236588 25091 64237008
Parvovirus B19 test positive 14.92 10.42 8 236625 124 64261975
Bowen's disease 14.92 10.42 8 236625 124 64261975
Device related infection 14.91 10.42 175 236458 30451 64231648
Taste disorder 14.89 10.42 8 236625 9425 64252674
Granulocytopenia 14.88 10.42 10 236623 10430 64251669
Cytomegalovirus duodenitis 14.86 10.42 7 236626 81 64262018
SARS-CoV-2 antibody test positive 14.84 10.42 10 236623 239 64261860
Treatment failure 14.82 10.42 321 236312 116495 64145604
Non-cirrhotic portal hypertension 14.82 10.42 12 236621 383 64261716
Bronchitis fungal 14.80 10.42 4 236629 6 64262093
Fracture 14.76 10.42 29 236604 18726 64243373
Hepatitis infectious mononucleosis 14.75 10.42 8 236625 127 64261972
Cachexia 14.75 10.42 70 236563 9147 64252952
Tenosynovitis 14.74 10.42 13 236620 11820 64250279
Cytotoxic oedema 14.73 10.42 11 236622 311 64261788
Fungal test positive 14.72 10.42 18 236615 953 64261146
Mucinous adenocarcinoma of appendix 14.71 10.42 5 236628 22 64262077
Beta 2 microglobulin urine increased 14.70 10.42 8 236625 128 64261971
Bursitis infective 14.67 10.42 20 236613 1180 64260919
Ligament sprain 14.67 10.42 11 236622 10841 64251258
Myocarditis infectious 14.66 10.42 6 236627 48 64262051
Weight fluctuation 14.65 10.42 6 236627 8276 64253823
Platelet count increased 14.63 10.42 29 236604 18667 64243432
Papilloedema 14.63 10.42 49 236584 5456 64256643
Haemorrhagic pneumonia 14.59 10.42 8 236625 130 64261969
Epstein-Barr virus antigen positive 14.56 10.42 7 236626 85 64262014
Eosinophilia 14.56 10.42 81 236552 37995 64224104
CSF culture positive 14.56 10.42 6 236627 49 64262050
Brown-Sequard syndrome 14.56 10.42 6 236627 49 64262050
Papillary renal cell carcinoma 14.53 10.42 8 236625 131 64261968
Morphoea 14.53 10.42 12 236621 394 64261705
Sphincter of Oddi dysfunction 14.50 10.42 12 236621 395 64261704
Transplant 14.50 10.42 17 236616 861 64261238
Precursor T-lymphoblastic lymphoma/leukaemia 14.49 10.42 7 236626 86 64262013
Blood pressure abnormal 14.49 10.42 19 236614 14416 64247683
Metapneumovirus infection 14.43 10.42 22 236611 1439 64260660
Vestibular nystagmus 14.43 10.42 4 236629 7 64262092
Endocarditis viral 14.43 10.42 4 236629 7 64262092
St. Louis encephalitis 14.43 10.42 4 236629 7 64262092
Skin plaque 14.38 10.42 68 236565 8872 64253227
Food interaction 14.37 10.42 22 236611 1444 64260655
Hospice care 14.37 10.42 5 236628 7620 64254479
Necrotising fasciitis fungal 14.36 10.42 5 236628 24 64262075
Foot fracture 14.35 10.42 28 236605 18129 64243970
Diffuse large B-cell lymphoma stage III 14.35 10.42 7 236626 88 64262011
Transient acantholytic dermatosis 14.35 10.42 7 236626 88 64262011
Haemoperitoneum 14.32 10.42 39 236594 3876 64258223
Arm amputation 14.32 10.42 8 236625 135 64261964
Colon dysplasia 14.32 10.42 8 236625 135 64261964
Portal fibrosis 14.30 10.42 14 236619 576 64261523
Renal hypertension 14.30 10.42 9 236624 191 64261908
Haemosiderosis 14.27 10.42 12 236621 404 64261695
Metastases to abdominal cavity 14.27 10.42 13 236620 488 64261611
Venous haemorrhage 14.25 10.42 10 236623 256 64261843
Bronchopneumopathy 14.24 10.42 14 236619 579 64261520
Blood loss anaemia 14.24 10.42 18 236615 13874 64248225
Coronary artery occlusion 14.23 10.42 18 236615 13873 64248226
Otitis media 14.22 10.42 48 236585 5365 64256734
Skin irritation 14.22 10.42 8 236625 9186 64252913
Coagulation test abnormal 14.22 10.42 19 236614 1100 64260999
Shock 14.21 10.42 208 236425 38032 64224067
Flavobacterium infection 14.21 10.42 7 236626 90 64262009
Hemianopia heteronymous 14.21 10.42 7 236626 90 64262009
Incontinence 14.19 10.42 14 236619 12067 64250032
Hypertensive encephalopathy 14.16 10.42 17 236616 883 64261216
Subdural haematoma 14.10 10.42 54 236579 28000 64234099
Feeling jittery 14.09 10.42 11 236622 10624 64251475
Parapox virus infection 14.08 10.42 4 236629 8 64262091
Viral uveitis 14.07 10.42 7 236626 92 64262007
Cytomegalovirus gastrointestinal ulcer 14.05 10.42 6 236627 54 64262045
Product prescribing error 14.05 10.42 74 236559 35195 64226904
Arteriosclerosis coronary artery 14.04 10.42 22 236611 15507 64246592
Aortic rupture 14.01 10.42 9 236624 198 64261901
Artery dissection 13.89 10.42 9 236624 201 64261898
Respiratory tract infection viral 13.89 10.42 30 236603 2573 64259526
Ventricular extrasystoles 13.88 10.42 27 236606 17502 64244597
B-lymphocyte abnormalities 13.88 10.42 5 236628 27 64262072
Disseminated coccidioidomycosis 13.86 10.42 6 236627 56 64262043
Toxocariasis 13.84 10.42 3 236630 0 64262099
Burkitt's leukaemia 13.84 10.42 3 236630 0 64262099
Oropharyngeal lymphoid hyperplasia 13.84 10.42 3 236630 0 64262099
Pulmonary sensitisation 13.84 10.42 3 236630 0 64262099
Visual agnosia 13.84 10.42 3 236630 0 64262099
Cytomegalovirus urinary tract infection 13.84 10.42 3 236630 0 64262099
High grade B-cell lymphoma Burkitt-like lymphoma stage IV 13.84 10.42 3 236630 0 64262099
Pneumonia proteus 13.84 10.42 3 236630 0 64262099
West Nile virus test positive 13.84 10.42 3 236630 0 64262099
Retroperitoneal effusion 13.84 10.42 3 236630 0 64262099
Microtia 13.84 10.42 3 236630 0 64262099
Disseminated paracoccidioidomycosis 13.84 10.42 3 236630 0 64262099
Thirst 13.79 10.42 19 236614 14118 64247981
Neurofibrosarcoma 13.78 10.42 9 236624 204 64261895
Diverticulitis 13.78 10.42 84 236549 38534 64223565
Purulent pericarditis 13.77 10.42 6 236627 57 64262042
Drug level 13.77 10.42 4 236629 9 64262090
Parotid abscess 13.77 10.42 4 236629 9 64262090
Hepatic echinococciasis 13.77 10.42 4 236629 9 64262090
Tuberculosis of genitourinary system 13.73 10.42 5 236628 28 64262071
Hepatobiliary infection 13.73 10.42 5 236628 28 64262071
Pulmonary sepsis 13.70 10.42 33 236600 3042 64259057
Retinal ischaemia 13.69 10.42 15 236618 705 64261394
Haemothorax 13.67 10.42 44 236589 4798 64257301
B-lymphocyte count decreased 13.67 10.42 19 236614 1142 64260957
Concussion 13.65 10.42 6 236627 7932 64254167
Human herpes virus 6 serology positive 13.62 10.42 9 236624 208 64261891
Splenic necrosis 13.62 10.42 7 236626 99 64262000
Pharyngeal abscess 13.60 10.42 14 236619 612 64261487
Contraindicated product prescribed 13.60 10.42 19 236614 1148 64260951
Biopsy liver abnormal 13.59 10.42 12 236621 432 64261667
Drug trough level 13.58 10.42 5 236628 29 64262070
Plasma cell myeloma 13.58 10.42 106 236527 45969 64216130
Pelvic pain 13.57 10.42 12 236621 10898 64251201
Mucosal necrosis 13.56 10.42 7 236626 100 64261999
Resting tremor 13.55 10.42 21 236612 1393 64260706
Fanconi syndrome 13.55 10.42 29 236604 2472 64259627
Actinomycosis 13.54 10.42 17 236616 925 64261174
Retching 13.43 10.42 22 236611 15234 64246865
Multi-organ disorder 13.39 10.42 27 236606 2206 64259893
Product administration error 13.39 10.42 54 236579 27589 64234510
Generalised tonic-clonic seizure 13.35 10.42 213 236420 39644 64222455
Leukaemic infiltration extramedullary 13.35 10.42 8 236625 155 64261944
Lung squamous cell carcinoma stage IV 13.33 10.42 6 236627 62 64262037
Splenic infection fungal 13.32 10.42 7 236626 104 64261995
Circulatory collapse 13.31 10.42 71 236562 33661 64228438
T-cell type acute leukaemia 13.30 10.42 8 236625 156 64261943
Cardiac index increased 13.30 10.42 5 236628 31 64262068
Endocarditis staphylococcal 13.29 10.42 14 236619 629 64261470
Abdominal abscess 13.26 10.42 52 236581 6252 64255847
Arteriovenous fistula occlusion 13.26 10.42 13 236620 536 64261563
Splinter haemorrhages 13.25 10.42 6 236627 63 64262036
Hepatic infection 13.24 10.42 16 236617 837 64261262
Picornavirus infection 13.20 10.42 4 236629 11 64262088
Hepatic angiosarcoma 13.20 10.42 4 236629 11 64262088
Oesophageal tuberculosis 13.20 10.42 4 236629 11 64262088
Acute disseminated encephalomyelitis 13.17 10.42 10 236623 290 64261809
Hirsutism 13.10 10.42 17 236616 956 64261143
Deafness 13.10 10.42 30 236603 18329 64243770
Systemic inflammatory response syndrome 13.08 10.42 73 236560 10162 64251937
Immobile 13.08 10.42 3 236630 6012 64256087
Herpes zoster oticus 13.04 10.42 11 236622 372 64261727
Diffuse mesangial sclerosis 13.04 10.42 5 236628 33 64262066
Mean cell haemoglobin concentration 13.04 10.42 5 236628 33 64262066
Type 3 diabetes mellitus 13.04 10.42 5 236628 33 64262066
Dizziness postural 13.03 10.42 10 236623 9742 64252357
Pneumonia mycoplasmal 13.03 10.42 20 236613 1316 64260783
Increased tendency to bruise 13.01 10.42 9 236624 9246 64252853
Hypergammaglobulinaemia 13.01 10.42 14 236619 645 64261454
Narrow anterior chamber angle 12.95 10.42 8 236625 164 64261935
Argentine haemorrhagic fever 12.95 10.42 4 236629 12 64262087
Dermatitis papillaris capillitii 12.95 10.42 4 236629 12 64262087
Salmonellosis 12.94 10.42 20 236613 1324 64260775
Haematocrit decreased 12.92 10.42 133 236500 54522 64207577
Septal panniculitis 12.92 10.42 6 236627 67 64262032
Salmonella bacteraemia 12.91 10.42 10 236623 299 64261800
Adenocarcinoma 12.88 10.42 34 236599 3317 64258782
Scopulariopsis infection 12.86 10.42 7 236626 112 64261987
Tracheobronchitis 12.85 10.42 23 236610 1719 64260380
Chronic graft versus host disease in eye 12.85 10.42 6 236627 68 64262031
Adrenal mass 12.78 10.42 17 236616 980 64261119
Meningitis listeria 12.74 10.42 15 236618 763 64261336
Papilloma 12.74 10.42 10 236623 305 64261794
Bronchopulmonary disease 12.71 10.42 4 236629 13 64262086
Herpes sepsis 12.71 10.42 4 236629 13 64262086
Acute myeloid leukaemia (in remission) 12.71 10.42 4 236629 13 64262086
Mesangioproliferative glomerulonephritis 12.69 10.42 6 236627 70 64262029
Radiculitis brachial 12.69 10.42 6 236627 70 64262029
Breast pain 12.68 10.42 5 236628 7056 64255043
Tooth extraction 12.63 10.42 10 236623 9591 64252508
Varicella virus test positive 12.62 10.42 8 236625 172 64261927
Laryngeal cancer 12.61 10.42 14 236619 668 64261431
Ophthalmic herpes simplex 12.58 10.42 13 236620 571 64261528
Gastroenteritis rotavirus 12.58 10.42 11 236622 391 64261708
Multimorbidity 12.58 10.42 17 236616 995 64261104
Diabetic ketoacidosis 12.58 10.42 166 236467 29679 64232420
Pseudopolyp 12.55 10.42 11 236622 392 64261707
Necrotising herpetic retinopathy 12.54 10.42 7 236626 118 64261981
Eyelid oedema 12.49 10.42 16 236617 12263 64249836
Acanthosis 12.48 10.42 11 236622 395 64261704
Tonsillar neoplasm 12.48 10.42 4 236629 14 64262085
Hypoplastic anaemia 12.48 10.42 4 236629 14 64262085
Small intestine gangrene 12.48 10.42 4 236629 14 64262085
Unmasking of previously unidentified disease 12.47 10.42 22 236611 1625 64260474
Hypertriglyceridaemia 12.44 10.42 77 236556 11128 64250971
Cerebrovascular insufficiency 12.43 10.42 7 236626 120 64261979
Glomerulonephritis minimal lesion 12.43 10.42 14 236619 679 64261420
Osteomyelitis chronic 12.40 10.42 13 236620 581 64261518
Sinusitis bacterial 12.33 10.42 18 236615 1132 64260967
Wound evisceration 12.33 10.42 7 236626 122 64261977
Leiomyoma 12.33 10.42 10 236623 320 64261779
Left ventricular hypertrophy 12.28 10.42 68 236565 9438 64252661
Haemorrhagic ovarian cyst 12.27 10.42 12 236621 493 64261606
Oesophageal squamous cell carcinoma stage IV 12.27 10.42 4 236629 15 64262084
Cytomegalovirus myocarditis 12.27 10.42 4 236629 15 64262084
Lipids abnormal 12.25 10.42 12 236621 494 64261605
Glaucoma 12.25 10.42 26 236607 16322 64245777
Renal tuberculosis 12.22 10.42 5 236628 40 64262059
Hepatic infarction 12.20 10.42 15 236618 799 64261300
Drug ineffective 12.19 10.42 3359 233274 836888 63425211
Dyspnoea at rest 12.19 10.42 4 236629 6325 64255774
Nephrolithiasis 12.18 10.42 102 236531 43581 64218518
Erosive duodenitis 12.18 10.42 22 236611 1656 64260443
Pancreatic pseudoaneurysm 12.12 10.42 6 236627 78 64262021
Macular degeneration 12.12 10.42 3 236630 5707 64256392
Cord blood transplant therapy 12.11 10.42 5 236628 41 64262058
Lymphoid tissue hyperplasia 12.06 10.42 9 236624 254 64261845
Glomerular vascular disorder 12.04 10.42 7 236626 128 64261971
Infusion site extravasation 12.02 10.42 5 236628 6832 64255267
Bronchiectasis 12.02 10.42 91 236542 14049 64248050
Growth retardation 12.01 10.42 21 236612 1540 64260559
Haematoma infection 12.00 10.42 19 236614 1284 64260815
Renal cyst infection 11.99 10.42 8 236625 188 64261911
Therapeutic response unexpected 11.95 10.42 28 236605 16973 64245126
Tooth loss 11.94 10.42 4 236629 6243 64255856
Peritoneal dialysis 11.93 10.42 14 236619 710 64261389
Segmented hyalinising vasculitis 11.92 10.42 6 236627 81 64262018
Lymphangitis 11.91 10.42 19 236614 1292 64260807
Wound abscess 11.91 10.42 9 236624 259 64261840
Serum ferritin increased 11.91 10.42 62 236571 8406 64253693
Ureteric obstruction 11.89 10.42 27 236606 2395 64259704
Dry throat 11.89 10.42 4 236629 6228 64255871
Hypoaesthesia oral 11.87 10.42 15 236618 11565 64250534
Osteoporosis 11.85 10.42 98 236535 41982 64220117
Leishmaniasis 11.84 10.42 10 236623 339 64261760
Splenic neoplasm malignancy unspecified 11.81 10.42 5 236628 44 64262055
Eye infection 11.80 10.42 10 236623 9271 64252828
Hypersplenism 11.79 10.42 11 236622 426 64261673
Thrombasthenia 11.77 10.42 3 236630 3 64262096
Panel-reactive antibody increased 11.77 10.42 3 236630 3 64262096
Aortic injury 11.77 10.42 3 236630 3 64262096
Endocrine pancreatic disorder 11.77 10.42 3 236630 3 64262096
Biliary anastomosis 11.77 10.42 3 236630 3 64262096
Sialocele 11.77 10.42 3 236630 3 64262096
Epstein-Barr virus test negative 11.77 10.42 3 236630 3 64262096
Exserohilum infection 11.77 10.42 3 236630 3 64262096
Removal of transplanted organ 11.77 10.42 3 236630 3 64262096
Brachyspira infection 11.77 10.42 3 236630 3 64262096
Germ cell cancer metastatic 11.77 10.42 3 236630 3 64262096
Eccrine carcinoma 11.77 10.42 3 236630 3 64262096
Granulicatella bacteraemia 11.77 10.42 3 236630 3 64262096
Aeromonas test positive 11.77 10.42 3 236630 3 64262096
Neurological infection 11.77 10.42 3 236630 3 64262096
Hereditary neuropathic amyloidosis 11.77 10.42 3 236630 3 64262096
Iliac artery rupture 11.77 10.42 3 236630 3 64262096
Acute lymphocytic leukaemia recurrent 11.75 10.42 37 236596 3989 64258110
Hepatic artery occlusion 11.73 10.42 6 236627 84 64262015
Gonococcal infection 11.71 10.42 5 236628 45 64262054
Hypoproteinaemia 11.69 10.42 33 236600 3349 64258750
Sensory disturbance 11.67 10.42 19 236614 13189 64248910
Drug-induced liver injury 11.65 10.42 115 236518 47528 64214571
Embolic stroke 11.65 10.42 5 236628 6706 64255393
Delirium 11.64 10.42 181 236452 69013 64193086
Q fever 11.63 10.42 8 236625 198 64261901
Seroconversion test positive 11.62 10.42 5 236628 46 64262053
Rhegmatogenous retinal detachment 11.57 10.42 7 236626 138 64261961
Disorientation 11.56 10.42 140 236493 55688 64206411
Myopathy toxic 11.53 10.42 15 236618 846 64261253
Visual evoked potentials abnormal 11.52 10.42 5 236628 47 64262052
Infective aortitis 11.52 10.42 5 236628 47 64262052
Blood urine present 11.51 10.42 32 236601 18308 64243791
Synovial cyst 11.50 10.42 7 236626 7700 64254399
Lentigo 11.47 10.42 11 236622 441 64261658
Ventricular tachycardia 11.47 10.42 76 236557 34189 64227910
Pulmonary hypertension 11.47 10.42 102 236531 43037 64219062
Vasogenic cerebral oedema 11.45 10.42 16 236617 967 64261132
Pharyngitis streptococcal 11.44 10.42 9 236624 8659 64253440
Infective keratitis 11.43 10.42 5 236628 48 64262051
Pyonephrosis 11.42 10.42 6 236627 89 64262010
Psychotic disorder 11.42 10.42 77 236556 34501 64227598
Chronic myeloid leukaemia recurrent 11.39 10.42 9 236624 277 64261822
Renal amyloidosis 11.35 10.42 7 236626 143 64261956
Small cell lung cancer recurrent 11.35 10.42 4 236629 20 64262079
Hyperaesthesia 11.31 10.42 12 236621 10002 64252097
Pelvic venous thrombosis 11.31 10.42 22 236611 1751 64260348
Multiple fractures 11.31 10.42 4 236629 6036 64256063
Mycobacterium kansasii infection 11.31 10.42 9 236624 280 64261819
Vascular graft thrombosis 11.29 10.42 8 236625 208 64261891
Ureteritis 11.25 10.42 6 236627 92 64262007
T-lymphocyte count abnormal 11.19 10.42 4 236629 21 64262078
Urogenital infection bacterial 11.19 10.42 6 236627 93 64262006
Heart transplant 11.19 10.42 18 236615 1233 64260866
Abdominal lymphadenopathy 11.18 10.42 17 236616 1109 64260990
Oropharyngeal candidiasis 11.17 10.42 20 236613 1495 64260604
Encephalitis Japanese B 11.17 10.42 5 236628 51 64262048
Blood pressure ambulatory increased 11.17 10.42 5 236628 51 64262048
Cardiac autonomic neuropathy 11.17 10.42 5 236628 51 64262048
Tongue oedema 11.16 10.42 4 236629 5986 64256113
Parotitis 11.15 10.42 25 236608 2200 64259899
Chest wall abscess 11.14 10.42 7 236626 148 64261951
Hypokinesia 11.14 10.42 28 236605 16568 64245531
Gastrointestinal pain 11.14 10.42 7 236626 7567 64254532
Blood calcium increased 11.11 10.42 9 236624 8533 64253566
Biopsy kidney 11.10 10.42 7 236626 149 64261950
Vulval ulceration 11.10 10.42 7 236626 149 64261950
Myeloma cast nephropathy 11.10 10.42 7 236626 149 64261950
Meningitis enterococcal 11.08 10.42 6 236627 95 64262004
Urinary tract infection fungal 11.07 10.42 15 236618 880 64261219
Gastric ulcer 11.06 10.42 164 236469 30070 64232029
Tonsillar exudate 11.04 10.42 4 236629 22 64262077
Brain death 10.97 10.42 41 236592 4820 64257279
Type III immune complex mediated reaction 10.95 10.42 12 236621 564 64261535
Campylobacter infection 10.95 10.42 18 236615 1256 64260843
Cushingoid 10.92 10.42 56 236577 7547 64254552
Gastrointestinal fungal infection 10.92 10.42 10 236623 378 64261721
Large cell lung cancer 10.89 10.42 4 236629 23 64262076
Increased insulin requirement 10.86 10.42 7 236626 155 64261944
Laparotomy 10.83 10.42 9 236624 298 64261801
T-lymphocyte count decreased 10.78 10.42 11 236622 476 64261623
Tracheomalacia 10.78 10.42 8 236625 224 64261875
Yersinia infection 10.75 10.42 4 236629 24 64262075
Ischaemic nephropathy 10.75 10.42 4 236629 24 64262075
Retinal scar 10.74 10.42 10 236623 386 64261713
Enterobacter bacteraemia 10.72 10.42 12 236621 578 64261521
Ventricular arrhythmia 10.70 10.42 7 236626 7408 64254691
Achromobacter infection 10.70 10.42 6 236627 102 64261997
Blast crisis in myelogenous leukaemia 10.68 10.42 14 236619 795 64261304
Gingival pain 10.65 10.42 5 236628 6362 64255737
Haemarthrosis 10.62 10.42 3 236630 5226 64256873
Hepatitis C RNA 10.61 10.42 4 236629 25 64262074
Corynebacterium sepsis 10.60 10.42 5 236628 58 64262041
Infusion site erythema 10.60 10.42 6 236627 6867 64255232
Eosinophilic colitis 10.59 10.42 10 236623 393 64261706
Inflammatory myofibroblastic tumour 10.59 10.42 7 236626 162 64261937
Periventricular leukomalacia 10.56 10.42 3 236630 6 64262093
Nasal vestibulitis 10.56 10.42 3 236630 6 64262093
Actinic cheilitis 10.56 10.42 3 236630 6 64262093
Cystitis glandularis 10.56 10.42 3 236630 6 64262093
Anaplastic large cell lymphoma T- and null-cell types stage III 10.56 10.42 3 236630 6 64262093
Endocarditis Q fever 10.56 10.42 3 236630 6 64262093
Giant cell myocarditis 10.56 10.42 3 236630 6 64262093
Erdheim-Chester disease 10.56 10.42 3 236630 6 64262093
Oesophagogastroscopy normal 10.56 10.42 3 236630 6 64262093
Urine abnormality 10.56 10.42 7 236626 7355 64254744
Metastases to central nervous system 10.53 10.42 22 236611 13890 64248209
Viral load abnormal 10.53 10.42 5 236628 59 64262040
Drug clearance decreased 10.51 10.42 27 236606 2592 64259507
Culture positive 10.50 10.42 16 236617 1046 64261053
Parvimonas micra infection 10.48 10.42 4 236629 26 64262073
Endotoxic shock 10.48 10.42 4 236629 26 64262073
Pneumothorax spontaneous 10.45 10.42 16 236617 1050 64261049

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D11AH01 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Agents for dermatitis, excluding corticosteroids
ATC L04AD02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Calcineurin inhibitors
FDA EPC N0000175457 Calcineurin Inhibitor Immunosuppressant
FDA MoA N0000175458 Calcineurin Inhibitors
CHEBI has role CHEBI:35705 immunosuppressive agents
MeSH PA D065095 Calcineurin Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Atopic dermatitis indication 24079001 DOID:3310
Transplanted organ rejection indication 213148006
Liver transplant rejection indication 235911006
Renal transplant rejection indication 236570004
Prevention of Cardiac Transplant Rejection indication
Prevention of Transplant Rejection indication
Prevention of Liver Transplant Rejection indication
Intractable Eczema indication
Prevention of Kidney Transplant Rejection indication
Prevention of Lung Transplant Rejection off-label use
Delirium contraindication 2776000
Herpes zoster contraindication 4740000 DOID:8536
Hyperkalemia contraindication 14140009
Progressive multifocal leukoencephalopathy contraindication 22255007 DOID:643
Constitutional aplastic anemia contraindication 28975000 DOID:1342
Lymphadenopathy contraindication 30746006
Torsades de pointes contraindication 31722008
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Mental handicap contraindication 47437004
Chronic heart failure contraindication 48447003
Left ventricular hypertrophy contraindication 55827005
Hepatic failure contraindication 59927004
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Herpes simplex contraindication 88594005 DOID:8566
Kidney disease contraindication 90708001 DOID:557
Prolonged QT interval contraindication 111975006
Malignant lymphoma contraindication 118600007 DOID:0060058
Seizure disorder contraindication 128613002
Eczema herpeticum contraindication 186535001 DOID:9123
Toxic nephropathy contraindication 236514003
Post-transplant lymphoproliferative disorder contraindication 254290004
Infectious mononucleosis contraindication 271558008 DOID:8568
Netherton's syndrome contraindication 312514006
Coma contraindication 371632003
Primary malignant neoplasm contraindication 372087000
Neuropathy contraindication 386033004 DOID:870
Breastfeeding (mother) contraindication 413712001
Congenital long QT syndrome contraindication 442917000
Posterior reversible encephalopathy syndrome contraindication 450886002
Tacrolimus Toxicity contraindication
Tremors contraindication
BK Polyomavirus Reactivation Nephropathy contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.4 acidic
pKa2 13.12 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10548880 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10548880 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8486993 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8586084 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8623411 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8889185 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8889186 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 9161907 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10548880 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10548880 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8486993 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8586084 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8623411 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8889185 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8889186 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 9161907 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10548880 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10548880 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8486993 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8586084 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8623411 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8889185 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8889186 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 9161907 Aug. 30, 2024 PROPHYLAXIS OF ORGAN REJECTION
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10864199 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10864199 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 11110081 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 11123331 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10864199 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10864199 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 11110081 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 11123331 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10864199 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 10864199 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 11110081 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 11123331 May 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8664239 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8664239 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8664239 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8685998 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8685998 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8685998 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8664239 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8664239 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8664239 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8685998 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8685998 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8685998 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8664239 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8664239 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8664239 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8685998 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8685998 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN DE NOVO TRANSPLANT PATIENT
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL 8685998 Aug. 30, 2028 PROPHYLAXIS OF ORGAN REJECTION IN PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 0.75MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL July 10, 2022 PROPHYLAXIS OF ORGAN REJECTION IN KIDNEY TRANSPLANT PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS IN COMBINATION WITH OTHER IMMUNOSUPPRESSANTS
EQ 1MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL July 10, 2022 PROPHYLAXIS OF ORGAN REJECTION IN KIDNEY TRANSPLANT PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS IN COMBINATION WITH OTHER IMMUNOSUPPRESSANTS
EQ 4MG BASE ENVARSUS XR VELOXIS PHARMS INC N206406 July 10, 2015 RX TABLET, EXTENDED RELEASE ORAL July 10, 2022 PROPHYLAXIS OF ORGAN REJECTION IN KIDNEY TRANSPLANT PATIENTS CONVERTED FROM TACROLIMUS IMMEDIATE-RELEASE FORMULATIONS IN COMBINATION WITH OTHER IMMUNOSUPPRESSANTS
EQ 0.5MG BASE PROGRAF ASTELLAS N050708 Aug. 24, 1998 RX CAPSULE ORAL May 24, 2025 PROPHYLAXIS OF ORGAN REJECTION IN PEDIATRIC PATIENTS RECEIVING ALLOGENEIC KIDNEY OR HEART TRANSPLANTS, IN COMBINATION WITH OTHER IMMUNOSUPPRESSANTS
EQ 1MG BASE PROGRAF ASTELLAS N050708 April 8, 1994 RX CAPSULE ORAL May 24, 2025 PROPHYLAXIS OF ORGAN REJECTION IN PEDIATRIC PATIENTS RECEIVING ALLOGENEIC KIDNEY OR HEART TRANSPLANTS, IN COMBINATION WITH OTHER IMMUNOSUPPRESSANTS
EQ 5MG BASE PROGRAF ASTELLAS N050708 April 8, 1994 RX CAPSULE ORAL May 24, 2025 PROPHYLAXIS OF ORGAN REJECTION IN PEDIATRIC PATIENTS RECEIVING ALLOGENEIC KIDNEY OR HEART TRANSPLANTS, IN COMBINATION WITH OTHER IMMUNOSUPPRESSANTS
EQ 5MG BASE/ML PROGRAF ASTELLAS N050709 April 8, 1994 RX INJECTABLE INJECTION May 24, 2025 PROPHYLAXIS OF ORGAN REJECTION IN PEDIATRIC PATIENTS RECEIVING ALLOGENEIC KIDNEY OR HEART TRANSPLANTS, IN COMBINATION WITH OTHER IMMUNOSUPPRESSANTS
EQ 0.5MG BASE ASTAGRAF XL ASTELLAS N204096 July 19, 2013 RX CAPSULE, EXTENDED RELEASE ORAL May 24, 2025 FDA HAS NOT RECOGNIZED ORPHAN-DRUG EXCLUSIVITY (ODE) FOR THIS DRUG, BUT IT CONTAINS THE SAME ACTIVE MOIETY OR MOIETIES AS ANOTHER DRUG(S) THAT WAS ELIGIBLE FOR ODE, AND ALSO SHARES ODE-PROTECTED USE(S) OR INDICATION(S) WITH THAT DRUG(S). AN APPLICATION SEEKING APPROVAL FOR THE SAME ACTIVE MOIETY OR MOIETIES, INCLUDING AN ANDA THAT CITES THIS NDA AS ITS BASIS OF SUBMISSION, MAY NOT BE APPROVED FOR SUCH ODE-PROTECTED USE(S) AND INDICATION(S)
EQ 1MG BASE ASTAGRAF XL ASTELLAS N204096 July 19, 2013 RX CAPSULE, EXTENDED RELEASE ORAL May 24, 2025 FDA HAS NOT RECOGNIZED ORPHAN-DRUG EXCLUSIVITY (ODE) FOR THIS DRUG, BUT IT CONTAINS THE SAME ACTIVE MOIETY OR MOIETIES AS ANOTHER DRUG(S) THAT WAS ELIGIBLE FOR ODE, AND ALSO SHARES ODE-PROTECTED USE(S) OR INDICATION(S) WITH THAT DRUG(S). AN APPLICATION SEEKING APPROVAL FOR THE SAME ACTIVE MOIETY OR MOIETIES, INCLUDING AN ANDA THAT CITES THIS NDA AS ITS BASIS OF SUBMISSION, MAY NOT BE APPROVED FOR SUCH ODE-PROTECTED USE(S) AND INDICATION(S)
EQ 5MG BASE ASTAGRAF XL ASTELLAS N204096 July 19, 2013 RX CAPSULE, EXTENDED RELEASE ORAL May 24, 2025 FDA HAS NOT RECOGNIZED ORPHAN-DRUG EXCLUSIVITY (ODE) FOR THIS DRUG, BUT IT CONTAINS THE SAME ACTIVE MOIETY OR MOIETIES AS ANOTHER DRUG(S) THAT WAS ELIGIBLE FOR ODE, AND ALSO SHARES ODE-PROTECTED USE(S) OR INDICATION(S) WITH THAT DRUG(S). AN APPLICATION SEEKING APPROVAL FOR THE SAME ACTIVE MOIETY OR MOIETIES, INCLUDING AN ANDA THAT CITES THIS NDA AS ITS BASIS OF SUBMISSION, MAY NOT BE APPROVED FOR SUCH ODE-PROTECTED USE(S) AND INDICATION(S)
EQ 0.2MG BASE/PACKET PROGRAF ASTELLAS N210115 May 24, 2018 RX FOR SUSPENSION ORAL May 24, 2025 PROPHYLAXIS OF ORGAN REJECTION IN PEDIATRIC PATIENTS RECEIVING ALLOGENEIC KIDNEY TRANSPLANT, LIVER TRANSPLANTS, AND HEART TRANSPLANT, IN COMBINATION WITH OTHER IMMUNOSUPPRESSANTS
EQ 1MG BASE/PACKET PROGRAF ASTELLAS N210115 May 24, 2018 RX FOR SUSPENSION ORAL May 24, 2025 PROPHYLAXIS OF ORGAN REJECTION IN PEDIATRIC PATIENTS RECEIVING ALLOGENEIC KIDNEY TRANSPLANT, LIVER TRANSPLANTS, AND HEART TRANSPLANT, IN COMBINATION WITH OTHER IMMUNOSUPPRESSANTS
EQ 0.5MG BASE PROGRAF ASTELLAS N050708 Aug. 24, 1998 RX CAPSULE ORAL July 16, 2028 FOR PROPHYLAXIS OF ORGAN REJECTION IN ADULT AND PEDIATRIC PATIENTS RECEIVING ALLOGENEIC LUNG TRANSPLANT
EQ 1MG BASE PROGRAF ASTELLAS N050708 April 8, 1994 RX CAPSULE ORAL July 16, 2028 FOR PROPHYLAXIS OF ORGAN REJECTION IN ADULT AND PEDIATRIC PATIENTS RECEIVING ALLOGENEIC LUNG TRANSPLANT
EQ 5MG BASE PROGRAF ASTELLAS N050708 April 8, 1994 RX CAPSULE ORAL July 16, 2028 FOR PROPHYLAXIS OF ORGAN REJECTION IN ADULT AND PEDIATRIC PATIENTS RECEIVING ALLOGENEIC LUNG TRANSPLANT
EQ 5MG BASE/ML PROGRAF ASTELLAS N050709 April 8, 1994 RX INJECTABLE INJECTION July 16, 2028 FOR PROPHYLAXIS OF ORGAN REJECTION IN ADULT AND PEDIATRIC PATIENTS RECEIVING ALLOGENEIC LUNG TRANSPLANT
EQ 0.2MG BASE/PACKET PROGRAF ASTELLAS N210115 May 24, 2018 RX FOR SUSPENSION ORAL July 16, 2028 FOR PROPHYLAXIS OF ORGAN REJECTION IN ADULT AND PEDIATRIC PATIENTS RECEIVING ALLOGENEIC LUNG TRANSPLANT
EQ 1MG BASE/PACKET PROGRAF ASTELLAS N210115 May 24, 2018 RX FOR SUSPENSION ORAL July 16, 2028 FOR PROPHYLAXIS OF ORGAN REJECTION IN ADULT AND PEDIATRIC PATIENTS RECEIVING ALLOGENEIC LUNG TRANSPLANT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Peptidyl-prolyl cis-trans isomerase FKBP1A Enzyme INHIBITOR Kd 9.40 WOMBAT-PK CHEMBL
Cytochrome P450 3A4 Enzyme IC50 6 DRUG MATRIX
Interleukin-5 Cytokine IC50 10.22 WOMBAT-PK
Interferon gamma Cytokine IC50 10.22 WOMBAT-PK
Interleukin-2 Cytokine IC50 9.72 WOMBAT-PK
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform Enzyme Ki 7.46 WOMBAT-PK
Serine/threonine-protein kinase mTOR Kinase IC50 9.02 CHEMBL
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Enzyme Kd 7.70 CHEMBL
Peptidyl-prolyl cis-trans isomerase FKBP1B Enzyme Kd 9.40 CHEMBL
Peptidyl-prolyl cis-trans isomerase FKBP5 Enzyme Ki 7.10 CHEMBL
Splicing factor 3B subunit 3 Nuclear other IC50 7.96 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6 WOMBAT-PK
Peptidyl-prolyl cis-trans isomerase FKBP10 Enzyme IC50 9.02 WOMBAT-PK

External reference:

IDSource
4020868 VUID
N0000148372 NUI
D00107 KEGG_DRUG
4020868 VANDF
C0085149 UMLSCUI
CHEBI:61049 CHEBI
CHEMBL269732 ChEMBL_ID
CHEMBL3989887 ChEMBL_ID
D016559 MESH_DESCRIPTOR_UI
DB00864 DRUGBANK_ID
6784 IUPHAR_LIGAND_ID
WM0HAQ4WNM UNII
445643 PUBCHEM_CID
235991 RXNORM
133309 MMSL
5539 MMSL
66434 MMSL
d03752 MMSL
004446 NDDF
004447 NDDF
109129008 SNOMEDCT_US
386975001 SNOMEDCT_US
6878 INN_ID
109581-93-3 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0168-0416 OINTMENT 1 mg TOPICAL ANDA 26 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0168-0417 OINTMENT 0.30 mg TOPICAL ANDA 26 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0378-2045 CAPSULE 0.50 mg ORAL ANDA 30 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0378-2045 CAPSULE 0.50 mg ORAL ANDA 30 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0378-2046 CAPSULE 1 mg ORAL ANDA 30 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0378-2046 CAPSULE 1 mg ORAL ANDA 30 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0378-2047 CAPSULE 5 mg ORAL ANDA 30 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0378-2047 CAPSULE 5 mg ORAL ANDA 30 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-0607 CAPSULE, GELATIN COATED 0.50 mg ORAL NDA 30 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-0617 CAPSULE, GELATIN COATED 1 mg ORAL NDA 30 sections
ASTAGRAF XL HUMAN PRESCRIPTION DRUG LABEL 1 0469-0647 CAPSULE, COATED, EXTENDED RELEASE 0.50 mg ORAL NDA 27 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-0657 CAPSULE, GELATIN COATED 5 mg ORAL NDA 30 sections
ASTAGRAF XL HUMAN PRESCRIPTION DRUG LABEL 1 0469-0677 CAPSULE, COATED, EXTENDED RELEASE 1 mg ORAL NDA 27 sections
ASTAGRAF XL HUMAN PRESCRIPTION DRUG LABEL 1 0469-0687 CAPSULE, COATED, EXTENDED RELEASE 5 mg ORAL NDA 27 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-1230 GRANULE, FOR SUSPENSION 0.20 mg ORAL NDA 30 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-1330 GRANULE, FOR SUSPENSION 1 mg ORAL NDA 30 sections
Prograf HUMAN PRESCRIPTION DRUG LABEL 1 0469-3016 INJECTION, SOLUTION 5 mg INTRAVENOUS NDA 30 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0781-2102 CAPSULE 0.50 mg ORAL ANDA 29 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0781-2103 CAPSULE 1 mg ORAL ANDA 29 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0781-2104 CAPSULE 5 mg ORAL ANDA 29 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0904-6425 CAPSULE 1 mg ORAL ANDA 26 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0904-6623 CAPSULE 0.50 mg ORAL ANDA 26 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0904-6624 CAPSULE 5 mg ORAL ANDA 26 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 0904-7097 CAPSULE 1 mg ORAL ANDA 26 sections
tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 16714-098 CAPSULE 0.50 mg ORAL ANDA 29 sections
tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 16714-099 CAPSULE 1 mg ORAL ANDA 29 sections
tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 16714-100 CAPSULE 5 mg ORAL ANDA 29 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 16729-041 CAPSULE 0.50 mg ORAL ANDA 30 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 16729-042 CAPSULE 1 mg ORAL ANDA 30 sections
Tacrolimus HUMAN PRESCRIPTION DRUG LABEL 1 16729-043 CAPSULE 5 mg ORAL ANDA 30 sections