sertraline ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
serotonin reuptake inhibitors 2436 79617-96-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sertraline
  • sertraline hydrochloride
  • sertraline HCl
A selective serotonin uptake inhibitor that is used in the treatment of depression.
  • Molecular weight: 306.23
  • Formula: C17H17Cl2N
  • CLOGP: 5.35
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 1
  • TPSA: 12.03
  • ALOGS: -6.32
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 3.80 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.20 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 9.33 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 44 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
fu (Fraction unbound in plasma) 0.00 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

DateAgencyCompanyOrphan
Dec. 30, 1991 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intentional self-injury 1376.95 9.64 969 234126 24718 63229209
Intentional overdose 1252.14 9.64 1457 233638 72695 63181232
Serotonin syndrome 946.96 9.64 812 234283 27870 63226057
Suicide attempt 918.11 9.64 1130 233965 59788 63194139
Suicidal ideation 853.49 9.64 1103 233992 61318 63192609
Drug abuse 768.26 9.64 1133 233962 71385 63182542
Pemphigus 662.03 9.64 3 235092 183723 63070204
Hand deformity 528.56 9.64 13 235082 159444 63094483
Systemic lupus erythematosus 506.35 9.64 83 235012 208835 63045092
Drug interaction 485.83 9.64 1904 233191 227227 63026700
Contraindicated product administered 479.90 9.64 109 234986 217539 63036388
Anxiety 476.11 9.64 1826 233269 215715 63038212
Glossodynia 461.46 9.64 59 235036 178817 63075110
Synovitis 453.51 9.64 74 235021 186844 63067083
Agitation 429.71 9.64 784 234311 58973 63194954
Completed suicide 389.48 9.64 1306 233789 144367 63109560
Joint swelling 365.34 9.64 405 234690 327261 62926666
Tremor 357.41 9.64 1190 233905 131049 63122878
Pericarditis 355.28 9.64 37 235058 131542 63122385
Drug intolerance 347.95 9.64 378 234717 308283 62945644
Arthropathy 342.52 9.64 224 234871 234568 63019359
Toxicity to various agents 340.20 9.64 1809 233286 245441 63008486
Alopecia 330.40 9.64 461 234634 337075 62916852
Treatment failure 324.29 9.64 166 234929 198877 63055050
Infusion related reaction 308.58 9.64 273 234822 245248 63008679
Akathisia 308.01 9.64 262 234833 8884 63245043
Withdrawal syndrome 304.33 9.64 373 234722 19624 63234303
Swelling 296.39 9.64 350 234745 275028 62978899
Rheumatoid arthritis 285.77 9.64 311 234784 253508 63000419
Sopor 283.11 9.64 379 234716 21785 63232142
Duodenal ulcer perforation 278.39 9.64 10 235085 87199 63166728
Helicobacter infection 272.72 9.64 18 235077 92767 63161160
Depression 261.49 9.64 1425 233670 195067 63058860
Abnormal behaviour 254.93 9.64 354 234741 21072 63232855
Drug ineffective 248.69 9.64 2576 232519 1042189 62211738
Wound 247.31 9.64 149 234946 163114 63090813
Abdominal discomfort 240.28 9.64 519 234576 320366 62933561
Somnolence 234.44 9.64 1291 233804 177394 63076533
Therapeutic product effect decreased 232.94 9.64 223 234872 192964 63060963
Hallucination 224.91 9.64 573 234522 54244 63199683
Hallucination, auditory 224.56 9.64 257 234838 12567 63241360
Panic attack 219.31 9.64 337 234758 21994 63231933
Folliculitis 217.92 9.64 10 235085 70307 63183620
Overdose 217.81 9.64 924 234171 114154 63139773
Hyponatraemia 216.86 9.64 905 234190 110995 63142932
Rash 207.78 9.64 1223 233872 559648 62694279
Aggression 206.46 9.64 337 234758 23161 63230766
Mania 201.78 9.64 239 234856 12128 63241799
Arthralgia 199.69 9.64 1264 233831 568446 62685481
Paranoia 196.02 9.64 229 234866 11450 63242477
Discomfort 195.08 9.64 199 234896 167175 63086752
Psychotic disorder 190.67 9.64 342 234753 25370 63228557
Hepatic enzyme increased 190.18 9.64 284 234811 202044 63051883
Muscle injury 188.18 9.64 14 235081 65331 63188596
Bruxism 181.89 9.64 130 234965 3395 63250532
Nasopharyngitis 177.44 9.64 427 234668 253830 63000097
Mydriasis 173.86 9.64 218 234877 11738 63242189
Product use issue 172.23 9.64 348 234747 220172 63033755
Restlessness 168.46 9.64 351 234744 29102 63224825
Extrapyramidal disorder 158.80 9.64 220 234875 13064 63240863
Hypersensitivity 157.95 9.64 555 234540 292130 62961797
Blister 153.92 9.64 152 234943 129662 63124265
Off label use 152.82 9.64 1680 233415 672782 62581145
Stomatitis 152.66 9.64 173 234922 138552 63115375
Disorientation 152.16 9.64 403 234692 39049 63214878
Self-injurious ideation 151.03 9.64 104 234991 2555 63251372
Rheumatoid factor positive 148.78 9.64 63 235032 84343 63169584
Drug withdrawal syndrome 147.33 9.64 317 234778 26877 63227050
Pain 146.32 9.64 1901 233194 738727 62515200
Peripheral swelling 145.69 9.64 501 234594 265441 62988486
Impaired healing 143.80 9.64 102 234993 102440 63151487
Disturbance in attention 143.15 9.64 386 234709 37803 63216124
Depressed mood 141.48 9.64 397 234698 39794 63214133
Dyskinesia 139.09 9.64 342 234753 31660 63222267
Tic 135.33 9.64 79 235016 1441 63252486
Electrocardiogram QT prolonged 135.06 9.64 506 234589 59024 63194903
Hallucinations, mixed 134.03 9.64 124 234971 4705 63249222
Seizure 133.58 9.64 895 234200 131739 63122188
Insomnia 133.06 9.64 1299 233796 213953 63039974
C-reactive protein abnormal 132.37 9.64 10 235085 46086 63207841
Infection 130.80 9.64 424 234671 228749 63025178
Lower respiratory tract infection 127.90 9.64 182 234913 132125 63121802
Galactorrhoea 127.72 9.64 113 234982 4042 63249885
Anger 126.57 9.64 191 234904 12265 63241662
Irritability 126.56 9.64 328 234767 31366 63222561
Delusion 124.58 9.64 186 234909 11831 63242096
Pyrexia 123.77 9.64 1130 233965 469348 62784579
Hypomania 121.34 9.64 133 234962 6197 63247730
Crying 118.39 9.64 265 234830 23078 63230849
Feeling abnormal 118.29 9.64 947 234148 147445 63106482
Foetal exposure during pregnancy 117.73 9.64 321 234774 31641 63222286
Confusional state 115.56 9.64 1361 233734 235019 63018908
Psoriatic arthropathy 114.54 9.64 102 234993 91418 63162509
Irritable bowel syndrome 114.20 9.64 83 235012 82329 63171598
Hyperreflexia 112.57 9.64 124 234971 5810 63248117
Loss of consciousness 112.35 9.64 786 234309 117335 63136592
Dizziness 112.05 9.64 2223 232872 427702 62826225
Myoclonus 111.22 9.64 206 234889 15662 63238265
Poisoning deliberate 111.13 9.64 170 234925 11048 63242879
Hyperprolactinaemia 109.90 9.64 101 234994 3799 63250128
Febrile neutropenia 109.54 9.64 168 234927 118281 63135646
Sinusitis 107.87 9.64 452 234643 226201 63027726
General physical health deterioration 107.83 9.64 383 234712 201019 63052908
Psychomotor hyperactivity 106.21 9.64 162 234933 10501 63243426
Hallucination, visual 105.73 9.64 226 234869 19072 63234855
Homicidal ideation 105.39 9.64 71 235024 1681 63252246
Thinking abnormal 105.03 9.64 161 234934 10482 63243445
Apathy 104.15 9.64 145 234950 8649 63245278
Dystonia 102.69 9.64 184 234911 13635 63240292
Emotional distress 101.58 9.64 308 234787 32241 63221686
Mental disorder 101.20 9.64 266 234829 25653 63228274
Mood swings 98.02 9.64 212 234883 18036 63235891
Amenorrhoea 97.87 9.64 150 234945 9764 63244163
Muscle rigidity 97.07 9.64 162 234933 11338 63242589
Inappropriate antidiuretic hormone secretion 96.40 9.64 191 234904 15271 63238656
Ill-defined disorder 95.42 9.64 97 234998 81658 63172269
Hyperhidrosis 94.71 9.64 704 234391 107132 63146795
Intentional product use issue 93.77 9.64 209 234886 127683 63126244
Infarction 93.75 9.64 78 235017 2563 63251364
Treatment noncompliance 92.03 9.64 326 234769 36999 63216928
Nightmare 91.90 9.64 213 234882 18981 63234946
Hip arthroplasty 91.57 9.64 31 235064 47615 63206312
Poisoning 91.22 9.64 174 234921 13526 63240401
Suicidal behaviour 87.63 9.64 75 235020 2564 63251363
Product substitution issue 87.25 9.64 187 234908 15809 63238118
Knee arthroplasty 85.54 9.64 47 235048 54159 63199768
Gastrointestinal disorder 84.80 9.64 229 234866 131010 63122917
Bradyphrenia 84.03 9.64 116 234979 6864 63247063
Neuroleptic malignant syndrome 83.85 9.64 156 234939 11900 63242027
Parkinsonism 82.75 9.64 143 234952 10296 63243631
Homicide 81.67 9.64 36 235059 349 63253578
Trismus 80.39 9.64 85 235010 3800 63250127
Tardive dyskinesia 78.86 9.64 125 234970 8377 63245550
Social avoidant behaviour 75.80 9.64 73 235022 2915 63251012
Salivary hypersecretion 75.69 9.64 116 234979 7550 63246377
Colitis microscopic 75.43 9.64 129 234966 9210 63244717
Malignant neoplasm progression 75.41 9.64 117 234978 82004 63171923
Libido decreased 74.91 9.64 69 235026 2603 63251324
Anorgasmia 74.79 9.64 39 235056 564 63253363
Schizophrenia 74.57 9.64 133 234962 9819 63244108
Emotional disorder 71.36 9.64 155 234940 13224 63240703
Rhabdomyolysis 71.11 9.64 337 234758 43614 63210313
Gestational diabetes 70.50 9.64 118 234977 8278 63245649
Musculoskeletal stiffness 68.88 9.64 401 234694 184217 63069710
Tachycardia 68.53 9.64 704 234391 117452 63136475
Abnormal dreams 68.10 9.64 132 234963 10384 63243543
Major depression 67.74 9.64 113 234982 7905 63246022
Vertigo 67.54 9.64 416 234679 59471 63194456
Generalised tonic-clonic seizure 66.93 9.64 248 234847 28768 63225159
Dysarthria 66.58 9.64 324 234771 42387 63211540
Loss of libido 65.61 9.64 48 235047 1301 63252626
Mental impairment 65.52 9.64 155 234940 13996 63239931
Obsessive-compulsive disorder 65.46 9.64 78 235017 3982 63249945
Oromandibular dystonia 65.12 9.64 34 235061 493 63253434
Drug dependence 63.97 9.64 218 234877 24265 63229662
Respiratory arrest 63.93 9.64 265 234830 32380 63221547
Drug screen false positive 63.40 9.64 40 235055 844 63253083
Yawning 63.13 9.64 43 235052 1037 63252890
Formication 62.00 9.64 78 235017 4213 63249714
Activation syndrome 61.19 9.64 25 235070 197 63253730
Product complaint 61.16 9.64 142 234953 12667 63241260
Mobility decreased 61.13 9.64 236 234859 120923 63133004
Renal impairment 61.05 9.64 149 234946 88206 63165721
Blood prolactin increased 60.98 9.64 70 235025 3433 63250494
Impulsive behaviour 60.91 9.64 49 235046 1534 63252393
Maculopathy 60.69 9.64 57 235038 2205 63251722
Flat affect 60.34 9.64 47 235048 1403 63252524
Psychomotor retardation 60.19 9.64 73 235022 3797 63250130
Reversible cerebral vasoconstriction syndrome 60.12 9.64 61 235034 2597 63251330
Intentional product misuse 60.03 9.64 409 234686 60508 63193419
Disease progression 59.47 9.64 243 234852 122515 63131412
Bradykinesia 59.15 9.64 84 235011 5104 63248823
Neutropenia 58.62 9.64 393 234702 174612 63079315
C-reactive protein increased 57.66 9.64 170 234925 94537 63159390
Cardiac arrest 57.32 9.64 559 234536 91986 63161941
Negative thoughts 56.80 9.64 38 235057 889 63253038
Muscle twitching 56.63 9.64 181 234914 19487 63234440
Agitation neonatal 56.14 9.64 31 235064 506 63253421
Musculoskeletal pain 55.92 9.64 166 234929 92111 63161816
Fall 55.25 9.64 1870 233225 390464 62863463
Coma 55.24 9.64 418 234677 63946 63189981
Mood altered 55.22 9.64 149 234946 14594 63239333
Persistent genital arousal disorder 55.10 9.64 25 235070 261 63253666
Delirium 54.45 9.64 347 234748 50194 63203733
Depressed level of consciousness 54.32 9.64 405 234690 61673 63192254
Fear 53.78 9.64 154 234941 15612 63238315
Newborn persistent pulmonary hypertension 53.19 9.64 23 235072 212 63253715
Alcoholism 53.02 9.64 48 235047 1770 63252157
Fibromyalgia 52.94 9.64 139 234956 80281 63173646
Euphoric mood 52.61 9.64 77 235018 4810 63249117
Stiff person syndrome 51.54 9.64 25 235070 307 63253620
Drug withdrawal syndrome neonatal 51.21 9.64 50 235045 2031 63251896
Speech disorder 50.81 9.64 290 234805 40339 63213588
Affective disorder 49.77 9.64 85 235010 6061 63247866
Liver injury 49.34 9.64 93 235002 60427 63193500
Maternal exposure during pregnancy 49.21 9.64 549 234546 219513 63034414
Psychotic symptom 49.07 9.64 43 235052 1518 63252409
Complication of device insertion 49.05 9.64 95 235000 7469 63246458
Pleurothotonus 48.21 9.64 40 235055 1309 63252618
Therapeutic product effect incomplete 48.04 9.64 269 234826 124787 63129140
Syncope 47.95 9.64 654 234441 116731 63137196
Intrusive thoughts 47.34 9.64 21 235074 207 63253720
Eye movement disorder 47.30 9.64 76 235019 5152 63248775
Sensation of foreign body 47.13 9.64 72 235023 4673 63249254
Cytomegalovirus infection 47.11 9.64 10 235085 20942 63232985
Burning mouth syndrome 46.66 9.64 27 235068 484 63253443
Sedation 46.57 9.64 274 234821 38535 63215392
Cholecystitis chronic 46.37 9.64 112 234983 10249 63243678
Inflammation 46.32 9.64 153 234942 82120 63171807
Drug screen positive 46.24 9.64 62 235033 3567 63250360
Psychomotor skills impaired 45.82 9.64 50 235045 2318 63251609
Memory impairment 45.54 9.64 588 234507 103670 63150257
Thrombocytopenia 45.49 9.64 350 234745 150807 63103120
Bone erosion 45.26 9.64 6 235089 17711 63236216
Torticollis 44.58 9.64 45 235050 1904 63252023
Thermal burn 44.28 9.64 80 235015 5966 63247961
Anhedonia 44.24 9.64 114 234981 10860 63243067
Pregnancy with implant contraceptive 44.01 9.64 52 235043 2631 63251296
Restless legs syndrome 43.25 9.64 159 234936 18372 63235555
Abnormal weight gain 43.23 9.64 43 235052 1787 63252140
Pancytopenia 43.21 9.64 198 234897 96735 63157192
Lung disorder 43.00 9.64 105 234990 62156 63191771
Eosinophilic pneumonia acute 42.91 9.64 24 235071 402 63253525
Swollen tongue 42.60 9.64 247 234848 34553 63219374
Balance disorder 42.46 9.64 489 234606 83933 63169994
Type 2 diabetes mellitus 42.33 9.64 110 234985 63758 63190169
Abulia 42.25 9.64 25 235070 468 63253459
Flashback 42.09 9.64 18 235077 161 63253766
Tension 41.62 9.64 55 235040 3120 63250807
Emotional poverty 41.07 9.64 22 235073 337 63253590
Bipolar disorder 41.07 9.64 91 235004 7869 63246058
Mucosal inflammation 41.06 9.64 69 235026 46859 63207068
Conversion disorder 40.85 9.64 41 235054 1723 63252204
Respiratory disorder neonatal 40.56 9.64 35 235060 1210 63252717
Cardiac failure 40.38 9.64 181 234914 88961 63164966
Heavy menstrual bleeding 40.23 9.64 151 234944 17622 63236305
Upper gastrointestinal haemorrhage 40.07 9.64 157 234938 18695 63235232
Rabbit syndrome 39.83 9.64 21 235074 311 63253616
Mental status changes 39.68 9.64 267 234828 39332 63214595
Drowning 39.66 9.64 24 235071 469 63253458
Palpitations 39.60 9.64 612 234483 112158 63141769
Depersonalisation/derealisation disorder 39.58 9.64 36 235059 1336 63252591
Pain in extremity 39.56 9.64 930 234165 330556 62923371
Pulmonary embolism 39.37 9.64 629 234466 116055 63137872
Fatigue 39.37 9.64 2796 232299 885232 62368695
Device dislocation 39.34 9.64 194 234901 25511 63228416
Schizoaffective disorder bipolar type 39.17 9.64 16 235079 126 63253801
Depressive symptom 39.00 9.64 61 235034 4041 63249886
Cycloplegia 38.84 9.64 9 235086 3 63253924
Conjunctival abrasion 38.62 9.64 11 235084 22 63253905
Arthritis 38.46 9.64 261 234834 115660 63138267
Myelosuppression 38.20 9.64 20 235075 23683 63230244
Victim of chemical submission 37.97 9.64 24 235071 508 63253419
Vision blurred 37.88 9.64 513 234582 91411 63162516
Pruritus 37.79 9.64 1034 234061 360419 62893508
Catatonia 37.69 9.64 63 235032 4414 63249513
Wrong patient 37.55 9.64 18 235077 215 63253712
Cerebral vasoconstriction 37.42 9.64 33 235062 1175 63252752
Clonus 37.39 9.64 64 235031 4572 63249355
Hypersomnia 37.28 9.64 149 234946 17906 63236021
Lethargy 37.00 9.64 343 234752 55664 63198263
Retroplacental haematoma 36.95 9.64 16 235079 148 63253779
Therapy non-responder 36.91 9.64 150 234945 75751 63178176
Bursitis 36.72 9.64 50 235045 36991 63216936
Disorganised speech 36.11 9.64 33 235062 1232 63252695
Neuropathy peripheral 35.71 9.64 260 234835 113407 63140520
Death 35.61 9.64 1085 234010 373296 62880631
Hallucination, olfactory 35.35 9.64 18 235077 247 63253680
Tremor neonatal 35.19 9.64 15 235080 133 63253794
Metabolic syndrome 35.11 9.64 36 235059 1552 63252375
Cardio-respiratory arrest 34.62 9.64 357 234738 59602 63194325
Substance abuse 34.43 9.64 63 235032 4744 63249183
Grip strength decreased 34.19 9.64 20 235075 22267 63231660
Hyponatraemic seizure 34.18 9.64 21 235074 422 63253505
Urinary incontinence 33.98 9.64 219 234876 31795 63222132
Brain injury 33.54 9.64 78 235017 6965 63246962
Psychiatric symptom 33.14 9.64 65 235030 5158 63248769
Nystagmus 33.10 9.64 72 235023 6148 63247779
Uterine perforation 33.03 9.64 77 235018 6886 63247041
Somatic symptom disorder of pregnancy 33.01 9.64 13 235082 92 63253835
Blood cholesterol increased 32.56 9.64 209 234886 93823 63160104
Inappropriate affect 32.46 9.64 27 235068 887 63253040
Eosinophilic myocarditis 32.30 9.64 23 235072 597 63253330
Hypotonia 31.96 9.64 91 235004 9194 63244733
Therapeutic response unexpected 31.93 9.64 146 234949 18613 63235314
Septic shock 31.57 9.64 133 234962 66496 63187431
Unresponsive to stimuli 31.52 9.64 224 234871 33592 63220335
Acute kidney injury 31.41 9.64 739 234356 262676 62991251
Neonatal respiratory distress syndrome 31.21 9.64 45 235050 2773 63251154
Alcohol poisoning 31.16 9.64 37 235058 1882 63252045
Nervousness 31.11 9.64 209 234886 30770 63223157
Sexual dysfunction 31.06 9.64 57 235038 4302 63249625
Depression suicidal 31.01 9.64 36 235059 1787 63252140
Obsessive thoughts 30.96 9.64 22 235073 569 63253358
Injection site pain 30.93 9.64 319 234776 129481 63124446
Embedded device 30.65 9.64 50 235045 3433 63250494
Foaming at mouth 30.51 9.64 29 235066 1139 63252788
Phobia 30.47 9.64 18 235077 336 63253591
Pancreatic fibrosis 30.35 9.64 12 235083 86 63253841
Suppressed lactation 30.34 9.64 20 235075 456 63253471
Neutrophil count decreased 30.32 9.64 107 234988 56299 63197628
Osteoporosis 30.00 9.64 110 234985 57228 63196699
Posture abnormal 29.96 9.64 40 235055 2292 63251635
Joint range of motion decreased 29.95 9.64 46 235049 32382 63221545
Hyponatraemic syndrome 29.86 9.64 21 235074 534 63253393
Neonatal asphyxia 29.61 9.64 17 235078 300 63253627
Bradycardia neonatal 29.48 9.64 26 235069 926 63253001
Confabulation 29.47 9.64 17 235078 303 63253624
Alcohol abuse 29.41 9.64 38 235057 2108 63251819
Logorrhoea 29.15 9.64 41 235054 2469 63251458
Poverty of thought content 29.15 9.64 8 235087 13 63253914
Device placement issue 28.95 9.64 30 235065 1310 63252617
Perinatal depression 28.92 9.64 23 235072 708 63253219
Hyperthermia 28.90 9.64 87 235008 9069 63244858
Dysphemia 28.58 9.64 42 235053 2633 63251294
Autoimmune disorder 28.42 9.64 14 235081 17163 63236764
Maternal drugs affecting foetus 28.26 9.64 61 235034 5181 63248746
Platelet count decreased 28.24 9.64 284 234811 115838 63138089
Bipolar I disorder 28.21 9.64 35 235060 1864 63252063
Violence-related symptom 28.11 9.64 18 235077 390 63253537
Vomiting 28.09 9.64 2421 232674 557196 62696731
Device expulsion 27.85 9.64 223 234872 34699 63219228
Adverse event 27.78 9.64 142 234953 67417 63186510
Adrenal insufficiency 27.59 9.64 16 235079 17899 63236028
Anaemia 27.48 9.64 852 234243 292578 62961349
Central vision loss 27.46 9.64 8 235087 18 63253909
Jaundice cholestatic 27.41 9.64 74 235021 7250 63246677
Hemivertebra 27.16 9.64 12 235083 117 63253810
Antipsychotic drug level increased 27.15 9.64 47 235048 3388 63250539
Caesarean section 27.11 9.64 130 234965 16902 63237025
Amnesia 27.07 9.64 320 234775 55265 63198662
Tinnitus 27.06 9.64 225 234870 35403 63218524
Facet joint syndrome 26.87 9.64 6 235089 12132 63241795
Tearfulness 26.86 9.64 52 235043 4087 63249840
Muscle tightness 26.85 9.64 101 234994 11799 63242128
Borderline personality disorder 26.83 9.64 23 235072 788 63253139
Disturbance in sexual arousal 26.73 9.64 12 235083 122 63253805
Intermenstrual bleeding 26.62 9.64 77 235018 7849 63246078
Sepsis 26.47 9.64 403 234692 152720 63101207
Coordination abnormal 26.33 9.64 111 234984 13662 63240265
Haemophagocytic lymphohistiocytosis 26.21 9.64 4 235091 10623 63243304
Cold sweat 26.15 9.64 101 234994 11946 63241981
Merycism 26.07 9.64 15 235080 266 63253661
Foreign body in reproductive tract 26.03 9.64 22 235073 739 63253188
Somnambulism 25.97 9.64 61 235034 5482 63248445
Incoherent 25.91 9.64 54 235041 4476 63249451
Chorea 25.85 9.64 31 235064 1593 63252334
Altered state of consciousness 25.81 9.64 171 234924 25059 63228868
Idiopathic intracranial hypertension 25.69 9.64 42 235053 2889 63251038
Hypokinesia 25.63 9.64 111 234984 13825 63240102
Bundle branch block right 25.63 9.64 57 235038 4941 63248986
Drug dose titration not performed 25.62 9.64 19 235076 526 63253401
Respiratory tract infection 25.58 9.64 74 235021 41409 63212518
Osteoarthritis 25.39 9.64 228 234867 95115 63158812
Multiple sclerosis relapse 25.36 9.64 283 234812 48195 63205732
Large for dates baby 25.35 9.64 18 235077 465 63253462
Impulse-control disorder 25.31 9.64 22 235073 768 63253159
Product tampering 25.29 9.64 17 235078 401 63253526
Miosis 25.25 9.64 72 235023 7281 63246646
Herpes zoster 25.24 9.64 190 234905 82272 63171655
White blood cell count decreased 25.11 9.64 363 234732 138741 63115186
Tachyphrenia 24.84 9.64 28 235067 1346 63252581
Adjustment disorder with depressed mood 24.81 9.64 4 235091 10200 63243727
Long QT syndrome 24.80 9.64 44 235051 3235 63250692
Adulterated product 24.54 9.64 14 235081 244 63253683
Pneumonia 24.45 9.64 1413 233682 455354 62798573
Urinary retention 24.44 9.64 194 234901 30107 63223820
Asthma-chronic obstructive pulmonary disease overlap syndrome 24.43 9.64 34 235061 2027 63251900
Sciatica 24.40 9.64 57 235038 34267 63219660
Pleural effusion 24.34 9.64 224 234871 92986 63160941
Dyspnoea 24.25 9.64 2114 232981 659199 62594728
Factor XIII deficiency 24.24 9.64 10 235085 81 63253846
Oedema 24.05 9.64 238 234857 97384 63156543
Hereditary angioedema 24.00 9.64 72 235023 7490 63246437
Injection site erythema 23.89 9.64 195 234900 82979 63170948
Leukopenia 23.69 9.64 178 234917 77112 63176815
Blood creatine phosphokinase increased 23.55 9.64 193 234902 30237 63223690
Chronic obstructive pulmonary disease 23.47 9.64 344 234751 62342 63191585
Persistent foetal circulation 23.39 9.64 13 235082 215 63253712
Paraesthesia 23.26 9.64 753 234342 156213 63097714
Antisocial behaviour 23.24 9.64 16 235079 393 63253534
Tenosynovitis 23.19 9.64 11 235084 13784 63240143
Creatinine renal clearance decreased 23.14 9.64 16 235079 16292 63237635
Abortion missed 22.88 9.64 30 235065 1689 63252238
Hallucination, gustatory 22.82 9.64 9 235086 64 63253863
Mutism 22.56 9.64 29 235066 1601 63252326
Menstruation irregular 22.53 9.64 67 235028 6937 63246990
Maternal exposure during breast feeding 22.46 9.64 49 235046 4192 63249735
Complication of device removal 22.39 9.64 55 235040 5087 63248840
Mitochondrial encephalomyopathy 22.35 9.64 7 235088 22 63253905
Anaphylactic shock 22.33 9.64 33 235062 23600 63230327
Cholelithiasis 22.33 9.64 255 234840 43670 63210257
Food interaction 22.26 9.64 21 235074 817 63253110
Breast cancer stage II 22.22 9.64 3 235092 8733 63245194
Breath sounds abnormal 22.21 9.64 90 235005 10883 63243044
Bone marrow failure 22.16 9.64 47 235048 29243 63224684
Wound infection 22.14 9.64 28 235067 21382 63232545
Haematotoxicity 22.08 9.64 4 235091 9372 63244555
Sleep-related eating disorder 21.98 9.64 21 235074 830 63253097
Stress 21.87 9.64 360 234735 66807 63187120
Hypotonia neonatal 21.86 9.64 25 235070 1221 63252706
Transient psychosis 21.86 9.64 8 235087 45 63253882
Dissociation 21.86 9.64 39 235056 2880 63251047
Somatic symptom disorder 21.82 9.64 37 235058 2623 63251304
Post-traumatic stress disorder 21.64 9.64 55 235040 5196 63248731
Amniotic fluid volume increased 21.53 9.64 11 235084 152 63253775
Herbal interaction 21.42 9.64 10 235085 112 63253815
Presyncope 21.39 9.64 176 234919 27609 63226318
Right ventricular hypertrophy 21.37 9.64 19 235076 684 63253243
Nausea 21.24 9.64 3535 231560 850936 62402991
Postural orthostatic tachycardia syndrome 21.17 9.64 25 235070 1264 63252663
Impaired reasoning 21.10 9.64 9 235086 80 63253847
Adverse drug reaction 21.06 9.64 191 234904 79523 63174404
Urine sodium decreased 21.04 9.64 11 235084 160 63253767
Delusional disorder, persecutory type 20.99 9.64 12 235083 210 63253717
Blood pressure diastolic abnormal 20.99 9.64 14 235081 14528 63239399
Peripheral venous disease 20.90 9.64 16 235079 15461 63238466
Lip dry 20.88 9.64 16 235079 15454 63238473
Panic disorder 20.78 9.64 36 235059 2597 63251330
Environmental exposure 20.71 9.64 9 235086 84 63253843
Ataxia 20.69 9.64 111 234984 15084 63238843
Cataract 20.68 9.64 125 234970 56928 63196999
Small for dates baby 20.63 9.64 44 235051 3707 63250220
Hypertonia 20.61 9.64 50 235045 4587 63249340
Hypersensitivity pneumonitis 20.61 9.64 36 235059 2614 63251313
Slow response to stimuli 20.33 9.64 22 235073 1010 63252917
Neoplasm progression 20.32 9.64 68 235027 36360 63217567
Pulmonary toxicity 20.28 9.64 5 235090 9450 63244477
Haematoma muscle 20.26 9.64 23 235072 1114 63252813
Social anxiety disorder 20.21 9.64 15 235080 416 63253511
Congenital brain damage 20.09 9.64 5 235090 4 63253923
Self esteem decreased 20.08 9.64 18 235077 655 63253272
Illness anxiety disorder 19.98 9.64 10 235085 132 63253795
Dermatitis atopic 19.88 9.64 80 235015 9644 63244283
Pseudodementia 19.83 9.64 9 235086 94 63253833
Parkinsonian gait 19.83 9.64 16 235079 503 63253424
Soliloquy 19.81 9.64 12 235083 235 63253692
Collagen-vascular disease 19.75 9.64 9 235086 95 63253832
Diplopia 19.74 9.64 153 234942 23575 63230352
Tongue spasm 19.70 9.64 8 235087 62 63253865
Dislocation of vertebra 19.66 9.64 4 235091 8631 63245296
Femur-fibula-ulna complex 19.57 9.64 5 235090 5 63253922
Erythromelalgia 19.53 9.64 10 235085 139 63253788
Delusion of reference 19.42 9.64 9 235086 99 63253828
Hyponatraemic encephalopathy 19.41 9.64 12 235083 244 63253683
Dissociative disorder 19.34 9.64 14 235081 373 63253554
Hypochloraemia 19.27 9.64 30 235065 1979 63251948
Atrial septal defect 19.21 9.64 63 235032 6875 63247052
Gallbladder cholesterolosis 19.15 9.64 19 235076 787 63253140
Multiple sclerosis 19.09 9.64 155 234940 24217 63229710
Palmar-plantar erythrodysaesthesia syndrome 19.08 9.64 35 235060 22980 63230947
Cardiac murmur 18.94 9.64 105 234990 14447 63239480
Polymenorrhoea 18.94 9.64 23 235072 1198 63252729
Total lung capacity increased 18.78 9.64 32 235063 2278 63251649
Tuberculosis 18.76 9.64 9 235086 11202 63242725
Ductus arteriosus premature closure 18.75 9.64 13 235082 323 63253604
Head injury 18.71 9.64 169 234926 27227 63226700
Pneumocystis jirovecii pneumonia 18.69 9.64 21 235074 16893 63237034
Live birth 18.67 9.64 42 235053 25588 63228339
Catastrophic reaction 18.67 9.64 6 235089 21 63253906
Neutropenic sepsis 18.61 9.64 20 235075 16418 63237509
Alcohol use 18.51 9.64 30 235065 2049 63251878
Eosinophilic pneumonia 18.46 9.64 31 235064 2180 63251747
Alcohol intolerance 18.45 9.64 9 235086 112 63253815
Injection site bruising 18.43 9.64 86 235009 41824 63212103
Intracranial meningioma malignant 18.41 9.64 4 235091 0 63253927
Congenital skin dimples 18.38 9.64 9 235086 113 63253814
Heat stroke 18.34 9.64 19 235076 829 63253098
Lack of spontaneous speech 18.34 9.64 10 235085 159 63253768
Photophobia 18.33 9.64 120 234975 17515 63236412
Persistent depressive disorder 18.31 9.64 21 235074 1029 63252898
Suicide threat 18.25 9.64 6 235089 23 63253904
Negative symptoms in schizophrenia 18.24 9.64 9 235086 115 63253812
Urticaria 18.15 9.64 471 234624 165331 63088596
Water intoxication 18.11 9.64 14 235081 413 63253514
Target skin lesion 18.10 9.64 9 235086 117 63253810
Somatic delusion 18.00 9.64 16 235079 576 63253351
CYP3A4 polymorphism 17.93 9.64 8 235087 80 63253847
Unintended pregnancy 17.91 9.64 57 235038 6122 63247805
Infantile vomiting 17.90 9.64 9 235086 120 63253807
Dopamine dysregulation syndrome 17.75 9.64 10 235085 170 63253757
Bronchopulmonary aspergillosis 17.70 9.64 5 235090 8630 63245297
Hyperphagia 17.68 9.64 27 235068 1752 63252175
Pulmonary valve stenosis congenital 17.65 9.64 10 235085 172 63253755
Sluggishness 17.52 9.64 51 235044 5218 63248709
Tongue discolouration 17.44 9.64 37 235058 3106 63250821
Morning sickness 17.42 9.64 18 235077 783 63253144
Libido disorder 17.37 9.64 7 235088 53 63253874
Urine chloride decreased 17.35 9.64 8 235087 87 63253840
Dopamine transporter scintigraphy abnormal 17.35 9.64 8 235087 87 63253840
Prothrombin time ratio decreased 17.28 9.64 15 235080 523 63253404
Mitochondrial cytopathy 17.27 9.64 11 235084 236 63253691
Female orgasmic disorder 17.26 9.64 7 235088 54 63253873
Liver disorder 17.24 9.64 122 234973 53565 63200362
Blood calcium decreased 17.19 9.64 46 235049 26405 63227522
Bradycardia 17.12 9.64 373 234722 72854 63181073
Physical assault 17.01 9.64 19 235076 904 63253023
Syndactyly 17.01 9.64 14 235081 453 63253474
Epilepsy 17.00 9.64 164 234931 26901 63227026
Vanishing bile duct syndrome 16.92 9.64 17 235078 715 63253212
Prescribed overdose 16.91 9.64 67 235028 34086 63219841
Thrombotic microangiopathy 16.89 9.64 9 235086 10552 63243375
Judgement impaired 16.85 9.64 18 235077 814 63253113
Flight of ideas 16.83 9.64 14 235081 460 63253467
Delusional disorder, unspecified type 16.81 9.64 13 235082 384 63253543
Economic problem 16.79 9.64 28 235067 1958 63251969
Gastrointestinal toxicity 16.79 9.64 4 235091 7737 63246190
Tubulointerstitial nephritis 16.74 9.64 30 235065 19873 63234054
Hypokalaemia 16.70 9.64 503 234592 103301 63150626
Diaphragmatic rupture 16.68 9.64 11 235084 251 63253676
Pelvic pain 16.57 9.64 96 234999 13423 63240504
Decreased interest 16.56 9.64 37 235058 3217 63250710
Blood pressure fluctuation 16.51 9.64 102 234993 46215 63207712
Hepatic function abnormal 16.46 9.64 76 235019 37066 63216861
Dysphoria 16.45 9.64 48 235047 4918 63249009
Action tremor 16.41 9.64 12 235083 325 63253602
Visceral congestion 16.31 9.64 12 235083 328 63253599
Muscle contracture 16.31 9.64 23 235072 1388 63252539
Feeling guilty 16.26 9.64 15 235080 567 63253360
Electrocardiogram T wave abnormal 16.19 9.64 31 235064 2416 63251511
Glucose tolerance impaired in pregnancy 16.18 9.64 4 235091 3 63253924
Myocardial fibrosis 16.17 9.64 17 235078 755 63253172
Gallbladder injury 16.16 9.64 23 235072 1400 63252527
Biliary dyskinesia 16.16 9.64 33 235062 2696 63251231
Phalangeal hypoplasia 16.14 9.64 5 235090 15 63253912
Compulsions 16.10 9.64 10 235085 205 63253722
Aphasia 16.07 9.64 190 234905 32810 63221117
Teratoma benign 16.05 9.64 7 235088 66 63253861
Product taste abnormal 15.97 9.64 28 235067 2039 63251888
Oral discomfort 15.95 9.64 72 235023 9129 63244798
Feeling of despair 15.93 9.64 30 235065 2309 63251618
Petit mal epilepsy 15.90 9.64 40 235055 3754 63250173
Ear infection 15.89 9.64 80 235015 38133 63215794
Behaviour disorder 15.86 9.64 36 235059 3163 63250764
Postmortem blood drug level increased 15.78 9.64 15 235080 589 63253338
Injection site pruritus 15.75 9.64 100 234995 45016 63208911
Cough 15.74 9.64 905 234190 291838 62962089
Communication disorder 15.72 9.64 31 235064 2469 63251458
Alkalosis hypochloraemic 15.72 9.64 9 235086 158 63253769
Metastases to bone 15.68 9.64 34 235061 20985 63232942
Drug hypersensitivity 15.68 9.64 1345 233750 309342 62944585
Marital problem 15.67 9.64 9 235086 159 63253768
Neonatal seizure 15.65 9.64 14 235081 508 63253419
Ophthalmic vein thrombosis 15.64 9.64 10 235085 216 63253711
Atrioventricular dissociation 15.64 9.64 10 235085 216 63253711
Distractibility 15.53 9.64 13 235082 431 63253496
Claustrophobia 15.50 9.64 19 235076 999 63252928
Pre-eclampsia 15.48 9.64 71 235024 9062 63244865
Attention-seeking behaviour 15.43 9.64 7 235088 73 63253854
Screaming 15.39 9.64 36 235059 3226 63250701
Morbid thoughts 15.39 9.64 15 235080 608 63253319
Macular degeneration 15.38 9.64 43 235052 24333 63229594
Gambling disorder 15.36 9.64 21 235074 1231 63252696
Cardiotoxicity 15.35 9.64 6 235089 8432 63245495
Infantile apnoea 15.28 9.64 19 235076 1014 63252913
Nephropathy toxic 15.27 9.64 8 235087 9471 63244456
Snoring 15.27 9.64 42 235053 4160 63249767
Spleen congestion 15.26 9.64 8 235087 117 63253810
Exposure during pregnancy 15.18 9.64 713 234382 154834 63099093
Suspiciousness 15.16 9.64 12 235083 367 63253560
Drug reaction with eosinophilia and systemic symptoms 15.14 9.64 69 235026 33767 63220160
Accommodation disorder 15.10 9.64 12 235083 369 63253558
Embolic cerebellar infarction 15.04 9.64 5 235090 20 63253907
Fear of weight gain 15.04 9.64 5 235090 20 63253907
Suspected suicide 15.03 9.64 56 235039 6512 63247415
Metastases to lung 15.02 9.64 15 235080 12735 63241192
Leukaemoid reaction 14.96 9.64 9 235086 174 63253753
Affect lability 14.87 9.64 81 235014 11070 63242857
Asocial behaviour 14.85 9.64 5 235090 21 63253906
Product odour abnormal 14.80 9.64 21 235074 1275 63252652
Renal dysplasia 14.80 9.64 10 235085 238 63253689
Transplant rejection 14.74 9.64 11 235084 10769 63243158
Abnormal uterine bleeding 14.71 9.64 23 235072 1523 63252404
Diverticulitis 14.69 9.64 86 235009 39471 63214456
Genital hypoaesthesia 14.66 9.64 5 235090 22 63253905
Blood test abnormal 14.60 9.64 22 235073 15607 63238320
Rectal cancer metastatic 14.51 9.64 10 235085 246 63253681
Psychogenic seizure 14.50 9.64 24 235071 1668 63252259
May-Thurner syndrome 14.48 9.64 5 235090 23 63253904
Coma scale abnormal 14.45 9.64 47 235048 5106 63248821
Derealisation 14.43 9.64 20 235075 1188 63252739
Heart rate decreased 14.40 9.64 104 234991 45456 63208471
Menopausal disorder 14.40 9.64 6 235089 50 63253877
Asphyxia 14.39 9.64 53 235042 6128 63247799
Blood pressure systolic abnormal 14.38 9.64 17 235078 13369 63240558
Peritonitis 14.30 9.64 26 235069 17128 63236799
Reflexes abnormal 14.27 9.64 15 235080 666 63253261
Hypercapnic coma 14.26 9.64 9 235086 190 63253737
Postpartum haemorrhage 14.24 9.64 26 235069 1955 63251972
Aplastic anaemia 14.10 9.64 9 235086 9560 63244367
Athetosis 14.10 9.64 6 235089 53 63253874
Gross motor delay 14.10 9.64 8 235087 138 63253789
Drug resistance 14.07 9.64 41 235054 22892 63231035
Serum serotonin increased 14.02 9.64 9 235086 196 63253731
Temporomandibular joint syndrome 14.00 9.64 40 235055 4049 63249878
Vasodilation procedure 13.99 9.64 5 235090 26 63253901
Blood creatinine increased 13.90 9.64 235 234860 87609 63166318
Localised infection 13.88 9.64 61 235034 30149 63223778
Congenital tricuspid valve incompetence 13.82 9.64 7 235088 95 63253832
Postictal headache 13.81 9.64 3 235092 0 63253927
Long-chain acyl-coenzyme A dehydrogenase deficiency 13.81 9.64 3 235092 0 63253927
Anaplastic large cell lymphoma T- and null-cell types stage IV 13.81 9.64 3 235092 0 63253927
Neonatal tachypnoea 13.80 9.64 8 235087 144 63253783
Skin reaction 13.77 9.64 21 235074 14828 63239099
Pulmonary infarction 13.72 9.64 31 235064 2716 63251211
Energy increased 13.72 9.64 31 235064 2716 63251211
Laryngomalacia 13.72 9.64 6 235089 57 63253870
Purple glove syndrome 13.70 9.64 9 235086 204 63253723
Feeling drunk 13.68 9.64 40 235055 4102 63249825
Opisthotonus 13.66 9.64 11 235084 345 63253582
Dysphagia 13.64 9.64 427 234668 88158 63165769
Exposure via breast milk 13.54 9.64 26 235069 2031 63251896
Partner stress 13.50 9.64 12 235083 432 63253495
Panic reaction 13.49 9.64 40 235055 4134 63249793
Swelling face 13.49 9.64 319 234776 63156 63190771
Pseudomonas infection 13.43 9.64 13 235082 11200 63242727
Generalised anxiety disorder 13.39 9.64 26 235069 2048 63251879
Belligerence 13.37 9.64 8 235087 153 63253774
Joint hyperextension 13.36 9.64 11 235084 356 63253571
Gaze palsy 13.34 9.64 21 235074 1399 63252528
Cognitive disorder 13.27 9.64 285 234810 55530 63198397
Alice in wonderland syndrome 13.26 9.64 5 235090 31 63253896
Ventricular septal defect 13.26 9.64 41 235054 4337 63249590
Parakeratosis 13.24 9.64 10 235085 285 63253642
Bone density decreased 13.23 9.64 21 235074 14591 63239336
Gait deviation 13.19 9.64 6 235089 63 63253864
Oral candidiasis 13.10 9.64 42 235053 22756 63231171
Seizure like phenomena 13.09 9.64 18 235077 1061 63252866
Polyarthritis 13.06 9.64 11 235084 10135 63243792
Joint stiffness 13.03 9.64 96 234999 41773 63212154
Stupor 12.91 9.64 40 235055 4235 63249692
Mite allergy 12.88 9.64 14 235081 646 63253281
Akinesia 12.86 9.64 22 235073 1571 63252356
Personality disorder 12.84 9.64 49 235046 5762 63248165
Sinus tachycardia 12.84 9.64 142 234953 24126 63229801
Subchorionic haemorrhage 12.84 9.64 8 235087 165 63253762
Large intestine polyp 12.79 9.64 62 235033 8095 63245832
Phospholipidosis 12.75 9.64 8 235087 167 63253760
Female genital tract fistula 12.75 9.64 6 235089 7553 63246374
Neoplasm malignant 12.71 9.64 62 235033 29799 63224128
Lip blister 12.71 9.64 28 235067 2412 63251515
Disinhibition 12.68 9.64 16 235079 867 63253060
Urinary hesitation 12.67 9.64 27 235068 2273 63251654
Proteinuria 12.66 9.64 33 235062 19112 63234815
Drug clearance decreased 12.65 9.64 21 235074 1463 63252464
CSF glucose decreased 12.64 9.64 6 235089 70 63253857
Pathogen resistance 12.58 9.64 4 235091 6394 63247533
Cytokine release syndrome 12.56 9.64 21 235074 14293 63239634
Vanishing twin syndrome 12.53 9.64 7 235088 117 63253810
Fluid retention 12.50 9.64 151 234944 59535 63194392
Retching 12.50 9.64 95 235000 14550 63239377
Device material issue 12.49 9.64 9 235086 238 63253689
Attention deficit hyperactivity disorder 12.45 9.64 32 235063 3044 63250883
Implant site irritation 12.43 9.64 8 235087 175 63253752
Pulmonary valve incompetence 12.37 9.64 20 235075 1363 63252564
Delusional perception 12.36 9.64 9 235086 242 63253685
Cerebellar hypoplasia 12.27 9.64 7 235088 122 63253805
Amnestic disorder 12.27 9.64 10 235085 319 63253608
Glomerulonephritis minimal lesion 12.24 9.64 9 235086 246 63253681
Serositis 12.22 9.64 14 235081 685 63253242
Osteonecrosis of jaw 12.18 9.64 78 235017 35045 63218882
Overweight 12.18 9.64 36 235059 3715 63250212
Trance 12.17 9.64 5 235090 40 63253887
Staphylococcal scalded skin syndrome 12.17 9.64 7 235088 124 63253803
Negativism 12.14 9.64 11 235084 406 63253521
Tendonitis 12.08 9.64 35 235060 19580 63234347
Hypoosmolar state 12.08 9.64 8 235087 184 63253743
Granulocytopenia neonatal 12.03 9.64 4 235091 16 63253911
Crime 12.03 9.64 4 235091 16 63253911
Congenital hydronephrosis 12.03 9.64 11 235084 411 63253516
Orthostatic hypertension 11.92 9.64 12 235083 506 63253421
Reduced facial expression 11.91 9.64 24 235071 1942 63251985
Lipidosis 11.86 9.64 5 235090 43 63253884
Immunodeficiency 11.86 9.64 37 235058 20217 63233710
Loss of personal independence in daily activities 11.84 9.64 272 234823 97018 63156909
Neurosis 11.84 9.64 9 235086 259 63253668
Trichotillomania 11.83 9.64 7 235088 131 63253796
Dyspraxia 11.78 9.64 9 235086 261 63253666
Disease recurrence 11.77 9.64 157 234938 27873 63226054
Female sexual dysfunction 11.76 9.64 5 235090 44 63253883
Orgasm abnormal 11.74 9.64 6 235089 83 63253844
Boredom 11.74 9.64 3 235092 3 63253924
Pityriasis 11.74 9.64 3 235092 3 63253924
Enuresis 11.71 9.64 28 235067 2545 63251382
Postural tremor 11.70 9.64 10 235085 341 63253586
Injection site swelling 11.70 9.64 116 234979 47456 63206471
Obsessive-compulsive personality disorder 11.66 9.64 4 235091 18 63253909
Dental caries 11.60 9.64 74 235021 10705 63243222
Increased appetite 11.56 9.64 68 235027 9562 63244365
Anal incontinence 11.55 9.64 88 235007 13488 63240439
Hostility 11.52 9.64 23 235072 1849 63252078
Exposure via ingestion 11.50 9.64 30 235065 2879 63251048
Maternal condition affecting foetus 11.50 9.64 8 235087 200 63253727
Drug monitoring procedure incorrectly performed 11.50 9.64 8 235087 200 63253727
Serum serotonin decreased 11.48 9.64 4 235091 19 63253908
Tachypnoea 11.44 9.64 106 234989 17196 63236731
Skin ulcer 11.43 9.64 103 234992 42942 63210985
Facial paralysis 11.38 9.64 90 235005 13951 63239976
Interstitial lung disease 11.36 9.64 161 234934 61747 63192180
Dyspnoea exertional 11.36 9.64 156 234939 60146 63193781
Drug-device interaction 11.31 9.64 6 235089 90 63253837
Lactate pyruvate ratio increased 11.31 9.64 6 235089 90 63253837
Headache 11.25 9.64 2577 232518 630664 62623263
Neurological examination abnormal 11.21 9.64 9 235086 281 63253646
Polymenorrhagia 11.21 9.64 5 235090 50 63253877
Blood prolactin decreased 11.21 9.64 5 235090 50 63253877
Death of relative 11.18 9.64 9 235086 282 63253645
Narcotic bowel syndrome 11.17 9.64 7 235088 146 63253781
Shared psychotic disorder 11.16 9.64 4 235091 21 63253906
Joint injury 11.14 9.64 64 235031 29508 63224419
Skin burning sensation 11.09 9.64 83 235012 12651 63241276
Sinoatrial block 11.05 9.64 15 235080 873 63253054
Transfusion 11.03 9.64 25 235070 15192 63238735
Menopause 11.03 9.64 29 235066 2796 63251131
Myoclonic epilepsy 11.03 9.64 18 235077 1236 63252691
Dependence 11.00 9.64 24 235071 2053 63251874
Breast discharge 10.98 9.64 16 235079 995 63252932
Rash maculo-papular 10.98 9.64 71 235024 31825 63222102
Meconium in amniotic fluid 10.97 9.64 9 235086 290 63253637
Pelvic inflammatory disease 10.93 9.64 21 235074 1641 63252286
Phalangeal agenesis 10.87 9.64 5 235090 54 63253873
Cardiac septal defect 10.86 9.64 9 235086 294 63253633
Muscle contractions involuntary 10.86 9.64 26 235069 2366 63251561
Coprolalia 10.86 9.64 4 235091 23 63253904
Implant site rash 10.84 9.64 7 235088 154 63253773
Breast cancer stage I 10.83 9.64 6 235089 6883 63247044
Cardio-respiratory distress 10.80 9.64 7 235088 155 63253772
Neonatal disorder 10.74 9.64 12 235083 571 63253356
Sensory disturbance 10.73 9.64 87 235008 13585 63240342
Neonatal respiratory distress 10.69 9.64 10 235085 385 63253542
Gynaecomastia 10.65 9.64 8 235087 226 63253701
Febrile bone marrow aplasia 10.64 9.64 7 235088 7318 63246609
Paralysis recurrent laryngeal nerve 10.63 9.64 5 235090 57 63253870
Decreased activity 10.61 9.64 49 235046 6271 63247656
Weight increased 10.61 9.64 1112 233983 259680 62994247
Faeces discoloured 10.58 9.64 110 234985 18399 63235528
Product substitution error 10.58 9.64 4 235091 25 63253902
Sinus bradycardia 10.58 9.64 91 235004 14460 63239467
Polyneuropathy 10.55 9.64 24 235071 14565 63239362
Musculoskeletal disorder 10.54 9.64 40 235055 20604 63233323
Bladder cyst 10.53 9.64 3 235092 6 63253921
Red blood cell sedimentation rate increased 10.51 9.64 108 234987 43874 63210053
Blood citric acid increased 10.48 9.64 5 235090 59 63253868
Psychotic behaviour 10.46 9.64 12 235083 588 63253339
Arrested labour 10.44 9.64 8 235087 233 63253694
Dementia Alzheimer's type 10.41 9.64 16 235079 1044 63252883
Visual field defect 10.38 9.64 50 235045 6511 63247416
Breast discomfort 10.36 9.64 11 235084 494 63253433
Hypertonia neonatal 10.35 9.64 8 235087 236 63253691
Deprescribing error 10.32 9.64 4 235091 27 63253900
Metastases to lymph nodes 10.31 9.64 9 235086 8149 63245778
Cytomegalovirus viraemia 10.30 9.64 4 235091 5645 63248282
Medication overuse headache 10.28 9.64 14 235081 818 63253109
Acute myeloid leukaemia 10.27 9.64 31 235064 17116 63236811
Chronic kidney disease 10.23 9.64 113 234982 45285 63208642
Monocyte percentage decreased 10.21 9.64 8 235087 241 63253686
Food craving 10.21 9.64 20 235075 1586 63252341
Central nervous system lupus 10.20 9.64 11 235084 503 63253424
Ascites 10.15 9.64 99 234996 40629 63213298
Hypnopompic hallucination 10.13 9.64 5 235090 64 63253863
Dizziness postural 10.12 9.64 54 235041 7322 63246605
Tumour lysis syndrome 10.11 9.64 11 235084 8979 63244948
Foot deformity 10.11 9.64 61 235034 27792 63226135
Pharyngeal oedema 10.07 9.64 86 235009 13635 63240292
Mesenteric panniculitis 10.06 9.64 6 235089 114 63253813
Dependent personality disorder 10.06 9.64 5 235090 65 63253862
Body mass index increased 10.05 9.64 17 235078 1203 63252724
Cholestasis of pregnancy 10.00 9.64 17 235078 1208 63252719
Polydipsia psychogenic 9.99 9.64 5 235090 66 63253861
Cushingoid 9.97 9.64 10 235085 8475 63245452
Dissociative amnesia 9.96 9.64 4 235091 30 63253897
Congenital anomaly 9.96 9.64 21 235074 1755 63252172
Breast enlargement 9.95 9.64 20 235075 1616 63252311
Impaired driving ability 9.94 9.64 38 235057 4473 63249454
Congenital nystagmus 9.94 9.64 3 235092 8 63253919
Analgesic drug level increased 9.93 9.64 25 235070 2347 63251580
Amyloid related imaging abnormality-microhaemorrhages and haemosiderin deposits 9.92 9.64 5 235090 67 63253860
Lower limb fracture 9.90 9.64 51 235044 24170 63229757
Breast pain 9.84 9.64 61 235034 8737 63245190
Prescription drug used without a prescription 9.84 9.64 25 235070 2361 63251566
Neurological symptom 9.83 9.64 45 235050 5738 63248189
Right ventricular dilatation 9.81 9.64 18 235077 1358 63252569
Distributive shock 9.75 9.64 18 235077 1365 63252562
C-reactive protein 9.69 9.64 3 235092 4879 63249048
Symptom recurrence 9.69 9.64 21 235074 1789 63252138
Pancreatic enzymes decreased 9.68 9.64 3 235092 9 63253918
Haematotympanum 9.68 9.64 3 235092 9 63253918
Disseminated intravascular coagulation 9.67 9.64 37 235058 19014 63234913

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Depression 970.48 10.47 1390 114466 95708 34745367
Serotonin syndrome 738.52 10.47 576 115280 19357 34821718
Drug interaction 679.15 10.47 1958 113898 223988 34617087
Suicidal ideation 648.79 10.47 733 115123 39655 34801420
Intentional self-injury 448.30 10.47 369 115487 13402 34827673
Suicide attempt 345.22 10.47 529 115327 38587 34802488
Anxiety 336.21 10.47 901 114955 98527 34742548
Intentional overdose 325.66 10.47 547 115309 43127 34797948
Completed suicide 317.31 10.47 875 114981 97293 34743782
Drug abuse 242.52 10.47 801 115055 98295 34742780
Paranoia 216 10.47 232 115624 11836 34829239
Foetal exposure during pregnancy 206.60 10.47 416 115440 37685 34803390
Tremor 205.97 10.47 672 115184 81915 34759160
Agitation 205.84 10.47 532 115324 56867 34784208
Irritability 197.09 10.47 319 115537 24371 34816704
Aggression 190.84 10.47 408 115448 38556 34802519
Pyrexia 190.81 10.47 524 115332 332489 34508586
Agitation neonatal 180.36 10.47 83 115773 1013 34840062
Psychotic disorder 157.15 10.47 287 115569 24165 34816910
Maternal exposure during pregnancy 143.96 10.47 124 115732 4794 34836281
Somnolence 141.78 10.47 735 115121 110381 34730694
Atrial septal defect 139.17 10.47 146 115710 7246 34833829
Respiratory disorder neonatal 138.35 10.47 79 115777 1551 34839524
Toxicity to various agents 136.79 10.47 1132 114724 199230 34641845
Febrile neutropenia 135.78 10.47 152 115704 136697 34704378
Psychiatric decompensation 131.20 10.47 95 115761 2842 34838233
Withdrawal syndrome 130.88 10.47 183 115673 12272 34828803
Priapism 130.37 10.47 118 115738 4876 34836199
Overdose 128.62 10.47 620 115236 90439 34750636
Sopor 128.55 10.47 179 115677 11957 34829118
Dyskinesia 126.60 10.47 249 115607 22164 34818911
Tearfulness 125.41 10.47 89 115767 2578 34838497
Erectile dysfunction 118.66 10.47 231 115625 20406 34820669
Confusional state 118.05 10.47 850 115006 143310 34697765
Parkinsonism 117.59 10.47 140 115716 7998 34833077
Loss of personal independence in daily activities 116.28 10.47 305 115551 32874 34808201
Depressive symptom 115.40 10.47 87 115769 2772 34838303
Acute kidney injury 114.54 10.47 571 115285 304417 34536658
Drug withdrawal syndrome neonatal 109.50 10.47 93 115763 3526 34837549
Anger 109.39 10.47 164 115692 11720 34829355
Off label use 109.01 10.47 880 114976 418644 34422431
Pneumonia 103.41 10.47 741 115115 361886 34479189
Hallucination, auditory 103.40 10.47 160 115696 11757 34829318
Depression suicidal 102.82 10.47 77 115779 2428 34838647
Sexual dysfunction 102.08 10.47 115 115741 6188 34834887
Obsessive-compulsive disorder 101.37 10.47 108 115748 5456 34835619
Malignant neoplasm progression 97.30 10.47 89 115767 87957 34753118
Loss of libido 97.16 10.47 75 115781 2477 34838598
Drug withdrawal syndrome 96.27 10.47 207 115649 19627 34821448
Hypomania 95.69 10.47 72 115784 2287 34838788
Sepsis 95.13 10.47 262 115594 166299 34674776
Delusion 93.74 10.47 158 115698 12477 34828598
Blepharospasm 93.50 10.47 54 115802 1084 34839991
Mania 92.94 10.47 135 115721 9376 34831699
Psychomotor skills impaired 87.93 10.47 85 115771 3821 34837254
Exposure during pregnancy 87.57 10.47 127 115729 8807 34832268
Restlessness 86.99 10.47 232 115624 25250 34815825
Insomnia 86.33 10.47 615 115241 103292 34737783
Tachyphrenia 85.51 10.47 53 115803 1216 34839859
Intrusive thoughts 85.48 10.47 34 115822 281 34840794
Anaemia 85.12 10.47 441 115415 232894 34608181
Pancytopenia 83.53 10.47 116 115740 95041 34746034
Akathisia 83.49 10.47 118 115738 7991 34833084
Homicidal ideation 83.36 10.47 70 115786 2612 34838463
Extrapyramidal disorder 82.51 10.47 151 115705 12729 34828346
Hallucination 81.01 10.47 362 115494 51136 34789939
Disease progression 80.46 10.47 147 115709 107930 34733145
Hallucination, visual 78.80 10.47 179 115677 17612 34823463
Sedation 78.65 10.47 198 115658 20808 34820267
Dystonia 78.32 10.47 134 115722 10711 34830364
Neutropenia 77.81 10.47 263 115593 156515 34684560
Abnormal behaviour 75.99 10.47 218 115638 24751 34816324
Thrombocytopenia 75.59 10.47 265 115591 155982 34685093
Anorgasmia 73.99 10.47 42 115814 815 34840260
Derealisation 73.34 10.47 37 115819 560 34840515
Mood swings 72.66 10.47 109 115747 7792 34833283
Catatonia 71.86 10.47 86 115770 4939 34836136
Neuroleptic malignant syndrome 68.14 10.47 170 115686 17764 34823311
Major depression 66.62 10.47 79 115777 4493 34836582
Hypertonia neonatal 66.48 10.47 32 115824 435 34840640
Renal impairment 66.45 10.47 133 115723 94380 34746695
Bradykinesia 62.99 10.47 71 115785 3822 34837253
Obsessive thoughts 62.50 10.47 36 115820 719 34840356
Patent ductus arteriosus 60.92 10.47 65 115791 3289 34837786
Treatment noncompliance 60.61 10.47 218 115638 27882 34813193
Feeling jittery 59.71 10.47 70 115786 3933 34837142
Septic shock 59.65 10.47 91 115765 71743 34769332
Rash 59.57 10.47 463 115393 222289 34618786
Cytomegalovirus infection 57.27 10.47 9 115847 26126 34814949
Blood prolactin increased 56.91 10.47 47 115809 1713 34839362
Ventricular septal defect 56.44 10.47 68 115788 3933 34837142
Tic 56.43 10.47 50 115806 2008 34839067
Amnesia 56.37 10.47 205 115651 26358 34814717
Neuropathy peripheral 55.30 10.47 121 115735 83142 34757933
Head discomfort 54.89 10.47 68 115788 4048 34837027
Small for dates baby 54.18 10.47 66 115790 3861 34837214
Bradyphrenia 54.17 10.47 73 115783 4725 34836350
General physical health deterioration 54.00 10.47 230 115626 128039 34713036
Large for dates baby 53.54 10.47 35 115821 883 34840192
Depressed mood 53.39 10.47 163 115693 19154 34821921
Nightmare 53.19 10.47 135 115721 14256 34826819
Prostate cancer 52.85 10.47 33 115823 39616 34801459
Hyperhidrosis 52.72 10.47 430 115426 75262 34765813
Ascites 52.71 10.47 46 115810 46525 34794550
Fall 52.46 10.47 954 114902 201931 34639144
Psychomotor hyperactivity 52.04 10.47 105 115751 9517 34831558
Apathy 51.84 10.47 87 115769 6845 34834230
Infusion related reaction 51.39 10.47 60 115796 52997 34788078
Neonatal respiratory distress syndrome 51.17 10.47 65 115791 3969 34837106
Seizure 51.12 10.47 552 115304 104305 34736770
Colitis microscopic 51.00 10.47 50 115806 2287 34838788
Homicide 50.09 10.47 34 115822 915 34840160
Genital hypoaesthesia 49.31 10.47 21 115835 210 34840865
Prescribed overdose 49.25 10.47 109 115747 10538 34830537
Social avoidant behaviour 49.04 10.47 56 115800 3058 34838017
Psychomotor retardation 48.19 10.47 60 115796 3590 34837485
Dyspnoea 47.52 10.47 922 114934 375860 34465215
Maternal exposure during breast feeding 47.44 10.47 40 115816 1501 34839574
Bruxism 47.27 10.47 42 115814 1693 34839382
Interstitial lung disease 46.62 10.47 91 115765 65191 34775884
Thinking abnormal 45.86 10.47 77 115779 6060 34835015
Pleural effusion 45.21 10.47 130 115726 81416 34759659
Disturbance in attention 45.09 10.47 188 115668 25757 34815318
Muscle rigidity 44.56 10.47 104 115752 10414 34830661
Oromandibular dystonia 44.46 10.47 25 115831 476 34840599
Electrocardiogram QT prolonged 44.16 10.47 259 115597 40693 34800382
Feeling abnormal 43.90 10.47 359 115497 62876 34778199
Haemangioma congenital 43.68 10.47 25 115831 493 34840582
Cogwheel rigidity 43.50 10.47 36 115820 1316 34839759
Bipolar disorder 43.23 10.47 57 115799 3612 34837463
Pneumocystis jirovecii pneumonia 42.70 10.47 7 115849 19703 34821372
Diarrhoea 42.47 10.47 977 114879 388935 34452140
Libido decreased 42.07 10.47 64 115792 4632 34836443
Restless legs syndrome 41.46 10.47 88 115768 8266 34832809
Myelosuppression 41.39 10.47 7 115849 19258 34821817
Fever neonatal 41.28 10.47 10 115846 8 34841067
Arthralgia 41.06 10.47 363 115493 169678 34671397
Panic attack 40.77 10.47 94 115762 9338 34831737
Speech disorder 40.70 10.47 181 115675 25505 34815570
Platelet count decreased 40.39 10.47 232 115624 119485 34721590
Cardiac failure 40.01 10.47 161 115695 91087 34749988
Persecutory delusion 39.96 10.47 46 115810 2534 34838541
C-reactive protein increased 39.86 10.47 74 115782 54024 34787051
Blood creatine phosphokinase increased 39.84 10.47 270 115586 44587 34796488
Resting tremor 39.77 10.47 26 115830 656 34840419
Neonatal respiratory distress 39.52 10.47 25 115831 595 34840480
Bone marrow failure 39.47 10.47 24 115832 29229 34811846
Renal failure 39.38 10.47 262 115594 130295 34710780
Loss of consciousness 39.27 10.47 433 115423 82234 34758841
Sleep disorder 39.21 10.47 208 115648 31480 34809595
Oesophageal pain 39.15 10.47 28 115828 821 34840254
Myoclonus 38.61 10.47 122 115734 14603 34826472
Overweight 38.59 10.47 39 115817 1851 34839224
Depersonalisation/derealisation disorder 37.99 10.47 24 115832 570 34840505
Hepatic function abnormal 37.99 10.47 55 115801 44308 34796767
Antipsychotic drug level increased 37.96 10.47 55 115801 3810 34837265
Apgar score low 37.83 10.47 28 115828 867 34840208
Antidepressant drug level increased 37.81 10.47 15 115841 123 34840952
Anhedonia 37.76 10.47 80 115776 7505 34833570
Product substitution issue 37.62 10.47 95 115761 10000 34831075
Erythema 37.46 10.47 159 115697 88621 34752454
Mucosal inflammation 37.05 10.47 44 115812 38578 34802497
Inappropriate antidiuretic hormone secretion 36.55 10.47 109 115747 12644 34828431
Death 36.46 10.47 1023 114833 397026 34444049
Drug dependence 36.39 10.47 168 115688 24049 34817026
Rheumatoid arthritis 36.21 10.47 44 115812 38194 34802881
Poisoning deliberate 35.93 10.47 80 115776 7764 34833311
Ejaculation failure 35.75 10.47 26 115830 783 34840292
Foaming at mouth 35.32 10.47 26 115830 798 34840277
COVID-19 35.16 10.47 135 115721 77415 34763660
Premature ejaculation 34.96 10.47 14 115842 118 34840957
Tumour lysis syndrome 34.93 10.47 7 115849 17052 34824023
Drug level increased 34.48 10.47 155 115701 21941 34819134
Ideas of reference 34.28 10.47 11 115845 44 34841031
Pressure of speech 34.18 10.47 21 115835 474 34840601
Infantile apnoea 33.90 10.47 27 115829 934 34840141
Hyponatraemia 33.88 10.47 421 115435 82270 34758805
Semen discolouration 33.64 10.47 9 115847 15 34841060
Alcoholism 33.30 10.47 45 115811 2920 34838155
Morose 33.25 10.47 8 115848 6 34841069
Blood creatinine increased 33.14 10.47 182 115674 94794 34746281
Multiple organ dysfunction syndrome 32.99 10.47 136 115720 76430 34764645
Parkinsonism hyperpyrexia syndrome 32.77 10.47 12 115844 77 34840998
Muscle strain 32.57 10.47 52 115804 3924 34837151
Stomatitis 32.35 10.47 57 115799 42457 34798618
Dysphoria 32.26 10.47 39 115817 2263 34838812
Pneumonitis 32.06 10.47 39 115817 33839 34807236
Pulmonary artery stenosis 31.79 10.47 17 115839 292 34840783
Torticollis 31.57 10.47 28 115828 1126 34839949
Drug screen positive 31.52 10.47 51 115805 3892 34837183
Bradycardia neonatal 31.43 10.47 26 115830 950 34840125
Trismus 31.33 10.47 40 115816 2455 34838620
Dystonic tremor 31.15 10.47 15 115841 204 34840871
Platelet aggregation abnormal 30.80 10.47 9 115847 24 34841051
Meconium aspiration syndrome 30.78 10.47 10 115846 42 34841033
Suicidal behaviour 30.77 10.47 31 115825 1466 34839609
Delusion of replacement 30.70 10.47 13 115843 128 34840947
Acute psychosis 30.48 10.47 34 115822 1809 34839266
Muscle twitching 30.45 10.47 89 115767 10209 34830866
Generalised tonic-clonic seizure 30.43 10.47 145 115711 21029 34820046
Persistent depressive disorder 30.22 10.47 17 115839 324 34840751
Tremor neonatal 30.20 10.47 18 115838 384 34840691
Personality change 30.11 10.47 58 115798 5081 34835994
White blood cell count decreased 30.06 10.47 189 115667 95256 34745819
Male sexual dysfunction 29.85 10.47 16 115840 276 34840799
Bipolar I disorder 29.68 10.47 23 115833 764 34840311
Middle insomnia 29.63 10.47 68 115788 6734 34834341
Drug reaction with eosinophilia and systemic symptoms 29.18 10.47 40 115816 32972 34808103
Cytokine release syndrome 29.18 10.47 20 115836 22857 34818218
Dermatillomania 29.06 10.47 10 115846 52 34841023
Peripheral swelling 28.76 10.47 143 115713 76398 34764677
Tardive dyskinesia 28.74 10.47 61 115795 5729 34835346
Schizophrenia 28.66 10.47 78 115778 8588 34832487
Maternal drugs affecting foetus 28.64 10.47 49 115807 3916 34837159
Neonatal respiratory acidosis 28.59 10.47 10 115846 55 34841020
Hyporesponsive to stimuli 28.56 10.47 26 115830 1082 34839993
Disorientation 28.42 10.47 198 115658 32990 34808085
Basal cell carcinoma 28.13 10.47 15 115841 19643 34821432
Grandiosity 28.11 10.47 16 115840 312 34840763
Urticaria 28.01 10.47 109 115747 62268 34778807
Orthostatic hypotension 27.98 10.47 164 115692 25755 34815320
Lymphadenopathy 27.76 10.47 32 115824 28431 34812644
Neonatal behavioural syndrome 27.66 10.47 12 115844 126 34840949
Neonatal respiratory arrest 27.20 10.47 8 115848 22 34841053
Dementia with Lewy bodies 27.19 10.47 21 115835 694 34840381
Negativism 26.97 10.47 17 115839 402 34840673
Cardiogenic shock 26.97 10.47 29 115827 26589 34814486
Mydriasis 26.85 10.47 68 115788 7169 34833906
Nasopharyngitis 26.70 10.47 130 115726 69838 34771237
Persistent foetal circulation 26.53 10.47 16 115840 349 34840726
Affective disorder 26.52 10.47 50 115806 4310 34836765
Neutrophil count decreased 26.50 10.47 84 115772 51020 34790055
Dissociation 26.42 10.47 30 115826 1628 34839447
Inflammation 26.33 10.47 33 115823 28262 34812813
Agitated depression 26.15 10.47 14 115842 241 34840834
Phospholipidosis 26.12 10.47 9 115847 47 34841028
Impulsive behaviour 26.11 10.47 34 115822 2128 34838947
Male orgasmic disorder 25.92 10.47 11 115845 109 34840966
Oedema peripheral 25.40 10.47 264 115592 119548 34721527
Self esteem decreased 25.37 10.47 18 115838 521 34840554
Haemoglobin decreased 25.24 10.47 267 115589 120505 34720570
Exposure via breast milk 24.88 10.47 32 115824 1978 34839097
Mental disorder 24.72 10.47 108 115748 15101 34825974
Macrophages increased 24.62 10.47 12 115844 168 34840907
Synovitis 24.52 10.47 8 115848 14058 34827017
Bronchopulmonary aspergillosis 24.42 10.47 9 115847 14650 34826425
Orgasm abnormal 24.36 10.47 11 115845 128 34840947
Gastrointestinal motility disorder 24.26 10.47 36 115820 2548 34838527
Myelodysplastic syndrome 24.22 10.47 17 115839 19191 34821884
Atrial fibrillation 24.22 10.47 274 115582 122119 34718956
Post concussion syndrome 24.21 10.47 11 115845 130 34840945
Joint swelling 24.19 10.47 109 115747 59781 34781294
Radiologically isolated syndrome 24.14 10.47 6 115850 6 34841069
Dysphemia 23.97 10.47 28 115828 1567 34839508
Anorectal discomfort 23.90 10.47 31 115825 1933 34839142
Arthritis 23.87 10.47 42 115814 31304 34809771
Hypertonia 23.76 10.47 47 115809 4199 34836876
Hyperkalaemia 23.64 10.47 134 115722 69255 34771820
Balance disorder 23.63 10.47 222 115634 40432 34800643
Neonatal anoxia 23.56 10.47 5 115851 0 34841075
Hepatotoxicity 23.38 10.47 22 115834 21463 34819612
Maternal exposure timing unspecified 23.31 10.47 15 115841 368 34840707
Excessive masturbation 23.05 10.47 10 115846 105 34840970
Coma 22.94 10.47 242 115614 45436 34795639
Generalised anxiety disorder 22.81 10.47 20 115836 792 34840283
Leukopenia 22.72 10.47 119 115737 62737 34778338
Treatment failure 22.67 10.47 79 115777 46618 34794457
Hypotonia neonatal 22.57 10.47 25 115831 1320 34839755
Congenital hydronephrosis 22.51 10.47 19 115837 714 34840361
Weight decrease neonatal 22.44 10.47 14 115842 325 34840750
Graft versus host disease 22.35 10.47 4 115852 10565 34830510
Negative thoughts 22.34 10.47 18 115838 633 34840442
Panic reaction 22.34 10.47 26 115830 1449 34839626
Tubulointerstitial nephritis 22.33 10.47 22 115834 21002 34820073
Ejaculation delayed 22.16 10.47 13 115843 269 34840806
Newborn persistent pulmonary hypertension 22.10 10.47 10 115846 117 34840958
Hepatic enzyme increased 21.87 10.47 62 115794 39018 34802057
Polyneuropathy 21.86 10.47 11 115845 14885 34826190
Transplant rejection 21.60 10.47 4 115852 10307 34830768
Energy increased 21.53 10.47 24 115832 1276 34839799
Mood altered 21.51 10.47 72 115784 8880 34832195
Acute respiratory distress syndrome 21.45 10.47 33 115823 25936 34815139
Prader-Willi syndrome 21.40 10.47 6 115850 13 34841062
Drug resistance 21.36 10.47 33 115823 25894 34815181
Pain in extremity 21.35 10.47 293 115563 126220 34714855
Aspergillus infection 21.31 10.47 7 115849 12247 34828828
Obsessive-compulsive symptom 21.31 10.47 10 115846 128 34840947
Rapid eye movements sleep abnormal 21.20 10.47 11 115845 177 34840898
Pruritus 21.13 10.47 337 115519 141644 34699431
Respiratory failure 21.11 10.47 244 115612 108328 34732747
Alcohol interaction 21.04 10.47 36 115820 2877 34838198
Enuresis 20.98 10.47 32 115824 2321 34838754
Drug intolerance 20.85 10.47 114 115742 59456 34781619
Unmasking of previously unidentified disease 20.78 10.47 20 115836 894 34840181
Hyperprolactinaemia 20.69 10.47 26 115830 1570 34839505
Gout 20.61 10.47 20 115836 19233 34821842
Haemorrhagic hepatic cyst 20.54 10.47 6 115850 16 34841059
Nephropathy toxic 20.51 10.47 8 115848 12580 34828495
Urinary retention 20.51 10.47 197 115659 36091 34804984
Chronic kidney disease 20.49 10.47 69 115787 41141 34799934
Product complaint 20.47 10.47 54 115802 5836 34835239
Therapeutic response unexpected 20.44 10.47 75 115781 9682 34831393
Medication error 20.42 10.47 150 115706 25415 34815660
Cellulitis 20.42 10.47 98 115758 52853 34788222
Attention deficit hyperactivity disorder 20.32 10.47 33 115823 2526 34838549
Oesophageal ulcer haemorrhage 20.26 10.47 11 115845 195 34840880
Prescription drug used without a prescription 20.21 10.47 30 115826 2124 34838951
Parasomnia 20.20 10.47 14 115842 390 34840685
COVID-19 pneumonia 20.13 10.47 16 115840 16951 34824124
Implant site extravasation 20.11 10.47 14 115842 393 34840682
Congenital megaureter 20.02 10.47 10 115846 148 34840927
Cerebral haemorrhage neonatal 20.01 10.47 12 115844 259 34840816
Haemoptysis 19.98 10.47 55 115801 34951 34806124
Cryptorchism 19.98 10.47 29 115827 2012 34839063
Haemophagocytic lymphohistiocytosis 19.93 10.47 9 115847 12964 34828111
Cerebral infarction 19.82 10.47 38 115818 27417 34813658
Sexual activity increased 19.55 10.47 6 115850 20 34841055
Tongue injury 19.54 10.47 9 115847 110 34840965
Schizophreniform disorder 19.52 10.47 8 115848 72 34841003
Liver disorder 19.47 10.47 51 115805 32946 34808129
Urinary hesitation 19.41 10.47 34 115822 2768 34838307
Muscle tightness 19.29 10.47 47 115809 4837 34836238
Rash maculo-papular 19.16 10.47 41 115815 28410 34812665
C-reactive protein abnormal 19.08 10.47 3 115853 8707 34832368
Hypocalcaemia 18.99 10.47 32 115824 24257 34816818
Infection 18.98 10.47 201 115655 90714 34750361
Colitis 18.91 10.47 63 115793 37687 34803388
Psychotic symptom 18.89 10.47 26 115830 1717 34839358
Euphoric mood 18.88 10.47 51 115805 5590 34835485
Violence-related symptom 18.78 10.47 15 115841 521 34840554
Crying 18.63 10.47 52 115804 5810 34835265
Tongue biting 18.62 10.47 19 115837 912 34840163
Influenza 18.53 10.47 93 115763 49573 34791502
Weight increased 18.51 10.47 421 115435 92612 34748463
High-pitched crying 18.45 10.47 5 115851 9 34841066
Somnambulism 18.40 10.47 35 115821 3037 34838038
Obesity 18.37 10.47 88 115768 12790 34828285
Periodic limb movement disorder 18.34 10.47 9 115847 128 34840947
Abdominal distension 18.31 10.47 116 115740 58376 34782699
Blood pressure fluctuation 18.18 10.47 35 115821 25214 34815861
Acute myocardial infarction 18.15 10.47 104 115752 53615 34787460
Congenital pulmonary valve atresia 18.13 10.47 7 115849 53 34841022
Congenital supraventricular tachycardia 18.10 10.47 5 115851 10 34841065
Painful erection 18.07 10.47 11 115845 244 34840831
Alcohol poisoning 18.01 10.47 38 115818 3555 34837520
Strabismus congenital 17.96 10.47 6 115850 28 34841047
Loose associations 17.90 10.47 7 115849 55 34841020
Apallic syndrome 17.88 10.47 11 115845 249 34840826
Nervousness 17.88 10.47 86 115770 12520 34828555
Cognitive disorder 17.84 10.47 159 115697 28534 34812541
Hypomagnesaemia 17.82 10.47 28 115828 21823 34819252
Cytopenia 17.78 10.47 10 115846 12713 34828362
Onychomycosis 17.78 10.47 30 115826 2370 34838705
Transaminases increased 17.78 10.47 39 115817 26784 34814291
Foetal growth restriction 17.76 10.47 41 115815 4076 34836999
Drug eruption 17.70 10.47 24 115832 19874 34821201
Disturbance in sexual arousal 17.68 10.47 9 115847 139 34840936
Hyperacusis 17.68 10.47 18 115838 862 34840213
Confabulation 17.68 10.47 9 115847 139 34840936
Action tremor 17.58 10.47 7 115849 58 34841017
Lymphomatoid papulosis 17.53 10.47 10 115846 196 34840879
Psoriatic arthropathy 17.49 10.47 24 115832 19774 34821301
Blood ethanol increased 17.46 10.47 14 115842 489 34840586
Coloboma 17.39 10.47 9 115847 144 34840931
Libido disorder 17.38 10.47 11 115845 262 34840813
Ejaculation disorder 17.35 10.47 19 115837 990 34840085
Palmar-plantar erythrodysaesthesia syndrome 17.35 10.47 18 115838 16777 34824298
Acute myeloid leukaemia 17.32 10.47 21 115835 18249 34822826
Abulia 17.30 10.47 15 115841 585 34840490
Social anxiety disorder 17.20 10.47 12 115844 338 34840737
Blood bilirubin increased 17.13 10.47 67 115789 38229 34802846
Hypersomnia 17.13 10.47 84 115772 12323 34828752
Gastrointestinal haemorrhage 17.13 10.47 199 115657 88278 34752797
Hyperuricaemia 17.11 10.47 3 115853 8040 34833035
Physical assault 17.04 10.47 20 115836 1125 34839950
Sedation complication 17.03 10.47 25 115831 1752 34839323
Alveolar bone resorption 16.94 10.47 5 115851 14 34841061
Septum pellucidum agenesis 16.80 10.47 7 115849 66 34841009
Gastrooesophageal reflux disease 16.79 10.47 196 115660 37728 34803347
Cardiac failure acute 16.76 10.47 7 115849 10563 34830512
Neonatal disorder 16.71 10.47 17 115839 813 34840262
Fungal infection 16.55 10.47 17 115839 15918 34825157
Pharyngeal dystonia 16.44 10.47 7 115849 70 34841005
Libido increased 16.36 10.47 17 115839 834 34840241
Arthropathy 16.33 10.47 41 115815 26866 34814209
Blood triglycerides increased 16.20 10.47 91 115765 14068 34827007
Dyspnoea exertional 16.17 10.47 81 115775 43198 34797877
Temperature regulation disorder 16.07 10.47 16 115840 746 34840329
Proteinuria 16.06 10.47 23 115833 18619 34822456
Respiratory dyskinesia 15.99 10.47 5 115851 18 34841057
Suspected suicide 15.97 10.47 43 115813 4705 34836370
Granulocytopenia 15.94 10.47 53 115803 6514 34834561
Localised infection 15.86 10.47 21 115835 17566 34823509
Tongue spasm 15.82 10.47 6 115850 43 34841032
Hypersexuality 15.77 10.47 22 115834 1471 34839604
Hypoglycaemia neonatal 15.76 10.47 25 115831 1876 34839199
Compulsive sexual behaviour 15.70 10.47 10 115846 241 34840834
Grunting 15.68 10.47 12 115844 391 34840684
Abnormal dreams 15.66 10.47 58 115798 7520 34833555
Transient tachypnoea of the newborn 15.66 10.47 9 115847 179 34840896
Pneumonia bacterial 15.65 10.47 10 115846 11862 34829213
Metabolic acidosis 15.61 10.47 83 115773 43597 34797478
Kidney transplant rejection 15.51 10.47 3 115853 7494 34833581
Haematotoxicity 15.50 10.47 4 115852 8190 34832885
Pulmonary embolism 15.44 10.47 207 115649 89539 34751536
Malpositioned teeth 15.39 10.47 5 115851 21 34841054
Thrombotic microangiopathy 15.37 10.47 8 115848 10622 34830453
Cytomegalovirus viraemia 15.31 10.47 3 115853 7427 34833648
Salivary hypersecretion 15.30 10.47 63 115793 8581 34832494
Reflux laryngitis 15.25 10.47 6 115850 48 34841027
Cataract congenital 15.24 10.47 7 115849 85 34840990
Obsessive rumination 15.21 10.47 4 115852 6 34841069
Psychiatric symptom 15.17 10.47 35 115821 3478 34837597
Delirium 15.12 10.47 217 115639 43774 34797301
Paraneoplastic rash 15.10 10.47 7 115849 87 34840988
Gangrene neonatal 15.10 10.47 9 115847 192 34840883
Hypoalbuminaemia 15.06 10.47 11 115845 12163 34828912
Dissociative identity disorder 15.03 10.47 5 115851 23 34841052
Enterocolitis 15.02 10.47 4 115852 8022 34833053
Oesophageal carcinoma 15.02 10.47 6 115850 9298 34831777
Hepatitis 14.84 10.47 36 115820 23868 34817207
Muscle contractions involuntary 14.83 10.47 24 115832 1832 34839243
Abdominal pain 14.77 10.47 421 115435 163197 34677878
Activation syndrome 14.75 10.47 7 115849 92 34840983
Left ventricular false tendon 14.64 10.47 6 115850 54 34841021
Drug screen false positive 14.63 10.47 15 115841 724 34840351
Second primary malignancy 14.63 10.47 4 115852 7882 34833193
Memory impairment 14.61 10.47 213 115643 43105 34797970
Deep vein thrombosis 14.55 10.47 142 115714 65106 34775969
Pregnancy 14.51 10.47 10 115846 276 34840799
Pulmonary microemboli 14.48 10.47 4 115852 8 34841067
Congenital hearing disorder 14.36 10.47 7 115849 98 34840977
Congenital coronary artery malformation 14.18 10.47 6 115850 59 34841016
Enteric neuropathy 14.14 10.47 3 115853 0 34841075
Nasal cavity packing 14.14 10.47 3 115853 0 34841075
Arterial ligation 14.14 10.47 3 115853 0 34841075
Constricted affect 14.14 10.47 3 115853 0 34841075
Foetal damage 14.14 10.47 3 115853 0 34841075
Hallucinations, mixed 14.13 10.47 29 115827 2660 34838415
Urinary incontinence 14.09 10.47 109 115747 18765 34822310
Lung disorder 14.09 10.47 63 115793 34633 34806442
Transposition of the great vessels 14.08 10.47 12 115844 457 34840618
Posture abnormal 14.02 10.47 26 115830 2213 34838862
Genital anaesthesia 13.87 10.47 4 115852 10 34841065
Moaning 13.87 10.47 15 115841 771 34840304
Hippocampal sclerosis 13.81 10.47 7 115849 107 34840968
Foetal death 13.80 10.47 9 115847 226 34840849
Product dispensing error 13.80 10.47 49 115807 6225 34834850
Dysarthria 13.77 10.47 176 115680 34606 34806469
Intraventricular haemorrhage neonatal 13.70 10.47 10 115846 303 34840772
Blood urea increased 13.66 10.47 53 115803 30311 34810764
Cyanosis neonatal 13.64 10.47 10 115846 305 34840770
Dysgraphia 13.63 10.47 26 115830 2261 34838814
Cough 13.63 10.47 386 115470 149754 34691321
Anxiety disorder due to a general medical condition 13.60 10.47 4 115852 11 34841064
Feelings of worthlessness 13.53 10.47 10 115846 309 34840766
Illness anxiety disorder 13.49 10.47 8 115848 169 34840906
Rales 13.48 10.47 8 115848 9875 34831200
Rash pruritic 13.46 10.47 45 115811 26896 34814179
Impaired work ability 13.46 10.47 52 115804 6878 34834197
Hypotension 13.45 10.47 599 115257 221050 34620025
Intentional product misuse 13.37 10.47 219 115637 45392 34795683
Anuria 13.35 10.47 9 115847 10376 34830699
Sneezing 13.35 10.47 43 115813 5199 34835876
Skin indentation 13.35 10.47 4 115852 12 34841063
Duplicate therapy error 13.32 10.47 8 115848 173 34840902
Peritonitis 13.32 10.47 21 115835 16344 34824731
Inappropriate schedule of product administration 13.30 10.47 137 115719 62159 34778916
Cardiac failure congestive 13.28 10.47 195 115661 83075 34758000
Product communication issue 13.27 10.47 11 115845 403 34840672
Post-traumatic stress disorder 13.26 10.47 23 115833 1858 34839217
Illusion 13.24 10.47 15 115841 812 34840263
Maculopathy 13.21 10.47 16 115840 930 34840145
Device related infection 13.21 10.47 23 115833 17214 34823861
Selective mutism 13.20 10.47 6 115850 71 34841004
Rebound psychosis 13.16 10.47 8 115848 177 34840898
Pericardial effusion 13.16 10.47 40 115816 24622 34816453
Blood pressure systolic increased 13.14 10.47 36 115820 22916 34818159
Migraine 13.09 10.47 101 115755 17377 34823698
Herpes zoster 13.07 10.47 64 115792 34335 34806740
Alanine aminotransferase increased 12.97 10.47 189 115667 80626 34760449
Drug dispensed to wrong patient 12.93 10.47 12 115844 512 34840563
Fallot's tetralogy 12.93 10.47 8 115848 183 34840892
Drug dose titration not performed 12.91 10.47 10 115846 332 34840743
Bladder dilatation 12.89 10.47 20 115836 1472 34839603
Emotional disorder 12.88 10.47 45 115811 5671 34835404
Drug ineffective 12.86 10.47 1322 114534 455429 34385646
Optic ischaemic neuropathy 12.82 10.47 24 115832 2058 34839017
Vascular dementia 12.80 10.47 12 115844 519 34840556
Renal injury 12.73 10.47 11 115845 11184 34829891
Poverty of thought content 12.71 10.47 5 115851 40 34841035
Hypersensitivity 12.71 10.47 135 115721 60900 34780175
Osteonecrosis of jaw 12.71 10.47 25 115831 17864 34823211
Poor feeding infant 12.68 10.47 12 115844 525 34840550
Disseminated intravascular coagulation 12.66 10.47 34 115822 21782 34819293
Lethargy 12.63 10.47 199 115657 40923 34800152
Diastasis recti abdominis 12.60 10.47 5 115851 41 34841034
Lower respiratory tract infection 12.52 10.47 58 115798 31579 34809496
Gun shot wound 12.49 10.47 17 115839 1111 34839964
Pathogen resistance 12.48 10.47 8 115848 9474 34831601
Oxygen saturation decreased 12.47 10.47 116 115740 53702 34787373
Anaphylactic shock 12.46 10.47 21 115835 15920 34825155
Hypercalcaemia 12.44 10.47 20 115836 15448 34825627
Mixed dementia 12.43 10.47 9 115847 269 34840806
Self-injurious ideation 12.41 10.47 21 115835 1663 34839412
Anaphylactic reaction 12.32 10.47 60 115796 32241 34808834
Haemolytic anaemia 12.28 10.47 10 115846 10469 34830606
Daydreaming 12.25 10.47 12 115844 548 34840527
Diffuse vasculitis 12.18 10.47 6 115850 86 34840989
Epstein-Barr virus infection 12.18 10.47 5 115851 7623 34833452
Hepatorenal failure 12.15 10.47 12 115844 554 34840521
Hepatic failure 12.13 10.47 66 115790 34465 34806610
Bankruptcy 12.09 10.47 4 115852 18 34841057
Wrong patient received product 12.08 10.47 27 115829 2627 34838448
Immune reconstitution inflammatory syndrome 12.08 10.47 7 115849 8752 34832323
Abdominoplasty 12.07 10.47 3 115853 3 34841072
Congenital gastric anomaly 12.07 10.47 3 115853 3 34841072
Colostomy infection 12.07 10.47 3 115853 3 34841072
Genital blister 12.07 10.47 3 115853 3 34841072
Eczema 12.06 10.47 27 115829 18409 34822666
Red blood cell elliptocytes present 12.05 10.47 7 115849 142 34840933
Headache 12.03 10.47 795 115061 199840 34641235
Personality disorder 12.03 10.47 17 115839 1151 34839924
Umbilical cord abnormality 12.01 10.47 5 115851 47 34841028
Drug tolerance increased 11.94 10.47 11 115845 465 34840610
Brugada syndrome 11.93 10.47 14 115842 787 34840288
Flashback 11.93 10.47 7 115849 145 34840930
Platelet aggregation decreased 11.92 10.47 4 115852 19 34841056
Velopharyngeal incompetence 11.92 10.47 4 115852 19 34841056
Cholangitis 11.90 10.47 7 115849 8682 34832393
Aphasia 11.89 10.47 116 115740 21338 34819737
Decreased interest 11.87 10.47 25 115831 2335 34838740
Hepatocellular injury 11.87 10.47 36 115820 22175 34818900
Plasma cell myeloma 11.84 10.47 86 115770 41951 34799124
Stoma site infection 11.81 10.47 14 115842 796 34840279
Ejection fraction decreased 11.77 10.47 29 115827 19125 34821950
Schizoaffective disorder 11.77 10.47 18 115838 1309 34839766
Self-medication 11.75 10.47 27 115829 2676 34838399
Skin turgor decreased 11.65 10.47 11 115845 480 34840595
Feeling drunk 11.63 10.47 22 115834 1901 34839174
Dyskinesia neonatal 11.61 10.47 3 115853 4 34841071
Body mass index increased 11.60 10.47 16 115840 1059 34840016
Emotional poverty 11.59 10.47 12 115844 586 34840489
Neoplasm progression 11.59 10.47 39 115817 23261 34817814
Dehydration 11.57 10.47 335 115521 129634 34711441
Spasmodic dysphonia 11.57 10.47 8 115848 222 34840853
Pyromania 11.57 10.47 5 115851 52 34841023
Hyperbilirubinaemia 11.57 10.47 24 115832 16819 34824256
Respiratory arrest 11.57 10.47 143 115713 27900 34813175
Food interaction 11.53 10.47 15 115841 938 34840137
Vitamin B complex deficiency 11.49 10.47 10 115846 392 34840683
Adrenal insufficiency 11.45 10.47 18 115838 14029 34827046
Electrocardiogram QT interval abnormal 11.43 10.47 6 115850 99 34840976
Aspartate aminotransferase increased 11.42 10.47 157 115699 67626 34773449
Neonatal seizure 11.40 10.47 11 115845 493 34840582
Poverty of speech 11.38 10.47 8 115848 228 34840847
Heat stroke 11.38 10.47 15 115841 950 34840125
Blood cholesterol increased 11.35 10.47 111 115745 20432 34820643
Morbid thoughts 11.32 10.47 8 115848 230 34840845
Premature baby 11.30 10.47 107 115749 19526 34821549
Sleep inertia 11.29 10.47 4 115852 23 34841052
Pseudocholinesterase deficiency 11.29 10.47 4 115852 23 34841052
Butterfly rash 11.27 10.47 6 115850 102 34840973
Sexually inappropriate behaviour 11.26 10.47 11 115845 501 34840574
Muscle contracture 11.21 10.47 17 115839 1227 34839848
Lymphoma 11.21 10.47 15 115841 12492 34828583
Delusional disorder, unspecified type 11.21 10.47 13 115843 722 34840353
Loss of employment 11.20 10.47 11 115845 504 34840571
Mallory-Weiss syndrome 11.20 10.47 18 115838 1366 34839709
Dementia 11.17 10.47 81 115775 13667 34827408
Fear 11.12 10.47 66 115790 10410 34830665
Dermatitis atopic 11.12 10.47 41 115815 5306 34835769
Panic disorder 11.10 10.47 17 115839 1237 34839838
Pancreatic carcinoma 11.06 10.47 8 115848 8893 34832182
Decreased appetite 11.06 10.47 445 115411 165947 34675128
Blood folate decreased 11.06 10.47 12 115844 619 34840456
Movement disorder 11.03 10.47 74 115782 12174 34828901
Juvenile myoclonic epilepsy 11.01 10.47 5 115851 59 34841016
Congenital skin dimples 10.98 10.47 7 115849 169 34840906
Pseudomonas infection 10.94 10.47 15 115841 12367 34828708
Tension 10.90 10.47 23 115833 2152 34838923
PCO2 abnormal 10.86 10.47 3 115853 6 34841069
Postmortem blood drug level increased 10.86 10.47 8 115848 246 34840829
Cleft palate 10.84 10.47 12 115844 633 34840442
General symptom 10.83 10.47 14 115842 870 34840205
Hyperphagia 10.83 10.47 18 115838 1405 34839670
Shock haemorrhagic 10.82 10.47 13 115843 11341 34829734
Skin necrosis 10.80 10.47 3 115853 5850 34835225
Autoscopy 10.77 10.47 8 115848 249 34840826
Weight 10.75 10.47 4 115852 27 34841048
Hyperreflexia 10.74 10.47 29 115827 3177 34837898
Yawning 10.73 10.47 11 115845 531 34840544
Strabismus 10.71 10.47 20 115836 1711 34839364
Mutism 10.69 10.47 14 115842 881 34840194
Neutrophil count increased 10.65 10.47 95 115761 17051 34824024
Contraindicated product administered 10.65 10.47 36 115820 21445 34819630
Eye movement disorder 10.64 10.47 34 115822 4093 34836982
Progressive multifocal leukoencephalopathy 10.62 10.47 10 115846 9754 34831321
Adjustment disorder with mixed anxiety and depressed mood 10.55 10.47 3 115853 7 34841068
Orthostatic tremor 10.55 10.47 3 115853 7 34841068
Chills 10.55 10.47 197 115659 80846 34760229
Bronchospasm 10.53 10.47 12 115844 10719 34830356
Epistaxis 10.51 10.47 133 115723 58118 34782957
Aplastic anaemia 10.51 10.47 10 115846 9706 34831369
Meconium in amniotic fluid 10.51 10.47 4 115852 29 34841046
Neurotoxicity 10.50 10.47 28 115828 17982 34823093
Tachycardia 10.48 10.47 361 115495 84411 34756664

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 1509.98 9.63 1271 285993 43756 79413368
Intentional self-injury 1481.00 9.63 1098 286166 31321 79425803
Suicidal ideation 1332.51 9.63 1506 285758 74834 79382290
Intentional overdose 1222.61 9.63 1699 285565 104261 79352863
Suicide attempt 1136.91 9.63 1447 285817 81485 79375639
Drug interaction 934.26 9.63 3448 283816 411735 79045389
Drug abuse 899.14 9.63 1879 285385 160812 79296312
Depression 762.28 9.63 2101 285163 214689 79242435
Anxiety 670.90 9.63 2194 285070 246318 79210806
Completed suicide 669.99 9.63 2177 285087 243590 79213534
Agitation 533.38 9.63 1137 286127 98578 79358546
Tremor 477.03 9.63 1522 285742 168561 79288563
Toxicity to various agents 433.44 9.63 2798 284466 418742 79038382
Sopor 406.99 9.63 547 286717 32463 79424661
Paranoia 363.89 9.63 398 286866 19034 79438090
Withdrawal syndrome 362.05 9.63 465 286799 26389 79430735
Akathisia 348.03 9.63 326 286938 12933 79444191
Pemphigus 336.96 9.63 4 287260 99578 79357546
Synovitis 334.11 9.63 68 287196 150666 79306458
Aggression 332.03 9.63 631 286633 50327 79406797
Hand deformity 328.35 9.63 10 287254 103909 79353215
Somnolence 319.52 9.63 1701 285563 237280 79219844
Overdose 316.52 9.63 1409 285855 182797 79274327
Psychotic disorder 304.21 9.63 540 286724 40862 79416262
Pyrexia 270.22 9.63 1393 285871 677316 78779808
Mania 263.30 9.63 327 286937 17933 79439191
Confusional state 261.37 9.63 2000 285264 315997 79141127
Joint swelling 250.80 9.63 408 286856 288238 79168886
Hyponatraemia 245.89 9.63 1278 285986 176570 79280554
Irritability 243.14 9.63 489 286775 40655 79416469
Hallucination, auditory 241.58 9.63 334 286930 20359 79436765
Abnormal behaviour 240.97 9.63 454 286810 35967 79421157
Febrile neutropenia 235.90 9.63 291 286973 230708 79226416
Drug intolerance 235.43 9.63 367 286897 263752 79193372
Dyskinesia 235.18 9.63 507 286757 44266 79412858
Contraindicated product administered 234.69 9.63 138 287126 157400 79299724
Infusion related reaction 230.98 9.63 294 286970 229943 79227181
Systemic lupus erythematosus 229.56 9.63 75 287189 121074 79336050
Pericarditis 228.94 9.63 48 287216 104188 79352936
Bruxism 226.74 9.63 155 287109 3871 79453253
Restlessness 226.71 9.63 511 286753 45981 79411143
Glossodynia 214.18 9.63 54 287210 103283 79353841
Hallucination 208.78 9.63 732 286532 85013 79372111
Extrapyramidal disorder 205.56 9.63 325 286939 22354 79434770
Drug withdrawal syndrome 203.20 9.63 411 286853 34307 79422817
Rheumatoid arthritis 201.11 9.63 274 286990 208196 79248928
Off label use 201.05 9.63 2196 285068 905019 78552105
Panic attack 199.07 9.63 332 286932 23884 79433240
Hypomania 197.05 9.63 185 287079 7359 79449765
Arthropathy 196.08 9.63 209 287055 176902 79280222
Treatment failure 187.82 9.63 202 287062 170284 79286840
Arthralgia 187.63 9.63 1248 286016 570555 78886569
Insomnia 184.81 9.63 1512 285752 243658 79213466
Stomatitis 177.67 9.63 160 287104 146597 79310527
Anger 175.36 9.63 260 287004 16902 79440222
Parkinsonism 174.88 9.63 255 287009 16329 79440795
Hallucination, visual 173.46 9.63 372 286892 32357 79424767
Dystonia 172.73 9.63 291 286973 21108 79436016
Depressed mood 169.11 9.63 469 286795 48011 79409113
Mydriasis 168.50 9.63 259 287005 17384 79439740
Tic 165.89 9.63 114 287150 2872 79454252
Rash 165.72 9.63 1312 285952 577046 78880078
Alopecia 163.34 9.63 370 286894 230985 79226139
Electrocardiogram QT prolonged 162.40 9.63 701 286563 89685 79367439
Nasopharyngitis 160.47 9.63 430 286834 253451 79203673
Homicidal ideation 159.82 9.63 118 287146 3339 79453785
Duodenal ulcer perforation 159.48 9.63 24 287240 66187 79390937
Helicobacter infection 157.44 9.63 30 287234 69674 79387450
Disturbance in attention 157.41 9.63 471 286793 50330 79406794
Mood swings 157.36 9.63 268 286996 19612 79437512
Delusion 155.99 9.63 271 286993 20152 79436972
Psychomotor hyperactivity 153.46 9.63 242 287022 16607 79440517
Wound 152.55 9.63 117 287147 116062 79341062
Folliculitis 148.36 9.63 14 287250 55366 79401758
Malignant neoplasm progression 147.70 9.63 163 287101 135827 79321297
Obsessive-compulsive disorder 146.54 9.63 141 287123 5786 79451338
Loss of libido 145.62 9.63 101 287163 2584 79454540
Disorientation 142.63 9.63 524 286740 62252 79394872
Poisoning deliberate 141.42 9.63 248 287016 18580 79438544
Therapeutic product effect decreased 139.07 9.63 235 287029 163628 79293496
Sleep disorder due to general medical condition, insomnia type 138.27 9.63 4 287260 43552 79413572
Loss of consciousness 138.14 9.63 1057 286207 166886 79290238
Self-injurious ideation 137.14 9.63 110 287154 3528 79453596
Bradyphrenia 136.78 9.63 180 287084 10460 79446664
Muscle rigidity 136.70 9.63 252 287012 19630 79437494
Seizure 136.04 9.63 1153 286111 187681 79269443
Feeling abnormal 136.02 9.63 1011 286253 158188 79298936
Renal impairment 135.08 9.63 225 287039 157558 79299566
Acute kidney injury 133.97 9.63 1211 286053 518193 78938931
Neuroleptic malignant syndrome 133.33 9.63 302 286962 27257 79429867
Psychomotor skills impaired 132.15 9.63 126 287138 5111 79452013
Bradykinesia 130.60 9.63 153 287111 7890 79449234
Hyperhidrosis 129.96 9.63 963 286301 150529 79306595
Peripheral swelling 129.25 9.63 516 286748 269101 79188023
C-reactive protein abnormal 127.54 9.63 13 287251 48354 79408770
Drug ineffective 126.79 9.63 2949 284315 1077964 78379160
Apathy 126.03 9.63 192 287072 12785 79444339
Depression suicidal 125.70 9.63 107 287157 3735 79453389
Hepatic enzyme increased 125.67 9.63 296 286968 182314 79274810
Thinking abnormal 125.39 9.63 193 287071 12968 79444156
General physical health deterioration 124.94 9.63 538 286726 274700 79182424
Hyperprolactinaemia 124.69 9.63 116 287148 4560 79452564
Nightmare 123.56 9.63 282 286982 25579 79431545
Swelling 123.07 9.63 386 286878 216325 79240799
Inappropriate antidiuretic hormone secretion 122.49 9.63 284 286980 26029 79431095
Colitis microscopic 121.50 9.63 171 287093 10597 79446527
Anorgasmia 120.91 9.63 68 287196 1186 79455938
Thrombocytopenia 120.09 9.63 519 286745 264740 79192384
Psychomotor retardation 119.86 9.63 129 287135 6055 79451069
Depressive symptom 119.28 9.63 131 287133 6292 79450832
Muscle injury 118.35 9.63 17 287247 48544 79408580
Neutropenia 117.21 9.63 585 286679 287125 79169999
Treatment noncompliance 115.98 9.63 433 286831 51835 79405289
Blood prolactin increased 115.74 9.63 104 287160 3907 79453217
Homicide 113.51 9.63 64 287200 1122 79456002
Sexual dysfunction 113.48 9.63 140 287124 7623 79449501
Blister 113.19 9.63 159 287105 119317 79337807
Priapism 112.94 9.63 108 287156 4397 79452727
Social avoidant behaviour 112.42 9.63 111 287153 4703 79452421
Pancytopenia 112.19 9.63 271 286993 165474 79291650
Suicidal behaviour 109.46 9.63 92 287172 3155 79453969
Intrusive thoughts 109.21 9.63 48 287216 476 79456648
Myoclonus 109 9.63 280 286984 27380 79429744
Disease progression 108.51 9.63 323 286941 184039 79273085
Impaired healing 107.95 9.63 94 287170 87561 79369563
Major depression 107.91 9.63 147 287117 8833 79448291
Psychiatric decompensation 107.01 9.63 99 287165 3864 79453260
Sinusitis 106.97 9.63 354 286910 195147 79261977
Infection 106.93 9.63 477 286787 241235 79215889
Amenorrhoea 106.50 9.63 135 287129 7557 79449567
Tachyphrenia 105.27 9.63 75 287189 2005 79455119
Tearfulness 104.89 9.63 119 287145 5926 79451198
Anaemia 104.70 9.63 1061 286203 443954 79013170
Lower respiratory tract infection 104.48 9.63 191 287073 129029 79328095
Emotional distress 102.29 9.63 347 286917 39622 79417502
Hyperreflexia 101.88 9.63 138 287126 8247 79448877
Psoriatic arthropathy 101.81 9.63 79 287185 77920 79379204
Sedation 99.81 9.63 411 286853 51484 79405640
Mental disorder 98.65 9.63 292 286972 31010 79426114
Oromandibular dystonia 98.31 9.63 56 287208 1002 79456122
Dizziness 98.16 9.63 2536 284728 523905 78933219
Libido decreased 97.90 9.63 108 287156 5213 79451911
Erectile dysfunction 97.23 9.63 183 287081 14481 79442643
Cytomegalovirus infection 97.06 9.63 18 287246 42626 79414498
Crying 95.74 9.63 238 287026 22805 79434319
Trismus 95.51 9.63 108 287156 5359 79451765
Neuropathy peripheral 94.86 9.63 232 287032 141073 79316051
Galactorrhoea 94.44 9.63 89 287175 3557 79453567
Catatonia 94.30 9.63 136 287128 8620 79448504
Fall 93.81 9.63 2359 284905 485270 78971854
Hypersensitivity 93.68 9.63 557 286707 261682 79195442
Schizophrenia 92.99 9.63 185 287079 15255 79441869
Septic shock 92.76 9.63 189 287075 122612 79334512
Pneumonia 92.48 9.63 1749 285515 658497 78798627
C-reactive protein increased 91.29 9.63 206 287058 128821 79328303
Sepsis 90.68 9.63 583 286681 268845 79188279
Rheumatic fever 89.17 9.63 3 287261 28522 79428602
Cardiac failure 87.04 9.63 277 286987 154565 79302559
Discomfort 86.89 9.63 203 287061 125414 79331710
Hallucinations, mixed 86.04 9.63 115 287149 6784 79450340
Generalised tonic-clonic seizure 83.06 9.63 346 286918 43564 79413560
Product substitution issue 81.84 9.63 207 287057 20049 79437075
Myelosuppression 79.81 9.63 23 287241 40273 79416851
Restless legs syndrome 79.80 9.63 204 287060 19888 79437236
Anhedonia 79.70 9.63 170 287094 14728 79442396
Product use issue 78.50 9.63 439 286825 209383 79247741
Speech disorder 78.45 9.63 396 286868 54049 79403075
Maculopathy 77.11 9.63 71 287193 2754 79454370
Delirium 76.58 9.63 545 286719 84082 79373042
Rheumatoid factor positive 76.34 9.63 62 287202 59777 79397347
Respiratory arrest 76.29 9.63 409 286855 57141 79399983
Emotional disorder 74.48 9.63 162 287102 14225 79442899
Tardive dyskinesia 73.95 9.63 135 287129 10436 79446688
Irritable bowel syndrome 72.77 9.63 70 287194 62171 79394953
Poisoning 72.39 9.63 228 287036 25044 79432080
Mucosal inflammation 72.16 9.63 100 287164 75480 79381644
Negative thoughts 72.08 9.63 51 287213 1348 79455776
Euphoric mood 71.79 9.63 112 287152 7614 79449510
Drug dependence 71.52 9.63 314 286950 40455 79416669
Muscle twitching 71.47 9.63 224 287040 24540 79432584
Abnormal dreams 70.25 9.63 138 287126 11274 79445850
Intentional product misuse 70.02 9.63 584 286680 94581 79362543
Dysarthria 69.85 9.63 450 286814 67172 79389952
Intentional product use issue 69.78 9.63 296 286968 151816 79305308
Abdominal discomfort 69.64 9.63 573 286691 250154 79206970
Obsessive thoughts 69.54 9.63 46 287218 1086 79456038
Musculoskeletal pain 68.73 9.63 168 287096 102186 79354938
Yawning 68.54 9.63 49 287215 1317 79455807
Platelet count decreased 68.16 9.63 416 286848 194248 79262876
Infarction 67.57 9.63 83 287181 4499 79452625
Alcoholism 67.52 9.63 75 287189 3648 79453476
Mental impairment 67.20 9.63 185 287079 18851 79438273
Affective disorder 66.96 9.63 113 287151 8206 79448918
Gestational diabetes 66.69 9.63 97 287167 6196 79450928
Coma 66.42 9.63 603 286661 100046 79357078
Vertigo 66.09 9.63 451 286813 68631 79388493
Amnesia 65.98 9.63 421 286843 62636 79394488
Salivary hypersecretion 65.63 9.63 153 287111 14071 79443053
Activation syndrome 65.59 9.63 28 287236 257 79456867
Pleural effusion 65.21 9.63 285 286979 144977 79312147
Psychotic symptom 64.49 9.63 63 287201 2634 79454490
Foaming at mouth 64.46 9.63 54 287210 1843 79455281
Impulsive behaviour 64.28 9.63 65 287199 2835 79454289
Inflammation 63.64 9.63 153 287111 93600 79363524
Flat affect 63.03 9.63 55 287209 1986 79455138
Gastrointestinal disorder 62.29 9.63 228 287036 121977 79335147
Hip arthroplasty 61.22 9.63 26 287238 35730 79421394
Ill-defined disorder 61.06 9.63 89 287175 65786 79391338
Complication of device insertion 60.32 9.63 93 287171 6257 79450867
Knee arthroplasty 60.08 9.63 41 287223 43207 79413917
Lung disorder 59.96 9.63 125 287139 80432 79376692
Reversible cerebral vasoconstriction syndrome 59.65 9.63 64 287200 2993 79454131
Hepatic function abnormal 59.13 9.63 108 287156 72999 79384125
Prostate cancer 58.89 9.63 23 287241 33245 79423879
Mood altered 58.65 9.63 169 287095 17678 79439446
Blood creatine phosphokinase increased 58.27 9.63 423 286841 65667 79391457
Torticollis 57.53 9.63 56 287208 2331 79454793
Ascites 57.30 9.63 116 287148 75446 79381678
Genital hypoaesthesia 57.27 9.63 23 287241 178 79456946
Pain 57.03 9.63 2019 285245 701783 78755341
Bone marrow failure 56.86 9.63 60 287204 51047 79406077
Persistent genital arousal disorder 56.18 9.63 25 287239 256 79456868
Antipsychotic drug level increased 54.85 9.63 86 287178 5871 79451253
Haemophagocytic lymphohistiocytosis 54.74 9.63 7 287257 21830 79435294
Abulia 54.45 9.63 38 287226 982 79456142
Arthritis 54.27 9.63 221 287043 114659 79342465
Derealisation 54.10 9.63 46 287218 1603 79455521
Pneumocystis jirovecii pneumonia 53.51 9.63 25 287239 32483 79424641
Bipolar disorder 53.38 9.63 98 287166 7609 79449515
Neutrophil count decreased 52.84 9.63 168 287096 93791 79363333
Bone erosion 52.10 9.63 3 287261 17844 79439280
Tension 51.27 9.63 71 287193 4333 79452791
Depersonalisation/derealisation disorder 51.22 9.63 47 287217 1815 79455309
Drug hypersensitivity 50.71 9.63 1423 285841 297493 79159631
Alcohol poisoning 50.64 9.63 74 287190 4747 79452377
White blood cell count decreased 50.15 9.63 435 286829 187853 79269271
Tachycardia 49.57 9.63 908 286356 176860 79280264
Pain in extremity 49.56 9.63 970 286294 363568 79093556
Hypersomnia 49.34 9.63 189 287075 22897 79434227
Dyspnoea 48.51 9.63 2559 284705 854466 78602658
Cardiac arrest 48.32 9.63 880 286384 171216 79285908
Flashback 48.12 9.63 23 287241 281 79456843
Bipolar I disorder 47.70 9.63 48 287216 2081 79455043
Bronchopulmonary aspergillosis 47.45 9.63 11 287253 22283 79434841
Clonus 47.40 9.63 87 287177 6753 79450371
Sensation of foreign body 47.12 9.63 77 287187 5445 79451679
Dissociation 47.07 9.63 65 287199 3956 79453168
Balance disorder 47.00 9.63 554 286710 98303 79358821
Disturbance in sexual arousal 45.96 9.63 21 287243 230 79456894
Burning mouth syndrome 45.37 9.63 27 287237 526 79456598
Fear 45.36 9.63 178 287086 21808 79435316
Confabulation 45.31 9.63 26 287238 472 79456652
Thrombotic microangiopathy 44.87 9.63 9 287255 20160 79436964
Dysphoria 44.50 9.63 69 287195 4665 79452459
Drug reaction with eosinophilia and systemic symptoms 44.27 9.63 104 287160 64140 79392984
Interstitial lung disease 44.06 9.63 232 287032 112368 79344756
Syncope 44.05 9.63 899 286365 178550 79278574
Memory impairment 43.72 9.63 604 286660 111130 79345994
Eye movement disorder 43.53 9.63 92 287172 7919 79449205
Pruritus 42.83 9.63 1088 286176 393560 79063564
Blood creatinine increased 42.73 9.63 355 286909 154702 79302422
Cytokine release syndrome 42.64 9.63 40 287224 35958 79421166
Overweight 42.58 9.63 63 287201 4087 79453037
Somnambulism 42.50 9.63 75 287189 5646 79451478
Tumour lysis syndrome 41.64 9.63 17 287247 23922 79433202
Product complaint 41.56 9.63 124 287140 13225 79443899
Muscle tightness 41.19 9.63 121 287143 12793 79444331
Herpes zoster 40.93 9.63 184 287080 92899 79364225
Violence-related symptom 40.83 9.63 28 287236 703 79456421
Cholecystitis chronic 40.82 9.63 102 287162 9804 79447320
Lethargy 40.63 9.63 460 286804 80832 79376292
Fibromyalgia 40.57 9.63 109 287155 64231 79392893
Transplant rejection 40.56 9.63 10 287254 19427 79437697
Persistent depressive disorder 40.33 9.63 34 287230 1171 79455953
Osteoporosis 40.24 9.63 84 287180 54028 79403096
Tubulointerstitial nephritis 40.22 9.63 47 287217 38188 79418936
Hyponatraemic seizure 40.15 9.63 25 287239 530 79456594
Formication 40.12 9.63 68 287196 4955 79452169
Pregnancy with implant contraceptive 40.04 9.63 41 287223 1815 79455309
Swollen tongue 39.58 9.63 276 286988 42294 79414830
Drug screen positive 39.37 9.63 75 287189 5988 79451136
Cogwheel rigidity 39.32 9.63 52 287212 3036 79454088
Device expulsion 39.31 9.63 191 287073 25670 79431454
Poverty of thought content 39.26 9.63 13 287251 53 79457071
Blood pressure fluctuation 39.21 9.63 118 287146 67027 79390097
Cycloplegia 39.09 9.63 9 287255 3 79457121
Dysphemia 38.82 9.63 55 287209 3429 79453695
Orgasm abnormal 38.73 9.63 17 287247 168 79456956
Uterine perforation 38.53 9.63 76 287188 6227 79450897
Adrenal insufficiency 38.26 9.63 28 287236 28459 79428665
Mobility decreased 38.24 9.63 270 286994 121905 79335219
Emotional poverty 38.16 9.63 29 287235 858 79456266
Heavy menstrual bleeding 37.94 9.63 124 287140 13887 79443237
Victim of chemical submission 37.69 9.63 24 287240 530 79456594
Psychiatric symptom 37.31 9.63 80 287184 6955 79450169
Urinary incontinence 37.31 9.63 264 287000 40645 79416479
Persecutory delusion 37.30 9.63 65 287199 4844 79452280
Disorganised speech 37.28 9.63 42 287222 2075 79455049
Posture abnormal 37.26 9.63 57 287207 3809 79453315
Drowning 37.18 9.63 28 287236 817 79456307
Upper gastrointestinal haemorrhage 37.13 9.63 266 286998 41114 79416010
Haematotoxicity 36.52 9.63 6 287258 15513 79441611
Metabolic syndrome 36.22 9.63 47 287217 2693 79454431
Renal failure 36.08 9.63 508 286756 200460 79256664
Chorea 35.99 9.63 44 287220 2373 79454751
Drug dose titration not performed 35.99 9.63 27 287237 783 79456341
Semen discolouration 35.97 9.63 9 287255 8 79457116
Rabbit syndrome 35.86 9.63 20 287244 343 79456781
Ejaculation failure 35.76 9.63 20 287244 345 79456779
Urinary retention 35.69 9.63 336 286928 56294 79400830
Disseminated intravascular coagulation 35.65 9.63 46 287218 35796 79421328
Palmar-plantar erythrodysaesthesia syndrome 35.64 9.63 40 287224 33094 79424030
Death 35.37 9.63 1674 285590 564840 78892284
Leukopenia 35.25 9.63 260 287004 116253 79340871
Self esteem decreased 35.04 9.63 29 287235 973 79456151
Mutism 35.03 9.63 43 287221 2329 79454795
Liver disorder 35.02 9.63 138 287126 72279 79384845
Phospholipidosis 34.78 9.63 17 287247 219 79456905
Pseudodementia 34.75 9.63 10 287254 22 79457102
Nephropathy toxic 34.71 9.63 15 287249 20404 79436720
Unresponsive to stimuli 34.66 9.63 330 286934 55458 79401666
COVID-19 34.52 9.63 382 286882 157292 79299832
Abnormal weight gain 34.40 9.63 45 287219 2599 79454525
Premature ejaculation 34.27 9.63 12 287252 60 79457064
Device dislocation 34.03 9.63 184 287080 25786 79431338
Autoimmune disorder 33.80 9.63 9 287255 16603 79440521
Bursitis 33.63 9.63 48 287216 35796 79421328
Ideas of reference 33.59 9.63 15 287249 155 79456969
Rhabdomyolysis 33.52 9.63 540 286724 102591 79354533
Somatic symptom disorder of pregnancy 33.48 9.63 13 287251 91 79457033
Multiple organ dysfunction syndrome 33.26 9.63 275 286989 119971 79337153
Headache 33.26 9.63 2760 284504 651012 78806112
Proteinuria 33.07 9.63 41 287223 32461 79424663
Anaphylactic shock 33.00 9.63 49 287215 35947 79421177
Injection site pain 32.79 9.63 304 286960 129534 79327590
Drug resistance 32.69 9.63 64 287200 42149 79414975
Stiff person syndrome 32.52 9.63 18 287246 304 79456820
Cytomegalovirus viraemia 32.40 9.63 4 287260 12817 79444307
Attention deficit hyperactivity disorder 32.19 9.63 49 287215 3260 79453864
Sleep-related eating disorder 32.17 9.63 24 287240 690 79456434
Myelodysplastic syndrome 32.14 9.63 37 287227 30264 79426860
Food interaction 32.10 9.63 35 287229 1667 79455457
Embedded device 32.08 9.63 49 287215 3270 79453854
Mental status changes 31.72 9.63 375 286889 66584 79390540
Rash maculo-papular 31.71 9.63 100 287164 55978 79401146
Grandiosity 31.64 9.63 22 287242 565 79456559
Hyperkalaemia 31.47 9.63 262 287002 114136 79342988
Schizoaffective disorder bipolar type 31.43 9.63 16 287248 226 79456898
Platelet aggregation abnormal 31.38 9.63 10 287254 35 79457089
Grip strength decreased 31.37 9.63 20 287244 21849 79435275
Cataract 30.92 9.63 117 287147 62003 79395121
Cerebral vasoconstriction 30.86 9.63 32 287232 1438 79455686
Pneumonitis 30.71 9.63 114 287150 60746 79396378
Retroplacental haematoma 30.68 9.63 13 287251 117 79457007
Device placement issue 30.38 9.63 29 287235 1178 79455946
Palpitations 30.30 9.63 632 286632 125978 79331146
Wrong patient 30.28 9.63 18 287246 350 79456774
Negativism 30.23 9.63 25 287239 838 79456286
Substance abuse 30.18 9.63 95 287169 10431 79446693
Nervousness 30.10 9.63 215 287049 33200 79423924
Dystonic tremor 29.97 9.63 15 287249 204 79456920
Energy increased 29.69 9.63 47 287217 3235 79453889
Aspergillus infection 29.64 9.63 16 287248 19145 79437979
Logorrhoea 29.59 9.63 55 287209 4310 79452814
Action tremor 29.47 9.63 19 287245 429 79456695
Therapy non-responder 29.37 9.63 203 287061 92102 79365022
Blepharospasm 29.28 9.63 65 287199 5786 79451338
Cough 29.19 9.63 1054 286210 365735 79091389
Pancreatic fibrosis 29.12 9.63 12 287252 100 79457024
Suspected suicide 29.00 9.63 94 287170 10482 79446642
Urticaria 28.85 9.63 481 286783 184720 79272404
Urine sodium decreased 28.81 9.63 16 287248 272 79456852
Cardio-respiratory arrest 28.76 9.63 550 286714 107960 79349164
Acute psychosis 28.76 9.63 53 287211 4127 79452997
Lymphadenopathy 28.69 9.63 97 287167 53150 79403974
Heat stroke 28.66 9.63 33 287231 1670 79455454
Drug screen false positive 28.59 9.63 27 287237 1082 79456042
Dementia with Lewy bodies 28.58 9.63 24 287240 822 79456302
Physical assault 28.44 9.63 32 287232 1579 79455545
Acute myeloid leukaemia 28.35 9.63 42 287222 30843 79426281
Chronic kidney disease 28.35 9.63 132 287132 66022 79391102
Blood pressure diastolic abnormal 28.32 9.63 17 287247 19185 79437939
Erythema 28.27 9.63 601 286663 222689 79234435
Oedema 28.08 9.63 285 286979 119295 79337829
Head discomfort 27.99 9.63 115 287149 14387 79442737
Neoplasm progression 27.95 9.63 94 287170 51588 79405536
Conversion disorder 27.91 9.63 34 287230 1827 79455297
Central vision loss 27.67 9.63 8 287256 18 79457106
Aplastic anaemia 27.63 9.63 15 287249 17890 79439234
Pseudomonas infection 27.49 9.63 21 287243 20882 79436242
Male orgasmic disorder 27.48 9.63 10 287254 57 79457067
Facet joint syndrome 27.44 9.63 4 287260 11298 79445826
Postmortem blood drug level increased 27.43 9.63 23 287241 786 79456338
Cytopenia 27.42 9.63 20 287244 20363 79436761
Delusion of replacement 27.41 9.63 13 287251 156 79456968
Hypertonia 27.25 9.63 72 287192 7160 79449964
Nystagmus 27.13 9.63 88 287176 9816 79447308
Suppressed lactation 26.92 9.63 16 287248 311 79456813
Urinary hesitation 26.76 9.63 52 287212 4214 79452910
Respiratory tract infection 26.71 9.63 88 287176 48601 79408523
Hyperphagia 26.55 9.63 39 287225 2513 79454611
Libido disorder 26.50 9.63 15 287249 265 79456859
Miosis 26.48 9.63 120 287144 15669 79441455
Muscle contracture 26.44 9.63 37 287227 2280 79454844
Heart rate decreased 26.33 9.63 147 287117 70169 79386955
Pressure of speech 26.26 9.63 27 287237 1201 79455923
Ejaculation delayed 26.22 9.63 13 287251 173 79456951
Male sexual dysfunction 26.13 9.63 14 287250 221 79456903
Acute graft versus host disease 26.12 9.63 3 287261 10164 79446960
Atrial fibrillation 26.12 9.63 529 286735 197357 79259767
Brain injury 26.03 9.63 96 287168 11421 79445703
Autoscopy 26.00 9.63 10 287254 68 79457056
Prescription drug used without a prescription 25.87 9.63 50 287214 4035 79453089
Hallucination, olfactory 25.63 9.63 18 287246 470 79456654
Graft versus host disease 25.60 9.63 11 287253 15015 79442109
Negative symptoms in schizophrenia 25.59 9.63 12 287252 140 79456984
Decreased interest 25.59 9.63 47 287217 3650 79453474
Pleurothotonus 25.53 9.63 38 287226 2478 79454646
Colitis 25.46 9.63 157 287107 73150 79383974
Tongue spasm 25.39 9.63 11 287253 105 79457019
Product tampering 25.35 9.63 17 287247 411 79456713
Depressed level of consciousness 25.30 9.63 489 286775 96163 79360961
Pathogen resistance 25.25 9.63 10 287254 14332 79442792
Musculoskeletal stiffness 25.19 9.63 461 286803 174547 79282577
Cellulitis 25.16 9.63 261 287003 108799 79348325
Creatinine renal clearance decreased 25.10 9.63 19 287245 18983 79438141
Polyneuropathy 25.06 9.63 30 287234 24121 79433003
Phobia 25.06 9.63 17 287247 419 79456705
Eosinophilic pneumonia acute 25.05 9.63 25 287239 1073 79456051
Behaviour disorder 24.97 9.63 64 287200 6249 79450875
Generalised anxiety disorder 24.95 9.63 35 287229 2162 79454962
Osteoarthritis 24.91 9.63 198 287066 87111 79370013
Injection site erythema 24.86 9.63 172 287092 78025 79379099
Drug level increased 24.86 9.63 235 287029 39416 79417708
Liver injury 24.83 9.63 112 287152 56502 79400622
Resting tremor 24.80 9.63 29 287235 1492 79455632
Febrile bone marrow aplasia 24.76 9.63 8 287256 13012 79444112
Intermenstrual bleeding 24.68 9.63 61 287203 5823 79451301
Middle insomnia 24.65 9.63 119 287145 15950 79441174
Hyperacusis 24.63 9.63 35 287229 2188 79454936
Inappropriate affect 24.57 9.63 29 287235 1507 79455617
Factor XIII deficiency 24.51 9.63 10 287254 81 79457043
Antidepressant drug level increased 24.51 9.63 17 287247 435 79456689
Osteonecrosis of jaw 24.50 9.63 77 287187 43149 79413975
Hereditary angioedema 24.19 9.63 57 287207 5278 79451846
Head injury 24.19 9.63 223 287041 37146 79419978
Post-traumatic stress disorder 24.18 9.63 54 287210 4827 79452297
Dermatillomania 24.16 9.63 13 287251 207 79456917
Enuresis 24.06 9.63 42 287222 3134 79453990
Hyponatraemic syndrome 24.05 9.63 21 287243 759 79456365
Multiple sclerosis relapse 24.01 9.63 265 286999 46268 79410856
Blood calcium decreased 23.99 9.63 49 287215 31770 79425354
Rales 23.96 9.63 22 287242 19979 79437145
Diffuse large B-cell lymphoma 23.94 9.63 7 287257 12142 79444982
Therapeutic response unexpected 23.93 9.63 138 287126 19808 79437316
Somatic symptom disorder 23.88 9.63 37 287227 2500 79454624
Cognitive disorder 23.80 9.63 369 286895 69557 79387567
Muscle contractions involuntary 23.75 9.63 46 287218 3719 79453405
Radiologically isolated syndrome 23.64 9.63 6 287258 6 79457118
Aphasia 23.60 9.63 265 286999 46467 79410657
Morbid thoughts 23.55 9.63 21 287243 781 79456343
Cardiogenic shock 23.52 9.63 75 287189 41839 79415285
Localised infection 23.43 9.63 64 287200 37511 79419613
Antisocial behaviour 23.42 9.63 20 287244 701 79456423
Vision blurred 23.22 9.63 522 286742 105376 79351748
Adulterated product 23.20 9.63 14 287250 280 79456844
Blood pressure systolic abnormal 23.10 9.63 17 287247 17230 79439894
Haemoglobin decreased 23.09 9.63 616 286648 221503 79235621
Therapeutic product effect incomplete 23.01 9.63 365 286899 141280 79315844
COVID-19 pneumonia 22.98 9.63 43 287221 28806 79428318
Hallucination, gustatory 22.94 9.63 9 287255 65 79457059
Hyperuricaemia 22.88 9.63 7 287257 11792 79445332
Oral candidiasis 22.87 9.63 45 287219 29583 79427541
Cystitis haemorrhagic 22.85 9.63 3 287261 9169 79447955
Joint range of motion decreased 22.83 9.63 54 287210 33228 79423896
Borderline personality disorder 22.82 9.63 22 287242 905 79456219
Dyspnoea exertional 22.80 9.63 202 287062 86871 79370253
Incoherent 22.58 9.63 70 287194 7622 79449502
Oesophageal carcinoma 22.56 9.63 6 287258 11078 79446046
Postural orthostatic tachycardia syndrome 22.56 9.63 22 287242 918 79456206
Panic reaction 22.43 9.63 51 287213 4614 79452510
Immunosuppressant drug level increased 22.37 9.63 3 287261 9024 79448100
Drug eruption 22.36 9.63 82 287182 43853 79413271
Idiopathic intracranial hypertension 22.35 9.63 41 287223 3181 79453943
Granulocytopenia 22.34 9.63 91 287173 11340 79445784
Psychogenic seizure 22.28 9.63 31 287233 1900 79455224
Lip dry 22.25 9.63 14 287250 15404 79441720
Peripheral venous disease 22.21 9.63 15 287249 15894 79441230
Peritonitis 22.15 9.63 42 287222 27994 79429130
Amniotic fluid volume increased 22.15 9.63 11 287253 147 79456977
Delusional disorder, unspecified type 22.02 9.63 20 287244 762 79456362
Merycism 21.95 9.63 13 287251 251 79456873
Panic disorder 21.94 9.63 39 287225 2953 79454171
Sciatica 21.92 9.63 55 287209 33167 79423957
Alanine aminotransferase abnormal 21.85 9.63 3 287261 8864 79448260
Hypocalcaemia 21.75 9.63 99 287165 49825 79407299
Environmental exposure 21.52 9.63 15 287249 387 79456737
Injection site pruritus 21.46 9.63 79 287185 42204 79414920
Rapid eye movements sleep abnormal 21.28 9.63 13 287251 266 79456858
Tenosynovitis 21.27 9.63 15 287249 15539 79441585
Perinatal depression 21.25 9.63 15 287249 395 79456729
Plasma cell myeloma 21.24 9.63 109 287155 53150 79403974
Injection site bruising 21.21 9.63 76 287188 40926 79416198
Enterocolitis 21.19 9.63 13 287251 14499 79442625
Unintended pregnancy 21.18 9.63 45 287219 3888 79453236
Communication disorder 21.11 9.63 46 287218 4044 79453080
Medication error 21.04 9.63 356 286908 68286 79388838
Collagen-vascular disease 20.95 9.63 9 287255 84 79457040
Feeling drunk 20.94 9.63 50 287214 4669 79452455
Prader-Willi syndrome 20.91 9.63 6 287258 13 79457111
Respiratory failure 20.88 9.63 494 286770 180417 79276707
Distractibility 20.87 9.63 19 287245 726 79456398
Mitochondrial encephalomyopathy 20.86 9.63 7 287257 30 79457094
Second primary malignancy 20.75 9.63 13 287251 14337 79442787
Wound infection 20.71 9.63 34 287230 23957 79433167
Personality change 20.71 9.63 82 287182 10088 79447036
Ankylosing spondylitis 20.69 9.63 9 287255 12196 79444928
Acute respiratory distress syndrome 20.66 9.63 85 287179 43982 79413142
Sleep disorder 20.60 9.63 428 286836 85249 79371875
Foreign body in reproductive tract 20.56 9.63 18 287246 653 79456471
Gaze palsy 20.54 9.63 38 287226 2967 79454157
Loose associations 20.48 9.63 8 287256 57 79457067
Adenovirus infection 20.48 9.63 3 287261 8444 79448680
Metastases to lymph nodes 20.47 9.63 6 287258 10391 79446733
Movement disorder 20.42 9.63 168 287096 27091 79430033
Electrocardiogram T wave abnormal 20.39 9.63 43 287221 3695 79453429
Cold sweat 20.27 9.63 126 287138 18573 79438551
Photophobia 20.21 9.63 135 287129 20393 79436731
Apallic syndrome 20.19 9.63 21 287243 947 79456177
Maternal exposure during pregnancy 20.17 9.63 358 286906 136180 79320944
Long QT syndrome 20.16 9.63 57 287207 5898 79451226
Diverticulitis 20.07 9.63 91 287173 45845 79411279
Parkinsonism hyperpyrexia syndrome 20.07 9.63 12 287252 236 79456888
Obsessive-compulsive symptom 19.91 9.63 11 287253 185 79456939
Excessive masturbation 19.90 9.63 9 287255 96 79457028
Judgement impaired 19.90 9.63 24 287240 1276 79455848
Alanine aminotransferase increased 19.86 9.63 440 286824 162130 79294994
Vanishing bile duct syndrome 19.71 9.63 28 287236 1750 79455374
Chronic obstructive pulmonary disease 19.66 9.63 424 286840 84995 79372129
Coordination abnormal 19.62 9.63 118 287146 17194 79439930
Dermatitis atopic 19.61 9.63 80 287184 9976 79447148
Transient psychosis 19.58 9.63 8 287256 65 79457059
Total lung capacity increased 19.55 9.63 32 287232 2266 79454858
Basal cell carcinoma 19.52 9.63 69 287195 37306 79419818
Impaired reasoning 19.50 9.63 9 287255 101 79457023
Illness anxiety disorder 19.50 9.63 12 287252 249 79456875
Bladder cancer 19.48 9.63 25 287239 19501 79437623
BK virus infection 19.43 9.63 4 287260 8800 79448324
Eosinophilic myocarditis 19.43 9.63 23 287241 1199 79455925
Morose 19.37 9.63 7 287257 39 79457085
Vomiting 19.33 9.63 2708 284556 663120 78794004
Skin ulcer 19.31 9.63 115 287149 54035 79403089
Dissociative disorder 19.30 9.63 19 287245 802 79456322
Complication of device removal 19.23 9.63 43 287221 3846 79453278
Disinhibition 19.22 9.63 34 287230 2564 79454560
Morning sickness 19.18 9.63 16 287248 543 79456581
Gallbladder cholesterolosis 19.13 9.63 17 287247 629 79456495
Parasomnia 19.13 9.63 16 287248 545 79456579
Tuberculosis 19.07 9.63 16 287248 15182 79441942
Blood pressure systolic increased 19.07 9.63 152 287112 66834 79390290
Hyponatraemic encephalopathy 18.93 9.63 13 287251 327 79456797
Social anxiety disorder 18.88 9.63 16 287248 555 79456569
Asphyxia 18.86 9.63 88 287176 11632 79445492
Catastrophic reaction 18.83 9.63 6 287258 21 79457103
Parkinsonian gait 18.77 9.63 20 287244 928 79456196
Drop attacks 18.70 9.63 21 287243 1034 79456090
Lid lag 18.69 9.63 8 287256 74 79457050
Macrophages increased 18.69 9.63 12 287252 269 79456855
Ejection fraction decreased 18.62 9.63 63 287201 34514 79422610
Sexual activity increased 18.62 9.63 6 287258 22 79457102
Bleeding time prolonged 18.56 9.63 23 287241 1258 79455866
Hypokinesia 18.56 9.63 125 287139 18935 79438189
Intracranial meningioma malignant 18.52 9.63 4 287260 0 79457124
Influenza 18.46 9.63 342 286922 129264 79327860
Affect lability 18.45 9.63 85 287179 11174 79445950
Aplasia 18.45 9.63 3 287261 7817 79449307
Biliary dyskinesia 18.44 9.63 33 287231 2512 79454612
Adjustment disorder with depressed mood 18.34 9.63 5 287259 9081 79448043
Impulse-control disorder 18.30 9.63 27 287237 1747 79455377
Tinnitus 18.30 9.63 242 287022 44091 79413033
Pulmonary toxicity 18.26 9.63 12 287252 12902 79444222
Diaphragmatic rupture 18.23 9.63 11 287253 220 79456904
Dopamine dysregulation syndrome 18.16 9.63 15 287249 502 79456622
Cardiac failure acute 18.11 9.63 25 287239 18904 79438220
Ataxia 18.06 9.63 153 287111 24886 79432238
Cardiac murmur 18.02 9.63 108 287156 15716 79441408
Periodic limb movement disorder 18.01 9.63 10 287254 170 79456954
Paraesthesia 17.98 9.63 792 286472 175531 79281593
Body mass index increased 17.93 9.63 28 287236 1905 79455219
Drug abuser 17.91 9.63 55 287209 5958 79451166
Skin toxicity 17.90 9.63 4 287260 8310 79448814
Polymenorrhoea 17.85 9.63 20 287244 982 79456142
Pulmonary haemorrhage 17.85 9.63 16 287248 14701 79442423
Oedema peripheral 17.85 9.63 735 286529 251553 79205571
Drug dispensed to wrong patient 17.84 9.63 17 287247 689 79456435
Loss of personal independence in daily activities 17.82 9.63 490 286774 102090 79355034
Drug-device interaction 17.80 9.63 8 287256 84 79457040
Polyarthritis 17.72 9.63 11 287253 12191 79444933
Conjunctival abrasion 17.69 9.63 5 287259 10 79457114
Feeling jittery 17.52 9.63 92 287172 12749 79444375
Fungal infection 17.47 9.63 84 287180 41664 79415460
Female orgasmic disorder 17.47 9.63 6 287258 28 79457096
Sexually inappropriate behaviour 17.47 9.63 15 287249 530 79456594
Tongue biting 17.32 9.63 29 287235 2092 79455032
Presyncope 17.32 9.63 225 287039 40829 79416295
Feelings of worthlessness 17.30 9.63 15 287249 537 79456587
Exposure during pregnancy 17.27 9.63 482 286782 100650 79356474
Torsade de pointes 17.24 9.63 124 287140 19188 79437936
Caesarean section 17.23 9.63 90 287174 12445 79444679
Claustrophobia 17.13 9.63 22 287242 1248 79455876
Reflexes abnormal 17.11 9.63 19 287245 924 79456200
Epstein-Barr virus infection 17.10 9.63 16 287248 14400 79442724
Pneumonia bacterial 17.06 9.63 27 287237 19304 79437820
Pre-eclampsia 17.03 9.63 60 287204 6981 79450143
Diplopia 17.00 9.63 190 287074 33276 79423848
Oral discomfort 16.98 9.63 75 287189 9685 79447439
Neutropenic sepsis 16.95 9.63 46 287218 27018 79430106
Target skin lesion 16.86 9.63 9 287255 141 79456983
Product communication issue 16.80 9.63 20 287244 1049 79456075
Rhinovirus infection 16.78 9.63 4 287260 7949 79449175
Hypoalbuminaemia 16.74 9.63 32 287232 21265 79435859
Kidney transplant rejection 16.68 9.63 8 287256 10238 79446886
Feeling guilty 16.63 9.63 18 287246 850 79456274
Suicide threat 16.62 9.63 7 287257 62 79457062
Haemolytic anaemia 16.58 9.63 24 287240 17796 79439328
Erythromelalgia 16.57 9.63 10 287254 200 79456924
Dislocation of vertebra 16.55 9.63 4 287260 7876 79449248
Boredom 16.52 9.63 6 287258 34 79457090
Hypersexuality 16.52 9.63 25 287239 1655 79455469
Urine chloride decreased 16.51 9.63 8 287256 101 79457023
Metastases to bone 16.46 9.63 40 287224 24387 79432737
Diarrhoea 16.45 9.63 2856 284408 877633 78579491
Haemoptysis 16.44 9.63 126 287138 55873 79401251
Metastases to lung 16.38 9.63 25 287239 18138 79438986
Incontinence 16.34 9.63 97 287167 14067 79443057
Maternal exposure during breast feeding 16.33 9.63 33 287231 2752 79454372
Delusional disorder, persecutory type 16.32 9.63 14 287250 494 79456630
Gout 16.31 9.63 41 287223 24708 79432416
Glucose tolerance impaired in pregnancy 16.29 9.63 4 287260 3 79457121
Accommodation disorder 16.26 9.63 15 287249 583 79456541
Stress 16.08 9.63 388 286876 79224 79377900
Dysgraphia 16.07 9.63 41 287223 3991 79453133
Device adhesion issue 16.07 9.63 3 287261 7072 79450052
Bladder dilatation 16.03 9.63 28 287236 2091 79455033
Hepatic failure 16.02 9.63 142 287122 61070 79396054
Marital problem 15.98 9.63 10 287254 214 79456910
Dementia Alzheimer's type 15.91 9.63 19 287245 1000 79456124
Menstruation irregular 15.89 9.63 47 287217 4989 79452135
CYP3A4 polymorphism 15.88 9.63 7 287257 70 79457054
Hyperbilirubinaemia 15.86 9.63 41 287223 24477 79432647
Serum serotonin decreased 15.80 9.63 5 287259 17 79457107
Petit mal epilepsy 15.79 9.63 51 287213 5676 79451448
Screaming 15.69 9.63 40 287224 3893 79453231
Epilepsy 15.62 9.63 220 287044 40640 79416484
Menopausal disorder 15.58 9.63 6 287258 41 79457083
Daydreaming 15.57 9.63 18 287246 915 79456209
Selective mutism 15.54 9.63 7 287257 74 79457050
Jaundice cholestatic 15.50 9.63 81 287183 11203 79445921
Eczema 15.46 9.63 85 287179 40733 79416391
Abortion missed 15.41 9.63 21 287243 1262 79455862
Stereotypy 15.38 9.63 18 287246 927 79456197
Fear of weight gain 15.37 9.63 5 287259 19 79457105
Ophthalmic vein thrombosis 15.35 9.63 10 287254 230 79456894
Reduced facial expression 15.31 9.63 32 287232 2733 79454391
Cardiac failure congestive 15.30 9.63 393 286871 142009 79315115
Cardiotoxicity 15.21 9.63 13 287251 12226 79444898
Immunodeficiency 15.19 9.63 35 287229 21733 79435391
Embolic cerebellar infarction 15.17 9.63 5 287259 20 79457104
Neoplasm malignant 15.14 9.63 61 287203 31749 79425375
Alcohol interaction 14.91 9.63 45 287219 4829 79452295
Obsessive rumination 14.88 9.63 4 287260 6 79457118
Feeling of despair 14.87 9.63 32 287232 2789 79454335
Death of relative 14.83 9.63 10 287254 244 79456880
Hepatocellular carcinoma 14.75 9.63 7 287257 9014 79448110
Water intoxication 14.74 9.63 16 287248 758 79456366
Vascular dementia 14.74 9.63 17 287247 862 79456262
Drooling 14.73 9.63 51 287213 5883 79451241
Gallbladder injury 14.69 9.63 20 287244 1201 79455923
Pulmonary tuberculosis 14.66 9.63 5 287259 7860 79449264
Gastrointestinal motility disorder 14.66 9.63 52 287212 6070 79451054
Product odour abnormal 14.66 9.63 21 287243 1323 79455801
Postpartum haemorrhage 14.65 9.63 23 287241 1572 79455552
Joint hyperextension 14.63 9.63 11 287253 320 79456804
Soliloquy 14.63 9.63 15 287249 665 79456459
Mitochondrial cytopathy 14.62 9.63 12 287252 398 79456726
Vanishing twin syndrome 14.61 9.63 7 287257 86 79457038
Hepatic cancer 14.60 9.63 10 287254 10519 79446605
Dependence 14.56 9.63 29 287235 2393 79454731
Personality disorder 14.54 9.63 52 287212 6094 79451030
Paraneoplastic rash 14.54 9.63 7 287257 87 79457037
Dermatitis acneiform 14.52 9.63 9 287255 9984 79447140
Fatigue 14.51 9.63 3044 284220 926683 78530441
Blood test abnormal 14.46 9.63 26 287238 17684 79439440
Neurotoxicity 14.46 9.63 64 287200 32454 79424670
Immunisation reaction 14.45 9.63 13 287251 489 79456635
Pyromania 14.45 9.63 5 287259 24 79457100
Conjunctivitis 14.44 9.63 46 287218 25669 79431455
Multiple sclerosis 14.44 9.63 133 287131 22149 79434975
Partner stress 14.37 9.63 11 287253 329 79456795
Subchorionic haemorrhage 14.35 9.63 8 287256 137 79456987
Blood triglycerides increased 14.35 9.63 127 287137 20913 79436211
Gambling disorder 14.33 9.63 26 287238 2000 79455124
Abnormal loss of weight 14.30 9.63 64 287200 8312 79448812
Aspartate aminotransferase increased 14.27 9.63 385 286879 138256 79318868
Alcohol use 14.22 9.63 44 287220 4787 79452337
Coagulopathy 14.18 9.63 74 287190 35932 79421192
Oxygen saturation decreased 14.17 9.63 355 286909 128692 79328432
Anal incontinence 14.17 9.63 113 287151 18055 79439069
Asthma-chronic obstructive pulmonary disease overlap syndrome 14.16 9.63 34 287230 3187 79453937
Oral herpes 14.13 9.63 51 287213 27403 79429721
Blood phosphorus increased 14.12 9.63 10 287254 10337 79446787
Alcohol abuse 14.11 9.63 47 287217 5316 79451808
Agitated depression 14.09 9.63 12 287252 419 79456705
Weight increased 14.04 9.63 1171 286093 276215 79180909
Breast pain 14.00 9.63 63 287201 8202 79448922
Ear infection 14.00 9.63 70 287194 34362 79422762
Food craving 13.99 9.63 23 287241 1634 79455490
Respiratory tract congestion 13.99 9.63 32 287232 19922 79437202
Basophil count abnormal 13.97 9.63 5 287259 27 79457097
Somatic delusion 13.95 9.63 15 287249 703 79456421
Constipation 13.94 9.63 856 286408 282194 79174930
Olfactory nerve disorder 13.89 9.63 3 287261 0 79457124
Arterial ligation 13.89 9.63 3 287261 0 79457124
Anaplastic large cell lymphoma T- and null-cell types stage IV 13.89 9.63 3 287261 0 79457124
Long-chain acyl-coenzyme A dehydrogenase deficiency 13.89 9.63 3 287261 0 79457124
Postictal headache 13.89 9.63 3 287261 0 79457124
Overconfidence 13.89 9.63 3 287261 0 79457124
Differential white blood cell count abnormal 13.87 9.63 26 287238 2051 79455073
Optic ischaemic neuropathy 13.82 9.63 32 287232 2929 79454195
Retching 13.82 9.63 109 287155 17358 79439766
Increased appetite 13.80 9.63 82 287182 11896 79445228
Drug-induced liver injury 13.75 9.63 162 287102 65955 79391169
Maternal drugs affecting foetus 13.73 9.63 23 287241 1660 79455464
Renal injury 13.69 9.63 25 287239 16902 79440222
Levator syndrome 13.67 9.63 5 287259 29 79457095
Anorectal discomfort 13.66 9.63 36 287228 3575 79453549
Haemorrhagic hepatic cyst 13.61 9.63 6 287258 60 79457064
Oesophageal pain 13.56 9.63 40 287224 4239 79452885
Transfusion 13.55 9.63 36 287228 21294 79435830
Blood lactate dehydrogenase increased 13.54 9.63 84 287180 39086 79418038
Helplessness 13.50 9.63 11 287253 361 79456763
Inadequate analgesia 13.47 9.63 42 287222 4587 79452537
Gait deviation 13.44 9.63 6 287258 62 79457062
Sluggishness 13.39 9.63 53 287211 6519 79450605
Acute myocardial infarction 13.36 9.63 196 287068 76840 79380284
Schizophreniform disorder 13.35 9.63 8 287256 158 79456966
Breast enlargement 13.35 9.63 22 287242 1567 79455557
Libido increased 13.30 9.63 25 287239 1976 79455148
Maternal condition affecting foetus 13.26 9.63 8 287256 160 79456964
Tongue haematoma 13.23 9.63 9 287255 223 79456901
Schizoaffective disorder 13.22 9.63 26 287238 2126 79454998
Large intestine perforation 13.19 9.63 20 287244 14547 79442577
Swelling face 13.18 9.63 343 286921 70869 79386255
Glomerular filtration rate decreased 13.18 9.63 40 287224 22662 79434462
Nausea 13.18 9.63 3752 283512 953444 78503680
Lack of spontaneous speech 13.16 9.63 9 287255 225 79456899
Ectopic pregnancy 13.14 9.63 23 287241 1720 79455404
Adverse event 13.12 9.63 146 287118 60068 79397056
Cholangitis 13.12 9.63 16 287248 12760 79444364
Gastrointestinal perforation 13.12 9.63 3 287261 6134 79450990
Hypomagnesaemia 13.10 9.63 107 287157 46804 79410320
Painful erection 13.04 9.63 8 287256 165 79456959
Exposure via breast milk 13.03 9.63 17 287247 979 79456145
Intestinal perforation 13.00 9.63 27 287237 17399 79439725
Breast cancer stage I 12.95 9.63 4 287260 6696 79450428
Liver function test increased 12.88 9.63 87 287177 39686 79417438
Foetal exposure during pregnancy 12.87 9.63 48 287216 5742 79451382
Hypersensitivity pneumonitis 12.86 9.63 36 287228 3703 79453421
Temporomandibular joint syndrome 12.85 9.63 37 287227 3868 79453256
Hepatitis B 12.83 9.63 7 287257 8325 79448799
Herpes simplex 12.79 9.63 15 287249 12172 79444952
Genital anaesthesia 12.78 9.63 4 287260 13 79457111
Factor XIII Inhibition 12.76 9.63 5 287259 36 79457088
Multiple-drug resistance 12.71 9.63 8 287256 8800 79448324
Peripheral sensory neuropathy 12.68 9.63 17 287247 13016 79444108
Device related infection 12.67 9.63 72 287192 34222 79422902
Hypochloraemia 12.65 9.63 28 287236 2487 79454637
Foetal death 12.65 9.63 60 287204 7984 79449140
Alveolar bone resorption 12.65 9.63 6 287258 72 79457052
Bankruptcy 12.64 9.63 5 287259 37 79457087
Blood ethanol increased 12.64 9.63 14 287250 679 79456445
Compulsions 12.61 9.63 11 287253 397 79456727
Pelvic pain 12.58 9.63 87 287177 13294 79443830
Renal tubular necrosis 12.56 9.63 47 287217 24992 79432132
Anxiety disorder due to a general medical condition 12.55 9.63 4 287260 14 79457110
Hyporesponsive to stimuli 12.55 9.63 25 287239 2063 79455061
Cardiac failure chronic 12.47 9.63 13 287251 11122 79446002
Blood pressure increased 12.46 9.63 628 286636 210732 79246392
Pharyngeal swelling 12.45 9.63 58 287206 7661 79449463
Menopause 12.43 9.63 25 287239 2077 79455047
Malpositioned teeth 12.42 9.63 5 287259 39 79457085
Implant site irritation 12.40 9.63 7 287257 123 79457001
Joint stiffness 12.40 9.63 91 287173 40739 79416385
Slow response to stimuli 12.38 9.63 23 287241 1802 79455322
Trichotillomania 12.35 9.63 8 287256 182 79456942
Pulmonary microemboli 12.34 9.63 4 287260 15 79457109
Herbal interaction 12.32 9.63 12 287252 500 79456624
Weight 12.31 9.63 5 287259 40 79457084
Female sexual dysfunction 12.31 9.63 5 287259 40 79457084
Musculoskeletal disorder 12.30 9.63 38 287226 21410 79435714
Gastric hypomotility 12.28 9.63 8 287256 184 79456940
Product taste abnormal 12.25 9.63 26 287238 2245 79454879
Compulsive sexual behaviour 12.24 9.63 9 287255 253 79456871
Amniotic cavity infection 12.23 9.63 15 287249 812 79456312
Rash erythematous 12.22 9.63 141 287123 57628 79399496
Oesophageal ulcer haemorrhage 12.22 9.63 13 287251 602 79456522
Lipidosis 12.20 9.63 5 287259 41 79457083
Candida infection 12.17 9.63 84 287180 38130 79418994
Lactate pyruvate ratio increased 12.16 9.63 6 287258 79 79457045
Atrioventricular dissociation 12.07 9.63 10 287254 336 79456788
Premature labour 12.06 9.63 61 287203 8329 79448795
Abnormal uterine bleeding 12.05 9.63 17 287247 1056 79456068
Pneumatosis intestinalis 12.04 9.63 4 287260 6393 79450731
Change of bowel habit 12.01 9.63 29 287235 2728 79454396
Hepatic lesion 12.01 9.63 5 287259 6954 79450170
Joint injury 12.01 9.63 65 287199 31270 79425854
Vasodilation procedure 12.00 9.63 5 287259 43 79457081
Concomitant disease aggravated 11.99 9.63 18 287246 13149 79443975
Purple glove syndrome 11.94 9.63 9 287255 263 79456861
Skin reaction 11.90 9.63 25 287239 16043 79441081
Lymphomatoid papulosis 11.90 9.63 10 287254 343 79456781
Haematemesis 11.89 9.63 259 287005 52005 79405119
Hyperthermia 11.86 9.63 108 287156 17929 79439195
Drug tolerance increased 11.84 9.63 13 287251 624 79456500
Metastases to liver 11.83 9.63 57 287207 28257 79428867
Hippocampal atrophy 11.82 9.63 3 287261 3 79457121
Barbiturates positive 11.82 9.63 3 287261 3 79457121
Nasal cavity packing 11.82 9.63 3 287261 3 79457121
Ejaculation disorder 11.80 9.63 12 287252 527 79456597
Neutropenic colitis 11.79 9.63 3 287261 5704 79451420
Serositis 11.79 9.63 15 287249 843 79456281
Reflux laryngitis 11.76 9.63 8 287256 198 79456926
Orthostatic hypotension 11.73 9.63 275 286989 55889 79401235
Poor personal hygiene 11.71 9.63 12 287252 532 79456592
Mood disorder due to a general medical condition 11.70 9.63 5 287259 46 79457078
Metastases to central nervous system 11.69 9.63 26 287238 16349 79440775
Suspiciousness 11.68 9.63 13 287251 634 79456490
Body temperature decreased 11.60 9.63 68 287196 32077 79425047
Vaginal haemorrhage 11.60 9.63 125 287139 21692 79435432
Blood urea increased 11.56 9.63 116 287148 48674 79408450
Cholestasis of pregnancy 11.55 9.63 16 287248 977 79456147
Atrial septal defect 11.54 9.63 23 287241 1899 79455225
Back pain 11.52 9.63 941 286323 303239 79153885
Akinesia 11.50 9.63 32 287232 3280 79453844
Lymphoproliferative disorder 11.50 9.63 3 287261 5612 79451512
Snoring 11.43 9.63 45 287219 5521 79451603
Polymenorrhagia 11.43 9.63 5 287259 49 79457075
Oropharyngeal pain 11.42 9.63 303 286961 109050 79348074
Mixed dementia 11.40 9.63 9 287255 282 79456842
Bronchitis 11.40 9.63 371 286893 130273 79326851
Epistaxis 11.39 9.63 310 286954 111205 79345919
Dyspraxia 11.37 9.63 9 287255 283 79456841
Mallory-Weiss syndrome 11.37 9.63 29 287235 2823 79454301
Shoplifting 11.36 9.63 3 287261 4 79457120
Orgasmic sensation decreased 11.34 9.63 5 287259 50 79457074
Haematuria 11.30 9.63 177 287087 68659 79388465
Delusion of reference 11.30 9.63 7 287257 147 79456977
Blood pressure diastolic increased 11.30 9.63 22 287242 14520 79442604
Systemic candida 11.28 9.63 5 287259 6701 79450423
Pulmonary embolism 11.28 9.63 740 286524 170914 79286210
Pneumothorax 11.27 9.63 58 287206 28265 79428859
Delusional perception 11.26 9.63 10 287254 370 79456754
Platelet aggregation decreased 11.25 9.63 5 287259 51 79457073
Poor venous access 11.25 9.63 31 287233 18118 79439006
Injection site swelling 11.20 9.63 112 287152 47020 79410104
Tendonitis 11.15 9.63 46 287218 23784 79433340
Cytomegalovirus chorioretinitis 11.12 9.63 3 287261 5487 79451637
Osteomyelitis 11.09 9.63 71 287193 32794 79424330
Cerebral infarction 11.08 9.63 108 287156 45568 79411556
Hypercalcaemia 11.03 9.63 87 287177 38343 79418781
Hippocampal sclerosis 11.02 9.63 7 287257 154 79456970
Premature rupture of membranes 11.01 9.63 36 287228 4033 79453091
Eosinophilic pneumonia 10.96 9.63 43 287221 5267 79451857
Retroperitoneal fibrosis 10.95 9.63 13 287251 680 79456444
Parakeratosis 10.94 9.63 10 287254 384 79456740
Arrested labour 10.94 9.63 7 287257 156 79456968
Tongue discolouration 10.93 9.63 34 287230 3709 79453415
Gun shot wound 10.92 9.63 17 287247 1153 79455971
Coprolalia 10.92 9.63 5 287259 55 79457069
Respiratory dyskinesia 10.92 9.63 5 287259 55 79457069
Sinus bradycardia 10.91 9.63 139 287125 25108 79432016
Respiratory disorder 10.90 9.63 106 287158 44750 79412374
Disturbance in social behaviour 10.88 9.63 41 287223 4929 79452195
Neutrophilia 10.87 9.63 57 287207 7894 79449230
Renal cancer 10.86 9.63 17 287247 12209 79444915
Poverty of speech 10.83 9.63 12 287252 582 79456542
Sleep inertia 10.82 9.63 4 287260 24 79457100
Cataplexy 10.79 9.63 15 287249 919 79456205
Post concussion syndrome 10.76 9.63 12 287252 586 79456538
Exposure via ingestion 10.76 9.63 42 287222 5132 79451992
Implant site extravasation 10.75 9.63 14 287250 805 79456319
Lupus-like syndrome 10.74 9.63 21 287243 13836 79443288
Premature baby 10.73 9.63 34 287230 3746 79453378
Pulmonary mass 10.70 9.63 61 287203 28973 79428151
Deprescribing error 10.69 9.63 4 287260 25 79457099
Renal tubular disorder 10.66 9.63 5 287259 6481 79450643
Central nervous system lupus 10.65 9.63 11 287253 492 79456632
Blood citric acid increased 10.61 9.63 5 287259 59 79457065
Accidental overdose 10.61 9.63 201 287063 39380 79417744
Jaundice 10.60 9.63 132 287132 53217 79403907
Hypokalaemia 10.58 9.63 627 286637 143413 79313711
Device kink 10.57 9.63 22 287242 1873 79455251
Guillain-Barre syndrome 10.57 9.63 10 287254 8955 79448169
Bacteraemia 10.53 9.63 72 287192 32752 79424372
Fear of injection 10.50 9.63 7 287257 7467 79449657
Endophthalmitis 10.49 9.63 5 287259 6423 79450701
Serum ferritin increased 10.47 9.63 12 287252 9835 79447289
Hypersensitivity vasculitis 10.45 9.63 6 287258 6937 79450187
Product monitoring error 10.43 9.63 10 287254 8896 79448228
Klebsiella infection 10.39 9.63 26 287238 15694 79441430
Coma scale abnormal 10.38 9.63 60 287204 8618 79448506
Initial insomnia 10.37 9.63 51 287213 6887 79450237
Amnestic disorder 10.35 9.63 12 287252 612 79456512
Bacterial infection 10.34 9.63 68 287196 31212 79425912
Sleep talking 10.34 9.63 16 287248 1080 79456044
Generalised oedema 10.34 9.63 47 287217 23662 79433462
Breast discomfort 10.32 9.63 10 287254 414 79456710
Bone pain 10.31 9.63 140 287124 55602 79401522
Antidepressant drug level decreased 10.30 9.63 3 287261 7 79457117
Pancreatic enzymes decreased 10.30 9.63 3 287261 7 79457117
Acute generalised exanthematous pustulosis 10.30 9.63 30 287234 17224 79439900
Impaired self-care 10.25 9.63 27 287237 2680 79454444
Suspected suicide attempt 10.22 9.63 9 287255 329 79456795
Squamous cell carcinoma 10.20 9.63 26 287238 15596 79441528
Live birth 10.20 9.63 34 287230 18710 79438414
Gait disturbance 10.17 9.63 874 286390 206632 79250492
Self-medication 10.14 9.63 41 287223 5091 79452033
Granuloma 10.09 9.63 9 287255 8288 79448836
Catheterisation cardiac 10.07 9.63 4 287260 5724 79451400
Nervous system disorder 10.02 9.63 144 287120 26712 79430412
Pelvic inflammatory disease 10.02 9.63 18 287246 1374 79455750
Economic problem 10.02 9.63 24 287240 2246 79454878
Drug dose omission by device 9.99 9.63 5 287259 6245 79450879
Skin infection 9.99 9.63 33 287231 18212 79438912
Injury 9.97 9.63 357 286907 77139 79379985
Dementia 9.92 9.63 134 287130 24525 79432599
Chronic sinusitis 9.87 9.63 20 287244 13006 79444118
Muscle spasms 9.87 9.63 744 286520 173986 79283138
Subileus 9.86 9.63 4 287260 5650 79451474
Product storage error 9.85 9.63 28 287236 16198 79440926
Hypnagogic hallucination 9.83 9.63 7 287257 187 79456937
Leukaemoid reaction 9.82 9.63 9 287255 347 79456777
Pseudomonal sepsis 9.78 9.63 5 287259 6169 79450955
Cushingoid 9.77 9.63 12 287252 9540 79447584
Culture throat positive 9.76 9.63 3 287261 9 79457115
Hostility 9.74 9.63 24 287240 2286 79454838
Enteritis 9.73 9.63 24 287240 14559 79442565
Antiphospholipid antibodies 9.73 9.63 6 287258 125 79456999
Blood uric acid increased 9.71 9.63 21 287243 13339 79443785
Myasthenia gravis 9.68 9.63 14 287250 10385 79446739
Vitamin B complex deficiency 9.67 9.63 13 287251 771 79456353
Haematochezia 9.65 9.63 241 287023 87404 79369720
Seizure like phenomena 9.64 9.63 21 287243 1846 79455278

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Agitation neonatal 35.47 18.76 60 2171 588 86973
Premature baby 28.68 18.76 34 2197 3894 83667
Human herpesvirus 6 infection 21.16 18.76 15 2216 45 87516
Fever neonatal 18.97 18.76 9 2222 8 87553

Pharmacologic Action:

SourceCodeDescription
ATC N06AB06 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:50949 SSRI
FDA EPC N0000175696 Serotonin Reuptake Inhibitor
FDA MoA N0000182137 Cytochrome P450 2D6 Inhibitors
MeSH PA D000928 Antidepressive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D017367 Selective Serotonin Reuptake Inhibitors
MeSH PA D018490 Serotonin Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Premenstrual dysphoric disorder indication 596004
Social phobia indication 25501002 DOID:11257
Depressive disorder indication 35489007
Posttraumatic stress disorder indication 47505003 DOID:2055
Obsessive-compulsive disorder indication 191736004 DOID:10933
Panic disorder indication 371631005 DOID:594
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Seasonal affective disorder off-label use 247803002
Cholestatic pruritus off-label use 707150004
Suicidal thoughts contraindication 6471006
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Upper gastrointestinal hemorrhage contraindication 37372002
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Blood coagulation disorder contraindication 64779008 DOID:1247
Weight loss contraindication 89362005
Hyponatremia contraindication 89627008
Seizure disorder contraindication 128613002
Mania contraindication 231494001
Hypomania contraindication 231496004
Disease of liver contraindication 235856003 DOID:409
Serotonin syndrome contraindication 371089000




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.61 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 9.54 CHEMBL CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 7.24 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel Ki 5.17 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Kd 6.38 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR Ki 6.11 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 5.67 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.25 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR Ki 6.86 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 7.08 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 6.13 PDSP
Muscarinic acetylcholine receptor M2 GPCR Ki 5.68 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 5.89 PDSP
Muscarinic acetylcholine receptor M4 GPCR Ki 5.85 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 5.72 PDSP
Alpha-2C adrenergic receptor GPCR Ki 6.19 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Kd 7.60 WOMBAT-PK
Cytochrome P450 2C19 Enzyme IC50 6 DRUG MATRIX
Melanocortin receptor 5 GPCR Ki 5.37 DRUG MATRIX
Alpha-2A adrenergic receptor GPCR Ki 6.97 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 6.48 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 5.89 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 9.07 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 7.11 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 7.24 CHEMBL
Transporter Transporter Ki 6.80 CHEMBL
Transcriptional activator protein luxR Unclassified IC50 4.57 CHEMBL
Sigma intracellular receptor 2 Unclassified Ki 5.28 CHEMBL

External reference:

IDSource
4020551 VUID
N0000148257 NUI
D00825 KEGG_DRUG
79559-97-0 SECONDARY_CAS_RN
4020394 VANDF
4020551 VANDF
C0074393 UMLSCUI
CHEBI:9123 CHEBI
SRE PDB_CHEM_ID
CHEMBL809 ChEMBL_ID
DB01104 DRUGBANK_ID
CHEMBL1709 ChEMBL_ID
D020280 MESH_DESCRIPTOR_UI
68617 PUBCHEM_CID
4798 IUPHAR_LIGAND_ID
5277 INN_ID
QUC7NX6WMB UNII
155137 RXNORM
169461 MMSL
39959 MMSL
5457 MMSL
83167 MMSL
d00880 MMSL
003629 NDDF
004615 NDDF
321958004 SNOMEDCT_US
372594008 SNOMEDCT_US
96211006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Zoloft HUMAN PRESCRIPTION DRUG LABEL 1 0049-0050 SOLUTION, CONCENTRATE 20 mg ORAL NDA 35 sections
Zoloft HUMAN PRESCRIPTION DRUG LABEL 1 0049-0050 SOLUTION, CONCENTRATE 20 mg ORAL NDA 35 sections
Zoloft HUMAN PRESCRIPTION DRUG LABEL 1 0049-4900 TABLET, FILM COATED 50 mg ORAL NDA 35 sections
Zoloft HUMAN PRESCRIPTION DRUG LABEL 1 0049-4900 TABLET, FILM COATED 50 mg ORAL NDA 35 sections
Zoloft HUMAN PRESCRIPTION DRUG LABEL 1 0049-4910 TABLET, FILM COATED 100 mg ORAL NDA 35 sections
Zoloft HUMAN PRESCRIPTION DRUG LABEL 1 0049-4910 TABLET, FILM COATED 100 mg ORAL NDA 35 sections
Zoloft HUMAN PRESCRIPTION DRUG LABEL 1 0049-4960 TABLET, FILM COATED 25 mg ORAL NDA 35 sections
Zoloft HUMAN PRESCRIPTION DRUG LABEL 1 0049-4960 TABLET, FILM COATED 25 mg ORAL NDA 35 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9580 TABLET, FILM COATED 100 mg ORAL ANDA 31 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9581 TABLET, FILM COATED 50 mg ORAL ANDA 31 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9582 TABLET, FILM COATED 25 mg ORAL ANDA 31 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0143-9654 TABLET, FILM COATED 100 mg ORAL ANDA 31 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0143-9655 TABLET, FILM COATED 50 mg ORAL ANDA 31 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0143-9656 TABLET, FILM COATED 25 mg ORAL ANDA 31 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0615-7989 TABLET, FILM COATED 25 mg ORAL ANDA 24 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0615-7989 TABLET, FILM COATED 25 mg ORAL ANDA 24 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0615-7989 TABLET, FILM COATED 25 mg ORAL ANDA 24 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0615-7990 TABLET, FILM COATED 50 mg ORAL ANDA 24 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0615-7990 TABLET, FILM COATED 50 mg ORAL ANDA 24 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0615-7990 TABLET, FILM COATED 50 mg ORAL ANDA 24 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0615-7991 TABLET, FILM COATED 100 mg ORAL ANDA 24 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0615-7991 TABLET, FILM COATED 100 mg ORAL ANDA 24 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0615-7991 TABLET, FILM COATED 100 mg ORAL ANDA 24 sections
Sertraline hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8485 TABLET, FILM COATED 25 mg ORAL ANDA 30 sections
Sertraline hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8486 TABLET, FILM COATED 50 mg ORAL ANDA 30 sections
Sertraline hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8487 TABLET, FILM COATED 100 mg ORAL ANDA 30 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0904-6924 TABLET, FILM COATED 25 mg ORAL ANDA 30 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0904-6925 TABLET, FILM COATED 50 mg ORAL ANDA 30 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0904-6926 TABLET, FILM COATED 100 mg ORAL ANDA 30 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10135-694 SOLUTION 20 mg ORAL ANDA 28 sections