sertraline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
serotonin reuptake inhibitors 2436 79617-96-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sertraline
  • sertraline hydrochloride
  • sertraline HCl
A selective serotonin uptake inhibitor that is used in the treatment of depression.
  • Molecular weight: 306.23
  • Formula: C17H17Cl2N
  • CLOGP: 5.35
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 1
  • TPSA: 12.03
  • ALOGS: -6.32
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 3.80 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.20 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 9.33 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 44 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Dec. 30, 1991 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intentional self-injury 1141.66 9.58 866 207853 22246 50374159
Intentional overdose 942.68 9.58 1224 207495 61280 50335125
Serotonin syndrome 808.11 9.58 729 207990 23984 50372421
Suicidal ideation 728.69 9.58 1015 207704 54370 50342035
Suicide attempt 713.60 9.58 970 207749 50762 50345643
Drug abuse 623.54 9.58 983 207736 58863 50337542
Anxiety 454.19 9.58 1686 207033 175920 50220485
Synovitis 411.01 9.58 25 208694 123840 50272565
Contraindicated product administered 390.87 9.58 71 208648 148887 50247518
Drug interaction 384.36 9.58 1736 206983 197885 50198520
Agitation 373.01 9.58 736 207983 52648 50343757
Systemic lupus erythematosus 364.72 9.58 69 208650 140553 50255852
Hand deformity 359.18 9.58 12 208707 100187 50296218
Drug intolerance 329.61 9.58 253 208466 218851 50177554
Completed suicide 320.27 9.58 1232 207487 130657 50265748
Treatment failure 314.32 9.58 89 208630 137548 50258857
Joint swelling 305.31 9.58 337 208382 244949 50151456
Tremor 299.41 9.58 1098 207621 113805 50282600
Glossodynia 294.81 9.58 59 208660 115510 50280895
Rheumatoid arthritis 293.18 9.58 243 208476 202307 50194098
Akathisia 279.28 9.58 248 208471 7981 50388424
Infusion related reaction 268.96 9.58 185 208534 169372 50227033
Arthropathy 258.93 9.58 166 208553 157740 50238665
Toxicity to various agents 255.43 9.58 1624 207095 210875 50185530
Drug ineffective 253.47 9.58 2166 206553 817167 49579238
Withdrawal syndrome 248.69 9.58 334 208385 17256 50379149
Depression 247.80 9.58 1340 207379 164083 50232322
Abnormal behaviour 230.07 9.58 341 208378 19317 50377088
Alopecia 228.04 9.58 414 208305 244633 50151772
Pericarditis 214.05 9.58 34 208685 78655 50317750
Sopor 213.06 9.58 331 208388 19548 50376857
Hallucination 207.84 9.58 538 208181 46119 50350286
Panic attack 204.43 9.58 320 208399 19022 50377383
Swelling 199.97 9.58 325 208394 200547 50195858
Aggression 183.66 9.58 320 208399 20796 50375609
Mania 182.11 9.58 225 208494 10691 50385714
Therapeutic product effect decreased 177.96 9.58 179 208540 135871 50260534
Bruxism 177.31 9.58 126 208593 2914 50393491
Overdose 175.87 9.58 846 207873 98881 50297524
Rash 173.91 9.58 1075 207644 436396 49960009
Wound 172.28 9.58 112 208607 105682 50290723
Arthralgia 166.19 9.58 1094 207625 437608 49958797
Abdominal discomfort 164.21 9.58 454 208265 231187 50165218
Hallucination, auditory 162.91 9.58 211 208508 10517 50385888
Hepatic enzyme increased 162.88 9.58 196 208523 137184 50259221
Somnolence 157.03 9.58 1136 207583 153849 50242556
Mydriasis 156.69 9.58 206 208513 10421 50385984
Restlessness 154.40 9.58 329 208390 24844 50371561
Hyponatraemia 154.22 9.58 794 207925 95345 50301060
Duodenal ulcer perforation 148.85 9.58 10 208709 45601 50350804
Rheumatoid factor positive 146.35 9.58 17 208702 49842 50346563
Off label use 145.53 9.58 1255 207464 473171 49923234
Paranoia 145.52 9.58 196 208523 10152 50386253
Helicobacter infection 143.29 9.58 18 208701 49684 50346721
Nasopharyngitis 140.54 9.58 373 208346 192554 50203851
Psychotic disorder 137.16 9.58 288 208431 21524 50374881
Extrapyramidal disorder 134.61 9.58 202 208517 11568 50384837
Self-injurious ideation 131.42 9.58 93 208626 2136 50394269
Peripheral swelling 131.23 9.58 424 208295 205512 50190893
Product use issue 129.75 9.58 263 208456 149212 50247193
Hypersensitivity 127.59 9.58 457 208262 214704 50181701
Folliculitis 126.84 9.58 9 208710 39216 50357189
Drug withdrawal syndrome 125.10 9.58 302 208417 24779 50371626
Discomfort 118.76 9.58 164 208555 108216 50288189
Dyskinesia 118.67 9.58 316 208403 27545 50368860
Disorientation 117.79 9.58 368 208351 35116 50361289
Anger 117.67 9.58 186 208533 11147 50385258
Tic 116.86 9.58 69 208650 1148 50395257
Electrocardiogram QT prolonged 116.30 9.58 473 208246 51413 50344992
Depressed mood 114.93 9.58 355 208364 33668 50362737
Insomnia 113.91 9.58 1162 207557 173703 50222702
Delusion 111.87 9.58 175 208544 10394 50386011
Crying 111.82 9.58 255 208464 20161 50376244
Disturbance in attention 110.59 9.58 331 208388 30855 50365550
Galactorrhoea 110.32 9.58 104 208615 3619 50392786
Pyrexia 110.17 9.58 1020 207699 379183 50017222
Confusional state 109.18 9.58 1210 207509 184718 50211687
Dizziness 108.83 9.58 2019 206700 344350 50052055
Irritability 108.75 9.58 310 208409 28116 50368289
Muscle injury 105.62 9.58 14 208705 37097 50359308
Stomatitis 105.47 9.58 159 208560 101185 50295220
Pain 103.61 9.58 1723 206996 577180 49819225
Infection 102.72 9.58 367 208352 172587 50223818
Seizure 100.93 9.58 831 207888 117043 50279362
Myoclonus 100.38 9.58 199 208520 14271 50382134
Homicidal ideation 100.32 9.58 71 208648 1631 50394774
Apathy 97.16 9.58 137 208582 7411 50388994
Febrile neutropenia 96.16 9.58 159 208560 97508 50298897
Feeling abnormal 95.56 9.58 862 207857 124630 50271775
Lower respiratory tract infection 93.72 9.58 155 208564 95046 50301359
Thinking abnormal 92.48 9.58 152 208567 9415 50386990
Muscle rigidity 92.11 9.58 154 208565 9675 50386730
Nightmare 88.18 9.58 201 208518 15885 50380520
Malignant neoplasm progression 86.35 9.58 92 208627 68032 50328373
Inappropriate antidiuretic hormone secretion 85.51 9.58 176 208543 12967 50383438
Impaired healing 85.41 9.58 97 208622 69689 50326716
Blister 85.08 9.58 138 208581 85280 50311125
Sinusitis 84.24 9.58 389 208330 170169 50226236
Emotional distress 84.07 9.58 285 208434 28378 50368027
Poisoning deliberate 83.73 9.58 131 208588 7781 50388624
Psychomotor hyperactivity 83.55 9.58 143 208576 9158 50387247
Hyperreflexia 82.97 9.58 104 208615 5014 50391391
Mood swings 81.60 9.58 194 208525 15760 50380645
Hyperhidrosis 81.18 9.58 639 208080 88787 50307618
Loss of consciousness 81.07 9.58 720 207999 103633 50292772
Hallucinations, mixed 80.71 9.58 92 208627 4011 50392394
C-reactive protein abnormal 80.33 9.58 10 208709 27799 50368606
Dystonia 80.31 9.58 162 208557 11764 50384641
Homicide 79.13 9.58 36 208683 336 50396069
C-reactive protein increased 78.56 9.58 95 208624 66379 50330026
Product substitution issue 77.45 9.58 176 208543 13881 50382524
Delirium 76.13 9.58 336 208383 37856 50358549
Hyperprolactinaemia 75.78 9.58 81 208638 3284 50393121
Treatment noncompliance 74.96 9.58 284 208435 29866 50366539
Anorgasmia 73.87 9.58 39 208680 516 50395889
General physical health deterioration 73.24 9.58 320 208399 142114 50254291
Suicidal behaviour 72.63 9.58 67 208652 2267 50394138
Foetal exposure during pregnancy 72.44 9.58 263 208456 27096 50369309
Neutropenia 72.15 9.58 339 208380 147626 50248779
Hallucination, visual 71.54 9.58 189 208530 16393 50380012
Social avoidant behaviour 71.39 9.58 72 208647 2725 50393680
Mental disorder 70.16 9.58 225 208494 21766 50374639
Renal impairment 70.07 9.58 128 208591 75533 50320872
Poisoning 68.90 9.58 156 208563 12273 50384132
Oromandibular dystonia 67.45 9.58 34 208685 406 50395999
Infarction 67.01 9.58 64 208655 2264 50394141
Drug dependence 66.56 9.58 206 208513 19553 50376852
Abnormal dreams 66.30 9.58 130 208589 9247 50387158
Libido decreased 65.91 9.58 64 208655 2312 50394093
Salivary hypersecretion 65.44 9.58 106 208613 6485 50389920
Neuroleptic malignant syndrome 65.41 9.58 143 208576 10987 50385418
Muscle twitching 64.67 9.58 174 208545 15257 50381148
Hypomania 64.36 9.58 86 208633 4419 50391986
Parkinsonism 64.19 9.58 124 208595 8723 50387682
Obsessive-compulsive disorder 64.19 9.58 74 208645 3266 50393139
Tardive dyskinesia 64.18 9.58 111 208608 7168 50389237
Emotional disorder 63.89 9.58 147 208572 11689 50384716
Maculopathy 62.07 9.58 57 208662 1917 50394488
Ill-defined disorder 61.56 9.58 81 208638 54573 50341832
Formication 60.57 9.58 75 208644 3571 50392834
Activation syndrome 60.05 9.58 25 208694 184 50396221
Impulsive behaviour 59.81 9.58 49 208670 1409 50394996
Product complaint 59.26 9.58 140 208579 11326 50385079
Dysarthria 58.59 9.58 307 208412 37096 50359309
Thrombocytopenia 57.36 9.58 301 208418 127372 50269033
Hip arthroplasty 57.04 9.58 27 208692 30402 50366003
Bradykinesia 55.92 9.58 75 208644 3868 50392537
Trismus 55.82 9.58 69 208650 3279 50393126
Colitis microscopic 55.63 9.58 98 208621 6422 50389983
Drug screen false positive 54.95 9.58 37 208682 782 50395623
Agitation neonatal 54.91 9.58 31 208688 472 50395933
Pancytopenia 54.85 9.58 171 208548 83859 50312546
Psychomotor retardation 54.69 9.58 69 208650 3349 50393056
Stiff person syndrome 54.39 9.58 24 208695 207 50396198
Major depression 54.31 9.58 100 208619 6784 50389621
Irritable bowel syndrome 54.18 9.58 80 208639 51361 50345044
Flat affect 53.83 9.58 44 208675 1261 50395144
Newborn persistent pulmonary hypertension 53.64 9.58 21 208698 129 50396276
Generalised tonic-clonic seizure 53.60 9.58 233 208486 26077 50370328
Blood prolactin increased 53.50 9.58 65 208654 3034 50393371
Gestational diabetes 53.39 9.58 104 208615 7361 50389044
Amenorrhoea 53.31 9.58 112 208607 8372 50388033
Gastrointestinal disorder 53.04 9.58 205 208514 94251 50302154
Knee arthroplasty 53.02 9.58 42 208677 35804 50360601
Persistent genital arousal disorder 52.39 9.58 24 208695 228 50396177
Mental impairment 51.68 9.58 137 208582 11907 50384498
Mucosal inflammation 51.09 9.58 54 208665 40088 50356317
Bradyphrenia 50.60 9.58 91 208628 6061 50390344
Yawning 50.59 9.58 37 208682 896 50395509
Euphoric mood 49.84 9.58 72 208647 3983 50392422
Mood altered 48.56 9.58 139 208580 12634 50383771
Negative thoughts 48.45 9.58 35 208684 831 50395574
Cytomegalovirus infection 48.29 9.58 8 208711 17954 50378451
Psychotic symptom 48.19 9.58 40 208679 1172 50395233
Memory impairment 48.11 9.58 520 208199 78840 50317565
Tachycardia 47.84 9.58 625 208094 99138 50297267
Death 47.83 9.58 1001 207718 324378 50072027
Abnormal weight gain 47.76 9.58 43 208676 1409 50394996
Reversible cerebral vasoconstriction syndrome 47.71 9.58 51 208668 2068 50394337
Fear 46.54 9.58 149 208570 14400 50382005
Intrusive thoughts 46.40 9.58 20 208699 162 50396243
Eye movement disorder 46.36 9.58 74 208645 4471 50391934
Drug withdrawal syndrome neonatal 46.27 9.58 47 208672 1794 50394611
Inflammation 46.11 9.58 104 208615 56808 50339597
Burning mouth syndrome 45.99 9.58 26 208693 397 50396008
Alcoholism 45.62 9.58 44 208675 1576 50394829
Depressed level of consciousness 45.35 9.58 368 208351 51585 50344820
Intentional product use issue 45.09 9.58 164 208555 76754 50319651
Respiratory arrest 44.07 9.58 242 208477 29767 50366638
Cardiac failure 44.00 9.58 163 208556 75877 50320528
Loss of libido 43.78 9.58 38 208681 1185 50395220
Disease progression 43.61 9.58 225 208494 95641 50300764
Cholecystitis chronic 43.55 9.58 112 208607 9557 50386848
Acute kidney injury 43.15 9.58 671 208048 227387 50169018
Abulia 43.09 9.58 25 208694 402 50396003
Drug screen positive 42.68 9.58 61 208658 3341 50393064
Pleurothotonus 41.75 9.58 38 208681 1263 50395142
Emotional poverty 41.68 9.58 22 208697 291 50396114
Tension 41.43 9.58 54 208665 2708 50393697
Flashback 41.32 9.58 17 208702 121 50396284
Torticollis 41.25 9.58 43 208676 1693 50394712
Schizophrenia 41.18 9.58 93 208626 7304 50389101
Fall 40.75 9.58 1729 206990 333203 50063202
Drowning 40.66 9.58 24 208695 399 50396006
Amnesia 40.56 9.58 306 208413 41954 50354451
Musculoskeletal stiffness 40.02 9.58 338 208381 128143 50268262
Balance disorder 39.80 9.58 456 208263 70134 50326271
Arthritis 39.19 9.58 204 208515 86517 50309888
Restless legs syndrome 38.89 9.58 149 208570 15748 50380657
Injection site pain 38.80 9.58 283 208436 110741 50285664
Sensation of foreign body 38.67 9.58 63 208656 3873 50392532
Pruritus 38.59 9.58 883 207836 282685 50113720
Depersonalisation/derealisation disorder 38.47 9.58 35 208684 1163 50395242
Cardiac arrest 38.41 9.58 520 208199 83131 50313274
Catatonia 38.35 9.58 61 208658 3675 50392730
Depressive symptom 38.14 9.58 56 208663 3144 50393261
Cycloplegia 37.88 9.58 9 208710 3 50396402
Therapeutic product effect incomplete 37.68 9.58 222 208497 91293 50305112
Conjunctival abrasion 37.45 9.58 11 208708 22 50396383
Vertigo 37.36 9.58 352 208367 51480 50344925
Speech disorder 37.33 9.58 263 208456 35285 50361120
Sedation 37.29 9.58 235 208484 30375 50366030
Musculoskeletal pain 37.17 9.58 162 208557 72015 50324390
Hypersomnia 37.03 9.58 143 208576 15171 50381234
Affective disorder 36.84 9.58 72 208647 5109 50391296
Anhedonia 36.55 9.58 104 208615 9420 50386985
Psoriatic arthropathy 36.45 9.58 88 208631 46944 50349461
Retroplacental haematoma 36.36 9.58 16 208703 137 50396268
Paraesthesia 35.91 9.58 696 208023 119547 50276858
Tremor neonatal 35.36 9.58 14 208705 89 50396316
Pneumonia 35.26 9.58 1242 207477 377159 50019246
Syncope 34.51 9.58 607 208112 102395 50294010
Pregnancy with implant contraceptive 34.23 9.58 42 208677 1981 50394424
Intentional product misuse 34.00 9.58 318 208401 46416 50349989
Cerebral vasoconstriction 33.86 9.58 30 208689 962 50395443
Anaemia 33.80 9.58 788 207931 251668 50144737
Sepsis 33.62 9.58 368 208351 132557 50263848
Eosinophilic pneumonia acute 33.55 9.58 19 208700 291 50396114
Psychomotor skills impaired 33.55 9.58 42 208677 2022 50394383
Clonus 33.38 9.58 61 208658 4114 50392291
Hyponatraemic seizure 33.31 9.58 21 208698 395 50396010
Hallucination, olfactory 33.15 9.58 17 208702 211 50396194
Rabbit syndrome 32.99 9.58 19 208700 301 50396104
Pleural effusion 32.79 9.58 199 208520 81255 50315150
Palpitations 32.77 9.58 560 208159 93946 50302459
Pain in extremity 32.67 9.58 866 207853 271999 50124406
Heavy menstrual bleeding 31.95 9.58 138 208581 15399 50381006
Disorganised speech 31.91 9.58 29 208690 962 50395443
Neuropathy peripheral 31.74 9.58 251 208468 96506 50299899
Uterine perforation 31.72 9.58 77 208642 6338 50390067
Therapeutic response unexpected 31.70 9.58 140 208579 15775 50380630
Somatic symptom disorder of pregnancy 31.66 9.58 13 208706 92 50396313
Septic shock 31.50 9.58 125 208594 57050 50339355
Rhabdomyolysis 31.17 9.58 271 208448 38756 50357649
Victim of chemical submission 30.87 9.58 17 208702 246 50396159
Neonatal asphyxia 30.82 9.58 16 208703 204 50396201
Tinnitus 30.64 9.58 210 208509 27922 50368483
Mental status changes 30.62 9.58 255 208464 36017 50360388
Disturbance in sexual arousal 30.61 9.58 12 208707 74 50396331
Vision blurred 30.60 9.58 475 208244 78172 50318233
Schizoaffective disorder bipolar type 30.41 9.58 13 208706 103 50396302
Bipolar disorder 30.15 9.58 78 208641 6679 50389726
Conversion disorder 30.07 9.58 35 208684 1561 50394844
Lethargy 30.00 9.58 324 208395 49108 50347297
Nystagmus 29.94 9.58 69 208650 5492 50390913
Bipolar I disorder 29.79 9.58 34 208685 1484 50394921
Phobia 29.74 9.58 18 208701 314 50396091
Bradycardia neonatal 29.71 9.58 26 208693 820 50395585
Bone erosion 29.71 9.58 6 208713 11681 50384724
Injection site erythema 29.68 9.58 184 208535 74752 50321653
Neonatal respiratory distress syndrome 29.56 9.58 45 208674 2609 50393796
Herpes zoster 29.52 9.58 171 208548 70615 50325790
Central vision loss 29.51 9.58 8 208711 10 50396395
Poverty of thought content 29.51 9.58 8 208711 10 50396395
Psychiatric symptom 29.49 9.58 61 208658 4509 50391896
Foaming at mouth 29.29 9.58 29 208690 1073 50395332
Platelet count decreased 29.14 9.58 270 208449 100456 50295949
Pancreatic fibrosis 29.09 9.58 12 208707 86 50396319
Skin ulcer 29.05 9.58 64 208655 35254 50361151
Coordination abnormal 28.95 9.58 109 208610 11425 50384980
Dyspnoea 28.53 9.58 1911 206808 545697 49850708
Alcohol poisoning 28.26 9.58 36 208683 1764 50394641
Hyponatraemic syndrome 28.21 9.58 21 208698 523 50395882
Bone marrow failure 28.08 9.58 44 208675 27580 50368825
Borderline personality disorder 27.97 9.58 23 208696 665 50395740
Depression suicidal 27.92 9.58 33 208686 1496 50394909
Idiopathic intracranial hypertension 27.84 9.58 41 208678 2308 50394097
Suppressed lactation 27.75 9.58 19 208700 413 50395992
Cardio-respiratory arrest 27.68 9.58 342 208377 53550 50342855
Respiratory disorder neonatal 27.33 9.58 26 208693 915 50395490
Basal cell carcinoma 26.93 9.58 34 208685 23322 50373083
Violence-related symptom 26.75 9.58 18 208701 380 50396025
Alcohol abuse 26.71 9.58 36 208683 1865 50394540
Leukopenia 26.64 9.58 166 208553 67362 50329043
Hereditary angioedema 26.56 9.58 65 208654 5377 50391028
Cough 26.48 9.58 775 207944 240489 50155916
Nervousness 26.41 9.58 200 208519 27451 50368954
Neutrophil count decreased 26.40 9.58 99 208620 45927 50350478
Confabulation 26.39 9.58 16 208703 280 50396125
Urinary incontinence 26.36 9.58 203 208516 28005 50368400
Upper gastrointestinal haemorrhage 26.07 9.58 133 208586 15902 50380503
Device dislocation 25.99 9.58 165 208554 21381 50375024
Hemivertebra 25.92 9.58 12 208707 117 50396288
Antisocial behaviour 25.80 9.58 16 208703 292 50396113
Blood creatinine increased 25.71 9.58 196 208523 75964 50320441
Perinatal depression 25.45 9.58 20 208699 541 50395864
Somnambulism 25.31 9.58 60 208659 4864 50391541
Injection site bruising 25.29 9.58 73 208646 36695 50359710
Maternal drugs affecting foetus 25.17 9.58 61 208658 5016 50391389
White blood cell count decreased 25.00 9.58 335 208384 116387 50280018
Pulmonary embolism 24.93 9.58 572 208147 101132 50295273
Caesarean section 24.92 9.58 129 208590 15510 50380895
Inappropriate affect 24.79 9.58 23 208696 784 50395621
Maternal exposure during pregnancy 24.77 9.58 487 208232 159291 50237114
Food interaction 24.74 9.58 21 208698 635 50395770
Lung disorder 24.64 9.58 98 208621 44701 50351704
Device placement issue 24.57 9.58 23 208696 793 50395612
Fatigue 24.50 9.58 2551 206168 705050 49691355
Neutropenic sepsis 24.37 9.58 14 208705 14133 50382272
Hypotonia neonatal 24.24 9.58 25 208694 972 50395433
Dysphemia 24.15 9.58 38 208681 2268 50394137
Muscle tightness 24.05 9.58 95 208624 10185 50386220
Factor XIII deficiency 23.97 9.58 10 208709 74 50396331
Respiratory tract infection 23.95 9.58 61 208658 31956 50364449
Mutism 23.90 9.58 29 208690 1352 50395053
Large for dates baby 23.88 9.58 18 208701 457 50395948
Intermenstrual bleeding 23.84 9.58 72 208647 6742 50389663
Osteoporosis 23.55 9.58 100 208619 44779 50351626
Embedded device 23.38 9.58 42 208677 2795 50393610
Incoherent 23.34 9.58 53 208666 4177 50392228
Mobility decreased 23.26 9.58 214 208505 79734 50316671
Herbal interaction 23.10 9.58 10 208709 82 50396323
Antipsychotic drug level increased 23.08 9.58 44 208675 3065 50393340
Tachyphrenia 22.95 9.58 27 208692 1218 50395187
Haemophagocytic lymphohistiocytosis 22.86 9.58 4 208715 8629 50387776
Red blood cell sedimentation rate increased 22.82 9.58 55 208664 29361 50367044
Obsessive thoughts 22.78 9.58 18 208701 491 50395914
Swollen tongue 22.44 9.58 198 208521 28432 50367973
Dissociative disorder 22.24 9.58 13 208706 212 50396193
Abortion missed 22.21 9.58 30 208689 1558 50394847
Persistent foetal circulation 22.19 9.58 13 208706 213 50396192
Tuberculosis 22.12 9.58 7 208712 10076 50386329
Transient psychosis 21.96 9.58 8 208711 39 50396366
Adrenal insufficiency 21.94 9.58 16 208703 14227 50382178
Coma 21.92 9.58 343 208376 56536 50339869
Sleep-related eating disorder 21.89 9.58 21 208698 747 50395658
Hallucination, gustatory 21.88 9.58 9 208710 64 50396341
Injection site pruritus 21.85 9.58 89 208630 40322 50356083
Unresponsive to stimuli 21.62 9.58 207 208512 30402 50366003
Mitochondrial encephalomyopathy 21.61 9.58 7 208712 22 50396383
Creatinine renal clearance decreased 21.57 9.58 11 208708 11870 50384535
Environmental exposure 21.53 9.58 9 208710 67 50396338
Cold sweat 21.48 9.58 94 208625 10550 50385855
Soliloquy 21.41 9.58 12 208707 180 50396225
Rheumatoid nodule 21.38 9.58 13 208706 12722 50383683
Alcohol intolerance 21.30 9.58 9 208710 69 50396336
Foreign body in reproductive tract 21.26 9.58 17 208702 472 50395933
Hypersensitivity pneumonitis 21.25 9.58 36 208683 2286 50394119
Diplopia 21.11 9.58 144 208575 19116 50377289
Impaired reasoning 21.08 9.58 9 208710 71 50396334
Self esteem decreased 21.02 9.58 18 208701 551 50395854
Drug hypersensitivity 20.98 9.58 1250 207469 249760 50146645
Amniotic fluid volume increased 20.81 9.58 11 208708 146 50396259
Neoplasm progression 20.71 9.58 57 208662 29100 50367305
Judgement impaired 20.69 9.58 18 208701 563 50395842
Pneumocystis jirovecii pneumonia 20.67 9.58 18 208701 14645 50381760
Right ventricular hypertrophy 20.59 9.58 19 208700 643 50395762
Anaphylactic shock 20.59 9.58 32 208687 20123 50376282
Post-traumatic stress disorder 20.59 9.58 51 208668 4252 50392153
Parkinsonian gait 20.58 9.58 16 208703 426 50395979
Urine sodium decreased 20.55 9.58 11 208708 150 50396255
Injury 20.39 9.58 299 208420 48626 50347779
Bundle branch block right 20.09 9.58 53 208666 4592 50391813
Drug eruption 20.06 9.58 42 208677 23564 50372841
Hypochloraemia 19.89 9.58 29 208690 1618 50394787
Stress 19.83 9.58 322 208397 53471 50342934
Erythromelalgia 19.72 9.58 10 208709 121 50396284
Thermal burn 19.70 9.58 54 208665 4787 50391618
Brain injury 19.61 9.58 62 208657 5952 50390453
Tongue spasm 19.56 9.58 8 208711 56 50396349
Congenital brain damage 19.55 9.58 5 208714 4 50396401
Exposure during pregnancy 19.55 9.58 645 208074 120370 50276035
Flight of ideas 19.54 9.58 14 208705 328 50396077
Drug resistance 19.54 9.58 30 208689 18959 50377446
Complication of device insertion 19.44 9.58 62 208657 5979 50390426
Small for dates baby 19.43 9.58 44 208675 3461 50392944
Haematoma muscle 19.06 9.58 19 208700 709 50395696
Femur-fibula-ulna complex 19.03 9.58 5 208714 5 50396400
Tearfulness 19.03 9.58 45 208674 3642 50392763
Sexual dysfunction 19.01 9.58 42 208677 3250 50393155
Gallbladder cholesterolosis 18.97 9.58 19 208700 713 50395692
Panic disorder 18.86 9.58 34 208685 2269 50394136
Cataract 18.80 9.58 116 208603 47184 50349221
Delusion of reference 18.74 9.58 9 208710 96 50396309
Miosis 18.73 9.58 63 208656 6247 50390158
Menstruation irregular 18.71 9.58 62 208657 6100 50390305
Polymenorrhoea 18.69 9.58 23 208696 1088 50395317
Posture abnormal 18.61 9.58 32 208687 2057 50394348
Affect lability 18.56 9.58 80 208639 8918 50387487
Multiple sclerosis relapse 18.47 9.58 264 208455 42700 50353705
Long QT syndrome 18.44 9.58 39 208680 2928 50393477
Negative symptoms in schizophrenia 18.27 9.58 9 208710 102 50396303
Maternal exposure during breast feeding 18.21 9.58 41 208678 3213 50393192
Metabolic syndrome 18.16 9.58 25 208694 1322 50395083
Neonatal seizure 18.16 9.58 14 208705 368 50396037
Ophthalmic vein thrombosis 18.14 9.58 10 208709 145 50396260
Target skin lesion 18.04 9.58 9 208710 105 50396300
Catastrophic reaction 18.03 9.58 6 208713 21 50396384
Intracranial meningioma malignant 17.98 9.58 4 208715 0 50396405
Slow response to stimuli 17.97 9.58 20 208699 849 50395556
Renal dysplasia 17.96 9.58 10 208709 148 50396257
Ductus arteriosus premature closure 17.84 9.58 13 208706 313 50396092
Athetosis 17.82 9.58 6 208713 22 50396383
Palmar-plantar erythrodysaesthesia syndrome 17.72 9.58 35 208684 20063 50376342
Dissociation 17.72 9.58 33 208686 2258 50394147
Lack of spontaneous speech 17.67 9.58 10 208709 153 50396252
Suicide threat 17.61 9.58 6 208713 23 50396382
Persistent depressive disorder 17.56 9.58 20 208699 871 50395534
Hyperkalaemia 17.56 9.58 121 208598 47968 50348437
Infantile vomiting 17.53 9.58 9 208710 112 50396293
Urinary retention 17.46 9.58 175 208544 26015 50370390
Congenital skin dimples 17.46 9.58 9 208710 113 50396292
Tenosynovitis 17.44 9.58 11 208708 10554 50385851
Water intoxication 17.40 9.58 14 208705 392 50396013
Vanishing bile duct syndrome 17.37 9.58 17 208702 620 50395785
Injection site swelling 17.36 9.58 101 208618 41672 50354733
Personality disorder 17.36 9.58 48 208671 4276 50392129
Photophobia 17.33 9.58 113 208606 14774 50381631
Urine chloride decreased 17.28 9.58 8 208711 78 50396327
Product taste abnormal 17.24 9.58 28 208691 1717 50394688
Heat stroke 17.24 9.58 17 208702 626 50395779
Bronchopulmonary aspergillosis 17.14 9.58 5 208714 7587 50388818
Somatic delusion 17.13 9.58 16 208703 550 50395855
CYP3A4 polymorphism 17.11 9.58 8 208711 80 50396325
Hypercalcaemia 17.08 9.58 45 208674 23307 50373098
Alcohol use 17.04 9.58 30 208689 1965 50394440
Hepatic function abnormal 17.03 9.58 73 208646 32608 50363797
Dopamine dysregulation syndrome 16.96 9.58 10 208709 166 50396239
Therapy non-responder 16.89 9.58 132 208587 50890 50345515
Ataxia 16.89 9.58 106 208613 13680 50382725
Illness anxiety disorder 16.86 9.58 9 208710 122 50396283
Vomiting 16.76 9.58 2157 206562 458601 49937804
Libido disorder 16.64 9.58 7 208712 53 50396352
Blood creatine phosphokinase increased 16.54 9.58 174 208545 26193 50370212
Action tremor 16.43 9.58 12 208707 290 50396115
Phalangeal hypoplasia 16.41 9.58 5 208714 12 50396393
Myelosuppression 16.30 9.58 19 208700 13498 50382907
Tongue discolouration 16.27 9.58 36 208683 2788 50393617
Postural orthostatic tachycardia syndrome 16.22 9.58 19 208700 853 50395552
Pelvic pain 16.17 9.58 90 208629 11123 50385282
Logorrhoea 16.16 9.58 32 208687 2292 50394113
Lipidosis 16.12 9.58 5 208714 13 50396392
Alkalosis hypochloraemic 16.12 9.58 9 208710 134 50396271
Visceral congestion 16.08 9.58 12 208707 300 50396105
Partner stress 16.08 9.58 12 208707 300 50396105
Delusional disorder, unspecified type 16.04 9.58 13 208706 368 50396037
Myocardial fibrosis 15.95 9.58 17 208702 687 50395718
Gallbladder injury 15.94 9.58 23 208696 1271 50395134
Hypertonia 15.85 9.58 44 208675 3929 50392476
Ascites 15.83 9.58 85 208634 35776 50360629
Substance abuse 15.79 9.58 45 208674 4079 50392326
Morbid thoughts 15.79 9.58 15 208704 527 50395878
Sluggishness 15.79 9.58 47 208672 4366 50392039
Drug dose titration not performed 15.77 9.58 14 208705 450 50395955
Glucose tolerance impaired in pregnancy 15.75 9.58 4 208715 3 50396402
Petit mal epilepsy 15.75 9.58 39 208680 3250 50393155
Drug reaction with eosinophilia and systemic symptoms 15.75 9.58 62 208657 28362 50368043
Diaphragmatic rupture 15.72 9.58 11 208708 248 50396157
Dry mouth 15.69 9.58 322 208397 55856 50340549
Economic problem 15.69 9.58 28 208691 1854 50394551
Muscle contracture 15.67 9.58 22 208697 1185 50395220
Electrocardiogram T wave abnormal 15.64 9.58 31 208688 2222 50394183
Physical assault 15.60 9.58 19 208700 889 50395516
Oral discomfort 15.57 9.58 70 208649 7947 50388458
Social anxiety disorder 15.46 9.58 13 208706 388 50396017
Peritonitis 15.43 9.58 25 208694 15461 50380944
Suspiciousness 15.42 9.58 12 208707 320 50396085
Teratoma benign 15.33 9.58 7 208712 66 50396339
Weight increased 15.30 9.58 997 207722 200894 50195511
Metastases to bone 15.30 9.58 32 208687 17963 50378442
Distractibility 15.29 9.58 13 208706 394 50396011
Device expulsion 15.27 9.58 184 208535 28638 50367767
Biliary dyskinesia 15.25 9.58 33 208686 2517 50393888
Compulsions 15.24 9.58 10 208709 202 50396203
Nephropathy toxic 15.24 9.58 7 208712 8022 50388383
Localised infection 15.15 9.58 54 208665 25431 50370974
Snoring 15.03 9.58 39 208680 3345 50393060
Diverticulitis 15.01 9.58 78 208641 33104 50363301
Screaming 15.00 9.58 36 208683 2942 50393463
Derealisation 14.99 9.58 20 208699 1026 50395379
Hypokalaemia 14.99 9.58 472 208247 87520 50308885
Osteonecrosis of jaw 14.97 9.58 76 208643 32450 50363955
Hypoaesthesia eye 14.97 9.58 7 208712 70 50396335
Postural tremor 14.86 9.58 10 208709 211 50396194
Marital problem 14.82 9.58 9 208710 158 50396247
Lip blister 14.78 9.58 28 208691 1941 50394464
Thrombotic microangiopathy 14.72 9.58 9 208710 8782 50387623
Attention-seeking behaviour 14.71 9.58 7 208712 73 50396332
Atrioventricular dissociation 14.66 9.58 10 208709 216 50396189
Grip strength decreased 14.66 9.58 17 208702 12104 50384301
Serum serotonin increased 14.62 9.58 9 208710 162 50396243
Complication of device removal 14.57 9.58 44 208675 4120 50392285
Infantile apnoea 14.57 9.58 18 208701 855 50395550
Transplant rejection 14.54 9.58 11 208708 9598 50386807
Spleen congestion 14.51 9.58 8 208711 116 50396289
May-Thurner syndrome 14.51 9.58 5 208714 20 50396385
Fear of weight gain 14.51 9.58 5 208714 20 50396385
Postpartum haemorrhage 14.50 9.58 26 208693 1728 50394677
Drug tolerance decreased 14.49 9.58 10 208709 9150 50387255
Joint hyperextension 14.44 9.58 11 208708 284 50396121
Accommodation disorder 14.42 9.58 12 208707 353 50396052
Acute myeloid leukaemia 14.40 9.58 25 208694 15049 50381356
Collagen-vascular disease 14.39 9.58 7 208712 77 50396328
Hypercapnic coma 14.34 9.58 9 208710 168 50396237
Asocial behaviour 14.32 9.58 5 208714 21 50396384
Pulmonary infarction 14.31 9.58 31 208688 2367 50394038
Gross motor delay 14.22 9.58 8 208711 121 50396284
Feeling guilty 14.18 9.58 14 208705 516 50395889
Leukaemoid reaction 14.06 9.58 9 208710 174 50396231
Cognitive disorder 14.05 9.58 258 208461 43865 50352540
Pre-eclampsia 13.98 9.58 68 208651 7976 50388429
Loss of personal independence in daily activities 13.94 9.58 204 208515 69846 50326559
Tunnel vision 13.94 9.58 16 208703 703 50395702
Wrong patient 13.93 9.58 7 208712 83 50396322
Chorea 13.92 9.58 22 208697 1318 50395087
Metastases to lung 13.83 9.58 15 208704 11005 50385400
Blood pressure diastolic abnormal 13.80 9.58 11 208708 9350 50387055
Female orgasmic disorder 13.77 9.58 6 208713 50 50396355
Menopausal disorder 13.77 9.58 6 208713 50 50396355
Drug monitoring procedure incorrectly performed 13.77 9.58 8 208711 129 50396276
Rectal cancer metastatic 13.75 9.58 10 208709 240 50396165
Psychogenic seizure 13.75 9.58 24 208695 1561 50394844
Morning sickness 13.72 9.58 15 208704 624 50395781
Neoplasm malignant 13.61 9.58 51 208668 23664 50372741
Blood calcium decreased 13.60 9.58 42 208677 20664 50375741
Dysphoria 13.58 9.58 47 208672 4727 50391678
Neonatal tachypnoea 13.57 9.58 6 208713 52 50396353
Cardiotoxicity 13.53 9.58 6 208713 7021 50389384
COVID-19 13.52 9.58 125 208594 46537 50349868
Erythema 13.49 9.58 481 208238 145933 50250472
Postictal headache 13.49 9.58 3 208716 0 50396405
Anaplastic large cell lymphoma T- and null-cell types stage IV 13.49 9.58 3 208716 0 50396405
Analgesic drug level increased 13.47 9.58 25 208694 1706 50394699
Vasodilation procedure 13.46 9.58 5 208714 26 50396379
Foetal death 13.40 9.58 68 208651 8112 50388293
Opisthotonus 13.38 9.58 11 208708 318 50396087
Multiple sclerosis 13.22 9.58 136 208583 20357 50376048
Hypokinesia 13.18 9.58 91 208628 12126 50384279
Impulse-control disorder 13.14 9.58 15 208704 655 50395750
Congenital tricuspid valve incompetence 13.10 9.58 7 208712 95 50396310
Laryngomalacia 13.10 9.58 6 208713 57 50396348
Product odour abnormal 13.06 9.58 19 208700 1058 50395347
Decreased activity 13.00 9.58 49 208670 5138 50391267
Myoclonic epilepsy 13.00 9.58 18 208701 957 50395448
Urinary hesitation 13.00 9.58 27 208692 2002 50394403
Gambling disorder 12.96 9.58 20 208699 1174 50395231
Decreased interest 12.92 9.58 34 208685 2942 50393463
Belligerence 12.90 9.58 8 208711 146 50396259
Alice in wonderland syndrome 12.87 9.58 5 208714 30 50396375
Purple glove syndrome 12.82 9.58 9 208710 204 50396201
Panic reaction 12.76 9.58 38 208681 3531 50392874
Seizure like phenomena 12.68 9.58 18 208701 980 50395425
Gynaecomastia 12.67 9.58 8 208711 151 50396254
Gaze palsy 12.64 9.58 21 208698 1312 50395093
Gait deviation 12.58 9.58 6 208713 63 50396342
Abnormal uterine bleeding 12.56 9.58 20 208699 1206 50395199
Panniculitis 12.52 9.58 10 208709 8493 50387912
Serositis 12.51 9.58 14 208705 598 50395807
Death of relative 12.41 9.58 9 208710 215 50396190
Disinhibition 12.40 9.58 16 208703 794 50395611
Haemoglobin decreased 12.39 9.58 415 208304 126801 50269604
Pathogen resistance 12.39 9.58 4 208715 5685 50390720
Reduced facial expression 12.38 9.58 23 208696 1571 50394834
Delusional perception 12.38 9.58 9 208710 216 50396189
Product communication issue 12.36 9.58 11 208708 355 50396050
Subchorionic haemorrhage 12.35 9.58 8 208711 158 50396247
Trance 12.34 9.58 5 208714 34 50396371
CSF glucose decreased 12.33 9.58 6 208713 66 50396339
Blood parathyroid hormone decreased 12.31 9.58 7 208712 7107 50389298
Oral herpes 12.26 9.58 44 208675 20681 50375724
Negativism 12.25 9.58 11 208708 359 50396046
Exposure via breast milk 12.24 9.58 23 208696 1585 50394820
Neurological examination abnormal 12.16 9.58 9 208710 222 50396183
Overweight 12.14 9.58 34 208685 3052 50393353
Proteinuria 12.12 9.58 32 208687 16565 50379840
Communication disorder 12.11 9.58 28 208691 2233 50394172
Altered state of consciousness 12.10 9.58 141 208578 21769 50374636
Large intestine polyp 12.05 9.58 61 208658 7271 50389134
Reflexes abnormal 12.02 9.58 13 208706 534 50395871
Temporomandibular joint syndrome 12.01 9.58 37 208682 3502 50392903
Nausea 11.94 9.58 3175 205544 702223 49694182
Hyperthermia 11.93 9.58 63 208656 7633 50388772
Ulcer 11.88 9.58 43 208676 20157 50376248
Atrial fibrillation 11.86 9.58 324 208395 101421 50294984
Attention deficit hyperactivity disorder 11.84 9.58 29 208690 2400 50394005
Unintended pregnancy 11.81 9.58 46 208673 4900 50391505
Eosinophilic pneumonia 11.80 9.58 25 208694 1879 50394526
Glomerulonephritis minimal lesion 11.79 9.58 9 208710 233 50396172
Right ventricular dilatation 11.79 9.58 17 208702 939 50395466
Ear infection 11.77 9.58 61 208658 25909 50370496
Presyncope 11.75 9.58 152 208567 24046 50372359
Trichotillomania 11.72 9.58 7 208712 119 50396286
Head injury 11.72 9.58 151 208568 23869 50372536
Dyspnoea exertional 11.71 9.58 145 208574 51088 50345317
Blood pressure fluctuation 11.71 9.58 93 208626 35730 50360675
Metastases to liver 11.69 9.58 43 208676 20061 50376344
Pseudomonas infection 11.65 9.58 13 208706 9417 50386988
Hypoosmolar state 11.64 9.58 8 208711 175 50396230
Anticholinergic syndrome 11.63 9.58 24 208695 1771 50394634
Staphylococcal scalded skin syndrome 11.62 9.58 7 208712 121 50396284
Tendonitis 11.61 9.58 33 208686 16672 50379733
Serum serotonin decreased 11.61 9.58 4 208715 16 50396389
Crime 11.61 9.58 4 208715 16 50396389
Granulocytopenia neonatal 11.61 9.58 4 208715 16 50396389
Interstitial lung disease 11.60 9.58 152 208567 53024 50343381
Amnestic disorder 11.60 9.58 10 208709 309 50396096
Menopause 11.58 9.58 28 208691 2299 50394106
Blood prolactin decreased 11.55 9.58 5 208714 41 50396364
Meconium in amniotic fluid 11.53 9.58 9 208710 241 50396164
Heat exhaustion 11.53 9.58 6 208713 77 50396328
Narcotic bowel syndrome 11.52 9.58 7 208712 123 50396282
Adverse event 11.52 9.58 120 208599 43643 50352762
Aplastic anaemia 11.42 9.58 9 208710 7694 50388711
Boredom 11.42 9.58 3 208716 3 50396402
Postmortem blood drug level increased 11.36 9.58 13 208706 569 50395836
Heart rate decreased 11.36 9.58 96 208623 36401 50360004
Merycism 11.33 9.58 8 208711 183 50396222
Autoimmune myositis 11.32 9.58 6 208713 80 50396325
Antidepressant discontinuation syndrome 11.24 9.58 4 208715 18 50396387
Obsessive-compulsive personality disorder 11.24 9.58 4 208715 18 50396387
Shared psychotic disorder 11.24 9.58 4 208715 18 50396387
Febrile bone marrow aplasia 11.23 9.58 6 208713 6305 50390100
Breast discomfort 11.22 9.58 11 208708 402 50396003
Skin reaction 11.22 9.58 19 208700 11549 50384856
Congenital hydronephrosis 11.20 9.58 11 208708 403 50396002
Bursitis 11.20 9.58 50 208669 22085 50374320
Myelodysplastic syndrome 11.19 9.58 29 208690 15103 50381302
Polymenorrhagia 11.15 9.58 5 208714 45 50396360
Orgasm abnormal 11.13 9.58 6 208713 83 50396322
Dyspraxia 11.13 9.58 9 208710 254 50396151
Ankylosing spondylitis 11.10 9.58 8 208711 7157 50389248
Coma scale abnormal 11.09 9.58 44 208675 4727 50391678
Disseminated intravascular coagulation 11.08 9.58 35 208684 17100 50379305
Drug-device interaction 11.07 9.58 6 208713 84 50396321
Therapeutic response decreased 11.05 9.58 133 208586 47098 50349307
Cholelithiasis 11.05 9.58 219 208500 37754 50358651
Enuresis 11.01 9.58 26 208693 2103 50394302
Fluid retention 10.97 9.58 145 208574 50504 50345901
Genital hypoaesthesia 10.96 9.58 3 208716 4 50396401
Gastrostomy tube site complication 10.96 9.58 3 208716 4 50396401
Adverse drug reaction 10.92 9.58 161 208558 55061 50341344
Dependence 10.91 9.58 24 208695 1851 50394554
Chronic kidney disease 10.90 9.58 108 208611 39663 50356742
Hypotonia 10.89 9.58 64 208655 8070 50388335
Faeces discoloured 10.88 9.58 108 208611 16016 50380389
Phalangeal agenesis 10.87 9.58 5 208714 48 50396357
Stupor 10.83 9.58 36 208683 3547 50392858
Ventricular septal defect 10.82 9.58 39 208680 4002 50392403
Feeling of despair 10.82 9.58 25 208694 1993 50394412
Hyperuricaemia 10.72 9.58 3 208716 4677 50391728
Lactate pyruvate ratio increased 10.71 9.58 6 208713 90 50396315
Metastases to lymph nodes 10.68 9.58 8 208711 7016 50389389
Pelvic inflammatory disease 10.64 9.58 21 208698 1501 50394904
Tubulointerstitial nephritis 10.61 9.58 30 208689 15181 50381224
Tumour lysis syndrome 10.59 9.58 9 208710 7412 50388993
Hostility 10.59 9.58 23 208696 1759 50394646
Coprolalia 10.58 9.58 4 208715 22 50396383
Suspected suicide 10.57 9.58 47 208672 5310 50391095
Fear of injection 10.57 9.58 6 208713 6097 50390308
Cytokine release syndrome 10.56 9.58 12 208707 8622 50387783
Gamma-glutamyltransferase abnormal 10.52 9.58 8 208711 206 50396199
Muscle contractions involuntary 10.51 9.58 24 208695 1898 50394507
Labour complication 10.48 9.58 6 208713 94 50396311
Breast enlargement 10.47 9.58 20 208699 1395 50395010
Deprescribing error 10.44 9.58 4 208715 23 50396382
Sciatica 10.40 9.58 49 208670 21333 50375072
Paralysis recurrent laryngeal nerve 10.36 9.58 5 208714 54 50396351
Second primary malignancy 10.35 9.58 8 208711 6906 50389499
Genital rash 10.33 9.58 11 208708 444 50395961
Pulmonary toxicity 10.32 9.58 5 208714 5557 50390848
Aphasia 10.29 9.58 170 208549 28324 50368081
Pancreatic enzymes decreased 10.21 9.58 3 208716 6 50396399
Bladder cyst 10.21 9.58 3 208716 6 50396399
Cardio-respiratory distress 10.19 9.58 7 208712 153 50396252
Exposure via ingestion 10.17 9.58 30 208689 2773 50393632
Fungal infection 10.16 9.58 77 208642 29888 50366517
Mesenteric panniculitis 10.15 9.58 6 208713 100 50396305
Implant site irritation 10.15 9.58 7 208712 154 50396251
Cardiac septal defect 10.15 9.58 9 208710 289 50396116
Infantile haemangioma 10.12 9.58 5 208714 57 50396348
Renal failure 10.12 9.58 349 208370 106284 50290121
Neonatal disorder 10.05 9.58 12 208707 550 50395855
Blood citric acid increased 9.97 9.58 5 208714 59 50396346
Oral candidiasis 9.95 9.58 36 208683 16879 50379526
Death neonatal 9.95 9.58 8 208711 224 50396181
Hospitalisation 9.94 9.58 209 208510 67728 50328677
Dissociative amnesia 9.90 9.58 4 208715 27 50396378
Urticaria 9.90 9.58 435 208284 129126 50267279
Cytopenia 9.88 9.58 13 208706 8762 50387643
Psychotic behaviour 9.86 9.58 12 208707 561 50395844
Polydipsia psychogenic 9.83 9.58 5 208714 61 50396344
Dependent personality disorder 9.83 9.58 5 208714 61 50396344
Anal incontinence 9.81 9.58 81 208638 11409 50384996
Femur fracture 9.75 9.58 103 208616 37361 50359044
Aphthous ulcer 9.74 9.58 18 208701 10579 50385826
Rash maculo-papular 9.74 9.58 67 208652 26574 50369831
Blood test abnormal 9.73 9.58 20 208699 11299 50385106
Cellulitis 9.73 9.58 220 208499 70578 50325827
Polyarthritis 9.71 9.58 11 208708 7916 50388489
Granuloma skin 9.68 9.58 6 208713 5812 50390593
Hypertonia neonatal 9.59 9.58 8 208711 236 50396169
Impaired driving ability 9.59 9.58 37 208682 3924 50392481

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Depression 763.64 10.27 1197 102962 83950 29386418
Serotonin syndrome 677.07 10.27 532 103627 16980 29453388
Suicidal ideation 521.48 10.27 627 103532 34089 29436279
Drug interaction 493.40 10.27 1670 102489 195715 29274653
Intentional self-injury 410.69 10.27 345 103814 12116 29458252
Suicide attempt 290.50 10.27 469 103690 33641 29436727
Intentional overdose 287.13 10.27 499 103660 38029 29432339
Completed suicide 277.17 10.27 821 103338 89425 29380943
Anxiety 261.55 10.27 776 103383 84589 29385779
Drug abuse 221.16 10.27 701 103458 79182 29391186
Agitation 196.26 10.27 506 103653 50798 29419570
Tremor 185.23 10.27 625 103534 72913 29397455
Foetal exposure during pregnancy 174.15 10.27 375 103784 33492 29436876
Pyrexia 171.39 10.27 486 103673 287136 29183232
Aggression 169.70 10.27 382 103777 35159 29435209
Irritability 167.68 10.27 289 103870 21863 29448505
Agitation neonatal 154.04 10.27 75 104084 981 29469387
Somnolence 142.72 10.27 682 103477 93273 29377095
Maternal exposure during pregnancy 141.70 10.27 117 104042 4006 29466362
Atrial septal defect 127.88 10.27 138 104021 6651 29463717
Priapism 125.12 10.27 113 104046 4375 29465993
Respiratory disorder neonatal 122.15 10.27 71 104088 1354 29469014
Overdose 121.62 10.27 580 103579 79239 29391129
Paranoia 120.55 10.27 161 103998 9716 29460652
Dyskinesia 114.62 10.27 232 103927 19829 29450539
Acute kidney injury 113.38 10.27 515 103644 264752 29205616
Parkinsonism 111.67 10.27 133 104026 7145 29463223
Toxicity to various agents 111.03 10.27 1014 103145 172647 29297721
Sopor 110.77 10.27 163 103996 10771 29459597
Febrile neutropenia 109.26 10.27 141 104018 112099 29358269
Confusional state 106.58 10.27 793 103366 127084 29343284
Drug withdrawal syndrome neonatal 105.68 10.27 91 104068 3304 29467064
Obsessive-compulsive disorder 104.21 10.27 103 104056 4473 29465895
Pneumonia 98.65 10.27 692 103467 319480 29150888
Sexual dysfunction 97.13 10.27 111 104048 5703 29464665
Anger 97.11 10.27 153 104006 10737 29459631
Hallucination, auditory 95.72 10.27 142 104017 9451 29460917
Blepharospasm 94.26 10.27 54 104105 1001 29469367
Erectile dysfunction 92.06 10.27 199 103960 17810 29452558
Withdrawal syndrome 91.94 10.27 150 104009 10842 29459526
Delusion 91.04 10.27 151 104008 11065 29459303
Drug withdrawal syndrome 88.83 10.27 196 103963 17788 29452580
Extrapyramidal disorder 88.16 10.27 146 104013 10685 29459683
Akathisia 87.07 10.27 113 104046 6629 29463739
Exposure during pregnancy 85.90 10.27 127 104032 8427 29461941
Loss of libido 84.90 10.27 68 104091 2228 29468140
Malignant neoplasm progression 84.78 10.27 81 104078 73778 29396590
Loss of personal independence in daily activities 84.22 10.27 238 103921 25202 29445166
Off label use 84.08 10.27 668 103491 300132 29170236
Restlessness 83.14 10.27 217 103942 21928 29448440
Psychotic disorder 81.12 10.27 204 103955 20150 29450218
Anaemia 81.10 10.27 398 103761 200553 29269815
Sepsis 80.40 10.27 247 103912 142435 29327933
Dystonia 78.79 10.27 131 104028 9618 29460750
Insomnia 78.79 10.27 559 103600 88202 29382166
Pancytopenia 76.33 10.27 109 104050 83059 29387309
Catatonia 75.82 10.27 86 104073 4382 29465986
Homicidal ideation 75.22 10.27 66 104093 2458 29467910
Renal impairment 74.24 10.27 107 104052 81226 29389142
Thrombocytopenia 74.11 10.27 236 103923 134587 29335781
Mania 73.51 10.27 119 104040 8544 29461824
Hallucination 73.25 10.27 332 103827 44380 29425988
Intrusive thoughts 72.67 10.27 29 104130 226 29470142
Derealisation 72.29 10.27 37 104122 542 29469826
Tachyphrenia 69.15 10.27 46 104113 1123 29469245
Hypomania 69.12 10.27 59 104100 2116 29468252
Neutropenia 68.64 10.27 236 103923 131475 29338893
Abnormal behaviour 67.60 10.27 207 103952 22920 29447448
Obsessive thoughts 66.97 10.27 36 104123 586 29469782
Sedation 65.79 10.27 171 103988 17234 29453134
Mood swings 63.44 10.27 101 104058 7150 29463218
Neuroleptic malignant syndrome 62.42 10.27 160 103999 15988 29454380
Hypertonia neonatal 60.13 10.27 29 104130 371 29469997
Feeling jittery 60.08 10.27 69 104090 3564 29466804
Bradykinesia 59.60 10.27 67 104092 3380 29466988
Major depression 58.69 10.27 70 104089 3765 29466603
Amnesia 58.28 10.27 194 103965 22449 29447919
Bradyphrenia 56.56 10.27 72 104087 4142 29466226
Colitis microscopic 56.39 10.27 48 104111 1715 29468653
Cytomegalovirus infection 55.19 10.27 8 104151 23207 29447161
Nightmare 53.65 10.27 122 104037 11295 29459073
Treatment noncompliance 53.22 10.27 197 103962 24030 29446338
Rash 53.13 10.27 421 103738 189398 29280970
Hyperhidrosis 52.95 10.27 399 103760 64141 29406227
Large for dates baby 52.70 10.27 35 104124 852 29469516
Patent ductus arteriosus 52.68 10.27 60 104099 3071 29467297
Interstitial lung disease 52.58 10.27 76 104083 57642 29412726
Septic shock 52.57 10.27 87 104072 62473 29407895
Neuropathy peripheral 52.38 10.27 107 104052 70920 29399448
Disturbance in attention 52.01 10.27 180 103979 21244 29449124
Disease progression 51.86 10.27 134 104025 81782 29388586
Hallucination, visual 51.18 10.27 142 104017 14873 29455495
Pleural effusion 50.79 10.27 111 104048 71797 29398571
Fall 50.71 10.27 891 103268 176287 29294081
Genital hypoaesthesia 49.82 10.27 21 104138 191 29470177
Neonatal respiratory distress syndrome 49.42 10.27 64 104095 3746 29466622
Seizure 49.22 10.27 523 103636 92600 29377768
Homicide 48.90 10.27 34 104125 894 29469474
Social avoidant behaviour 48.86 10.27 56 104103 2886 29467482
Tic 48.80 10.27 45 104114 1790 29468578
Apathy 48.64 10.27 82 104077 6089 29464279
Bruxism 48.30 10.27 42 104117 1545 29468823
Thinking abnormal 47.28 10.27 74 104085 5162 29465206
General physical health deterioration 46.62 10.27 195 103964 102662 29367706
Maternal exposure during breast feeding 46.59 10.27 40 104119 1446 29468922
Dyspnoea 45.86 10.27 843 103316 325889 29144479
Blood prolactin increased 45.49 10.27 40 104119 1494 29468874
Infusion related reaction 44.89 10.27 53 104106 43833 29426535
Cogwheel rigidity 44.23 10.27 36 104123 1207 29469161
Cardiac failure 44.07 10.27 138 104021 79149 29391219
Ventricular septal defect 43.78 10.27 58 104101 3471 29466897
Restless legs syndrome 43.78 10.27 84 104075 6900 29463468
Haemangioma congenital 43.14 10.27 25 104134 474 29469894
Oromandibular dystonia 41.74 10.27 24 104135 448 29469920
Depressed mood 41.50 10.27 140 104019 16308 29454060
Panic attack 41.40 10.27 91 104068 8235 29462133
Hyponatraemia 41.09 10.27 391 103768 67242 29403126
Antidepressant drug level increased 40.78 10.27 15 104144 91 29470277
Resting tremor 40.71 10.27 26 104133 591 29469777
Bone marrow failure 40.68 10.27 23 104136 27426 29442942
Sleep disorder 40.61 10.27 182 103977 24204 29446164
Platelet count decreased 40.59 10.27 210 103949 104462 29365906
Renal failure 40.03 10.27 249 103910 118350 29352018
Psychomotor hyperactivity 39.97 10.27 89 104070 8124 29462244
Feeling abnormal 39.92 10.27 328 103831 54117 29416251
Product substitution issue 39.80 10.27 95 104064 9077 29461291
Hyperkalaemia 39.17 10.27 100 104059 61292 29409076
Bipolar disorder 39.11 10.27 53 104106 3242 29467126
Muscle twitching 39.09 10.27 87 104072 7939 29462429
Anorgasmia 38.62 10.27 25 104134 582 29469786
Oesophageal pain 38.15 10.27 27 104132 731 29469637
Libido decreased 37.78 10.27 60 104099 4238 29466130
Ascites 37.69 10.27 44 104115 36575 29433793
Apgar score low 37.33 10.27 28 104131 831 29469537
Pneumocystis jirovecii pneumonia 37.18 10.27 7 104152 16772 29453596
Speech disorder 35.83 10.27 171 103988 23345 29447023
Arthralgia 35.70 10.27 317 103842 139300 29331068
Ejaculation failure 35.58 10.27 26 104133 741 29469627
Antipsychotic drug level increased 35.26 10.27 50 104109 3193 29467175
Muscle rigidity 35.09 10.27 92 104067 9319 29461049
Foaming at mouth 34.97 10.27 25 104134 688 29469680
Diarrhoea 34.90 10.27 899 103260 331799 29138569
Premature ejaculation 34.77 10.27 14 104145 112 29470256
Morose 34.68 10.27 8 104151 3 29470365
Pressure of speech 34.51 10.27 21 104138 437 29469931
Hepatic function abnormal 34.48 10.27 53 104106 39206 29431162
Erythema 34.45 10.27 143 104016 75463 29394905
Infantile apnoea 34.41 10.27 27 104132 858 29469510
Small for dates baby 34.30 10.27 52 104107 3527 29466841
Anhedonia 33.90 10.27 77 104082 7123 29463245
Ideas of reference 33.83 10.27 11 104148 43 29470325
Mucosal inflammation 33.56 10.27 37 104122 31558 29438810
Dysphoria 33.36 10.27 39 104120 2053 29468315
Semen discolouration 33.10 10.27 9 104150 15 29470353
Loss of consciousness 32.83 10.27 402 103757 73654 29396714
Stomatitis 32.69 10.27 50 104109 37063 29433305
Persecutory delusion 32.63 10.27 39 104120 2102 29468266
Blood creatine phosphokinase increased 32.60 10.27 250 103909 40394 29429974
Middle insomnia 32.57 10.27 66 104093 5642 29464726
Depersonalisation/derealisation disorder 32.30 10.27 22 104137 559 29469809
Affective disorder 32.23 10.27 47 104112 3079 29467289
Parkinsonism hyperpyrexia syndrome 32.19 10.27 12 104147 76 29470292
Schizophrenia 31.79 10.27 71 104088 6494 29463874
Male sexual dysfunction 31.77 10.27 16 104143 226 29470142
Rheumatoid arthritis 31.64 10.27 40 104119 32112 29438256
Persistent depressive disorder 31.50 10.27 17 104142 279 29470089
Acute psychosis 31.26 10.27 34 104125 1653 29468715
Delusion of replacement 31.06 10.27 13 104146 116 29470252
Meconium aspiration syndrome 30.97 10.27 10 104149 38 29470330
Bradycardia neonatal 30.90 10.27 26 104133 914 29469454
C-reactive protein increased 30.69 10.27 69 104090 44194 29426174
Blood creatinine increased 30.64 10.27 175 103984 84927 29385441
Dissociation 30.63 10.27 28 104131 1101 29469267
Death 30.60 10.27 945 103214 341139 29129229
Personality change 30.58 10.27 57 104102 4581 29465787
Tremor neonatal 30.57 10.27 18 104141 352 29470016
Tumour lysis syndrome 30.32 10.27 6 104153 13878 29456490
Electrocardiogram QT prolonged 29.95 10.27 224 103935 35913 29434455
Nasopharyngitis 29.64 10.27 109 104050 59556 29410812
Drug reaction with eosinophilia and systemic symptoms 29.49 10.27 33 104126 27959 29442409
Torticollis 29.40 10.27 27 104132 1068 29469300
Drug screen positive 29.28 10.27 50 104109 3751 29466617
Muscle strain 29.25 10.27 48 104111 3485 29466883
White blood cell count decreased 29.16 10.27 173 103986 83189 29387179
Generalised tonic-clonic seizure 29.03 10.27 139 104020 19000 29451368
Tearfulness 28.63 10.27 32 104127 1604 29468764
Hyporesponsive to stimuli 28.60 10.27 25 104134 926 29469442
Mental disorder 28.39 10.27 105 104054 12800 29457568
Myoclonus 28.21 10.27 107 104052 13202 29457166
Dementia with Lewy bodies 28.18 10.27 21 104138 617 29469751
Platelet aggregation abnormal 28.16 10.27 8 104151 17 29470351
Head discomfort 28.14 10.27 45 104114 3197 29467171
Lymphadenopathy 28.10 10.27 28 104131 25021 29445347
Overweight 28.09 10.27 30 104129 1428 29468940
Drug dependence 28.03 10.27 147 104012 20834 29449534
Neonatal respiratory acidosis 28.00 10.27 10 104149 55 29470313
Left ventricular false tendon 27.91 10.27 6 104153 0 29470368
Neonatal behavioural syndrome 27.83 10.27 12 104147 116 29470252
Negativism 27.76 10.27 17 104142 358 29470010
Prescribed overdose 27.53 10.27 80 104079 8603 29461765
Grandiosity 27.48 10.27 16 104143 306 29470062
Exposure via breast milk 27.44 10.27 32 104127 1680 29468688
Alcoholism 27.42 10.27 40 104119 2621 29467747
Gastrointestinal motility disorder 27.41 10.27 36 104123 2136 29468232
Bipolar I disorder 27.41 10.27 22 104137 723 29469645
Urticaria 27.05 10.27 100 104059 54560 29415808
Basal cell carcinoma 26.78 10.27 13 104146 16897 29453471
Tardive dyskinesia 26.74 10.27 58 104101 5200 29465168
Neonatal respiratory arrest 26.72 10.27 8 104151 22 29470346
Persistent foetal circulation 26.55 10.27 16 104143 327 29470041
Agitated depression 26.48 10.27 14 104145 220 29470148
Pneumonitis 26.45 10.27 36 104123 28008 29442360
Suicidal behaviour 26.15 10.27 28 104131 1337 29469031
Prostate cancer 25.91 10.27 31 104128 25496 29444872
Maternal drugs affecting foetus 25.86 10.27 48 104111 3845 29466523
Dystonic tremor 25.79 10.27 13 104146 184 29470184
Impulsive behaviour 25.76 10.27 33 104126 1910 29468458
Phospholipidosis 25.58 10.27 9 104150 47 29470321
Anorectal discomfort 25.52 10.27 30 104129 1589 29468779
Generalised anxiety disorder 25.34 10.27 20 104139 641 29469727
Oedema peripheral 25.20 10.27 238 103921 103319 29367049
Self esteem decreased 25.06 10.27 18 104141 499 29469869
Neonatal respiratory distress 25.03 10.27 18 104141 500 29469868
Trismus 24.93 10.27 36 104123 2337 29468031
Myelodysplastic syndrome 24.84 10.27 16 104143 17778 29452590
Leukopenia 24.77 10.27 105 104054 55098 29415270
Mydriasis 24.25 10.27 61 104098 6024 29464344
Macrophages increased 24.24 10.27 12 104147 163 29470205
Depressive symptom 24.10 10.27 30 104129 1687 29468681
Neutrophil count decreased 24.07 10.27 76 104083 43491 29426877
Orthostatic hypotension 23.95 10.27 149 104010 22480 29447888
Haemoglobin decreased 23.91 10.27 255 103904 108120 29362248
Radiologically isolated syndrome 23.78 10.27 6 104153 6 29470362
Unmasking of previously unidentified disease 23.77 10.27 20 104139 703 29469665
Multiple organ dysfunction syndrome 23.68 10.27 128 104031 62988 29407380
Graft versus host disease 23.64 10.27 3 104156 9625 29460743
Balance disorder 23.41 10.27 212 103947 35958 29434410
Disorientation 23.36 10.27 181 103978 29334 29441034
Myelosuppression 23.35 10.27 7 104152 12220 29458148
Neonatal anoxia 23.26 10.27 5 104154 0 29470368
Drug resistance 23.12 10.27 25 104134 21515 29448853
Maternal exposure timing unspecified 22.81 10.27 15 104144 359 29470009
Newborn persistent pulmonary hypertension 22.72 10.27 10 104149 102 29470266
Inflammation 22.65 10.27 28 104131 22700 29447668
Urinary hesitation 22.42 10.27 33 104126 2180 29468188
Dermatillomania 22.25 10.27 8 104151 45 29470323
Treatment failure 22.17 10.27 62 104097 36877 29433491
Haemophagocytic lymphohistiocytosis 21.99 10.27 5 104154 10499 29459869
Negative thoughts 21.98 10.27 18 104141 609 29469759
Bronchopulmonary aspergillosis 21.94 10.27 8 104151 12336 29458032
Weight decrease neonatal 21.89 10.27 14 104145 319 29470049
Post concussion syndrome 21.83 10.27 10 104149 113 29470255
Prader-Willi syndrome 21.70 10.27 6 104153 11 29470357
Haemorrhagic hepatic cyst 21.70 10.27 6 104153 11 29470357
Inappropriate antidiuretic hormone secretion 21.63 10.27 86 104073 10846 29459522
Tongue biting 21.51 10.27 19 104140 714 29469654
Alcohol interaction 21.41 10.27 36 104123 2667 29467701
Excessive masturbation 21.34 10.27 9 104150 82 29470286
Hypotonia neonatal 21.28 10.27 24 104135 1215 29469153
Orgasm abnormal 21.08 10.27 10 104149 123 29470245
Reflux laryngitis 21.04 10.27 6 104153 13 29470355
Rapid eye movements sleep abnormal 20.97 10.27 11 104148 170 29470198
Attention deficit hyperactivity disorder 20.95 10.27 32 104127 2185 29468183
Pulmonary artery stenosis 20.92 10.27 12 104147 223 29470145
Cytokine release syndrome 20.91 10.27 10 104149 13109 29457259
Peripheral swelling 20.87 10.27 135 104024 63604 29406764
Cognitive disorder 20.81 10.27 148 104011 23351 29447017
Oesophageal ulcer haemorrhage 20.74 10.27 11 104148 174 29470194
Social anxiety disorder 20.73 10.27 12 104147 227 29470141
Sedation complication 20.61 10.27 24 104135 1258 29469110
Parasomnia 20.58 10.27 14 104145 355 29470013
Lung disorder 20.50 10.27 48 104111 30314 29440054
Atrial fibrillation 20.42 10.27 256 103903 105390 29364978
Hypertonia 20.35 10.27 43 104116 3786 29466582
Product complaint 20.31 10.27 53 104106 5352 29465016
Infection 20.15 10.27 173 103986 76578 29393790
Product use in unapproved indication 20.15 10.27 202 103957 86673 29383695
Acute respiratory distress syndrome 20.10 10.27 31 104128 22904 29447464
Hepatic enzyme increased 20.08 10.27 57 104102 33742 29436626
Transplant rejection 20.08 10.27 4 104155 9208 29461160
Hepatotoxicity 20.01 10.27 20 104139 17847 29452521
Muscle tightness 19.99 10.27 46 104113 4292 29466076
Male orgasmic disorder 19.86 10.27 9 104150 99 29470269
Tongue injury 19.86 10.27 9 104150 99 29470269
Implant site extravasation 19.81 10.27 14 104145 378 29469990
Chronic kidney disease 19.79 10.27 64 104095 36352 29434016
COVID-19 19.77 10.27 63 104096 35951 29434417
Cryptorchism 19.74 10.27 29 104130 1913 29468455
Mood altered 19.55 10.27 68 104091 8043 29462325
Cerebral haemorrhage neonatal 19.54 10.27 12 104147 254 29470114
Tubulointerstitial nephritis 19.47 10.27 20 104139 17623 29452745
Drug level increased 19.44 10.27 123 104036 18664 29451704
Periodic limb movement disorder 19.39 10.27 9 104150 105 29470263
Intentional product misuse 19.38 10.27 197 103962 34464 29435904
Schizophreniform disorder 19.35 10.27 8 104151 69 29470299
Blood cholesterol increased 19.29 10.27 107 104052 15488 29454880
Haemoptysis 19.29 10.27 50 104109 30500 29439868
Nervousness 19.29 10.27 85 104074 11221 29459147
Influenza 19.20 10.27 79 104080 41802 29428566
Sexual activity increased 19.19 10.27 6 104153 20 29470348
Psychiatric decompensation 19.09 10.27 25 104134 1479 29468889
Joint swelling 18.98 10.27 100 104059 49530 29420838
Respiratory failure 18.91 10.27 235 103924 96896 29373472
Violence-related symptom 18.71 10.27 15 104144 492 29469876
Crying 18.62 10.27 51 104108 5300 29465068
Abulia 18.61 10.27 15 104144 496 29469872
Aspergillus infection 18.57 10.27 7 104152 10574 29459794
Foetal growth restriction 18.54 10.27 41 104118 3725 29466643
Hypotension 18.52 10.27 532 103627 193822 29276546
Dysphemia 18.25 10.27 24 104135 1426 29468942
Disturbance in sexual arousal 18.20 10.27 9 104150 122 29470246
Cytopenia 18.19 10.27 6 104153 9853 29460515
High-pitched crying 18.15 10.27 5 104154 9 29470359
Blood bilirubin increased 18.11 10.27 60 104099 33833 29436535
Libido increased 17.86 10.27 17 104142 704 29469664
Synovitis 17.82 10.27 8 104151 10882 29459486
Euphoric mood 17.81 10.27 47 104112 4778 29465590
Lymphomatoid papulosis 17.81 10.27 10 104149 178 29470190
Gout 17.74 10.27 20 104139 16891 29453477
Cardiogenic shock 17.73 10.27 25 104134 19165 29451203
Congenital pulmonary valve atresia 17.71 10.27 7 104152 53 29470315
Libido disorder 17.70 10.27 11 104148 238 29470130
Confabulation 17.69 10.27 9 104150 130 29470238
Apallic syndrome 17.62 10.27 11 104148 240 29470128
Rash maculo-papular 17.55 10.27 37 104122 24252 29446116
Loose associations 17.49 10.27 7 104152 55 29470313
Action tremor 17.49 10.27 7 104152 55 29470313
Cerebral infarction 17.48 10.27 38 104121 24637 29445731
Memory impairment 17.48 10.27 201 103958 36269 29434099
Nephropathy toxic 17.45 10.27 8 104151 10748 29459620
Pruritus 17.40 10.27 298 103861 116551 29353817
Arthritis 17.34 10.27 39 104120 24980 29445388
Gastrointestinal haemorrhage 17.19 10.27 188 103971 79345 29391023
Therapeutic response unexpected 17.12 10.27 68 104091 8570 29461798
Ejaculation disorder 17.05 10.27 19 104140 949 29469419
Blood ethanol increased 17.01 10.27 14 104145 477 29469891
Grunting 16.98 10.27 12 104147 324 29470044
Pain in extremity 16.98 10.27 280 103879 110153 29360215
Hypersomnia 16.96 10.27 79 104080 10675 29459693
Dysarthria 16.95 10.27 175 103984 30736 29439632
Physical assault 16.94 10.27 20 104139 1064 29469304
Granulocytopenia 16.90 10.27 53 104106 5941 29464427
Coloboma 16.88 10.27 9 104150 144 29470224
Polyneuropathy 16.86 10.27 11 104148 12141 29458227
Acute myeloid leukaemia 16.82 10.27 20 104139 16493 29453875
Alcohol poisoning 16.78 10.27 35 104124 3054 29467314
Obesity 16.71 10.27 74 104085 9789 29460579
Alveolar bone resorption 16.64 10.27 5 104154 14 29470354
Thrombotic microangiopathy 16.52 10.27 5 104154 8676 29461692
Blood triglycerides increased 16.51 10.27 89 104070 12745 29457623
Hypoglycaemia neonatal 16.45 10.27 25 104134 1699 29468669
Septum pellucidum agenesis 16.39 10.27 7 104152 66 29470302
Neonatal disorder 16.32 10.27 17 104142 786 29469582
Acute myocardial infarction 16.16 10.27 102 104057 48336 29422032
Duplicate therapy error 16.14 10.27 8 104151 109 29470259
Tongue spasm 16.09 10.27 6 104153 38 29470330
Cellulitis 16.09 10.27 95 104064 45745 29424623
Metabolic acidosis 16.06 10.27 73 104086 37589 29432779
Impaired work ability 16.03 10.27 50 104109 5590 29464778
Urinary incontinence 15.89 10.27 106 104053 16375 29453993
Respiratory dyskinesia 15.70 10.27 5 104154 18 29470350
Ejaculation delayed 15.67 10.27 10 104149 227 29470141
Compulsive sexual behaviour 15.63 10.27 10 104149 228 29470140
Transient tachypnoea of the newborn 15.61 10.27 9 104150 169 29470199
Posture abnormal 15.51 10.27 26 104133 1921 29468447
Intentional product use issue 15.49 10.27 87 104072 42411 29427957
Weight increased 15.38 10.27 366 103793 76301 29394067
Hepatic failure 15.36 10.27 58 104101 31454 29438914
Kidney transplant rejection 15.35 10.27 3 104156 7002 29463366
Psychomotor retardation 15.33 10.27 33 104126 2943 29467425
Paraneoplastic rash 15.21 10.27 7 104152 80 29470288
Intraventricular haemorrhage neonatal 15.18 10.27 10 104149 240 29470128
Malpositioned teeth 15.09 10.27 5 104154 21 29470347
Pneumonia bacterial 15.07 10.27 7 104152 9336 29461032
Hyperuricaemia 14.99 10.27 3 104156 6886 29463482
Obsessive rumination 14.97 10.27 4 104155 6 29470362
Drug screen false positive 14.92 10.27 15 104144 665 29469703
Palmar-plantar erythrodysaesthesia syndrome 14.90 10.27 18 104141 14741 29455627
Hypersexuality 14.88 10.27 21 104138 1335 29469033
Temperature regulation disorder 14.87 10.27 14 104145 572 29469796
Gastrooesophageal reflux disease 14.83 10.27 173 103986 31323 29439045
Dissociative identity disorder 14.73 10.27 5 104154 23 29470345
Cardiac failure acute 14.66 10.27 7 104152 9185 29461183
Red blood cell elliptocytes present 14.62 10.27 7 104152 88 29470280
Gangrene neonatal 14.59 10.27 9 104150 192 29470176
Feelings of worthlessness 14.58 10.27 10 104149 257 29470111
Drug intolerance 14.58 10.27 105 104054 48274 29422094
Obsessive-compulsive symptom 14.55 10.27 7 104152 89 29470279
Illusion 14.52 10.27 15 104144 687 29469681
Hypocalcaemia 14.49 10.27 32 104127 20633 29449735
Activation syndrome 14.35 10.27 7 104152 92 29470276
Emotional disorder 14.27 10.27 44 104115 4887 29465481
Pulmonary microemboli 14.24 10.27 4 104155 8 29470360
Substance use disorder 14.22 10.27 10 104149 268 29470100
Congenital hearing disorder 14.15 10.27 7 104152 95 29470273
Hippocampal sclerosis 14.15 10.27 7 104152 95 29470273
Anuria 14.12 10.27 8 104151 9533 29460835
Strabismus congenital 14.08 10.27 5 104154 27 29470341
Peritonitis 14.01 10.27 19 104140 14805 29455563
Bladder dilatation 13.97 10.27 20 104139 1288 29469080
Constricted affect 13.96 10.27 3 104156 0 29470368
Enteric neuropathy 13.96 10.27 3 104156 0 29470368
Arterial ligation 13.96 10.27 3 104156 0 29470368
Foetal damage 13.96 10.27 3 104156 0 29470368
Nasal cavity packing 13.96 10.27 3 104156 0 29470368
Eczema 13.81 10.27 17 104142 13809 29456559
Painful erection 13.81 10.27 9 104150 212 29470156
Rebound psychosis 13.79 10.27 8 104151 152 29470216
Poor feeding infant 13.79 10.27 12 104147 442 29469926
Maculopathy 13.77 10.27 16 104143 837 29469531
Wrong patient received product 13.76 10.27 27 104132 2255 29468113
Hallucinations, mixed 13.73 10.27 28 104131 2405 29467963
Muscle contractions involuntary 13.68 10.27 23 104136 1704 29468664
Colitis 13.67 10.27 60 104099 31188 29439180
Abdominal distension 13.66 10.27 100 104059 45811 29424557
Transposition of the great vessels 13.65 10.27 12 104147 448 29469920
Genital anaesthesia 13.63 10.27 4 104155 10 29470358
Self-medication 13.61 10.27 26 104133 2128 29468240
Liver disorder 13.57 10.27 51 104108 27698 29442670
Drug hypersensitivity 13.55 10.27 326 103833 68080 29402288
Fungal infection 13.49 10.27 17 104142 13668 29456700
Emotional poverty 13.45 10.27 12 104147 457 29469911
Hypoalbuminaemia 13.41 10.27 10 104149 10295 29460073
Cataract congenital 13.40 10.27 6 104153 64 29470304
Drug eruption 13.40 10.27 24 104135 16717 29453651
Post-traumatic stress disorder 13.38 10.27 22 104137 1600 29468768
Dysgraphia 13.38 10.27 25 104134 2013 29468355
Sneezing 13.35 10.27 40 104119 4374 29465994
Illness anxiety disorder 13.30 10.27 8 104151 163 29470205
Somnambulism 13.26 10.27 30 104129 2768 29467600
Cytomegalovirus viraemia 13.25 10.27 3 104156 6317 29464051
Hepatocellular injury 13.24 10.27 35 104124 21208 29449160
Pathogen resistance 13.22 10.27 6 104153 8110 29462258
Onychomycosis 13.17 10.27 25 104134 2037 29468331
Neutrophil count increased 13.14 10.27 93 104066 14649 29455719
Optic ischaemic neuropathy 13.11 10.27 24 104135 1902 29468466
Poverty of thought content 13.11 10.27 5 104154 34 29470334
Skin indentation 13.11 10.27 4 104155 12 29470356
Contraindicated product administered 13.05 10.27 28 104131 18238 29452130
Delirium 13.02 10.27 203 103956 39194 29431174
Vascular dementia 12.98 10.27 12 104147 479 29469889
Feeling drunk 12.96 10.27 22 104137 1642 29468726
Hyperprolactinaemia 12.96 10.27 19 104140 1251 29469117
Selective mutism 12.93 10.27 6 104153 70 29470298
Blood urea increased 12.90 10.27 53 104106 28059 29442309
Transaminases increased 12.89 10.27 39 104120 22623 29447745
Device related infection 12.89 10.27 22 104137 15614 29454754
Salivary hypersecretion 12.86 10.27 56 104103 7353 29463015
Cardiac failure congestive 12.83 10.27 191 103968 76390 29393978
Psychotic symptom 12.79 10.27 20 104139 1394 29468974
Pulmonary embolism 12.78 10.27 191 103968 76343 29394025
Brugada syndrome 12.76 10.27 14 104145 687 29469681
Self-injurious ideation 12.74 10.27 21 104138 1530 29468838
Stoma site infection 12.73 10.27 14 104145 689 29469679
Suspected suicide 12.70 10.27 37 104122 3983 29466385
COVID-19 pneumonia 12.70 10.27 9 104150 9513 29460855
Sinusitis 12.69 10.27 70 104089 34280 29436088
Deep vein thrombosis 12.67 10.27 135 104024 57264 29413104
Diffuse vasculitis 12.63 10.27 6 104153 74 29470294
Gaze palsy 12.63 10.27 19 104140 1280 29469088
Abnormal dreams 12.55 10.27 53 104106 6867 29463501
Decreased interest 12.53 10.27 25 104134 2113 29468255
Skin turgor decreased 12.53 10.27 11 104148 410 29469958
Second primary malignancy 12.51 10.27 4 104155 6701 29463667
Fallot's tetralogy 12.48 10.27 8 104151 183 29470185
Depression suicidal 12.45 10.27 19 104140 1296 29469072
Pregnancy 12.45 10.27 9 104150 252 29470116
Body mass index increased 12.43 10.27 15 104144 817 29469551
Enterocolitis 12.40 10.27 4 104155 6662 29463706
Urinary retention 12.37 10.27 169 103990 31729 29438639
Drug dose titration not performed 12.36 10.27 9 104150 255 29470113
Immune reconstitution inflammatory syndrome 12.35 10.27 6 104153 7796 29462572
Proteinuria 12.34 10.27 23 104136 15781 29454587
Umbilical cord abnormality 12.31 10.27 5 104154 41 29470327
Sleep inertia 12.23 10.27 4 104155 16 29470352
Blood pressure fluctuation 12.23 10.27 33 104126 19861 29450507
Alanine aminotransferase increased 12.21 10.27 176 103983 70768 29399600
Respiratory arrest 12.21 10.27 142 104017 25691 29444677
Gun shot wound 12.20 10.27 17 104142 1068 29469300
Hepatorenal failure 12.18 10.27 12 104147 519 29469849
Schizoaffective disorder 12.11 10.27 17 104142 1075 29469293
Labelled drug-drug interaction medication error 12.09 10.27 15 104144 12144 29458224
Premature baby 12.06 10.27 103 104056 17177 29453191
Osteonecrosis of jaw 12.05 10.27 25 104134 16485 29453883
Squamous cell carcinoma 12.03 10.27 11 104148 10240 29460128
Electrocardiogram QT interval abnormal 12.03 10.27 6 104153 83 29470285
Anaphylactic reaction 12.03 10.27 53 104106 27520 29442848
Cough 12.02 10.27 347 103812 126380 29343988
Skin infection 12.00 10.27 4 104155 6523 29463845
Tension 11.98 10.27 23 104136 1890 29468478
Moaning 11.98 10.27 14 104145 737 29469631
Mixed dementia 11.97 10.27 9 104150 268 29470100
Dehydration 11.97 10.27 310 103849 114438 29355930
End stage renal disease 11.97 10.27 6 104153 7658 29462710
Renal injury 11.91 10.27 11 104148 10191 29460177
Abdominoplasty 11.89 10.27 3 104156 3 29470365
Congenital gastric anomaly 11.89 10.27 3 104156 3 29470365
Colostomy infection 11.89 10.27 3 104156 3 29470365
Foetal death 11.86 10.27 8 104151 200 29470168
Bankruptcy 11.85 10.27 4 104155 18 29470350
Psoriatic arthropathy 11.81 10.27 21 104138 14670 29455698
Herpes zoster 11.80 10.27 60 104099 29992 29440376
Enuresis 11.78 10.27 24 104135 2060 29468308
Type 2 diabetes mellitus 11.71 10.27 85 104074 13496 29456872
Discouragement 11.70 10.27 7 104152 141 29470227
Velopharyngeal incompetence 11.68 10.27 4 104155 19 29470349
Platelet aggregation decreased 11.68 10.27 4 104155 19 29470349
Hepatitis 11.66 10.27 36 104123 20747 29449621
Disseminated intravascular coagulation 11.64 10.27 34 104125 19946 29450422
Drug tolerance increased 11.63 10.27 11 104148 452 29469916
Cholangitis 11.62 10.27 6 104153 7531 29462837
Flashback 11.53 10.27 7 104152 145 29470223
Facial discomfort 11.51 10.27 4 104155 20 29470348
Shock haemorrhagic 11.51 10.27 10 104149 9541 29460827
Food interaction 11.49 10.27 15 104144 885 29469483
Hypomagnesaemia 11.49 10.27 28 104131 17440 29452928
Oxygen saturation decreased 11.47 10.27 102 104057 44835 29425533
Stress 11.47 10.27 121 104038 21369 29448999
Mallory-Weiss syndrome 11.46 10.27 18 104141 1259 29469109
Delusional disorder, unspecified type 11.43 10.27 13 104146 664 29469704
Dyskinesia neonatal 11.43 10.27 3 104156 4 29470364
Butterfly rash 11.42 10.27 6 104153 93 29470275
Product use issue 11.35 10.27 121 104038 51323 29419045
Vesicoureteric reflux 11.32 10.27 7 104152 150 29470218
Pyromania 11.28 10.27 5 104154 52 29470316
Daydreaming 11.25 10.27 11 104148 471 29469897
Cleft palate 11.22 10.27 12 104147 572 29469796
Neonatal seizure 11.22 10.27 11 104148 473 29469895
Haemolytic anaemia 11.18 10.27 10 104149 9409 29460959
Loss of employment 11.16 10.27 11 104148 476 29469892
Morbid thoughts 11.13 10.27 8 104151 222 29470146
Yawning 11.10 10.27 11 104148 479 29469889
Dyspnoea exertional 11.09 10.27 79 104080 36411 29433957
Poverty of speech 11.07 10.27 8 104151 224 29470144
Panic reaction 11.07 10.27 18 104141 1297 29469071
Pseudocholinesterase deficiency 11.05 10.27 4 104155 23 29470345
Hypersensitivity 11.05 10.27 126 104033 52777 29417591
Serum ferritin increased 11.04 10.27 3 104156 5585 29464783
Pericardial effusion 11.02 10.27 38 104121 21170 29449198
Craniosynostosis 11.00 10.27 9 104150 304 29470064
Panic disorder 11.00 10.27 17 104142 1173 29469195
Localised infection 10.88 10.27 20 104139 13796 29456572
General symptom 10.88 10.27 14 104145 814 29469554
Dysaesthesia 10.87 10.27 23 104136 2027 29468341
Haematochezia 10.79 10.27 81 104078 36902 29433466
Neurotoxicity 10.77 10.27 22 104137 14591 29455777
Congenital skin dimples 10.70 10.27 7 104152 166 29470202
PCO2 abnormal 10.68 10.27 3 104156 6 29470362
Platelet disorder 10.67 10.27 18 104141 1337 29469031
Progressive multifocal leukoencephalopathy 10.66 10.27 9 104150 8710 29461658
Dementia 10.66 10.27 74 104085 11584 29458784
Epstein-Barr virus infection 10.64 10.27 5 104154 6624 29463744
Movement disorder 10.58 10.27 67 104092 10170 29460198
Hyperbilirubinaemia 10.58 10.27 23 104136 14911 29455457
Bronchospasm 10.48 10.27 11 104148 9598 29460770
Chorea 10.48 10.27 15 104144 966 29469402
Affect lability 10.45 10.27 31 104128 3371 29466997
Lactic acidosis 10.45 10.27 63 104096 30184 29440184
Diverticulitis 10.41 10.27 30 104129 17674 29452694
Partial seizures with secondary generalisation 10.39 10.27 8 104151 247 29470121
Orthostatic tremor 10.37 10.27 3 104156 7 29470361
Rash pruritic 10.36 10.27 42 104117 22321 29448047
Lethargy 10.35 10.27 188 103971 37392 29432976
Peripheral artery thrombosis 10.33 10.27 23 104136 2099 29468269
Pharyngeal swelling 10.32 10.27 19 104140 1512 29468856
Accidental overdose 10.32 10.27 101 104058 17492 29452876
Personality disorder 10.32 10.27 16 104143 1107 29469261
Arthropathy 10.29 10.27 40 104119 21514 29448854
Hepatocellular carcinoma 10.28 10.27 6 104153 7032 29463336

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 1332.99 9.70 1161 253543 38121 64205907
Intentional self-injury 1236.40 9.70 979 253725 28065 64215963
Suicidal ideation 1113.00 9.70 1343 253361 65199 64178829
Intentional overdose 916.35 9.70 1428 253276 88516 64155512
Suicide attempt 903.58 9.70 1252 253452 69755 64174273
Drug abuse 759.17 9.70 1639 253065 130735 64113293
Drug interaction 675.12 9.70 3023 251681 359060 63884968
Depression 650.52 9.70 1890 252814 181401 64062627
Anxiety 619.46 9.70 1983 252721 200666 64043362
Completed suicide 559.79 9.70 2052 252652 222362 64021666
Agitation 476.63 9.70 1068 253636 87299 64156729
Tremor 401.36 9.70 1393 253311 146837 64097191
Toxicity to various agents 330.85 9.70 2511 252193 361002 63883026
Akathisia 328.84 9.70 309 254395 11201 64232827
Sopor 325.79 9.70 488 254216 29173 64214855
Synovitis 303.39 9.70 23 254681 99067 64144961
Aggression 292.04 9.70 596 254108 45636 64198392
Withdrawal syndrome 276.03 9.70 399 254305 23093 64220935
Overdose 260.94 9.70 1284 253420 158282 64085746
Somnolence 254.16 9.70 1522 253182 202123 64041905
Pyrexia 238.75 9.70 1266 253438 557378 63686650
Confusional state 236.72 9.70 1803 252901 259341 63984687
Mania 226.43 9.70 300 254404 15986 64228042
Paranoia 220.88 9.70 297 254407 16055 64227973
Bruxism 219.14 9.70 151 254553 3473 64240555
Drug intolerance 217.50 9.70 253 254451 187739 64056289
Restlessness 212.28 9.70 479 254225 39306 64204722
Abnormal behaviour 211.80 9.70 433 254271 33189 64210839
Hyponatraemia 210.81 9.70 1148 253556 147191 64096837
Hand deformity 209.15 9.70 9 254695 62762 64181266
Hallucination, auditory 208.26 9.70 294 254410 16645 64227383
Dyskinesia 204.36 9.70 469 254235 38919 64205109
Infusion related reaction 203.89 9.70 209 254495 164258 64079770
Irritability 201.20 9.70 447 254257 36299 64207729
Rheumatoid arthritis 201.16 9.70 211 254493 164083 64079945
Joint swelling 200.22 9.70 339 254365 215043 64028985
Febrile neutropenia 197.87 9.70 271 254433 187386 64056642
Panic attack 191.63 9.70 317 254387 20636 64223392
Extrapyramidal disorder 191.32 9.70 305 254399 19247 64224781
Psychotic disorder 189.74 9.70 421 254283 34157 64209871
Hallucination 188.13 9.70 674 254030 72114 64171914
Contraindicated product administered 184.06 9.70 98 254606 107731 64136297
Drug withdrawal syndrome 180.81 9.70 389 254315 30902 64213126
Treatment failure 177.27 9.70 122 254582 116694 64127334
Off label use 175.69 9.70 1626 253078 631180 63612848
Insomnia 164.29 9.70 1339 253365 196497 64047531
Acute kidney injury 158.99 9.70 1080 253624 448160 63795868
Anger 157.39 9.70 248 254456 15493 64228535
Mydriasis 154.15 9.70 242 254462 15070 64228958
Renal impairment 152.60 9.70 185 254519 134832 64109196
Dystonia 152.24 9.70 270 254434 18595 64225433
Malignant neoplasm progression 148.48 9.70 136 254568 112735 64131293
Arthropathy 148.44 9.70 155 254549 120812 64123216
Arthralgia 147.30 9.70 1082 253622 441178 63802850
Parkinsonism 147.25 9.70 229 254475 14144 64229884
Systemic lupus erythematosus 145.53 9.70 62 254642 77550 64166478
Obsessive-compulsive disorder 144.68 9.70 133 254571 4685 64239343
Homicidal ideation 143.28 9.70 112 254592 3145 64240883
Disturbance in attention 140.98 9.70 419 254285 40655 64203373
Delusion 140.48 9.70 254 254450 17760 64226268
Nasopharyngitis 135.88 9.70 364 254340 195709 64048319
Tic 134.99 9.70 99 254605 2520 64241508
Stomatitis 134.98 9.70 140 254564 109465 64134563
Rash 134.58 9.70 1161 253543 457388 63786640
Pericarditis 134.16 9.70 40 254664 62476 64181552
Thrombocytopenia 133.83 9.70 445 254259 223356 64020672
Depressed mood 133.83 9.70 411 254293 40601 64203427
Mood swings 133.30 9.70 244 254460 17224 64226804
Nightmare 125.92 9.70 265 254439 20728 64223300
Neutropenia 123.90 9.70 506 254198 239118 64004910
Electrocardiogram QT prolonged 123.85 9.70 631 254073 78817 64165211
Pancytopenia 123.73 9.70 236 254468 143073 64100955
Drug ineffective 123.46 9.70 2460 252244 837787 63406241
Bradykinesia 122.14 9.70 140 254564 6420 64237608
Hyperhidrosis 120.05 9.70 875 253829 124045 64119983
Self-injurious ideation 119.59 9.70 100 254604 3097 64240931
Muscle rigidity 118.38 9.70 232 254472 17241 64226787
Feeling abnormal 118.35 9.70 918 253786 132684 64111344
Psychomotor hyperactivity 118.12 9.70 208 254496 14243 64229785
Glossodynia 117.64 9.70 54 254650 64642 64179386
Hepatic enzyme increased 117.50 9.70 208 254496 129735 64114293
Apathy 116.52 9.70 180 254524 11052 64232976
Hypomania 116.12 9.70 127 254577 5527 64238501
Thinking abnormal 114.06 9.70 181 254523 11375 64232653
Seizure 113.82 9.70 1082 253622 165810 64078218
Anaemia 111.37 9.70 958 253746 377722 63866306
Loss of libido 110.83 9.70 85 254619 2319 64241709
Neuroleptic malignant syndrome 110.71 9.70 280 254424 24716 64219312
Hallucination, visual 110.20 9.70 299 254405 27535 64216493
Homicide 109.82 9.70 64 254640 1087 64242941
Disorientation 108.66 9.70 473 254231 55355 64188673
Social avoidant behaviour 107.15 9.70 110 254594 4447 64239581
Priapism 106.59 9.70 103 254601 3867 64240161
Colitis microscopic 106.55 9.70 139 254565 7293 64236735
Pneumonia 106.36 9.70 1563 253141 558013 63686015
Peripheral swelling 104.17 9.70 448 254256 208705 64035323
Treatment noncompliance 103.38 9.70 392 254312 43090 64200938
Loss of consciousness 102.20 9.70 964 253740 147401 64096627
Bradyphrenia 102.18 9.70 154 254550 9252 64234776
Intrusive thoughts 100.85 9.70 42 254662 325 64243703
Wound 100.74 9.70 92 254612 76385 64167643
Alopecia 98.63 9.70 330 254374 165360 64078668
Oromandibular dystonia 98.48 9.70 55 254649 858 64243170
Dizziness 98.26 9.70 2306 252398 427857 63816171
C-reactive protein increased 98.03 9.70 139 254565 94770 64149258
Cytomegalovirus infection 97.71 9.70 15 254689 37184 64206844
Cardiac failure 97.64 9.70 238 254466 132135 64111893
Blood prolactin increased 97.50 9.70 93 254611 3435 64240593
Therapeutic product effect decreased 96.92 9.70 193 254511 115158 64128870
General physical health deterioration 96.90 9.70 446 254258 203979 64040049
Catatonia 96.26 9.70 134 254570 7486 64236542
Inappropriate antidiuretic hormone secretion 95.93 9.70 247 254457 22042 64221986
Crying 95.26 9.70 231 254473 19859 64224169
Major depression 95.10 9.70 135 254569 7681 64236347
Sexual dysfunction 94.29 9.70 122 254582 6349 64237679
Myoclonus 91.72 9.70 262 254442 24856 64219172
Suicidal behaviour 89.23 9.70 81 254623 2806 64241222
Amnesia 88.68 9.70 402 254302 47867 64196161
Muscle twitching 88.54 9.70 217 254487 18781 64225247
Anorgasmia 88.52 9.70 52 254652 897 64243131
Tachyphrenia 87.96 9.70 67 254637 1809 64242219
Sepsis 87.78 9.70 541 254163 229800 64014228
Septic shock 87.22 9.70 178 254526 105259 64138769
Sleep disorder due to general medical condition, insomnia type 86.74 9.70 4 254700 26266 64217762
Delirium 86.68 9.70 518 254186 68676 64175352
Emotional distress 86.59 9.70 326 254378 35712 64208316
Neuropathy peripheral 85.34 9.70 213 254491 117312 64126716
Sinusitis 83.89 9.70 295 254409 145633 64098395
Libido decreased 83.89 9.70 99 254605 4685 64239343
Galactorrhoea 83.59 9.70 82 254622 3137 64240891
Rheumatoid factor positive 83.34 9.70 18 254686 34920 64209108
Infection 80.86 9.70 415 254289 184465 64059563
Poisoning deliberate 80.84 9.70 170 254534 13288 64230740
Hyperprolactinaemia 79.50 9.70 89 254615 3976 64240052
Mucosal inflammation 79.25 9.70 78 254626 62506 64181522
Maculopathy 79.06 9.70 71 254633 2425 64241603
Sedation 78.94 9.70 349 254355 41113 64202915
Psychomotor retardation 78.14 9.70 99 254605 5044 64238984
Mental disorder 78.02 9.70 256 254448 26189 64217839
Folliculitis 77.04 9.70 13 254691 30064 64213964
Helicobacter infection 76.25 9.70 28 254676 38334 64205694
Hyperreflexia 76.19 9.70 116 254588 7032 64236996
Fall 76.00 9.70 2169 252535 414657 63829371
Product substitution issue 75.91 9.70 197 254507 17664 64226364
C-reactive protein abnormal 75.64 9.70 12 254692 29035 64214993
Restless legs syndrome 75.03 9.70 191 254513 16925 64227103
Hypersensitivity 74.52 9.70 462 254242 195990 64048038
Pleural effusion 73.98 9.70 254 254450 126305 64117723
Disease progression 73.91 9.70 298 254406 141382 64102646
Drug hypersensitivity 72.95 9.70 1332 253372 236483 64007545
Trismus 72.35 9.70 93 254611 4808 64239220
Swelling 72.13 9.70 356 254348 159862 64084166
Duodenal ulcer perforation 71.00 9.70 24 254680 34601 64209427
Emotional disorder 69.71 9.70 154 254550 12453 64231575
Erectile dysfunction 69.54 9.70 154 254550 12473 64231555
Generalised tonic-clonic seizure 68.83 9.70 326 254378 39531 64204497
Anhedonia 68.66 9.70 161 254543 13545 64230483
Drug dependence 68.49 9.70 287 254417 33025 64211003
Obsessive thoughts 67.76 9.70 45 254659 972 64243056
Dysarthria 67.67 9.70 434 254270 58972 64185056
Euphoric mood 67.49 9.70 105 254599 6486 64237542
Affective disorder 66.23 9.70 104 254600 6476 64237552
Lower respiratory tract infection 65.22 9.70 176 254528 94438 64149590
Bone marrow failure 65.17 9.70 56 254648 47896 64196132
Product use issue 64.95 9.70 343 254361 151372 64092656
Schizophrenia 64.69 9.70 139 254565 11029 64232999
Foaming at mouth 64.50 9.70 54 254650 1675 64242353
Activation syndrome 64.47 9.70 28 254676 243 64243785
Platelet count decreased 64.33 9.70 393 254311 167318 64076710
Negative thoughts 63.85 9.70 48 254656 1270 64242758
Abnormal dreams 63.59 9.70 132 254572 10224 64233804
Blister 62.54 9.70 142 254562 80825 64163203
Speech disorder 62.18 9.70 365 254339 48076 64195952
Impulsive behaviour 62.10 9.70 64 254640 2599 64241429
Alcoholism 62.06 9.70 72 254632 3345 64240683
Impaired healing 62.01 9.70 89 254615 60384 64183644
Gestational diabetes 61.40 9.70 92 254612 5498 64238530
Hallucinations, mixed 60.01 9.70 95 254609 5957 64238071
Tardive dyskinesia 59.93 9.70 120 254584 9058 64234970
Amenorrhoea 59.88 9.70 99 254605 6440 64237588
Respiratory arrest 59.06 9.70 385 254319 52600 64191428
Inflammation 58.57 9.70 105 254599 65195 64178833
Muscle injury 58.40 9.70 16 254688 26421 64217607
Hyperkalaemia 58.40 9.70 204 254500 100925 64143103
Yawning 58.27 9.70 44 254660 1172 64242856
Hepatic function abnormal 58.06 9.70 103 254601 64210 64179818
Abulia 55.94 9.70 38 254666 853 64243175
Flat affect 55.25 9.70 51 254653 1806 64242222
Memory impairment 54.68 9.70 548 254156 85134 64158894
Psychotic symptom 54.65 9.70 54 254650 2084 64241944
Mental impairment 54.44 9.70 165 254539 16178 64227850
Derealisation 54.35 9.70 46 254658 1449 64242579
Persistent genital arousal disorder 54.04 9.70 24 254680 221 64243807
Salivary hypersecretion 53.96 9.70 136 254568 11977 64232051
Torticollis 53.83 9.70 54 254650 2123 64241905
Ascites 52.70 9.70 103 254601 61898 64182130
Tension 52.24 9.70 70 254634 3770 64240258
Blood creatinine increased 52.15 9.70 318 254386 135464 64108564
Pneumocystis jirovecii pneumonia 51.91 9.70 22 254682 27612 64216416
Intentional product misuse 51.88 9.70 474 254230 71821 64172207
Arthritis 51.88 9.70 164 254540 83650 64160378
Genital hypoaesthesia 51.50 9.70 21 254683 153 64243875
Blepharospasm 51.33 9.70 65 254639 3310 64240718
Dyspnoea 51.19 9.70 2319 252385 716355 63527673
Mood altered 51.06 9.70 159 254545 15820 64228208
Disturbance in sexual arousal 50.93 9.70 21 254683 158 64243870
Bipolar I disorder 49.54 9.70 47 254657 1724 64242304
Interstitial lung disease 49.43 9.70 208 254496 97524 64146504
Haemophagocytic lymphohistiocytosis 48.85 9.70 6 254698 17603 64226425
Hypersomnia 48.73 9.70 180 254524 19537 64224491
White blood cell count decreased 47.77 9.70 396 254308 157441 64086587
Musculoskeletal pain 47.60 9.70 163 254541 81131 64162897
Infarction 47.59 9.70 68 254636 3892 64240136
Antipsychotic drug level increased 47.59 9.70 78 254626 5037 64238991
Depersonalisation/derealisation disorder 46.79 9.70 44 254660 1596 64242432
Alcohol poisoning 46.70 9.70 70 254634 4185 64239843
Depressive symptom 46.56 9.70 72 254632 4424 64239604
Drug reaction with eosinophilia and systemic symptoms 46.13 9.70 90 254614 54127 64189901
Discomfort 46.12 9.70 164 254540 80714 64163314
Basal cell carcinoma 45.71 9.70 33 254671 30805 64213223
Lung disorder 45.63 9.70 108 254596 60592 64183436
Bronchopulmonary aspergillosis 45.18 9.70 10 254694 19075 64224953
Neutrophil count decreased 45.05 9.70 155 254549 77041 64166987
Balance disorder 44.82 9.70 518 254186 83408 64160620
Poisoning 44.58 9.70 188 254516 21691 64222337
Dissociation 44.23 9.70 57 254647 2954 64241074
Reversible cerebral vasoconstriction syndrome 43.63 9.70 50 254654 2292 64241736
Burning mouth syndrome 43.29 9.70 26 254678 468 64243560
Blood creatine phosphokinase increased 43.06 9.70 386 254318 58172 64185856
Flashback 42.88 9.70 21 254683 246 64243782
Intentional product use issue 42.83 9.70 212 254492 95152 64148876
Confabulation 42.42 9.70 25 254679 434 64243594
Dysphoria 42.30 9.70 68 254636 4320 64239708
Gastrointestinal disorder 42.29 9.70 196 254508 89513 64154515
Eye movement disorder 42.03 9.70 89 254615 6990 64237038
Emotional poverty 41.60 9.70 29 254675 680 64243348
Renal failure 41.11 9.70 489 254215 181199 64062829
Product complaint 41.06 9.70 122 254582 11832 64232196
Vertigo 40.87 9.70 384 254320 58627 64185401
Drug resistance 40.80 9.70 47 254657 35055 64208973
Pain in extremity 40.77 9.70 899 253805 302186 63941842
Muscle tightness 40.64 9.70 116 254588 10999 64233029
Hyponatraemic seizure 40.39 9.70 25 254679 476 64243552
Herpes zoster 40.37 9.70 168 254536 79019 64165009
Drug eruption 40.28 9.70 50 254654 36086 64207942
Persistent depressive disorder 40.27 9.70 33 254671 993 64243035
Ill-defined disorder 40.26 9.70 70 254634 43982 64200046
Myelosuppression 40.14 9.70 22 254682 23808 64220220
Formication 39.94 9.70 66 254638 4291 64239737
Sensation of foreign body 39.89 9.70 67 254637 4415 64239613
Violence-related symptom 39.78 9.70 28 254676 667 64243361
Leukopenia 39.45 9.70 236 254468 101006 64143022
Transplant rejection 39.45 9.70 10 254694 17391 64226637
Haematotoxicity 39.44 9.70 3 254701 12893 64231135
Cholecystitis chronic 39.02 9.70 102 254602 9185 64234843
Psychomotor skills impaired 39.02 9.70 61 254643 3784 64240244
Bipolar disorder 38.99 9.70 84 254620 6677 64237351
Tumour lysis syndrome 38.95 9.70 14 254690 19426 64224602
Pain 38.93 9.70 1788 252916 551723 63692305
Thrombotic microangiopathy 38.88 9.70 9 254695 16646 64227382
Abdominal discomfort 38.88 9.70 497 254207 181825 64062203
Erythema 38.76 9.70 513 254191 186557 64057471
Poverty of thought content 38.68 9.70 13 254691 50 64243978
Fear 38.55 9.70 170 254534 20001 64224027
Cycloplegia 38.27 9.70 9 254695 3 64244025
Injection site pain 38.18 9.70 270 254434 111138 64132890
Depression suicidal 38.17 9.70 48 254656 2427 64241601
Death 37.94 9.70 1540 253164 481165 63762863
Drowning 37.90 9.70 28 254676 721 64243307
Uterine perforation 37.88 9.70 76 254628 5744 64238284
Psoriatic arthropathy 37.56 9.70 71 254633 43210 64200818
Abnormal weight gain 37.49 9.70 45 254659 2168 64241860
Cogwheel rigidity 37.28 9.70 51 254653 2802 64241226
Somnambulism 36.95 9.70 70 254634 5071 64238957
Pruritus 36.93 9.70 945 253759 311455 63932573
Disseminated intravascular coagulation 36.86 9.70 44 254660 32304 64211724
Cough 36.79 9.70 910 253794 301238 63942790
Disorganised speech 35.53 9.70 38 254666 1612 64242416
Dysphemia 35.21 9.70 52 254652 3067 64240961
Semen discolouration 35.15 9.70 9 254695 8 64244020
Drug screen positive 35.15 9.70 73 254631 5656 64238372
Self esteem decreased 34.96 9.70 29 254675 888 64243140
Paraesthesia 34.95 9.70 735 253969 133787 64110241
Skin ulcer 34.87 9.70 76 254628 43898 64200130
Sleep disorder 34.82 9.70 375 254329 59334 64184694
Bone erosion 34.62 9.70 3 254701 11592 64232436
Clonus 34.55 9.70 75 254629 5992 64238036
Syncope 34.31 9.70 840 253864 156795 64087233
Ejaculation failure 34.25 9.70 20 254684 341 64243687
Myelodysplastic syndrome 34.19 9.70 35 254669 27544 64216484
Overweight 33.84 9.70 53 254651 3293 64240735
Knee arthroplasty 33.77 9.70 34 254670 26965 64217063
Food interaction 33.77 9.70 35 254669 1431 64242597
Premature ejaculation 33.36 9.70 12 254692 59 64243969
Lethargy 33.11 9.70 435 254269 72159 64171869
Ideas of reference 33.05 9.70 15 254689 146 64243882
Palpitations 32.95 9.70 588 254116 103900 64140128
Nephropathy toxic 32.81 9.70 14 254690 17500 64226528
Cytokine release syndrome 32.59 9.70 21 254683 20808 64223220
Somatic symptom disorder of pregnancy 32.32 9.70 13 254691 91 64243937
Palmar-plantar erythrodysaesthesia syndrome 31.99 9.70 40 254664 28779 64215249
Injury 31.89 9.70 350 254354 55642 64188386
Cardiac arrest 31.76 9.70 815 253889 153249 64090779
Acute myeloid leukaemia 31.67 9.70 37 254667 27426 64216602
Stiff person syndrome 31.62 9.70 17 254687 245 64243783
Orgasm abnormal 31.61 9.70 15 254689 163 64243865
Pneumonitis 31.55 9.70 98 254606 50267 64193761
Hip arthroplasty 31.44 9.70 23 254681 21328 64222700
Lymphadenopathy 31.30 9.70 88 254616 46598 64197430
Sleep-related eating disorder 31.19 9.70 24 254680 658 64243370
Tubulointerstitial nephritis 31.18 9.70 46 254658 30863 64213165
Attention deficit hyperactivity disorder 31.01 9.70 46 254658 2724 64241304
Negativism 31.00 9.70 25 254679 735 64243293
Atrial fibrillation 30.93 9.70 482 254222 170607 64073421
COVID-19 30.89 9.70 142 254562 64998 64179030
Haemoglobin decreased 30.88 9.70 563 254141 194500 64049528
Multiple organ dysfunction syndrome 30.87 9.70 254 254450 101159 64142869
Mutism 30.66 9.70 39 254665 1995 64242033
Urinary incontinence 30.65 9.70 246 254458 35905 64208123
Retroplacental haematoma 30.53 9.70 13 254691 107 64243921
Heavy menstrual bleeding 30.47 9.70 111 254593 11966 64232062
Dementia with Lewy bodies 30.43 9.70 24 254680 683 64243345
Pregnancy with implant contraceptive 30.27 9.70 33 254671 1431 64242597
Device dislocation 30.09 9.70 164 254540 21014 64223014
Osteoporosis 29.96 9.70 77 254627 42003 64202025
Platelet aggregation abnormal 29.80 9.70 9 254695 22 64244006
Middle insomnia 29.70 9.70 115 254589 12762 64231266
Adrenal insufficiency 29.66 9.70 27 254677 22460 64221568
Cerebral vasoconstriction 29.64 9.70 30 254674 1192 64242836
Action tremor 29.58 9.70 19 254685 387 64243641
Prostate cancer 29.58 9.70 21 254683 19774 64224254
Cytopenia 29.57 9.70 12 254692 15459 64228569
Victim of chemical submission 29.47 9.70 17 254687 283 64243745
Chronic kidney disease 29.44 9.70 123 254581 57796 64186232
Graft versus host disease 29.34 9.70 9 254695 13804 64230224
Urinary hesitation 29.30 9.70 51 254653 3459 64240569
Cytomegalovirus viraemia 29.29 9.70 4 254700 10824 64233204
Rash maculo-papular 29.10 9.70 92 254612 46934 64197094
Schizoaffective disorder bipolar type 29.06 9.70 13 254691 122 64243906
Pressure of speech 28.83 9.70 27 254677 974 64243054
Anaphylactic shock 28.81 9.70 47 254657 30281 64213747
Blood pressure fluctuation 28.37 9.70 107 254597 51764 64192264
Pancreatic fibrosis 28.37 9.70 12 254692 97 64243931
Nervousness 28.34 9.70 207 254497 29349 64214679
Grandiosity 28.31 9.70 21 254683 544 64243484
Device expulsion 28.25 9.70 161 254543 20975 64223053
Tinnitus 28.25 9.70 231 254473 33902 64210126
Proteinuria 28.22 9.70 41 254663 27682 64216346
Injection site erythema 28.13 9.70 164 254540 70636 64173392
Acute psychosis 28.11 9.70 52 254652 3700 64240328
Urine sodium decreased 28.07 9.70 16 254688 260 64243768
Male sexual dysfunction 28.07 9.70 14 254690 171 64243857
Central vision loss 27.92 9.70 8 254696 15 64244013
Posture abnormal 27.80 9.70 49 254655 3357 64240671
Tongue spasm 27.72 9.70 11 254693 74 64243954
Respiratory failure 27.50 9.70 459 254245 160724 64083304
Psychiatric symptom 27.49 9.70 70 254634 6203 64237825
Complication of device insertion 27.46 9.70 61 254643 4951 64239077
Delusion of replacement 27.34 9.70 13 254691 142 64243886
Rabbit syndrome 27.14 9.70 17 254687 331 64243697
Physical assault 27.12 9.70 32 254672 1514 64242514
Pathogen resistance 26.95 9.70 8 254696 12535 64231493
Hereditary angioedema 26.90 9.70 52 254652 3824 64240204
Irritable bowel syndrome 26.90 9.70 68 254636 37301 64206727
Upper gastrointestinal haemorrhage 26.84 9.70 234 254470 34986 64209042
Osteonecrosis of jaw 26.75 9.70 75 254629 39750 64204278
Cataract 26.60 9.70 108 254596 51154 64192874
Libido disorder 26.58 9.70 15 254689 239 64243789
Dissociative disorder 26.54 9.70 18 254686 403 64243625
Alanine aminotransferase increased 26.39 9.70 388 254316 138643 64105385
Cognitive disorder 26.35 9.70 333 254371 54754 64189274
Aspergillus infection 26.34 9.70 16 254688 16363 64227665
Rheumatic fever 26.19 9.70 3 254701 9291 64234737
Antidepressant drug level increased 26.18 9.70 17 254687 353 64243675
Antisocial behaviour 26.16 9.70 20 254684 543 64243485
Hypertonia 26.10 9.70 69 254635 6256 64237772
Tearfulness 25.74 9.70 57 254647 4616 64239412
Phobia 25.60 9.70 17 254687 367 64243661
Respiratory tract infection 25.45 9.70 70 254634 37337 64206691
Neoplasm progression 25.45 9.70 80 254624 40884 64203144
Acute graft versus host disease 25.43 9.70 3 254701 9081 64234947
Diffuse large B-cell lymphoma 25.41 9.70 5 254699 10356 64233672
Cellulitis 25.24 9.70 242 254462 93415 64150613
Device placement issue 25.18 9.70 22 254682 724 64243304
Tachycardia 25.15 9.70 771 253933 148808 64095220
Chorea 25.01 9.70 35 254669 1965 64242063
Injection site pruritus 24.84 9.70 72 254632 37754 64206274
Injection site bruising 24.80 9.70 68 254636 36305 64207723
Drug dose titration not performed 24.80 9.70 21 254683 662 64243366
Idiopathic intracranial hypertension 24.75 9.70 40 254664 2553 64241475
Miosis 24.74 9.70 111 254593 13155 64230873
Affect lability 24.72 9.70 85 254619 8905 64235123
Febrile bone marrow aplasia 24.51 9.70 7 254697 11248 64232780
Suppressed lactation 24.45 9.70 15 254689 281 64243747
Dystonic tremor 24.39 9.70 13 254691 184 64243844
Intermenstrual bleeding 24.37 9.70 59 254645 5066 64238962
Persecutory delusion 24.37 9.70 52 254652 4106 64239922
Hypercalcaemia 24.33 9.70 55 254649 31361 64212667
Nystagmus 24.29 9.70 85 254619 8983 64235045
Pseudomonas infection 24.16 9.70 21 254683 17862 64226166
Mental status changes 24.05 9.70 357 254347 60805 64183223
Swollen tongue 23.97 9.70 227 254477 34727 64209301
Post-traumatic stress disorder 23.97 9.70 52 254652 4153 64239875
Cardio-respiratory arrest 23.76 9.70 532 254172 97861 64146167
Factor XIII deficiency 23.73 9.70 10 254694 80 64243948
Morbid thoughts 23.68 9.70 21 254683 705 64243323
Personality change 23.41 9.70 81 254623 8512 64235516
Exposure during pregnancy 23.39 9.70 434 254270 77241 64166787
Vanishing bile duct syndrome 23.35 9.70 27 254677 1250 64242778
Creatinine renal clearance decreased 23.31 9.70 14 254690 14407 64229621
Borderline personality disorder 23.30 9.70 22 254682 802 64243226
Decreased interest 23.23 9.70 45 254659 3315 64240713
Radiologically isolated syndrome 23.09 9.70 6 254698 6 64244022
Phospholipidosis 23.07 9.70 11 254693 121 64243907
Drug screen false positive 23.02 9.70 24 254680 988 64243040
Hallucination, olfactory 23 9.70 17 254687 438 64243590
Hyperuricaemia 22.83 9.70 6 254698 10185 64233843
Hyponatraemic syndrome 22.79 9.70 21 254683 742 64243286
Peritonitis 22.65 9.70 40 254664 24983 64219045
Pleurothotonus 22.64 9.70 36 254668 2266 64241762
Gaze palsy 22.54 9.70 38 254666 2512 64241516
Headache 22.41 9.70 2403 252301 527064 63716964
Ankylosing spondylitis 22.37 9.70 3 254701 8231 64235797
Rheumatoid nodule 22.32 9.70 11 254693 12640 64231388
Granulocytopenia 22.28 9.70 91 254613 10349 64233679
Hepatic failure 22.17 9.70 128 254576 55266 64188762
Feeling jittery 22.15 9.70 92 254612 10543 64233485
Hallucination, gustatory 22.14 9.70 9 254695 65 64243963
Muscle contractions involuntary 22.14 9.70 43 254661 3174 64240854
Metabolic syndrome 22.11 9.70 36 254668 2312 64241716
Heat stroke 22.09 9.70 28 254676 1427 64242601
Diplopia 22.07 9.70 181 254523 26584 64217444
Oedema peripheral 22.03 9.70 647 254057 209670 64034358
Judgement impaired 21.86 9.70 24 254680 1049 64242979
Environmental exposure 21.84 9.70 15 254689 343 64243685
Therapeutic response unexpected 21.74 9.70 128 254576 16873 64227155
Generalised anxiety disorder 21.73 9.70 32 254672 1883 64242145
Embedded device 21.70 9.70 39 254665 2713 64241315
Distractibility 21.70 9.70 19 254685 627 64243401
Localised infection 21.62 9.70 55 254649 30106 64213922
Amniotic fluid volume increased 21.59 9.70 11 254693 141 64243887
Delusional disorder, unspecified type 21.55 9.70 20 254684 713 64243315
Acute respiratory distress syndrome 21.50 9.70 80 254624 38855 64205173
Suspected suicide 21.38 9.70 79 254625 8575 64235453
Cystitis haemorrhagic 21.37 9.70 3 254701 7953 64236075
Second primary malignancy 21.35 9.70 11 254693 12326 64231702
Photophobia 21.35 9.70 129 254575 17164 64226864
Psychogenic seizure 21.23 9.70 31 254673 1810 64242218
Rapid eye movements sleep abnormal 21.17 9.70 13 254691 244 64243784
Macrophages increased 21.16 9.70 12 254692 193 64243835
Resting tremor 21.14 9.70 27 254677 1387 64242641
Prader-Willi syndrome 21.02 9.70 6 254698 11 64244017
Stress 21.01 9.70 346 254358 60188 64183840
Blood bilirubin increased 20.95 9.70 137 254567 57416 64186612
Unresponsive to stimuli 20.95 9.70 297 254407 50096 64193932
Social anxiety disorder 20.94 9.70 16 254688 434 64243594
Male orgasmic disorder 20.93 9.70 8 254696 48 64243980
Postmortem blood drug level increased 20.91 9.70 20 254684 741 64243287
Mitochondrial encephalomyopathy 20.81 9.70 7 254697 27 64244001
Vision blurred 20.77 9.70 485 254219 89831 64154197
Apallic syndrome 20.68 9.70 21 254683 838 64243190
Coordination abnormal 20.67 9.70 115 254589 14849 64229179
Polyneuropathy 20.67 9.70 29 254675 19865 64224163
Coma 20.61 9.70 472 254232 87143 64156885
Foreign body in reproductive tract 20.60 9.70 16 254688 445 64243583
Fungal infection 20.50 9.70 68 254636 34183 64209845
Aplastic anaemia 20.49 9.70 15 254689 13905 64230123
Blood calcium decreased 20.40 9.70 44 254660 25510 64218518
Enterocolitis 20.38 9.70 11 254693 12007 64232021
Neutropenic sepsis 20.35 9.70 38 254666 23234 64220794
Weight increased 20.15 9.70 1033 253671 212315 64031713
Metabolic acidosis 20.13 9.70 181 254523 70777 64173251
Heart rate decreased 20.08 9.70 131 254573 54936 64189092
Urinary retention 20.06 9.70 289 254415 48912 64195116
Inappropriate affect 19.90 9.70 25 254679 1263 64242765
Parkinsonism hyperpyrexia syndrome 19.88 9.70 12 254692 218 64243810
Gallbladder cholesterolosis 19.81 9.70 17 254687 546 64243482
Loose associations 19.77 9.70 8 254696 57 64243971
Diverticulitis 19.63 9.70 82 254622 38536 64205492
Parasomnia 19.59 9.70 16 254688 479 64243549
Liver disorder 19.41 9.70 127 254577 53224 64190804
Cardiac failure congestive 19.39 9.70 381 254323 130199 64113829
Tongue biting 19.38 9.70 29 254675 1731 64242297
Morose 19.36 9.70 7 254697 35 64243993
Oral candidiasis 19.34 9.70 39 254665 23173 64220855
Transient psychosis 19.31 9.70 8 254696 61 64243967
Impaired reasoning 19.28 9.70 9 254695 94 64243934
Tuberculosis 19.26 9.70 14 254690 13024 64231004
Dyspnoea exertional 19.23 9.70 192 254512 73538 64170490
Lid lag 19.20 9.70 8 254696 62 64243966
Panic disorder 19.15 9.70 37 254667 2720 64241308
Parkinsonian gait 19.07 9.70 20 254684 829 64243199
Lactic acidosis 19.05 9.70 153 254551 61257 64182771
Personality disorder 19.04 9.70 51 254653 4660 64239368
Muscle contracture 19.00 9.70 32 254672 2113 64241915
Multiple sclerosis relapse 18.97 9.70 247 254457 40888 64203140
Immunosuppressant drug level increased 18.90 9.70 3 254701 7256 64236772
Neurotoxicity 18.86 9.70 51 254653 27353 64216675
Hypotension 18.73 9.70 1274 253430 379700 63864328
Perinatal depression 18.71 9.70 13 254691 303 64243725
Plasma cell myeloma 18.69 9.70 106 254598 45969 64198059
Urticaria 18.63 9.70 441 254263 146876 64097152
Dermatillomania 18.56 9.70 11 254693 193 64243835
Hyperacusis 18.56 9.70 30 254674 1915 64242113
Conversion disorder 18.47 9.70 28 254676 1691 64242337
Excessive masturbation 18.36 9.70 8 254696 70 64243958
Eosinophilic pneumonia acute 18.35 9.70 20 254684 867 64243161
Bleeding time prolonged 18.29 9.70 23 254681 1163 64242865
Catastrophic reaction 18.29 9.70 6 254698 21 64244007
Movement disorder 18.26 9.70 149 254555 21851 64222177
Hyperbilirubinaemia 18.21 9.70 35 254669 21170 64222858
Intracranial meningioma malignant 18.15 9.70 4 254700 0 64244028
Hypoalbuminaemia 18.12 9.70 26 254678 17648 64226380
Haemolytic anaemia 18.11 9.70 22 254682 16031 64227997
Sexual activity increased 18.07 9.70 6 254698 22 64244006
Pseudodementia 18.07 9.70 6 254698 22 64244006
Hypocalcaemia 18.07 9.70 94 254610 41659 64202369
Reduced facial expression 18.03 9.70 31 254673 2082 64241946
Red blood cell sedimentation rate increased 18.03 9.70 63 254641 31172 64212856
Glomerular filtration rate decreased 17.97 9.70 31 254673 19541 64224487
Negative symptoms in schizophrenia 17.97 9.70 9 254695 111 64243917
Disinhibition 17.96 9.70 32 254672 2211 64241817
Dopamine dysregulation syndrome 17.95 9.70 15 254689 464 64243564
Metastases to lymph nodes 17.94 9.70 6 254698 8711 64235317
Biliary dyskinesia 17.93 9.70 33 254671 2339 64241689
Polymenorrhoea 17.93 9.70 20 254684 890 64243138
Aplasia 17.82 9.70 3 254701 6950 64237078
Drop attacks 17.79 9.70 21 254683 994 64243034
Feelings of worthlessness 17.76 9.70 15 254689 471 64243557
Epstein-Barr virus infection 17.69 9.70 14 254690 12474 64231554
Influenza 17.63 9.70 305 254399 106226 64137802
Hypoaesthesia eye 17.62 9.70 8 254696 78 64243950
Drug-device interaction 17.62 9.70 8 254696 78 64243950
Pneumonia bacterial 17.61 9.70 20 254684 15015 64229013
Incoherent 17.60 9.70 65 254639 7053 64236975
Alanine aminotransferase abnormal 17.59 9.70 3 254701 6885 64237143
Product use in unapproved indication 17.59 9.70 547 254157 176071 64067957
Oxygen saturation decreased 17.37 9.70 308 254396 106868 64137160
Blood pressure diastolic abnormal 17.34 9.70 13 254691 11904 64232124
Aspartate aminotransferase increased 17.33 9.70 351 254353 119437 64124591
BK virus infection 17.31 9.70 4 254700 7408 64236620
Diaphragmatic rupture 17.30 9.70 11 254693 220 64243808
Target skin lesion 17.29 9.70 9 254695 121 64243907
Conjunctival abrasion 17.24 9.70 5 254699 10 64244018
Lipidosis 17.24 9.70 5 254699 10 64244018
Long QT syndrome 17.22 9.70 52 254652 5087 64238941
Haemoptysis 17.22 9.70 118 254586 48930 64195098
Kidney transplant rejection 17.19 9.70 8 254696 9503 64234525
Ejection fraction decreased 17.18 9.70 57 254647 28650 64215378
Caesarean section 17.17 9.70 89 254615 11185 64232843
Metastases to lung 17.14 9.70 21 254683 15243 64228785
Foetal death 17.13 9.70 57 254647 5873 64238155
Depressed level of consciousness 17.12 9.70 432 254272 81004 64163024
Rales 17.05 9.70 21 254683 15208 64228820
Cardiogenic shock 17.02 9.70 68 254636 32359 64211669
Agitated depression 17.01 9.70 12 254692 287 64243741
Pulmonary haemorrhage 16.98 9.70 16 254688 13093 64230935
Accommodation disorder 16.98 9.70 15 254689 501 64243527
Aphasia 16.97 9.70 241 254463 40665 64203363
Oral discomfort 16.95 9.70 72 254632 8334 64235694
Communication disorder 16.92 9.70 42 254662 3664 64240364
Cardiac failure acute 16.80 9.70 24 254680 16320 64227708
Cold sweat 16.79 9.70 117 254587 16338 64227690
Feeling drunk 16.73 9.70 45 254659 4122 64239906
Erythromelalgia 16.70 9.70 10 254694 179 64243849
Illness anxiety disorder 16.59 9.70 11 254693 237 64243791
Therapeutic product effect incomplete 16.58 9.70 298 254406 103184 64140844
Dysgraphia 16.55 9.70 40 254664 3431 64240597
Urine chloride decreased 16.54 9.70 8 254696 91 64243937
Suicide threat 16.50 9.70 7 254697 57 64243971
Postural orthostatic tachycardia syndrome 16.49 9.70 15 254689 521 64243507
Enuresis 16.47 9.70 35 254669 2755 64241273
Eczema 16.45 9.70 61 254643 29659 64214369
Ataxia 16.45 9.70 146 254558 21938 64222090
Acute myocardial infarction 16.39 9.70 186 254518 69532 64174496
Pre-eclampsia 16.34 9.70 58 254646 6173 64237855
Serum serotonin decreased 16.34 9.70 5 254699 13 64244015
Torsade de pointes 16.30 9.70 121 254583 17242 64226786
Conjunctivitis 16.28 9.70 35 254669 20319 64223709
Oral herpes 16.18 9.70 40 254664 22112 64221916
Gout 16.17 9.70 38 254666 21375 64222653
Metastases to liver 16.14 9.70 45 254659 23896 64220132
Ejaculation delayed 16.14 9.70 9 254695 140 64243888
Screaming 16.11 9.70 40 254664 3489 64240539
Blood pressure increased 16.08 9.70 539 254165 172013 64072015
Feeling guilty 16.06 9.70 18 254686 805 64243223
Gastrointestinal motility disorder 16.06 9.70 51 254653 5128 64238900
Drug abuser 16.04 9.70 55 254649 5753 64238275
Substance abuse 16.03 9.70 76 254628 9216 64234812
Glucose tolerance impaired in pregnancy 15.93 9.70 4 254700 3 64244025
Joint hyperextension 15.89 9.70 11 254693 255 64243773
Schizoaffective disorder 15.86 9.70 25 254679 1562 64242466
Peripheral sensory neuropathy 15.81 9.70 13 254691 11365 64232663
Cerebral infarction 15.81 9.70 96 254608 40948 64203080
Rebound psychosis 15.81 9.70 9 254695 146 64243882
Anorectal discomfort 15.68 9.70 35 254669 2850 64241178
Product odour abnormal 15.66 9.70 21 254683 1132 64242896
Colitis 15.64 9.70 152 254552 58522 64185506
Collagen-vascular disease 15.62 9.70 7 254697 66 64243962
Ophthalmic vein thrombosis 15.60 9.70 10 254694 203 64243825
Death of relative 15.60 9.70 10 254694 203 64243825
Periodic limb movement disorder 15.59 9.70 9 254695 150 64243878
Hyperphagia 15.57 9.70 30 254674 2201 64241827
Bladder dilatation 15.56 9.70 27 254677 1827 64242201
Skin infection 15.54 9.70 22 254682 15015 64229013
Cholangitis 15.44 9.70 12 254692 10790 64233238
Brain injury 15.41 9.70 79 254625 9886 64234142
Abortion missed 15.39 9.70 21 254683 1151 64242877
Hepatocellular carcinoma 15.29 9.70 7 254697 8396 64235632
COVID-19 pneumonia 15.28 9.70 26 254678 16478 64227550
Injection site swelling 15.27 9.70 98 254606 41255 64202773
Soliloquy 15.26 9.70 15 254689 575 64243453
Marital problem 15.26 9.70 10 254694 211 64243817
CYP3A4 polymorphism 15.26 9.70 7 254697 70 64243958
Alcohol interaction 15.19 9.70 45 254659 4356 64239672
Maternal exposure during breast feeding 15.18 9.70 28 254676 1988 64242040
Mobility decreased 15.11 9.70 243 254461 85597 64158431
Selective mutism 15.09 9.70 7 254697 72 64243956
Menopausal disorder 15.04 9.70 6 254698 41 64243987
Rhinovirus infection 15.03 9.70 3 254701 6153 64237875
Therapy non-responder 15.03 9.70 177 254527 65722 64178306
Fear of weight gain 14.92 9.70 5 254699 19 64244009
Polyarthritis 14.92 9.70 10 254694 9705 64234323
Dementia Alzheimer's type 14.92 9.70 19 254685 973 64243055
Oesophageal pain 14.92 9.70 37 254667 3226 64240802
Pulmonary tuberculosis 14.89 9.70 5 254699 7239 64236789
Coagulopathy 14.88 9.70 70 254634 31850 64212178
Metastases to bone 14.85 9.70 37 254667 20398 64223630
Unintended pregnancy 14.82 9.70 36 254668 3098 64240930
Pharyngeal swelling 14.80 9.70 52 254652 5507 64238521
Complication of device removal 14.79 9.70 37 254667 3243 64240785
Optic ischaemic neuropathy 14.77 9.70 32 254672 2553 64241475
Postpartum haemorrhage 14.74 9.70 23 254681 1424 64242604
Differential white blood cell count abnormal 14.72 9.70 26 254678 1784 64242244
Panic reaction 14.69 9.70 42 254662 3985 64240043
Tenosynovitis 14.69 9.70 15 254689 11818 64232210
Head injury 14.64 9.70 196 254508 32646 64211382
Reflexes abnormal 14.60 9.70 17 254687 793 64243235
Daydreaming 14.60 9.70 17 254687 793 64243235
Body mass index increased 14.58 9.70 24 254680 1555 64242473
Skin toxicity 14.57 9.70 4 254700 6598 64237430
Morning sickness 14.57 9.70 13 254691 440 64243588
Renal injury 14.57 9.70 24 254680 15405 64228623
Jaundice 14.53 9.70 122 254582 48390 64195638
Obsessive rumination 14.51 9.70 4 254700 6 64244022
Partner stress 14.50 9.70 11 254693 295 64243733
Menopause 14.50 9.70 25 254679 1683 64242345
Diarrhoea 14.46 9.70 2573 252131 720131 63523897
Paraneoplastic rash 14.44 9.70 7 254697 80 64243948
Hypersexuality 14.37 9.70 23 254681 1456 64242572
Vascular dementia 14.33 9.70 17 254687 809 64243219
Gallbladder injury 14.22 9.70 20 254684 1128 64242900
Asphyxia 14.22 9.70 75 254629 9491 64234537
Petit mal epilepsy 14.21 9.70 48 254656 4984 64239044
Bronchitis 14.18 9.70 324 254380 108419 64135609
Subchorionic haemorrhage 14.09 9.70 8 254696 129 64243899
Menstruation irregular 14.05 9.70 44 254660 4391 64239637
Pyromania 14.00 9.70 5 254699 24 64244004
Basophil count abnormal 14.00 9.70 5 254699 24 64244004
Multiple sclerosis 13.99 9.70 125 254579 18816 64225212
Cardiotoxicity 13.96 9.70 12 254692 10262 64233766
Water intoxication 13.95 9.70 16 254688 734 64243294
Helplessness 13.89 9.70 11 254693 315 64243713
Tunnel vision 13.86 9.70 19 254685 1046 64242982
Dependence 13.86 9.70 28 254676 2127 64241901
Levator syndrome 13.83 9.70 5 254699 25 64244003
Skin necrosis 13.80 9.70 22 254682 14307 64229721
Device related infection 13.79 9.70 68 254636 30558 64213470
Anal incontinence 13.76 9.70 105 254599 15091 64228937
Haemorrhagic hepatic cyst 13.72 9.70 6 254698 53 64243975
Obsessive-compulsive symptom 13.72 9.70 8 254696 136 64243892
Blood parathyroid hormone decreased 13.62 9.70 6 254698 7360 64236668
Overconfidence 13.62 9.70 3 254701 0 64244028
Postictal headache 13.62 9.70 3 254701 0 64244028
Olfactory nerve disorder 13.62 9.70 3 254701 0 64244028
Arterial ligation 13.62 9.70 3 254701 0 64244028
Anaplastic large cell lymphoma T- and null-cell types stage IV 13.62 9.70 3 254701 0 64244028
Respiratory tract congestion 13.61 9.70 27 254677 16138 64227890
Oropharyngeal pain 13.58 9.70 258 254446 88609 64155419
Hyporesponsive to stimuli 13.58 9.70 25 254679 1772 64242256
Therapeutic response decreased 13.57 9.70 136 254568 52052 64191976
Haematuria 13.57 9.70 163 254541 60308 64183720
Hypochloraemia 13.52 9.70 27 254677 2034 64241994
Herpes simplex 13.49 9.70 13 254691 10523 64233505
Transaminases increased 13.42 9.70 112 254592 44482 64199546
Female orgasmic disorder 13.37 9.70 5 254699 28 64244000
Herbal interaction 13.36 9.70 12 254692 410 64243618
Somatic delusion 13.31 9.70 15 254689 675 64243353
Compulsions 13.31 9.70 11 254693 335 64243693
Hepatitis B 13.26 9.70 7 254697 7738 64236290
Electrocardiogram T wave abnormal 13.23 9.70 36 254668 3320 64240708
Breast enlargement 13.22 9.70 21 254683 1321 64242707
Exposure via breast milk 13.21 9.70 16 254688 778 64243250
Pulmonary microemboli 13.18 9.70 4 254700 10 64244018
Renal tubular necrosis 13.16 9.70 44 254660 22066 64221962
Back pain 13.06 9.70 832 253872 249339 63994689
Blood pressure systolic abnormal 13.04 9.70 12 254692 9930 64234098
Temporomandibular joint syndrome 13.01 9.70 36 254668 3352 64240676
Schizophreniform disorder 12.99 9.70 8 254696 151 64243877
Gait deviation 12.91 9.70 6 254698 62 64243966
Epistaxis 12.90 9.70 292 254412 97839 64146189
Tongue haematoma 12.87 9.70 9 254695 212 64243816
Product taste abnormal 12.85 9.70 26 254678 1977 64242051
Concomitant disease aggravated 12.83 9.70 16 254688 11526 64232502
Maternal drugs affecting foetus 12.83 9.70 23 254681 1597 64242431
Neoplasm malignant 12.81 9.70 52 254652 24636 64219392
Lack of spontaneous speech 12.80 9.70 9 254695 214 64243814
Substance use disorder 12.75 9.70 11 254693 356 64243672
Squamous cell carcinoma 12.71 9.70 22 254682 13847 64230181
Feeling of despair 12.68 9.70 30 254674 2538 64241490
Blood triglycerides increased 12.68 9.70 122 254582 18744 64225284
Change of bowel habit 12.61 9.70 29 254675 2409 64241619
Abnormal uterine bleeding 12.57 9.70 16 254688 819 64243209
Dermatitis acneiform 12.56 9.70 9 254695 8434 64235594
Intestinal perforation 12.53 9.70 26 254678 15287 64228741
Gastrointestinal perforation 12.52 9.70 3 254701 5421 64238607
Anuria 12.52 9.70 36 254668 18928 64225100
Atrial septal defect 12.50 9.70 23 254681 1630 64242398
Vomiting 12.43 9.70 2412 252292 548705 63695323
Genital anaesthesia 12.42 9.70 4 254700 13 64244015
Blood lactate dehydrogenase increased 12.41 9.70 78 254626 33000 64211028
Psychiatric decompensation 12.41 9.70 29 254675 2434 64241594
Rhabdomyolysis 12.41 9.70 461 254243 91265 64152763
Libido increased 12.41 9.70 24 254680 1766 64242262
Abnormal loss of weight 12.39 9.70 60 254644 7340 64236688
Orthostatic hypotension 12.33 9.70 256 254448 46482 64197546
Energy increased 12.32 9.70 31 254673 2727 64241301
Malpositioned teeth 12.31 9.70 5 254699 36 64243992
Fear of injection 12.29 9.70 4 254700 5908 64238120
Reflux laryngitis 12.27 9.70 6 254698 70 64243958
Acute generalised exanthematous pustulosis 12.25 9.70 23 254681 14035 64229993
Implant site irritation 12.22 9.70 7 254697 115 64243913
Alcohol use 12.21 9.70 43 254661 4559 64239469
Serositis 12.20 9.70 15 254689 741 64243287
Alveolar bone resorption 12.20 9.70 6 254698 71 64243957
Bankruptcy 12.20 9.70 5 254699 37 64243991
Hepatic steatosis 12.19 9.70 181 254523 30826 64213202
Blood ethanol increased 12.18 9.70 14 254690 644 64243384
Ectopic pregnancy 12.12 9.70 22 254682 1542 64242486
Increased appetite 12.09 9.70 75 254629 10071 64233957
Trichotillomania 12.04 9.70 8 254696 173 64243855
Hepatic lesion 12.00 9.70 4 254700 5820 64238208
Head discomfort 11.99 9.70 84 254620 11750 64232278
Pelvic pain 11.98 9.70 79 254625 10831 64233197
Haematochezia 11.98 9.70 187 254517 66186 64177842
Gait disturbance 11.94 9.70 811 253893 171344 64072684
Blood urea increased 11.93 9.70 114 254590 44039 64199989
Amniotic cavity infection 11.92 9.70 15 254689 759 64243269
Compulsive sexual behaviour 11.88 9.70 9 254695 241 64243787
Drooling 11.86 9.70 47 254657 5272 64238756
Atrioventricular dissociation 11.81 9.70 10 254694 315 64243713
Lymphomatoid papulosis 11.79 9.70 10 254694 316 64243712
Hypersensitivity vasculitis 11.74 9.70 6 254698 6755 64237273
Alcohol abuse 11.74 9.70 44 254660 4808 64239220
Oesophageal ulcer haemorrhage 11.72 9.70 13 254691 575 64243453
Drug level increased 11.70 9.70 195 254509 34001 64210027
Suspiciousness 11.66 9.70 13 254691 578 64243450
Lactate pyruvate ratio increased 11.64 9.70 6 254698 79 64243949
Periorbital swelling 11.62 9.70 24 254680 1852 64242176
Breast discomfort 11.60 9.70 10 254694 323 64243705
Vasodilation procedure 11.55 9.70 5 254699 43 64243985
Hippocampal atrophy 11.55 9.70 3 254701 3 64244025
Nasal cavity packing 11.55 9.70 3 254701 3 64244025
Barbiturates positive 11.55 9.70 3 254701 3 64244025
Large intestine perforation 11.54 9.70 20 254684 12584 64231444
Vaginal haemorrhage 11.51 9.70 122 254582 19222 64224806
Mallory-Weiss syndrome 11.50 9.70 29 254675 2554 64241474
Pneumothorax 11.50 9.70 53 254651 24245 64219783
Ejaculation disorder 11.47 9.70 12 254692 496 64243532
Gambling disorder 11.46 9.70 24 254680 1870 64242158
Polymenorrhagia 11.45 9.70 5 254699 44 64243984
Lymphoproliferative disorder 11.44 9.70 3 254701 5100 64238928
Dry mouth 11.40 9.70 316 254388 60102 64183926
Serum ferritin increased 11.37 9.70 10 254694 8458 64235570
Aphthous ulcer 11.35 9.70 21 254683 12885 64231143
Unmasking of previously unidentified disease 11.31 9.70 22 254682 1625 64242403
Panniculitis 11.31 9.70 11 254693 8868 64235160
Grip strength decreased 11.29 9.70 18 254686 11706 64232322
Delusional perception 11.27 9.70 10 254694 336 64243692
Purple glove syndrome 11.26 9.70 9 254695 261 64243767
Vanishing twin syndrome 11.25 9.70 6 254698 85 64243943
Sleep inertia 11.23 9.70 4 254700 19 64244009
Tongue discolouration 11.21 9.70 34 254670 3334 64240694
Hippocampal sclerosis 11.19 9.70 7 254697 136 64243892
Poor personal hygiene 11.14 9.70 12 254692 513 64243515
Gastric hypomotility 11.14 9.70 7 254697 137 64243891
Maternal condition affecting foetus 11.14 9.70 7 254697 137 64243891
Drug tolerance increased 11.14 9.70 13 254691 608 64243420
Oedema 11.13 9.70 277 254427 91658 64152370
Liver function test increased 11.13 9.70 74 254630 30896 64213132
Abscess 11.10 9.70 39 254665 19265 64224763
Shoplifting 11.09 9.70 3 254701 4 64244024
Metastases to central nervous system 11.06 9.70 24 254680 13888 64230140
Duplicate therapy error 11.03 9.70 8 254696 200 64243828
Obesity 11.01 9.70 127 254577 20435 64223593
Autoscopy 10.99 9.70 5 254699 49 64243979
Musculoskeletal stiffness 10.98 9.70 387 254317 122819 64121209
Gun shot wound 10.96 9.70 17 254687 1047 64242981
Multiple-drug resistance 10.95 9.70 6 254698 6496 64237532
Rash erythematous 10.94 9.70 131 254573 48502 64195526
Osteomyelitis 10.90 9.70 64 254640 27523 64216505
Platelet aggregation decreased 10.90 9.70 5 254699 50 64243978
Dyspraxia 10.89 9.70 9 254695 274 64243754
Delusion of reference 10.88 9.70 7 254697 143 64243885
Renal tubular disorder 10.88 9.70 5 254699 5982 64238046
Hepatotoxicity 10.87 9.70 103 254601 39859 64204169
Body temperature decreased 10.87 9.70 59 254645 25869 64218159
Slow response to stimuli 10.87 9.70 21 254683 1544 64242484
Premature baby 10.86 9.70 33 254671 3239 64240789
Blood pressure systolic increased 10.83 9.70 134 254570 49319 64194709
Respiratory dyskinesia 10.81 9.70 5 254699 51 64243977
Gastrointestinal haemorrhage 10.81 9.70 420 254284 131892 64112136
Product monitoring error 10.80 9.70 4 254700 5450 64238578
Cytomegalovirus chorioretinitis 10.80 9.70 3 254701 4909 64239119
Implant site extravasation 10.77 9.70 14 254690 732 64243296
Myocardial infarction 10.74 9.70 540 254164 165281 64078747
Mixed dementia 10.70 9.70 9 254695 281 64243747
Incontinence 10.67 9.70 83 254621 11998 64232030
Catheterisation cardiac 10.67 9.70 3 254701 4870 64239158
Merycism 10.63 9.70 8 254696 212 64243816
Cardiac failure chronic 10.62 9.70 12 254692 9029 64234999
Transfusion 10.58 9.70 36 254668 17958 64226070
Coprolalia 10.56 9.70 5 254699 54 64243974
Dementia 10.56 9.70 127 254577 20639 64223389
Appetite disorder 10.54 9.70 52 254652 6409 64237619
Amnestic disorder 10.52 9.70 12 254692 547 64243481
Hypokinesia 10.51 9.70 106 254598 16490 64227538
Deprescribing error 10.46 9.70 4 254700 24 64244004
Sickle cell anaemia with crisis 10.41 9.70 4 254700 5328 64238700
Nervous system disorder 10.40 9.70 138 254566 22940 64221088
Stoma site infection 10.38 9.70 18 254686 1217 64242811
Bone pain 10.38 9.70 129 254575 47443 64196585
Self-medication 10.37 9.70 38 254666 4107 64239921
Night sweats 10.36 9.70 200 254504 35846 64208182
Tendonitis 10.35 9.70 43 254661 20239 64223789
Painful erection 10.35 9.70 7 254697 156 64243872
Foetal exposure during pregnancy 10.34 9.70 40 254664 4436 64239592
Factor XIII Inhibition 10.33 9.70 4 254700 25 64244003
Sciatica 10.32 9.70 43 254661 20221 64223807
Retroperitoneal fibrosis 10.25 9.70 12 254692 563 64243465
Sluggishness 10.24 9.70 47 254657 5623 64238405
Acanthosis nigricans 10.20 9.70 7 254697 160 64243868
Poverty of speech 10.18 9.70 12 254692 567 64243461
Hypersensitivity pneumonitis 10.18 9.70 32 254672 3200 64240828
Blood citric acid increased 10.18 9.70 5 254699 59 64243969
Stubbornness 10.15 9.70 9 254695 302 64243726
Premature labour 10.15 9.70 58 254646 7562 64236466
Snoring 10.14 9.70 41 254663 4641 64239387
Pelvic inflammatory disease 10.14 9.70 18 254686 1240 64242788
Oesophageal candidiasis 10.14 9.70 10 254694 8007 64236021
Pneumatosis intestinalis 10.08 9.70 4 254700 5225 64238803
Alcohol intolerance 10.08 9.70 10 254694 388 64243640
Seizure like phenomena 10.08 9.70 21 254683 1631 64242397
Right ventricular failure 10.06 9.70 47 254657 21424 64222604
Hypokalaemia 10.06 9.70 583 254121 121320 64122708
Antidepressant drug level decreased 10.03 9.70 3 254701 7 64244021
Pancreatic enzymes decreased 10.03 9.70 3 254701 7 64244021
Logorrhoea 9.98 9.70 37 254667 4022 64240006
Coronary arterial stent insertion 9.96 9.70 5 254699 5687 64238341
Premature rupture of membranes 9.95 9.70 35 254669 3709 64240319
Gallbladder disorder 9.95 9.70 107 254597 16923 64227105
Anal abscess 9.92 9.70 9 254695 7499 64236529
Medication error 9.90 9.70 263 254441 49703 64194325
Exposure via ingestion 9.89 9.70 42 254662 4860 64239168
Leukaemoid reaction 9.88 9.70 9 254695 313 64243715
Pulmonary mass 9.88 9.70 55 254649 23961 64220067
Skin fissures 9.76 9.70 16 254688 10290 64233738
Loss of personal independence in daily activities 9.76 9.70 364 254340 72090 64171938
Flight of ideas 9.73 9.70 13 254691 698 64243330
Visceral congestion 9.71 9.70 14 254690 808 64243220

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature baby 28.84 19.20 34 2128 3796 78720
Agitation neonatal 25.34 19.20 52 2110 579 81937
Human herpesvirus 6 infection 20.80 19.20 15 2147 45 82471

Pharmacologic Action:

SourceCodeDescription
ATC N06AB06 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:50949 SSRI
FDA EPC N0000175696 Serotonin Reuptake Inhibitor
FDA MoA N0000182137 Cytochrome P450 2D6 Inhibitors
MeSH PA D000928 Antidepressive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D017367 Serotonin Uptake Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Premenstrual dysphoric disorder indication 596004
Social phobia indication 25501002 DOID:11257
Depressive disorder indication 35489007
Posttraumatic stress disorder indication 47505003 DOID:2055
Obsessive-compulsive disorder indication 191736004 DOID:10933
Panic disorder indication 371631005 DOID:594
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Seasonal affective disorder off-label use 247803002
Cholestatic pruritus off-label use 707150004
Suicidal thoughts contraindication 6471006
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Upper gastrointestinal hemorrhage contraindication 37372002
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Blood coagulation disorder contraindication 64779008 DOID:1247
Weight loss contraindication 89362005
Hyponatremia contraindication 89627008
Seizure disorder contraindication 128613002
Mania contraindication 231494001
Hypomania contraindication 231496004
Disease of liver contraindication 235856003 DOID:409
Serotonin syndrome contraindication 371089000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.61 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 9.54 CHEMBL CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 7.24 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel Ki 5.17 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Kd 6.38 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR Ki 6.11 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 5.67 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.25 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR Ki 6.86 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 7.08 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 6.13 PDSP
Muscarinic acetylcholine receptor M2 GPCR Ki 5.68 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 5.89 PDSP
Muscarinic acetylcholine receptor M4 GPCR Ki 5.85 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 5.72 PDSP
Alpha-2C adrenergic receptor GPCR Ki 6.19 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Kd 7.60 WOMBAT-PK
Cytochrome P450 2C19 Enzyme IC50 6 DRUG MATRIX
Melanocortin receptor 5 GPCR Ki 5.37 DRUG MATRIX
Alpha-2A adrenergic receptor GPCR Ki 6.97 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 6.48 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 5.89 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 9.07 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 7.11 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 7.24 CHEMBL
Transporter Transporter Ki 6.80 CHEMBL
Transcriptional activator protein luxR Unclassified IC50 4.57 CHEMBL
Sigma intracellular receptor 2 Unclassified Ki 5.28 CHEMBL

External reference:

IDSource
4020551 VUID
N0000148257 NUI
D00825 KEGG_DRUG
79559-97-0 SECONDARY_CAS_RN
4020394 VANDF
4020551 VANDF
C0074393 UMLSCUI
CHEBI:9123 CHEBI
SRE PDB_CHEM_ID
CHEMBL809 ChEMBL_ID
DB01104 DRUGBANK_ID
CHEMBL1709 ChEMBL_ID
D020280 MESH_DESCRIPTOR_UI
68617 PUBCHEM_CID
4798 IUPHAR_LIGAND_ID
5277 INN_ID
QUC7NX6WMB UNII
155137 RXNORM
169461 MMSL
39959 MMSL
5457 MMSL
83167 MMSL
d00880 MMSL
003629 NDDF
004615 NDDF
321958004 SNOMEDCT_US
372594008 SNOMEDCT_US
96211006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Zoloft HUMAN PRESCRIPTION DRUG LABEL 1 0049-0050 SOLUTION, CONCENTRATE 20 mg ORAL NDA 32 sections
Zoloft HUMAN PRESCRIPTION DRUG LABEL 1 0049-4900 TABLET, FILM COATED 50 mg ORAL NDA 32 sections
Zoloft HUMAN PRESCRIPTION DRUG LABEL 1 0049-4910 TABLET, FILM COATED 100 mg ORAL NDA 32 sections
Zoloft HUMAN PRESCRIPTION DRUG LABEL 1 0049-4960 TABLET, FILM COATED 25 mg ORAL NDA 32 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9580 TABLET, FILM COATED 100 mg ORAL ANDA 31 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9581 TABLET, FILM COATED 50 mg ORAL ANDA 31 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9582 TABLET, FILM COATED 25 mg ORAL ANDA 31 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0143-9654 TABLET, FILM COATED 100 mg ORAL ANDA 31 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0143-9655 TABLET, FILM COATED 50 mg ORAL ANDA 31 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0143-9656 TABLET, FILM COATED 25 mg ORAL ANDA 31 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0615-7989 TABLET, FILM COATED 25 mg ORAL ANDA 24 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0615-7990 TABLET, FILM COATED 50 mg ORAL ANDA 24 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0615-7991 TABLET, FILM COATED 100 mg ORAL ANDA 24 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0904-6924 TABLET, FILM COATED 25 mg ORAL ANDA 30 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0904-6925 TABLET, FILM COATED 50 mg ORAL ANDA 30 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0904-6926 TABLET, FILM COATED 100 mg ORAL ANDA 30 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10135-694 SOLUTION 20 mg ORAL ANDA 28 sections
Sertraline Hydrochloride Human Prescription Drug Label 1 13107-011 TABLET 25 mg ORAL ANDA 26 sections
Sertraline Hydrochloride Human Prescription Drug Label 1 13107-012 TABLET 50 mg ORAL ANDA 26 sections
Sertraline Hydrochloride Human Prescription Drug Label 1 13107-013 TABLET 100 mg ORAL ANDA 26 sections
ZOLOFT HUMAN PRESCRIPTION DRUG LABEL 1 16590-250 TABLET, FILM COATED 50 mg ORAL NDA 31 sections
ZOLOFT HUMAN PRESCRIPTION DRUG LABEL 1 16590-251 TABLET, FILM COATED 100 mg ORAL NDA 31 sections
SERTRALINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-416 TABLET 100 mg ORAL ANDA 25 sections
SERTRALINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-457 TABLET 50 mg ORAL ANDA 25 sections
SERTRALINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-700 TABLET 25 mg ORAL ANDA 25 sections
Sertraline Hydrochloride Human Prescription Drug Label 1 16714-601 SOLUTION 20 mg ORAL ANDA 30 sections
Sertraline Hydrochloride Human Prescription Drug Label 1 16714-611 TABLET, FILM COATED 25 mg ORAL ANDA 31 sections
Sertraline Hydrochloride Human Prescription Drug Label 1 16714-612 TABLET, FILM COATED 50 mg ORAL ANDA 31 sections
Sertraline Hydrochloride Human Prescription Drug Label 1 16714-613 TABLET, FILM COATED 100 mg ORAL ANDA 31 sections
SERTRALINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16729-215 TABLET, FILM COATED 25 mg ORAL ANDA 29 sections