citalopram 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
663 59729-33-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • citalopram
  • nitalapram
  • bonitrile
  • citalopram hydrobromide
A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.
  • Molecular weight: 324.40
  • Formula: C20H21FN2O
  • CLOGP: 3.13
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 36.26
  • ALOGS: -4.74
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O
20 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.03 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 12 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.64 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 12 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.20 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 33 hours Lombardo F, Berellini G, Obach RS
BA (Bioavailability) 100 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AKT2,AKT3,AXL,BRAF,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK12,MET,NTRK2,PDK2,PDK4,PRKDC,TEK,TGFBR1 23
kinase-selectivity-class EIF2AK3,PDK4 2
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.962 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
rat-kpuu-brain Rat brain Kpuu 0.320 % High 1

Approvals:

DateAgencyCompanyOrphan
July 17, 1998 FDA FOREST LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2076.01 9.40 2154 221601 142904 90261788
Toxicity to various agents 1638.33 9.40 2711 221044 285135 90119557
Drug abuse 1314.30 9.40 1298 222457 81049 90323643
Electrocardiogram QT prolonged 796.43 9.40 938 222817 71518 90333174
Overdose 776.82 9.40 1395 222360 156314 90248378
Pemphigus 741.75 9.40 13 223742 326851 90077841
Systemic lupus erythematosus 689.54 9.40 54 223701 361842 90042850
Hand deformity 675.69 9.40 11 223744 296351 90108341
Drug interaction 671.27 9.40 1841 221914 274612 90130080
Serotonin syndrome 652.47 9.40 623 223132 37264 90367428
Synovitis 606.85 9.40 57 223698 329695 90074997
Accidental overdose 582.46 9.40 514 223241 27759 90376933
Glossodynia 565.43 9.40 66 223689 321713 90082979
Intentional overdose 563.59 9.40 907 222848 92927 90311765
Anti-cyclic citrullinated peptide antibody positive 551.02 9.40 6 223749 236427 90168265
Duodenal ulcer perforation 513.93 9.40 6 223749 221282 90183410
Helicobacter infection 506.52 9.40 11 223744 226839 90177853
Suicide attempt 496.02 9.40 760 222995 74639 90330053
Pericarditis 493.53 9.40 48 223707 270103 90134589
Hyponatraemia 457.09 9.40 1015 222740 132523 90272169
Temperature regulation disorder 448.50 9.40 335 223420 14244 90390448
Wound 445.74 9.40 101 223654 302879 90101813
Suicidal ideation 439.49 9.40 711 223044 73144 90331548
Sopor 439.07 9.40 413 223342 24231 90380461
Hyperhidrosis 434.26 9.40 1007 222748 135298 90269394
Folliculitis 430.43 9.40 17 223738 204336 90200356
Agitation 397.93 9.40 645 223110 66453 90338239
Arthropathy 397.58 9.40 204 223551 366038 90038654
Muscle injury 396.57 9.40 8 223747 176646 90228046
Rheumatoid factor positive 392.64 9.40 6 223749 171644 90233048
Food allergy 382.89 9.40 389 223366 25089 90379603
Alopecia 363.73 9.40 412 223343 494659 89910033
Irritable bowel syndrome 339.42 9.40 53 223702 207395 90197297
Cardio-respiratory arrest 333.10 9.40 576 223179 62564 90342128
Impaired healing 325.09 9.40 88 223667 234111 90170581
Rheumatic fever 314.94 9.40 15 223740 153106 90251586
Intentional self-injury 310.99 9.40 373 223382 28961 90375731
Respiratory arrest 310.45 9.40 397 223358 32914 90371778
Sleep disorder due to general medical condition, insomnia type 300.97 9.40 3 223752 128691 90276001
Torsade de pointes 298.75 9.40 269 223486 14913 90389779
Discomfort 287.04 9.40 160 223595 274175 90130517
Tremor 285.70 9.40 930 222825 152243 90252449
Therapeutic product effect decreased 284.54 9.40 166 223589 277405 90127287
Drug ineffective 277.18 9.40 2145 221610 1382153 89022539
Psoriatic arthropathy 263.22 9.40 117 223638 228218 90176474
Swelling 261.16 9.40 394 223361 418664 89986028
Fall 258.05 9.40 2052 221703 479758 89924934
Fibromyalgia 256.82 9.40 94 223661 206175 90198517
Ill-defined disorder 255.56 9.40 70 223685 184821 90219871
Blister 253.64 9.40 158 223597 254840 90149852
Intentional product misuse 249.87 9.40 629 223126 88975 90315717
Immunodeficiency 244.67 9.40 407 223348 42827 90361865
Somnolence 242.38 9.40 1091 222664 207993 90196699
Stomatitis 238.19 9.40 197 223558 274501 90130191
Rash erythematous 229.55 9.40 501 223254 64603 90340089
Poisoning 228.02 9.40 232 223523 14985 90389707
Abdominal discomfort 225.10 9.40 531 223224 476797 89927895
C-reactive protein abnormal 221.50 9.40 27 223728 127402 90277290
Blood cholesterol increased 219.45 9.40 120 223635 207892 90196800
Type 2 diabetes mellitus 217.71 9.40 115 223640 203129 90201563
Cardiac arrest 214.74 9.40 658 223097 104277 90300415
Anxiety 209.74 9.40 1396 222359 308376 90096316
Maternal exposure during pregnancy 204.17 9.40 360 223395 359703 90044989
Drug intolerance 203.84 9.40 507 223248 447084 89957608
Off label use 198.18 9.40 1756 221999 1100496 89304196
Infusion related reaction 196.96 9.40 463 223292 416317 89988375
Panic attack 187.90 9.40 276 223479 26089 90378603
Foetal death 186.85 9.40 243 223512 20480 90384212
Seizure 184.80 9.40 807 222948 151822 90252870
Treatment failure 181.37 9.40 294 223461 303634 90101058
Facet joint syndrome 178.19 9.40 18 223737 98371 90306321
Hypercholesterolaemia 173.82 9.40 22 223733 100870 90303822
Disturbance in attention 173.48 9.40 369 223386 46740 90357952
C-reactive protein increased 171.37 9.40 119 223636 181270 90223422
Mydriasis 167.55 9.40 196 223559 14816 90389876
Foetal exposure during pregnancy 159.84 9.40 338 223417 42637 90362055
Sinusitis 158.96 9.40 385 223370 342703 90061989
Joint range of motion decreased 155.48 9.40 70 223685 135573 90269119
Irritability 154.70 9.40 299 223456 35363 90369329
Liver injury 154.48 9.40 117 223638 170450 90234242
Wound infection 153.29 9.40 37 223718 106365 90298327
Lip dry 149.63 9.40 33 223722 100922 90303770
Muscle twitching 148.00 9.40 236 223519 23966 90380726
Autoimmune disorder 144.43 9.40 12 223743 76732 90327960
Contraindicated product administered 142.25 9.40 367 223388 319772 90084920
Intentional product use issue 141.75 9.40 197 223558 216695 90187997
Peripheral swelling 140.26 9.40 535 223220 412571 89992121
Unresponsive to stimuli 139.67 9.40 298 223457 37823 90366869
Lower respiratory tract infection 138.96 9.40 254 223501 250405 90154287
Gait inability 137.11 9.40 97 223658 146359 90258333
Loss of consciousness 135.78 9.40 695 223060 139543 90265149
Myoclonus 135.64 9.40 200 223555 18968 90385724
Drug withdrawal syndrome 134.72 9.40 249 223506 28474 90376218
Akathisia 133.47 9.40 151 223604 11008 90393684
Withdrawal syndrome 132.76 9.40 216 223539 22308 90382384
Hallucination 131.55 9.40 410 223345 65549 90339143
Long QT syndrome 131.43 9.40 96 223659 3941 90400751
Restlessness 129.45 9.40 278 223477 35442 90369250
Nightmare 128.95 9.40 209 223546 21516 90383176
Aggression 124.85 9.40 231 223524 26437 90378255
Gastrointestinal disorder 121.26 9.40 285 223470 256402 90148290
Nasopharyngitis 118.00 9.40 560 223195 406544 89998148
Constipation 116.39 9.40 1130 222625 279265 90125427
Pulmonary fibrosis 116.29 9.40 60 223695 107443 90297249
Bruxism 116.11 9.40 92 223663 4271 90400421
Electrocardiogram QRS complex prolonged 115.54 9.40 115 223640 7233 90397459
Peripheral venous disease 115.49 9.40 32 223723 83889 90320803
Adjustment disorder with depressed mood 115.26 9.40 6 223749 56747 90347945
Coeliac disease 114.87 9.40 304 223451 44306 90360386
Joint swelling 113.98 9.40 751 223004 502549 89902143
Lung disorder 112.81 9.40 122 223633 149761 90254931
Muscle rigidity 112.54 9.40 157 223598 14152 90390540
Lower limb fracture 110.49 9.40 36 223719 84977 90319715
Mobility decreased 109.38 9.40 290 223465 250444 90154248
Accidental death 108.62 9.40 66 223689 1982 90402710
Product use in unapproved indication 107.38 9.40 446 223309 335790 90068902
Grip strength decreased 107.30 9.40 47 223708 92529 90312163
Disorientation 105.95 9.40 293 223462 43821 90360871
Haematemesis 104.90 9.40 247 223508 33479 90371213
Rash 104.75 9.40 1362 222393 794738 89609954
Injury 102.36 9.40 208 223547 197141 90207551
Small for dates baby 101.04 9.40 90 223665 4917 90399775
Infection 100.90 9.40 505 223250 361589 90043103
Syncope 100.82 9.40 616 223139 132047 90272645
Anorgasmia 100.16 9.40 44 223711 656 90404036
Liver disorder 97.76 9.40 93 223662 121176 90283516
Fluid retention 97.00 9.40 453 223302 87638 90317054
Liver function test increased 95.35 9.40 45 223710 84810 90319882
Myelosuppression 93.99 9.40 11 223744 53580 90351112
Lethargy 93.14 9.40 355 223400 62784 90341908
Exposure via ingestion 92.72 9.40 66 223689 2601 90402091
Depressed mood 91.80 9.40 303 223452 49919 90354773
Inappropriate antidiuretic hormone secretion 91.36 9.40 169 223586 19336 90385356
Depressed level of consciousness 91.22 9.40 389 223366 72395 90332297
Hip arthroplasty 91.03 9.40 37 223718 76171 90328521
Blepharospasm 91.00 9.40 14 223741 55431 90349261
Musculoskeletal stiffness 89.37 9.40 402 223353 296130 90108562
Onychomadesis 87.09 9.40 7 223748 45991 90358701
Dyskinesia 87.08 9.40 242 223513 36292 90368400
Live birth 85.78 9.40 44 223711 79063 90325629
Parkinsonism 85.78 9.40 137 223618 13928 90390764
Depression 84.62 9.40 1123 222632 299478 90105214
Galactorrhoea 84.55 9.40 79 223676 4593 90400099
Urticaria 84.36 9.40 441 223314 312293 90092399
Mania 82.63 9.40 135 223620 13989 90390703
Psychomotor hyperactivity 82.57 9.40 128 223627 12685 90392007
Bradycardia 81.44 9.40 416 223339 83431 90321261
Hyperreflexia 81.19 9.40 91 223664 6566 90398126
Knee arthroplasty 80.63 9.40 53 223702 83129 90321563
Alcoholism 80.35 9.40 52 223703 1748 90402944
Inflammation 79.82 9.40 204 223551 178388 90226304
Condition aggravated 79.28 9.40 1016 222739 594529 89810163
Sciatica 77.98 9.40 81 223674 101301 90303391
Wheezing 77.72 9.40 313 223442 237767 90166925
Oedema 77.59 9.40 245 223510 200050 90204642
Bone erosion 77.22 9.40 18 223737 53003 90351689
Product prescribing error 77.17 9.40 205 223550 29940 90374752
Ventricular tachycardia 76.89 9.40 181 223574 24527 90380165
Crying 76.71 9.40 185 223570 25460 90379232
Upper respiratory tract infection 75.94 9.40 560 223195 127758 90276934
Drug dependence 75.65 9.40 200 223555 29127 90375565
Nail disorder 75.03 9.40 26 223729 59041 90345651
Hypoglycaemia 74.56 9.40 356 223399 69492 90335200
Taste disorder 73.32 9.40 30 223725 61516 90343176
Red blood cell sedimentation rate increased 73.05 9.40 58 223697 82537 90322155
Dementia 72.31 9.40 173 223582 23688 90381004
Mood swings 71.45 9.40 158 223597 20544 90384148
Cognitive disorder 70.68 9.40 349 223406 69058 90335634
Pneumonia 70 9.40 1131 222624 636928 89767764
Coma 69.59 9.40 359 223396 72273 90332419
Night sweats 69.09 9.40 133 223622 128633 90276059
Hepatic enzyme increased 68.74 9.40 565 223190 360171 90044521
Bradyphrenia 68.21 9.40 89 223666 7523 90397169
Bradykinesia 68.17 9.40 84 223671 6704 90397988
Exostosis 68.17 9.40 23 223732 53111 90351581
Therapeutic product effect incomplete 67.73 9.40 248 223507 193648 90211044
Dizziness 67.69 9.40 1919 221836 587365 89817327
Adverse event 66.80 9.40 117 223638 117301 90287391
Therapy non-responder 66.76 9.40 149 223606 136555 90268137
Nicotine dependence 66.63 9.40 38 223717 1012 90403680
Respiratory disorder neonatal 66.32 9.40 42 223713 1359 90403333
Prescribed underdose 65.94 9.40 53 223702 74966 90329726
Osteoarthritis 65.35 9.40 255 223500 195475 90209217
Arthralgia 65.35 9.40 1445 222310 777077 89627615
Abnormal behaviour 65.30 9.40 161 223594 22467 90382225
Febrile neutropenia 63.95 9.40 190 223565 158159 90246533
Extrapyramidal disorder 63.86 9.40 131 223624 16172 90388520
Coma scale abnormal 63.69 9.40 74 223681 5552 90399140
Feeling abnormal 63.55 9.40 662 223093 166573 90238119
Road traffic accident 63.29 9.40 105 223650 107521 90297171
Loss of libido 62.28 9.40 40 223715 1327 90403365
Yawning 61.98 9.40 37 223718 1075 90403617
Self-injurious ideation 61.53 9.40 56 223699 3147 90401545
Generalised tonic-clonic seizure 61.49 9.40 208 223547 34695 90369997
Speech disorder 60.52 9.40 248 223507 45337 90359355
Thinking abnormal 60.50 9.40 106 223649 11626 90393066
Concussion 59.53 9.40 102 223653 10989 90393703
Anger 59.45 9.40 115 223640 13605 90391087
Ventricular septal defect 57.70 9.40 69 223686 5338 90399354
Obsessive-compulsive disorder 57.39 9.40 63 223692 4441 90400251
Sputum purulent 55.35 9.40 37 223718 1315 90403377
Suicidal behaviour 55.18 9.40 50 223705 2794 90401898
Back pain 55.09 9.40 1094 222661 316081 90088611
Macular degeneration 55.08 9.40 13 223742 37957 90366735
Sinus tachycardia 54.78 9.40 175 223580 28338 90376354
Lupus-like syndrome 54.72 9.40 26 223729 48820 90355872
Alcohol abuse 54.38 9.40 43 223712 1990 90402702
Hostility 54.30 9.40 45 223710 2228 90402464
Atrial septal defect 54.10 9.40 83 223672 8151 90396541
Product use issue 53.99 9.40 537 223218 329382 90075310
Laryngitis 53.89 9.40 29 223726 50724 90353968
Drug-induced liver injury 53.21 9.40 88 223667 90230 90314462
Psychotic disorder 53.17 9.40 184 223571 31046 90373646
Pulseless electrical activity 53.10 9.40 86 223669 8846 90395846
Drug tolerance decreased 52.99 9.40 8 223747 32122 90372570
General physical health deterioration 52.84 9.40 591 223164 354524 90050168
Stress 52.66 9.40 363 223392 81032 90323660
Apathy 52.14 9.40 96 223659 10944 90393748
Illness anxiety disorder 52.04 9.40 18 223737 134 90404558
Antidepressant drug level above therapeutic 51.92 9.40 25 223730 465 90404227
Balance disorder 51.48 9.40 413 223342 96667 90308025
Back injury 50.44 9.40 26 223729 46596 90358096
Labelled drug-drug interaction issue 50.42 9.40 43 223712 2215 90402477
Melaena 49.96 9.40 194 223561 34603 90370089
Hypotonia 49.79 9.40 96 223659 11330 90393362
Reversible cerebral vasoconstriction syndrome 49.59 9.40 56 223699 4074 90400618
Drug withdrawal syndrome neonatal 49.43 9.40 43 223712 2276 90402416
Emotional distress 49.10 9.40 200 223555 36462 90368230
Malignant neoplasm progression 48.57 9.40 121 223634 106749 90297943
Abnormal dreams 48.34 9.40 94 223661 11163 90393529
Hepatic cirrhosis 48.12 9.40 51 223704 63202 90341490
Vertigo 47.95 9.40 316 223439 69495 90335197
Psoriasis 47.95 9.40 567 223188 147187 90257505
Neonatal hypoxia 47.85 9.40 27 223728 704 90403988
Hypokinesia 47.77 9.40 114 223641 15583 90389109
Angiodermatitis 47.67 9.40 18 223737 177 90404515
Ventricular arrhythmia 47.53 9.40 56 223699 4265 90400427
Impulsive behaviour 47.16 9.40 37 223718 1693 90402999
Cholecystitis chronic 47.10 9.40 86 223669 9740 90394952
Restless legs syndrome 46.95 9.40 142 223613 22328 90382364
Calcium deficiency 46.37 9.40 33 223722 1300 90403392
Ventricular fibrillation 46.02 9.40 105 223650 13939 90390753
Urinary retention 45.95 9.40 200 223555 37544 90367148
Myocardial stunning 45.84 9.40 20 223735 293 90404399
Libido decreased 45.65 9.40 46 223709 2936 90401756
Dyspepsia 45.60 9.40 294 223461 197866 90206826
Labelled drug-drug interaction medication error 45.56 9.40 107 223648 14475 90390217
Alcohol use 45.25 9.40 36 223719 1681 90403011
Nervousness 44.99 9.40 185 223570 33871 90370821
Ulcer haemorrhage 44.70 9.40 6 223749 26315 90378377
Obsessive thoughts 44.03 9.40 24 223731 584 90404108
Brain injury 43.97 9.40 73 223682 7665 90397027
Cerebral vasoconstriction 43.97 9.40 31 223724 1203 90403489
Alcohol poisoning 43.91 9.40 37 223718 1875 90402817
Clonus 43.60 9.40 62 223693 5688 90399004
Tearfulness 43.01 9.40 56 223699 4724 90399968
Posturing 42.82 9.40 23 223732 543 90404149
Lip swelling 42.82 9.40 199 223556 38411 90366281
Disease progression 42.67 9.40 220 223535 156395 90248297
Libido increased 42.65 9.40 35 223720 1709 90402983
Secondary immunodeficiency 42.48 9.40 38 223717 2088 90402604
Hallucination, auditory 42.28 9.40 110 223645 15865 90388827
Rib deformity 41.36 9.40 18 223737 262 90404430
Panic reaction 40.49 9.40 54 223701 4663 90400029
Hyperprolactinaemia 40.34 9.40 58 223697 5375 90399317
Adrenal insufficiency 40.07 9.40 12 223743 29909 90374783
Neuroglycopenia 39.70 9.40 28 223727 1087 90403605
Maternal drugs affecting foetus 39.70 9.40 56 223699 5099 90399593
Dystonia 39.68 9.40 111 223644 16708 90387984
Paranoia 39.55 9.40 94 223661 12814 90391878
Musculoskeletal pain 39.44 9.40 254 223501 170997 90233695
Pancytopenia 39.29 9.40 158 223597 120105 90284587
Multiple sclerosis relapse 39.16 9.40 242 223513 52063 90352629
Post-traumatic neck syndrome 38.89 9.40 39 223716 2475 90402217
Onychomycosis 38.75 9.40 22 223733 37354 90367338
Maternal exposure timing unspecified 38.48 9.40 5 223750 22478 90382214
Hallucination, visual 38.40 9.40 135 223620 22957 90381735
Mental disorder 38.40 9.40 170 223585 32148 90372544
Respiratory disorder 38.32 9.40 63 223692 64753 90339939
Hallucinations, mixed 38.18 9.40 59 223696 5830 90398862
Walking aid user 38.12 9.40 20 223735 35486 90369206
Injection site reaction 37.51 9.40 110 223645 91970 90312722
Hypokalaemia 36.90 9.40 490 223265 130626 90274066
CFTR gene mutation 36.76 9.40 16 223739 233 90404459
Alcohol interaction 36.33 9.40 32 223723 1722 90402970
Septic shock 36.16 9.40 98 223657 84062 90320630
Homicidal ideation 35.93 9.40 32 223723 1748 90402944
Hypochloraemia 35.73 9.40 38 223717 2584 90402108
Angle closure glaucoma 35.68 9.40 39 223716 2736 90401956
Physical assault 35.68 9.40 24 223731 862 90403830
Blood pressure decreased 35.64 9.40 311 223444 74584 90330108
Blood cholesterol decreased 35.61 9.40 33 223722 1898 90402794
Catatonia 35.58 9.40 58 223697 5998 90398694
Disability 35.54 9.40 29 223726 40716 90363976
Congenital thrombocytopenia 35.50 9.40 11 223744 55 90404637
Cytomegalovirus infection 35.03 9.40 11 223744 26591 90378101
Rabbit syndrome 34.98 9.40 17 223738 323 90404369
Tachycardia 34.83 9.40 565 223190 157108 90247584
Neutropenia 34.74 9.40 371 223384 224533 90180159
Adverse reaction 34.56 9.40 15 223740 29697 90374995
Rectal atresia 34.53 9.40 8 223747 8 90404684
Sirenomelia 34.53 9.40 8 223747 8 90404684
Ductus arteriosus premature closure 34.25 9.40 18 223737 406 90404286
Suspected suicide 34.13 9.40 74 223681 9494 90395198
Selective eating disorder 33.89 9.40 33 223722 2020 90402672
Hypersensitivity 33.85 9.40 859 222896 453818 89950874
Fear 33.76 9.40 104 223651 16518 90388174
Activation syndrome 33.71 9.40 15 223740 231 90404461
Bipolar I disorder 33.50 9.40 33 223722 2049 90402643
Soft tissue injury 33.37 9.40 33 223722 2059 90402633
Hepatic function abnormal 33.37 9.40 39 223716 46249 90358443
Poor quality sleep 33.30 9.40 135 223620 24558 90380134
Mucosal inflammation 33.15 9.40 57 223698 57568 90347124
Photosensitivity reaction 33.04 9.40 108 223647 17699 90386993
Major depression 32.85 9.40 75 223680 9960 90394732
Cytokine release syndrome 32.73 9.40 14 223741 27959 90376733
Sternal fracture 32.73 9.40 38 223717 2849 90401843
Peripheral circulatory failure 32.70 9.40 29 223726 1575 90403117
Personality change 32.50 9.40 62 223693 7259 90397433
Palpitations 32.49 9.40 496 223259 136232 90268460
Toxicologic test abnormal 32.32 9.40 21 223734 711 90403981
Hospitalisation 32.10 9.40 185 223570 127915 90276777
Substance abuse 32.07 9.40 52 223703 5354 90399338
Initial insomnia 32.07 9.40 71 223684 9239 90395453
Pustular psoriasis 32.06 9.40 4 223751 18552 90386140
Hyperkinesia 31.97 9.40 31 223724 1888 90402804
Obesity 31.76 9.40 143 223612 105364 90299328
Product administration error 31.40 9.40 139 223616 26284 90378408
Delusion 31.34 9.40 90 223665 13750 90390942
Dysarthria 31.21 9.40 236 223519 54246 90350446
Head injury 31.16 9.40 156 223599 31032 90373660
Flat affect 31.09 9.40 29 223726 1682 90403010
Negative thoughts 31.07 9.40 24 223731 1073 90403619
Chronic sinusitis 31.06 9.40 10 223745 23792 90380900
Bezoar 31.02 9.40 36 223719 2698 90401994
Arthritis 30.94 9.40 264 223491 167051 90237641
Medication error 30.68 9.40 332 223423 84320 90320372
Orthostatic intolerance 30.68 9.40 26 223729 1328 90403364
Carcinoid heart disease 30.66 9.40 9 223746 36 90404656
Histrionic personality disorder 30.47 9.40 9 223746 37 90404655
Hypersomnia 30.06 9.40 119 223636 21412 90383280
Product substitution issue 29.70 9.40 105 223650 17903 90386789
Congenital pulmonary valve atresia 29.69 9.40 10 223745 68 90404624
Hypotension 29.69 9.40 1031 222724 324366 90080326
Craniofacial fracture 29.56 9.40 17 223738 460 90404232
Pruritus 29.47 9.40 1067 222688 540458 89864234
Sleep terror 29.33 9.40 45 223710 4419 90400273
Interstitial lung disease 29.18 9.40 94 223661 76311 90328381
Gestational diabetes 29.18 9.40 74 223681 10508 90394184
Potentiating drug interaction 28.99 9.40 51 223704 5611 90399081
Rash vesicular 28.95 9.40 5 223750 18192 90386500
Circulatory collapse 28.83 9.40 130 223625 24774 90379918
Premature delivery 28.65 9.40 32 223723 38730 90365962
Goitre 28.44 9.40 56 223699 6711 90397981
Atrioventricular block first degree 28.30 9.40 64 223691 8447 90396245
Asthma 28.09 9.40 790 222965 241370 90163322
Enzyme inhibition 28.09 9.40 8 223747 28 90404664
Anticholinergic syndrome 27.63 9.40 34 223721 2709 90401983
Vascular access site thrombosis 27.54 9.40 9 223746 55 90404637
Foot deformity 27.52 9.40 67 223688 59584 90345108
Nodal arrhythmia 27.45 9.40 24 223731 1279 90403413
Therapeutic response decreased 27.38 9.40 121 223634 89608 90315084
Sleep disorder 27.32 9.40 335 223420 197695 90206997
Tinnitus 27.15 9.40 191 223564 42911 90361781
Underdose 27.08 9.40 58 223697 53959 90350733
Pruritus allergic 26.82 9.40 27 223728 1721 90402971
Polyhydramnios 26.75 9.40 32 223723 2476 90402216
Mood altered 26.61 9.40 98 223657 17046 90387646
Post viral fatigue syndrome 26.61 9.40 13 223742 250 90404442
Drug eruption 26.43 9.40 29 223726 35378 90369314
Stiff person syndrome 26.41 9.40 16 223739 478 90404214
Mental impairment 26.31 9.40 96 223659 16624 90388068
Stupor 26.30 9.40 48 223707 5434 90399258
Hypervigilance 26.29 9.40 16 223739 482 90404210
Pain 26.28 9.40 2111 221644 994230 89410462
Drug ineffective for unapproved indication 26.15 9.40 81 223674 66563 90338129
Drug resistance 26.15 9.40 22 223733 30427 90374265
Dermatillomania 26.15 9.40 13 223742 260 90404432
Facial paralysis 25.99 9.40 91 223664 15443 90389249
Cardiospasm 25.90 9.40 37 223718 3409 90401283
Blood creatine phosphokinase increased 25.83 9.40 158 223597 33865 90370827
Neuroleptic malignant syndrome 25.75 9.40 89 223666 15007 90389685
Stoma site pain 25.72 9.40 24 223731 1393 90403299
Atrial tachycardia 25.70 9.40 50 223705 5940 90398752
Self esteem decreased 25.65 9.40 19 223736 797 90403895
Foetal chromosome abnormality 25.65 9.40 7 223748 20 90404672
Tension headache 25.56 9.40 57 223698 7452 90397240
Tenosynovitis 25.52 9.40 3 223752 14564 90390128
Palmoplantar keratoderma 25.40 9.40 37 223718 3470 90401222
Normal newborn 25.31 9.40 13 223742 23349 90381343
Mental status changes 25.29 9.40 193 223562 44486 90360206
Anosmia 25.23 9.40 67 223688 9781 90394911
Bronchomalacia 25.23 9.40 12 223743 217 90404475
Hepatic steatosis 25.23 9.40 167 223588 36778 90367914
Hypoxic-ischaemic encephalopathy 25.15 9.40 43 223712 4625 90400067
Decreased immune responsiveness 24.98 9.40 62 223693 8686 90396006
Carotid artery occlusion 24.88 9.40 51 223704 6291 90398401
Multiple sclerosis 24.87 9.40 135 223620 27705 90376987
Bradycardia neonatal 24.79 9.40 21 223734 1072 90403620
Pupillary reflex impaired 24.76 9.40 31 223724 2514 90402178
Mutism 24.75 9.40 26 223729 1743 90402949
Neuropathy, ataxia, retinitis pigmentosa syndrome 24.60 9.40 8 223747 48 90404644
Pruritus genital 24.57 9.40 42 223713 4516 90400176
Hepatic cytolysis 24.57 9.40 24 223731 30892 90373800
Muscle tightness 24.48 9.40 81 223674 13358 90391334
Urine abnormality 24.42 9.40 57 223698 7680 90397012
Vascular access site infection 24.34 9.40 9 223746 83 90404609
Diaphragmatic rupture 24.32 9.40 12 223743 236 90404456
Talipes 24.06 9.40 25 223730 1655 90403037
Respiratory tract infection 23.75 9.40 71 223684 59007 90345685
Rheumatoid nodule 23.74 9.40 10 223745 20156 90384536
Tardive dyskinesia 23.71 9.40 70 223685 10860 90393832
Carbuncle 23.55 9.40 23 223732 1413 90403279
Respiratory failure 23.47 9.40 417 223338 118001 90286691
Pneumocystis jirovecii pneumonia 23.46 9.40 12 223743 21604 90383088
Developmental hip dysplasia 23.44 9.40 24 223731 1561 90403131
Hypertonia 23.31 9.40 44 223711 5111 90399581
Depression suicidal 23.28 9.40 27 223728 2022 90402670
Postmortem blood drug level increased 23.27 9.40 17 223738 698 90403994
Optic ischaemic neuropathy 23.19 9.40 25 223730 1727 90402965
Orgasm abnormal 23.19 9.40 9 223746 96 90404596
Erythema 23.11 9.40 735 223020 228511 90176181
Drug hypersensitivity 22.89 9.40 924 222831 462685 89942007
Contusion 22.81 9.40 460 223295 250756 90153936
Prescribed overdose 22.74 9.40 353 223402 97272 90307420
Cystoid macular oedema 22.74 9.40 27 223728 2073 90402619
Red blood cell sedimentation rate abnormal 22.68 9.40 16 223739 24188 90380504
Gallbladder disorder 22.65 9.40 103 223652 19700 90384992
Joint destruction 22.63 9.40 3 223752 13284 90391408
Urethral haemorrhage 22.52 9.40 8 223747 65 90404627
Monoclonal immunoglobulin present 22.49 9.40 27 223728 2097 90402595
Musculoskeletal chest pain 22.47 9.40 117 223638 23633 90381059
Female genital tract fistula 22.46 9.40 8 223747 17860 90386832
Poor feeding infant 22.44 9.40 15 223740 533 90404159
Rhabdomyolysis 22.42 9.40 209 223546 51047 90353645
Loose tooth 22.20 9.40 36 223719 3707 90400985
Movement disorder 22.18 9.40 135 223620 28884 90375808
Basal ganglion degeneration 22.05 9.40 13 223742 369 90404323
Tachyphrenia 21.98 9.40 24 223731 1682 90403010
Transient ischaemic attack 21.97 9.40 182 223573 42994 90361698
Female sexual arousal disorder 21.96 9.40 7 223748 39 90404653
Dry mouth 21.89 9.40 321 223434 183738 90220954
Social avoidant behaviour 21.86 9.40 34 223721 3379 90401313
Infantile apnoea 21.84 9.40 21 223734 1266 90403426
Iris coloboma 21.81 9.40 7 223748 40 90404652
Hypotonia neonatal 21.78 9.40 22 223733 1408 90403284
Polyarthritis 21.76 9.40 9 223746 18341 90386351
International normalised ratio increased 21.75 9.40 195 223560 47121 90357571
Chronic fatigue syndrome 21.72 9.40 23 223732 1556 90403136
Urinary incontinence 21.67 9.40 163 223592 37403 90367289
Sleep disorder due to a general medical condition 21.64 9.40 49 223706 44689 90360003
Respiratory alkalosis 21.60 9.40 34 223721 3414 90401278
Infected dermal cyst 21.57 9.40 14 223741 473 90404219
Antidepressant drug level increased 21.56 9.40 13 223742 385 90404307
Cholecystectomy 21.54 9.40 71 223684 11684 90393008
Hypocoagulable state 21.48 9.40 23 223732 1576 90403116
Dehydration 21.35 9.40 630 223125 193817 90210875
Hypoaesthesia 21.17 9.40 602 223153 313608 90091084
Pulmonary valve stenosis congenital 21.17 9.40 10 223745 178 90404514
Heart rate increased 21.12 9.40 394 223361 112508 90292184
CYP3A4 polymorphism 21.07 9.40 8 223747 80 90404612
Haematotoxicity 20.95 9.40 3 223752 12532 90392160
Dysgeusia 20.87 9.40 210 223545 52350 90352342
Sedation 20.86 9.40 196 223559 47975 90356717
Caesarean section 20.78 9.40 96 223659 18481 90386211
Hepatotoxicity 20.75 9.40 52 223703 45790 90358902
Agonal rhythm 20.64 9.40 6 223749 23 90404669
Cerebrospinal fluid retention 20.64 9.40 8 223747 85 90404607
Joint dislocation 20.62 9.40 50 223705 44532 90360160
Sensory disturbance 20.57 9.40 84 223671 15329 90389363
Obstructive defaecation 20.51 9.40 11 223744 259 90404433
Pyrexia 20.48 9.40 1380 222375 659105 89745587
Heart rate decreased 20.40 9.40 212 223543 53293 90351399
Labyrinthitis 20.07 9.40 29 223726 2700 90401992
Acquired epileptic aphasia 20.03 9.40 4 223751 0 90404692
Vaginal haemorrhage 19.95 9.40 139 223616 31132 90373560
Stoma site dermatitis 19.91 9.40 11 223744 275 90404417
Thrombotic microangiopathy 19.87 9.40 7 223748 15736 90388956
Sudden cardiac death 19.85 9.40 26 223729 2206 90402486
Disturbance in sexual arousal 19.70 9.40 11 223744 281 90404411
Hypothalamo-pituitary disorder 19.67 9.40 26 223729 2226 90402466
Respiratory rate increased 19.64 9.40 85 223670 15916 90388776
Hypertonic bladder 19.52 9.40 37 223718 4311 90400381
Muscle tension dysphonia 19.45 9.40 11 223744 288 90404404
General symptom 19.43 9.40 6 223749 14662 90390030
Caput succedaneum 19.24 9.40 5 223750 11 90404681
Amputation stump pain 19.20 9.40 6 223749 31 90404661
Trismus 19.19 9.40 39 223716 4782 90399910
Abnormal weight gain 19.13 9.40 28 223727 2637 90402055
Post-traumatic stress disorder 19.09 9.40 48 223707 6780 90397912
Dysphoria 19.06 9.40 45 223710 6109 90398583
Retinal coloboma 19.04 9.40 6 223749 32 90404660
Sebaceous gland infection 19.01 9.40 9 223746 161 90404531
Panniculitis 19.00 9.40 6 223749 14452 90390240
Polydipsia 18.99 9.40 36 223719 4195 90400497
Rib fracture 18.97 9.40 121 223634 26314 90378378
Rhinitis 18.94 9.40 75 223680 13497 90391195
Subarachnoid haemorrhage 18.92 9.40 91 223664 17813 90386879
Pyelonephritis chronic 18.89 9.40 10 223745 229 90404463
Acute myeloid leukaemia 18.87 9.40 14 223741 20626 90384066
Areflexia 18.83 9.40 33 223722 3620 90401072
Psychiatric symptom 18.82 9.40 49 223706 7069 90397623
Palmar-plantar erythrodysaesthesia syndrome 18.74 9.40 25 223730 27998 90376694
Postmortem blood drug level 18.73 9.40 8 223747 111 90404581
Heavy menstrual bleeding 18.64 9.40 100 223655 20430 90384262
Meconium in amniotic fluid 18.63 9.40 11 223744 313 90404379
Visual field defect 18.61 9.40 49 223706 7117 90397575
Panic disorder 18.53 9.40 30 223725 3085 90401607
Illusion 18.44 9.40 19 223736 1245 90403447
No adverse event 18.22 9.40 96 223659 67886 90336806
Arrhythmia 18.21 9.40 172 223583 42160 90362532
Dyspnoea 18.20 9.40 1901 221854 879054 89525638
Gastrooesophageal reflux disease 18.11 9.40 295 223460 166042 90238650
Impaired self-care 18.01 9.40 22 223733 1740 90402952
Vision blurred 17.98 9.40 377 223378 109916 90294776
Bipolar II disorder 17.91 9.40 12 223743 428 90404264
Joint stiffness 17.83 9.40 116 223639 77926 90326766
Stoma site inflammation 17.82 9.40 15 223740 759 90403933
Decerebrate posture 17.82 9.40 8 223747 126 90404566
Product administered to patient of inappropriate age 17.77 9.40 37 223718 4616 90400076
Cardiac steatosis 17.67 9.40 6 223749 42 90404650
Gastritis 17.64 9.40 169 223586 41584 90363108
Dyslipidaemia 17.60 9.40 60 223695 10047 90394645
Deep vein thrombosis 17.58 9.40 321 223434 91299 90313393
Drug abuser 17.51 9.40 27 223728 2663 90402029
Sunburn 17.47 9.40 30 223725 3237 90401455
Anhedonia 17.45 9.40 65 223690 11366 90393326
Skin warm 17.42 9.40 50 223705 7637 90397055
Kinematic imbalances due to suboccipital strain 17.26 9.40 4 223751 4 90404688
Pulmonary valve disease 17.24 9.40 5 223750 19 90404673
Increased appetite 17.22 9.40 66 223689 11699 90392993
Meningitis streptococcal 17.21 9.40 8 223747 137 90404555
Incoherent 17.19 9.40 38 223717 4939 90399753
Retching 17.18 9.40 93 223662 19066 90385626
Pancreatitis relapsing 17.11 9.40 19 223736 1357 90403335
Back disorder 17.01 9.40 23 223732 25608 90379084
Swollen tongue 17.00 9.40 181 223574 45775 90358917
Hiatus hernia 16.93 9.40 114 223641 25247 90379445
Gastrointestinal procedural complication 16.92 9.40 12 223743 470 90404222
Biliary dyskinesia 16.80 9.40 26 223729 2573 90402119
Heterophoria 16.76 9.40 6 223749 50 90404642
Polymenorrhagia 16.76 9.40 6 223749 50 90404642
Injection site pain 16.69 9.40 315 223440 173384 90231308
Myositis 16.68 9.40 21 223734 24107 90380585
Respiratory acidosis 16.67 9.40 51 223704 8068 90396624
Differential white blood cell count abnormal 16.67 9.40 16 223739 962 90403730
Akinesia 16.66 9.40 21 223734 1715 90402977
Blood sodium decreased 16.60 9.40 121 223634 27492 90377200
Hip fracture 16.60 9.40 139 223616 32938 90371754
Atonic urinary bladder 16.56 9.40 8 223747 150 90404542
Hyporeflexia 16.55 9.40 24 223731 2242 90402450
Gastric polyps 16.51 9.40 36 223719 4636 90400056
Enterocolitis 16.43 9.40 3 223752 10487 90394205
Emotional disorder 16.41 9.40 77 223678 14920 90389772
Hippocampal sclerosis 16.33 9.40 7 223748 98 90404594
Hot flush 16.19 9.40 221 223534 59267 90345425
Accommodation disorder 16.16 9.40 11 223744 403 90404289
Tension 16.12 9.40 31 223724 3651 90401041
Morbid thoughts 16.11 9.40 14 223741 740 90403952
Cataract 16.05 9.40 108 223647 71984 90332708
Gastrointestinal stoma output abnormal 16.02 9.40 11 223744 409 90404283
Noninfective gingivitis 16.01 9.40 23 223732 2130 90402562
Burns second degree 15.98 9.40 22 223733 1958 90402734
Nausea 15.92 9.40 3040 220715 1107276 89297416
Psychomotor retardation 15.91 9.40 36 223719 4753 90399939
Nodal rhythm 15.89 9.40 21 223734 1797 90402895
Vertigo CNS origin 15.82 9.40 5 223750 27 90404665
Proctitis 15.79 9.40 9 223746 15250 90389442
Ataxia 15.79 9.40 87 223668 17955 90386737
Bronchial hyperreactivity 15.74 9.40 22 223733 1986 90402706
Facial bones fracture 15.74 9.40 31 223724 3716 90400976
Female orgasmic disorder 15.71 9.40 6 223749 61 90404631
Depressive symptom 15.67 9.40 38 223717 5247 90399445
Osmotic demyelination syndrome 15.66 9.40 16 223739 1038 90403654
Adrenergic syndrome 15.66 9.40 7 223748 109 90404583
Headache 15.64 9.40 2392 221363 860354 89544338
Respiratory depression 15.62 9.40 78 223677 15497 90389195
Transplant rejection 15.55 9.40 6 223749 12752 90391940
Intestinal obstruction 15.54 9.40 150 223605 36981 90367711
Blood ethanol increased 15.49 9.40 7 223748 112 90404580
Neoplasm progression 15.45 9.40 57 223698 44429 90360263
Hepatorenal syndrome 15.41 9.40 22 223733 2026 90402666
Facial pain 15.40 9.40 69 223686 13113 90391579
Lipoedema 15.38 9.40 10 223745 339 90404353
Aspiration 15.33 9.40 78 223677 15615 90389077
Indifference 15.32 9.40 8 223747 178 90404514
Underweight 15.26 9.40 18 223737 1372 90403320
Nasal polyps 15.25 9.40 4 223751 10876 90393816
Acidosis 15.13 9.40 67 223688 12669 90392023
Congestive hepatopathy 15.12 9.40 27 223728 3006 90401686
Cardiomegaly 15.08 9.40 89 223666 18836 90385856
Educational problem 15.07 9.40 12 223743 561 90404131
Blood osmolarity decreased 15.06 9.40 15 223740 944 90403748
Hyponatraemic syndrome 15.05 9.40 12 223743 562 90404130
Anaesthesia 15.03 9.40 11 223744 453 90404239
Social problem 14.99 9.40 17 223738 1242 90403450
Pulmonary embolism 14.94 9.40 426 223329 130394 90274298
Neonatal respiratory depression 14.93 9.40 8 223747 188 90404504
Gastrointestinal sounds abnormal 14.92 9.40 34 223721 4509 90400183
Neuropathy peripheral 14.88 9.40 243 223512 136727 90267965
Dysphemia 14.88 9.40 27 223728 3043 90401649
Appetite disorder 14.85 9.40 53 223702 9080 90395612
Overweight 14.83 9.40 40 223715 5894 90398798
Caudal regression syndrome 14.81 9.40 8 223747 191 90404501
Middle insomnia 14.81 9.40 81 223674 16670 90388022
Insomnia 14.81 9.40 984 222771 332490 90072202
Ear infection 14.80 9.40 106 223649 69669 90335023
Peritoneal perforation 14.80 9.40 7 223748 125 90404567
Pulmonary toxicity 14.77 9.40 5 223750 11526 90393166
Pupil fixed 14.76 9.40 22 223733 2106 90402586
Dysaesthesia 14.75 9.40 37 223718 5218 90399474
Exposure during pregnancy 14.75 9.40 725 223030 237685 90167007
Oral candidiasis 14.70 9.40 42 223713 35413 90369279
Conversion disorder 14.62 9.40 22 223733 2124 90402568
Loss of personal independence in daily activities 14.61 9.40 242 223513 135863 90268829
Menopause 14.59 9.40 28 223727 3293 90401399
Upper gastrointestinal haemorrhage 14.58 9.40 102 223653 22874 90381818
Haemorrhage intracranial 14.56 9.40 75 223680 15087 90389605
Blood creatine increased 14.53 9.40 44 223711 6923 90397769
Hyperventilation 14.51 9.40 43 223712 6685 90398007
Bronchopulmonary aspergillosis 14.50 9.40 5 223750 11393 90393299
Drug screen positive 14.49 9.40 30 223725 3727 90400965
Dissociative amnesia 14.48 9.40 5 223750 37 90404655
Catarrh 14.48 9.40 19 223736 1615 90403077
Reversible airways obstruction 14.48 9.40 21 223734 1962 90402730
Hip surgery 14.46 9.40 32 223723 4163 90400529
Osteitis 14.40 9.40 30 223725 3743 90400949
Metastases to liver 14.38 9.40 31 223724 28776 90375916
Pickwickian syndrome 14.37 9.40 10 223745 380 90404312
Hypocalcaemia 14.25 9.40 55 223700 42313 90362379
Fibrous histiocytoma 14.24 9.40 12 223743 608 90404084
Orthostatic hypotension 14.22 9.40 162 223593 41665 90363027
Drug level increased 14.11 9.40 117 223638 27645 90377047
Uterine enlargement 14.05 9.40 17 223738 1331 90403361
Dysponesis 14.04 9.40 5 223750 41 90404651
Fine motor skill dysfunction 14.02 9.40 37 223718 5382 90399310
Cerebral ventricular rupture 13.99 9.40 8 223747 214 90404478
Confusional state 13.98 9.40 1121 222634 385084 90019608
Activated partial thromboplastin time abnormal 13.95 9.40 7 223748 143 90404549
Micturition disorder 13.93 9.40 26 223729 2994 90401698
Lip pruritus 13.93 9.40 17 223738 1343 90403349
Reflexes abnormal 13.91 9.40 13 223742 756 90403936
Platelet count decreased 13.91 9.40 246 223509 136723 90267969
Borderline personality disorder 13.85 9.40 15 223740 1041 90403651
Post procedural haematuria 13.83 9.40 5 223750 43 90404649
Vaccination complication 13.82 9.40 15 223740 1044 90403648
Atrophic vulvovaginitis 13.80 9.40 20 223735 1867 90402825
Adjusted calcium decreased 13.80 9.40 8 223747 220 90404472
Disinhibition 13.71 9.40 15 223740 1053 90403639
Miosis 13.71 9.40 53 223702 9431 90395261
Noninfective encephalitis 13.69 9.40 11 223744 521 90404171
Dissociation 13.62 9.40 42 223713 6673 90398019
Haematoma 13.62 9.40 152 223603 38896 90365796
Finger deformity 13.61 9.40 39 223716 32858 90371834
Abdominal pain upper 13.55 9.40 677 223078 331997 90072695
Flatulence 13.52 9.40 159 223596 41208 90363484
Multiple drug therapy 13.45 9.40 43 223712 6966 90397726
Q fever 13.44 9.40 7 223748 155 90404537
Carotid artery thrombosis 13.41 9.40 3 223752 9089 90395603
Drug level above therapeutic 13.37 9.40 38 223717 5771 90398921
Tongue biting 13.31 9.40 21 223734 2112 90402580
Weight increased 13.30 9.40 871 222884 417056 89987636
Analgesic drug level above therapeutic 13.28 9.40 7 223748 159 90404533
Agitation neonatal 13.27 9.40 11 223744 545 90404147
Amniorrhexis 13.26 9.40 5 223750 49 90404643
Vertigo positional 13.25 9.40 27 223728 3317 90401375
Chronic obstructive pulmonary disease 13.24 9.40 256 223499 73573 90331119
On and off phenomenon 13.14 9.40 23 223732 2520 90402172
Apnoea 13.12 9.40 52 223703 9362 90395330
Blood alcohol increased 13.04 9.40 11 223744 558 90404134
Onychogryphosis 12.95 9.40 3 223752 3 90404689
Electrolyte substitution therapy 12.95 9.40 3 223752 3 90404689
Bisexuality 12.95 9.40 3 223752 3 90404689
Anti-neuronal antibody positive 12.95 9.40 3 223752 3 90404689
Microphthalmos 12.89 9.40 7 223748 169 90404523
Neurologic neglect syndrome 12.89 9.40 3 223752 8844 90395848
Memory impairment 12.87 9.40 603 223152 196641 90208051
Dermatitis allergic 12.86 9.40 80 223675 17247 90387445
Fracture 12.85 9.40 96 223659 21980 90382712
Immune thrombocytopenia 12.85 9.40 66 223689 13260 90391432
Skin laceration 12.85 9.40 109 223646 25926 90378766
Pneumonia viral 12.84 9.40 3 223752 8820 90395872
Blood prolactin increased 12.82 9.40 28 223727 3609 90401083
Hyperthermia 12.76 9.40 55 223700 10280 90394412
Self-medication 12.76 9.40 26 223729 3194 90401498
Sexual inhibition 12.75 9.40 4 223751 21 90404671
Immunisation 12.74 9.40 21 223734 2192 90402500
Neutrophil Pelger-Huet anomaly present 12.69 9.40 6 223749 107 90404585
Hepatic failure 12.67 9.40 152 223603 39576 90365116
Liver function test abnormal 12.67 9.40 186 223569 50659 90354033
Nystagmus 12.67 9.40 43 223712 7184 90397508
Antisocial behaviour 12.66 9.40 11 223744 581 90404111
Lipids increased 12.60 9.40 16 223739 1316 90403376
Choanal atresia 12.59 9.40 4 223751 22 90404670
Product quality issue 12.58 9.40 130 223625 79195 90325497
Incontinence 12.58 9.40 66 223689 13369 90391323
Neutrophil count abnormal 12.58 9.40 30 223725 4098 90400594
Tissue infiltration 12.55 9.40 13 223742 857 90403835
Creatinine renal clearance decreased 12.50 9.40 17 223738 18882 90385810
Cervix haematoma uterine 12.49 9.40 3 223752 4 90404688
Intra-abdominal haemorrhage 12.38 9.40 23 223732 2639 90402053
Blunted affect 12.36 9.40 8 223747 269 90404423
Decreased interest 12.34 9.40 31 223724 4376 90400316
Neonatal sinus tachycardia 12.30 9.40 4 223751 24 90404668
Umbilical artery vascular resistance increased 12.30 9.40 4 223751 24 90404668
Ureteric dilatation 12.28 9.40 5 223750 61 90404631
Cytopenia 12.26 9.40 15 223740 17434 90387258
Abortion induced 12.26 9.40 60 223695 11828 90392864
Therapy interrupted 12.21 9.40 73 223682 50035 90354657
Tic 12.19 9.40 19 223736 1892 90402800
Drug dose omission by device 12.16 9.40 5 223750 10226 90394466
Breath sounds abnormal 12.16 9.40 12 223743 15374 90389318
Phobia 12.12 9.40 9 223746 379 90404313
Antipsychotic drug level above therapeutic 12.12 9.40 16 223739 1368 90403324
Sexually inappropriate behaviour 12.07 9.40 6 223749 120 90404572
Non-cardiogenic pulmonary oedema 12.05 9.40 15 223740 1209 90403483
Aphasia 12.04 9.40 160 223595 42652 90362040
Diastolic hypertension 12.03 9.40 4 223751 26 90404666
Teratogenicity 12.00 9.40 8 223747 283 90404409
Drug dose titration not performed 11.99 9.40 12 223743 760 90403932
Marital problem 11.96 9.40 7 223748 196 90404496
Swelling face 11.96 9.40 274 223481 81078 90323614
Legal problem 11.90 9.40 4 223751 27 90404665
Radiculopathy 11.88 9.40 17 223738 18488 90386204
Drowning 11.83 9.40 10 223745 509 90404183
Dizziness postural 11.82 9.40 49 223706 9004 90395688
Angiopathy 11.80 9.40 35 223720 5445 90399247
Ceruloplasmin decreased 11.74 9.40 3 223752 6 90404686
Congenital megacolon 11.74 9.40 3 223752 6 90404686
Myocardial fibrosis 11.73 9.40 13 223742 926 90403766
Product monitoring error 11.73 9.40 31 223724 4513 90400179
Renal cyst 11.71 9.40 63 223692 12887 90391805
Parotid gland enlargement 11.69 9.40 13 223742 930 90403762
Skin ulcer 11.66 9.40 74 223681 50001 90354691
Therapy partial responder 11.62 9.40 23 223732 22020 90382672
Fear of falling 11.54 9.40 11 223744 656 90404036
Hyperacusis 11.50 9.40 23 223732 2788 90401904
Regressive behaviour 11.50 9.40 7 223748 211 90404481
Metastases to bone 11.49 9.40 29 223726 25476 90379216
Psychogenic seizure 11.43 9.40 19 223736 1997 90402695
Bone marrow failure 11.38 9.40 41 223714 32180 90372512
Gastrointestinal stoma complication 11.38 9.40 21 223734 2398 90402294
Renal aplasia 11.37 9.40 9 223746 417 90404275
Urinary tract infection 11.36 9.40 889 222866 304743 90099949
Homicide 11.33 9.40 8 223747 311 90404381
Hypopnoea 11.20 9.40 30 223725 4401 90400291
Opiates positive 11.18 9.40 8 223747 318 90404374
Hypercalcaemia 11.17 9.40 45 223710 34195 90370497
Congenital tricuspid valve incompetence 11.16 9.40 6 223749 142 90404550
Blood copper decreased 11.14 9.40 3 223752 8 90404684
Euphoric mood 11.13 9.40 34 223721 5375 90399317
Periventricular leukomalacia 11.12 9.40 7 223748 224 90404468
Pulmonary valve incompetence 11.12 9.40 17 223738 1664 90403028
Product complaint 11.09 9.40 64 223691 13436 90391256
Colostomy closure 11.08 9.40 6 223749 144 90404548
Merycism 11.07 9.40 8 223747 323 90404369
Agoraphobia 11.05 9.40 10 223745 558 90404134
Platelet function test abnormal 11.01 9.40 5 223750 81 90404611
Photophobia 11.01 9.40 90 223665 21179 90383513
Pneumonitis 10.95 9.40 64 223691 44106 90360586
Cushingoid 10.95 9.40 6 223749 10389 90394303
Anal atresia 10.94 9.40 9 223746 441 90404251
Foreign body in reproductive tract 10.92 9.40 14 223741 1163 90403529
Perinatal depression 10.92 9.40 12 223743 847 90403845
Oral neoplasm benign 10.88 9.40 3 223752 9 90404683
Narcolepsy 10.86 9.40 16 223739 1516 90403176
Airway remodelling 10.84 9.40 5 223750 84 90404608
Irregular sleep wake rhythm disorder 10.82 9.40 7 223748 235 90404457
Anal sphincter atony 10.81 9.40 8 223747 335 90404357
Peroneal nerve palsy 10.79 9.40 35 223720 5713 90398979
Allergic sinusitis 10.78 9.40 19 223736 2094 90402598
Generalised anxiety disorder 10.67 9.40 22 223733 2725 90401967
Ocular hyperaemia 10.66 9.40 45 223710 33753 90370939
Antisocial personality disorder 10.65 9.40 3 223752 10 90404682
Intracranial pressure increased 10.63 9.40 39 223716 6772 90397920
Systolic hypertension 10.62 9.40 10 223745 587 90404105
Life support 10.59 9.40 7 223748 244 90404448
Subdural haemorrhage 10.57 9.40 25 223730 3398 90401294
Electrocardiogram QT interval abnormal 10.57 9.40 7 223748 245 90404447
Oromandibular dystonia 10.54 9.40 10 223745 593 90404099
Wrong product administered 10.41 9.40 42 223713 7623 90397069
Posterior reversible encephalopathy syndrome 10.37 9.40 25 223730 22314 90382378
Chills 10.28 9.40 411 223344 131570 90273122
Extensor plantar response 10.25 9.40 15 223740 1412 90403280
Ear pain 10.24 9.40 92 223663 57610 90347082
Congenital lymphoedema 10.22 9.40 3 223752 12 90404680
Hypersexuality 10.22 9.40 10 223745 616 90404076
Vascular encephalopathy 10.21 9.40 11 223744 759 90403933
Pseudomonas infection 10.21 9.40 13 223742 14852 90389840
Persistent depressive disorder 10.20 9.40 14 223741 1243 90403449
Diabetes mellitus inadequate control 10.18 9.40 80 223675 18604 90386088
Contraindicated product prescribed 10.17 9.40 16 223739 1606 90403086
Thirst 10.14 9.40 72 223683 16223 90388469
Myocardial depression 10.12 9.40 10 223745 623 90404069
Chronic spontaneous urticaria 10.11 9.40 17 223738 1803 90402889
Death 10.10 9.40 1281 222474 455270 89949422
Hypogammaglobulinaemia 10.07 9.40 7 223748 10667 90394025
Basal ganglia infarction 10.05 9.40 9 223746 495 90404197
Bundle branch block right 10.05 9.40 33 223722 5420 90399272
Skin plaque 10.04 9.40 50 223705 9925 90394767
Affective disorder 10.03 9.40 42 223713 7751 90396941
Bleeding time prolonged 9.99 9.40 10 223745 633 90404059
CSF white blood cell count increased 9.96 9.40 4 223751 47 90404645
Neonatal respiratory distress syndrome 9.96 9.40 23 223732 3078 90401614
Brain death 9.94 9.40 27 223728 3994 90400698
Nephropathy toxic 9.91 9.40 10 223745 12678 90392014
Bulimia nervosa 9.90 9.40 9 223746 505 90404187
Vestibular neuronitis 9.88 9.40 11 223744 788 90403904
Blood bicarbonate decreased 9.87 9.40 23 223732 3096 90401596
Fatigue 9.87 9.40 3088 220667 1150935 89253757
Apraxia 9.85 9.40 19 223736 2243 90402449
Presyncope 9.85 9.40 121 223634 31684 90373008
Gastroenteritis 9.84 9.40 113 223642 29116 90375576
Suspected COVID-19 9.84 9.40 21 223734 2665 90402027
PCO2 decreased 9.83 9.40 14 223741 1286 90403406
Lichenification 9.83 9.40 9 223746 510 90404182
Steroid dependence 9.81 9.40 19 223736 2250 90402442
Joint ankylosis 9.81 9.40 14 223741 1289 90403403
Cerebellar atrophy 9.79 9.40 11 223744 796 90403896
Spinal cord injury lumbar 9.74 9.40 4 223751 50 90404642
Micturition urgency 9.72 9.40 54 223701 11179 90393513
Lower respiratory tract infection viral 9.71 9.40 12 223743 960 90403732
Gastric haemorrhage 9.71 9.40 39 223716 7064 90397628
Subclavian artery thrombosis 9.70 9.40 6 223749 186 90404506
Paresis 9.69 9.40 21 223734 2693 90401999
Decreased nasolabial fold 9.68 9.40 3 223752 15 90404677
Detoxification 9.68 9.40 3 223752 15 90404677
Feeling guilty 9.67 9.40 10 223745 658 90404034
Emotional poverty 9.65 9.40 8 223747 396 90404296
Multiple organ dysfunction syndrome 9.65 9.40 115 223640 68221 90336471
Adverse drug reaction 9.62 9.40 217 223538 116484 90288208
Substance abuser 9.56 9.40 6 223749 191 90404501
Ejection fraction decreased 9.54 9.40 33 223722 26220 90378472
Body dysmorphic disorder 9.53 9.40 8 223747 403 90404289
Fungal disease carrier 9.53 9.40 4 223751 53 90404639
Sedation complication 9.53 9.40 17 223738 16927 90387765
Oesophageal ulcer 9.45 9.40 31 223724 5088 90399604
Groin pain 9.45 9.40 57 223698 12156 90392536
Pain in extremity 9.43 9.40 971 222784 449558 89955134
Somnolence neonatal 9.43 9.40 5 223750 115 90404577
Spinal pain 9.43 9.40 69 223686 15698 90388994
Somatic symptom disorder 9.42 9.40 24 223731 3417 90401275

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1291.17 11.00 1366 101402 95099 42423468
Toxicity to various agents 1051.00 11.00 1934 100834 227202 42291365
Serotonin syndrome 621.19 11.00 508 102260 25337 42493230
Drug abuse 609.21 11.00 984 101784 103787 42414780
Suicidal ideation 512.54 11.00 606 102162 47555 42471012
Accidental overdose 393.65 11.00 410 102358 27920 42490647
Intentional overdose 379.10 11.00 540 102228 50916 42467651
Overdose 350.87 11.00 780 101988 104484 42414083
Suicide attempt 333.99 11.00 480 102288 45620 42472947
Paranoia 276.18 11.00 246 102522 13780 42504787
Tearfulness 256.14 11.00 138 102630 3362 42515205
Foetal exposure during pregnancy 249.84 11.00 426 102342 46885 42471682
Drug interaction 235.82 11.00 1266 101502 265733 42252834
Depression suicidal 234.84 11.00 127 102641 3118 42515449
Anxiety 230.01 11.00 718 102050 117842 42400725
Disinhibition 228.99 11.00 133 102635 3762 42514805
Psychiatric decompensation 226.80 11.00 136 102632 4086 42514481
Depressive symptom 225.02 11.00 131 102637 3722 42514845
Off label use 223.00 11.00 793 101975 637542 41881025
Obsessive-compulsive disorder 222.21 11.00 160 102608 6583 42511984
Electrocardiogram QT prolonged 212.52 11.00 400 102368 47545 42471022
Antipsychotic drug level below therapeutic 208.75 11.00 117 102651 3087 42515480
Therapeutic product effect variable 177.06 11.00 104 102664 3005 42515562
Psychomotor skills impaired 174.96 11.00 125 102643 5079 42513488
Intentional self-injury 171.07 11.00 197 102571 15005 42503562
Depression 169.62 11.00 622 102146 110741 42407826
Akathisia 168.47 11.00 164 102604 10287 42508280
Febrile neutropenia 166.35 11.00 123 102645 185580 42332987
Euphoric mood 159.48 11.00 129 102639 6324 42512243
Irritability 157.39 11.00 260 102508 27868 42490699
Aggression 156.84 11.00 336 102432 43827 42474740
Respiratory disorder neonatal 156.36 11.00 82 102686 1888 42516679
Drug withdrawal syndrome neonatal 149.62 11.00 107 102661 4354 42514213
Increased appetite 145.89 11.00 141 102627 8765 42509802
Confusional state 144.41 11.00 790 101978 166807 42351760
Psychotic disorder 136.04 11.00 249 102519 28959 42489608
Respiratory arrest 134.52 11.00 244 102524 28180 42490387
Poisoning 132.07 11.00 170 102598 14529 42504038
Agitation 130.61 11.00 396 102372 63918 42454649
Agitation neonatal 126.50 11.00 64 102704 1364 42517203
Depressed mood 109.71 11.00 200 102568 23184 42495383
Restlessness 109.00 11.00 227 102541 29022 42489545
Pyrexia 108.12 11.00 536 102232 393506 42125061
Small for dates baby 106.96 11.00 94 102674 5169 42513398
Loss of libido 106.10 11.00 75 102693 2995 42515572
Hypertonia neonatal 103.62 11.00 43 102725 567 42518000
Atrial septal defect 103.51 11.00 111 102657 7808 42510759
Disturbance in attention 100.06 11.00 222 102546 29644 42488923
Neonatal respiratory distress syndrome 98.58 11.00 84 102684 4429 42514138
Sexual dysfunction 95.74 11.00 99 102669 6676 42511891
Pneumonia 91.79 11.00 619 102149 421530 42097037
Tremor 91.65 11.00 469 102299 96460 42422107
Cardio-respiratory arrest 88.74 11.00 327 102441 58309 42460258
Intrusive thoughts 83.06 11.00 34 102734 432 42518135
Malignant neoplasm progression 81.04 11.00 85 102683 108315 42410252
Erectile dysfunction 81.00 11.00 183 102585 24730 42493837
Orgasmic sensation decreased 80.47 11.00 21 102747 49 42518518
Disease progression 79.76 11.00 140 102628 143516 42375051
Cytokine release syndrome 76.10 11.00 9 102759 44518 42474049
Septic shock 75.38 11.00 66 102702 91606 42426961
Acute kidney injury 74.69 11.00 549 102219 366788 42151779
Hallucination, auditory 74.68 11.00 131 102637 14733 42503834
Asphyxia 74.33 11.00 96 102672 8230 42510337
Interstitial lung disease 74.09 11.00 49 102719 78413 42440154
Sopor 73.78 11.00 122 102646 13080 42505487
Homicidal ideation 73.62 11.00 58 102710 2736 42515831
Psychomotor retardation 72.71 11.00 70 102698 4329 42514238
Sepsis 71.49 11.00 244 102524 199090 42319477
Hypospadias 71.07 11.00 63 102705 3504 42515063
Multiple organ dysfunction syndrome 70.41 11.00 78 102690 96957 42421610
Withdrawal syndrome 70.10 11.00 127 102641 14648 42503919
Anger 69.69 11.00 118 102650 12900 42505667
Myelosuppression 69.59 11.00 8 102760 40453 42478114
Libido decreased 69.36 11.00 73 102695 5025 42513542
Mental impairment 69.07 11.00 114 102654 12203 42506364
Maternal drugs affecting foetus 69.02 11.00 64 102704 3775 42514792
Diarrhoea 68.19 11.00 747 102021 460102 42058465
Prescribed overdose 67.65 11.00 116 102652 12811 42505756
Fall 66.89 11.00 861 101907 233659 42284908
Hepatic function abnormal 64.29 11.00 22 102746 51545 42467022
Drug ineffective 64.02 11.00 1103 101665 629094 41889473
Exposure during pregnancy 61.83 11.00 89 102679 8459 42510108
Neonatal hypoxia 61.30 11.00 29 102739 531 42518036
Obesity 60.45 11.00 127 102641 16332 42502235
Leukaemia 60.27 11.00 72 102696 5700 42512867
Muscle rigidity 60.22 11.00 106 102662 11953 42506614
Hallucination 59.82 11.00 286 102482 57221 42461346
Cryptorchism 59.80 11.00 45 102723 1982 42516585
Neonatal seizure 59.52 11.00 28 102740 506 42518061
Cytomegalovirus infection 59.19 11.00 5 102763 32301 42486266
Panic attack 58.97 11.00 100 102668 10945 42507622
Tachyphrenia 58.84 11.00 39 102729 1400 42517167
Somnolence 58.03 11.00 557 102211 140548 42378019
Sedation 56.61 11.00 182 102586 30293 42488274
Parkinsonism 56.47 11.00 96 102672 10527 42508040
Neutropenia 56.41 11.00 268 102500 199163 42319404
Temperature regulation disorder 56.27 11.00 35 102733 1124 42517443
Hallucination, visual 56.05 11.00 143 102625 20877 42497690
Homicide 55.79 11.00 32 102736 883 42517684
Drug screen positive 54.16 11.00 58 102710 4073 42514494
Somnambulism 53.93 11.00 53 102715 3362 42515205
Cardiac arrest 53.91 11.00 449 102319 108871 42409696
Impaired work ability 53.68 11.00 101 102667 11990 42506577
Mucosal inflammation 53.53 11.00 26 102742 49348 42469219
Accidental death 52.74 11.00 50 102718 3033 42515534
Dementia 52.40 11.00 120 102648 16360 42502207
Genital hypoaesthesia 51.19 11.00 20 102748 223 42518344
Platelet count decreased 50.08 11.00 169 102599 138412 42380155
Cardiac failure 49.98 11.00 115 102653 106741 42411826
Bradycardia neonatal 49.07 11.00 34 102734 1314 42517253
Parathyroid gland enlargement 49.01 11.00 18 102750 167 42518400
Neuropathy peripheral 48.96 11.00 108 102660 101745 42416822
Logorrhoea 48.93 11.00 46 102722 2761 42515806
Mood swings 48.57 11.00 81 102687 8745 42509822
Upper respiratory fungal infection 48.17 11.00 18 102750 176 42518391
Poverty of speech 47.84 11.00 19 102749 222 42518345
Anaemia 47.69 11.00 439 102329 279839 42238728
Myoclonus 47.49 11.00 118 102650 16947 42501620
Disturbance in sexual arousal 46.93 11.00 17 102751 151 42518416
Alcohol use 46.47 11.00 45 102723 2803 42515764
Hyperreflexia 46.16 11.00 50 102718 3557 42515010
Coma scale abnormal 46.12 11.00 56 102712 4509 42514058
Dyslipidaemia 46.01 11.00 82 102686 9336 42509231
Muscle twitching 45.73 11.00 93 102675 11687 42506880
Vasoplegia syndrome 45.31 11.00 43 102725 2612 42515955
Depressed level of consciousness 45.21 11.00 232 102536 47738 42470829
Alcohol poisoning 45.05 11.00 72 102696 7502 42511065
Hanging 44.81 11.00 17 102751 174 42518393
Haemangioma congenital 44.39 11.00 23 102745 516 42518051
Thrombocytopenia 44.24 11.00 273 102495 190006 42328561
Hyperhidrosis 43.68 11.00 370 102398 90142 42428425
Mydriasis 43.67 11.00 77 102691 8693 42509874
Neurodegenerative disorder 43.45 11.00 21 102747 404 42518163
Hypoglycaemia neonatal 42.89 11.00 38 102730 2112 42516455
Stomatitis 42.87 11.00 35 102733 50294 42468273
Atrial fibrillation 42.80 11.00 182 102586 139411 42379156
Loss of consciousness 42.72 11.00 374 102394 91980 42426587
Prescription drug used without a prescription 42.43 11.00 42 102726 2688 42515879
Disorientation 42.30 11.00 187 102581 36202 42482365
Anorgasmia 42.15 11.00 29 102739 1108 42517459
Hypomania 41.62 11.00 40 102728 2468 42516099
Electrocardiogram QRS complex prolonged 41.20 11.00 60 102708 5763 42512804
Pleural effusion 41.19 11.00 110 102658 97056 42421511
Drug hypersensitivity 41.03 11.00 114 102654 99275 42419292
Cogwheel rigidity 40.32 11.00 34 102734 1767 42516800
Adjustment disorder 40.05 11.00 30 102738 1312 42517255
Amnesia 40.02 11.00 155 102613 28282 42490285
Infantile apnoea 39.83 11.00 28 102740 1108 42517459
Medication error 39.77 11.00 172 102596 32982 42485585
Thrombosis 39.62 11.00 65 102703 68446 42450121
Derealisation 39.45 11.00 25 102743 830 42517737
Congenital ureteropelvic junction obstruction 39.34 11.00 12 102756 58 42518509
Hypertonia 39.03 11.00 54 102714 4947 42513620
Patent ductus arteriosus 39.02 11.00 45 102723 3431 42515136
Unresponsive to stimuli 38.50 11.00 164 102604 31239 42487328
Mania 38.28 11.00 81 102687 10466 42508101
Intentional product misuse 38.19 11.00 268 102500 61632 42456935
Dyskinesia 37.89 11.00 141 102627 25249 42493318
Renal failure 37.83 11.00 198 102570 143528 42375039
Pancytopenia 37.65 11.00 151 102617 117592 42400975
Drug withdrawal syndrome 37.60 11.00 126 102642 21423 42497144
Drug reaction with eosinophilia and systemic symptoms 37.43 11.00 28 102740 42047 42476520
Nightmare 37.40 11.00 139 102629 24873 42493694
Gun shot wound 37.39 11.00 26 102742 1011 42517556
Oedema peripheral 37.20 11.00 185 102583 135891 42382676
Rhinitis perennial 36.83 11.00 15 102753 188 42518379
Pneumonitis 36.81 11.00 28 102740 41690 42476877
Ventricular septal defect 36.60 11.00 49 102719 4350 42514217
Mental disorder 36.55 11.00 111 102657 17918 42500649
Bacterial infection 36.33 11.00 11 102757 27868 42490699
Forced expiratory volume 36.14 11.00 13 102755 113 42518454
Congenital hepatomegaly 35.76 11.00 9 102759 17 42518550
Weight increased 35.74 11.00 408 102360 107575 42410992
Renal impairment 35.48 11.00 141 102627 110087 42408480
Hyperventilation 35.39 11.00 41 102727 3141 42515426
Respiratory failure 35.14 11.00 174 102594 127958 42390609
Circulatory collapse 35.05 11.00 131 102637 23505 42495062
COVID-19 35.03 11.00 152 102616 115796 42402771
Bipolar disorder 34.66 11.00 45 102723 3877 42514690
Thinking abnormal 34.54 11.00 62 102706 7099 42511468
Apgar score low 34.34 11.00 24 102744 941 42517626
Hepatic cytolysis 34.25 11.00 11 102757 26833 42491734
Schizoaffective disorder 33.80 11.00 32 102736 1938 42516629
Seizure 33.18 11.00 440 102328 120121 42398446
Rheumatoid arthritis 33.16 11.00 32 102736 42408 42476159
Product use in unapproved indication 33.05 11.00 285 102483 184171 42334396
Negative thoughts 33.04 11.00 21 102747 701 42517866
Haemophagocytic lymphohistiocytosis 32.89 11.00 3 102765 18219 42500348
Failure to suspend medication 32.67 11.00 17 102751 385 42518182
Tumour lysis syndrome 32.36 11.00 7 102761 22224 42496343
Premature ejaculation 32.14 11.00 12 102756 117 42518450
Limb deformity 32.00 11.00 19 102749 560 42518007
Toxicologic test abnormal 31.87 11.00 18 102750 482 42518085
C-reactive protein increased 31.69 11.00 66 102702 63494 42455073
Newborn persistent pulmonary hypertension 31.61 11.00 12 102756 123 42518444
Drug resistance 31.50 11.00 22 102746 34226 42484341
Apathy 31.02 11.00 65 102703 8341 42510226
Diabetic hyperosmolar coma 31.02 11.00 18 102750 508 42518059
Burns second degree 30.97 11.00 54 102714 6042 42512525
Pneumocystis jirovecii pneumonia 30.94 11.00 11 102757 25170 42493397
Tardive dyskinesia 30.93 11.00 58 102710 6866 42511701
Selective eating disorder 30.93 11.00 29 102739 1735 42516832
Abnormal behaviour 30.79 11.00 136 102632 26315 42492252
Eyelid function disorder 30.76 11.00 13 102755 180 42518387
Clonus 30.50 11.00 40 102728 3480 42515087
Eosinophilia 30.43 11.00 21 102747 32878 42485689
Optic nerve hypoplasia 30.18 11.00 6 102762 0 42518567
Impulsive behaviour 29.96 11.00 33 102735 2392 42516175
Foot deformity 29.90 11.00 48 102720 5020 42513547
Hyperbilirubinaemia neonatal 29.61 11.00 21 102747 843 42517724
Delusion 29.20 11.00 90 102678 14644 42503923
Hypotonia neonatal 29.15 11.00 26 102742 1458 42517109
Catarrh 29.09 11.00 52 102716 5934 42512633
Torsade de pointes 28.90 11.00 64 102704 8530 42510037
Psychomotor hyperactivity 28.64 11.00 74 102694 10884 42507683
Bronchopulmonary aspergillosis 28.52 11.00 6 102762 19423 42499144
Myocardial fibrosis 28.40 11.00 24 102744 1251 42517316
Inappropriate antidiuretic hormone secretion 28.22 11.00 96 102672 16445 42502122
Constipation 28.07 11.00 253 102515 162038 42356529
Infection 28.03 11.00 157 102611 111911 42406656
Substance abuse 27.38 11.00 64 102704 8841 42509726
Infusion related reaction 27.18 11.00 67 102701 60739 42457828
Disseminated intravascular coagulation 26.96 11.00 13 102755 24781 42493786
Pruritus 26.59 11.00 309 102459 188462 42330105
Blood alcohol increased 26.34 11.00 17 102751 583 42517984
Toxic epidermal necrolysis 26.21 11.00 16 102752 26734 42491833
Psychiatric symptom 26.17 11.00 41 102727 4200 42514367
Radiologically isolated syndrome 26.04 11.00 6 102762 6 42518561
Steroid dependence 26.01 11.00 53 102715 6669 42511898
Panic reaction 25.75 11.00 26 102742 1704 42516863
Hypopnoea 25.73 11.00 58 102710 7824 42510743
Spontaneous penile erection 25.61 11.00 13 102755 279 42518288
Congenital hypercoagulation 25.15 11.00 5 102763 0 42518567
Influenza 25.14 11.00 72 102696 62103 42456464
Finnegan score increased 24.85 11.00 7 102761 24 42518543
Substance dependence 24.81 11.00 17 102751 645 42517922
Neuroleptic malignant syndrome 24.69 11.00 110 102658 21362 42497205
Decreased appetite 24.61 11.00 323 102445 192814 42325753
Swollen tongue 24.59 11.00 109 102659 21122 42497445
Synovitis 24.59 11.00 4 102764 15563 42503004
Neonatal pneumonia 24.58 11.00 10 102758 125 42518442
End stage renal disease 24.54 11.00 5 102763 16553 42502014
Cytopenia 24.49 11.00 6 102762 17491 42501076
Colitis 24.38 11.00 47 102721 46525 42472042
Cardiogenic shock 24.38 11.00 30 102738 35610 42482957
Congenital pulmonary hypertension 24.36 11.00 9 102759 85 42518482
Drug-induced liver injury 24.35 11.00 34 102734 38239 42480328
Prostate cancer 24.30 11.00 44 102724 44599 42473968
Ascites 24.14 11.00 64 102704 56614 42461953
Hypothyroidism 24.13 11.00 25 102743 32059 42486508
Tremor neonatal 24.08 11.00 15 102753 483 42518084
Neonatal disorder 23.99 11.00 18 102750 789 42517778
Wrong product administered 23.98 11.00 49 102719 6177 42512390
Hyperbilirubinaemia 23.72 11.00 10 102758 20625 42497942
Agoraphobia 23.71 11.00 12 102756 256 42518311
Pregnancy 23.71 11.00 12 102756 256 42518311
Kinematic imbalances due to suboccipital strain 23.62 11.00 6 102762 12 42518555
Mental status changes 23.48 11.00 178 102590 41937 42476630
Oedema 23.47 11.00 57 102711 51944 42466623
Lactic acidosis 23.41 11.00 46 102722 45215 42473352
Floppy infant 23.12 11.00 10 102758 147 42518420
Heat stroke 22.93 11.00 20 102748 1088 42517479
Tension 22.92 11.00 29 102739 2435 42516132
Dreamy state 22.70 11.00 6 102762 15 42518552
Major depression 22.61 11.00 44 102724 5354 42513213
Andropause 22.60 11.00 9 102759 106 42518461
Therapy partial responder 22.54 11.00 10 102758 20011 42498556
Maternal exposure during breast feeding 22.47 11.00 23 102745 1532 42517035
Dyspnoea 22.44 11.00 857 101911 441764 42076803
Peripheral swelling 22.28 11.00 127 102641 90143 42428424
Parosmia 22.27 11.00 54 102714 7637 42510930
Syncope 22.26 11.00 350 102418 99056 42419511
Rash maculo-papular 22.22 11.00 35 102733 37468 42481099
Bradyphrenia 22.18 11.00 43 102725 5219 42513348
Tic 22.09 11.00 28 102740 2355 42516212
Congenital hydronephrosis 21.98 11.00 17 102751 780 42517787
Insomnia 21.98 11.00 404 102364 117849 42400718
Poor quality sleep 21.90 11.00 61 102707 9379 42509188
Parkinson's disease 21.78 11.00 21 102747 1301 42517266
Hypertrophic cardiomyopathy 21.77 11.00 22 102746 1443 42517124
Gender dysphoria 21.69 11.00 7 102761 42 42518525
Abdominal distension 21.68 11.00 94 102674 71641 42446926
Orthostatic hypotension 21.65 11.00 137 102631 30433 42488134
Drug dependence 21.61 11.00 132 102636 28962 42489605
Congenital central nervous system anomaly 21.57 11.00 16 102752 689 42517878
Hyperphosphataemia 21.32 11.00 3 102765 13001 42505566
Pulmonary oedema 21.22 11.00 209 102559 53063 42465504
Muscle mass 21.18 11.00 11 102757 248 42518319
Postprandial hypoglycaemia 21.16 11.00 8 102760 81 42518486
Feeling abnormal 21.01 11.00 259 102509 69527 42449040
Hospitalisation 20.91 11.00 100 102668 74230 42444337
Pulmonary alveolar haemorrhage 20.90 11.00 5 102763 14811 42503756
Testicular atrophy 20.83 11.00 15 102753 617 42517950
Gingival pain 20.82 11.00 56 102712 8438 42510129
Cardiac murmur 20.80 11.00 73 102695 12702 42505865
Pulmonary artery stenosis congenital 20.79 11.00 14 102754 516 42518051
Bronchial disorder 20.79 11.00 21 102747 1377 42517190
Suicidal behaviour 20.79 11.00 22 102746 1524 42517043
Pilonidal cyst congenital 20.78 11.00 6 102762 23 42518544
Liver disorder 20.76 11.00 40 102728 39604 42478963
Hyponatraemic syndrome 20.75 11.00 10 102758 191 42518376
Self-medication 20.74 11.00 32 102736 3234 42515333
Antipsychotic drug level increased 20.74 11.00 39 102729 4627 42513940
Tinnitus 20.69 11.00 130 102638 28808 42489759
Appendicitis 20.66 11.00 12 102756 20601 42497966
Joint swelling 20.63 11.00 89 102679 67933 42450634
Resting tremor 20.58 11.00 18 102750 983 42517584
Persistent foetal circulation 20.54 11.00 12 102756 343 42518224
Decreased interest 20.47 11.00 29 102739 2716 42515851
Choanal atresia 20.39 11.00 5 102763 8 42518559
Opiates positive 20.39 11.00 14 102754 533 42518034
Hydrocele 20.32 11.00 28 102740 2555 42516012
Cough 20.15 11.00 305 102463 177798 42340769
Vestibular migraine 20.12 11.00 4 102764 0 42518567
Neglect of personal appearance 20.08 11.00 12 102756 358 42518209
Interstitial granulomatous dermatitis 20.03 11.00 10 102758 207 42518360
Epistaxis 19.93 11.00 88 102680 66738 42451829
Lymphoma 19.87 11.00 5 102763 14316 42504251
Exposure via ingestion 19.78 11.00 25 102743 2097 42516470
Nasopharyngitis 19.76 11.00 120 102648 83876 42434691
COVID-19 pneumonia 19.72 11.00 14 102754 21599 42496968
Acute myeloid leukaemia 19.55 11.00 15 102753 22241 42496326
Rhinorrhoea 19.48 11.00 29 102739 31765 42486802
Conduction disorder 19.36 11.00 27 102741 2491 42516076
Cardiotoxicity 19.17 11.00 50 102718 7395 42511172
Myelodysplastic syndrome 19.14 11.00 16 102752 22729 42495838
Intestinal congestion 19.06 11.00 5 102763 12 42518555
Sexual relationship change 19.06 11.00 5 102763 12 42518555
Pneumonia bacterial 19.03 11.00 7 102761 15685 42502882
Hepatitis C virus test positive 19.00 11.00 11 102757 309 42518258
Infant irritability 18.96 11.00 7 102761 66 42518501
Thrombotic microangiopathy 18.96 11.00 6 102762 14776 42503791
Glabellar reflex abnormal 18.73 11.00 6 102762 35 42518532
Dysphemia 18.68 11.00 23 102745 1879 42516688
Coordination abnormal 18.66 11.00 52 102716 7998 42510569
Diffuse large B-cell lymphoma stage II 18.45 11.00 6 102762 37 42518530
Duodenal ulcer perforation 18.29 11.00 22 102746 1754 42516813
Drug ineffective for unapproved indication 18.27 11.00 54 102714 46109 42472458
Myasthenia gravis 18.26 11.00 8 102760 16129 42502438
White blood cell count decreased 18.25 11.00 174 102594 110222 42408345
Incoherent 18.20 11.00 37 102731 4648 42513919
Liver function test increased 18.19 11.00 13 102755 19985 42498582
Alcohol interaction 18.10 11.00 24 102744 2111 42516456
Osmolar gap abnormal 18.06 11.00 6 102762 40 42518527
Pulse pressure decreased 18.04 11.00 9 102759 186 42518381
Dissociative disorder 17.81 11.00 14 102754 658 42517909
Leukopenia 17.81 11.00 266 102502 74480 42444087
Neonatal infection 17.76 11.00 12 102756 445 42518122
Alcoholism 17.63 11.00 28 102740 2902 42515665
Morbid thoughts 17.57 11.00 9 102759 197 42518370
Physical assault 17.47 11.00 17 102751 1065 42517502
Hand deformity 17.38 11.00 32 102736 3736 42514831
Urticaria 17.29 11.00 106 102662 73930 42444637
Neoplasm progression 17.24 11.00 27 102741 28973 42489594
Facial spasm 17.09 11.00 9 102759 209 42518358
Product use issue 16.84 11.00 112 102656 76639 42441928
Caesarean section 16.82 11.00 23 102745 2083 42516484
Brain oedema 16.82 11.00 81 102687 16246 42502321
Persistent depressive disorder 16.80 11.00 12 102756 487 42518080
Bone marrow failure 16.80 11.00 34 102734 33059 42485508
Hypogammaglobulinaemia 16.80 11.00 4 102764 11887 42506680
Systemic lupus erythematosus 16.69 11.00 55 102713 9269 42509298
Cognitive disorder 16.63 11.00 140 102628 34032 42484535
Dystonia 16.62 11.00 68 102700 12722 42505845
Rash 16.59 11.00 525 102243 276429 42242138
Sexually inappropriate behaviour 16.56 11.00 13 102755 610 42517957
Erythema 16.52 11.00 175 102593 108618 42409949
Salivary hypersecretion 16.51 11.00 61 102707 10882 42507685
Congenital pneumonia 16.49 11.00 7 102761 98 42518469
Blood catecholamines decreased 16.47 11.00 4 102764 6 42518561
Adrenal insufficiency 16.31 11.00 13 102755 18911 42499656
Blood bilirubin increased 16.30 11.00 50 102718 42202 42476365
Drug abuser 16.30 11.00 30 102738 3501 42515066
Patient elopement 16.23 11.00 8 102760 161 42518406
Hypophosphataemia 16.12 11.00 16 102752 20929 42497638
Gastrointestinal disorder 16.08 11.00 58 102710 46595 42471972
Hypercalcaemia 16.08 11.00 12 102756 18046 42500521
Cyanosis neonatal 16.00 11.00 10 102758 324 42518243
Tachycardia 15.96 11.00 337 102431 100750 42417817
Rectourethral fistula 15.93 11.00 5 102763 27 42518540
Tendon disorder 15.91 11.00 29 102739 3360 42515207
Abnormal dreams 15.91 11.00 50 102718 8221 42510346
Feeling of despair 15.90 11.00 17 102751 1191 42517376
Myositis 15.85 11.00 8 102760 14858 42503709
Delirium 15.84 11.00 195 102573 52324 42466243
Reduced facial expression 15.80 11.00 19 102749 1514 42517053
Alcohol abuse 15.75 11.00 32 102736 4017 42514550
Positive end-expiratory pressure 15.75 11.00 4 102764 8 42518559
Asthma 15.73 11.00 87 102681 62227 42456340
Transaminases increased 15.68 11.00 35 102733 32850 42485717
Xanthoma 15.65 11.00 7 102761 112 42518455
Oesophageal perforation 15.62 11.00 17 102751 1216 42517351
Bladder cancer 15.61 11.00 11 102757 17036 42501531
Dyspnoea exertional 15.59 11.00 65 102703 50083 42468484
Product dose omission issue 15.58 11.00 270 102498 154095 42364472
Anomaly of external ear congenital 15.54 11.00 7 102761 114 42518453
Treatment failure 15.50 11.00 88 102680 62536 42456031
Venoocclusive liver disease 15.50 11.00 3 102765 10299 42508268
Acute stress disorder 15.50 11.00 8 102760 178 42518389
Blood creatinine increased 15.49 11.00 180 102588 109823 42408744
Spermatozoa morphology abnormal 15.43 11.00 4 102764 9 42518558
Arthralgia 15.37 11.00 377 102391 204861 42313706
Arthropathy 15.37 11.00 30 102738 29567 42489000
Iron binding capacity total increased 15.36 11.00 5 102763 31 42518536
Vitamin D abnormal 15.35 11.00 6 102762 67 42518500
Osteonecrosis of jaw 15.30 11.00 14 102754 19035 42499532
Libido disorder 15.23 11.00 10 102758 353 42518214
Disorganised speech 15.22 11.00 18 102750 1410 42517157
Foetal heart rate deceleration abnormality 15.21 11.00 12 102756 567 42518000
Thrombotic stroke 15.20 11.00 9 102759 264 42518303
Red blood cell sedimentation rate decreased 15.14 11.00 9 102759 266 42518301
Visual snow syndrome 15.09 11.00 3 102765 0 42518567
Arachnoid cyst 15.08 11.00 9 102759 268 42518299
Acute psychosis 14.99 11.00 22 102746 2127 42516440
Haematuria 14.98 11.00 80 102688 57719 42460848
Lung disorder 14.97 11.00 62 102706 47861 42470706
Bladder trabeculation 14.96 11.00 5 102763 34 42518533
Economic problem 14.94 11.00 20 102748 1775 42516792
Slow response to stimuli 14.92 11.00 15 102753 978 42517589
Pernicious anaemia 14.90 11.00 7 102761 126 42518441
Bronchiectasis 14.83 11.00 84 102684 17935 42500632
Anaphylactic reaction 14.83 11.00 53 102715 42690 42475877
Bronchitis 14.78 11.00 61 102707 47140 42471427
Incontinence 14.74 11.00 43 102725 6787 42511780
Pneumonitis chemical 14.69 11.00 9 102759 281 42518286
Male sexual dysfunction 14.54 11.00 10 102758 382 42518185
Vestibular disorder 14.51 11.00 16 102752 1161 42517406
Osteoporosis 14.48 11.00 9 102759 14897 42503670
Hypertrophic scar 14.36 11.00 4 102764 13 42518554
Dysarthria 14.34 11.00 153 102615 39654 42478913
Gastrointestinal mucosal exfoliation 14.33 11.00 7 102761 138 42518429
Pseudohallucination 14.26 11.00 5 102763 40 42518527
Oesophageal carcinoma 14.22 11.00 3 102765 9693 42508874
Drug dispensed to wrong patient 14.20 11.00 11 102757 506 42518061
Brugada syndrome 14.18 11.00 15 102753 1038 42517529
Ejaculation delayed 14.17 11.00 9 102759 300 42518267
Intentional product misuse to child 14.15 11.00 5 102763 41 42518526
Anhidrosis 14.14 11.00 8 102760 215 42518352
Pleurothotonus 14.14 11.00 16 102752 1195 42517372
Postmortem blood drug level increased 14.12 11.00 11 102757 510 42518057
Memory impairment 14.09 11.00 184 102584 50038 42468529
JC virus CSF test positive 14.06 11.00 7 102761 144 42518423
Head circumference abnormal 14.05 11.00 5 102763 42 42518525
Oesophageal atresia 13.98 11.00 11 102757 518 42518049
Anaphylactic shock 13.88 11.00 22 102746 23495 42495072
Klebsiella infection 13.83 11.00 5 102763 11327 42507240
Toxic skin eruption 13.75 11.00 8 102760 13722 42504845
Graft versus host disease 13.71 11.00 7 102761 12918 42505649
Ventricular flutter 13.70 11.00 6 102762 91 42518476
Granulocytopenia 13.67 11.00 43 102725 7071 42511496
Hyperuricaemia 13.65 11.00 3 102765 9421 42509146
Eosinophil count decreased 13.60 11.00 28 102740 3548 42515019
Enterococcal infection 13.57 11.00 6 102762 12033 42506534
Productive cough 13.57 11.00 71 102697 51496 42467071
Coagulation factor increased 13.56 11.00 5 102763 47 42518520
Aspergillus infection 13.50 11.00 11 102757 15826 42502741
Teratogenicity 13.46 11.00 5 102763 48 42518519
Haematospermia 13.38 11.00 9 102759 331 42518236
Palmar-plantar erythrodysaesthesia syndrome 13.38 11.00 18 102750 20564 42498003
Genital anaesthesia 13.35 11.00 4 102764 18 42518549
Bacteraemia 13.34 11.00 25 102743 25015 42493552
Multiple drug therapy 13.32 11.00 15 102753 1114 42517453
Victim of chemical submission 13.27 11.00 7 102761 163 42518404
Open reduction of fracture 13.25 11.00 6 102762 99 42518468
Angioedema 13.24 11.00 55 102713 42422 42476145
Fear 13.23 11.00 57 102711 10908 42507659
Mood altered 13.15 11.00 56 102712 10662 42507905
Myocardial infarction 13.13 11.00 215 102553 123794 42394773
Hypoalbuminaemia 13.11 11.00 11 102757 15599 42502968
Benign prostatic hyperplasia 13.09 11.00 19 102749 21033 42497534
Rash erythematous 13.09 11.00 37 102731 32054 42486513
Cardiac death 13.08 11.00 15 102753 1137 42517430
Alcoholic psychosis 13.02 11.00 3 102765 3 42518564
Personality disorder 12.96 11.00 15 102753 1148 42517419
Electrocardiogram PR prolongation 12.95 11.00 14 102754 994 42517573
Renal disorder 12.89 11.00 32 102736 28948 42489619
Poor personal hygiene 12.87 11.00 9 102759 353 42518214
Micropenis 12.86 11.00 5 102763 55 42518512
Ventricular fibrillation 12.83 11.00 34 102734 30089 42488478
Generalised tonic-clonic seizure 12.79 11.00 108 102660 26271 42492296
Neurosis 12.79 11.00 7 102761 176 42518391
Rhinitis 12.76 11.00 60 102708 11917 42506650
Feeling guilty 12.61 11.00 9 102759 365 42518202
Carbon monoxide poisoning 12.53 11.00 6 102762 113 42518454
Coma 12.53 11.00 190 102578 53364 42465203
Pericardial effusion 12.50 11.00 33 102735 29242 42489325
Bradykinesia 12.49 11.00 35 102733 5401 42513166
Dissociation 12.45 11.00 28 102740 3770 42514797
Urinary retention 12.41 11.00 156 102612 42058 42476509
Wrong patient received product 12.41 11.00 27 102741 3556 42515011
Social avoidant behaviour 12.40 11.00 26 102742 3338 42515229
Staphylococcal sepsis 12.38 11.00 6 102762 11408 42507159
Drug intolerance 12.36 11.00 129 102639 80295 42438272
Injection site pain 12.35 11.00 85 102683 57713 42460854
Periventricular leukomalacia 12.29 11.00 6 102762 118 42518449
Hyponatraemia 12.27 11.00 326 102442 101136 42417431
CSF white blood cell count positive 12.26 11.00 4 102764 25 42518542
Opisthotonus 12.24 11.00 11 102757 623 42517944
Acute myocardial infarction 12.20 11.00 86 102682 58079 42460488
Transplant rejection 12.14 11.00 9 102759 13579 42504988
Male orgasmic disorder 12.11 11.00 6 102762 122 42518445
Wrong dose 12.11 11.00 14 102754 1070 42517497
Kidney transplant rejection 12.11 11.00 3 102765 8680 42509887
Haemolysis 12.11 11.00 4 102764 9585 42508982
Hypovitaminosis 12.04 11.00 12 102756 774 42517793
Vasculitis 12.04 11.00 16 102752 18378 42500189
Coagulation factor VII level decreased 11.98 11.00 6 102762 125 42518442
Product storage error 11.87 11.00 6 102762 11134 42507433
Radicular pain 11.85 11.00 6 102762 128 42518439
Palpitations 11.80 11.00 180 102588 50617 42467950
Migraine 11.78 11.00 103 102665 25311 42493256
Diabetic foetopathy 11.77 11.00 7 102761 207 42518360
Antipsychotic drug level above therapeutic 11.77 11.00 15 102753 1269 42517298
Ischaemic cerebral infarction 11.72 11.00 17 102751 1626 42516941
Angle closure glaucoma 11.72 11.00 14 102754 1108 42517459
Chills 11.71 11.00 158 102610 93908 42424659
Herpes zoster 11.71 11.00 51 102717 38826 42479741
Flashback 11.69 11.00 6 102762 132 42518435
Priapism 11.65 11.00 38 102730 6369 42512198
Blood calcium increased 11.64 11.00 3 102765 8451 42510116
HIV peripheral neuropathy 11.63 11.00 4 102764 30 42518537
Dissociative amnesia 11.59 11.00 5 102763 73 42518494
Blood phosphorus increased 11.58 11.00 8 102760 12517 42506050
Lacrimation increased 11.56 11.00 7 102761 11751 42506816
Oliguria 11.56 11.00 4 102764 9309 42509258
Adjusted calcium increased 11.52 11.00 4 102764 31 42518536
Illness 11.51 11.00 27 102741 24903 42493664
Legal problem 11.48 11.00 6 102762 137 42518430
Self-injurious ideation 11.44 11.00 18 102750 1850 42516717
Eye haematoma 11.41 11.00 6 102762 139 42518428
Type 2 diabetes mellitus 11.40 11.00 80 102688 18391 42500176
Personality change 11.39 11.00 35 102733 5684 42512883
Hypertransaminasaemia 11.39 11.00 4 102764 9223 42509344
Poor feeding infant 11.35 11.00 12 102756 830 42517737
Pulmonary valve stenosis 11.30 11.00 9 102759 431 42518136
Infertility 11.25 11.00 7 102761 225 42518342
Blood urea increased 11.15 11.00 41 102727 32752 42485815
Fluid retention 11.10 11.00 39 102729 31580 42486987
Tobacco user 11.09 11.00 10 102758 569 42517998
Emotional disorder 11.08 11.00 37 102731 6277 42512290

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3158.23 9.71 3399 265753 238982 110081165
Toxicity to various agents 2612.29 9.71 4395 264757 476160 109843987
Drug abuse 1842.79 9.71 2214 266938 175197 110144950
Serotonin syndrome 1201.76 9.71 1060 268092 58093 110262054
Overdose 988.71 9.71 1921 267231 231873 110088274
Electrocardiogram QT prolonged 918.01 9.71 1226 267926 107734 110212413
Drug interaction 822.54 9.71 2880 266272 497303 109822844
Suicidal ideation 768.38 9.71 1042 268110 92895 110227252
Intentional overdose 744.68 9.71 1233 267919 131268 110188879
Suicide attempt 617.29 9.71 989 268163 102405 110217742
Synovitis 478.03 9.71 54 269098 274038 110046109
Respiratory arrest 475.54 9.71 646 268506 57653 110262494
Hand deformity 463.77 9.71 15 269137 218491 110101656
Sopor 456.01 9.71 502 268650 36044 110284103
Cardio-respiratory arrest 421.52 9.71 895 268257 114941 110205206
Pemphigus 418.68 9.71 26 269126 214544 110105603
Agitation 394.73 9.71 859 268293 112192 110207955
Helicobacter infection 391.36 9.71 11 269141 181866 110138281
Intentional self-injury 389.27 9.71 468 268684 36961 110283186
Temperature regulation disorder 385.51 9.71 289 268863 12537 110307610
Off label use 367.87 9.71 2148 267004 1498037 108822110
Hyperhidrosis 366.28 9.71 1145 268007 186153 110133994
Poisoning 360.02 9.71 398 268754 28707 110291440
Pericarditis 340.44 9.71 61 269091 219053 110101094
Systemic lupus erythematosus 339.04 9.71 99 269053 254239 110065908
Hyponatraemia 335.12 9.71 1228 267924 216425 110103722
Duodenal ulcer perforation 330.90 9.71 27 269125 177673 110142474
Anxiety 323.87 9.71 1677 267475 343401 109976746
Glossodynia 323.61 9.71 72 269080 221932 110098215
Tremor 313.85 9.71 1144 268008 201088 110119059
Muscle injury 308.67 9.71 7 269145 140800 110179347
Torsade de pointes 296.87 9.71 319 268833 22281 110297866
Food allergy 287.77 9.71 296 268856 19652 110300495
Folliculitis 287.33 9.71 35 269117 167618 110152529
Rheumatoid factor positive 286.80 9.71 7 269145 131633 110188514
Arthropathy 278.60 9.71 178 268974 287344 110032803
Wound 262.30 9.71 121 269031 234316 110085831
Paranoia 261.39 9.71 297 268855 22077 110298070
Fall 258.88 9.71 2420 266732 601062 109719085
Cardiac arrest 256.23 9.71 1053 268099 195700 110124447
Drug ineffective 239.02 9.71 2460 266692 1518080 108802067
Rheumatic fever 238.63 9.71 15 269137 122564 110197583
Somnolence 238.28 9.71 1385 267767 296064 110024083
Aggression 232.30 9.71 472 268680 58738 110261409
Stomatitis 232.19 9.71 190 268962 270052 110050095
Depression suicidal 231.26 9.71 145 269007 4679 110315468
Tearfulness 229.78 9.71 170 268982 7225 110312922
Sleep disorder due to general medical condition, insomnia type 228.68 9.71 6 269146 105637 110214510
Intentional product misuse 228.66 9.71 778 268374 132126 110188021
Irritable bowel syndrome 226.10 9.71 60 269092 164155 110155992
C-reactive protein abnormal 222.42 9.71 27 269125 129668 110190479
Disturbance in attention 219.67 9.71 474 268678 61521 110258626
Irritability 219.14 9.71 407 268745 47402 110272745
Alopecia 218.16 9.71 344 268808 364409 109955738
Fibromyalgia 217.90 9.71 72 269080 170837 110149310
Therapeutic product effect decreased 215.88 9.71 167 268985 244149 110075998
Psychiatric decompensation 205.37 9.71 144 269008 5621 110314526
Impaired healing 201.43 9.71 114 269038 196603 110123544
Febrile neutropenia 200.79 9.71 287 268865 316480 110003667
Restlessness 195.73 9.71 427 268725 55832 110264315
Depressive symptom 195.64 9.71 163 268989 8251 110311896
Psoriatic arthropathy 194.43 9.71 119 269033 196642 110123505
Panic attack 193.77 9.71 292 268860 28648 110291499
Ill-defined disorder 191.50 9.71 71 269081 156782 110163365
Withdrawal syndrome 189.66 9.71 302 268850 31078 110289069
Seizure 185.64 9.71 1043 268109 220142 110100005
Loss of consciousness 181.15 9.71 950 268202 195356 110124791
Mydriasis 179.84 9.71 245 268907 21912 110298235
Blister 178.34 9.71 174 268978 227202 110092945
Infusion related reaction 172.18 9.71 424 268728 380738 109939409
Facet joint syndrome 171.45 9.71 18 269134 96810 110223337
C-reactive protein increased 169.48 9.71 168 268984 217751 110102396
Loss of libido 167.59 9.71 101 269051 3032 110317115
Accidental overdose 167.50 9.71 382 268770 51452 110268695
Electrocardiogram QRS complex prolonged 166.12 9.71 181 268971 12840 110307307
Depression 164.71 9.71 1328 267824 316007 110004140
Muscle twitching 164.54 9.71 276 268876 29659 110290488
Myelosuppression 163.34 9.71 19 269133 94321 110225826
Muscle rigidity 161.65 9.71 243 268909 23788 110296359
Hallucination 161.65 9.71 579 268573 100853 110219294
Psychotic disorder 160.86 9.71 372 268780 50565 110269582
Immunodeficiency 158.79 9.71 315 268837 38523 110281624
Blood cholesterol increased 158.58 9.71 130 269022 184655 110135492
Psychomotor skills impaired 158.47 9.71 134 269018 6924 110313223
Depressed mood 157.95 9.71 412 268740 60397 110259750
Foetal death 156.08 9.71 194 268958 15851 110304296
Akathisia 155.50 9.71 200 268952 16913 110303234
Unresponsive to stimuli 154.37 9.71 421 268731 63369 110256778
Lip dry 152.95 9.71 29 269123 100054 110220093
Swelling 152.72 9.71 398 268754 350643 109969504
Myoclonus 151.33 9.71 281 268871 32717 110287430
Nightmare 147.94 9.71 306 268846 38557 110281590
Pneumonia 147.77 9.71 1393 267759 875321 109444826
Treatment failure 144.39 9.71 285 268867 276949 110043198
Product use in unapproved indication 144.01 9.71 580 268572 446797 109873350
Drug intolerance 143.84 9.71 507 268645 406005 109914142
Discomfort 141.55 9.71 189 268963 214518 110105629
Accidental death 139.80 9.71 108 269044 4901 110315246
Lower respiratory tract infection 138.08 9.71 237 268915 242869 110077278
Maternal exposure during pregnancy 131.89 9.71 263 268889 254620 110065527
Obsessive-compulsive disorder 131.69 9.71 122 269030 7119 110313028
Hyperreflexia 130.08 9.71 137 269015 9348 110310799
Anorgasmia 128.57 9.71 68 269084 1578 110318569
Type 2 diabetes mellitus 125.18 9.71 148 269004 177084 110143063
Infection 123.97 9.71 458 268694 361742 109958405
Drug withdrawal syndrome 123.56 9.71 281 268871 37773 110282374
Parkinsonism 122.52 9.71 205 268947 21982 110298165
Malignant neoplasm progression 121.99 9.71 147 269005 174420 110145727
Lung disorder 119.17 9.71 158 268994 179889 110140258
Mania 117.32 9.71 194 268958 20602 110299545
Disorientation 115.66 9.71 407 268745 70264 110249883
Disinhibition 115.66 9.71 80 269072 3054 110317093
Liver injury 114.60 9.71 118 269034 150295 110169852
Depressed level of consciousness 114.50 9.71 559 268593 111719 110208428
Joint range of motion decreased 114.44 9.71 78 269074 121754 110198393
Wound infection 113.86 9.71 46 269106 96419 110223728
Peripheral swelling 113.54 9.71 551 268601 403483 109916664
Dementia 113.14 9.71 243 268909 31430 110288717
Joint swelling 111.51 9.71 627 268525 442218 109877929
Autoimmune disorder 111.36 9.71 14 269138 65469 110254678
Coma scale abnormal 110.04 9.71 127 269025 9599 110310548
Liver disorder 109.04 9.71 111 269041 142132 110178015
Nasopharyngitis 108.97 9.71 541 268611 393820 109926327
Libido decreased 107.94 9.71 100 269052 5835 110314312
Sinusitis 107.62 9.71 366 268786 296322 110023825
Septic shock 107.60 9.71 135 269017 157393 110162754
Long QT syndrome 106.99 9.71 108 269044 7010 110313137
Abdominal discomfort 104.46 9.71 548 268604 393310 109926837
Exposure via ingestion 103.84 9.71 90 269062 4810 110315337
Coeliac disease 103.46 9.71 284 268868 42903 110277244
Confusional state 103.25 9.71 1658 267494 467022 109853125
Peripheral venous disease 102.78 9.71 38 269114 84079 110236068
Cytokine release syndrome 102.00 9.71 23 269129 70283 110249864
Bruxism 100.36 9.71 89 269063 4905 110315242
Mood swings 99.31 9.71 190 268962 22622 110297525
Inappropriate antidiuretic hormone secretion 96.91 9.71 238 268914 33613 110286534
Grip strength decreased 95.00 9.71 38 269114 80136 110240011
Anger 94.96 9.71 168 268984 18839 110301308
Homicidal ideation 94.31 9.71 75 269077 3552 110316595
Hypercholesterolaemia 93.87 9.71 52 269100 90785 110229362
Dyskinesia 93.61 9.71 307 268845 51139 110269008
Interstitial lung disease 93.50 9.71 121 269031 139213 110180934
Rash erythematous 93.38 9.71 421 268731 81411 110238736
Adjustment disorder with depressed mood 93.11 9.71 3 269149 43880 110276267
Disease progression 92.66 9.71 295 268857 243739 110076408
Gastrointestinal disorder 92.21 9.71 292 268860 241660 110078487
Pyrexia 91.85 9.71 1586 267566 896679 109423468
Cytomegalovirus infection 91.71 9.71 12 269140 54432 110265715
Hepatic function abnormal 91.01 9.71 52 269100 89243 110230904
Inflammation 90.31 9.71 211 268941 193027 110127120
Psychomotor hyperactivity 89.64 9.71 170 268982 20107 110300040
Hallucination, auditory 89.14 9.71 198 268954 26199 110293948
Liver function test increased 88.21 9.71 53 269099 88495 110231652
Syncope 87.92 9.71 815 268337 201721 110118426
Lethargy 87.73 9.71 455 268697 93121 110227026
Lower limb fracture 87.20 9.71 37 269115 75311 110244836
Neutropenia 87.07 9.71 544 268608 374076 109946071
Thinking abnormal 86.43 9.71 142 269010 14998 110305149
Orgasmic sensation decreased 86.07 9.71 21 269131 32 110320115
Drug dependence 85.26 9.71 292 268860 49728 110270419
Bradyphrenia 85.23 9.71 123 269029 11605 110308542
Gait inability 84.92 9.71 125 269027 136251 110183896
Alcoholism 84.50 9.71 71 269081 3636 110316511
Mucosal inflammation 83.25 9.71 67 269085 96074 110224073
Onychomadesis 82.10 9.71 8 269144 45655 110274492
Psychomotor retardation 81.93 9.71 98 269054 7694 110312453
Hallucination, visual 81.86 9.71 247 268905 39358 110280789
Intentional product use issue 81.84 9.71 318 268834 247588 110072559
Urticaria 80.46 9.71 451 268701 318406 110001741
Erectile dysfunction 80.10 9.71 154 268998 18402 110301745
Alcohol poisoning 79.74 9.71 104 269048 8916 110311231
Blepharospasm 79.45 9.71 18 269134 54833 110265314
Haematemesis 78.16 9.71 318 268834 58790 110261357
Pulmonary fibrosis 77.78 9.71 80 269072 101962 110218185
Live birth 77.45 9.71 36 269116 69448 110250699
Alcohol use 76.03 9.71 70 269082 4052 110316095
Coma 75.67 9.71 519 268633 117350 110202797
Sexual dysfunction 74.86 9.71 98 269054 8432 110311715
Impulsive behaviour 74.55 9.71 63 269089 3252 110316895
Nail disorder 74.53 9.71 24 269128 57911 110262236
Bradykinesia 73.85 9.71 110 269042 10678 110309469
Abnormal behaviour 73.77 9.71 236 268916 38803 110281344
Galactorrhoea 73.62 9.71 69 269083 4086 110316061
Oedema 73.45 9.71 263 268889 209713 110110434
Pancytopenia 72.35 9.71 264 268888 209349 110110798
Mental impairment 71.10 9.71 165 268987 22474 110297673
Rash 71.08 9.71 1491 267661 819473 109500674
Tachyphrenia 70.60 9.71 53 269099 2303 110317844
Antipsychotic drug level below therapeutic 70.48 9.71 47 269105 1688 110318459
Bone erosion 69.66 9.71 14 269138 46357 110273790
Mobility decreased 69.44 9.71 319 268833 237103 110083044
Multiple organ dysfunction syndrome 69.01 9.71 168 268984 151542 110168605
Clonus 68.65 9.71 95 269057 8621 110311526
Intrusive thoughts 68.53 9.71 34 269118 687 110319460
Generalised tonic-clonic seizure 68.24 9.71 289 268863 54391 110265756
Sedation 68.23 9.71 343 268809 69340 110250807
Nicotine dependence 66.31 9.71 41 269111 1290 110318857
Cognitive disorder 65.78 9.71 401 268751 87110 110233037
Red blood cell sedimentation rate increased 64.81 9.71 57 269095 78245 110241902
Drug-induced liver injury 64.59 9.71 121 269031 119946 110200201
Contraindicated product administered 63.24 9.71 350 268802 247917 110072230
Drug screen positive 63.14 9.71 78 269074 6332 110313815
Musculoskeletal pain 62.84 9.71 231 268921 182792 110137355
Homicide 62.66 9.71 37 269115 1069 110319078
Taste disorder 62.56 9.71 41 269111 65346 110254801
Dizziness 62.30 9.71 2178 266974 696015 109624132
Mental disorder 62.26 9.71 222 268930 38569 110281578
Hepatic cytolysis 62.17 9.71 28 269124 55025 110265122
Fluid retention 62.17 9.71 418 268734 93889 110226258
Musculoskeletal stiffness 62.10 9.71 412 268740 279410 110040737
Increased appetite 61.85 9.71 122 269030 14855 110305292
Knee arthroplasty 61.77 9.71 41 269111 64907 110255240
Hepatic enzyme increased 61.34 9.71 493 268659 320399 109999748
Medication error 61.27 9.71 453 268699 104913 110215234
Haemophagocytic lymphohistiocytosis 61.00 9.71 4 269148 31555 110288592
Sciatica 60.19 9.71 82 269070 92317 110227830
Disturbance in sexual arousal 60.01 9.71 26 269126 380 110319767
Wheezing 59.59 9.71 370 268782 254860 110065287
Bradycardia 59.24 9.71 609 268543 154908 110165239
Euphoric mood 58.99 9.71 89 269063 8738 110311409
Alcohol abuse 58.54 9.71 66 269086 4863 110315284
Concussion 57.66 9.71 102 269050 11436 110308711
Night sweats 57.36 9.71 153 268999 133830 110186317
Osteoarthritis 56.65 9.71 240 268912 182383 110137764
Asphyxia 56.55 9.71 114 269038 14101 110306046
Condition aggravated 56.34 9.71 1360 267792 733476 109586671
Injury 56.20 9.71 231 268921 177034 110143113
Hip arthroplasty 56.16 9.71 33 269119 55780 110264367
Suicidal behaviour 56.14 9.71 55 269097 3442 110316705
Vertigo 56.05 9.71 383 268769 86487 110233660
Adverse event 55.62 9.71 113 269039 108696 110211451
Urinary retention 55.38 9.71 324 268828 69359 110250788
Abnormal dreams 55.08 9.71 106 269046 12674 110307473
Self-injurious ideation 54.72 9.71 60 269092 4286 110315861
Arthralgia 54.66 9.71 1462 267690 778170 109541977
Yawning 53.62 9.71 38 269114 1509 110318638
Substance abuse 53.26 9.71 103 269049 12360 110307787
Therapy non-responder 53.05 9.71 200 268952 157107 110163040
Exostosis 52.48 9.71 23 269129 45933 110274214
Cerebral vasoconstriction 52.32 9.71 37 269115 1464 110318683
Toxicologic test abnormal 52.12 9.71 35 269117 1272 110318875
Physical assault 51.87 9.71 38 269114 1590 110318557
Drug tolerance decreased 51.76 9.71 4 269148 27536 110292611
Sinus tachycardia 51.57 9.71 230 268922 44263 110275884
Negative thoughts 51.50 9.71 38 269114 1608 110318539
Platelet count decreased 51.27 9.71 339 268813 230104 110090043
Panic reaction 51.20 9.71 64 269088 5258 110314889
Major depression 50.65 9.71 92 269060 10529 110309618
Apathy 50.60 9.71 118 269034 16121 110304026
Drug resistance 50.43 9.71 38 269114 56336 110263811
Reversible cerebral vasoconstriction syndrome 50.26 9.71 60 269092 4701 110315446
Hostility 50.15 9.71 46 269106 2650 110317497
Acute kidney injury 49.51 9.71 1173 267979 634257 109685890
Pneumocystis jirovecii pneumonia 49.42 9.71 21 269131 42714 110277433
Tachycardia 49.14 9.71 800 268352 225845 110094302
Adrenal insufficiency 48.75 9.71 21 269131 42369 110277778
Speech disorder 48.75 9.71 286 268866 61283 110258864
Emotional distress 48.39 9.71 227 268925 44620 110275527
Alcohol interaction 48.26 9.71 52 269100 3642 110316505
Hypertonia 48.20 9.71 79 269073 8327 110311820
Somnambulism 47.76 9.71 68 269084 6337 110313810
Drug ineffective for unapproved indication 47.46 9.71 113 269039 102725 110217422
Angiodermatitis 47.39 9.71 18 269134 183 110319964
Feeling abnormal 46.98 9.71 658 268494 180053 110140094
Crying 46.68 9.71 153 268999 25475 110294672
Restless legs syndrome 46.64 9.71 149 269003 24477 110295670
Genital hypoaesthesia 46.21 9.71 18 269134 197 110319950
Tinnitus 45.87 9.71 278 268874 60262 110259885
Parathyroid gland enlargement 45.81 9.71 18 269134 202 110319945
Poor quality sleep 45.33 9.71 161 268991 27916 110292231
Hyperventilation 44.59 9.71 79 269073 8868 110311279
Circulatory collapse 44.49 9.71 215 268937 42778 110277369
Stress 44.23 9.71 421 268731 104927 110215220
Myocardial stunning 44.20 9.71 20 269132 326 110319821
Prescribed overdose 43.45 9.71 363 268789 87218 110232929
Burns second degree 43.43 9.71 72 269080 7661 110312486
Delusion 43.43 9.71 142 269010 23613 110296534
Hypoglycaemia 43.42 9.71 453 268699 115651 110204496
Bronchopulmonary aspergillosis 42.85 9.71 10 269142 29853 110290294
Sputum purulent 42.54 9.71 36 269116 1862 110318285
Back injury 42.34 9.71 32 269120 47367 110272780
Logorrhoea 42.03 9.71 56 269096 4901 110315246
Balance disorder 41.36 9.71 450 268702 116110 110204037
Therapeutic product effect incomplete 41.31 9.71 347 268805 223458 110096689
Mental status changes 41.29 9.71 322 268830 75800 110244347
Libido increased 40.89 9.71 40 269112 2499 110317648
Calcium deficiency 40.89 9.71 29 269123 1153 110318994
Neuropathy peripheral 40.75 9.71 262 268890 179015 110141132
Constipation 40.49 9.71 1149 268003 356637 109963510
Therapeutic product effect variable 40.41 9.71 41 269111 2677 110317470
Product prescribing error 40.35 9.71 238 268914 51093 110269054
Upper respiratory tract infection 40.33 9.71 493 268659 130835 110189312
Prescribed underdose 40.31 9.71 60 269092 65114 110255033
Angle closure glaucoma 40.11 9.71 46 269106 3453 110316694
Sepsis 40.09 9.71 558 268594 326788 109993359
Cholecystitis chronic 39.97 9.71 78 269074 9422 110310725
Brain injury 39.91 9.71 96 269056 13380 110306767
General physical health deterioration 39.83 9.71 762 268390 424533 109895614
Neuroglycopenia 39.82 9.71 28 269124 1098 110319049
Haematotoxicity 39.80 9.71 3 269149 21079 110299068
Catarrh 39.47 9.71 67 269085 7268 110312879
Antidepressant drug level above therapeutic 39.45 9.71 24 269128 733 110319414
Neuroleptic malignant syndrome 39.43 9.71 176 268976 33883 110286264
Cardiac failure 39.26 9.71 281 268871 187345 110132802
Road traffic accident 39.24 9.71 132 269020 107266 110212881
Dystonia 39.14 9.71 145 269007 25660 110294487
Illness anxiety disorder 38.96 9.71 17 269135 253 110319894
Premature ejaculation 38.89 9.71 12 269140 60 110320087
Lupus-like syndrome 38.45 9.71 26 269126 40766 110279381
Swollen tongue 38.26 9.71 265 268887 60097 110260050
Incoherent 38.10 9.71 71 269081 8287 110311860
Rib deformity 38.07 9.71 16 269136 216 110319931
Rhinitis perennial 37.94 9.71 16 269136 218 110319929
Nervousness 37.93 9.71 184 268968 36667 110283480
Hypokinesia 37.70 9.71 128 269024 21698 110298449
Drug hypersensitivity 37.66 9.71 830 268322 453260 109866887
Thrombotic microangiopathy 37.63 9.71 12 269140 29137 110291010
Onychomycosis 37.08 9.71 24 269128 38507 110281640
Myocardial fibrosis 37.03 9.71 34 269118 1961 110318186
CFTR gene mutation 36.98 9.71 16 269136 233 110319914
Chronic sinusitis 36.80 9.71 8 269144 25076 110295071
Psychiatric symptom 36.78 9.71 74 269078 9139 110311008
Acute myeloid leukaemia 36.32 9.71 24 269128 38086 110282061
Tardive dyskinesia 36.28 9.71 93 269059 13486 110306661
Neurodegenerative disorder 36.08 9.71 23 269129 764 110319383
Tumour lysis syndrome 35.84 9.71 15 269137 30786 110289361
Hypopnoea 35.80 9.71 83 269069 11297 110308850
Renal impairment 35.76 9.71 290 268862 188155 110131992
Melaena 35.73 9.71 288 268864 68469 110251678
Diabetic hyperosmolar coma 35.60 9.71 24 269128 878 110319269
Schizoaffective disorder 35.56 9.71 41 269111 3095 110317052
Gun shot wound 35.53 9.71 26 269126 1086 110319061
Suspected suicide 35.46 9.71 99 269053 15100 110305047
Tic 35.21 9.71 43 269109 3450 110316697
Pulseless electrical activity 35.09 9.71 105 269047 16652 110303495
Stupor 34.95 9.71 68 269084 8197 110311950
Laryngitis 34.94 9.71 31 269121 42380 110277767
Product use issue 34.80 9.71 541 268611 311154 110008993
Prescription drug used without a prescription 34.74 9.71 54 269098 5442 110314705
Ascites 34.64 9.71 113 269039 92695 110227452
Maternal exposure timing unspecified 34.52 9.71 5 269147 21008 110299139
Upper respiratory fungal infection 34.37 9.71 18 269134 409 110319738
Injection site reaction 34.25 9.71 107 269045 88963 110231184
Fear 34.08 9.71 129 269023 23064 110297083
Forced expiratory volume 34.01 9.71 12 269140 97 110320050
Catatonia 34.00 9.71 81 269071 11219 110308928
Pneumonitis 33.82 9.71 86 269066 76445 110243702
Steroid dependence 33.78 9.71 68 269084 8401 110311746
Rhinitis 33.63 9.71 126 269026 22419 110297728
Oedema peripheral 33.54 9.71 580 268572 328080 109992067
Hyponatraemic syndrome 33.37 9.71 22 269130 775 110319372
Dysphemia 33.30 9.71 45 269107 3992 110316155
Dysarthria 33.26 9.71 332 268820 83789 110236358
Rabbit syndrome 33.04 9.71 17 269135 372 110319775
Pleural effusion 33.03 9.71 275 268877 177434 110142713
Anaemia 32.98 9.71 1047 268105 546039 109774108
Post-traumatic neck syndrome 32.98 9.71 36 269116 2559 110317588
Drug reaction with eosinophilia and systemic symptoms 32.73 9.71 97 269055 81998 110238149
Dyspnoea 32.72 9.71 2287 266865 1104585 109215562
Hyperprolactinaemia 32.69 9.71 58 269094 6517 110313630
Pulmonary alveolar haemorrhage 32.63 9.71 5 269147 20145 110300002
Hallucinations, mixed 32.55 9.71 68 269084 8625 110311522
Hypersomnia 32.48 9.71 145 269007 27916 110292231
Impaired work ability 32.47 9.71 139 269013 26280 110293867
Premature delivery 32.43 9.71 17 269135 30615 110289532
Multiple sclerosis relapse 32.10 9.71 221 268931 50019 110270128
Ventricular tachycardia 31.96 9.71 220 268932 49789 110270358
Palpitations 31.94 9.71 555 268597 158657 110161490
Drug eruption 31.65 9.71 51 269101 53608 110266539
Macular degeneration 31.59 9.71 7 269145 21652 110298495
Soft tissue injury 31.43 9.71 33 269119 2243 110317904
Posterior reversible encephalopathy syndrome 31.36 9.71 22 269130 33839 110286308
Myelodysplastic syndrome 31.36 9.71 27 269125 37457 110282690
Poverty of speech 31.18 9.71 19 269133 582 110319565
Tension 30.86 9.71 49 269103 5029 110315118
Female sexual arousal disorder 30.83 9.71 7 269145 6 110320141
Blood alcohol increased 30.57 9.71 23 269129 1003 110319144
Flat affect 30.53 9.71 34 269118 2471 110317676
Sternal fracture 30.51 9.71 39 269113 3277 110316870
Pruritus 30.41 9.71 1133 268019 580427 109739720
Head injury 30.37 9.71 194 268958 42823 110277324
Hypogammaglobulinaemia 30.28 9.71 6 269146 20070 110300077
Hospitalisation 30.01 9.71 213 268939 142280 110177867
Peripheral circulatory failure 29.94 9.71 29 269123 1790 110318357
Neoplasm progression 29.79 9.71 71 269081 64524 110255623
Self-medication 29.74 9.71 54 269098 6178 110313969
Obsessive thoughts 29.72 9.71 25 269127 1282 110318865
Pulmonary oedema 29.67 9.71 375 268777 100284 110219863
Neonatal infection 29.65 9.71 8 269144 22 110320125
Extrapyramidal disorder 29.61 9.71 144 269008 28723 110291424
Back pain 29.52 9.71 1143 268009 369853 109950294
Therapy partial responder 29.45 9.71 28 269124 37033 110283114
Blood uric acid increased 29.37 9.71 8 269144 21521 110298626
End stage renal disease 29.25 9.71 8 269144 21465 110298682
Adverse reaction 29.07 9.71 18 269134 29576 110290571
Personality change 29.03 9.71 75 269077 10927 110309220
Respiratory tract infection 29.00 9.71 84 269068 71533 110248614
Insomnia 28.94 9.71 1112 268040 359478 109960669
Post viral fatigue syndrome 28.72 9.71 14 269138 272 110319875
Bezoar 28.71 9.71 42 269110 4012 110316135
Hypotonia 28.67 9.71 94 269058 15651 110304496
Initial insomnia 28.63 9.71 72 269080 10317 110309830
Drug abuser 28.57 9.71 49 269103 5360 110314787
Dysgeusia 28.54 9.71 278 268874 69707 110250440
COVID-19 pneumonia 28.44 9.71 29 269123 37114 110283033
Anticholinergic syndrome 28.38 9.71 43 269109 4237 110315910
Hepatic cirrhosis 28.36 9.71 78 269074 67548 110252599
Blood cholesterol decreased 28.30 9.71 34 269118 2682 110317465
Antidepressant drug level increased 28.24 9.71 18 269134 598 110319549
Arrhythmia 28.19 9.71 276 268876 69299 110250848
Palmar-plantar erythrodysaesthesia syndrome 28.16 9.71 35 269117 40990 110279157
Psoriasis 28.08 9.71 488 268664 139505 110180642
Substance dependence 27.92 9.71 19 269133 706 110319441
Gestational diabetes 27.90 9.71 58 269094 7331 110312816
Ulcer haemorrhage 27.90 9.71 10 269142 22561 110297586
Lip swelling 27.85 9.71 215 268937 50452 110269695
Spontaneous penile erection 27.72 9.71 12 269140 175 110319972
Activation syndrome 27.72 9.71 15 269137 365 110319782
Underdose 27.63 9.71 72 269080 63482 110256665
Derealisation 27.53 9.71 30 269122 2128 110318019
Cogwheel rigidity 27.19 9.71 39 269113 3659 110316488
Hypervigilance 27.18 9.71 18 269134 639 110319508
Labelled drug-drug interaction issue 26.91 9.71 41 269111 4060 110316087
Failure to suspend medication 26.86 9.71 16 269136 470 110319677
Rheumatoid nodule 26.84 9.71 8 269144 20288 110299859
Normal newborn 26.56 9.71 10 269142 21886 110298261
Aplastic anaemia 26.47 9.71 13 269139 24295 110295852
Hypochloraemia 26.37 9.71 38 269114 3580 110316567
Bone marrow failure 26.34 9.71 64 269088 57784 110262363
Social avoidant behaviour 26.23 9.71 47 269105 5322 110314825
Bipolar I disorder 26.15 9.71 30 269122 2253 110317894
Parosmia 26.11 9.71 81 269071 13099 110307048
Cytopenia 26.05 9.71 21 269131 30095 110290052
Radiologically isolated syndrome 25.98 9.71 6 269146 6 110320141
Muscle tightness 25.88 9.71 87 269065 14675 110305472
Dry mouth 25.85 9.71 337 268815 199611 110120536
Hypersensitivity 25.83 9.71 767 268385 403231 109916916
Orgasm abnormal 25.80 9.71 12 269140 209 110319938
Diarrhoea 25.73 9.71 2406 266746 1137099 109183048
Opiates positive 25.67 9.71 20 269132 919 110319228
Toxic epidermal necrolysis 25.65 9.71 63 269089 56664 110263483
Immune effector cell-associated neurotoxicity syndrome 25.53 9.71 3 269149 14779 110305368
Orthostatic hypotension 25.49 9.71 260 268892 65989 110254158
Transplant rejection 25.47 9.71 14 269138 24553 110295594
Pulmonary toxicity 25.35 9.71 6 269146 17740 110302407
Carbuncle 25.30 9.71 24 269128 1443 110318704
Rash maculo-papular 25.25 9.71 94 269058 74128 110246019
Lactic acidosis 25.20 9.71 128 269024 92683 110227464
Atrioventricular block first degree 25.08 9.71 84 269068 14141 110306006
Dissociative amnesia 25 9.71 10 269142 118 110320029
Carcinoid heart disease 24.96 9.71 9 269143 78 110320069
Polyhydramnios 24.88 9.71 27 269125 1906 110318241
Sleep disorder 24.88 9.71 337 268815 198307 110121840
Caesarean section 24.72 9.71 82 269070 13735 110306412
Neuropathy, ataxia, retinitis pigmentosa syndrome 24.72 9.71 8 269144 48 110320099
Panic disorder 24.72 9.71 36 269116 3425 110316722
Pseudomonas infection 24.63 9.71 19 269133 27834 110292313
Sexually inappropriate behaviour 24.46 9.71 17 269135 654 110319493
Myositis 24.16 9.71 24 269128 31092 110289055
Venoocclusive liver disease 24.11 9.71 4 269148 15203 110304944
Multiple sclerosis 24.11 9.71 125 269027 25573 110294574
Enterocolitis 24.11 9.71 8 269144 18941 110301206
Hypocalcaemia 24.11 9.71 80 269072 65286 110254861
Prostate cancer 23.92 9.71 34 269118 37607 110282540
Respiratory disorder 23.90 9.71 91 269061 71291 110248856
Neglect of personal appearance 23.85 9.71 14 269138 400 110319747
Disability 23.82 9.71 23 269129 30200 110289947
Dreamy state 23.79 9.71 8 269144 55 110320092
Testicular atrophy 23.79 9.71 14 269138 402 110319745
Dysphoria 23.74 9.71 50 269102 6378 110313769
Epstein-Barr virus infection 23.68 9.71 8 269144 18730 110301417
Mood altered 23.65 9.71 109 269043 21266 110298881
Fatigue 23.64 9.71 3339 265813 1212619 109107528
Walking aid user 23.61 9.71 16 269136 25059 110295088
Therapeutic response decreased 23.50 9.71 138 269014 96361 110223786
Cytomegalovirus viraemia 23.49 9.71 7 269145 17757 110302390
Agoraphobia 23.47 9.71 17 269135 699 110319448
Legal problem 23.40 9.71 10 269142 141 110320006
Bipolar disorder 23.35 9.71 61 269091 8946 110311201
Infusion site reaction 23.32 9.71 7 269145 17675 110302472
Vasoplegia syndrome 23.30 9.71 45 269107 5394 110314753
Persistent depressive disorder 23.28 9.71 23 269129 1454 110318693
Self esteem decreased 23.26 9.71 20 269132 1057 110319090
Sensory disturbance 23.22 9.71 94 269058 17335 110302812
Heavy menstrual bleeding 23.20 9.71 90 269062 16275 110303872
Incontinence 23.19 9.71 91 269061 16544 110303603
Postmortem blood drug level increased 23.10 9.71 21 269131 1196 110318951
Hanging 23.03 9.71 11 269141 204 110319943
Antipsychotic drug level above therapeutic 22.93 9.71 29 269123 2411 110317736
Cardiomegaly 22.85 9.71 135 269017 28995 110291152
Ventricular arrhythmia 22.84 9.71 65 269087 10022 110310125
Dyspepsia 22.84 9.71 327 268825 190638 110129509
Stoma site pain 22.83 9.71 26 269126 1937 110318210
Dyslipidaemia 22.80 9.71 88 269064 15877 110304270
Nystagmus 22.80 9.71 71 269081 11506 110308641
Female genital tract fistula 22.79 9.71 6 269146 16513 110303634
Decreased interest 22.76 9.71 42 269110 4866 110315281
Blood creatine phosphokinase increased 22.72 9.71 275 268877 72802 110247345
Eosinophilia 22.70 9.71 69 269083 57867 110262280
Histrionic personality disorder 22.69 9.71 7 269145 35 110320112
Glabellar reflex abnormal 22.69 9.71 7 269145 35 110320112
Foetal chromosome abnormality 22.64 9.71 6 269146 15 110320132
Diaphragmatic rupture 22.64 9.71 11 269141 212 110319935
Red blood cell sedimentation rate abnormal 22.60 9.71 16 269136 24493 110295654
Arthritis 22.58 9.71 280 268872 167306 110152841
Multiple drug therapy 22.57 9.71 56 269096 7958 110312189
Andropause 22.52 9.71 9 269143 106 110320041
No adverse event 22.30 9.71 98 269054 73741 110246406
Product administration error 22.19 9.71 161 268991 37056 110283091
Craniofacial fracture 22.09 9.71 18 269134 883 110319264
Movement disorder 22.01 9.71 158 268994 36246 110283901
Stoma site inflammation 21.91 9.71 19 269133 1016 110319131
Thrombocytopenia 21.89 9.71 664 268488 348221 109971926
Dissociation 21.88 9.71 63 269089 9779 110310368
Bladder cancer 21.87 9.71 11 269141 20281 110299866
Respiratory depression 21.78 9.71 143 269009 31858 110288289
Hypoalbuminaemia 21.75 9.71 23 269129 28951 110291196
Bronchomalacia 21.74 9.71 12 269140 304 110319843
Amnesia 21.70 9.71 369 268783 105039 110215108
Vascular access site thrombosis 21.65 9.71 9 269143 118 110320029
Pathogen resistance 21.56 9.71 8 269144 17664 110302483
Respiratory symptom 21.45 9.71 5 269147 14940 110305207
Heat stroke 21.44 9.71 25 269127 1910 110318237
Hot flush 21.19 9.71 250 268902 65786 110254361
Optic ischaemic neuropathy 21.16 9.71 37 269115 4110 110316037
Hiatus hernia 21.06 9.71 127 269025 27479 110292668
Orthostatic intolerance 21.00 9.71 26 269126 2115 110318032
Obstructive defaecation 20.96 9.71 11 269141 251 110319896
Pancreatitis relapsing 20.78 9.71 22 269130 1510 110318637
Pupillary reflex impaired 20.72 9.71 36 269116 3979 110316168
Parkinson's disease 20.70 9.71 22 269130 1517 110318630
Hyperphosphataemia 20.69 9.71 7 269145 16374 110303773
Pneumonia bacterial 20.68 9.71 20 269132 26241 110293906
Basal ganglion degeneration 20.63 9.71 13 269139 423 110319724
Post-traumatic stress disorder 20.63 9.71 48 269104 6548 110313599
Monoclonal immunoglobulin present 20.48 9.71 28 269124 2512 110317635
Wrong product administered 20.47 9.71 66 269086 10894 110309253
Hepatic steatosis 20.42 9.71 195 268957 48636 110271511
Decreased appetite 20.41 9.71 948 268204 474898 109845249
Eyelid function disorder 20.37 9.71 14 269138 529 110319618
Facial spasm 20.33 9.71 17 269135 865 110319282
Thrombosis 20.25 9.71 168 268984 108494 110211653
Disorganised speech 20.25 9.71 32 269120 3271 110316876
Hyperbilirubinaemia 20.19 9.71 27 269125 30644 110289503
Vaginal haemorrhage 20.19 9.71 117 269035 24957 110295190
Hypercalcaemia 20.18 9.71 53 269099 46604 110273543
Sexual inhibition 20.08 9.71 4 269148 0 110320147
Nocturnal emission 20.08 9.71 4 269148 0 110320147
Heart rate increased 20.06 9.71 475 268677 143359 110176788
Headache 20.01 9.71 2446 266706 879931 109440216
Intestinal congestion 19.98 9.71 5 269147 9 110320138
Loss of bladder sensation 19.96 9.71 8 269144 95 110320052
Decreased immune responsiveness 19.93 9.71 60 269092 9546 110310601
Interstitial granulomatous dermatitis 19.78 9.71 11 269141 283 110319864
Anhedonia 19.60 9.71 82 269070 15346 110304801
Stoma site dermatitis 19.60 9.71 11 269141 288 110319859
Hypomania 19.54 9.71 62 269090 10148 110309999
Atrial fibrillation 19.51 9.71 418 268734 229224 110090923
Gender dysphoria 19.48 9.71 7 269145 60 110320087
Cerebrospinal fluid retention 19.45 9.71 8 269144 102 110320045
Labelled drug-drug interaction medication error 19.38 9.71 130 269022 29172 110290975
Atonic urinary bladder 19.34 9.71 9 269143 157 110319990
Vascular access site infection 19.34 9.71 9 269143 157 110319990
Polyneuropathy 19.28 9.71 30 269122 31982 110288165
Sebaceous gland infection 19.18 9.71 9 269143 160 110319987
Panniculitis 19.10 9.71 7 269145 15575 110304572
Graft versus host disease 19.09 9.71 11 269141 18795 110301352
Musculoskeletal chest pain 19.09 9.71 128 269024 28719 110291428
Menopause 19.00 9.71 27 269125 2511 110317636
Cardiac death 18.94 9.71 22 269130 1674 110318473
Cholangitis 18.93 9.71 8 269144 16327 110303820
Anhidrosis 18.84 9.71 12 269140 398 110319749
Atrophic vulvovaginitis 18.80 9.71 20 269132 1380 110318767
White blood cell count decreased 18.78 9.71 420 268732 228970 110091177
Hypoaesthesia 18.75 9.71 602 268550 313621 110006526
Hyperuricaemia 18.72 9.71 6 269146 14525 110305622
Antipsychotic drug level increased 18.69 9.71 48 269104 6967 110313180
Disseminated intravascular coagulation 18.55 9.71 46 269106 41240 110278907
CYP3A4 polymorphism 18.53 9.71 7 269145 70 110320077
Cardiac steatosis 18.53 9.71 7 269145 70 110320077
Aspergillus infection 18.50 9.71 21 269131 25595 110294552
Muscular weakness 18.39 9.71 462 268690 248006 110072141
Urinary incontinence 18.36 9.71 190 268962 48397 110271750
Dermatillomania 18.32 9.71 11 269141 328 110319819
Abnormal weight gain 18.27 9.71 32 269120 3559 110316588
Hyperthermia 18.27 9.71 101 269051 21171 110298976
Gastrointestinal stoma output abnormal 18.27 9.71 12 269140 420 110319727
Libido disorder 18.23 9.71 11 269141 331 110319816
Hypokalaemia 18.21 9.71 577 268575 181871 110138276
Memory impairment 18.15 9.71 617 268535 196327 110123820
Organising pneumonia 18.14 9.71 6 269146 14237 110305910
Hypersexuality 18.14 9.71 23 269129 1917 110318230
Drug withdrawal syndrome neonatal 18.14 9.71 11 269141 334 110319813
Injection site pain 18.13 9.71 314 268838 177608 110142539
Secondary immunodeficiency 18.01 9.71 37 269115 4639 110315508
Gingival pain 17.97 9.71 81 269071 15655 110304492
Heterophoria 17.94 9.71 7 269145 77 110320070
Educational problem 17.94 9.71 13 269139 535 110319612
Conduction disorder 17.93 9.71 34 269118 4021 110316126
Spermatozoa morphology abnormal 17.85 9.71 4 269148 3 110320144
Electrolyte substitution therapy 17.85 9.71 4 269148 3 110320144
Pelvic fracture 17.80 9.71 75 269077 14079 110306068
Anaphylactic shock 17.72 9.71 65 269087 51481 110268666
Morbid thoughts 17.72 9.71 16 269136 903 110319244
Cystitis haemorrhagic 17.69 9.71 4 269148 12205 110307942
Therapy interrupted 17.68 9.71 62 269090 49760 110270387
Subclavian artery thrombosis 17.51 9.71 6 269146 44 110320103
Haematuria 17.51 9.71 124 269028 82881 110237266
Foot deformity 17.42 9.71 60 269092 48420 110271727
Amputation stump pain 17.39 9.71 6 269146 45 110320102
Feeling guilty 17.32 9.71 16 269136 930 110319217
Adenovirus infection 17.19 9.71 3 269149 10991 110309156
Muscle tension dysphonia 17.15 9.71 10 269142 282 110319865
Intervertebral disc disorder 17.12 9.71 40 269112 5472 110314675
Genital anaesthesia 17.11 9.71 5 269147 20 110320127
Joint destruction 17.08 9.71 3 269149 10940 110309207
Neutrophil count decreased 17.08 9.71 200 268952 120741 110199406
Muscle mass 17.05 9.71 12 269140 471 110319676
Metastases to liver 17.04 9.71 38 269114 35348 110284799
Hyperkinesia 17.02 9.71 29 269123 3155 110316992
Polymenorrhagia 16.95 9.71 6 269146 49 110320098
Enzyme inhibition 16.91 9.71 8 269144 145 110320002
Product substitution issue 16.90 9.71 105 269047 22956 110297191
Hepatitis 16.89 9.71 139 269013 89915 110230232
International normalised ratio increased 16.87 9.71 301 268851 86471 110233676
Emotional disorder 16.85 9.71 81 269071 16079 110304068
Appendicitis 16.84 9.71 27 269125 28437 110291710
Uterine enlargement 16.77 9.71 16 269136 969 110319178
Dermatitis bullous 16.75 9.71 11 269141 17518 110302629
Aspartate aminotransferase increased 16.70 9.71 281 268871 159655 110160492
Posturing 16.69 9.71 17 269135 1115 110319032
Acute graft versus host disease in skin 16.65 9.71 3 269149 10737 110309410
Nodule 16.58 9.71 34 269118 32597 110287550
Cardiac failure congestive 16.53 9.71 263 268889 150737 110169410
Mucormycosis 16.40 9.71 3 269149 10625 110309522
Dysaesthesia 16.37 9.71 45 269107 6802 110313345
Male sexual dysfunction 16.28 9.71 10 269142 311 110319836
Blood osmolarity decreased 16.22 9.71 19 269133 1459 110318688
Osteonecrosis of jaw 16.21 9.71 61 269091 47956 110272191
Gallbladder disorder 16.20 9.71 97 269055 20932 110299215
Postprandial hypoglycaemia 16.11 9.71 8 269144 162 110319985
Breath sounds abnormal 16.09 9.71 23 269129 25381 110294766
Ankylosing spondylitis 16.04 9.71 9 269143 15603 110304544
Skin warm 16.03 9.71 54 269098 9116 110311031
Liver function test abnormal 15.92 9.71 246 268906 68704 110251443
Drug level increased 15.91 9.71 182 268970 47537 110272610
Tobacco user 15.90 9.71 14 269138 764 110319383
Blood prolactin increased 15.88 9.71 35 269117 4607 110315540
Retching 15.83 9.71 102 269050 22580 110297567
Vertigo CNS origin 15.74 9.71 5 269147 28 110320119
Blunted affect 15.74 9.71 12 269140 534 110319613
Pulse pressure decreased 15.70 9.71 11 269141 429 110319718
Hypophosphataemia 15.68 9.71 36 269116 33146 110287001
Finger deformity 15.56 9.71 36 269116 33056 110287091
Semen volume decreased 15.54 9.71 6 269146 64 110320083
Metastases to lung 15.49 9.71 20 269132 23043 110297104
Product storage error 15.49 9.71 18 269134 21710 110298437
Gastrointestinal toxicity 15.48 9.71 4 269148 11144 110309003
Drug dose omission by device 15.45 9.71 8 269144 14508 110305639
Female orgasmic disorder 15.45 9.71 5 269147 30 110320117
Benign prostatic hyperplasia 15.42 9.71 13 269139 18221 110301926
Acute generalised exanthematous pustulosis 15.38 9.71 18 269134 21646 110298501
Sleep terror 15.37 9.71 43 269109 6567 110313580
Kidney transplant rejection 15.36 9.71 5 269147 11982 110308165
Violence-related symptom 15.24 9.71 15 269137 944 110319203
Skin laceration 15.22 9.71 137 269015 33616 110286531
Differential white blood cell count abnormal 15.22 9.71 23 269129 2261 110317886
Bacterial infection 15.21 9.71 59 269093 45977 110274170
Rib fracture 15.20 9.71 137 269015 33633 110286514
Haematospermia 15.18 9.71 9 269143 262 110319885
Neonatal seizure 15.17 9.71 5 269147 32 110320115
Facial paralysis 15.16 9.71 106 269046 24108 110296039
Lymphoma 15.16 9.71 16 269136 20155 110299992
Gastrointestinal procedural complication 15.15 9.71 11 269141 454 110319693
Dermatitis exfoliative generalised 15.11 9.71 4 269148 10968 110309179
Product quality issue 15.10 9.71 118 269034 77181 110242966
New daily persistent headache 15.06 9.71 3 269149 0 110320147
Oral candidiasis 15.02 9.71 57 269095 44703 110275444
COVID-19 14.97 9.71 468 268684 244592 110075555
Skin toxicity 14.95 9.71 5 269147 11778 110308369
Sexual relationship change 14.82 9.71 4 269148 11 110320136
Ejaculation delayed 14.77 9.71 8 269144 195 110319952
Cataract 14.76 9.71 123 269029 79362 110240785
On and off phenomenon 14.73 9.71 33 269119 4391 110315756
Subdural haemorrhage 14.60 9.71 42 269110 6516 110313631
Rhabdomyolysis 14.54 9.71 390 268762 120011 110200136
Eosinophilic granulomatosis with polyangiitis 14.52 9.71 4 269148 10682 110309465
Lip pruritus 14.52 9.71 17 269135 1305 110318842
Ataxia 14.51 9.71 124 269028 29984 110290163
Nasal polyps 14.46 9.71 7 269145 13193 110306954
Skin ulcer 14.46 9.71 93 269059 63552 110256595
Trismus 14.45 9.71 42 269110 6554 110313593
Pyelonephritis chronic 14.42 9.71 9 269143 288 110319859
Marital problem 14.41 9.71 8 269144 205 110319942
Proctitis 14.40 9.71 12 269140 16915 110303232
Cystoid macular oedema 14.31 9.71 25 269127 2775 110317372
Polyarthritis 14.30 9.71 15 269137 18948 110301199
Facial bones fracture 14.28 9.71 35 269117 4936 110315211
Drug level above therapeutic 14.26 9.71 61 269091 11527 110308620
Emotional poverty 14.22 9.71 15 269137 1025 110319122
Biliary dyskinesia 14.22 9.71 23 269129 2398 110317749
Job dissatisfaction 14.21 9.71 6 269146 82 110320065
Vision blurred 14.20 9.71 413 268739 128609 110191538
Cholecystectomy 14.16 9.71 58 269094 10751 110309396
Dysponesis 14.11 9.71 5 269147 41 110320106
Blood catecholamines decreased 14.10 9.71 4 269148 14 110320133
Anosmia 14.10 9.71 64 269088 12408 110307739
Blood creatinine increased 14.09 9.71 338 268814 182551 110137596
Underweight 14.09 9.71 18 269134 1512 110318635
Blood ethanol increased 14.04 9.71 12 269140 629 110319518
Detoxification 14.02 9.71 6 269146 85 110320062
Influenza 14.02 9.71 309 268843 168792 110151355
Hypothalamo-pituitary disorder 14.02 9.71 25 269127 2821 110317326
Death 14.00 9.71 1923 267229 696946 109623201
Delirium 13.99 9.71 429 268723 134596 110185551
Economic problem 13.96 9.71 31 269121 4100 110316047
Gastric polyps 13.91 9.71 37 269115 5486 110314661
Chronic graft versus host disease 13.90 9.71 3 269149 9454 110310693
Abdominal pain upper 13.88 9.71 701 268451 348410 109971737
Gastrointestinal sounds abnormal 13.84 9.71 39 269113 5979 110314168
Hepatitis C virus test positive 13.81 9.71 10 269142 411 110319736
Fine motor skill dysfunction 13.79 9.71 40 269112 6234 110313913
Cardiotoxicity 13.74 9.71 79 269073 16802 110303345
Acute respiratory failure 13.73 9.71 117 269035 75143 110245004
Executive dysfunction 13.72 9.71 10 269142 415 110319732
Vitamin D abnormal 13.71 9.71 8 269144 226 110319921
Meningitis streptococcal 13.71 9.71 8 269144 226 110319921
Urine abnormality 13.70 9.71 51 269101 9045 110311102
Toxic skin eruption 13.70 9.71 29 269123 27486 110292661
Meconium in amniotic fluid 13.70 9.71 7 269145 151 110319996
Pneumonia viral 13.69 9.71 5 269147 11152 110308995
Hypoxic-ischaemic encephalopathy 13.66 9.71 50 269102 8797 110311350
Dissociative disorder 13.59 9.71 16 269136 1235 110318912
Hip fracture 13.54 9.71 138 269014 35013 110285134
Tongue biting 13.44 9.71 25 269127 2914 110317233
Sudden cardiac death 13.43 9.71 37 269115 5600 110314547
Osmolar gap abnormal 13.42 9.71 6 269146 95 110320052
Allergic sinusitis 13.41 9.71 19 269133 1762 110318385
Feeling of despair 13.40 9.71 29 269123 3769 110316378
Drug effective for unapproved indication 13.39 9.71 9 269143 14158 110305989
Saliva altered 13.37 9.71 11 269141 547 110319600
Gastritis 13.33 9.71 194 268958 53505 110266642
Shock haemorrhagic 13.33 9.71 29 269123 27218 110292929
Pulmonary arterial hypertension 13.33 9.71 38 269114 32530 110287617
Gastritis alcoholic 13.31 9.71 4 269148 18 110320129
Stoma site infection 13.30 9.71 19 269133 1776 110318371
Teratogenicity 13.25 9.71 8 269144 241 110319906
Lipoedema 13.25 9.71 8 269144 241 110319906
Acute stress disorder 13.21 9.71 11 269141 556 110319591
Congestive hepatopathy 13.17 9.71 35 269117 5185 110314962
Feeling of body temperature change 13.17 9.71 39 269113 6149 110313998
Nodal arrhythmia 13.17 9.71 21 269131 2163 110317984
Visual field defect 13.16 9.71 54 269098 10018 110310129
Pneumonia fungal 13.13 9.71 10 269142 14744 110305403
Ear infection 13.09 9.71 94 269058 62638 110257509
Adjusted calcium decreased 13.02 9.71 8 269144 249 110319898
Alcoholic psychosis 12.99 9.71 3 269149 3 110320144
Bisexuality 12.99 9.71 3 269149 3 110320144
Electrocardiogram QT interval abnormal 12.93 9.71 9 269143 347 110319800
Tension headache 12.91 9.71 52 269100 9566 110310581
Cerebral atrophy 12.91 9.71 50 269102 9035 110311112
Hepatocellular carcinoma 12.87 9.71 4 269148 9876 110310271
Jaundice cholestatic 12.87 9.71 10 269142 14598 110305549
Gastrointestinal mucosal exfoliation 12.85 9.71 8 269144 255 110319892
Gait disturbance 12.84 9.71 813 268339 277395 110042752
Snoring 12.80 9.71 41 269111 6743 110313404
Peritoneal perforation 12.80 9.71 7 269145 174 110319973
Persecutory delusion 12.78 9.71 39 269113 6252 110313895
Proteinuria 12.77 9.71 52 269100 39966 110280181
Cardiac failure chronic 12.76 9.71 9 269143 13802 110306345
Heart rate decreased 12.69 9.71 277 268875 82479 110237668
Social problem 12.67 9.71 19 269133 1855 110318292
Vaccination complication 12.65 9.71 13 269139 862 110319285
Anaesthesia 12.61 9.71 11 269141 593 110319554
Heparin-induced thrombocytopenia 12.60 9.71 6 269146 11418 110308729
Blood bilirubin increased 12.60 9.71 121 269031 75851 110244296
Ocular hyperaemia 12.57 9.71 51 269101 39235 110280912
Metastases to bone 12.55 9.71 37 269115 31335 110288812
Basal cell carcinoma 12.54 9.71 62 269090 45208 110274939
Cervix haematoma uterine 12.53 9.71 3 269149 4 110320143
Accidental poisoning 12.45 9.71 22 269130 2465 110317682
Resting tremor 12.42 9.71 18 269134 1705 110318442
Poor personal hygiene 12.38 9.71 11 269141 608 110319539
Pleurothotonus 12.37 9.71 22 269130 2476 110317671
Antidepressant drug level below therapeutic 12.36 9.71 4 269148 24 110320123
Bacteraemia 12.35 9.71 57 269095 42333 110277814
Colitis 12.30 9.71 175 268977 102148 110217999
Product dose omission issue 12.24 9.71 649 268503 321133 109999014
Diffuse large B-cell lymphoma stage II 12.24 9.71 6 269146 118 110320029
Haemolysis 12.21 9.71 12 269140 15627 110304520
Myasthenia gravis 12.17 9.71 21 269131 21490 110298657
Pupil fixed 12.08 9.71 28 269124 3810 110316337
Extensor plantar response 12.07 9.71 19 269133 1936 110318211
Bipolar II disorder 12.04 9.71 10 269142 504 110319643
Impaired self-care 11.96 9.71 22 269130 2542 110317605
Vitreous floaters 11.96 9.71 49 269103 9085 110311062
Psychogenic seizure 11.94 9.71 21 269131 2343 110317804
Thrombotic stroke 11.92 9.71 12 269140 776 110319371
Cholestasis 11.91 9.71 100 269052 64418 110255729
Potentiating drug interaction 11.88 9.71 58 269094 11585 110308562
Accommodation disorder 11.87 9.71 11 269141 642 110319505
Slow response to stimuli 11.83 9.71 19 269133 1969 110318178
Hepatotoxicity 11.82 9.71 98 269054 63302 110256845
Akinesia 11.82 9.71 27 269125 3640 110316507
Maternal drugs affecting foetus 11.81 9.71 17 269135 1600 110318547
JC virus CSF test positive 11.80 9.71 7 269145 204 110319943
Coagulation factor increased 11.80 9.71 5 269147 69 110320078
Immune-mediated enterocolitis 11.78 9.71 5 269147 10180 110309967
Gambling disorder 11.77 9.71 20 269132 2171 110317976
Rash vesicular 11.72 9.71 11 269141 14641 110305506
Creatinine renal clearance decreased 11.71 9.71 22 269130 21793 110298354
Neurologic neglect syndrome 11.70 9.71 4 269148 9294 110310853
Illusion 11.69 9.71 19 269133 1988 110318159
Hypocoagulable state 11.65 9.71 22 269130 2593 110317554
Personal relationship issue 11.65 9.71 7 269145 209 110319938
Subarachnoid haemorrhage 11.63 9.71 117 269035 29585 110290562
Hypovitaminosis 11.63 9.71 16 269136 1444 110318703
Systolic hypertension 11.60 9.71 13 269139 951 110319196
Right ventricular failure 11.59 9.71 29 269123 25925 110294222
Lung opacity 11.57 9.71 7 269145 11645 110308502
Exaggerated startle response 11.48 9.71 4 269148 31 110320116
Pickwickian syndrome 11.48 9.71 10 269142 538 110319609
Seizure like phenomena 11.46 9.71 21 269131 2420 110317727
Bulimia nervosa 11.41 9.71 8 269144 312 110319835
Respiratory rate increased 11.41 9.71 102 269050 24981 110295166
Phobia 11.39 9.71 9 269143 422 110319725
Mechanical ventilation 11.38 9.71 25 269127 3282 110316865
Systemic candida 11.38 9.71 5 269147 9969 110310178
Male orgasmic disorder 11.36 9.71 5 269147 76 110320071
Granulocytopenia 11.34 9.71 61 269091 12654 110307493
Nephropathy toxic 11.29 9.71 32 269120 27446 110292701
Agranulocytosis 11.27 9.71 96 269056 61664 110258483
Goitre 11.26 9.71 37 269115 6167 110313980
Overweight 11.25 9.71 38 269114 6426 110313721
Cardiospasm 11.24 9.71 32 269120 4935 110315212
Pulmonary congestion 11.19 9.71 120 269032 30846 110289301
Respiratory alkalosis 11.19 9.71 35 269117 5686 110314461
Acute psychosis 11.16 9.71 32 269120 4955 110315192
Feeling drunk 11.08 9.71 34 269118 5466 110314681
Pleurisy 11.05 9.71 8 269144 12108 110308039
Graft versus host disease in gastrointestinal tract 11.04 9.71 4 269148 8964 110311183
Noninfective encephalitis 11.01 9.71 11 269141 705 110319442
Bundle branch block right 10.99 9.71 59 269093 12232 110307915
Hypertrophic cardiomyopathy 10.99 9.71 24 269128 3139 110317008
Sunburn 10.98 9.71 30 269122 4518 110315629
HIV peripheral neuropathy 10.96 9.71 4 269148 36 110320111
Antisocial behaviour 10.96 9.71 12 269140 856 110319291
Unintentional medical device removal 10.95 9.71 4 269148 8919 110311228
Fear of injection 10.93 9.71 4 269148 8907 110311240
Squamous cell carcinoma of the vulva 10.93 9.71 3 269149 9 110320138
Genito-pelvic pain/penetration disorder 10.93 9.71 3 269149 9 110320138
Anaphylactic reaction 10.92 9.71 204 268948 114096 110206051
Left ventricular hypertrophy 10.79 9.71 62 269090 13182 110306965
Tissue infiltration 10.77 9.71 13 269139 1030 110319117
Carotid artery occlusion 10.75 9.71 49 269103 9516 110310631
Reflexes abnormal 10.73 9.71 13 269139 1034 110319113
Patient elopement 10.73 9.71 8 269144 344 110319803
Coordination abnormal 10.67 9.71 101 269051 25127 110295020
Polydipsia 10.67 9.71 42 269110 7646 110312501
Carbon monoxide poisoning 10.67 9.71 8 269144 347 110319800
Incorrect route of product administration 10.64 9.71 102 269050 63959 110256188
Colostomy closure 10.63 9.71 6 269146 159 110319988
Photosensitivity reaction 10.60 9.71 102 269050 25487 110294660
Drug dispensed to wrong patient 10.60 9.71 11 269141 738 110319409
Inguinal mass 10.58 9.71 7 269145 248 110319899
Drug dose titration not performed 10.56 9.71 13 269139 1052 110319095
Upper gastrointestinal haemorrhage 10.54 9.71 176 268976 49920 110270227
Azoospermia 10.51 9.71 7 269145 251 110319896
Diffuse large B-cell lymphoma 10.46 9.71 14 269138 15884 110304263
Acidosis 10.44 9.71 92 269060 22439 110297708
Renal disorder 10.39 9.71 74 269078 49405 110270742
Tuberculosis 10.38 9.71 17 269135 17757 110302390
Miosis 10.31 9.71 90 269062 21893 110298254
Atrial tachycardia 10.30 9.71 47 269105 9131 110311016
Breast tenderness 10.30 9.71 21 269131 2619 110317528
Blood copper decreased 10.26 9.71 3 269149 12 110320135
Thirst 10.25 9.71 89 269063 21618 110298529
Amniorrhexis 10.25 9.71 4 269148 44 110320103
Hepatitis fulminant 10.23 9.71 4 269148 8556 110311591
Gastrooesophageal reflux disease 10.21 9.71 347 268805 179629 110140518
Treatment noncompliance 10.16 9.71 241 268911 72749 110247398
Respiratory acidosis 10.16 9.71 63 269089 13763 110306384
Hypertransaminasaemia 10.15 9.71 28 269124 24227 110295920
Blood sodium decreased 10.14 9.71 140 269012 38179 110281968
Mutism 10.12 9.71 23 269129 3090 110317057
Borderline personality disorder 10.11 9.71 13 269139 1099 110319048
Hepatitis cholestatic 10.08 9.71 17 269135 17549 110302598
Oesophageal perforation 10.07 9.71 16 269136 1643 110318504
Adrenergic syndrome 10.06 9.71 7 269145 270 110319877
Ejaculation failure 10.04 9.71 8 269144 380 110319767
Osmotic demyelination syndrome 10.00 9.71 18 269134 2045 110318102
Anal sphincter atony 10.00 9.71 9 269143 506 110319641
Rapid eye movements sleep abnormal 9.99 9.71 7 269145 273 110319874
Choking 9.97 9.71 67 269085 15043 110305104
Pneumothorax 9.96 9.71 48 269104 35237 110284910
Apnoea 9.93 9.71 62 269090 13577 110306570
Somatic symptom disorder 9.89 9.71 23 269129 3136 110317011
Neutrophil Pelger-Huet anomaly present 9.88 9.71 8 269144 389 110319758
Inadequate analgesia 9.87 9.71 31 269121 5046 110315101
Asthenopia 9.87 9.71 23 269129 3141 110317006
Contraindicated product prescribed 9.86 9.71 19 269133 2274 110317873
Open reduction of fracture 9.85 9.71 7 269145 279 110319868
Epilepsy 9.84 9.71 178 268974 100031 110220116
Pupillary light reflex tests abnormal 9.81 9.71 8 269144 393 110319754
Ulcer 9.80 9.71 63 269089 43053 110277094
Transient ischaemic attack 9.76 9.71 214 268938 63768 110256379
Urethral haemorrhage 9.76 9.71 9 269143 522 110319625
Personality disorder 9.75 9.71 59 269093 12778 110307369
Judgement impaired 9.74 9.71 14 269138 1316 110318831
Decreased nasolabial fold 9.72 9.71 3 269149 15 110320132
Mini mental status examination abnormal 9.72 9.71 3 269149 15 110320132

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Respiratory disorder neonatal 41.29 30.42 96 1540 2184 110133
Cryptorchism 38.15 30.42 38 1598 384 111933
Periventricular leukomalacia 30.99 30.42 12 1624 12 112305
Small for dates baby 30.76 30.42 119 1517 3621 108696

Pharmacologic Action:

SourceCodeDescription
ATC N06AB04 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:50949 serotonin uptake inhibitor
CHEBI has role CHEBI:53784 antispasmodic drug
CHEBI has role CHEBI:76779 EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
CHEBI has role CHEBI:77402 EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
CHEBI has role CHEBI:78298 environmental contaminant
MeSH PA D000928 Antidepressive Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D017367 Selective Serotonin Reuptake Inhibitors
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018490 Serotonin Agents
MeSH PA D018687 Antidepressive Agents, Second-Generation
MeSH PA D049990 Membrane Transport Modulators
FDA EPC N0000175696 Serotonin Reuptake Inhibitor

Related Drugs by ATC class:

N06AB Selective serotonin reuptake inhibitors 7 drugs
escitaloprametoperidonefluoxetinefluvoxamineparoxetinesertralinezimeldine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Depressive disorder indication 35489007
Major depressive disorder indication 370143000
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Obsessive-compulsive disorder off-label use 191736004 DOID:10933
Menopausal flushing off-label use 198436008
Panic disorder off-label use 371631005 DOID:594
Suicidal thoughts contraindication 6471006
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Torsades de pointes contraindication 31722008
Upper gastrointestinal hemorrhage contraindication 37372002
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Heart disease contraindication 56265001 DOID:114
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Epilepsy contraindication 84757009 DOID:1826
Hyponatremia contraindication 89627008
Prolonged QT interval contraindication 111975006
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Serotonin syndrome contraindication 371089000
Myocardial infarction in recovery phase contraindication 418044006
Poor metabolizer due to cytochrome p450 CYP2C19 variant contraindication 424500005
Congenital long QT syndrome contraindication 442917000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 30MG BASE CITALOPRAM HYDROBROMIDE AUROBINDO PHARMA LTD A219985 March 13, 2026 RX CAPSULE ORAL Sept. 16, 2026 COMPETITIVE GENERIC THERAPY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 8.94 WOMBAT-PK CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.78 DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.40 WOMBAT-PK
Sodium-dependent noradrenaline transporter Transporter Ki 5.21 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 5.19 PDSP
5-hydroxytryptamine receptor 2B GPCR Ki 5.93 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.21 WOMBAT-PK
Histamine H1 receptor GPCR Ki 6.46 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 5.88 PDSP
Sodium-dependent dopamine transporter Transporter Ki 4.78 CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 6.15 DRUG MATRIX
Acetylcholinesterase Enzyme IC50 4.13 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.73 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 5.76 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 5.74 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 8.82 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 5.03 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.54 CHEMBL
Transporter Transporter Ki 5.21 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 8.54 CHEMBL
Transporter Transporter Ki 5.23 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 4.30 CHEMBL
Sigma intracellular receptor 2 Membrane receptor Ki 5.27 CHEMBL

External reference:

IDSource
4021129 VUID
N0000148583 NUI
D00822 KEGG_DRUG
59729-32-7 SECONDARY_CAS_RN
221078 RXNORM
C0008845 UMLSCUI
CHEBI:3723 CHEBI
CHEMBL549 ChEMBL_ID
DB00215 DRUGBANK_ID
CHEMBL1200781 ChEMBL_ID
D015283 MESH_DESCRIPTOR_UI
2771 PUBCHEM_CID
7547 IUPHAR_LIGAND_ID
4138 INN_ID
0DHU5B8D6V UNII
21814 MMSL
62559 MMSL
7486 MMSL
d04332 MMSL
005106 NDDF
005107 NDDF
116521005 SNOMEDCT_US
321986007 SNOMEDCT_US
372596005 SNOMEDCT_US
4021129 VANDF
4021130 VANDF
0DHU5B8D6V INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0054-0062 SOLUTION 10 mg ORAL ANDA 27 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6231 TABLET, FILM COATED 10 mg ORAL ANDA 33 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6232 TABLET, FILM COATED 20 mg ORAL ANDA 33 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6233 TABLET, FILM COATED 40 mg ORAL ANDA 33 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4010 TABLET, FILM COATED 10 mg ORAL NDA 35 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4020 TABLET, FILM COATED 20 mg ORAL NDA 35 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4040 TABLET, FILM COATED 40 mg ORAL NDA 35 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8022 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8023 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8141 TABLET, FILM COATED 40 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0904-6084 TABLET, FILM COATED 10 mg ORAL ANDA 26 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0904-6085 TABLET, FILM COATED 20 mg ORAL ANDA 26 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 10544-006 TABLET 20 mg ORAL ANDA 32 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 10544-149 TABLET 20 mg ORAL ANDA 34 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 10544-150 TABLET 40 mg ORAL ANDA 34 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 10544-179 TABLET, FILM COATED 20 mg ORAL ANDA 25 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 10544-182 TABLET, FILM COATED 40 mg ORAL ANDA 25 sections
Citalopram Hydrobromide HUMAN PRESCRIPTION DRUG LABEL 1 10544-543 TABLET 10 mg ORAL ANDA 25 sections
Citalopram Hydrobromide HUMAN PRESCRIPTION DRUG LABEL 1 12634-023 TABLET 20 mg ORAL ANDA 25 sections
Citalopram Hydrobromide HUMAN PRESCRIPTION DRUG LABEL 1 12634-027 TABLET 40 mg ORAL ANDA 25 sections
Citalopram Hydrobromide HUMAN PRESCRIPTION DRUG LABEL 1 12634-629 TABLET 10 mg ORAL ANDA 25 sections
Citalopram Human Prescription Drug Label 1 13107-005 TABLET 10 mg ORAL ANDA 28 sections
Citalopram Human Prescription Drug Label 1 13107-006 TABLET 20 mg ORAL ANDA 28 sections
Citalopram Human Prescription Drug Label 1 13107-007 TABLET 40 mg ORAL ANDA 28 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 13668-009 TABLET, FILM COATED 10 mg ORAL ANDA 26 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 13668-010 TABLET, FILM COATED 20 mg ORAL ANDA 26 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 13668-011 TABLET, FILM COATED 40 mg ORAL ANDA 26 sections
CITALOPRAM HYDROBROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-055 TABLET 10 mg ORAL ANDA 14 sections
CITALOPRAM HYDROBROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-056 TABLET 20 mg ORAL ANDA 14 sections
CITALOPRAM HYDROBROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-480 TABLET 40 mg ORAL ANDA 14 sections