sertraline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
serotonin reuptake inhibitors 2436 79617-96-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sertraline
  • sertraline hydrochloride
  • sertraline HCl
A selective serotonin uptake inhibitor that is used in the treatment of depression.
  • Molecular weight: 306.23
  • Formula: C17H17Cl2N
  • CLOGP: 5.35
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 1
  • TPSA: 12.03
  • ALOGS: -6.32
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 3.80 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.20 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 9.33 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 44 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
fu (Fraction unbound in plasma) 0.00 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.890 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 2.427 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 15.996 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 7.129 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 1.440 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 4.540 % High 1
herg hERG pIC50 5.808 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 2.280 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 7.638 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 1.790 % High 1
kinase-safety-class ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK7,MET,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,SIK2,TEK,TGFBR1 33
kinase-selectivity-class AKT3,AXL,EIF2AK3,EPHB4,GRK2,PDK4,PIK3CB 7
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 3.690 High 1
mh-clint Mouse hepatocyte intrinsic clearance 22.131 High 1
mppb Mouse plasma protein binding (% unbound) 1.300 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 13.002 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 2.820 % High 1
rh-clint Rat hepatocyte intrinsic clearance 22.233 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 6.060 % High 1
rppb Rat plasma protein binding (% unbound) 1.900 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 371.535 uM High 1

Approvals:

DateAgencyCompanyOrphan
Dec. 30, 1991 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intentional overdose 2178.04 9.34 2026 282900 91808 90251713
Intentional self-injury 2004.32 9.34 1212 283714 28122 90315399
Suicide attempt 1511 9.34 1502 283424 73897 90269624
Serotonin syndrome 1338.53 9.34 1042 283884 36845 90306676
Suicidal ideation 1171.79 9.34 1299 283627 72556 90270965
Drug abuse 1125.58 9.34 1341 283585 81006 90262515
Pemphigus 1003.27 9.34 4 284922 326860 90016661
Hand deformity 864.68 9.34 13 284913 296349 90047172
Drug interaction 784.77 9.34 2273 282653 274180 90069341
Systemic lupus erythematosus 784.44 9.34 105 284821 361791 89981730
Glossodynia 764.33 9.34 67 284859 321712 90021809
Toxicity to various agents 761.29 9.34 2308 282618 285538 90057983
Completed suicide 728.43 9.34 1487 283439 143571 90199950
Pericarditis 682.19 9.34 42 284884 270109 90073412
Agitation 649.72 9.34 922 284004 66176 90277345
Duodenal ulcer perforation 644.11 9.34 10 284916 221278 90122243
Helicobacter infection 626.16 9.34 19 284907 226831 90116690
Synovitis 623.87 9.34 137 284789 329615 90013906
Tremor 603.02 9.34 1424 283502 151749 90191772
Folliculitis 583.40 9.34 12 284914 204341 90139180
Contraindicated product administered 519.58 9.34 179 284747 319960 90023561
Infusion related reaction 502.56 9.34 348 284578 416432 89927089
Joint swelling 500.32 9.34 507 284419 502793 89840728
Anxiety 499.84 9.34 2113 282813 307659 90035862
Muscle injury 490.37 9.34 14 284912 176640 90166881
Somnolence 472.42 9.34 1589 283337 207495 90136026
Wound 472.01 9.34 181 284745 302799 90040722
Arthropathy 471.21 9.34 284 284642 365958 89977563
Akathisia 422.62 9.34 320 284606 10839 90332682
Swelling 422.19 9.34 417 284509 418641 89924880
Sopor 408.86 9.34 444 284482 24200 90319321
Alopecia 408.57 9.34 577 284349 494494 89849027
Irritable bowel syndrome 392.52 9.34 86 284840 207362 90136159
Impaired healing 390.29 9.34 125 284801 234074 90109447
Treatment failure 379.33 9.34 244 284682 303684 90039837
Sleep disorder due to general medical condition, insomnia type 373.61 9.34 6 284920 128688 90214833
Withdrawal syndrome 368.78 9.34 403 284523 22121 90321400
Hyponatraemia 366.75 9.34 1086 283840 132452 90211069
Hallucination, auditory 366.36 9.34 343 284583 15632 90327889
Psoriatic arthropathy 364.63 9.34 131 284795 228204 90115317
Stomatitis 364.57 9.34 205 284721 274493 90069028
Psychotic disorder 359.70 9.34 467 284459 30763 90312758
Hallucination 349.70 9.34 692 284234 65267 90278254
Abdominal discomfort 344.75 9.34 608 284318 476720 89866801
Blister 335.93 9.34 192 284734 254806 90088715
Abnormal behaviour 331.36 9.34 382 284544 22246 90321275
Overdose 315.76 9.34 1152 283774 156557 90186964
Type 2 diabetes mellitus 307.25 9.34 127 284799 203117 90140404
Dyskinesia 303.10 9.34 467 284459 36067 90307454
Hepatic enzyme increased 296.81 9.34 421 284505 360315 89983206
Rheumatoid arthritis 296.57 9.34 425 284501 362189 89981332
Lower respiratory tract infection 293.06 9.34 216 284710 250443 90093078
Mydriasis 291.11 9.34 294 284632 14718 90328803
Ill-defined disorder 290.22 9.34 109 284817 184782 90158739
C-reactive protein abnormal 285.48 9.34 33 284893 127396 90216125
Nasopharyngitis 281.84 9.34 532 284394 406572 89936949
Facet joint syndrome 279.83 9.34 6 284920 98383 90245138
Fibromyalgia 274.96 9.34 153 284773 206116 90137405
Therapeutic product effect decreased 272.71 9.34 282 284644 277289 90066232
Discomfort 271.47 9.34 277 284649 274058 90069463
Panic attack 271.06 9.34 373 284553 25992 90317529
Joint range of motion decreased 269.52 9.34 50 284876 135593 90207928
General physical health deterioration 268.49 9.34 439 284487 354676 89988845
Drug intolerance 267.95 9.34 635 284291 446956 89896565
Mania 267.30 9.34 273 284653 13851 90329670
Poisoning deliberate 263.01 9.34 291 284635 16195 90327326
Aggression 261.79 9.34 369 284557 26299 90317222
Dystonia 261.65 9.34 293 284633 16526 90326995
Neuroleptic malignant syndrome 259.22 9.34 277 284649 14819 90328702
Seizure 251.86 9.34 1049 283877 151580 90191941
Electrocardiogram QT prolonged 250.27 9.34 641 284285 71815 90271706
Liver injury 249.16 9.34 112 284814 170455 90173066
Lip dry 247.89 9.34 18 284908 100937 90242584
Rheumatoid factor positive 247.18 9.34 115 284811 171535 90171986
Bursitis 244.12 9.34 57 284869 131597 90211924
Paranoia 241.57 9.34 248 284678 12660 90330861
Hypomania 241.38 9.34 210 284716 8687 90334834
Parkinsonism 241.36 9.34 258 284668 13807 90329714
Restlessness 238.60 9.34 414 284512 35306 90308215
Extrapyramidal disorder 236.65 9.34 274 284652 16029 90327492
Wound infection 229.94 9.34 31 284895 106371 90237150
Disorientation 229.21 9.34 459 284467 43655 90299866
Tardive dyskinesia 224.75 9.34 221 284705 10709 90332812
Mobility decreased 218.92 9.34 280 284646 250454 90093067
Product use issue 218.83 9.34 442 284484 329477 90014044
Infection 218.77 9.34 511 284415 361583 89981938
Depressed mood 218.49 9.34 486 284440 49736 90293785
Schizophrenia 213.71 9.34 249 284677 14665 90328856
Sinusitis 212.25 9.34 478 284448 342610 90000911
Peripheral swelling 211.61 9.34 633 284293 412473 89931048
Grip strength decreased 209.80 9.34 23 284903 92553 90250968
Myoclonus 204.33 9.34 276 284650 18892 90324629
Depression 203.29 9.34 1628 283298 298973 90044548
Rash 203.15 9.34 1568 283358 794532 89548989
Peripheral venous disease 200.33 9.34 17 284909 83904 90259617
Hallucination, visual 199.76 9.34 301 284625 22791 90320730
Blood cholesterol increased 195.72 9.34 219 284707 207793 90135728
Gastrointestinal disorder 195.15 9.34 316 284610 256371 90087150
Bruxism 194.34 9.34 138 284788 4225 90339296
Drug withdrawal syndrome 193.27 9.34 334 284592 28389 90315132
Foetal exposure during pregnancy 191.61 9.34 420 284506 42555 90300966
Hallucinations, mixed 188.67 9.34 153 284773 5736 90337785
Arthralgia 185.88 9.34 1561 283365 776961 89566560
Hypercholesterolaemia 182.50 9.34 46 284880 100846 90242675
Feeling abnormal 182.15 9.34 1020 283906 166215 90177306
Psychomotor hyperactivity 180.40 9.34 212 284714 12601 90330920
Lung disorder 179.23 9.34 126 284800 149757 90193764
Pyrexia 178.81 9.34 1279 283647 659206 89684315
Autoimmune disorder 176.64 9.34 18 284908 76726 90266795
Crying 176.22 9.34 301 284625 25344 90318177
Loss of consciousness 175.70 9.34 889 284037 139349 90204172
Disturbance in attention 175.50 9.34 429 284497 46680 90296841
Hyperreflexia 174.32 9.34 154 284772 6503 90337018
Intentional product use issue 173.45 9.34 258 284668 216634 90126887
Self-injurious ideation 172.73 9.34 114 284812 3089 90340432
Musculoskeletal pain 171.51 9.34 171 284755 171080 90172441
Colitis microscopic 171.19 9.34 193 284733 10966 90332555
Anger 165.57 9.34 210 284716 13510 90330011
Tic 165.06 9.34 92 284834 1819 90341702
Hypersensitivity 164.64 9.34 802 284124 453875 89889646
Irritability 161.79 9.34 351 284575 35311 90308210
Abnormal dreams 161.39 9.34 188 284738 11069 90332452
Mental disorder 158.09 9.34 328 284598 31990 90311531
Delusion 157.86 9.34 206 284720 13634 90329887
Dislocation of vertebra 156.87 9.34 4 284922 55964 90287557
Adjustment disorder with depressed mood 155.60 9.34 5 284921 56748 90286773
Sciatica 155.34 9.34 62 284864 101320 90242201
Galactorrhoea 155.23 9.34 124 284802 4548 90338973
Inappropriate antidiuretic hormone secretion 150.23 9.34 241 284685 19264 90324257
Emotional distress 148.59 9.34 345 284581 36317 90307204
Osteoarthritis 144.05 9.34 246 284680 195484 90148037
Hyperhidrosis 143.55 9.34 824 284102 135481 90208040
Muscle rigidity 143.42 9.34 200 284726 14109 90329412
Hyperprolactinaemia 142.89 9.34 126 284800 5307 90338214
Swollen tongue 142.85 9.34 391 284535 45565 90297956
Nightmare 142.74 9.34 250 284676 21475 90322046
Poisoning 142.65 9.34 206 284720 15011 90328510
Bone erosion 140.79 9.34 6 284920 53015 90290506
Rhabdomyolysis 134.14 9.34 410 284516 50846 90292675
Hip arthroplasty 133.55 9.34 37 284889 76171 90267350
Inflammation 131.84 9.34 224 284702 178368 90165153
Thinking abnormal 131.29 9.34 173 284753 11559 90331962
Prescribed overdose 130.62 9.34 72 284854 97553 90245968
Homicidal ideation 130.48 9.34 77 284849 1703 90341818
Apathy 130.10 9.34 167 284759 10873 90332648
Cardiac arrest 128.46 9.34 661 284265 104274 90239247
Pain 126.63 9.34 2289 282637 994052 89349469
Knee arthroplasty 125.60 9.34 52 284874 83130 90260391
Musculoskeletal stiffness 125.51 9.34 493 284433 296039 90047482
Amenorrhoea 123.75 9.34 168 284758 11554 90331967
Complication of device insertion 123.19 9.34 158 284768 10278 90333243
Dizziness 122.72 9.34 2564 282362 586720 89756801
Vertigo 121.55 9.34 488 284438 69323 90274198
Mood swings 120.47 9.34 226 284700 20476 90323045
Suicidal behaviour 117.63 9.34 86 284840 2758 90340763
Treatment noncompliance 116.49 9.34 393 284533 51334 90292187
Product substitution issue 115.43 9.34 205 284721 17803 90325718
Lower limb fracture 114.76 9.34 62 284864 84951 90258570
Persistent genital arousal disorder 114.65 9.34 52 284874 648 90342873
Bradyphrenia 113.96 9.34 130 284796 7482 90336039
Gait inability 112.46 9.34 179 284747 146277 90197244
Oedema 111.97 9.34 294 284632 200001 90143520
Liver disorder 111.50 9.34 130 284796 121139 90222382
Coma 111.08 9.34 488 284438 72144 90271377
Infarction 110.99 9.34 85 284841 2928 90340593
Gestational diabetes 110.71 9.34 151 284775 10431 90333090
Fall 110.44 9.34 2127 282799 479683 89863838
Respiratory arrest 110.16 9.34 290 284636 33021 90310500
Febrile neutropenia 109.33 9.34 207 284719 158142 90185379
Depressed level of consciousness 109.02 9.34 486 284440 72298 90271223
Onychomadesis 107.93 9.34 10 284916 45988 90297533
Libido decreased 107.39 9.34 83 284843 2899 90340622
Nail disorder 106.68 9.34 27 284899 59040 90284481
C-reactive protein increased 106.23 9.34 260 284666 181129 90162392
Blepharospasm 104.77 9.34 23 284903 55422 90288099
X-ray abnormal 103.64 9.34 11 284915 45413 90298108
Live birth 103.45 9.34 60 284866 79047 90264474
Emotional disorder 103 9.34 176 284750 14821 90328700
Psychomotor retardation 102.52 9.34 99 284827 4690 90338831
Sedation 101.51 9.34 358 284568 47813 90295708
Dermatitis atopic 100.79 9.34 226 284700 23246 90320275
Urticaria 100.58 9.34 574 284352 312160 90031361
Tachycardia 100.01 9.34 842 284084 156831 90186690
Drug ineffective 99.59 9.34 3461 281465 1380837 88962684
Trismus 98.23 9.34 97 284829 4724 90338797
Swelling face 97.86 9.34 510 284416 80842 90262679
Syncope 97.57 9.34 733 284193 131930 90211591
Breast cancer stage II 97.27 9.34 3 284923 35331 90308190
Anorgasmia 96.04 9.34 46 284880 654 90342867
Myelosuppression 95.82 9.34 25 284901 53566 90289955
Salivary hypersecretion 95.51 9.34 130 284796 8962 90334559
Insomnia 94.51 9.34 1523 283403 331951 90011570
Homicide 93.91 9.34 36 284890 283 90343238
Dysarthria 93.37 9.34 379 284547 54103 90289418
Injury 92.76 9.34 314 284612 197035 90146486
Clonus 92.58 9.34 102 284824 5648 90337873
Loss of libido 92.07 9.34 56 284870 1311 90342210
Mental impairment 91.70 9.34 178 284748 16542 90326979
Off label use 91.32 9.34 2705 282221 1099547 89243974
Psychomotor skills impaired 90.70 9.34 74 284852 2798 90340723
Speech disorder 90.29 9.34 332 284594 45253 90298268
Taste disorder 87.38 9.34 42 284884 61504 90282017
Cholelithiasis 86.62 9.34 361 284565 52145 90291376
Generalised tonic-clonic seizure 85.60 9.34 273 284653 34630 90308891
Social avoidant behaviour 85.49 9.34 77 284849 3336 90340185
C-reactive protein 85.15 9.34 3 284923 31364 90312157
Nausea 84.49 9.34 4281 280645 1106035 89237486
Obsessive-compulsive disorder 83.31 9.34 86 284840 4418 90339103
Cardio-respiratory arrest 83.09 9.34 406 284520 62734 90280787
Major depression 82.83 9.34 128 284798 9907 90333614
Mental status changes 82.36 9.34 318 284608 44361 90299160
Drug dependence 81.84 9.34 240 284686 29087 90314434
Oromandibular dystonia 80.83 9.34 39 284887 564 90342957
Malignant neoplasm progression 80.74 9.34 132 284794 106738 90236783
Myopathy 80.43 9.34 149 284777 13369 90330152
Euphoric mood 80.34 9.34 92 284834 5317 90338204
Eosinophilic pneumonia acute 80.30 9.34 41 284885 674 90342847
Obesity 80.00 9.34 130 284796 105377 90238144
Catatonia 79.99 9.34 97 284829 5959 90337562
Muscle twitching 79.31 9.34 210 284716 23992 90319529
Bradykinesia 78.92 9.34 102 284824 6686 90336835
Reversible cerebral vasoconstriction syndrome 78.46 9.34 80 284846 4050 90339471
Respiratory disorder neonatal 78.32 9.34 51 284875 1350 90342171
Fear 78.14 9.34 166 284760 16456 90327065
Mood altered 78.05 9.34 169 284757 16975 90326546
Impulsive behaviour 77.70 9.34 55 284871 1675 90341846
Blood prolactin increased 77.51 9.34 75 284851 3562 90339959
Asthma-chronic obstructive pulmonary disease overlap syndrome 77.32 9.34 86 284840 4813 90338708
Jaundice cholestatic 77.21 9.34 124 284802 9919 90333602
Lupus-like syndrome 76.26 9.34 29 284897 48817 90294704
Lethargy 76.05 9.34 396 284530 62743 90280778
Flat affect 75.93 9.34 54 284872 1657 90341864
Affective disorder 75.25 9.34 107 284819 7686 90335835
Product complaint 74.38 9.34 144 284782 13356 90330165
Maculopathy 73.79 9.34 62 284864 2444 90341077
Onychomycosis 73.74 9.34 14 284912 37362 90306159
Formication 73.72 9.34 83 284843 4708 90338813
Activation syndrome 73.27 9.34 28 284898 218 90343303
Sensation of foreign body 72.98 9.34 95 284831 6271 90337250
Anhedonia 71.82 9.34 129 284797 11302 90332219
Balance disorder 71.71 9.34 537 284389 96543 90246978
Newborn persistent pulmonary hypertension 71.48 9.34 29 284897 269 90343252
Exostosis 71.34 9.34 39 284887 53095 90290426
Cardiac murmur 71.31 9.34 169 284757 18025 90325496
Pulmonary embolism 70.82 9.34 675 284251 130145 90213376
Total lung capacity increased 70.55 9.34 83 284843 4938 90338583
Intentional product misuse 69.82 9.34 502 284424 89102 90254419
Bipolar disorder 69.17 9.34 111 284815 8874 90334647
Lipid metabolism disorder 68.95 9.34 25 284901 165 90343356
Osteoporosis 68.55 9.34 124 284802 96407 90247114
Hypoaesthesia 68.53 9.34 644 284282 313566 90029955
Vision blurred 68.34 9.34 586 284340 109707 90233814
Finger deformity 67.79 9.34 11 284915 32886 90310635
Back injury 67.44 9.34 31 284895 46591 90296930
Drug screen false positive 67.05 9.34 40 284886 903 90342618
Thermal burn 67.00 9.34 94 284832 6668 90336853
Chronic obstructive pulmonary disease 66.69 9.34 429 284497 73400 90270121
Unresponsive to stimuli 65.96 9.34 266 284660 37855 90305666
Yawning 65.91 9.34 42 284884 1070 90342451
Restless legs syndrome 65.71 9.34 187 284739 22283 90321238
Urinary retention 65.01 9.34 263 284663 37481 90306040
Psychotic symptom 64.75 9.34 55 284871 2201 90341320
Altered state of consciousness 64.43 9.34 232 284694 31300 90312221
Negative thoughts 63.95 9.34 41 284885 1056 90342465
Cholecystitis chronic 63.16 9.34 112 284814 9714 90333807
Conversion disorder 63.00 9.34 53 284873 2093 90341428
Wheezing 62.76 9.34 464 284462 237616 90105905
Small for dates baby 62.58 9.34 78 284848 4929 90338592
Disorganised speech 62.56 9.34 50 284876 1835 90341686
Sexual dysfunction 61.91 9.34 76 284850 4728 90338793
Ductus arteriosus premature closure 61.65 9.34 29 284897 395 90343126
Breath sounds abnormal 61.48 9.34 144 284782 15242 90328279
Liver function test increased 61.16 9.34 108 284818 84747 90258774
Drug screen positive 61.10 9.34 67 284859 3690 90339831
Palpitations 60.47 9.34 677 284249 136051 90207470
Alcoholism 60.28 9.34 48 284878 1752 90341769
Therapy non-responder 59.89 9.34 224 284702 136480 90207041
Agitation neonatal 59.89 9.34 31 284895 525 90342996
Maternal exposure during pregnancy 59.86 9.34 785 284141 359278 89984243
Road traffic accident 59.34 9.34 159 284767 107467 90236054
Walking aid user 59.00 9.34 19 284907 35487 90308034
Pleurothotonus 58.94 9.34 42 284884 1293 90342228
Pregnancy with implant contraceptive 57.61 9.34 65 284861 3696 90339825
Heavy menstrual bleeding 57.27 9.34 168 284758 20362 90323159
Eye movement disorder 56.77 9.34 83 284843 6115 90337406
Urinary incontinence 56.36 9.34 251 284675 37315 90306206
Head titubation 56.23 9.34 40 284886 1228 90342293
Disease progression 56.12 9.34 277 284649 156338 90187183
Hypersomnia 56.11 9.34 172 284754 21359 90322162
Intrusive thoughts 55.56 9.34 27 284899 397 90343124
Drug withdrawal syndrome neonatal 55.50 9.34 51 284875 2268 90341253
Tension 55.32 9.34 63 284863 3619 90339902
Cytomegalovirus infection 54.58 9.34 9 284917 26593 90316928
Mitochondrial myopathy acquired 54.52 9.34 12 284914 3 90343518
Hypertension 53.56 9.34 1065 283861 456467 89887054
Product label confusion 53.52 9.34 5 284921 22845 90320676
Laryngitis 52.73 9.34 49 284877 50704 90292817
Upper gastrointestinal haemorrhage 52.11 9.34 175 284751 22801 90320720
Ear infection 51.94 9.34 87 284839 69688 90273833
Sinus tachycardia 51.78 9.34 202 284724 28311 90315210
Hepatic cirrhosis 51.74 9.34 74 284852 63179 90280342
Abnormal weight gain 51.31 9.34 52 284874 2613 90340908
Torticollis 51.25 9.34 51 284875 2507 90341014
Device placement issue 51.24 9.34 46 284880 1984 90341537
Device expulsion 51.02 9.34 259 284667 40627 90302894
Device dislocation 50.79 9.34 215 284711 31267 90312254
Night sweats 50.72 9.34 220 284706 128546 90214975
Foot deformity 50.58 9.34 68 284858 59583 90283938
Drug ineffective for unapproved indication 49.98 9.34 370 284556 66274 90277247
Therapeutic response unexpected 49.93 9.34 167 284759 21713 90321808
Tearfulness 49.69 9.34 68 284858 4712 90338809
Depersonalisation/derealisation disorder 49.34 9.34 41 284885 1591 90341930
Coeliac disease 48.84 9.34 41 284885 44569 90298952
Pain in extremity 48.81 9.34 1062 283864 449467 89894054
Joint dislocation 48.78 9.34 41 284885 44541 90298980
Nervousness 48.44 9.34 224 284702 33832 90309689
Sleep disorder 48.41 9.34 394 284532 197636 90145885
Hyperthermia 48.34 9.34 103 284823 10232 90333289
Immunodeficiency 48.25 9.34 39 284887 43195 90300326
Cerebral vasoconstriction 48.08 9.34 36 284890 1198 90342323
Adverse event 47.86 9.34 198 284728 117220 90226301
Emotional poverty 47.81 9.34 24 284902 380 90343141
Stress 47.58 9.34 427 284499 80968 90262553
Substance abuse 47.51 9.34 71 284855 5335 90338186
Movement disorder 47.45 9.34 199 284727 28820 90314701
Dysphagia 47.42 9.34 551 284375 111727 90231794
Foreign body in reproductive tract 47.34 9.34 35 284891 1142 90342379
Hypertonia 47.17 9.34 69 284857 5086 90338435
Cognitive disorder 46.85 9.34 376 284550 69031 90274490
Dyspepsia 46.75 9.34 398 284528 197762 90145759
Burning mouth syndrome 46.62 9.34 27 284899 576 90342945
Embedded device 46.54 9.34 62 284864 4186 90339335
Confusional state 46.36 9.34 1564 283362 384641 89958880
Vomiting 46.26 9.34 2970 281956 785323 89558198
Neutropenia 46.05 9.34 468 284458 224436 90119085
Stiff person syndrome 46.02 9.34 25 284901 469 90343052
Hypotonia 45.72 9.34 107 284819 11319 90332202
Complication of device removal 45.07 9.34 75 284851 6180 90337341
Adrenal insufficiency 44.69 9.34 19 284907 29902 90313619
Uterine perforation 44.61 9.34 83 284843 7471 90336050
Abdominal pain upper 43.36 9.34 760 284166 331914 90011607
Apraxia 43.30 9.34 44 284882 2218 90341303
Bipolar I disorder 42.62 9.34 42 284884 2040 90341481
Miosis 42.61 9.34 93 284833 9391 90334130
Rabbit syndrome 42.61 9.34 21 284905 319 90343202
Abulia 42.58 9.34 27 284899 682 90342839
Disturbance in sexual arousal 42.54 9.34 20 284906 272 90343249
Infusion site reaction 42.45 9.34 5 284921 19034 90324487
Metabolic syndrome 42.36 9.34 40 284886 1842 90341679
Presyncope 42.19 9.34 205 284721 31600 90311921
Nystagmus 42.17 9.34 79 284847 7148 90336373
Drowning 42.16 9.34 24 284902 495 90343026
Contusion 41.97 9.34 547 284379 250669 90092852
Joint stiffness 41.74 9.34 117 284809 77925 90265596
Depressive symptom 41.66 9.34 66 284860 5219 90338302
Bradycardia 41.65 9.34 425 284501 83422 90260099
Maternal exposure during breast feeding 41.41 9.34 72 284854 6148 90337373
Dissociation 41.19 9.34 75 284851 6640 90336881
Brain injury 40.76 9.34 81 284845 7657 90335864
Sarcoidosis 40.60 9.34 98 284828 10575 90332946
Ulcer haemorrhage 40.47 9.34 16 284910 26305 90317216
Conjunctival abrasion 40.40 9.34 11 284915 22 90343499
Social anxiety disorder 40.26 9.34 25 284901 608 90342913
Drug-induced liver injury 40.20 9.34 147 284779 90171 90253350
Multiple sclerosis relapse 40.14 9.34 292 284634 52013 90291508
Blood creatine phosphokinase increased 40.01 9.34 212 284714 33811 90309710
Schizoaffective disorder bipolar type 39.93 9.34 17 284909 180 90343341
Hyponatraemic syndrome 39.91 9.34 24 284902 550 90342971
Hyponatraemic seizure 39.86 9.34 23 284903 487 90343034
Atrial septal defect 39.60 9.34 83 284843 8151 90335370
Cycloplegia 39.59 9.34 9 284917 4 90343517
Psychiatric symptom 39.30 9.34 76 284850 7042 90336479
Mucosal inflammation 39.17 9.34 76 284850 57549 90285972
Pulmonary fibrosis 39.16 9.34 189 284737 107314 90236207
Caesarean section 39.08 9.34 138 284788 18439 90325082
Obsessive thoughts 38.64 9.34 24 284902 584 90342937
Menstruation irregular 38.47 9.34 81 284845 7979 90335542
Thrombocytopenia 38.45 9.34 445 284481 208280 90135241
Posture abnormal 38.40 9.34 45 284881 2666 90340855
Alcohol poisoning 38.08 9.34 38 284888 1874 90341647
Self-destructive behaviour 38.00 9.34 22 284904 469 90343052
Retroplacental haematoma 37.95 9.34 16 284910 165 90343356
Inappropriate affect 37.94 9.34 29 284897 996 90342525
Alcohol abuse 37.93 9.34 39 284887 1994 90341527
Perinatal depression 37.87 9.34 27 284899 832 90342689
Hypokinesia 37.78 9.34 122 284804 15575 90327946
Intermenstrual bleeding 37.59 9.34 87 284839 9136 90334385
Somnambulism 37.50 9.34 69 284857 6159 90337362
Flashback 37.45 9.34 19 284907 308 90343213
Maternal drugs affecting foetus 37.40 9.34 62 284864 5093 90338428
Borderline personality disorder 37.17 9.34 29 284897 1027 90342494
Impulse-control disorder 36.83 9.34 28 284898 954 90342567
Tinnitus 36.82 9.34 247 284679 42855 90300666
Food interaction 36.66 9.34 31 284895 1233 90342288
Antipsychotic drug level increased 36.65 9.34 52 284874 3727 90339794
Logorrhoea 36.54 9.34 44 284882 2683 90340838
Panic disorder 36.51 9.34 47 284879 3068 90340453
Dysphonia 36.38 9.34 330 284596 62754 90280767
Ataxia 36.22 9.34 132 284794 17910 90325611
Bundle branch block right 36.14 9.34 63 284863 5390 90338131
Eosinophilic myocarditis 36.02 9.34 24 284902 661 90342860
Tremor neonatal 35.90 9.34 15 284911 151 90343370
Depression suicidal 35.89 9.34 38 284888 2011 90341510
Therapeutic product effect incomplete 35.86 9.34 413 284513 193483 90150038
Head injury 35.77 9.34 193 284733 30995 90312526
Wrong patient 35.64 9.34 26 284900 831 90342690
Muscle tightness 35.62 9.34 108 284818 13331 90330190
Dysphemia 35.48 9.34 46 284880 3024 90340497
Headache 35.26 9.34 3159 281767 859587 89483934
Polydipsia 34.96 9.34 54 284872 4177 90339344
Incoherent 34.96 9.34 59 284867 4918 90338603
Hallucination, olfactory 34.71 9.34 18 284908 306 90343215
Phobia 34.39 9.34 19 284907 369 90343152
Victim of chemical submission 34.37 9.34 24 284902 715 90342806
Somatic symptom disorder of pregnancy 34.15 9.34 13 284913 100 90343421
Tachyphrenia 34.15 9.34 34 284892 1672 90341849
Petit mal epilepsy 33.80 9.34 58 284868 4900 90338621
Sensory disturbance 33.72 9.34 116 284810 15297 90328224
Product dose omission issue 33.66 9.34 1176 283750 290511 90053010
Neonatal respiratory distress syndrome 33.58 9.34 45 284881 3056 90340465
Renal impairment 33.57 9.34 194 284732 105227 90238294
Inborn error of lipid metabolism 33.36 9.34 7 284919 0 90343521
Long-chain acyl-coenzyme A dehydrogenase deficiency 33.36 9.34 7 284919 0 90343521
Nasal polyps 33.24 9.34 92 284834 10788 90332733
Foaming at mouth 32.91 9.34 30 284896 1320 90342201
Neonatal asphyxia 32.79 9.34 18 284908 345 90343176
Hypokalaemia 32.76 9.34 587 284339 130529 90212992
Postural orthostatic tachycardia syndrome 32.66 9.34 38 284888 2234 90341287
Cold sweat 32.60 9.34 108 284818 13973 90329548
Pancreatic fibrosis 32.26 9.34 12 284914 86 90343435
Confabulation 32.07 9.34 17 284909 303 90343218
Arthritis 31.87 9.34 354 284572 166961 90176560
Angioedema 31.82 9.34 328 284598 64548 90278973
Abortion missed 31.64 9.34 35 284891 1947 90341574
Increased appetite 31.61 9.34 95 284831 11670 90331851
Metabolic acidosis 31.48 9.34 290 284636 55386 90288135
Frequent bowel movements 31.46 9.34 84 284842 56851 90286670
Idiopathic intracranial hypertension 31.43 9.34 47 284879 3534 90339987
Mutism 31.32 9.34 33 284893 1736 90341785
Product tampering 31.27 9.34 19 284907 444 90343077
Septic shock 31.22 9.34 147 284779 84013 90259508
Drug dose titration not performed 31.15 9.34 23 284903 749 90342772
Diplopia 31.13 9.34 175 284751 28539 90314982
Cardiac failure 30.98 9.34 209 284717 109287 90234234
Sluggishness 30.94 9.34 62 284864 5897 90337624
Persistent depressive disorder 30.78 9.34 28 284898 1229 90342292
Post-traumatic stress disorder 30.73 9.34 67 284859 6761 90336760
Respiratory disorder 30.52 9.34 103 284823 64713 90278808
Adverse reaction 30.50 9.34 29 284897 29683 90313838
Alcohol use 30.35 9.34 32 284894 1685 90341836
Photophobia 30.33 9.34 140 284786 21129 90322392
Suspected suicide 30.32 9.34 82 284844 9486 90334035
Asphyxia 30.06 9.34 68 284858 7035 90336486
Bradycardia neonatal 30.05 9.34 26 284900 1067 90342454
Unintended pregnancy 29.99 9.34 71 284855 7566 90335955
Adverse drug reaction 29.99 9.34 229 284697 116472 90227049
Somatic symptom disorder 29.97 9.34 45 284881 3396 90340125
Rhinitis allergic 29.74 9.34 118 284808 16667 90326854
Poverty of thought content 29.39 9.34 8 284918 16 90343505
Disability 29.23 9.34 52 284874 40693 90302828
Hyperphagia 29.16 9.34 40 284886 2778 90340743
Hemivertebra 29.05 9.34 12 284914 117 90343404
Communication disorder 28.85 9.34 43 284883 3223 90340298
Adulterated product 28.77 9.34 17 284909 377 90343144
Merycism 28.77 9.34 16 284910 315 90343206
Generalised anxiety disorder 28.43 9.34 39 284887 2708 90340813
Physical assault 28.34 9.34 23 284903 863 90342658
Suppressed lactation 28.23 9.34 18 284908 459 90343062
Hypotonia neonatal 27.71 9.34 28 284898 1402 90342119
Hyperlactacidaemia 27.69 9.34 48 284878 4088 90339433
Neutrophil count decreased 27.69 9.34 123 284803 71409 90272112
Behaviour disorder 27.46 9.34 51 284875 4584 90338937
Congenital nystagmus 27.41 9.34 9 284917 42 90343479
Pustular psoriasis 27.37 9.34 12 284914 18544 90324977
Illness anxiety disorder 27.16 9.34 12 284914 140 90343381
Mitochondrial cytopathy 27.11 9.34 14 284912 236 90343285
Fluid retention 27.04 9.34 164 284762 87927 90255594
Pneumonia 27.01 9.34 1687 283239 636372 89707149
Parkinsonian gait 27.00 9.34 19 284907 573 90342948
Polyarthritis 26.85 9.34 12 284914 18338 90325183
Large for dates baby 26.85 9.34 18 284908 501 90343020
Phospholipidosis 26.64 9.34 14 284912 245 90343276
Feeling of despair 26.63 9.34 41 284885 3163 90340358
Chorea 26.58 9.34 33 284893 2077 90341444
Victim of crime 26.56 9.34 22 284904 850 90342671
Multiple sclerosis 26.52 9.34 164 284762 27676 90315845
Violence-related symptom 26.46 9.34 19 284907 592 90342929
Persistent foetal circulation 26.46 9.34 13 284913 196 90343325
Mitochondrial myopathy 26.39 9.34 14 284912 250 90343271
Dysphoria 26.13 9.34 59 284867 6095 90337426
Tubulointerstitial nephritis and uveitis syndrome 25.99 9.34 14 284912 258 90343263
Long QT syndrome 25.93 9.34 46 284880 3991 90339530
Heat stroke 25.87 9.34 22 284904 882 90342639
Sleep-related eating disorder 25.84 9.34 23 284903 981 90342540
Right ventricular hypertrophy 25.69 9.34 21 284905 796 90342725
Progressive bulbar palsy 25.55 9.34 9 284917 54 90343467
Central nervous system lupus 25.16 9.34 26 284900 1337 90342184
Myocardial fibrosis 25.14 9.34 22 284904 917 90342604
Factor XIII deficiency 25.11 9.34 10 284916 88 90343433
Trance 25.00 9.34 9 284917 58 90343463
Pelvic pain 24.86 9.34 105 284821 15252 90328269
Neuropathy peripheral 24.83 9.34 293 284633 136677 90206844
Water intoxication 24.73 9.34 18 284908 573 90342948
Accidental poisoning 24.72 9.34 22 284904 938 90342583
Spondylitis 24.62 9.34 7 284919 14171 90329350
Hereditary angioedema 24.58 9.34 75 284851 9290 90334231
Psychogenic seizure 24.55 9.34 31 284895 1985 90341536
Pseudodementia 24.53 9.34 10 284916 94 90343427
Abortion spontaneous 24.50 9.34 269 284657 53787 90289734
Neonatal respiratory distress 24.43 9.34 19 284907 670 90342851
Fatigue 24.41 9.34 3218 281708 1150805 89192716
Binge eating 24.36 9.34 18 284908 587 90342934
Dopamine transporter scintigraphy abnormal 24.35 9.34 10 284916 96 90343425
Decreased interest 24.27 9.34 47 284879 4360 90339161
Hallucination, gustatory 24.25 9.34 9 284917 64 90343457
Vaginal haemorrhage 24.23 9.34 175 284751 31096 90312425
Female genital tract fistula 24.15 9.34 13 284913 17855 90325666
Pre-eclampsia 24.04 9.34 83 284843 10965 90332556
Pulmonary valve incompetence 23.97 9.34 28 284898 1653 90341868
Pruritus 23.91 9.34 1426 283500 540099 89803422
Granuloma skin 23.91 9.34 81 284845 10599 90332922
Self esteem decreased 23.64 9.34 20 284906 796 90342725
Dissociative disorder 23.55 9.34 18 284908 618 90342903
Morning sickness 23.54 9.34 22 284904 1000 90342521
Vanishing twin syndrome 23.44 9.34 11 284915 149 90343372
Suspiciousness 23.41 9.34 15 284911 386 90343135
Neurosis 23.27 9.34 15 284911 390 90343131
Transient psychosis 23.14 9.34 8 284918 45 90343476
Herbal interaction 23.12 9.34 11 284915 154 90343367
Medication overuse headache 23.09 9.34 26 284900 1475 90342046
Urine sodium decreased 22.80 9.34 11 284915 159 90343362
Hyperventilation 22.68 9.34 59 284867 6669 90336852
Anticholinergic syndrome 22.65 9.34 35 284891 2708 90340813
Reflexes abnormal 22.59 9.34 19 284907 750 90342771
Polymenorrhoea 22.58 9.34 25 284901 1392 90342129
Metabolic myopathy 22.53 9.34 10 284916 118 90343403
Antisocial behaviour 22.47 9.34 17 284909 575 90342946
Substance use 22.37 9.34 23 284903 1176 90342345
Pancytopenia 22.29 9.34 256 284670 120007 90223514
Slow response to stimuli 22.23 9.34 22 284904 1074 90342447
Oral candidiasis 22.20 9.34 49 284877 35406 90308115
Gallbladder cholesterolosis 22.19 9.34 19 284907 769 90342752
Rash vesicular 22.13 9.34 15 284911 18182 90325339
Haematotoxicity 22.12 9.34 6 284920 12529 90330992
Underdose 22.06 9.34 91 284835 53926 90289595
Respiratory tract infection 22.02 9.34 103 284823 58975 90284546
Colitis ulcerative 21.92 9.34 106 284820 60160 90283361
Somatic delusion 21.91 9.34 17 284909 597 90342924
Screaming 21.89 9.34 41 284885 3709 90339812
Feeling drunk 21.77 9.34 47 284879 4711 90338810
Coma scale abnormal 21.77 9.34 52 284874 5574 90337947
Macular degeneration 21.76 9.34 55 284871 37915 90305606
Dehydration 21.68 9.34 781 284145 193666 90149855
Skin burning sensation 21.57 9.34 120 284806 19491 90324030
Collagen-vascular disease 21.50 9.34 9 284917 91 90343430
Catastrophic reaction 21.44 9.34 7 284919 32 90343489
Suicide threat 21.44 9.34 7 284919 32 90343489
Amniotic fluid volume increased 21.32 9.34 11 284915 185 90343336
Haemophagocytic lymphohistiocytosis 21.26 9.34 11 284915 15448 90328073
Biliary dyskinesia 21.24 9.34 33 284893 2566 90340955
Attention deficit hyperactivity disorder 21.09 9.34 43 284883 4141 90339380
Neonatal behavioural syndrome 21.08 9.34 9 284917 96 90343425
Bronchopulmonary aspergillosis 20.99 9.34 5 284921 11393 90332128
Asthma 20.96 9.34 590 284336 241570 90101951
Congenital brain damage 20.90 9.34 5 284921 4 90343517
Delusional disorder, persecutory type 20.87 9.34 13 284913 318 90343203
Gallbladder injury 20.74 9.34 23 284903 1283 90342238
Muscle contracture 20.60 9.34 27 284899 1794 90341727
Vaginal flatulence 20.58 9.34 7 284919 12631 90330890
Action tremor 20.55 9.34 13 284913 327 90343194
Energy increased 20.53 9.34 36 284890 3094 90340427
Central vision loss 20.53 9.34 8 284918 66 90343455
Hypercapnic coma 20.51 9.34 12 284914 261 90343260
Thrombotic microangiopathy 20.49 9.34 12 284914 15731 90327790
Orthostatic hypertension 20.45 9.34 16 284910 569 90342952
Nervous system disorder 20.44 9.34 127 284799 21466 90322055
Electrocardiogram T wave abnormal 20.41 9.34 33 284893 2655 90340866
Femur-fibula-ulna complex 20.38 9.34 5 284921 5 90343516
Hyperammonaemic encephalopathy 20.31 9.34 33 284893 2666 90340855
Aphasia 20.31 9.34 215 284711 42597 90300924
Judgement impaired 20.29 9.34 19 284907 866 90342655
Environmental exposure 20.22 9.34 9 284917 107 90343414
Congenital skin dimples 20.00 9.34 9 284917 110 90343411
Tachypnoea 19.96 9.34 125 284801 21184 90322337
Micturition urgency 19.92 9.34 79 284847 11154 90332367
Creatinine renal clearance decreased 19.92 9.34 18 284908 18881 90324640
Burning sensation 19.92 9.34 295 284631 63157 90280364
Gambling disorder 19.80 9.34 22 284904 1230 90342291
Cytokine release syndrome 19.79 9.34 36 284890 27937 90315584
Product taste abnormal 19.77 9.34 31 284895 2429 90341092
Exposure via breast milk 19.77 9.34 30 284896 2285 90341236
Disease recurrence 19.73 9.34 193 284733 37460 90306061
Enthesopathy 19.70 9.34 3 284923 9401 90334120
Breast discharge 19.70 9.34 22 284904 1237 90342284
Hypochloraemia 19.65 9.34 32 284894 2590 90340931
Eosinophilic pneumonia 19.65 9.34 33 284893 2740 90340781
Delusional disorder, unspecified type 19.62 9.34 14 284912 432 90343089
Oculogyric crisis 19.60 9.34 31 284895 2448 90341073
Snoring 19.42 9.34 47 284879 5079 90338442
Tubulointerstitial nephritis 19.42 9.34 31 284895 25312 90318209
Pleural effusion 19.37 9.34 242 284684 111749 90231772
Alcohol intolerance 19.37 9.34 9 284917 119 90343402
Target skin lesion 19.37 9.34 9 284917 119 90343402
Hyponatraemic encephalopathy 19.25 9.34 12 284914 294 90343227
Hemianopia 19.24 9.34 28 284898 2054 90341467
Haematemesis 19.23 9.34 176 284750 33550 90309971
CYP3A4 polymorphism 19.19 9.34 8 284918 80 90343441
Negative symptoms in schizophrenia 19.17 9.34 9 284917 122 90343399
Product administration interrupted 19.14 9.34 84 284842 12408 90331113
Breast pain 19.07 9.34 74 284852 10344 90333177
Intracranial meningioma malignant 19.06 9.34 4 284922 0 90343521
Cholestasis 18.99 9.34 186 284740 36113 90307408
Delusion of reference 18.98 9.34 9 284917 125 90343396
Dopamine dysregulation syndrome 18.98 9.34 10 284916 176 90343345
Flight of ideas 18.96 9.34 14 284912 456 90343065
Tongue discolouration 18.93 9.34 37 284889 3456 90340065
Diaphragmatic rupture 18.89 9.34 11 284915 237 90343284
Pulmonary valve stenosis congenital 18.88 9.34 10 284916 178 90343343
Morbid thoughts 18.86 9.34 17 284909 737 90342784
Cholestasis of pregnancy 18.81 9.34 24 284902 1553 90341968
Claustrophobia 18.75 9.34 22 284904 1305 90342216
Haematoma muscle 18.75 9.34 26 284900 1824 90341697
Upper respiratory tract infection 18.72 9.34 287 284639 128031 90215490
Panic reaction 18.68 9.34 44 284882 4673 90338848
Blood parathyroid hormone decreased 18.61 9.34 82 284844 12134 90331387
Urine chloride decreased 18.60 9.34 8 284918 87 90343434
Blood pressure diastolic abnormal 18.60 9.34 21 284905 19860 90323661
Abnormal uterine bleeding 18.51 9.34 27 284899 1985 90341536
Nuchal rigidity 18.48 9.34 17 284909 757 90342764
Tongue spasm 18.44 9.34 8 284918 89 90343432
Derealisation 18.35 9.34 23 284903 1462 90342059
Impaired reasoning 18.30 9.34 9 284917 136 90343385
Enuresis 18.30 9.34 36 284890 3378 90340143
Prescription drug used without a prescription 18.27 9.34 35 284891 3220 90340301
Butterfly rash 18.21 9.34 28 284898 2157 90341364
Lack of spontaneous speech 18.20 9.34 10 284916 192 90343329
Complication associated with device 18.17 9.34 114 284812 19335 90324186
Neurologic neglect syndrome 18.13 9.34 3 284923 8844 90334677
Neurological symptom 18.12 9.34 55 284871 6792 90336729
Faeces discoloured 18.10 9.34 122 284804 21198 90322323
Syndactyly 18.10 9.34 15 284911 580 90342941
Libido disorder 18.05 9.34 7 284919 57 90343464
Autonomic nervous system imbalance 18.04 9.34 36 284890 3414 90340107
Oral discomfort 18.01 9.34 73 284853 10410 90333111
Microcephaly 18.01 9.34 22 284904 1362 90342159
Pneumocystis jirovecii pneumonia 17.96 9.34 25 284901 21591 90321930
Incorrect route of product administration 17.86 9.34 90 284836 50536 90292985
Menopause 17.78 9.34 35 284891 3286 90340235
Subdural haematoma 17.75 9.34 101 284825 16544 90326977
Pulmonary toxicity 17.74 9.34 7 284919 11524 90331997
Gastrointestinal toxicity 17.74 9.34 4 284922 9463 90334058
Female orgasmic disorder 17.74 9.34 7 284919 60 90343461
Tenosynovitis 17.73 9.34 12 284914 14555 90328966
Compulsions 17.71 9.34 10 284916 203 90343318
Hypertonia neonatal 17.70 9.34 11 284915 268 90343253
Partner stress 17.56 9.34 13 284913 425 90343096
Food craving 17.52 9.34 26 284900 1941 90341580
Sinus bradycardia 17.51 9.34 102 284824 16850 90326671
Soliloquy 17.50 9.34 12 284914 347 90343174
Spleen congestion 17.48 9.34 8 284918 102 90343419
Hepatic cytolysis 17.46 9.34 161 284765 30755 90312766
Aplastic anaemia 17.44 9.34 10 284916 13259 90330262
Persecutory delusion 17.41 9.34 34 284892 3174 90340347
Pulmonary infarction 17.36 9.34 32 284894 2860 90340661
Purple glove syndrome 17.32 9.34 10 284916 212 90343309
Chest discomfort 17.24 9.34 563 284363 137802 90205719
Deep vein thrombosis 17.17 9.34 393 284533 91227 90252294
Teratoma benign 17.15 9.34 7 284919 66 90343455
Electrocardiogram abnormal 17.13 9.34 71 284855 10227 90333294
Dyspnoea 17.10 9.34 2469 282457 878486 89465035
Infantile vomiting 17.10 9.34 9 284917 158 90343363
Dry mouth 17.08 9.34 444 284482 183615 90159906
Dental caries 16.98 9.34 76 284850 11321 90332200
Hepatocellular injury 16.96 9.34 152 284774 28806 90314715
Dyspareunia 16.94 9.34 31 284895 2755 90340766
Hypersensitivity pneumonitis 16.93 9.34 38 284888 3910 90339611
Neoplasm progression 16.91 9.34 77 284849 44409 90299112
Platelet count decreased 16.85 9.34 316 284610 136653 90206868
Heat exhaustion 16.83 9.34 10 284916 224 90343297
Ideas of reference 16.81 9.34 8 284918 112 90343409
Breast enlargement 16.80 9.34 24 284902 1731 90341790
Thirst 16.80 9.34 98 284828 16197 90327324
Attention-seeking behaviour 16.79 9.34 7 284919 70 90343451
Atrioventricular dissociation 16.79 9.34 10 284916 225 90343296
Blood pressure systolic abnormal 16.72 9.34 22 284904 19456 90324065
Genital hypoaesthesia 16.70 9.34 5 284921 16 90343505
Blood test abnormal 16.65 9.34 25 284901 20927 90322594
Exposure via ingestion 16.63 9.34 30 284896 2637 90340884
Brugada syndrome 16.63 9.34 13 284913 462 90343059
Visceral congestion 16.60 9.34 12 284914 378 90343143
Leukopenia 16.54 9.34 220 284706 100490 90243031
Product prescribing error 16.53 9.34 156 284770 29989 90313532
Anaphylactic shock 16.46 9.34 48 284878 31569 90311952
Extrasystoles 16.46 9.34 47 284879 5610 90337911
Threatened labour 16.34 9.34 17 284909 881 90342640
Anal incontinence 16.34 9.34 97 284829 16133 90327388
Pharyngeal oedema 16.32 9.34 86 284840 13685 90329836
Dependence 16.29 9.34 26 284900 2069 90341452
Asocial behaviour 16.25 9.34 5 284921 18 90343503
Postpartum haemorrhage 16.25 9.34 28 284898 2373 90341148
Periarthritis 16.25 9.34 32 284894 3005 90340516
Device breakage 16.16 9.34 87 284839 13957 90329564
Delirium 16.09 9.34 436 284490 103923 90239598
Gestational hypertension 16.07 9.34 32 284894 3030 90340491
Muscle spasticity 16.04 9.34 57 284869 35265 90308256
Drug resistance 16.02 9.34 46 284880 30403 90313118
Incontinence 15.99 9.34 84 284842 13351 90330170
Cerebellar hypoplasia 15.97 9.34 8 284918 126 90343395
Accommodation disorder 15.96 9.34 12 284914 402 90343119
Acute psychosis 15.95 9.34 32 284894 3046 90340475
Abdominal pain 15.94 9.34 1448 283478 394273 89949248
Deprescribing error 15.89 9.34 6 284920 45 90343476
Pseudomonas infection 15.86 9.34 14 284912 14851 90328670
Belligerence 15.86 9.34 8 284918 128 90343393
Muscle contractions involuntary 15.85 9.34 31 284895 2897 90340624
Embolic cerebellar infarction 15.84 9.34 5 284921 20 90343501
Phalangeal hypoplasia 15.84 9.34 5 284921 20 90343501
Fear of weight gain 15.84 9.34 5 284921 20 90343501
Lipidosis 15.78 9.34 6 284920 46 90343475
Trichotillomania 15.75 9.34 8 284918 130 90343391
Urinary hesitation 15.73 9.34 28 284898 2435 90341086
Tuberculosis 15.73 9.34 10 284916 12539 90330982
Postmortem blood drug level increased 15.72 9.34 15 284911 700 90342821
Erythromelalgia 15.68 9.34 11 284915 330 90343191
Chronic sinusitis 15.65 9.34 32 284894 23770 90319751
Neonatal seizure 15.61 9.34 14 284912 603 90342918
Panniculitis 15.59 9.34 88 284838 14370 90329151
Proctitis 15.54 9.34 15 284911 15244 90328277
Marital problem 15.46 9.34 9 284917 194 90343327
Product quality issue 15.43 9.34 167 284759 79158 90264363
General symptom 15.43 9.34 14 284912 14654 90328867
Boredom 15.42 9.34 4 284922 6 90343515
Hepatic function abnormal 15.37 9.34 84 284842 46204 90297317
Accidental overdose 15.34 9.34 146 284780 28127 90315394
Mucosal dryness 15.32 9.34 32 284894 3135 90340386
Cardiomegaly 15.30 9.34 107 284819 18818 90324703
Dysgraphia 15.30 9.34 35 284891 3648 90339873
Skin warm 15.23 9.34 56 284870 7631 90335890
Cataract 15.16 9.34 149 284777 71943 90271578
Subchorionic haemorrhage 15.13 9.34 9 284917 202 90343319
Vasodilation procedure 15.11 9.34 5 284921 24 90343497
Facial paralysis 15.10 9.34 92 284834 15442 90328079
Gaze palsy 15.07 9.34 22 284904 1619 90341902
Reduced facial expression 15.01 9.34 28 284898 2525 90340996
Lip blister 15.01 9.34 30 284896 2848 90340673
Palmar-plantar erythrodysaesthesia syndrome 14.99 9.34 42 284884 27981 90315540
Prescribed underdose 14.97 9.34 157 284769 74862 90268659
Gallbladder disorder 14.87 9.34 110 284816 19693 90323828
Visual field defect 14.87 9.34 53 284873 7113 90336408
Rectal cancer metastatic 14.86 9.34 10 284916 280 90343241
Ectopic pregnancy 14.81 9.34 32 284894 3209 90340312
Seizure like phenomena 14.79 9.34 20 284906 1370 90342151
Neonatal tachypnoea 14.78 9.34 8 284918 149 90343372
Laryngomalacia 14.78 9.34 8 284918 149 90343372
Distractibility 14.77 9.34 13 284913 546 90342975
Dysmenorrhoea 14.76 9.34 40 284886 4632 90338889
Endoscopic retrograde cholangiopancreatography 14.75 9.34 9 284917 212 90343309
Motor neurone disease 14.75 9.34 9 284917 212 90343309
Serum serotonin increased 14.71 9.34 9 284917 213 90343308
Mitochondrial encephalomyopathy 14.71 9.34 7 284919 98 90343423
Wrong technique in product usage process 14.68 9.34 311 284615 71260 90272261
Starvation ketoacidosis 14.60 9.34 9 284917 216 90343305
Coital bleeding 14.57 9.34 14 284912 659 90342862
Breast cancer stage I 14.55 9.34 6 284920 9618 90333903
Heart rate increased 14.48 9.34 461 284465 112441 90231080
Brain oedema 14.47 9.34 99 284827 17286 90326235
Blindness transient 14.46 9.34 39 284887 4504 90339017
Appetite disorder 14.44 9.34 62 284864 9071 90334450
Opisthotonus 14.44 9.34 11 284915 376 90343145
Infantile apnoea 14.43 9.34 19 284907 1268 90342253
Maternal condition affecting foetus 14.38 9.34 9 284917 222 90343299
Premature baby 14.36 9.34 131 284795 24946 90318575
Temporomandibular joint syndrome 14.34 9.34 36 284890 3981 90339540
Product odour abnormal 14.33 9.34 21 284905 1550 90341971
Leukaemoid reaction 14.31 9.34 9 284917 224 90343297
Postictal headache 14.30 9.34 3 284923 0 90343521
Anaplastic large cell lymphoma T- and null-cell types stage IV 14.30 9.34 3 284923 0 90343521
Large intestine polyp 14.29 9.34 63 284863 9323 90334198
Grandiosity 14.29 9.34 10 284916 299 90343222
Wound complication 14.28 9.34 40 284886 4723 90338798
Postural tremor 14.26 9.34 12 284914 474 90343047
Gastritis 14.25 9.34 197 284729 41556 90301965
Eosinophilic cellulitis 14.17 9.34 9 284917 228 90343293
Feelings of worthlessness 14.16 9.34 11 284915 387 90343134
Gait deviation 14.14 9.34 6 284920 63 90343458
Akinesia 14.13 9.34 22 284904 1714 90341807
Pathogen resistance 14.10 9.34 4 284922 8111 90335410
Skin neoplasm excision 14.03 9.34 22 284904 1724 90341797
Intentional underdose 14.01 9.34 24 284902 2025 90341496
Delusional perception 14.00 9.34 9 284917 233 90343288
Joint hyperextension 13.99 9.34 11 284915 394 90343127
Respiratory tract congestion 13.99 9.34 42 284884 27368 90316153
Protein urine present 13.94 9.34 51 284875 6933 90336588
Alkalosis hypochloraemic 13.93 9.34 9 284917 235 90343286
Gangrene 13.89 9.34 12 284914 12864 90330657
Dependent personality disorder 13.89 9.34 6 284920 66 90343455
Drug-device interaction 13.88 9.34 7 284919 112 90343409
Chapped lips 13.86 9.34 29 284897 2844 90340677
Frontotemporal dementia 13.85 9.34 11 284915 400 90343121
Gynaecomastia 13.83 9.34 9 284917 238 90343283
Metastases to bone 13.81 9.34 38 284888 25467 90318054
Inadequate analgesia 13.79 9.34 31 284895 3193 90340328
Hypophagia 13.70 9.34 173 284753 35764 90307757
Body mass index increased 13.64 9.34 20 284906 1477 90342044
Gross motor delay 13.63 9.34 8 284918 175 90343346
Transplant rejection 13.63 9.34 12 284914 12746 90330775
Neonatal hypoxia 13.60 9.34 14 284912 717 90342804
Microencephaly 13.55 9.34 4 284922 12 90343509
Ventricular compliance decreased 13.54 9.34 5 284921 35 90343486
Blood creatine phosphokinase 13.51 9.34 8 284918 178 90343343
Blood calcium decreased 13.51 9.34 49 284877 30133 90313388
Menopausal disorder 13.50 9.34 6 284920 71 90343450
Coordination abnormal 13.50 9.34 114 284812 21242 90322279
Nephropathy toxic 13.48 9.34 12 284914 12676 90330845
Uterine contractions during pregnancy 13.46 9.34 13 284913 616 90342905
Hostility 13.45 9.34 25 284901 2248 90341273
Cluster headache 13.45 9.34 15 284911 842 90342679
Device material issue 13.41 9.34 11 284915 419 90343102
Blood alkaline phosphatase increased 13.36 9.34 219 284707 47860 90295661
Herpes zoster 13.36 9.34 213 284713 94431 90249090
Red blood cell sedimentation rate increased 13.36 9.34 181 284745 82414 90261107
Implant site pain 13.35 9.34 27 284899 2585 90340936
Karyotype analysis abnormal 13.32 9.34 4 284922 13 90343508
Febrile bone marrow aplasia 13.29 9.34 7 284919 9731 90333790
Paralysis recurrent laryngeal nerve 13.28 9.34 6 284920 74 90343447
Congenital hydronephrosis 13.28 9.34 11 284915 425 90343096
Implant site irritation 13.28 9.34 8 284918 184 90343337
Skin necrosis 13.24 9.34 95 284831 16846 90326675
Asterixis 13.22 9.34 21 284905 1664 90341857
Dyspraxia 13.22 9.34 9 284917 257 90343264
Premature rupture of membranes 13.20 9.34 43 284883 5515 90338006
Tricuspid valve incompetence 13.18 9.34 94 284832 16637 90326884
Parakeratosis 13.17 9.34 10 284916 340 90343181
Dementia Alzheimer's type 13.17 9.34 16 284910 985 90342536
Ophthalmic vein thrombosis 13.15 9.34 10 284916 341 90343180
Congenital hypoplasia of depressor angularis oris muscle 13.14 9.34 6 284920 76 90343445
Neutropenic sepsis 13.13 9.34 23 284903 18107 90325414
Melaena 13.05 9.34 167 284759 34630 90308891
Lactate pyruvate ratio increased 12.94 9.34 6 284920 79 90343442
Athetosis 12.94 9.34 6 284920 79 90343442
Abnormal loss of weight 12.93 9.34 49 284877 6774 90336747
Flank pain 12.89 9.34 104 284822 19118 90324403
Lactation disorder 12.89 9.34 11 284915 443 90343078
Alice in wonderland syndrome 12.86 9.34 5 284921 41 90343480
Feeling guilty 12.80 9.34 13 284913 655 90342866
Mycobacterium ulcerans infection 12.76 9.34 5 284921 42 90343479
CSF glucose decreased 12.74 9.34 6 284920 82 90343439
Cytomegalovirus viraemia 12.71 9.34 4 284922 7582 90335939
Lip swelling 12.71 9.34 181 284745 38429 90305092
Negativism 12.70 9.34 11 284915 452 90343069
Congenital aqueductal stenosis 12.67 9.34 4 284922 16 90343505
Granulocytopenia neonatal 12.67 9.34 4 284922 16 90343505
Persistent postural-perceptual dizziness 12.67 9.34 4 284922 16 90343505
Coronary artery insufficiency 12.67 9.34 6 284920 83 90343438
Psychotic behaviour 12.67 9.34 13 284913 663 90342858
Oropharyngeal blistering 12.64 9.34 16 284910 1027 90342494
Fluid intake reduced 12.58 9.34 35 284891 4117 90339404
Maternal exposure timing unspecified 12.55 9.34 33 284893 22450 90321071
Mental fatigue 12.54 9.34 13 284913 671 90342850
Peritonitis 12.53 9.34 27 284899 19678 90323843
Impaired self-care 12.53 9.34 21 284905 1741 90341780
Essential hypertension 12.51 9.34 46 284880 6269 90337252
Narcotic bowel syndrome 12.49 9.34 7 284919 140 90343381
Bronchiectasis 12.46 9.34 116 284810 22214 90321307
Sepsis 12.45 9.34 451 284475 179363 90164158
Congenital tricuspid valve incompetence 12.44 9.34 7 284919 141 90343380
Blood urine present 12.43 9.34 95 284831 17183 90326338
Analgesic drug level increased 12.41 9.34 28 284898 2891 90340630
Pancreatitis acute 12.41 9.34 155 284771 31960 90311561
Hot flush 12.36 9.34 259 284667 59229 90284292
Renal dysplasia 12.35 9.34 10 284916 374 90343147
Economic problem 12.34 9.34 30 284896 3251 90340270
Disinhibition 12.34 9.34 16 284910 1052 90342469
Obsessive-compulsive personality disorder 12.30 9.34 4 284922 18 90343503
Brain death 12.28 9.34 34 284892 3987 90339534
Neonatal disorder 12.23 9.34 12 284914 580 90342941
Eye injury 12.22 9.34 10 284916 11010 90332511
Pulmonary artery stenosis 12.17 9.34 9 284917 294 90343227
Glucose tolerance impaired in pregnancy 12.13 9.34 4 284922 19 90343502
Labelled drug-drug interaction medication error 12.12 9.34 83 284843 14499 90329022
Ventricular septal defect 12.10 9.34 41 284885 5366 90338155
Helplessness 12.06 9.34 9 284917 298 90343223
Vanishing bile duct syndrome 12.03 9.34 18 284908 1354 90342167
Arnold-Chiari malformation 12.02 9.34 13 284913 705 90342816
Staphylococcal scalded skin syndrome 12.02 9.34 7 284919 151 90343370
Mite allergy 11.99 9.34 14 284912 826 90342695
Retching 11.96 9.34 102 284824 19057 90324464
Drug use disorder 11.96 9.34 55 284871 8288 90335233
Pelvic inflammatory disease 11.94 9.34 21 284905 1809 90341712
Idiosyncratic drug reaction 11.93 9.34 15 284911 956 90342565
Periodic limb movement disorder 11.92 9.34 12 284914 598 90342923
Bladder discomfort 11.91 9.34 14 284912 832 90342689
Polymenorrhagia 11.91 9.34 5 284921 51 90343470
Rash erythematous 11.90 9.34 139 284787 64965 90278556
Hypoosmolar state 11.86 9.34 8 284918 225 90343296
White blood cell count decreased 11.83 9.34 418 284508 166691 90176830
Shared psychotic disorder 11.80 9.34 4 284922 21 90343500
Torsade de pointes 11.79 9.34 85 284841 15097 90328424
Dizziness postural 11.75 9.34 58 284868 8995 90334526
Right ventricular dilatation 11.75 9.34 20 284906 1679 90341842
Blood citric acid increased 11.74 9.34 5 284921 53 90343468
Polyhydramnios 11.73 9.34 25 284901 2483 90341038
Orgasm abnormal 11.73 9.34 6 284920 99 90343422
Hypersexuality 11.66 9.34 12 284914 614 90342907
Drug abuser 11.66 9.34 26 284900 2664 90340857
Antidepressant discontinuation syndrome 11.66 9.34 7 284919 160 90343361
Phalangeal agenesis 11.66 9.34 5 284921 54 90343467
Amnestic disorder 11.65 9.34 10 284916 406 90343115
Prothrombin time ratio decreased 11.64 9.34 15 284911 980 90342541
Meconium in amniotic fluid 11.63 9.34 9 284917 315 90343206
Malaise 11.61 9.34 1640 283286 584346 89759175
Anaemia 11.59 9.34 953 283973 351849 89991672
Heart rate 11.58 9.34 8 284918 234 90343287
May-Thurner syndrome 11.58 9.34 5 284921 55 90343466
Immature respiratory system 11.58 9.34 5 284921 55 90343466
Menstrual disorder 11.56 9.34 44 284882 6094 90337427
Bone marrow failure 11.53 9.34 57 284869 32164 90311357
Sinoatrial block 11.52 9.34 15 284911 990 90342531
Hunger 11.51 9.34 46 284880 6517 90337004
Multiple-drug resistance 11.51 9.34 5 284921 7771 90335750
Crime 11.50 9.34 4 284922 23 90343498
Coprolalia 11.50 9.34 4 284922 23 90343498
Accidental death 11.47 9.34 22 284904 2026 90341495
Device kink 11.44 9.34 23 284903 2192 90341329
Chemical submission 11.43 9.34 11 284915 519 90343002
Drug clearance decreased 11.39 9.34 21 284905 1877 90341644
Impaired driving ability 11.38 9.34 39 284887 5134 90338387
Migraine 11.34 9.34 486 284440 189906 90153615
Spontaneous haematoma 11.33 9.34 16 284910 1142 90342379
Traumatic haemothorax 11.32 9.34 8 284918 243 90343278
Alcohol interaction 11.28 9.34 20 284906 1734 90341787
Breast discomfort 11.26 9.34 12 284914 640 90342881
Sleep paralysis 11.24 9.34 14 284912 884 90342637
Cardio-respiratory distress 11.14 9.34 7 284919 174 90343347
Implant site rash 11.14 9.34 7 284919 174 90343347
Poor feeding infant 11.12 9.34 11 284915 537 90342984
Cogwheel rigidity 11.07 9.34 22 284904 2080 90341441
Hearing aid user 11.05 9.34 5 284921 62 90343459
Carnitine deficiency 11.03 9.34 7 284919 177 90343344
Fear of death 11.02 9.34 16 284910 1171 90342350
Foreign body in urogenital tract 11.02 9.34 3 284923 6 90343515
Pityriasis 11.02 9.34 3 284923 6 90343515
Decreased activity 11.01 9.34 53 284873 8139 90335382
Intention tremor 10.99 9.34 10 284916 439 90343082
Neuroendocrine carcinoma 10.97 9.34 9 284917 343 90343178
Indifference 10.96 9.34 7 284919 179 90343342
Serum serotonin decreased 10.96 9.34 4 284922 27 90343494
Inhibitory drug interaction 10.93 9.34 28 284898 3135 90340386
Arrested labour 10.93 9.34 8 284918 257 90343264
Stupor 10.91 9.34 40 284886 5442 90338079
Myositis 10.91 9.34 39 284887 24089 90319432
Stereotypy 10.86 9.34 10 284916 446 90343075
Injection site reaction 10.84 9.34 214 284712 91866 90251655
Cushingoid 10.84 9.34 10 284916 10385 90333136
Bone density decreased 10.84 9.34 24 284902 17321 90326200
Pneumonia aspiration 10.83 9.34 185 284741 40755 90302766
Coronary artery dilatation 10.83 9.34 4 284922 28 90343493
Cerebellar haemorrhage 10.83 9.34 19 284907 1634 90341887
Retroperitoneal haematoma 10.81 9.34 29 284897 3339 90340182
Monocyte percentage decreased 10.77 9.34 8 284918 263 90343258
Staphylococcal infection 10.76 9.34 213 284713 48226 90295295
Oropharyngeal swelling 10.76 9.34 14 284912 924 90342597
Polydipsia psychogenic 10.70 9.34 6 284920 120 90343401
Blood prolactin decreased 10.70 9.34 5 284921 67 90343454
Myelodysplastic syndrome 10.69 9.34 32 284894 20871 90322650
Amyloid related imaging abnormality-oedema/effusion 10.69 9.34 14 284912 930 90342591
Diffuse large B-cell lymphoma 10.68 9.34 7 284919 8638 90334883
Blood chloride increased 10.67 9.34 28 284898 3182 90340339
Haemangioma of liver 10.65 9.34 17 284909 1353 90342168
Drooling 10.64 9.34 35 284891 4511 90339010
Abdominal symptom 10.64 9.34 10 284916 458 90343063
Lung opacity 10.62 9.34 3 284923 6099 90337422
Blunted affect 10.61 9.34 8 284918 269 90343252
Aspergillus infection 10.61 9.34 11 284915 10812 90332709
Electrocardiogram repolarisation abnormality 10.59 9.34 17 284909 1359 90342162
Dyslipidaemia 10.56 9.34 61 284865 10046 90333475
Narcolepsy 10.55 9.34 18 284908 1514 90342007
Glomerulonephritis minimal lesion 10.54 9.34 9 284917 363 90343158
Arrhythmia neonatal 10.51 9.34 5 284921 70 90343451
Hypnopompic hallucination 10.51 9.34 5 284921 70 90343451
Dementia 10.47 9.34 118 284808 23743 90319778
Premature labour 10.45 9.34 75 284851 13301 90330220
Cholecystectomy 10.42 9.34 68 284858 11687 90331834
Amniotic cavity infection 10.41 9.34 17 284909 1379 90342142
Anembryonic gestation 10.41 9.34 11 284915 581 90342940
Chills 10.37 9.34 511 284415 131470 90212051
Periodontal disease 10.35 9.34 19 284907 1693 90341828
Quadriparesis 10.34 9.34 24 284902 2525 90340996
Death 10.33 9.34 1267 283659 455284 89888237
Neurological examination abnormal 10.33 9.34 9 284917 373 90343148
Differential white blood cell count abnormal 10.30 9.34 14 284912 964 90342557
Electric shock sensation 10.23 9.34 18 284908 1552 90341969
Cytopenia 10.21 9.34 25 284901 17424 90326097
Placenta praevia 10.21 9.34 15 284911 1110 90342411
Victim of abuse 10.20 9.34 6 284920 132 90343389
Rapid eye movements sleep abnormal 10.20 9.34 6 284920 132 90343389
Tethered cord syndrome 10.19 9.34 8 284918 286 90343235
Pollakiuria 10.18 9.34 153 284773 32852 90310669
Procedural anxiety 10.17 9.34 13 284913 843 90342678
Haematotympanum 10.17 9.34 3 284923 9 90343512
Extensor plantar response 10.13 9.34 17 284909 1410 90342111
Factor XIII Inhibition 10.06 9.34 4 284922 35 90343486
Aspiration 10.04 9.34 84 284842 15609 90327912
Arrhythmia 10.04 9.34 188 284738 42144 90301377
Clumsiness 9.98 9.34 24 284902 2583 90340938
Neck injury 9.98 9.34 23 284903 2409 90341112
Induced labour 9.97 9.34 14 284912 994 90342527
Blood bilirubin increased 9.94 9.34 192 284734 43278 90300243
Pulse pressure abnormal 9.93 9.34 3 284923 10 90343511
Dark circles under eyes 9.93 9.34 11 284915 613 90342908
Breath odour 9.93 9.34 17 284909 1434 90342087
Chromaturia 9.88 9.34 98 284828 19089 90324432
Product substitution error 9.87 9.34 4 284922 37 90343484
Brief psychotic disorder, with postpartum onset 9.87 9.34 4 284922 37 90343484
Metabolic alkalosis 9.86 9.34 29 284897 3520 90340001
Oesophageal atresia 9.84 9.34 11 284915 619 90342902
Capillary fragility 9.84 9.34 7 284919 215 90343306
Dialysis hypotension 9.84 9.34 7 284919 215 90343306
Change of bowel habit 9.82 9.34 22 284904 2261 90341260
Female sexual dysfunction 9.80 9.34 5 284921 82 90343439
Skin reaction 9.78 9.34 28 284898 18525 90324996
Dissociative amnesia 9.78 9.34 4 284922 38 90343483
Lacunar infarction 9.77 9.34 28 284898 3349 90340172
Stag horn calculus 9.77 9.34 6 284920 143 90343378
Neck pain 9.77 9.34 278 284648 113685 90229836
Myoclonic epilepsy 9.76 9.34 18 284908 1609 90341912
Arterial occlusive disease 9.75 9.34 15 284911 12431 90331090
Lung neoplasm malignant 9.75 9.34 118 284808 24155 90319366
Uterine haemorrhage 9.74 9.34 35 284891 4717 90338804
Symptom recurrence 9.74 9.34 31 284895 3928 90339593
Atrioventricular block 9.74 9.34 54 284872 8761 90334760
Pupil fixed 9.71 9.34 21 284905 2107 90341414
Dysuria 9.69 9.34 176 284750 39225 90304296
Rubber sensitivity 9.69 9.34 25 284901 2812 90340709
Hypothyroidism 9.68 9.34 227 284699 52900 90290621
Affect lability 9.67 9.34 93 284833 17970 90325551
Epstein-Barr virus infection 9.60 9.34 11 284915 10333 90333188
Disturbance in social behaviour 9.59 9.34 32 284894 4156 90339365
Weight fluctuation 9.56 9.34 31 284895 19718 90323803
Blood pressure fluctuation 9.54 9.34 112 284814 52301 90291220
Sinus congestion 9.53 9.34 49 284877 27375 90316146
Genital rash 9.52 9.34 11 284915 642 90342879
Hyperactive pharyngeal reflex 9.51 9.34 3 284923 12 90343509
Renal aplasia 9.49 9.34 9 284917 417 90343104
Renal phospholipidosis 9.45 9.34 7 284919 229 90343292
CSF protein increased 9.43 9.34 12 284914 774 90342747
Biopsy muscle abnormal 9.42 9.34 4 284922 42 90343479
Dementia with Lewy bodies 9.40 9.34 9 284917 422 90343099
Implant site pruritus 9.40 9.34 11 284915 651 90342870
Mitochondrial toxicity 9.38 9.34 11 284915 652 90342869
Pulse abnormal 9.37 9.34 26 284900 3053 90340468
Back disorder 9.37 9.34 45 284881 25586 90317935
Drug dose omission by device 9.36 9.34 11 284915 10220 90333301
Paresis 9.35 9.34 24 284902 2690 90340831
Fibrocystic breast disease 9.35 9.34 15 284911 1199 90342322

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 1001.01 10.89 765 139723 25080 42455767
Depression 938.20 10.89 1468 139020 109895 42370952
Drug interaction 815.35 10.89 2319 138169 264680 42216167
Suicidal ideation 753.57 10.89 860 139628 47301 42433546
Intentional self-injury 555.74 10.89 435 140053 14767 42466080
Completed suicide 495.69 10.89 1026 139462 95439 42385408
Intentional overdose 493.09 10.89 721 139767 50735 42430112
Suicide attempt 472.53 10.89 667 139821 45433 42435414
Abnormal dreams 463.89 10.89 307 140181 7964 42472883
Anxiety 442.46 10.89 1111 139377 117449 42363398
Foetal exposure during pregnancy 342.39 10.89 583 139905 46728 42434119
Drug abuse 333.89 10.89 926 139562 103845 42377002
Paranoia 276.16 10.89 283 140205 13743 42467104
Nightmare 243.09 10.89 353 140135 24659 42456188
Agitation 240.95 10.89 604 139884 63710 42417137
Psychotic disorder 227.37 10.89 372 140116 28836 42452011
Aggression 223.31 10.89 467 140021 43696 42437151
Tremor 222.27 10.89 764 139724 96165 42384682
Febrile neutropenia 213.70 10.89 179 140309 185524 42295323
Irritability 213.24 10.89 354 140134 27774 42453073
Agitation neonatal 210.35 10.89 100 140388 1328 42479519
Psychiatric decompensation 201.81 10.89 142 140346 4080 42476767
Toxicity to various agents 199.45 10.89 1365 139123 227771 42253076
Pyrexia 195.54 10.89 657 139831 393385 42087462
Overdose 194.63 10.89 774 139714 104490 42376357
Tearfulness 191.62 10.89 128 140360 3372 42477475
Depressive symptom 178.17 10.89 127 140361 3726 42477121
Off label use 172.27 10.89 1317 139171 637018 41843829
Depression suicidal 171.25 10.89 116 140372 3129 42477718
Psychomotor skills impaired 160.72 10.89 135 140353 5069 42475778
Respiratory disorder neonatal 153.13 10.89 90 140398 1880 42478967
Erectile dysfunction 151.90 10.89 285 140203 24628 42456219
Sexual dysfunction 148.64 10.89 145 140343 6630 42474217
Maternal exposure during pregnancy 146.87 10.89 146 140342 6832 42474015
Drug withdrawal syndrome neonatal 146.67 10.89 120 140368 4341 42476506
Sopor 145.60 10.89 198 140290 13004 42467843
Dyskinesia 143.19 10.89 281 140207 25109 42455738
Somnolence 139.88 10.89 869 139619 140236 42340611
Atrial septal defect 138.45 10.89 150 140338 7769 42473078
Withdrawal syndrome 134.14 10.89 202 140286 14573 42466274
Disease progression 132.81 10.89 167 140321 143489 42337358
Loss of personal independence in daily activities 132.35 10.89 413 140075 49403 42431444
Priapism 131.07 10.89 132 140356 6275 42474572
Malignant neoplasm progression 128.93 10.89 101 140387 108299 42372548
Anaemia 128.30 10.89 483 140005 279795 42201052
Parkinsonism 125.85 10.89 165 140323 10458 42470389
Loss of libido 123.43 10.89 93 140395 2977 42477870
Akathisia 123.30 10.89 162 140326 10289 42470558
Neuroleptic malignant syndrome 122.73 10.89 239 140249 21233 42459614
Pneumonia 122.59 10.89 852 139636 421297 42059550
Restlessness 121.53 10.89 286 140202 28963 42451884
Drug withdrawal syndrome 118.50 10.89 236 140252 21313 42459534
Neutropenia 117.06 10.89 307 140181 199124 42281723
Confusional state 116.94 10.89 948 139540 166649 42314198
Acute kidney injury 115.86 10.89 723 139765 366614 42114233
Sepsis 112.36 10.89 313 140175 199021 42281826
Hypomania 112.14 10.89 81 140407 2427 42478420
Anger 111.17 10.89 173 140315 12845 42468002
Hallucination, visual 110.57 10.89 226 140262 20794 42460053
Dystonia 106.48 10.89 168 140320 12622 42468225
Obsessive-compulsive disorder 106.30 10.89 121 140367 6622 42474225
Pancytopenia 105.58 10.89 140 140348 117603 42363244
Exposure during pregnancy 103.17 10.89 134 140354 8414 42472433
Thrombocytopenia 101.96 10.89 306 140182 189973 42290874
Mania 99.76 10.89 147 140341 10400 42470447
Hallucination, auditory 98.12 10.89 176 140312 14688 42466159
Insomnia 94.74 10.89 691 139797 117562 42363285
Extrapyramidal disorder 94.18 10.89 183 140305 16229 42464618
Myelosuppression 92.52 10.89 12 140476 40449 42440398
Sedation 90.68 10.89 263 140225 30212 42450635
Hallucination 89.93 10.89 402 140086 57105 42423742
Delusion 86.64 10.89 166 140322 14568 42466279
Anorgasmia 85.90 10.89 51 140437 1086 42479761
Homicidal ideation 85.29 10.89 72 140416 2722 42478125
Hypertonia neonatal 84.64 10.89 41 140447 569 42480278
Blepharospasm 84.59 10.89 54 140434 1314 42479533
Septic shock 83.19 10.89 108 140380 91564 42389283
Tachyphrenia 82.09 10.89 54 140434 1385 42479462
Abnormal behaviour 81.34 10.89 231 140257 26220 42454627
Catatonia 80.33 10.89 101 140387 6138 42474709
Poisoning deliberate 80.09 10.89 130 140358 10004 42470843
Rash 79.68 10.89 560 139928 276394 42204453
Ventricular septal defect 78.08 10.89 84 140404 4315 42476532
Renal impairment 77.30 10.89 154 140334 110074 42370773
Tic 76.03 10.89 63 140425 2320 42478527
Intrusive thoughts 75.96 10.89 35 140453 431 42480416
Neuropathy peripheral 75.18 10.89 138 140350 101715 42379132
Cytokine release syndrome 74.11 10.89 27 140461 44500 42436347
Ascites 73.66 10.89 48 140440 56630 42424217
Head discomfort 73.43 10.89 88 140400 5089 42475758
Bradykinesia 73.20 10.89 90 140398 5346 42475501
Cytomegalovirus infection 72.87 10.89 10 140478 32296 42448551
Fall 72.50 10.89 1130 139358 233390 42247457
Muscle rigidity 72.31 10.89 137 140351 11922 42468925
Treatment noncompliance 71.93 10.89 280 140208 37392 42443455
Mood swings 69.45 10.89 113 140375 8713 42472134
Major depression 68.89 10.89 87 140401 5311 42475536
Electrocardiogram QT prolonged 68.19 10.89 326 140162 47619 42433228
Dystonic tremor 67.85 10.89 30 140458 333 42480514
Small for dates baby 65.86 10.89 84 140404 5179 42475668
Genital hypoaesthesia 65.28 10.89 26 140462 217 42480630
Multiple organ dysfunction syndrome 64.29 10.89 140 140348 96895 42383952
Derealisation 63.68 10.89 38 140450 817 42480030
Blood prolactin increased 63.61 10.89 56 140432 2242 42478605
Resting tremor 63.11 10.89 40 140448 961 42479886
Seizure 63.07 10.89 641 139847 119920 42360927
Psychomotor hyperactivity 61.43 10.89 121 140367 10837 42470010
Feeling jittery 61.42 10.89 75 140413 4423 42476424
General physical health deterioration 61.32 10.89 273 140215 150973 42329874
Pleural effusion 61.28 10.89 144 140344 97022 42383825
Patent ductus arteriosus 61.04 10.89 66 140422 3410 42477437
Obsessive thoughts 60.97 10.89 37 140451 821 42480026
COVID-19 60.94 10.89 188 140300 115760 42365087
Hyperhidrosis 60.88 10.89 508 139980 90004 42390843
Antipsychotic drug level increased 60.82 10.89 76 140412 4590 42476257
Loss of consciousness 60.35 10.89 515 139973 91839 42389008
Prostate cancer 59.12 10.89 37 140451 44606 42436241
Infusion related reaction 58.99 10.89 68 140420 60738 42420109
Amnesia 58.95 10.89 217 140271 28220 42452627
Inappropriate antidiuretic hormone secretion 58.40 10.89 152 140336 16389 42464458
Cogwheel rigidity 58.27 10.89 48 140440 1753 42479094
Depressed mood 57.64 10.89 189 140299 23195 42457652
Platelet count decreased 57.47 10.89 248 140240 138333 42342514
Oesophageal pain 57.31 10.89 38 140450 988 42479859
Myoclonus 56.38 10.89 153 140335 16912 42463935
Pneumocystis jirovecii pneumonia 56.31 10.89 8 140480 25173 42455674
Psychomotor retardation 56.30 10.89 71 140417 4328 42476519
Mucosal inflammation 54.97 10.89 49 140439 49325 42431522
Apathy 54.79 10.89 99 140389 8307 42472540
Bruxism 54.41 10.89 50 140438 2119 42478728
Prescribed overdose 54.33 10.89 127 140361 12800 42468047
Bradyphrenia 53.64 10.89 76 140412 5186 42475661
Large for dates baby 53.30 10.89 35 140453 895 42479952
Bipolar disorder 52.91 10.89 65 140423 3857 42476990
Disturbance in attention 52.22 10.89 216 140272 29650 42451197
Interstitial lung disease 52.14 10.89 113 140375 78349 42402498
Neonatal respiratory distress 52.12 10.89 35 140453 930 42479917
Homicide 51.38 10.89 34 140454 881 42479966
Social avoidant behaviour 50.72 10.89 59 140429 3305 42477542
Colitis microscopic 50.71 10.89 57 140431 3076 42477771
Tremor neonatal 50.25 10.89 27 140461 471 42480376
Thinking abnormal 48.81 10.89 86 140402 7075 42473772
Hepatic function abnormal 48.59 10.89 59 140429 51508 42429339
Anhedonia 47.30 10.89 88 140400 7552 42473295
Bone marrow failure 47.28 10.89 25 140463 33068 42447779
Tardive dyskinesia 47.00 10.89 83 140405 6841 42474006
Arthralgia 46.57 10.89 442 140046 204796 42276051
Fever neonatal 46.29 10.89 18 140470 140 42480707
C-reactive protein increased 46.10 10.89 87 140401 63473 42417374
Feeling abnormal 46.02 10.89 390 140098 69396 42411451
Stomatitis 45.94 10.89 59 140429 50270 42430577
Neonatal respiratory distress syndrome 45.74 10.89 65 140423 4448 42476399
Sleep disorder 45.56 10.89 293 140195 47802 42433045
Tumour lysis syndrome 45.42 10.89 9 140479 22222 42458625
Maternal exposure during breast feeding 45.27 10.89 39 140449 1516 42479331
Renal failure 45.07 10.89 283 140205 143443 42337404
Panic attack 44.78 10.89 107 140381 10938 42469909
Dyspnoea 44.33 10.89 1116 139372 441505 42039342
Blood creatine phosphokinase increased 44.28 10.89 292 140196 48046 42432801
Hyponatraemia 44.08 10.89 520 139968 100942 42379905
Diarrhoea 43.76 10.89 1171 139317 459678 42021169
Schizophrenia 43.63 10.89 103 140385 10447 42470400
Restless legs syndrome 43.22 10.89 97 140391 9517 42471330
Persecutory delusion 43.21 10.89 56 140432 3508 42477339
Conjunctivitis allergic 42.92 10.89 73 140415 5838 42475009
Haemangioma congenital 42.88 10.89 25 140463 514 42480333
Cardiogenic shock 42.60 10.89 33 140455 35607 42445240
Infantile apnoea 42.56 10.89 33 140455 1103 42479744
Pulmonary vasculitis 42.38 10.89 75 140413 6191 42474656
Blood creatinine increased 41.93 10.89 203 140285 109800 42371047
Erythema 41.91 10.89 200 140288 108593 42372254
Ejaculation failure 41.86 10.89 29 140459 812 42480035
Drug level increased 40.82 10.89 183 140305 26017 42454830
Neutrophil count decreased 40.76 10.89 93 140395 63322 42417525
Oromandibular dystonia 39.80 10.89 25 140463 591 42480256
Libido decreased 39.74 10.89 65 140423 5033 42475814
White blood cell count decreased 39.64 10.89 208 140280 110188 42370659
Bradycardia neonatal 39.64 10.89 34 140454 1314 42479533
Speech disorder 39.23 10.89 195 140293 28926 42451921
Product substitution issue 39.09 10.89 103 140385 11187 42469660
Pressure of speech 39.06 10.89 24 140464 545 42480302
Neurological symptom 38.59 10.89 95 140393 9896 42470951
Drug screen positive 38.23 10.89 57 140431 4074 42476773
Muscle strain 37.93 10.89 60 140428 4517 42476330
Arthritis 37.68 10.89 50 140438 42015 42438832
Ideas of reference 37.66 10.89 12 140476 47 42480800
Bronchopulmonary aspergillosis 37.39 10.89 9 140479 19420 42461427
Dysphoria 37.39 10.89 46 140442 2734 42478113
Death 37.31 10.89 1227 139261 469958 42010889
Neuritis 36.47 10.89 70 140418 6150 42474697
Muscle twitching 36.33 10.89 103 140385 11677 42469170
Apgar score low 36.09 10.89 28 140460 937 42479910
Disorientation 35.90 10.89 224 140264 36165 42444682
Drug dependence 35.84 10.89 190 140298 28904 42451943
Mydriasis 35.60 10.89 85 140403 8685 42472162
Rheumatoid arthritis 35.48 10.89 53 140435 42387 42438460
Depersonalisation/derealisation disorder 35.40 10.89 24 140464 648 42480199
Premature ejaculation 35.35 10.89 14 140474 115 42480732
Torticollis 35.18 10.89 32 140456 1338 42479509
Total lung capacity abnormal 35.11 10.89 57 140431 4386 42476461
Arteriosclerosis coronary artery 34.98 10.89 138 140350 18539 42462308
Cardiac failure 34.74 10.89 208 140280 106648 42374199
Tubulointerstitial nephritis 34.29 10.89 32 140456 31516 42449331
Overweight 34.21 10.89 41 140447 2371 42478476
Suspected suicide 34.20 10.89 68 140420 6131 42474716
Salivary hypersecretion 34.06 10.89 96 140392 10847 42470000
Impulsive behaviour 34.03 10.89 41 140447 2384 42478463
Haemophagocytic lymphohistiocytosis 33.99 10.89 9 140479 18213 42462634
Pulmonary artery stenosis 33.86 10.89 18 140470 307 42480540
Mycotic allergy 33.67 10.89 59 140429 4832 42476015
Atrial fibrillation 33.64 10.89 296 140192 139297 42341550
Pruritus 33.47 10.89 430 140058 188341 42292506
Exposure via breast milk 33.33 10.89 41 140447 2436 42478411
Dissociation 33.16 10.89 51 140437 3747 42477100
Urinary retention 32.79 10.89 245 140243 41969 42438878
Spirometry abnormal 32.77 10.89 60 140428 5086 42475761
Inappropriate schedule of product administration 32.60 10.89 184 140304 95718 42385129
Orthostatic hypotension 32.58 10.89 192 140296 30378 42450469
Alcoholism 32.39 10.89 44 140444 2886 42477961
Mite allergy 32.34 10.89 59 140429 4987 42475860
Gout 32.25 10.89 27 140461 28028 42452819
Myasthenia gravis 32.00 10.89 7 140481 16130 42464717
Personality change 31.87 10.89 63 140425 5656 42475191
Inflammation 31.59 10.89 39 140449 33808 42447039
Enuresis 31.49 10.89 42 140446 2706 42478141
Alcohol interaction 31.45 10.89 37 140451 2098 42478749
Myelodysplastic syndrome 31.30 10.89 18 140470 22727 42458120
Affective disorder 31.24 10.89 64 140424 5896 42474951
End stage renal disease 31.22 10.89 8 140480 16550 42464297
Post concussion syndrome 31.00 10.89 14 140474 164 42480683
Urticaria 30.97 10.89 132 140356 73904 42406943
Platelet aggregation abnormal 30.85 10.89 9 140479 24 42480823
Dermatillomania 30.71 10.89 11 140477 66 42480781
Foaming at mouth 30.46 10.89 26 140462 998 42479849
Antidepressant drug level increased 30.41 10.89 15 140473 217 42480630
Generalised tonic-clonic seizure 30.29 10.89 169 140319 26210 42454637
Parasomnia 30.22 10.89 19 140469 450 42480397
Haemoglobin decreased 30.14 10.89 285 140203 132186 42348661
Suicidal behaviour 30.07 10.89 31 140457 1515 42479332
Morose 30.07 10.89 8 140480 13 42480834
Eczema 30.04 10.89 41 140447 34045 42446802
Dust allergy 30.03 10.89 59 140429 5273 42475574
Polyneuropathy 29.91 10.89 12 140476 18649 42462198
Oedema peripheral 29.59 10.89 296 140192 135780 42345067
Negativism 29.13 10.89 18 140470 413 42480434
Liver disorder 28.97 10.89 54 140434 39590 42441257
Maternal drugs affecting foetus 28.65 10.89 48 140440 3791 42477056
Meconium aspiration syndrome 28.65 10.89 10 140478 55 42480792
Male orgasmic disorder 28.60 10.89 12 140476 116 42480731
Grandiosity 28.56 10.89 16 140472 304 42480543
Trismus 28.44 10.89 41 140447 2843 42478004
Rash maculo-papular 28.38 10.89 50 140438 37453 42443394
Mycobacterial peritonitis 28.22 10.89 13 140475 160 42480687
Congenital monorchidism 28.20 10.89 7 140481 7 42480840
Bipolar I disorder 28.04 10.89 23 140465 835 42480012
Newborn persistent pulmonary hypertension 27.98 10.89 12 140476 123 42480724
Antineutrophil cytoplasmic antibody positive 27.93 10.89 51 140437 4314 42476533
Delusion of replacement 27.87 10.89 14 140474 211 42480636
Leukopenia 27.86 10.89 139 140349 74607 42406240
Temperature regulation disorder 27.68 10.89 26 140462 1133 42479714
Neonatal behavioural syndrome 27.66 10.89 13 140475 168 42480679
Nasopharyngitis 27.56 10.89 163 140325 83833 42397014
Aspergillus infection 27.39 10.89 9 140479 15828 42465019
COVID-19 pneumonia 27.14 10.89 19 140469 21594 42459253
Persistent foetal circulation 27.02 10.89 16 140472 339 42480508
Neonatal respiratory acidosis 26.99 10.89 10 140478 67 42480780
Graft versus host disease 26.90 10.89 5 140483 12920 42467927
Prostatic pain 26.85 10.89 16 140472 343 42480504
Hypophosphataemia 26.85 10.89 18 140470 20927 42459920
Infection 26.83 10.89 238 140250 111830 42369017
Semen discolouration 26.82 10.89 9 140479 43 42480804
Nephropathy toxic 26.71 10.89 11 140477 16827 42464020
Synovitis 26.65 10.89 9 140479 15558 42465289
Sedation complication 26.62 10.89 40 140448 2879 42477968
Anaphylactic shock 26.58 10.89 23 140465 23494 42457353
Acute psychosis 26.42 10.89 34 140454 2115 42478732
Neonatal tachypnoea 26.29 10.89 16 140472 357 42480490
Thrombotic microangiopathy 26.28 10.89 8 140480 14774 42466073
Pneumonitis 26.14 10.89 62 140426 41656 42439191
Peripheral swelling 26.13 10.89 182 140306 90088 42390759
Rapid eye movement sleep behaviour disorder 26.10 10.89 15 140473 300 42480547
Basal cell carcinoma 25.98 10.89 22 140466 22711 42458136
Self esteem decreased 25.98 10.89 18 140470 504 42480343
Ejaculation disorder 25.98 10.89 24 140464 1024 42479823
Mental disorder 25.92 10.89 123 140365 17906 42462941
Hypotonia neonatal 25.75 10.89 28 140460 1456 42479391
Respiratory failure 25.71 10.89 284 140204 127848 42352999
Wrong patient received product 25.68 10.89 44 140444 3539 42477308
Joint swelling 25.63 10.89 126 140362 67896 42412951
Male sexual dysfunction 25.55 10.89 16 140472 376 42480471
Macrophages increased 25.53 10.89 12 140476 155 42480692
Patient elopement 25.40 10.89 12 140476 157 42480690
Hypomagnesaemia 25.37 10.89 34 140454 28454 42452393
Coma 25.28 10.89 279 140209 53275 42427572
Abdominal distension 25.27 10.89 136 140352 71599 42409248
Dementia with Lewy bodies 25.20 10.89 22 140466 871 42479976
Bacterial infection 25.11 10.89 33 140455 27846 42453001
Agitated depression 25.09 10.89 14 140474 264 42480583
Psychotic symptom 25.08 10.89 35 140453 2355 42478492
Hyperphosphataemia 25.07 10.89 6 140482 12998 42467849
Cerebral infarction 25.02 10.89 40 140448 31129 42449718
Drug ineffective 24.93 10.89 1766 138722 628431 41852416
Hypocalcaemia 24.91 10.89 38 140450 30135 42450712
Acute myeloid leukaemia 24.87 10.89 22 140466 22234 42458613
Dysphemia 24.82 10.89 31 140457 1871 42478976
Hyporesponsive to stimuli 24.80 10.89 28 140460 1518 42479329
Acute respiratory distress syndrome 24.78 10.89 38 140450 30070 42450777
Rapid eye movements sleep abnormal 24.68 10.89 12 140476 168 42480679
Middle insomnia 24.65 10.89 69 140419 7764 42473083
Mycobacterium fortuitum infection 24.65 10.89 16 140472 401 42480446
Obsessive-compulsive symptom 24.60 10.89 13 140475 219 42480628
Weight increased 24.59 10.89 496 139992 107487 42373360
Persistent depressive disorder 24.35 10.89 17 140471 482 42480365
Tension 24.25 10.89 35 140453 2429 42478418
Balance disorder 24.25 10.89 252 140236 47393 42433454
Neonatal respiratory arrest 24.23 10.89 8 140480 36 42480811
Eosinophilic granulomatosis with polyangiitis 24.21 10.89 73 140415 8565 42472282
Loose associations 24.20 10.89 9 140479 61 42480786
Phospholipidosis 24.20 10.89 9 140479 61 42480786
Hyperreflexia 24.17 10.89 43 140445 3564 42477283
Radiologically isolated syndrome 24.17 10.89 6 140482 6 42480841
Libido disorder 24.13 10.89 15 140473 348 42480499
Colitis 24.10 10.89 76 140412 46496 42434351
Capillaritis 23.93 10.89 33 140455 2195 42478652
Cytomegalovirus viraemia 23.91 10.89 3 140485 10374 42470473
Deep vein thrombosis 23.86 10.89 152 140336 76805 42404042
Orgasm abnormal 23.76 10.89 11 140477 137 42480710
Bronchiectasis 23.76 10.89 15 140473 18004 42462843
Sleep terror 23.75 10.89 38 140450 2888 42477959
Ejaculation delayed 23.71 10.89 14 140474 295 42480552
Growth hormone-producing pituitary tumour 23.69 10.89 11 140477 138 42480709
Neonatal anoxia 23.59 10.89 5 140483 0 42480847
Hypoalbuminaemia 23.49 10.89 11 140477 15599 42465248
Palmar-plantar erythrodysaesthesia syndrome 23.42 10.89 20 140468 20562 42460285
Hyperkalaemia 23.39 10.89 162 140326 80296 42400551
Maternal exposure timing unspecified 23.14 10.89 15 140473 375 42480472
Premature baby 23.13 10.89 143 140345 23010 42457837
Chronic kidney disease 23.13 10.89 79 140409 47162 42433685
Aorta hypoplasia 23.11 10.89 10 140478 105 42480742
Hallucinations, mixed 23.08 10.89 41 140447 3394 42477453
Drug reaction with eosinophilia and systemic symptoms 22.96 10.89 67 140421 42008 42438839
Drug intolerance 22.86 10.89 163 140325 80261 42400586
Schizophreniform disorder 22.82 10.89 9 140479 73 42480774
Medication error 22.76 10.89 187 140301 32967 42447880
Neonatal asphyxia 22.72 10.89 16 140472 460 42480387
Weight decrease neonatal 22.44 10.89 14 140474 327 42480520
Energy increased 22.29 10.89 26 140462 1461 42479386
Nervousness 22.20 10.89 96 140392 13436 42467411
Pneumonia bacterial 22.20 10.89 12 140476 15680 42465167
Drug eruption 22.16 10.89 26 140462 23049 42457798
Attention deficit hyperactivity disorder 22.06 10.89 38 140450 3070 42477777
Oedematous pancreatitis 21.98 10.89 19 140469 742 42480105
Hypertonia 21.97 10.89 50 140438 4951 42475896
Pulmonary fibrosis 21.95 10.89 157 140331 26524 42454323
Excessive masturbation 21.93 10.89 10 140478 120 42480727
Cytomegalovirus infection reactivation 21.86 10.89 5 140483 11173 42469674
Slow speech 21.50 10.89 28 140460 1762 42479085
Cognitive disorder 21.48 10.89 189 140299 33983 42446864
Cardiac failure acute 21.47 10.89 9 140479 13624 42467223
Fungal infection 21.44 10.89 20 140468 19702 42461145
Prader-Willi syndrome 21.44 10.89 6 140482 13 42480834
Hyperacusis 21.42 10.89 21 140467 966 42479881
Urinary hesitation 21.40 10.89 37 140451 2998 42477849
Lymphadenopathy 21.38 10.89 49 140439 33316 42447531
Haematotoxicity 21.31 10.89 5 140483 10980 42469867
Transaminases increased 21.31 10.89 48 140440 32837 42448010
Congenital hydronephrosis 21.22 10.89 19 140469 778 42480069
Immune effector cell-associated neurotoxicity syndrome 21.16 10.89 3 140485 9458 42471389
Gastrointestinal motility disorder 21.11 10.89 36 140452 2885 42477962
Psoriatic arthropathy 21.04 10.89 31 140457 24936 42455911
Compulsive shopping 20.87 10.89 15 140473 446 42480401
Violence-related symptom 20.86 10.89 16 140472 526 42480321
Breech presentation 20.83 10.89 11 140477 185 42480662
Negative thoughts 20.80 10.89 18 140470 704 42480143
Somnambulism 20.72 10.89 39 140449 3376 42477471
Anorectal discomfort 20.71 10.89 31 140457 2224 42478623
Infantile vomiting 20.59 10.89 9 140479 97 42480750
C-reactive protein abnormal 20.57 10.89 3 140485 9258 42471589
Generalised anxiety disorder 20.51 10.89 20 140468 914 42479933
Neonatal epileptic seizure 20.49 10.89 8 140480 63 42480784
Congenital megaureter 20.31 10.89 10 140478 144 42480703
Haemorrhagic hepatic cyst 20.30 10.89 6 140482 17 42480830
Bezoar 20.28 10.89 23 140465 1253 42479594
Cryptorchism 20.25 10.89 29 140459 1998 42478849
Prescription drug used without a prescription 20.20 10.89 34 140454 2696 42478151
Cyanosis neonatal 20.20 10.89 13 140475 321 42480526
Product complaint 20.15 10.89 54 140434 5923 42474924
Congenital multiplex arthrogryposis 19.99 10.89 12 140476 261 42480586
Cytopenia 19.91 10.89 17 140471 17480 42463367
Mood altered 19.91 10.89 79 140409 10639 42470208
Respiratory arrest 19.87 10.89 161 140327 28263 42452584
Gastric hypomotility 19.83 10.89 11 140477 205 42480642
Transplant rejection 19.80 10.89 10 140478 13578 42467269
Hereditary haemorrhagic telangiectasia 19.69 10.89 7 140481 41 42480806
Blood pressure systolic increased 19.65 10.89 39 140449 27929 42452918
Sexual activity increased 19.58 10.89 6 140482 20 42480827
Euphoric mood 19.49 10.89 56 140432 6397 42474450
Rash pruritic 19.46 10.89 52 140436 33551 42447296
Second primary malignancy 19.30 10.89 4 140484 9571 42471276
Hyperaesthesia 19.29 10.89 53 140435 5899 42474948
Social anxiety disorder 19.29 10.89 16 140472 590 42480257
Hyperprolactinaemia 19.23 10.89 29 140459 2094 42478753
Meningomyelocele 19.18 10.89 11 140477 219 42480628
Blood bilirubin increased 19.13 10.89 73 140415 42179 42438668
Blood uric acid increased 19.09 10.89 14 140474 15533 42465314
Torsade de pointes 19.01 10.89 67 140421 8527 42472320
Hepatic enzyme increased 18.91 10.89 82 140406 45702 42435145
Inborn error of lipid metabolism 18.87 10.89 4 140484 0 42480847
Muscle hypoxia 18.87 10.89 4 140484 0 42480847
Obstructive airways disorder 18.83 10.89 143 140345 24616 42456231
Pseudomonas infection 18.70 10.89 15 140473 15908 42464939
Influenza 18.66 10.89 124 140364 62051 42418796
Implant site extravasation 18.56 10.89 14 140474 449 42480398
Arthropathy 18.53 10.89 44 140444 29553 42451294
Adrenal insufficiency 18.52 10.89 21 140467 18903 42461944
High-pitched crying 18.47 10.89 5 140483 9 42480838
Incontinence 18.47 10.89 57 140431 6773 42474074
Cellulitis 18.40 10.89 123 140365 61462 42419385
Cerebral haemorrhage neonatal 18.37 10.89 12 140476 304 42480543
Blood ethanol increased 18.37 10.89 14 140474 456 42480391
Hypersomnia 18.37 10.89 96 140392 14522 42466325
Hypospadias 18.34 10.89 38 140450 3529 42477318
Neonatal hypoxia 18.27 10.89 15 140473 545 42480302
Congenital supraventricular tachycardia 18.13 10.89 5 140483 10 42480837
Feelings of worthlessness 18.10 10.89 12 140476 312 42480535
Hypersensitivity 18.07 10.89 152 140336 72218 42408629
Physical assault 18.05 10.89 20 140468 1062 42479785
Viral diarrhoea 18.03 10.89 12 140476 314 42480533
Strabismus congenital 18.00 10.89 6 140482 28 42480819
Gastrooesophageal reflux disease 17.90 10.89 227 140261 44796 42436051
Coloboma 17.90 10.89 9 140479 136 42480711
Periodic limb movement disorder 17.84 10.89 9 140479 137 42480710
Congenital pulmonary valve atresia 17.83 10.89 7 140481 56 42480791
Sleep inertia 17.82 10.89 6 140482 29 42480818
Epstein-Barr virus infection 17.75 10.89 5 140483 9713 42471134
Panic reaction 17.65 10.89 25 140463 1705 42479142
Drug resistance 17.64 10.89 56 140432 34192 42446655
Hypoglycaemia neonatal 17.56 10.89 28 140460 2122 42478725
Abulia 17.49 10.89 16 140472 674 42480173
Acute graft versus host disease 17.48 10.89 3 140485 8212 42472635
Localised infection 17.46 10.89 25 140463 20348 42460499
Therapeutic response unexpected 17.35 10.89 79 140409 11302 42469545
Metastases to bone 17.33 10.89 14 140474 14795 42466052
Leukaemoid reaction 17.28 10.89 9 140479 147 42480700
Painful erection 17.23 10.89 12 140476 339 42480508
Compulsive sexual behaviour 17.22 10.89 11 140477 268 42480579
Neonatal disorder 17.19 10.89 17 140471 790 42480057
Gangrene neonatal 17.18 10.89 10 140478 205 42480642
Shunt malfunction 17.15 10.89 11 140477 270 42480577
Pharyngeal dystonia 17.12 10.89 7 140481 63 42480784
Herpes zoster 17.07 10.89 68 140420 38809 42442038
Shock haemorrhagic 17.04 10.89 17 140471 16225 42464622
Parkinsonism hyperpyrexia syndrome 16.98 10.89 12 140476 347 42480500
Alveolar bone resorption 16.96 10.89 5 140483 14 42480833
Confabulation 16.96 10.89 9 140479 153 42480694
Crying 16.95 10.89 53 140435 6341 42474506
Hepatotoxicity 16.91 10.89 36 140452 25131 42455716
Wrong product administered 16.87 10.89 52 140436 6174 42474673
Respiratory symptom 16.87 10.89 77 140411 11029 42469818
Flat affect 16.86 10.89 19 140469 1028 42479819
Septum pellucidum agenesis 16.83 10.89 7 140481 66 42480781
Dysarthria 16.82 10.89 203 140285 39604 42441243
Gastrointestinal haemorrhage 16.78 10.89 224 140264 97502 42383345
Hepatitis 16.77 10.89 41 140447 27259 42453588
Antidepressant drug level below therapeutic 16.71 10.89 5 140483 15 42480832
Hypercalcaemia 16.65 10.89 21 140467 18037 42462810
Disturbance in sexual arousal 16.65 10.89 9 140479 159 42480688
Enterocolitis 16.55 10.89 6 140482 9923 42470924
Activation syndrome 16.55 10.89 9 140479 161 42480686
Hypersexuality 16.50 10.89 24 140464 1678 42479169
Acute myocardial infarction 16.47 10.89 118 140370 58047 42422800
Forced expiratory volume decreased 16.46 10.89 59 140429 7571 42473276
Chorea 16.44 10.89 22 140466 1422 42479425
Emotional disorder 16.43 10.89 52 140436 6262 42474585
Treatment failure 16.33 10.89 130 140358 62494 42418353
Post-traumatic stress disorder 16.30 10.89 28 140460 2257 42478590
Oesophageal ulcer haemorrhage 16.29 10.89 12 140476 371 42480476
Tongue biting 16.28 10.89 19 140469 1068 42479779
Genital anaesthesia 16.24 10.89 5 140483 17 42480830
Disseminated intravascular coagulation 16.22 10.89 36 140452 24758 42456089
Lymphomatoid papulosis 16.08 10.89 10 140478 232 42480615
Dyspnoea exertional 16.08 10.89 98 140390 50050 42430797
Blood pressure fluctuation 16.07 10.89 41 140447 26867 42453980
Product use in unapproved indication 16.05 10.89 474 140014 183982 42296865
Appendicitis 16.03 10.89 27 140461 20586 42460261
Respiratory dyskinesia 16.02 10.89 5 140483 18 42480829
Administration related reaction 16.02 10.89 9 140479 172 42480675
Unmasking of previously unidentified disease 15.99 10.89 20 140468 1209 42479638
Neoplasm progression 15.95 10.89 46 140442 28954 42451893
Onychomycosis 15.90 10.89 31 140457 2755 42478092
Skin turgor decreased 15.89 10.89 14 140474 561 42480286
Hepatic failure 15.88 10.89 68 140420 38032 42442815
Patient isolation 15.85 10.89 6 140482 43 42480804
Illness anxiety disorder 15.79 10.89 9 140479 177 42480670
Poverty of thought content 15.73 10.89 6 140482 44 42480803
Rales 15.72 10.89 9 140479 11391 42469456
Muscle tightness 15.63 10.89 47 140441 5506 42475341
Apallic syndrome 15.63 10.89 11 140477 316 42480531
Tongue spasm 15.62 10.89 6 140482 45 42480802
Dissociative identity disorder 15.61 10.89 5 140483 20 42480827
Transient tachypnoea of the newborn 15.57 10.89 9 140479 182 42480665
Normochromic normocytic anaemia 15.54 10.89 65 140423 8966 42471881
Food interaction 15.54 10.89 18 140470 1004 42479843
Oral herpes 15.52 10.89 3 140485 7541 42473306
Immune reconstitution inflammatory syndrome 15.49 10.89 7 140481 10136 42470711
Cholangitis 15.47 10.89 8 140480 10719 42470128
Abdominal pain 15.47 10.89 494 139994 189977 42290870
Memory impairment 15.45 10.89 242 140246 49980 42430867
Obesity 15.41 10.89 100 140388 16359 42464488
Blood test abnormal 15.36 10.89 12 140476 12894 42467953
Ejection fraction decreased 15.34 10.89 31 140457 22056 42458791
Gun shot wound 15.32 10.89 18 140470 1019 42479828
Polyhydramnios 15.32 10.89 10 140478 253 42480594
Grunting 15.30 10.89 13 140475 496 42480351
Plasma cell myeloma 15.25 10.89 93 140395 47485 42433362
Obsessive rumination 15.23 10.89 4 140484 6 42480841
Hyperuricaemia 15.20 10.89 6 140482 9418 42471429
Motor developmental delay 15.19 10.89 15 140473 696 42480151
Cough 15.17 10.89 459 140029 177644 42303203
Blood triglycerides increased 15.14 10.89 97 140391 15799 42465048
Foetal growth restriction 15.14 10.89 45 140443 5238 42475609
Paraneoplastic rash 15.13 10.89 7 140481 87 42480760
Aspartate aminotransferase increased 15.08 10.89 172 140316 76991 42403856
Anaphylactic reaction 15.07 10.89 81 140407 42662 42438185
Tongue injury 15.06 10.89 9 140479 194 42480653
Rebound psychosis 15.06 10.89 9 140479 194 42480653
Muscle contracture 15.03 10.89 21 140467 1414 42479433
Decreased interest 15.01 10.89 30 140458 2715 42478132
Psychiatric symptom 15.00 10.89 39 140449 4202 42476645
Action tremor 14.99 10.89 7 140481 89 42480758
Impulse-control disorder 14.96 10.89 22 140466 1553 42479294
Morbid thoughts 14.94 10.89 9 140479 197 42480650
Kidney transplant rejection 14.90 10.89 5 140483 8678 42472169
Iron deficiency 14.87 10.89 9 140479 11052 42469795
Peritonitis 14.87 10.89 24 140464 18609 42462238
Scaphocephaly 14.87 10.89 6 140482 52 42480795
Lethargy 14.83 10.89 227 140261 46663 42434184
Alanine aminotransferase increased 14.69 10.89 204 140284 88202 42392645
Left ventricular false tendon 14.67 10.89 6 140482 54 42480793
Muscle contractions involuntary 14.61 10.89 25 140463 2009 42478838
Congenital hearing disorder 14.59 10.89 7 140481 95 42480752
Libido increased 14.49 10.89 17 140471 961 42479886
Congenital coronary artery malformation 14.48 10.89 6 140482 56 42480791
Strabismus 14.48 10.89 27 140461 2321 42478526
Haematochezia 14.47 10.89 123 140365 58313 42422534
Pathogen resistance 14.46 10.89 10 140478 11440 42469407
Rhinitis 14.43 10.89 11 140477 11966 42468881
Oesophageal carcinoma 14.33 10.89 7 140481 9689 42471158
Social problem 14.33 10.89 19 140469 1217 42479630
Arteriosclerosis 14.30 10.89 105 140383 17884 42462963
Dysgraphia 14.27 10.89 28 140460 2500 42478347
Malpositioned teeth 14.25 10.89 5 140483 28 42480819
Transposition of the great vessels 14.23 10.89 12 140476 453 42480394
Hepatocellular injury 14.20 10.89 36 140452 23642 42457205
Klebsiella infection 14.18 10.89 10 140478 11322 42469525
Nasal cavity packing 14.16 10.89 3 140485 0 42480847
Haemorrhage foetal 14.16 10.89 3 140485 0 42480847
Infantile colic 14.16 10.89 3 140485 0 42480847
Enteric neuropathy 14.16 10.89 3 140485 0 42480847
Arterial ligation 14.16 10.89 3 140485 0 42480847
Foetal damage 14.16 10.89 3 140485 0 42480847
Constricted affect 14.16 10.89 3 140485 0 42480847
Immunosuppressant drug level increased 14.08 10.89 4 140484 7727 42473120
Hyperphagia 13.99 10.89 22 140466 1648 42479199
Renal injury 13.89 10.89 12 140476 12268 42468579
Metabolic acidosis 13.82 10.89 107 140381 51751 42429096
Full blood count abnormal 13.80 10.89 155 140333 29721 42451126
Cataract congenital 13.79 10.89 7 140481 108 42480739
Proteinuria 13.74 10.89 35 140453 22948 42457899
Granulocytopenia 13.67 10.89 53 140435 7061 42473786
Moaning 13.66 10.89 16 140472 903 42479944
Decreased appetite 13.58 10.89 510 139978 192627 42288220
Delirium 13.57 10.89 246 140242 52273 42428574
Self-injurious ideation 13.47 10.89 23 140465 1845 42479002
Pyromania 13.43 10.89 5 140483 34 42480813
Progressive multifocal leukoencephalopathy 13.38 10.89 11 140477 11525 42469322
Hypernatraemia 13.38 10.89 67 140421 9965 42470882
Fallot's tetralogy 13.36 10.89 8 140480 173 42480674
Acoustic stimulation tests abnormal 13.31 10.89 6 140482 70 42480777
Foetal megacystis 13.31 10.89 6 140482 70 42480777
Red blood cell elliptocytes present 13.29 10.89 7 140481 117 42480730
Drug dispensed to wrong patient 13.13 10.89 12 140476 505 42480342
Eye movement disorder 13.12 10.89 41 140447 4904 42475943
Foetal death 13.12 10.89 9 140479 248 42480599
Poor feeding infant 13.09 10.89 15 140473 827 42480020
Postmortem blood drug level increased 13.05 10.89 12 140476 509 42480338
Sexually inappropriate behaviour 13.04 10.89 13 140475 610 42480237
Acute generalised exanthematous pustulosis 13.02 10.89 6 140482 8589 42472258
Selective mutism 13.01 10.89 6 140482 74 42480773
Osteonecrosis of jaw 13.01 10.89 27 140461 19022 42461825
Dementia 12.99 10.89 96 140392 16384 42464463
Pericardial effusion 12.98 10.89 51 140437 29224 42451623
Enteritis 12.94 10.89 10 140478 10806 42470041
Disinhibition 12.94 10.89 35 140453 3860 42476987
Talipes 12.91 10.89 25 140463 2211 42478636
Reversible cerebral vasoconstriction syndrome 12.90 10.89 14 140474 726 42480121
Myalgia 12.86 10.89 411 140077 95669 42385178
Anion gap abnormal 12.80 10.89 11 140477 426 42480421
Heat stroke 12.80 10.89 17 140471 1091 42479756
Posterior reversible encephalopathy syndrome 12.80 10.89 14 140474 12807 42468040
Guillain-Barre syndrome 12.79 10.89 4 140484 7259 42473588
Pregnancy 12.78 10.89 9 140479 259 42480588
Cleft palate 12.77 10.89 13 140475 626 42480221
Dysentery 12.74 10.89 11 140477 429 42480418
Oxygen saturation decreased 12.72 10.89 144 140344 64543 42416304
Orthosis user 12.69 10.89 4 140484 15 42480832
Platelet aggregation decreased 12.69 10.89 4 140484 15 42480832
Neutrophil count increased 12.69 10.89 110 140378 19694 42461153
Rhinovirus infection 12.67 10.89 3 140485 6545 42474302
Diverticulitis 12.62 10.89 36 140452 22737 42458110
Mixed dementia 12.60 10.89 9 140479 265 42480582
Antidepressant drug level above therapeutic 12.60 10.89 9 140479 265 42480582
Flashback 12.59 10.89 7 140481 131 42480716
Squamous cell carcinoma of skin 12.59 10.89 14 140474 12712 42468135
Hypotension 12.52 10.89 708 139780 256923 42223924
Large intestine perforation 12.49 10.89 8 140480 9528 42471319
Drug tolerance increased 12.48 10.89 11 140477 441 42480406
Lower respiratory tract infection 12.45 10.89 82 140406 41124 42439723
Naevus flammeus 12.45 10.89 8 140480 197 42480650
Telangiectasia 12.40 10.89 17 140471 1125 42479722
Poisoning 12.38 10.89 87 140401 14612 42466235
Haemolytic anaemia 12.37 10.89 13 140475 12114 42468733
Panic disorder 12.37 10.89 18 140470 1259 42479588
Hepatic encephalopathy 12.37 10.89 22 140466 16420 42464427
Dermatitis acneiform 12.36 10.89 5 140483 7734 42473113
Altered state of consciousness 12.33 10.89 52 140436 29207 42451640
Behaviour disorder 12.31 10.89 51 140437 7003 42473844
Mitochondrial myopathy acquired 12.30 10.89 4 140484 17 42480830
Skin indentation 12.30 10.89 4 140484 17 42480830
Diffuse large B-cell lymphoma 12.29 10.89 8 140480 9446 42471401
Sleep disorder due to a general medical condition 12.28 10.89 99 140389 17354 42463493
Drug screen false positive 12.25 10.89 15 140473 887 42479960
Accidental exposure to product 12.23 10.89 31 140457 20362 42460485
Diffuse vasculitis 12.21 10.89 6 140482 86 42480761
Intraventricular haemorrhage neonatal 12.21 10.89 10 140478 362 42480485
Personality disorder 12.16 10.89 17 140471 1146 42479701
Bankruptcy 12.11 10.89 4 140484 18 42480829
Congenital gastric anomaly 12.09 10.89 3 140485 3 42480844
Colostomy infection 12.09 10.89 3 140485 3 42480844
Abdominoplasty 12.09 10.89 3 140485 3 42480844
Cardiac failure congestive 12.01 10.89 204 140284 85398 42395449
Posture abnormal 11.97 10.89 26 140462 2495 42478352
Breast pain 11.96 10.89 20 140468 1577 42479270
Differential white blood cell count abnormal 11.96 10.89 21 140467 1723 42479124
Blood lactate dehydrogenase increased 11.85 10.89 45 140443 26036 42454811
Neuralgia 11.81 10.89 44 140444 25603 42455244
Depressed level of consciousness 11.81 10.89 223 140265 47747 42433100
Hepatic cirrhosis 11.78 10.89 30 140458 19672 42461175
Anxiety disorder due to a general medical condition 11.77 10.89 4 140484 20 42480827
Electrocardiogram QT interval abnormal 11.74 10.89 6 140482 94 42480753
Congenital nystagmus 11.74 10.89 6 140482 94 42480753
Upper respiratory tract infection 11.72 10.89 86 140402 42087 42438760
Renal tubular necrosis 11.72 10.89 27 140461 18327 42462520
Chills 11.69 10.89 229 140259 93837 42387010
Emotional disorder of childhood 11.68 10.89 5 140483 51 42480796
Maculopathy 11.66 10.89 16 140472 1059 42479788
Blood urea increased 11.64 10.89 62 140426 32731 42448116
Dyskinesia neonatal 11.63 10.89 3 140485 4 42480843
Morvan syndrome 11.61 10.89 4 140484 21 42480826
Emotional poverty 11.60 10.89 13 140475 699 42480148
Coagulopathy 11.58 10.89 36 140452 22126 42458721
Feeling drunk 11.54 10.89 24 140464 2234 42478613
Hippocampal sclerosis 11.47 10.89 7 140481 157 42480690
Negative symptoms in schizophrenia 11.46 10.89 6 140482 99 42480748
Pulmonary microemboli 11.46 10.89 4 140484 22 42480825
Velopharyngeal incompetence 11.46 10.89 4 140484 22 42480825
Haemorrhage 11.45 10.89 136 140352 60427 42420420
Asphyxia 11.39 10.89 56 140432 8270 42472577
Umbilical cord abnormality 11.35 10.89 5 140483 55 42480792
Cerebrovascular accident 11.34 10.89 239 140249 96921 42383926
Lymphopenia 11.29 10.89 35 140453 21528 42459319
Neurotoxicity 11.27 10.89 40 140448 23611 42457236
Poverty of speech 11.27 10.89 8 140480 233 42480614
Multiple-drug resistance 11.27 10.89 5 140483 7317 42473530
Tuberculosis 11.26 10.89 10 140478 10089 42470758
Drug dose titration not performed 11.26 10.89 10 140478 405 42480442
Loss of employment 11.25 10.89 11 140477 504 42480343
Movement disorder 11.24 10.89 85 140403 14613 42466234
Helicobacter infection 11.21 10.89 26 140462 2606 42478241
Urinary incontinence 11.21 10.89 115 140373 21553 42459294
Logorrhoea 11.17 10.89 27 140461 2780 42478067
Epistaxis 11.17 10.89 154 140334 66672 42414175
Affect lability 11.17 10.89 34 140454 4010 42476837
Hyperbilirubinaemia neonatal 11.14 10.89 14 140474 850 42479997
Bladder dilatation 11.14 10.89 20 140468 1670 42479177
Pancreatic carcinoma 11.11 10.89 9 140479 9497 42471350
Anal abscess 11.11 10.89 6 140482 7844 42473003
Autism spectrum disorder 11.11 10.89 28 140460 2960 42477887
Hepatorenal failure 11.08 10.89 12 140476 621 42480226
Clonus 11.07 10.89 31 140457 3489 42477358
Squamous cell carcinoma 11.05 10.89 16 140472 12966 42467881
Juvenile myoclonic epilepsy 11.04 10.89 5 140483 59 42480788
Mental impairment 11.03 10.89 74 140414 12243 42468604
Cataplexy 11.02 10.89 10 140478 417 42480430
Drug abuser 11.01 10.89 31 140457 3500 42477347
Pulmonary embolism 11.00 10.89 305 140183 119307 42361540
Neck pain 10.96 10.89 149 140339 29865 42450982
Tachycardia 10.93 10.89 422 140066 100665 42380182
Oedema 10.92 10.89 114 140374 51887 42428960
Neonatal seizure 10.92 10.89 11 140477 523 42480324

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intentional overdose 2226.28 9.76 2426 353044 130075 110103754
Serotonin syndrome 2182.39 9.76 1684 353786 57469 110176360
Intentional self-injury 2173.21 9.76 1406 354064 36023 110197806
Suicide attempt 1824.00 9.76 1943 353527 101451 110132378
Suicidal ideation 1736.57 9.76 1810 353660 92127 110141702
Drug interaction 1390.79 9.76 4138 351332 496045 109737784
Drug abuse 1334.81 9.76 2193 353277 175218 110058611
Completed suicide 1194.56 9.76 2497 352973 239884 109993945
Toxicity to various agents 924.49 9.76 3514 351956 477041 109756788
Anxiety 770.50 9.76 2650 352820 342428 109891401
Agitation 757.75 9.76 1328 354142 111723 110122106
Tremor 701.64 9.76 1816 353654 200416 110033413
Pemphigus 660.72 9.76 5 355465 214565 110019264
Hand deformity 646.30 9.76 11 355459 218495 110015334
Abnormal dreams 644.66 9.76 440 355030 12340 110221489
Depression 610.51 9.76 2322 353148 315013 109918816
Psychotic disorder 541.95 9.76 741 354729 50196 110183633
Sopor 537.56 9.76 625 354845 35921 110197908
Somnolence 511.08 9.76 2101 353369 295348 109938481
Overdose 509.63 9.76 1782 353688 232012 110001817
Pericarditis 507.11 9.76 56 355414 219058 110014771
Systemic lupus erythematosus 506.04 9.76 101 355369 254237 109979592
Synovitis 499.24 9.76 132 355338 273960 109959869
Akathisia 499.17 9.76 425 355045 16688 110217141
Glossodynia 498.28 9.76 63 355407 221941 110011888
Paranoia 482.55 9.76 469 355001 21905 110211924
Duodenal ulcer perforation 471.54 9.76 24 355446 177676 110056153
Folliculitis 470.56 9.76 15 355455 167638 110066191
Helicobacter infection 443.17 9.76 38 355432 181839 110051990
Aggression 424.72 9.76 717 354753 58493 110175336
Withdrawal syndrome 411.15 9.76 506 354964 30874 110202955
Infusion related reaction 395.50 9.76 385 355085 380777 109853052
Hyponatraemia 389.24 9.76 1557 353913 216096 110017733
Dyskinesia 387.75 9.76 637 354833 50809 110183020
Nightmare 385.97 9.76 547 354923 38316 110195513
Stomatitis 384.47 9.76 194 355276 270048 109963781
Joint swelling 379.95 9.76 521 354949 442324 109791505
Muscle injury 376.82 9.76 18 355452 140789 110093040
Rheumatic fever 371.86 9.76 4 355466 122575 110111254
Neuroleptic malignant syndrome 355.54 9.76 491 354979 33568 110200261
Wound 355.53 9.76 154 355316 234283 109999546
Hallucination, auditory 349.63 9.76 428 355042 25969 110207860
Dystonia 339.52 9.76 417 355053 25388 110208441
Poisoning deliberate 334.39 9.76 418 355052 25913 110207916
Hypomania 334.02 9.76 271 355199 9939 110223890
Psoriatic arthropathy 326.95 9.76 112 355358 196649 110037180
Mania 326.67 9.76 368 355102 20428 110213401
Arthropathy 322.56 9.76 270 355200 287252 109946577
Impaired healing 321.68 9.76 115 355355 196602 110037227
Hallucination 320.23 9.76 880 354590 100552 110133277
Parkinsonism 313.90 9.76 372 355098 21815 110212014
Restlessness 312.78 9.76 610 354860 55649 110178180
Irritable bowel syndrome 312.70 9.76 72 355398 164143 110069686
Electrocardiogram QT prolonged 312.46 9.76 913 354557 108047 110125782
Abnormal behaviour 303.16 9.76 490 354980 38549 110195280
Sleep disorder due to general medical condition, insomnia type 301.74 9.76 8 355462 105635 110128194
Hallucination, visual 300.63 9.76 492 354978 39113 110194716
Pyrexia 297.97 9.76 1683 353787 896582 109337247
C-reactive protein abnormal 295.38 9.76 35 355435 129660 110104169
Irritability 295.04 9.76 542 354928 47267 110186562
Febrile neutropenia 292.94 9.76 352 355118 316415 109917414
Facet joint syndrome 289.95 9.76 4 355466 96824 110137005
Extrapyramidal disorder 287.68 9.76 407 355063 28460 110205369
Contraindicated product administered 281.09 9.76 231 355239 248036 109985793
Mydriasis 278.59 9.76 350 355120 21807 110212022
Alopecia 265.34 9.76 479 354991 364274 109869555
Blister 264.38 9.76 206 355264 227170 110006659
Nasopharyngitis 263.31 9.76 545 354925 393816 109840013
Psychomotor skills impaired 260.22 9.76 201 355269 6857 110226972
Drug withdrawal syndrome 259.95 9.76 451 355019 37603 110196226
Lip dry 257.81 9.76 16 355454 100067 110133762
Lower respiratory tract infection 253.83 9.76 244 355226 242862 109990967
Treatment failure 253.21 9.76 311 355159 276923 109956906
Swelling 251.77 9.76 465 355005 350576 109883253
General physical health deterioration 250.53 9.76 629 354841 424666 109809163
Bursitis 249.27 9.76 56 355414 129862 110103967
Bruxism 247.28 9.76 170 355300 4824 110229005
Seizure 246.17 9.76 1379 354091 219806 110014023
Panic attack 243.71 9.76 377 355093 28563 110205266
Fibromyalgia 242.54 9.76 123 355347 170786 110063043
Schizophrenia 238.92 9.76 322 355148 21504 110212325
Psychomotor hyperactivity 237.14 9.76 309 355161 19968 110213861
Depressed mood 236.79 9.76 571 354899 60238 110173591
Ill-defined disorder 234.66 9.76 105 355365 156748 110077081
Rheumatoid arthritis 230.16 9.76 380 355090 299233 109934596
Loss of consciousness 222.49 9.76 1230 354240 195076 110038753
Joint range of motion decreased 221.09 9.76 59 355411 121773 110112056
Colitis microscopic 220.65 9.76 243 355227 13151 110220678
Tic 216.97 9.76 137 355333 3356 110230473
Disorientation 213.05 9.76 603 354867 70068 110163761
Muscle rigidity 212.16 9.76 320 355150 23711 110210118
Peripheral venous disease 209.24 9.76 16 355454 84101 110149728
Sinusitis 208.30 9.76 398 355072 296290 109937539
Anger 207.42 9.76 280 355190 18727 110215102
Hepatic enzyme increased 205.36 9.76 454 355016 320438 109913391
Depression suicidal 203.68 9.76 149 355321 4675 110229154
Myelosuppression 201.65 9.76 31 355439 94309 110139520
Musculoskeletal pain 201.36 9.76 175 355295 182848 110050981
Therapeutic product effect decreased 199.86 9.76 297 355173 244019 109989810
Rash 199.28 9.76 1685 353785 819279 109414550
Drug intolerance 199.23 9.76 656 354814 405856 109827973
Sexual dysfunction 197.56 9.76 186 355284 8344 110225485
Loss of libido 197.41 9.76 124 355346 3009 110230820
Inappropriate antidiuretic hormone secretion 196.67 9.76 374 355096 33477 110200352
Hyperhidrosis 195.44 9.76 1148 354322 186150 110047679
Tearfulness 194.18 9.76 173 355297 7222 110226607
Disturbance in attention 193.78 9.76 536 354934 61459 110172370
Myoclonus 193.48 9.76 366 355104 32632 110201197
Tardive dyskinesia 192.63 9.76 228 355242 13351 110220478
Wound infection 192.40 9.76 38 355432 96427 110137402
Type 2 diabetes mellitus 189.53 9.76 174 355296 177058 110056771
Arthralgia 186.12 9.76 1607 353863 778025 109455804
Peripheral swelling 185.82 9.76 670 354800 403364 109830465
Feeling abnormal 184.29 9.76 1101 354369 179610 110054219
Homicidal ideation 183.21 9.76 125 355345 3502 110230327
Depressive symptom 182.60 9.76 177 355293 8237 110225592
Off label use 180.42 9.76 3572 351898 1496613 108737216
Psychiatric decompensation 180.15 9.76 149 355321 5616 110228213
Delusion 180.14 9.76 295 355175 23460 110210369
Infection 179.88 9.76 581 354889 361619 109872210
Grip strength decreased 179.21 9.76 23 355447 80151 110153678
Confusional state 178.45 9.76 2295 353175 466385 109767444
Abdominal discomfort 176.60 9.76 660 354810 393198 109840631
Psychomotor retardation 171.14 9.76 165 355305 7627 110226202
Hyperreflexia 170.13 9.76 180 355290 9305 110224524
Malignant neoplasm progression 169.94 9.76 186 355284 174381 110059448
Sedation 168.22 9.76 550 354920 69133 110164696
Mobility decreased 167.93 9.76 317 355153 237105 109996724
Mood swings 167.22 9.76 279 355191 22533 110211296
Bradykinesia 166.20 9.76 189 355281 10599 110223230
Obsessive-compulsive disorder 165.99 9.76 157 355313 7084 110226745
Liver injury 165.23 9.76 144 355326 150269 110083560
Bradyphrenia 163.20 9.76 195 355275 11533 110222296
Inflammation 162.85 9.76 230 355240 193008 110040821
Rheumatoid factor positive 159.76 9.76 114 355356 131526 110102303
Fall 158.35 9.76 2772 352698 600710 109633119
Autoimmune disorder 155.92 9.76 15 355455 65468 110168361
Treatment noncompliance 155.05 9.76 552 354918 72438 110161391
Lung disorder 154.02 9.76 212 355258 179835 110053994
Anorgasmia 153.55 9.76 84 355386 1562 110232267
Hyperprolactinaemia 153.48 9.76 144 355326 6431 110227398
Discomfort 153.32 9.76 285 355185 214422 110019407
Catatonia 152.52 9.76 185 355285 11115 110222714
Insomnia 151.52 9.76 1799 353671 358791 109875038
Thinking abnormal 150.16 9.76 213 355257 14927 110218902
Gastrointestinal disorder 148.52 9.76 350 355120 241602 109992227
Erectile dysfunction 148.29 9.76 236 355234 18320 110215509
Self-injurious ideation 147.77 9.76 118 355352 4228 110229601
Sciatica 144.35 9.76 58 355412 92341 110141488
C-reactive protein increased 143.77 9.76 303 355167 217616 110016213
Liver disorder 143.55 9.76 147 355323 142096 110091733
Mental disorder 143.30 9.76 357 355113 38434 110195395
Emotional distress 142.39 9.76 390 355080 44457 110189372
Hallucinations, mixed 141.97 9.76 157 355313 8536 110225293
Apathy 141.59 9.76 215 355255 16024 110217805
Blood prolactin increased 140.95 9.76 118 355352 4524 110229305
Osteoarthritis 140.75 9.76 231 355239 182392 110051437
Complication of device insertion 136.43 9.76 155 355315 8683 110225146
Suicidal behaviour 136.42 9.76 103 355367 3394 110230435
Major depression 135.47 9.76 169 355301 10452 110223377
Bone erosion 134.36 9.76 3 355467 46368 110187461
Crying 134.14 9.76 271 355199 25357 110208472
Disease progression 133.63 9.76 374 355096 243660 109990169
Intentional product use issue 132.03 9.76 385 355085 247521 109986308
Libido decreased 129.07 9.76 125 355345 5810 110228019
Social avoidant behaviour 128.05 9.76 119 355351 5250 110228579
Respiratory arrest 127.35 9.76 445 355025 57854 110175975
Amenorrhoea 126.01 9.76 152 355318 9079 110224750
Hypercholesterolaemia 124.96 9.76 68 355402 90769 110143060
Neutropenia 124.80 9.76 700 354770 373920 109859909
Priapism 124.76 9.76 122 355348 5739 110228090
Homicide 124.55 9.76 64 355406 1042 110232787
Coma 124.55 9.76 725 354745 117144 110116685
Dislocation of vertebra 122.32 9.76 4 355466 43717 110190112
Blood cholesterol increased 121.82 9.76 257 355213 184528 110049301
Cardiac arrest 119.61 9.76 1059 354411 195694 110038135
Poisoning 119.46 9.76 279 355191 28826 110205003
Anhedonia 118.89 9.76 193 355277 15235 110218594
Speech disorder 118.48 9.76 451 355019 61118 110172711
Product use issue 118.17 9.76 557 354913 311138 109922691
Thrombocytopenia 117.79 9.76 649 354821 348236 109885593
Adjustment disorder with depressed mood 116.14 9.76 6 355464 43877 110189952
Persistent genital arousal disorder 115.29 9.76 52 355418 624 110233205
Intrusive thoughts 115.20 9.76 53 355417 668 110233161
Galactorrhoea 114.69 9.76 100 355370 4055 110229774
Cytomegalovirus infection 113.85 9.76 19 355451 54425 110179404
Urticaria 113.84 9.76 582 354888 318275 109915554
Nail disorder 113.09 9.76 24 355446 57911 110175918
Onychomadesis 112.68 9.76 9 355461 45654 110188175
Tachyphrenia 111.49 9.76 78 355392 2278 110231551
Trismus 110.96 9.76 121 355349 6475 110227354
Septic shock 107.30 9.76 215 355255 157313 110076516
Swollen tongue 107.10 9.76 431 355039 59931 110173898
Hypersensitivity 107.08 9.76 809 354661 403189 109830640
Dizziness 105.77 9.76 2965 352505 695228 109538601
Renal impairment 105.24 9.76 286 355184 188159 110045670
Oromandibular dystonia 104.92 9.76 59 355411 1160 110232669
Live birth 104.71 9.76 46 355424 69438 110164391
Emotional disorder 104.51 9.76 187 355283 15973 110217856
Restless legs syndrome 104.30 9.76 239 355231 24387 110209442
Product substitution issue 103.46 9.76 229 355241 22832 110210997
Salivary hypersecretion 103.08 9.76 194 355276 17227 110216602
Muscle twitching 100.74 9.76 266 355204 29669 110204160
Anaemia 100.38 9.76 1200 354270 545886 109687943
Clonus 99.09 9.76 131 355339 8585 110225244
Bipolar disorder 98.76 9.76 133 355337 8874 110224955
Neuropathy peripheral 98.69 9.76 274 355196 179003 110054826
Oedema 98.57 9.76 345 355125 209631 110024198
Dysarthria 97.85 9.76 531 354939 83590 110150239
Pneumonia 97.34 9.76 2113 353357 874601 109359228
Pancytopenia 96.66 9.76 347 355123 209266 110024563
Affective disorder 95.43 9.76 147 355323 11094 110222735
Euphoric mood 94.74 9.76 129 355341 8698 110225131
Generalised tonic-clonic seizure 93.50 9.76 386 355084 54294 110179535
Mental impairment 91.80 9.76 216 355254 22423 110211406
Lower limb fracture 91.74 9.76 65 355405 75283 110158546
Hip arthroplasty 90.56 9.76 33 355437 55780 110178049
Drug dependence 89.41 9.76 358 355112 49662 110184167
Blood creatine phosphokinase increased 88.89 9.76 467 355003 72610 110161219
Rhabdomyolysis 87.61 9.76 675 354795 119726 110114103
Cardio-respiratory arrest 87.42 9.76 655 354815 115181 110118648
Knee arthroplasty 87.34 9.76 50 355420 64898 110168931
Flat affect 87.28 9.76 69 355401 2436 110231393
Psychotic symptom 87.03 9.76 83 355387 3784 110230045
Urinary retention 86.62 9.76 448 355022 69235 110164594
Tachycardia 86.57 9.76 1111 354359 225534 110008295
Vertigo 86.42 9.76 526 354944 86344 110147485
Syncope 86.09 9.76 1013 354457 201523 110032306
Impulsive behaviour 85.95 9.76 77 355393 3238 110230591
Mucosal inflammation 85.46 9.76 110 355360 96031 110137798
Antipsychotic drug level increased 85.31 9.76 109 355361 6906 110226923
Reversible cerebral vasoconstriction syndrome 84.77 9.76 90 355380 4671 110229158
Cytokine release syndrome 83.84 9.76 62 355408 70244 110163585
Swelling face 83.75 9.76 546 354924 91775 110142054
Gait inability 83.07 9.76 198 355272 136178 110097651
X-ray abnormal 82.66 9.76 12 355458 38105 110195724
Gestational diabetes 82.38 9.76 110 355360 7279 110226550
Intentional product misuse 82.12 9.76 718 354752 132186 110101643
Maculopathy 81.84 9.76 72 355398 2955 110230874
C-reactive protein 80.73 9.76 4 355466 30327 110203502
Obsessive thoughts 80.52 9.76 51 355419 1256 110232573
Activation syndrome 80.32 9.76 34 355436 346 110233483
Osteoporosis 80.31 9.76 97 355373 87055 110146774
Acute kidney injury 78.30 9.76 1505 353965 633925 109599904
Finger deformity 77.68 9.76 8 355462 33084 110200745
Infarction 77.28 9.76 90 355380 5179 110228650
Negative thoughts 76.74 9.76 54 355416 1592 110232237
Tension 76.59 9.76 88 355382 4990 110228839
Taste disorder 74.99 9.76 60 355410 65327 110168502
Coeliac disease 74.49 9.76 23 355447 43164 110190665
Lethargy 73.95 9.76 535 354935 93041 110140788
Alcoholism 73.06 9.76 74 355396 3633 110230196
Genital hypoaesthesia 72.66 9.76 27 355443 188 110233641
Sepsis 71.66 9.76 689 354781 326657 109907172
Total lung capacity increased 71.13 9.76 85 355385 5027 110228802
Balance disorder 71.13 9.76 628 354842 115932 110117897
Mood altered 70.98 9.76 189 355281 21186 110212643
Dystonic tremor 70.71 9.76 31 355439 346 110233483
Depressed level of consciousness 70.63 9.76 609 354861 111669 110122160
Yawning 70.38 9.76 50 355420 1497 110232332
Dissociation 70.30 9.76 119 355351 9723 110224106
Musculoskeletal stiffness 69.14 9.76 571 354899 279251 109954578
Drug ineffective 69.11 9.76 4094 351376 1516446 108717383
Dermatitis atopic 68.42 9.76 209 355261 25332 110208497
Pleural effusion 68.23 9.76 316 355154 177393 110056436
Lupus-like syndrome 68.10 9.76 23 355447 40769 110193060
Unresponsive to stimuli 67.13 9.76 392 355078 63398 110170431
Cardiac failure 66.62 9.76 343 355127 187283 110046546
Hypersomnia 65.49 9.76 219 355251 27842 110205987
Torticollis 64.77 9.76 65 355405 3156 110230673
Foaming at mouth 63.40 9.76 55 355415 2215 110231614
Hepatic function abnormal 63.29 9.76 119 355351 89176 110144653
Pain 63.08 9.76 2471 352999 952484 109281345
Eosinophilic pneumonia acute 62.66 9.76 48 355422 1617 110232212
Hypoaesthesia 62.34 9.76 677 354793 313546 109920283
Exostosis 62.34 9.76 35 355435 45921 110187908
Disturbance in sexual arousal 62.24 9.76 29 355441 377 110233452
Pneumocystis jirovecii pneumonia 61.74 9.76 30 355440 42705 110191124
Platelet count decreased 61.69 9.76 460 355010 229983 110003846
Suspected suicide 61.61 9.76 145 355325 15054 110218775
Bronchopulmonary aspergillosis 61.17 9.76 11 355459 29852 110203977
Asthma-chronic obstructive pulmonary disease overlap syndrome 61.07 9.76 88 355382 6256 110227573
Neutrophil count decreased 60.65 9.76 193 355277 120748 110113081
Headache 60.65 9.76 3440 352030 878937 109354892
Fear 60.46 9.76 188 355282 23005 110210824
Movement disorder 59.90 9.76 254 355216 36150 110197679
Head titubation 59.76 9.76 43 355427 1314 110232515
Haemophagocytic lymphohistiocytosis 59.73 9.76 14 355456 31545 110202284
Mental status changes 59.45 9.76 434 355036 75688 110158141
Thrombotic microangiopathy 59.14 9.76 11 355459 29138 110204691
Bipolar I disorder 59.13 9.76 53 355417 2230 110231599
Dysphoria 58.74 9.76 87 355383 6341 110227488
Liver function test increased 58.47 9.76 123 355347 88425 110145404
Cognitive disorder 57.86 9.76 480 354990 87031 110146798
Sensation of foreign body 57.73 9.76 97 355373 7878 110225951
Mitochondrial myopathy acquired 57.46 9.76 16 355454 35 110233794
Pregnancy with implant contraceptive 57.39 9.76 53 355417 2319 110231510
Cogwheel rigidity 57.32 9.76 65 355405 3633 110230196
Product label confusion 57.29 9.76 4 355466 22673 110211156
Lipid metabolism disorder 57.23 9.76 32 355438 622 110233207
Depersonalisation/derealisation disorder 57.22 9.76 51 355419 2130 110231699
Maternal exposure during pregnancy 56.83 9.76 534 354936 254349 109979480
Prostate cancer 56.58 9.76 25 355445 37616 110196213
Adrenal insufficiency 56.48 9.76 33 355437 42357 110191472
Abulia 56.44 9.76 41 355429 1272 110232557
Nausea 55.98 9.76 4653 350817 1231037 109002792
Device expulsion 55.94 9.76 222 355248 30669 110203160
Eye movement disorder 55.91 9.76 107 355363 9621 110224208
Arthritis 55.28 9.76 314 355156 167272 110066557
Therapy non-responder 55.04 9.76 289 355181 157018 110076811
Resting tremor 54.81 9.76 45 355425 1678 110232151
Upper gastrointestinal haemorrhage 54.77 9.76 311 355159 49785 110184044
Somnambulism 54.71 9.76 84 355386 6321 110227508
Persecutory delusion 54.43 9.76 83 355387 6208 110227621
Derealisation 53.74 9.76 49 355421 2109 110231720
Drug screen positive 53.26 9.76 83 355387 6327 110227502
Disorganised speech 52.81 9.76 59 355411 3244 110230585
Urinary incontinence 52.70 9.76 301 355169 48286 110185543
Jaundice cholestatic 52.44 9.76 133 355337 14475 110219354
Inborn error of lipid metabolism 52.18 9.76 11 355459 0 110233829
Persistent depressive disorder 52.14 9.76 41 355429 1436 110232393
Metabolic syndrome 51.92 9.76 58 355412 3189 110230640
Food interaction 51.91 9.76 48 355422 2104 110231725
Cholecystitis chronic 51.56 9.76 102 355368 9398 110224431
Tubulointerstitial nephritis 51.53 9.76 59 355411 54225 110179604
Product complaint 49.94 9.76 127 355343 13845 110219984
Frequent bowel movements 49.84 9.76 96 355374 71294 110162535
Ideas of reference 49.79 9.76 20 355450 176 110233653
Pain in extremity 49.40 9.76 1190 354280 485928 109747901
Hypertonia 48.98 9.76 93 355377 8313 110225516
Device placement issue 48.69 9.76 43 355427 1774 110232055
Head discomfort 48.60 9.76 153 355317 18847 110214982
Phospholipidosis 48.43 9.76 23 355447 313 110233516
Delirium 48.24 9.76 654 354816 134371 110099458
Conversion disorder 47.97 9.76 48 355422 2322 110231507
Dysphemia 47.95 9.76 62 355408 3975 110229854
Uterine perforation 47.93 9.76 82 355388 6758 110227071
Back injury 47.79 9.76 49 355421 47350 110186479
Confabulation 46.98 9.76 26 355444 495 110233334
Neurological symptom 46.85 9.76 133 355337 15475 110218354
Heavy menstrual bleeding 46.75 9.76 137 355333 16228 110217601
Arteriosclerosis coronary artery 46.68 9.76 182 355288 24936 110208893
Ascites 46.61 9.76 148 355322 92660 110141169
Bone marrow failure 46.61 9.76 71 355399 57777 110176052
Muscle tightness 46.48 9.76 128 355342 14634 110219195
Obesity 46.25 9.76 197 355273 113154 110120675
Onychomycosis 45.91 9.76 34 355436 38497 110195332
Cholelithiasis 45.81 9.76 355 355115 63067 110170762
Impulse-control disorder 45.45 9.76 45 355425 2149 110231680
Tumour lysis syndrome 45.45 9.76 21 355449 30780 110203049
Ejaculation failure 45.28 9.76 23 355447 365 110233464
Flashback 45.27 9.76 24 355446 418 110233411
Mite allergy 45.26 9.76 73 355397 5730 110228099
Multiple organ dysfunction syndrome 44.93 9.76 294 355176 151416 110082413
Embedded device 44.90 9.76 60 355410 3973 110229856
Posture abnormal 44.84 9.76 63 355407 4375 110229454
Behaviour disorder 44.64 9.76 97 355373 9550 110224279
Hepatic cirrhosis 44.59 9.76 94 355376 67532 110166297
Nervousness 44.47 9.76 235 355235 36616 110197213
Self-destructive behaviour 44.46 9.76 30 355440 825 110233004
Ear infection 44.10 9.76 84 355386 62648 110171181
Formication 43.99 9.76 71 355399 5577 110228252
Chorea 43.72 9.76 53 355417 3182 110230647
Presyncope 43.64 9.76 288 355182 48599 110185230
Emotional poverty 43.63 9.76 32 355438 1008 110232821
Social anxiety disorder 43.44 9.76 31 355439 935 110232894
Burning mouth syndrome 43.03 9.76 27 355443 654 110233175
Drug-induced liver injury 42.89 9.76 219 355251 119848 110113981
Pulmonary vasculitis 42.53 9.76 76 355394 6484 110227345
Cytomegalovirus viraemia 42.47 9.76 4 355466 17760 110216069
Abnormal weight gain 42.42 9.76 55 355415 3536 110230293
Acute psychosis 42.03 9.76 65 355405 4922 110228907
Blepharospasm 41.66 9.76 70 355400 54781 110179048
Hyperphagia 41.58 9.76 54 355416 3477 110230352
Night sweats 41.55 9.76 256 355214 133727 110100102
Laryngitis 41.46 9.76 45 355425 42366 110191463
Cardiac murmur 41.42 9.76 173 355297 24455 110209374
Drug level increased 41.32 9.76 279 355191 47440 110186389
White blood cell count decreased 41.28 9.76 505 354965 228885 110004944
Vision blurred 40.92 9.76 612 354858 128410 110105419
Neuritis 40.83 9.76 80 355390 7319 110226510
Haematotoxicity 40.60 9.76 9 355461 21073 110212756
Porphyria acute 40.52 9.76 6 355464 18774 110215055
Self esteem decreased 40.42 9.76 31 355439 1046 110232783
Drowning 40.25 9.76 29 355441 888 110232941
Generalised anxiety disorder 39.98 9.76 47 355423 2732 110231097
Injury 39.66 9.76 371 355099 176894 110056935
Psychiatric symptom 39.66 9.76 90 355380 9123 110224706
Cycloplegia 39.39 9.76 9 355461 4 110233825
Immunodeficiency 39.32 9.76 40 355430 38798 110195031
Dyspnoea 39.25 9.76 3045 352425 1103827 109130002
Cerebral vasoconstriction 39.18 9.76 35 355435 1466 110232363
Violence-related symptom 39.09 9.76 29 355441 930 110232899
Transplant rejection 39.06 9.76 15 355455 24552 110209277
Pruritus 38.91 9.76 1502 353968 580058 109653771
Road traffic accident 38.87 9.76 195 355275 107203 110126626
Head injury 38.75 9.76 254 355216 42763 110191066
Physical assault 38.66 9.76 36 355434 1592 110232237
Hyponatraemic seizure 38.59 9.76 26 355444 713 110233116
Drug dose titration not performed 38.54 9.76 30 355440 1035 110232794
Pseudodementia 38.35 9.76 11 355459 28 110233801
Enuresis 38.24 9.76 56 355414 4040 110229789
Miosis 38.22 9.76 156 355314 21827 110212002
Substance abuse 38.19 9.76 107 355363 12356 110221473
Loss of personal independence in daily activities 38.08 9.76 686 354784 149334 110084495
Anaphylactic shock 38.04 9.76 67 355403 51479 110182350
Disseminated intravascular coagulation 37.98 9.76 46 355424 41240 110192589
Poverty of thought content 37.79 9.76 13 355457 70 110233759
Orgasm abnormal 37.69 9.76 17 355453 204 110233625
Myelodysplastic syndrome 37.50 9.76 39 355431 37445 110196384
Incoherent 37.49 9.76 83 355387 8275 110225554
Device dislocation 37.45 9.76 201 355269 31503 110202326
Infusion site reaction 37.35 9.76 6 355464 17676 110216153
Mutism 37.27 9.76 48 355422 3065 110230764
Nephropathy toxic 37.16 9.76 21 355449 27457 110206372
Hypertension 37.12 9.76 1304 354166 508780 109725049
Conjunctivitis allergic 37.12 9.76 74 355396 6857 110226972
Aspergillus infection 36.98 9.76 18 355452 25598 110208231
Apraxia 36.89 9.76 51 355419 3489 110230340
Logorrhoea 36.83 9.76 61 355409 4896 110228933
Rabbit syndrome 36.70 9.76 20 355450 369 110233460
Grandiosity 36.69 9.76 23 355447 556 110233273
Alcohol interaction 36.68 9.76 52 355418 3642 110230187
Cytopenia 36.63 9.76 26 355444 30090 110203739
Foetal exposure during pregnancy 36.50 9.76 77 355393 7428 110226401
Foreign body in reproductive tract 36.48 9.76 28 355442 946 110232883
Polydipsia 36.37 9.76 78 355392 7610 110226219
Panic disorder 36.27 9.76 50 355420 3411 110230418
Libido disorder 36.25 9.76 19 355451 323 110233506
Total lung capacity abnormal 36.22 9.76 58 355412 4525 110229304
Prescription drug used without a prescription 36.05 9.76 64 355406 5432 110228397
Joint dislocation 36.02 9.76 34 355436 34156 110199673
Attention deficit hyperactivity disorder 35.72 9.76 57 355413 4434 110229395
Premature ejaculation 35.61 9.76 12 355458 60 110233769
Negativism 35.44 9.76 27 355443 902 110232927
Energy increased 35.42 9.76 51 355419 3623 110230206
Wrong patient 35.31 9.76 33 355437 1466 110232363
Pseudomonas infection 35.28 9.76 23 355447 27830 110205999
Vomiting 35.25 9.76 3391 352079 907284 109326545
Heat stroke 35.20 9.76 37 355433 1898 110231931
Asphyxia 35.02 9.76 113 355357 14102 110219727
Mycotic allergy 34.85 9.76 66 355404 5888 110227941
Spirometry abnormal 34.77 9.76 63 355407 5434 110228395
Muscle contracture 34.73 9.76 44 355426 2764 110231065
Palpitations 34.61 9.76 711 354759 158501 110075328
Complication of device removal 34.52 9.76 57 355413 4563 110229266
Colitis ulcerative 34.37 9.76 130 355340 77233 110156596
Palmar-plantar erythrodysaesthesia syndrome 34.37 9.76 49 355421 40976 110192853
Sinus tachycardia 34.35 9.76 253 355217 44240 110189589
Photophobia 34.35 9.76 169 355301 25602 110208227
Metabolic myopathy 34.29 9.76 14 355456 129 110233700
Dementia with Lewy bodies 34.25 9.76 28 355442 1038 110232791
Rhinitis allergic 34.24 9.76 131 355339 17791 110216038
Increased appetite 34.16 9.76 116 355354 14861 110218968
Cold sweat 34.16 9.76 151 355319 21880 110211949
Somatic symptom disorder of pregnancy 33.99 9.76 13 355457 99 110233730
Chronic obstructive pulmonary disease 33.93 9.76 516 354954 108642 110125187
Somatic symptom disorder 33.65 9.76 46 355424 3113 110230716
Inappropriate affect 33.64 9.76 34 355436 1665 110232164
Cardiogenic shock 33.53 9.76 85 355385 57253 110176576
Sleep-related eating disorder 33.35 9.76 26 355444 899 110232930
Long-chain acyl-coenzyme A dehydrogenase deficiency 33.20 9.76 7 355463 0 110233829
Action tremor 33.10 9.76 20 355450 452 110233377
Therapeutic response unexpected 32.96 9.76 158 355312 23685 110210144
Multiple sclerosis relapse 32.90 9.76 275 355195 49965 110183864
Semen discolouration 32.86 9.76 9 355461 18 110233811
Unintended pregnancy 32.85 9.76 57 355413 4751 110229078
Rash maculo-papular 32.80 9.76 125 355345 74097 110159732
Pressure of speech 32.69 9.76 30 355440 1302 110232527
Post-traumatic stress disorder 32.45 9.76 68 355402 6528 110227301
Disinhibition 32.43 9.76 45 355425 3089 110230740
Intermenstrual bleeding 32.40 9.76 70 355400 6864 110226965
Interstitial lung disease 32.30 9.76 289 355181 139045 110094784
Pleurothotonus 32.26 9.76 40 355430 2458 110231371
Hyponatraemic syndrome 32.26 9.76 24 355446 773 110233056
Overweight 32.23 9.76 67 355403 6397 110227432
Communication disorder 32.19 9.76 58 355412 4981 110228848
Schizoaffective disorder bipolar type 32.17 9.76 17 355453 294 110233535
Incontinence 32.11 9.76 122 355348 16513 110217316
Cataract 31.90 9.76 139 355331 79346 110154483
Negative symptoms in schizophrenia 31.53 9.76 15 355455 205 110233624
Torsade de pointes 31.41 9.76 150 355320 22450 110211379
Oral candidiasis 31.41 9.76 60 355410 44700 110189129
Feeling of despair 31.31 9.76 49 355421 3749 110230080
Brain injury 31.29 9.76 105 355365 13371 110220458
Nystagmus 31.26 9.76 95 355375 11482 110222347
Borderline personality disorder 31.17 9.76 27 355443 1085 110232744
Retroplacental haematoma 31.09 9.76 13 355457 128 110233701
Urine sodium decreased 31.00 9.76 16 355454 263 110233566
Pancreatic fibrosis 30.97 9.76 12 355458 95 110233734
Hyperthermia 30.89 9.76 143 355327 21129 110212700
Dust allergy 30.86 9.76 63 355407 5938 110227891
Psychogenic seizure 30.77 9.76 38 355432 2326 110231503
Decreased interest 30.72 9.76 56 355414 4852 110228977
Febrile bone marrow aplasia 30.67 9.76 9 355461 17456 110216373
Adverse event 30.65 9.76 214 355256 108595 110125234
Joint stiffness 30.52 9.76 112 355358 67131 110166698
Male orgasmic disorder 30.44 9.76 11 355459 70 110233759
Product tampering 30.29 9.76 19 355451 460 110233369
Platelet aggregation abnormal 30.18 9.76 10 355460 47 110233782
Victim of chemical submission 30.17 9.76 24 355446 855 110232974
Walking aid user 30.04 9.76 22 355448 25053 110208776
Maternal exposure timing unspecified 29.98 9.76 15 355455 20998 110212831
Diplopia 29.97 9.76 234 355236 41660 110192169
Prostatic pain 29.96 9.76 16 355454 283 110233546
Blood pressure fluctuation 29.94 9.76 131 355339 74693 110159136
Herpes zoster 29.63 9.76 215 355255 108164 110125665
Ejaculation delayed 29.58 9.76 14 355456 189 110233640
Petit mal epilepsy 29.51 9.76 71 355399 7476 110226353
Muscle contractions involuntary 29.47 9.76 52 355418 4392 110229437
Polyarthritis 29.45 9.76 12 355458 18951 110214878
Haematemesis 29.38 9.76 305 355165 58803 110175026
Blood test abnormal 29.38 9.76 29 355441 28525 110205304
Enthesopathy 29.33 9.76 3 355467 12475 110221354
Morbid thoughts 29.23 9.76 24 355446 895 110232934
Sarcoidosis 29.20 9.76 98 355372 12481 110221348
Postmortem blood drug level increased 29.07 9.76 27 355443 1190 110232639
Graft versus host disease 29.05 9.76 12 355458 18794 110215035
Foot deformity 29.03 9.76 71 355399 48409 110185420
Feelings of worthlessness 29.01 9.76 20 355450 570 110233259
Urinary hesitation 28.97 9.76 53 355417 4605 110229224
Breast pain 28.84 9.76 84 355386 9916 110223913
Maternal exposure during breast feeding 28.64 9.76 50 355420 4188 110229641
Periodic limb movement disorder 28.61 9.76 18 355452 438 110233391
Dysgraphia 28.59 9.76 53 355417 4652 110229177
Cystitis haemorrhagic 28.53 9.76 3 355467 12206 110221623
Parasomnia 28.52 9.76 22 355448 749 110233080
Idiopathic intracranial hypertension 28.51 9.76 48 355422 3904 110229925
Reflexes abnormal 28.50 9.76 25 355445 1022 110232807
Neoplasm progression 28.40 9.76 109 355361 64486 110169343
Myasthenia gravis 28.30 9.76 17 355453 21494 110212335
Blood pressure systolic abnormal 28.25 9.76 23 355447 24827 110209002
Sensory disturbance 28.20 9.76 121 355349 17308 110216521
Leukopenia 28.13 9.76 324 355146 148467 110085362
Dermatillomania 28.08 9.76 16 355454 323 110233506
Acute graft versus host disease 28.06 9.76 4 355466 12877 110220952
Drug reaction with eosinophilia and systemic symptoms 28.05 9.76 152 355318 81943 110151886
Blood creatinine increased 28.05 9.76 416 355054 182473 110051356
Blood pressure diastolic abnormal 27.99 9.76 25 355445 25790 110208039
Respiratory disorder 27.94 9.76 126 355344 71256 110162573
Dopamine dysregulation syndrome 27.91 9.76 20 355450 607 110233222
Ataxia 27.87 9.76 179 355291 29929 110203900
Respiratory tract infection 27.68 9.76 127 355343 71490 110162339
Hypokinesia 27.59 9.76 141 355329 21685 110212144
Drug resistance 27.54 9.76 91 355379 56283 110177546
Perinatal depression 27.43 9.76 18 355452 472 110233357
Feeling drunk 27.41 9.76 57 355413 5443 110228386
Merycism 27.39 9.76 16 355454 339 110233490
Ductus arteriosus premature closure 27.26 9.76 11 355459 98 110233731
Alcohol poisoning 27.21 9.76 77 355393 8943 110224886
Hypocalcaemia 27.04 9.76 113 355357 65253 110168576
Phobia 27.01 9.76 17 355453 414 110233415
Dry mouth 26.93 9.76 466 355004 199482 110034347
Drug abuser 26.89 9.76 56 355414 5353 110228476
Prescribed overdose 26.81 9.76 168 355302 87413 110146416
Congenital nystagmus 26.79 9.76 11 355459 103 110233726
Ulcer haemorrhage 26.78 9.76 20 355450 22551 110211278
Autoscopy 26.60 9.76 11 355459 105 110233724
BK virus infection 26.47 9.76 5 355465 13101 110220728
Slow speech 26.38 9.76 43 355427 3405 110230424
Drug screen false positive 26.38 9.76 27 355443 1342 110232487
Antisocial behaviour 26.22 9.76 22 355448 846 110232983
Leukaemoid reaction 26.20 9.76 17 355453 437 110233392
Bradycardia 26.17 9.76 670 354800 154847 110078982
Pathogen resistance 26.15 9.76 12 355458 17660 110216169
Polyneuropathy 26.07 9.76 39 355431 31973 110201856
Blood phosphorus increased 25.94 9.76 10 355460 16330 110217499
Aplastic anaemia 25.81 9.76 24 355446 24284 110209545
Illness anxiety disorder 25.80 9.76 14 355456 256 110233573
Antineutrophil cytoplasmic antibody positive 25.76 9.76 53 355417 5023 110228806
Butterfly rash 25.74 9.76 33 355437 2098 110231731
Postural orthostatic tachycardia syndrome 25.71 9.76 31 355439 1851 110231978
Altered state of consciousness 25.70 9.76 291 355179 57335 110176494
Herbal interaction 25.67 9.76 19 355451 607 110233222
Binge eating 25.56 9.76 19 355451 611 110233218
Delusion of replacement 25.51 9.76 14 355456 262 110233567
Menstruation irregular 25.37 9.76 57 355413 5740 110228089
Rapid eye movement sleep behaviour disorder 25.32 9.76 19 355451 620 110233209
Rapid eye movements sleep abnormal 25.32 9.76 14 355456 266 110233563
Loose associations 25.30 9.76 10 355460 84 110233745
Judgement impaired 25.21 9.76 26 355444 1304 110232525
Panic reaction 25.18 9.76 54 355416 5268 110228561
Electrocardiogram T wave abnormal 25.00 9.76 47 355423 4170 110229659
COVID-19 24.99 9.76 598 354872 244462 109989367
Adenovirus infection 24.94 9.76 3 355467 10991 110222838
Personality change 24.91 9.76 85 355385 10917 110222912
Factor XIII deficiency 24.89 9.76 10 355460 88 110233741
Central nervous system lupus 24.84 9.76 26 355444 1327 110232502
Nasal polyps 24.82 9.76 96 355374 13104 110220725
Stiff person syndrome 24.78 9.76 19 355451 641 110233188
Caesarean section 24.78 9.76 99 355371 13718 110220111
Brugada syndrome 24.76 9.76 28 355442 1560 110232269
Renal failure 24.76 9.76 547 354923 226027 110007802
Pulmonary embolism 24.75 9.76 882 354588 213592 110020237
Suicide threat 24.60 9.76 10 355460 91 110233738
Alcohol abuse 24.47 9.76 51 355419 4878 110228951
Epstein-Barr virus infection 24.38 9.76 15 355455 18723 110215106
Mycobacterial peritonitis 24.34 9.76 13 355457 230 110233599
Amnesia 24.33 9.76 475 354995 104933 110128896
Radiologically isolated syndrome 24.32 9.76 6 355464 6 110233823
Hallucination, olfactory 24.30 9.76 18 355452 576 110233253
Tongue spasm 24.24 9.76 11 355459 134 110233695
Middle insomnia 24.23 9.76 130 355340 20372 110213457
Gastric hypomotility 24.21 9.76 14 355456 291 110233538
Aphasia 24.13 9.76 293 355177 58704 110175125
Parkinsonian gait 24.11 9.76 23 355447 1049 110232780
Upper respiratory tract infection 24.04 9.76 288 355182 131040 110102789
Gout 23.96 9.76 51 355419 36515 110197314
Differential white blood cell count abnormal 23.94 9.76 33 355437 2251 110231578
Hallucination, gustatory 23.94 9.76 9 355461 65 110233764
Hypoalbuminaemia 23.88 9.76 35 355435 28939 110204890
Creatinine renal clearance decreased 23.80 9.76 21 355449 21794 110212035
Delusional disorder, unspecified type 23.70 9.76 21 355449 870 110232959
Environmental exposure 23.70 9.76 15 355455 369 110233460
Coma scale abnormal 23.67 9.76 77 355393 9649 110224180
Screaming 23.64 9.76 50 355420 4831 110228998
Male sexual dysfunction 23.54 9.76 14 355456 307 110233522
Growth hormone-producing pituitary tumour 23.54 9.76 11 355459 144 110233685
Hypokalaemia 23.51 9.76 760 354710 181688 110052141
Mitochondrial cytopathy 23.31 9.76 15 355455 380 110233449
Alcohol use 23.27 9.76 45 355425 4077 110229752
Vanishing twin syndrome 23.26 9.76 10 355460 106 110233723
Obsessive-compulsive symptom 23.22 9.76 14 355456 315 110233514
Dysphagia 23.06 9.76 652 354818 152948 110080881
Suppressed lactation 23.03 9.76 14 355456 320 110233509
Chronic sinusitis 23.02 9.76 28 355442 25056 110208773
Motor developmental delay 23.01 9.76 13 355457 258 110233571
Metastases to bone 22.95 9.76 41 355429 31331 110202498
Amniotic fluid volume increased 22.88 9.76 11 355459 154 110233675
Hyperacusis 22.84 9.76 37 355433 2915 110230914
Granulocytopenia 22.72 9.76 91 355379 12624 110221205
Acute myeloid leukaemia 22.67 9.76 56 355414 38054 110195775
Catastrophic reaction 22.65 9.76 7 355463 25 110233804
Social problem 22.60 9.76 29 355441 1845 110231984
Immunosuppressant drug level increased 22.59 9.76 5 355465 11719 110222110
Diaphragmatic rupture 22.53 9.76 12 355458 211 110233618
Biliary dyskinesia 22.46 9.76 33 355437 2388 110231441
Pre-eclampsia 22.44 9.76 70 355400 8580 110225249
Collagen-vascular disease 22.42 9.76 9 355461 79 110233750
Mycobacterium fortuitum infection 22.38 9.76 16 355454 484 110233345
Pneumonia bacterial 22.36 9.76 31 355439 26230 110207599
Sexually inappropriate behaviour 22.35 9.76 18 355452 653 110233176
Ejaculation disorder 22.34 9.76 17 355453 567 110233262
Dyspepsia 22.33 9.76 456 355014 190509 110043320
Ectopic pregnancy 22.31 9.76 32 355438 2265 110231564
Breath sounds abnormal 22.28 9.76 149 355321 25255 110208574
Capillaritis 22.27 9.76 33 355437 2406 110231423
Myopathy 22.25 9.76 147 355323 24813 110209016
Hyperkalaemia 22.19 9.76 305 355165 135491 110098338
Feeling jittery 22.15 9.76 100 355370 14622 110219207
Bacterial infection 22.02 9.76 75 355395 45961 110187868
Oesophageal pain 21.99 9.76 50 355420 5075 110228754
Hypersexuality 21.81 9.76 29 355441 1911 110231918
Female genital tract fistula 21.81 9.76 13 355457 16506 110217323
Medication overuse headache 21.77 9.76 26 355444 1537 110232292
Prader-Willi syndrome 21.59 9.76 6 355464 13 110233816
Arteriosclerosis 21.56 9.76 145 355325 24622 110209207
Antidepressant drug level increased 21.53 9.76 17 355453 599 110233230
Tinnitus 21.52 9.76 293 355177 60247 110173582
Progressive bulbar palsy 21.49 9.76 9 355461 89 110233740
Gaze palsy 21.49 9.76 39 355431 3368 110230461
Hyperphosphataemia 21.47 9.76 13 355457 16368 110217461
Vaginal haemorrhage 21.35 9.76 146 355324 24928 110208901
Rales 21.27 9.76 29 355441 24710 110209119
Dissociative disorder 21.13 9.76 23 355447 1228 110232601
Stress 21.12 9.76 465 355005 104883 110128946
Food craving 21.09 9.76 29 355441 1974 110231855
Chronic kidney disease 21.02 9.76 151 355319 76140 110157689
Dysphonia 20.99 9.76 352 355118 75577 110158252
Forced expiratory volume decreased 20.96 9.76 91 355379 13085 110220744
Peritonitis 20.93 9.76 46 355424 32561 110201268
Morning sickness 20.93 9.76 19 355451 813 110233016
Cholestasis of pregnancy 20.92 9.76 23 355447 1242 110232587
Anticholinergic syndrome 20.91 9.76 44 355426 4236 110229593
Product quality issue 20.81 9.76 154 355316 77145 110156684
Long QT syndrome 20.73 9.76 60 355410 7058 110226771
Gallbladder cholesterolosis 20.71 9.76 17 355453 634 110233195
Body mass index increased 20.53 9.76 31 355439 2299 110231530
Gambling disorder 20.52 9.76 30 355440 2161 110231668
Macrophages increased 20.51 9.76 12 355458 255 110233574
Osteonecrosis of jaw 20.49 9.76 82 355388 47935 110185894
Underdose 20.45 9.76 120 355350 63434 110170395
Bleeding time prolonged 20.38 9.76 23 355447 1279 110232550
Central vision loss 20.36 9.76 8 355462 66 110233763
Sluggishness 20.34 9.76 62 355408 7505 110226324
Compulsive shopping 20.24 9.76 19 355451 849 110232980
Acute respiratory distress syndrome 20.17 9.76 95 355375 53103 110180726
Wrong patient received product 20.16 9.76 57 355413 6617 110227212
Hyperventilation 20.15 9.76 69 355401 8878 110224951
Hanging 20.13 9.76 11 355459 204 110233625
Agitated depression 20.09 9.76 16 355454 571 110233258
Proctitis 20.08 9.76 15 355455 16912 110216917
Transient psychosis 20.05 9.76 8 355462 69 110233760
Abortion spontaneous 20.03 9.76 183 355287 34099 110199730
Vaginal flatulence 20.01 9.76 7 355463 12137 110221692
Neurologic neglect syndrome 19.99 9.76 3 355467 9295 110224534
Proteinuria 19.96 9.76 64 355406 39954 110193875
Impaired reasoning 19.95 9.76 9 355461 108 110233721
Claustrophobia 19.94 9.76 25 355445 1554 110232275
Apallic syndrome 19.86 9.76 21 355449 1085 110232744
Hereditary angioedema 19.79 9.76 59 355411 7055 110226774
Blood uric acid increased 19.79 9.76 24 355446 21505 110212324
Intention tremor 19.76 9.76 19 355451 875 110232954
Distractibility 19.64 9.76 19 355451 882 110232947
Hemianopia 19.59 9.76 34 355436 2834 110230995
Blood calcium decreased 19.55 9.76 55 355415 35790 110198039
Drop attacks 19.51 9.76 21 355449 1107 110232722
Suspected suicide attempt 19.47 9.76 13 355457 351 110233478
Colorectal cancer 19.46 9.76 3 355467 9111 110224718
Accidental death 19.45 9.76 47 355423 4962 110228867
Oculogyric crisis 19.43 9.76 40 355430 3792 110230037
Anal incontinence 19.36 9.76 129 355341 21835 110211994
Wheezing 19.34 9.76 649 354821 254581 109979248
Sleep paralysis 19.34 9.76 19 355451 899 110232930
Antidepressant drug level below therapeutic 19.29 9.76 6 355464 22 110233807
Sexual activity increased 19.29 9.76 6 355464 22 110233807
Polymenorrhoea 19.27 9.76 21 355449 1123 110232706
Victim of crime 19.25 9.76 23 355447 1360 110232469
Dementia Alzheimer's type 19.15 9.76 19 355451 910 110232919
Drug-device interaction 19.11 9.76 9 355461 120 110233709
Excessive masturbation 19.11 9.76 9 355461 120 110233709
Postural tremor 19.09 9.76 20 355450 1022 110232807
Morose 19.05 9.76 7 355463 47 110233782
Accidental poisoning 19.01 9.76 31 355439 2456 110231373
Delusional disorder, persecutory type 19.01 9.76 16 355454 618 110233211
Diffuse large B-cell lymphoma 18.98 9.76 14 355456 15884 110217945
Intracranial meningioma malignant 18.97 9.76 4 355466 0 110233829
Cataplexy 18.89 9.76 21 355449 1148 110232681
Nervous system disorder 18.87 9.76 170 355300 31551 110202278
Rash erythematous 18.84 9.76 170 355300 81662 110152167
Granuloma skin 18.77 9.76 79 355391 11204 110222625
Hereditary haemorrhagic telangiectasia 18.76 9.76 8 355462 83 110233746
Schizophreniform disorder 18.72 9.76 10 355460 177 110233652
Water intoxication 18.64 9.76 19 355451 940 110232889
Drug dispensed to wrong patient 18.64 9.76 17 355453 732 110233097
Respiratory tract congestion 18.62 9.76 45 355425 30812 110203017
Malaise 18.61 9.76 1883 353587 669936 109563893
Partner stress 18.58 9.76 12 355458 306 110233523
Blood pressure systolic increased 18.42 9.76 174 355296 82817 110151012
Hyponatraemic encephalopathy 18.42 9.76 13 355457 385 110233444
Distributive shock 18.40 9.76 51 355419 5853 110227976
Oesophageal carcinoma 18.38 9.76 7 355463 11517 110222312
Tuberculosis 18.34 9.76 18 355452 17756 110216073
Boredom 18.32 9.76 6 355464 27 110233802
Product odour abnormal 18.32 9.76 24 355446 1559 110232270
Suspiciousness 18.29 9.76 17 355453 750 110233079
Chronic graft versus host disease 18.29 9.76 4 355466 9453 110224376
Conjunctival abrasion 18.26 9.76 5 355465 10 110233819
Injection site erythema 18.22 9.76 204 355266 93972 110139857
Traumatic haemothorax 18.20 9.76 17 355453 755 110233074
Tubulointerstitial nephritis and uveitis syndrome 18.19 9.76 13 355457 393 110233436
Gastrointestinal motility disorder 18.07 9.76 58 355412 7218 110226611
Multiple-drug resistance 18.06 9.76 10 355460 13225 110220604
Frontotemporal dementia 17.98 9.76 16 355454 667 110233162
Female orgasmic disorder 17.97 9.76 6 355464 29 110233800
Oedema peripheral 17.95 9.76 868 354602 327792 109906037
Maternal drugs affecting foetus 17.92 9.76 24 355446 1593 110232236
Contusion 17.77 9.76 593 354877 232768 110001061
Colitis 17.74 9.76 227 355243 102096 110131733
Burning sensation 17.74 9.76 317 355153 68895 110164934
Stereotypy 17.71 9.76 19 355451 998 110232831
End stage renal disease 17.64 9.76 26 355444 21447 110212382
Enterocolitis 17.55 9.76 21 355449 18928 110214901
Exposure via breast milk 17.54 9.76 19 355451 1009 110232820
Sinus bradycardia 17.54 9.76 158 355312 29325 110204504
Marital problem 17.50 9.76 10 355460 203 110233626
Bronchopulmonary aspergillosis allergic 17.48 9.76 3 355467 8423 110225406
Pelvic pain 17.44 9.76 99 355371 15843 110217986
Skin toxicity 17.44 9.76 8 355462 11775 110222054
Herpes simplex 17.41 9.76 15 355455 15749 110218080
Atrial fibrillation 17.38 9.76 584 354886 229058 110004771
Tenosynovitis 17.38 9.76 16 355454 16267 110217562
Urine chloride decreased 17.38 9.76 8 355462 101 110233728
Blood triglycerides increased 17.32 9.76 134 355336 23792 110210037
Bladder cancer 17.23 9.76 24 355446 20268 110213561
Somatic delusion 17.23 9.76 16 355454 705 110233124
Menopause 17.23 9.76 30 355440 2508 110231321
Reduced facial expression 17.22 9.76 37 355433 3614 110230215
Abnormal loss of weight 17.21 9.76 72 355398 10185 110223644
Pneumonitis 17.18 9.76 160 355310 76371 110157458
Eosinophilic granulomatosis with polyangiitis 17.15 9.76 74 355396 10612 110223217
Dyspareunia 17.14 9.76 28 355442 2221 110231608
Cardiac failure acute 17.14 9.76 32 355438 24046 110209783
Gastritis 17.13 9.76 255 355215 53444 110180385
Hyperuricaemia 17.08 9.76 13 355457 14518 110219311
Feeling guilty 17.05 9.76 18 355452 928 110232901
Inadequate analgesia 16.97 9.76 45 355425 5032 110228797
Shunt malfunction 16.93 9.76 12 355458 358 110233471
Dependence 16.91 9.76 31 355439 2698 110231131
Breath odour 16.84 9.76 26 355444 1966 110231863
Lymphadenopathy 16.79 9.76 128 355342 63707 110170122
Disability 16.76 9.76 46 355424 30177 110203652
Second primary malignancy 16.76 9.76 20 355450 18048 110215781
Hyperactive pharyngeal reflex 16.75 9.76 4 355466 3 110233826
Drug ineffective for unapproved indication 16.70 9.76 441 355029 102397 110131432
CYP3A4 polymorphism 16.64 9.76 7 355463 70 110233759
Abdominal pain upper 16.61 9.76 935 354535 348176 109885653
Pulmonary haemorrhage 16.60 9.76 17 355453 16439 110217390
Accommodation disorder 16.60 9.76 15 355455 638 110233191
Electrocardiogram abnormal 16.57 9.76 110 355360 18599 110215230
Sleep inertia 16.50 9.76 6 355464 39 110233790
Multiple sclerosis 16.47 9.76 140 355330 25558 110208271
Product administration interrupted 16.46 9.76 76 355394 11216 110222613
Neutropenic colitis 16.46 9.76 3 355467 8062 110225767
Postpartum haemorrhage 16.45 9.76 25 355445 1864 110231965
Oral discomfort 16.40 9.76 76 355394 11235 110222594
Injection site pruritus 16.38 9.76 97 355373 51161 110182668
Serum serotonin decreased 16.36 9.76 5 355465 17 110233812
Cholangitis 16.34 9.76 17 355453 16318 110217511
Gun shot wound 16.32 9.76 19 355451 1093 110232736
Spondylitis 16.31 9.76 8 355462 11330 110222499
Threatened labour 16.31 9.76 15 355455 653 110233176
Eczema 16.29 9.76 151 355319 72142 110161687
Localised infection 16.24 9.76 77 355393 42971 110190858
Premature baby 16.19 9.76 43 355427 4812 110229017
Menopausal disorder 16.12 9.76 6 355464 42 110233787
Heart rate decreased 16.11 9.76 179 355291 82577 110151252
Ejection fraction decreased 16.09 9.76 72 355398 40808 110193021
Pulmonary toxicity 16.08 9.76 20 355450 17726 110216103
Alanine aminotransferase abnormal 16.04 9.76 5 355465 9329 110224500
Polyhydramnios 16.02 9.76 25 355445 1908 110231921
Subchorionic haemorrhage 16.00 9.76 9 355461 177 110233652
Akinesia 15.98 9.76 36 355434 3631 110230198
Rhinovirus infection 15.96 9.76 9 355461 11780 110222049
Fear of weight gain 15.94 9.76 5 355465 19 110233810
Aplasia 15.91 9.76 3 355467 7870 110225959
Cough 15.81 9.76 1273 354197 460368 109773461
Fungal infection 15.78 9.76 97 355373 50709 110183120
Subdural haematoma 15.77 9.76 183 355287 36271 110197558
Muscle hypoxia 15.75 9.76 4 355466 5 110233824
Maternal condition affecting foetus 15.74 9.76 9 355461 183 110233646
Genital anaesthesia 15.73 9.76 5 355465 20 110233809
Pneumatosis intestinalis 15.72 9.76 4 355466 8525 110225304
Diverticulitis 15.70 9.76 104 355366 53418 110180411
Erythema 15.66 9.76 771 354699 290676 109943153
Metastases to central nervous system 15.65 9.76 31 355439 22786 110211043
Gallbladder injury 15.64 9.76 20 355450 1268 110232561
Lung opacity 15.62 9.76 9 355461 11643 110222186
Ophthalmic vein thrombosis 15.62 9.76 10 355460 251 110233578
Compulsions 15.57 9.76 12 355458 408 110233421
Vascular dementia 15.55 9.76 17 355453 912 110232917
Drug metabolising enzyme decreased 15.54 9.76 5 355465 21 110233808
Lipidosis 15.54 9.76 6 355464 47 110233782
Muscle spasticity 15.54 9.76 61 355409 35854 110197975
Bladder dilatation 15.48 9.76 28 355442 2411 110231418
Neurosis 15.48 9.76 14 355456 596 110233233
Post concussion syndrome 15.47 9.76 15 355455 698 110233131
Carpal tunnel syndrome 15.47 9.76 125 355345 22485 110211344
Neutropenic sepsis 15.46 9.76 49 355421 30697 110203132
Orthostatic hypotension 15.44 9.76 299 355171 65950 110167879
Uterine contractions during pregnancy 15.40 9.76 13 355457 504 110233325
Premature rupture of membranes 15.39 9.76 41 355429 4596 110229233
Myalgia 15.39 9.76 868 354602 221513 110012316
Trichotillomania 15.35 9.76 9 355461 192 110233637
Overlap syndrome 15.31 9.76 5 355465 9054 110224775
Abnormal uterine bleeding 15.31 9.76 21 355449 1426 110232403
Cellulitis 15.30 9.76 299 355171 125717 110108112
Pseudomonal sepsis 15.28 9.76 5 355465 9041 110224788
Anorectal discomfort 15.26 9.76 38 355432 4088 110229741
Paraneoplastic rash 15.23 9.76 7 355463 88 110233741
Embolic cerebellar infarction 15.18 9.76 5 355465 23 110233806
Drooling 15.16 9.76 54 355416 7085 110226744
Patient elopement 15.15 9.76 11 355459 341 110233488
Daydreaming 15.13 9.76 19 355451 1183 110232646
Selective mutism 15.09 9.76 7 355463 90 110233739
Schizoaffective disorder 15.05 9.76 32 355438 3104 110230725
Kidney transplant rejection 15.04 9.76 10 355460 11977 110221852
Pyromania 15.01 9.76 5 355465 24 110233805
Adverse reaction 14.99 9.76 47 355423 29547 110204282
Exposure via ingestion 14.95 9.76 42 355428 4858 110228971
Substance use 14.94 9.76 28 355442 2478 110231351
Blood ethanol increased 14.89 9.76 14 355456 627 110233202
Plasma cell myeloma 14.82 9.76 130 355340 62806 110171023
Nocardiosis 14.82 9.76 3 355467 7483 110226346
Hepatitis B reactivation 14.81 9.76 3 355467 7481 110226348
Klebsiella infection 14.77 9.76 26 355444 19983 110213846
Gastrointestinal perforation 14.73 9.76 3 355467 7453 110226376
Dysaesthesia 14.72 9.76 52 355418 6795 110227034
Haemolytic anaemia 14.72 9.76 28 355442 20892 110212937
Temporomandibular joint syndrome 14.70 9.76 36 355434 3833 110229996
Complications of transplanted kidney 14.69 9.76 3 355467 7439 110226390
Medication error 14.65 9.76 443 355027 104923 110128906
Amaurosis fugax 14.62 9.76 27 355443 2363 110231466
Product taste abnormal 14.58 9.76 28 355442 2524 110231305
Compulsive sexual behaviour 14.57 9.76 10 355460 283 110233546
Deprescribing error 14.54 9.76 6 355464 57 110233772
Autism spectrum disorder 14.51 9.76 24 355446 1924 110231905
Purple glove syndrome 14.45 9.76 10 355460 287 110233542
Appetite disorder 14.43 9.76 66 355404 9703 110224126
Ocular discomfort 14.40 9.76 60 355410 8473 110225356
Joint hyperextension 14.37 9.76 11 355459 370 110233459
Helplessness 14.35 9.76 11 355459 371 110233458
Abortion missed 14.33 9.76 21 355449 1516 110232313
Premature labour 14.32 9.76 63 355407 9109 110224720
Obsessive rumination 14.29 9.76 4 355466 9 110233820
Newborn persistent pulmonary hypertension 14.29 9.76 4 355466 9 110233820
Postictal headache 14.23 9.76 3 355467 0 110233829
Anaplastic large cell lymphoma T- and null-cell types stage IV 14.23 9.76 3 355467 0 110233829
Arterial ligation 14.23 9.76 3 355467 0 110233829
Overconfidence 14.23 9.76 3 355467 0 110233829
Pulmonary artery wall hypertrophy 14.23 9.76 3 355467 0 110233829
Breast enlargement 14.21 9.76 22 355448 1667 110232162
Lid lag 14.19 9.76 8 355462 158 110233671
Clumsiness 14.18 9.76 35 355435 3745 110230084
Hepatocellular carcinoma 14.17 9.76 7 355463 9873 110223956
Amniotic cavity infection 14.16 9.76 16 355454 891 110232938
Snoring 14.14 9.76 51 355419 6733 110227096
Neutrophil count increased 14.13 9.76 172 355298 34480 110199349
Dermatitis acneiform 14.12 9.76 12 355458 12683 110221146
Tongue biting 14.11 9.76 30 355440 2909 110230920
Immune effector cell-associated neurotoxicity syndrome 14.10 9.76 16 355454 14766 110219063
Endoscopic retrograde cholangiopancreatography 14.09 9.76 9 355461 225 110233604
Myocardial fibrosis 14.09 9.76 24 355446 1971 110231858
Hypomagnesaemia 14.08 9.76 125 355345 60245 110173584
Gastrointestinal sounds abnormal 14.07 9.76 47 355423 5971 110227858
Hunger 14.07 9.76 50 355420 6554 110227275
Orthostatic hypertension 14.06 9.76 17 355453 1018 110232811
Haemorrhagic hepatic cyst 14.01 9.76 6 355464 63 110233766
Hypogammaglobulinaemia 14.01 9.76 27 355443 20049 110213780
Haemangioma of liver 14.01 9.76 20 355450 1410 110232419
Bronchitis 13.93 9.76 391 355079 156641 110077188
Immunisation reaction 13.89 9.76 15 355455 794 110233035
Pulmonary tuberculosis 13.85 9.76 6 355464 9133 110224696
Deafness 13.83 9.76 139 355331 26570 110207259
Rash vesicular 13.82 9.76 16 355454 14636 110219193
Cytomegalovirus chorioretinitis 13.81 9.76 3 355467 7125 110226704
Large intestine perforation 13.79 9.76 20 355450 16609 110217220
Drug tolerance increased 13.79 9.76 13 355457 584 110233245
Mitochondrial encephalomyopathy 13.79 9.76 7 355463 111 110233718
Coital bleeding 13.68 9.76 11 355459 398 110233431
Basophil count abnormal 13.68 9.76 5 355465 33 110233796
Bacteraemia 13.66 9.76 80 355390 42310 110191519
Faeces discoloured 13.62 9.76 168 355302 33780 110200049
Bezoar 13.62 9.76 36 355434 4018 110229811
Atrial septal defect 13.60 9.76 25 355445 2180 110231649
Metastases to lymph nodes 13.56 9.76 17 355453 15015 110218814
Breast discharge 13.55 9.76 16 355454 934 110232895
Oesophageal ulcer haemorrhage 13.53 9.76 16 355454 936 110232893
Skin burning sensation 13.52 9.76 118 355352 21707 110212122
Cardiac flutter 13.49 9.76 45 355425 5712 110228117
Accidental overdose 13.49 9.76 238 355232 51596 110182233
Fatigue 13.49 9.76 3590 351880 1212368 109021461
Mucosal dryness 13.46 9.76 37 355433 4226 110229603
Unmasking of previously unidentified disease 13.46 9.76 29 355441 2839 110230990
Change of bowel habit 13.45 9.76 29 355441 2840 110230989
Hypercapnic coma 13.43 9.76 12 355458 503 110233326
Poor personal hygiene 13.39 9.76 13 355457 606 110233223
Injection site bruising 13.39 9.76 103 355367 51160 110182669
Thermal burn 13.35 9.76 56 355414 7932 110225897
Eosinophilic myocarditis 13.32 9.76 24 355446 2061 110231768
Factor XIII Inhibition 13.31 9.76 5 355465 36 110233793
Levator syndrome 13.31 9.76 5 355465 36 110233793
Patient isolation 13.30 9.76 6 355464 72 110233757
Lactate pyruvate ratio increased 13.30 9.76 6 355464 72 110233757
Alveolar bone resorption 13.30 9.76 6 355464 72 110233757
Staring 13.29 9.76 29 355441 2863 110230966
Impaired self-care 13.28 9.76 27 355443 2537 110231292
Adverse drug reaction 13.26 9.76 249 355221 105310 110128519
Bundle branch block right 13.23 9.76 76 355394 12215 110221614
Retching 13.21 9.76 121 355349 22561 110211268
Renal injury 13.20 9.76 25 355445 18688 110215141
Bankruptcy 13.20 9.76 5 355465 37 110233792
Sleep terror 13.19 9.76 49 355421 6561 110227268
Periarthritis 13.19 9.76 35 355435 3915 110229914
Appendicitis 13.19 9.76 47 355423 28417 110205412
Disturbance in social behaviour 13.18 9.76 41 355429 5017 110228812
Oedematous pancreatitis 13.17 9.76 21 355449 1633 110232196
Tongue haematoma 13.13 9.76 9 355461 254 110233575
Death of relative 13.05 9.76 10 355460 337 110233492
Renal tubular necrosis 13.03 9.76 52 355418 30423 110203406
Death 12.98 9.76 2010 353460 696859 109536970
Ventricular compliance decreased 12.97 9.76 5 355465 39 110233790
Erythromelalgia 12.91 9.76 11 355459 432 110233397
Lack of spontaneous speech 12.89 9.76 9 355461 262 110233567
Angioedema 12.86 9.76 411 355059 98089 110135740
Weight 12.86 9.76 5 355465 40 110233789
Blood parathyroid hormone decreased 12.85 9.76 79 355391 13010 110220819
Slow response to stimuli 12.85 9.76 23 355447 1965 110231864
Dementia 12.82 9.76 157 355313 31516 110202313
Dialysis hypotension 12.81 9.76 8 355462 192 110233637
Implant site irritation 12.80 9.76 7 355463 130 110233699
Inhibitory drug interaction 12.80 9.76 40 355430 4907 110228922
Coagulopathy 12.77 9.76 78 355392 40833 110192996
Respiratory failure 12.69 9.76 564 354906 214768 110019061
Pharyngeal swelling 12.69 9.76 74 355396 11958 110221871
Vasodilation procedure 12.65 9.76 5 355465 42 110233787
Breast cancer stage I 12.62 9.76 4 355466 7383 110226446
Vanishing bile duct syndrome 12.60 9.76 30 355440 3138 110230691
Adulterated product 12.58 9.76 17 355453 1138 110232691
COVID-19 pneumonia 12.56 9.76 69 355401 37074 110196755
Soliloquy 12.56 9.76 16 355454 1011 110232818
Transfusion 12.52 9.76 41 355429 25431 110208398
Autonomic nervous system imbalance 12.52 9.76 44 355426 5736 110228093
Liver function test abnormal 12.47 9.76 300 355170 68650 110165179
Tongue discolouration 12.47 9.76 35 355435 4046 110229783
Female sexual dysfunction 12.35 9.76 5 355465 45 110233784
Device kink 12.35 9.76 23 355447 2026 110231803
Normochromic normocytic anaemia 12.31 9.76 78 355392 12979 110220850
Libido increased 12.29 9.76 26 355444 2513 110231316
Hepatic steatosis 12.28 9.76 223 355247 48608 110185221
Skin neoplasm excision 12.28 9.76 23 355447 2035 110231794
Oropharyngeal blistering 12.28 9.76 15 355455 908 110232921
Laboratory test abnormal 12.26 9.76 87 355383 43992 110189837
Mixed dementia 12.26 9.76 9 355461 284 110233545
Malpositioned teeth 12.25 9.76 5 355465 46 110233783
Target skin lesion 12.23 9.76 9 355461 285 110233544
Device breakage 12.22 9.76 81 355389 13688 110220141
Implant site extravasation 12.21 9.76 15 355455 913 110232916
Hepatic lesion 12.21 9.76 6 355464 8487 110225342
Affect lability 12.19 9.76 102 355368 18535 110215294
Lactation disorder 12.18 9.76 9 355461 287 110233542
Injection site reaction 12.17 9.76 207 355263 88863 110144966
Lymphoproliferative disorder 12.17 9.76 4 355466 7214 110226615
Barbiturates positive 12.16 9.76 3 355467 3 110233826
Nasal cavity packing 12.16 9.76 3 355467 3 110233826
Arterial occlusive disease 12.13 9.76 19 355451 15289 110218540
Skin warm 12.12 9.76 60 355410 9110 110224719
Blood lactate dehydrogenase increased 12.09 9.76 88 355382 44246 110189583
Hepatitis B 12.09 9.76 8 355462 9604 110224225
Platelet aggregation decreased 12.07 9.76 5 355465 48 110233781
Orgasmic sensation decreased 12.07 9.76 5 355465 48 110233781
Cardiac failure chronic 12.07 9.76 16 355454 13795 110220034
Decreased appetite 12.05 9.76 1342 354128 474504 109759325
Ventricular dysfunction 12.04 9.76 52 355418 7459 110226370
Glucose tolerance impaired in pregnancy 12.04 9.76 4 355466 19 110233810
Rubber sensitivity 11.98 9.76 25 355445 2393 110231436
Viral diarrhoea 11.97 9.76 12 355458 582 110233247
Pneumonia aspiration 11.96 9.76 344 355126 80889 110152940
Wrong product administered 11.95 9.76 68 355402 10892 110222937
Abdominal distension 11.95 9.76 451 355019 174652 110059177
Atrioventricular dissociation 11.93 9.76 10 355460 384 110233445
Cushingoid 11.93 9.76 12 355458 11700 110222129
Polymenorrhagia 11.89 9.76 5 355465 50 110233779
Conjunctivitis 11.86 9.76 62 355408 33730 110200099
Poverty of speech 11.85 9.76 12 355458 589 110233240
Gastrointestinal toxicity 11.84 9.76 11 355459 11137 110222692
Eosinophilic cellulitis 11.83 9.76 9 355461 300 110233529
Hypnagogic hallucination 11.82 9.76 8 355462 221 110233608
Dyspraxia 11.80 9.76 9 355461 301 110233528
Sinus congestion 11.78 9.76 54 355416 30405 110203424
Type I hypersensitivity 11.78 9.76 3 355467 6390 110227439
Injection site pain 11.76 9.76 460 355010 177462 110056367
Haemorrhagic disorder 11.75 9.76 21 355449 1792 110232037
Body temperature decreased 11.75 9.76 70 355400 36865 110196964
Dysentery 11.74 9.76 18 355452 1353 110232476
Hepatic failure 11.73 9.76 153 355317 68586 110165243
Nuchal rigidity 11.73 9.76 17 355453 1215 110232614
Morvan syndrome 11.71 9.76 4 355466 21 110233808
Brain death 11.71 9.76 47 355423 6526 110227303
Shoplifting 11.70 9.76 3 355467 4 110233825
Blood citric acid increased 11.63 9.76 5 355465 53 110233776
Delusional perception 11.61 9.76 10 355460 399 110233430
Hypophosphataemia 11.58 9.76 61 355409 33121 110200708
Mallory-Weiss syndrome 11.58 9.76 29 355441 3132 110230697
Parkinsonism hyperpyrexia syndrome 11.57 9.76 12 355458 606 110233223
Salpingo-oophorectomy bilateral 11.53 9.76 9 355461 312 110233517
Cardiotoxicity 11.52 9.76 23 355447 16858 110216971
Hyperaesthesia 11.52 9.76 84 355386 14643 110219186
Parkinson's disease 11.52 9.76 19 355451 1520 110232309
Enteritis 11.51 9.76 28 355442 19128 110214701
Rectal haemorrhage 11.51 9.76 295 355175 119538 110114291
Neoplasm malignant 11.49 9.76 71 355399 37072 110196757
Lymphomatoid papulosis 11.48 9.76 10 355460 405 110233424
Coprolalia 11.47 9.76 5 355465 55 110233774
Endophthalmitis 11.45 9.76 6 355464 8181 110225648
Illusion 11.44 9.76 22 355448 1985 110231844
Mental fatigue 11.44 9.76 15 355455 975 110232854
Rebound psychosis 11.42 9.76 10 355460 408 110233421
Ventricular tachycardia 11.41 9.76 225 355245 49784 110184045
Extrasystoles 11.41 9.76 55 355415 8263 110225566
Anxiety disorder due to a general medical condition 11.41 9.76 4 355466 23 110233806
Sexually transmitted disease 11.40 9.76 7 355463 163 110233666
Painful erection 11.39 9.76 8 355462 235 110233594
Gangrene 11.38 9.76 22 355448 16319 110217510
Sleep talking 11.36 9.76 17 355453 1251 110232578
Abdominal wall disorder 11.35 9.76 10 355460 411 110233418
Antipsychotic drug level decreased 11.34 9.76 18 355452 1394 110232435
Hyporesponsive to stimuli 11.28 9.76 27 355443 2833 110230996
Bladder discomfort 11.27 9.76 14 355456 862 110232967
Coronary artery insufficiency 11.25 9.76 7 355463 167 110233662
Hostility 11.23 9.76 26 355444 2670 110231159
Amyloid related imaging abnormality-oedema/effusion 11.19 9.76 19 355451 1556 110232273
Retroperitoneal fibrosis 11.18 9.76 13 355457 747 110233082
Optic ischaemic neuropathy 11.17 9.76 34 355436 4113 110229716
Nasal oedema 11.17 9.76 4 355466 6835 110226994
Gallbladder disorder 11.16 9.76 110 355360 20919 110212910
Haematocrit abnormal 11.14 9.76 20 355450 1713 110232116
Laryngeal hypertrophy 11.13 9.76 4 355466 25 110233804
Panniculitis 11.13 9.76 87 355383 15495 110218334
Implant site pain 11.09 9.76 23 355447 2192 110231637
Narcolepsy 11.08 9.76 19 355451 1569 110232260
Renal tubular disorder 11.06 9.76 5 355465 7424 110226405
Breast discomfort 11.05 9.76 11 355459 529 110233300
Hypochloraemia 11.02 9.76 31 355439 3587 110230242
Hypervigilance 10.96 9.76 12 355458 645 110233184
Gestational hypertension 10.96 9.76 23 355447 2211 110231618
Foreign body in urogenital tract 10.95 9.76 3 355467 6 110233823
Hippocampal atrophy 10.95 9.76 3 355467 6 110233823
Guillain-Barre syndrome 10.95 9.76 11 355459 10733 110223096
Dependent personality disorder 10.95 9.76 6 355464 112 110233717
Blunted affect 10.95 9.76 11 355459 535 110233294
Arrested labour 10.92 9.76 7 355463 176 110233653
Fluid intake reduced 10.92 9.76 48 355422 6938 110226891
Dropped head syndrome 10.91 9.76 11 355459 537 110233292
Immune-mediated enterocolitis 10.88 9.76 10 355460 10175 110223654
Essential hypertension 10.85 9.76 52 355418 7795 110226034
Alcohol intolerance 10.84 9.76 10 355460 437 110233392
Cardiomegaly 10.77 9.76 142 355328 28988 110204841
Hypotonia 10.75 9.76 87 355383 15658 110218171
Heat exhaustion 10.74 9.76 10 355460 442 110233387
Juvenile idiopathic arthritis 10.72 9.76 3 355467 6004 110227825
Uterine haemorrhage 10.71 9.76 30 355440 3464 110230365
Mitochondrial myopathy 10.71 9.76 10 355460 444 110233385
Seizure like phenomena 10.68 9.76 24 355446 2417 110231412
Cyclothymic disorder 10.66 9.76 8 355462 261 110233568
Product storage error 10.66 9.76 35 355435 21693 110212136
Antidepressant drug level decreased 10.64 9.76 3 355467 7 110233822
Weight fluctuation 10.64 9.76 36 355434 22109 110211720
Gait deviation 10.62 9.76 6 355464 119 110233710
Escherichia infection 10.59 9.76 40 355430 23776 110210053
Trance 10.58 9.76 6 355464 120 110233709
Pulmonary microemboli 10.51 9.76 4 355466 30 110233799
Candida infection 10.51 9.76 101 355369 47908 110185921
Belligerence 10.51 9.76 8 355462 267 110233562
Renal cancer 10.50 9.76 16 355454 13018 110220811
Pregnancy with contraceptive device 10.49 9.76 32 355438 3875 110229954
Hypersensitivity pneumonitis 10.48 9.76 39 355431 5226 110228603
Neurotoxicity 10.47 9.76 86 355384 42121 110191708
Flight of ideas 10.43 9.76 13 355457 803 110233026
Systemic candida 10.41 9.76 10 355460 9964 110223865
Haematochezia 10.41 9.76 287 355183 115237 110118592
Chemical submission 10.39 9.76 11 355459 569 110233260
Initial insomnia 10.39 9.76 63 355407 10326 110223503
Asthma 10.37 9.76 679 354791 249612 109984217
Genital paraesthesia 10.34 9.76 5 355465 71 110233758
Juvenile myoclonic epilepsy 10.34 9.76 5 355465 71 110233758
Drug diversion 10.28 9.76 17 355453 1363 110232466
Idiosyncratic drug reaction 10.22 9.76 18 355452 1518 110232311
Mood disorder due to a general medical condition 10.19 9.76 6 355464 129 110233700
Serum serotonin increased 10.16 9.76 9 355461 373 110233456
Radial nerve palsy 10.13 9.76 10 355460 476 110233353
Pancreatic enzymes decreased 10.10 9.76 3 355467 9 110233820
Electroencephalogram abnormal 10.10 9.76 43 355427 6130 110227699
Serum ferritin increased 10.07 9.76 14 355456 11833 110221996
Eosinophilic pneumonia 10.07 9.76 48 355422 7179 110226650
Heart rate 10.06 9.76 8 355462 285 110233544
Oesophageal disorder 10.05 9.76 27 355443 3043 110230786
Ankylosing spondylitis 10.04 9.76 22 355448 15590 110218239
Acanthosis nigricans 10.02 9.76 7 355463 204 110233625
Pallor 10.01 9.76 245 355225 56222 110177607
Intentional underdose 9.97 9.76 24 355446 2528 110231301
Procedural anxiety 9.88 9.76 13 355457 848 110232981
Macular degeneration 9.88 9.76 36 355434 21623 110212206
Respiratory dyskinesia 9.86 9.76 5 355465 79 110233750
Pelvic inflammatory disease 9.86 9.76 18 355452 1562 110232267
Eyelid myoclonus 9.84 9.76 6 355464 138 110233691
Methaemoglobinaemia 9.80 9.76 9 355461 9159 110224670
Hippocampal sclerosis 9.78 9.76 7 355463 212 110233617
Sweat discolouration 9.78 9.76 4 355466 37 110233792

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Agitation neonatal 30.34 19.22 60 2615 711 110567
Premature baby 27.01 19.22 48 2627 4926 106352
Low birth weight baby 23.79 19.22 6 2669 1745 109533
Off label use 23.00 19.22 3 2672 1404 109874
Human herpesvirus 6 infection 21.93 19.22 15 2660 45 111233
Pulmonary artery stenosis 19.62 19.22 21 2654 133 111145
Tardive dyskinesia 19.54 19.22 12 2663 28 111250
Grunting 19.44 19.22 7 2668 0 111278

Pharmacologic Action:

SourceCodeDescription
ATC N06AB06 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
FDA EPC N0000175696 Serotonin Reuptake Inhibitor
FDA MoA N0000182137 Cytochrome P450 2D6 Inhibitors
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:50949 serotonin uptake inhibitor
MeSH PA D000928 Antidepressive Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D017367 Selective Serotonin Reuptake Inhibitors
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018490 Serotonin Agents
MeSH PA D049990 Membrane Transport Modulators

Related Drugs by ATC class:

N06AB Selective serotonin reuptake inhibitors 7 drugs
citalopramescitaloprametoperidonefluoxetinefluvoxamineparoxetinezimeldine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Premenstrual dysphoric disorder indication 596004
Social phobia indication 25501002 DOID:11257
Depressive disorder indication 35489007
Posttraumatic stress disorder indication 47505003 DOID:2055
Obsessive-compulsive disorder indication 191736004 DOID:10933
Panic disorder indication 371631005 DOID:594
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Seasonal affective disorder off-label use 247803002
Cholestatic pruritus off-label use 707150004
Suicidal thoughts contraindication 6471006
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Upper gastrointestinal hemorrhage contraindication 37372002
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Blood coagulation disorder contraindication 64779008 DOID:1247
Weight loss contraindication 89362005
Hyponatremia contraindication 89627008
Seizure disorder contraindication 128613002
Mania contraindication 231494001
Hypomania contraindication 231496004
Disease of liver contraindication 235856003 DOID:409
Serotonin syndrome contraindication 371089000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.61 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 150MG BASE SERTRALINE HYDROCHLORIDE ZENARA A218853 July 16, 2025 RX CAPSULE ORAL Jan. 18, 2026 COMPETITIVE GENERIC THERAPY
EQ 200MG BASE SERTRALINE HYDROCHLORIDE ZENARA A218853 July 16, 2025 RX CAPSULE ORAL Jan. 18, 2026 COMPETITIVE GENERIC THERAPY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 9.54 CHEMBL CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 7.24 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel Ki 5.17 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Kd 6.38 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR Ki 6.11 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 5.67 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.25 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR Ki 6.86 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 7.08 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 6.13 PDSP
Muscarinic acetylcholine receptor M2 GPCR Ki 5.68 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 5.89 PDSP
Muscarinic acetylcholine receptor M4 GPCR Ki 5.85 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 5.72 PDSP
Alpha-2C adrenergic receptor GPCR Ki 6.19 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Kd 7.60 WOMBAT-PK
Cytochrome P450 2C19 Enzyme IC50 6 DRUG MATRIX
Melanocortin receptor 5 GPCR Ki 5.37 DRUG MATRIX
Alpha-2A adrenergic receptor GPCR Ki 6.97 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 6.48 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 5.89 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 9.07 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 7.11 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 7.24 CHEMBL
Transporter Transporter Ki 6.80 CHEMBL
Transcriptional activator protein luxR Transcription factor IC50 4.57 CHEMBL
Sigma intracellular receptor 2 Membrane receptor Ki 5.28 CHEMBL

External reference:

IDSource
4020551 VUID
N0000148257 NUI
D00825 KEGG_DRUG
79559-97-0 SECONDARY_CAS_RN
4020394 VANDF
4020551 VANDF
C0074393 UMLSCUI
CHEBI:9123 CHEBI
SRE PDB_CHEM_ID
CHEMBL809 ChEMBL_ID
CHEMBL1709 ChEMBL_ID
DB01104 DRUGBANK_ID
D020280 MESH_DESCRIPTOR_UI
68617 PUBCHEM_CID
4798 IUPHAR_LIGAND_ID
5277 INN_ID
QUC7NX6WMB UNII
155137 RXNORM
169461 MMSL
39959 MMSL
5457 MMSL
83167 MMSL
d00880 MMSL
003629 NDDF
004615 NDDF
321958004 SNOMEDCT_US
372594008 SNOMEDCT_US
96211006 SNOMEDCT_US
QUC7NX6WMB INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9580 TABLET, FILM COATED 100 mg ORAL ANDA 31 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9581 TABLET, FILM COATED 50 mg ORAL ANDA 31 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9582 TABLET, FILM COATED 25 mg ORAL ANDA 31 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8596 TABLET, FILM COATED 25 mg ORAL ANDA 30 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8603 TABLET, FILM COATED 50 mg ORAL ANDA 30 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8604 TABLET, FILM COATED 100 mg ORAL ANDA 30 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6924 TABLET, FILM COATED 25 mg ORAL ANDA 30 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6925 TABLET, FILM COATED 50 mg ORAL ANDA 30 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6926 TABLET, FILM COATED 100 mg ORAL ANDA 30 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10135-694 SOLUTION 20 mg ORAL ANDA 28 sections
Sertraline Hydrochloride Human Prescription Drug Label 1 13107-011 TABLET 25 mg ORAL ANDA 26 sections
Sertraline Hydrochloride Human Prescription Drug Label 1 13107-012 TABLET 50 mg ORAL ANDA 26 sections
Sertraline Hydrochloride Human Prescription Drug Label 1 13107-013 TABLET 100 mg ORAL ANDA 26 sections
ZOLOFT HUMAN PRESCRIPTION DRUG LABEL 1 16590-250 TABLET, FILM COATED 50 mg ORAL NDA 31 sections
ZOLOFT HUMAN PRESCRIPTION DRUG LABEL 1 16590-251 TABLET, FILM COATED 100 mg ORAL NDA 31 sections
SERTRALINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-416 TABLET 100 mg ORAL ANDA 25 sections
SERTRALINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-457 TABLET 50 mg ORAL ANDA 25 sections
SERTRALINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-700 TABLET 25 mg ORAL ANDA 25 sections
Sertraline Hydrochloride Human Prescription Drug Label 1 16714-601 SOLUTION 20 mg ORAL ANDA 30 sections
Sertraline Hydrochloride Human Prescription Drug Label 1 16714-611 TABLET, FILM COATED 25 mg ORAL ANDA 31 sections
Sertraline Hydrochloride Human Prescription Drug Label 1 16714-612 TABLET, FILM COATED 50 mg ORAL ANDA 31 sections
Sertraline Hydrochloride Human Prescription Drug Label 1 16714-613 TABLET, FILM COATED 100 mg ORAL ANDA 31 sections
SERTRALINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16729-215 TABLET, FILM COATED 25 mg ORAL ANDA 30 sections
SERTRALINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16729-216 TABLET, FILM COATED 50 mg ORAL ANDA 30 sections
SERTRALINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16729-217 TABLET, FILM COATED 100 mg ORAL ANDA 30 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-164 TABLET, FILM COATED 25 mg ORAL ANDA 30 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-165 TABLET, FILM COATED 50 mg ORAL ANDA 30 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-166 TABLET, FILM COATED 100 mg ORAL ANDA 30 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 23155-757 TABLET, FILM COATED 25 mg ORAL ANDA 29 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 23155-758 TABLET, FILM COATED 50 mg ORAL ANDA 29 sections