Stem definition | Drug id | CAS RN |
---|---|---|
immunosuppressants, rapamycin derivatives | 2168 | 137071-32-0 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.62 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 0 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 13, 2001 | FDA | VALEANT BERMUDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Application site pain | 86.44 | 23.96 | 22 | 2033 | 4161 | 53342850 |
Steroid withdrawal syndrome | 63.68 | 23.96 | 12 | 2043 | 559 | 53346452 |
Psoriasis | 60.34 | 23.96 | 39 | 2016 | 87050 | 53259961 |
Application site erythema | 54.68 | 23.96 | 16 | 2039 | 5075 | 53341936 |
Eczema | 42.35 | 23.96 | 20 | 2035 | 24162 | 53322849 |
Application site pruritus | 40.02 | 23.96 | 12 | 2043 | 4137 | 53342874 |
Application site irritation | 39.46 | 23.96 | 10 | 2045 | 1854 | 53345157 |
Dermatitis atopic | 36.59 | 23.96 | 11 | 2044 | 3823 | 53343188 |
Vulval disorder | 31.44 | 23.96 | 7 | 2048 | 747 | 53346264 |
Skin burning sensation | 31.29 | 23.96 | 13 | 2042 | 11597 | 53335414 |
Application site dryness | 28.06 | 23.96 | 5 | 2050 | 170 | 53346841 |
Application site swelling | 27.65 | 23.96 | 6 | 2049 | 568 | 53346443 |
Lymphadenopathy | 26.94 | 23.96 | 17 | 2038 | 36238 | 53310773 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Application site pain | 42.63 | 31.94 | 10 | 949 | 1764 | 32510803 |
Dermatitis atopic | 39.36 | 31.94 | 10 | 949 | 2457 | 32510110 |
Limbic encephalitis | 38.71 | 31.94 | 7 | 952 | 341 | 32512226 |
Source | Code | Description |
---|---|---|
ATC | D11AH02 | DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Agents for dermatitis, excluding corticosteroids |
FDA EPC | N0000175457 | Calcineurin Inhibitor Immunosuppressant |
FDA MoA | N0000175458 | Calcineurin Inhibitors |
MeSH PA | D000700 | Analgesics |
MeSH PA | D018712 | Analgesics, Non-Narcotic |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
MeSH PA | D018501 | Antirheumatic Agents |
MeSH PA | D065095 | Calcineurin Inhibitors |
MeSH PA | D003879 | Dermatologic Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D007155 | Immunologic Factors |
MeSH PA | D007166 | Immunosuppressive Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Atopic dermatitis | indication | 24079001 | DOID:3310 |
Intractable Eczema | indication | ||
Herpes zoster | contraindication | 4740000 | DOID:8536 |
Lymphadenopathy | contraindication | 30746006 | |
Immunosuppression | contraindication | 38013005 | |
Varicella | contraindication | 38907003 | DOID:8659 |
Verruca vulgaris | contraindication | 57019003 | DOID:11165 |
Herpes simplex | contraindication | 88594005 | DOID:8566 |
Viral infection of skin | contraindication | 128937004 | |
Eczema herpeticum | contraindication | 186535001 | DOID:9123 |
Infectious mononucleosis | contraindication | 271558008 | DOID:8568 |
Netherton's syndrome | contraindication | 312514006 | |
Impetiginized atopic dermatitis | contraindication | 402201001 | |
Pre-Malignant Skin Lesion | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 12.4 | acidic |
pKa2 | 13.57 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Peptidyl-prolyl cis-trans isomerase FKBP1A | Enzyme | INHIBITOR | Kd | 9 | WOMBAT-PK | CHEMBL | |||
Interleukin-5 | Cytokine | WOMBAT-PK | |||||||
Interferon gamma | Cytokine | WOMBAT-PK | |||||||
Interleukin-2 | Cytokine | WOMBAT-PK | |||||||
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform | Enzyme | WOMBAT-PK | |||||||
Peptidyl-prolyl cis-trans isomerase FKBP1A | Enzyme | INHIBITOR | IC50 | 8.22 | IUPHAR |
ID | Source |
---|---|
4021291 | VUID |
N0000148728 | NUI |
D05480 | KEGG_DRUG |
4021291 | VANDF |
C1099414 | UMLSCUI |
CHEBI:135888 | CHEBI |
CHEMBL1200686 | ChEMBL_ID |
DB00337 | DRUGBANK_ID |
C117268 | MESH_SUPPLEMENTAL_RECORD_UI |
6783 | IUPHAR_LIGAND_ID |
7632 | INN_ID |
7KYV510875 | UNII |
6509979 | PUBCHEM_CID |
306865 | RXNORM |
16235 | MMSL |
302773 | MMSL |
42597 | MMSL |
009525 | NDDF |
385580005 | SNOMEDCT_US |
385581009 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
ELIDEL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-5100 | CREAM | 10 mg | TOPICAL | NDA | 27 sections |
ELIDEL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-5101 | CREAM | 10 mg | TOPICAL | NDA | 27 sections |
ELIDEL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-5102 | CREAM | 10 mg | TOPICAL | NDA | 27 sections |
ELIDEL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-5103 | CREAM | 10 mg | TOPICAL | NDA | 27 sections |
pimecrolimus | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-2944 | CREAM | 10 mg | TOPICAL | ANDA | 25 sections |
Elidel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4878 | CREAM | 10 mg | TOPICAL | NDA | 25 sections |
Pimecrolimus | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68462-609 | CREAM | 10 mg | TOPICAL | ANDA | 25 sections |
Pimecrolimus | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68682-110 | CREAM | 10 mg | TOPICAL | NDA authorized generic | 27 sections |
Pimecrolimus | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68682-111 | CREAM | 10 mg | TOPICAL | NDA authorized generic | 27 sections |
Pimecrolimus | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68682-112 | CREAM | 10 mg | TOPICAL | NDA authorized generic | 27 sections |
pimecrolimus | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70518-2292 | CREAM | 10 mg | TOPICAL | ANDA | 25 sections |