citalopram 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
663 59729-33-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • citalopram
  • nitalapram
  • bonitrile
  • citalopram hydrobromide
A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.
  • Molecular weight: 324.40
  • Formula: C20H21FN2O
  • CLOGP: 3.13
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 36.26
  • ALOGS: -4.74
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O
20 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.03 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 12 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.64 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 12 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.20 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 33 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 17, 1998 FDA FOREST LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1220.36 9.41 1874 175068 130015 50298167
Toxicity to various agents 1146.01 9.41 2384 174558 210115 50218067
Drug abuse 989.01 9.41 1131 175811 58715 50369467
Serotonin syndrome 573.59 9.41 560 176382 24153 50404029
Electrocardiogram QT prolonged 557.68 9.41 792 176150 51094 50377088
Drug interaction 460.63 9.41 1639 175303 197982 50230200
Overdose 455.34 9.41 1048 175894 98679 50329503
Intentional overdose 438.22 9.41 785 176157 61719 50366463
Systemic lupus erythematosus 372.86 9.41 32 176910 140590 50287592
Pemphigus 365.97 9.41 12 176930 120154 50308028
Suicide attempt 361.66 9.41 649 176293 51083 50377099
Drug ineffective 361.50 9.41 1560 175382 817773 49610409
Synovitis 352.08 9.41 20 176922 123845 50304337
Hand deformity 324.44 9.41 5 176937 100194 50327988
Sopor 316.76 9.41 369 176573 19510 50408672
Suicidal ideation 300.30 9.41 624 176318 54761 50373421
Agitation 283.07 9.41 596 176346 52788 50375394
Treatment failure 278.72 9.41 69 176873 137568 50290614
Intentional self-injury 244.05 9.41 350 176592 22762 50405420
Drug intolerance 239.15 9.41 248 176694 218856 50209326
Hyponatraemia 238.28 9.41 809 176133 95330 50332852
Pericarditis 235.56 9.41 9 176933 78680 50349502
Glossodynia 229.99 9.41 60 176882 115509 50312673
Alopecia 223.45 9.41 319 176623 244728 50183454
Anti-cyclic citrullinated peptide antibody positive 222.48 9.41 5 176937 70582 50357600
Torsade de pointes 216.37 9.41 236 176706 11599 50416583
Temperature regulation disorder 205.51 9.41 147 176795 4080 50424102
Anxiety 203.91 9.41 1187 175755 176419 50251763
Respiratory arrest 201.41 9.41 370 176572 29639 50398543
Infusion related reaction 196.41 9.41 182 176760 169375 50258807
Arthropathy 189.47 9.41 164 176778 157742 50270440
Cardio-respiratory arrest 188.51 9.41 512 176430 53380 50374802
Poisoning 186.88 9.41 224 176718 12205 50415977
Abdominal discomfort 171.98 9.41 344 176598 231297 50196885
Rash 169.94 9.41 870 176072 436601 49991581
Tremor 168.72 9.41 822 176120 114081 50314101
Off label use 167.56 9.41 974 175968 473452 49954730
Therapeutic product effect decreased 159.94 9.41 144 176798 135906 50292276
Wound 158.67 9.41 86 176856 105708 50322474
Rheumatoid factor positive 155.32 9.41 4 176938 49855 50378327
Contraindicated product administered 153.14 9.41 177 176765 148781 50279401
Panic attack 152.50 9.41 256 176686 19086 50409096
Joint swelling 152.39 9.41 401 176541 244885 50183297
Helicobacter infection 141.24 9.41 8 176934 49694 50378488
Hyperhidrosis 137.20 9.41 648 176294 88778 50339404
Duodenal ulcer perforation 133.87 9.41 6 176936 45605 50382577
Food allergy 129.53 9.41 151 176791 7986 50420196
Discomfort 125.83 9.41 116 176826 108264 50319918
Cardiac arrest 125.30 9.41 602 176340 83049 50345133
Foetal exposure during pregnancy 118.63 9.41 282 176660 27077 50401105
Mydriasis 112.27 9.41 161 176781 10466 50417716
Swelling 111.04 9.41 347 176595 200525 50227657
Akathisia 110.32 9.41 140 176802 8089 50420093
Infection 110.21 9.41 279 176663 172675 50255507
Coeliac disease 108.98 9.41 143 176799 8542 50419640
Disturbance in attention 108.73 9.41 296 176646 30890 50397292
Fall 106.59 9.41 1703 175239 333229 50094953
Somnolence 106.08 9.41 914 176028 154071 50274111
Accidental overdose 105.71 9.41 220 176722 19313 50408869
Myoclonus 105.50 9.41 185 176757 14285 50413897
Muscle injury 105.36 9.41 6 176936 37105 50391077
Withdrawal syndrome 103.36 9.41 205 176737 17385 50410797
Bruxism 102.36 9.41 85 176857 2955 50425227
Irritability 102.32 9.41 273 176669 28153 50400029
Electrocardiogram QRS complex prolonged 101.94 9.41 109 176833 5235 50422947
Maternal exposure during pregnancy 101.59 9.41 258 176684 159520 50268662
Depression 101.17 9.41 952 175990 164471 50263711
Febrile neutropenia 97.18 9.41 119 176823 97548 50330634
Seizure 96.33 9.41 724 176218 117150 50311032
Sleep disorder due to general medical condition, insomnia type 96.18 9.41 3 176939 31444 50396738
Restlessness 94.93 9.41 246 176696 24927 50403255
Peripheral swelling 94.33 9.41 385 176557 205551 50222631
Folliculitis 91.25 9.41 14 176928 39211 50388971
Unresponsive to stimuli 90.68 9.41 274 176668 30335 50397847
Drug withdrawal syndrome 89.38 9.41 240 176702 24841 50403341
Anorgasmia 89.08 9.41 42 176900 513 50427669
Aggression 88.69 9.41 215 176727 20901 50407281
Product use issue 82.71 9.41 258 176684 149217 50278965
Confusional state 79.78 9.41 997 175945 184931 50243251
Nightmare 75.43 9.41 171 176771 15915 50412267
Long QT syndrome 74.03 9.41 70 176872 2897 50425285
Pyrexia 73.83 9.41 913 176029 379290 50048892
Sinusitis 73.68 9.41 326 176616 170232 50257950
Impaired healing 72.66 9.41 82 176860 69704 50358478
Immunodeficiency 72.18 9.41 160 176782 14668 50413514
Muscle twitching 71.20 9.41 163 176779 15268 50412914
Loss of consciousness 69.56 9.41 612 176330 103741 50324441
Galactorrhoea 69.37 9.41 75 176867 3648 50424534
Irritable bowel syndrome 68.51 9.41 48 176894 51393 50376789
Muscle rigidity 68.22 9.41 123 176819 9706 50418476
Exposure via ingestion 67.79 9.41 65 176877 2738 50425444
Small for dates baby 67.76 9.41 72 176870 3433 50424749
Blister 65.75 9.41 124 176818 85294 50342888
Alcoholism 64.56 9.41 50 176892 1570 50426612
Intentional product use issue 64.33 9.41 106 176836 76812 50351370
Memory impairment 63.42 9.41 485 176457 78875 50349307
Extrapyramidal disorder 61.86 9.41 131 176811 11639 50416543
Dyskinesia 60.81 9.41 225 176717 27636 50400546
Self-injurious ideation 60.27 9.41 55 176887 2174 50426008
Stomatitis 59.58 9.41 170 176772 101174 50327008
Ill-defined disorder 59.36 9.41 62 176880 54592 50373590
Mania 56.80 9.41 121 176821 10795 50417387
Interstitial lung disease 55.88 9.41 62 176880 53114 50375068
Hallucination 54.81 9.41 314 176628 46343 50381839
Depressed mood 54.68 9.41 250 176692 33773 50394409
Arthralgia 54.53 9.41 1145 175797 437557 49990625
Crying 54.24 9.41 176 176766 20240 50407942
Malignant neoplasm progression 54.11 9.41 97 176845 68027 50360155
Yawning 53.71 9.41 36 176906 897 50427285
Disorientation 53.55 9.41 256 176686 35228 50392954
Dizziness 52.68 9.41 1584 175358 344785 50083397
C-reactive protein increased 52.49 9.41 95 176847 66379 50361803
C-reactive protein abnormal 52.38 9.41 16 176926 27793 50400389
Myocardial stunning 52.21 9.41 20 176922 139 50428043
Hepatic enzyme increased 52.09 9.41 275 176667 137105 50291077
Rash erythematous 51.55 9.41 250 176692 34602 50393580
Obsessive-compulsive disorder 51.53 9.41 61 176881 3279 50424903
Coma scale abnormal 51.45 9.41 73 176869 4698 50423484
Haematemesis 50.87 9.41 212 176730 27513 50400669
Psychomotor hyperactivity 50.60 9.41 105 176837 9196 50418986
Neutropenia 50.27 9.41 307 176635 147658 50280524
Inappropriate antidiuretic hormone secretion 50.12 9.41 129 176813 13014 50415168
Pancytopenia 50.10 9.41 140 176802 83890 50344292
Ventricular septal defect 49.87 9.41 66 176876 3975 50424207
Intentional product misuse 49.43 9.41 306 176636 46428 50381754
Bradycardia 49.40 9.41 390 176552 64036 50364146
Bursitis 48.51 9.41 179 176763 21956 50406226
Pain 48.43 9.41 1600 175342 577303 49850879
Pneumonia 48.06 9.41 984 175958 377417 50050765
Hyperreflexia 47.54 9.41 73 176869 5045 50423137
Psychotic disorder 47.48 9.41 176 176766 21636 50406546
Product prescribing error 47.19 9.41 171 176771 20790 50407392
Parkinsonism 47.11 9.41 99 176843 8748 50419434
Medication error 47.10 9.41 250 176692 35854 50392328
Accidental death 45.15 9.41 42 176900 1702 50426480
Rheumatic fever 44.22 9.41 4 176938 16863 50411319
Depressed level of consciousness 44.04 9.41 322 176620 51631 50376551
Nasopharyngitis 43.36 9.41 448 176494 192479 50235703
Loss of libido 42.86 9.41 35 176907 1188 50426994
Atrial septal defect 42.30 9.41 78 176864 6263 50421919
Lethargy 42.26 9.41 307 176635 49125 50379057
Generalised tonic-clonic seizure 42.03 9.41 193 176749 26117 50402065
Pulseless electrical activity 41.73 9.41 81 176861 6760 50421422
Illness anxiety disorder 41.31 9.41 16 176926 115 50428067
Drug dependence 40.99 9.41 157 176785 19602 50408580
Cerebral vasoconstriction 40.37 9.41 31 176911 961 50427221
Alcohol abuse 40.25 9.41 41 176901 1860 50426322
Anger 39.93 9.41 108 176834 11225 50416957
Septic shock 39.74 9.41 88 176854 57087 50371095
Thrombocytopenia 39.74 9.41 272 176670 127401 50300781
Hip arthroplasty 39.72 9.41 29 176913 30400 50397782
Respiratory disorder neonatal 39.60 9.41 30 176912 911 50427271
Drug withdrawal syndrome neonatal 39.51 9.41 40 176902 1801 50426381
Impulsive behaviour 39.47 9.41 36 176906 1422 50426760
Mood swings 39.23 9.41 134 176808 15820 50412362
Ventricular tachycardia 39.01 9.41 133 176809 15688 50412494
Posturing 38.84 9.41 23 176919 458 50427724
Antidepressant drug level above therapeutic 38.14 9.41 21 176921 362 50427820
Bradyphrenia 37.72 9.41 73 176869 6079 50422103
Product use in unapproved indication 37.42 9.41 244 176698 115575 50312607
Disease progression 37.40 9.41 190 176752 95676 50332506
Calcium deficiency 37.16 9.41 29 176913 921 50427261
Catatonia 37.13 9.41 55 176887 3681 50424501
Nicotine dependence 37.05 9.41 25 176917 630 50427552
Hypokinesia 36.78 9.41 110 176832 12107 50416075
Hepatic function abnormal 36.71 9.41 36 176906 32645 50395537
Libido decreased 36.00 9.41 43 176899 2333 50425849
Therapeutic product effect incomplete 35.91 9.41 181 176761 91334 50336848
Thinking abnormal 35.56 9.41 93 176849 9474 50418708
Red blood cell sedimentation rate abnormal 35.45 9.41 7 176935 16336 50411846
Hypersensitivity 35.42 9.41 534 176408 214627 50213555
Mucosal inflammation 34.80 9.41 54 176888 40088 50388094
Syncope 34.62 9.41 529 176413 102473 50325709
Angle closure glaucoma 34.49 9.41 39 176903 1995 50426187
Cytomegalovirus infection 34.44 9.41 10 176932 17952 50410230
Injection site pain 34.31 9.41 237 176705 110787 50317395
Abnormal behaviour 34.26 9.41 148 176794 19510 50408672
Knee arthroplasty 34.26 9.41 45 176897 35801 50392381
Congenital thrombocytopenia 33.71 9.41 11 176931 44 50428138
Abnormal dreams 33.68 9.41 90 176852 9287 50418895
Suicidal behaviour 33.35 9.41 41 176901 2293 50425889
Ductus arteriosus premature closure 32.81 9.41 18 176924 308 50427874
Panic reaction 31.88 9.41 50 176892 3519 50424663
Carcinoid heart disease 31.79 9.41 9 176933 19 50428163
Apathy 30.78 9.41 76 176866 7472 50420710
Liver disorder 30.46 9.41 52 176890 37170 50391012
Rabbit syndrome 30.38 9.41 17 176925 303 50427879
Platelet count decreased 30.16 9.41 217 176725 100509 50327673
Alcohol use 30.06 9.41 36 176906 1959 50426223
Hostility 29.93 9.41 34 176908 1748 50426434
Hyperprolactinaemia 29.86 9.41 47 176895 3318 50424864
Stiff person syndrome 29.63 9.41 15 176927 216 50427966
Insomnia 29.35 9.41 810 176132 174055 50254127
Rheumatoid arthritis 29.25 9.41 515 176427 202035 50226147
COVID-19 29.12 9.41 76 176866 46586 50381596
Hallucination, auditory 28.96 9.41 93 176849 10635 50417547
Disturbance in sexual arousal 28.90 9.41 11 176931 75 50428107
Hypochloraemia 28.64 9.41 32 176910 1615 50426567
Dyspnoea 28.43 9.41 1596 175346 546012 49882170
Pneumocystis jirovecii pneumonia 28.41 9.41 8 176934 14655 50413527
Female sexual arousal disorder 28.30 9.41 7 176935 6 50428176
Psoriatic arthropathy 28.29 9.41 78 176864 46954 50381228
Brain injury 28.27 9.41 64 176878 5950 50422232
Tearfulness 28.00 9.41 48 176894 3639 50424543
Arthritis 27.85 9.41 183 176759 86538 50341644
Physical assault 27.72 9.41 24 176918 884 50427298
Hypoglycaemia 27.69 9.41 298 176644 53283 50374899
Drug eruption 27.69 9.41 25 176917 23581 50404601
Drug resistance 27.63 9.41 16 176926 18973 50409209
Dissociation 27.63 9.41 37 176905 2254 50425928
Selective eating disorder 27.51 9.41 33 176909 1799 50426383
Dystonia 27.45 9.41 98 176844 11828 50416354
Paranoia 27.30 9.41 89 176853 10259 50417923
Injection site erythema 27.28 9.41 152 176790 74784 50353398
Bradykinesia 26.93 9.41 49 176893 3894 50424288
Hyperkinesia 26.61 9.41 29 176913 1423 50426759
Toxicologic test abnormal 26.52 9.41 20 176922 603 50427579
Palmar-plantar erythrodysaesthesia syndrome 26.43 9.41 19 176923 20079 50408103
Tenosynovitis 26.41 9.41 3 176939 10562 50417620
Alcohol poisoning 26.33 9.41 32 176910 1768 50426414
Congenital pulmonary valve atresia 26.29 9.41 10 176932 68 50428114
Cholecystitis chronic 26.27 9.41 84 176858 9585 50418597
Leukopenia 26.24 9.41 134 176808 67394 50360788
Emotional distress 26.23 9.41 181 176761 28482 50399700
Amnesia 26.17 9.41 244 176698 42016 50386166
Homicidal ideation 26.12 9.41 31 176911 1671 50426511
Post viral fatigue syndrome 25.86 9.41 15 176927 287 50427895
Macular degeneration 25.82 9.41 9 176933 14379 50413803
Injection site reaction 25.81 9.41 89 176853 49943 50378239
Skin ulcer 25.67 9.41 53 176889 35265 50392917
Major depression 25.67 9.41 67 176875 6817 50421365
Flat affect 25.57 9.41 27 176915 1278 50426904
Premature delivery 25.51 9.41 27 176915 23636 50404546
Obsessive thoughts 25.43 9.41 18 176924 491 50427691
Optic ischaemic neuropathy 25.38 9.41 24 176918 993 50427189
Ventricular fibrillation 25.36 9.41 88 176854 10471 50417711
Hypocoagulable state 25.12 9.41 23 176919 913 50427269
Product dose omission issue 25.10 9.41 472 176470 183366 50244816
Bone marrow failure 25.07 9.41 36 176906 27588 50400594
Myelosuppression 25.06 9.41 8 176934 13509 50414673
Histrionic personality disorder 25.04 9.41 9 176933 51 50428131
Ventricular arrhythmia 25.02 9.41 43 176899 3266 50424916
Maternal drugs affecting foetus 24.95 9.41 55 176887 5022 50423160
Rheumatoid nodule 24.58 9.41 7 176935 12728 50415454
Sputum purulent 24.56 9.41 23 176919 940 50427242
Mutism 24.30 9.41 27 176915 1354 50426828
Cardiac failure congestive 24.20 9.41 184 176758 84198 50343984
Secondary immunodeficiency 24.03 9.41 25 176917 1163 50427019
Cystoid macular oedema 24.02 9.41 27 176915 1372 50426810
Lower respiratory tract infection 23.93 9.41 215 176727 94986 50333196
Epilepsy 23.93 9.41 143 176799 21424 50406758
Mental disorder 23.88 9.41 145 176797 21846 50406336
Cataract 23.83 9.41 85 176857 47215 50380967
Pupillary reflex impaired 23.64 9.41 31 176911 1850 50426332
Speech disorder 23.41 9.41 208 176734 35340 50392842
Delirium 23.39 9.41 220 176722 37972 50390210
Condition aggravated 23.33 9.41 827 176115 296231 50131951
Foetal chromosome abnormality 23.24 9.41 7 176935 20 50428162
Personality change 23.19 9.41 57 176885 5588 50422594
Photosensitivity reaction 23.11 9.41 98 176844 12813 50415369
Blood cholesterol increased 22.93 9.41 107 176835 55108 50373074
Restless legs syndrome 22.77 9.41 113 176829 15784 50412398
Dermatillomania 22.66 9.41 11 176931 144 50428038
Infantile apnoea 22.55 9.41 21 176921 852 50427330
Drug hypersensitivity 22.50 9.41 687 176255 250323 50177859
Hypotonia 22.40 9.41 71 176871 8063 50420119
Concussion 22.32 9.41 68 176874 7560 50420622
Bipolar I disorder 22.23 9.41 27 176915 1491 50426691
Adrenal insufficiency 22.19 9.41 11 176931 14232 50413950
Goitre 22.16 9.41 54 176888 5266 50422916
Pruritus 22.14 9.41 790 176152 282778 50145404
Pregnancy 22.09 9.41 178 176764 29399 50398783
Nervousness 22.08 9.41 169 176773 27482 50400700
Hypotonia neonatal 22.02 9.41 22 176920 975 50427207
Neuropathy peripheral 21.99 9.41 224 176718 96533 50331649
Neuropathy, ataxia, retinitis pigmentosa syndrome 21.88 9.41 8 176934 48 50428134
Potentiating drug interaction 21.85 9.41 44 176898 3772 50424410
Asthma 21.80 9.41 436 176506 88901 50339281
Cardiac failure 21.71 9.41 166 176776 75874 50352308
Liver function test increased 21.67 9.41 35 176907 25571 50402611
Pruritus allergic 21.64 9.41 23 176919 1097 50427085
Acute myeloid leukaemia 21.51 9.41 13 176929 15061 50413121
Rib deformity 21.51 9.41 11 176931 162 50428020
Hospitalisation 21.49 9.41 144 176798 67793 50360389
Sinus tachycardia 21.44 9.41 138 176804 21216 50406966
Libido increased 21.36 9.41 24 176918 1219 50426963
Tachyphrenia 21.33 9.41 24 176918 1221 50426961
Postmortem blood drug level increased 21.12 9.41 17 176925 565 50427617
Adrenergic syndrome 21.07 9.41 7 176935 30 50428152
Coma 21.01 9.41 297 176645 56582 50371600
Neoplasm progression 20.99 9.41 44 176898 29113 50399069
Negative thoughts 20.79 9.41 20 176922 846 50427336
Substance abuser 20.78 9.41 6 176936 14 50428168
Fibromyalgia 20.60 9.41 84 176858 44894 50383288
Localised infection 20.49 9.41 36 176906 25449 50402733
Neonatal respiratory depression 20.48 9.41 8 176934 59 50428123
Hypoxic-ischaemic encephalopathy 20.46 9.41 43 176899 3799 50424383
Talipes 20.46 9.41 25 176917 1389 50426793
Musculoskeletal stiffness 20.39 9.41 321 176621 128160 50300022
Vascular access site infection 20.20 9.41 7 176935 35 50428147
Gastrointestinal disorder 20.12 9.41 222 176720 94234 50333948
Aspartate aminotransferase increased 20.11 9.41 175 176767 77823 50350359
Vascular access site thrombosis 20.04 9.41 7 176935 36 50428146
Diaphragmatic rupture 19.92 9.41 12 176930 247 50427935
Antidepressant drug level increased 19.83 9.41 12 176930 249 50427933
Pulmonary valve stenosis congenital 19.82 9.41 10 176932 143 50428039
Urticaria 19.80 9.41 326 176616 129235 50298947
Injection site swelling 19.78 9.41 77 176865 41696 50386486
Hallucination, visual 19.73 9.41 112 176830 16470 50411712
Drug tolerance decreased 19.71 9.41 4 176938 9156 50419026
Activation syndrome 19.56 9.41 11 176931 198 50427984
Product substitution issue 19.48 9.41 99 176843 13958 50414224
Hypertonia 19.48 9.41 43 176899 3930 50424252
Neonatal hypoxia 19.45 9.41 15 176927 468 50427714
Iris coloboma 19.43 9.41 7 176935 40 50428142
Basal ganglion degeneration 19.40 9.41 14 176928 394 50427788
Self esteem decreased 19.35 9.41 16 176926 553 50427629
Cognitive disorder 19.04 9.41 237 176705 43886 50384296
Dementia 19.00 9.41 108 176834 15889 50412293
Bronchomalacia 18.94 9.41 11 176931 211 50427971
Post-traumatic neck syndrome 18.81 9.41 28 176914 1882 50426300
Facial paralysis 18.65 9.41 91 176851 12624 50415558
Sexual inhibition 18.64 9.41 4 176938 0 50428182
Acquired epileptic aphasia 18.64 9.41 4 176938 0 50428182
Osmotic demyelination syndrome 18.61 9.41 16 176926 584 50427598
Agonal rhythm 18.58 9.41 6 176936 23 50428159
Dysarthria 18.39 9.41 206 176736 37197 50390985
CYP3A4 polymorphism 18.37 9.41 8 176934 80 50428102
Chronic spontaneous urticaria 18.37 9.41 15 176927 509 50427673
Abnormal weight gain 18.36 9.41 24 176918 1428 50426754
Orgasm abnormal 18.29 9.41 8 176934 81 50428101
Cerebrospinal fluid retention 18.29 9.41 8 176934 81 50428101
Atonic urinary bladder 18.20 9.41 8 176934 82 50428100
Urinary retention 18.16 9.41 155 176787 26035 50402147
Acute kidney injury 18.10 9.41 634 176308 227424 50200758
Infected dermal cyst 18.07 9.41 14 176928 440 50427742
Haematotoxicity 17.95 9.41 3 176939 7892 50420290
Caput succedaneum 17.84 9.41 5 176937 10 50428172
Fear 17.79 9.41 99 176843 14450 50413732
CFTR gene mutation 17.79 9.41 8 176934 87 50428095
Gestational diabetes 17.74 9.41 62 176880 7403 50420779
Alcohol interaction 17.73 9.41 29 176913 2115 50426067
Meconium in amniotic fluid 17.73 9.41 11 176931 239 50427943
Herpes zoster 17.73 9.41 160 176782 70626 50357556
Head injury 17.64 9.41 144 176798 23876 50404306
Panic disorder 17.51 9.41 30 176912 2273 50425909
Bipolar II disorder 17.34 9.41 11 176931 249 50427933
Transplant rejection 17.26 9.41 6 176936 9603 50418579
Amputation stump pain 17.15 9.41 6 176936 31 50428151
Alanine aminotransferase increased 17.14 9.41 212 176730 88147 50340035
Areflexia 17.06 9.41 33 176909 2747 50425435
Mood altered 17.04 9.41 89 176853 12684 50415498
Non-cardiogenic pulmonary oedema 17.02 9.41 15 176927 566 50427616
Retinal coloboma 16.99 9.41 6 176936 32 50428150
Clonus 16.99 9.41 42 176900 4133 50424049
Injection site pruritus 16.97 9.41 78 176864 40333 50387849
Anaemia 16.92 9.41 716 176226 251740 50176442
Social avoidant behaviour 16.92 9.41 33 176909 2764 50425418
Meningitis streptococcal 16.89 9.41 9 176933 145 50428037
Lipoedema 16.84 9.41 11 176931 262 50427920
Cardiac steatosis 16.84 9.41 6 176936 33 50428149
Metastases to bone 16.78 9.41 23 176919 17972 50410210
Labelled drug-drug interaction issue 16.77 9.41 11 176931 264 50427918
Social problem 16.66 9.41 17 176925 773 50427409
Periventricular leukomalacia 16.62 9.41 7 176935 64 50428118
Hypokalaemia 16.59 9.41 414 176528 87578 50340604
Metastases to liver 16.53 9.41 28 176914 20076 50408106
Sternal fracture 16.45 9.41 27 176915 1975 50426207
Respiratory disorder 16.41 9.41 55 176887 31132 50397050
Pleural effusion 16.34 9.41 194 176748 81260 50346922
Polyhydramnios 16.22 9.41 27 176915 1998 50426184
Renal impairment 16.04 9.41 178 176764 75483 50352699
Depression suicidal 15.91 9.41 23 176919 1506 50426676
Morbid thoughts 15.89 9.41 14 176928 528 50427654
Kinematic imbalances due to suboccipital strain 15.88 9.41 4 176938 4 50428178
Panniculitis 15.82 9.41 5 176937 8498 50419684
Decerebrate posture 15.82 9.41 8 176934 115 50428067
Multiple organ dysfunction syndrome 15.77 9.41 107 176835 50230 50377952
Multiple sclerosis relapse 15.73 9.41 224 176718 42740 50385442
Rhabdomyolysis 15.73 9.41 207 176735 38820 50389362
Dry mouth 15.71 9.41 280 176662 55898 50372284
Tissue infiltration 15.65 9.41 14 176928 539 50427643
Antisocial behaviour 15.64 9.41 11 176931 297 50427885
Pulmonary valve disease 15.52 9.41 5 176937 19 50428163
Product administration error 15.50 9.41 120 176822 19579 50408603
Hippocampal sclerosis 15.41 9.41 7 176935 78 50428104
Hypersomnia 15.40 9.41 99 176843 15215 50412967
Polymenorrhagia 15.39 9.41 6 176936 44 50428138
Orthostatic intolerance 15.32 9.41 18 176924 960 50427222
Hypertonic bladder 15.31 9.41 33 176909 2967 50425215
Urethral haemorrhage 15.27 9.41 6 176936 45 50428137
Respiratory tract infection 15.17 9.41 59 176883 31958 50396224
Melaena 15.10 9.41 152 176790 26712 50401470
Fluid retention 15.08 9.41 255 176687 50394 50377788
Mobility decreased 15.06 9.41 193 176749 79755 50348427
Prescribed overdose 15.06 9.41 95 176847 14505 50413677
Skin swelling 15.02 9.41 27 176915 2125 50426057
Hyporeflexia 15.02 9.41 24 176918 1716 50426466
Therapeutic response decreased 14.99 9.41 100 176842 47131 50381051
Soft tissue injury 14.97 9.41 22 176920 1462 50426720
Vertigo CNS origin 14.94 9.41 5 176937 22 50428160
Sedation complication 14.87 9.41 6 176936 8760 50419422
Borderline personality disorder 14.86 9.41 15 176927 673 50427509
Obesity 14.80 9.41 105 176837 16670 50411512
Akinesia 14.80 9.41 22 176920 1477 50426705
Therapy non-responder 14.74 9.41 111 176831 50911 50377271
Osteonecrosis of jaw 14.74 9.41 61 176881 32465 50395717
Female orgasmic disorder 14.73 9.41 6 176936 50 50428132
Pneumonia viral 14.67 9.41 3 176939 6831 50421351
Dysponesis 14.62 9.41 4 176938 7 50428175
Dysaesthesia 14.59 9.41 37 176905 3698 50424484
Blood bilirubin increased 14.57 9.41 60 176882 31978 50396204
Cytokine release syndrome 14.50 9.41 6 176936 8628 50419554
Neuroleptic malignant syndrome 14.47 9.41 77 176865 11053 50417129
Amniorrhexis 14.43 9.41 5 176937 25 50428157
Polydipsia 14.41 9.41 33 176909 3091 50425091
Respiratory alkalosis 14.37 9.41 29 176913 2490 50425692
Hallucinations, mixed 14.35 9.41 39 176903 4064 50424118
Neutrophil count decreased 14.33 9.41 98 176844 45928 50382254
Dissociative amnesia 14.27 9.41 5 176937 26 50428156
Pupil fixed 14.22 9.41 22 176920 1530 50426652
Urine abnormality 14.13 9.41 51 176891 6187 50421995
Aspiration 14.09 9.41 67 176875 9197 50418985
Uterine enlargement 14.07 9.41 18 176924 1048 50427134
Red blood cell sedimentation rate increased 14.07 9.41 54 176888 29362 50398820
Accidental exposure to product 14.04 9.41 38 176904 23019 50405163
Vertigo 14.02 9.41 257 176685 51575 50376607
Accommodation disorder 13.97 9.41 11 176931 354 50427828
Muscle tightness 13.97 9.41 72 176870 10208 50417974
Increased appetite 13.85 9.41 62 176880 8299 50419883
Reflexes abnormal 13.83 9.41 13 176929 534 50427648
Miosis 13.80 9.41 51 176891 6259 50421923
Tic 13.69 9.41 19 176923 1198 50426984
Circulatory collapse 13.67 9.41 118 176824 19882 50408300
Hepatotoxicity 13.66 9.41 49 176893 27177 50401005
Drug dose titration not performed 13.64 9.41 12 176930 452 50427730
Tardive dyskinesia 13.62 9.41 56 176886 7223 50420959
Ureteric dilatation 13.54 9.41 5 176937 31 50428151
Constipation 13.52 9.41 786 176156 184922 50243260
Ocular hyperaemia 13.48 9.41 32 176910 20260 50407922
Thrombotic microangiopathy 13.38 9.41 7 176935 8784 50419398
Feeling abnormal 13.30 9.41 551 176391 124941 50303241
Trisomy 18 13.27 9.41 5 176937 33 50428149
Balance disorder 13.27 9.41 332 176610 70258 50357924
Substance abuse 13.24 9.41 38 176904 4086 50424096
Cholecystectomy 13.23 9.41 66 176876 9237 50418945
Blood creatinine increased 13.21 9.41 187 176755 75973 50352209
Bronchopulmonary aspergillosis 13.20 9.41 5 176937 7587 50420595
Blood ethanol increased 13.18 9.41 7 176935 112 50428070
Indifference 13.18 9.41 7 176935 112 50428070
Activated partial thromboplastin time abnormal 13.12 9.41 7 176935 113 50428069
Hypercalcaemia 13.11 9.41 40 176902 23312 50404870
Delusion 12.98 9.41 72 176870 10497 50417685
Pneumonitis 12.96 9.41 56 176886 29454 50398728
Hypervigilance 12.91 9.41 10 176932 314 50427868
Throat irritation 12.91 9.41 58 176884 30181 50398001
Trismus 12.91 9.41 33 176909 3315 50424867
Visual field defect 12.88 9.41 47 176895 5732 50422450
Surgery 12.86 9.41 58 176884 30147 50398035
Sensory disturbance 12.85 9.41 78 176864 11751 50416431
Disinhibition 12.84 9.41 15 176927 795 50427387
Sleep disorder 12.80 9.41 276 176666 57007 50371175
Peritoneal perforation 12.80 9.41 7 176935 119 50428063
Atrial fibrillation 12.73 9.41 265 176677 101480 50326702
Regressive behaviour 12.67 9.41 6 176936 74 50428108
Post procedural haematuria 12.67 9.41 5 176937 38 50428144
Incoherent 12.65 9.41 38 176904 4192 50423990
Labelled drug-drug interaction medication error 12.62 9.41 71 176871 10406 50417776
Injection site bruising 12.62 9.41 76 176866 36692 50391490
Tension 12.55 9.41 29 176913 2733 50425449
Merycism 12.53 9.41 8 176934 183 50427999
Neutrophil count abnormal 12.50 9.41 27 176915 2432 50425750
Toxic epidermal necrolysis 12.48 9.41 35 176907 20957 50407225
Ejection fraction decreased 12.46 9.41 29 176913 18491 50409691
Pleurisy 12.46 9.41 5 176937 7326 50420856
Periodic limb movement disorder 12.46 9.41 8 176934 185 50427997
Fear of injection 12.45 9.41 3 176939 6100 50422082
Exposure to allergen 12.42 9.41 8 176934 186 50427996
Blood creatine phosphokinase increased 12.41 9.41 144 176798 26223 50401959
Conversion disorder 12.41 9.41 21 176921 1575 50426607
Bradycardia neonatal 12.31 9.41 15 176927 831 50427351
Paraesthesia 12.30 9.41 526 176416 119717 50308465
Pseudomonas infection 12.29 9.41 9 176933 9421 50418761
Right ventricular failure 12.28 9.41 23 176919 15870 50412312
Stress 12.28 9.41 260 176682 53533 50374649
Impaired self-care 12.26 9.41 22 176920 1729 50426453
Mental impairment 12.19 9.41 78 176864 11966 50416216
Cerebral ventricular rupture 12.05 9.41 8 176934 196 50427986
Hyponatraemic syndrome 12.01 9.41 12 176930 532 50427650
Pulmonary arterial hypertension 11.99 9.41 34 176908 20285 50407897
Anaesthesia 11.98 9.41 10 176932 350 50427832
Tachycardia 11.97 9.41 444 176498 99319 50328863
Cervix haematoma uterine 11.91 9.41 3 176939 3 50428179
Anti-neuronal antibody positive 11.91 9.41 3 176939 3 50428179
Bisexuality 11.91 9.41 3 176939 3 50428179
Onychogryphosis 11.91 9.41 3 176939 3 50428179
Electrolyte substitution therapy 11.91 9.41 3 176939 3 50428179
Neutrophil Pelger-Huet anomaly present 11.88 9.41 6 176936 86 50428096
Joint ankylosis 11.86 9.41 14 176928 750 50427432
Diarrhoea 11.85 9.41 1842 175100 586634 49841548
Somatic symptom disorder 11.83 9.41 23 176919 1921 50426261
White blood cell count decreased 11.83 9.41 314 176628 116408 50311774
Poor quality sleep 11.80 9.41 99 176843 16547 50411635
Hyperacusis 11.79 9.41 22 176920 1782 50426400
Psychiatric symptom 11.78 9.41 39 176903 4531 50423651
Initial insomnia 11.74 9.41 42 176900 5073 50423109
Apgar score low 11.62 9.41 13 176929 657 50427525
Renal disorder 11.60 9.41 53 176889 27452 50400730
Pulmonary fibrosis 11.60 9.41 45 176897 24392 50403790
Unevaluable event 11.59 9.41 104 176838 45962 50382220
Microphthalmos 11.49 9.41 7 176935 147 50428035
Bronchitis 11.41 9.41 277 176665 103882 50324300
Pyelonephritis chronic 11.41 9.41 8 176934 215 50427967
Congenital tricuspid valve incompetence 11.29 9.41 6 176936 96 50428086
Vascular encephalopathy 11.29 9.41 10 176932 380 50427802
Blunted affect 11.25 9.41 8 176934 220 50427962
Personality disorder 11.23 9.41 37 176905 4287 50423895
Menopause 11.20 9.41 25 176917 2302 50425880
Differential white blood cell count abnormal 11.17 9.41 13 176929 686 50427496
Tumour lysis syndrome 11.16 9.41 6 176936 7415 50420767
Atrophic vulvovaginitis 11.11 9.41 20 176922 1576 50426606
Dermatochalasis 11.05 9.41 3 176939 5 50428177
Crepitations 10.97 9.41 4 176938 6215 50421967
Marital problem 10.97 9.41 7 176935 160 50428022
Hepatic steatosis 10.96 9.41 132 176810 24252 50403930
Agitation neonatal 10.93 9.41 11 176931 492 50427690
Joint range of motion decreased 10.91 9.41 31 176911 18481 50409701
Sepsis 10.88 9.41 368 176574 132557 50295625
Pulmonary valve incompetence 10.84 9.41 17 176925 1196 50426986
Antipsychotic drug level above therapeutic 10.83 9.41 15 176927 944 50427238
Blood pressure decreased 10.82 9.41 264 176678 55645 50372537
Choanal atresia 10.80 9.41 4 176938 25 50428157
Carcinoid syndrome 10.77 9.41 6 176936 106 50428076
Biliary dyskinesia 10.74 9.41 26 176916 2524 50425658
Device expulsion 10.74 9.41 58 176884 28764 50399418
Congenital megacolon 10.70 9.41 3 176939 6 50428176
No adverse event 10.70 9.41 71 176871 33507 50394675
Drug reaction with eosinophilia and systemic symptoms 10.70 9.41 57 176885 28367 50399815
Loss of bladder sensation 10.67 9.41 4 176938 26 50428156
Sexually inappropriate behaviour 10.67 9.41 6 176936 108 50428074
Sunburn 10.66 9.41 25 176917 2378 50425804
Drug level above therapeutic 10.60 9.41 34 176908 3886 50424296
Phobia 10.59 9.41 9 176933 323 50427859
Mental status changes 10.57 9.41 182 176760 36090 50392092
Hypocalcaemia 10.53 9.41 53 176889 26763 50401419
Analgesic drug level above therapeutic 10.53 9.41 7 176935 172 50428010
Sebaceous gland infection 10.52 9.41 6 176936 111 50428071
Adverse event 10.49 9.41 100 176842 43663 50384519
Unintentional medical device removal 10.47 9.41 3 176939 5432 50422750
Maternal exposure during breast feeding 10.47 9.41 30 176912 3224 50424958
Loss of personal independence in daily activities 10.45 9.41 177 176765 69873 50358309
Thyroiditis 10.42 9.41 21 176921 1801 50426381
Nodal arrhythmia 10.39 9.41 16 176926 1108 50427074
Ascites 10.37 9.41 78 176864 35783 50392399
Drug level increased 10.34 9.41 108 176834 19160 50409022
Tuberculosis 10.32 9.41 12 176930 10071 50418111
Oromandibular dystonia 10.26 9.41 10 176932 430 50427752
Product administered to patient of inappropriate age 10.22 9.41 26 176916 2604 50425578
Vaginal haemorrhage 10.22 9.41 131 176811 24420 50403762
Systolic hypertension 10.22 9.41 10 176932 432 50427750
Acidosis 10.21 9.41 66 176876 10161 50418021
Aphasia 10.21 9.41 148 176794 28346 50399836
Pancreatic injury 10.18 9.41 4 176938 30 50428152
Body dysmorphic disorder 10.17 9.41 8 176934 257 50427925
Pancreatitis 10.07 9.41 207 176735 42407 50385775
Hip surgery 10.04 9.41 26 176916 2632 50425550
Agoraphobia 10.03 9.41 9 176933 348 50427834
Movement disorder 10.02 9.41 100 176842 17532 50410650
Narcolepsy 10.02 9.41 16 176926 1144 50427038
Drug abuser 10.01 9.41 27 176915 2801 50425381
Hypersexuality 9.99 9.41 10 176932 444 50427738
Psychogenic seizure 9.95 9.41 19 176923 1566 50426616
Perinatal depression 9.93 9.41 11 176931 550 50427632
Cleft lip and palate 9.90 9.41 9 176933 354 50427828
Umbilical artery vascular resistance increased 9.86 9.41 4 176938 33 50428149
Neonatal sinus tachycardia 9.86 9.41 4 176938 33 50428149
Oral neoplasm benign 9.85 9.41 3 176939 9 50428173
Tendonitis 9.82 9.41 28 176914 16677 50411505
Nystagmus 9.79 9.41 42 176900 5519 50422663
Hypertension 9.75 9.41 622 176320 210581 50217601
Respiratory tract congestion 9.74 9.41 22 176920 14177 50414005
Inner ear disorder 9.74 9.41 10 176932 458 50427724
Drug screen positive 9.65 9.41 30 176912 3372 50424810
Angiodermatitis 9.64 9.41 5 176937 76 50428106
Hyperventilation 9.64 9.41 41 176901 5368 50422814
Antisocial personality disorder 9.61 9.41 3 176939 10 50428172
Neonatal infection 9.57 9.41 6 176936 133 50428049
Vaginal discharge 9.56 9.41 40 176902 5200 50422982
Posterior reversible encephalopathy syndrome 9.55 9.41 24 176918 14904 50413278
Corneal reflex decreased 9.53 9.41 6 176936 134 50428048
Cytopenia 9.47 9.41 10 176932 8765 50419417
Myocardial fibrosis 9.47 9.41 12 176930 692 50427490
Repetitive speech 9.47 9.41 8 176934 285 50427897

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 959.82 10.64 1237 83816 89009 29400465
Toxicity to various agents 806.30 10.64 1631 83422 172030 29317444
Serotonin syndrome 492.47 10.64 406 84647 17106 29472368
Drug abuse 474.47 10.64 835 84218 79048 29410426
Suicidal ideation 335.70 10.64 455 84598 34261 29455213
Intentional overdose 290.75 10.64 449 84604 38079 29451395
Overdose 273.01 10.64 665 84388 79154 29410320
Suicide attempt 227.76 10.64 376 84677 33734 29455740
Foetal exposure during pregnancy 198.04 10.64 352 84701 33515 29455959
Drug interaction 187.78 10.64 1086 83967 196299 29293175
Electrocardiogram QT prolonged 160.17 10.64 334 84719 35803 29453671
Anxiety 158.80 10.64 573 84480 84792 29404682
Disinhibition 146.20 10.64 92 84961 2515 29486959
Intentional self-injury 144.86 10.64 179 84874 12282 29477192
Respiratory disorder neonatal 141.36 10.64 73 84980 1352 29488122
Obsessive-compulsive disorder 141.05 10.64 112 84941 4464 29485010
Poisoning 128.34 10.64 151 84902 9842 29479632
Antipsychotic drug level below therapeutic 126.87 10.64 76 84977 1898 29487576
Paranoia 126.44 10.64 149 84904 9728 29479746
Off label use 118.72 10.64 455 84598 300345 29189129
Aggression 117.99 10.64 293 84760 35248 29454226
Febrile neutropenia 113.13 10.64 94 84959 112146 29377328
Pyrexia 112.88 10.64 436 84617 287186 29202288
Psychotic disorder 111.86 10.64 206 84847 20148 29469326
Agitation 108.92 10.64 360 84693 50944 29438530
Drug withdrawal syndrome neonatal 108.74 10.64 85 84968 3310 29486164
Agitation neonatal 107.36 10.64 55 84998 1001 29488473
Restlessness 106.77 10.64 212 84841 21933 29467541
Irritability 106.72 10.64 212 84841 21940 29467534
Respiratory arrest 105.49 10.64 231 84822 25602 29463872
Therapeutic product effect variable 104.66 10.64 66 84987 1811 29487663
Neonatal respiratory distress syndrome 98.08 10.64 84 84969 3726 29485748
Depression 97.93 10.64 494 84559 84653 29404821
Akathisia 95.20 10.64 107 84946 6635 29482839
Loss of libido 94.87 10.64 67 84986 2229 29487245
Confusional state 90.16 10.64 653 84400 127224 29362250
Tearfulness 89.90 10.64 57 84996 1579 29487895
Hypertonia neonatal 89.12 10.64 36 85017 364 29489110
Small for dates baby 88.27 10.64 77 84976 3502 29485972
Depressed mood 87.28 10.64 164 84889 16284 29473190
Disturbance in attention 86.81 10.64 191 84862 21233 29468241
Increased appetite 85.22 10.64 96 84957 5968 29483506
Euphoric mood 84.79 10.64 86 84967 4739 29484735
Atrial septal defect 82.91 10.64 100 84953 6689 29482785
Pneumonia 78.63 10.64 569 84484 319603 29169871
Tremor 78.53 10.64 418 84635 73120 29416354
Intrusive thoughts 78.38 10.64 29 85024 226 29489248
Depression suicidal 75.23 10.64 47 85006 1268 29488206
Erectile dysfunction 73.46 10.64 161 84892 17848 29471626
Sexual dysfunction 73.24 10.64 87 84966 5727 29483747
Asphyxia 67.72 10.64 80 84973 5235 29484239
Temperature regulation disorder 63.89 10.64 32 85021 554 29488920
Depressive symptom 63.85 10.64 47 85006 1670 29487804
Homicidal ideation 63.65 10.64 55 84998 2469 29487005
Cardio-respiratory arrest 62.70 10.64 300 84753 50301 29439173
Acute kidney injury 62.37 10.64 477 84576 264790 29224684
Interstitial lung disease 61.04 10.64 46 85007 57672 29431802
Anger 60.81 10.64 111 84942 10779 29478695
Psychiatric decompensation 60.09 10.64 43 85010 1461 29488013
Maternal drugs affecting foetus 58.79 10.64 64 84989 3829 29485645
Malignant neoplasm progression 58.41 10.64 76 84977 73783 29415691
Hepatic function abnormal 58.34 10.64 20 85033 39239 29450235
Neonatal seizure 57.44 10.64 28 85025 456 29489018
Accidental death 57.19 10.64 48 85005 2070 29487404
Intentional product misuse 57.14 10.64 224 84829 34437 29455037
Diarrhoea 54.89 10.64 653 84400 332045 29157429
Cryptorchism 54.49 10.64 45 85008 1897 29487577
Sepsis 54.04 10.64 219 84834 142463 29347011
Libido decreased 53.62 10.64 64 84989 4234 29485240
Somnambulism 53.09 10.64 52 85001 2746 29486728
Sopor 53.08 10.64 105 84948 10829 29478645
Septic shock 53.02 10.64 61 84992 62499 29426975
Hallucination, auditory 52.58 10.64 97 84956 9496 29479978
Fall 51.37 10.64 754 84299 176424 29313050
Sedation 51.04 10.64 137 84916 17268 29472206
Somnolence 50.96 10.64 452 84601 93503 29395971
Muscle twitching 50.22 10.64 86 84967 7940 29481534
Homicide 50.17 10.64 32 85021 896 29488578
Exposure during pregnancy 50.07 10.64 89 84964 8465 29481009
Hallucination 48.96 10.64 256 84797 44456 29445018
Muscle rigidity 48.89 10.64 93 84960 9318 29480156
Cytomegalovirus infection 48.83 10.64 5 85048 23210 29466264
Mydriasis 48.78 10.64 73 84980 6012 29483462
Hypospadias 48.23 10.64 51 85002 2951 29486523
Orgasmic sensation decreased 48.19 10.64 14 85039 44 29489430
Platelet count decreased 48.09 10.64 148 84905 104524 29384950
Tachyphrenia 48.04 10.64 34 85019 1135 29488339
Prescription drug used without a prescription 46.93 10.64 35 85018 1269 29488205
Panic attack 46.65 10.64 85 84968 8241 29481233
Mental impairment 45.85 10.64 89 84964 9052 29480422
Coma scale abnormal 45.50 10.64 53 85000 3416 29486058
Poverty of speech 45.30 10.64 19 85034 213 29489261
Neonatal hypoxia 44.98 10.64 22 85031 361 29489113
Bradycardia neonatal 44.91 10.64 30 85023 910 29488564
Multiple organ dysfunction syndrome 44.89 10.64 70 84983 63046 29426428
Drug screen positive 44.81 10.64 55 84998 3746 29485728
Obesity 44.64 10.64 92 84961 9771 29479703
Derealisation 44.39 10.64 25 85028 554 29488920
Logorrhoea 44.31 10.64 43 85010 2245 29487229
Psychomotor skills impaired 44.17 10.64 46 85007 2615 29486859
Cardiac arrest 43.97 10.64 407 84646 85184 29404290
Cardiac failure 42.47 10.64 104 84949 79183 29410291
Renal failure 42.44 10.64 186 84867 118413 29371061
Mood swings 41.87 10.64 75 84978 7176 29482298
Hanging 41.21 10.64 15 85038 111 29489363
Hallucination, visual 40.86 10.64 115 84938 14900 29474574
Anorgasmia 40.65 10.64 24 85029 583 29488891
Hypomania 40.48 10.64 40 85013 2135 29487339
Haemangioma congenital 39.49 10.64 22 85031 477 29488997
Hyperreflexia 39.14 10.64 44 85009 2728 29486746
Product use in unapproved indication 39.07 10.64 124 84929 86751 29402723
Withdrawal syndrome 38.99 10.64 93 84960 10899 29478575
Hyperhidrosis 38.93 10.64 318 84735 64222 29425252
Neutropenia 38.86 10.64 221 84832 131490 29357984
Drug reaction with eosinophilia and systemic symptoms 38.68 10.64 16 85037 27976 29461498
Drug ineffective 38.63 10.64 775 84278 362395 29127079
Hypoglycaemia neonatal 38.37 10.64 35 85018 1689 29487785
Vasoplegia syndrome 38.31 10.64 33 85020 1475 29487999
Prescribed overdose 38.13 10.64 80 84973 8603 29480871
Depressed level of consciousness 38.04 10.64 208 84845 36734 29452740
Congenital ureteropelvic junction obstruction 37.26 10.64 12 85041 58 29489416
Amnesia 37.04 10.64 146 84907 22497 29466977
Genital hypoaesthesia 36.89 10.64 16 85037 196 29489278
Alcohol use 36.40 10.64 45 85008 3087 29486387
Drug withdrawal syndrome 36.18 10.64 124 84929 17860 29471614
Drug resistance 35.60 10.64 9 85044 21531 29467943
Stomatitis 35.03 10.64 33 85020 37080 29452394
Anaemia 34.74 10.64 390 84663 200561 29288913
Atrial fibrillation 34.64 10.64 171 84882 105475 29383999
Congenital hepatomegaly 34.54 10.64 9 85044 16 29489458
Disease progression 34.04 10.64 121 84932 81795 29407679
Inappropriate antidiuretic hormone secretion 34.04 10.64 88 84965 10844 29478630
Electrocardiogram QRS complex prolonged 33.94 10.64 50 85003 4060 29485414
Premature ejaculation 33.90 10.64 13 85040 113 29489361
Mucosal inflammation 33.63 10.64 25 85028 31570 29457904
Parathyroid gland enlargement 33.51 10.64 13 85040 117 29489357
Pleural effusion 33.49 10.64 101 84952 71807 29417667
Rhinitis perennial 33.25 10.64 15 85038 203 29489271
Renal impairment 33.23 10.64 121 84932 81212 29408262
Bipolar disorder 33.04 10.64 44 85009 3251 29486223
Mania 32.58 10.64 75 84978 8588 29480886
Respiratory failure 32.55 10.64 156 84897 96975 29392499
Dyskinesia 32.53 10.64 129 84924 19932 29469542
Infantile apnoea 32.40 10.64 24 85029 861 29488613
Upper respiratory fungal infection 32.40 10.64 13 85040 129 29489345
Negative thoughts 32.36 10.64 21 85032 606 29488868
Newborn persistent pulmonary hypertension 31.74 10.64 12 85041 100 29489374
Hyperventilation 30.83 10.64 36 85017 2326 29487148
Apgar score low 30.79 10.64 23 85030 836 29488638
Dyslipidaemia 30.38 10.64 59 84994 6002 29483472
Gun shot wound 30.15 10.64 25 85028 1060 29488414
Neuropathy peripheral 30.12 10.64 104 84949 70923 29418551
Rheumatoid arthritis 29.86 10.64 29 85024 32123 29457351
Oedema peripheral 29.86 10.64 175 84878 103382 29386092
Psychomotor hyperactivity 29.68 10.64 70 84983 8143 29481331
Circulatory collapse 29.41 10.64 119 84934 18554 29470920
Loss of consciousness 29.35 10.64 334 84719 73722 29415752
Optic nerve hypoplasia 29.13 10.64 6 85047 0 29489474
Forced expiratory volume 28.85 10.64 11 85042 94 29489380
Nightmare 28.70 10.64 85 84968 11332 29478142
Patent ductus arteriosus 28.66 10.64 40 85013 3091 29486383
Tardive dyskinesia 28.60 10.64 53 85000 5205 29484269
Thrombocytopenia 28.57 10.64 249 84804 134574 29354900
Apathy 28.44 10.64 58 84995 6113 29483361
Congenital pulmonary hypertension 28.03 10.64 9 85044 43 29489431
Toxicologic test abnormal 27.87 10.64 18 85035 515 29488959
Mental disorder 27.75 10.64 91 84962 12814 29476660
Failure to suspend medication 27.57 10.64 16 85037 376 29489098
Spontaneous penile erection 27.51 10.64 13 85040 197 29489277
Pancytopenia 27.03 10.64 135 84918 83033 29406441
Hyperbilirubinaemia neonatal 26.89 10.64 20 85033 722 29488752
Decreased appetite 26.73 10.64 278 84775 145064 29344410
Torsade de pointes 26.54 10.64 59 84994 6602 29482872
Disturbance in sexual arousal 26.49 10.64 11 85042 120 29489354
Infection 26.45 10.64 122 84931 76629 29412845
Foot deformity 26.42 10.64 44 85009 3971 29485503
Pneumonitis 26.39 10.64 25 85028 28019 29461455
Limb deformity 26.12 10.64 17 85036 493 29488981
Impulsive behaviour 26.01 10.64 30 85023 1913 29487561
Clonus 25.78 10.64 33 85020 2345 29487129
Tremor neonatal 25.75 10.64 15 85038 355 29489119
Sexual relationship change 25.70 10.64 7 85046 16 29489458
Hospitalisation 25.66 10.64 59 84994 45929 29443545
Disseminated intravascular coagulation 25.15 10.64 13 85040 19967 29469507
Radiologically isolated syndrome 24.98 10.64 6 85047 6 29489468
Cytokine release syndrome 24.76 10.64 4 85049 13115 29476359
COVID-19 24.60 10.64 41 85012 35973 29453501
Selective eating disorder 24.52 10.64 27 85026 1636 29487838
Disorientation 24.47 10.64 157 84896 29358 29460116
Myoclonus 24.39 10.64 89 84964 13220 29476254
Congenital hypercoagulation 24.27 10.64 5 85048 0 29489474
Unresponsive to stimuli 24.22 10.64 139 84914 24987 29464487
Pneumocystis jirovecii pneumonia 24.15 10.64 9 85044 16770 29472704
Panic reaction 24.13 10.64 24 85029 1291 29488183
Seizure 24.11 10.64 389 84664 92734 29396740
Peripheral swelling 23.98 10.64 98 84955 63641 29425833
Conduction disorder 23.95 10.64 28 85025 1812 29487662
Hypertonia 23.92 10.64 41 85012 3788 29485686
Hand deformity 23.79 10.64 30 85023 2100 29487374
C-reactive protein increased 23.73 10.64 58 84995 44205 29445269
Antipsychotic drug level increased 23.32 10.64 37 85016 3206 29486268
Heat stroke 23.31 10.64 20 85033 889 29488585
Dyspnoea 23.13 10.64 740 84313 325992 29163482
Parkinsonism 23.08 10.64 59 84994 7219 29482255
Congenital central nervous system anomaly 22.90 10.64 15 85038 440 29489034
Neonatal pneumonia 22.88 10.64 10 85043 125 29489349
Drug hypersensitivity 22.83 10.64 110 84943 68296 29421178
Kinematic imbalances due to suboccipital strain 22.57 10.64 6 85047 12 29489462
Oedema 22.54 10.64 52 85001 40431 29449043
Weight increased 22.43 10.64 327 84726 76340 29413134
Tic 22.36 10.64 27 85026 1808 29487666
Myocardial infarction 22.35 10.64 206 84847 110090 29379384
Bladder trabeculation 21.93 10.64 5 85048 3 29489471
Brain oedema 21.79 10.64 81 84972 12139 29477335
Eosinophilia 21.75 10.64 19 85034 22142 29467332
Dreamy state 21.65 10.64 6 85047 15 29489459
Leukaemia 21.48 10.64 39 85014 3771 29485703
Major depression 21.29 10.64 39 85014 3796 29485678
Neonatal disorder 21.27 10.64 18 85035 785 29488689
Congenital hydronephrosis 21.22 10.64 17 85036 686 29488788
Bronchopulmonary aspergillosis 20.71 10.64 5 85048 12339 29477135
Blood alcohol increased 20.66 10.64 17 85036 713 29488761
Myocardial fibrosis 20.55 10.64 20 85033 1048 29488426
Postmortem blood drug level increased 20.54 10.64 11 85042 220 29489254
Thrombosis 20.36 10.64 60 84993 42985 29446489
Impaired work ability 20.30 10.64 48 85005 5592 29483882
Interstitial granulomatous dermatitis 20.29 10.64 10 85043 167 29489307
Haemophagocytic lymphohistiocytosis 20.28 10.64 3 85050 10501 29478973
Gender dysphoria 20.21 10.64 7 85046 44 29489430
Oesophageal perforation 20.16 10.64 17 85036 738 29488736
Lactic acidosis 20.14 10.64 35 85018 30212 29459262
Psychomotor retardation 20.10 10.64 33 85020 2943 29486531
Agoraphobia 20.06 10.64 11 85042 231 29489243
Maternal exposure during breast feeding 19.99 10.64 23 85030 1463 29488011
Pilonidal cyst congenital 19.95 10.64 6 85047 22 29489452
Bone marrow failure 19.93 10.64 30 85023 27419 29462055
Cough 19.92 10.64 251 84802 126476 29362998
Nasopharyngitis 19.87 10.64 96 84957 59569 29429905
Pulmonary oedema 19.84 10.64 199 84854 42536 29446938
Victim of chemical submission 19.81 10.64 7 85046 47 29489427
Epistaxis 19.76 10.64 79 84974 51625 29437849
Adjustment disorder 19.74 10.64 19 85034 982 29488492
Ventricular septal defect 19.73 10.64 36 85017 3493 29485981
Tachycardia 19.69 10.64 305 84748 72105 29417369
Drug-induced liver injury 19.57 10.64 20 85033 21635 29467839
Infusion related reaction 19.46 10.64 63 84990 43823 29445651
Mental status changes 19.40 10.64 169 84884 34758 29454716
Hyponatraemic syndrome 19.37 10.64 10 85043 185 29489289
Rash 19.22 10.64 408 84645 189411 29300063
Haematuria 19.13 10.64 64 84989 44075 29445399
Decreased interest 19.10 10.64 27 85026 2111 29487363
Synovitis 19.09 10.64 4 85049 10886 29478588
Tumour lysis syndrome 19.07 10.64 8 85045 13876 29475598
Persistent foetal circulation 18.97 10.64 12 85041 331 29489143
Delusion 18.89 10.64 73 84980 11143 29478331
Hyponatraemia 18.82 10.64 286 84767 67347 29422127
Dysphemia 18.76 10.64 22 85031 1428 29488046
Osmolar gap abnormal 18.63 10.64 6 85047 29 29489445
Choanal atresia 18.49 10.64 5 85048 11 29489463
Substance abuse 18.48 10.64 52 85001 6735 29482739
Anhidrosis 18.44 10.64 8 85045 98 29489376
Hyperbilirubinaemia 18.38 10.64 10 85043 14924 29474550
Constipation 18.36 10.64 225 84828 113935 29375539
Schizoaffective disorder 18.34 10.64 19 85034 1073 29488401
Feeling abnormal 18.27 10.64 238 84815 54207 29435267
Drug dependence 18.25 10.64 113 84940 20868 29468606
Parkinson's disease 18.20 10.64 21 85032 1340 29488134
Intestinal congestion 18.19 10.64 5 85048 12 29489462
Suicidal behaviour 18.14 10.64 21 85032 1344 29488130
Periventricular leukomalacia 18.14 10.64 6 85047 32 29489442
Duodenal ulcer perforation 18.09 10.64 22 85031 1484 29487990
Hypotonia neonatal 18.07 10.64 20 85033 1219 29488255
Diffuse large B-cell lymphoma stage II 17.99 10.64 6 85047 33 29489441
Hypertrophic cardiomyopathy 17.93 10.64 17 85036 862 29488612
Hepatitis C virus test positive 17.90 10.64 11 85042 288 29489186
Joint swelling 17.62 10.64 78 84975 49552 29439922
Finnegan score increased 17.38 10.64 5 85048 15 29489459
Exposure via ingestion 17.32 10.64 25 85028 1993 29487481
Toxic epidermal necrolysis 17.29 10.64 16 85037 18137 29471337
Acute myocardial infarction 17.28 10.64 76 84977 48362 29441112
Libido disorder 17.08 10.64 10 85043 239 29489235
Facial spasm 17.03 10.64 9 85044 175 29489299
Blood bilirubin increased 16.95 10.64 46 85007 33847 29455627
Neonatal infection 16.94 10.64 12 85041 401 29489073
Myelosuppression 16.87 10.64 7 85046 12220 29477254
Jaundice 16.82 10.64 37 85016 29259 29460215
Slow response to stimuli 16.67 10.64 15 85038 711 29488763
Bronchopulmonary aspergillosis allergic 16.65 10.64 13 85040 505 29488969
Pregnancy 16.65 10.64 10 85043 251 29489223
Myelodysplastic syndrome 16.58 10.64 16 85037 17778 29471696
Opiates positive 16.57 10.64 13 85040 509 29488965
Urinary retention 16.51 10.64 152 84901 31746 29457728
Hypercalcaemia 16.51 10.64 8 85045 12751 29476723
Acute myeloid leukaemia 16.40 10.64 14 85039 16499 29472975
Osteonecrosis of jaw 16.39 10.64 14 85039 16496 29472978
Wrong patient received product 16.36 10.64 26 85027 2256 29487218
Intentional product use issue 16.20 10.64 65 84988 42433 29447041
Incontinence 16.17 10.64 41 85012 4991 29484483
Economic problem 16.11 10.64 19 85034 1241 29488233
Coordination abnormal 16.05 10.64 51 85002 7063 29482411
Arachnoid cyst 16.04 10.64 9 85044 198 29489276
Generalised tonic-clonic seizure 15.98 10.64 102 84951 19037 29470437
Alcoholism 15.98 10.64 28 85025 2633 29486841
Cyanosis neonatal 15.97 10.64 10 85043 271 29489203
Acute stress disorder 15.95 10.64 8 85045 139 29489335
Blood creatinine increased 15.94 10.64 162 84891 84940 29404534
Poor feeding infant 15.93 10.64 12 85041 442 29489032
Rectourethral fistula 15.90 10.64 5 85048 22 29489452
Accidental poisoning 15.80 10.64 13 85040 545 29488929
Spermatozoa morphology abnormal 15.77 10.64 4 85049 6 29489468
Blood catecholamines decreased 15.77 10.64 4 85049 6 29489468
Xanthoma 15.77 10.64 7 85046 91 29489383
Infant irritability 15.72 10.64 5 85048 23 29489451
Poor quality sleep 15.54 10.64 51 85002 7182 29482292
Congenital pneumonia 15.50 10.64 7 85046 95 29489379
Urticaria 15.41 10.64 93 84960 54567 29434907
Influenza 15.37 10.64 65 84988 41816 29447658
Caesarean section 15.31 10.64 23 85030 1900 29487574
Colitis 15.18 10.64 43 85010 31205 29458269
Morbid thoughts 15.16 10.64 9 85044 221 29489253
Liver disorder 15.16 10.64 36 85017 27713 29461761
Cardiac failure congestive 15.09 10.64 144 84909 76437 29413037
Abnormal behaviour 15.05 10.64 116 84937 23011 29466463
Positive end-expiratory pressure 15.05 10.64 4 85049 8 29489466
Hydrocele 15.04 10.64 23 85030 1930 29487544
Scleroderma renal crisis 14.99 10.64 7 85046 103 29489371
Physical assault 14.95 10.64 17 85036 1067 29488407
Eye haematoma 14.91 10.64 6 85047 60 29489414
Anomaly of external ear congenital 14.87 10.64 7 85046 105 29489369
Infantile vomiting 14.77 10.64 5 85048 29 29489445
Cleft lip and palate 14.69 10.64 10 85043 313 29489161
Resting tremor 14.66 10.64 13 85040 604 29488870
Lymphoma 14.61 10.64 5 85048 9823 29479651
Holoprosencephaly 14.56 10.64 3 85050 0 29489474
Visual snow syndrome 14.56 10.64 3 85050 0 29489474
Gas poisoning 14.56 10.64 3 85050 0 29489474
Epilepsy congenital 14.56 10.64 3 85050 0 29489474
Gastrointestinal mucosal exfoliation 14.53 10.64 7 85046 111 29489363
Granulocytopenia 14.47 10.64 44 85009 5950 29483524
Self-injurious ideation 14.47 10.64 20 85033 1531 29487943
Genital anaesthesia 14.44 10.64 4 85049 10 29489464
Hypertrophic scar 14.44 10.64 4 85049 10 29489464
Haemoglobin decreased 14.40 10.64 222 84831 108153 29381321
Accidental overdose 14.22 10.64 93 84960 17500 29471974
Memory impairment 14.22 10.64 164 84889 36306 29453168
JC virus CSF test positive 14.14 10.64 7 85046 118 29489356
Hepatic failure 14.13 10.64 45 85008 31467 29458007
Bacterial infection 14.09 10.64 10 85043 12938 29476536
Radicular pain 14.09 10.64 6 85047 70 29489404
Salivary hypersecretion 13.96 10.64 50 85003 7359 29482115
White blood cell count decreased 13.89 10.64 163 84890 83199 29406275
Thrombotic stroke 13.86 10.64 9 85044 260 29489214
Pleurothotonus 13.85 10.64 16 85037 1022 29488452
Priapism 13.84 10.64 36 85017 4452 29485022
Pulmonary embolism 13.80 10.64 147 84906 76387 29413087
Opisthotonus 13.75 10.64 11 85042 443 29489031
Erythema 13.72 10.64 145 84908 75461 29414013
Vestibular disorder 13.65 10.64 16 85037 1038 29488436
Psychiatric symptom 13.59 10.64 29 85024 3155 29486319
Ventricular flutter 13.59 10.64 6 85047 77 29489397
Iron binding capacity total increased 13.51 10.64 5 85048 39 29489435
Head circumference abnormal 13.51 10.64 5 85048 39 29489435
Renal disorder 13.42 10.64 28 85025 22567 29466907
Arthropathy 13.41 10.64 26 85027 21528 29467946
Rhinorrhoea 13.35 10.64 26 85027 21493 29467981
Abnormal dreams 13.30 10.64 47 85006 6873 29482601
Brugada syndrome 13.25 10.64 13 85040 688 29488786
Angle closure glaucoma 13.22 10.64 14 85039 811 29488663
Liver function test increased 13.17 10.64 9 85044 11876 29477598
Dyspnoea exertional 13.17 10.64 57 84996 36433 29453041
Insomnia 13.06 10.64 341 84712 88420 29401054
Cytopenia 13.04 10.64 6 85047 9853 29479621
Congenital hydrocephalus 12.81 10.64 6 85047 89 29489385
Dissociation 12.77 10.64 16 85037 1113 29488361
Blood urea increased 12.71 10.64 40 85013 28072 29461402
Micropenis 12.70 10.64 5 85048 47 29489427
Cognitive disorder 12.68 10.64 113 84940 23386 29466088
Teratogenicity 12.61 10.64 5 85048 48 29489426
Activation syndrome 12.57 10.64 6 85047 93 29489381
Testicular atrophy 12.50 10.64 11 85042 506 29488968
Muscle mass 12.48 10.64 8 85045 226 29489248
Crystalluria 12.45 10.64 10 85043 405 29489069
Bronchial disorder 12.41 10.64 16 85037 1145 29488329
Blood pressure fluctuation 12.37 10.64 24 85029 19870 29469604
Staphylococcal sepsis 12.35 10.64 5 85048 8857 29480617
Adjusted calcium increased 12.31 10.64 4 85049 20 29489454
Respiratory distress 12.30 10.64 49 85004 32057 29457417
Tendon disorder 12.27 10.64 24 85029 2454 29487020
Carbon monoxide poisoning 12.24 10.64 6 85047 99 29489375
Thinking abnormal 12.24 10.64 38 85015 5198 29484276
Schizophrenia 12.11 10.64 44 85009 6521 29482953
Personality change 12.11 10.64 35 85018 4603 29484871
Male orgasmic disorder 12.08 10.64 6 85047 102 29489372
Haematospermia 12.03 10.64 9 85044 328 29489146
Leukopenia 11.90 10.64 224 84829 54979 29434495
Pneumonia bacterial 11.88 10.64 6 85047 9337 29480137
Coagulation factor increased 11.85 10.64 5 85048 57 29489417
Product use issue 11.79 10.64 93 84960 51351 29438123
Aspergillus infection 11.75 10.64 8 85045 10573 29478901
Semen volume decreased 11.66 10.64 9 85044 344 29489130
Social avoidant behaviour 11.65 10.64 26 85027 2916 29486558
Pruritus 11.56 10.64 252 84801 116597 29372877
Antipsychotic drug level above therapeutic 11.50 10.64 15 85038 1086 29488388
Dystonia 11.49 10.64 57 84996 9692 29479782
Pulmonary valve stenosis 11.48 10.64 9 85044 352 29489122
Mood altered 11.45 10.64 50 85003 8061 29481413
Kidney transplant rejection 11.43 10.64 3 85050 7002 29482472
Angioedema 11.42 10.64 50 85003 31865 29457609
Lacrimation increased 11.37 10.64 3 85050 6977 29482497
Toxic skin eruption 11.34 10.64 7 85046 9750 29479724
Long QT syndrome 11.34 10.64 22 85031 2236 29487238
Genital pain 11.33 10.64 7 85046 185 29489289
Tension 11.32 10.64 20 85033 1893 29487581
Oesophageal atresia 11.31 10.64 10 85043 463 29489011
Alcoholic psychosis 11.28 10.64 3 85050 6 29489468
Personality disorder 11.27 10.64 15 85038 1108 29488366
Coagulation factor VII level decreased 11.25 10.64 6 85047 119 29489355
Application site hypersensitivity 11.25 10.64 6 85047 119 29489355
Venoocclusive liver disease 11.22 10.64 3 85050 6914 29482560
Musculoskeletal pain 11.21 10.64 44 85009 28909 29460565
CSF test abnormal 11.20 10.64 7 85046 189 29489285
Hyperuricaemia 11.15 10.64 3 85050 6886 29482588
Myositis 11.12 10.64 8 85045 10275 29479199
Drug abuser 11.09 10.64 30 85023 3797 29485677
Pulmonary artery stenosis congenital 11.08 10.64 10 85043 476 29488998
Renal vasculitis 11.07 10.64 6 85047 123 29489351
Infertility 11.07 10.64 7 85046 193 29489281
Graft versus host disease 11.07 10.64 7 85046 9621 29479853
CSF white blood cell count positive 11.06 10.64 4 85049 29 29489445
Yawning 11.01 10.64 10 85043 480 29488994
Bradykinesia 10.99 10.64 28 85025 3419 29486055
Hepatic enzyme increased 10.89 10.64 55 84998 33744 29455730
Osteoporosis 10.85 10.64 9 85044 10760 29478714
Palmar-plantar erythrodysaesthesia syndrome 10.84 10.64 16 85037 14743 29474731
Self-medication 10.83 10.64 21 85032 2133 29487341
Alcohol interaction 10.83 10.64 24 85029 2679 29486795
Alcohol poisoning 10.81 10.64 26 85027 3063 29486411
Emotional disorder 10.80 10.64 35 85018 4896 29484578
Incoherent 10.80 10.64 31 85022 4061 29485413
Bronchitis 10.77 10.64 62 84991 36806 29452668
Bacteraemia 10.76 10.64 19 85034 16304 29473170
Dysarthria 10.73 10.64 136 84917 30775 29458699
HIV peripheral neuropathy 10.72 10.64 4 85049 32 29489442
Seizure like phenomena 10.71 10.64 11 85042 615 29488859
Alcohol abuse 10.64 10.64 32 85021 4301 29485173

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2004.19 9.84 3046 210765 221368 64063553
Toxicity to various agents 1786.37 9.84 3801 210010 359712 63925209
Drug abuse 1338.66 9.84 1907 211904 130467 64154454
Serotonin syndrome 973.41 9.84 901 212910 38381 64246540
Overdose 641.35 9.84 1544 212267 158022 64126899
Electrocardiogram QT prolonged 636.69 9.84 1028 212783 78420 64206501
Intentional overdose 609.64 9.84 1080 212731 88864 64196057
Drug interaction 536.37 9.84 2497 211314 359586 63925335
Suicidal ideation 496.65 9.84 834 212977 65708 64219213
Suicide attempt 435.86 9.84 817 212994 70190 64214731
Respiratory arrest 323.05 9.84 608 213203 52377 64232544
Sopor 320.94 9.84 442 213369 29219 64255702
Poisoning 317.14 9.84 377 213434 21502 64263419
Intentional self-injury 310.05 9.84 430 213381 28614 64256307
Agitation 296.26 9.84 799 213012 87568 64197353
Anxiety 279.24 9.84 1370 212441 201279 64083642
Synovitis 258.43 9.84 18 213793 99072 64185849
Cardio-respiratory arrest 248.06 9.84 804 213007 97589 64187332
Off label use 247.83 9.84 1168 212643 631638 63653283
Drug ineffective 247.79 9.84 1702 212109 838545 63446376
Torsade de pointes 222.22 9.84 281 213530 17082 64267839
Febrile neutropenia 207.17 9.84 190 213621 187467 64097454
Tremor 206.82 9.84 1006 212805 147224 64137697
Hyponatraemia 197.19 9.84 993 212818 147346 64137575
Temperature regulation disorder 185.33 9.84 135 213676 4076 64280845
Hyperhidrosis 167.23 9.84 838 212973 124082 64160839
Pyrexia 165.41 9.84 1129 212682 557515 63727406
Systemic lupus erythematosus 162.93 9.84 30 213781 77582 64207339
Restlessness 162.72 9.84 388 213423 39397 64245524
Hand deformity 161.94 9.84 12 213799 62759 64222162
Cardiac arrest 159.61 9.84 964 212847 153100 64131821
Treatment failure 158.95 9.84 95 213716 116721 64168200
Aggression 155.83 9.84 419 213392 45813 64239108
Panic attack 154.05 9.84 261 213550 20692 64264229
Confusional state 148.16 9.84 1418 212393 259726 64025195
Disturbance in attention 147.34 9.84 381 213430 40693 64244228
Depression 136.86 9.84 1058 212753 182233 64102688
Drug intolerance 136.21 9.84 260 213551 187732 64097189
Mydriasis 136.19 9.84 208 213603 15104 64269817
Loss of libido 136.17 9.84 90 213721 2314 64282607
Pemphigus 135.13 9.84 20 213791 60681 64224240
Food allergy 133.57 9.84 147 213664 7704 64277217
Electrocardiogram QRS complex prolonged 133.47 9.84 159 213652 9085 64275836
Infusion related reaction 132.27 9.84 213 213598 164254 64120667
Somnolence 131.85 9.84 1138 212673 202507 64082414
Irritability 130.92 9.84 340 213471 36406 64248515
Psychotic disorder 130.52 9.84 327 213484 34251 64250670
Coeliac disease 129.96 9.84 141 213670 7271 64277650
Pericarditis 129.44 9.84 25 213786 62491 64222430
Fall 127.88 9.84 2015 211796 414811 63870110
Withdrawal syndrome 126.61 9.84 256 213555 23236 64261685
Anorgasmia 123.01 9.84 61 213750 888 64284033
Pneumonia 121.79 9.84 1227 212584 558349 63726572
Interstitial lung disease 121.42 9.84 88 213723 97644 64187277
Paranoia 117.98 9.84 202 213609 16150 64268771
Arthropathy 115.96 9.84 138 213673 120829 64164092
Muscle twitching 115.73 9.84 218 213593 18780 64266141
Malignant neoplasm progression 110.08 9.84 127 213684 112744 64172177
Intentional product misuse 107.52 9.84 500 213311 71795 64213126
Joint swelling 107.08 9.84 361 213450 215021 64069900
Accidental overdose 105.99 9.84 297 213514 33260 64251661
Depressed mood 105.88 9.84 338 213473 40674 64244247
Nightmare 105.18 9.84 222 213589 20771 64264150
Therapeutic product effect decreased 104.90 9.84 137 213674 115214 64169707
Muscle rigidity 104.58 9.84 199 213612 17274 64267647
Akathisia 103.28 9.84 157 213654 11353 64273568
Seizure 101.96 9.84 921 212890 165971 64118950
Rash 100.69 9.84 1003 212808 457546 63827375
Myoclonus 100.59 9.84 243 213568 24875 64260046
Septic shock 99.23 9.84 122 213689 105315 64179606
Infection 98.79 9.84 300 213511 184580 64100341
Product use in unapproved indication 98.42 9.84 281 213530 176337 64108584
Neutropenia 98.31 9.84 434 213377 239190 64045731
Helicobacter infection 97.07 9.84 8 213803 38354 64246567
Coma scale abnormal 96.60 9.84 124 213687 7650 64277271
Loss of consciousness 96.44 9.84 830 212981 147535 64137386
Unresponsive to stimuli 96.20 9.84 376 213435 50017 64234904
Rheumatoid factor positive 95.13 9.84 5 213806 34933 64249988
Alopecia 94.26 9.84 261 213550 165429 64119492
Hepatic function abnormal 93.69 9.84 48 213763 64265 64220656
Drug withdrawal syndrome 93.05 9.84 271 213540 31020 64253901
Acute kidney injury 87.57 9.84 1010 212801 448230 63836691
Bruxism 87.52 9.84 82 213729 3542 64281379
Accidental death 87.50 9.84 83 213728 3642 64281279
Hyperreflexia 87.23 9.84 113 213698 7035 64277886
Obsessive-compulsive disorder 86.83 9.84 93 213718 4725 64280196
Cytomegalovirus infection 83.38 9.84 12 213799 37187 64247734
Mania 82.49 9.84 173 213638 16113 64268808
Hallucination 81.47 9.84 465 213346 72323 64212598
Peripheral swelling 79.16 9.84 390 213421 208763 64076158
Libido decreased 78.67 9.84 88 213723 4696 64280225
Exposure via ingestion 78.61 9.84 89 213722 4813 64280108
Pancytopenia 77.65 9.84 231 213580 143078 64141843
Thrombocytopenia 77.05 9.84 431 213380 223370 64061551
Depression suicidal 75.68 9.84 64 213747 2411 64282510
Platelet count decreased 75.45 9.84 293 213518 167418 64117503
Homicidal ideation 73.53 9.84 71 213740 3186 64281735
Tearfulness 73.51 9.84 84 213727 4589 64280332
Dyskinesia 71.24 9.84 289 213522 39099 64245822
Glossodynia 70.74 9.84 66 213745 64630 64220291
Stomatitis 69.77 9.84 163 213648 109442 64175479
Inappropriate antidiuretic hormone secretion 69.14 9.84 196 213615 22093 64262828
Alcoholism 68.83 9.84 70 213741 3347 64281574
Disinhibition 68.58 9.84 58 213753 2185 64282736
Abdominal discomfort 68.39 9.84 341 213470 181981 64102940
Muscle injury 68.34 9.84 5 213806 26432 64258489
Impulsive behaviour 67.69 9.84 62 213749 2601 64282320
Erectile dysfunction 67.32 9.84 137 213674 12490 64272431
Mucosal inflammation 67.07 9.84 65 213746 62519 64222402
Anger 67.05 9.84 156 213655 15585 64269336
Immunodeficiency 66.72 9.84 158 213653 15966 64268955
Sepsis 66.67 9.84 468 213343 229873 64055048
Psychomotor hyperactivity 65.75 9.84 147 213664 14304 64270617
Long QT syndrome 65.48 9.84 83 213728 5056 64279865
Sleep disorder due to general medical condition, insomnia type 65.05 9.84 6 213805 26264 64258657
Mood swings 64.66 9.84 164 213647 17304 64267617
Intrusive thoughts 64.18 9.84 29 213782 338 64284583
Memory impairment 64.09 9.84 495 213316 85187 64199734
Depressed level of consciousness 63.46 9.84 475 213336 80961 64203960
Disease progression 63.41 9.84 248 213563 141432 64143489
Galactorrhoea 63.12 9.84 65 213746 3154 64281767
C-reactive protein increased 62.97 9.84 138 213673 94771 64190150
Cardiac failure 62.96 9.84 226 213585 132147 64152774
Multiple organ dysfunction syndrome 62.03 9.84 154 213657 101259 64183662
Tachyphrenia 58.37 9.84 49 213762 1827 64283094
Wound 57.80 9.84 103 213708 76374 64208547
Drug resistance 57.74 9.84 22 213789 35080 64249841
Intentional product use issue 57.41 9.84 146 213665 95218 64189703
Bursitis 57.21 9.84 179 213632 21306 64263615
Renal impairment 56.87 9.84 242 213569 134775 64150146
Sexual dysfunction 56.27 9.84 87 213724 6384 64278537
Generalised tonic-clonic seizure 55.85 9.84 271 213540 39586 64245335
Orgasmic sensation decreased 54.99 9.84 15 213796 28 64284893
Self-injurious ideation 54.63 9.84 60 213751 3137 64281784
Disturbance in sexual arousal 54.49 9.84 21 213790 158 64284763
Disorientation 53.76 9.84 343 213468 55485 64229436
Depressive symptom 53.19 9.84 70 213741 4426 64280495
Drug dependence 52.19 9.84 234 213577 33078 64251843
Alcohol use 51.91 9.84 70 213741 4532 64280389
C-reactive protein abnormal 51.59 9.84 16 213795 29031 64255890
Yawning 51.29 9.84 38 213773 1178 64283743
Homicide 50.88 9.84 37 213774 1114 64283807
Hallucination, auditory 50.64 9.84 147 213664 16792 64268129
Amnesia 50.52 9.84 303 213508 47966 64236955
Anaemia 50.30 9.84 918 212893 377762 63907159
Parkinsonism 50.17 9.84 132 213679 14241 64270680
Dyspnoea 50.14 9.84 1913 211898 716761 63568160
Myocardial stunning 50.00 9.84 20 213791 168 64284753
Pneumocystis jirovecii pneumonia 49.48 9.84 15 213796 27619 64257302
Contraindicated product administered 49.36 9.84 187 213624 107642 64177279
Cardiac failure congestive 49.08 9.84 244 213567 130336 64154585
Cerebral vasoconstriction 48.90 9.84 37 213774 1185 64283736
Duodenal ulcer perforation 48.73 9.84 27 213784 34598 64250323
Drug screen positive 48.39 9.84 76 213735 5653 64279268
Drug reaction with eosinophilia and systemic symptoms 47.64 9.84 66 213745 54151 64230770
Dizziness 46.29 9.84 1803 212008 428360 63856561
Hallucination, visual 46.25 9.84 199 213612 27635 64257286
Pleural effusion 46.13 9.84 239 213572 126320 64158601
Bone marrow failure 45.61 9.84 55 213756 47897 64237024
Abnormal dreams 45.61 9.84 104 213707 10252 64274669
Nasopharyngitis 45.39 9.84 423 213388 195650 64089271
Diarrhoea 45.19 9.84 1948 211863 720756 63564165
Renal failure 44.67 9.84 386 213425 181302 64103619
Toxicologic test abnormal 44.45 9.84 35 213776 1190 64283731
Liver disorder 43.89 9.84 68 213743 53283 64231638
Mental disorder 43.88 9.84 189 213622 26256 64258665
Haemophagocytic lymphohistiocytosis 43.66 9.84 4 213807 17605 64267316
Atrial fibrillation 43.63 9.84 360 213451 170729 64114192
Psychiatric decompensation 43.43 9.84 47 213764 2416 64282505
Thinking abnormal 43.30 9.84 109 213702 11447 64273474
Medication error 43.28 9.84 299 213512 49667 64235254
Physical assault 43.26 9.84 38 213773 1508 64283413
Asphyxia 43.17 9.84 97 213714 9469 64275452
COVID-19 42.97 9.84 95 213716 65045 64219876
Haematemesis 42.96 9.84 285 213526 46714 64238207
Insomnia 42.74 9.84 906 212905 196930 64087991
Discomfort 42.62 9.84 132 213679 80746 64204175
Lethargy 42.45 9.84 397 213414 72197 64212724
Sinusitis 42.43 9.84 296 213515 145632 64139289
Panic reaction 42.03 9.84 59 213752 3968 64280953
Bradyphrenia 42.03 9.84 95 213716 9311 64275610
Alcohol abuse 41.87 9.84 65 213746 4787 64280134
Myelosuppression 40.78 9.84 14 213797 23816 64261105
Negative thoughts 40.13 9.84 34 213777 1284 64283637
Cytokine release syndrome 39.73 9.84 10 213801 20819 64264102
Psychomotor skills impaired 39.64 9.84 56 213755 3789 64281132
Major depression 39.55 9.84 83 213728 7733 64277188
Dissociation 38.95 9.84 49 213762 2962 64281959
Angle closure glaucoma 38.85 9.84 46 213765 2611 64282310
Folliculitis 38.77 9.84 26 213785 30051 64254870
Blister 37.32 9.84 140 213671 80827 64204094
Sedation 37.03 9.84 250 213561 41212 64243709
Bradycardia 37.03 9.84 574 213237 117645 64167276
Bronchopulmonary aspergillosis 36.72 9.84 9 213802 19076 64265845
Product use issue 36.54 9.84 324 213487 151391 64133530
Acute myeloid leukaemia 36.41 9.84 23 213788 27440 64257481
Mental impairment 36.24 9.84 128 213683 16215 64268706
Clonus 36.18 9.84 69 213742 5998 64278923
Nicotine dependence 35.60 9.84 26 213785 788 64284133
Calcium deficiency 35.55 9.84 25 213786 713 64284208
Premature ejaculation 35.41 9.84 12 213799 59 64284862
Increased appetite 35.23 9.84 93 213718 10053 64274868
Somnambulism 35.12 9.84 62 213749 5079 64279842
Swelling 34.81 9.84 351 213460 159867 64125054
Crying 34.43 9.84 145 213666 19945 64264976
Maternal exposure during pregnancy 34.42 9.84 182 213629 95702 64189219
Suicidal behaviour 34.23 9.84 45 213766 2842 64282079
Catatonia 34.09 9.84 77 213734 7543 64277378
Arthralgia 33.96 9.84 1163 212648 441097 63843824
Extrapyramidal disorder 33.42 9.84 141 213670 19411 64265510
Neuropathy peripheral 33.37 9.84 240 213571 117285 64167636
Abnormal behaviour 33.25 9.84 208 213603 33414 64251507
Logorrhoea 33.12 9.84 53 213758 4006 64280915
Hypertonia 32.98 9.84 68 213743 6257 64278664
Tic 32.90 9.84 42 213769 2577 64282344
Aspartate aminotransferase increased 32.88 9.84 247 213564 119541 64165380
Red blood cell sedimentation rate abnormal 32.75 9.84 7 213804 16299 64268622
Bradykinesia 32.42 9.84 69 213742 6491 64278430
Impaired healing 32.35 9.84 98 213713 60375 64224546
Tumour lysis syndrome 32.28 9.84 12 213799 19428 64265493
Blood creatinine increased 31.81 9.84 292 213519 135490 64149431
Urinary retention 31.79 9.84 275 213536 48926 64235995
Haematotoxicity 31.78 9.84 3 213808 12893 64272028
Prescription drug used without a prescription 31.57 9.84 41 213770 2559 64282362
Myelodysplastic syndrome 31.50 9.84 27 213784 27552 64257369
Myocardial infarction 31.35 9.84 375 213436 165446 64119475
Genital hypoaesthesia 31.23 9.84 14 213797 160 64284761
Pneumonitis 31.17 9.84 76 213735 50289 64234632
Palmar-plantar erythrodysaesthesia syndrome 30.80 9.84 30 213781 28789 64256132
Drug eruption 30.74 9.84 45 213766 36091 64248830
Irritable bowel syndrome 30.38 9.84 48 213763 37321 64247600
Neutrophil count decreased 30.30 9.84 142 213669 77054 64207867
Blood bilirubin increased 30.27 9.84 94 213717 57459 64227462
Rhinitis perennial 30.27 9.84 15 213796 218 64284703
Ill-defined disorder 30.08 9.84 63 213748 43989 64240932
Toxic epidermal necrolysis 29.97 9.84 48 213763 37118 64247803
Alcohol poisoning 29.95 9.84 52 213759 4203 64280718
Rabbit syndrome 29.89 9.84 17 213794 331 64284590
Hypomania 29.73 9.84 61 213750 5593 64279328
Antidepressant drug level above therapeutic 29.66 9.84 20 213791 532 64284389
Adrenal insufficiency 29.58 9.84 19 213792 22468 64262453
Illness anxiety disorder 29.38 9.84 15 213796 233 64284688
Apathy 29.37 9.84 93 213718 11139 64273782
Ascites 29.37 9.84 106 213705 61895 64223026
Hyperventilation 29.36 9.84 68 213743 6772 64278149
Post viral fatigue syndrome 29.25 9.84 16 213795 288 64284633
Antipsychotic drug level below therapeutic 29.16 9.84 25 213786 960 64283961
Spontaneous penile erection 29.09 9.84 12 213799 110 64284811
Prescribed overdose 29.03 9.84 139 213672 20192 64264729
Derealisation 28.98 9.84 30 213781 1465 64283456
Psychomotor retardation 28.85 9.84 57 213754 5086 64279835
Coma 28.82 9.84 429 213382 87186 64197735
Tardive dyskinesia 28.75 9.84 81 213730 9097 64275824
Female sexual arousal disorder 28.68 9.84 7 213804 6 64284915
Oedema peripheral 28.45 9.84 508 213303 209809 64075112
Eosinophilia 28.12 9.84 52 213759 38024 64246897
Hyponatraemic syndrome 28.12 9.84 22 213789 741 64284180
Osteonecrosis of jaw 28.01 9.84 56 213755 39769 64245152
Respiratory distress 27.86 9.84 85 213726 52246 64232675
Neoplasm progression 27.63 9.84 59 213752 40905 64244016
Pulseless electrical activity 27.59 9.84 99 213712 12640 64272281
Haematuria 27.58 9.84 105 213706 60366 64224555
Obesity 27.51 9.84 138 213673 20424 64264497
Skin ulcer 27.49 9.84 66 213745 43908 64241013
Hepatic enzyme increased 27.27 9.84 287 213524 129656 64155265
Neonatal infection 27.20 9.84 8 213803 22 64284899
Urticaria 27.14 9.84 335 213476 146982 64137939
Hostility 27.10 9.84 35 213776 2172 64282749
Product prescribing error 27.05 9.84 205 213606 35064 64249857
Transplant rejection 26.85 9.84 12 213799 17389 64267532
Posterior reversible encephalopathy syndrome 26.78 9.84 22 213789 22924 64261997
Euphoric mood 26.64 9.84 64 213747 6527 64278394
Pseudomonas infection 26.56 9.84 13 213798 17870 64267051
Poverty of speech 26.48 9.84 19 213792 560 64284361
Carcinoid heart disease 26.44 9.84 9 213802 45 64284876
Circulatory collapse 26.40 9.84 197 213614 33535 64251386
Sinus tachycardia 26.35 9.84 190 213621 31998 64252923
Therapeutic product effect incomplete 26.25 9.84 218 213593 103264 64181657
Postmortem blood drug level increased 26.03 9.84 21 213790 740 64284181
Lower respiratory tract infection 26.00 9.84 195 213616 94419 64190502
Myocardial fibrosis 25.87 9.84 29 213782 1551 64283370
Gun shot wound 25.55 9.84 24 213787 1040 64283881
Premature delivery 25.43 9.84 15 213796 18574 64266347
Forced expiratory volume 25.31 9.84 10 213801 81 64284840
Substance abuse 25.28 9.84 78 213733 9214 64275707
Syncope 25.26 9.84 693 213118 156942 64127979
Hospitalisation 25.21 9.84 146 213665 75061 64209860
Hyperprolactinaemia 25.19 9.84 47 213764 4018 64280903
Emotional distress 25.18 9.84 205 213606 35833 64249088
Restless legs syndrome 25.15 9.84 118 213693 16998 64267923
Injection site pain 25.06 9.84 242 213569 111166 64173755
Alcohol interaction 24.96 9.84 49 213762 4352 64280569
Drug hypersensitivity 24.90 9.84 599 213212 237216 64047705
Thrombotic microangiopathy 24.90 9.84 12 213799 16643 64268278
Arthritis 24.85 9.84 169 213642 83645 64201276
Orgasm abnormal 24.74 9.84 12 213799 166 64284755
Acute myocardial infarction 24.65 9.84 133 213678 69585 64215336
Enterocolitis 24.47 9.84 5 213806 12013 64272908
Incoherent 24.47 9.84 65 213746 7053 64277868
Rheumatoid nodule 24.27 9.84 6 213805 12645 64272276
Hypochloraemia 24.25 9.84 32 213779 2029 64282892
Optic ischaemic neuropathy 24.24 9.84 36 213775 2549 64282372
Radiologically isolated syndrome 24.14 9.84 6 213805 6 64284915
Liver function test increased 24.04 9.84 41 213770 30929 64253992
Delirium 24.02 9.84 342 213469 68852 64216069
Pathogen resistance 23.97 9.84 6 213805 12537 64272384
Parathyroid gland enlargement 23.84 9.84 11 213800 135 64284786
Flat affect 23.67 9.84 30 213781 1827 64283094
Knee arthroplasty 23.58 9.84 33 213778 26966 64257955
Tachycardia 23.52 9.84 656 213155 148923 64135998
Lactic acidosis 23.49 9.84 114 213697 61296 64223625
Cholecystitis chronic 23.47 9.84 76 213735 9211 64275710
Dystonia 23.43 9.84 124 213687 18741 64266180
Alanine aminotransferase increased 23.10 9.84 323 213488 138708 64146213
Cough 23.05 9.84 795 213016 301353 63983568
Foetal chromosome abnormality 22.81 9.84 6 213805 9 64284912
Dissociative amnesia 22.80 9.84 10 213801 108 64284813
Hypokinesia 22.64 9.84 112 213699 16484 64268437
Failure to suspend medication 22.55 9.84 15 213796 390 64284531
Panic disorder 22.49 9.84 36 213775 2721 64282200
Mental status changes 22.32 9.84 305 213506 60857 64224064
Disseminated intravascular coagulation 22.31 9.84 46 213765 32302 64252619
Neuropathy, ataxia, retinitis pigmentosa syndrome 22.29 9.84 8 213803 48 64284873
Atonic urinary bladder 22.25 9.84 9 213802 78 64284843
Rash erythematous 22.25 9.84 253 213558 48380 64236541
Hypercalcaemia 22.24 9.84 44 213767 31372 64253549
Nervousness 22.23 9.84 171 213640 29385 64255536
Anhidrosis 22.03 9.84 12 213799 214 64284707
Concussion 21.94 9.84 67 213744 7871 64277050
Personality change 21.43 9.84 70 213741 8523 64276398
Libido increased 21.38 9.84 28 213783 1762 64283159
Dreamy state 21.37 9.84 8 213803 55 64284866
Trisomy 18 21.22 9.84 5 213806 3 64284918
Brain injury 21.20 9.84 77 213734 9888 64275033
Tension 20.87 9.84 42 213769 3798 64281123
Schizoaffective disorder 20.81 9.84 26 213785 1561 64283360
White blood cell count decreased 20.78 9.84 383 213428 157454 64127467
Venoocclusive liver disease 20.74 9.84 4 213807 10011 64274910
Dry mouth 20.72 9.84 298 213513 60120 64224801
Neonatal seizure 20.64 9.84 5 213806 4 64284917
Antipsychotic drug level above therapeutic 20.52 9.84 28 213783 1833 64283088
Psoriatic arthropathy 20.49 9.84 74 213737 43207 64241714
Herpes zoster 20.45 9.84 166 213645 79021 64205900
Vascular access site thrombosis 20.40 9.84 7 213804 36 64284885
Social avoidant behaviour 20.33 9.84 46 213765 4511 64280410
Hanging 20.30 9.84 9 213802 100 64284821
Epstein-Barr virus infection 20.25 9.84 8 213803 12480 64272441
Pulmonary arterial hypertension 20.23 9.84 33 213778 25334 64259587
Hypocalcaemia 20.03 9.84 71 213740 41682 64243239
Loss of bladder sensation 20.02 9.84 8 213803 67 64284854
Activation syndrome 20.00 9.84 12 213799 259 64284662
Rash maculo-papular 19.96 9.84 84 213727 46942 64237979
Head injury 19.89 9.84 181 213630 32661 64252260
Poor quality sleep 19.85 9.84 119 213692 18832 64266089
Facial spasm 19.78 9.84 17 213794 655 64284266
Skin swelling 19.73 9.84 34 213777 2732 64282189
Acute generalised exanthematous pustulosis 19.72 9.84 11 213800 14047 64270874
Pupillary reflex impaired 19.64 9.84 36 213775 3037 64281884
Dementia 19.62 9.84 127 213684 20639 64264282
Hypogammaglobulinaemia 19.54 9.84 5 213806 10294 64274627
Histrionic personality disorder 19.51 9.84 7 213804 42 64284879
Interstitial granulomatous dermatitis 19.49 9.84 11 213800 211 64284710
Bronchomalacia 19.49 9.84 11 213800 211 64284710
Heat stroke 19.34 9.84 24 213787 1431 64283490
Personality disorder 19.31 9.84 46 213765 4665 64280256
Conduction disorder 19.26 9.84 35 213776 2933 64281988
Cerebrospinal fluid retention 19.24 9.84 8 213803 75 64284846
Hyperuricaemia 19.23 9.84 5 213806 10186 64274735
Opiates positive 19.20 9.84 19 213792 879 64284042
Cytomegalovirus viraemia 19.16 9.84 6 213805 10822 64274099
Cytopenia 19.11 9.84 14 213797 15457 64269464
Diaphragmatic rupture 19.08 9.84 11 213800 220 64284701
Obsessive thoughts 18.98 9.84 20 213791 997 64283924
Antidepressant drug level increased 18.92 9.84 13 213798 357 64284564
Rib deformity 18.92 9.84 9 213802 119 64284802
Epistaxis 18.89 9.84 221 213590 97910 64187011
Spermatozoa morphology abnormal 18.85 9.84 4 213807 0 64284921
Sexual inhibition 18.85 9.84 4 213807 0 64284921
Nocturnal emission 18.85 9.84 4 213807 0 64284921
Pruritus 18.81 9.84 845 212966 311555 63973366
Hip arthroplasty 18.75 9.84 26 213785 21325 64263596
Pregnancy 18.74 9.84 126 213685 20739 64264182
Polyneuropathy 18.73 9.84 23 213788 19871 64265050
Rheumatic fever 18.65 9.84 4 213807 9290 64275631
Cognitive disorder 18.61 9.84 271 213540 54816 64230105
Influenza 18.60 9.84 245 213566 106286 64178635
Gender dysphoria 18.60 9.84 7 213804 49 64284872
Decreased interest 18.56 9.84 37 213774 3323 64281598
Agoraphobia 18.51 9.84 15 213796 532 64284389
Drug-induced liver injury 18.48 9.84 88 213723 47555 64237366
Intestinal congestion 18.45 9.84 5 213806 9 64284912
Hyperbilirubinaemia 18.44 9.84 26 213785 21179 64263742
Dysarthria 18.42 9.84 288 213523 59118 64225803
Product dose omission issue 18.38 9.84 498 213313 194249 64090672
Psychiatric symptom 18.33 9.84 54 213757 6219 64278702
Thrombosis 18.28 9.84 148 213663 70494 64214427
Abnormal weight gain 18.20 9.84 29 213782 2184 64282737
Drug withdrawal syndrome neonatal 18.19 9.84 11 213800 241 64284680
Blood alcohol increased 18.18 9.84 21 213790 1161 64283760
Libido disorder 18.11 9.84 11 213800 243 64284678
Oedema 18.10 9.84 206 213605 91729 64193192
Muscle tightness 18.10 9.84 79 213732 11036 64273885
Dysphemia 18.02 9.84 35 213776 3084 64281837
Cataract 18.00 9.84 98 213713 51164 64233757
Pulmonary alveolar haemorrhage 17.96 9.84 5 213806 9733 64275188
Drug level above therapeutic 17.92 9.84 57 213754 6844 64278077
Menopause 17.79 9.84 25 213786 1683 64283238
Graft versus host disease 17.72 9.84 12 213799 13801 64271120
Fibromyalgia 17.65 9.84 60 213751 35671 64249250
Subclavian artery thrombosis 17.63 9.84 6 213805 30 64284891
Sputum purulent 17.55 9.84 21 213790 1205 64283716
Dermatitis bullous 17.55 9.84 9 213802 12045 64272876
Delusion 17.54 9.84 111 213700 17903 64267018
Genital anaesthesia 17.48 9.84 5 213806 12 64284909
Chronic spontaneous urticaria 17.46 9.84 14 213797 489 64284432
Hypersexuality 17.45 9.84 23 213788 1456 64283465
Speech disorder 17.44 9.84 241 213570 48200 64236721
Cholangitis 17.38 9.84 7 213804 10795 64274126
Kidney transplant rejection 17.32 9.84 5 213806 9506 64275415
Semen volume decreased 17.28 9.84 7 213804 61 64284860
Sexual relationship change 17.20 9.84 5 213806 13 64284908
Vasoplegia syndrome 17.16 9.84 32 213779 2735 64282186
Bacteraemia 17.13 9.84 40 213771 26871 64258050
Hypersomnia 17.08 9.84 118 213693 19599 64265322
Cystoid macular oedema 17.06 9.84 25 213786 1749 64283172
Chronic kidney disease 17.06 9.84 117 213694 57802 64227119
Right ventricular failure 17.06 9.84 28 213783 21443 64263478
Cystitis haemorrhagic 16.85 9.84 3 213808 7953 64276968
Bipolar disorder 16.79 9.84 55 213756 6706 64278215
Oropharyngeal pain 16.77 9.84 201 213610 88666 64196255
Localised infection 16.77 9.84 48 213763 30113 64254808
Morbid thoughts 16.72 9.84 16 213795 710 64284211
Injection site erythema 16.68 9.84 152 213659 70648 64214273
Aplastic anaemia 16.68 9.84 13 213798 13907 64271014
Condition aggravated 16.65 9.84 1038 212773 371388 63913533
Electrolyte substitution therapy 16.62 9.84 4 213807 3 64284918
Amputation stump pain 16.58 9.84 6 213805 37 64284884
Sternal fracture 16.53 9.84 28 213783 2219 64282702
CYP3A4 polymorphism 16.44 9.84 7 213804 70 64284851
Red blood cell sedimentation rate increased 16.43 9.84 51 213760 31184 64253737
Aspergillus infection 16.43 9.84 18 213793 16361 64268560
Wrong technique in product usage process 16.42 9.84 137 213674 64837 64220084
Legal problem 16.30 9.84 9 213802 165 64284756
Atrophic vulvovaginitis 16.26 9.84 20 213791 1181 64283740
Accidental poisoning 16.24 9.84 22 213789 1431 64283490
Bronchitis 16.21 9.84 258 213553 108485 64176436
Meningitis streptococcal 16.21 9.84 9 213802 167 64284754
Upper respiratory fungal infection 16.20 9.84 11 213800 296 64284625
Sexually inappropriate behaviour 16.19 9.84 13 213798 455 64284466
Incontinence 16.11 9.84 81 213730 12000 64272921
Hepatocellular carcinoma 16.09 9.84 4 213807 8399 64276522
Hypoalbuminaemia 16.05 9.84 21 213790 17653 64267268
Therapy interrupted 16.04 9.84 26 213785 20010 64264911
Drug abuser 16.03 9.84 49 213762 5759 64279162
CFTR gene mutation 15.93 9.84 7 213804 76 64284845
Mood altered 15.89 9.84 99 213712 15880 64269041
Tuberculosis 15.85 9.84 12 213799 13026 64271895
Polymenorrhagia 15.82 9.84 6 213805 43 64284878
Lung disorder 15.79 9.84 127 213684 60573 64224348
Multiple sclerosis relapse 15.78 9.84 207 213604 40928 64243993
Basal cell carcinoma 15.77 9.84 51 213760 30787 64254134
Respiratory tract infection 15.76 9.84 67 213744 37340 64247581
Post-traumatic neck syndrome 15.74 9.84 25 213786 1877 64283044
Metastases to liver 15.71 9.84 35 213776 23906 64261015
Cardiac steatosis 15.70 9.84 6 213805 44 64284877
Coordination abnormal 15.70 9.84 94 213717 14870 64270051
Pneumonia bacterial 15.66 9.84 16 213795 15019 64269902
Basal ganglion degeneration 15.55 9.84 12 213799 396 64284525
Meconium in amniotic fluid 15.54 9.84 7 213804 81 64284840
Violence-related symptom 15.41 9.84 15 213796 680 64284241
Asthma 15.35 9.84 419 213392 94806 64190115
Lipoedema 15.22 9.84 9 213802 189 64284732
Sensory disturbance 15.18 9.84 85 213726 13123 64271798
Hypersensitivity 15.17 9.84 516 213295 195936 64088985
Renal disorder 15.12 9.84 63 213748 35302 64249619
Mucormycosis 15.06 9.84 3 213808 7338 64277583
Blunted affect 15.04 9.84 12 213799 416 64284505
Pulmonary oedema 14.98 9.84 354 213457 78320 64206601
End stage renal disease 14.98 9.84 8 213803 10467 64274454
Dermatillomania 14.97 9.84 9 213802 195 64284726
Job dissatisfaction 14.94 9.84 6 213805 51 64284870
Antipsychotic drug level increased 14.92 9.84 44 213767 5071 64279850
Balance disorder 14.89 9.84 374 213437 83552 64201369
Dysponesis 14.83 9.84 4 213807 7 64284914
Soft tissue injury 14.82 9.84 22 213789 1557 64283364
Adenovirus infection 14.81 9.84 3 213808 7252 64277669
Throat irritation 14.79 9.84 57 213754 32654 64252267
Proteinuria 14.77 9.84 45 213766 27678 64257243
Vascular access site infection 14.75 9.84 7 213804 92 64284829
Pulmonary toxicity 14.70 9.84 5 213806 8556 64276365
Caesarean section 14.62 9.84 75 213736 11199 64273722
Dysaesthesia 14.60 9.84 43 213768 4952 64279969
Parkinson's disease 14.59 9.84 22 213789 1579 64283342
Toxic skin eruption 14.54 9.84 26 213785 19258 64265663
Heparin-induced thrombocytopenia 14.48 9.84 5 213806 8474 64276447
Haemoglobin decreased 14.45 9.84 515 213296 194548 64090373
Nystagmus 14.43 9.84 64 213747 9004 64275917
Self-medication 14.40 9.84 38 213773 4107 64280814
Polyhydramnios 14.37 9.84 21 213790 1466 64283455
Organising pneumonia 14.36 9.84 6 213805 9049 64275872
Gestational diabetes 14.36 9.84 46 213765 5544 64279377
Ejection fraction decreased 14.32 9.84 48 213763 28659 64256262
Bipolar I disorder 14.28 9.84 23 213788 1748 64283173
Hypervigilance 14.24 9.84 12 213799 450 64284471
Female orgasmic disorder 14.22 9.84 5 213806 28 64284893
Gas poisoning 14.14 9.84 3 213808 0 64284921
New daily persistent headache 14.14 9.84 3 213808 0 64284921
Vertigo CNS origin 14.08 9.84 5 213806 29 64284892
Hyperkinesia 14.02 9.84 28 213783 2518 64282403
Posturing 13.94 9.84 17 213794 995 64283926
Uterine enlargement 13.94 9.84 15 213796 766 64284155
Hallucinations, mixed 13.94 9.84 48 213763 6004 64278917
Multiple drug therapy 13.89 9.84 26 213785 2228 64282693
Respiratory tract congestion 13.88 9.84 20 213791 16145 64268776
Injection site reaction 13.87 9.84 94 213717 46570 64238351
Feeling of despair 13.85 9.84 28 213783 2540 64282381
Fear 13.69 9.84 114 213697 20057 64264864
Acute graft versus host disease in skin 13.65 9.84 3 213808 6852 64278069
Haemolysis 13.62 9.84 10 213801 11029 64273892
Blood uric acid increased 13.62 9.84 5 213806 8158 64276763
Self esteem decreased 13.61 9.84 16 213795 901 64284020
Oliguria 13.56 9.84 17 213794 14559 64270362
Hypervolaemia 13.55 9.84 73 213738 38212 64246709
Acute stress disorder 13.53 9.84 11 213800 392 64284529
Hepatocellular injury 13.51 9.84 91 213720 45144 64239777
Vaginal haemorrhage 13.49 9.84 110 213701 19234 64265687
Bladder cancer 13.47 9.84 10 213801 10964 64273957
Injection site pruritus 13.46 9.84 72 213739 37754 64247167
Musculoskeletal pain 13.45 9.84 189 213622 81105 64203816
Ventricular tachycardia 13.38 9.84 173 213638 34092 64250829
Maternal exposure during breast feeding 13.37 9.84 24 213787 1992 64282929
Labelled drug-drug interaction issue 13.31 9.84 11 213800 401 64284520
Adrenergic syndrome 13.31 9.84 7 213804 116 64284805
Vertigo 13.29 9.84 272 213539 58739 64226182
Neuroleptic malignant syndrome 13.28 9.84 134 213677 24862 64260059
Coronary artery disease 13.28 9.84 132 213679 60301 64224620
Productive cough 13.27 9.84 167 213644 73036 64211885
Lymphoma 13.25 9.84 16 213795 13925 64270996
Mutism 13.21 9.84 24 213787 2010 64282911
Acute respiratory failure 13.20 9.84 104 213707 49830 64235091
Trismus 13.20 9.84 41 213770 4860 64280061
Therapeutic response decreased 13.20 9.84 110 213701 52078 64232843
Movement disorder 13.20 9.84 121 213690 21879 64263042
Saliva altered 13.11 9.84 11 213800 410 64284511
Executive dysfunction 13.10 9.84 9 213802 247 64284674
Hepatitis C virus test positive 13.09 9.84 10 213801 325 64284596
Polyarthritis 13.07 9.84 8 213803 9707 64275214
Metastases to lung 12.99 9.84 19 213792 15245 64269676
Product storage error 12.96 9.84 15 213796 13303 64271618
Injection site swelling 12.95 9.84 82 213729 41271 64243650
Prostate cancer 12.94 9.84 29 213782 19766 64265155
Agranulocytosis 12.92 9.84 74 213737 38155 64246766
Blood catecholamines decreased 12.88 9.84 4 213807 14 64284907
Haematospermia 12.85 9.84 9 213802 255 64284666
Device related infection 12.82 9.84 55 213756 30571 64254350
Osmotic demyelination syndrome 12.80 9.84 18 213793 1213 64283708
Stoma site infection 12.75 9.84 18 213793 1217 64283704
Cellulitis 12.72 9.84 226 213585 93431 64191490
Pneumonia viral 12.70 9.84 5 213806 7817 64277104
Exposure to allergen 12.70 9.84 8 213803 189 64284732
Intervertebral disc disorder 12.67 9.84 38 213773 4419 64280502
Drug level increased 12.67 9.84 171 213640 34025 64250896
Respiratory depression 12.61 9.84 126 213685 23317 64261604
Wrong patient received product 12.57 9.84 34 213777 3728 64281193
Osmolar gap abnormal 12.57 9.84 6 213805 80 64284841
Cholestasis 12.55 9.84 92 213719 44780 64240141
Gastrointestinal mucosal exfoliation 12.55 9.84 8 213803 193 64284728
Affect lability 12.50 9.84 61 213750 8929 64275992
Sleep disorder 12.41 9.84 272 213539 59437 64225484
Panniculitis 12.38 9.84 7 213804 8872 64276049
Tobacco user 12.37 9.84 13 213798 646 64284275
Anaphylactic shock 12.37 9.84 55 213756 30273 64254648
Systolic hypertension 12.35 9.84 13 213798 647 64284274
Ventricular arrhythmia 12.30 9.84 53 213758 7362 64277559
Hypocoagulable state 12.21 9.84 22 213789 1831 64283090
Antisocial behaviour 12.20 9.84 12 213799 551 64284370
Hypoxia 12.20 9.84 212 213599 87937 64196984
Paraesthesia 12.18 9.84 554 213257 133968 64150953
Acute hepatic failure 12.13 9.84 45 213766 26067 64258854
Electrocardiogram QT interval abnormal 12.12 9.84 9 213802 280 64284641
Cushingoid 12.12 9.84 5 213806 7598 64277323
Dysphoria 12.09 9.84 37 213774 4351 64280570
Somatic symptom disorder 12.08 9.84 22 213789 1846 64283075
Skin laceration 12.07 9.84 129 213682 24288 64260633
Cervix haematoma uterine 12.07 9.84 3 213808 3 64284918
Bisexuality 12.07 9.84 3 213808 3 64284918
Antidepressant drug level below therapeutic 12.07 9.84 3 213808 3 64284918
Azoospermia 12.05 9.84 7 213804 142 64284779
Therapy cessation 12.03 9.84 61 213750 32428 64252493
Cardiac tamponade 12.03 9.84 6 213805 8158 64276763
Pleurisy 12.02 9.84 8 213803 9283 64275638
Oesophageal perforation 12.00 9.84 16 213795 1025 64283896
Hepatitis fulminant 11.99 9.84 3 213808 6271 64278650
Drug dose titration not performed 11.99 9.84 13 213798 670 64284251
Economic problem 11.98 9.84 24 213787 2163 64282758
Marital problem 11.86 9.84 8 213803 213 64284708
COVID-19 pneumonia 11.78 9.84 23 213788 16481 64268440
Diffuse large B-cell lymphoma stage II 11.76 9.84 6 213805 93 64284828
Metastases to bone 11.75 9.84 32 213779 20403 64264518
Facial paralysis 11.73 9.84 105 213706 18861 64266060
Tissue infiltration 11.67 9.84 12 213799 581 64284340
Male orgasmic disorder 11.65 9.84 5 213806 51 64284870
Pain 11.63 9.84 1633 212178 551878 63733043
Feeling guilty 11.62 9.84 14 213797 809 64284112
JC virus CSF test positive 11.59 9.84 7 213804 153 64284768
Anaphylactic reaction 11.59 9.84 159 213652 68505 64216416
Adjusted calcium increased 11.57 9.84 5 213806 52 64284869
Myositis 11.54 9.84 23 213788 16354 64268567
Pyelonephritis 11.53 9.84 25 213786 17241 64267680
Hypertension 11.50 9.84 723 213088 258538 64026383
Blood osmolarity decreased 11.48 9.84 17 213794 1201 64283720
Shock haemorrhagic 11.47 9.84 24 213787 16767 64268154
Adjustment disorder 11.47 9.84 27 213784 2718 64282203
Unintentional medical device removal 11.45 9.84 4 213807 6730 64278191
Osteoporosis 11.43 9.84 87 213724 41993 64242928
Thirst 11.31 9.84 83 213728 14054 64270867
Differential white blood cell count abnormal 11.31 9.84 21 213790 1789 64283132
Amniorrhexis 11.29 9.84 4 213807 23 64284898
Detoxification 11.27 9.84 6 213805 102 64284819
Pemphigoid 11.21 9.84 16 213795 12970 64271951
Accommodation disorder 11.18 9.84 11 213800 505 64284416
Bipolar II disorder 11.18 9.84 9 213802 316 64284605
Clostridium difficile infection 11.18 9.84 72 213739 36091 64248830
Pain in extremity 11.17 9.84 859 212952 302226 63982695
Nephropathy 11.15 9.84 7 213804 8379 64276542
Peripheral ischaemia 11.13 9.84 7 213804 8371 64276550
Musculoskeletal stiffness 11.11 9.84 317 213494 122889 64162032
Social problem 11.07 9.84 17 213794 1240 64283681
Hepatic steatosis 11.05 9.84 154 213657 30853 64254068
Decreased appetite 11.04 9.84 793 213018 280496 64004425
Poor personal hygiene 11.02 9.84 11 213800 514 64284407
Hypoxic-ischaemic encephalopathy 11.02 9.84 50 213761 7102 64277819
Neurotoxicity 10.99 9.84 50 213761 27354 64257567
Peritoneal perforation 10.98 9.84 7 213804 169 64284752
Product administration error 10.98 9.84 140 213671 27503 64257418
Therapy non-responder 10.98 9.84 153 213658 65746 64219175
Spermatozoa progressive motility decreased 10.94 9.84 5 213806 60 64284861
Sebaceous gland infection 10.87 9.84 6 213805 110 64284811
Alcoholic psychosis 10.86 9.84 3 213808 6 64284915
Leukopenia 10.86 9.84 254 213557 100988 64183933
Pelvic fracture 10.85 9.84 66 213745 10497 64274424
Slow response to stimuli 10.85 9.84 19 213792 1546 64283375
Testicular atrophy 10.78 9.84 9 213802 333 64284588
Joint ankylosis 10.73 9.84 13 213798 756 64284165
Infective pulmonary exacerbation of cystic fibrosis 10.73 9.84 14 213797 11782 64273139
Body dysmorphic disorder 10.71 9.84 8 213803 251 64284670
Coronary artery bypass 10.70 9.84 3 213808 5812 64279109
Swollen tongue 10.66 9.84 169 213642 34785 64250136
Persistent depressive disorder 10.66 9.84 15 213796 1011 64283910
Atrial flutter 10.66 9.84 31 213780 19349 64265572
Blood ethanol increased 10.64 9.84 12 213799 646 64284275
Hypoglycaemia 10.63 9.84 381 213430 89511 64195410
Stiff person syndrome 10.63 9.84 8 213803 254 64284667
Product substitution issue 10.59 9.84 98 213713 17763 64267158
Eye haematoma 10.59 9.84 6 213805 116 64284805
Feeling abnormal 10.57 9.84 543 213268 133059 64151862
Therapy partial responder 10.57 9.84 11 213800 10237 64274684
Pneumothorax 10.56 9.84 43 213768 24255 64260666
Orthostatic intolerance 10.55 9.84 19 213792 1581 64283340
Jaundice cholestatic 10.51 9.84 8 213803 8662 64276259
Akinesia 10.46 9.84 28 213783 3051 64281870
Surgery 10.43 9.84 53 213758 28160 64256761
Infected dermal cyst 10.42 9.84 13 213798 779 64284142
Ocular hyperaemia 10.40 9.84 39 213772 22525 64262396
Nephropathy toxic 10.39 9.84 27 213784 17487 64267434
Carbon monoxide poisoning 10.37 9.84 8 213803 264 64284657
Vaginal discharge 10.36 9.84 33 213778 3964 64280957
Agonal rhythm 10.32 9.84 5 213806 69 64284852
Blood urea increased 10.31 9.84 95 213716 44058 64240863
Bone erosion 10.30 9.84 14 213797 11581 64273340
Post-traumatic stress disorder 10.26 9.84 34 213777 4171 64280750
Tricuspid valve incompetence 10.25 9.84 26 213785 16977 64267944
Extensor plantar response 10.21 9.84 19 213792 1621 64283300
Gastrointestinal disorder 10.21 9.84 223 213588 89486 64195435
Reflexes abnormal 10.19 9.84 13 213798 797 64284124
Epilepsy 10.18 9.84 162 213649 33369 64251552
Hypokalaemia 10.17 9.84 498 213313 121405 64163516
Blood lactate dehydrogenase increased 10.15 9.84 66 213745 33012 64251909
Cardiac failure chronic 10.15 9.84 9 213802 9032 64275889
Diabetes mellitus 10.14 9.84 157 213654 66317 64218604
Miosis 10.11 9.84 77 213734 13189 64271732
Inguinal mass 10.10 9.84 7 213804 195 64284726
Feeling of body temperature change 10.07 9.84 37 213774 4777 64280144
Thrombotic stroke 10.02 9.84 12 213799 689 64284232
Potentiating drug interaction 10.02 9.84 52 213759 7800 64277121
Borderline personality disorder 10.01 9.84 13 213798 811 64284110
Schizoaffective disorder depressive type 10.01 9.84 3 213808 9 64284912
Genito-pelvic pain/penetration disorder 10.01 9.84 3 213808 9 64284912
Angiodermatitis 10.01 9.84 5 213806 74 64284847
Unevaluable event 9.99 9.84 113 213698 50376 64234545
Injection site bruising 9.97 9.84 75 213736 36298 64248623
Phobia 9.88 9.84 9 213802 375 64284546
Heterophoria 9.86 9.84 4 213807 35 64284886
Psychogenic seizure 9.84 9.84 20 213791 1821 64283100

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cryptorchism 33.71 29.95 38 1407 371 82862
Respiratory disorder neonatal 31.87 29.95 78 1367 1529 81704

Pharmacologic Action:

SourceCodeDescription
ATC N06AB04 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:50949 SSRI
CHEBI has role CHEBI:76779 post-proline endopeptidase inhibitors
CHEBI has role CHEBI:77402 EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitors
CHEBI has role CHEBI:78298 environmental contaminants
FDA EPC N0000175696 Serotonin Reuptake Inhibitor
MeSH PA D000928 Antidepressive Agents
MeSH PA D018687 Antidepressive Agents, Second-Generation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D017367 Serotonin Uptake Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Depressive disorder indication 35489007
Major depressive disorder indication 370143000
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Obsessive-compulsive disorder off-label use 191736004 DOID:10933
Menopausal flushing off-label use 198436008
Panic disorder off-label use 371631005 DOID:594
Suicidal thoughts contraindication 6471006
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Torsades de pointes contraindication 31722008
Upper gastrointestinal hemorrhage contraindication 37372002
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Heart disease contraindication 56265001 DOID:114
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Epilepsy contraindication 84757009 DOID:1826
Hyponatremia contraindication 89627008
Prolonged QT interval contraindication 111975006
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Serotonin syndrome contraindication 371089000
Myocardial infarction in recovery phase contraindication 418044006
Poor metabolizer due to cytochrome p450 CYP2C19 variant contraindication 424500005
Congenital long QT syndrome contraindication 442917000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 8.94 WOMBAT-PK CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.78 DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.40 WOMBAT-PK
Sodium-dependent noradrenaline transporter Transporter Ki 5.21 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 5.19 PDSP
5-hydroxytryptamine receptor 2B GPCR Ki 5.93 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.21 WOMBAT-PK
Histamine H1 receptor GPCR Ki 6.46 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 5.88 PDSP
Sodium-dependent dopamine transporter Transporter Ki 4.78 CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 6.15 DRUG MATRIX
Acetylcholinesterase Enzyme IC50 4.13 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.73 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 8.54 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 5.74 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 5.76 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 4.30 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 8.82 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 5.03 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.54 CHEMBL
Transporter Transporter Ki 5.23 CHEMBL
Transporter Transporter Ki 5.21 CHEMBL
Sigma intracellular receptor 2 Unclassified Ki 5.27 CHEMBL

External reference:

IDSource
4021129 VUID
N0000148583 NUI
D00822 KEGG_DRUG
59729-32-7 SECONDARY_CAS_RN
221078 RXNORM
4021129 VANDF
4021130 VANDF
C0008845 UMLSCUI
CHEBI:3723 CHEBI
CHEMBL549 ChEMBL_ID
CHEMBL399730 ChEMBL_ID
DB00215 DRUGBANK_ID
CHEMBL1200781 ChEMBL_ID
D015283 MESH_DESCRIPTOR_UI
2771 PUBCHEM_CID
7547 IUPHAR_LIGAND_ID
4138 INN_ID
0DHU5B8D6V UNII
21814 MMSL
62559 MMSL
7486 MMSL
d04332 MMSL
005106 NDDF
005107 NDDF
116521005 SNOMEDCT_US
321986007 SNOMEDCT_US
372596005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0054-0062 SOLUTION 10 mg ORAL ANDA 27 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0121-0848 SOLUTION 10 mg ORAL ANDA 32 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0121-1696 SOLUTION 20 mg ORAL ANDA 32 sections
Citalopram Human Prescription Drug Label 1 0185-0371 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Citalopram Human Prescription Drug Label 1 0185-0372 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
Citalopram Human Prescription Drug Label 1 0185-0373 TABLET, FILM COATED 40 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6231 TABLET, FILM COATED 10 mg ORAL ANDA 39 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6231 TABLET, FILM COATED 10 mg ORAL ANDA 39 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6232 TABLET, FILM COATED 20 mg ORAL ANDA 39 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6232 TABLET, FILM COATED 20 mg ORAL ANDA 39 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6233 TABLET, FILM COATED 40 mg ORAL ANDA 39 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6233 TABLET, FILM COATED 40 mg ORAL ANDA 39 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4010 TABLET, FILM COATED 10 mg ORAL NDA 35 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4010 TABLET, FILM COATED 10 mg ORAL NDA 35 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4020 TABLET, FILM COATED 20 mg ORAL NDA 35 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4020 TABLET, FILM COATED 20 mg ORAL NDA 35 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4040 TABLET, FILM COATED 40 mg ORAL NDA 35 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4040 TABLET, FILM COATED 40 mg ORAL NDA 35 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8022 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8023 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8141 TABLET, FILM COATED 40 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0713-4740 TABLET 10 mg ORAL ANDA 19 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0713-4741 TABLET 20 mg ORAL ANDA 19 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0713-4742 TABLET 40 mg ORAL ANDA 19 sections
Citalopram Hydrobromide HUMAN PRESCRIPTION DRUG LABEL 1 0904-6084 TABLET 10 mg ORAL ANDA 25 sections
Citalopram Hydrobromide HUMAN PRESCRIPTION DRUG LABEL 1 0904-6085 TABLET 20 mg ORAL ANDA 25 sections
Citalopram Hydrobromide HUMAN PRESCRIPTION DRUG LABEL 1 0904-6086 TABLET 40 mg ORAL ANDA 25 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 10544-006 TABLET 20 mg ORAL ANDA 32 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 10544-149 TABLET 20 mg ORAL ANDA 34 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 10544-150 TABLET 40 mg ORAL ANDA 34 sections