All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

dupilumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
human origin	5224	1190264-60-8

Description:

Molecule

Description

Synonyms: dupilumab REGN668 SAR231893 dupixent

Dupilumab is a human monoclonal IgG4 antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling by specifically binding to the IL-4Rα subunit shared by the IL-4 and IL-13 receptor complexes. Dupilumab inhibits IL-4 signaling via the Type I receptor and both IL-4 and IL-13 signaling through the Type II receptor. Blocking IL-4Rα with dupilumab inhibits IL-4 and IL-13 cytokine-induced responses, including the release of proinflammatory cytokines, chemokines and IgE. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
21.40	mg	P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
July 3, 2017	EMA	sanofi-aventis groupe
Jan. 19, 2018	PMDA	Sanofi KK
March 28, 2017	FDA	REGENERON PHARMACEUTICALS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Injection site pain	33608.55	20.91	17291	493286	156408	89961462
Pruritus	31815.03	20.91	25323	485254	516202	89601668
Product use in unapproved indication	26134.38	20.91	18632	491945	317604	89800266
Dry skin	23622.30	20.91	10978	499599	77095	90040775
Eczema	22425.31	20.91	9110	501467	43760	90074110
Exposure via skin contact	14074.29	20.91	4288	506289	6417	90111453
Inappropriate schedule of product administration	11874.64	20.91	8434	502143	141499	89976371
Dry eye	11862.05	20.91	6012	504565	51919	90065951
Product dose omission in error	11567.47	20.91	4350	506227	16153	90101717
Skin exfoliation	11308.91	20.91	6137	504440	61776	90056094
Therapeutic response shortened	10804.81	20.91	4265	506312	18614	90099256
Product dose omission issue	10502.58	20.91	10397	500180	281290	89836580
Accidental exposure to product	10456.07	20.91	4995	505582	37371	90080499
Injection site swelling	10024.02	20.91	5430	505147	54409	90063461
Rash	9676.42	20.91	16541	494036	779559	89338311
Eye pruritus	9220.13	20.91	4079	506498	24948	90092922
Incorrect dose administered	8932.25	20.91	5551	505026	73379	90044491
Injection site erythema	8034.65	20.91	5647	504930	92855	90025015
Skin fissures	6982.20	20.91	3040	507537	17769	90100101
Skin burning sensation	6730.19	20.91	2911	507666	16700	90101170
Sleep disorder due to a general medical condition	5356.42	20.91	3264	507313	41474	90076396
Ocular hyperaemia	5230.66	20.91	2913	507664	30885	90086985
Rash erythematous	5010.65	20.91	3605	506972	61499	90056371
Eye irritation	4853.82	20.91	2779	507798	31199	90086671
Injection site pruritus	4576.03	20.91	3168	507409	50666	90067204
Therapeutic response decreased	4525.84	20.91	3871	506706	85858	90032012
Impaired quality of life	4330.31	20.91	2263	508314	20881	90096989
Rebound atopic dermatitis	4278.79	20.91	1118	509459	486	90117384
Injection site rash	4170.22	20.91	2239	508338	21934	90095936
Rebound eczema	4142.97	20.91	1029	509548	179	90117691
Injection site bruising	4050.72	20.91	2908	507669	49399	90068471
Injection site urticaria	3951.27	20.91	1961	508616	16050	90101820
Erythema	3911.45	20.91	5591	504986	223655	89894215
Condition aggravated	3711.87	20.91	9435	501142	586110	89531760
Product preparation error	3528.95	20.91	1526	509051	8735	90109135
Conjunctivitis	3411.46	20.91	2032	508545	24674	90093196
Rash macular	3176.30	20.91	2032	508545	28248	90089622
Skin haemorrhage	3150.43	20.91	1785	508792	19595	90098275
Skin swelling	3134.24	20.91	1237	509340	5377	90112493
Rebound effect	3078.63	20.91	1350	509227	8034	90109836
Illness	2695.44	20.91	2790	507787	79179	90038691
Skin weeping	2551.29	20.91	849	509728	1951	90115919
Vision blurred	2391.45	20.91	3026	507551	107267	90010603
COVID-19	2344.79	20.91	3744	506833	165099	89952771
Infusion related reaction	2210.24	20.91	26	510551	416754	89701116
Oral herpes	2084.84	20.91	1635	508942	31889	90085981
Drug intolerance	2079.08	20.91	108	510469	447483	89670387
Intentional dose omission	1945.94	20.91	1226	509351	16557	90101313
Arthralgia	1871.27	20.91	8993	501584	769529	89348341
Scratch	1845.75	20.91	965	509612	8901	90108969
Synovitis	1804.12	20.91	9	510568	329743	89788127
Pemphigus	1798.76	20.91	7	510570	326857	89791013
Product prescribing issue	1756.31	20.91	871	509706	7108	90110762
Cough	1736.46	20.91	5286	505291	363676	89754194
Skin irritation	1721.13	20.91	1029	509548	12574	90105296
Acute kidney injury	1684.75	20.91	23	510554	320364	89797506
Confusional state	1664.03	20.91	137	510440	386068	89731802
Hepatic enzyme increased	1656.14	20.91	93	510484	360643	89757227
Dermatitis atopic	1651.01	20.91	1232	509345	22240	90095630
Contraindicated product administered	1641.62	20.91	33	510544	320106	89797764
Hand deformity	1616.32	20.91	9	510568	296353	89821517
Glossodynia	1589.94	20.91	49	510528	321730	89796140
Vomiting	1589.82	20.91	1271	509306	787022	89330848
Injection site reaction	1587.75	20.91	2260	508317	89820	90028050
Lacrimation increased	1582.29	20.91	1273	509304	25789	90092081
Toxicity to various agents	1579.09	20.91	7	510570	287839	89830031
Death	1573.54	20.91	328	510249	456223	89661647
Systemic lupus erythematosus	1506.15	20.91	148	510429	361748	89756122
Diarrhoea	1498.22	20.91	1860	508717	937330	89180540
Nausea	1493.07	20.91	2482	508095	1107834	89010036
Anaemia	1417.71	20.91	164	510413	352638	89765232
Pericarditis	1404.74	20.91	23	510554	270128	89847742
Arthropathy	1376.84	20.91	210	510367	366032	89751838
Rash pruritic	1364.79	20.91	1982	508595	80232	90037638
Drug effect less than expected	1362.73	20.91	674	509903	5464	90112406
Eye discharge	1321.23	20.91	728	509849	7530	90110340
Nasal congestion	1311.21	20.91	1960	508617	81454	90036416
Treatment failure	1302.81	20.91	110	510467	303818	89814052
Drug interaction	1266.29	20.91	72	510505	276381	89841489
Rheumatoid arthritis	1264.57	20.91	253	510324	362361	89755509
General physical health deterioration	1256.86	20.91	239	510338	354876	89762994
Eye swelling	1229.97	20.91	1142	509435	28244	90089626
Injection site mass	1217.41	20.91	1004	509573	21086	90096784
Hypertension	1215	20.91	529	510048	457003	89660867
Neutropenia	1169.78	20.91	19	510558	224885	89892985
Hypotension	1168.61	20.91	211	510366	325186	89792684
Wound	1163.41	20.91	163	510414	302817	89815053
Drug ineffective	1148.01	20.91	12353	498224	1371945	88745925
Helicobacter infection	1129.54	20.91	32	510545	226818	89891052
Eyelids pruritus	1129.48	20.91	423	510154	1541	90116329
Eye pain	1100.92	20.91	1301	509276	42867	90075003
Extra dose administered	1089.65	20.91	665	509912	8453	90109417
Thrombocytopenia	1088.20	20.91	17	510560	208708	89909162
Impaired healing	1088.05	20.91	56	510521	234143	89883727
Product storage error	1078.10	20.91	902	509675	19339	90098531
Injection site irritation	1075.88	20.91	571	510006	5444	90112426
Lower respiratory tract infection	1043.79	20.91	102	510475	250557	89867313
Joint swelling	1025.99	20.91	801	509776	502499	89615371
Asthenia	1025.70	20.91	900	509677	532851	89585019
Type 2 diabetes mellitus	1003.36	20.91	31	510546	203213	89914657
Folliculitis	998.74	20.91	34	510543	204319	89913551
Eyelid skin dryness	981.00	20.91	283	510294	301	90117569
Psoriatic arthropathy	977.32	20.91	83	510494	228252	89889618
Intentional product use issue	953.04	20.91	70	510507	216822	89901048
Muscle injury	944.83	20.91	9	510568	176645	89941225
Oedema peripheral	928.53	20.91	166	510411	257749	89860121
Lack of injection site rotation	919.28	20.91	300	510277	631	90117239
Irritable bowel syndrome	917.10	20.91	65	510512	207383	89910487
Liver injury	910.78	20.91	9	510568	170558	89947312
Abdominal pain	904.02	20.91	556	510021	395165	89722705
Eyelid margin crusting	897.95	20.91	348	510229	1424	90116446
Abdominal discomfort	880.95	20.91	835	509742	476493	89641377
Stomatitis	867.56	20.91	237	510340	274461	89843409
Eye disorder	854.33	20.91	907	509670	26483	90091387
Erythema of eyelid	851.29	20.91	401	510176	2882	90114988
C-reactive protein increased	849.99	20.91	41	510536	181348	89936522
Injury	846.55	20.91	71	510506	197278	89920592
Swelling of eyelid	842.89	20.91	470	510107	4984	90112886
Skin discomfort	815.53	20.91	332	510245	1589	90116281
Blood cholesterol increased	814.70	20.91	105	510472	207907	89909963
Periorbital swelling	809.13	20.91	438	510139	4360	90113510
Decreased appetite	804.62	20.91	570	510007	375970	89741900
Oedema	804.34	20.91	93	510484	200202	89917668
Skin discolouration	799.52	20.91	1112	509465	43203	90074667
Completed suicide	798.05	20.91	3	510574	145055	89972815
Mobility decreased	794.23	20.91	215	510362	250519	89867351
Sleep disorder	788.51	20.91	2682	507895	195348	89922522
Ill-defined disorder	786.26	20.91	69	510508	184822	89933048
Overdose	782.18	20.91	23	510554	157686	89960184
Pain of skin	767.48	20.91	673	509904	15409	90102461
Fear of injection	755.57	20.91	515	510062	8000	90109870
Osteoarthritis	749.41	20.91	106	510471	195624	89922246
Musculoskeletal pain	744.53	20.91	58	510519	171193	89946677
Fatigue	744.23	20.91	3664	506913	1150359	88967511
Fibromyalgia	743.99	20.91	132	510445	206137	89911733
Disease progression	735.08	20.91	35	510542	156580	89961290
Stress	727.85	20.91	1492	509085	79903	90037967
Dermatitis	725.47	20.91	754	509823	21466	90096404
Injection site discomfort	716.91	20.91	436	510141	5504	90112366
Haemoglobin decreased	703.66	20.91	55	510522	161901	89955969
White blood cell count decreased	692.88	20.91	69	510508	167040	89950830
Hyponatraemia	687.10	20.91	13	510564	133525	89984345
Joint range of motion decreased	686.87	20.91	16	510561	135627	89982243
Rhinorrhoea	683.91	20.91	1527	509050	86789	90031081
C-reactive protein abnormal	669.98	20.91	9	510568	127420	89990450
Injection site warmth	659.27	20.91	642	509935	16873	90100997
Injection site dryness	655.16	20.91	217	510360	488	90117382
Musculoskeletal stiffness	654.46	20.91	433	510144	296099	89821771
Pancytopenia	653.45	20.91	4	510573	120259	89997611
Injection site vesicles	649.23	20.91	362	510215	3838	90114032
Anosmia	648.37	20.91	497	510080	9351	90108519
Hypokalaemia	643.41	20.91	21	510556	131095	89986775
Injection site discolouration	637.07	20.91	481	510096	8839	90109031
Blepharitis	618.17	20.91	344	510233	3632	90114238
Alanine aminotransferase increased	599.02	20.91	14	510563	118324	89999546
Platelet count decreased	590.85	20.91	48	510529	136921	89980949
Swollen joint count increased	584.00	20.91	8	510569	111198	90006672
Pneumonia	577.51	20.91	1765	508812	636294	89481576
Eyelid rash	576.21	20.91	174	510403	246	90117624
Malignant neoplasm progression	573.47	20.91	5	510572	106865	90011005
Fall	573.16	20.91	1157	509420	480653	89637217
Gastrointestinal disorder	570.16	20.91	372	510205	256315	89861555
Bursitis	568.28	20.91	46	510531	131608	89986262
Constipation	565.85	20.91	450	510127	279945	89837925
Injection site haemorrhage	553.77	20.91	739	509838	27579	90090291
Delirium	545.88	20.91	8	510569	104351	90013519
Hordeolum	542.83	20.91	340	510237	4538	90113332
Therapy non-responder	542.48	20.91	66	510511	136638	89981232
Prescribed overdose	531.65	20.91	3	510574	97622	90020248
Hypercholesterolaemia	530.93	20.91	7	510570	100885	90016985
Sepsis	529.68	20.91	176	510401	179638	89938232
Oropharyngeal pain	529.45	20.91	1639	508938	113548	90004322
Pyrexia	527.83	20.91	1929	508648	658556	89459314
Leukopenia	525.59	20.91	8	510569	100702	90017168
Sensitive skin	518.77	20.91	290	510287	3091	90114779
Tachycardia	518.74	20.91	125	510452	157548	89960322
Renal failure	518.02	20.91	64	510513	130943	89986927
Liver disorder	516.19	20.91	45	510532	121224	89996646
Aspartate aminotransferase increased	506.79	20.91	16	510561	102921	90014949
Intentional overdose	505.37	20.91	4	510573	93830	90024040
Wound infection	501.78	20.91	23	510554	106379	90011491
Pulmonary fibrosis	501.29	20.91	25	510552	107478	90010392
Therapeutic product effect decreased	499.34	20.91	496	510081	277075	89840795
Blood creatinine increased	498.28	20.91	16	510561	101370	90016500
Pulmonary embolism	497.97	20.91	72	510505	130748	89987122
Obesity	493.69	20.91	24	510553	105483	90012387
Swelling	489.15	20.91	1017	509560	418041	89699829
Malaise	486.30	20.91	1684	508893	584302	89533568
Adverse event	485.34	20.91	49	510528	117369	90000501
Dehydration	472.38	20.91	253	510324	194194	89923676
Pleural effusion	467.44	20.91	45	510532	111946	90005924
Cardiac arrest	466.16	20.91	32	510545	104903	90012967
Eyelid irritation	465.18	20.91	185	510392	823	90117047
Drug-induced liver injury	463.76	20.91	9	510568	90309	90027561
Muscular weakness	460.93	20.91	298	510279	206368	89911502
Sleep disorder due to general medical condition, insomnia type	460.38	20.91	84	510493	128610	89989260
Eye inflammation	460.25	20.91	370	510207	7481	90110389
Surgery	459.44	20.91	871	509706	44016	90073854
Intercepted product storage error	455.76	20.91	151	510426	340	90117530
Breast cancer stage III	452.86	20.91	4	510573	84443	90033427
Injection site exfoliation	450.05	20.91	153	510424	385	90117485
Drug abuse	446.01	20.91	3	510574	82344	90035526
Medication error	440.57	20.91	7	510570	84645	90033225
Respiratory failure	439.67	20.91	70	510507	118348	89999522
Influenza	439.39	20.91	1750	508827	137514	89980356
Eczema eyelids	434.54	20.91	135	510442	223	90117647
Weight decreased	431.58	20.91	936	509641	378974	89738896
Scab	428.52	20.91	389	510188	9332	90108538
Gastrointestinal haemorrhage	420.74	20.91	21	510556	90227	90027643
Live birth	414.01	20.91	6	510571	79101	90038769
Neurodermatitis	413.57	20.91	241	510336	2797	90115073
Peripheral venous disease	413.28	20.91	13	510564	83908	90033962
Therapeutic response unexpected	409.55	20.91	559	510018	21321	90096549
Product use issue	405.54	20.91	3212	507365	326707	89791163
Night sweats	404.56	20.91	112	510465	128654	89989216
Dyspepsia	399.66	20.91	318	510259	197842	89920028
Red blood cell sedimentation rate increased	399.00	20.91	15	510562	82580	90035290
Blood pressure increased	397.11	20.91	317	510260	196900	89920970
Grip strength decreased	394.95	20.91	34	510543	92542	90025328
Bradycardia	392.52	20.91	19	510558	83828	90034042
Septic shock	387.88	20.91	21	510556	84139	90033731
Renal impairment	387.61	20.91	64	510513	105357	90012513
Electrocardiogram QT prolonged	385.86	20.91	4	510573	72452	90045418
Liver function test increased	385.47	20.91	23	510554	84832	90033038
Acne	381.01	20.91	622	509955	27885	90089985
Deep vein thrombosis	379.25	20.91	38	510539	91582	90026288
Hand dermatitis	379.09	20.91	138	510439	454	90117416
Product quality issue	374.50	20.91	17	510560	79308	90038562
Suicide attempt	373.76	20.91	11	510566	75388	90042482
Eye infection	373.63	20.91	431	510146	13823	90104047
Epilepsy	371.26	20.91	23	510554	82183	90035687
Ocular discomfort	370.86	20.91	299	510278	6071	90111799
Hepatitis	367.50	20.91	6	510571	70733	90047137
Depressed level of consciousness	363.07	20.91	10	510567	72774	90045096
Interstitial lung disease	361.94	20.91	16	510561	76389	90041481
Seizure	359.94	20.91	206	510371	152423	89965447
Cardiac failure	355.84	20.91	89	510488	109407	90008463
Eyelid exfoliation	355.07	20.91	112	510465	200	90117670
Rectal haemorrhage	354.05	20.91	30	510547	82714	90035156
Multiple organ dysfunction syndrome	350.08	20.91	7	510570	68329	90049541
Neutrophil count decreased	348.97	20.91	12	510565	71520	90046350
Periorbital irritation	346.30	20.91	85	510492	10	90117860
Hyperkalaemia	344.05	20.91	4	510573	64960	90052910
Coma	338.26	20.91	17	510560	72615	90045255
Unintentional use for unapproved indication	335.67	20.91	109	510468	224	90117646
Gait inability	333.62	20.91	206	510371	146250	89971620
Chest pain	333.52	20.91	824	509753	318821	89799049
Urticaria	333.26	20.91	2949	507628	309785	89808085
Amnesia	330.51	20.91	100	510477	108405	90009465
Cardio-respiratory arrest	329.51	20.91	5	510572	63135	90054735
Somnolence	328.47	20.91	417	510160	208667	89909203
Lung disorder	322.21	20.91	225	510352	149658	89968212
Injection site inflammation	320.68	20.91	239	510338	4302	90113568
Drug hypersensitivity	317	20.91	1438	509139	462171	89655699
Device use issue	313.92	20.91	218	510359	3495	90114375
Sneezing	313.61	20.91	586	509991	29283	90088587
Product administered at inappropriate site	310.09	20.91	226	510351	3925	90113945
Mucosal inflammation	303.16	20.91	4	510573	57621	90060249
Cognitive disorder	302.99	20.91	23	510554	69384	90048486
Hypoglycaemia	302.51	20.91	24	510553	69824	90048046
Depression	295.84	20.91	798	509779	299803	89818067
Atrial fibrillation	290.61	20.91	198	510379	133413	89984457
Perioral dermatitis	285.10	20.91	112	510465	479	90117391
Skin disorder	284.39	20.91	635	509942	36071	90081799
Hepatic cirrhosis	281.76	20.91	19	510558	63234	90054636
Dyspnoea	281.49	20.91	6716	503861	874239	89243631
Visual impairment	281.41	20.91	1481	509096	130884	89986986
Secretion discharge	279.36	20.91	394	510183	15502	90102368
Hospitalisation	274.20	20.91	1436	509141	126664	89991206
Blood pressure systolic increased	273.81	20.91	13	510564	58332	90059538
Eye allergy	273.03	20.91	138	510439	1177	90116693
SARS-CoV-2 test positive	272.58	20.91	325	510252	10803	90107067
Suicidal ideation	271.13	20.91	45	510532	73810	90044060
Sciatica	268.86	20.91	117	510460	101265	90016605
Foot deformity	268.43	20.91	17	510560	59634	90058236
Tremor	264.75	20.91	283	510294	152890	89964980
Neuropathy peripheral	264.75	20.91	229	510348	136741	89981129
Rhabdomyolysis	263.56	20.91	5	510572	51251	90066619
Pregnancy	258.72	20.91	25	510552	62022	90055848
Wrong technique in device usage process	258.18	20.91	234	510343	5601	90112269
Liver function test abnormal	253.54	20.91	7	510570	50838	90067032
Off label use	251.26	20.91	4538	506039	1097714	89020156
Sedation	250.58	20.91	4	510573	48167	90069703
Myalgia	250.54	20.91	1768	508809	173357	89944513
Hypoxia	248.90	20.91	52	510525	72347	90045523
Encephalopathy	245.31	20.91	3	510574	46441	90071429
Hepatotoxicity	241.96	20.91	3	510574	45839	90072031
Dizziness	241.53	20.91	2140	508437	587144	89530726
Symptom recurrence	241.51	20.91	191	510386	3768	90114102
Cardiac failure congestive	240.19	20.91	128	510449	98566	90019304
Initial insomnia	238.14	20.91	278	510299	9032	90108838
Lupus vulgaris	237.60	20.91	3	510574	45056	90072814
Hypoaesthesia	235.88	20.91	940	509637	313270	89804600
Haematochezia	231.63	20.91	57	510520	70856	90047014
Underdose	229.95	20.91	20	510557	53997	90063873
Osteoporosis	229.39	20.91	129	510448	96402	90021468
Syncope	229.38	20.91	245	510332	132418	89985452
Blood bilirubin increased	228.75	20.91	3	510574	43467	90074403
Hepatic function abnormal	228.51	20.91	7	510570	46281	90071589
Lower limb fracture	227.19	20.91	97	510480	84916	90032954
Memory impairment	226.17	20.91	483	510094	196761	89921109
Ascites	226.10	20.91	10	510567	47730	90070140
Agitation	222.97	20.91	52	510525	67046	90050824
Lactic acidosis	222.33	20.91	16	510561	50447	90067423
Autoimmune disorder	219.19	20.91	79	510498	76665	90041205
Multiple sclerosis relapse	215.66	20.91	22	510555	52283	90065587
Hallucination	215.48	20.91	53	510524	65906	90051964
Gastrooesophageal reflux disease	215.31	20.91	379	510198	165958	89951912
Device expulsion	214.37	20.91	3	510574	40883	90076987
Dry mouth	213.30	20.91	448	510129	183611	89934259
Device defective	210.12	20.91	167	510410	3319	90114551
Drug reaction with eosinophilia and systemic symptoms	209.17	20.91	7	510570	42751	90075119
Blood pressure fluctuation	208.63	20.91	25	510552	52388	90065482
Eosinophil count increased	207.67	20.91	309	510268	12772	90105098
Infection	207.12	20.91	1194	509383	360900	89756970
Off label use of device	206.26	20.91	81	510496	346	90117524
Osteonecrosis of jaw	204.45	20.91	3	510574	39100	90078770
Abdominal pain upper	203.95	20.91	1072	509505	331602	89786268
Haematocrit decreased	200.66	20.91	8	510569	41824	90076046
Blood alkaline phosphatase increased	198.81	20.91	20	510557	48059	90069811
Hyperglycaemia	198.77	20.91	26	510551	50944	90066926
Plasma cell myeloma	198.62	20.91	7	510570	40821	90077049
Exostosis	198.12	20.91	31	510546	53103	90064767
Serotonin syndrome	197.70	20.91	3	510574	37884	90079986
Lupus-like syndrome	197.67	20.91	22	510555	48824	90069046
General physical condition abnormal	197.32	20.91	190	510387	4921	90112949
Lip dry	197.26	20.91	167	510410	100788	90017082
Retinitis	196.74	20.91	4	510573	38454	90079416
Balance disorder	195.38	20.91	156	510421	96924	90020946
Middle insomnia	191.50	20.91	341	510236	16410	90101460
Frequent bowel movements	191.43	20.91	43	510534	56892	90060978
Burning sensation	190.94	20.91	786	509791	62666	90055204
Chronic kidney disease	190.08	20.91	28	510549	50163	90067707
Hepatic failure	189.21	20.91	8	510569	39720	90078150
Road traffic accident	189.16	20.91	196	510381	107430	90010440
Myocardial infarction	188.50	20.91	191	510386	105781	90012089
Colitis ulcerative	188.17	20.91	53	510524	60213	90057657
Onychomadesis	187.96	20.91	20	510557	45978	90071892
Loss of consciousness	187.48	20.91	313	510264	139925	89977945
Pneumonia aspiration	186.22	20.91	11	510566	40929	90076941
Transaminases increased	185.89	20.91	5	510572	37187	90080683
Fluid retention	185.66	20.91	135	510442	87956	90029914
Hypomagnesaemia	184.93	20.91	3	510574	35585	90082285
Cholestasis	184.80	20.91	4	510573	36295	90081575
Hip arthroplasty	183.74	20.91	100	510477	76108	90041762
Upper-airway cough syndrome	183.27	20.91	316	510261	14819	90103051
Gamma-glutamyltransferase increased	182.92	20.91	7	510570	37945	90079925
Pancreatitis	182.90	20.91	82	510495	69744	90048126
Respiratory tract congestion	182.61	20.91	447	510130	26963	90090907
Nail disorder	182.48	20.91	53	510524	59014	90058856
Respiration abnormal	181.10	20.91	224	510353	7739	90110131
Anxiety	180.06	20.91	1016	509561	308756	89809114
Laboratory test abnormal	179.52	20.91	15	510562	41839	90076031
Red blood cell count decreased	177.53	20.91	25	510552	46326	90071544
Unresponsive to stimuli	177.25	20.91	9	510568	38112	90079758
Blood creatine phosphokinase increased	176.24	20.91	3	510574	34020	90083850
Foreign body sensation in eyes	175.57	20.91	147	510430	3153	90114717
Hypothyroidism	174.89	20.91	42	510535	53085	90064785
Premature delivery	174.55	20.91	11	510566	38751	90079119
Acute respiratory failure	174.51	20.91	19	510558	42899	90074971
Orthostatic hypotension	173.99	20.91	17	510560	41810	90076060
Disability	173.67	20.91	15	510562	40730	90077140
Hypercalcaemia	173.43	20.91	4	510573	34236	90083634
Foetal exposure during pregnancy	172.29	20.91	20	510557	42955	90074915
Pain	171.34	20.91	4291	506286	992050	89125820
Peripheral swelling	171.33	20.91	1495	509082	411611	89706259
Nasal obstruction	170.14	20.91	131	510446	2481	90115389
Generalised tonic-clonic seizure	169.73	20.91	6	510571	34897	90082973
Alopecia	169.15	20.91	1878	508699	493193	89624677
Productive cough	168.38	20.91	869	509708	76194	90041676
Dysarthria	168.10	20.91	49	510528	54433	90063437
Toxic epidermal necrolysis	167.95	20.91	3	510574	32525	90085345
Finger deformity	166.02	20.91	4	510573	32893	90084977
Toothache	165.98	20.91	379	510198	21851	90096019
Gait disturbance	165.49	20.91	829	509748	259667	89858203
Oesophageal food impaction	164.26	20.91	62	510515	232	90117638
Palpitations	163.31	20.91	327	510250	136401	89981469
Drug tolerance decreased	161.79	20.91	4	510573	32126	90085744
Joint dislocation	161.78	20.91	28	510549	44554	90073316
Heart rate decreased	161.67	20.91	50	510527	53455	90064415
Blood pressure decreased	161.48	20.91	112	510465	74783	90043087
Blood glucose increased	161.20	20.91	179	510398	95067	90022803
Pharyngitis streptococcal	160.83	20.91	271	510306	12471	90105399
Rosacea	160.35	20.91	181	510396	5666	90112204
Adverse drug reaction	159.22	20.91	257	510320	116444	90001426
Hepatic cytolysis	159.02	20.91	3	510574	30913	90086957
Altered state of consciousness	158.50	20.91	4	510573	31528	90086342
Full blood count abnormal	157.29	20.91	13	510564	36584	90081286
Nasal polyps	157.18	20.91	246	510331	10634	90107236
Acute myocardial infarction	156.81	20.91	10	510567	34880	90082990
Jaundice	156.71	20.91	6	510571	32511	90085359
Femur fracture	156.55	20.91	34	510543	46048	90071822
Coeliac disease	155.49	20.91	31	510546	44579	90073291
Injection site eczema	155.30	20.91	46	510531	58	90117812
Pharyngeal swelling	155.15	20.91	233	510344	9711	90108159
Lymphocyte count decreased	154.73	20.91	11	510566	35039	90082831
Sinus operation	154.52	20.91	131	510446	2860	90115010
Respiratory arrest	154.46	20.91	8	510569	33303	90084567
Contusion	153.62	20.91	810	509767	250406	89867464
Injection site nodule	153.61	20.91	156	510421	4317	90113553
Skin mass	153.13	20.91	199	510378	7231	90110639
Colitis	152.92	20.91	103	510474	69839	90048031
Periorbital inflammation	151.97	20.91	53	510524	148	90117722
Eosinophilic oesophagitis	151.90	20.91	81	510496	780	90117090
Cholelithiasis	151.73	20.91	53	510524	52453	90065417
Pulmonary hypertension	151.50	20.91	28	510549	42495	90075375
Hypophagia	151.09	20.91	14	510563	35923	90081947
Device dislocation	151.07	20.91	6	510571	31476	90086394
Coronary artery disease	150.04	20.91	10	510567	33613	90084257
Disorientation	148.94	20.91	33	510544	44081	90073789
Haematuria	148.53	20.91	13	510564	34924	90082946
Drug effective for unapproved indication	147.72	20.91	202	510375	7716	90110154
Haematemesis	147.69	20.91	11	510566	33715	90084155
Skin erosion	146.45	20.91	134	510443	3248	90114622
Intentional self-injury	146.40	20.91	4	510573	29330	90088540
Sinus tachycardia	145.72	20.91	3	510574	28510	90089360
Urinary tract infection	144.66	20.91	1067	509510	304565	89813305
Acute respiratory distress syndrome	142.84	20.91	4	510573	28682	90089188
Eosinophilic granulomatosis with polyangiitis	141.47	20.91	116	510461	2414	90115456
Mood disorder due to a general medical condition	141.39	20.91	45	510532	84	90117786
Asthenopia	141.14	20.91	123	510454	2791	90115079
Skin texture abnormal	139.60	20.91	68	510509	531	90117339
Rash maculo-papular	139.46	20.91	30	510547	40903	90076967
Drug withdrawal syndrome	139.46	20.91	5	510572	28718	90089152
Walking aid user	138.72	20.91	18	510559	35488	90082382
Food allergy	138.46	20.91	385	510192	25093	90092777
Facial discomfort	138.32	20.91	57	510520	283	90117587
Pulmonary oedema	137.64	20.91	90	510487	61990	90055880
Hypervolaemia	137.09	20.91	13	510564	32744	90085126
Urinary retention	136.32	20.91	24	510553	37720	90080150
Blood urea increased	135.85	20.91	9	510568	30404	90087466
Aphasia	134.87	20.91	37	510540	42775	90075095
White blood cell count increased	134.11	20.91	109	510468	67132	90050738
Miliaria	132.79	20.91	90	510487	1384	90116486
Injection site induration	132.61	20.91	223	510354	10245	90107625
Arrhythmia	132.58	20.91	37	510540	42295	90075575
Palmar-plantar erythrodysaesthesia syndrome	132.28	20.91	6	510571	28017	90089853
Hyposmia	132.25	20.91	77	510500	892	90116978
Drainage	131.70	20.91	52	510525	226	90117644
Blood lactate dehydrogenase increased	131.46	20.91	3	510574	25929	90091941
Cytomegalovirus infection	131.40	20.91	4	510573	26598	90091272
Metastases to liver	130.24	20.91	8	510569	28799	90089071
Shock	130.08	20.91	8	510569	28770	90089100
Drug dependence	130.05	20.91	9	510568	29318	90088552
Inflammation	129.69	20.91	541	510036	178051	89939819
Psychotic disorder	129.10	20.91	13	510564	31217	90086653
Angina pectoris	128.82	20.91	31	510546	39129	90078741
Skin warm	128.41	20.91	186	510391	7501	90110369
Rash papular	128.28	20.91	325	510252	20030	90097840
Dyskinesia	128.15	20.91	25	510552	36509	90081361
Body temperature increased	127.71	20.91	46	510531	44664	90073206
Oxygen saturation decreased	127.54	20.91	258	510319	107225	90010645
Paranasal sinus discomfort	127.47	20.91	166	510411	6044	90111826
Dandruff	127.47	20.91	54	510523	291	90117579
Angioedema	127.12	20.91	107	510470	64769	90053101
Injection site discharge	126.93	20.91	87	510490	1364	90116506
Pancreatitis acute	126.15	20.91	16	510561	32099	90085771
Ejection fraction decreased	125.99	20.91	5	510572	26248	90091622
Metastases to bone	125.38	20.91	4	510573	25501	90092369
Eyelid pain	125.16	20.91	69	510508	714	90117156
Drug resistance	125.03	20.91	13	510564	30436	90087434
Ventricular tachycardia	124.71	20.91	3	510574	24705	90093165
Full blood count decreased	123.67	20.91	12	510565	29677	90088193
Muscle spasms	122.72	20.91	872	509705	251011	89866859
Stevens-Johnson syndrome	122.03	20.91	12	510565	29364	90088506
Abdominal distension	121.46	20.91	356	510221	130245	89987625
Exposure during pregnancy	121.26	20.91	815	509762	237595	89880275
Basal cell carcinoma	121.09	20.91	21	510556	33368	90084502
Respiratory distress	120.20	20.91	35	510542	38911	90078959
Blood pressure diastolic decreased	119.64	20.91	8	510569	26818	90091052
Clostridium difficile colitis	119.00	20.91	8	510569	26698	90091172
Pneumonitis	118.64	20.91	50	510527	44120	90073750
Red blood cell sedimentation rate abnormal	118.26	20.91	4	510573	24200	90093670
Nasopharyngitis	117.25	20.91	3063	507514	404041	89713829
Needle issue	116.96	20.91	249	510328	13685	90104185
Cardiogenic shock	116.28	20.91	5	510572	24463	90093407
Hepatic steatosis	116.25	20.91	32	510545	36913	90080957
Blood calcium decreased	116.25	20.91	16	510561	30166	90087704
Oropharyngeal discomfort	116.09	20.91	178	510399	7557	90110313
Sunburn	115.96	20.91	116	510461	3151	90114719
Atelectasis	115.96	20.91	5	510572	24404	90093466
Hallucination, visual	115.80	20.91	3	510574	23089	90094781
Cystitis	115.54	20.91	123	510454	66595	90051275
Myositis	114.43	20.91	5	510572	24123	90093747
Cerebral haemorrhage	114.20	20.91	27	510550	34495	90083375
Dysgeusia	114.10	20.91	78	510499	52482	90065388
Pulmonary arterial hypertension	113.38	20.91	9	510568	26178	90091692
Sensitivity to weather change	113.06	20.91	190	510387	8724	90109146
Onychomycosis	112.79	20.91	35	510542	37341	90080529
Diabetic ketoacidosis	112.73	20.91	6	510571	24401	90093469
Adrenal insufficiency	112.59	20.91	17	510560	29904	90087966
Discomfort	112.32	20.91	2170	508407	272165	89845705
Disease recurrence	112.31	20.91	36	510541	37617	90080253
Upper gastrointestinal haemorrhage	111.55	20.91	4	510573	22972	90094898
Device related infection	111.26	20.91	9	510568	25777	90092093
Cerebral infarction	110.13	20.91	11	510566	26585	90091285
Proteinuria	109.89	20.91	5	510572	23286	90094584
Back injury	109.75	20.91	63	510514	46559	90071311
Hyperlipidaemia	107.86	20.91	5	510572	22911	90094959
Pustule	107.22	20.91	105	510472	2778	90115092
Injury associated with device	107.07	20.91	129	510448	4335	90113535
Accidental overdose	106.53	20.91	16	510561	28257	90089613
Taste disorder	105.98	20.91	114	510463	61432	90056438
Conjunctivitis allergic	105.16	20.91	75	510502	1257	90116613
Neck pain	104.27	20.91	313	510264	113650	90004220
Circulatory collapse	103.91	20.91	10	510567	24894	90092976
Ulcer haemorrhage	103.66	20.91	13	510564	26308	90091562
Haematoma	103.61	20.91	45	510532	39003	90078867
Cellulitis	102.70	20.91	226	510351	91111	90026759
Immunodeficiency	102.38	20.91	58	510519	43176	90074694
Premature baby	102.21	20.91	11	510566	25066	90092804
Skin depigmentation	101.82	20.91	70	510507	1103	90116767
Cerebrovascular accident	101.42	20.91	356	510221	123177	89994693
Hemiparesis	101.17	20.91	27	510550	31792	90086078
Osteonecrosis	100.85	20.91	14	510563	26227	90091643
Electrolyte imbalance	100.50	20.91	9	510568	23736	90094134
Lip erythema	99.61	20.91	48	510529	365	90117505
Pallor	99.56	20.91	34	510543	34131	90083739
Gastric disorder	99.43	20.91	32	510545	33352	90084518
Tachypnoea	99.17	20.91	5	510572	21304	90096566
Abdominal pain lower	99.04	20.91	24	510553	30153	90087717
Therapeutic product effect incomplete	98.99	20.91	662	509915	193234	89924636
Chapped lips	98.30	20.91	100	510477	2773	90115097
Infection parasitic	98.11	20.91	52	510525	494	90117376
Foetal death	96.01	20.91	5	510572	20718	90097152
Lymphopenia	95.96	20.91	9	510568	22872	90094998
Injection site scar	95.17	20.91	69	510508	1188	90116682
Intentional product misuse	94.72	20.91	844	509733	88760	90029110
Respiratory syncytial virus infection	94.66	20.91	193	510384	10287	90107583
Right ventricular failure	94.45	20.91	3	510574	19202	90098668
Aggression	94.06	20.91	18	510559	26650	90091220
Eosinophilic pneumonia	93.93	20.91	96	510481	2677	90115193
Heart rate increased	92.93	20.91	325	510252	112577	90005293
Bacteraemia	92.92	20.91	9	510568	22291	90095579
Urosepsis	92.76	20.91	7	510570	21225	90096645
Intestinal obstruction	92.04	20.91	47	510530	37084	90080786
Adverse reaction	91.15	20.91	27	510550	29685	90088185
Dermatitis contact	90.86	20.91	222	510355	13373	90104497
Body temperature decreased	90.84	20.91	13	510564	23803	90094067
Myoclonus	90.82	20.91	4	510573	19164	90098706
Pericardial effusion	90.74	20.91	47	510530	36786	90081084
Coagulopathy	90.52	20.91	12	510565	23277	90094593
Treatment noncompliance	89.97	20.91	95	510482	51632	90066238
Pneumocystis jirovecii pneumonia	89.35	20.91	9	510568	21607	90096263
Therapy partial responder	89.01	20.91	10	510567	22033	90095837
Clostridium difficile infection	88.18	20.91	47	510530	36198	90081672
Coordination abnormal	87.99	20.91	9	510568	21347	90096523
Iron deficiency anaemia	87.77	20.91	14	510563	23648	90094222
Peritonitis	87.52	20.91	6	510571	19699	90098171
Radiculopathy	87.22	20.91	4	510573	18501	90099369
Urinary incontinence	86.67	20.91	52	510525	37514	90080356
Vaginal haemorrhage	86.26	20.91	34	510543	31237	90086633
Drug eruption	86.01	20.91	46	510531	35361	90082509
Scar	85.99	20.91	235	510342	15160	90102710
Spinal operation	85.35	20.91	182	510395	10014	90107856
Cardiomyopathy	84.60	20.91	8	510569	20198	90097672
Poor venous access	83.74	20.91	7	510570	19520	90098350
Menstruation delayed	83.30	20.91	80	510497	2065	90115805
Maternal exposure during pregnancy	82.85	20.91	1478	509099	358585	89759285
Pyelonephritis	82.81	20.91	11	510566	21305	90096565
Exfoliative rash	82.78	20.91	96	510481	3096	90114774
Ischaemic stroke	82.48	20.91	13	510564	22153	90095717
Haemorrhoids	82.40	20.91	24	510553	26678	90091192
Osteomyelitis	82.38	20.91	27	510550	27819	90090051
Device operational issue	82.35	20.91	58	510519	952	90116918
Lack of administration site rotation	81.72	20.91	25	510552	38	90117832
Affect lability	81.71	20.91	5	510572	18058	90099812
Viral infection	81.59	20.91	454	510123	40960	90076910
Platelet count increased	80.47	20.91	11	510566	20848	90097022
Vitreous floaters	80.35	20.91	149	510428	7400	90110470
Gastroenteritis	80.26	20.91	32	510545	29197	90088673
Drug ineffective for unapproved indication	80.09	20.91	646	509931	65998	90051872
Polyneuropathy	80.08	20.91	8	510569	19333	90098537
Ileus	79.92	20.91	3	510574	16543	90101327
Joint effusion	79.44	20.91	9	510568	19701	90098169
Aphonia	78.99	20.91	198	510379	12121	90105749
Transient ischaemic attack	78.86	20.91	76	510501	43100	90074770
Ataxia	78.68	20.91	6	510571	18036	90099834
Leukocytosis	78.66	20.91	38	510539	30952	90086918
Cytopenia	78.42	20.91	5	510572	17444	90100426
Swelling face	78.28	20.91	751	509826	80601	90037269
Drug tolerance	78.01	20.91	6	510571	17910	90099960
Seronegative arthritis	76.93	20.91	7	510570	18227	90099643
Skin hypertrophy	76.45	20.91	98	510479	3512	90114358
Blood potassium decreased	76.12	20.91	94	510483	47633	90070237
Pigmentation disorder	75.71	20.91	127	510450	5822	90112048
Skin necrosis	75.70	20.91	5	510572	16936	90100934
Small intestinal obstruction	75.60	20.91	14	510563	21220	90096650
Dyshidrotic eczema	74.66	20.91	49	510528	712	90117158
Abnormal behaviour	74.26	20.91	18	510559	22610	90095260
Diabetes mellitus inadequate control	74.14	20.91	9	510568	18675	90099195
Vaginal discharge	73.37	20.91	11	510566	19453	90098417
Obstructive airways disorder	73.23	20.91	27	510550	25842	90092028
Hypoalbuminaemia	73.13	20.91	4	510573	15893	90101977
Exposure via eye contact	72.88	20.91	19	510558	8	90117862
Spinal compression fracture	72.47	20.91	3	510574	15175	90102695
Visual acuity reduced	72.31	20.91	21	510556	23389	90094481
Bone disorder	70.94	20.91	21	510556	23099	90094771
Transfusion	70.44	20.91	8	510569	17480	90100390
Keratitis	69.95	20.91	99	510478	3907	90113963
Motor dysfunction	69.94	20.91	12	510565	19218	90098652
Bone density decreased	69.70	20.91	8	510569	17337	90100533
Temperature regulation disorder	69.21	20.91	3	510574	14576	90103294
Breast cancer metastatic	69.02	20.91	4	510573	15128	90102742
Haemoptysis	68.98	20.91	52	510525	33268	90084602
Complication associated with device	68.87	20.91	13	510564	19436	90098434
Oral candidiasis	68.81	20.91	59	510518	35396	90082474
Knee arthroplasty	68.75	20.91	239	510338	82943	90034927
Lethargy	68.72	20.91	159	510418	62980	90054890
Sensory loss	68.63	20.91	10	510567	18065	90099805
Superficial injury of eye	68.28	20.91	37	510540	369	90117501
Increased viscosity of upper respiratory secretion	68.27	20.91	32	510545	227	90117643
Musculoskeletal disorder	68.22	20.91	19	510558	21750	90096120
Schizophrenia	67.85	20.91	4	510573	14910	90102960
Chest discomfort	67.73	20.91	1126	509451	137239	89980631
Gastric ulcer	67.65	20.91	35	510542	27413	90090457
Glomerular filtration rate decreased	67.57	20.91	8	510569	16924	90100946
Brain oedema	67.47	20.91	9	510568	17376	90100494
Dystonia	66.99	20.91	8	510569	16811	90101059
Diabetes mellitus	66.95	20.91	168	510409	64707	90053163
Osteopenia	66.84	20.91	23	510554	22979	90094891
Skin wound	66.71	20.91	68	510509	1890	90115980
Malnutrition	66.58	20.91	12	510565	18546	90099324
Neutrophil count increased	66.48	20.91	14	510563	19376	90098494
Skin atrophy	66.36	20.91	115	510462	5414	90112456
Hyperhidrosis	66.28	20.91	472	510105	135833	89982037
Cardiomegaly	66.27	20.91	13	510564	18912	90098958
Nasal polypectomy	66.05	20.91	21	510556	39	90117831
Injection site hypoaesthesia	65.69	20.91	43	510534	622	90117248
Emotional distress	65.27	20.91	66	510511	36596	90081274
Myocardial ischaemia	65.06	20.91	3	510574	13811	90104059
Pharyngeal oedema	64.83	20.91	3	510574	13768	90104102
Cardiac murmur	64.77	20.91	12	510565	18182	90099688
Back pain	64.64	20.91	1329	509248	315846	89802024
Muscle rigidity	64.61	20.91	4	510573	14305	90103565
Device dispensing error	64.33	20.91	28	510549	163	90117707
Knee operation	64.15	20.91	129	510448	6807	90111063
Product complaint	63.36	20.91	3	510574	13497	90104373
Spinal osteoarthritis	63.29	20.91	15	510562	19133	90098737
Face oedema	63.26	20.91	26	510551	23292	90094578
Allergy to animal	62.93	20.91	61	510516	1593	90116277
Mydriasis	62.71	20.91	6	510571	15006	90102864
Blood test abnormal	62.54	20.91	20	510557	20932	90096938
Anaphylactic shock	62.11	20.91	52	510525	31565	90086305
Aplastic anaemia	62.11	20.91	3	510574	13266	90104604
Keratoconus	61.99	20.91	18	510559	20	90117850
Laryngitis	61.77	20.91	120	510457	50633	90067237
Blepharospasm	61.66	20.91	138	510439	55307	90062563
Injection site indentation	61.57	20.91	32	510545	291	90117579
Fear	61.28	20.91	10	510567	16612	90101258
Breast cancer	61.28	20.91	132	510445	53629	90064241
Hypertensive crisis	60.65	20.91	13	510564	17771	90100099
Periorbital pain	59.17	20.91	31	510546	287	90117583
Escherichia urinary tract infection	59.11	20.91	5	510572	13810	90104060
Hemiplegia	58.96	20.91	10	510567	16150	90101720
Poisoning	58.76	20.91	8	510569	15209	90102661
Thrombosis	58.18	20.91	214	510363	73037	90044833
Blood potassium increased	58.16	20.91	22	510555	20727	90097143
Flank pain	58.00	20.91	18	510559	19204	90098666
Foreign body in eye	57.75	20.91	26	510551	166	90117704
Lip exfoliation	57.69	20.91	42	510535	728	90117142
Supraventricular tachycardia	57.67	20.91	11	510566	16325	90101545
Hydronephrosis	57.43	20.91	3	510574	12399	90105471
Panniculitis	57.28	20.91	7	510570	14451	90103419
Blood pressure diastolic increased	57.11	20.91	4	510573	12902	90104968
Cholecystitis	57.01	20.91	13	510564	17027	90100843
Gangrene	56.95	20.91	4	510573	12872	90104998
Intestinal perforation	56.80	20.91	6	510571	13875	90103995
Ocular surface disease	56.80	20.91	20	510557	58	90117812
Eczema asteatotic	56.46	20.91	31	510546	318	90117552
Respiratory disorder	56.46	20.91	182	510395	64634	90053236
Nephropathy toxic	55.95	20.91	4	510573	12684	90105186
Dysuria	55.40	20.91	85	510492	39316	90078554
Withdrawal syndrome	55.10	20.91	29	510548	22495	90095375
Anal incontinence	55.07	20.91	12	510565	16218	90101652
Myopathy	54.92	20.91	6	510571	13512	90104358
Cutaneous T-cell lymphoma	54.72	20.91	56	510521	1564	90116306
Abortion induced	54.66	20.91	3	510574	11885	90105985
Menstruation irregular	54.27	20.91	132	510445	7928	90109942
Colitis ischaemic	54.14	20.91	4	510573	12342	90105528
Cyanosis	53.91	20.91	21	510556	19434	90098436
Cheilitis	53.51	20.91	99	510478	4908	90112962
Chronic sinusitis	53.45	20.91	34	510543	23768	90094102
Central nervous system lesion	53.36	20.91	3	510574	11643	90106227
Rales	53.10	20.91	12	510565	15815	90102055
Nasal dryness	53.03	20.91	105	510472	5478	90112392
Renal disorder	52.92	20.91	82	510495	37777	90080093
Idiopathic urticaria	52.47	20.91	30	510547	335	90117535
Injection site hypersensitivity	52.33	20.91	70	510507	2617	90115253
Hypotonia	52.18	20.91	3	510574	11423	90106447
Skin tightness	52.12	20.91	92	510485	4396	90113474
Vascular device infection	52.05	20.91	4	510573	11948	90105922
Eczema weeping	52.04	20.91	16	510561	25	90117845
Injection site paraesthesia	52.03	20.91	38	510539	662	90117208
Cardiac failure acute	51.92	20.91	4	510573	11925	90105945
General symptom	51.52	20.91	10	510567	14658	90103212
Migraine	51.21	20.91	759	509818	189633	89928237
Arthropod bite	51.15	20.91	136	510441	8631	90109239
Product used for unknown indication	51.12	20.91	39	510538	728	90117142
Chills	50.95	20.91	486	510091	131495	89986375
Tooth disorder	50.89	20.91	60	510517	31030	90086840
Toxic skin eruption	50.88	20.91	13	510564	15761	90102109
Polyarthritis	50.53	20.91	20	510557	18330	90099540
Alcohol intolerance	50.52	20.91	21	510556	107	90117763
Hand-foot-and-mouth disease	50.49	20.91	33	510544	476	90117394
Deformity	50.48	20.91	5	510572	12165	90105705
Infusion site pain	50.41	20.91	24	510553	19714	90098156
Restlessness	50.28	20.91	77	510500	35643	90082227
Anaphylactic reaction	50.26	20.91	288	510289	87236	90030634
Skin hyperpigmentation	50.25	20.91	116	510461	6735	90111135
Diverticulum	50.18	20.91	5	510572	12108	90105762
Respiratory rate increased	50.08	20.91	14	510563	15987	90101883
Fistula	50.05	20.91	5	510572	12084	90105786
Skin wrinkling	49.57	20.91	50	510527	1372	90116498
Macular degeneration	49.56	20.91	86	510491	37884	90079986
Splenomegaly	49.42	20.91	7	510570	12917	90104953
Body height decreased	49.32	20.91	5	510572	11944	90105926
Ear discomfort	48.55	20.91	147	510430	10053	90107817
Quality of life decreased	48.07	20.91	162	510415	11727	90106143
Spinal stenosis	47.97	20.91	19	510558	17405	90100465
Metastases to lymph nodes	47.97	20.91	5	510572	11684	90106186
Dysphagia	47.90	20.91	894	509683	111384	90006486
Parosmia	47.85	20.91	116	510461	6953	90110917
Urine output decreased	47.79	20.91	7	510570	12596	90105274
Incorrect dose administered by device	47.55	20.91	102	510475	5635	90112235
Blister	47.44	20.91	1084	509493	253914	89863956
Renal cyst	47.28	20.91	8	510569	12942	90104928
Speech disorder	47.07	20.91	118	510459	45467	90072403
Mania	46.81	20.91	11	510566	14113	90103757
Seborrhoeic dermatitis	46.75	20.91	53	510524	1667	90116203
Pain in jaw	46.66	20.91	128	510449	47857	90070013
Tardive dyskinesia	46.64	20.91	4	510573	10926	90106944
Sudden death	46.53	20.91	4	510573	10905	90106965
Hepatitis acute	46.42	20.91	4	510573	10883	90106987
Ecchymosis	46.37	20.91	7	510570	12316	90105554
Dermatitis bullous	46.23	20.91	3	510574	10313	90107557
Menstrual disorder	46.21	20.91	105	510472	6033	90111837
Aspergillus infection	46.08	20.91	4	510573	10819	90107051
Paraesthesia	46.05	20.91	1066	509511	249260	89868610
Injection site injury	46.05	20.91	41	510536	958	90116912
Molluscum contagiosum	45.92	20.91	27	510550	319	90117551
Renal injury	45.84	20.91	3	510574	10240	90107630
Product administration error	45.42	20.91	49	510528	26374	90091496
Ocular rosacea	45.38	20.91	12	510565	6	90117864
Arthritis	45.34	20.91	666	509911	166649	89951221
Skin lesion	45.32	20.91	363	510214	37002	90080868
Hypogammaglobulinaemia	45.30	20.91	4	510573	10670	90107200
Photophobia	45.16	20.91	238	510339	21031	90096839
Encephalitis	45.08	20.91	5	510572	11129	90106741
Aspiration	45.07	20.91	16	510561	15677	90102193
Fungal skin infection	44.80	20.91	95	510482	5206	90112664
Skin discharge	44.75	20.91	18	510559	83	90117787
Photosensitivity reaction	44.73	20.91	209	510368	17598	90100272
Pre-eclampsia	44.64	20.91	5	510572	11043	90106827
Enterococcal infection	44.49	20.91	3	510574	9988	90107882
Multiple sclerosis	44.22	20.91	55	510522	27785	90090085
Pleuritic pain	44.18	20.91	4	510573	10457	90107413
Bronchopulmonary aspergillosis	43.99	20.91	6	510571	11392	90106478
Cushingoid	43.83	20.91	4	510573	10391	90107479
Decreased activity	43.73	20.91	123	510454	8069	90109801
Therapeutic response delayed	43.44	20.91	37	510540	813	90117057
Acute coronary syndrome	43.42	20.91	5	510572	10808	90107062
Blood sodium decreased	43.39	20.91	55	510522	27558	90090312
Nasal pruritus	43.23	20.91	35	510542	715	90117155
Lung infiltration	43.17	20.91	16	510561	15266	90102604
Blood triglycerides increased	43.14	20.91	12	510565	13749	90104121
Large intestine perforation	43.01	20.91	3	510574	9709	90108161
Product administration interrupted	42.87	20.91	9	510568	12483	90105387
Troponin increased	42.74	20.91	11	510566	13270	90104600
Escherichia infection	42.67	20.91	18	510559	15877	90101993
Blood loss anaemia	42.49	20.91	4	510573	10136	90107734
Gestational diabetes	42.23	20.91	5	510572	10577	90107293
Skin hypopigmentation	42.10	20.91	42	510535	1137	90116733
Sinus disorder	41.97	20.91	335	510242	34112	90083758
Anhedonia	41.87	20.91	7	510570	11424	90106446
Faecaloma	41.45	20.91	5	510572	10426	90107444
Hyperthyroidism	41.33	20.91	26	510551	18284	90099586
Hyperthermia	40.95	20.91	5	510572	10330	90107540
Vitamin D deficiency	40.93	20.91	24	510553	17532	90100338
Nephropathy	40.47	20.91	3	510574	9232	90108638
Fracture	40.15	20.91	39	510538	22037	90095833
Skin ulcer	39.96	20.91	445	510132	49630	90068240
Intervertebral disc degeneration	39.72	20.91	24	510553	17250	90100620
Oligomenorrhoea	39.69	20.91	39	510538	1036	90116834
Arteriosclerosis coronary artery	39.69	20.91	4	510573	9599	90108271
Eyelid thickening	39.40	20.91	16	510561	76	90117794
Vasculitis	39.10	20.91	42	510535	22651	90095219
Eye operation	38.78	20.91	61	510516	2648	90115222
Blood calcium increased	38.78	20.91	10	510567	12048	90105822
Arterial occlusive disease	38.75	20.91	11	510566	12435	90105435
Eczema nummular	38.74	20.91	23	510554	277	90117593
Pelvic pain	38.72	20.91	19	510558	15338	90102532
Lower gastrointestinal haemorrhage	38.65	20.91	3	510574	8889	90108981
Epstein-Barr virus infection	38.64	20.91	6	510571	10338	90107532
Infusion site extravasation	38.56	20.91	6	510571	10322	90107548
Atrial flutter	38.50	20.91	7	510570	10751	90107119
Spondylitis	38.15	20.91	16	510561	14162	90103708
Choking	37.73	20.91	151	510426	11882	90105988
Pulmonary mass	37.71	20.91	65	510512	28707	90089163
Enterobiasis	37.70	20.91	17	510560	109	90117761
Nightmare	37.67	20.91	40	510537	21685	90096185
Spinal fracture	37.65	20.91	41	510536	21975	90095895
Tinnitus	37.56	20.91	121	510456	42981	90074889
Infusion site erythema	37.48	20.91	15	510562	13655	90104215
Pre-existing condition improved	37.43	20.91	4	510573	9165	90108705
Breath sounds abnormal	37.36	20.91	20	510557	15366	90102504
Faeces discoloured	37.25	20.91	39	510538	21281	90096589
Presyncope	37.16	20.91	77	510500	31728	90086142
Mouth ulceration	37.12	20.91	109	510468	39865	90078005
Monocyte count increased	37.05	20.91	4	510573	9093	90108777
Breast cancer female	36.87	20.91	174	510403	14712	90103158
Eye symptom	36.69	20.91	18	510559	143	90117727
Hiatus hernia	36.34	20.91	54	510523	25307	90092563
Sinus headache	36.31	20.91	99	510478	6377	90111493
Therapy interrupted	36.21	20.91	152	510425	49956	90067914
Large intestine polyp	36.09	20.91	5	510572	9381	90108489
Staphylococcal sepsis	36.07	20.91	5	510572	9378	90108492
Nervous system disorder	36.07	20.91	41	510536	21552	90096318
Device breakage	35.98	20.91	17	510560	14027	90103843
Hepatomegaly	35.92	20.91	15	510562	13311	90104559
Dark circles under eyes	35.71	20.91	29	510548	595	90117275
Ventricular extrasystoles	35.58	20.91	15	510562	13235	90104635
SARS-CoV-1 test positive	35.48	20.91	10	510567	9	90117861
Disturbance in attention	35.24	20.91	141	510436	46968	90070902
Genital haemorrhage	35.00	20.91	4	510573	8698	90109172
Myocarditis	34.93	20.91	17	510560	13789	90104081
Abnormal sensation in eye	34.85	20.91	49	510528	1922	90115948
Ulcer	34.83	20.91	84	510493	32798	90085072
Chromaturia	34.77	20.91	34	510543	19153	90098717
Mental impairment	34.73	20.91	26	510551	16694	90101176
Procedural pain	34.72	20.91	86	510491	33274	90084596
Pathogen resistance	34.55	20.91	3	510574	8112	90109758
Tinea infection	34.35	20.91	40	510537	1296	90116574
End stage renal disease	34.33	20.91	4	510573	8567	90109303
Enteritis	34.28	20.91	8	510569	10313	90107557
Polymenorrhoea	34.07	20.91	41	510536	1376	90116494
Affective disorder	34.03	20.91	109	510468	7684	90110186
Decubitus ulcer	34.00	20.91	12	510565	11801	90106069
Fungal infection	33.99	20.91	379	510198	42282	90075588
Apathy	33.92	20.91	10	510567	11030	90106840
Lip pruritus	33.77	20.91	40	510537	1320	90116550
Eczema herpeticum	33.71	20.91	19	510558	206	90117664
Cardiovascular disorder	33.55	20.91	17	510560	13475	90104395
Periorbital disorder	33.54	20.91	12	510565	37	90117833
Bronchiectasis	33.53	20.91	46	510531	22284	90095586
Blood magnesium decreased	33.12	20.91	24	510553	15669	90102201
Nasal operation	33.04	20.91	21	510556	288	90117582
Breast cancer stage I	32.89	20.91	7	510570	9617	90108253
Colitis microscopic	32.70	20.91	11	510566	11148	90106722
Eye ulcer	32.58	20.91	24	510553	424	90117446
Swollen tear duct	32.55	20.91	11	510566	27	90117843
Facial paralysis	32.47	20.91	24	510553	15510	90102360
Weight fluctuation	32.44	20.91	38	510539	19711	90098159
Deafness	32.20	20.91	48	510529	22466	90095404
Synovial cyst	32.05	20.91	13	510564	11739	90106131
Product dispensing issue	31.55	20.91	24	510553	446	90117424
Mood altered	31.18	20.91	184	510393	16960	90100910
Staphylococcal bacteraemia	31.16	20.91	3	510574	7466	90110404
Gluten sensitivity	31.12	20.91	30	510547	778	90117092
Arthritis bacterial	31.03	20.91	3	510574	7442	90110428
Major depression	31.00	20.91	9	510568	10026	90107844
Drug dose omission by device	30.97	20.91	127	510450	10104	90107766
Product availability issue	30.82	20.91	3	510574	7401	90110469
Blood lactic acid increased	30.80	20.91	6	510571	8772	90109098
Bundle branch block left	30.79	20.91	4	510573	7881	90109989
Serum ferritin increased	30.70	20.91	3	510574	7378	90110492
Psychomotor hyperactivity	30.61	20.91	17	510560	12796	90105074
Incorrect dose administered by product	30.56	20.91	19	510558	250	90117620
Congestive cardiomyopathy	30.56	20.91	3	510574	7351	90110519
Ankylosing spondylitis	30.55	20.91	18	510559	13115	90104755
Diverticulum intestinal	30.54	20.91	7	510570	9135	90108735
Abortion spontaneous	30.43	20.91	179	510398	53877	90063993
Exposure to extreme temperature	30.26	20.91	8	510569	4	90117866
Atrial septal defect	30.25	20.91	5	510572	8229	90109641
Embolism	30.23	20.91	8	510569	9473	90108397
Dry throat	30.03	20.91	106	510471	7854	90110016
Enthesopathy	29.86	20.91	8	510569	9396	90108474
Aortic arteriosclerosis	29.77	20.91	4	510573	7680	90110190
Renal function test abnormal	29.71	20.91	3	510574	7188	90110682
Seborrhoea	29.63	20.91	25	510552	542	90117328
Decreased interest	29.49	20.91	72	510505	4335	90113535
Tuberculosis	29.47	20.91	17	510560	12532	90105338
Sticky skin	29.46	20.91	10	510567	25	90117845
Swollen tongue	29.28	20.91	146	510431	45810	90072060
Paralysis	29.24	20.91	14	510563	11464	90106406
Lymphadenopathy	29.22	20.91	390	510187	45385	90072485
Protein total decreased	29.17	20.91	3	510574	7086	90110784
Pulmonary haemorrhage	29.14	20.91	5	510572	8008	90109862
Shoulder operation	28.97	20.91	56	510521	2870	90115000
Autoimmune hepatitis	28.97	20.91	11	510566	10340	90107530
Infusion site swelling	28.80	20.91	15	510562	11705	90106165
Metabolic disorder	28.67	20.91	4	510573	7466	90110404
Intercepted product dispensing error	28.17	20.91	15	510562	144	90117726
Pain in extremity	28.07	20.91	2171	508406	448358	89669512
Oesophageal candidiasis	27.82	20.91	3	510574	6826	90111044
Mass	27.77	20.91	28	510549	15549	90102321
Postoperative wound infection	27.73	20.91	21	510556	13405	90104465
Eyelid infection	27.70	20.91	20	510557	342	90117528
Eczema infected	27.65	20.91	15	510562	150	90117720
Partial seizures	27.60	20.91	4	510573	7256	90110614
Injection site dermatitis	27.50	20.91	8	510569	9	90117861
Nystagmus	27.44	20.91	4	510573	7223	90110647
Product prescribing error	27.38	20.91	275	510302	29870	90088000
Candida infection	27.37	20.91	99	510478	33958	90083912
Inappropriate schedule of product discontinuation	27.30	20.91	11	510566	51	90117819
Iron deficiency	27.26	20.91	10	510567	9602	90108268
Eye injury	27.23	20.91	14	510563	11006	90106864
Lip blister	27.18	20.91	54	510523	2824	90115046
Left ventricular failure	27.15	20.91	3	510574	6697	90111173
Haemoglobin abnormal	26.79	20.91	4	510573	7096	90110774
Allergy to plants	26.51	20.91	28	510549	812	90117058
Incontinence	26.51	20.91	22	510555	13413	90104457
Haemoglobin increased	26.49	20.91	5	510572	7476	90110394
Pelvic fracture	26.41	20.91	28	510549	15191	90102679
Cutaneous T-cell lymphoma stage IV	26.38	20.91	9	510568	23	90117847
Diverticulitis	26.31	20.91	148	510429	45039	90072831
Thrombocytosis	26.29	20.91	4	510573	6997	90110873
Herpes ophthalmic	26.20	20.91	37	510540	1457	90116413
Systemic inflammatory response syndrome	26.20	20.91	3	510574	6513	90111357
Blood creatinine decreased	26.19	20.91	3	510574	6512	90111358
Helminthic infection	26.16	20.91	11	510566	58	90117812
Intervertebral disc protrusion	26.10	20.91	73	510504	27123	90090747
Haemorrhagic stroke	26.09	20.91	3	510574	6493	90111377
Serum sickness	26.01	20.91	60	510517	3482	90114388
Polyuria	25.96	20.91	12	510565	10028	90107842
Coronary artery occlusion	25.83	20.91	8	510569	8546	90109324
Exposure to fungus	25.77	20.91	16	510561	210	90117660
Diarrhoea haemorrhagic	25.68	20.91	14	510563	10649	90107221
Sickle cell anaemia with crisis	25.58	20.91	5	510572	7292	90110578
Neurological symptom	25.51	20.91	4	510573	6843	90111027
Erythema multiforme	25.49	20.91	19	510558	12227	90105643
Inflammatory marker increased	25.44	20.91	10	510567	9204	90108666
Atrioventricular block	25.29	20.91	9	510568	8806	90109064
Blood chloride decreased	25.18	20.91	3	510574	6316	90111554
Blood thyroid stimulating hormone increased	25.17	20.91	10	510567	9145	90108725
Allergy to arthropod bite	25.13	20.91	21	510556	449	90117421
Muscle atrophy	25.11	20.91	8	510569	8393	90109477
Conjunctival papillae	25.11	20.91	6	510571	0	90117870
Nasal inflammation	25.05	20.91	25	510552	677	90117193
Sleep apnoea syndrome	25.04	20.91	93	510484	31654	90086216
Erythema nodosum	24.94	20.91	80	510497	5644	90112226
Lung neoplasm malignant	24.93	20.91	63	510514	24210	90093660
Allergy to metals	24.86	20.91	30	510547	1010	90116860
Injection site coldness	24.71	20.91	12	510565	93	90117777
Erysipelas	24.71	20.91	10	510567	9042	90108828
Rhinalgia	24.70	20.91	48	510529	2470	90115400
Blood pressure inadequately controlled	24.69	20.91	3	510574	6221	90111649
Pneumothorax	24.48	20.91	44	510533	19123	90098747
Skin odour abnormal	24.46	20.91	40	510537	1795	90116075
Hyperaesthesia teeth	24.31	20.91	45	510532	2232	90115638
Stillbirth	24.27	20.91	6	510571	7437	90110433
Discharge	24.26	20.91	39	510538	1725	90116145
Head injury	24.19	20.91	92	510485	31096	90086774
Nasal oedema	24.19	20.91	4	510573	6580	90111290
Spinal pain	24.16	20.91	32	510545	15735	90102135
Paraesthesia oral	24.16	20.91	94	510483	31565	90086305
Electrocardiogram abnormal	24.12	20.91	14	510563	10284	90107586
Hepatic cyst	24.11	20.91	4	510573	6564	90111306
Generalised oedema	24.10	20.91	44	510533	19009	90098861
Infective pulmonary exacerbation of cystic fibrosis	24.03	20.91	14	510563	10265	90107605
Protein urine present	24.03	20.91	5	510572	6979	90110891
Seasonal allergy	24.03	20.91	216	510361	22767	90095103
Antinuclear antibody positive	23.96	20.91	11	510566	9230	90108640
Blood creatine increased	23.95	20.91	5	510572	6962	90110908
Allergy to arthropod sting	23.93	20.91	17	510560	283	90117587
Nocturia	23.93	20.91	14	510563	10241	90107629
Gallbladder operation	23.81	20.91	50	510527	2721	90115149
Throat clearing	23.80	20.91	61	510516	3786	90114084
Tongue disorder	23.72	20.91	16	510561	10844	90107026
Joint injury	23.66	20.91	99	510478	32565	90085305
Device failure	23.61	20.91	5	510572	6892	90110978
Erythrodermic atopic dermatitis	23.57	20.91	8	510569	20	90117850
Abdominal operation	23.54	20.91	28	510549	928	90116942
Therapy cessation	23.46	20.91	115	510462	36246	90081624
Wrong product administered	23.45	20.91	7	510570	7658	90110212
Impetigo	23.45	20.91	36	510541	1530	90116340
Thinking abnormal	23.41	20.91	19	510558	11713	90106157
Maternal exposure timing unspecified	23.37	20.91	58	510519	22425	90095445
Odynophagia	23.35	20.91	107	510470	8936	90108934
Eye colour change	23.35	20.91	19	510558	391	90117479
Humerus fracture	23.35	20.91	13	510564	9772	90108098
Restless legs syndrome	23.33	20.91	58	510519	22412	90095458
Orthopnoea	23.30	20.91	5	510572	6830	90111040
Herpes virus infection	23.22	20.91	84	510493	6300	90111570
Injection site joint pain	23.14	20.91	7	510570	10	90117860
Gallbladder disorder	23.09	20.91	48	510529	19755	90098115
Hyperaesthesia	23.07	20.91	16	510561	10686	90107184
Epigastric discomfort	22.99	20.91	7	510570	7561	90110309
Carotid artery occlusion	22.97	20.91	4	510573	6338	90111532
Vitiligo	22.90	20.91	42	510535	2068	90115802
Essential hypertension	22.84	20.91	4	510573	6311	90111559
Genital rash	22.84	20.91	23	510554	630	90117240
Rebound nasal congestion	22.82	20.91	9	510568	39	90117831
Insurance issue	22.81	20.91	17	510560	10941	90106929
Stress fracture	22.72	20.91	10	510567	8601	90109269
Arthropod sting	22.57	20.91	32	510545	1265	90116605
Neutrophilia	22.40	20.91	3	510574	5775	90112095
Multiple fractures	22.39	20.91	13	510564	9549	90108321
Acarodermatitis	22.37	20.91	33	510544	1353	90116517
Emotional disorder	22.35	20.91	153	510424	14844	90103026
Limb operation	22.26	20.91	66	510511	4461	90113409
Milia	22.22	20.91	13	510564	152	90117718
Necrosis	22.20	20.91	5	510572	6605	90111265
Escherichia bacteraemia	22.18	20.91	3	510574	5732	90112138
Glassy eyes	22.15	20.91	11	510566	90	90117780
Pollakiuria	22.11	20.91	103	510474	32902	90084968
Hyperphagia	22.10	20.91	49	510528	2769	90115101
Wisdom teeth removal	22.02	20.91	24	510553	722	90117148
Heart rate irregular	21.94	20.91	67	510510	24201	90093669
Ovarian cyst	21.90	20.91	40	510537	17278	90100592
Blood glucose decreased	21.67	20.91	64	510513	23365	90094505
Eyelid disorder	21.61	20.91	42	510535	2161	90115709
Hepatic enzyme abnormal	21.59	20.91	8	510569	7634	90110236
Organising pneumonia	21.38	20.91	8	510569	7589	90110281
Nasal flaring	21.36	20.91	7	510570	15	90117855
Peripheral vascular disorder	21.33	20.91	5	510572	6426	90111444
Bronchospasm	21.07	20.91	54	510523	20655	90097215
Meningitis aseptic	21.06	20.91	6	510571	6767	90111103
Drug specific antibody present	21.05	20.91	3	510574	5511	90112359
Fibrosis	21.03	20.91	4	510573	5948	90111922
Pseudomonas infection	20.96	20.91	32	510545	14833	90103037
Sunscreen sensitivity	20.92	20.91	5	510572	0	90117870
Eczema infantile	20.92	20.91	5	510572	0	90117870

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pruritus	26863.95	32.57	16589	286323	172182	42146241
Injection site pain	17480.14	32.57	8404	294508	49394	42269029
Dry skin	17345.60	32.57	7912	295000	40426	42277997
Product use in unapproved indication	15199.45	32.57	11609	291303	172847	42145576
Eczema	12957.04	32.57	5814	297098	28272	42290151
Product dose omission in error	8731.34	32.57	2972	299940	5382	42313041
Inappropriate schedule of product administration	8647.13	32.57	6390	296522	89512	42228911
Rash	8238.11	32.57	9944	292968	267010	42051413
Exposure via skin contact	8109.71	32.57	2488	300424	2550	42315873
Dry eye	7584.08	32.57	3164	299748	12342	42306081
Skin exfoliation	7364.23	32.57	4235	298677	37318	42281105
Injection site swelling	7295.28	32.57	3160	299752	13813	42304610
Therapeutic response shortened	6956.89	32.57	2863	300049	10691	42307732
Product dose omission issue	6293.05	32.57	6546	296366	147819	42170604
Accidental exposure to product	5787.66	32.57	2847	300065	17546	42300877
Eye pruritus	5603.52	32.57	2336	300576	9076	42309347
Skin fissures	5500.33	32.57	2200	300712	7476	42310947
Incorrect dose administered	5434.54	32.57	3823	299089	49151	42269272
Ocular hyperaemia	4577.52	32.57	2245	300667	13718	42304705
Therapeutic response decreased	4438.87	32.57	2943	299969	34069	42284354
Sleep disorder due to a general medical condition	4326.83	32.57	2224	300688	15229	42303194
Skin burning sensation	3841.52	32.57	1582	301330	5905	42312518
Injection site erythema	3625.46	32.57	2078	300834	18117	42300306
Eye irritation	3571.31	32.57	1700	301212	9618	42308805
Erythema	3189.01	32.57	3893	299019	104900	42213523
Condition aggravated	3031.43	32.57	6084	296828	254670	42063753
Conjunctivitis	3020.30	32.57	1584	301328	11355	42307068
Rash erythematous	3018.65	32.57	2199	300713	29892	42288531
Rebound eczema	2872.21	32.57	750	302162	101	42318322
Skin haemorrhage	2820.73	32.57	1292	301620	6593	42311830
Rebound atopic dermatitis	2681.14	32.57	729	302183	235	42318188
Acute kidney injury	2475.93	32.57	26	302886	367311	41951112
Injection site pruritus	2314.04	32.57	1193	301719	8212	42310211
Arthralgia	2305.00	32.57	4725	298187	200513	42117910
Product preparation error	2276.84	32.57	958	301954	3820	42314603
Impaired quality of life	2153.42	32.57	1310	301602	12867	42305556
Injection site urticaria	2074.55	32.57	813	302099	2570	42315853
Rash macular	2012.92	32.57	1339	301573	15552	42302871
Death	1953.91	32.57	478	302434	470707	41847716
Nasal congestion	1874.65	32.57	1605	301307	27896	42290527
Rebound effect	1818.07	32.57	937	301975	6442	42311981
Drug ineffective	1776.21	32.57	8975	293937	621222	41697201
Skin swelling	1763.86	32.57	689	302223	2153	42316270
Anaemia	1727.99	32.57	60	302852	280218	42038205
Drug interaction	1716.70	32.57	38	302874	266961	42051462
Injection site rash	1716.37	32.57	830	302082	4882	42313541
Skin weeping	1637.44	32.57	559	302353	1020	42317403
Injection site bruising	1618.10	32.57	1013	301899	10512	42307911
Discomfort	1608.19	32.57	1375	301537	23844	42294579
Toxicity to various agents	1598.92	32.57	5	302907	229131	42089292
Intentional dose omission	1596.61	32.57	919	301993	8067	42310356
Scratch	1546.24	32.57	753	302159	4508	42313915
Sleep disorder	1527.31	32.57	1795	301117	46300	42272123
Skin irritation	1427.31	32.57	805	302107	6769	42311654
Lacrimation increased	1410.14	32.57	936	301976	10822	42307601
Hypotension	1375.28	32.57	125	302787	257506	42060917
Illness	1373.21	32.57	1251	301661	23679	42294744
Febrile neutropenia	1289.78	32.57	5	302907	185698	42132725
Neutropenia	1274.89	32.57	30	302882	199401	42119022
Vision blurred	1257.26	32.57	1722	301190	51977	42266446
Rhinorrhoea	1239.54	32.57	1321	301591	30473	42287950
Injection site reaction	1219.89	32.57	961	301951	14760	42303663
Thrombocytopenia	1214.80	32.57	29	302883	190250	42128173
Product prescribing issue	1158.89	32.57	676	302236	6097	42312326
Injection site mass	1109.69	32.57	716	302196	7859	42310564
Drug effect less than expected	1046.94	32.57	523	302389	3334	42315089
Sepsis	998.30	32.57	122	302790	199212	42119211
Oral herpes	986.29	32.57	634	302278	6910	42311513
Diarrhoea	963.33	32.57	1118	301794	459731	41858692
Dermatitis atopic	938.18	32.57	747	302165	11657	42306766
Pneumonia	926.01	32.57	984	301928	421165	41897258
Eye discharge	917.25	32.57	441	302471	2554	42315869
Product use issue	912.70	32.57	1813	301099	74938	42243485
Nasopharyngitis	906.49	32.57	1906	301006	82090	42236333
Disease progression	869.52	32.57	35	302877	143621	42174802
Rash pruritic	866.46	32.57	1130	301782	32473	42285950
Nausea	848.82	32.57	944	301968	395855	41922568
Confusional state	842.87	32.57	101	302811	167496	42150927
Cough	821.64	32.57	2956	299956	175147	42143276
Product storage error	819.33	32.57	660	302252	10480	42307943
Renal failure	810.26	32.57	54	302858	143672	42174751
Extra dose administered	807.46	32.57	503	302409	5166	42313257
Pancytopenia	807.35	32.57	5	302907	117738	42200685
Platelet count decreased	790.32	32.57	49	302863	138532	42179891
Haemoglobin decreased	786.08	32.57	37	302875	132434	42185989
Anosmia	779.81	32.57	476	302436	4700	42313723
Respiratory failure	776.14	32.57	31	302881	128101	42190322
Malignant neoplasm progression	751.73	32.57	3	302909	108397	42210026
Injection site vesicles	742.11	32.57	298	302614	1022	42317401
Asthenia	697.29	32.57	584	302328	280209	42038214
Blood creatinine increased	696.88	32.57	18	302894	109985	42208438
Eyelid margin crusting	696.03	32.57	233	302679	387	42318036
Overdose	695.87	32.57	10	302902	105254	42213169
Hyponatraemia	677.93	32.57	8	302904	101454	42216969
Cardiac arrest	670.43	32.57	24	302888	109296	42209127
Lack of injection site rotation	670.15	32.57	218	302694	313	42318110
General physical health deterioration	667.56	32.57	132	302780	151114	42167309
Multiple organ dysfunction syndrome	655.94	32.57	6	302906	97029	42221394
Eyelids pruritus	636.34	32.57	190	302722	160	42318263
Fear of injection	634.89	32.57	302	302610	1701	42316722
Oedema peripheral	634.66	32.57	103	302809	135973	42182450
Injection site discomfort	624.60	32.57	314	302598	2032	42316391
White blood cell count decreased	620.55	32.57	42	302870	110354	42208069
Pulmonary embolism	619.00	32.57	65	302847	119547	42198876
Completed suicide	617.85	32.57	14	302898	96451	42221972
Erythema of eyelid	606.40	32.57	268	302644	1235	42317188
Vomiting	604.73	32.57	702	302210	289021	42029402
Dehydration	604.47	32.57	134	302778	141633	42176790
Periorbital swelling	594.80	32.57	267	302645	1286	42317137
Septic shock	592.26	32.57	12	302900	91660	42226763
Renal impairment	591.24	32.57	52	302860	110176	42208247
Abdominal pain	588.55	32.57	310	302602	190161	42128262
Eyelid skin dryness	583.20	32.57	171	302741	125	42318298
Injection site irritation	577.16	32.57	267	302645	1397	42317026
Eye pain	574.21	32.57	656	302256	16374	42302049
Gastrointestinal haemorrhage	564.79	32.57	32	302880	97694	42220729
Skin discomfort	559.68	32.57	207	302705	529	42317894
Skin discolouration	543.82	32.57	706	302206	20184	42298239
Alanine aminotransferase increased	543.45	32.57	19	302893	88387	42230036
Hypertension	536.18	32.57	259	302653	166945	42151478
Fall	527.06	32.57	534	302378	233986	42084437
Eye swelling	525.00	32.57	529	302383	11391	42307032
Tachycardia	520.26	32.57	56	302856	101031	42217392
Cardiac failure	518.59	32.57	72	302840	106784	42211639
Bradycardia	516.45	32.57	21	302891	85463	42232960
Hyperkalaemia	513.97	32.57	12	302900	80446	42237977
Pleural effusion	509.97	32.57	50	302862	97116	42221307
Atrial fibrillation	500.85	32.57	183	302729	139410	42179013
Seizure	490.18	32.57	126	302786	120435	42197988
Leukopenia	485.97	32.57	9	302903	74737	42243686
Hypokalaemia	482.02	32.57	5	302907	71716	42246707
Eye disorder	479.95	32.57	498	302414	11114	42307309
Aspartate aminotransferase increased	472.81	32.57	17	302895	77146	42241277
Rhabdomyolysis	471.86	32.57	19	302893	78000	42240423
Device use issue	467.88	32.57	197	302715	786	42317637
Food allergy	467.56	32.57	254	302658	1967	42316456
Constipation	465.66	32.57	289	302623	162002	42156421
Dermatitis	465.35	32.57	495	302417	11380	42307043
Interstitial lung disease	458.61	32.57	24	302888	78438	42239985
Sneezing	444.72	32.57	366	302546	5997	42312426
Blepharitis	440.41	32.57	233	302679	1700	42316723
Decreased appetite	436.91	32.57	437	302475	192700	42125723
Swelling of eyelid	427.63	32.57	236	302676	1892	42316531
COVID-19	407.94	32.57	1769	301143	114179	42204244
Deep vein thrombosis	405.37	32.57	39	302873	76918	42241505
Cardio-respiratory arrest	399.21	32.57	3	302909	58633	42259790
Neutrophil count decreased	391.91	32.57	13	302899	63402	42255021
Acne	391.34	32.57	484	302428	13160	42305263
Hypoxia	382.17	32.57	30	302882	69756	42248667
Hypoglycaemia	381.97	32.57	9	302903	59845	42258578
Syncope	379.68	32.57	117	302795	99289	42219134
Somnolence	378.13	32.57	271	302641	140834	42177589
Cardiac failure congestive	376.85	32.57	75	302837	85527	42232896
Therapeutic response unexpected	367.84	32.57	429	302483	10952	42307471
Ascites	367.70	32.57	7	302905	56671	42261752
Drug intolerance	365.69	32.57	65	302847	80359	42238064
Weight decreased	358.61	32.57	578	302334	207370	42111053
Urticaria	357.75	32.57	1249	301663	72787	42245636
Nasal obstruction	357.75	32.57	164	302748	837	42317586
Pyrexia	355.60	32.57	1518	301394	392524	41925899
Neuropathy peripheral	352.78	32.57	141	302771	101712	42216711
Sinusitis	350.15	32.57	927	301985	46365	42272058
Eye inflammation	349.49	32.57	241	302671	2977	42315446
C-reactive protein increased	348.96	32.57	27	302885	63533	42254890
Injection site haemorrhage	347.39	32.57	423	302489	11313	42307110
Delirium	346.92	32.57	5	302907	52514	42265909
Acute myocardial infarction	342.39	32.57	17	302895	58148	42260275
Hypersensitivity	341.15	32.57	1211	301701	71159	42247264
Off label use of device	334.75	32.57	90	302822	24	42318399
Mucosal inflammation	333.82	32.57	3	302909	49371	42269052
Myocardial infarction	332.44	32.57	238	302674	123771	42194652
Visual impairment	330.32	32.57	856	302056	42257	42276166
Haematuria	327.59	32.57	21	302891	57778	42260645
Intentional product use issue	326.71	32.57	58	302854	71775	42246648
Hordeolum	325.59	32.57	179	302733	1423	42317000
Coronary artery disease	325.08	32.57	13	302899	53707	42264716
International normalised ratio increased	320.72	32.57	4	302908	48164	42270259
Coma	320.60	32.57	14	302898	53540	42264883
Depressed level of consciousness	319.33	32.57	4	302908	47966	42270457
Ocular discomfort	315.76	32.57	222	302690	2835	42315588
Agitation	312.73	32.57	43	302869	64271	42254152
Eyelid rash	311.37	32.57	87	302825	40	42318383
Hepatic function abnormal	310.29	32.57	13	302899	51554	42266869
Symptom recurrence	309.77	32.57	169	302743	1321	42317102
Tremor	306.15	32.57	153	302759	96776	42221647
Hallucination	303.22	32.57	29	302883	57478	42260945
Foetal exposure during pregnancy	302.32	32.57	7	302905	47304	42271119
Oropharyngeal pain	296.33	32.57	815	302097	41695	42276728
Pneumonia aspiration	293.60	32.57	15	302897	50063	42268360
Scab	292.66	32.57	279	302633	5599	42312824
Product administered at inappropriate site	290.20	32.57	212	302700	2886	42315537
Unintentional use for unapproved indication	288.71	32.57	81	302831	39	42318384
Eye infection	288.47	32.57	243	302669	4118	42314305
Rectal haemorrhage	287.26	32.57	16	302896	49590	42268833
Eczema eyelids	286.60	32.57	85	302827	68	42318355
Blood creatine phosphokinase increased	284.92	32.57	14	302898	48324	42270099
Secretion discharge	284.62	32.57	310	302602	7325	42311098
Loss of consciousness	282.43	32.57	152	302760	92202	42226221
Injection site discolouration	279.59	32.57	173	302739	1753	42316670
Pain of skin	278.69	32.57	315	302597	7765	42310658
Blood pressure decreased	276.64	32.57	42	302870	58290	42260133
Blood pressure increased	275.28	32.57	194	302718	101734	42216689
Hyperglycaemia	274.46	32.57	12	302900	45847	42272576
Plasma cell myeloma	273.50	32.57	16	302896	47562	42270861
Suicide attempt	272.85	32.57	13	302899	46087	42272336
Eyelid irritation	272.71	32.57	104	302808	298	42318125
Encephalopathy	272.71	32.57	4	302908	41329	42277094
Blood bilirubin increased	267.12	32.57	7	302905	42245	42276178
Influenza	264.87	32.57	1007	301905	61168	42257255
Drug reaction with eosinophilia and systemic symptoms	262.20	32.57	8	302904	42067	42276356
Fatigue	254.31	32.57	1934	300978	433707	41884716
Chronic kidney disease	251.25	32.57	23	302889	47218	42271205
Intercepted product storage error	250.01	32.57	96	302816	282	42318141
Therapy non-responder	249.45	32.57	40	302872	53319	42265104
Urinary tract infection	247.64	32.57	205	302707	99079	42219344
Oesophageal food impaction	242.69	32.57	80	302832	123	42318300
Hepatic failure	242.04	32.57	6	302906	38094	42280329
Ear infection	240.11	32.57	370	302542	12434	42305989
Respiratory tract congestion	239.12	32.57	284	302628	7394	42311029
Drug-induced liver injury	235.91	32.57	8	302904	38265	42280158
Melaena	235.70	32.57	9	302903	38737	42279686
Skin disorder	232.80	32.57	426	302486	16518	42301905
Haematochezia	231.82	32.57	64	302848	58372	42260051
Blister	230.58	32.57	565	302347	26925	42291498
Suicidal ideation	227.63	32.57	35	302877	48126	42270297
Drug resistance	223.06	32.57	4	302908	34244	42284179
Blood glucose increased	222.83	32.57	123	302789	73576	42244847
Blood urea increased	217.09	32.57	3	302909	32790	42285633
Hyposmia	216.57	32.57	86	302826	284	42318139
Treatment failure	216.27	32.57	87	302825	62537	42255886
Respiratory distress	215.49	32.57	23	302889	41797	42276626
Pharyngitis streptococcal	215.15	32.57	196	302716	3704	42314719
Jaundice	214.01	32.57	7	302905	34582	42283841
Transaminases increased	213.53	32.57	4	302908	32881	42285542
Muscular weakness	212.46	32.57	169	302743	83329	42235094
Oxygen saturation decreased	212.03	32.57	97	302815	64590	42253833
Acute respiratory failure	211.88	32.57	17	302895	38841	42279582
Initial insomnia	211.57	32.57	197	302715	3833	42314590
Medication error	211.45	32.57	5	302907	33149	42285274
Dysarthria	210.04	32.57	20	302892	39787	42278636
Cytomegalovirus infection	209.48	32.57	4	302908	32302	42286121
Urinary retention	208.12	32.57	27	302885	42187	42276236
Neurodermatitis	207.13	32.57	105	302807	693	42317730
Pulmonary oedema	206.41	32.57	61	302851	53211	42265212
Oedema	206.19	32.57	57	302855	51944	42266479
Periorbital irritation	205.89	32.57	55	302857	13	42318410
Sensitive skin	202.37	32.57	120	302792	1118	42317305
Aggression	202.22	32.57	35	302877	44128	42274295
Angioedema	200.45	32.57	31	302881	42446	42275977
Blood alkaline phosphatase increased	200.36	32.57	9	302903	33588	42284835
Haemoptysis	197.86	32.57	43	302869	46124	42272299
Gamma-glutamyltransferase increased	196.14	32.57	8	302904	32489	42285934
Cholestasis	195.45	32.57	9	302903	32870	42285553
Malaise	194.67	32.57	811	302101	211345	42107078
Acute respiratory distress syndrome	194.13	32.57	4	302908	30104	42288319
Orthostatic hypotension	193.48	32.57	5	302907	30565	42287858
Rash maculo-papular	192.28	32.57	21	302891	37482	42280941
Thrombosis	192.16	32.57	125	302787	68386	42250037
Liver function test abnormal	192.11	32.57	9	302903	32382	42286041
Pneumonitis	191.16	32.57	33	302879	41685	42276738
Cerebral haemorrhage	189.53	32.57	26	302886	38940	42279483
Colitis	188.52	32.57	49	302863	46523	42271900
Ventricular tachycardia	186.97	32.57	6	302906	30154	42288269
Arrhythmia	186.70	32.57	31	302881	40286	42278137
Diabetes mellitus	186.45	32.57	97	302815	59990	42258433
Tubulointerstitial nephritis	186.35	32.57	9	302903	31539	42286884
Injection site warmth	184.71	32.57	153	302759	2530	42315893
Nasal polyps	184.56	32.57	179	302733	3672	42314751
Psychotic disorder	184.02	32.57	5	302907	29203	42289220
Altered state of consciousness	180.74	32.57	6	302906	29253	42289170
Red blood cell count decreased	179.25	32.57	14	302898	32701	42285722
Cerebrovascular accident	177.85	32.57	259	302653	96901	42221522
Disorientation	177.65	32.57	24	302888	36365	42282058
Surgery	176.18	32.57	388	302524	17228	42301195
Unresponsive to stimuli	176.18	32.57	12	302900	31391	42287032
Eye allergy	175.55	32.57	57	302855	81	42318342
Respiratory arrest	174.98	32.57	6	302906	28418	42290005
Toxic epidermal necrolysis	174.72	32.57	3	302909	26747	42291676
Sinus disorder	174.48	32.57	249	302663	7801	42310622
Lymphocyte count decreased	174.32	32.57	5	302907	27804	42290619
Shock	173.01	32.57	8	302904	29113	42289310
Hypothyroidism	172.28	32.57	15	302897	32069	42286354
Cerebral infarction	171.73	32.57	13	302899	31156	42287267
Upper-airway cough syndrome	171.04	32.57	182	302730	4184	42314239
Liver disorder	169.74	32.57	37	302875	39607	42278816
Drug dependence	169.63	32.57	9	302903	29085	42289338
Hepatitis	167.22	32.57	6	302906	27294	42291129
Angina pectoris	167.18	32.57	19	302893	32877	42285546
Depression	167.07	32.57	337	302575	111026	42207397
Eyelid exfoliation	165.08	32.57	45	302867	15	42318408
Pancreatitis acute	164.18	32.57	22	302890	33542	42284881
Cognitive disorder	161.10	32.57	25	302887	34147	42284276
Pneumocystis jirovecii pneumonia	159.81	32.57	4	302908	25177	42293246
Blood pressure systolic increased	158.93	32.57	10	302902	27958	42290465
Blood pressure fluctuation	157.90	32.57	8	302904	26900	42291523
Paranasal sinus discomfort	157.42	32.57	101	302811	1096	42317327
Chills	156.74	32.57	267	302645	93799	42224624
Hepatic enzyme increased	155.81	32.57	65	302847	45719	42272704
Abdominal distension	155.52	32.57	168	302744	71567	42246856
Full blood count abnormal	155.03	32.57	16	302896	29860	42288563
Hepatic cytolysis	154.35	32.57	9	302903	26835	42291588
Sinus operation	152.83	32.57	88	302824	772	42317651
Hepatotoxicity	152.54	32.57	6	302906	25161	42293262
Hypophagia	152.11	32.57	10	302902	26946	42291477
Haematemesis	152.08	32.57	18	302894	30181	42288242
Bacteraemia	151.67	32.57	6	302906	25034	42293389
Generalised tonic-clonic seizure	151.20	32.57	9	302903	26370	42292053
Accidental overdose	150.08	32.57	14	302898	28316	42290107
Injection site inflammation	148.06	32.57	95	302817	1031	42317392
Superficial injury of eye	148.03	32.57	47	302865	59	42318364
Cellulitis	146.42	32.57	133	302779	61452	42256971
Haematoma	145.43	32.57	15	302897	28008	42290415
Pancreatitis	144.73	32.57	63	302849	43205	42275218
Acute myeloid leukaemia	139.50	32.57	4	302908	22252	42296171
Pulmonary fibrosis	139.19	32.57	14	302898	26667	42291756
Burning sensation	136.70	32.57	393	302519	20620	42297803
Heart rate decreased	135.84	32.57	45	302867	36487	42281936
Chest pain	135.69	32.57	521	302391	139009	42179414
Hand dermatitis	135.54	32.57	58	302854	243	42318180
Coagulopathy	135.30	32.57	5	302907	22157	42296266
Pulmonary hypertension	135.22	32.57	8	302904	23561	42294862
Intestinal obstruction	134.76	32.57	17	302895	27141	42291282
Rheumatoid arthritis	133.91	32.57	67	302845	42373	42276050
Myelodysplastic syndrome	132.71	32.57	7	302905	22738	42295685
Stevens-Johnson syndrome	132.05	32.57	6	302906	22172	42296251
Ejection fraction decreased	131.43	32.57	6	302906	22081	42296342
Musculoskeletal pain	131.31	32.57	37	302875	33303	42285120
Benign prostatic hyperplasia	131.17	32.57	4	302908	21048	42297375
Drug withdrawal syndrome	131.08	32.57	5	302907	21544	42296879
White blood cell count increased	130.91	32.57	79	302833	45008	42273415
Hyperlipidaemia	130.85	32.57	5	302907	21511	42296912
Hand-foot-and-mouth disease	129.34	32.57	56	302856	243	42318180
Clostridium difficile colitis	129.03	32.57	5	302907	21247	42297176
Anaphylactic shock	129.02	32.57	10	302902	23507	42294916
Injection site dryness	127.37	32.57	37	302875	25	42318398
Eosinophilic oesophagitis	126.91	32.57	73	302839	639	42317784
Hypervolaemia	126.40	32.57	10	302902	23115	42295308
Ischaemic stroke	126.18	32.57	8	302904	22225	42296198
Proteinuria	125.45	32.57	10	302902	22973	42295450
Laboratory test abnormal	125.41	32.57	10	302902	22968	42295455
Circulatory collapse	124.36	32.57	12	302900	23624	42294799
Diabetic ketoacidosis	124.16	32.57	9	302903	22358	42296065
Foreign body sensation in eyes	124.16	32.57	80	302832	875	42317548
Device defective	124.06	32.57	100	302812	1588	42316835
Dyskinesia	123.33	32.57	17	302895	25373	42293050
Dysphagia	123.05	32.57	912	302000	71807	42246616
Tachypnoea	122.33	32.57	8	302904	21654	42296769
Liver injury	121.67	32.57	3	302909	19145	42299278
Pallor	121.56	32.57	28	302884	28858	42289565
Epilepsy	121.44	32.57	20	302892	26151	42292272
Full blood count decreased	121.00	32.57	6	302906	20554	42297869
Stomatitis	120.46	32.57	108	302804	50221	42268202
Hallucination, visual	118.01	32.57	8	302904	21012	42297411
Nasal polypectomy	117.89	32.57	32	302880	10	42318413
Wrong technique in device usage process	117.08	32.57	120	302792	2637	42315786
Eosinophil count increased	116.73	32.57	245	302667	10518	42307905
Lymphopenia	115.99	32.57	10	302902	21553	42296870
Device related infection	115.98	32.57	7	302905	20272	42298151
Neutrophil count increased	115.85	32.57	6	302906	19798	42298625
Miliaria	115.39	32.57	67	302845	598	42317825
Disease recurrence	114.92	32.57	34	302878	29644	42288779
Lower respiratory tract infection	114.41	32.57	76	302836	41130	42277293
Product quality issue	112.88	32.57	3	302909	17879	42300544
Sinus tachycardia	112.69	32.57	9	302903	20644	42297779
Leukocytosis	111.50	32.57	36	302876	29672	42288751
Polyneuropathy	111.26	32.57	5	302907	18656	42299767
Toothache	110.99	32.57	196	302716	7387	42311036
Respiration abnormal	110.48	32.57	140	302772	3902	42314521
Clostridium difficile infection	110.47	32.57	15	302897	22644	42295779
Cholelithiasis	110.23	32.57	17	302895	23329	42295094
Drug effective for unapproved indication	109.68	32.57	181	302731	6452	42311971
Palmar-plantar erythrodysaesthesia syndrome	109.48	32.57	10	302902	20572	42297851
Restlessness	108.80	32.57	36	302876	29213	42289210
Dysgeusia	107.83	32.57	54	302858	34135	42284288
Atelectasis	106.87	32.57	8	302904	19353	42299070
Treatment noncompliance	106.61	32.57	68	302844	37604	42280819
Ocular surface disease	104.89	32.57	37	302875	78	42318345
Spinal operation	104.18	32.57	139	302773	4081	42314342
Basal cell carcinoma	104.10	32.57	18	302894	22715	42295708
Inappropriate antidiuretic hormone secretion	103.57	32.57	3	302909	16538	42301885
Injury associated with device	103.18	32.57	83	302829	1314	42317109
Therapy partial responder	103.16	32.57	11	302901	20010	42298413
Facial discomfort	103.15	32.57	35	302877	62	42318361
Dysuria	102.85	32.57	46	302866	31050	42287373
Asthenopia	102.24	32.57	68	302844	788	42317635
Pericardial effusion	102.15	32.57	40	302872	29235	42289188
Troponin increased	102.10	32.57	9	302903	19053	42299370
Nephropathy toxic	102.10	32.57	4	302908	16834	42301589
Appendicitis	102.04	32.57	13	302899	20600	42297823
Splenomegaly	100.24	32.57	5	302907	17042	42301381
End stage renal disease	100.17	32.57	4	302908	16554	42301869
Abnormal behaviour	99.37	32.57	32	302880	26419	42292004
Metastases to liver	98.58	32.57	4	302908	16322	42302101
Obstructive airways disorder	98.39	32.57	27	302885	24732	42293691
Nightmare	98.05	32.57	28	302884	24984	42293439
Electrolyte imbalance	97.51	32.57	6	302906	17095	42301328
Sudden death	97.39	32.57	5	302907	16624	42301799
Anxiety	97.30	32.57	472	302440	118088	42200335
Small intestinal obstruction	97.24	32.57	6	302906	17055	42301368
Dandruff	96.92	32.57	47	302865	278	42318145
Mitral valve incompetence	96.44	32.57	5	302907	16484	42301939
Osteoarthritis	96.26	32.57	27	302885	24378	42294045
Blood albumin decreased	95.69	32.57	3	302909	15399	42303024
Cardiomyopathy	95.37	32.57	12	302900	19198	42299225
Arteriosclerosis	94.99	32.57	9	302903	17980	42300443
COVID-19 pneumonia	94.93	32.57	19	302893	21594	42296829
Nasal dryness	94.79	32.57	79	302833	1318	42317105
Skin texture abnormal	94.34	32.57	30	302882	38	42318385
Intentional self-injury	94.31	32.57	3	302909	15199	42303224
Ataxia	93.96	32.57	5	302907	16120	42302303
Hemiparesis	93.62	32.57	8	302904	17368	42301055
Liver function test increased	93.42	32.57	15	302897	19983	42298440
Urinary incontinence	93.20	32.57	20	302892	21648	42296775
Middle insomnia	92.87	32.57	185	302727	7648	42310775
Dizziness	92.52	32.57	1232	301680	248022	42070401
Oropharyngeal discomfort	92.37	32.57	130	302782	4019	42314404
Acute coronary syndrome	91.98	32.57	3	302909	14862	42303561
Lethargy	91.78	32.57	119	302793	46771	42271652
Sunburn	91.53	32.57	93	302819	2022	42316401
Throat clearing	91.03	32.57	56	302856	561	42317862
Blood potassium increased	91.01	32.57	12	302900	18524	42299899
Wheezing	90.93	32.57	684	302228	54097	42264326
Speech disorder	90.33	32.57	47	302865	29074	42289349
Atrial flutter	90.12	32.57	9	302903	17242	42301181
Hepatic steatosis	89.83	32.57	21	302891	21427	42296996
Palpitations	89.43	32.57	139	302773	50658	42267765
Subarachnoid haemorrhage	89.27	32.57	3	302909	14469	42303954
Aspergillus infection	88.98	32.57	6	302906	15831	42302592
Cutaneous T-cell lymphoma	88.56	32.57	89	302823	1909	42316514
Metastases to bone	88.19	32.57	4	302908	14805	42303618
Balance disorder	87.14	32.57	127	302785	47518	42270905
Periorbital pain	87.02	32.57	26	302886	22	42318401
Pustule	86.98	32.57	70	302842	1109	42317314
Brain oedema	86.66	32.57	8	302904	16319	42302104
Malnutrition	86.36	32.57	4	302908	14538	42303885
Osteonecrosis	86.32	32.57	7	302905	15858	42302565
Pneumothorax	85.79	32.57	30	302882	23513	42294910
Hallucination, auditory	85.40	32.57	5	302907	14859	42303564
Perioral dermatitis	85.39	32.57	39	302873	197	42318226
Blood potassium decreased	85.29	32.57	20	302892	20364	42298059
Sensitivity to weather change	85.09	32.57	88	302824	1955	42316468
Asthma	84.98	32.57	744	302168	61570	42256853
Cardiomegaly	84.40	32.57	10	302902	16756	42301667
Synovitis	84.33	32.57	7	302905	15560	42302863
Glomerular filtration rate decreased	84.20	32.57	9	302903	16342	42302081
Rosacea	83.90	32.57	73	302839	1295	42317128
Underdose	83.75	32.57	10	302902	16656	42301767
Cardiac failure acute	83.48	32.57	3	302909	13630	42304793
Diabetes mellitus inadequate control	83.15	32.57	7	302905	15383	42303040
Adverse event	82.98	32.57	32	302880	23608	42294815
Paranoia	82.84	32.57	4	302908	14022	42304401
Myasthenia gravis	82.80	32.57	9	302903	16128	42302295
Injection site nodule	82.74	32.57	89	302823	2072	42316351
Contraindicated product administered	82.62	32.57	38	302874	25234	42293189
Transient ischaemic attack	82.42	32.57	71	302841	33668	42284755
Aphasia	82.24	32.57	34	302878	24049	42294374
Lung disorder	80.73	32.57	135	302777	47788	42270635
Hepatic cirrhosis	79.20	32.57	21	302891	19681	42298742
Nasal operation	79.08	32.57	33	302879	128	42318295
Cholecystitis	79.04	32.57	3	302909	12985	42305438
Alopecia	78.97	32.57	414	302498	28862	42289561
Myocarditis	78.42	32.57	19	302893	18919	42299504
Keratitis	77.96	32.57	79	302833	1712	42316711
Toxic skin eruption	77.74	32.57	5	302907	13725	42304698
Body temperature decreased	76.67	32.57	7	302905	14406	42304017
Chronic obstructive pulmonary disease	76.27	32.57	214	302698	62900	42255523
Hyperthermia	76.19	32.57	3	302909	12571	42305852
Aspiration	75.94	32.57	17	302895	17869	42300554
Prostate cancer	75.91	32.57	125	302787	44518	42273905
Gait disturbance	74.80	32.57	400	302512	97600	42220823
Sinus congestion	74.66	32.57	158	302754	6822	42311601
Myositis	74.50	32.57	9	302903	14857	42303566
Anaphylactic reaction	74.25	32.57	118	302794	42625	42275798
Blood uric acid increased	74.13	32.57	11	302901	15536	42302887
Mood disorder due to a general medical condition	73.87	32.57	20	302892	6	42318417
Nervous system disorder	73.69	32.57	16	302896	17179	42301244
Blood cholesterol increased	73.32	32.57	50	302862	26691	42291732
Urosepsis	73.09	32.57	10	302902	15010	42303413
Joint stiffness	73.04	32.57	223	302689	12099	42306324
Periorbital inflammation	72.99	32.57	27	302885	69	42318354
Ventricular extrasystoles	72.59	32.57	6	302906	13384	42305039
Injection site hypoaesthesia	71.97	32.57	30	302882	116	42318307
Eyelid pain	71.96	32.57	32	302880	150	42318273
Amnesia	71.73	32.57	58	302854	28379	42290044
Mental status changes	71.53	32.57	118	302794	41997	42276426
Cardiac murmur	71.31	32.57	5	302907	12770	42305653
Heart rate increased	70.90	32.57	172	302740	53083	42265340
Paternal exposure during pregnancy	70.84	32.57	28	302884	91	42318332
Fluid retention	70.81	32.57	72	302840	31547	42286876
Gastric ulcer	70.56	32.57	21	302891	18241	42300182
Haemolytic anaemia	69.92	32.57	4	302908	12123	42306300
Productive cough	69.43	32.57	614	302298	50953	42267470
Psoriatic arthropathy	69.37	32.57	46	302866	24921	42293502
Pigmentation disorder	69.14	32.57	98	302814	3050	42315373
Body temperature increased	69.10	32.57	29	302883	20329	42298094
Cyanosis	68.61	32.57	12	302900	15019	42303404
Presyncope	68.16	32.57	37	302875	22350	42296073
Drainage	68.05	32.57	23	302889	40	42318383
Disturbance in attention	68.04	32.57	67	302845	29799	42288624
Blood triglycerides increased	67.70	32.57	15	302897	15881	42302542
Bacterial infection	67.70	32.57	59	302853	27820	42290603
Haemorrhage	67.66	32.57	213	302699	60350	42258073
Gastroenteritis	67.14	32.57	17	302895	16432	42301991
Skin atrophy	66.72	32.57	86	302826	2439	42315984
Muscle rigidity	66.51	32.57	5	302907	12054	42306369
Hyperthyroidism	66.45	32.57	11	302901	14330	42304093
Allergy to animal	66.43	32.57	44	302868	506	42317917
Ear discomfort	66.23	32.57	100	302812	3299	42315124
Tricuspid valve incompetence	66.18	32.57	3	302909	11110	42307313
Pseudomonas infection	65.88	32.57	16	302896	15907	42302516
Adrenal insufficiency	65.78	32.57	26	302886	18898	42299525
Osteoporosis	65.68	32.57	13	302899	14893	42303530
Staphylococcal sepsis	65.09	32.57	4	302908	11410	42307013
Osteomyelitis	65.07	32.57	24	302888	18199	42300224
Type 2 diabetes mellitus	64.83	32.57	25	302887	18446	42299977
Pharyngeal swelling	64.64	32.57	99	302813	3308	42315115
Blepharospasm	64.46	32.57	63	302849	1305	42317118
Prostatic specific antigen increased	64.42	32.57	20	302892	16905	42301518
SARS-CoV-2 test positive	64.24	32.57	165	302747	8095	42310328
Myalgia	63.36	32.57	997	301915	95083	42223340
Visual acuity reduced	62.86	32.57	23	302889	17527	42300896
Lipase increased	62.44	32.57	3	302909	10563	42307860
Metastases to lung	62.26	32.57	5	302907	11419	42307004
Chapped lips	62.24	32.57	53	302859	912	42317511
Drug eruption	62.13	32.57	44	302868	23031	42295392
Rales	62.10	32.57	5	302907	11395	42307028
Hospitalisation	62.07	32.57	804	302108	73526	42244897
Hepatomegaly	61.95	32.57	6	302906	11779	42306644
Haemorrhoids	61.93	32.57	22	302890	17075	42301348
Frequent bowel movements	61.45	32.57	38	302874	21369	42297054
Injection site discharge	61.00	32.57	41	302871	484	42317939
Withdrawal syndrome	60.83	32.57	15	302897	14760	42303663
Lip dry	60.41	32.57	67	302845	1616	42316807
Keratoconus	60.31	32.57	27	302885	129	42318294
Photophobia	59.88	32.57	159	302753	7960	42310463
Colitis ulcerative	59.30	32.57	59	302853	26116	42292307
Mania	59.24	32.57	4	302908	10543	42307880
General physical condition abnormal	59.11	32.57	108	302804	4181	42314242
Bronchiectasis	59.05	32.57	27	302885	17992	42300431
Supraventricular tachycardia	58.66	32.57	9	302903	12399	42306024
Knee operation	58.48	32.57	82	302830	2526	42315897
Squamous cell carcinoma of skin	58.43	32.57	10	302902	12716	42305707
Acarodermatitis	58.31	32.57	46	302866	707	42317716
Coronary artery stenosis	58.11	32.57	4	302908	10375	42308048
Metastases to central nervous system	57.95	32.57	4	302908	10351	42308072
Injection site exfoliation	57.72	32.57	20	302892	39	42318384
Gynaecomastia	57.43	32.57	10	302902	12557	42305866
Ill-defined disorder	57.29	32.57	22	302890	16274	42302149
Pneumonia bacterial	57.17	32.57	20	302892	15672	42302751
Hypertensive crisis	56.95	32.57	4	302908	10202	42308221
Generalised oedema	56.82	32.57	19	302893	15317	42303106
Fear	56.55	32.57	6	302906	10959	42307464
Faeces discoloured	56.53	32.57	25	302887	16989	42301434
Hepatitis C	56.46	32.57	4	302908	10129	42308294
Schizophrenia	56.45	32.57	5	302907	10545	42307878
Gastric haemorrhage	56.22	32.57	5	302907	10510	42307913
Face oedema	56.02	32.57	14	302898	13652	42304771
Decubitus ulcer	55.96	32.57	5	302907	10472	42307951
Large intestine perforation	55.43	32.57	3	302909	9533	42308890
Rebound nasal congestion	55.35	32.57	14	302898	0	42318423
Enterobiasis	55.35	32.57	14	302898	0	42318423
Hypotonia	55.18	32.57	3	302909	9496	42308927
Failure to thrive	54.65	32.57	3	302909	9419	42309004
Needle issue	54.62	32.57	161	302751	8566	42309857
Breath sounds abnormal	54.44	32.57	10	302902	12083	42306340
Electrocardiogram abnormal	53.77	32.57	5	302907	10140	42308283
Transfusion	53.60	32.57	6	302906	10508	42307915
Intestinal perforation	53.48	32.57	7	302905	10867	42307556
Urine output decreased	53.47	32.57	7	302905	10866	42307557
Injection site induration	53.46	32.57	92	302820	3395	42315028
Blood test abnormal	53.33	32.57	13	302899	12893	42305530
Injury	53.25	32.57	48	302864	22268	42296155
Bronchospasm	53.21	32.57	13	302899	12872	42305551
Skin depigmentation	53.07	32.57	36	302876	432	42317991
Skin hypopigmentation	52.83	32.57	34	302878	371	42318052
Staphylococcal bacteraemia	52.72	32.57	8	302904	11113	42307310
Heart rate irregular	52.67	32.57	24	302888	16026	42302397
Lung infiltration	52.41	32.57	17	302895	13972	42304451
Iron deficiency	52.34	32.57	8	302904	11053	42307370
Bladder cancer	52.15	32.57	28	302884	17019	42301404
Candida infection	52.15	32.57	46	302866	21564	42296859
Dyspnoea exertional	52.14	32.57	182	302730	49966	42268457
Klebsiella infection	51.82	32.57	9	302903	11323	42307100
Molluscum contagiosum	51.65	32.57	32	302880	325	42318098
Nasal pruritus	51.61	32.57	26	302886	169	42318254
Eye operation	51.18	32.57	38	302874	531	42317892
Blood sodium decreased	51.08	32.57	33	302879	18129	42300294
Hyperhidrosis	50.98	32.57	405	302507	90107	42228316
Large intestine polyp	50.65	32.57	4	302908	9261	42309162
Eyelid thickening	50.40	32.57	14	302898	6	42318417
Renal disorder	50.34	32.57	80	302832	28900	42289523
Neurological symptom	50.19	32.57	6	302906	9985	42308438
Aortic stenosis	50.06	32.57	3	302909	8742	42309681
Product administered to patient of inappropriate age	50.03	32.57	107	302805	4654	42313769
Nephrotic syndrome	49.88	32.57	3	302909	8715	42309708
Emotional distress	49.87	32.57	26	302886	16067	42302356
Pneumonia fungal	49.86	32.57	4	302908	9142	42309281
Oral candidiasis	49.73	32.57	20	302892	14385	42304038
Sinus headache	49.72	32.57	52	302860	1171	42317252
Kidney transplant rejection	49.65	32.57	3	302909	8680	42309743
Micturition urgency	49.14	32.57	12	302900	11886	42306537
Hiccups	48.87	32.57	13	302899	12158	42306265
Cardiovascular disorder	48.75	32.57	17	302895	13348	42305075
Mobility decreased	48.61	32.57	112	302800	35194	42283229
Enteritis	48.57	32.57	9	302903	10807	42307616
Left ventricular hypertrophy	48.32	32.57	5	302907	9314	42309109
Renal cyst	48.10	32.57	7	302905	10032	42308391
Product administration error	48.05	32.57	36	302876	18307	42300116
Escherichia infection	48.04	32.57	11	302901	11385	42307038
Respiratory rate increased	48.01	32.57	10	302902	11052	42307371
Mental impairment	47.88	32.57	14	302898	12303	42306120
Platelet count increased	47.87	32.57	9	302903	10694	42307729
Gastric disorder	47.37	32.57	13	302899	11909	42306514
Red blood cell sedimentation rate increased	47.37	32.57	7	302905	9917	42308506
Swelling face	46.81	32.57	346	302566	27208	42291215
Dark circles under eyes	46.70	32.57	19	302893	68	42318355
Chromaturia	46.43	32.57	28	302884	15961	42302462
Erectile dysfunction	45.95	32.57	66	302846	24847	42293576
Skin mass	45.82	32.57	104	302808	4712	42313711
Post procedural haemorrhage	45.78	32.57	6	302906	9306	42309117
Back pain	45.77	32.57	720	302192	141056	42177367
Swollen tongue	45.68	32.57	50	302862	21181	42297242
Polyuria	45.67	32.57	8	302904	10003	42308420
Shoulder operation	45.42	32.57	54	302858	1407	42317016
Lip erythema	45.28	32.57	20	302892	92	42318331
Incorrect dose administered by product	45.27	32.57	17	302895	46	42318377
Blood calcium increased	45.25	32.57	4	302908	8450	42309973
Off label use	44.44	32.57	3921	298991	634414	41684009
Adverse drug reaction	44.43	32.57	128	302784	37306	42281117
Sinonasal obstruction	44.26	32.57	23	302889	161	42318262
Anal incontinence	43.90	32.57	7	302905	9374	42309049
Device dislocation	43.90	32.57	3	302909	7828	42310595
Vitiligo	43.78	32.57	49	302863	1194	42317229
Device operational issue	43.77	32.57	26	302886	243	42318180
Intentional product misuse	43.74	32.57	650	302262	61250	42257173
Apnoea	43.71	32.57	3	302909	7800	42310623
Coronary artery occlusion	43.68	32.57	12	302900	10985	42307438
Psoriasis	43.67	32.57	533	302379	48071	42270352
Sleep disorder due to general medical condition, insomnia type	43.55	32.57	53	302859	1416	42317007
Injection site eczema	43.49	32.57	11	302901	0	42318423
Exfoliative rash	43.49	32.57	68	302844	2314	42316109
Mood altered	43.47	32.57	171	302741	10547	42307876
Pollakiuria	43.13	32.57	58	302854	22447	42295976
Allergy to chemicals	43.02	32.57	20	302892	106	42318317
Bundle branch block right	42.95	32.57	4	302908	8102	42310321
Post procedural complication	42.62	32.57	18	302894	12572	42305851
Coordination abnormal	42.58	32.57	4	302908	8046	42310377
Blood lactic acid increased	42.50	32.57	4	302908	8035	42310388
Eczema asteatotic	42.43	32.57	31	302881	422	42318001
Lung neoplasm malignant	42.42	32.57	44	302868	19103	42299320
Embolism	42.25	32.57	6	302906	8757	42309666
Pain	42.21	32.57	2136	300776	242712	42075711
Diffuse large B-cell lymphoma	42.17	32.57	8	302904	9446	42308977
Injection site hypersensitivity	41.96	32.57	30	302882	394	42318029
Asphyxia	41.82	32.57	5	302907	8321	42310102
Spinal osteoarthritis	41.75	32.57	6	302906	8680	42309743
Cardiac disorder	41.75	32.57	192	302720	48740	42269683
Central nervous system lesion	41.39	32.57	4	302908	7866	42310557
Skin erosion	41.37	32.57	74	302838	2817	42315606
Abscess	41.30	32.57	25	302887	14223	42304200
Facial paralysis	40.89	32.57	19	302893	12544	42305879
Nasal inflammation	40.78	32.57	30	302882	413	42318010
Eye ulcer	40.64	32.57	15	302897	38	42318385
Eyelid infection	40.37	32.57	15	302897	39	42318384
Skin warm	40.07	32.57	72	302840	2751	42315672
Mydriasis	40.03	32.57	7	302905	8763	42309660
Skin wound	39.96	32.57	36	302876	670	42317753
Apathy	39.96	32.57	6	302906	8400	42310023
Anhedonia	39.87	32.57	4	302908	7636	42310787
Neuralgia	39.81	32.57	76	302836	25571	42292852
Paranasal sinus hypersecretion	38.96	32.57	45	302867	1136	42317287
Lack of administration site rotation	38.87	32.57	17	302895	76	42318347
Spinal compression fracture	38.84	32.57	4	302908	7479	42310944
Infective pulmonary exacerbation of cystic fibrosis	38.53	32.57	5	302907	7813	42310610
Diverticulitis	38.49	32.57	64	302848	22709	42295714
Endocarditis	38.34	32.57	6	302906	8146	42310277
Tinea infection	38.19	32.57	27	302885	348	42318075
Maternal exposure during pregnancy	38.18	32.57	3	302909	6975	42311448
Cerebral ischaemia	38.05	32.57	3	302909	6956	42311467
Dermatitis bullous	38.05	32.57	7	302905	8449	42309974
Immune thrombocytopenia	38.03	32.57	16	302896	11200	42307223
Blood magnesium decreased	37.93	32.57	5	302907	7721	42310702
Vitamin D deficiency	37.83	32.57	6	302906	8067	42310356
Squamous cell carcinoma	37.32	32.57	23	302889	12959	42305464
Madarosis	37.24	32.57	30	302882	476	42317947
Adenovirus infection	37.05	32.57	3	302909	6806	42311617
Atopic keratoconjunctivitis	36.94	32.57	10	302902	3	42318420
Acute generalised exanthematous pustulosis	36.83	32.57	8	302904	8587	42309836
Oesophageal discomfort	36.73	32.57	17	302895	89	42318334
Drug ineffective for unapproved indication	36.72	32.57	495	302417	45668	42272755
Hypopnoea	36.62	32.57	6	302906	7876	42310547
Vitreous floaters	36.59	32.57	88	302824	4142	42314281
Tinnitus	36.54	32.57	96	302816	28842	42289581
Encephalitis	36.36	32.57	10	302902	9148	42309275
Proctalgia	36.28	32.57	4	302908	7089	42311334
Motor dysfunction	36.11	32.57	7	302905	8139	42310284
Croup infectious	35.77	32.57	30	302882	505	42317918
Eczema herpeticum	35.66	32.57	24	302888	284	42318139
Circumoral swelling	35.58	32.57	9	302903	0	42318423
Sweating fever	35.58	32.57	9	302903	0	42318423
Abdominal pain lower	35.35	32.57	21	302891	12071	42306352
Gastroenteritis viral	35.04	32.57	133	302779	8066	42310357
Salivary hypersecretion	34.93	32.57	17	302895	10926	42307497
Potentiating drug interaction	34.78	32.57	3	302909	6465	42311958
Increased viscosity of upper respiratory secretion	34.73	32.57	25	302887	332	42318091
Peripheral arterial occlusive disease	34.61	32.57	4	302908	6834	42311589
Hemiplegia	34.45	32.57	7	302905	7872	42310551
Nephrolithiasis	34.17	32.57	140	302772	36690	42281733
Nocturia	34.07	32.57	22	302890	12090	42306333
Steroid dependence	33.86	32.57	4	302908	6718	42311705
Oesophagitis	33.82	32.57	35	302877	15212	42303211
Incorrect dose administered by device	33.77	32.57	66	302846	2690	42315733
Ecchymosis	33.66	32.57	7	302905	7745	42310678
Vasculitis	33.66	32.57	49	302863	18345	42300078
Impaired healing	33.65	32.57	43	302869	17010	42301413
Hypereosinophilic syndrome	33.48	32.57	27	302885	429	42317994
Discharge	33.45	32.57	30	302882	555	42317868
Pulmonary vasculitis	33.44	32.57	3	302909	6263	42312160
Diarrhoea haemorrhagic	33.38	32.57	7	302905	7700	42310723
Gout	33.24	32.57	96	302816	27959	42290464
Neuritis	33.14	32.57	3	302909	6217	42312206
Brain injury	33.05	32.57	7	302905	7648	42310775
Muscle spasms	33.04	32.57	422	302490	85622	42232801
Dermatitis contact	33.02	32.57	88	302824	4415	42314008
Lip pruritus	32.91	32.57	12	302900	29	42318394
Alopecia areata	32.89	32.57	24	302888	326	42318097

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pruritus	49903.91	22.76	34566	609157	546994	109398582
Injection site pain	39527.29	22.76	19663	624060	158259	109787317
Dry skin	36599.42	22.76	15984	627739	91669	109853907
Product use in unapproved indication	32169.09	22.76	23956	619767	423421	109522155
Eczema	28674.27	22.76	11983	631740	60310	109885266
Exposure via skin contact	20056.78	22.76	5950	637773	7197	109938379
Product dose omission in error	16964.56	22.76	6031	637692	17481	109928095
Inappropriate schedule of product administration	16650.95	22.76	11826	631897	191811	109753765
Skin exfoliation	16375.91	22.76	8643	635080	79008	109866568
Dry eye	15292.46	22.76	7142	636581	48651	109896925
Accidental exposure to product	14932.30	22.76	6794	636929	43214	109902362
Therapeutic response shortened	13846.30	22.76	5529	638194	24054	109921522
Injection site swelling	13695.70	22.76	6839	636884	54951	109890625
Incorrect dose administered	13347.90	22.76	8009	635714	95632	109849944
Product dose omission issue	13338.17	22.76	12578	631145	309204	109636372
Rash	12942.94	22.76	19550	624173	801414	109144162
Eye pruritus	11943.37	22.76	5123	638600	27652	109917924
Skin fissures	10777.12	22.76	4378	639345	20080	109925496
Skin burning sensation	10082.27	22.76	4042	639681	17783	109927793
Injection site erythema	9371.03	22.76	6183	637540	87993	109857583
Ocular hyperaemia	7899.58	22.76	4074	639649	35212	109910364
Sleep disorder due to a general medical condition	7764.82	22.76	4430	639293	47682	109897894
Rash erythematous	7544.00	22.76	5125	638598	76707	109868869
Eye irritation	6652.97	22.76	3444	640279	30008	109915568
Therapeutic response decreased	6600.42	22.76	5042	638681	91457	109854119
Rebound eczema	6009.71	22.76	1519	642204	333	109945243
Erythema	5656.99	22.76	7690	636033	283757	109661819
Rebound atopic dermatitis	5568.39	22.76	1458	642265	583	109944993
Injection site pruritus	5463.56	22.76	3516	640207	47742	109897834
Condition aggravated	5377.13	22.76	12630	631093	722206	109223370
Product preparation error	5347.57	22.76	2108	641615	8771	109936805
Injection site urticaria	4901.36	22.76	2265	641458	14950	109930626
Skin haemorrhage	4890.00	22.76	2540	641183	22287	109923289
Injection site rash	4736.37	22.76	2439	641284	20980	109924596
Impaired quality of life	4494.30	22.76	2561	641162	27456	109918120
Injection site bruising	4491.32	22.76	3113	640610	48150	109897426
Rash macular	4224.54	22.76	2695	641028	35991	109909585
Conjunctivitis	4192.26	22.76	2553	641170	31239	109914337
Skin swelling	3986.39	22.76	1570	642153	6510	109939066
Rebound effect	3945.35	22.76	1861	641862	12945	109932631
Skin weeping	3870	22.76	1258	642465	2477	109943099
Acute kidney injury	3474.61	22.76	43	643680	635387	109310189
Intentional dose omission	2951.35	22.76	1693	642030	18387	109927189
Vision blurred	2856.24	22.76	3636	640087	125386	109820190
Arthralgia	2846.98	22.76	10468	633255	769164	109176412
Toxicity to various agents	2748.44	22.76	8	643715	480547	109465029
Scratch	2723.31	22.76	1386	642337	11593	109933983
Nasal congestion	2698.74	22.76	3090	640633	95192	109850384
Illness	2639.31	22.76	2805	640918	79366	109866210
Skin irritation	2576.66	22.76	1442	642281	14877	109930699
Drug interaction	2553.79	22.76	79	643644	500104	109445472
Anaemia	2550.10	22.76	161	643562	546925	109398651
Dermatitis atopic	2409.21	22.76	1624	642099	23917	109921659
Product prescribing issue	2384.28	22.76	1261	642462	11511	109934065
Lacrimation increased	2378.98	22.76	1736	641987	29214	109916362
Cough	2280.54	22.76	6871	636852	454770	109490806
Oral herpes	2229.71	22.76	1777	641946	34303	109911273
Death	2109.96	22.76	720	643003	698149	109247427
Hypotension	2106.62	22.76	280	643443	523569	109422007
Infusion related reaction	2094.35	22.76	23	643700	381139	109564437
Confusional state	2042.25	22.76	188	643535	468492	109477084
Neutropenia	1980.24	22.76	41	643682	374579	109570997
Drug intolerance	1963.40	22.76	97	643626	406415	109539161
Rash pruritic	1893.29	22.76	2585	641138	95484	109850092
Injection site mass	1890.32	22.76	1380	642343	23233	109922343
Thrombocytopenia	1860.85	22.76	34	643689	348851	109596725
Eye discharge	1828.30	22.76	932	642791	7822	109937754
Injection site reaction	1826.58	22.76	2418	641305	86652	109858924
Diarrhoea	1816.37	22.76	2391	641332	1137114	108808462
Nausea	1813.21	22.76	2751	640972	1232939	108712637
Febrile neutropenia	1806.11	22.76	6	643717	316761	109628815
COVID-19	1777.77	22.76	4209	639514	240851	109704725
Vomiting	1775.83	22.76	1616	642107	909059	109036517
Product storage error	1757.09	22.76	1257	642466	20471	109925105
Rhinorrhoea	1649.62	22.76	2480	641243	100186	109845390
General physical health deterioration	1593.46	22.76	278	643445	425017	109520559
Extra dose administered	1583.28	22.76	948	642775	11211	109934365
Synovitis	1517.09	22.76	14	643709	274078	109671498
Drug ineffective	1494.80	22.76	14422	629301	1506118	108439458
Eyelids pruritus	1440.30	22.76	499	643224	1298	109944278
Hepatic enzyme increased	1434.68	22.76	115	643608	320777	109624799
Hypertension	1426.92	22.76	592	643131	509492	109436084
Injection site irritation	1417.25	22.76	653	643070	4271	109941305
Sleep disorder	1375.74	22.76	3352	640371	195292	109750284
Eye swelling	1367.70	22.76	1295	642428	31753	109913823
Asthenia	1355.52	22.76	1211	642512	687788	109257788
Eye pain	1333.90	22.76	1551	642172	48548	109897028
Completed suicide	1333.80	22.76	14	643709	242367	109703209
Anosmia	1302.03	22.76	845	642878	11627	109933949
Eyelid margin crusting	1272.59	22.76	469	643254	1547	109944029
Hand deformity	1235.00	22.76	6	643717	218500	109727076
Abdominal pain	1231.68	22.76	730	642993	512259	109433317
Erythema of eyelid	1230.39	22.76	552	643171	3363	109942213
Overdose	1225.52	22.76	28	643695	233766	109711810
Drug effect less than expected	1213.40	22.76	668	643055	6652	109938924
Pemphigus	1206.89	22.76	7	643716	214563	109731013
Oedema peripheral	1191.71	22.76	233	643490	328427	109617149
Disease progression	1184.86	22.76	56	643667	243978	109701598
Eyelid skin dryness	1181.76	22.76	344	643379	365	109945211
Treatment failure	1175.85	22.76	123	643600	277111	109668465
Contraindicated product administered	1173.83	22.76	67	643656	248200	109697376
Sepsis	1172.43	22.76	239	643484	327107	109618469
Hyponatraemia	1169.34	22.76	19	643704	217634	109727942
Pancytopenia	1163.22	22.76	10	643713	209603	109735973
Skin discolouration	1152.50	22.76	1425	642298	47621	109897955
Haemoglobin decreased	1152.24	22.76	75	643648	248652	109696924
Lack of injection site rotation	1124.33	22.76	372	643351	794	109944782
Intentional product use issue	1101.95	22.76	91	643632	247815	109697761
Pericarditis	1087.85	22.76	43	643680	219071	109726505
Systemic lupus erythematosus	1075.63	22.76	114	643609	254224	109691352
Glossodynia	1055.42	22.76	58	643665	221946	109723630
Platelet count decreased	1054.22	22.76	74	643649	230369	109715207
Periorbital swelling	1051.49	22.76	552	643171	4953	109940623
White blood cell count decreased	1039.79	22.76	77	643646	229313	109716263
Swelling of eyelid	1034.15	22.76	582	643141	6071	109939505
C-reactive protein increased	1020.46	22.76	62	643661	217857	109727719
Skin discomfort	1019.69	22.76	404	643319	1706	109943870
Injection site vesicles	1018.78	22.76	505	643218	3966	109941610
Injection site discomfort	1013.82	22.76	582	643141	6325	109939251
Drug abuse	1012.98	22.76	3	643720	177408	109768168
Rheumatoid arthritis	1002.37	22.76	254	643469	299359	109646217
Pneumonia	986.80	22.76	2287	641436	874427	109071149
Arthropathy	984.80	22.76	232	643491	287290	109658286
Renal failure	983.05	22.76	92	643631	226482	109719094
Fear of injection	982.76	22.76	625	643098	8286	109937290
Malignant neoplasm progression	980.13	22.76	6	643717	174561	109771015
Decreased appetite	978.06	22.76	801	642922	475045	109470531
Dermatitis	971.62	22.76	994	642729	26843	109918733
Respiratory failure	954.36	22.76	80	643643	215252	109730324
Cardiac arrest	952.33	22.76	46	643677	196707	109748869
Hypokalaemia	947.88	22.76	24	643699	182424	109763152
Blood creatinine increased	939.19	22.76	27	643696	182862	109762714
Alanine aminotransferase increased	936.93	22.76	29	643694	183744	109761832
Lower respiratory tract infection	929.68	22.76	150	643573	242956	109702620
Product use issue	926.96	22.76	3932	639791	307763	109637813
Helicobacter infection	895.05	22.76	38	643685	181839	109763737
Blepharitis	882.44	22.76	461	643262	4091	109941485
Impaired healing	858.40	22.76	78	643645	196639	109748937
Eye disorder	857.96	22.76	947	642776	27959	109917617
Type 2 diabetes mellitus	855.95	22.76	42	643681	177190	109768386
Pulmonary embolism	839.04	22.76	124	643599	214350	109731226
Fall	838.55	22.76	1389	642334	602093	109343483
Pain of skin	838.53	22.76	790	642933	19239	109926337
Tachycardia	833.40	22.76	155	643568	226490	109719086
Liver injury	825.92	22.76	9	643714	150404	109795172
Stomatitis	818.01	22.76	276	643447	269966	109675610
Multiple organ dysfunction syndrome	815.83	22.76	13	643710	151697	109793879
Oedema	808.61	22.76	127	643596	209849	109735727
Psoriatic arthropathy	799.90	22.76	101	643622	196660	109748916
Aspartate aminotransferase increased	798.54	22.76	30	643693	159906	109785670
Leukopenia	794.91	22.76	14	643709	148777	109796799
Septic shock	784.96	22.76	30	643693	157498	109788078
Dehydration	783.08	22.76	323	643400	279188	109666388
Renal impairment	777.68	22.76	92	643631	188353	109757223
Musculoskeletal pain	771.27	22.76	83	643640	182940	109762636
Folliculitis	769.15	22.76	53	643670	167600	109777976
Gastrointestinal haemorrhage	769.15	22.76	49	643674	165469	109780107
Constipation	768.07	22.76	576	643147	357210	109588366
Bradycardia	763.55	22.76	33	643690	155484	109790092
Muscle injury	757.44	22.76	12	643711	140795	109804781
Intentional overdose	752.08	22.76	3	643720	132498	109813078
Wound	751.48	22.76	216	643507	234221	109711355
Pleural effusion	750.36	22.76	80	643643	177629	109767947
Rheumatoid factor positive	747.08	22.76	3	643720	131637	109813939
Injection site discolouration	736.76	22.76	527	643196	8576	109937000
Injection site haemorrhage	735.03	22.76	934	642789	32094	109913482
Blood cholesterol increased	734.06	22.76	102	643621	184683	109760893
Hordeolum	730.12	22.76	417	643306	4484	109941092
Oropharyngeal pain	729.15	22.76	2080	641643	133196	109812380
Injury	727.89	22.76	88	643635	177177	109768399
Hyperkalaemia	720.45	22.76	14	643709	135782	109809794
Delirium	720.10	22.76	13	643710	135012	109810564
Irritable bowel syndrome	711.40	22.76	67	643656	164148	109781428
C-reactive protein abnormal	710.99	22.76	8	643715	129687	109815889
Osteoarthritis	704.20	22.76	110	643613	182513	109763063
Joint swelling	702.75	22.76	929	642794	441916	109503660
Malaise	701.95	22.76	1820	641903	669999	109275577
Cardiac failure	692.60	22.76	127	643596	187499	109758077
Mobility decreased	680.31	22.76	265	643458	237157	109708419
Ill-defined disorder	676.82	22.76	65	643658	156788	109788788
Interstitial lung disease	676.07	22.76	32	643691	139302	109806274
Fibromyalgia	674.99	22.76	96	643627	170813	109774763
Device use issue	670.71	22.76	361	643362	3423	109942153
Eyelid irritation	665.86	22.76	250	643473	881	109944695
Injection site warmth	665.33	22.76	653	643070	16752	109928824
Eyelid rash	662.93	22.76	201	643522	275	109945301
Eye inflammation	658.71	22.76	494	643229	8677	109936899
Therapeutic response unexpected	647.69	22.76	746	642977	23097	109922479
Therapy non-responder	638.76	22.76	81	643642	157226	109788350
Intercepted product storage error	638.32	22.76	219	643504	547	109945029
Cardio-respiratory arrest	635.64	22.76	7	643716	115829	109829747
Drug-induced liver injury	634.46	22.76	13	643710	120054	109825522
Neutrophil count decreased	616.71	22.76	19	643704	120922	109824654
Liver disorder	616.24	22.76	58	643665	142185	109803391
Acne	612.62	22.76	861	642862	32659	109912917
Electrocardiogram QT prolonged	610.28	22.76	4	643719	108956	109836620
Scab	604.33	22.76	548	643175	12688	109932888
Joint range of motion decreased	604.27	22.76	24	643699	121808	109823768
Rhabdomyolysis	603.05	22.76	22	643701	120379	109825197
Seizure	602.83	22.76	266	643457	220919	109724657
Neurodermatitis	600.17	22.76	308	643415	2624	109942952
Weight decreased	598.47	22.76	1134	642589	466923	109478653
Depressed level of consciousness	589.94	22.76	13	643710	112265	109833311
Coma	588.76	22.76	22	643701	117847	109827729
Deep vein thrombosis	587.92	22.76	64	643659	139823	109805753
Atrial fibrillation	587.80	22.76	301	643422	229341	109716235
Blood pressure increased	581.81	22.76	395	643328	257978	109687598
Muscular weakness	581.03	22.76	364	643359	248104	109697472
Pyrexia	577.73	22.76	2979	640744	895286	109050290
Hypoglycaemia	575.40	22.76	23	643700	116081	109829495
Fatigue	573.83	22.76	4438	639285	1211520	108734056
Bursitis	573.53	22.76	49	643674	129869	109815707
Sensitive skin	572.28	22.76	323	643400	3389	109942187
Product administered at inappropriate site	569.33	22.76	368	643355	5025	109940551
Surgery	562.47	22.76	925	642798	40358	109905218
Medication error	562.44	22.76	10	643713	105356	109840220
Obesity	556.58	22.76	24	643699	113327	109832249
Somnolence	555.22	22.76	547	643176	296902	109648674
Rectal haemorrhage	552.21	22.76	37	643686	119796	109825780
Injection site dryness	551.46	22.76	189	643534	470	109945106
Eczema eyelids	546.59	22.76	169	643554	258	109945318
Influenza	544.42	22.76	2187	641536	166914	109778662
Sneezing	536.84	22.76	789	642934	31195	109914381
Nasopharyngitis	534.29	22.76	4027	639696	390334	109555242
Suicide attempt	520.93	22.76	18	643705	103376	109842200
Ocular discomfort	517.90	22.76	416	643307	8117	109937459
Mucosal inflammation	517.88	22.76	8	643715	96133	109849443
Hypoxia	508.48	22.76	74	643649	129441	109816135
Secretion discharge	501.12	22.76	604	643119	19640	109925936
Hypercholesterolaemia	496.09	22.76	6	643717	90831	109854745
Prescribed overdose	491.59	22.76	3	643720	87578	109857998
Eye infection	489.61	22.76	509	643214	14009	109931567
Nasal obstruction	485.58	22.76	280	643443	3070	109942506
Discomfort	481.53	22.76	2496	641227	212211	109733365
Syncope	480.02	22.76	292	643431	202244	109743332
International normalised ratio increased	477.20	22.76	5	643718	86767	109858809
Ascites	475.30	22.76	14	643709	92794	109852782
Hepatitis	474.80	22.76	10	643713	90044	109855532
Drug hypersensitivity	474.60	22.76	1229	642494	452861	109492715
Stress	468.19	22.76	1514	642209	103834	109841742
Musculoskeletal stiffness	467.54	22.76	564	643159	279258	109666318
Gastrointestinal disorder	465.40	22.76	433	643290	241519	109704057
Lactic acidosis	464.65	22.76	17	643706	92794	109852782
Pulmonary fibrosis	462.96	22.76	34	643689	102008	109843568
Adverse event	461.79	22.76	48	643675	108761	109836815
Unintentional use for unapproved indication	450.66	22.76	143	643580	250	109945326
Epilepsy	447.27	22.76	36	643687	100173	109845403
Abdominal discomfort	445.34	22.76	1023	642700	392835	109552741
Depression	445.10	22.76	725	642998	316610	109628966
Encephalopathy	439.79	22.76	6	643717	81049	109864527
Hepatic function abnormal	438.10	22.76	19	643704	89276	109856300
Peripheral venous disease	437.06	22.76	11	643712	84106	109861470
Off label use of device	436.12	22.76	148	643575	353	109945223
Swollen joint count increased	434.46	22.76	11	643712	83650	109861926
Wound infection	432.38	22.76	34	643689	96431	109849145
Cardiac failure congestive	431.69	22.76	169	643554	150831	109794745
Eyelid exfoliation	429.26	22.76	131	643592	186	109945390
Agitation	420.43	22.76	75	643648	112976	109832600
Periorbital irritation	418.02	22.76	107	643616	30	109945546
Lung disorder	415.03	22.76	268	643455	179779	109765797
Liver function test increased	414.96	22.76	25	643698	88523	109857053
Drug reaction with eosinophilia and systemic symptoms	414.61	22.76	14	643709	82081	109863495
Blood bilirubin increased	406.35	22.76	7	643716	75965	109869611
Tremor	404.38	22.76	349	643374	201883	109743693
Initial insomnia	403.10	22.76	393	643330	9996	109935580
Blood pressure systolic increased	399.56	22.76	20	643703	82971	109862605
Visual impairment	392.13	22.76	1687	642036	132741	109812835
Sedation	388.02	22.76	3	643720	69680	109875896
Hallucination	386.66	22.76	63	643660	101369	109844207
Haematochezia	385.96	22.76	98	643625	115426	109830150
Acute myocardial infarction	385.60	22.76	26	643697	83751	109861825
Neuropathy peripheral	383.92	22.76	289	643434	178988	109766588
Cognitive disorder	380.84	22.76	35	643688	87476	109858100
Product quality issue	377.40	22.76	17	643706	77282	109868294
Haematuria	375.57	22.76	28	643695	82977	109862599
Night sweats	374.76	22.76	155	643568	133828	109811748
Pneumonia aspiration	374.50	22.76	25	643698	81208	109864368
Injection site inflammation	371.91	22.76	270	643453	4501	109941075
Myocardial infarction	371.43	22.76	342	643381	191741	109753835
Blood creatine phosphokinase increased	370.69	22.76	12	643711	73065	109872511
Hyperglycaemia	370.38	22.76	34	643689	85056	109860520
Live birth	369.18	22.76	7	643716	69477	109876099
Hospitalisation	368.91	22.76	1726	641997	140767	109804809
Urticaria	368.28	22.76	3140	640583	315717	109629859
Red blood cell sedimentation rate increased	367.25	22.76	22	643701	78280	109867296
Suicidal ideation	365.66	22.76	55	643668	93882	109851694
Oesophageal food impaction	361.92	22.76	133	643590	434	109945142
Hand dermatitis	360.13	22.76	143	643580	608	109944968
Eye allergy	357.47	22.76	157	643566	902	109944674
Melaena	353.45	22.76	10	643713	68747	109876829
Hepatic failure	353.35	22.76	10	643713	68729	109876847
Haematocrit decreased	349.92	22.76	7	643716	66110	109879466
Liver function test abnormal	347.35	22.76	12	643711	68938	109876638
Injection site exfoliation	347.19	22.76	120	643603	309	109945267
Coronary artery disease	346.01	22.76	17	643706	71673	109873903
Blood pressure fluctuation	345.03	22.76	23	643700	74801	109870775
Food allergy	344.79	22.76	499	643224	19449	109926127
Hypomagnesaemia	334.21	22.76	3	643720	60367	109885209
Transaminases increased	330.43	22.76	8	643715	63382	109882194
Loss of consciousness	329.58	22.76	394	643329	195912	109749664
Cholestasis	329.40	22.76	10	643713	64508	109881068
Serotonin syndrome	327.18	22.76	3	643720	59150	109886426
Chest pain	327.02	22.76	1110	642613	375265	109570311
Hepatotoxicity	326.72	22.76	9	643714	63391	109882185
Respiratory tract congestion	324.18	22.76	617	643106	30240	109915336
Blood pressure decreased	322.11	22.76	133	643590	114958	109830618
Grip strength decreased	321.29	22.76	43	643680	80131	109865445
Acute respiratory failure	317.30	22.76	34	643689	75226	109870350
Wrong technique in device usage process	315.60	22.76	286	643437	6615	109938961
Symptom recurrence	314.02	22.76	244	643479	4528	109941048
Chronic kidney disease	312.79	22.76	38	643685	76253	109869323
Blood alkaline phosphatase increased	312.38	22.76	27	643696	70908	109874668
Dyspnoea	311.63	22.76	8536	635187	1098336	108847240
Dysarthria	310.21	22.76	57	643666	84064	109861512
Amnesia	307.89	22.76	114	643609	105294	109840282
Jaundice	303.08	22.76	9	643714	59227	109886349
Orthostatic hypotension	300.72	22.76	22	643701	66227	109879349
Toxic epidermal necrolysis	300.23	22.76	6	643717	56721	109888855
Gamma-glutamyltransferase increased	297.63	22.76	14	643709	61295	109884281
Sleep disorder due to general medical condition, insomnia type	297.41	22.76	121	643602	105522	109840054
Cardiogenic shock	295.99	22.76	8	643715	57330	109888246
Hyposmia	295.30	22.76	141	643582	1010	109944566
Hepatic cirrhosis	294.40	22.76	27	643696	67599	109877977
Respiratory arrest	294.19	22.76	10	643713	58289	109887287
Unresponsive to stimuli	292.98	22.76	20	643703	63770	109881806
Plasma cell myeloma	291.21	22.76	19	643704	62917	109882659
Upper-airway cough syndrome	290.75	22.76	408	643315	15449	109930127
Therapeutic product effect decreased	290.41	22.76	617	643106	243699	109701877
Altered state of consciousness	290.39	22.76	10	643713	57616	109887960
Perioral dermatitis	289.94	22.76	121	643602	600	109944976
Dyspepsia	287.09	22.76	416	643307	190549	109755027
Rash maculo-papular	285.37	22.76	45	643678	74177	109871399
Hypothyroidism	285.31	22.76	42	643681	72857	109872719
Oxygen saturation decreased	284.41	22.76	296	643427	156686	109788890
Cytomegalovirus infection	283.30	22.76	7	643716	54437	109891139
Underdose	283.14	22.76	23	643700	63531	109882045
Lymphocyte count decreased	281.40	22.76	12	643711	57231	109888345
Red blood cell count decreased	279.93	22.76	29	643694	65894	109879682
Drug resistance	276.52	22.76	12	643711	56362	109889214
Pharyngitis streptococcal	275.88	22.76	363	643360	12914	109932662
Tubulointerstitial nephritis	275.03	22.76	9	643714	54275	109891301
Pulmonary oedema	272.65	22.76	122	643601	100537	109845039
Colitis	272.51	22.76	127	643596	102196	109843380
Hepatic cytolysis	272.44	22.76	11	643712	55042	109890534
Blood urea increased	271.90	22.76	11	643712	54946	109890630
Disorientation	269.12	22.76	44	643679	70627	109874949
Acute respiratory distress syndrome	268.88	22.76	9	643714	53189	109892387
Upper gastrointestinal haemorrhage	266.34	22.76	5	643718	50091	109895485
Urinary retention	266.22	22.76	43	643680	69640	109875936
Angioedema	265.83	22.76	120	643603	98380	109847196
Myalgia	264.04	22.76	2204	641519	220177	109725399
Dizziness	263.88	22.76	2694	641029	695499	109250077
Generalised tonic-clonic seizure	263.78	22.76	13	643710	54667	109890909
SARS-CoV-2 test positive	263.12	22.76	403	643320	16532	109929044
Pancreatitis	261.89	22.76	108	643615	93425	109852151
Haematemesis	261.64	22.76	22	643701	59086	109886490
Skin disorder	261.03	22.76	690	643033	42223	109903353
Blood glucose increased	260.77	22.76	232	643491	132264	109813312
Foreign body sensation in eyes	260.62	22.76	189	643534	3145	109942431
Sinus operation	260.23	22.76	181	643542	2810	109942766
Heart rate decreased	260.01	22.76	79	643644	82677	109862899
Shock	257.69	22.76	13	643710	53575	109892001
Full blood count abnormal	256.19	22.76	18	643705	56034	109889542
Hypercalcaemia	250.77	22.76	4	643719	46653	109898923
Device defective	248.40	22.76	194	643529	3628	109941948
Urinary tract infection	247.63	22.76	1017	642706	325265	109620311
Ventricular tachycardia	247.45	22.76	10	643713	49999	109895577
Productive cough	247.24	22.76	1316	642407	112989	109832587
Burning sensation	246.09	22.76	924	642799	68288	109877288
Respiratory distress	244.84	22.76	51	643672	68823	109876753
Dry mouth	242.61	22.76	499	643224	199449	109746127
Arrhythmia	242.28	22.76	54	643669	69521	109876055
Gait inability	240.51	22.76	263	643460	136113	109809463
Anxiety	240.34	22.76	1111	642612	343967	109601609
Psychotic disorder	239.82	22.76	14	643709	50923	109894653
Pneumonitis	238.75	22.76	74	643649	76457	109869119
Pulmonary hypertension	237.84	22.76	23	643700	55197	109890379
Pancreatitis acute	237.57	22.76	34	643689	60240	109885336
Cerebral haemorrhage	237.46	22.76	45	643678	64923	109880653
Osteoporosis	237.03	22.76	105	643618	87047	109858529
Angina pectoris	234.51	22.76	40	643683	62255	109883321
Blood lactate dehydrogenase increased	233.39	22.76	5	643718	44329	109901247
Multiple sclerosis relapse	232.95	22.76	15	643708	50225	109895351
Abdominal distension	232.54	22.76	414	643309	174689	109770887
Hypophagia	231.81	22.76	20	643703	52606	109892970
Pregnancy	228.84	22.76	18	643705	51049	109894527
Drug dependence	228.80	22.76	16	643707	50004	109895572
Sciatica	227.66	22.76	127	643596	92272	109853304
Colitis ulcerative	227.06	22.76	83	643640	77280	109868296
Frequent bowel movements	224.56	22.76	68	643655	71322	109874254
Cerebral infarction	222.19	22.76	22	643701	51816	109893760
Toothache	220.54	22.76	449	643274	23126	109922450
Stevens-Johnson syndrome	220.48	22.76	13	643710	46888	109898688
Mood disorder due to a general medical condition	218.38	22.76	64	643659	71	109945505
Middle insomnia	216.66	22.76	411	643312	20091	109925485
Sinus tachycardia	216.49	22.76	10	643713	44483	109901093
Nasal polyps	216.27	22.76	322	643401	12878	109932698
Eosinophilic oesophagitis	215.44	22.76	119	643604	1193	109944383
Foot deformity	214.71	22.76	18	643705	48462	109897114
Hypervolaemia	214.62	22.76	20	643703	49440	109896136
Accidental overdose	214.51	22.76	25	643698	51809	109893767
Aggression	214.32	22.76	42	643681	59168	109886408
Cerebrovascular accident	211.09	22.76	463	643260	180821	109764755
Palpitations	210.00	22.76	378	643345	158834	109786742
Pneumocystis jirovecii pneumonia	209.93	22.76	9	643714	42726	109902850
Cholelithiasis	209.53	22.76	55	643668	63367	109882209
Clostridium difficile colitis	206.20	22.76	12	643711	43766	109901810
Acute myeloid leukaemia	205.96	22.76	3	643720	38107	109907469
Injection site nodule	203.59	22.76	188	643535	4458	109941118
Ejection fraction decreased	199.52	22.76	9	643714	40871	109904705
Paranasal sinus discomfort	199.01	22.76	215	643508	6190	109939386
Haemoptysis	198.78	22.76	83	643640	71271	109874305
White blood cell count increased	198.58	22.76	163	643560	96679	109848897
Dysphagia	198.35	22.76	1552	642171	152048	109793528
Palmar-plantar erythrodysaesthesia syndrome	197.11	22.76	10	643713	41015	109904561
Eosinophil count increased	196.92	22.76	401	643322	20657	109924919
Balance disorder	196.60	22.76	233	643490	116327	109829249
Subdural haematoma	196.45	22.76	3	643720	36451	109909125
Bacteraemia	195.52	22.76	13	643710	42377	109903199
Asthenopia	193.60	22.76	155	643568	3009	109942567
Memory impairment	193.45	22.76	549	643174	196395	109749181
Coagulopathy	193.35	22.76	11	643712	40900	109904676
Dandruff	192.90	22.76	83	643640	450	109945126
Cellulitis	192.84	22.76	271	643452	125745	109819831
Disease recurrence	192.82	22.76	57	643666	60727	109884849
Dyskinesia	191.54	22.76	34	643689	51412	109894164
Swelling	191.08	22.76	1227	642496	349814	109595762
Off label use	190.67	22.76	6983	636740	1493202	108452374
Periorbital inflammation	190.36	22.76	69	643654	214	109945362
Intentional self-injury	190.35	22.76	6	643717	37423	109908153
Muscle spasticity	189.26	22.76	4	643719	35911	109909665
Onychomadesis	189.03	22.76	22	643701	45641	109899935
General physical condition abnormal	188.73	22.76	227	643496	7363	109938213
Laboratory test abnormal	188.16	22.76	19	643704	44060	109901516
Diabetic ketoacidosis	187.97	22.76	15	643708	42043	109903533
Lower limb fracture	187.90	22.76	102	643621	75246	109870330
Autoimmune disorder	187.59	22.76	73	643650	65410	109880166
Eyelid pain	187.58	22.76	91	643632	678	109944898
Myelodysplastic syndrome	187.15	22.76	7	643716	37477	109908099
Haematoma	187.03	22.76	54	643669	58422	109887154
Hallucination, visual	186.10	22.76	11	643712	39594	109905982
Blood pressure diastolic decreased	185.25	22.76	5	643718	35880	109909696
Skin mass	185.10	22.76	256	643467	9560	109936016
Pallor	184.59	22.76	50	643673	56417	109889159
Diabetes mellitus	183.84	22.76	184	643539	99197	109846379
Respiration abnormal	183.74	22.76	255	643468	9554	109936022
Drug withdrawal syndrome	183.71	22.76	9	643714	38045	109907531
Facial discomfort	183.18	22.76	73	643650	314	109945262
Injection site discharge	182.74	22.76	111	643612	1349	109944227
Proteinuria	182.46	22.76	13	643710	40005	109905571
Posterior reversible encephalopathy syndrome	181.57	22.76	3	643720	33858	109911718
Fluid retention	180.96	22.76	169	643554	94138	109851438
Lip dry	180.93	22.76	189	643534	99894	109845682
Circulatory collapse	179.76	22.76	20	643703	42973	109902603
Device related infection	179.72	22.76	13	643710	39506	109906070
Tachypnoea	179.04	22.76	13	643710	39382	109906194
Exposure during pregnancy	178.59	22.76	448	643275	166976	109778600
Lupus-like syndrome	178.32	22.76	16	643707	40776	109904800
Hyperlipidaemia	177.93	22.76	7	643716	35841	109909735
Myoclonus	176.63	22.76	3	643720	32995	109912581
Aphasia	175.34	22.76	62	643661	58935	109886641
Exostosis	174.11	22.76	29	643694	45927	109899649
Lupus vulgaris	173.88	22.76	5	643718	33878	109911698
Drug effective for unapproved indication	173.82	22.76	303	643420	13864	109931712
Inappropriate antidiuretic hormone secretion	173.70	22.76	5	643718	33846	109911730
Hepatic steatosis	171.85	22.76	37	643686	48794	109896782
Finger deformity	169.39	22.76	5	643718	33087	109912489
Treatment noncompliance	169.02	22.76	108	643615	72882	109872694
Electrolyte imbalance	168.91	22.76	12	643711	37016	109908560
Metastases to liver	168.83	22.76	9	643714	35377	109910199
Retinitis	168.79	22.76	4	643719	32323	109913253
Miliaria	168.45	22.76	117	643606	1812	109943764
Rosacea	168.39	22.76	179	643544	5057	109940519
Ischaemic stroke	168.05	22.76	21	643702	41242	109904334
Mitral valve incompetence	167.17	22.76	6	643717	33323	109912253
Atelectasis	167.17	22.76	12	643711	36700	109908876
Lymphopenia	167.17	22.76	19	643704	40151	109905425
Gastrooesophageal reflux disease	167.13	22.76	515	643208	179461	109766115
Nail disorder	166.93	22.76	64	643659	57871	109887705
Superficial injury of eye	165.52	22.76	69	643654	341	109945235
Oropharyngeal discomfort	165.03	22.76	249	643474	10078	109935498
Injury associated with device	164.64	22.76	163	643560	4226	109941350
Status epilepticus	164.49	22.76	4	643719	31567	109914009
Basal cell carcinoma	164.08	22.76	32	643691	45238	109900338
Clostridium difficile infection	163.33	22.76	50	643673	52079	109893497
Intestinal obstruction	163.29	22.76	53	643670	53174	109892402
Device dislocation	161.53	22.76	5	643718	31699	109913877
Skin texture abnormal	161.09	22.76	74	643649	480	109945096
Spinal operation	160.55	22.76	254	643469	10718	109934858
Dysgeusia	160.09	22.76	105	643618	69880	109875696
Nasal polypectomy	160.00	22.76	44	643679	30	109945546
Coeliac disease	159.79	22.76	29	643694	43158	109902418
Peritonitis	159.73	22.76	7	643716	32600	109912976
Blood calcium decreased	159.59	22.76	13	643710	35832	109909744
Anaphylactic shock	158.71	22.76	51	643672	51495	109894081
Therapy partial responder	158.14	22.76	16	643707	37045	109908531
Hemiparesis	157.11	22.76	32	643691	43871	109901705
Metastases to bone	156.14	22.76	6	643717	31366	109914210
Ileus	156.01	22.76	5	643718	30724	109914852
Body temperature increased	155.07	22.76	62	643661	54651	109890925
Drainage	154.77	22.76	58	643665	203	109945373
Bronchopulmonary aspergillosis	154.76	22.76	4	643719	29859	109915717
Gait disturbance	154.65	22.76	966	642757	277242	109668334
Sunburn	154.33	22.76	160	643563	4388	109941188
Subarachnoid haemorrhage	153.85	22.76	4	643719	29698	109915878
Pharyngeal swelling	152.41	22.76	261	643462	11771	109933805
Body temperature decreased	152.38	22.76	18	643705	36917	109908659
Pericardial effusion	150.83	22.76	72	643651	57145	109888431
Pulmonary arterial hypertension	150.18	22.76	10	643713	32558	109913018
Maternal exposure during pregnancy	150.09	22.76	869	642854	254014	109691562
Injection site induration	149.59	22.76	251	643472	11132	109934444
Pustule	148.17	22.76	139	643584	3365	109942211
Iron deficiency anaemia	147.58	22.76	9	643714	31550	109914026
Polyneuropathy	147.11	22.76	10	643713	32002	109913574
Femur fracture	146.07	22.76	39	643684	44430	109901146
Adrenal insufficiency	145.39	22.76	34	643689	42356	109903220
Drug tolerance decreased	145.39	22.76	3	643720	27537	109918039
Adverse drug reaction	145.20	22.76	244	643479	105315	109840261
Poisoning	143.39	22.76	6	643717	29099	109916477
Obstructive airways disorder	143.27	22.76	45	643678	46104	109899472
Cytopenia	142.63	22.76	8	643715	30108	109915468
Ataxia	142.58	22.76	8	643715	30100	109915476
Hypoaesthesia	142.53	22.76	1157	642566	313066	109632510
Sensitivity to weather change	142.41	22.76	229	643494	9799	109935777
Blood albumin decreased	142.20	22.76	4	643719	27648	109917928
Full blood count decreased	141.92	22.76	12	643711	32087	109913489
Needle issue	141.77	22.76	318	643405	17522	109928054
Hand-foot-and-mouth disease	141.71	22.76	75	643648	685	109944891
Heart rate increased	140.45	22.76	402	643321	143432	109802144
Neutrophil count increased	140.23	22.76	18	643705	34634	109910942
Hypoalbuminaemia	139.40	22.76	7	643716	28967	109916609
Cystitis	139.34	22.76	108	643615	65928	109879648
Leukocytosis	138.46	22.76	70	643653	53758	109891818
Hypothermia	138.32	22.76	3	643720	26299	109919277
Thrombosis	137.94	22.76	264	643459	108398	109837178
Road traffic accident	137.15	22.76	260	643463	107138	109838438
Premature delivery	136.68	22.76	11	643712	30621	109914955
Cardiomyopathy	136.68	22.76	17	643706	33508	109912068
Osteonecrosis	135.41	22.76	18	643705	33723	109911853
Diabetes mellitus inadequate control	134.81	22.76	10	643713	29765	109915811
Myositis	133.90	22.76	13	643710	31103	109914473
Drug eruption	133.27	22.76	73	643650	53586	109891990
Myocardial ischaemia	133.16	22.76	5	643718	26679	109918897
Right ventricular failure	132.57	22.76	4	643719	25950	109919626
Skin warm	132.41	22.76	211	643512	8959	109936617
Small intestinal obstruction	132.15	22.76	16	643707	32197	109913379
Hallucination, auditory	131.54	22.76	5	643718	26392	109919184
Nephropathy toxic	131.06	22.76	7	643716	27471	109918105
Urinary incontinence	128.29	22.76	61	643662	48526	109897050
Rash papular	127.99	22.76	403	643320	27236	109918340
Arteriosclerosis coronary artery	127.83	22.76	4	643719	25114	109920462
Glomerular filtration rate decreased	127.55	22.76	11	643712	28945	109916631
Hypertransaminasaemia	126.65	22.76	3	643720	24252	109921324
Pigmentation disorder	126.51	22.76	183	643540	7128	109938448
Urosepsis	126.42	22.76	15	643708	30660	109914916
Brain oedema	126.22	22.76	16	643707	31082	109914494
Muscle spasms	125.31	22.76	1026	642697	277131	109668445
Skin erosion	124.65	22.76	162	643561	5692	109939884
Red blood cell sedimentation rate abnormal	124.38	22.76	4	643719	24505	109921071
Delusion	123.80	22.76	3	643720	23752	109921824
Chills	123.06	22.76	630	643093	189950	109755626
Restlessness	122.57	22.76	89	643634	56170	109889406
Abnormal behaviour	121.31	22.76	38	643685	39001	109906575
Poor venous access	121.00	22.76	5	643718	24517	109921059
Myopathy	120.18	22.76	6	643717	24954	109920622
Gastric disorder	120.01	22.76	24	643699	33333	109912243
Chapped lips	118.87	22.76	117	643606	3011	109942565
Haemodynamic instability	118.86	22.76	3	643720	22885	109922691
Dystonia	118.76	22.76	8	643715	25797	109919779
Left ventricular dysfunction	118.64	22.76	4	643719	23489	109922087
Anaphylactic reaction	117.91	22.76	311	643412	113989	109831587
Infection	117.76	22.76	1445	642278	360755	109584821
Tricuspid valve incompetence	117.35	22.76	5	643718	23868	109921708
Abdominal pain upper	117.24	22.76	1383	642340	347728	109597848
Periorbital pain	116.70	22.76	47	643676	209	109945367
Metastases to lung	116.21	22.76	4	643719	23059	109922517
Lip erythema	115.88	22.76	58	643665	466	109945110
Transient ischaemic attack	115.44	22.76	121	643602	63861	109881715
Cardiac failure acute	115.26	22.76	6	643717	24072	109921504
Aspergillus infection	114.86	22.76	9	643714	25607	109919969
Metastases to central nervous system	114.82	22.76	4	643719	22813	109922763
Injection site eczema	114.41	22.76	37	643686	71	109945505
Device operational issue	114.00	22.76	75	643648	1057	109944519
Gastroenteritis	113.22	22.76	42	643681	38758	109906818
Gastric ulcer	113.08	22.76	45	643678	39782	109905794
Pyelonephritis	112.85	22.76	9	643714	25241	109920335
Coordination abnormal	112.73	22.76	9	643714	25219	109920357
Exfoliative rash	112.43	22.76	136	643587	4438	109941138
Paranoia	112.32	22.76	4	643719	22370	109923206
Toxic skin eruption	112.06	22.76	14	643709	27501	109918075
Onychomycosis	111.95	22.76	42	643681	38489	109907087
Injection site hypoaesthesia	111.61	22.76	62	643661	629	109944947
Blood potassium increased	111.43	22.76	28	643695	33221	109912355
Emotional distress	111.40	22.76	61	643662	44786	109900790
Blood potassium decreased	111.04	22.76	91	643632	54023	109891553
Sudden death	111.00	22.76	8	643715	24387	109921189
Malnutrition	110.80	22.76	14	643709	27265	109918311
Disability	110.31	22.76	21	643702	30202	109915374
Withdrawal syndrome	109.97	22.76	24	643699	31356	109914220
Osteomyelitis	109.56	22.76	38	643685	36562	109909014
Cutaneous T-cell lymphoma	109.38	22.76	116	643607	3268	109942308
Cardiomegaly	108.99	22.76	19	643704	29111	109916465
Lethargy	108.89	22.76	239	643484	93337	109852239
Skin atrophy	108.80	22.76	161	643562	6403	109939173
Dysuria	108.57	22.76	114	643609	60117	109885459
Troponin increased	107.97	22.76	21	643702	29745	109915831
Atrial flutter	107.46	22.76	9	643714	24253	109921323
Adverse reaction	107.09	22.76	21	643702	29573	109916003
Acute coronary syndrome	106.85	22.76	7	643716	23105	109922471
Haemorrhoids	106.84	22.76	37	643686	35635	109909941
Oral candidiasis	106.72	22.76	64	643659	44696	109900880
Lack of administration site rotation	106.26	22.76	38	643685	112	109945464
Muscle rigidity	106.20	22.76	9	643714	24022	109921554
Transfusion	106.11	22.76	12	643711	25460	109920116
Abdominal pain lower	106.07	22.76	42	643681	37241	109908335
Nasal dryness	104.88	22.76	147	643576	5559	109940017
Skin depigmentation	104.80	22.76	75	643648	1221	109944355
Enterococcal infection	104.53	22.76	3	643720	20363	109925213
Haemolytic anaemia	104.12	22.76	4	643719	20916	109924660
Aspiration	103.71	22.76	25	643698	30508	109915068
Platelet count increased	103.44	22.76	15	643708	26319	109919257
Splenomegaly	103.43	22.76	11	643712	24487	109921089
Cholecystitis	103.41	22.76	14	643709	25868	109919708
Therapeutic product effect incomplete	103.32	22.76	820	642903	222985	109722591
Face oedema	103.25	22.76	33	643690	33436	109912140
Hydronephrosis	102.68	22.76	4	643719	20661	109924915
Dermatitis contact	102.36	22.76	241	643482	13712	109931864
Contusion	102.27	22.76	867	642856	232494	109713082
Sinus disorder	101.01	22.76	418	643305	32310	109913266
End stage renal disease	100.78	22.76	6	643717	21467	109924109
Eosinophilic granulomatosis with polyangiitis	100.52	22.76	204	643519	10482	109935094
Nasal operation	100.04	22.76	48	643675	348	109945228
Schizophrenia	99.77	22.76	7	643716	21819	109923757
Duodenal ulcer	99.70	22.76	3	643720	19511	109926065
Injection site scar	99.21	22.76	69	643654	1071	109944505
Ear infection	98.87	22.76	665	643058	62067	109883509
Joint dislocation	98.12	22.76	38	643685	34152	109911424
Vitreous floaters	97.61	22.76	184	643539	8950	109936626
Rales	97.38	22.76	14	643709	24725	109920851
Inflammation	97.28	22.76	691	643032	192547	109753029
Cardiac murmur	96.80	22.76	14	643709	24614	109920962
Allergy to animal	96.76	22.76	84	643639	1832	109943744
Hypogammaglobulinaemia	96.11	22.76	5	643718	20071	109925505
Mydriasis	96.02	22.76	9	643714	22148	109923428
Eosinophilic pneumonia	95.82	22.76	160	643563	7067	109938509
Blood test abnormal	95.78	22.76	24	643699	28530	109917046
Knee operation	95.17	22.76	157	643566	6865	109938711
Lipase increased	94.93	22.76	3	643720	18669	109926907
Nightmare	94.88	22.76	54	643669	38809	109906767
Oliguria	94.84	22.76	3	643720	18654	109926922
Cyanosis	94.13	22.76	28	643695	29713	109915863
Hyperthermia	93.92	22.76	8	643715	21264	109924312
Myocarditis	93.84	22.76	29	643694	30026	109915550
Mood altered	93.82	22.76	306	643417	21069	109924507
Skin necrosis	92.53	22.76	9	643714	21503	109924073
Hepatitis acute	92.01	22.76	4	643719	18762	109926814
Renal injury	91.72	22.76	4	643719	18709	109926867
Fear	91.59	22.76	13	643710	23180	109922396
Supraventricular tachycardia	91.22	22.76	16	643707	24406	109921170
Hypertensive crisis	90.96	22.76	16	643707	24356	109921220
Acute generalised exanthematous pustulosis	90.77	22.76	10	643713	21654	109923922
Scar	90.30	22.76	259	643464	16622	109928954
Disturbance in attention	90.25	22.76	138	643585	61857	109883719
Swelling face	90.02	22.76	877	642846	91444	109854132
Infusion site reaction	89.33	22.76	3	643720	17679	109927897
Benign prostatic hyperplasia	89.03	22.76	4	643719	18230	109927346
Motor dysfunction	88.98	22.76	17	643706	24389	109921187
Radiculopathy	88.97	22.76	6	643717	19330	109926246
Back injury	88.52	22.76	87	643636	47312	109898264
Dyshidrotic eczema	88.45	22.76	55	643668	699	109944877
Respiratory rate increased	88.27	22.76	19	643704	25064	109920512
Blood loss anaemia	87.86	22.76	4	643719	18021	109927555
Injection site indentation	87.78	22.76	40	643683	254	109945322
Speech disorder	87.77	22.76	139	643584	61430	109884146
Peripheral swelling	87.24	22.76	1742	641981	402292	109543284
Skin wound	87.08	22.76	83	643640	2051	109943525
Klebsiella infection	87.05	22.76	8	643715	20001	109925575
Eyelid thickening	86.49	22.76	28	643695	54	109945522
Presyncope	86.47	22.76	94	643629	48793	109896783
Taste disorder	86.40	22.76	155	643568	65232	109880344
Colitis ischaemic	86.32	22.76	4	643719	17746	109927830
Blood pressure diastolic increased	86.06	22.76	6	643717	18801	109926775
Visual acuity reduced	85.54	22.76	40	643683	32133	109913443
COVID-19 pneumonia	84.58	22.76	56	643667	37087	109908489
Ventricular extrasystoles	84.20	22.76	15	643708	22626	109922950
Peripheral sensory neuropathy	83.67	22.76	3	643720	16677	109928899
Ear discomfort	83.29	22.76	195	643528	11054	109934522
Drug tolerance	83.13	22.76	3	643720	16582	109928994
Infection parasitic	82.26	22.76	56	643667	838	109944738
Cholangitis	81.72	22.76	3	643720	16332	109929244
Hyperthyroidism	81.55	22.76	34	643689	29227	109916349
Eczema asteatotic	81.54	22.76	54	643669	770	109944806
Back pain	81.46	22.76	1595	642128	369401	109576175
Ocular surface disease	81.19	22.76	33	643690	151	109945425
Vaginal discharge	81.12	22.76	6	643717	17902	109927674
Spinal compression fracture	80.97	22.76	7	643716	18385	109927191
Anal incontinence	80.72	22.76	15	643708	21949	109923627
Hemiplegia	80.70	22.76	17	643706	22765	109922811
Nervous system disorder	80.47	22.76	42	643681	31679	109913897
Breath sounds abnormal	80.25	22.76	24	643699	25380	109920196
Epstein-Barr virus infection	80.18	22.76	8	643715	18730	109926846
Foetal death	80.09	22.76	3	643720	16042	109929534
Intestinal perforation	79.82	22.76	13	643710	20931	109924645
Vascular device infection	79.40	22.76	4	643719	16508	109929068
Hyperhidrosis	79.32	22.76	702	643021	186596	109758980
Mania	79.05	22.76	13	643710	20783	109924793
Molluscum contagiosum	78.97	22.76	48	643675	584	109944992
Increased viscosity of upper respiratory secretion	78.97	22.76	48	643675	584	109944992
Pharyngeal oedema	78.94	22.76	4	643719	16424	109929152
Immunodeficiency	78.83	22.76	66	643657	38772	109906804
Urine output decreased	78.82	22.76	11	643712	19865	109925711
Walking aid user	78.64	22.76	24	643699	25051	109920525
Respiratory syncytial virus infection	78.23	22.76	223	643500	14261	109931315
Renal disorder	78.10	22.76	104	643619	49375	109896201
Keratitis	77.93	22.76	121	643602	5023	109940553
Bronchiectasis	77.86	22.76	59	643664	36434	109909142
Ulcer haemorrhage	77.61	22.76	18	643705	22553	109923023
Joint effusion	77.42	22.76	14	643709	20891	109924685
Large intestine perforation	76.99	22.76	5	643718	16624	109928952
Hip arthroplasty	76.76	22.76	129	643594	55684	109889892
Blood triglycerides increased	76.68	22.76	22	643701	23904	109921672
Myasthenia gravis	76.30	22.76	16	643707	21495	109924081
Escherichia infection	76.14	22.76	22	643701	23794	109921782
Arteriosclerosis	75.37	22.76	25	643698	24742	109920834
Pneumothorax	75.34	22.76	57	643666	35228	109910348
Vaginal haemorrhage	75.11	22.76	26	643697	25048	109920528
Tenosynovitis	75.08	22.76	5	643718	16278	109929298
Pseudomonas infection	75.03	22.76	34	643689	27819	109917757
Appendicitis	74.74	22.76	36	643687	28428	109917148
Blood uric acid increased	74.37	22.76	17	643706	21512	109924064
Device dispensing error	74.23	22.76	33	643690	196	109945380
Skin hypertrophy	74.07	22.76	117	643606	4930	109940646
Swollen tongue	72.87	22.76	151	643572	60211	109885365
Enteritis	72.76	22.76	12	643711	19144	109926432
Neck pain	72.33	22.76	420	643303	122710	109822866
Affect lability	72.32	22.76	11	643712	18626	109926950
Osteopenia	71.96	22.76	20	643703	22189	109923387
Hepatomegaly	71.82	22.76	18	643705	21396	109924180
Spinal osteoarthritis	71.62	22.76	15	643708	20168	109925408
Blood calcium increased	71.50	22.76	10	643713	18030	109927546
Viral infection	71.37	22.76	542	643181	52597	109892979
Odynophagia	71.26	22.76	212	643511	13889	109931687
Dermatitis bullous	71.19	22.76	9	643714	17520	109928056
Encephalitis	71.12	22.76	12	643711	18827	109926749
Central nervous system lesion	71.06	22.76	5	643718	15548	109930028
Faeces discoloured	71.01	22.76	56	643667	33892	109911684
Flank pain	71.00	22.76	23	643700	23107	109922469
Staphylococcal sepsis	70.79	22.76	9	643714	17445	109928131
Sinusitis	70.60	22.76	2243	641480	294445	109651131
Nasal pruritus	70.56	22.76	52	643671	888	109944688
Musculoskeletal disorder	70.53	22.76	22	643701	22642	109922934
Pulmonary haemorrhage	70.48	22.76	7	643716	16449	109929127
Anhedonia	70.37	22.76	5	643718	15423	109930153
Sensory loss	70.13	22.76	19	643704	21438	109924138
Gangrene	69.86	22.76	7	643716	16334	109929242
Iron deficiency	69.24	22.76	12	643711	18464	109927112
Sinus headache	68.84	22.76	125	643598	5907	109939669
Pleuritic pain	68.78	22.76	7	643716	16133	109929443
Incorrect dose administered by product	68.46	22.76	33	643690	242	109945334
Product complaint	68.43	22.76	3	643720	13969	109931607
Keratoconus	68.35	22.76	29	643694	151	109945425
Diverticulum	68.11	22.76	6	643717	15520	109930056
Lung infiltration	68.02	22.76	29	643694	24599	109920977
Exposure via eye contact	67.84	22.76	17	643706	3	109945573
Cardiac failure chronic	67.53	22.76	3	643720	13808	109931768
Blood sodium decreased	67.42	22.76	74	643649	38245	109907331
Fracture	67.18	22.76	30	643693	24758	109920818
Hyperammonaemia	67.09	22.76	3	643720	13729	109931847
Fistula	66.87	22.76	6	643717	15293	109930283
Congestive cardiomyopathy	66.65	22.76	4	643719	14215	109931361
Hypotonia	66.65	22.76	7	643716	15738	109929838
Injection site hypersensitivity	66.57	22.76	77	643646	2394	109943182
Photophobia	66.51	22.76	312	643411	25459	109920117
Idiopathic urticaria	66.47	22.76	33	643690	260	109945316
Incorrect dose administered by device	66.38	22.76	132	643591	6682	109938894
Tardive dyskinesia	66.23	22.76	3	643720	13576	109932000
Neurological symptom	65.91	22.76	7	643716	15601	109929975
Throat clearing	65.75	22.76	102	643621	4231	109941345
Bone density decreased	65.73	22.76	8	643715	16034	109929542
Renal cyst	65.53	22.76	13	643710	18159	109927417
Product administration error	65.34	22.76	72	643651	37145	109908431
Complication associated with device	65.18	22.76	18	643705	20055	109925521
Diffuse large B-cell lymphoma	64.96	22.76	8	643715	15890	109929686
Faecaloma	64.75	22.76	6	643717	14902	109930674
Embolism	64.63	22.76	9	643714	16280	109929296
Mouth ulceration	64.61	22.76	113	643610	48025	109897551
Blood lactic acid increased	64.55	22.76	8	643715	15813	109929763
Chromaturia	64.54	22.76	46	643677	29314	109916262
Vasculitis	64.54	22.76	68	643655	35805	109909771
Enterobiasis	64.39	22.76	22	643701	54	109945522
Haemorrhagic stroke	64.27	22.76	4	643719	13785	109931791
Aphonia	63.72	22.76	192	643531	12668	109932908
Shoulder operation	63.69	22.76	89	643634	3356	109942220
Facial paralysis	63.01	22.76	31	643692	24183	109921393
Skin wrinkling	62.60	22.76	60	643663	1493	109944083
Seborrhoeic dermatitis	62.52	22.76	78	643645	2629	109942947
Menstruation delayed	62.48	22.76	64	643659	1730	109943846
Product administered to patient of inappropriate age	62.47	22.76	142	643581	7894	109937682
Staphylococcal bacteraemia	62.18	22.76	11	643712	16677	109928899
Eye operation	61.84	22.76	77	643646	2590	109942986
Generalised oedema	61.31	22.76	53	643670	30651	109914925
Ecchymosis	61.29	22.76	13	643710	17325	109928251
Panniculitis	60.91	22.76	9	643714	15573	109930003
Forced expiratory volume decreased	60.89	22.76	4	643719	13172	109932404
Bladder cancer	60.85	22.76	21	643702	20271	109925305
Large intestine polyp	60.82	22.76	8	643715	15109	109930467
Mental impairment	60.42	22.76	28	643695	22611	109922965
Aortic stenosis	60.24	22.76	4	643719	13055	109932521
Failure to thrive	60.22	22.76	5	643718	13569	109932007
Bone disorder	60.08	22.76	24	643699	21168	109924408
Tinnitus	59.97	22.76	168	643555	60372	109885204
Ulcer	59.90	22.76	99	643624	43017	109902559
Decubitus ulcer	59.88	22.76	16	643707	18220	109927356
Heart rate irregular	59.41	22.76	67	643656	34207	109911369
Temperature regulation disorder	58.96	22.76	4	643719	12822	109932754
Skin tightness	58.66	22.76	112	643611	5501	109940075
Coronary artery stenosis	58.54	22.76	6	643717	13752	109931824
Electrocardiogram abnormal	58.51	22.76	18	643705	18691	109926885
Gastric haemorrhage	58.21	22.76	11	643712	15904	109929672
Mixed liver injury	57.85	22.76	3	643720	12076	109933500
Foreign body in eye	57.21	22.76	33	643690	362	109945214
Candida infection	57.19	22.76	121	643602	47888	109897688
Bronchospasm	57.05	22.76	55	643668	30184	109915392
Haemorrhage	56.91	22.76	375	643348	106317	109839259
Rebound nasal congestion	56.67	22.76	19	643704	43	109945533
Skin hypopigmentation	56.50	22.76	55	643668	1396	109944180
Cardiovascular disorder	56.46	22.76	31	643692	22729	109922847
Seasonal allergy	56.30	22.76	246	643477	19476	109926100
Blood magnesium decreased	56.11	22.76	23	643700	19973	109925603
Bundle branch block right	56.01	22.76	4	643719	12287	109933289
Vitamin D deficiency	55.98	22.76	19	643704	18533	109927043
Ileus paralytic	55.95	22.76	3	643720	11734	109933842
Bradyphrenia	55.90	22.76	3	643720	11725	109933851
Eczema herpeticum	55.87	22.76	35	643688	451	109945125
Chest discomfort	55.86	22.76	1366	642357	172482	109773094
Apathy	55.74	22.76	13	643710	16226	109929350
Proctalgia	55.66	22.76	6	643717	13216	109932360
Laryngitis	55.62	22.76	101	643622	42310	109903266
Prostate cancer	55.55	22.76	83	643640	37558	109908018
Acarodermatitis	55.51	22.76	63	643660	1918	109943658
Potentiating drug interaction	55.42	22.76	3	643720	11640	109933936
Dark circles under eyes	55.11	22.76	36	643687	501	109945075
Blood creatine increased	54.74	22.76	3	643720	11518	109934058
Nasal inflammation	54.40	22.76	46	643677	967	109944609
Arthropod bite	54.29	22.76	151	643572	9520	109936056
Infusion site pain	54.04	22.76	17	643706	17402	109928174
Bundle branch block left	53.87	22.76	6	643717	12882	109932694
Polyuria	53.81	22.76	18	643705	17720	109927856
Lip exfoliation	53.77	22.76	41	643682	739	109944837
Respiratory disorder	53.76	22.76	223	643500	71159	109874417
Serum ferritin increased	53.57	22.76	4	643719	11843	109933733
Hiatus hernia	53.51	22.76	49	643674	27557	109918019
Injection site injury	52.95	22.76	47	643676	1057	109944519
Anal abscess	52.43	22.76	4	643719	11634	109933942
Infusion site extravasation	52.41	22.76	4	643719	11630	109933946
Infective pulmonary exacerbation of cystic fibrosis	52.37	22.76	11	643712	14760	109930816
Injection site paraesthesia	52.13	22.76	40	643683	728	109944848
Pathological fracture	51.84	22.76	5	643718	12027	109933549
Aortic arteriosclerosis	51.51	22.76	3	643720	10935	109934641
Monocyte count increased	51.23	22.76	8	643715	13285	109932291
Skin lesion	51.08	22.76	492	643231	51139	109894437
Left ventricular hypertrophy	50.97	22.76	8	643715	13236	109932340
Pustular psoriasis	50.62	22.76	9	643714	13596	109931980
Eczema infected	50.60	22.76	24	643699	169	109945407
Post procedural haemorrhage	50.20	22.76	14	643709	15498	109930078
Cushingoid	50.11	22.76	5	643718	11707	109933869
Bacterial infection	49.99	22.76	122	643601	45914	109899662
Brain injury	49.96	22.76	9	643714	13467	109932109
Breast cancer metastatic	49.93	22.76	4	643719	11177	109934399
Nephropathy	49.91	22.76	9	643714	13458	109932118
Conjunctival papillae	49.83	22.76	12	643711	0	109945576
Metastases to lymph nodes	49.72	22.76	13	643710	15019	109930557
Breast cancer	49.47	22.76	93	643630	38449	109907127
Endocarditis	49.42	22.76	9	643714	13362	109932214
Arterial occlusive disease	49.20	22.76	14	643709	15294	109930282
Therapeutic response delayed	49.16	22.76	50	643673	1340	109944236
Skin hyperpigmentation	49.04	22.76	136	643587	8560	109937016
Ocular rosacea	49.01	22.76	14	643709	13	109945563
Adenovirus infection	48.91	22.76	4	643719	10990	109934586
Maternal exposure timing unspecified	48.77	22.76	31	643692	20982	109924594
Bacterial sepsis	48.67	22.76	3	643720	10423	109935153
Eczema weeping	48.47	22.76	15	643708	23	109945553
Protein total decreased	48.34	22.76	4	643719	10886	109934690
Tinea infection	48.08	22.76	51	643672	1437	109944139
Chronic sinusitis	48.05	22.76	45	643678	25039	109920537
Squamous cell carcinoma of skin	47.93	22.76	20	643703	17183	109928393
Hepatitis C	47.48	22.76	8	643715	12565	109933011
Colitis microscopic	47.43	22.76	10	643713	13384	109932192
Choking	47.43	22.76	194	643529	14916	109930660
Blepharospasm	47.39	22.76	162	643561	54689	109890887
Sinonasal obstruction	47.22	22.76	29	643694	360	109945216
Nystagmus	46.88	22.76	6	643717	11571	109934005
Parosmia	46.87	22.76	176	643547	13004	109932572
Dementia	46.59	22.76	70	643653	31603	109913973
Body height decreased	46.56	22.76	4	643719	10559	109935017
Pneumonia fungal	46.49	22.76	14	643709	14740	109930836
Emotional disorder	46.46	22.76	202	643521	15958	109929618
Protein urine present	46.39	22.76	6	643717	11478	109934098
Migraine	46.31	22.76	711	643012	170941	109774635
Skin discharge	46.26	22.76	22	643701	156	109945420
Coronary artery occlusion	46.14	22.76	17	643706	15755	109929821
Eczema nummular	46.14	22.76	30	643693	414	109945162
Affective disorder	45.85	22.76	157	643566	11084	109934492
Spinal stenosis	45.78	22.76	27	643696	19029	109926547
Vitiligo	45.75	22.76	71	643652	2946	109942630
Weight fluctuation	45.73	22.76	37	643686	22108	109923468
Cheilitis	45.67	22.76	109	643614	6256	109939320
Intentional product misuse	45.65	22.76	1054	642669	131850	109813726
Injection site coldness	45.52	22.76	20	643703	115	109945461
Dissociation	45.44	22.76	3	643720	9839	109935737
Cutaneous T-cell lymphoma stage IV	45.28	22.76	16	643707	45	109945531
Inflammatory marker increased	45.10	22.76	14	643709	14455	109931121
Discharge	45.01	22.76	60	643663	2162	109943414
Pneumonia bacterial	44.80	22.76	52	643671	26209	109919367
Atopic keratoconjunctivitis	44.72	22.76	15	643708	34	109945542
Escherichia bacteraemia	44.39	22.76	4	643719	10160	109935416
Deformity	44.37	22.76	4	643719	10156	109935420
Seronegative arthritis	44.34	22.76	11	643712	13166	109932410
Deafness neurosensory	44.21	22.76	3	643720	9616	109935960
Micturition urgency	44.16	22.76	29	643694	19291	109926285
Polyarthritis	43.98	22.76	28	643695	18935	109926641
Ketoacidosis	43.97	22.76	4	643719	10083	109935493
Blood thyroid stimulating hormone increased	43.94	22.76	9	643714	12292	109933284
Orthopnoea	43.94	22.76	6	643717	11015	109934561
Erythema multiforme	43.88	22.76	35	643688	21062	109924514
Incontinence	43.74	22.76	21	643702	16614	109928962
Metabolic disorder	43.66	22.76	5	643718	10505	109935071
Left ventricular failure	43.56	22.76	7	643716	11382	109934194
Hyperreflexia	43.48	22.76	3	643720	9482	109936094
Systemic candida	43.36	22.76	4	643719	9970	109935606
Thrombocytosis	43.31	22.76	5	643718	10439	109935137
Arthritis	43.25	22.76	700	643023	166886	109778690
Demyelination	43.17	22.76	3	643720	9426	109936150
Hydrocephalus	42.94	22.76	5	643718	10370	109935206
Fungal skin infection	42.50	22.76	115	643608	7134	109938442
Organising pneumonia	42.27	22.76	15	643708	14228	109931348
Lung neoplasm malignant	42.26	22.76	83	643640	33759	109911817
Carotid artery stenosis	42.25	22.76	3	643720	9260	109936316
Mouth haemorrhage	42.14	22.76	13	643710	13475	109932101
Pelvic pain	42.11	22.76	20	643703	15922	109929654
Systemic inflammatory response syndrome	41.79	22.76	12	643711	13031	109932545
Psychomotor hyperactivity	41.72	22.76	34	643689	20243	109925333
Pain in jaw	41.65	22.76	155	643568	51022	109894554
Tuberculosis	41.56	22.76	26	643697	17748	109927828
Intervertebral disc degeneration	41.54	22.76	27	643696	18058	109927518
Wrong product administered	41.33	22.76	7	643716	10953	109934623
Menstruation irregular	41.30	22.76	99	643624	5698	109939878
Alopecia	41.30	22.76	1719	642004	363034	109582542
Partial seizures	41.17	22.76	8	643715	11341	109934235
Eyelid infection	41.13	22.76	27	643696	379	109945197
Diverticulum intestinal	40.99	22.76	9	643714	11710	109933866
Lung adenocarcinoma	40.96	22.76	4	643719	9527	109936049
Oesophagitis	40.76	22.76	65	643658	28650	109916926
Diarrhoea haemorrhagic	40.73	22.76	20	643703	15619	109929957
Arthritis bacterial	40.61	22.76	7	643716	10813	109934763
Paralysis	40.55	22.76	20	643703	15580	109929996
Lip pruritus	40.42	22.76	44	643679	1278	109944298
Milk allergy	40.35	22.76	24	643699	280	109945296
Wisdom teeth removal	40.33	22.76	35	643688	763	109944813
Mass	40.28	22.76	33	643690	19597	109925979
Abscess	40.12	22.76	61	643662	27408	109918168
Oesophageal candidiasis	40.06	22.76	9	643714	11525	109934051
Gluten sensitivity	39.91	22.76	29	643694	484	109945092
Tooth disorder	39.85	22.76	69	643654	29440	109916136
Non-cardiac chest pain	39.61	22.76	6	643717	10192	109935384
Multiple sclerosis	39.56	22.76	55	643668	25643	109919933
Nocturia	39.52	22.76	25	643698	16965	109928611
Necrosis	39.41	22.76	9	643714	11397	109934179
Personality change	39.40	22.76	8	643715	10994	109934582
Mental status changes	39.37	22.76	270	643453	75852	109869724
Blood urine present	39.25	22.76	50	643673	24195	109921381
Ankylosing spondylitis	39.12	22.76	21	643702	15591	109929985
Immune thrombocytopenia	38.96	22.76	44	643679	22450	109923126
Blood creatinine decreased	38.84	22.76	4	643719	9133	109936443
Product administration interrupted	38.84	22.76	9	643714	11283	109934293
Alcohol intolerance	38.77	22.76	27	643696	420	109945156
Blood chloride decreased	38.72	22.76	4	643719	9111	109936465
Dry throat	38.54	22.76	130	643593	9108	109936468
Intercepted product dispensing error	38.49	22.76	21	643702	205	109945371
Device breakage	38.37	22.76	16	643707	13753	109931823
Sinus node dysfunction	38.35	22.76	4	643719	9043	109936533
Drug ineffective for unapproved indication	38.29	22.76	825	642898	102013	109843563
Wheezing	38.28	22.76	1835	641888	253395	109692181
Hypereosinophilic syndrome	38.28	22.76	35	643688	819	109944757
Sexual dysfunction	38.23	22.76	3	643720	8527	109937049
Hypercapnia	38.17	22.76	9	643714	11150	109934426
Venous thrombosis	38.10	22.76	3	643720	8502	109937074
Anal fissure	37.96	22.76	6	643717	9875	109935701
Dialysis	37.81	22.76	35	643688	19584	109925992
Sinus congestion	37.77	22.76	305	643418	30154	109915422
Systemic infection	37.63	22.76	6	643717	9813	109935763
Asthma exercise induced	37.56	22.76	21	643702	216	109945360
Major depression	37.47	22.76	8	643715	10613	109934963
Gastric cancer	37.41	22.76	9	643714	10999	109934577
Asphyxia	37.29	22.76	18	643705	14197	109931379
Gastroenteritis viral	37.28	22.76	310	643413	30916	109914660
Cerebral ischaemia	37.22	22.76	12	643711	12092	109933484
Oesophageal discomfort	37.18	22.76	28	643695	495	109945081
Mean cell volume increased	37.14	22.76	3	643720	8327	109937249
Hyperaesthesia teeth	37.12	22.76	56	643667	2266	109943310
Hyperlactacidaemia	36.90	22.76	3	643720	8283	109937293
Postoperative wound infection	36.89	22.76	23	643700	15730	109929846
Diverticulitis	36.79	22.76	173	643550	53349	109892227
Abnormal sensation in eye	36.78	22.76	54	643669	2132	109943444
Ammonia increased	36.70	22.76	3	643720	8247	109937329
Skin ulcer	36.65	22.76	547	643176	63098	109882478
Pulmonary tuberculosis	36.38	22.76	5	643718	9134	109936442
Post procedural complication	36.30	22.76	62	643661	26596	109918980
Pre-eclampsia	36.22	22.76	4	643719	8646	109936930
Ischaemia	36.08	22.76	5	643718	9078	109936498
Pollakiuria	35.87	22.76	134	643589	44061	109901515
Eye symptom	35.86	22.76	19	643704	174	109945402
Sticky skin	35.84	22.76	12	643711	27	109945549
Hiccups	35.79	22.76	15	643708	12854	109932722
Conjunctivitis allergic	35.78	22.76	105	643618	6826	109938750
Prostatic specific antigen increased	35.74	22.76	14	643709	12497	109933079
Eye ulcer	35.72	22.76	24	643699	351	109945225
Hyperpyrexia	35.72	22.76	3	643720	8066	109937510
Fibrin D dimer increased	35.59	22.76	7	643716	9838	109935738
Enthesopathy	35.59	22.76	14	643709	12464	109933112
Throat irritation	35.56	22.76	472	643251	53080	109892496
Autoimmune hepatitis	35.53	22.76	21	643702	14783	109930793
Menstrual disorder	35.50	22.76	83	643640	4701	109940875
Laryngeal oedema	35.40	22.76	7	643716	9800	109935776
Renal function test abnormal	35.36	22.76	5	643718	8941	109936635
Circumoral swelling	35.35	22.76	14	643709	59	109945517
Dermatitis exfoliative	35.33	22.76	11	643712	11336	109934240
Periorbital disorder	34.99	22.76	14	643709	61	109945515
Procedural complication	34.91	22.76	4	643719	8401	109937175
Peripheral arterial occlusive disease	34.83	22.76	6	643717	9274	109936302
Abdominal abscess	34.69	22.76	5	643718	8814	109936762
Dacryostenosis acquired	34.57	22.76	30	643693	654	109944922
Head injury	34.54	22.76	131	643592	42886	109902690
Musculoskeletal discomfort	34.41	22.76	245	643478	23293	109922283
Hepatitis B	34.40	22.76	7	643716	9605	109935971
Metastasis	34.17	22.76	4	643719	8263	109937313
Exposure to extreme temperature	34.17	22.76	10	643713	11	109945565
Carotid artery occlusion	34.16	22.76	7	643716	9558	109936018
Tongue oedema	34.11	22.76	4	643719	8252	109937324
Loss of personal independence in daily activities	34.05	22.76	1128	642595	148892	109796684
Inappropriate schedule of product discontinuation	34.04	22.76	15	643708	87	109945489
Colorectal cancer	33.98	22.76	6	643717	9108	109936468
Croup infectious	33.95	22.76	36	643687	1014	109944562
Atrioventricular block	33.86	22.76	29	643694	16848	109928728
Allergy to metals	33.78	22.76	31	643692	729	109944847
Decreased activity	33.74	22.76	140	643583	10834	109934742
Blood glucose decreased	33.74	22.76	76	643647	29412	109916164
Furuncle	33.57	22.76	119	643604	8549	109937027
Blood phosphorus decreased	33.52	22.76	3	643720	7662	109937914
Tongue disorder	33.31	22.76	21	643702	14277	109931299
Peptic ulcer	33.27	22.76	3	643720	7616	109937960
Paraesthesia	33.26	22.76	1294	642429	275227	109670349
Haemorrhoidal haemorrhage	33.25	22.76	4	643719	8089	109937487
Supraventricular extrasystoles	33.14	22.76	4	643719	8069	109937507
Skin indentation	33.08	22.76	11	643712	24	109945552
Chest X-ray abnormal	32.95	22.76	5	643718	8482	109937094
Herpes ophthalmic	32.79	22.76	47	643676	1815	109943761
Oesophageal carcinoma	32.75	22.76	13	643710	11511	109934065
Diplopia	32.73	22.76	129	643594	41765	109903811
Hepatic cancer	32.68	22.76	12	643711	11144	109934432
Foetal exposure during pregnancy	32.65	22.76	3	643720	7502	109938074
Bacterial test positive	32.63	22.76	4	643719	7973	109937603
Humerus fracture	32.58	22.76	11	643712	10765	109934811
Skin plaque	32.56	22.76	153	643570	12492	109933084
Salivary hypersecretion	32.50	22.76	32	643691	17389	109928187
Gastrointestinal perforation	32.39	22.76	3	643720	7453	109938123
Neck surgery	32.35	22.76	50	643673	2067	109943509
Pulmonary mass	32.33	22.76	110	643613	37191	109908385
Pain	32.26	22.76	4973	638750	949982	108995594
Oral mucosal eruption	32.25	22.76	37	643686	1140	109944436
Product availability issue	32.17	22.76	4	643719	7886	109937690
Defaecation urgency	32.09	22.76	6	643717	8741	109936835
Haemoglobin increased	32.04	22.76	7	643716	9140	109936436
Quality of life decreased	31.90	22.76	165	643558	14004	109931572
Gynaecomastia	31.78	22.76	8	643715	9482	109936094
Pancreatic carcinoma	31.78	22.76	24	643699	14848	109930728
Intestinal haemorrhage	31.76	22.76	3	643720	7338	109938238
Thinking abnormal	31.63	22.76	25	643698	15115	109930461
Dysstasia	31.60	22.76	93	643630	32893	109912683
Infusion site erythema	31.59	22.76	15	643708	11944	109933632
Seborrhoea	31.58	22.76	26	643697	526	109945050
Burns second degree	31.33	22.76	4	643719	7729	109937847
Sleep apnoea syndrome	31.31	22.76	125	643598	40322	109905254
Hepatic enzyme abnormal	31.25	22.76	9	643714	9754	109935822
Peripheral vascular disorder	31.21	22.76	6	643717	8570	109937006
Limb operation	31.16	22.76	71	643652	3953	109941623
Gingival bleeding	31.00	22.76	42	643681	19797	109925779
Sweating fever	30.97	22.76	14	643709	87	109945489
Bradykinesia	30.94	22.76	12	643711	10776	109934800
Vitamin B12 deficiency	30.86	22.76	10	643713	10045	109935531
B-cell lymphoma	30.75	22.76	3	643720	7151	109938425
Guillain-Barre syndrome	30.73	22.76	12	643711	10732	109934844
Helminthic infection	30.71	22.76	14	643709	89	109945487
Exposure to fungus	30.71	22.76	18	643705	204	109945372
Steroid dependence	30.66	22.76	6	643717	8463	109937113
Neutrophilia	30.44	22.76	11	643712	10318	109935258
Hot flush	30.43	22.76	242	643481	65794	109879782
Bone lesion	30.39	22.76	3	643720	7084	109938492
Gout	30.24	22.76	110	643613	36456	109909120
Portal vein thrombosis	30.23	22.76	3	643720	7055	109938521
Muscle atrophy	30.15	22.76	20	643703	13234	109932342
Haemorrhagic diathesis	30.14	22.76	4	643719	7504	109938072
Aortic aneurysm	30.13	22.76	10	643713	9894	109935682
Dermatitis psoriasiform	30.13	22.76	66	643657	3578	109941998
Dyspnoea at rest	30.03	22.76	6	643717	8340	109937236
Polymenorrhoea	29.74	22.76	35	643688	1109	109944467
Erysipelas	29.74	22.76	20	643703	13138	109932438
Paradoxical drug reaction	29.72	22.76	10	643713	9807	109935769
Blindness	29.66	22.76	110	643613	36249	109909327
Norovirus infection	29.65	22.76	51	643672	2308	109943268
Deafness	29.62	22.76	70	643653	26639	109918937
Ageusia	29.61	22.76	206	643517	19439	109926137
Haemoglobin abnormal	29.54	22.76	8	643715	9030	109936546
Crepitations	29.54	22.76	13	643710	10822	109934754
Gestational diabetes	29.51	22.76	4	643719	7385	109938191
Pneumonia viral	29.46	22.76	14	643709	11143	109934433
Joint injury	29.46	22.76	126	643597	39868	109905708
Neurological decompensation	29.29	22.76	3	643720	6880	109938696
Synovial cyst	29.19	22.76	15	643708	11415	109934161
Oligomenorrhoea	29.16	22.76	31	643692	876	109944700
Milia	29.12	22.76	14	643709	102	109945474
Product administered by wrong person	29.12	22.76	14	643709	102	109945474
Paronychia	29.12	22.76	14	643709	11067	109934509
Impetigo	29.03	22.76	53	643670	2515	109943061
Product temperature excursion issue	28.99	22.76	30	643693	821	109944755
Erythrodermic atopic dermatitis	28.86	22.76	10	643713	26	109945550
Blood thyroid stimulating hormone decreased	28.72	22.76	4	643719	7235	109938341
Brain abscess	28.70	22.76	3	643720	6771	109938805
Paranasal sinus hypersecretion	28.67	22.76	75	643648	4559	109941017
Urinary tract infection bacterial	28.61	22.76	6	643717	8061	109937515
Blood pressure inadequately controlled	28.51	22.76	5	643718	7628	109937948
Euphoric mood	28.50	22.76	8	643715	8819	109936757
Bicytopenia	28.44	22.76	3	643720	6721	109938855
Bronchopulmonary aspergillosis allergic	28.42	22.76	7	643716	8419	109937157
Vertigo	28.40	22.76	346	643377	86524	109859052
Antinuclear antibody positive	28.35	22.76	9	643714	9159	109936417
Lip oedema	28.34	22.76	5	643718	7595	109937981
Ischaemic cardiomyopathy	28.33	22.76	6	643717	8005	109937571
Infusion site swelling	28.30	22.76	11	643712	9866	109935710
Skin odour abnormal	28.19	22.76	51	643672	2403	109943173
Spinal pain	28.13	22.76	40	643683	18475	109927101
Lichenification	28.12	22.76	32	643691	977	109944599
Spinal cord compression	28.09	22.76	5	643718	7547	109938029
Cutaneous vasculitis	27.90	22.76	20	643703	12709	109932867
Renal cancer	27.90	22.76	21	643702	13013	109932563
Spinal fracture	27.84	22.76	56	643667	22577	109922999
Gastric ulcer haemorrhage	27.70	22.76	12	643711	10082	109935494
Actinic keratosis	27.53	22.76	4	643719	7009	109938567
Pre-existing condition improved	27.37	22.76	3	643720	6523	109939053
Drug dose omission by device	27.30	22.76	161	643562	14355	109931221
Breast cancer stage I	27.24	22.76	5	643718	7382	109938194
Movement disorder	27.24	22.76	114	643609	36290	109909286
Stress at work	27.18	22.76	36	643687	1289	109944287
Staphylococcus test positive	27.15	22.76	5	643718	7365	109938211
Lymphocytic infiltration	27.07	22.76	45	643678	1980	109943596
Normocytic anaemia	27.06	22.76	3	643720	6464	109939112
Hepatosplenomegaly	27.04	22.76	4	643719	6915	109938661
Squamous cell carcinoma	26.96	22.76	41	643682	18422	109927154
Hepatic lesion	26.87	22.76	8	643715	8485	109937091
Malabsorption	26.83	22.76	3	643720	6422	109939154
Abdominal tenderness	26.75	22.76	20	643703	12437	109933139
Sickle cell anaemia with crisis	26.75	22.76	11	643712	9534	109936042
Formication	26.74	22.76	83	643640	5565	109940011
Meningitis aseptic	26.66	22.76	12	643711	9858	109935718
Periorbital oedema	26.59	22.76	13	643710	10179	109935397
Gallbladder operation	26.56	22.76	49	643674	2344	109943232
Genital haemorrhage	26.55	22.76	5	643718	7247	109938329
Phlebitis	26.53	22.76	12	643711	9829	109935747
Colon cancer	26.53	22.76	34	643689	16409	109929167
Depressive symptom	26.48	22.76	8	643715	8406	109937170
Cardiac operation	26.47	22.76	86	643637	5909	109939667
Lumbar vertebral fracture	26.45	22.76	10	643713	9121	109936455
Cardiac disorder	26.41	22.76	300	643423	75980	109869596
Immunosuppression	26.36	22.76	39	643684	17720	109927856
Eye colour change	26.33	22.76	23	643700	506	109945070
Feeling cold	26.33	22.76	105	643618	33882	109911694
Eyelid cyst	26.28	22.76	15	643708	161	109945415
Abdominal operation	26.26	22.76	29	643694	856	109944720
Incoherent	26.21	22.76	8	643715	8350	109937226
Oesophageal ulcer	26.13	22.76	7	643716	7957	109937619
Ankle operation	25.91	22.76	36	643687	1350	109944226
Epigastric discomfort	25.90	22.76	10	643713	9005	109936571
Product dispensing issue	25.86	22.76	25	643698	629	109944947
Psoriasis	25.75	22.76	1028	642695	138965	109806611
Nocardiosis	25.68	22.76	6	643717	7480	109938096
Tonsillolith	25.57	22.76	8	643715	13	109945563
Dental caries	25.56	22.76	22	643701	12751	109932825
Essential hypertension	25.55	22.76	7	643716	7840	109937736
Product used for unknown indication	25.41	22.76	43	643680	1920	109943656
Nasal discharge discolouration	25.37	22.76	57	643666	3144	109942432
Eczema infantile	25.32	22.76	7	643716	5	109945571
Localised oedema	25.25	22.76	11	643712	9212	109936364
Diabetes insipidus	25.21	22.76	4	643719	6566	109939010
N-terminal prohormone brain natriuretic peptide increased	25.21	22.76	3	643720	6118	109939458
Intervertebral discitis	25.21	22.76	5	643718	6985	109938591
Emphysema	25.06	22.76	48	643675	19708	109925868
Liver abscess	25.02	22.76	7	643716	7732	109937844
Catarrh	24.92	22.76	6	643717	7329	109938247
Epistaxis	24.92	22.76	573	643150	129799	109815777
Nail cuticle fissure	24.91	22.76	6	643717	0	109945576
Swollen tear duct	24.81	22.76	9	643714	28	109945548
Rhinalgia	24.73	22.76	64	643659	3865	109941711
Stridor	24.72	22.76	5	643718	6890	109938686
Restless legs syndrome	24.64	22.76	68	643655	24558	109921018
Madarosis	24.52	22.76	59	643664	3404	109942172
Facial pain	24.40	22.76	163	643560	15176	109930400
Low density lipoprotein increased	24.39	22.76	16	643707	10650	109934926
Lymphoproliferative disorder	24.34	22.76	6	643717	7212	109938364
Injection site pustule	24.34	22.76	12	643711	93	109945483
Device failure	24.28	22.76	6	643717	7201	109938375
Therapy change	24.25	22.76	14	643709	9983	109935593
Hyperaesthesia	24.23	22.76	30	643693	14697	109930879
Impaired work ability	24.22	22.76	76	643647	26343	109919233
Pelvic fracture	24.17	22.76	28	643695	14126	109931450
Therapy interrupted	24.17	22.76	180	643543	49642	109895934
Dyspnoea exertional	24.15	22.76	443	643280	103617	109841959
Ear swelling	24.04	22.76	44	643679	2092	109943484
Asthma-chronic obstructive pulmonary disease overlap syndrome	24.04	22.76	4	643719	6340	109939236
Pemphigoid	24.04	22.76	49	643674	19658	109925918
Uveitis	23.99	22.76	57	643666	21653	109923923
Renal cell carcinoma	23.99	22.76	7	643716	7523	109938053
Lip blister	23.92	22.76	57	643666	3268	109942308
SARS-CoV-1 test positive	23.89	22.76	8	643715	18	109945558
Intracranial pressure increased	23.83	22.76	16	643707	10519	109935057
Faecal calprotectin increased	23.83	22.76	5	643718	6714	109938862
Total lung capacity decreased	23.82	22.76	6	643717	7108	109938468
Skin papilloma	23.62	22.76	91	643632	6805	109938771
Allergy to arthropod sting	23.44	22.76	18	643705	328	109945248
Hepatic cyst	23.43	22.76	8	643715	7775	109937801
Arthritis infective	23.37	22.76	16	643707	10413	109935163
Acute lymphocytic leukaemia	23.31	22.76	3	643720	5762	109939814
Alopecia areata	23.30	22.76	44	643679	2143	109943433
Thirst	23.20	22.76	58	643665	21649	109923927
Eosinophilic pneumonia chronic	23.04	22.76	22	643701	545	109945031
Pulmonary vasculitis	23.02	22.76	5	643718	6555	109939021
Mean cell haemoglobin concentration decreased	22.87	22.76	3	643720	5679	109939897
Petechiae	22.87	22.76	65	643658	23252	109922324
Facial paresis	22.84	22.76	4	643719	6109	109939467
White blood cell count abnormal	22.80	22.76	6	643717	6903	109938673
Meningioma	22.78	22.76	3	643720	5662	109939914

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D11AH05	DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Agents for dermatitis, excluding corticosteroids
FDA CS	M0001357	Antibodies, Monoclonal
FDA MoA	N0000193341	Interleukin 4 Receptor alpha Antagonists
FDA EPC	N0000193342	Interleukin-4 Receptor alpha Antagonist
CHEBI has role	CHEBI:22587	antiviral agent
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:50177	dermatologic drug
CHEBI has role	CHEBI:65023	anti-asthmatic agent
CHEBI has role	CHEBI:66981	ophthalmology drug
CHEBI has role	CHEBI:67079	anti-inflammatory agent

Related Drugs by ATC class:

D11AH Agents for dermatitis, excluding corticosteroids 11 drugs

abrocitinibalitretinoincrisaborolecromoglicic aciddelgocitiniblebrikizumabnemolizumabpimecrolimusruxolitinibtacrolimustralokinumab

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Atopic dermatitis	indication	24079001	DOID:3310
Chronic sinusitis	indication	40055000
Prurigo nodularis	indication	63501000
Asthma	indication	195967001	DOID:2841
Eosinophilic esophagitis	indication	235599003	DOID:13922

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Interleukin-4 receptor subunit alpha	Membrane receptor	P24394	IL4RA_HUMAN	ANTIBODY BINDING	IC50	11.06		IUPHAR	DRUG LABEL

External reference:

ID	Source
420K487FSG	UNII
4036554	VANDF
C3660996	UMLSCUI
CHEBI:753623	CHEBI
CHEMBL2108675	ChEMBL_ID
DB12159	DRUGBANK_ID
D10354	KEGG_DRUG
9669	INN_ID
C582203	MESH_SUPPLEMENTAL_RECORD_UI
7574	IUPHAR_LIGAND_ID
733487000	SNOMEDCT_US
763589007	SNOMEDCT_US
255128	MMSL
32580	MMSL
d08549	MMSL
017152	NDDF
1876376	RXNORM

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Dupixent	HUMAN PRESCRIPTION DRUG LABEL	1	0024-5911	INJECTION, SOLUTION	100 mg	SUBCUTANEOUS	BLA	31 sections
Dupixent	HUMAN PRESCRIPTION DRUG LABEL	1	0024-5911	INJECTION, SOLUTION	100 mg	SUBCUTANEOUS	BLA	31 sections
Dupixent	HUMAN PRESCRIPTION DRUG LABEL	1	0024-5914	INJECTION, SOLUTION	300 mg	SUBCUTANEOUS	BLA	31 sections
Dupixent	HUMAN PRESCRIPTION DRUG LABEL	1	0024-5914	INJECTION, SOLUTION	300 mg	SUBCUTANEOUS	BLA	31 sections
Dupixent	HUMAN PRESCRIPTION DRUG LABEL	1	0024-5915	INJECTION, SOLUTION	300 mg	SUBCUTANEOUS	BLA	31 sections
Dupixent	HUMAN PRESCRIPTION DRUG LABEL	1	0024-5915	INJECTION, SOLUTION	300 mg	SUBCUTANEOUS	BLA	31 sections
Dupixent	HUMAN PRESCRIPTION DRUG LABEL	1	0024-5918	INJECTION, SOLUTION	200 mg	SUBCUTANEOUS	BLA	31 sections
Dupixent	HUMAN PRESCRIPTION DRUG LABEL	1	0024-5918	INJECTION, SOLUTION	200 mg	SUBCUTANEOUS	BLA	31 sections
Dupixent	HUMAN PRESCRIPTION DRUG LABEL	1	0024-5919	INJECTION, SOLUTION	200 mg	SUBCUTANEOUS	BLA	31 sections
Dupixent	HUMAN PRESCRIPTION DRUG LABEL	1	0024-5919	INJECTION, SOLUTION	200 mg	SUBCUTANEOUS	BLA	31 sections