citalopram Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
663 59729-33-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • citalopram
  • nitalapram
  • bonitrile
  • citalopram hydrobromide
A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.
  • Molecular weight: 324.40
  • Formula: C20H21FN2O
  • CLOGP: 3.13
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 36.26
  • ALOGS: -4.74
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O
20 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.03 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 12 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.64 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 12 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.20 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 33 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 17, 1998 FDA FOREST LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1018.86 9.51 2250 158798 209516 46315498
Completed suicide 1002.22 9.51 1800 159248 144120 46380894
Drug abuse 920.67 9.51 1114 159934 62294 46462720
Serotonin syndrome 533.31 9.51 530 160518 23690 46501324
Electrocardiogram QT prolonged 451.22 9.51 708 160340 50617 46474397
Intentional overdose 410.57 9.51 774 160274 64170 46460844
Overdose 389.47 9.51 992 160056 100987 46424027
Drug interaction 378.10 9.51 1543 159505 201551 46323463
Suicide attempt 341.72 9.51 651 160397 54385 46470629
Sopor 285.16 9.51 347 160701 19481 46505533
Suicidal ideation 278.87 9.51 607 160441 55775 46469239
Intentional self-injury 277.05 9.51 378 160670 23788 46501226
Agitation 245.44 9.51 571 160477 54844 46470170
Anxiety 242.75 9.51 1254 159794 180703 46344311
Drug ineffective 237.73 9.51 1372 159676 676466 45848548
Depression 230.14 9.51 1177 159871 168927 46356087
Treatment failure 172.86 9.51 53 160995 93034 46431980
Poisoning 165.09 9.51 222 160826 13772 46511242
Hyponatraemia 163.52 9.51 738 160310 100594 46424420
Torsade de pointes 160.78 9.51 204 160844 11950 46513064
Respiratory arrest 156.92 9.51 355 160693 33461 46491553
Temperature regulation disorder 153.67 9.51 112 160936 3248 46521766
Panic attack 150.44 9.51 259 160789 19983 46505031
Synovitis 143.70 9.51 20 161028 61055 46463959
Systemic lupus erythematosus 138.64 9.51 28 161020 65152 46459862
Cardio-respiratory arrest 135.83 9.51 485 160563 59384 46465630
Tremor 123.43 9.51 751 160297 114888 46410126
Drug intolerance 117.72 9.51 204 160844 146845 46378169
Off label use 114.91 9.51 803 160245 379038 46145976
Rheumatoid arthritis 114.44 9.51 434 160614 239781 46285233
Pemphigus 113.45 9.51 12 161036 45262 46479752
Mydriasis 110.38 9.51 158 160890 10395 46514619
Akathisia 109.26 9.51 134 160914 7580 46517434
Febrile neutropenia 107.10 9.51 101 160947 94526 46430488
Confusional state 106.30 9.51 927 160121 158965 46366049
Disturbance in attention 101.14 9.51 288 160760 31272 46493742
Hand deformity 98.45 9.51 5 161043 34569 46490445
Electrocardiogram QRS complex prolonged 97.91 9.51 107 160941 5342 46519672
Rash 96.68 9.51 777 160271 355735 46169279
Foetal exposure during pregnancy 94.11 9.51 276 160772 30471 46494543
Accidental overdose 93.46 9.51 211 160837 19855 46505159
Withdrawal syndrome 92.75 9.51 198 160850 17936 46507078
Food allergy 92.70 9.51 117 160931 6816 46518198
Myoclonus 90.51 9.51 171 160877 14181 46510833
Bruxism 87.52 9.51 77 160971 2940 46522074
Anorgasmia 86.64 9.51 42 161006 556 46524458
Cardiac arrest 84.03 9.51 567 160481 89832 46435182
Hyperhidrosis 80.54 9.51 556 160492 88752 46436262
Irritability 80.29 9.51 251 160797 28695 46496319
Coeliac disease 79.02 9.51 110 160938 7051 46517963
Restlessness 78.96 9.51 230 160818 25294 46499720
Alopecia 75.62 9.51 296 160752 162118 46362896
Aggression 75.27 9.51 210 160838 22534 46502480
Depressed mood 73.05 9.51 267 160781 33052 46491962
Pyrexia 71.20 9.51 815 160233 347987 46177027
Seizure 70.40 9.51 691 160357 122363 46402651
Pneumonia 70.09 9.51 897 160151 375423 46149591
Infusion related reaction 70.02 9.51 153 160895 101055 46423959
Unresponsive to stimuli 69.01 9.51 256 160792 31918 46493096
Galactorrhoea 68.99 9.51 75 160973 3722 46521292
Long QT syndrome 68.87 9.51 68 160980 3012 46522002
Drug withdrawal syndrome 67.42 9.51 228 160820 27156 46497858
Interstitial lung disease 66.59 9.51 53 160995 53896 46471118
Somnolence 66.22 9.51 828 160220 155693 46369321
Fall 64.74 9.51 1538 159510 327559 46197455
Extrapyramidal disorder 64.64 9.51 129 160919 11139 46513875
Small for dates baby 64.62 9.51 71 160977 3566 46521448
Self-injurious ideation 59.43 9.51 55 160993 2245 46522769
Obsessive-compulsive disorder 59.28 9.51 64 160984 3151 46521863
Nightmare 58.65 9.51 157 160891 16441 46508573
Neutropenia 58.06 9.51 275 160773 142929 46382085
Joint swelling 57.78 9.51 336 160712 165737 46359277
Therapeutic product effect decreased 57.02 9.51 125 160923 82476 46442538
Exposure via ingestion 57.00 9.51 65 160983 3402 46521612
Infection 56.26 9.51 253 160795 133339 46391675
Muscle twitching 56.17 9.51 143 160905 14529 46510485
Muscle rigidity 55.90 9.51 113 160935 9848 46515166
Rheumatoid factor positive 55.11 9.51 4 161044 20457 46504557
Pericarditis 53.61 9.51 9 161039 23918 46501096
Abdominal discomfort 53.57 9.51 304 160744 150861 46374153
Therapeutic product effect incomplete 52.53 9.51 120 160928 78033 46446981
Arthropathy 51.49 9.51 137 160911 84563 46440451
Pancytopenia 51.39 9.51 138 160910 84920 46440094
Ventricular septal defect 50.66 9.51 66 160982 3968 46521046
Myocardial stunning 50.61 9.51 20 161028 155 46524859
Memory impairment 50.59 9.51 447 160601 76890 46448124
Product prescribing error 50.31 9.51 168 160880 19879 46505135
Malignant neoplasm progression 48.41 9.51 94 160954 64832 46460182
Immunodeficiency 48.38 9.51 126 160922 12980 46512034
Psychomotor hyperactivity 48.05 9.51 104 160944 9509 46515505
Crying 47.68 9.51 171 160877 20970 46504044
Thrombocytopenia 47.34 9.51 250 160798 126331 46398683
Peripheral swelling 47.22 9.51 335 160713 157736 46367278
Mania 47.14 9.51 111 160937 10735 46514279
Intentional product misuse 46.43 9.51 300 160748 46828 46478186
Alcoholism 45.97 9.51 47 161001 2171 46522843
Dyskinesia 45.35 9.51 209 160839 28716 46496298
Contraindicated product administered 45.13 9.51 134 160914 79813 46445201
Disease progression 44.00 9.51 164 160884 91136 46433878
Loss of consciousness 43.37 9.51 567 160481 107671 46417343
Atrial septal defect 43.13 9.51 78 160970 6254 46518760
Depressed level of consciousness 42.77 9.51 296 160752 47273 46477741
Hyperreflexia 42.72 9.51 70 160978 5184 46519830
Coma scale abnormal 42.48 9.51 68 160980 4938 46520076
Hepatic function abnormal 42.24 9.51 34 161014 34387 46490627
Septic shock 42.14 9.51 85 160963 57808 46467206
Psychotic disorder 41.21 9.51 171 160877 22450 46502564
Mood swings 40.60 9.51 136 160912 16116 46508898
Injection site pain 40.41 9.51 211 160837 106941 46418073
Medication error 40.36 9.51 212 160836 30699 46494315
Respiratory disorder neonatal 40.33 9.51 30 161018 898 46524116
Platelet count decreased 39.99 9.51 193 160855 99831 46425183
Illness anxiety disorder 39.63 9.51 16 161032 132 46524882
Disorientation 39.48 9.51 240 160808 36678 46488336
Drug hypersensitivity 39.29 9.51 598 160450 243227 46281787
Bradycardia 38.72 9.51 374 160674 65924 46459090
Impulsive behaviour 38.70 9.51 36 161012 1479 46523535
Haematemesis 38.60 9.51 199 160849 28607 46496407
C-reactive protein increased 38.54 9.51 91 160957 58499 46466515
Loss of libido 38.27 9.51 34 161014 1315 46523699
Posturing 38.26 9.51 23 161025 478 46524536
Cardiac failure congestive 37.87 9.51 175 160873 91575 46433439
Glossodynia 37.85 9.51 59 160989 44314 46480700
Cerebral vasoconstriction 37.48 9.51 30 161018 1003 46524011
Catatonia 37.41 9.51 55 160993 3707 46521307
Cardiac failure 36.35 9.51 147 160901 79801 46445213
C-reactive protein abnormal 36.19 9.51 14 161034 21256 46503758
Inappropriate antidiuretic hormone secretion 36.11 9.51 119 160929 13983 46511031
Generalised tonic-clonic seizure 36.09 9.51 187 160861 26935 46498079
Hallucination 35.44 9.51 294 160754 49657 46475357
Anger 34.93 9.51 105 160943 11747 46513267
Cytomegalovirus infection 34.26 9.51 10 161038 18134 46506880
Mucosal inflammation 34.04 9.51 51 160997 38925 46486089
Congenital thrombocytopenia 33.85 9.51 11 161037 44 46524970
Angle closure glaucoma 33.32 9.51 39 161009 2100 46522914
Libido decreased 33.31 9.51 43 161005 2562 46522452
Arthralgia 33.20 9.51 981 160067 363622 46161392
Alcohol abuse 32.83 9.51 39 161009 2133 46522881
Acute kidney injury 32.57 9.51 595 160453 235260 46289754
Intentional product use issue 32.35 9.51 85 160963 52695 46472319
Palmar-plantar erythrodysaesthesia syndrome 32.33 9.51 15 161033 20436 46504578
Ductus arteriosus premature closure 32.33 9.51 18 161030 322 46524692
Ventricular tachycardia 32.29 9.51 130 160918 16837 46508177
Product use in unapproved indication 32.25 9.51 181 160867 90092 46434922
Suicidal behaviour 32.23 9.51 41 161007 2407 46522607
Lethargy 32.04 9.51 293 160755 50878 46474136
Yawning 31.72 9.51 25 161023 817 46524197
Dyspnoea 30.90 9.51 1459 159589 514089 46010925
Thinking abnormal 30.89 9.51 89 160959 9725 46515289
Bursitis 30.83 9.51 143 160905 19699 46505315
Major depression 30.76 9.51 70 160978 6620 46518394
Dissociation 30.54 9.51 35 161013 1842 46523172
Rabbit syndrome 30.44 9.51 17 161031 306 46524708
Liver disorder 30.38 9.51 51 160997 37195 46487819
Injection site erythema 30.10 9.51 143 160905 74284 46450730
Abnormal behaviour 29.99 9.51 148 160900 20910 46504104
Pulseless electrical activity 29.69 9.51 72 160976 7095 46517919
Bradyphrenia 29.55 9.51 66 160982 6164 46518850
Pneumocystis jirovecii pneumonia 29.54 9.51 8 161040 15240 46509774
Selective eating disorder 29.17 9.51 33 161015 1712 46523302
Bone marrow failure 28.75 9.51 36 161012 29633 46495381
Hypokinesia 28.51 9.51 95 160953 11227 46513787
Antidepressant drug level above therapeutic 28.51 9.51 17 161031 348 46524666
Drug reaction with eosinophilia and systemic symptoms 28.48 9.51 36 161012 29512 46495502
Neuropathy peripheral 28.42 9.51 190 160858 90703 46434311
Maternal exposure during pregnancy 27.91 9.51 223 160825 102326 46422688
Leukopenia 27.81 9.51 131 160917 68212 46456802
Hallucination, auditory 27.75 9.51 91 160957 10665 46514349
Sinusitis 27.65 9.51 300 160748 129468 46395546
Dystonia 27.06 9.51 93 160955 11164 46513850
Drug resistance 27.06 9.51 13 161035 17355 46507659
Amnesia 26.89 9.51 240 160808 41391 46483623
Insomnia 26.83 9.51 752 160296 164172 46360842
Optic ischaemic neuropathy 26.78 9.51 24 161024 939 46524075
Female sexual arousal disorder 26.53 9.51 7 161041 10 46525004
Congenital pulmonary valve atresia 26.42 9.51 10 161038 68 46524946
Personality change 26.41 9.51 57 160991 5201 46519813
Plasma cell myeloma 26.23 9.51 73 160975 44405 46480609
Accidental death 26.19 9.51 32 161016 1803 46523211
Physical assault 25.92 9.51 24 161024 980 46524034
Carcinoid heart disease 25.92 9.51 9 161039 46 46524968
Acute myeloid leukaemia 25.85 9.51 11 161037 15767 46509247
Cataract 25.71 9.51 76 160972 45339 46479675
Sepsis 25.66 9.51 323 160725 135691 46389323
Abnormal dreams 25.66 9.51 86 160962 10193 46514821
Pregnancy 25.66 9.51 171 160877 26966 46498048
Cough 25.53 9.51 602 160446 229647 46295367
Postmortem blood drug level increased 25.42 9.51 17 161031 428 46524586
Histrionic personality disorder 25.31 9.51 9 161039 50 46524964
Disturbance in sexual arousal 25.14 9.51 10 161038 79 46524935
Homicidal ideation 25.03 9.51 31 161017 1771 46523243
Obsessive thoughts 24.96 9.51 18 161030 513 46524501
Apathy 24.93 9.51 68 160980 7200 46517814
Red blood cell sedimentation rate abnormal 24.91 9.51 8 161040 13641 46511373
Aspartate aminotransferase increased 24.86 9.51 164 160884 78536 46446478
Alcohol use 24.71 9.51 36 161012 2406 46522608
Hypotonia neonatal 24.61 9.51 22 161026 858 46524156
Arthritis 24.48 9.51 161 160887 77155 46447859
Injection site reaction 24.34 9.51 84 160964 47765 46477249
Product use issue 24.30 9.51 209 160839 94435 46430579
Product dose omission issue 24.24 9.51 422 160626 168098 46356916
Skin ulcer 24.18 9.51 47 161001 32411 46492603
Pleural effusion 24.16 9.51 177 160871 82775 46442239
Hypochloraemia 24.08 9.51 31 161017 1842 46523172
Brain injury 23.60 9.51 60 160988 6090 46518924
Anaemia 23.54 9.51 687 160361 255092 46269922
Tearfulness 23.31 9.51 47 161001 4088 46520926
Paranoia 23.29 9.51 85 160963 10512 46514502
Hypocoagulable state 23.19 9.51 23 161025 1024 46523990
Renal impairment 22.98 9.51 156 160892 74216 46450798
Cholecystitis chronic 22.89 9.51 84 160964 10415 46514599
Foetal chromosome abnormality 22.84 9.51 7 161041 22 46524992
Toxicologic test abnormal 22.63 9.51 19 161029 680 46524334
Dizziness 22.57 9.51 1411 159637 339003 46186011
Pulmonary arterial hypertension 22.57 9.51 34 161014 25894 46499120
Maternal drugs affecting foetus 22.40 9.51 55 160993 5463 46519551
Cystoid macular oedema 22.27 9.51 27 161021 1509 46523505
Mental disorder 22.23 9.51 143 160905 22282 46502732
Premature delivery 22.20 9.51 26 161022 22043 46502971
Neuropathy, ataxia, retinitis pigmentosa syndrome 21.98 9.51 8 161040 48 46524966
Drug withdrawal syndrome neonatal 21.85 9.51 30 161018 1898 46523116
Negative thoughts 21.84 9.51 20 161028 805 46524209
Adrenal insufficiency 21.74 9.51 9 161039 13115 46511899
Dermatillomania 21.71 9.51 11 161037 161 46524853
Pupillary reflex impaired 21.68 9.51 31 161017 2037 46522977
Rash erythematous 21.66 9.51 197 160851 34153 46490861
Drug eruption 21.60 9.51 25 161023 21304 46503710
Blood creatinine increased 21.32 9.51 165 160883 76238 46448776
Diarrhoea 21.20 9.51 1653 159395 557949 45967065
Adrenergic syndrome 21.16 9.51 7 161041 30 46524984
Alanine aminotransferase increased 21.10 9.51 199 160849 88252 46436762
Cognitive disorder 21 9.51 207 160841 36676 46488338
Blood bilirubin increased 20.99 9.51 55 160993 34129 46490885
Meconium in amniotic fluid 20.96 9.51 11 161037 174 46524840
Panic reaction 20.88 9.51 42 161006 3647 46521367
Calcium deficiency 20.88 9.51 20 161028 853 46524161
Substance abuser 20.86 9.51 6 161042 14 46525000
Talipes 20.83 9.51 25 161023 1382 46523632
Mutism 20.74 9.51 24 161024 1276 46523738
Injection site pruritus 20.74 9.51 69 160979 39674 46485340
Atrial fibrillation 20.68 9.51 243 160805 103347 46421667
Multiple organ dysfunction syndrome 20.52 9.51 100 160948 51610 46473404
Self esteem decreased 20.22 9.51 16 161032 526 46524488
Osteoporosis 20.18 9.51 72 160976 40536 46484478
Herpes zoster 20.16 9.51 144 160904 67728 46457286
Hospitalisation 20.06 9.51 132 160916 63253 46461761
Hyperprolactinaemia 19.82 9.51 36 161012 2896 46522118
Emotional distress 19.82 9.51 177 160871 30530 46494484
Liver function test increased 19.80 9.51 30 161018 22796 46502218
Psoriatic arthropathy 19.79 9.51 62 160986 36317 46488697
Anaphylactic reaction 19.78 9.51 105 160943 53007 46472007
Neonatal hypoxia 19.66 9.51 15 161033 467 46524547
Helicobacter infection 19.52 9.51 8 161040 11728 46513286
Bronchitis 19.49 9.51 253 160795 105726 46419288
Pulmonary valve stenosis congenital 19.40 9.51 10 161038 152 46524862
Wound 19.26 9.51 79 160969 42723 46482291
Osteonecrosis of jaw 19.16 9.51 58 160990 34344 46490670
Renal failure 19.16 9.51 276 160772 113318 46411696
Iris coloboma 19.10 9.51 7 161041 43 46524971
Syncope 19.07 9.51 485 160563 104318 46420696
Injection site swelling 19.05 9.51 73 160975 40254 46484760
Urticaria 19.00 9.51 289 160759 117603 46407411
Infantile apnoea 18.98 9.51 18 161030 758 46524256
Diaphragmatic rupture 18.90 9.51 11 161037 215 46524799
Restless legs syndrome 18.88 9.51 106 160942 15737 46509277
Osmotic demyelination syndrome 18.79 9.51 16 161032 584 46524430
Hyperkinesia 18.76 9.51 27 161021 1785 46523229
Neoplasm progression 18.72 9.51 40 161008 26643 46498371
Sexual inhibition 18.69 9.51 4 161044 0 46525014
Acquired epileptic aphasia 18.69 9.51 4 161044 0 46525014
COVID-19 18.56 9.51 22 161026 18553 46506461
CYP3A4 polymorphism 18.48 9.51 8 161040 80 46524934
Activation syndrome 18.45 9.51 11 161037 225 46524789
Delirium 18.39 9.51 203 160845 37025 46487989
Photosensitivity reaction 18.28 9.51 90 160958 12702 46512312
Abnormal weight gain 18.28 9.51 24 161024 1454 46523560
Localised infection 18.14 9.51 34 161014 23767 46501247
Cerebrospinal fluid retention 18.14 9.51 8 161040 84 46524930
Agonal rhythm 18.08 9.51 6 161042 26 46524988
Panic disorder 18.02 9.51 32 161016 2529 46522485
Atonic urinary bladder 17.97 9.51 8 161040 86 46524928
Infected dermal cyst 17.96 9.51 14 161034 450 46524564
Coma 17.95 9.51 292 160756 58057 46466957
Caput succedaneum 17.91 9.51 5 161043 10 46525004
Non-cardiogenic pulmonary oedema 17.58 9.51 15 161033 549 46524465
Orgasm abnormal 17.57 9.51 8 161040 91 46524923
Tachyphrenia 17.56 9.51 22 161026 1272 46523742
Epilepsy 17.52 9.51 141 160907 23597 46501417
Flat affect 17.50 9.51 22 161026 1276 46523738
No adverse event 17.47 9.51 60 160988 34171 46490843
Bipolar I disorder 17.43 9.51 24 161024 1522 46523492
Vascular access site infection 17.39 9.51 6 161042 30 46524984
Meningitis streptococcal 17.34 9.51 9 161039 139 46524875
Decerebrate posture 17.31 9.51 7 161041 58 46524956
Vascular access site thrombosis 17.23 9.51 6 161042 31 46524983
Amputation stump pain 17.23 9.51 6 161042 31 46524983
Retinal coloboma 17.07 9.51 6 161042 32 46524982
Blood ethanol increased 17.01 9.51 7 161041 61 46524953
Social avoidant behaviour 16.88 9.51 33 161015 2806 46522208
Transplant rejection 16.86 9.51 6 161042 9590 46515424
Antidepressant drug level increased 16.76 9.51 11 161037 268 46524746
Prescribed overdose 16.74 9.51 76 160972 10373 46514641
Hostility 16.66 9.51 22 161026 1340 46523674
Sleep disorder 16.63 9.51 240 160808 46555 46478459
Ventricular fibrillation 16.51 9.51 81 160967 11415 46513599
Tenosynovitis 16.46 9.51 3 161045 7512 46517502
Bradycardia neonatal 16.36 9.51 15 161033 605 46524409
Drug dependence 16.24 9.51 121 160927 19780 46505234
Mood altered 16.15 9.51 88 160960 12919 46512095
Depression suicidal 16.13 9.51 23 161025 1507 46523507
Metastases to bone 16.11 9.51 22 161026 17454 46507560
Pruritus allergic 16.10 9.51 19 161029 1032 46523982
Morbid thoughts 16.06 9.51 14 161034 528 46524486
Parkinsonism 16.01 9.51 62 160986 7886 46517128
Kinematic imbalances due to suboccipital strain 15.93 9.51 4 161044 4 46525010
Hypoxic-ischaemic encephalopathy 15.90 9.51 40 161008 4033 46520981
Nasopharyngitis 15.86 9.51 407 160641 153591 46371423
Nervousness 15.82 9.51 159 160889 28316 46496698
Respiratory tract infection 15.66 9.51 52 160996 29920 46495094
Product substitution issue 15.61 9.51 97 160951 14934 46510080
Pulmonary valve disease 15.59 9.51 5 161043 19 46524995
Renal disorder 15.58 9.51 44 161004 26642 46498372
Duodenal ulcer perforation 15.49 9.51 5 161043 8497 46516517
Drug dose titration not performed 15.36 9.51 12 161036 387 46524627
Hallucinations, mixed 15.24 9.51 38 161010 3811 46521203
Pain 15.17 9.51 1428 159620 475520 46049494
Ocular hyperaemia 15.16 9.51 28 161020 19682 46505332
Skin swelling 15.02 9.51 26 161022 2014 46523000
Metastases to liver 14.90 9.51 28 161020 19557 46505457
Hippocampal sclerosis 14.90 9.51 7 161041 86 46524928
Clonus 14.83 9.51 39 161009 4041 46520973
Haematotoxicity 14.69 9.51 3 161045 6930 46518084
Periventricular leukomalacia 14.69 9.51 7 161041 89 46524925
Unevaluable event 14.69 9.51 96 160952 46079 46478935
Merycism 14.68 9.51 8 161040 137 46524877
Knee arthroplasty 14.58 9.51 38 161010 23627 46501387
White blood cell count decreased 14.58 9.51 286 160762 111945 46413069
Swelling 14.49 9.51 323 160725 124188 46400826
Amniorrhexis 14.49 9.51 5 161043 25 46524989
Stomatitis 14.49 9.51 158 160890 68139 46456875
Post viral fatigue syndrome 14.47 9.51 8 161040 141 46524873
Female orgasmic disorder 14.41 9.51 6 161042 54 46524960
Urethral haemorrhage 14.41 9.51 6 161042 54 46524960
Bronchopulmonary aspergillosis 14.39 9.51 4 161044 7492 46517522
Accommodation disorder 14.37 9.51 11 161037 344 46524670
Toxic epidermal necrolysis 14.33 9.51 35 161013 22243 46502771
Surgery 14.32 9.51 51 160997 28734 46496280
Areflexia 14.31 9.51 32 161016 2991 46522023
Alcohol poisoning 14.27 9.51 27 161021 2241 46522773
Polymenorrhagia 14.22 9.51 6 161042 56 46524958
Hallucination, visual 14.20 9.51 108 160940 17765 46507249
Cardiac steatosis 14.13 9.51 6 161042 57 46524957
Polyhydramnios 14.10 9.51 25 161023 1974 46523040
Chronic kidney disease 14.02 9.51 83 160965 40788 46484226
Antisocial behaviour 13.98 9.51 9 161039 212 46524802
Exposure to allergen 13.90 9.51 8 161040 153 46524861
Dissociative amnesia 13.88 9.51 5 161043 29 46524985
Discomfort 13.87 9.51 99 160949 46571 46478443
Speech disorder 13.86 9.51 188 160860 35979 46489035
Borderline personality disorder 13.82 9.51 15 161033 743 46524271
Ascites 13.80 9.51 72 160976 36512 46488502
Pneumonia viral 13.76 9.51 3 161045 6621 46518393
Dysponesis 13.72 9.51 4 161044 10 46525004
Acute myocardial infarction 13.70 9.51 60 160988 31864 46493150
Rheumatoid nodule 13.68 9.51 7 161041 9013 46516001
Tic 13.66 9.51 19 161029 1217 46523797
Polydipsia 13.65 9.51 33 161015 3246 46521768
Neuroleptic malignant syndrome 13.64 9.51 75 160973 11047 46513967
Fear 13.58 9.51 99 160949 16073 46508941
Periodic limb movement disorder 13.54 9.51 8 161040 161 46524853
Body dysmorphic disorder 13.54 9.51 8 161040 161 46524853
Bradykinesia 13.49 9.51 37 161011 3929 46521085
Indifference 13.49 9.51 7 161041 108 46524906
Vertigo CNS origin 13.47 9.51 5 161043 32 46524982
Neutrophil count decreased 13.45 9.51 91 160957 43335 46481679
Pleurisy 13.39 9.51 5 161043 7757 46517257
Regressive behaviour 13.28 9.51 6 161042 67 46524947
Thrombotic microangiopathy 13.27 9.51 6 161042 8300 46516714
Orthostatic intolerance 13.14 9.51 18 161030 1136 46523878
Therapeutic response decreased 13.07 9.51 91 160957 43054 46481960
Pneumonitis 13.07 9.51 52 160996 28368 46496646
Multiple sclerosis relapse 13.02 9.51 211 160837 41914 46483100
Activated partial thromboplastin time abnormal 12.99 9.51 7 161041 117 46524897
Tardive dyskinesia 12.95 9.51 56 160992 7487 46517527
Increased appetite 12.91 9.51 61 160987 8466 46516548
Aspiration 12.87 9.51 66 160982 9465 46515549
Alcohol interaction 12.85 9.51 27 161021 2418 46522596
Post procedural haematuria 12.85 9.51 5 161043 37 46524977
Pseudomonas infection 12.79 9.51 9 161039 9749 46515265
Tuberculosis 12.77 9.51 10 161038 10255 46514759
Pupil fixed 12.76 9.51 22 161026 1698 46523316
Balance disorder 12.76 9.51 302 160746 64219 46460795
Hyperacusis 12.75 9.51 23 161025 1841 46523173
Peritoneal perforation 12.68 9.51 7 161041 123 46524891
Affective disorder 12.66 9.51 41 161007 4774 46520240
Congenital tricuspid valve incompetence 12.54 9.51 6 161042 77 46524937
Head injury 12.47 9.51 135 160913 24501 46500513
Social problem 12.43 9.51 13 161035 617 46524397
Injection site bruising 12.42 9.51 72 160976 35564 46489450
Coronary artery disease 12.41 9.51 67 160981 33685 46491329
Hypervigilance 12.40 9.51 10 161038 338 46524676
Hepatocellular injury 12.36 9.51 56 160992 29466 46495548
Cerebral ventricular rupture 12.33 9.51 8 161040 191 46524823
Impaired self-care 12.32 9.51 22 161026 1746 46523268
Lung disorder 12.32 9.51 93 160955 43211 46481803
Hypertonic bladder 12.25 9.51 30 161018 2974 46522040
Right ventricular failure 12.25 9.51 23 161025 16070 46508944
Oropharyngeal pain 12.22 9.51 181 160867 73987 46451027
Neutrophil Pelger-Huet anomaly present 12.21 9.51 6 161042 82 46524932
Drug level above therapeutic 12.20 9.51 33 161015 3476 46521538
Apgar score low 12.11 9.51 13 161035 636 46524378
Hypersomnia 12.11 9.51 93 160955 15346 46509668
Akinesia 12.03 9.51 22 161026 1779 46523235
Sensory disturbance 12.02 9.51 78 160970 12189 46512825
Bisexuality 11.95 9.51 3 161045 3 46525011
Cervix haematoma uterine 11.95 9.51 3 161045 3 46525011
Onychogryphosis 11.95 9.51 3 161045 3 46525011
Gestational diabetes 11.94 9.51 53 160995 7166 46517848
Therapy non-responder 11.89 9.51 88 160960 41064 46483950
Postural tremor 11.84 9.51 7 161041 141 46524873
Bipolar II disorder 11.80 9.51 9 161039 280 46524734
Fungal infection 11.76 9.51 57 160991 29463 46495551
Fluid overload 11.72 9.51 51 160997 27134 46497880
Hypertonia 11.72 9.51 38 161010 4428 46520586
Ejection fraction decreased 11.68 9.51 28 161020 17909 46507105
Conversion disorder 11.67 9.51 21 161027 1677 46523337
Myelosuppression 11.65 9.51 6 161042 7697 46517317
Sinus tachycardia 11.60 9.51 120 160928 21529 46503485
Disinhibition 11.59 9.51 15 161033 896 46524118
Psychiatric symptom 11.56 9.51 38 161010 4459 46520555
Pain in extremity 11.56 9.51 753 160295 257927 46267087
Clostridium difficile infection 11.50 9.51 46 161002 25057 46499957
Myocardial fibrosis 11.43 9.51 12 161036 572 46524442
Throat irritation 11.40 9.51 56 160992 28845 46496169
Microphthalmos 11.37 9.51 7 161041 152 46524862
Sexually inappropriate behaviour 11.37 9.51 6 161042 96 46524918
Hypercalcaemia 11.35 9.51 36 161012 21010 46504004
Schizoaffective disorder 11.34 9.51 19 161029 1433 46523581
Hyponatraemic syndrome 11.29 9.51 12 161036 580 46524434
Dysarthria 11.29 9.51 187 160861 37311 46487703
Nail ridging 11.28 9.51 8 161040 222 46524792
Hip arthroplasty 11.22 9.51 29 161019 18083 46506931
Posterior reversible encephalopathy syndrome 11.21 9.51 22 161026 15119 46509895
Trisomy 18 11.13 9.51 5 161043 55 46524959
Hypotonia 11.13 9.51 57 160991 8172 46516842
Somatic symptom disorder 11.10 9.51 22 161026 1890 46523124
Dermatochalasis 11.09 9.51 3 161045 5 46525009
Visual field defect 11.09 9.51 46 161002 6037 46518977
Device expulsion 11.08 9.51 53 160995 27489 46497525
Goitre 11.08 9.51 42 161006 5289 46519725
Myocardial infarction 11.06 9.51 254 160794 97274 46427740
Hyporeflexia 11.02 9.51 22 161026 1900 46523114
Agitation neonatal 11.01 9.51 11 161037 494 46524520
Paraesthesia 11.01 9.51 503 160545 116934 46408080
Eosinophilia 10.99 9.51 32 161016 19185 46505829
Thyroiditis 10.84 9.51 20 161028 1628 46523386
Urine abnormality 10.75 9.51 43 161005 5551 46519463
Congenital megacolon 10.74 9.51 3 161045 6 46525008
Ventricular arrhythmia 10.74 9.51 31 161017 3390 46521624
Hepatotoxicity 10.73 9.51 47 161001 24962 46500052
Circulatory collapse 10.72 9.51 118 160930 21506 46503508
Respiratory alkalosis 10.70 9.51 26 161022 2565 46522449
Procedural anxiety 10.64 9.51 11 161037 515 46524499
Disseminated intravascular coagulation 10.61 9.51 32 161016 18973 46506041
Neutrophil count abnormal 10.57 9.51 25 161023 2425 46522589
Concussion 10.53 9.51 50 160998 6953 46518061
Marital problem 10.51 9.51 7 161041 175 46524839
Red blood cell sedimentation rate increased 10.45 9.51 42 161006 22847 46502167
Phobia 10.44 9.51 9 161039 334 46524680
Tumour lysis syndrome 10.41 9.51 6 161042 7230 46517784
Sebaceous gland infection 10.36 9.51 6 161042 116 46524898
Ophthalmoplegia 10.36 9.51 14 161034 872 46524142
Blood osmolarity decreased 10.33 9.51 13 161035 755 46524259
Carcinoid syndrome 10.32 9.51 6 161042 117 46524897
Therapy cessation 10.28 9.51 52 160996 26577 46498437
Gastrointestinal sounds abnormal 10.27 9.51 31 161017 3475 46521539
Oromandibular dystonia 10.26 9.51 10 161038 436 46524578
Drug level increased 10.25 9.51 103 160945 18338 46506676
Umbilical artery vascular resistance increased 10.24 9.51 4 161044 30 46524984
Neonatal sinus tachycardia 10.24 9.51 4 161044 30 46524984
Depressive symptom 10.19 9.51 27 161021 2809 46522205
Narcolepsy 10.19 9.51 16 161032 1143 46523871
Antisocial personality disorder 10.15 9.51 3 161045 8 46525006
Respiratory disorder 10.15 9.51 54 160994 27246 46497768
Analgesic drug level above therapeutic 10.14 9.51 7 161041 186 46524828
Blunted affect 10.10 9.51 7 161041 187 46524827
Vaginal discharge 10.09 9.51 38 161010 4770 46520244
Blood urea increased 10.07 9.51 49 160999 25303 46499711
Accidental exposure to product 10.06 9.51 38 161010 21043 46503971
Fibromyalgia 10.05 9.51 79 160969 36384 46488630
Anaphylactic shock 10.03 9.51 36 161012 20238 46504776
Choanal atresia 10.01 9.51 4 161044 32 46524982
Opiates positive 10.01 9.51 8 161040 267 46524747
Agoraphobia 9.98 9.51 9 161039 355 46524659
Cleft lip and palate 9.98 9.51 9 161039 355 46524659
Hypocalcaemia 9.94 9.51 53 160995 26732 46498282
Impaired healing 9.94 9.51 80 160968 36663 46488351
Facial paralysis 9.94 9.51 79 160969 13171 46511843
Respiratory tract congestion 9.93 9.51 18 161030 12746 46512268
Dry mouth 9.93 9.51 254 160794 54672 46470342
Oral neoplasm benign 9.89 9.51 3 161045 9 46525005
Rash maculo-papular 9.89 9.51 56 160992 27818 46497196
Psychomotor retardation 9.87 9.51 29 161019 3204 46521810
Myelodysplastic syndrome 9.86 9.51 25 161023 15686 46509328
Rhabdomyolysis 9.82 9.51 201 160847 41708 46483306
Gastrooesophageal reflux disease 9.79 9.51 189 160859 74155 46450859
Incoherent 9.75 9.51 36 161012 4476 46520538
Hypoglycaemia 9.73 9.51 251 160797 54098 46470916
Sleep disorder due to general medical condition, insomnia type 9.72 9.51 3 161045 5246 46519768
Antipsychotic drug level above therapeutic 9.71 9.51 14 161034 927 46524087
Ureteric dilatation 9.70 9.51 4 161044 35 46524979
Blood copper decreased 9.65 9.51 3 161045 10 46525004
Miosis 9.63 9.51 47 161001 6610 46518404
Pulmonary valve incompetence 9.60 9.51 17 161031 1341 46523673
Biliary dyskinesia 9.56 9.51 26 161022 2747 46522267
Epistaxis 9.56 9.51 160 160888 64145 46460869
Acute generalised exanthematous pustulosis 9.55 9.51 11 161037 9394 46515620
Nystagmus 9.54 9.51 42 161006 5657 46519357
Tendonitis 9.52 9.51 22 161026 14255 46510759
Poor feeding infant 9.51 9.51 7 161041 206 46524808
Congenital coronary artery malformation 9.51 9.51 4 161044 37 46524977

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 886.61 10.61 1194 77506 98298 29775480
Toxicity to various agents 715.63 10.61 1490 77210 175693 29698085
Serotonin syndrome 485.05 10.61 391 78309 17500 29856278
Drug abuse 463.98 10.61 798 77902 81274 29792504
Intentional overdose 280.92 10.61 438 78262 41043 29832735
Suicidal ideation 268.10 10.61 398 78302 35716 29838062
Overdose 254.08 10.61 633 78067 83704 29790074
Depression 211.23 10.61 618 78082 89819 29783959
Anxiety 176.29 10.61 578 78122 89293 29784485
Suicide attempt 172.79 10.61 330 78370 36367 29837411
Drug interaction 170.08 10.61 998 77702 198570 29675208
Foetal exposure during pregnancy 168.01 10.61 327 78373 36544 29837234
Respiratory disorder neonatal 147.76 10.61 69 78631 1119 29872659
Electrocardiogram QT prolonged 146.75 10.61 304 78396 35531 29838247
Intentional self-injury 144.39 10.61 178 78522 13354 29860424
Poisoning 118.67 10.61 148 78552 11234 29862544
Febrile neutropenia 109.39 10.61 73 78627 106620 29767158
Restlessness 106.05 10.61 203 78497 22396 29851382
Obsessive-compulsive disorder 104.79 10.61 87 78613 4054 29869724
Psychotic disorder 104.35 10.61 196 78504 21319 29852459
Drug withdrawal syndrome neonatal 102.50 10.61 77 78623 3098 29870680
Disinhibition 100.02 10.61 63 78637 1894 29871884
Pyrexia 99.18 10.61 418 78282 294071 29579707
Neonatal respiratory distress syndrome 98.85 10.61 83 78617 3929 29869849
Agitation neonatal 98.77 10.61 50 78650 975 29872803
Hypertonia neonatal 95.58 10.61 36 78664 328 29873450
Respiratory arrest 90.44 10.61 222 78478 29036 29844742
Aggression 88.67 10.61 255 78445 36652 29837126
Agitation 87.88 10.61 327 78373 53746 29820032
Atrial septal defect 81.10 10.61 94 78606 6607 29867171
Disturbance in attention 80.52 10.61 179 78521 21950 29851828
Tremor 78.82 10.61 399 78301 74964 29798814
Antipsychotic drug level below therapeutic 77.31 10.61 47 78653 1325 29872453
Off label use 76.53 10.61 366 78334 248924 29624854
Paranoia 75.12 10.61 112 78588 10076 29863702
Erectile dysfunction 72.23 10.61 152 78548 17950 29855828
Pneumonia 71.12 10.61 551 78149 333755 29540023
Depressed mood 70.30 10.61 145 78555 16884 29856894
Irritability 70.28 10.61 174 78526 22876 29850902
Confusional state 68.67 10.61 596 78104 134238 29739540
Tearfulness 68.38 10.61 46 78654 1550 29872228
Small for dates baby 66.21 10.61 60 78640 3148 29870630
Sexual dysfunction 65.72 10.61 80 78620 5921 29867857
Asphyxia 65.48 10.61 76 78624 5349 29868429
Cryptorchism 63.98 10.61 45 78655 1632 29872146
Hepatic function abnormal 59.65 10.61 18 78682 41927 29831851
Maternal drugs affecting foetus 58.64 10.61 64 78636 4209 29869569
Neonatal seizure 56.99 10.61 27 78673 453 29873325
Intentional product misuse 55.75 10.61 209 78491 34458 29839320
Interstitial lung disease 55.44 10.61 46 78654 60151 29813627
Hypospadias 55.08 10.61 50 78650 2629 29871149
Muscle twitching 54.97 10.61 86 78614 8069 29865709
Akathisia 54.05 10.61 72 78628 5832 29867946
Acute kidney injury 53.27 10.61 462 78238 273380 29600398
Depression suicidal 52.82 10.61 36 78664 1240 29872538
Cardio-respiratory arrest 52.76 10.61 293 78407 57013 29816765
Diarrhoea 52.35 10.61 594 78106 333509 29540269
Somnambulism 50.98 10.61 52 78648 3162 29870616
Panic attack 50.97 10.61 86 78614 8595 29865183
Prescription drug used without a prescription 50.80 10.61 35 78665 1227 29872551
Exposure during pregnancy 50.77 10.61 89 78611 9172 29864606
Therapeutic product effect variable 50.06 10.61 36 78664 1353 29872425
Mental impairment 49.37 10.61 88 78612 9189 29864589
Homicide 49.31 10.61 32 78668 1014 29872764
Increased appetite 49.14 10.61 67 78633 5550 29868228
Mydriasis 48.86 10.61 70 78630 6073 29867705
Euphoric mood 48.30 10.61 58 78642 4232 29869546
Bradycardia neonatal 48.10 10.61 30 78670 886 29872892
Loss of libido 47.75 10.61 41 78659 2001 29871777
Cytomegalovirus infection 47.25 10.61 4 78696 23670 29850108
Depressive symptom 46.77 10.61 37 78663 1608 29872170
Malignant neoplasm progression 46.27 10.61 74 78626 72213 29801565
Sepsis 45.95 10.61 213 78487 146182 29727596
Septic shock 45.74 10.61 60 78640 63547 29810231
Fall 44.64 10.61 698 78002 181174 29692604
Renal failure 44.51 10.61 181 78519 128785 29744993
Muscle rigidity 44.27 10.61 89 78611 10172 29863606
Rheumatoid arthritis 43.80 10.61 27 78673 41170 29832608
Coma scale abnormal 43.63 10.61 49 78651 3327 29870451
Logorrhoea 43.08 10.61 39 78661 2043 29871735
Drug screen positive 42.29 10.61 55 78645 4352 29869426
Anger 41.63 10.61 91 78609 11029 29862749
Platelet count decreased 41.14 10.61 142 78558 105987 29767791
Temperature regulation disorder 40.83 10.61 22 78678 490 29873288
Libido decreased 40.76 10.61 55 78645 4511 29869267
Haemangioma congenital 40.27 10.61 22 78678 504 29873274
Cardiac failure 39.25 10.61 102 78598 83316 29790462
Somnolence 38.89 10.61 407 78293 96356 29777422
Congenital ureteropelvic junction obstruction 38.32 10.61 12 78688 58 29873720
Psychiatric decompensation 38.30 10.61 30 78670 1285 29872493
Depressed level of consciousness 38.27 10.61 200 78500 38022 29835756
Hyperreflexia 38.05 10.61 42 78658 2797 29870981
Product use in unapproved indication 37.10 10.61 87 78613 73606 29800172
Hyperhidrosis 36.96 10.61 302 78398 66788 29806990
Multiple organ dysfunction syndrome 36.96 10.61 69 78631 63418 29810360
Hypomania 36.69 10.61 37 78663 2219 29871559
Drug withdrawal syndrome 36.60 10.61 125 78575 19684 29854094
Hallucination, auditory 36.52 10.61 80 78620 9709 29864069
Sopor 35.66 10.61 85 78615 10906 29862872
Hanging 35.56 10.61 13 78687 108 29873670
Sedation 35.38 10.61 109 78591 16264 29857514
Newborn persistent pulmonary hypertension 35.10 10.61 12 78688 80 29873698
Hallucination 34.50 10.61 234 78466 48825 29824953
Withdrawal syndrome 34.36 10.61 85 78615 11165 29862613
Orgasmic sensation decreased 34.28 10.61 10 78690 36 29873742
Drug reaction with eosinophilia and systemic symptoms 34.19 10.61 16 78684 28472 29845306
Tardive dyskinesia 33.62 10.61 53 78647 5004 29868774
Derealisation 33.57 10.61 20 78680 543 29873235
Inappropriate antidiuretic hormone secretion 33.52 10.61 85 78615 11337 29862441
Foot deformity 33.14 10.61 43 78657 3394 29870384
Bipolar disorder 32.97 10.61 45 78655 3731 29870047
Electrocardiogram QRS complex prolonged 32.94 10.61 48 78652 4229 29869549
Negative thoughts 32.23 10.61 21 78679 670 29873108
Mania 32.12 10.61 73 78627 9081 29864697
Apgar score low 32.04 10.61 23 78677 862 29872916
Drug resistance 31.76 10.61 7 78693 20126 29853652
Renal impairment 31.70 10.61 114 78586 84070 29789708
Alcohol use 31.66 10.61 44 78656 3711 29870067
Psychomotor hyperactivity 31.58 10.61 68 78632 8156 29865622
Drug ineffective 31.46 10.61 669 78031 339718 29534060
Psychomotor skills impaired 31.35 10.61 32 78668 1947 29871831
Patent ductus arteriosus 31.11 10.61 40 78660 3129 29870649
Anaemia 30.84 10.61 374 78326 207618 29666160
Atrial fibrillation 30.63 10.61 163 78537 107961 29765817
Apathy 30.48 10.61 57 78643 6175 29867603
Gun shot wound 29.96 10.61 25 78675 1173 29872605
Hyperbilirubinaemia neonatal 29.83 10.61 20 78680 670 29873108
Optic nerve hypoplasia 29.67 10.61 6 78694 0 29873778
Congenital hepatomegaly 29.59 10.61 8 78692 20 29873758
Mental disorder 29.50 10.61 90 78610 13359 29860419
Myocardial infarction 29.48 10.61 201 78499 125424 29748354
Pleural effusion 29.44 10.61 98 78602 73968 29799810
Stomatitis 29.08 10.61 33 78667 37246 29836532
Myocardial fibrosis 29.03 10.61 20 78680 701 29873077
Oesophageal perforation 28.71 10.61 17 78683 456 29873322
Loss of consciousness 28.71 10.61 327 78373 79048 29794730
Obesity 28.67 10.61 67 78633 8488 29865290
Cardiac arrest 28.58 10.61 371 78329 92479 29781299
Congenital pulmonary hypertension 28.49 10.61 9 78691 45 29873733
Dyskinesia 28.21 10.61 123 78577 21711 29852067
Spontaneous penile erection 27.83 10.61 13 78687 211 29873567
Nightmare 27.60 10.61 82 78618 11994 29861784
Respiratory failure 27.25 10.61 154 78546 100488 29773290
Pancytopenia 27.09 10.61 123 78577 84929 29788849
Toxicologic test abnormal 27.06 10.61 18 78682 595 29873183
Anorgasmia 27.01 10.61 18 78682 597 29873181
Circulatory collapse 26.98 10.61 115 78585 20099 29853679
Neonatal pneumonia 26.75 10.61 10 78690 89 29873689
Disturbance in sexual arousal 26.75 10.61 11 78689 129 29873649
Postmortem blood drug level increased 26.75 10.61 11 78689 129 29873649
Neutropenia 26.65 10.61 213 78487 128327 29745451
Accidental death 26.57 10.61 30 78670 2049 29871729
Major depression 26.53 10.61 42 78658 3980 29869798
Tremor neonatal 26.35 10.61 15 78685 373 29873405
Impulsive behaviour 26.21 10.61 29 78671 1936 29871842
Mucosal inflammation 26.03 10.61 25 78675 30469 29843309
Oedema peripheral 26 10.61 167 78533 105665 29768113
Disseminated intravascular coagulation 25.77 10.61 13 78687 22158 29851620
Disease progression 25.75 10.61 115 78585 79759 29794019
Limb deformity 25.70 10.61 16 78684 471 29873307
Heat stroke 25.67 10.61 20 78680 850 29872928
Congenital central nervous system anomaly 25.65 10.61 15 78685 393 29873385
Hand deformity 25.61 10.61 28 78672 1845 29871933
Amnesia 25.55 10.61 129 78571 24192 29849586
Radiologically isolated syndrome 25.52 10.61 6 78694 6 29873772
Prescribed overdose 25.43 10.61 64 78636 8497 29865281
Infection 25.41 10.61 112 78588 77962 29795816
Poverty of speech 25.40 10.61 12 78688 200 29873578
Brain oedema 25.37 10.61 81 78619 12317 29861461
Infantile apnoea 25.29 10.61 20 78680 869 29872909
Decreased appetite 25.18 10.61 262 78438 149648 29724130
Psychomotor retardation 24.89 10.61 31 78669 2348 29871430
Neuropathy peripheral 24.86 10.61 98 78602 70377 29803401
Torsade de pointes 24.85 10.61 57 78643 7133 29866645
Cough 24.77 10.61 211 78489 125431 29748347
Congenital hypercoagulation 24.72 10.61 5 78695 0 29873778
Conduction disorder 24.67 10.61 28 78672 1923 29871855
Panic reaction 24.36 10.61 24 78676 1399 29872379
Asthma 24.12 10.61 36 78664 36138 29837640
Homicidal ideation 24.04 10.61 31 78669 2432 29871346
Hypoglycaemia neonatal 24 10.61 25 78675 1558 29872220
Clonus 23.86 10.61 31 78669 2450 29871328
Thrombocytopenia 23.63 10.61 238 78462 136806 29736972
Antipsychotic drug level increased 23.61 10.61 35 78665 3131 29870647
Hospitalisation 23.37 10.61 51 78649 44268 29829510
Impaired work ability 23.22 10.61 48 78652 5595 29868183
Congenital hydronephrosis 23.15 10.61 17 78683 660 29873118
Opiates positive 22.82 10.61 12 78688 254 29873524
Oedema 22.24 10.61 50 78650 42943 29830835
Tic 22.10 10.61 27 78673 2005 29871773
Neonatal infection 22 10.61 12 78688 274 29873504
Gender dysphoria 21.84 10.61 7 78693 37 29873741
Dyspnoea 21.72 10.61 689 78011 332606 29541172
Pneumocystis jirovecii pneumonia 21.51 10.61 9 78691 17111 29856667
Dreamy state 21.40 10.61 6 78694 18 29873760
Genital hypoaesthesia 21.15 10.61 10 78690 167 29873611
Agoraphobia 21.08 10.61 11 78689 229 29873549
Hallucination, visual 20.99 10.61 91 78609 16022 29857756
Bladder trabeculation 20.80 10.61 5 78695 6 29873772
Pneumonitis 20.66 10.61 25 78675 27429 29846349
Dyslipidaemia 20.46 10.61 46 78654 5681 29868097
Victim of chemical submission 20.43 10.61 7 78693 47 29873731
Acute myocardial infarction 20.38 10.61 71 78629 52868 29820910
Parkinsonism 20.20 10.61 53 78647 7216 29866562
Kinematic imbalances due to suboccipital strain 20.07 10.61 6 78694 24 29873754
Dysphemia 20.00 10.61 22 78678 1459 29872319
Maternal exposure during breast feeding 19.92 10.61 23 78677 1609 29872169
Drug-induced liver injury 19.89 10.61 16 78684 21258 29852520
Hyperbilirubinaemia 19.59 10.61 10 78690 16932 29856846
Myoclonus 19.55 10.61 78 78622 13234 29860544
Seizure 19.40 10.61 365 78335 98110 29775668
Lung disorder 19.39 10.61 33 78667 31436 29842342
Mental status changes 19.39 10.61 165 78535 36914 29836864
Selective eating disorder 19.34 10.61 23 78677 1661 29872117
Pilonidal cyst congenital 19.33 10.61 6 78694 28 29873750
Periventricular leukomalacia 19.33 10.61 6 78694 28 29873750
Anhidrosis 19.29 10.61 8 78692 96 29873682
Tachycardia 19.18 10.61 286 78414 73453 29800325
Hypertonia 18.87 10.61 38 78662 4347 29869431
Peritonitis 18.86 10.61 17 78683 21358 29852420
Poor feeding infant 18.81 10.61 12 78688 369 29873409
Blood creatinine increased 18.65 10.61 152 78548 91223 29782555
Persistent foetal circulation 18.61 10.61 12 78688 376 29873402
Mood swings 18.60 10.61 53 78647 7573 29866205
Bone marrow failure 18.57 10.61 31 78669 29754 29844024
Drug hypersensitivity 18.46 10.61 105 78595 68414 29805364
Blood alcohol increased 18.41 10.61 17 78683 914 29872864
Vestibular disorder 18.36 10.61 16 78684 797 29872981
C-reactive protein increased 18.33 10.61 56 78644 43417 29830361
Ventricular septal defect 18.17 10.61 33 78667 3496 29870282
Lactic acidosis 18.09 10.61 34 78666 31179 29842599
Choanal atresia 18.08 10.61 5 78695 14 29873764
Hyponatraemic syndrome 18.08 10.61 10 78690 235 29873543
Premature ejaculation 18.06 10.61 8 78692 114 29873664
Hyponatraemia 18.01 10.61 262 78438 66940 29806838
Suicidal behaviour 18.00 10.61 20 78680 1342 29872436
Unresponsive to stimuli 17.96 10.61 125 78575 26294 29847484
Eosinophilia 17.96 10.61 19 78681 22141 29851637
Bronchopulmonary aspergillosis 17.96 10.61 5 78695 12279 29861499
Blood bilirubin increased 17.83 10.61 44 78656 36592 29837186
Interstitial granulomatous dermatitis 17.71 10.61 9 78691 177 29873601
Rash 17.70 10.61 377 78323 191512 29682266
Duodenal ulcer perforation 17.63 10.61 22 78678 1670 29872108
Acute myeloid leukaemia 17.53 10.61 13 78687 17993 29855785
Jaundice 17.44 10.61 37 78663 32449 29841329
Decreased interest 17.44 10.61 25 78675 2170 29871608
Osteonecrosis of jaw 17.41 10.61 14 78686 18604 29855174
Vasoplegia syndrome 17.38 10.61 19 78681 1252 29872526
Peripheral swelling 17.32 10.61 92 78608 60982 29812796
Substance abuse 17.24 10.61 49 78651 6991 29866787
Incontinence 17.07 10.61 41 78659 5285 29868493
Slow response to stimuli 17.01 10.61 15 78685 759 29873019
Cyanosis neonatal 16.93 10.61 10 78690 267 29873511
Facial spasm 16.72 10.61 9 78691 200 29873578
Tachyphrenia 16.59 10.61 17 78683 1039 29872739
Disorientation 16.52 10.61 140 78560 31278 29842500
Hypertrophic cardiomyopathy 16.47 10.61 16 78684 917 29872861
Drug dependence 16.44 10.61 104 78596 21191 29852587
Poor quality sleep 16.39 10.61 49 78651 7192 29866586
Xanthoma 16.38 10.61 7 78693 91 29873687
Infantile vomiting 16.35 10.61 5 78695 22 29873756
Constipation 16.32 10.61 204 78496 112702 29761076
Haemophagocytic lymphohistiocytosis 16.28 10.61 3 78697 9788 29863990
Pulmonary oedema 16.27 10.61 182 78518 43793 29829985
Synovitis 16.26 10.61 3 78697 9780 29863998
Arachnoid cyst 16.21 10.61 9 78691 213 29873565
Acute stress disorder 16.18 10.61 8 78692 148 29873630
Memory impairment 16.17 10.61 159 78541 37015 29836763
Spermatozoa morphology abnormal 16.13 10.61 4 78696 6 29873772
Blood catecholamines decreased 16.13 10.61 4 78696 6 29873772
Coordination abnormal 16.12 10.61 49 78651 7256 29866522
Epistaxis 16.05 10.61 78 78622 52903 29820875
Generalised tonic-clonic seizure 16.04 10.61 97 78603 19454 29854324
Cleft lip and palate 16.01 10.61 10 78690 296 29873482
Opisthotonus 15.93 10.61 11 78689 387 29873391
JC virus CSF test positive 15.91 10.61 7 78693 98 29873680
Scleroderma renal crisis 15.91 10.61 7 78693 98 29873680
Granulocytopenia 15.90 10.61 44 78656 6182 29867596
Brugada syndrome 15.85 10.61 13 78687 595 29873183
Rectourethral fistula 15.83 10.61 5 78695 25 29873753
Hydrocele 15.83 10.61 23 78677 2021 29871757
Accidental poisoning 15.77 10.61 12 78688 492 29873286
Ventricular flutter 15.71 10.61 6 78694 57 29873721
Parkinson's disease 15.70 10.61 21 78679 1707 29872071
Cardiac failure congestive 15.63 10.61 144 78556 84263 29789515
Congenital pneumonia 15.60 10.61 7 78693 103 29873675
Haemoglobin decreased 15.45 10.61 209 78491 113889 29759889
Haematuria 15.39 10.61 63 78637 44771 29829007
Thrombosis 15.35 10.61 58 78642 42173 29831605
Myelodysplastic syndrome 15.33 10.61 16 78684 18762 29855016
Economic problem 15.27 10.61 19 78681 1438 29872340
Pleurothotonus 15.23 10.61 16 78684 1007 29872771
Caesarean section 15.05 10.61 23 78677 2114 29871664
Lymphoma 15.02 10.61 4 78696 10117 29863661
Hypercalcaemia 15.02 10.61 7 78693 12488 29861290
Liver disorder 15.02 10.61 35 78665 29687 29844091
Nasopharyngitis 14.88 10.61 92 78608 58757 29815021
Morbid thoughts 14.86 10.61 9 78691 252 29873526
Holoprosencephaly 14.83 10.61 3 78697 0 29873778
Epilepsy congenital 14.83 10.61 3 78697 0 29873778
Hypertrophic scar 14.79 10.61 4 78696 10 29873768
Libido disorder 14.76 10.61 9 78691 255 29873523
Physical assault 14.65 10.61 17 78683 1196 29872582
Cytokine release syndrome 14.60 10.61 4 78696 9929 29863849
Hepatitis C virus test positive 14.57 10.61 11 78689 446 29873332
Osmolar gap abnormal 14.42 10.61 5 78695 35 29873743
Tumour lysis syndrome 14.32 10.61 8 78692 12877 29860901
Intrusive thoughts 14.25 10.61 6 78694 75 29873703
Hepatic failure 14.24 10.61 44 78656 33999 29839779
Thrombotic stroke 14.24 10.61 9 78691 272 29873506
Executive dysfunction 14.23 10.61 7 78693 128 29873650
Psychiatric symptom 14.21 10.61 29 78671 3350 29870428
Exposure via ingestion 14.19 10.61 25 78675 2586 29871192
Inguinal mass 14.06 10.61 5 78695 38 29873740
Micropenis 14.06 10.61 5 78695 38 29873740
Anomaly of external ear congenital 14.04 10.61 7 78693 132 29873646
Teratogenicity 13.95 10.61 5 78695 39 29873739
Toxic epidermal necrolysis 13.86 10.61 16 78684 17924 29855854
Dissociation 13.84 10.61 16 78684 1121 29872657
Plasma cell myeloma 13.82 10.61 83 78617 53379 29820399
Social avoidant behaviour 13.77 10.61 26 78674 2837 29870941
Hepatocellular injury 13.68 10.61 29 78671 25442 29848336
Influenza 13.67 10.61 63 78637 43335 29830443
Staphylococcal sepsis 13.62 10.61 4 78696 9487 29864291
Blood urea increased 13.53 10.61 40 78660 31341 29842437
Iron binding capacity total increased 13.53 10.61 5 78695 43 29873735
Dystonia 13.49 10.61 56 78644 9671 29864107
Renal disorder 13.39 10.61 26 78674 23558 29850220
Abnormal behaviour 13.38 10.61 114 78586 25509 29848269
Salivary hypersecretion 13.33 10.61 47 78653 7519 29866259
Infusion related reaction 13.31 10.61 58 78642 40506 29833272
Personality change 13.26 10.61 34 78666 4566 29869212
Male orgasmic disorder 13.15 10.61 6 78694 92 29873686
Diffuse large B-cell lymphoma stage II 13.14 10.61 5 78695 47 29873731
Head circumference abnormal 13.14 10.61 5 78695 47 29873731
Testicular atrophy 13.13 10.61 11 78689 519 29873259
Radicular pain 13.09 10.61 6 78694 93 29873685
Thinking abnormal 13.04 10.61 37 78663 5274 29868504
Urticaria 12.97 10.61 87 78613 54519 29819259
Neonatal disorder 12.93 10.61 14 78686 912 29872866
Antipsychotic drug level above therapeutic 12.93 10.61 15 78685 1055 29872723
Neonatal hypoxia 12.80 10.61 8 78692 237 29873541
Seizure like phenomena 12.77 10.61 11 78689 539 29873239
Gas poisoning 12.76 10.61 3 78697 3 29873775
Adjusted calcium increased 12.66 10.61 4 78696 20 29873758
Yawning 12.65 10.61 11 78689 546 29873232
Intentional product use issue 12.64 10.61 51 78649 36389 29837389
Dysarthria 12.58 10.61 129 78571 30361 29843417
Congenital hydrocephalus 12.54 10.61 6 78694 103 29873675
Feeling abnormal 12.45 10.61 214 78486 56542 29817236
Activation syndrome 12.44 10.61 6 78694 105 29873673
Poor personal hygiene 12.37 10.61 8 78692 252 29873526
Muscle mass 12.23 10.61 8 78692 257 29873521
Congenital hand malformation 12.23 10.61 10 78690 456 29873322
Renal vasculitis 12.18 10.61 6 78694 110 29873668
Rhinitis perennial 12.14 10.61 6 78694 111 29873667
Limb reduction defect 12.09 10.61 7 78693 180 29873598
Colitis 12.08 10.61 41 78659 30779 29842999
Chondrodystrophy 12.06 10.61 4 78696 24 29873754
Pulmonary valve stenosis 12.02 10.61 9 78691 360 29873418
Toxic skin eruption 12.01 10.61 7 78693 11008 29862770
Personality disorder 12.00 10.61 15 78685 1140 29872638
Carbon monoxide poisoning 11.90 10.61 6 78694 116 29873662
Angle closure glaucoma 11.87 10.61 12 78688 722 29873056
Infertility 11.78 10.61 7 78693 189 29873589
CSF test abnormal 11.75 10.61 7 78693 190 29873588
Crystalluria 11.73 10.61 9 78691 374 29873404
Alcoholism 11.72 10.61 27 78673 3387 29870391
Coagulation factor VII level decreased 11.71 10.61 6 78694 120 29873658
COVID-19 11.71 10.61 18 78682 17860 29855918
Haematospermia 11.68 10.61 9 78691 376 29873402
Blunted affect 11.62 10.61 8 78692 280 29873498
Priapism 11.60 10.61 33 78667 4710 29869068
Alcoholic psychosis 11.55 10.61 3 78697 6 29873772
Drug therapy enhancement 11.55 10.61 3 78697 6 29873772
Pulmonary arterial hypertension 11.51 10.61 5 78695 9296 29864482
Coagulation factor increased 11.50 10.61 5 78695 68 29873710
Delusion 11.49 10.61 62 78638 11927 29861851
CSF white blood cell count positive 11.41 10.61 4 78696 29 29873749
Pulmonary artery stenosis congenital 11.39 10.61 10 78690 503 29873275
Pulmonary embolism 11.35 10.61 141 78559 77994 29795784
Cerebral vasoconstriction 11.28 10.61 7 78693 205 29873573
Weight increased 11.27 10.61 267 78433 74646 29799132
Self-medication 11.24 10.61 21 78679 2273 29871505
Feeling guilty 11.23 10.61 8 78692 296 29873482
Wrong product administered 11.17 10.61 32 78668 4586 29869192
Erythema 11.16 10.61 140 78560 77311 29796467
Bacterial infection 11.16 10.61 10 78690 12600 29861178
Cognitive disorder 11.13 10.61 103 78597 23587 29850191
Kidney transplant rejection 11.08 10.61 3 78697 7506 29866272
Tobacco user 10.98 10.61 10 78690 528 29873250
Drug level above therapeutic 10.94 10.61 24 78676 2915 29870863
Electrocardiogram QT interval abnormal 10.94 10.61 5 78695 77 29873701
Cytopenia 10.93 10.61 4 78696 8252 29865526
Coronary artery disease 10.93 10.61 81 78619 49631 29824147
External auditory canal atresia 10.92 10.61 6 78694 139 29873639
Product administered to patient of inappropriate age 10.90 10.61 22 78678 2521 29871257
Diabetic foetopathy 10.86 10.61 7 78693 219 29873559
Drug level increased 10.85 10.61 84 78616 18270 29855508
Post-traumatic stress disorder 10.84 10.61 17 78683 1598 29872180
Hyperuricaemia 10.83 10.61 3 78697 7391 29866387
Dissociative amnesia 10.82 10.61 5 78695 79 29873699
Dyspnoea exertional 10.82 10.61 52 78648 35378 29838400
Arthropathy 10.80 10.61 24 78676 20703 29853075
Transaminases increased 10.78 10.61 29 78671 23428 29850350
Angioedema 10.77 10.61 50 78650 34334 29839444
Urinary retention 10.74 10.61 133 78567 32784 29840994
Affect lability 10.62 10.61 26 78674 3392 29870386

Pharmacologic Action:

SourceCodeDescription
ATC N06AB04 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
FDA EPC N0000175696 Serotonin Reuptake Inhibitor
CHEBI has role CHEBI:35469 thymoanaleptics
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:50949 serotonin reuptake inhibitor
CHEBI has role CHEBI:76779 prolyl oligopeptidase (ec 3.4.21.26) inhibitor
CHEBI has role CHEBI:77402 trypanothione reductase inhibitors
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D000928 Antidepressive Agents
MeSH PA D018687 Antidepressive Agents, Second-Generation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D017367 Serotonin Uptake Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Depressive disorder indication 35489007
Major depressive disorder indication 370143000
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Obsessive-compulsive disorder off-label use 191736004 DOID:10933
Menopausal flushing off-label use 198436008
Panic disorder off-label use 371631005 DOID:594
Suicidal thoughts contraindication 6471006
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Torsades de pointes contraindication 31722008
Upper gastrointestinal hemorrhage contraindication 37372002
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Heart disease contraindication 56265001 DOID:114
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Epilepsy contraindication 84757009 DOID:1826
Hyponatremia contraindication 89627008
Prolonged QT interval contraindication 111975006
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Serotonin syndrome contraindication 371089000
Myocardial infarction in recovery phase contraindication 418044006
Poor metabolizer due to cytochrome p450 CYP2C19 variant contraindication 424500005
Congenital long QT syndrome contraindication 442917000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 8.94 WOMBAT-PK CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.78 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 5.93 DRUG MATRIX
Alpha-1D adrenergic receptor GPCR Ki 6.15 DRUG MATRIX
Solute carrier family 22 member 1 Transporter IC50 4.73 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 5.21 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 6.21 WOMBAT-PK
Histamine H1 receptor GPCR Ki 6.46 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.40 WOMBAT-PK
Sodium-dependent dopamine transporter Transporter Ki 4.78 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 5.19 PDSP
Muscarinic acetylcholine receptor M1 GPCR Ki 5.88 PDSP
Alpha-1B adrenergic receptor GPCR Ki 5.74 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 8.82 CHEMBL
Transporter Transporter Ki 5.23 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 8.54 CHEMBL
Transporter Transporter Ki 5.21 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 5.03 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 4.30 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 5.76 CHEMBL

External reference:

IDSource
4021129 VUID
N0000148583 NUI
D00822 KEGG_DRUG
59729-32-7 SECONDARY_CAS_RN
4021129 VANDF
4021130 VANDF
C0008845 UMLSCUI
CHEBI:3723 CHEBI
CHEMBL549 ChEMBL_ID
CHEMBL399730 ChEMBL_ID
CHEMBL1200781 ChEMBL_ID
DB00215 DRUGBANK_ID
D015283 MESH_DESCRIPTOR_UI
2771 PUBCHEM_CID
7547 IUPHAR_LIGAND_ID
4138 INN_ID
0DHU5B8D6V UNII
221078 RXNORM
21814 MMSL
62559 MMSL
7486 MMSL
d04332 MMSL
005106 NDDF
005107 NDDF
116521005 SNOMEDCT_US
321986007 SNOMEDCT_US
372596005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 53808-0226 TABLET, FILM COATED 20 mg ORAL ANDA 20 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 53808-0647 TABLET, FILM COATED 40 mg ORAL ANDA 20 sections