Stem definition | Drug id | CAS RN |
---|---|---|
663 | 59729-33-8 |
Dose | Unit | Route |
---|---|---|
20 | mg | O |
20 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.03 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 12 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 2.64 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 12 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 4.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.20 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 33 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
July 17, 1998 | FDA | FOREST LABS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1220.36 | 9.41 | 1874 | 175068 | 130015 | 50298167 |
Toxicity to various agents | 1146.01 | 9.41 | 2384 | 174558 | 210115 | 50218067 |
Drug abuse | 989.01 | 9.41 | 1131 | 175811 | 58715 | 50369467 |
Serotonin syndrome | 573.59 | 9.41 | 560 | 176382 | 24153 | 50404029 |
Electrocardiogram QT prolonged | 557.68 | 9.41 | 792 | 176150 | 51094 | 50377088 |
Drug interaction | 460.63 | 9.41 | 1639 | 175303 | 197982 | 50230200 |
Overdose | 455.34 | 9.41 | 1048 | 175894 | 98679 | 50329503 |
Intentional overdose | 438.22 | 9.41 | 785 | 176157 | 61719 | 50366463 |
Systemic lupus erythematosus | 372.86 | 9.41 | 32 | 176910 | 140590 | 50287592 |
Pemphigus | 365.97 | 9.41 | 12 | 176930 | 120154 | 50308028 |
Suicide attempt | 361.66 | 9.41 | 649 | 176293 | 51083 | 50377099 |
Drug ineffective | 361.50 | 9.41 | 1560 | 175382 | 817773 | 49610409 |
Synovitis | 352.08 | 9.41 | 20 | 176922 | 123845 | 50304337 |
Hand deformity | 324.44 | 9.41 | 5 | 176937 | 100194 | 50327988 |
Sopor | 316.76 | 9.41 | 369 | 176573 | 19510 | 50408672 |
Suicidal ideation | 300.30 | 9.41 | 624 | 176318 | 54761 | 50373421 |
Agitation | 283.07 | 9.41 | 596 | 176346 | 52788 | 50375394 |
Treatment failure | 278.72 | 9.41 | 69 | 176873 | 137568 | 50290614 |
Intentional self-injury | 244.05 | 9.41 | 350 | 176592 | 22762 | 50405420 |
Drug intolerance | 239.15 | 9.41 | 248 | 176694 | 218856 | 50209326 |
Hyponatraemia | 238.28 | 9.41 | 809 | 176133 | 95330 | 50332852 |
Pericarditis | 235.56 | 9.41 | 9 | 176933 | 78680 | 50349502 |
Glossodynia | 229.99 | 9.41 | 60 | 176882 | 115509 | 50312673 |
Alopecia | 223.45 | 9.41 | 319 | 176623 | 244728 | 50183454 |
Anti-cyclic citrullinated peptide antibody positive | 222.48 | 9.41 | 5 | 176937 | 70582 | 50357600 |
Torsade de pointes | 216.37 | 9.41 | 236 | 176706 | 11599 | 50416583 |
Temperature regulation disorder | 205.51 | 9.41 | 147 | 176795 | 4080 | 50424102 |
Anxiety | 203.91 | 9.41 | 1187 | 175755 | 176419 | 50251763 |
Respiratory arrest | 201.41 | 9.41 | 370 | 176572 | 29639 | 50398543 |
Infusion related reaction | 196.41 | 9.41 | 182 | 176760 | 169375 | 50258807 |
Arthropathy | 189.47 | 9.41 | 164 | 176778 | 157742 | 50270440 |
Cardio-respiratory arrest | 188.51 | 9.41 | 512 | 176430 | 53380 | 50374802 |
Poisoning | 186.88 | 9.41 | 224 | 176718 | 12205 | 50415977 |
Abdominal discomfort | 171.98 | 9.41 | 344 | 176598 | 231297 | 50196885 |
Rash | 169.94 | 9.41 | 870 | 176072 | 436601 | 49991581 |
Tremor | 168.72 | 9.41 | 822 | 176120 | 114081 | 50314101 |
Off label use | 167.56 | 9.41 | 974 | 175968 | 473452 | 49954730 |
Therapeutic product effect decreased | 159.94 | 9.41 | 144 | 176798 | 135906 | 50292276 |
Wound | 158.67 | 9.41 | 86 | 176856 | 105708 | 50322474 |
Rheumatoid factor positive | 155.32 | 9.41 | 4 | 176938 | 49855 | 50378327 |
Contraindicated product administered | 153.14 | 9.41 | 177 | 176765 | 148781 | 50279401 |
Panic attack | 152.50 | 9.41 | 256 | 176686 | 19086 | 50409096 |
Joint swelling | 152.39 | 9.41 | 401 | 176541 | 244885 | 50183297 |
Helicobacter infection | 141.24 | 9.41 | 8 | 176934 | 49694 | 50378488 |
Hyperhidrosis | 137.20 | 9.41 | 648 | 176294 | 88778 | 50339404 |
Duodenal ulcer perforation | 133.87 | 9.41 | 6 | 176936 | 45605 | 50382577 |
Food allergy | 129.53 | 9.41 | 151 | 176791 | 7986 | 50420196 |
Discomfort | 125.83 | 9.41 | 116 | 176826 | 108264 | 50319918 |
Cardiac arrest | 125.30 | 9.41 | 602 | 176340 | 83049 | 50345133 |
Foetal exposure during pregnancy | 118.63 | 9.41 | 282 | 176660 | 27077 | 50401105 |
Mydriasis | 112.27 | 9.41 | 161 | 176781 | 10466 | 50417716 |
Swelling | 111.04 | 9.41 | 347 | 176595 | 200525 | 50227657 |
Akathisia | 110.32 | 9.41 | 140 | 176802 | 8089 | 50420093 |
Infection | 110.21 | 9.41 | 279 | 176663 | 172675 | 50255507 |
Coeliac disease | 108.98 | 9.41 | 143 | 176799 | 8542 | 50419640 |
Disturbance in attention | 108.73 | 9.41 | 296 | 176646 | 30890 | 50397292 |
Fall | 106.59 | 9.41 | 1703 | 175239 | 333229 | 50094953 |
Somnolence | 106.08 | 9.41 | 914 | 176028 | 154071 | 50274111 |
Accidental overdose | 105.71 | 9.41 | 220 | 176722 | 19313 | 50408869 |
Myoclonus | 105.50 | 9.41 | 185 | 176757 | 14285 | 50413897 |
Muscle injury | 105.36 | 9.41 | 6 | 176936 | 37105 | 50391077 |
Withdrawal syndrome | 103.36 | 9.41 | 205 | 176737 | 17385 | 50410797 |
Bruxism | 102.36 | 9.41 | 85 | 176857 | 2955 | 50425227 |
Irritability | 102.32 | 9.41 | 273 | 176669 | 28153 | 50400029 |
Electrocardiogram QRS complex prolonged | 101.94 | 9.41 | 109 | 176833 | 5235 | 50422947 |
Maternal exposure during pregnancy | 101.59 | 9.41 | 258 | 176684 | 159520 | 50268662 |
Depression | 101.17 | 9.41 | 952 | 175990 | 164471 | 50263711 |
Febrile neutropenia | 97.18 | 9.41 | 119 | 176823 | 97548 | 50330634 |
Seizure | 96.33 | 9.41 | 724 | 176218 | 117150 | 50311032 |
Sleep disorder due to general medical condition, insomnia type | 96.18 | 9.41 | 3 | 176939 | 31444 | 50396738 |
Restlessness | 94.93 | 9.41 | 246 | 176696 | 24927 | 50403255 |
Peripheral swelling | 94.33 | 9.41 | 385 | 176557 | 205551 | 50222631 |
Folliculitis | 91.25 | 9.41 | 14 | 176928 | 39211 | 50388971 |
Unresponsive to stimuli | 90.68 | 9.41 | 274 | 176668 | 30335 | 50397847 |
Drug withdrawal syndrome | 89.38 | 9.41 | 240 | 176702 | 24841 | 50403341 |
Anorgasmia | 89.08 | 9.41 | 42 | 176900 | 513 | 50427669 |
Aggression | 88.69 | 9.41 | 215 | 176727 | 20901 | 50407281 |
Product use issue | 82.71 | 9.41 | 258 | 176684 | 149217 | 50278965 |
Confusional state | 79.78 | 9.41 | 997 | 175945 | 184931 | 50243251 |
Nightmare | 75.43 | 9.41 | 171 | 176771 | 15915 | 50412267 |
Long QT syndrome | 74.03 | 9.41 | 70 | 176872 | 2897 | 50425285 |
Pyrexia | 73.83 | 9.41 | 913 | 176029 | 379290 | 50048892 |
Sinusitis | 73.68 | 9.41 | 326 | 176616 | 170232 | 50257950 |
Impaired healing | 72.66 | 9.41 | 82 | 176860 | 69704 | 50358478 |
Immunodeficiency | 72.18 | 9.41 | 160 | 176782 | 14668 | 50413514 |
Muscle twitching | 71.20 | 9.41 | 163 | 176779 | 15268 | 50412914 |
Loss of consciousness | 69.56 | 9.41 | 612 | 176330 | 103741 | 50324441 |
Galactorrhoea | 69.37 | 9.41 | 75 | 176867 | 3648 | 50424534 |
Irritable bowel syndrome | 68.51 | 9.41 | 48 | 176894 | 51393 | 50376789 |
Muscle rigidity | 68.22 | 9.41 | 123 | 176819 | 9706 | 50418476 |
Exposure via ingestion | 67.79 | 9.41 | 65 | 176877 | 2738 | 50425444 |
Small for dates baby | 67.76 | 9.41 | 72 | 176870 | 3433 | 50424749 |
Blister | 65.75 | 9.41 | 124 | 176818 | 85294 | 50342888 |
Alcoholism | 64.56 | 9.41 | 50 | 176892 | 1570 | 50426612 |
Intentional product use issue | 64.33 | 9.41 | 106 | 176836 | 76812 | 50351370 |
Memory impairment | 63.42 | 9.41 | 485 | 176457 | 78875 | 50349307 |
Extrapyramidal disorder | 61.86 | 9.41 | 131 | 176811 | 11639 | 50416543 |
Dyskinesia | 60.81 | 9.41 | 225 | 176717 | 27636 | 50400546 |
Self-injurious ideation | 60.27 | 9.41 | 55 | 176887 | 2174 | 50426008 |
Stomatitis | 59.58 | 9.41 | 170 | 176772 | 101174 | 50327008 |
Ill-defined disorder | 59.36 | 9.41 | 62 | 176880 | 54592 | 50373590 |
Mania | 56.80 | 9.41 | 121 | 176821 | 10795 | 50417387 |
Interstitial lung disease | 55.88 | 9.41 | 62 | 176880 | 53114 | 50375068 |
Hallucination | 54.81 | 9.41 | 314 | 176628 | 46343 | 50381839 |
Depressed mood | 54.68 | 9.41 | 250 | 176692 | 33773 | 50394409 |
Arthralgia | 54.53 | 9.41 | 1145 | 175797 | 437557 | 49990625 |
Crying | 54.24 | 9.41 | 176 | 176766 | 20240 | 50407942 |
Malignant neoplasm progression | 54.11 | 9.41 | 97 | 176845 | 68027 | 50360155 |
Yawning | 53.71 | 9.41 | 36 | 176906 | 897 | 50427285 |
Disorientation | 53.55 | 9.41 | 256 | 176686 | 35228 | 50392954 |
Dizziness | 52.68 | 9.41 | 1584 | 175358 | 344785 | 50083397 |
C-reactive protein increased | 52.49 | 9.41 | 95 | 176847 | 66379 | 50361803 |
C-reactive protein abnormal | 52.38 | 9.41 | 16 | 176926 | 27793 | 50400389 |
Myocardial stunning | 52.21 | 9.41 | 20 | 176922 | 139 | 50428043 |
Hepatic enzyme increased | 52.09 | 9.41 | 275 | 176667 | 137105 | 50291077 |
Rash erythematous | 51.55 | 9.41 | 250 | 176692 | 34602 | 50393580 |
Obsessive-compulsive disorder | 51.53 | 9.41 | 61 | 176881 | 3279 | 50424903 |
Coma scale abnormal | 51.45 | 9.41 | 73 | 176869 | 4698 | 50423484 |
Haematemesis | 50.87 | 9.41 | 212 | 176730 | 27513 | 50400669 |
Psychomotor hyperactivity | 50.60 | 9.41 | 105 | 176837 | 9196 | 50418986 |
Neutropenia | 50.27 | 9.41 | 307 | 176635 | 147658 | 50280524 |
Inappropriate antidiuretic hormone secretion | 50.12 | 9.41 | 129 | 176813 | 13014 | 50415168 |
Pancytopenia | 50.10 | 9.41 | 140 | 176802 | 83890 | 50344292 |
Ventricular septal defect | 49.87 | 9.41 | 66 | 176876 | 3975 | 50424207 |
Intentional product misuse | 49.43 | 9.41 | 306 | 176636 | 46428 | 50381754 |
Bradycardia | 49.40 | 9.41 | 390 | 176552 | 64036 | 50364146 |
Bursitis | 48.51 | 9.41 | 179 | 176763 | 21956 | 50406226 |
Pain | 48.43 | 9.41 | 1600 | 175342 | 577303 | 49850879 |
Pneumonia | 48.06 | 9.41 | 984 | 175958 | 377417 | 50050765 |
Hyperreflexia | 47.54 | 9.41 | 73 | 176869 | 5045 | 50423137 |
Psychotic disorder | 47.48 | 9.41 | 176 | 176766 | 21636 | 50406546 |
Product prescribing error | 47.19 | 9.41 | 171 | 176771 | 20790 | 50407392 |
Parkinsonism | 47.11 | 9.41 | 99 | 176843 | 8748 | 50419434 |
Medication error | 47.10 | 9.41 | 250 | 176692 | 35854 | 50392328 |
Accidental death | 45.15 | 9.41 | 42 | 176900 | 1702 | 50426480 |
Rheumatic fever | 44.22 | 9.41 | 4 | 176938 | 16863 | 50411319 |
Depressed level of consciousness | 44.04 | 9.41 | 322 | 176620 | 51631 | 50376551 |
Nasopharyngitis | 43.36 | 9.41 | 448 | 176494 | 192479 | 50235703 |
Loss of libido | 42.86 | 9.41 | 35 | 176907 | 1188 | 50426994 |
Atrial septal defect | 42.30 | 9.41 | 78 | 176864 | 6263 | 50421919 |
Lethargy | 42.26 | 9.41 | 307 | 176635 | 49125 | 50379057 |
Generalised tonic-clonic seizure | 42.03 | 9.41 | 193 | 176749 | 26117 | 50402065 |
Pulseless electrical activity | 41.73 | 9.41 | 81 | 176861 | 6760 | 50421422 |
Illness anxiety disorder | 41.31 | 9.41 | 16 | 176926 | 115 | 50428067 |
Drug dependence | 40.99 | 9.41 | 157 | 176785 | 19602 | 50408580 |
Cerebral vasoconstriction | 40.37 | 9.41 | 31 | 176911 | 961 | 50427221 |
Alcohol abuse | 40.25 | 9.41 | 41 | 176901 | 1860 | 50426322 |
Anger | 39.93 | 9.41 | 108 | 176834 | 11225 | 50416957 |
Septic shock | 39.74 | 9.41 | 88 | 176854 | 57087 | 50371095 |
Thrombocytopenia | 39.74 | 9.41 | 272 | 176670 | 127401 | 50300781 |
Hip arthroplasty | 39.72 | 9.41 | 29 | 176913 | 30400 | 50397782 |
Respiratory disorder neonatal | 39.60 | 9.41 | 30 | 176912 | 911 | 50427271 |
Drug withdrawal syndrome neonatal | 39.51 | 9.41 | 40 | 176902 | 1801 | 50426381 |
Impulsive behaviour | 39.47 | 9.41 | 36 | 176906 | 1422 | 50426760 |
Mood swings | 39.23 | 9.41 | 134 | 176808 | 15820 | 50412362 |
Ventricular tachycardia | 39.01 | 9.41 | 133 | 176809 | 15688 | 50412494 |
Posturing | 38.84 | 9.41 | 23 | 176919 | 458 | 50427724 |
Antidepressant drug level above therapeutic | 38.14 | 9.41 | 21 | 176921 | 362 | 50427820 |
Bradyphrenia | 37.72 | 9.41 | 73 | 176869 | 6079 | 50422103 |
Product use in unapproved indication | 37.42 | 9.41 | 244 | 176698 | 115575 | 50312607 |
Disease progression | 37.40 | 9.41 | 190 | 176752 | 95676 | 50332506 |
Calcium deficiency | 37.16 | 9.41 | 29 | 176913 | 921 | 50427261 |
Catatonia | 37.13 | 9.41 | 55 | 176887 | 3681 | 50424501 |
Nicotine dependence | 37.05 | 9.41 | 25 | 176917 | 630 | 50427552 |
Hypokinesia | 36.78 | 9.41 | 110 | 176832 | 12107 | 50416075 |
Hepatic function abnormal | 36.71 | 9.41 | 36 | 176906 | 32645 | 50395537 |
Libido decreased | 36.00 | 9.41 | 43 | 176899 | 2333 | 50425849 |
Therapeutic product effect incomplete | 35.91 | 9.41 | 181 | 176761 | 91334 | 50336848 |
Thinking abnormal | 35.56 | 9.41 | 93 | 176849 | 9474 | 50418708 |
Red blood cell sedimentation rate abnormal | 35.45 | 9.41 | 7 | 176935 | 16336 | 50411846 |
Hypersensitivity | 35.42 | 9.41 | 534 | 176408 | 214627 | 50213555 |
Mucosal inflammation | 34.80 | 9.41 | 54 | 176888 | 40088 | 50388094 |
Syncope | 34.62 | 9.41 | 529 | 176413 | 102473 | 50325709 |
Angle closure glaucoma | 34.49 | 9.41 | 39 | 176903 | 1995 | 50426187 |
Cytomegalovirus infection | 34.44 | 9.41 | 10 | 176932 | 17952 | 50410230 |
Injection site pain | 34.31 | 9.41 | 237 | 176705 | 110787 | 50317395 |
Abnormal behaviour | 34.26 | 9.41 | 148 | 176794 | 19510 | 50408672 |
Knee arthroplasty | 34.26 | 9.41 | 45 | 176897 | 35801 | 50392381 |
Congenital thrombocytopenia | 33.71 | 9.41 | 11 | 176931 | 44 | 50428138 |
Abnormal dreams | 33.68 | 9.41 | 90 | 176852 | 9287 | 50418895 |
Suicidal behaviour | 33.35 | 9.41 | 41 | 176901 | 2293 | 50425889 |
Ductus arteriosus premature closure | 32.81 | 9.41 | 18 | 176924 | 308 | 50427874 |
Panic reaction | 31.88 | 9.41 | 50 | 176892 | 3519 | 50424663 |
Carcinoid heart disease | 31.79 | 9.41 | 9 | 176933 | 19 | 50428163 |
Apathy | 30.78 | 9.41 | 76 | 176866 | 7472 | 50420710 |
Liver disorder | 30.46 | 9.41 | 52 | 176890 | 37170 | 50391012 |
Rabbit syndrome | 30.38 | 9.41 | 17 | 176925 | 303 | 50427879 |
Platelet count decreased | 30.16 | 9.41 | 217 | 176725 | 100509 | 50327673 |
Alcohol use | 30.06 | 9.41 | 36 | 176906 | 1959 | 50426223 |
Hostility | 29.93 | 9.41 | 34 | 176908 | 1748 | 50426434 |
Hyperprolactinaemia | 29.86 | 9.41 | 47 | 176895 | 3318 | 50424864 |
Stiff person syndrome | 29.63 | 9.41 | 15 | 176927 | 216 | 50427966 |
Insomnia | 29.35 | 9.41 | 810 | 176132 | 174055 | 50254127 |
Rheumatoid arthritis | 29.25 | 9.41 | 515 | 176427 | 202035 | 50226147 |
COVID-19 | 29.12 | 9.41 | 76 | 176866 | 46586 | 50381596 |
Hallucination, auditory | 28.96 | 9.41 | 93 | 176849 | 10635 | 50417547 |
Disturbance in sexual arousal | 28.90 | 9.41 | 11 | 176931 | 75 | 50428107 |
Hypochloraemia | 28.64 | 9.41 | 32 | 176910 | 1615 | 50426567 |
Dyspnoea | 28.43 | 9.41 | 1596 | 175346 | 546012 | 49882170 |
Pneumocystis jirovecii pneumonia | 28.41 | 9.41 | 8 | 176934 | 14655 | 50413527 |
Female sexual arousal disorder | 28.30 | 9.41 | 7 | 176935 | 6 | 50428176 |
Psoriatic arthropathy | 28.29 | 9.41 | 78 | 176864 | 46954 | 50381228 |
Brain injury | 28.27 | 9.41 | 64 | 176878 | 5950 | 50422232 |
Tearfulness | 28.00 | 9.41 | 48 | 176894 | 3639 | 50424543 |
Arthritis | 27.85 | 9.41 | 183 | 176759 | 86538 | 50341644 |
Physical assault | 27.72 | 9.41 | 24 | 176918 | 884 | 50427298 |
Hypoglycaemia | 27.69 | 9.41 | 298 | 176644 | 53283 | 50374899 |
Drug eruption | 27.69 | 9.41 | 25 | 176917 | 23581 | 50404601 |
Drug resistance | 27.63 | 9.41 | 16 | 176926 | 18973 | 50409209 |
Dissociation | 27.63 | 9.41 | 37 | 176905 | 2254 | 50425928 |
Selective eating disorder | 27.51 | 9.41 | 33 | 176909 | 1799 | 50426383 |
Dystonia | 27.45 | 9.41 | 98 | 176844 | 11828 | 50416354 |
Paranoia | 27.30 | 9.41 | 89 | 176853 | 10259 | 50417923 |
Injection site erythema | 27.28 | 9.41 | 152 | 176790 | 74784 | 50353398 |
Bradykinesia | 26.93 | 9.41 | 49 | 176893 | 3894 | 50424288 |
Hyperkinesia | 26.61 | 9.41 | 29 | 176913 | 1423 | 50426759 |
Toxicologic test abnormal | 26.52 | 9.41 | 20 | 176922 | 603 | 50427579 |
Palmar-plantar erythrodysaesthesia syndrome | 26.43 | 9.41 | 19 | 176923 | 20079 | 50408103 |
Tenosynovitis | 26.41 | 9.41 | 3 | 176939 | 10562 | 50417620 |
Alcohol poisoning | 26.33 | 9.41 | 32 | 176910 | 1768 | 50426414 |
Congenital pulmonary valve atresia | 26.29 | 9.41 | 10 | 176932 | 68 | 50428114 |
Cholecystitis chronic | 26.27 | 9.41 | 84 | 176858 | 9585 | 50418597 |
Leukopenia | 26.24 | 9.41 | 134 | 176808 | 67394 | 50360788 |
Emotional distress | 26.23 | 9.41 | 181 | 176761 | 28482 | 50399700 |
Amnesia | 26.17 | 9.41 | 244 | 176698 | 42016 | 50386166 |
Homicidal ideation | 26.12 | 9.41 | 31 | 176911 | 1671 | 50426511 |
Post viral fatigue syndrome | 25.86 | 9.41 | 15 | 176927 | 287 | 50427895 |
Macular degeneration | 25.82 | 9.41 | 9 | 176933 | 14379 | 50413803 |
Injection site reaction | 25.81 | 9.41 | 89 | 176853 | 49943 | 50378239 |
Skin ulcer | 25.67 | 9.41 | 53 | 176889 | 35265 | 50392917 |
Major depression | 25.67 | 9.41 | 67 | 176875 | 6817 | 50421365 |
Flat affect | 25.57 | 9.41 | 27 | 176915 | 1278 | 50426904 |
Premature delivery | 25.51 | 9.41 | 27 | 176915 | 23636 | 50404546 |
Obsessive thoughts | 25.43 | 9.41 | 18 | 176924 | 491 | 50427691 |
Optic ischaemic neuropathy | 25.38 | 9.41 | 24 | 176918 | 993 | 50427189 |
Ventricular fibrillation | 25.36 | 9.41 | 88 | 176854 | 10471 | 50417711 |
Hypocoagulable state | 25.12 | 9.41 | 23 | 176919 | 913 | 50427269 |
Product dose omission issue | 25.10 | 9.41 | 472 | 176470 | 183366 | 50244816 |
Bone marrow failure | 25.07 | 9.41 | 36 | 176906 | 27588 | 50400594 |
Myelosuppression | 25.06 | 9.41 | 8 | 176934 | 13509 | 50414673 |
Histrionic personality disorder | 25.04 | 9.41 | 9 | 176933 | 51 | 50428131 |
Ventricular arrhythmia | 25.02 | 9.41 | 43 | 176899 | 3266 | 50424916 |
Maternal drugs affecting foetus | 24.95 | 9.41 | 55 | 176887 | 5022 | 50423160 |
Rheumatoid nodule | 24.58 | 9.41 | 7 | 176935 | 12728 | 50415454 |
Sputum purulent | 24.56 | 9.41 | 23 | 176919 | 940 | 50427242 |
Mutism | 24.30 | 9.41 | 27 | 176915 | 1354 | 50426828 |
Cardiac failure congestive | 24.20 | 9.41 | 184 | 176758 | 84198 | 50343984 |
Secondary immunodeficiency | 24.03 | 9.41 | 25 | 176917 | 1163 | 50427019 |
Cystoid macular oedema | 24.02 | 9.41 | 27 | 176915 | 1372 | 50426810 |
Lower respiratory tract infection | 23.93 | 9.41 | 215 | 176727 | 94986 | 50333196 |
Epilepsy | 23.93 | 9.41 | 143 | 176799 | 21424 | 50406758 |
Mental disorder | 23.88 | 9.41 | 145 | 176797 | 21846 | 50406336 |
Cataract | 23.83 | 9.41 | 85 | 176857 | 47215 | 50380967 |
Pupillary reflex impaired | 23.64 | 9.41 | 31 | 176911 | 1850 | 50426332 |
Speech disorder | 23.41 | 9.41 | 208 | 176734 | 35340 | 50392842 |
Delirium | 23.39 | 9.41 | 220 | 176722 | 37972 | 50390210 |
Condition aggravated | 23.33 | 9.41 | 827 | 176115 | 296231 | 50131951 |
Foetal chromosome abnormality | 23.24 | 9.41 | 7 | 176935 | 20 | 50428162 |
Personality change | 23.19 | 9.41 | 57 | 176885 | 5588 | 50422594 |
Photosensitivity reaction | 23.11 | 9.41 | 98 | 176844 | 12813 | 50415369 |
Blood cholesterol increased | 22.93 | 9.41 | 107 | 176835 | 55108 | 50373074 |
Restless legs syndrome | 22.77 | 9.41 | 113 | 176829 | 15784 | 50412398 |
Dermatillomania | 22.66 | 9.41 | 11 | 176931 | 144 | 50428038 |
Infantile apnoea | 22.55 | 9.41 | 21 | 176921 | 852 | 50427330 |
Drug hypersensitivity | 22.50 | 9.41 | 687 | 176255 | 250323 | 50177859 |
Hypotonia | 22.40 | 9.41 | 71 | 176871 | 8063 | 50420119 |
Concussion | 22.32 | 9.41 | 68 | 176874 | 7560 | 50420622 |
Bipolar I disorder | 22.23 | 9.41 | 27 | 176915 | 1491 | 50426691 |
Adrenal insufficiency | 22.19 | 9.41 | 11 | 176931 | 14232 | 50413950 |
Goitre | 22.16 | 9.41 | 54 | 176888 | 5266 | 50422916 |
Pruritus | 22.14 | 9.41 | 790 | 176152 | 282778 | 50145404 |
Pregnancy | 22.09 | 9.41 | 178 | 176764 | 29399 | 50398783 |
Nervousness | 22.08 | 9.41 | 169 | 176773 | 27482 | 50400700 |
Hypotonia neonatal | 22.02 | 9.41 | 22 | 176920 | 975 | 50427207 |
Neuropathy peripheral | 21.99 | 9.41 | 224 | 176718 | 96533 | 50331649 |
Neuropathy, ataxia, retinitis pigmentosa syndrome | 21.88 | 9.41 | 8 | 176934 | 48 | 50428134 |
Potentiating drug interaction | 21.85 | 9.41 | 44 | 176898 | 3772 | 50424410 |
Asthma | 21.80 | 9.41 | 436 | 176506 | 88901 | 50339281 |
Cardiac failure | 21.71 | 9.41 | 166 | 176776 | 75874 | 50352308 |
Liver function test increased | 21.67 | 9.41 | 35 | 176907 | 25571 | 50402611 |
Pruritus allergic | 21.64 | 9.41 | 23 | 176919 | 1097 | 50427085 |
Acute myeloid leukaemia | 21.51 | 9.41 | 13 | 176929 | 15061 | 50413121 |
Rib deformity | 21.51 | 9.41 | 11 | 176931 | 162 | 50428020 |
Hospitalisation | 21.49 | 9.41 | 144 | 176798 | 67793 | 50360389 |
Sinus tachycardia | 21.44 | 9.41 | 138 | 176804 | 21216 | 50406966 |
Libido increased | 21.36 | 9.41 | 24 | 176918 | 1219 | 50426963 |
Tachyphrenia | 21.33 | 9.41 | 24 | 176918 | 1221 | 50426961 |
Postmortem blood drug level increased | 21.12 | 9.41 | 17 | 176925 | 565 | 50427617 |
Adrenergic syndrome | 21.07 | 9.41 | 7 | 176935 | 30 | 50428152 |
Coma | 21.01 | 9.41 | 297 | 176645 | 56582 | 50371600 |
Neoplasm progression | 20.99 | 9.41 | 44 | 176898 | 29113 | 50399069 |
Negative thoughts | 20.79 | 9.41 | 20 | 176922 | 846 | 50427336 |
Substance abuser | 20.78 | 9.41 | 6 | 176936 | 14 | 50428168 |
Fibromyalgia | 20.60 | 9.41 | 84 | 176858 | 44894 | 50383288 |
Localised infection | 20.49 | 9.41 | 36 | 176906 | 25449 | 50402733 |
Neonatal respiratory depression | 20.48 | 9.41 | 8 | 176934 | 59 | 50428123 |
Hypoxic-ischaemic encephalopathy | 20.46 | 9.41 | 43 | 176899 | 3799 | 50424383 |
Talipes | 20.46 | 9.41 | 25 | 176917 | 1389 | 50426793 |
Musculoskeletal stiffness | 20.39 | 9.41 | 321 | 176621 | 128160 | 50300022 |
Vascular access site infection | 20.20 | 9.41 | 7 | 176935 | 35 | 50428147 |
Gastrointestinal disorder | 20.12 | 9.41 | 222 | 176720 | 94234 | 50333948 |
Aspartate aminotransferase increased | 20.11 | 9.41 | 175 | 176767 | 77823 | 50350359 |
Vascular access site thrombosis | 20.04 | 9.41 | 7 | 176935 | 36 | 50428146 |
Diaphragmatic rupture | 19.92 | 9.41 | 12 | 176930 | 247 | 50427935 |
Antidepressant drug level increased | 19.83 | 9.41 | 12 | 176930 | 249 | 50427933 |
Pulmonary valve stenosis congenital | 19.82 | 9.41 | 10 | 176932 | 143 | 50428039 |
Urticaria | 19.80 | 9.41 | 326 | 176616 | 129235 | 50298947 |
Injection site swelling | 19.78 | 9.41 | 77 | 176865 | 41696 | 50386486 |
Hallucination, visual | 19.73 | 9.41 | 112 | 176830 | 16470 | 50411712 |
Drug tolerance decreased | 19.71 | 9.41 | 4 | 176938 | 9156 | 50419026 |
Activation syndrome | 19.56 | 9.41 | 11 | 176931 | 198 | 50427984 |
Product substitution issue | 19.48 | 9.41 | 99 | 176843 | 13958 | 50414224 |
Hypertonia | 19.48 | 9.41 | 43 | 176899 | 3930 | 50424252 |
Neonatal hypoxia | 19.45 | 9.41 | 15 | 176927 | 468 | 50427714 |
Iris coloboma | 19.43 | 9.41 | 7 | 176935 | 40 | 50428142 |
Basal ganglion degeneration | 19.40 | 9.41 | 14 | 176928 | 394 | 50427788 |
Self esteem decreased | 19.35 | 9.41 | 16 | 176926 | 553 | 50427629 |
Cognitive disorder | 19.04 | 9.41 | 237 | 176705 | 43886 | 50384296 |
Dementia | 19.00 | 9.41 | 108 | 176834 | 15889 | 50412293 |
Bronchomalacia | 18.94 | 9.41 | 11 | 176931 | 211 | 50427971 |
Post-traumatic neck syndrome | 18.81 | 9.41 | 28 | 176914 | 1882 | 50426300 |
Facial paralysis | 18.65 | 9.41 | 91 | 176851 | 12624 | 50415558 |
Sexual inhibition | 18.64 | 9.41 | 4 | 176938 | 0 | 50428182 |
Acquired epileptic aphasia | 18.64 | 9.41 | 4 | 176938 | 0 | 50428182 |
Osmotic demyelination syndrome | 18.61 | 9.41 | 16 | 176926 | 584 | 50427598 |
Agonal rhythm | 18.58 | 9.41 | 6 | 176936 | 23 | 50428159 |
Dysarthria | 18.39 | 9.41 | 206 | 176736 | 37197 | 50390985 |
CYP3A4 polymorphism | 18.37 | 9.41 | 8 | 176934 | 80 | 50428102 |
Chronic spontaneous urticaria | 18.37 | 9.41 | 15 | 176927 | 509 | 50427673 |
Abnormal weight gain | 18.36 | 9.41 | 24 | 176918 | 1428 | 50426754 |
Orgasm abnormal | 18.29 | 9.41 | 8 | 176934 | 81 | 50428101 |
Cerebrospinal fluid retention | 18.29 | 9.41 | 8 | 176934 | 81 | 50428101 |
Atonic urinary bladder | 18.20 | 9.41 | 8 | 176934 | 82 | 50428100 |
Urinary retention | 18.16 | 9.41 | 155 | 176787 | 26035 | 50402147 |
Acute kidney injury | 18.10 | 9.41 | 634 | 176308 | 227424 | 50200758 |
Infected dermal cyst | 18.07 | 9.41 | 14 | 176928 | 440 | 50427742 |
Haematotoxicity | 17.95 | 9.41 | 3 | 176939 | 7892 | 50420290 |
Caput succedaneum | 17.84 | 9.41 | 5 | 176937 | 10 | 50428172 |
Fear | 17.79 | 9.41 | 99 | 176843 | 14450 | 50413732 |
CFTR gene mutation | 17.79 | 9.41 | 8 | 176934 | 87 | 50428095 |
Gestational diabetes | 17.74 | 9.41 | 62 | 176880 | 7403 | 50420779 |
Alcohol interaction | 17.73 | 9.41 | 29 | 176913 | 2115 | 50426067 |
Meconium in amniotic fluid | 17.73 | 9.41 | 11 | 176931 | 239 | 50427943 |
Herpes zoster | 17.73 | 9.41 | 160 | 176782 | 70626 | 50357556 |
Head injury | 17.64 | 9.41 | 144 | 176798 | 23876 | 50404306 |
Panic disorder | 17.51 | 9.41 | 30 | 176912 | 2273 | 50425909 |
Bipolar II disorder | 17.34 | 9.41 | 11 | 176931 | 249 | 50427933 |
Transplant rejection | 17.26 | 9.41 | 6 | 176936 | 9603 | 50418579 |
Amputation stump pain | 17.15 | 9.41 | 6 | 176936 | 31 | 50428151 |
Alanine aminotransferase increased | 17.14 | 9.41 | 212 | 176730 | 88147 | 50340035 |
Areflexia | 17.06 | 9.41 | 33 | 176909 | 2747 | 50425435 |
Mood altered | 17.04 | 9.41 | 89 | 176853 | 12684 | 50415498 |
Non-cardiogenic pulmonary oedema | 17.02 | 9.41 | 15 | 176927 | 566 | 50427616 |
Retinal coloboma | 16.99 | 9.41 | 6 | 176936 | 32 | 50428150 |
Clonus | 16.99 | 9.41 | 42 | 176900 | 4133 | 50424049 |
Injection site pruritus | 16.97 | 9.41 | 78 | 176864 | 40333 | 50387849 |
Anaemia | 16.92 | 9.41 | 716 | 176226 | 251740 | 50176442 |
Social avoidant behaviour | 16.92 | 9.41 | 33 | 176909 | 2764 | 50425418 |
Meningitis streptococcal | 16.89 | 9.41 | 9 | 176933 | 145 | 50428037 |
Lipoedema | 16.84 | 9.41 | 11 | 176931 | 262 | 50427920 |
Cardiac steatosis | 16.84 | 9.41 | 6 | 176936 | 33 | 50428149 |
Metastases to bone | 16.78 | 9.41 | 23 | 176919 | 17972 | 50410210 |
Labelled drug-drug interaction issue | 16.77 | 9.41 | 11 | 176931 | 264 | 50427918 |
Social problem | 16.66 | 9.41 | 17 | 176925 | 773 | 50427409 |
Periventricular leukomalacia | 16.62 | 9.41 | 7 | 176935 | 64 | 50428118 |
Hypokalaemia | 16.59 | 9.41 | 414 | 176528 | 87578 | 50340604 |
Metastases to liver | 16.53 | 9.41 | 28 | 176914 | 20076 | 50408106 |
Sternal fracture | 16.45 | 9.41 | 27 | 176915 | 1975 | 50426207 |
Respiratory disorder | 16.41 | 9.41 | 55 | 176887 | 31132 | 50397050 |
Pleural effusion | 16.34 | 9.41 | 194 | 176748 | 81260 | 50346922 |
Polyhydramnios | 16.22 | 9.41 | 27 | 176915 | 1998 | 50426184 |
Renal impairment | 16.04 | 9.41 | 178 | 176764 | 75483 | 50352699 |
Depression suicidal | 15.91 | 9.41 | 23 | 176919 | 1506 | 50426676 |
Morbid thoughts | 15.89 | 9.41 | 14 | 176928 | 528 | 50427654 |
Kinematic imbalances due to suboccipital strain | 15.88 | 9.41 | 4 | 176938 | 4 | 50428178 |
Panniculitis | 15.82 | 9.41 | 5 | 176937 | 8498 | 50419684 |
Decerebrate posture | 15.82 | 9.41 | 8 | 176934 | 115 | 50428067 |
Multiple organ dysfunction syndrome | 15.77 | 9.41 | 107 | 176835 | 50230 | 50377952 |
Multiple sclerosis relapse | 15.73 | 9.41 | 224 | 176718 | 42740 | 50385442 |
Rhabdomyolysis | 15.73 | 9.41 | 207 | 176735 | 38820 | 50389362 |
Dry mouth | 15.71 | 9.41 | 280 | 176662 | 55898 | 50372284 |
Tissue infiltration | 15.65 | 9.41 | 14 | 176928 | 539 | 50427643 |
Antisocial behaviour | 15.64 | 9.41 | 11 | 176931 | 297 | 50427885 |
Pulmonary valve disease | 15.52 | 9.41 | 5 | 176937 | 19 | 50428163 |
Product administration error | 15.50 | 9.41 | 120 | 176822 | 19579 | 50408603 |
Hippocampal sclerosis | 15.41 | 9.41 | 7 | 176935 | 78 | 50428104 |
Hypersomnia | 15.40 | 9.41 | 99 | 176843 | 15215 | 50412967 |
Polymenorrhagia | 15.39 | 9.41 | 6 | 176936 | 44 | 50428138 |
Orthostatic intolerance | 15.32 | 9.41 | 18 | 176924 | 960 | 50427222 |
Hypertonic bladder | 15.31 | 9.41 | 33 | 176909 | 2967 | 50425215 |
Urethral haemorrhage | 15.27 | 9.41 | 6 | 176936 | 45 | 50428137 |
Respiratory tract infection | 15.17 | 9.41 | 59 | 176883 | 31958 | 50396224 |
Melaena | 15.10 | 9.41 | 152 | 176790 | 26712 | 50401470 |
Fluid retention | 15.08 | 9.41 | 255 | 176687 | 50394 | 50377788 |
Mobility decreased | 15.06 | 9.41 | 193 | 176749 | 79755 | 50348427 |
Prescribed overdose | 15.06 | 9.41 | 95 | 176847 | 14505 | 50413677 |
Skin swelling | 15.02 | 9.41 | 27 | 176915 | 2125 | 50426057 |
Hyporeflexia | 15.02 | 9.41 | 24 | 176918 | 1716 | 50426466 |
Therapeutic response decreased | 14.99 | 9.41 | 100 | 176842 | 47131 | 50381051 |
Soft tissue injury | 14.97 | 9.41 | 22 | 176920 | 1462 | 50426720 |
Vertigo CNS origin | 14.94 | 9.41 | 5 | 176937 | 22 | 50428160 |
Sedation complication | 14.87 | 9.41 | 6 | 176936 | 8760 | 50419422 |
Borderline personality disorder | 14.86 | 9.41 | 15 | 176927 | 673 | 50427509 |
Obesity | 14.80 | 9.41 | 105 | 176837 | 16670 | 50411512 |
Akinesia | 14.80 | 9.41 | 22 | 176920 | 1477 | 50426705 |
Therapy non-responder | 14.74 | 9.41 | 111 | 176831 | 50911 | 50377271 |
Osteonecrosis of jaw | 14.74 | 9.41 | 61 | 176881 | 32465 | 50395717 |
Female orgasmic disorder | 14.73 | 9.41 | 6 | 176936 | 50 | 50428132 |
Pneumonia viral | 14.67 | 9.41 | 3 | 176939 | 6831 | 50421351 |
Dysponesis | 14.62 | 9.41 | 4 | 176938 | 7 | 50428175 |
Dysaesthesia | 14.59 | 9.41 | 37 | 176905 | 3698 | 50424484 |
Blood bilirubin increased | 14.57 | 9.41 | 60 | 176882 | 31978 | 50396204 |
Cytokine release syndrome | 14.50 | 9.41 | 6 | 176936 | 8628 | 50419554 |
Neuroleptic malignant syndrome | 14.47 | 9.41 | 77 | 176865 | 11053 | 50417129 |
Amniorrhexis | 14.43 | 9.41 | 5 | 176937 | 25 | 50428157 |
Polydipsia | 14.41 | 9.41 | 33 | 176909 | 3091 | 50425091 |
Respiratory alkalosis | 14.37 | 9.41 | 29 | 176913 | 2490 | 50425692 |
Hallucinations, mixed | 14.35 | 9.41 | 39 | 176903 | 4064 | 50424118 |
Neutrophil count decreased | 14.33 | 9.41 | 98 | 176844 | 45928 | 50382254 |
Dissociative amnesia | 14.27 | 9.41 | 5 | 176937 | 26 | 50428156 |
Pupil fixed | 14.22 | 9.41 | 22 | 176920 | 1530 | 50426652 |
Urine abnormality | 14.13 | 9.41 | 51 | 176891 | 6187 | 50421995 |
Aspiration | 14.09 | 9.41 | 67 | 176875 | 9197 | 50418985 |
Uterine enlargement | 14.07 | 9.41 | 18 | 176924 | 1048 | 50427134 |
Red blood cell sedimentation rate increased | 14.07 | 9.41 | 54 | 176888 | 29362 | 50398820 |
Accidental exposure to product | 14.04 | 9.41 | 38 | 176904 | 23019 | 50405163 |
Vertigo | 14.02 | 9.41 | 257 | 176685 | 51575 | 50376607 |
Accommodation disorder | 13.97 | 9.41 | 11 | 176931 | 354 | 50427828 |
Muscle tightness | 13.97 | 9.41 | 72 | 176870 | 10208 | 50417974 |
Increased appetite | 13.85 | 9.41 | 62 | 176880 | 8299 | 50419883 |
Reflexes abnormal | 13.83 | 9.41 | 13 | 176929 | 534 | 50427648 |
Miosis | 13.80 | 9.41 | 51 | 176891 | 6259 | 50421923 |
Tic | 13.69 | 9.41 | 19 | 176923 | 1198 | 50426984 |
Circulatory collapse | 13.67 | 9.41 | 118 | 176824 | 19882 | 50408300 |
Hepatotoxicity | 13.66 | 9.41 | 49 | 176893 | 27177 | 50401005 |
Drug dose titration not performed | 13.64 | 9.41 | 12 | 176930 | 452 | 50427730 |
Tardive dyskinesia | 13.62 | 9.41 | 56 | 176886 | 7223 | 50420959 |
Ureteric dilatation | 13.54 | 9.41 | 5 | 176937 | 31 | 50428151 |
Constipation | 13.52 | 9.41 | 786 | 176156 | 184922 | 50243260 |
Ocular hyperaemia | 13.48 | 9.41 | 32 | 176910 | 20260 | 50407922 |
Thrombotic microangiopathy | 13.38 | 9.41 | 7 | 176935 | 8784 | 50419398 |
Feeling abnormal | 13.30 | 9.41 | 551 | 176391 | 124941 | 50303241 |
Trisomy 18 | 13.27 | 9.41 | 5 | 176937 | 33 | 50428149 |
Balance disorder | 13.27 | 9.41 | 332 | 176610 | 70258 | 50357924 |
Substance abuse | 13.24 | 9.41 | 38 | 176904 | 4086 | 50424096 |
Cholecystectomy | 13.23 | 9.41 | 66 | 176876 | 9237 | 50418945 |
Blood creatinine increased | 13.21 | 9.41 | 187 | 176755 | 75973 | 50352209 |
Bronchopulmonary aspergillosis | 13.20 | 9.41 | 5 | 176937 | 7587 | 50420595 |
Blood ethanol increased | 13.18 | 9.41 | 7 | 176935 | 112 | 50428070 |
Indifference | 13.18 | 9.41 | 7 | 176935 | 112 | 50428070 |
Activated partial thromboplastin time abnormal | 13.12 | 9.41 | 7 | 176935 | 113 | 50428069 |
Hypercalcaemia | 13.11 | 9.41 | 40 | 176902 | 23312 | 50404870 |
Delusion | 12.98 | 9.41 | 72 | 176870 | 10497 | 50417685 |
Pneumonitis | 12.96 | 9.41 | 56 | 176886 | 29454 | 50398728 |
Hypervigilance | 12.91 | 9.41 | 10 | 176932 | 314 | 50427868 |
Throat irritation | 12.91 | 9.41 | 58 | 176884 | 30181 | 50398001 |
Trismus | 12.91 | 9.41 | 33 | 176909 | 3315 | 50424867 |
Visual field defect | 12.88 | 9.41 | 47 | 176895 | 5732 | 50422450 |
Surgery | 12.86 | 9.41 | 58 | 176884 | 30147 | 50398035 |
Sensory disturbance | 12.85 | 9.41 | 78 | 176864 | 11751 | 50416431 |
Disinhibition | 12.84 | 9.41 | 15 | 176927 | 795 | 50427387 |
Sleep disorder | 12.80 | 9.41 | 276 | 176666 | 57007 | 50371175 |
Peritoneal perforation | 12.80 | 9.41 | 7 | 176935 | 119 | 50428063 |
Atrial fibrillation | 12.73 | 9.41 | 265 | 176677 | 101480 | 50326702 |
Regressive behaviour | 12.67 | 9.41 | 6 | 176936 | 74 | 50428108 |
Post procedural haematuria | 12.67 | 9.41 | 5 | 176937 | 38 | 50428144 |
Incoherent | 12.65 | 9.41 | 38 | 176904 | 4192 | 50423990 |
Labelled drug-drug interaction medication error | 12.62 | 9.41 | 71 | 176871 | 10406 | 50417776 |
Injection site bruising | 12.62 | 9.41 | 76 | 176866 | 36692 | 50391490 |
Tension | 12.55 | 9.41 | 29 | 176913 | 2733 | 50425449 |
Merycism | 12.53 | 9.41 | 8 | 176934 | 183 | 50427999 |
Neutrophil count abnormal | 12.50 | 9.41 | 27 | 176915 | 2432 | 50425750 |
Toxic epidermal necrolysis | 12.48 | 9.41 | 35 | 176907 | 20957 | 50407225 |
Ejection fraction decreased | 12.46 | 9.41 | 29 | 176913 | 18491 | 50409691 |
Pleurisy | 12.46 | 9.41 | 5 | 176937 | 7326 | 50420856 |
Periodic limb movement disorder | 12.46 | 9.41 | 8 | 176934 | 185 | 50427997 |
Fear of injection | 12.45 | 9.41 | 3 | 176939 | 6100 | 50422082 |
Exposure to allergen | 12.42 | 9.41 | 8 | 176934 | 186 | 50427996 |
Blood creatine phosphokinase increased | 12.41 | 9.41 | 144 | 176798 | 26223 | 50401959 |
Conversion disorder | 12.41 | 9.41 | 21 | 176921 | 1575 | 50426607 |
Bradycardia neonatal | 12.31 | 9.41 | 15 | 176927 | 831 | 50427351 |
Paraesthesia | 12.30 | 9.41 | 526 | 176416 | 119717 | 50308465 |
Pseudomonas infection | 12.29 | 9.41 | 9 | 176933 | 9421 | 50418761 |
Right ventricular failure | 12.28 | 9.41 | 23 | 176919 | 15870 | 50412312 |
Stress | 12.28 | 9.41 | 260 | 176682 | 53533 | 50374649 |
Impaired self-care | 12.26 | 9.41 | 22 | 176920 | 1729 | 50426453 |
Mental impairment | 12.19 | 9.41 | 78 | 176864 | 11966 | 50416216 |
Cerebral ventricular rupture | 12.05 | 9.41 | 8 | 176934 | 196 | 50427986 |
Hyponatraemic syndrome | 12.01 | 9.41 | 12 | 176930 | 532 | 50427650 |
Pulmonary arterial hypertension | 11.99 | 9.41 | 34 | 176908 | 20285 | 50407897 |
Anaesthesia | 11.98 | 9.41 | 10 | 176932 | 350 | 50427832 |
Tachycardia | 11.97 | 9.41 | 444 | 176498 | 99319 | 50328863 |
Cervix haematoma uterine | 11.91 | 9.41 | 3 | 176939 | 3 | 50428179 |
Anti-neuronal antibody positive | 11.91 | 9.41 | 3 | 176939 | 3 | 50428179 |
Bisexuality | 11.91 | 9.41 | 3 | 176939 | 3 | 50428179 |
Onychogryphosis | 11.91 | 9.41 | 3 | 176939 | 3 | 50428179 |
Electrolyte substitution therapy | 11.91 | 9.41 | 3 | 176939 | 3 | 50428179 |
Neutrophil Pelger-Huet anomaly present | 11.88 | 9.41 | 6 | 176936 | 86 | 50428096 |
Joint ankylosis | 11.86 | 9.41 | 14 | 176928 | 750 | 50427432 |
Diarrhoea | 11.85 | 9.41 | 1842 | 175100 | 586634 | 49841548 |
Somatic symptom disorder | 11.83 | 9.41 | 23 | 176919 | 1921 | 50426261 |
White blood cell count decreased | 11.83 | 9.41 | 314 | 176628 | 116408 | 50311774 |
Poor quality sleep | 11.80 | 9.41 | 99 | 176843 | 16547 | 50411635 |
Hyperacusis | 11.79 | 9.41 | 22 | 176920 | 1782 | 50426400 |
Psychiatric symptom | 11.78 | 9.41 | 39 | 176903 | 4531 | 50423651 |
Initial insomnia | 11.74 | 9.41 | 42 | 176900 | 5073 | 50423109 |
Apgar score low | 11.62 | 9.41 | 13 | 176929 | 657 | 50427525 |
Renal disorder | 11.60 | 9.41 | 53 | 176889 | 27452 | 50400730 |
Pulmonary fibrosis | 11.60 | 9.41 | 45 | 176897 | 24392 | 50403790 |
Unevaluable event | 11.59 | 9.41 | 104 | 176838 | 45962 | 50382220 |
Microphthalmos | 11.49 | 9.41 | 7 | 176935 | 147 | 50428035 |
Bronchitis | 11.41 | 9.41 | 277 | 176665 | 103882 | 50324300 |
Pyelonephritis chronic | 11.41 | 9.41 | 8 | 176934 | 215 | 50427967 |
Congenital tricuspid valve incompetence | 11.29 | 9.41 | 6 | 176936 | 96 | 50428086 |
Vascular encephalopathy | 11.29 | 9.41 | 10 | 176932 | 380 | 50427802 |
Blunted affect | 11.25 | 9.41 | 8 | 176934 | 220 | 50427962 |
Personality disorder | 11.23 | 9.41 | 37 | 176905 | 4287 | 50423895 |
Menopause | 11.20 | 9.41 | 25 | 176917 | 2302 | 50425880 |
Differential white blood cell count abnormal | 11.17 | 9.41 | 13 | 176929 | 686 | 50427496 |
Tumour lysis syndrome | 11.16 | 9.41 | 6 | 176936 | 7415 | 50420767 |
Atrophic vulvovaginitis | 11.11 | 9.41 | 20 | 176922 | 1576 | 50426606 |
Dermatochalasis | 11.05 | 9.41 | 3 | 176939 | 5 | 50428177 |
Crepitations | 10.97 | 9.41 | 4 | 176938 | 6215 | 50421967 |
Marital problem | 10.97 | 9.41 | 7 | 176935 | 160 | 50428022 |
Hepatic steatosis | 10.96 | 9.41 | 132 | 176810 | 24252 | 50403930 |
Agitation neonatal | 10.93 | 9.41 | 11 | 176931 | 492 | 50427690 |
Joint range of motion decreased | 10.91 | 9.41 | 31 | 176911 | 18481 | 50409701 |
Sepsis | 10.88 | 9.41 | 368 | 176574 | 132557 | 50295625 |
Pulmonary valve incompetence | 10.84 | 9.41 | 17 | 176925 | 1196 | 50426986 |
Antipsychotic drug level above therapeutic | 10.83 | 9.41 | 15 | 176927 | 944 | 50427238 |
Blood pressure decreased | 10.82 | 9.41 | 264 | 176678 | 55645 | 50372537 |
Choanal atresia | 10.80 | 9.41 | 4 | 176938 | 25 | 50428157 |
Carcinoid syndrome | 10.77 | 9.41 | 6 | 176936 | 106 | 50428076 |
Biliary dyskinesia | 10.74 | 9.41 | 26 | 176916 | 2524 | 50425658 |
Device expulsion | 10.74 | 9.41 | 58 | 176884 | 28764 | 50399418 |
Congenital megacolon | 10.70 | 9.41 | 3 | 176939 | 6 | 50428176 |
No adverse event | 10.70 | 9.41 | 71 | 176871 | 33507 | 50394675 |
Drug reaction with eosinophilia and systemic symptoms | 10.70 | 9.41 | 57 | 176885 | 28367 | 50399815 |
Loss of bladder sensation | 10.67 | 9.41 | 4 | 176938 | 26 | 50428156 |
Sexually inappropriate behaviour | 10.67 | 9.41 | 6 | 176936 | 108 | 50428074 |
Sunburn | 10.66 | 9.41 | 25 | 176917 | 2378 | 50425804 |
Drug level above therapeutic | 10.60 | 9.41 | 34 | 176908 | 3886 | 50424296 |
Phobia | 10.59 | 9.41 | 9 | 176933 | 323 | 50427859 |
Mental status changes | 10.57 | 9.41 | 182 | 176760 | 36090 | 50392092 |
Hypocalcaemia | 10.53 | 9.41 | 53 | 176889 | 26763 | 50401419 |
Analgesic drug level above therapeutic | 10.53 | 9.41 | 7 | 176935 | 172 | 50428010 |
Sebaceous gland infection | 10.52 | 9.41 | 6 | 176936 | 111 | 50428071 |
Adverse event | 10.49 | 9.41 | 100 | 176842 | 43663 | 50384519 |
Unintentional medical device removal | 10.47 | 9.41 | 3 | 176939 | 5432 | 50422750 |
Maternal exposure during breast feeding | 10.47 | 9.41 | 30 | 176912 | 3224 | 50424958 |
Loss of personal independence in daily activities | 10.45 | 9.41 | 177 | 176765 | 69873 | 50358309 |
Thyroiditis | 10.42 | 9.41 | 21 | 176921 | 1801 | 50426381 |
Nodal arrhythmia | 10.39 | 9.41 | 16 | 176926 | 1108 | 50427074 |
Ascites | 10.37 | 9.41 | 78 | 176864 | 35783 | 50392399 |
Drug level increased | 10.34 | 9.41 | 108 | 176834 | 19160 | 50409022 |
Tuberculosis | 10.32 | 9.41 | 12 | 176930 | 10071 | 50418111 |
Oromandibular dystonia | 10.26 | 9.41 | 10 | 176932 | 430 | 50427752 |
Product administered to patient of inappropriate age | 10.22 | 9.41 | 26 | 176916 | 2604 | 50425578 |
Vaginal haemorrhage | 10.22 | 9.41 | 131 | 176811 | 24420 | 50403762 |
Systolic hypertension | 10.22 | 9.41 | 10 | 176932 | 432 | 50427750 |
Acidosis | 10.21 | 9.41 | 66 | 176876 | 10161 | 50418021 |
Aphasia | 10.21 | 9.41 | 148 | 176794 | 28346 | 50399836 |
Pancreatic injury | 10.18 | 9.41 | 4 | 176938 | 30 | 50428152 |
Body dysmorphic disorder | 10.17 | 9.41 | 8 | 176934 | 257 | 50427925 |
Pancreatitis | 10.07 | 9.41 | 207 | 176735 | 42407 | 50385775 |
Hip surgery | 10.04 | 9.41 | 26 | 176916 | 2632 | 50425550 |
Agoraphobia | 10.03 | 9.41 | 9 | 176933 | 348 | 50427834 |
Movement disorder | 10.02 | 9.41 | 100 | 176842 | 17532 | 50410650 |
Narcolepsy | 10.02 | 9.41 | 16 | 176926 | 1144 | 50427038 |
Drug abuser | 10.01 | 9.41 | 27 | 176915 | 2801 | 50425381 |
Hypersexuality | 9.99 | 9.41 | 10 | 176932 | 444 | 50427738 |
Psychogenic seizure | 9.95 | 9.41 | 19 | 176923 | 1566 | 50426616 |
Perinatal depression | 9.93 | 9.41 | 11 | 176931 | 550 | 50427632 |
Cleft lip and palate | 9.90 | 9.41 | 9 | 176933 | 354 | 50427828 |
Umbilical artery vascular resistance increased | 9.86 | 9.41 | 4 | 176938 | 33 | 50428149 |
Neonatal sinus tachycardia | 9.86 | 9.41 | 4 | 176938 | 33 | 50428149 |
Oral neoplasm benign | 9.85 | 9.41 | 3 | 176939 | 9 | 50428173 |
Tendonitis | 9.82 | 9.41 | 28 | 176914 | 16677 | 50411505 |
Nystagmus | 9.79 | 9.41 | 42 | 176900 | 5519 | 50422663 |
Hypertension | 9.75 | 9.41 | 622 | 176320 | 210581 | 50217601 |
Respiratory tract congestion | 9.74 | 9.41 | 22 | 176920 | 14177 | 50414005 |
Inner ear disorder | 9.74 | 9.41 | 10 | 176932 | 458 | 50427724 |
Drug screen positive | 9.65 | 9.41 | 30 | 176912 | 3372 | 50424810 |
Angiodermatitis | 9.64 | 9.41 | 5 | 176937 | 76 | 50428106 |
Hyperventilation | 9.64 | 9.41 | 41 | 176901 | 5368 | 50422814 |
Antisocial personality disorder | 9.61 | 9.41 | 3 | 176939 | 10 | 50428172 |
Neonatal infection | 9.57 | 9.41 | 6 | 176936 | 133 | 50428049 |
Vaginal discharge | 9.56 | 9.41 | 40 | 176902 | 5200 | 50422982 |
Posterior reversible encephalopathy syndrome | 9.55 | 9.41 | 24 | 176918 | 14904 | 50413278 |
Corneal reflex decreased | 9.53 | 9.41 | 6 | 176936 | 134 | 50428048 |
Cytopenia | 9.47 | 9.41 | 10 | 176932 | 8765 | 50419417 |
Myocardial fibrosis | 9.47 | 9.41 | 12 | 176930 | 692 | 50427490 |
Repetitive speech | 9.47 | 9.41 | 8 | 176934 | 285 | 50427897 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 959.82 | 10.64 | 1237 | 83816 | 89009 | 29400465 |
Toxicity to various agents | 806.30 | 10.64 | 1631 | 83422 | 172030 | 29317444 |
Serotonin syndrome | 492.47 | 10.64 | 406 | 84647 | 17106 | 29472368 |
Drug abuse | 474.47 | 10.64 | 835 | 84218 | 79048 | 29410426 |
Suicidal ideation | 335.70 | 10.64 | 455 | 84598 | 34261 | 29455213 |
Intentional overdose | 290.75 | 10.64 | 449 | 84604 | 38079 | 29451395 |
Overdose | 273.01 | 10.64 | 665 | 84388 | 79154 | 29410320 |
Suicide attempt | 227.76 | 10.64 | 376 | 84677 | 33734 | 29455740 |
Foetal exposure during pregnancy | 198.04 | 10.64 | 352 | 84701 | 33515 | 29455959 |
Drug interaction | 187.78 | 10.64 | 1086 | 83967 | 196299 | 29293175 |
Electrocardiogram QT prolonged | 160.17 | 10.64 | 334 | 84719 | 35803 | 29453671 |
Anxiety | 158.80 | 10.64 | 573 | 84480 | 84792 | 29404682 |
Disinhibition | 146.20 | 10.64 | 92 | 84961 | 2515 | 29486959 |
Intentional self-injury | 144.86 | 10.64 | 179 | 84874 | 12282 | 29477192 |
Respiratory disorder neonatal | 141.36 | 10.64 | 73 | 84980 | 1352 | 29488122 |
Obsessive-compulsive disorder | 141.05 | 10.64 | 112 | 84941 | 4464 | 29485010 |
Poisoning | 128.34 | 10.64 | 151 | 84902 | 9842 | 29479632 |
Antipsychotic drug level below therapeutic | 126.87 | 10.64 | 76 | 84977 | 1898 | 29487576 |
Paranoia | 126.44 | 10.64 | 149 | 84904 | 9728 | 29479746 |
Off label use | 118.72 | 10.64 | 455 | 84598 | 300345 | 29189129 |
Aggression | 117.99 | 10.64 | 293 | 84760 | 35248 | 29454226 |
Febrile neutropenia | 113.13 | 10.64 | 94 | 84959 | 112146 | 29377328 |
Pyrexia | 112.88 | 10.64 | 436 | 84617 | 287186 | 29202288 |
Psychotic disorder | 111.86 | 10.64 | 206 | 84847 | 20148 | 29469326 |
Agitation | 108.92 | 10.64 | 360 | 84693 | 50944 | 29438530 |
Drug withdrawal syndrome neonatal | 108.74 | 10.64 | 85 | 84968 | 3310 | 29486164 |
Agitation neonatal | 107.36 | 10.64 | 55 | 84998 | 1001 | 29488473 |
Restlessness | 106.77 | 10.64 | 212 | 84841 | 21933 | 29467541 |
Irritability | 106.72 | 10.64 | 212 | 84841 | 21940 | 29467534 |
Respiratory arrest | 105.49 | 10.64 | 231 | 84822 | 25602 | 29463872 |
Therapeutic product effect variable | 104.66 | 10.64 | 66 | 84987 | 1811 | 29487663 |
Neonatal respiratory distress syndrome | 98.08 | 10.64 | 84 | 84969 | 3726 | 29485748 |
Depression | 97.93 | 10.64 | 494 | 84559 | 84653 | 29404821 |
Akathisia | 95.20 | 10.64 | 107 | 84946 | 6635 | 29482839 |
Loss of libido | 94.87 | 10.64 | 67 | 84986 | 2229 | 29487245 |
Confusional state | 90.16 | 10.64 | 653 | 84400 | 127224 | 29362250 |
Tearfulness | 89.90 | 10.64 | 57 | 84996 | 1579 | 29487895 |
Hypertonia neonatal | 89.12 | 10.64 | 36 | 85017 | 364 | 29489110 |
Small for dates baby | 88.27 | 10.64 | 77 | 84976 | 3502 | 29485972 |
Depressed mood | 87.28 | 10.64 | 164 | 84889 | 16284 | 29473190 |
Disturbance in attention | 86.81 | 10.64 | 191 | 84862 | 21233 | 29468241 |
Increased appetite | 85.22 | 10.64 | 96 | 84957 | 5968 | 29483506 |
Euphoric mood | 84.79 | 10.64 | 86 | 84967 | 4739 | 29484735 |
Atrial septal defect | 82.91 | 10.64 | 100 | 84953 | 6689 | 29482785 |
Pneumonia | 78.63 | 10.64 | 569 | 84484 | 319603 | 29169871 |
Tremor | 78.53 | 10.64 | 418 | 84635 | 73120 | 29416354 |
Intrusive thoughts | 78.38 | 10.64 | 29 | 85024 | 226 | 29489248 |
Depression suicidal | 75.23 | 10.64 | 47 | 85006 | 1268 | 29488206 |
Erectile dysfunction | 73.46 | 10.64 | 161 | 84892 | 17848 | 29471626 |
Sexual dysfunction | 73.24 | 10.64 | 87 | 84966 | 5727 | 29483747 |
Asphyxia | 67.72 | 10.64 | 80 | 84973 | 5235 | 29484239 |
Temperature regulation disorder | 63.89 | 10.64 | 32 | 85021 | 554 | 29488920 |
Depressive symptom | 63.85 | 10.64 | 47 | 85006 | 1670 | 29487804 |
Homicidal ideation | 63.65 | 10.64 | 55 | 84998 | 2469 | 29487005 |
Cardio-respiratory arrest | 62.70 | 10.64 | 300 | 84753 | 50301 | 29439173 |
Acute kidney injury | 62.37 | 10.64 | 477 | 84576 | 264790 | 29224684 |
Interstitial lung disease | 61.04 | 10.64 | 46 | 85007 | 57672 | 29431802 |
Anger | 60.81 | 10.64 | 111 | 84942 | 10779 | 29478695 |
Psychiatric decompensation | 60.09 | 10.64 | 43 | 85010 | 1461 | 29488013 |
Maternal drugs affecting foetus | 58.79 | 10.64 | 64 | 84989 | 3829 | 29485645 |
Malignant neoplasm progression | 58.41 | 10.64 | 76 | 84977 | 73783 | 29415691 |
Hepatic function abnormal | 58.34 | 10.64 | 20 | 85033 | 39239 | 29450235 |
Neonatal seizure | 57.44 | 10.64 | 28 | 85025 | 456 | 29489018 |
Accidental death | 57.19 | 10.64 | 48 | 85005 | 2070 | 29487404 |
Intentional product misuse | 57.14 | 10.64 | 224 | 84829 | 34437 | 29455037 |
Diarrhoea | 54.89 | 10.64 | 653 | 84400 | 332045 | 29157429 |
Cryptorchism | 54.49 | 10.64 | 45 | 85008 | 1897 | 29487577 |
Sepsis | 54.04 | 10.64 | 219 | 84834 | 142463 | 29347011 |
Libido decreased | 53.62 | 10.64 | 64 | 84989 | 4234 | 29485240 |
Somnambulism | 53.09 | 10.64 | 52 | 85001 | 2746 | 29486728 |
Sopor | 53.08 | 10.64 | 105 | 84948 | 10829 | 29478645 |
Septic shock | 53.02 | 10.64 | 61 | 84992 | 62499 | 29426975 |
Hallucination, auditory | 52.58 | 10.64 | 97 | 84956 | 9496 | 29479978 |
Fall | 51.37 | 10.64 | 754 | 84299 | 176424 | 29313050 |
Sedation | 51.04 | 10.64 | 137 | 84916 | 17268 | 29472206 |
Somnolence | 50.96 | 10.64 | 452 | 84601 | 93503 | 29395971 |
Muscle twitching | 50.22 | 10.64 | 86 | 84967 | 7940 | 29481534 |
Homicide | 50.17 | 10.64 | 32 | 85021 | 896 | 29488578 |
Exposure during pregnancy | 50.07 | 10.64 | 89 | 84964 | 8465 | 29481009 |
Hallucination | 48.96 | 10.64 | 256 | 84797 | 44456 | 29445018 |
Muscle rigidity | 48.89 | 10.64 | 93 | 84960 | 9318 | 29480156 |
Cytomegalovirus infection | 48.83 | 10.64 | 5 | 85048 | 23210 | 29466264 |
Mydriasis | 48.78 | 10.64 | 73 | 84980 | 6012 | 29483462 |
Hypospadias | 48.23 | 10.64 | 51 | 85002 | 2951 | 29486523 |
Orgasmic sensation decreased | 48.19 | 10.64 | 14 | 85039 | 44 | 29489430 |
Platelet count decreased | 48.09 | 10.64 | 148 | 84905 | 104524 | 29384950 |
Tachyphrenia | 48.04 | 10.64 | 34 | 85019 | 1135 | 29488339 |
Prescription drug used without a prescription | 46.93 | 10.64 | 35 | 85018 | 1269 | 29488205 |
Panic attack | 46.65 | 10.64 | 85 | 84968 | 8241 | 29481233 |
Mental impairment | 45.85 | 10.64 | 89 | 84964 | 9052 | 29480422 |
Coma scale abnormal | 45.50 | 10.64 | 53 | 85000 | 3416 | 29486058 |
Poverty of speech | 45.30 | 10.64 | 19 | 85034 | 213 | 29489261 |
Neonatal hypoxia | 44.98 | 10.64 | 22 | 85031 | 361 | 29489113 |
Bradycardia neonatal | 44.91 | 10.64 | 30 | 85023 | 910 | 29488564 |
Multiple organ dysfunction syndrome | 44.89 | 10.64 | 70 | 84983 | 63046 | 29426428 |
Drug screen positive | 44.81 | 10.64 | 55 | 84998 | 3746 | 29485728 |
Obesity | 44.64 | 10.64 | 92 | 84961 | 9771 | 29479703 |
Derealisation | 44.39 | 10.64 | 25 | 85028 | 554 | 29488920 |
Logorrhoea | 44.31 | 10.64 | 43 | 85010 | 2245 | 29487229 |
Psychomotor skills impaired | 44.17 | 10.64 | 46 | 85007 | 2615 | 29486859 |
Cardiac arrest | 43.97 | 10.64 | 407 | 84646 | 85184 | 29404290 |
Cardiac failure | 42.47 | 10.64 | 104 | 84949 | 79183 | 29410291 |
Renal failure | 42.44 | 10.64 | 186 | 84867 | 118413 | 29371061 |
Mood swings | 41.87 | 10.64 | 75 | 84978 | 7176 | 29482298 |
Hanging | 41.21 | 10.64 | 15 | 85038 | 111 | 29489363 |
Hallucination, visual | 40.86 | 10.64 | 115 | 84938 | 14900 | 29474574 |
Anorgasmia | 40.65 | 10.64 | 24 | 85029 | 583 | 29488891 |
Hypomania | 40.48 | 10.64 | 40 | 85013 | 2135 | 29487339 |
Haemangioma congenital | 39.49 | 10.64 | 22 | 85031 | 477 | 29488997 |
Hyperreflexia | 39.14 | 10.64 | 44 | 85009 | 2728 | 29486746 |
Product use in unapproved indication | 39.07 | 10.64 | 124 | 84929 | 86751 | 29402723 |
Withdrawal syndrome | 38.99 | 10.64 | 93 | 84960 | 10899 | 29478575 |
Hyperhidrosis | 38.93 | 10.64 | 318 | 84735 | 64222 | 29425252 |
Neutropenia | 38.86 | 10.64 | 221 | 84832 | 131490 | 29357984 |
Drug reaction with eosinophilia and systemic symptoms | 38.68 | 10.64 | 16 | 85037 | 27976 | 29461498 |
Drug ineffective | 38.63 | 10.64 | 775 | 84278 | 362395 | 29127079 |
Hypoglycaemia neonatal | 38.37 | 10.64 | 35 | 85018 | 1689 | 29487785 |
Vasoplegia syndrome | 38.31 | 10.64 | 33 | 85020 | 1475 | 29487999 |
Prescribed overdose | 38.13 | 10.64 | 80 | 84973 | 8603 | 29480871 |
Depressed level of consciousness | 38.04 | 10.64 | 208 | 84845 | 36734 | 29452740 |
Congenital ureteropelvic junction obstruction | 37.26 | 10.64 | 12 | 85041 | 58 | 29489416 |
Amnesia | 37.04 | 10.64 | 146 | 84907 | 22497 | 29466977 |
Genital hypoaesthesia | 36.89 | 10.64 | 16 | 85037 | 196 | 29489278 |
Alcohol use | 36.40 | 10.64 | 45 | 85008 | 3087 | 29486387 |
Drug withdrawal syndrome | 36.18 | 10.64 | 124 | 84929 | 17860 | 29471614 |
Drug resistance | 35.60 | 10.64 | 9 | 85044 | 21531 | 29467943 |
Stomatitis | 35.03 | 10.64 | 33 | 85020 | 37080 | 29452394 |
Anaemia | 34.74 | 10.64 | 390 | 84663 | 200561 | 29288913 |
Atrial fibrillation | 34.64 | 10.64 | 171 | 84882 | 105475 | 29383999 |
Congenital hepatomegaly | 34.54 | 10.64 | 9 | 85044 | 16 | 29489458 |
Disease progression | 34.04 | 10.64 | 121 | 84932 | 81795 | 29407679 |
Inappropriate antidiuretic hormone secretion | 34.04 | 10.64 | 88 | 84965 | 10844 | 29478630 |
Electrocardiogram QRS complex prolonged | 33.94 | 10.64 | 50 | 85003 | 4060 | 29485414 |
Premature ejaculation | 33.90 | 10.64 | 13 | 85040 | 113 | 29489361 |
Mucosal inflammation | 33.63 | 10.64 | 25 | 85028 | 31570 | 29457904 |
Parathyroid gland enlargement | 33.51 | 10.64 | 13 | 85040 | 117 | 29489357 |
Pleural effusion | 33.49 | 10.64 | 101 | 84952 | 71807 | 29417667 |
Rhinitis perennial | 33.25 | 10.64 | 15 | 85038 | 203 | 29489271 |
Renal impairment | 33.23 | 10.64 | 121 | 84932 | 81212 | 29408262 |
Bipolar disorder | 33.04 | 10.64 | 44 | 85009 | 3251 | 29486223 |
Mania | 32.58 | 10.64 | 75 | 84978 | 8588 | 29480886 |
Respiratory failure | 32.55 | 10.64 | 156 | 84897 | 96975 | 29392499 |
Dyskinesia | 32.53 | 10.64 | 129 | 84924 | 19932 | 29469542 |
Infantile apnoea | 32.40 | 10.64 | 24 | 85029 | 861 | 29488613 |
Upper respiratory fungal infection | 32.40 | 10.64 | 13 | 85040 | 129 | 29489345 |
Negative thoughts | 32.36 | 10.64 | 21 | 85032 | 606 | 29488868 |
Newborn persistent pulmonary hypertension | 31.74 | 10.64 | 12 | 85041 | 100 | 29489374 |
Hyperventilation | 30.83 | 10.64 | 36 | 85017 | 2326 | 29487148 |
Apgar score low | 30.79 | 10.64 | 23 | 85030 | 836 | 29488638 |
Dyslipidaemia | 30.38 | 10.64 | 59 | 84994 | 6002 | 29483472 |
Gun shot wound | 30.15 | 10.64 | 25 | 85028 | 1060 | 29488414 |
Neuropathy peripheral | 30.12 | 10.64 | 104 | 84949 | 70923 | 29418551 |
Rheumatoid arthritis | 29.86 | 10.64 | 29 | 85024 | 32123 | 29457351 |
Oedema peripheral | 29.86 | 10.64 | 175 | 84878 | 103382 | 29386092 |
Psychomotor hyperactivity | 29.68 | 10.64 | 70 | 84983 | 8143 | 29481331 |
Circulatory collapse | 29.41 | 10.64 | 119 | 84934 | 18554 | 29470920 |
Loss of consciousness | 29.35 | 10.64 | 334 | 84719 | 73722 | 29415752 |
Optic nerve hypoplasia | 29.13 | 10.64 | 6 | 85047 | 0 | 29489474 |
Forced expiratory volume | 28.85 | 10.64 | 11 | 85042 | 94 | 29489380 |
Nightmare | 28.70 | 10.64 | 85 | 84968 | 11332 | 29478142 |
Patent ductus arteriosus | 28.66 | 10.64 | 40 | 85013 | 3091 | 29486383 |
Tardive dyskinesia | 28.60 | 10.64 | 53 | 85000 | 5205 | 29484269 |
Thrombocytopenia | 28.57 | 10.64 | 249 | 84804 | 134574 | 29354900 |
Apathy | 28.44 | 10.64 | 58 | 84995 | 6113 | 29483361 |
Congenital pulmonary hypertension | 28.03 | 10.64 | 9 | 85044 | 43 | 29489431 |
Toxicologic test abnormal | 27.87 | 10.64 | 18 | 85035 | 515 | 29488959 |
Mental disorder | 27.75 | 10.64 | 91 | 84962 | 12814 | 29476660 |
Failure to suspend medication | 27.57 | 10.64 | 16 | 85037 | 376 | 29489098 |
Spontaneous penile erection | 27.51 | 10.64 | 13 | 85040 | 197 | 29489277 |
Pancytopenia | 27.03 | 10.64 | 135 | 84918 | 83033 | 29406441 |
Hyperbilirubinaemia neonatal | 26.89 | 10.64 | 20 | 85033 | 722 | 29488752 |
Decreased appetite | 26.73 | 10.64 | 278 | 84775 | 145064 | 29344410 |
Torsade de pointes | 26.54 | 10.64 | 59 | 84994 | 6602 | 29482872 |
Disturbance in sexual arousal | 26.49 | 10.64 | 11 | 85042 | 120 | 29489354 |
Infection | 26.45 | 10.64 | 122 | 84931 | 76629 | 29412845 |
Foot deformity | 26.42 | 10.64 | 44 | 85009 | 3971 | 29485503 |
Pneumonitis | 26.39 | 10.64 | 25 | 85028 | 28019 | 29461455 |
Limb deformity | 26.12 | 10.64 | 17 | 85036 | 493 | 29488981 |
Impulsive behaviour | 26.01 | 10.64 | 30 | 85023 | 1913 | 29487561 |
Clonus | 25.78 | 10.64 | 33 | 85020 | 2345 | 29487129 |
Tremor neonatal | 25.75 | 10.64 | 15 | 85038 | 355 | 29489119 |
Sexual relationship change | 25.70 | 10.64 | 7 | 85046 | 16 | 29489458 |
Hospitalisation | 25.66 | 10.64 | 59 | 84994 | 45929 | 29443545 |
Disseminated intravascular coagulation | 25.15 | 10.64 | 13 | 85040 | 19967 | 29469507 |
Radiologically isolated syndrome | 24.98 | 10.64 | 6 | 85047 | 6 | 29489468 |
Cytokine release syndrome | 24.76 | 10.64 | 4 | 85049 | 13115 | 29476359 |
COVID-19 | 24.60 | 10.64 | 41 | 85012 | 35973 | 29453501 |
Selective eating disorder | 24.52 | 10.64 | 27 | 85026 | 1636 | 29487838 |
Disorientation | 24.47 | 10.64 | 157 | 84896 | 29358 | 29460116 |
Myoclonus | 24.39 | 10.64 | 89 | 84964 | 13220 | 29476254 |
Congenital hypercoagulation | 24.27 | 10.64 | 5 | 85048 | 0 | 29489474 |
Unresponsive to stimuli | 24.22 | 10.64 | 139 | 84914 | 24987 | 29464487 |
Pneumocystis jirovecii pneumonia | 24.15 | 10.64 | 9 | 85044 | 16770 | 29472704 |
Panic reaction | 24.13 | 10.64 | 24 | 85029 | 1291 | 29488183 |
Seizure | 24.11 | 10.64 | 389 | 84664 | 92734 | 29396740 |
Peripheral swelling | 23.98 | 10.64 | 98 | 84955 | 63641 | 29425833 |
Conduction disorder | 23.95 | 10.64 | 28 | 85025 | 1812 | 29487662 |
Hypertonia | 23.92 | 10.64 | 41 | 85012 | 3788 | 29485686 |
Hand deformity | 23.79 | 10.64 | 30 | 85023 | 2100 | 29487374 |
C-reactive protein increased | 23.73 | 10.64 | 58 | 84995 | 44205 | 29445269 |
Antipsychotic drug level increased | 23.32 | 10.64 | 37 | 85016 | 3206 | 29486268 |
Heat stroke | 23.31 | 10.64 | 20 | 85033 | 889 | 29488585 |
Dyspnoea | 23.13 | 10.64 | 740 | 84313 | 325992 | 29163482 |
Parkinsonism | 23.08 | 10.64 | 59 | 84994 | 7219 | 29482255 |
Congenital central nervous system anomaly | 22.90 | 10.64 | 15 | 85038 | 440 | 29489034 |
Neonatal pneumonia | 22.88 | 10.64 | 10 | 85043 | 125 | 29489349 |
Drug hypersensitivity | 22.83 | 10.64 | 110 | 84943 | 68296 | 29421178 |
Kinematic imbalances due to suboccipital strain | 22.57 | 10.64 | 6 | 85047 | 12 | 29489462 |
Oedema | 22.54 | 10.64 | 52 | 85001 | 40431 | 29449043 |
Weight increased | 22.43 | 10.64 | 327 | 84726 | 76340 | 29413134 |
Tic | 22.36 | 10.64 | 27 | 85026 | 1808 | 29487666 |
Myocardial infarction | 22.35 | 10.64 | 206 | 84847 | 110090 | 29379384 |
Bladder trabeculation | 21.93 | 10.64 | 5 | 85048 | 3 | 29489471 |
Brain oedema | 21.79 | 10.64 | 81 | 84972 | 12139 | 29477335 |
Eosinophilia | 21.75 | 10.64 | 19 | 85034 | 22142 | 29467332 |
Dreamy state | 21.65 | 10.64 | 6 | 85047 | 15 | 29489459 |
Leukaemia | 21.48 | 10.64 | 39 | 85014 | 3771 | 29485703 |
Major depression | 21.29 | 10.64 | 39 | 85014 | 3796 | 29485678 |
Neonatal disorder | 21.27 | 10.64 | 18 | 85035 | 785 | 29488689 |
Congenital hydronephrosis | 21.22 | 10.64 | 17 | 85036 | 686 | 29488788 |
Bronchopulmonary aspergillosis | 20.71 | 10.64 | 5 | 85048 | 12339 | 29477135 |
Blood alcohol increased | 20.66 | 10.64 | 17 | 85036 | 713 | 29488761 |
Myocardial fibrosis | 20.55 | 10.64 | 20 | 85033 | 1048 | 29488426 |
Postmortem blood drug level increased | 20.54 | 10.64 | 11 | 85042 | 220 | 29489254 |
Thrombosis | 20.36 | 10.64 | 60 | 84993 | 42985 | 29446489 |
Impaired work ability | 20.30 | 10.64 | 48 | 85005 | 5592 | 29483882 |
Interstitial granulomatous dermatitis | 20.29 | 10.64 | 10 | 85043 | 167 | 29489307 |
Haemophagocytic lymphohistiocytosis | 20.28 | 10.64 | 3 | 85050 | 10501 | 29478973 |
Gender dysphoria | 20.21 | 10.64 | 7 | 85046 | 44 | 29489430 |
Oesophageal perforation | 20.16 | 10.64 | 17 | 85036 | 738 | 29488736 |
Lactic acidosis | 20.14 | 10.64 | 35 | 85018 | 30212 | 29459262 |
Psychomotor retardation | 20.10 | 10.64 | 33 | 85020 | 2943 | 29486531 |
Agoraphobia | 20.06 | 10.64 | 11 | 85042 | 231 | 29489243 |
Maternal exposure during breast feeding | 19.99 | 10.64 | 23 | 85030 | 1463 | 29488011 |
Pilonidal cyst congenital | 19.95 | 10.64 | 6 | 85047 | 22 | 29489452 |
Bone marrow failure | 19.93 | 10.64 | 30 | 85023 | 27419 | 29462055 |
Cough | 19.92 | 10.64 | 251 | 84802 | 126476 | 29362998 |
Nasopharyngitis | 19.87 | 10.64 | 96 | 84957 | 59569 | 29429905 |
Pulmonary oedema | 19.84 | 10.64 | 199 | 84854 | 42536 | 29446938 |
Victim of chemical submission | 19.81 | 10.64 | 7 | 85046 | 47 | 29489427 |
Epistaxis | 19.76 | 10.64 | 79 | 84974 | 51625 | 29437849 |
Adjustment disorder | 19.74 | 10.64 | 19 | 85034 | 982 | 29488492 |
Ventricular septal defect | 19.73 | 10.64 | 36 | 85017 | 3493 | 29485981 |
Tachycardia | 19.69 | 10.64 | 305 | 84748 | 72105 | 29417369 |
Drug-induced liver injury | 19.57 | 10.64 | 20 | 85033 | 21635 | 29467839 |
Infusion related reaction | 19.46 | 10.64 | 63 | 84990 | 43823 | 29445651 |
Mental status changes | 19.40 | 10.64 | 169 | 84884 | 34758 | 29454716 |
Hyponatraemic syndrome | 19.37 | 10.64 | 10 | 85043 | 185 | 29489289 |
Rash | 19.22 | 10.64 | 408 | 84645 | 189411 | 29300063 |
Haematuria | 19.13 | 10.64 | 64 | 84989 | 44075 | 29445399 |
Decreased interest | 19.10 | 10.64 | 27 | 85026 | 2111 | 29487363 |
Synovitis | 19.09 | 10.64 | 4 | 85049 | 10886 | 29478588 |
Tumour lysis syndrome | 19.07 | 10.64 | 8 | 85045 | 13876 | 29475598 |
Persistent foetal circulation | 18.97 | 10.64 | 12 | 85041 | 331 | 29489143 |
Delusion | 18.89 | 10.64 | 73 | 84980 | 11143 | 29478331 |
Hyponatraemia | 18.82 | 10.64 | 286 | 84767 | 67347 | 29422127 |
Dysphemia | 18.76 | 10.64 | 22 | 85031 | 1428 | 29488046 |
Osmolar gap abnormal | 18.63 | 10.64 | 6 | 85047 | 29 | 29489445 |
Choanal atresia | 18.49 | 10.64 | 5 | 85048 | 11 | 29489463 |
Substance abuse | 18.48 | 10.64 | 52 | 85001 | 6735 | 29482739 |
Anhidrosis | 18.44 | 10.64 | 8 | 85045 | 98 | 29489376 |
Hyperbilirubinaemia | 18.38 | 10.64 | 10 | 85043 | 14924 | 29474550 |
Constipation | 18.36 | 10.64 | 225 | 84828 | 113935 | 29375539 |
Schizoaffective disorder | 18.34 | 10.64 | 19 | 85034 | 1073 | 29488401 |
Feeling abnormal | 18.27 | 10.64 | 238 | 84815 | 54207 | 29435267 |
Drug dependence | 18.25 | 10.64 | 113 | 84940 | 20868 | 29468606 |
Parkinson's disease | 18.20 | 10.64 | 21 | 85032 | 1340 | 29488134 |
Intestinal congestion | 18.19 | 10.64 | 5 | 85048 | 12 | 29489462 |
Suicidal behaviour | 18.14 | 10.64 | 21 | 85032 | 1344 | 29488130 |
Periventricular leukomalacia | 18.14 | 10.64 | 6 | 85047 | 32 | 29489442 |
Duodenal ulcer perforation | 18.09 | 10.64 | 22 | 85031 | 1484 | 29487990 |
Hypotonia neonatal | 18.07 | 10.64 | 20 | 85033 | 1219 | 29488255 |
Diffuse large B-cell lymphoma stage II | 17.99 | 10.64 | 6 | 85047 | 33 | 29489441 |
Hypertrophic cardiomyopathy | 17.93 | 10.64 | 17 | 85036 | 862 | 29488612 |
Hepatitis C virus test positive | 17.90 | 10.64 | 11 | 85042 | 288 | 29489186 |
Joint swelling | 17.62 | 10.64 | 78 | 84975 | 49552 | 29439922 |
Finnegan score increased | 17.38 | 10.64 | 5 | 85048 | 15 | 29489459 |
Exposure via ingestion | 17.32 | 10.64 | 25 | 85028 | 1993 | 29487481 |
Toxic epidermal necrolysis | 17.29 | 10.64 | 16 | 85037 | 18137 | 29471337 |
Acute myocardial infarction | 17.28 | 10.64 | 76 | 84977 | 48362 | 29441112 |
Libido disorder | 17.08 | 10.64 | 10 | 85043 | 239 | 29489235 |
Facial spasm | 17.03 | 10.64 | 9 | 85044 | 175 | 29489299 |
Blood bilirubin increased | 16.95 | 10.64 | 46 | 85007 | 33847 | 29455627 |
Neonatal infection | 16.94 | 10.64 | 12 | 85041 | 401 | 29489073 |
Myelosuppression | 16.87 | 10.64 | 7 | 85046 | 12220 | 29477254 |
Jaundice | 16.82 | 10.64 | 37 | 85016 | 29259 | 29460215 |
Slow response to stimuli | 16.67 | 10.64 | 15 | 85038 | 711 | 29488763 |
Bronchopulmonary aspergillosis allergic | 16.65 | 10.64 | 13 | 85040 | 505 | 29488969 |
Pregnancy | 16.65 | 10.64 | 10 | 85043 | 251 | 29489223 |
Myelodysplastic syndrome | 16.58 | 10.64 | 16 | 85037 | 17778 | 29471696 |
Opiates positive | 16.57 | 10.64 | 13 | 85040 | 509 | 29488965 |
Urinary retention | 16.51 | 10.64 | 152 | 84901 | 31746 | 29457728 |
Hypercalcaemia | 16.51 | 10.64 | 8 | 85045 | 12751 | 29476723 |
Acute myeloid leukaemia | 16.40 | 10.64 | 14 | 85039 | 16499 | 29472975 |
Osteonecrosis of jaw | 16.39 | 10.64 | 14 | 85039 | 16496 | 29472978 |
Wrong patient received product | 16.36 | 10.64 | 26 | 85027 | 2256 | 29487218 |
Intentional product use issue | 16.20 | 10.64 | 65 | 84988 | 42433 | 29447041 |
Incontinence | 16.17 | 10.64 | 41 | 85012 | 4991 | 29484483 |
Economic problem | 16.11 | 10.64 | 19 | 85034 | 1241 | 29488233 |
Coordination abnormal | 16.05 | 10.64 | 51 | 85002 | 7063 | 29482411 |
Arachnoid cyst | 16.04 | 10.64 | 9 | 85044 | 198 | 29489276 |
Generalised tonic-clonic seizure | 15.98 | 10.64 | 102 | 84951 | 19037 | 29470437 |
Alcoholism | 15.98 | 10.64 | 28 | 85025 | 2633 | 29486841 |
Cyanosis neonatal | 15.97 | 10.64 | 10 | 85043 | 271 | 29489203 |
Acute stress disorder | 15.95 | 10.64 | 8 | 85045 | 139 | 29489335 |
Blood creatinine increased | 15.94 | 10.64 | 162 | 84891 | 84940 | 29404534 |
Poor feeding infant | 15.93 | 10.64 | 12 | 85041 | 442 | 29489032 |
Rectourethral fistula | 15.90 | 10.64 | 5 | 85048 | 22 | 29489452 |
Accidental poisoning | 15.80 | 10.64 | 13 | 85040 | 545 | 29488929 |
Spermatozoa morphology abnormal | 15.77 | 10.64 | 4 | 85049 | 6 | 29489468 |
Blood catecholamines decreased | 15.77 | 10.64 | 4 | 85049 | 6 | 29489468 |
Xanthoma | 15.77 | 10.64 | 7 | 85046 | 91 | 29489383 |
Infant irritability | 15.72 | 10.64 | 5 | 85048 | 23 | 29489451 |
Poor quality sleep | 15.54 | 10.64 | 51 | 85002 | 7182 | 29482292 |
Congenital pneumonia | 15.50 | 10.64 | 7 | 85046 | 95 | 29489379 |
Urticaria | 15.41 | 10.64 | 93 | 84960 | 54567 | 29434907 |
Influenza | 15.37 | 10.64 | 65 | 84988 | 41816 | 29447658 |
Caesarean section | 15.31 | 10.64 | 23 | 85030 | 1900 | 29487574 |
Colitis | 15.18 | 10.64 | 43 | 85010 | 31205 | 29458269 |
Morbid thoughts | 15.16 | 10.64 | 9 | 85044 | 221 | 29489253 |
Liver disorder | 15.16 | 10.64 | 36 | 85017 | 27713 | 29461761 |
Cardiac failure congestive | 15.09 | 10.64 | 144 | 84909 | 76437 | 29413037 |
Abnormal behaviour | 15.05 | 10.64 | 116 | 84937 | 23011 | 29466463 |
Positive end-expiratory pressure | 15.05 | 10.64 | 4 | 85049 | 8 | 29489466 |
Hydrocele | 15.04 | 10.64 | 23 | 85030 | 1930 | 29487544 |
Scleroderma renal crisis | 14.99 | 10.64 | 7 | 85046 | 103 | 29489371 |
Physical assault | 14.95 | 10.64 | 17 | 85036 | 1067 | 29488407 |
Eye haematoma | 14.91 | 10.64 | 6 | 85047 | 60 | 29489414 |
Anomaly of external ear congenital | 14.87 | 10.64 | 7 | 85046 | 105 | 29489369 |
Infantile vomiting | 14.77 | 10.64 | 5 | 85048 | 29 | 29489445 |
Cleft lip and palate | 14.69 | 10.64 | 10 | 85043 | 313 | 29489161 |
Resting tremor | 14.66 | 10.64 | 13 | 85040 | 604 | 29488870 |
Lymphoma | 14.61 | 10.64 | 5 | 85048 | 9823 | 29479651 |
Holoprosencephaly | 14.56 | 10.64 | 3 | 85050 | 0 | 29489474 |
Visual snow syndrome | 14.56 | 10.64 | 3 | 85050 | 0 | 29489474 |
Gas poisoning | 14.56 | 10.64 | 3 | 85050 | 0 | 29489474 |
Epilepsy congenital | 14.56 | 10.64 | 3 | 85050 | 0 | 29489474 |
Gastrointestinal mucosal exfoliation | 14.53 | 10.64 | 7 | 85046 | 111 | 29489363 |
Granulocytopenia | 14.47 | 10.64 | 44 | 85009 | 5950 | 29483524 |
Self-injurious ideation | 14.47 | 10.64 | 20 | 85033 | 1531 | 29487943 |
Genital anaesthesia | 14.44 | 10.64 | 4 | 85049 | 10 | 29489464 |
Hypertrophic scar | 14.44 | 10.64 | 4 | 85049 | 10 | 29489464 |
Haemoglobin decreased | 14.40 | 10.64 | 222 | 84831 | 108153 | 29381321 |
Accidental overdose | 14.22 | 10.64 | 93 | 84960 | 17500 | 29471974 |
Memory impairment | 14.22 | 10.64 | 164 | 84889 | 36306 | 29453168 |
JC virus CSF test positive | 14.14 | 10.64 | 7 | 85046 | 118 | 29489356 |
Hepatic failure | 14.13 | 10.64 | 45 | 85008 | 31467 | 29458007 |
Bacterial infection | 14.09 | 10.64 | 10 | 85043 | 12938 | 29476536 |
Radicular pain | 14.09 | 10.64 | 6 | 85047 | 70 | 29489404 |
Salivary hypersecretion | 13.96 | 10.64 | 50 | 85003 | 7359 | 29482115 |
White blood cell count decreased | 13.89 | 10.64 | 163 | 84890 | 83199 | 29406275 |
Thrombotic stroke | 13.86 | 10.64 | 9 | 85044 | 260 | 29489214 |
Pleurothotonus | 13.85 | 10.64 | 16 | 85037 | 1022 | 29488452 |
Priapism | 13.84 | 10.64 | 36 | 85017 | 4452 | 29485022 |
Pulmonary embolism | 13.80 | 10.64 | 147 | 84906 | 76387 | 29413087 |
Opisthotonus | 13.75 | 10.64 | 11 | 85042 | 443 | 29489031 |
Erythema | 13.72 | 10.64 | 145 | 84908 | 75461 | 29414013 |
Vestibular disorder | 13.65 | 10.64 | 16 | 85037 | 1038 | 29488436 |
Psychiatric symptom | 13.59 | 10.64 | 29 | 85024 | 3155 | 29486319 |
Ventricular flutter | 13.59 | 10.64 | 6 | 85047 | 77 | 29489397 |
Iron binding capacity total increased | 13.51 | 10.64 | 5 | 85048 | 39 | 29489435 |
Head circumference abnormal | 13.51 | 10.64 | 5 | 85048 | 39 | 29489435 |
Renal disorder | 13.42 | 10.64 | 28 | 85025 | 22567 | 29466907 |
Arthropathy | 13.41 | 10.64 | 26 | 85027 | 21528 | 29467946 |
Rhinorrhoea | 13.35 | 10.64 | 26 | 85027 | 21493 | 29467981 |
Abnormal dreams | 13.30 | 10.64 | 47 | 85006 | 6873 | 29482601 |
Brugada syndrome | 13.25 | 10.64 | 13 | 85040 | 688 | 29488786 |
Angle closure glaucoma | 13.22 | 10.64 | 14 | 85039 | 811 | 29488663 |
Liver function test increased | 13.17 | 10.64 | 9 | 85044 | 11876 | 29477598 |
Dyspnoea exertional | 13.17 | 10.64 | 57 | 84996 | 36433 | 29453041 |
Insomnia | 13.06 | 10.64 | 341 | 84712 | 88420 | 29401054 |
Cytopenia | 13.04 | 10.64 | 6 | 85047 | 9853 | 29479621 |
Congenital hydrocephalus | 12.81 | 10.64 | 6 | 85047 | 89 | 29489385 |
Dissociation | 12.77 | 10.64 | 16 | 85037 | 1113 | 29488361 |
Blood urea increased | 12.71 | 10.64 | 40 | 85013 | 28072 | 29461402 |
Micropenis | 12.70 | 10.64 | 5 | 85048 | 47 | 29489427 |
Cognitive disorder | 12.68 | 10.64 | 113 | 84940 | 23386 | 29466088 |
Teratogenicity | 12.61 | 10.64 | 5 | 85048 | 48 | 29489426 |
Activation syndrome | 12.57 | 10.64 | 6 | 85047 | 93 | 29489381 |
Testicular atrophy | 12.50 | 10.64 | 11 | 85042 | 506 | 29488968 |
Muscle mass | 12.48 | 10.64 | 8 | 85045 | 226 | 29489248 |
Crystalluria | 12.45 | 10.64 | 10 | 85043 | 405 | 29489069 |
Bronchial disorder | 12.41 | 10.64 | 16 | 85037 | 1145 | 29488329 |
Blood pressure fluctuation | 12.37 | 10.64 | 24 | 85029 | 19870 | 29469604 |
Staphylococcal sepsis | 12.35 | 10.64 | 5 | 85048 | 8857 | 29480617 |
Adjusted calcium increased | 12.31 | 10.64 | 4 | 85049 | 20 | 29489454 |
Respiratory distress | 12.30 | 10.64 | 49 | 85004 | 32057 | 29457417 |
Tendon disorder | 12.27 | 10.64 | 24 | 85029 | 2454 | 29487020 |
Carbon monoxide poisoning | 12.24 | 10.64 | 6 | 85047 | 99 | 29489375 |
Thinking abnormal | 12.24 | 10.64 | 38 | 85015 | 5198 | 29484276 |
Schizophrenia | 12.11 | 10.64 | 44 | 85009 | 6521 | 29482953 |
Personality change | 12.11 | 10.64 | 35 | 85018 | 4603 | 29484871 |
Male orgasmic disorder | 12.08 | 10.64 | 6 | 85047 | 102 | 29489372 |
Haematospermia | 12.03 | 10.64 | 9 | 85044 | 328 | 29489146 |
Leukopenia | 11.90 | 10.64 | 224 | 84829 | 54979 | 29434495 |
Pneumonia bacterial | 11.88 | 10.64 | 6 | 85047 | 9337 | 29480137 |
Coagulation factor increased | 11.85 | 10.64 | 5 | 85048 | 57 | 29489417 |
Product use issue | 11.79 | 10.64 | 93 | 84960 | 51351 | 29438123 |
Aspergillus infection | 11.75 | 10.64 | 8 | 85045 | 10573 | 29478901 |
Semen volume decreased | 11.66 | 10.64 | 9 | 85044 | 344 | 29489130 |
Social avoidant behaviour | 11.65 | 10.64 | 26 | 85027 | 2916 | 29486558 |
Pruritus | 11.56 | 10.64 | 252 | 84801 | 116597 | 29372877 |
Antipsychotic drug level above therapeutic | 11.50 | 10.64 | 15 | 85038 | 1086 | 29488388 |
Dystonia | 11.49 | 10.64 | 57 | 84996 | 9692 | 29479782 |
Pulmonary valve stenosis | 11.48 | 10.64 | 9 | 85044 | 352 | 29489122 |
Mood altered | 11.45 | 10.64 | 50 | 85003 | 8061 | 29481413 |
Kidney transplant rejection | 11.43 | 10.64 | 3 | 85050 | 7002 | 29482472 |
Angioedema | 11.42 | 10.64 | 50 | 85003 | 31865 | 29457609 |
Lacrimation increased | 11.37 | 10.64 | 3 | 85050 | 6977 | 29482497 |
Toxic skin eruption | 11.34 | 10.64 | 7 | 85046 | 9750 | 29479724 |
Long QT syndrome | 11.34 | 10.64 | 22 | 85031 | 2236 | 29487238 |
Genital pain | 11.33 | 10.64 | 7 | 85046 | 185 | 29489289 |
Tension | 11.32 | 10.64 | 20 | 85033 | 1893 | 29487581 |
Oesophageal atresia | 11.31 | 10.64 | 10 | 85043 | 463 | 29489011 |
Alcoholic psychosis | 11.28 | 10.64 | 3 | 85050 | 6 | 29489468 |
Personality disorder | 11.27 | 10.64 | 15 | 85038 | 1108 | 29488366 |
Coagulation factor VII level decreased | 11.25 | 10.64 | 6 | 85047 | 119 | 29489355 |
Application site hypersensitivity | 11.25 | 10.64 | 6 | 85047 | 119 | 29489355 |
Venoocclusive liver disease | 11.22 | 10.64 | 3 | 85050 | 6914 | 29482560 |
Musculoskeletal pain | 11.21 | 10.64 | 44 | 85009 | 28909 | 29460565 |
CSF test abnormal | 11.20 | 10.64 | 7 | 85046 | 189 | 29489285 |
Hyperuricaemia | 11.15 | 10.64 | 3 | 85050 | 6886 | 29482588 |
Myositis | 11.12 | 10.64 | 8 | 85045 | 10275 | 29479199 |
Drug abuser | 11.09 | 10.64 | 30 | 85023 | 3797 | 29485677 |
Pulmonary artery stenosis congenital | 11.08 | 10.64 | 10 | 85043 | 476 | 29488998 |
Renal vasculitis | 11.07 | 10.64 | 6 | 85047 | 123 | 29489351 |
Infertility | 11.07 | 10.64 | 7 | 85046 | 193 | 29489281 |
Graft versus host disease | 11.07 | 10.64 | 7 | 85046 | 9621 | 29479853 |
CSF white blood cell count positive | 11.06 | 10.64 | 4 | 85049 | 29 | 29489445 |
Yawning | 11.01 | 10.64 | 10 | 85043 | 480 | 29488994 |
Bradykinesia | 10.99 | 10.64 | 28 | 85025 | 3419 | 29486055 |
Hepatic enzyme increased | 10.89 | 10.64 | 55 | 84998 | 33744 | 29455730 |
Osteoporosis | 10.85 | 10.64 | 9 | 85044 | 10760 | 29478714 |
Palmar-plantar erythrodysaesthesia syndrome | 10.84 | 10.64 | 16 | 85037 | 14743 | 29474731 |
Self-medication | 10.83 | 10.64 | 21 | 85032 | 2133 | 29487341 |
Alcohol interaction | 10.83 | 10.64 | 24 | 85029 | 2679 | 29486795 |
Alcohol poisoning | 10.81 | 10.64 | 26 | 85027 | 3063 | 29486411 |
Emotional disorder | 10.80 | 10.64 | 35 | 85018 | 4896 | 29484578 |
Incoherent | 10.80 | 10.64 | 31 | 85022 | 4061 | 29485413 |
Bronchitis | 10.77 | 10.64 | 62 | 84991 | 36806 | 29452668 |
Bacteraemia | 10.76 | 10.64 | 19 | 85034 | 16304 | 29473170 |
Dysarthria | 10.73 | 10.64 | 136 | 84917 | 30775 | 29458699 |
HIV peripheral neuropathy | 10.72 | 10.64 | 4 | 85049 | 32 | 29489442 |
Seizure like phenomena | 10.71 | 10.64 | 11 | 85042 | 615 | 29488859 |
Alcohol abuse | 10.64 | 10.64 | 32 | 85021 | 4301 | 29485173 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 2004.19 | 9.84 | 3046 | 210765 | 221368 | 64063553 |
Toxicity to various agents | 1786.37 | 9.84 | 3801 | 210010 | 359712 | 63925209 |
Drug abuse | 1338.66 | 9.84 | 1907 | 211904 | 130467 | 64154454 |
Serotonin syndrome | 973.41 | 9.84 | 901 | 212910 | 38381 | 64246540 |
Overdose | 641.35 | 9.84 | 1544 | 212267 | 158022 | 64126899 |
Electrocardiogram QT prolonged | 636.69 | 9.84 | 1028 | 212783 | 78420 | 64206501 |
Intentional overdose | 609.64 | 9.84 | 1080 | 212731 | 88864 | 64196057 |
Drug interaction | 536.37 | 9.84 | 2497 | 211314 | 359586 | 63925335 |
Suicidal ideation | 496.65 | 9.84 | 834 | 212977 | 65708 | 64219213 |
Suicide attempt | 435.86 | 9.84 | 817 | 212994 | 70190 | 64214731 |
Respiratory arrest | 323.05 | 9.84 | 608 | 213203 | 52377 | 64232544 |
Sopor | 320.94 | 9.84 | 442 | 213369 | 29219 | 64255702 |
Poisoning | 317.14 | 9.84 | 377 | 213434 | 21502 | 64263419 |
Intentional self-injury | 310.05 | 9.84 | 430 | 213381 | 28614 | 64256307 |
Agitation | 296.26 | 9.84 | 799 | 213012 | 87568 | 64197353 |
Anxiety | 279.24 | 9.84 | 1370 | 212441 | 201279 | 64083642 |
Synovitis | 258.43 | 9.84 | 18 | 213793 | 99072 | 64185849 |
Cardio-respiratory arrest | 248.06 | 9.84 | 804 | 213007 | 97589 | 64187332 |
Off label use | 247.83 | 9.84 | 1168 | 212643 | 631638 | 63653283 |
Drug ineffective | 247.79 | 9.84 | 1702 | 212109 | 838545 | 63446376 |
Torsade de pointes | 222.22 | 9.84 | 281 | 213530 | 17082 | 64267839 |
Febrile neutropenia | 207.17 | 9.84 | 190 | 213621 | 187467 | 64097454 |
Tremor | 206.82 | 9.84 | 1006 | 212805 | 147224 | 64137697 |
Hyponatraemia | 197.19 | 9.84 | 993 | 212818 | 147346 | 64137575 |
Temperature regulation disorder | 185.33 | 9.84 | 135 | 213676 | 4076 | 64280845 |
Hyperhidrosis | 167.23 | 9.84 | 838 | 212973 | 124082 | 64160839 |
Pyrexia | 165.41 | 9.84 | 1129 | 212682 | 557515 | 63727406 |
Systemic lupus erythematosus | 162.93 | 9.84 | 30 | 213781 | 77582 | 64207339 |
Restlessness | 162.72 | 9.84 | 388 | 213423 | 39397 | 64245524 |
Hand deformity | 161.94 | 9.84 | 12 | 213799 | 62759 | 64222162 |
Cardiac arrest | 159.61 | 9.84 | 964 | 212847 | 153100 | 64131821 |
Treatment failure | 158.95 | 9.84 | 95 | 213716 | 116721 | 64168200 |
Aggression | 155.83 | 9.84 | 419 | 213392 | 45813 | 64239108 |
Panic attack | 154.05 | 9.84 | 261 | 213550 | 20692 | 64264229 |
Confusional state | 148.16 | 9.84 | 1418 | 212393 | 259726 | 64025195 |
Disturbance in attention | 147.34 | 9.84 | 381 | 213430 | 40693 | 64244228 |
Depression | 136.86 | 9.84 | 1058 | 212753 | 182233 | 64102688 |
Drug intolerance | 136.21 | 9.84 | 260 | 213551 | 187732 | 64097189 |
Mydriasis | 136.19 | 9.84 | 208 | 213603 | 15104 | 64269817 |
Loss of libido | 136.17 | 9.84 | 90 | 213721 | 2314 | 64282607 |
Pemphigus | 135.13 | 9.84 | 20 | 213791 | 60681 | 64224240 |
Food allergy | 133.57 | 9.84 | 147 | 213664 | 7704 | 64277217 |
Electrocardiogram QRS complex prolonged | 133.47 | 9.84 | 159 | 213652 | 9085 | 64275836 |
Infusion related reaction | 132.27 | 9.84 | 213 | 213598 | 164254 | 64120667 |
Somnolence | 131.85 | 9.84 | 1138 | 212673 | 202507 | 64082414 |
Irritability | 130.92 | 9.84 | 340 | 213471 | 36406 | 64248515 |
Psychotic disorder | 130.52 | 9.84 | 327 | 213484 | 34251 | 64250670 |
Coeliac disease | 129.96 | 9.84 | 141 | 213670 | 7271 | 64277650 |
Pericarditis | 129.44 | 9.84 | 25 | 213786 | 62491 | 64222430 |
Fall | 127.88 | 9.84 | 2015 | 211796 | 414811 | 63870110 |
Withdrawal syndrome | 126.61 | 9.84 | 256 | 213555 | 23236 | 64261685 |
Anorgasmia | 123.01 | 9.84 | 61 | 213750 | 888 | 64284033 |
Pneumonia | 121.79 | 9.84 | 1227 | 212584 | 558349 | 63726572 |
Interstitial lung disease | 121.42 | 9.84 | 88 | 213723 | 97644 | 64187277 |
Paranoia | 117.98 | 9.84 | 202 | 213609 | 16150 | 64268771 |
Arthropathy | 115.96 | 9.84 | 138 | 213673 | 120829 | 64164092 |
Muscle twitching | 115.73 | 9.84 | 218 | 213593 | 18780 | 64266141 |
Malignant neoplasm progression | 110.08 | 9.84 | 127 | 213684 | 112744 | 64172177 |
Intentional product misuse | 107.52 | 9.84 | 500 | 213311 | 71795 | 64213126 |
Joint swelling | 107.08 | 9.84 | 361 | 213450 | 215021 | 64069900 |
Accidental overdose | 105.99 | 9.84 | 297 | 213514 | 33260 | 64251661 |
Depressed mood | 105.88 | 9.84 | 338 | 213473 | 40674 | 64244247 |
Nightmare | 105.18 | 9.84 | 222 | 213589 | 20771 | 64264150 |
Therapeutic product effect decreased | 104.90 | 9.84 | 137 | 213674 | 115214 | 64169707 |
Muscle rigidity | 104.58 | 9.84 | 199 | 213612 | 17274 | 64267647 |
Akathisia | 103.28 | 9.84 | 157 | 213654 | 11353 | 64273568 |
Seizure | 101.96 | 9.84 | 921 | 212890 | 165971 | 64118950 |
Rash | 100.69 | 9.84 | 1003 | 212808 | 457546 | 63827375 |
Myoclonus | 100.59 | 9.84 | 243 | 213568 | 24875 | 64260046 |
Septic shock | 99.23 | 9.84 | 122 | 213689 | 105315 | 64179606 |
Infection | 98.79 | 9.84 | 300 | 213511 | 184580 | 64100341 |
Product use in unapproved indication | 98.42 | 9.84 | 281 | 213530 | 176337 | 64108584 |
Neutropenia | 98.31 | 9.84 | 434 | 213377 | 239190 | 64045731 |
Helicobacter infection | 97.07 | 9.84 | 8 | 213803 | 38354 | 64246567 |
Coma scale abnormal | 96.60 | 9.84 | 124 | 213687 | 7650 | 64277271 |
Loss of consciousness | 96.44 | 9.84 | 830 | 212981 | 147535 | 64137386 |
Unresponsive to stimuli | 96.20 | 9.84 | 376 | 213435 | 50017 | 64234904 |
Rheumatoid factor positive | 95.13 | 9.84 | 5 | 213806 | 34933 | 64249988 |
Alopecia | 94.26 | 9.84 | 261 | 213550 | 165429 | 64119492 |
Hepatic function abnormal | 93.69 | 9.84 | 48 | 213763 | 64265 | 64220656 |
Drug withdrawal syndrome | 93.05 | 9.84 | 271 | 213540 | 31020 | 64253901 |
Acute kidney injury | 87.57 | 9.84 | 1010 | 212801 | 448230 | 63836691 |
Bruxism | 87.52 | 9.84 | 82 | 213729 | 3542 | 64281379 |
Accidental death | 87.50 | 9.84 | 83 | 213728 | 3642 | 64281279 |
Hyperreflexia | 87.23 | 9.84 | 113 | 213698 | 7035 | 64277886 |
Obsessive-compulsive disorder | 86.83 | 9.84 | 93 | 213718 | 4725 | 64280196 |
Cytomegalovirus infection | 83.38 | 9.84 | 12 | 213799 | 37187 | 64247734 |
Mania | 82.49 | 9.84 | 173 | 213638 | 16113 | 64268808 |
Hallucination | 81.47 | 9.84 | 465 | 213346 | 72323 | 64212598 |
Peripheral swelling | 79.16 | 9.84 | 390 | 213421 | 208763 | 64076158 |
Libido decreased | 78.67 | 9.84 | 88 | 213723 | 4696 | 64280225 |
Exposure via ingestion | 78.61 | 9.84 | 89 | 213722 | 4813 | 64280108 |
Pancytopenia | 77.65 | 9.84 | 231 | 213580 | 143078 | 64141843 |
Thrombocytopenia | 77.05 | 9.84 | 431 | 213380 | 223370 | 64061551 |
Depression suicidal | 75.68 | 9.84 | 64 | 213747 | 2411 | 64282510 |
Platelet count decreased | 75.45 | 9.84 | 293 | 213518 | 167418 | 64117503 |
Homicidal ideation | 73.53 | 9.84 | 71 | 213740 | 3186 | 64281735 |
Tearfulness | 73.51 | 9.84 | 84 | 213727 | 4589 | 64280332 |
Dyskinesia | 71.24 | 9.84 | 289 | 213522 | 39099 | 64245822 |
Glossodynia | 70.74 | 9.84 | 66 | 213745 | 64630 | 64220291 |
Stomatitis | 69.77 | 9.84 | 163 | 213648 | 109442 | 64175479 |
Inappropriate antidiuretic hormone secretion | 69.14 | 9.84 | 196 | 213615 | 22093 | 64262828 |
Alcoholism | 68.83 | 9.84 | 70 | 213741 | 3347 | 64281574 |
Disinhibition | 68.58 | 9.84 | 58 | 213753 | 2185 | 64282736 |
Abdominal discomfort | 68.39 | 9.84 | 341 | 213470 | 181981 | 64102940 |
Muscle injury | 68.34 | 9.84 | 5 | 213806 | 26432 | 64258489 |
Impulsive behaviour | 67.69 | 9.84 | 62 | 213749 | 2601 | 64282320 |
Erectile dysfunction | 67.32 | 9.84 | 137 | 213674 | 12490 | 64272431 |
Mucosal inflammation | 67.07 | 9.84 | 65 | 213746 | 62519 | 64222402 |
Anger | 67.05 | 9.84 | 156 | 213655 | 15585 | 64269336 |
Immunodeficiency | 66.72 | 9.84 | 158 | 213653 | 15966 | 64268955 |
Sepsis | 66.67 | 9.84 | 468 | 213343 | 229873 | 64055048 |
Psychomotor hyperactivity | 65.75 | 9.84 | 147 | 213664 | 14304 | 64270617 |
Long QT syndrome | 65.48 | 9.84 | 83 | 213728 | 5056 | 64279865 |
Sleep disorder due to general medical condition, insomnia type | 65.05 | 9.84 | 6 | 213805 | 26264 | 64258657 |
Mood swings | 64.66 | 9.84 | 164 | 213647 | 17304 | 64267617 |
Intrusive thoughts | 64.18 | 9.84 | 29 | 213782 | 338 | 64284583 |
Memory impairment | 64.09 | 9.84 | 495 | 213316 | 85187 | 64199734 |
Depressed level of consciousness | 63.46 | 9.84 | 475 | 213336 | 80961 | 64203960 |
Disease progression | 63.41 | 9.84 | 248 | 213563 | 141432 | 64143489 |
Galactorrhoea | 63.12 | 9.84 | 65 | 213746 | 3154 | 64281767 |
C-reactive protein increased | 62.97 | 9.84 | 138 | 213673 | 94771 | 64190150 |
Cardiac failure | 62.96 | 9.84 | 226 | 213585 | 132147 | 64152774 |
Multiple organ dysfunction syndrome | 62.03 | 9.84 | 154 | 213657 | 101259 | 64183662 |
Tachyphrenia | 58.37 | 9.84 | 49 | 213762 | 1827 | 64283094 |
Wound | 57.80 | 9.84 | 103 | 213708 | 76374 | 64208547 |
Drug resistance | 57.74 | 9.84 | 22 | 213789 | 35080 | 64249841 |
Intentional product use issue | 57.41 | 9.84 | 146 | 213665 | 95218 | 64189703 |
Bursitis | 57.21 | 9.84 | 179 | 213632 | 21306 | 64263615 |
Renal impairment | 56.87 | 9.84 | 242 | 213569 | 134775 | 64150146 |
Sexual dysfunction | 56.27 | 9.84 | 87 | 213724 | 6384 | 64278537 |
Generalised tonic-clonic seizure | 55.85 | 9.84 | 271 | 213540 | 39586 | 64245335 |
Orgasmic sensation decreased | 54.99 | 9.84 | 15 | 213796 | 28 | 64284893 |
Self-injurious ideation | 54.63 | 9.84 | 60 | 213751 | 3137 | 64281784 |
Disturbance in sexual arousal | 54.49 | 9.84 | 21 | 213790 | 158 | 64284763 |
Disorientation | 53.76 | 9.84 | 343 | 213468 | 55485 | 64229436 |
Depressive symptom | 53.19 | 9.84 | 70 | 213741 | 4426 | 64280495 |
Drug dependence | 52.19 | 9.84 | 234 | 213577 | 33078 | 64251843 |
Alcohol use | 51.91 | 9.84 | 70 | 213741 | 4532 | 64280389 |
C-reactive protein abnormal | 51.59 | 9.84 | 16 | 213795 | 29031 | 64255890 |
Yawning | 51.29 | 9.84 | 38 | 213773 | 1178 | 64283743 |
Homicide | 50.88 | 9.84 | 37 | 213774 | 1114 | 64283807 |
Hallucination, auditory | 50.64 | 9.84 | 147 | 213664 | 16792 | 64268129 |
Amnesia | 50.52 | 9.84 | 303 | 213508 | 47966 | 64236955 |
Anaemia | 50.30 | 9.84 | 918 | 212893 | 377762 | 63907159 |
Parkinsonism | 50.17 | 9.84 | 132 | 213679 | 14241 | 64270680 |
Dyspnoea | 50.14 | 9.84 | 1913 | 211898 | 716761 | 63568160 |
Myocardial stunning | 50.00 | 9.84 | 20 | 213791 | 168 | 64284753 |
Pneumocystis jirovecii pneumonia | 49.48 | 9.84 | 15 | 213796 | 27619 | 64257302 |
Contraindicated product administered | 49.36 | 9.84 | 187 | 213624 | 107642 | 64177279 |
Cardiac failure congestive | 49.08 | 9.84 | 244 | 213567 | 130336 | 64154585 |
Cerebral vasoconstriction | 48.90 | 9.84 | 37 | 213774 | 1185 | 64283736 |
Duodenal ulcer perforation | 48.73 | 9.84 | 27 | 213784 | 34598 | 64250323 |
Drug screen positive | 48.39 | 9.84 | 76 | 213735 | 5653 | 64279268 |
Drug reaction with eosinophilia and systemic symptoms | 47.64 | 9.84 | 66 | 213745 | 54151 | 64230770 |
Dizziness | 46.29 | 9.84 | 1803 | 212008 | 428360 | 63856561 |
Hallucination, visual | 46.25 | 9.84 | 199 | 213612 | 27635 | 64257286 |
Pleural effusion | 46.13 | 9.84 | 239 | 213572 | 126320 | 64158601 |
Bone marrow failure | 45.61 | 9.84 | 55 | 213756 | 47897 | 64237024 |
Abnormal dreams | 45.61 | 9.84 | 104 | 213707 | 10252 | 64274669 |
Nasopharyngitis | 45.39 | 9.84 | 423 | 213388 | 195650 | 64089271 |
Diarrhoea | 45.19 | 9.84 | 1948 | 211863 | 720756 | 63564165 |
Renal failure | 44.67 | 9.84 | 386 | 213425 | 181302 | 64103619 |
Toxicologic test abnormal | 44.45 | 9.84 | 35 | 213776 | 1190 | 64283731 |
Liver disorder | 43.89 | 9.84 | 68 | 213743 | 53283 | 64231638 |
Mental disorder | 43.88 | 9.84 | 189 | 213622 | 26256 | 64258665 |
Haemophagocytic lymphohistiocytosis | 43.66 | 9.84 | 4 | 213807 | 17605 | 64267316 |
Atrial fibrillation | 43.63 | 9.84 | 360 | 213451 | 170729 | 64114192 |
Psychiatric decompensation | 43.43 | 9.84 | 47 | 213764 | 2416 | 64282505 |
Thinking abnormal | 43.30 | 9.84 | 109 | 213702 | 11447 | 64273474 |
Medication error | 43.28 | 9.84 | 299 | 213512 | 49667 | 64235254 |
Physical assault | 43.26 | 9.84 | 38 | 213773 | 1508 | 64283413 |
Asphyxia | 43.17 | 9.84 | 97 | 213714 | 9469 | 64275452 |
COVID-19 | 42.97 | 9.84 | 95 | 213716 | 65045 | 64219876 |
Haematemesis | 42.96 | 9.84 | 285 | 213526 | 46714 | 64238207 |
Insomnia | 42.74 | 9.84 | 906 | 212905 | 196930 | 64087991 |
Discomfort | 42.62 | 9.84 | 132 | 213679 | 80746 | 64204175 |
Lethargy | 42.45 | 9.84 | 397 | 213414 | 72197 | 64212724 |
Sinusitis | 42.43 | 9.84 | 296 | 213515 | 145632 | 64139289 |
Panic reaction | 42.03 | 9.84 | 59 | 213752 | 3968 | 64280953 |
Bradyphrenia | 42.03 | 9.84 | 95 | 213716 | 9311 | 64275610 |
Alcohol abuse | 41.87 | 9.84 | 65 | 213746 | 4787 | 64280134 |
Myelosuppression | 40.78 | 9.84 | 14 | 213797 | 23816 | 64261105 |
Negative thoughts | 40.13 | 9.84 | 34 | 213777 | 1284 | 64283637 |
Cytokine release syndrome | 39.73 | 9.84 | 10 | 213801 | 20819 | 64264102 |
Psychomotor skills impaired | 39.64 | 9.84 | 56 | 213755 | 3789 | 64281132 |
Major depression | 39.55 | 9.84 | 83 | 213728 | 7733 | 64277188 |
Dissociation | 38.95 | 9.84 | 49 | 213762 | 2962 | 64281959 |
Angle closure glaucoma | 38.85 | 9.84 | 46 | 213765 | 2611 | 64282310 |
Folliculitis | 38.77 | 9.84 | 26 | 213785 | 30051 | 64254870 |
Blister | 37.32 | 9.84 | 140 | 213671 | 80827 | 64204094 |
Sedation | 37.03 | 9.84 | 250 | 213561 | 41212 | 64243709 |
Bradycardia | 37.03 | 9.84 | 574 | 213237 | 117645 | 64167276 |
Bronchopulmonary aspergillosis | 36.72 | 9.84 | 9 | 213802 | 19076 | 64265845 |
Product use issue | 36.54 | 9.84 | 324 | 213487 | 151391 | 64133530 |
Acute myeloid leukaemia | 36.41 | 9.84 | 23 | 213788 | 27440 | 64257481 |
Mental impairment | 36.24 | 9.84 | 128 | 213683 | 16215 | 64268706 |
Clonus | 36.18 | 9.84 | 69 | 213742 | 5998 | 64278923 |
Nicotine dependence | 35.60 | 9.84 | 26 | 213785 | 788 | 64284133 |
Calcium deficiency | 35.55 | 9.84 | 25 | 213786 | 713 | 64284208 |
Premature ejaculation | 35.41 | 9.84 | 12 | 213799 | 59 | 64284862 |
Increased appetite | 35.23 | 9.84 | 93 | 213718 | 10053 | 64274868 |
Somnambulism | 35.12 | 9.84 | 62 | 213749 | 5079 | 64279842 |
Swelling | 34.81 | 9.84 | 351 | 213460 | 159867 | 64125054 |
Crying | 34.43 | 9.84 | 145 | 213666 | 19945 | 64264976 |
Maternal exposure during pregnancy | 34.42 | 9.84 | 182 | 213629 | 95702 | 64189219 |
Suicidal behaviour | 34.23 | 9.84 | 45 | 213766 | 2842 | 64282079 |
Catatonia | 34.09 | 9.84 | 77 | 213734 | 7543 | 64277378 |
Arthralgia | 33.96 | 9.84 | 1163 | 212648 | 441097 | 63843824 |
Extrapyramidal disorder | 33.42 | 9.84 | 141 | 213670 | 19411 | 64265510 |
Neuropathy peripheral | 33.37 | 9.84 | 240 | 213571 | 117285 | 64167636 |
Abnormal behaviour | 33.25 | 9.84 | 208 | 213603 | 33414 | 64251507 |
Logorrhoea | 33.12 | 9.84 | 53 | 213758 | 4006 | 64280915 |
Hypertonia | 32.98 | 9.84 | 68 | 213743 | 6257 | 64278664 |
Tic | 32.90 | 9.84 | 42 | 213769 | 2577 | 64282344 |
Aspartate aminotransferase increased | 32.88 | 9.84 | 247 | 213564 | 119541 | 64165380 |
Red blood cell sedimentation rate abnormal | 32.75 | 9.84 | 7 | 213804 | 16299 | 64268622 |
Bradykinesia | 32.42 | 9.84 | 69 | 213742 | 6491 | 64278430 |
Impaired healing | 32.35 | 9.84 | 98 | 213713 | 60375 | 64224546 |
Tumour lysis syndrome | 32.28 | 9.84 | 12 | 213799 | 19428 | 64265493 |
Blood creatinine increased | 31.81 | 9.84 | 292 | 213519 | 135490 | 64149431 |
Urinary retention | 31.79 | 9.84 | 275 | 213536 | 48926 | 64235995 |
Haematotoxicity | 31.78 | 9.84 | 3 | 213808 | 12893 | 64272028 |
Prescription drug used without a prescription | 31.57 | 9.84 | 41 | 213770 | 2559 | 64282362 |
Myelodysplastic syndrome | 31.50 | 9.84 | 27 | 213784 | 27552 | 64257369 |
Myocardial infarction | 31.35 | 9.84 | 375 | 213436 | 165446 | 64119475 |
Genital hypoaesthesia | 31.23 | 9.84 | 14 | 213797 | 160 | 64284761 |
Pneumonitis | 31.17 | 9.84 | 76 | 213735 | 50289 | 64234632 |
Palmar-plantar erythrodysaesthesia syndrome | 30.80 | 9.84 | 30 | 213781 | 28789 | 64256132 |
Drug eruption | 30.74 | 9.84 | 45 | 213766 | 36091 | 64248830 |
Irritable bowel syndrome | 30.38 | 9.84 | 48 | 213763 | 37321 | 64247600 |
Neutrophil count decreased | 30.30 | 9.84 | 142 | 213669 | 77054 | 64207867 |
Blood bilirubin increased | 30.27 | 9.84 | 94 | 213717 | 57459 | 64227462 |
Rhinitis perennial | 30.27 | 9.84 | 15 | 213796 | 218 | 64284703 |
Ill-defined disorder | 30.08 | 9.84 | 63 | 213748 | 43989 | 64240932 |
Toxic epidermal necrolysis | 29.97 | 9.84 | 48 | 213763 | 37118 | 64247803 |
Alcohol poisoning | 29.95 | 9.84 | 52 | 213759 | 4203 | 64280718 |
Rabbit syndrome | 29.89 | 9.84 | 17 | 213794 | 331 | 64284590 |
Hypomania | 29.73 | 9.84 | 61 | 213750 | 5593 | 64279328 |
Antidepressant drug level above therapeutic | 29.66 | 9.84 | 20 | 213791 | 532 | 64284389 |
Adrenal insufficiency | 29.58 | 9.84 | 19 | 213792 | 22468 | 64262453 |
Illness anxiety disorder | 29.38 | 9.84 | 15 | 213796 | 233 | 64284688 |
Apathy | 29.37 | 9.84 | 93 | 213718 | 11139 | 64273782 |
Ascites | 29.37 | 9.84 | 106 | 213705 | 61895 | 64223026 |
Hyperventilation | 29.36 | 9.84 | 68 | 213743 | 6772 | 64278149 |
Post viral fatigue syndrome | 29.25 | 9.84 | 16 | 213795 | 288 | 64284633 |
Antipsychotic drug level below therapeutic | 29.16 | 9.84 | 25 | 213786 | 960 | 64283961 |
Spontaneous penile erection | 29.09 | 9.84 | 12 | 213799 | 110 | 64284811 |
Prescribed overdose | 29.03 | 9.84 | 139 | 213672 | 20192 | 64264729 |
Derealisation | 28.98 | 9.84 | 30 | 213781 | 1465 | 64283456 |
Psychomotor retardation | 28.85 | 9.84 | 57 | 213754 | 5086 | 64279835 |
Coma | 28.82 | 9.84 | 429 | 213382 | 87186 | 64197735 |
Tardive dyskinesia | 28.75 | 9.84 | 81 | 213730 | 9097 | 64275824 |
Female sexual arousal disorder | 28.68 | 9.84 | 7 | 213804 | 6 | 64284915 |
Oedema peripheral | 28.45 | 9.84 | 508 | 213303 | 209809 | 64075112 |
Eosinophilia | 28.12 | 9.84 | 52 | 213759 | 38024 | 64246897 |
Hyponatraemic syndrome | 28.12 | 9.84 | 22 | 213789 | 741 | 64284180 |
Osteonecrosis of jaw | 28.01 | 9.84 | 56 | 213755 | 39769 | 64245152 |
Respiratory distress | 27.86 | 9.84 | 85 | 213726 | 52246 | 64232675 |
Neoplasm progression | 27.63 | 9.84 | 59 | 213752 | 40905 | 64244016 |
Pulseless electrical activity | 27.59 | 9.84 | 99 | 213712 | 12640 | 64272281 |
Haematuria | 27.58 | 9.84 | 105 | 213706 | 60366 | 64224555 |
Obesity | 27.51 | 9.84 | 138 | 213673 | 20424 | 64264497 |
Skin ulcer | 27.49 | 9.84 | 66 | 213745 | 43908 | 64241013 |
Hepatic enzyme increased | 27.27 | 9.84 | 287 | 213524 | 129656 | 64155265 |
Neonatal infection | 27.20 | 9.84 | 8 | 213803 | 22 | 64284899 |
Urticaria | 27.14 | 9.84 | 335 | 213476 | 146982 | 64137939 |
Hostility | 27.10 | 9.84 | 35 | 213776 | 2172 | 64282749 |
Product prescribing error | 27.05 | 9.84 | 205 | 213606 | 35064 | 64249857 |
Transplant rejection | 26.85 | 9.84 | 12 | 213799 | 17389 | 64267532 |
Posterior reversible encephalopathy syndrome | 26.78 | 9.84 | 22 | 213789 | 22924 | 64261997 |
Euphoric mood | 26.64 | 9.84 | 64 | 213747 | 6527 | 64278394 |
Pseudomonas infection | 26.56 | 9.84 | 13 | 213798 | 17870 | 64267051 |
Poverty of speech | 26.48 | 9.84 | 19 | 213792 | 560 | 64284361 |
Carcinoid heart disease | 26.44 | 9.84 | 9 | 213802 | 45 | 64284876 |
Circulatory collapse | 26.40 | 9.84 | 197 | 213614 | 33535 | 64251386 |
Sinus tachycardia | 26.35 | 9.84 | 190 | 213621 | 31998 | 64252923 |
Therapeutic product effect incomplete | 26.25 | 9.84 | 218 | 213593 | 103264 | 64181657 |
Postmortem blood drug level increased | 26.03 | 9.84 | 21 | 213790 | 740 | 64284181 |
Lower respiratory tract infection | 26.00 | 9.84 | 195 | 213616 | 94419 | 64190502 |
Myocardial fibrosis | 25.87 | 9.84 | 29 | 213782 | 1551 | 64283370 |
Gun shot wound | 25.55 | 9.84 | 24 | 213787 | 1040 | 64283881 |
Premature delivery | 25.43 | 9.84 | 15 | 213796 | 18574 | 64266347 |
Forced expiratory volume | 25.31 | 9.84 | 10 | 213801 | 81 | 64284840 |
Substance abuse | 25.28 | 9.84 | 78 | 213733 | 9214 | 64275707 |
Syncope | 25.26 | 9.84 | 693 | 213118 | 156942 | 64127979 |
Hospitalisation | 25.21 | 9.84 | 146 | 213665 | 75061 | 64209860 |
Hyperprolactinaemia | 25.19 | 9.84 | 47 | 213764 | 4018 | 64280903 |
Emotional distress | 25.18 | 9.84 | 205 | 213606 | 35833 | 64249088 |
Restless legs syndrome | 25.15 | 9.84 | 118 | 213693 | 16998 | 64267923 |
Injection site pain | 25.06 | 9.84 | 242 | 213569 | 111166 | 64173755 |
Alcohol interaction | 24.96 | 9.84 | 49 | 213762 | 4352 | 64280569 |
Drug hypersensitivity | 24.90 | 9.84 | 599 | 213212 | 237216 | 64047705 |
Thrombotic microangiopathy | 24.90 | 9.84 | 12 | 213799 | 16643 | 64268278 |
Arthritis | 24.85 | 9.84 | 169 | 213642 | 83645 | 64201276 |
Orgasm abnormal | 24.74 | 9.84 | 12 | 213799 | 166 | 64284755 |
Acute myocardial infarction | 24.65 | 9.84 | 133 | 213678 | 69585 | 64215336 |
Enterocolitis | 24.47 | 9.84 | 5 | 213806 | 12013 | 64272908 |
Incoherent | 24.47 | 9.84 | 65 | 213746 | 7053 | 64277868 |
Rheumatoid nodule | 24.27 | 9.84 | 6 | 213805 | 12645 | 64272276 |
Hypochloraemia | 24.25 | 9.84 | 32 | 213779 | 2029 | 64282892 |
Optic ischaemic neuropathy | 24.24 | 9.84 | 36 | 213775 | 2549 | 64282372 |
Radiologically isolated syndrome | 24.14 | 9.84 | 6 | 213805 | 6 | 64284915 |
Liver function test increased | 24.04 | 9.84 | 41 | 213770 | 30929 | 64253992 |
Delirium | 24.02 | 9.84 | 342 | 213469 | 68852 | 64216069 |
Pathogen resistance | 23.97 | 9.84 | 6 | 213805 | 12537 | 64272384 |
Parathyroid gland enlargement | 23.84 | 9.84 | 11 | 213800 | 135 | 64284786 |
Flat affect | 23.67 | 9.84 | 30 | 213781 | 1827 | 64283094 |
Knee arthroplasty | 23.58 | 9.84 | 33 | 213778 | 26966 | 64257955 |
Tachycardia | 23.52 | 9.84 | 656 | 213155 | 148923 | 64135998 |
Lactic acidosis | 23.49 | 9.84 | 114 | 213697 | 61296 | 64223625 |
Cholecystitis chronic | 23.47 | 9.84 | 76 | 213735 | 9211 | 64275710 |
Dystonia | 23.43 | 9.84 | 124 | 213687 | 18741 | 64266180 |
Alanine aminotransferase increased | 23.10 | 9.84 | 323 | 213488 | 138708 | 64146213 |
Cough | 23.05 | 9.84 | 795 | 213016 | 301353 | 63983568 |
Foetal chromosome abnormality | 22.81 | 9.84 | 6 | 213805 | 9 | 64284912 |
Dissociative amnesia | 22.80 | 9.84 | 10 | 213801 | 108 | 64284813 |
Hypokinesia | 22.64 | 9.84 | 112 | 213699 | 16484 | 64268437 |
Failure to suspend medication | 22.55 | 9.84 | 15 | 213796 | 390 | 64284531 |
Panic disorder | 22.49 | 9.84 | 36 | 213775 | 2721 | 64282200 |
Mental status changes | 22.32 | 9.84 | 305 | 213506 | 60857 | 64224064 |
Disseminated intravascular coagulation | 22.31 | 9.84 | 46 | 213765 | 32302 | 64252619 |
Neuropathy, ataxia, retinitis pigmentosa syndrome | 22.29 | 9.84 | 8 | 213803 | 48 | 64284873 |
Atonic urinary bladder | 22.25 | 9.84 | 9 | 213802 | 78 | 64284843 |
Rash erythematous | 22.25 | 9.84 | 253 | 213558 | 48380 | 64236541 |
Hypercalcaemia | 22.24 | 9.84 | 44 | 213767 | 31372 | 64253549 |
Nervousness | 22.23 | 9.84 | 171 | 213640 | 29385 | 64255536 |
Anhidrosis | 22.03 | 9.84 | 12 | 213799 | 214 | 64284707 |
Concussion | 21.94 | 9.84 | 67 | 213744 | 7871 | 64277050 |
Personality change | 21.43 | 9.84 | 70 | 213741 | 8523 | 64276398 |
Libido increased | 21.38 | 9.84 | 28 | 213783 | 1762 | 64283159 |
Dreamy state | 21.37 | 9.84 | 8 | 213803 | 55 | 64284866 |
Trisomy 18 | 21.22 | 9.84 | 5 | 213806 | 3 | 64284918 |
Brain injury | 21.20 | 9.84 | 77 | 213734 | 9888 | 64275033 |
Tension | 20.87 | 9.84 | 42 | 213769 | 3798 | 64281123 |
Schizoaffective disorder | 20.81 | 9.84 | 26 | 213785 | 1561 | 64283360 |
White blood cell count decreased | 20.78 | 9.84 | 383 | 213428 | 157454 | 64127467 |
Venoocclusive liver disease | 20.74 | 9.84 | 4 | 213807 | 10011 | 64274910 |
Dry mouth | 20.72 | 9.84 | 298 | 213513 | 60120 | 64224801 |
Neonatal seizure | 20.64 | 9.84 | 5 | 213806 | 4 | 64284917 |
Antipsychotic drug level above therapeutic | 20.52 | 9.84 | 28 | 213783 | 1833 | 64283088 |
Psoriatic arthropathy | 20.49 | 9.84 | 74 | 213737 | 43207 | 64241714 |
Herpes zoster | 20.45 | 9.84 | 166 | 213645 | 79021 | 64205900 |
Vascular access site thrombosis | 20.40 | 9.84 | 7 | 213804 | 36 | 64284885 |
Social avoidant behaviour | 20.33 | 9.84 | 46 | 213765 | 4511 | 64280410 |
Hanging | 20.30 | 9.84 | 9 | 213802 | 100 | 64284821 |
Epstein-Barr virus infection | 20.25 | 9.84 | 8 | 213803 | 12480 | 64272441 |
Pulmonary arterial hypertension | 20.23 | 9.84 | 33 | 213778 | 25334 | 64259587 |
Hypocalcaemia | 20.03 | 9.84 | 71 | 213740 | 41682 | 64243239 |
Loss of bladder sensation | 20.02 | 9.84 | 8 | 213803 | 67 | 64284854 |
Activation syndrome | 20.00 | 9.84 | 12 | 213799 | 259 | 64284662 |
Rash maculo-papular | 19.96 | 9.84 | 84 | 213727 | 46942 | 64237979 |
Head injury | 19.89 | 9.84 | 181 | 213630 | 32661 | 64252260 |
Poor quality sleep | 19.85 | 9.84 | 119 | 213692 | 18832 | 64266089 |
Facial spasm | 19.78 | 9.84 | 17 | 213794 | 655 | 64284266 |
Skin swelling | 19.73 | 9.84 | 34 | 213777 | 2732 | 64282189 |
Acute generalised exanthematous pustulosis | 19.72 | 9.84 | 11 | 213800 | 14047 | 64270874 |
Pupillary reflex impaired | 19.64 | 9.84 | 36 | 213775 | 3037 | 64281884 |
Dementia | 19.62 | 9.84 | 127 | 213684 | 20639 | 64264282 |
Hypogammaglobulinaemia | 19.54 | 9.84 | 5 | 213806 | 10294 | 64274627 |
Histrionic personality disorder | 19.51 | 9.84 | 7 | 213804 | 42 | 64284879 |
Interstitial granulomatous dermatitis | 19.49 | 9.84 | 11 | 213800 | 211 | 64284710 |
Bronchomalacia | 19.49 | 9.84 | 11 | 213800 | 211 | 64284710 |
Heat stroke | 19.34 | 9.84 | 24 | 213787 | 1431 | 64283490 |
Personality disorder | 19.31 | 9.84 | 46 | 213765 | 4665 | 64280256 |
Conduction disorder | 19.26 | 9.84 | 35 | 213776 | 2933 | 64281988 |
Cerebrospinal fluid retention | 19.24 | 9.84 | 8 | 213803 | 75 | 64284846 |
Hyperuricaemia | 19.23 | 9.84 | 5 | 213806 | 10186 | 64274735 |
Opiates positive | 19.20 | 9.84 | 19 | 213792 | 879 | 64284042 |
Cytomegalovirus viraemia | 19.16 | 9.84 | 6 | 213805 | 10822 | 64274099 |
Cytopenia | 19.11 | 9.84 | 14 | 213797 | 15457 | 64269464 |
Diaphragmatic rupture | 19.08 | 9.84 | 11 | 213800 | 220 | 64284701 |
Obsessive thoughts | 18.98 | 9.84 | 20 | 213791 | 997 | 64283924 |
Antidepressant drug level increased | 18.92 | 9.84 | 13 | 213798 | 357 | 64284564 |
Rib deformity | 18.92 | 9.84 | 9 | 213802 | 119 | 64284802 |
Epistaxis | 18.89 | 9.84 | 221 | 213590 | 97910 | 64187011 |
Spermatozoa morphology abnormal | 18.85 | 9.84 | 4 | 213807 | 0 | 64284921 |
Sexual inhibition | 18.85 | 9.84 | 4 | 213807 | 0 | 64284921 |
Nocturnal emission | 18.85 | 9.84 | 4 | 213807 | 0 | 64284921 |
Pruritus | 18.81 | 9.84 | 845 | 212966 | 311555 | 63973366 |
Hip arthroplasty | 18.75 | 9.84 | 26 | 213785 | 21325 | 64263596 |
Pregnancy | 18.74 | 9.84 | 126 | 213685 | 20739 | 64264182 |
Polyneuropathy | 18.73 | 9.84 | 23 | 213788 | 19871 | 64265050 |
Rheumatic fever | 18.65 | 9.84 | 4 | 213807 | 9290 | 64275631 |
Cognitive disorder | 18.61 | 9.84 | 271 | 213540 | 54816 | 64230105 |
Influenza | 18.60 | 9.84 | 245 | 213566 | 106286 | 64178635 |
Gender dysphoria | 18.60 | 9.84 | 7 | 213804 | 49 | 64284872 |
Decreased interest | 18.56 | 9.84 | 37 | 213774 | 3323 | 64281598 |
Agoraphobia | 18.51 | 9.84 | 15 | 213796 | 532 | 64284389 |
Drug-induced liver injury | 18.48 | 9.84 | 88 | 213723 | 47555 | 64237366 |
Intestinal congestion | 18.45 | 9.84 | 5 | 213806 | 9 | 64284912 |
Hyperbilirubinaemia | 18.44 | 9.84 | 26 | 213785 | 21179 | 64263742 |
Dysarthria | 18.42 | 9.84 | 288 | 213523 | 59118 | 64225803 |
Product dose omission issue | 18.38 | 9.84 | 498 | 213313 | 194249 | 64090672 |
Psychiatric symptom | 18.33 | 9.84 | 54 | 213757 | 6219 | 64278702 |
Thrombosis | 18.28 | 9.84 | 148 | 213663 | 70494 | 64214427 |
Abnormal weight gain | 18.20 | 9.84 | 29 | 213782 | 2184 | 64282737 |
Drug withdrawal syndrome neonatal | 18.19 | 9.84 | 11 | 213800 | 241 | 64284680 |
Blood alcohol increased | 18.18 | 9.84 | 21 | 213790 | 1161 | 64283760 |
Libido disorder | 18.11 | 9.84 | 11 | 213800 | 243 | 64284678 |
Oedema | 18.10 | 9.84 | 206 | 213605 | 91729 | 64193192 |
Muscle tightness | 18.10 | 9.84 | 79 | 213732 | 11036 | 64273885 |
Dysphemia | 18.02 | 9.84 | 35 | 213776 | 3084 | 64281837 |
Cataract | 18.00 | 9.84 | 98 | 213713 | 51164 | 64233757 |
Pulmonary alveolar haemorrhage | 17.96 | 9.84 | 5 | 213806 | 9733 | 64275188 |
Drug level above therapeutic | 17.92 | 9.84 | 57 | 213754 | 6844 | 64278077 |
Menopause | 17.79 | 9.84 | 25 | 213786 | 1683 | 64283238 |
Graft versus host disease | 17.72 | 9.84 | 12 | 213799 | 13801 | 64271120 |
Fibromyalgia | 17.65 | 9.84 | 60 | 213751 | 35671 | 64249250 |
Subclavian artery thrombosis | 17.63 | 9.84 | 6 | 213805 | 30 | 64284891 |
Sputum purulent | 17.55 | 9.84 | 21 | 213790 | 1205 | 64283716 |
Dermatitis bullous | 17.55 | 9.84 | 9 | 213802 | 12045 | 64272876 |
Delusion | 17.54 | 9.84 | 111 | 213700 | 17903 | 64267018 |
Genital anaesthesia | 17.48 | 9.84 | 5 | 213806 | 12 | 64284909 |
Chronic spontaneous urticaria | 17.46 | 9.84 | 14 | 213797 | 489 | 64284432 |
Hypersexuality | 17.45 | 9.84 | 23 | 213788 | 1456 | 64283465 |
Speech disorder | 17.44 | 9.84 | 241 | 213570 | 48200 | 64236721 |
Cholangitis | 17.38 | 9.84 | 7 | 213804 | 10795 | 64274126 |
Kidney transplant rejection | 17.32 | 9.84 | 5 | 213806 | 9506 | 64275415 |
Semen volume decreased | 17.28 | 9.84 | 7 | 213804 | 61 | 64284860 |
Sexual relationship change | 17.20 | 9.84 | 5 | 213806 | 13 | 64284908 |
Vasoplegia syndrome | 17.16 | 9.84 | 32 | 213779 | 2735 | 64282186 |
Bacteraemia | 17.13 | 9.84 | 40 | 213771 | 26871 | 64258050 |
Hypersomnia | 17.08 | 9.84 | 118 | 213693 | 19599 | 64265322 |
Cystoid macular oedema | 17.06 | 9.84 | 25 | 213786 | 1749 | 64283172 |
Chronic kidney disease | 17.06 | 9.84 | 117 | 213694 | 57802 | 64227119 |
Right ventricular failure | 17.06 | 9.84 | 28 | 213783 | 21443 | 64263478 |
Cystitis haemorrhagic | 16.85 | 9.84 | 3 | 213808 | 7953 | 64276968 |
Bipolar disorder | 16.79 | 9.84 | 55 | 213756 | 6706 | 64278215 |
Oropharyngeal pain | 16.77 | 9.84 | 201 | 213610 | 88666 | 64196255 |
Localised infection | 16.77 | 9.84 | 48 | 213763 | 30113 | 64254808 |
Morbid thoughts | 16.72 | 9.84 | 16 | 213795 | 710 | 64284211 |
Injection site erythema | 16.68 | 9.84 | 152 | 213659 | 70648 | 64214273 |
Aplastic anaemia | 16.68 | 9.84 | 13 | 213798 | 13907 | 64271014 |
Condition aggravated | 16.65 | 9.84 | 1038 | 212773 | 371388 | 63913533 |
Electrolyte substitution therapy | 16.62 | 9.84 | 4 | 213807 | 3 | 64284918 |
Amputation stump pain | 16.58 | 9.84 | 6 | 213805 | 37 | 64284884 |
Sternal fracture | 16.53 | 9.84 | 28 | 213783 | 2219 | 64282702 |
CYP3A4 polymorphism | 16.44 | 9.84 | 7 | 213804 | 70 | 64284851 |
Red blood cell sedimentation rate increased | 16.43 | 9.84 | 51 | 213760 | 31184 | 64253737 |
Aspergillus infection | 16.43 | 9.84 | 18 | 213793 | 16361 | 64268560 |
Wrong technique in product usage process | 16.42 | 9.84 | 137 | 213674 | 64837 | 64220084 |
Legal problem | 16.30 | 9.84 | 9 | 213802 | 165 | 64284756 |
Atrophic vulvovaginitis | 16.26 | 9.84 | 20 | 213791 | 1181 | 64283740 |
Accidental poisoning | 16.24 | 9.84 | 22 | 213789 | 1431 | 64283490 |
Bronchitis | 16.21 | 9.84 | 258 | 213553 | 108485 | 64176436 |
Meningitis streptococcal | 16.21 | 9.84 | 9 | 213802 | 167 | 64284754 |
Upper respiratory fungal infection | 16.20 | 9.84 | 11 | 213800 | 296 | 64284625 |
Sexually inappropriate behaviour | 16.19 | 9.84 | 13 | 213798 | 455 | 64284466 |
Incontinence | 16.11 | 9.84 | 81 | 213730 | 12000 | 64272921 |
Hepatocellular carcinoma | 16.09 | 9.84 | 4 | 213807 | 8399 | 64276522 |
Hypoalbuminaemia | 16.05 | 9.84 | 21 | 213790 | 17653 | 64267268 |
Therapy interrupted | 16.04 | 9.84 | 26 | 213785 | 20010 | 64264911 |
Drug abuser | 16.03 | 9.84 | 49 | 213762 | 5759 | 64279162 |
CFTR gene mutation | 15.93 | 9.84 | 7 | 213804 | 76 | 64284845 |
Mood altered | 15.89 | 9.84 | 99 | 213712 | 15880 | 64269041 |
Tuberculosis | 15.85 | 9.84 | 12 | 213799 | 13026 | 64271895 |
Polymenorrhagia | 15.82 | 9.84 | 6 | 213805 | 43 | 64284878 |
Lung disorder | 15.79 | 9.84 | 127 | 213684 | 60573 | 64224348 |
Multiple sclerosis relapse | 15.78 | 9.84 | 207 | 213604 | 40928 | 64243993 |
Basal cell carcinoma | 15.77 | 9.84 | 51 | 213760 | 30787 | 64254134 |
Respiratory tract infection | 15.76 | 9.84 | 67 | 213744 | 37340 | 64247581 |
Post-traumatic neck syndrome | 15.74 | 9.84 | 25 | 213786 | 1877 | 64283044 |
Metastases to liver | 15.71 | 9.84 | 35 | 213776 | 23906 | 64261015 |
Cardiac steatosis | 15.70 | 9.84 | 6 | 213805 | 44 | 64284877 |
Coordination abnormal | 15.70 | 9.84 | 94 | 213717 | 14870 | 64270051 |
Pneumonia bacterial | 15.66 | 9.84 | 16 | 213795 | 15019 | 64269902 |
Basal ganglion degeneration | 15.55 | 9.84 | 12 | 213799 | 396 | 64284525 |
Meconium in amniotic fluid | 15.54 | 9.84 | 7 | 213804 | 81 | 64284840 |
Violence-related symptom | 15.41 | 9.84 | 15 | 213796 | 680 | 64284241 |
Asthma | 15.35 | 9.84 | 419 | 213392 | 94806 | 64190115 |
Lipoedema | 15.22 | 9.84 | 9 | 213802 | 189 | 64284732 |
Sensory disturbance | 15.18 | 9.84 | 85 | 213726 | 13123 | 64271798 |
Hypersensitivity | 15.17 | 9.84 | 516 | 213295 | 195936 | 64088985 |
Renal disorder | 15.12 | 9.84 | 63 | 213748 | 35302 | 64249619 |
Mucormycosis | 15.06 | 9.84 | 3 | 213808 | 7338 | 64277583 |
Blunted affect | 15.04 | 9.84 | 12 | 213799 | 416 | 64284505 |
Pulmonary oedema | 14.98 | 9.84 | 354 | 213457 | 78320 | 64206601 |
End stage renal disease | 14.98 | 9.84 | 8 | 213803 | 10467 | 64274454 |
Dermatillomania | 14.97 | 9.84 | 9 | 213802 | 195 | 64284726 |
Job dissatisfaction | 14.94 | 9.84 | 6 | 213805 | 51 | 64284870 |
Antipsychotic drug level increased | 14.92 | 9.84 | 44 | 213767 | 5071 | 64279850 |
Balance disorder | 14.89 | 9.84 | 374 | 213437 | 83552 | 64201369 |
Dysponesis | 14.83 | 9.84 | 4 | 213807 | 7 | 64284914 |
Soft tissue injury | 14.82 | 9.84 | 22 | 213789 | 1557 | 64283364 |
Adenovirus infection | 14.81 | 9.84 | 3 | 213808 | 7252 | 64277669 |
Throat irritation | 14.79 | 9.84 | 57 | 213754 | 32654 | 64252267 |
Proteinuria | 14.77 | 9.84 | 45 | 213766 | 27678 | 64257243 |
Vascular access site infection | 14.75 | 9.84 | 7 | 213804 | 92 | 64284829 |
Pulmonary toxicity | 14.70 | 9.84 | 5 | 213806 | 8556 | 64276365 |
Caesarean section | 14.62 | 9.84 | 75 | 213736 | 11199 | 64273722 |
Dysaesthesia | 14.60 | 9.84 | 43 | 213768 | 4952 | 64279969 |
Parkinson's disease | 14.59 | 9.84 | 22 | 213789 | 1579 | 64283342 |
Toxic skin eruption | 14.54 | 9.84 | 26 | 213785 | 19258 | 64265663 |
Heparin-induced thrombocytopenia | 14.48 | 9.84 | 5 | 213806 | 8474 | 64276447 |
Haemoglobin decreased | 14.45 | 9.84 | 515 | 213296 | 194548 | 64090373 |
Nystagmus | 14.43 | 9.84 | 64 | 213747 | 9004 | 64275917 |
Self-medication | 14.40 | 9.84 | 38 | 213773 | 4107 | 64280814 |
Polyhydramnios | 14.37 | 9.84 | 21 | 213790 | 1466 | 64283455 |
Organising pneumonia | 14.36 | 9.84 | 6 | 213805 | 9049 | 64275872 |
Gestational diabetes | 14.36 | 9.84 | 46 | 213765 | 5544 | 64279377 |
Ejection fraction decreased | 14.32 | 9.84 | 48 | 213763 | 28659 | 64256262 |
Bipolar I disorder | 14.28 | 9.84 | 23 | 213788 | 1748 | 64283173 |
Hypervigilance | 14.24 | 9.84 | 12 | 213799 | 450 | 64284471 |
Female orgasmic disorder | 14.22 | 9.84 | 5 | 213806 | 28 | 64284893 |
Gas poisoning | 14.14 | 9.84 | 3 | 213808 | 0 | 64284921 |
New daily persistent headache | 14.14 | 9.84 | 3 | 213808 | 0 | 64284921 |
Vertigo CNS origin | 14.08 | 9.84 | 5 | 213806 | 29 | 64284892 |
Hyperkinesia | 14.02 | 9.84 | 28 | 213783 | 2518 | 64282403 |
Posturing | 13.94 | 9.84 | 17 | 213794 | 995 | 64283926 |
Uterine enlargement | 13.94 | 9.84 | 15 | 213796 | 766 | 64284155 |
Hallucinations, mixed | 13.94 | 9.84 | 48 | 213763 | 6004 | 64278917 |
Multiple drug therapy | 13.89 | 9.84 | 26 | 213785 | 2228 | 64282693 |
Respiratory tract congestion | 13.88 | 9.84 | 20 | 213791 | 16145 | 64268776 |
Injection site reaction | 13.87 | 9.84 | 94 | 213717 | 46570 | 64238351 |
Feeling of despair | 13.85 | 9.84 | 28 | 213783 | 2540 | 64282381 |
Fear | 13.69 | 9.84 | 114 | 213697 | 20057 | 64264864 |
Acute graft versus host disease in skin | 13.65 | 9.84 | 3 | 213808 | 6852 | 64278069 |
Haemolysis | 13.62 | 9.84 | 10 | 213801 | 11029 | 64273892 |
Blood uric acid increased | 13.62 | 9.84 | 5 | 213806 | 8158 | 64276763 |
Self esteem decreased | 13.61 | 9.84 | 16 | 213795 | 901 | 64284020 |
Oliguria | 13.56 | 9.84 | 17 | 213794 | 14559 | 64270362 |
Hypervolaemia | 13.55 | 9.84 | 73 | 213738 | 38212 | 64246709 |
Acute stress disorder | 13.53 | 9.84 | 11 | 213800 | 392 | 64284529 |
Hepatocellular injury | 13.51 | 9.84 | 91 | 213720 | 45144 | 64239777 |
Vaginal haemorrhage | 13.49 | 9.84 | 110 | 213701 | 19234 | 64265687 |
Bladder cancer | 13.47 | 9.84 | 10 | 213801 | 10964 | 64273957 |
Injection site pruritus | 13.46 | 9.84 | 72 | 213739 | 37754 | 64247167 |
Musculoskeletal pain | 13.45 | 9.84 | 189 | 213622 | 81105 | 64203816 |
Ventricular tachycardia | 13.38 | 9.84 | 173 | 213638 | 34092 | 64250829 |
Maternal exposure during breast feeding | 13.37 | 9.84 | 24 | 213787 | 1992 | 64282929 |
Labelled drug-drug interaction issue | 13.31 | 9.84 | 11 | 213800 | 401 | 64284520 |
Adrenergic syndrome | 13.31 | 9.84 | 7 | 213804 | 116 | 64284805 |
Vertigo | 13.29 | 9.84 | 272 | 213539 | 58739 | 64226182 |
Neuroleptic malignant syndrome | 13.28 | 9.84 | 134 | 213677 | 24862 | 64260059 |
Coronary artery disease | 13.28 | 9.84 | 132 | 213679 | 60301 | 64224620 |
Productive cough | 13.27 | 9.84 | 167 | 213644 | 73036 | 64211885 |
Lymphoma | 13.25 | 9.84 | 16 | 213795 | 13925 | 64270996 |
Mutism | 13.21 | 9.84 | 24 | 213787 | 2010 | 64282911 |
Acute respiratory failure | 13.20 | 9.84 | 104 | 213707 | 49830 | 64235091 |
Trismus | 13.20 | 9.84 | 41 | 213770 | 4860 | 64280061 |
Therapeutic response decreased | 13.20 | 9.84 | 110 | 213701 | 52078 | 64232843 |
Movement disorder | 13.20 | 9.84 | 121 | 213690 | 21879 | 64263042 |
Saliva altered | 13.11 | 9.84 | 11 | 213800 | 410 | 64284511 |
Executive dysfunction | 13.10 | 9.84 | 9 | 213802 | 247 | 64284674 |
Hepatitis C virus test positive | 13.09 | 9.84 | 10 | 213801 | 325 | 64284596 |
Polyarthritis | 13.07 | 9.84 | 8 | 213803 | 9707 | 64275214 |
Metastases to lung | 12.99 | 9.84 | 19 | 213792 | 15245 | 64269676 |
Product storage error | 12.96 | 9.84 | 15 | 213796 | 13303 | 64271618 |
Injection site swelling | 12.95 | 9.84 | 82 | 213729 | 41271 | 64243650 |
Prostate cancer | 12.94 | 9.84 | 29 | 213782 | 19766 | 64265155 |
Agranulocytosis | 12.92 | 9.84 | 74 | 213737 | 38155 | 64246766 |
Blood catecholamines decreased | 12.88 | 9.84 | 4 | 213807 | 14 | 64284907 |
Haematospermia | 12.85 | 9.84 | 9 | 213802 | 255 | 64284666 |
Device related infection | 12.82 | 9.84 | 55 | 213756 | 30571 | 64254350 |
Osmotic demyelination syndrome | 12.80 | 9.84 | 18 | 213793 | 1213 | 64283708 |
Stoma site infection | 12.75 | 9.84 | 18 | 213793 | 1217 | 64283704 |
Cellulitis | 12.72 | 9.84 | 226 | 213585 | 93431 | 64191490 |
Pneumonia viral | 12.70 | 9.84 | 5 | 213806 | 7817 | 64277104 |
Exposure to allergen | 12.70 | 9.84 | 8 | 213803 | 189 | 64284732 |
Intervertebral disc disorder | 12.67 | 9.84 | 38 | 213773 | 4419 | 64280502 |
Drug level increased | 12.67 | 9.84 | 171 | 213640 | 34025 | 64250896 |
Respiratory depression | 12.61 | 9.84 | 126 | 213685 | 23317 | 64261604 |
Wrong patient received product | 12.57 | 9.84 | 34 | 213777 | 3728 | 64281193 |
Osmolar gap abnormal | 12.57 | 9.84 | 6 | 213805 | 80 | 64284841 |
Cholestasis | 12.55 | 9.84 | 92 | 213719 | 44780 | 64240141 |
Gastrointestinal mucosal exfoliation | 12.55 | 9.84 | 8 | 213803 | 193 | 64284728 |
Affect lability | 12.50 | 9.84 | 61 | 213750 | 8929 | 64275992 |
Sleep disorder | 12.41 | 9.84 | 272 | 213539 | 59437 | 64225484 |
Panniculitis | 12.38 | 9.84 | 7 | 213804 | 8872 | 64276049 |
Tobacco user | 12.37 | 9.84 | 13 | 213798 | 646 | 64284275 |
Anaphylactic shock | 12.37 | 9.84 | 55 | 213756 | 30273 | 64254648 |
Systolic hypertension | 12.35 | 9.84 | 13 | 213798 | 647 | 64284274 |
Ventricular arrhythmia | 12.30 | 9.84 | 53 | 213758 | 7362 | 64277559 |
Hypocoagulable state | 12.21 | 9.84 | 22 | 213789 | 1831 | 64283090 |
Antisocial behaviour | 12.20 | 9.84 | 12 | 213799 | 551 | 64284370 |
Hypoxia | 12.20 | 9.84 | 212 | 213599 | 87937 | 64196984 |
Paraesthesia | 12.18 | 9.84 | 554 | 213257 | 133968 | 64150953 |
Acute hepatic failure | 12.13 | 9.84 | 45 | 213766 | 26067 | 64258854 |
Electrocardiogram QT interval abnormal | 12.12 | 9.84 | 9 | 213802 | 280 | 64284641 |
Cushingoid | 12.12 | 9.84 | 5 | 213806 | 7598 | 64277323 |
Dysphoria | 12.09 | 9.84 | 37 | 213774 | 4351 | 64280570 |
Somatic symptom disorder | 12.08 | 9.84 | 22 | 213789 | 1846 | 64283075 |
Skin laceration | 12.07 | 9.84 | 129 | 213682 | 24288 | 64260633 |
Cervix haematoma uterine | 12.07 | 9.84 | 3 | 213808 | 3 | 64284918 |
Bisexuality | 12.07 | 9.84 | 3 | 213808 | 3 | 64284918 |
Antidepressant drug level below therapeutic | 12.07 | 9.84 | 3 | 213808 | 3 | 64284918 |
Azoospermia | 12.05 | 9.84 | 7 | 213804 | 142 | 64284779 |
Therapy cessation | 12.03 | 9.84 | 61 | 213750 | 32428 | 64252493 |
Cardiac tamponade | 12.03 | 9.84 | 6 | 213805 | 8158 | 64276763 |
Pleurisy | 12.02 | 9.84 | 8 | 213803 | 9283 | 64275638 |
Oesophageal perforation | 12.00 | 9.84 | 16 | 213795 | 1025 | 64283896 |
Hepatitis fulminant | 11.99 | 9.84 | 3 | 213808 | 6271 | 64278650 |
Drug dose titration not performed | 11.99 | 9.84 | 13 | 213798 | 670 | 64284251 |
Economic problem | 11.98 | 9.84 | 24 | 213787 | 2163 | 64282758 |
Marital problem | 11.86 | 9.84 | 8 | 213803 | 213 | 64284708 |
COVID-19 pneumonia | 11.78 | 9.84 | 23 | 213788 | 16481 | 64268440 |
Diffuse large B-cell lymphoma stage II | 11.76 | 9.84 | 6 | 213805 | 93 | 64284828 |
Metastases to bone | 11.75 | 9.84 | 32 | 213779 | 20403 | 64264518 |
Facial paralysis | 11.73 | 9.84 | 105 | 213706 | 18861 | 64266060 |
Tissue infiltration | 11.67 | 9.84 | 12 | 213799 | 581 | 64284340 |
Male orgasmic disorder | 11.65 | 9.84 | 5 | 213806 | 51 | 64284870 |
Pain | 11.63 | 9.84 | 1633 | 212178 | 551878 | 63733043 |
Feeling guilty | 11.62 | 9.84 | 14 | 213797 | 809 | 64284112 |
JC virus CSF test positive | 11.59 | 9.84 | 7 | 213804 | 153 | 64284768 |
Anaphylactic reaction | 11.59 | 9.84 | 159 | 213652 | 68505 | 64216416 |
Adjusted calcium increased | 11.57 | 9.84 | 5 | 213806 | 52 | 64284869 |
Myositis | 11.54 | 9.84 | 23 | 213788 | 16354 | 64268567 |
Pyelonephritis | 11.53 | 9.84 | 25 | 213786 | 17241 | 64267680 |
Hypertension | 11.50 | 9.84 | 723 | 213088 | 258538 | 64026383 |
Blood osmolarity decreased | 11.48 | 9.84 | 17 | 213794 | 1201 | 64283720 |
Shock haemorrhagic | 11.47 | 9.84 | 24 | 213787 | 16767 | 64268154 |
Adjustment disorder | 11.47 | 9.84 | 27 | 213784 | 2718 | 64282203 |
Unintentional medical device removal | 11.45 | 9.84 | 4 | 213807 | 6730 | 64278191 |
Osteoporosis | 11.43 | 9.84 | 87 | 213724 | 41993 | 64242928 |
Thirst | 11.31 | 9.84 | 83 | 213728 | 14054 | 64270867 |
Differential white blood cell count abnormal | 11.31 | 9.84 | 21 | 213790 | 1789 | 64283132 |
Amniorrhexis | 11.29 | 9.84 | 4 | 213807 | 23 | 64284898 |
Detoxification | 11.27 | 9.84 | 6 | 213805 | 102 | 64284819 |
Pemphigoid | 11.21 | 9.84 | 16 | 213795 | 12970 | 64271951 |
Accommodation disorder | 11.18 | 9.84 | 11 | 213800 | 505 | 64284416 |
Bipolar II disorder | 11.18 | 9.84 | 9 | 213802 | 316 | 64284605 |
Clostridium difficile infection | 11.18 | 9.84 | 72 | 213739 | 36091 | 64248830 |
Pain in extremity | 11.17 | 9.84 | 859 | 212952 | 302226 | 63982695 |
Nephropathy | 11.15 | 9.84 | 7 | 213804 | 8379 | 64276542 |
Peripheral ischaemia | 11.13 | 9.84 | 7 | 213804 | 8371 | 64276550 |
Musculoskeletal stiffness | 11.11 | 9.84 | 317 | 213494 | 122889 | 64162032 |
Social problem | 11.07 | 9.84 | 17 | 213794 | 1240 | 64283681 |
Hepatic steatosis | 11.05 | 9.84 | 154 | 213657 | 30853 | 64254068 |
Decreased appetite | 11.04 | 9.84 | 793 | 213018 | 280496 | 64004425 |
Poor personal hygiene | 11.02 | 9.84 | 11 | 213800 | 514 | 64284407 |
Hypoxic-ischaemic encephalopathy | 11.02 | 9.84 | 50 | 213761 | 7102 | 64277819 |
Neurotoxicity | 10.99 | 9.84 | 50 | 213761 | 27354 | 64257567 |
Peritoneal perforation | 10.98 | 9.84 | 7 | 213804 | 169 | 64284752 |
Product administration error | 10.98 | 9.84 | 140 | 213671 | 27503 | 64257418 |
Therapy non-responder | 10.98 | 9.84 | 153 | 213658 | 65746 | 64219175 |
Spermatozoa progressive motility decreased | 10.94 | 9.84 | 5 | 213806 | 60 | 64284861 |
Sebaceous gland infection | 10.87 | 9.84 | 6 | 213805 | 110 | 64284811 |
Alcoholic psychosis | 10.86 | 9.84 | 3 | 213808 | 6 | 64284915 |
Leukopenia | 10.86 | 9.84 | 254 | 213557 | 100988 | 64183933 |
Pelvic fracture | 10.85 | 9.84 | 66 | 213745 | 10497 | 64274424 |
Slow response to stimuli | 10.85 | 9.84 | 19 | 213792 | 1546 | 64283375 |
Testicular atrophy | 10.78 | 9.84 | 9 | 213802 | 333 | 64284588 |
Joint ankylosis | 10.73 | 9.84 | 13 | 213798 | 756 | 64284165 |
Infective pulmonary exacerbation of cystic fibrosis | 10.73 | 9.84 | 14 | 213797 | 11782 | 64273139 |
Body dysmorphic disorder | 10.71 | 9.84 | 8 | 213803 | 251 | 64284670 |
Coronary artery bypass | 10.70 | 9.84 | 3 | 213808 | 5812 | 64279109 |
Swollen tongue | 10.66 | 9.84 | 169 | 213642 | 34785 | 64250136 |
Persistent depressive disorder | 10.66 | 9.84 | 15 | 213796 | 1011 | 64283910 |
Atrial flutter | 10.66 | 9.84 | 31 | 213780 | 19349 | 64265572 |
Blood ethanol increased | 10.64 | 9.84 | 12 | 213799 | 646 | 64284275 |
Hypoglycaemia | 10.63 | 9.84 | 381 | 213430 | 89511 | 64195410 |
Stiff person syndrome | 10.63 | 9.84 | 8 | 213803 | 254 | 64284667 |
Product substitution issue | 10.59 | 9.84 | 98 | 213713 | 17763 | 64267158 |
Eye haematoma | 10.59 | 9.84 | 6 | 213805 | 116 | 64284805 |
Feeling abnormal | 10.57 | 9.84 | 543 | 213268 | 133059 | 64151862 |
Therapy partial responder | 10.57 | 9.84 | 11 | 213800 | 10237 | 64274684 |
Pneumothorax | 10.56 | 9.84 | 43 | 213768 | 24255 | 64260666 |
Orthostatic intolerance | 10.55 | 9.84 | 19 | 213792 | 1581 | 64283340 |
Jaundice cholestatic | 10.51 | 9.84 | 8 | 213803 | 8662 | 64276259 |
Akinesia | 10.46 | 9.84 | 28 | 213783 | 3051 | 64281870 |
Surgery | 10.43 | 9.84 | 53 | 213758 | 28160 | 64256761 |
Infected dermal cyst | 10.42 | 9.84 | 13 | 213798 | 779 | 64284142 |
Ocular hyperaemia | 10.40 | 9.84 | 39 | 213772 | 22525 | 64262396 |
Nephropathy toxic | 10.39 | 9.84 | 27 | 213784 | 17487 | 64267434 |
Carbon monoxide poisoning | 10.37 | 9.84 | 8 | 213803 | 264 | 64284657 |
Vaginal discharge | 10.36 | 9.84 | 33 | 213778 | 3964 | 64280957 |
Agonal rhythm | 10.32 | 9.84 | 5 | 213806 | 69 | 64284852 |
Blood urea increased | 10.31 | 9.84 | 95 | 213716 | 44058 | 64240863 |
Bone erosion | 10.30 | 9.84 | 14 | 213797 | 11581 | 64273340 |
Post-traumatic stress disorder | 10.26 | 9.84 | 34 | 213777 | 4171 | 64280750 |
Tricuspid valve incompetence | 10.25 | 9.84 | 26 | 213785 | 16977 | 64267944 |
Extensor plantar response | 10.21 | 9.84 | 19 | 213792 | 1621 | 64283300 |
Gastrointestinal disorder | 10.21 | 9.84 | 223 | 213588 | 89486 | 64195435 |
Reflexes abnormal | 10.19 | 9.84 | 13 | 213798 | 797 | 64284124 |
Epilepsy | 10.18 | 9.84 | 162 | 213649 | 33369 | 64251552 |
Hypokalaemia | 10.17 | 9.84 | 498 | 213313 | 121405 | 64163516 |
Blood lactate dehydrogenase increased | 10.15 | 9.84 | 66 | 213745 | 33012 | 64251909 |
Cardiac failure chronic | 10.15 | 9.84 | 9 | 213802 | 9032 | 64275889 |
Diabetes mellitus | 10.14 | 9.84 | 157 | 213654 | 66317 | 64218604 |
Miosis | 10.11 | 9.84 | 77 | 213734 | 13189 | 64271732 |
Inguinal mass | 10.10 | 9.84 | 7 | 213804 | 195 | 64284726 |
Feeling of body temperature change | 10.07 | 9.84 | 37 | 213774 | 4777 | 64280144 |
Thrombotic stroke | 10.02 | 9.84 | 12 | 213799 | 689 | 64284232 |
Potentiating drug interaction | 10.02 | 9.84 | 52 | 213759 | 7800 | 64277121 |
Borderline personality disorder | 10.01 | 9.84 | 13 | 213798 | 811 | 64284110 |
Schizoaffective disorder depressive type | 10.01 | 9.84 | 3 | 213808 | 9 | 64284912 |
Genito-pelvic pain/penetration disorder | 10.01 | 9.84 | 3 | 213808 | 9 | 64284912 |
Angiodermatitis | 10.01 | 9.84 | 5 | 213806 | 74 | 64284847 |
Unevaluable event | 9.99 | 9.84 | 113 | 213698 | 50376 | 64234545 |
Injection site bruising | 9.97 | 9.84 | 75 | 213736 | 36298 | 64248623 |
Phobia | 9.88 | 9.84 | 9 | 213802 | 375 | 64284546 |
Heterophoria | 9.86 | 9.84 | 4 | 213807 | 35 | 64284886 |
Psychogenic seizure | 9.84 | 9.84 | 20 | 213791 | 1821 | 64283100 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Cryptorchism | 33.71 | 29.95 | 38 | 1407 | 371 | 82862 |
Respiratory disorder neonatal | 31.87 | 29.95 | 78 | 1367 | 1529 | 81704 |
Source | Code | Description |
---|---|---|
ATC | N06AB04 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Selective serotonin reuptake inhibitors |
FDA MoA | N0000000109 | Serotonin Uptake Inhibitors |
CHEBI has role | CHEBI:35469 | antidepressants |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:50949 | SSRI |
CHEBI has role | CHEBI:76779 | post-proline endopeptidase inhibitors |
CHEBI has role | CHEBI:77402 | EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitors |
CHEBI has role | CHEBI:78298 | environmental contaminants |
FDA EPC | N0000175696 | Serotonin Reuptake Inhibitor |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D018687 | Antidepressive Agents, Second-Generation |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D018490 | Serotonin Agents |
MeSH PA | D017367 | Serotonin Uptake Inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Generalized anxiety disorder | indication | 21897009 | DOID:14320 |
Depressive disorder | indication | 35489007 | |
Major depressive disorder | indication | 370143000 | |
Posttraumatic stress disorder | off-label use | 47505003 | DOID:2055 |
Bipolar affective disorder, current episode depression | off-label use | 191627008 | DOID:3312 |
Obsessive-compulsive disorder | off-label use | 191736004 | DOID:10933 |
Menopausal flushing | off-label use | 198436008 | |
Panic disorder | off-label use | 371631005 | DOID:594 |
Suicidal thoughts | contraindication | 6471006 | |
Bipolar disorder | contraindication | 13746004 | DOID:3312 |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Torsades de pointes | contraindication | 31722008 | |
Upper gastrointestinal hemorrhage | contraindication | 37372002 | |
Hypokalemia | contraindication | 43339004 | |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Heart disease | contraindication | 56265001 | DOID:114 |
Acute nephropathy | contraindication | 58574008 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Hyponatremia | contraindication | 89627008 | |
Prolonged QT interval | contraindication | 111975006 | |
Hypomagnesemia | contraindication | 190855004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Serotonin syndrome | contraindication | 371089000 | |
Myocardial infarction in recovery phase | contraindication | 418044006 | |
Poor metabolizer due to cytochrome p450 CYP2C19 variant | contraindication | 424500005 | |
Congenital long QT syndrome | contraindication | 442917000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.33 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Kd | 8.94 | WOMBAT-PK | CHEMBL | |||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.78 | DRUG MATRIX | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.40 | WOMBAT-PK | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.21 | CHEMBL | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 5.19 | PDSP | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 5.93 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 6.21 | WOMBAT-PK | |||||
Histamine H1 receptor | GPCR | Ki | 6.46 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 5.88 | PDSP | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 4.78 | CHEMBL | |||||
Alpha-1D adrenergic receptor | GPCR | Ki | 6.15 | DRUG MATRIX | |||||
Acetylcholinesterase | Enzyme | IC50 | 4.13 | CHEMBL | |||||
Solute carrier family 22 member 1 | Transporter | IC50 | 4.73 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 8.54 | CHEMBL | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 5.74 | DRUG MATRIX | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 5.76 | CHEMBL | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 4.30 | CHEMBL | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 8.82 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 5.03 | CHEMBL | |||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.54 | CHEMBL | |||||
Transporter | Transporter | Ki | 5.23 | CHEMBL | |||||
Transporter | Transporter | Ki | 5.21 | CHEMBL | |||||
Sigma intracellular receptor 2 | Unclassified | Ki | 5.27 | CHEMBL |
ID | Source |
---|---|
4021129 | VUID |
N0000148583 | NUI |
D00822 | KEGG_DRUG |
59729-32-7 | SECONDARY_CAS_RN |
221078 | RXNORM |
4021129 | VANDF |
4021130 | VANDF |
C0008845 | UMLSCUI |
CHEBI:3723 | CHEBI |
CHEMBL549 | ChEMBL_ID |
CHEMBL399730 | ChEMBL_ID |
DB00215 | DRUGBANK_ID |
CHEMBL1200781 | ChEMBL_ID |
D015283 | MESH_DESCRIPTOR_UI |
2771 | PUBCHEM_CID |
7547 | IUPHAR_LIGAND_ID |
4138 | INN_ID |
0DHU5B8D6V | UNII |
21814 | MMSL |
62559 | MMSL |
7486 | MMSL |
d04332 | MMSL |
005106 | NDDF |
005107 | NDDF |
116521005 | SNOMEDCT_US |
321986007 | SNOMEDCT_US |
372596005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0062 | SOLUTION | 10 mg | ORAL | ANDA | 27 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0848 | SOLUTION | 10 mg | ORAL | ANDA | 32 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-1696 | SOLUTION | 20 mg | ORAL | ANDA | 32 sections |
Citalopram | Human Prescription Drug Label | 1 | 0185-0371 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
Citalopram | Human Prescription Drug Label | 1 | 0185-0372 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 31 sections |
Citalopram | Human Prescription Drug Label | 1 | 0185-0373 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 31 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-6231 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 39 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-6231 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 39 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-6232 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 39 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-6232 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 39 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-6233 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 39 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-6233 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 39 sections |
Celexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-4010 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 35 sections |
Celexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-4010 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 35 sections |
Celexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-4020 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 35 sections |
Celexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-4020 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 35 sections |
Celexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-4040 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 35 sections |
Celexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-4040 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 35 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8022 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8023 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 31 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8141 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 31 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-4740 | TABLET | 10 mg | ORAL | ANDA | 19 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-4741 | TABLET | 20 mg | ORAL | ANDA | 19 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-4742 | TABLET | 40 mg | ORAL | ANDA | 19 sections |
Citalopram Hydrobromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6084 | TABLET | 10 mg | ORAL | ANDA | 25 sections |
Citalopram Hydrobromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6085 | TABLET | 20 mg | ORAL | ANDA | 25 sections |
Citalopram Hydrobromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6086 | TABLET | 40 mg | ORAL | ANDA | 25 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-006 | TABLET | 20 mg | ORAL | ANDA | 32 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-149 | TABLET | 20 mg | ORAL | ANDA | 34 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-150 | TABLET | 40 mg | ORAL | ANDA | 34 sections |