citalopram 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
663 59729-33-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • citalopram
  • nitalapram
  • bonitrile
  • citalopram hydrobromide
A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.
  • Molecular weight: 324.40
  • Formula: C20H21FN2O
  • CLOGP: 3.13
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 36.26
  • ALOGS: -4.74
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O
20 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.03 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 12 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.64 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 12 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.20 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 33 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 17, 1998 FDA FOREST LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1408.42 9.54 1977 193726 143696 63149623
Toxicity to various agents 1232.52 9.54 2494 193209 244756 63048563
Drug abuse 1066.27 9.54 1214 194489 71304 63222015
Electrocardiogram QT prolonged 687.47 9.54 882 194821 58648 63234671
Serotonin syndrome 598.14 9.54 579 195124 28103 63265216
Overdose 523.94 9.54 1120 194583 113958 63179361
Drug interaction 523.41 9.54 1724 193979 227407 63065912
Pemphigus 508.87 9.54 12 195691 183714 63109605
Systemic lupus erythematosus 464.56 9.54 51 195652 208867 63084452
Intentional overdose 460.83 9.54 823 194880 73329 63219990
Hand deformity 459.69 9.54 6 195697 159451 63133868
Synovitis 446.70 9.54 34 195669 186884 63106435
Suicide attempt 400.33 9.54 693 195010 60225 63233094
Drug ineffective 389.25 9.54 1782 193921 1042983 62250336
Glossodynia 356.70 9.54 61 195642 178815 63114504
Sopor 352.72 9.54 387 195316 21777 63271542
Anti-cyclic citrullinated peptide antibody positive 332.18 9.54 5 195698 116207 63177112
Suicidal ideation 330.57 9.54 647 195056 61774 63231545
Agitation 307.51 9.54 612 195091 59145 63234174
Arthropathy 299.65 9.54 176 195527 234616 63058703
Pericarditis 295.24 9.54 31 195672 131548 63161771
Drug intolerance 293.74 9.54 311 195392 308350 62984969
Alopecia 290.09 9.54 369 195334 337167 62956152
Hyponatraemia 289.86 9.54 880 194823 111020 63182299
Treatment failure 288.70 9.54 126 195577 198917 63094402
Torsade de pointes 271.69 9.54 266 195437 13085 63280234
Intentional self-injury 257.02 9.54 355 195348 25332 63267987
Wound 251.97 9.54 94 195609 163169 63130150
Helicobacter infection 249.59 9.54 8 195695 92777 63200542
Temperature regulation disorder 249.16 9.54 182 195521 5950 63287369
Duodenal ulcer perforation 240.18 9.54 6 195697 87203 63206116
Rheumatoid factor positive 235.59 9.54 5 195698 84401 63208918
Therapeutic product effect decreased 235.08 9.54 153 195550 193034 63100285
Respiratory arrest 228.42 9.54 382 195321 32263 63261056
Infusion related reaction 228.34 9.54 252 195451 245269 63048050
Anxiety 220.33 9.54 1282 194421 216259 63077060
Cardio-respiratory arrest 215.59 9.54 532 195171 59427 63233892
Tremor 210.08 9.54 886 194817 131353 63161966
Discomfort 207.11 9.54 130 195573 167244 63126075
Poisoning 198.78 9.54 228 195475 13472 63279847
Abdominal discomfort 194.29 9.54 439 195264 320446 62972873
Contraindicated product administered 194.10 9.54 231 195472 217417 63075902
Hyperhidrosis 186.66 9.54 742 194961 107094 63186225
Off label use 181.29 9.54 1277 194426 673185 62620134
Joint swelling 175.15 9.54 478 195225 327188 62966131
Muscle injury 174.44 9.54 6 195697 65339 63227980
Rash 170.36 9.54 1023 194680 559848 62733471
Swelling 167.25 9.54 376 195327 275002 63018317
Folliculitis 164.50 9.54 14 195689 70303 63223016
Food allergy 159.14 9.54 186 195517 11215 63282104
Somnolence 158.65 9.54 1018 194685 177667 63115652
Panic attack 158.47 9.54 263 195440 22068 63271251
Cardiac arrest 157.11 9.54 633 195070 91912 63201407
Infection 147.35 9.54 303 195400 228870 63064449
Sleep disorder due to general medical condition, insomnia type 146.07 9.54 3 195700 52214 63241105
Foetal exposure during pregnancy 137.16 9.54 304 195399 31658 63261661
Fall 137.13 9.54 1827 193876 390507 62902812
Disturbance in attention 129.03 9.54 331 195372 37858 63255461
Maternal exposure during pregnancy 128.30 9.54 307 195396 219755 63073564
Coeliac disease 128.21 9.54 177 195526 12620 63280699
Accidental overdose 123.80 9.54 242 195461 23067 63270252
Blister 121.94 9.54 132 195571 129682 63163637
Seizure 121.60 9.54 762 194941 131872 63161447
Depression 120.91 9.54 1026 194677 195466 63097853
Impaired healing 120.91 9.54 84 195619 102458 63190861
Myoclonus 119.52 9.54 192 195511 15676 63277643
Irritable bowel syndrome 118.08 9.54 53 195650 82359 63210960
Akathisia 117.43 9.54 143 195560 9003 63284316
Product use issue 116.74 9.54 323 195380 220197 63073122
Mydriasis 116.24 9.54 163 195540 11793 63281526
Irritability 115.78 9.54 283 195420 31411 63261908
Electrocardiogram QRS complex prolonged 112.84 9.54 114 195589 5824 63287495
Restlessness 110.81 9.54 266 195437 29187 63264132
Withdrawal syndrome 107.89 9.54 209 195494 19788 63273531
Unresponsive to stimuli 106.99 9.54 286 195417 33530 63259789
Bruxism 106.95 9.54 88 195615 3437 63289882
Drug withdrawal syndrome 102.74 9.54 246 195457 26948 63266371
Ill-defined disorder 96.34 9.54 67 195636 81688 63211631
Nightmare 95.59 9.54 194 195509 19000 63274319
Peripheral swelling 94.31 9.54 460 195243 265482 63027837
Immunodeficiency 94.17 9.54 199 195504 20055 63273264
Anorgasmia 93.94 9.54 43 195660 560 63292759
Aggression 92.49 9.54 216 195487 23282 63270037
Small for dates baby 92.18 9.54 83 195620 3668 63289651
Loss of consciousness 92.17 9.54 652 195051 117469 63175850
Stomatitis 92.02 9.54 180 195523 138545 63154774
Sinusitis 91.84 9.54 373 195330 226280 63067039
Hepatic enzyme increased 90.37 9.54 320 195383 202008 63091311
Long QT syndrome 89.47 9.54 77 195626 3202 63290117
Psoriatic arthropathy 89.38 9.54 90 195613 91430 63201889
Muscle twitching 86.57 9.54 189 195514 19479 63273840
Accidental death 85.65 9.54 61 195642 1915 63291404
Rheumatic fever 85.20 9.54 15 195688 43096 63250223
C-reactive protein increased 82.77 9.54 102 195601 94605 63198714
Febrile neutropenia 82.69 9.54 149 195554 118300 63175019
Muscle rigidity 81.00 9.54 135 195568 11365 63281954
Galactorrhoea 77.55 9.54 79 195624 4076 63289243
Intentional product use issue 75.61 9.54 177 195526 127715 63165604
Rash erythematous 75.50 9.54 295 195408 42215 63251104
Hallucination 75.39 9.54 352 195351 54465 63238854
Blood cholesterol increased 73.36 9.54 110 195593 93922 63199397
Intentional product misuse 72.94 9.54 376 195327 60541 63232778
Exposure via ingestion 72.73 9.54 65 195638 2844 63290475
Arthralgia 72.55 9.54 1278 194425 568432 62724887
Fibromyalgia 71.98 9.54 85 195618 80335 63212984
C-reactive protein abnormal 70.29 9.54 27 195676 46069 63247250
Disorientation 69.43 9.54 273 195430 39179 63254140
Alcoholism 67.24 9.54 51 195652 1767 63291552
Respiratory disorder neonatal 67.17 9.54 44 195659 1201 63292118
Hyperreflexia 66.98 9.54 87 195616 5847 63287472
Mania 66.40 9.54 129 195574 12238 63281081
Hip arthroplasty 66.14 9.54 32 195671 47614 63245705
Dyskinesia 64.25 9.54 231 195472 31771 63261548
Dizziness 63.37 9.54 1754 193949 428171 62865148
Haematemesis 63.17 9.54 222 195481 30190 63263129
Extrapyramidal disorder 62.31 9.54 131 195572 13153 63280166
Self-injurious ideation 61.75 9.54 57 195646 2602 63290717
Confusional state 61.45 9.54 1047 194656 235333 63057986
Memory impairment 61.22 9.54 539 195164 103719 63189600
Pain 60.39 9.54 1781 193922 738847 62554472
Product prescribing error 59.96 9.54 198 195505 26091 63267228
Knee arthroplasty 59.25 9.54 48 195655 54158 63239161
Depressed level of consciousness 57.68 9.54 358 195345 61720 63231599
Malignant neoplasm progression 57.58 9.54 103 195600 82018 63211301
Psychomotor hyperactivity 56.97 9.54 111 195592 10552 63282767
Hypersensitivity 56.87 9.54 602 195101 292083 63001236
Depressed mood 55.94 9.54 259 195444 39932 63253387
Coma scale abnormal 55.76 9.54 74 195629 5079 63288240
Yawning 55.44 9.54 37 195666 1043 63292276
Crying 55.21 9.54 178 195525 23165 63270154
Interstitial lung disease 54.80 9.54 66 195637 61842 63231477
Labelled drug-drug interaction issue 54.79 9.54 37 195666 1064 63292255
Bradycardia 54.67 9.54 400 195303 72827 63220492
Generalised tonic-clonic seizure 53.68 9.54 204 195499 28812 63264507
Bradyphrenia 53.31 9.54 85 195618 6895 63286424
Myocardial stunning 53.02 9.54 20 195683 153 63293166
Obsessive-compulsive disorder 52.97 9.54 64 195639 3996 63289323
Parkinsonism 52.56 9.54 106 195597 10333 63282986
Ventricular septal defect 52.27 9.54 66 195637 4312 63289007
Inappropriate antidiuretic hormone secretion 51.17 9.54 133 195570 15329 63277990
Neonatal hypoxia 51.13 9.54 29 195674 606 63292713
Antidepressant drug level above therapeutic 49.37 9.54 25 195678 412 63292907
Ventricular tachycardia 48.75 9.54 154 195549 19825 63273494
Therapeutic product effect incomplete 48.62 9.54 209 195494 124847 63168472
Nasopharyngitis 48.56 9.54 525 195178 253732 63039587
Pyrexia 48.46 9.54 1093 194610 469385 62823934
Loss of libido 48.04 9.54 37 195666 1312 63292007
Syncope 47.39 9.54 562 195141 116823 63176496
Pulseless electrical activity 47.33 9.54 84 195619 7437 63285882
Lethargy 47.12 9.54 315 195388 55692 63237627
Neutropenia 46.40 9.54 332 195371 174673 63118646
Product use in unapproved indication 46.39 9.54 342 195361 178738 63114581
Musculoskeletal stiffness 46.20 9.54 356 195347 184262 63109057
Psychotic disorder 46.11 9.54 179 195524 25533 63267786
Disease progression 46.00 9.54 208 195495 122550 63170769
Illness anxiety disorder 45.65 9.54 17 195686 125 63293194
Pancytopenia 45.48 9.54 150 195553 96783 63196536
Macular degeneration 44.98 9.54 10 195693 24366 63268953
Atrial septal defect 44.32 9.54 78 195625 6860 63286459
Anger 44.19 9.54 110 195593 12346 63280973
Medication error 43.95 9.54 294 195409 51990 63241329
Hyperprolactinaemia 43.74 9.54 57 195646 3843 63289476
Bradykinesia 43.56 9.54 66 195637 5122 63288197
Drug withdrawal syndrome neonatal 43.34 9.54 42 195661 2039 63291280
Mood swings 43.02 9.54 139 195564 18109 63275210
Condition aggravated 42.95 9.54 929 194774 401288 62892031
Lower respiratory tract infection 42.81 9.54 236 195467 132071 63161248
Nicotine dependence 42.79 9.54 27 195676 690 63292629
Pneumonia 42.65 9.54 1077 194626 455690 62837629
Bursitis 42.52 9.54 226 195477 36815 63256504
Alcohol abuse 42.25 9.54 42 195661 2104 63291215
Mobility decreased 42.06 9.54 211 195492 120948 63172371
Drug dependence 41.93 9.54 168 195535 24315 63269004
Reversible cerebral vasoconstriction syndrome 41.56 9.54 46 195657 2612 63290707
Myelosuppression 41.25 9.54 11 195692 23692 63269627
Septic shock 41.16 9.54 90 195613 66539 63226780
Impulsive behaviour 40.83 9.54 36 195667 1547 63291772
Abnormal behaviour 40.76 9.54 152 195551 21274 63272045
Rib deformity 40.67 9.54 19 195684 260 63293059
Posturing 40.62 9.54 23 195680 479 63292840
Hypoglycaemia 40.29 9.54 320 195383 59745 63233574
Ventricular arrhythmia 39.93 9.54 54 195649 3774 63289545
Obsessive thoughts 39.70 9.54 24 195679 567 63292752
Concussion 38.61 9.54 87 195616 9157 63284162
Cerebral vasoconstriction 38.42 9.54 31 195672 1177 63292142
Libido decreased 37.97 9.54 44 195659 2628 63290691
Thinking abnormal 37.77 9.54 94 195609 10549 63282770
Gastrointestinal disorder 37.75 9.54 243 195460 130996 63162323
Abnormal dreams 37.44 9.54 93 195610 10423 63282896
Hypokinesia 37.34 9.54 111 195592 13825 63279494
Drug tolerance decreased 36.98 9.54 5 195698 17468 63275851
Calcium deficiency 36.31 9.54 29 195674 1085 63292234
Catatonia 36.24 9.54 56 195647 4421 63288898
Apathy 35.88 9.54 82 195621 8712 63284607
Angle closure glaucoma 35.73 9.54 39 195664 2180 63291139
Mucosal inflammation 35.53 9.54 56 195647 46872 63246447
Suicidal behaviour 35.08 9.54 42 195661 2597 63290722
Speech disorder 35.08 9.54 230 195473 40399 63252920
Insomnia 34.72 9.54 889 194814 214363 63078956
Hepatic function abnormal 34.59 9.54 38 195665 37104 63256215
Ductus arteriosus premature closure 34.43 9.54 18 195685 318 63293001
Liver disorder 34.43 9.54 71 195632 53616 63239703
Ventricular fibrillation 34.19 9.54 97 195606 11770 63281549
Cytomegalovirus infection 34.12 9.54 11 195692 20941 63272378
Hostility 33.86 9.54 35 195668 1837 63291482
Clonus 33.42 9.54 55 195648 4581 63288738
Congenital thrombocytopenia 33.10 9.54 11 195692 55 63293264
Coma 32.86 9.54 323 195380 64041 63229278
Alcohol use 32.54 9.54 36 195667 2043 63291276
Hallucination, auditory 32.35 9.54 100 195603 12724 63280595
Dystonia 32.34 9.54 105 195598 13714 63279605
Rabbit syndrome 31.80 9.54 17 195686 315 63293004
Premature delivery 31.64 9.54 28 195675 30253 63263066
Tenosynovitis 31.57 9.54 3 195700 13792 63279527
Hypokalaemia 31.52 9.54 472 195231 103332 63189987
Fluid retention 31.19 9.54 301 195402 59385 63233934
Carcinoid heart disease 31.18 9.54 9 195694 25 63293294
Tearfulness 31.05 9.54 50 195653 4089 63289230
Panic reaction 30.74 9.54 50 195653 4124 63289195
Dementia 30.63 9.54 127 195576 18667 63274652
Brain injury 30.22 9.54 67 195636 6976 63286343
Red blood cell sedimentation rate increased 30.08 9.54 56 195647 43926 63249393
Physical assault 30.03 9.54 24 195679 899 63292420
Adverse event 30.02 9.54 107 195596 67452 63225867
Negative thoughts 29.93 9.54 24 195679 903 63292416
Bipolar I disorder 29.93 9.54 33 195670 1866 63291453
Photosensitivity reaction 29.89 9.54 108 195595 14886 63278433
Injection site pain 29.84 9.54 256 195447 129544 63163775
Rheumatoid arthritis 29.80 9.54 577 195126 253242 63040077
Rheumatoid nodule 29.78 9.54 8 195695 17147 63276172
Labelled drug-drug interaction medication error 29.74 9.54 100 195603 13299 63280020
Arthritis 29.71 9.54 222 195481 115699 63177620
Flat affect 29.70 9.54 29 195674 1421 63291898
Mental disorder 29.65 9.54 158 195545 25761 63267558
Nervousness 29.62 9.54 180 195523 30799 63262520
Drug eruption 29.42 9.54 27 195676 28667 63264652
Cholecystitis chronic 29.18 9.54 84 195619 10277 63283042
Stiff person syndrome 29.02 9.54 16 195687 316 63293003
Amnesia 28.89 9.54 280 195423 55305 63238014
Sputum purulent 28.60 9.54 25 195678 1062 63292257
Homicidal ideation 28.58 9.54 31 195672 1721 63291598
Emotional distress 28.55 9.54 185 195518 32364 63260955
Maternal drugs affecting foetus 28.53 9.54 55 195648 5187 63288132
Type 2 diabetes mellitus 28.48 9.54 101 195602 63767 63229552
Restless legs syndrome 28.47 9.54 123 195580 18408 63274911
Paranoia 28.47 9.54 90 195613 11589 63281730
Orthostatic intolerance 28.46 9.54 26 195677 1171 63292148
Toxicologic test abnormal 28.39 9.54 21 195682 700 63292619
Alcohol poisoning 27.94 9.54 32 195671 1887 63291432
Potentiating drug interaction 27.86 9.54 49 195654 4307 63289012
Hypotonia 27.83 9.54 77 195626 9208 63284111
Therapy non-responder 27.60 9.54 130 195573 75771 63217548
Selective eating disorder 27.58 9.54 33 195670 2039 63291280
Skin ulcer 27.54 9.54 57 195646 42988 63250331
Hyperkinesia 27.53 9.54 30 195673 1674 63291645
Congenital pulmonary valve atresia 27.52 9.54 10 195693 68 63293251
Cognitive disorder 27.47 9.54 278 195425 55537 63237782
Poor feeding infant 27.40 9.54 16 195687 354 63292965
Secondary immunodeficiency 27.10 9.54 27 195676 1356 63291963
Tachycardia 26.99 9.54 513 195190 117643 63175676
Post viral fatigue syndrome 26.95 9.54 15 195688 302 63293017
Stress 26.84 9.54 321 195382 66846 63226473
Hypochloraemia 26.75 9.54 32 195671 1977 63291342
Drug resistance 26.73 9.54 19 195684 22914 63270405
Platelet count decreased 26.26 9.54 230 195473 115892 63177427
Histrionic personality disorder 26.15 9.54 9 195694 51 63293268
Pneumocystis jirovecii pneumonia 25.63 9.54 10 195693 16904 63276415
Palmar-plantar erythrodysaesthesia syndrome 25.63 9.54 20 195683 22995 63270324
Major depression 25.54 9.54 68 195635 7950 63285369
Disturbance in sexual arousal 25.52 9.54 11 195692 123 63293196
Polyhydramnios 25.17 9.54 33 195670 2238 63291081
Vertigo 25.17 9.54 289 195414 59598 63233721
Liver function test increased 24.98 9.54 39 195664 32772 63260547
Adrenal insufficiency 24.91 9.54 12 195691 17903 63275416
Sedation complication 24.85 9.54 6 195697 13816 63279503
Autoimmune disorder 24.67 9.54 11 195692 17166 63276153
Pupillary reflex impaired 24.66 9.54 31 195672 2016 63291303
Urinary retention 24.63 9.54 169 195534 30132 63263187
Gestational diabetes 24.55 9.54 69 195634 8327 63284992
Injection site reaction 24.49 9.54 95 195608 58429 63234890
Sinus tachycardia 24.48 9.54 143 195560 24125 63269194
Hallucination, visual 24.41 9.54 121 195582 19177 63274142
Dyspnoea 24.37 9.54 1733 193970 659580 62633739
Dissociation 24.32 9.54 37 195666 2882 63290437
Optic ischaemic neuropathy 24.21 9.54 24 195679 1198 63292121
Cystoid macular oedema 24.18 9.54 27 195676 1548 63291771
Foetal chromosome abnormality 24.11 9.54 7 195696 20 63293299
Libido increased 24.07 9.54 25 195678 1320 63291999
Constipation 23.69 9.54 882 194821 224061 63069258
Mutism 23.43 9.54 27 195676 1603 63291716
Dermatillomania 23.26 9.54 11 195692 155 63293164
Personality change 23.09 9.54 60 195643 6913 63286406
Hepatotoxicity 22.90 9.54 50 195653 36991 63256328
CFTR gene mutation 22.87 9.54 10 195693 116 63293203
Neuropathy, ataxia, retinitis pigmentosa syndrome 22.86 9.54 8 195695 48 63293271
Neuropathy peripheral 22.77 9.54 232 195471 113435 63179884
Product dose omission issue 22.75 9.54 549 195154 233764 63059555
Melaena 22.73 9.54 166 195537 30199 63263120
Foetal death 22.67 9.54 80 195623 10900 63282419
Hypocoagulable state 22.62 9.54 23 195680 1184 63292135
Pruritus 22.60 9.54 898 194805 360555 62932764
Goitre 22.59 9.54 54 195649 5907 63287412
Bronchomalacia 22.56 9.54 12 195691 220 63293099
Abnormal weight gain 22.50 9.54 28 195675 1802 63291517
Postmortem blood drug level increased 22.46 9.54 17 195686 587 63292732
Pruritus allergic 22.39 9.54 26 195677 1556 63291763
Cataract 22.38 9.54 95 195608 56958 63236361
Sebaceous gland infection 22.24 9.54 11 195692 172 63293147
Basal ganglion degeneration 22.16 9.54 15 195688 433 63292886
Dysarthria 22.12 9.54 215 195488 42496 63250823
Hypercholesterolaemia 21.96 9.54 20 195683 21314 63272005
Tachyphrenia 21.87 9.54 24 195679 1350 63291969
Infantile apnoea 21.80 9.54 21 195682 1012 63292307
Adrenergic syndrome 21.57 9.54 7 195696 32 63293287
Therapeutic response decreased 21.43 9.54 107 195596 61418 63231901
Talipes 21.28 9.54 25 195678 1515 63291804
Pulmonary fibrosis 21.26 9.54 58 195645 39751 63253568
Post-traumatic neck syndrome 21.25 9.54 29 195674 2045 63291274
Bone marrow failure 21.19 9.54 36 195667 29254 63264065
Diaphragmatic rupture 21.19 9.54 12 195691 250 63293069
Feeling abnormal 21.09 9.54 603 195100 147789 63145530
Neoplasm progression 21.05 9.54 51 195652 36377 63256942
Mental impairment 21.04 9.54 93 195610 14058 63279261
Red blood cell sedimentation rate abnormal 21.02 9.54 18 195685 19764 63273555
Depression suicidal 21 9.54 27 195676 1796 63291523
Hypoxic-ischaemic encephalopathy 20.95 9.54 43 195660 4244 63289075
Substance abuse 20.93 9.54 46 195657 4761 63288558
Vascular access site thrombosis 20.90 9.54 7 195696 36 63293283
Asthma 20.89 9.54 528 195175 127033 63166286
Hospitalisation 20.83 9.54 165 195538 84916 63208403
Respiratory disorder 20.82 9.54 57 195646 39025 63254294
Neonatal respiratory depression 20.79 9.54 8 195695 65 63293254
Thrombocytopenia 20.79 9.54 334 195369 150823 63142496
Alcohol interaction 20.73 9.54 31 195672 2378 63290941
Facial paralysis 20.66 9.54 92 195611 13949 63279370
Iris coloboma 20.29 9.54 7 195696 40 63293279
Acute myeloid leukaemia 20.26 9.54 14 195689 17133 63276186
Hypotonia neonatal 20.24 9.54 22 195681 1224 63292095
Activation syndrome 20.23 9.54 11 195692 211 63293108
Substance abuser 20.21 9.54 6 195697 19 63293300
Product administration error 20.07 9.54 128 195575 22269 63271050
Fear 20.05 9.54 99 195604 15667 63277652
Injection site erythema 20.04 9.54 162 195541 83012 63210307
Product substitution issue 20.02 9.54 100 195603 15896 63277423
Female sexual arousal disorder 20.00 9.54 7 195696 42 63293277
Joint range of motion decreased 19.86 9.54 44 195659 32384 63260935
Hypertonia 19.77 9.54 44 195659 4593 63288726
Epilepsy 19.71 9.54 147 195556 26918 63266401
Anticholinergic syndrome 19.57 9.54 30 195673 2352 63290967
Social problem 19.53 9.54 18 195685 820 63292499
Bradycardia neonatal 19.43 9.54 19 195684 933 63292386
Drug hypersensitivity 19.38 9.54 772 194931 309915 62983404
Pulmonary valve stenosis congenital 19.37 9.54 10 195693 172 63293147
CYP3A4 polymorphism 19.34 9.54 8 195695 80 63293239
Agonal rhythm 19.33 9.54 6 195697 23 63293296
Infected dermal cyst 19.29 9.54 14 195689 453 63292866
Cytokine release syndrome 19.28 9.54 10 195693 14304 63279015
Neuroleptic malignant syndrome 19.28 9.54 81 195622 11975 63281344
Orgasm abnormal 19.26 9.54 8 195695 81 63293238
Atonic urinary bladder 19.17 9.54 8 195695 82 63293237
Acquired epileptic aphasia 19.14 9.54 4 195699 0 63293319
Antidepressant drug level increased 19.11 9.54 12 195691 304 63293015
Haematotoxicity 19.11 9.54 3 195700 9373 63283946
Cardiac failure 19.09 9.54 179 195524 88963 63204356
Cerebrospinal fluid retention 19.00 9.54 8 195695 84 63293235
Neuroglycopenia 18.99 9.54 14 195689 464 63292855
Osmotic demyelination syndrome 18.97 9.54 16 195687 647 63292672
Self esteem decreased 18.76 9.54 16 195687 657 63292662
Gait inability 18.50 9.54 92 195611 52867 63240452
Panniculitis 18.50 9.54 6 195697 11379 63281940
Skin swelling 18.47 9.54 36 195667 3423 63289896
Caput succedaneum 18.46 9.54 5 195698 10 63293309
Liver injury 18.46 9.54 110 195593 60410 63232909
Lip swelling 18.43 9.54 161 195542 30902 63262417
Vascular access site infection 18.40 9.54 7 195696 55 63293264
Pregnancy 18.38 9.54 184 195519 36652 63256667
Social avoidant behaviour 18.33 9.54 33 195670 2955 63290364
Muscle tightness 18.29 9.54 79 195624 11821 63281498
Delirium 18.24 9.54 237 195466 50304 63243015
Respiratory tract infection 18.23 9.54 66 195637 41417 63251902
Multiple sclerosis relapse 18.20 9.54 229 195474 48249 63245070
Metastases to liver 18.09 9.54 28 195675 23611 63269708
Sternal fracture 17.97 9.54 28 195675 2226 63291093
Cardiac failure congestive 17.96 9.54 190 195513 92243 63201076
Hypersomnia 17.96 9.54 106 195597 17949 63275370
Amputation stump pain 17.89 9.54 6 195697 31 63293288
Head injury 17.85 9.54 145 195558 27251 63266068
Meningitis streptococcal 17.79 9.54 9 195694 148 63293171
Retinal coloboma 17.73 9.54 6 195697 32 63293287
Mood altered 17.64 9.54 91 195612 14652 63278667
Tissue infiltration 17.63 9.54 15 195688 614 63292705
Hypertonic bladder 17.55 9.54 36 195667 3552 63289767
Panic disorder 17.34 9.54 30 195673 2603 63290716
Areflexia 17.32 9.54 33 195670 3085 63290234
Cholecystectomy 17.28 9.54 72 195631 10605 63282714
Chronic sinusitis 17.26 9.54 9 195694 12834 63280485
Lipoedema 17.23 9.54 11 195692 287 63293032
Meconium in amniotic fluid 17.20 9.54 11 195692 288 63293031
Transplant rejection 16.96 9.54 6 195697 10774 63282545
Soft tissue injury 16.77 9.54 23 195680 1629 63291690
Cardiac steatosis 16.74 9.54 6 195697 39 63293280
Cushingoid 16.66 9.54 3 195700 8482 63284837
Bone erosion 16.64 9.54 18 195685 17699 63275620
Herpes zoster 16.64 9.54 168 195535 82294 63211025
Differential white blood cell count abnormal 16.63 9.54 16 195687 770 63292549
Aspartate aminotransferase increased 16.57 9.54 188 195515 90089 63203230
Pyelonephritis chronic 16.55 9.54 10 195693 236 63293083
Decerebrate posture 16.53 9.54 8 195695 119 63293200
Circulatory collapse 16.46 9.54 120 195583 21818 63271501
Fibrous histiocytoma 16.46 9.54 14 195689 573 63292746
Kinematic imbalances due to suboccipital strain 16.38 9.54 4 195699 4 63293315
Psychiatric symptom 16.34 9.54 44 195659 5179 63288140
Rhabdomyolysis 16.24 9.54 207 195496 43744 63249575
Frequent bowel movements 16.18 9.54 124 195579 22898 63270421
Pulmonary valve disease 16.14 9.54 5 195698 19 63293300
Psoriasis 16.07 9.54 366 195337 86591 63206728
Akinesia 15.90 9.54 22 195681 1571 63291748
Urethral haemorrhage 15.90 9.54 6 195697 46 63293273
Aspiration 15.89 9.54 71 195632 10780 63282539
Loss of personal independence in daily activities 15.81 9.54 208 195495 97082 63196237
Leukopenia 15.78 9.54 157 195546 77133 63216186
Hyporeflexia 15.76 9.54 24 195679 1871 63291448
Morbid thoughts 15.73 9.54 14 195689 609 63292710
Non-cardiogenic pulmonary oedema 15.69 9.54 15 195688 716 63292603
Sleep terror 15.68 9.54 29 195674 2651 63290668
Delusion 15.67 9.54 76 195627 11941 63281378
Postmortem blood drug level 15.63 9.54 8 195695 135 63293184
Polymenorrhagia 15.57 9.54 6 195697 49 63293270
Initial insomnia 15.52 9.54 48 195655 6109 63287210
Respiratory alkalosis 15.52 9.54 29 195674 2672 63290647
Adjustment disorder with depressed mood 15.52 9.54 6 195697 10198 63283121
Live birth 15.51 9.54 35 195668 25595 63267724
Hippocampal sclerosis 15.51 9.54 7 195696 88 63293231
Ocular hyperaemia 15.50 9.54 34 195669 25110 63268209
Suspected suicide 15.45 9.54 50 195653 6518 63286801
Hallucinations, mixed 15.43 9.54 41 195662 4788 63288531
Pulmonary toxicity 15.33 9.54 5 195698 9450 63283869
Hypercalcaemia 15.32 9.54 41 195662 28281 63265038
Mental status changes 15.27 9.54 188 195515 39411 63253908
Urticaria 15.13 9.54 392 195311 165410 63127909
Dysponesis 15.12 9.54 4 195699 7 63293312
Tardive dyskinesia 15.09 9.54 59 195644 8443 63284876
Metastases to bone 15.06 9.54 26 195677 20993 63272326
Female orgasmic disorder 14.97 9.54 6 195697 55 63293264
Enterocolitis 14.96 9.54 3 195700 7855 63285464
Uterine enlargement 14.95 9.54 19 195684 1249 63292070
Neutrophil count decreased 14.94 9.54 107 195596 56299 63237020
Bipolar II disorder 14.89 9.54 11 195692 366 63292953
Creatinine renal clearance decreased 14.84 9.54 17 195686 16291 63277028
Respiratory rate increased 14.80 9.54 82 195621 13566 63279753
Thrombotic microangiopathy 14.80 9.54 7 195696 10554 63282765
Accommodation disorder 14.78 9.54 11 195692 370 63292949
Injection site swelling 14.76 9.54 86 195617 47486 63245833
Upper respiratory tract infection 14.75 9.54 344 195359 81703 63211616
Vertigo CNS origin 14.73 9.54 5 195698 27 63293292
Bronchial hyperreactivity 14.66 9.54 22 195681 1693 63291626
Swollen tongue 14.65 9.54 168 195535 34632 63258687
Tension 14.53 9.54 31 195672 3144 63290175
Pancreatitis 14.47 9.54 222 195481 48833 63244486
Blood bilirubin increased 14.47 9.54 62 195641 37078 63256241
Acute kidney injury 14.44 9.54 664 195039 262751 63030568
Dissociative amnesia 14.43 9.54 5 195698 29 63293290
Borderline personality disorder 14.38 9.54 15 195688 796 63292523
Urine abnormality 14.37 9.54 51 195652 6968 63286351
Multiple sclerosis 14.29 9.54 126 195577 24246 63269073
Dysaesthesia 14.29 9.54 38 195665 4440 63288879
Polydipsia 14.28 9.54 33 195670 3531 63289788
Balance disorder 14.28 9.54 351 195352 84071 63209248
Blood creatine phosphokinase increased 14.23 9.54 150 195553 30280 63263039
Conversion disorder 14.19 9.54 22 195681 1742 63291577
Neutrophil count abnormal 14.12 9.54 29 195674 2863 63290456
Increased appetite 14.10 9.54 63 195640 9567 63283752
Antisocial behaviour 14.09 9.54 11 195692 398 63292921
Palpitations 14.07 9.54 451 195252 112319 63181000
Blood pressure decreased 14.06 9.54 280 195423 64742 63228577
Alanine aminotransferase increased 14.03 9.54 230 195473 103540 63189779
Therapy interrupted 14.02 9.54 52 195651 32403 63260916
Ureteric dilatation 14.02 9.54 5 195698 32 63293287
Incoherent 14.01 9.54 38 195665 4492 63288827
Localised infection 13.99 9.54 47 195656 30163 63263156
Throat irritation 13.97 9.54 64 195639 37583 63255736
Ejection fraction decreased 13.93 9.54 30 195673 22302 63271017
Peripheral circulatory failure 13.85 9.54 16 195687 952 63292367
Pupil fixed 13.77 9.54 22 195681 1787 63291532
Injection site pruritus 13.76 9.54 82 195621 45034 63248285
Amniorrhexis 13.76 9.54 5 195698 34 63293285
Visual field defect 13.71 9.54 48 195655 6513 63286806
Parotid gland enlargement 13.68 9.54 15 195688 843 63292476
Blood ethanol increased 13.63 9.54 7 195696 119 63293200
Peritoneal perforation 13.63 9.54 7 195696 119 63293200
Tension headache 13.60 9.54 41 195662 5145 63288174
Hypertension 13.57 9.54 713 194990 278590 63014729
Sciatica 13.55 9.54 57 195646 34267 63259052
Hepatic steatosis 13.54 9.54 142 195561 28627 63264692
Gallbladder disorder 13.53 9.54 102 195601 18740 63274579
Adjusted calcium decreased 13.50 9.54 8 195695 182 63293137
Anaesthesia 13.49 9.54 11 195692 424 63292895
Reversible airways obstruction 13.48 9.54 22 195681 1820 63291499
Toxic epidermal necrolysis 13.46 9.54 37 195666 25297 63268022
Trismus 13.46 9.54 34 195669 3851 63289468
Pseudomonas infection 13.46 9.54 9 195694 11204 63282115
Activated partial thromboplastin time abnormal 13.42 9.54 7 195696 123 63293196
Periventricular leukomalacia 13.37 9.54 7 195696 124 63293195
Lung disorder 13.34 9.54 125 195578 62136 63231183
Osteoarthritis 13.33 9.54 210 195493 95133 63198186
Disinhibition 13.32 9.54 15 195688 868 63292451
Drug dose titration not performed 13.27 9.54 12 195691 533 63292786
Bronchopulmonary aspergillosis 13.26 9.54 5 195698 8630 63284689
Impaired self-care 13.23 9.54 22 195681 1848 63291471
Pneumonia viral 13.18 9.54 4 195699 7918 63285401
Lower limb fracture 13.15 9.54 35 195668 24186 63269133
Hypervigilance 13.14 9.54 10 195693 348 63292971
Hyponatraemic syndrome 13.09 9.54 12 195691 543 63292776
Hepatic cytolysis 13.03 9.54 17 195686 15390 63277929
Miosis 13.03 9.54 51 195652 7302 63286017
Cytopenia 13.02 9.54 10 195693 11591 63281728
Renal impairment 12.90 9.54 193 195510 88162 63205157
Antipsychotic drug level above therapeutic 12.89 9.54 16 195687 1027 63292292
Tinnitus 12.83 9.54 167 195536 35461 63257858
Reflexes abnormal 12.80 9.54 13 195690 668 63292651
Pleural effusion 12.80 9.54 206 195497 93004 63200315
Sensory disturbance 12.79 9.54 79 195624 13593 63279726
Pickwickian syndrome 12.78 9.54 10 195693 363 63292956
Indifference 12.75 9.54 7 195696 137 63293182
Post procedural haematuria 12.65 9.54 5 195698 44 63293275
Congestive hepatopathy 12.64 9.54 28 195675 2914 63290405
Muscle tension dysphonia 12.62 9.54 8 195695 206 63293113
Drug ineffective for unapproved indication 12.58 9.54 58 195645 34005 63259314
Cerebral ventricular rupture 12.56 9.54 8 195695 208 63293111
Gastrointestinal sounds abnormal 12.55 9.54 34 195669 4017 63289302
Hyperacusis 12.53 9.54 23 195680 2090 63291229
Anosmia 12.50 9.54 48 195655 6812 63286507
Foot deformity 12.45 9.54 44 195659 27809 63265510
Blood creatinine increased 12.44 9.54 193 195510 87651 63205668
Hip surgery 12.44 9.54 30 195673 3301 63290018
Pneumonitis 12.41 9.54 61 195642 35161 63258158
Burns second degree 12.33 9.54 22 195681 1956 63291363
Tic 12.29 9.54 19 195684 1501 63291818
Electrolyte substitution therapy 12.29 9.54 3 195700 3 63293316
Anti-neuronal antibody positive 12.29 9.54 3 195700 3 63293316
Onychogryphosis 12.29 9.54 3 195700 3 63293316
Bisexuality 12.29 9.54 3 195700 3 63293316
Cervix haematoma uterine 12.29 9.54 3 195700 3 63293316
Menopause 12.26 9.54 27 195676 2798 63290521
Pruritus genital 12.25 9.54 26 195677 2628 63290691
Respiratory acidosis 12.24 9.54 47 195656 6668 63286651
Neutrophil Pelger-Huet anomaly present 12.24 9.54 6 195697 92 63293227
Poor quality sleep 12.18 9.54 104 195599 19831 63273488
Psychogenic seizure 12.10 9.54 20 195683 1672 63291647
Catarrh 12.02 9.54 19 195684 1530 63291789
Aphasia 12.01 9.54 155 195548 32845 63260474
Congenital tricuspid valve incompetence 12.01 9.54 6 195697 96 63293223
Disability 11.99 9.54 24 195679 18323 63274996
Exostosis 11.99 9.54 23 195680 17839 63275480
Microphthalmos 11.98 9.54 7 195696 155 63293164
Sexual inhibition 11.88 9.54 4 195699 21 63293298
Immune thrombocytopenia 11.83 9.54 64 195639 10492 63282827
COVID-19 11.81 9.54 262 195441 112841 63180478
Crepitations 11.78 9.54 5 195698 8035 63285284
Nasal obstruction 11.76 9.54 20 195683 1711 63291608
Biliary dyskinesia 11.75 9.54 26 195677 2703 63290616
Marital problem 11.75 9.54 7 195696 161 63293158
Product administered to patient of inappropriate age 11.74 9.54 29 195674 3239 63290080
Osteonecrosis of jaw 11.71 9.54 62 195641 35061 63258258
Multiple organ dysfunction syndrome 11.70 9.54 115 195588 56637 63236682
Drug abuser 11.64 9.54 27 195676 2896 63290423
Cardiospasm 11.62 9.54 21 195682 1886 63291433
Atrial tachycardia 11.58 9.54 34 195669 4206 63289113
Nodal arrhythmia 11.52 9.54 16 195687 1147 63292172
Agitation neonatal 11.49 9.54 11 195692 526 63292793
Post-traumatic stress disorder 11.48 9.54 39 195664 5212 63288107
Rhinitis 11.48 9.54 67 195636 11299 63282020
Atrophic vulvovaginitis 11.45 9.54 20 195683 1748 63291571
Sunburn 11.38 9.54 26 195677 2762 63290557
Periodic limb movement disorder 11.38 9.54 8 195695 246 63293073
White blood cell count decreased 11.37 9.54 334 195369 138770 63154549
Vascular encephalopathy 11.32 9.54 10 195693 431 63292888
Hyperventilation 11.31 9.54 43 195660 6073 63287246
Choanal atresia 11.29 9.54 4 195699 25 63293294
Diastolic hypertension 11.29 9.54 4 195699 25 63293294
Apgar score low 11.29 9.54 13 195690 771 63292548
Noninfective encephalitis 11.26 9.54 10 195693 434 63292885
Acidosis 11.20 9.54 66 195637 11167 63282152
Analgesic drug level above therapeutic 11.19 9.54 7 195696 176 63293143
Accidental exposure to product 11.14 9.54 45 195658 27360 63265959
Hypocalcaemia 11.13 9.54 55 195648 31658 63261661
Blunted affect 11.13 9.54 8 195695 255 63293064
Renal disorder 11.11 9.54 58 195645 32916 63260403
Phobia 11.08 9.54 9 195694 345 63292974
Congenital megacolon 11.08 9.54 3 195700 6 63293313
Polyarthritis 11.07 9.54 9 195694 10137 63283182
Maternal exposure timing unspecified 11.06 9.54 4 195699 7083 63286236
Regressive behaviour 11.05 9.54 7 195696 180 63293139
Caesarean section 11.01 9.54 90 195613 16942 63276377
Pleurisy 10.98 9.54 6 195697 8334 63284985
Facial bones fracture 10.94 9.54 32 195671 3950 63289369
Palmoplantar keratoderma 10.85 9.54 21 195682 1986 63291333
Narcolepsy 10.82 9.54 17 195686 1361 63291958
Vaginal haemorrhage 10.82 9.54 131 195572 27356 63265963
Upper gastrointestinal haemorrhage 10.81 9.54 97 195606 18755 63274564
Sexually inappropriate behaviour 10.81 9.54 6 195697 120 63293199
Systolic hypertension 10.79 9.54 10 195693 459 63292860
Drug level above therapeutic 10.79 9.54 36 195667 4769 63288550
Drug screen positive 10.78 9.54 30 195673 3599 63289720
Pulmonary valve incompetence 10.78 9.54 17 195686 1366 63291953
Teratogenicity 10.75 9.54 8 195695 269 63293050
No adverse event 10.74 9.54 79 195624 41326 63251993
Incision site haemorrhage 10.70 9.54 11 195692 574 63292745
Joint destruction 10.69 9.54 3 195700 6249 63287070
Urinary incontinence 10.67 9.54 148 195555 31866 63261453
Merycism 10.65 9.54 8 195695 273 63293046
Carcinoid syndrome 10.64 9.54 6 195697 124 63293195
Heterophoria 10.56 9.54 4 195699 31 63293288
Pulmonary arterial hypertension 10.54 9.54 35 195668 22542 63270777
Gastroenteritis bacterial 10.52 9.54 9 195694 371 63292948
Oedema 10.52 9.54 225 195478 97397 63195922
Breath sounds abnormal 10.47 9.54 11 195692 10962 63282357
Gastrointestinal procedural complication 10.41 9.54 7 195696 200 63293119
Musculoskeletal chest pain 10.37 9.54 105 195598 20978 63272341
Throat clearing 10.37 9.54 23 195680 2396 63290923
Neonatal sinus tachycardia 10.34 9.54 4 195699 33 63293286
Umbilical artery vascular resistance increased 10.34 9.54 4 195699 33 63293286
Unintentional medical device removal 10.34 9.54 3 195700 6112 63287207
Irregular sleep wake rhythm disorder 10.28 9.54 7 195696 204 63293115
Respiratory depression 10.27 9.54 75 195628 13640 63279679
Angiodermatitis 10.24 9.54 5 195698 76 63293243
Oral neoplasm benign 10.22 9.54 3 195700 9 63293310
Steroid dependence 10.21 9.54 19 195684 1745 63291574
Agoraphobia 10.20 9.54 9 195694 387 63292932
Hepatorenal syndrome 10.19 9.54 20 195683 1912 63291407
Myocardial depression 10.17 9.54 10 195693 494 63292825
Tendonitis 10.16 9.54 29 195674 19586 63273733
Airway remodelling 10.12 9.54 5 195698 78 63293241
Chronic spontaneous urticaria 10.11 9.54 15 195688 1142 63292177
Nystagmus 10.11 9.54 42 195661 6178 63287141
Intra-abdominal haemorrhage 10.05 9.54 23 195680 2446 63290873
Pancreatic injury 10.04 9.54 4 195699 36 63293283
Dermatochalasis 9.99 9.54 3 195700 10 63293309
Antisocial personality disorder 9.99 9.54 3 195700 10 63293309
Right ventricular failure 9.98 9.54 24 195679 17164 63276155
Violence-related symptom 9.97 9.54 9 195694 399 63292920
Corneal reflex decreased 9.95 9.54 6 195697 141 63293178
Anaemia 9.95 9.54 774 194929 292656 63000663
Contraindicated product prescribed 9.93 9.54 16 195687 1309 63292010
Sudden cardiac death 9.92 9.54 21 195682 2119 63291200
Hypopnoea 9.90 9.54 30 195673 3776 63289543
Dysphemia 9.89 9.54 24 195679 2651 63290668
Hypersexuality 9.88 9.54 10 195693 512 63292807
Joint stiffness 9.87 9.54 82 195621 41787 63251532
Tuberculosis 9.87 9.54 12 195691 11199 63282120
Therapy partial responder 9.82 9.54 11 195692 10647 63282672
Oromandibular dystonia 9.80 9.54 10 195693 517 63292802
Myocardial fibrosis 9.80 9.54 12 195691 760 63292559
Joint ankylosis 9.78 9.54 14 195689 1032 63292287
Ceruloplasmin decreased 9.77 9.54 3 195700 11 63293308
Glaucoma 9.75 9.54 28 195675 18877 63274442
Neonatal infection 9.73 9.54 6 195697 147 63293172
Tubulointerstitial nephritis 9.73 9.54 99 195604 19804 63273515
Drug level increased 9.68 9.54 110 195593 22626 63270693
Fear of injection 9.66 9.54 5 195698 7159 63286160
Micturition disorder 9.63 9.54 23 195680 2515 63290804
Affective disorder 9.60 9.54 41 195662 6105 63287214
Q fever 9.59 9.54 6 195697 151 63293168
CSF white blood cell count increased 9.59 9.54 4 195699 41 63293278
Rectal haemorrhage 9.57 9.54 208 195495 48822 63244497
Prescribed underdose 9.57 9.54 53 195650 29636 63263683
Blood copper decreased 9.56 9.54 3 195700 12 63293307
Congenital lymphoedema 9.56 9.54 3 195700 12 63293307
Blood osmolarity decreased 9.54 9.54 13 195690 915 63292404
Oral candidiasis 9.54 9.54 37 195666 22761 63270558

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1016.16 10.74 1273 91177 96895 34767586
Toxicity to various agents 893.28 10.74 1762 90688 198600 34665881
Serotonin syndrome 526.00 10.74 430 92020 19503 34844978
Drug abuse 459.86 10.74 888 91562 98208 34766273
Suicidal ideation 452.68 10.74 546 91904 39842 34824639
Intentional overdose 297.39 10.74 464 91986 43210 34821271
Overdose 289.96 10.74 701 91749 90358 34774123
Suicide attempt 276.71 10.74 423 92027 38693 34825788
Paranoia 248.50 10.74 226 92224 11842 34852639
Foetal exposure during pregnancy 233.62 10.74 386 92064 37715 34826766
Drug interaction 218.20 10.74 1174 91276 224772 34639709
Tearfulness 215.93 10.74 116 92334 2551 34861930
Anxiety 213.03 10.74 662 91788 98766 34765715
Disinhibition 200.57 10.74 118 92332 3108 34861373
Psychiatric decompensation 200.06 10.74 114 92336 2823 34861658
Depression suicidal 197.35 10.74 107 92343 2398 34862083
Depressive symptom 192.14 10.74 110 92340 2749 34861732
Obsessive-compulsive disorder 187.94 10.74 139 92311 5425 34859056
Antipsychotic drug level below therapeutic 181.97 10.74 102 92348 2445 34862036
Electrocardiogram QT prolonged 167.99 10.74 349 92101 40603 34823878
Respiratory disorder neonatal 160.94 10.74 81 92369 1549 34862932
Therapeutic product effect variable 153.12 10.74 90 92360 2366 34862115
Intentional self-injury 152.21 10.74 185 92265 13586 34850895
Off label use 150.93 10.74 586 91864 418938 34445543
Akathisia 147.95 10.74 142 92308 7967 34856514
Psychomotor skills impaired 146.55 10.74 104 92346 3802 34860679
Drug withdrawal syndrome neonatal 139.58 10.74 98 92352 3521 34860960
Aggression 135.81 10.74 311 92139 38653 34825828
Agitation neonatal 130.82 10.74 62 92388 1034 34863447
Euphoric mood 130.77 10.74 113 92337 5528 34858953
Poisoning 129.88 10.74 161 92289 12065 34852416
Psychotic disorder 125.38 10.74 229 92221 24223 34840258
Irritability 122.53 10.74 228 92222 24462 34840019
Increased appetite 122.32 10.74 123 92327 7306 34857175
Depression 120.86 10.74 543 91907 96555 34767926
Febrile neutropenia 120.07 10.74 111 92339 136738 34727743
Loss of libido 119.67 10.74 78 92372 2474 34862007
Agitation 118.94 10.74 378 92072 57021 34807460
Depressed mood 113.40 10.74 192 92258 19125 34845356
Respiratory arrest 111.49 10.74 236 92214 27807 34836674
Pyrexia 109.04 10.74 482 91968 332531 34531950
Restlessness 106.62 10.74 219 92231 25263 34839218
Confusional state 106.52 10.74 699 91751 143461 34721020
Small for dates baby 104.11 10.74 85 92365 3842 34860639
Hypertonia neonatal 103.84 10.74 41 92409 426 34864055
Neonatal respiratory distress syndrome 100.03 10.74 84 92366 3950 34860531
Atrial septal defect 92.78 10.74 106 92344 7286 34857195
Disturbance in attention 92.51 10.74 209 92241 25736 34838745
Sexual dysfunction 90.53 10.74 97 92353 6206 34858275
Intrusive thoughts 89.25 10.74 33 92417 282 34864199
Orgasmic sensation decreased 86.53 10.74 23 92427 52 34864429
Tremor 82.67 10.74 434 92016 82153 34782328
Erectile dysfunction 80.08 10.74 172 92278 20465 34844016
Pneumonia 76.93 10.74 603 91847 362024 34502457
Psychomotor retardation 76.38 10.74 69 92381 3581 34860900
Homicidal ideation 73.10 10.74 59 92391 2623 34861858
Acute kidney injury 72.42 10.74 491 91959 304497 34559984
Anger 69.58 10.74 118 92332 11766 34852715
Asphyxia 69.38 10.74 88 92362 6747 34857734
Neonatal hypoxia 67.60 10.74 29 92421 378 34864103
Cardio-respiratory arrest 67.12 10.74 307 92143 54966 34809515
Temperature regulation disorder 66.93 10.74 35 92415 727 34863754
Malignant neoplasm progression 66.45 10.74 81 92369 87965 34776516
Interstitial lung disease 65.90 10.74 46 92404 65236 34799245
Maternal drugs affecting foetus 62.27 10.74 64 92386 3901 34860580
Sepsis 61.93 10.74 229 92221 166332 34698149
Sedation 60.68 10.74 156 92294 20850 34843631
Libido decreased 60.05 10.74 68 92382 4628 34859853
Tachyphrenia 60.02 10.74 39 92411 1230 34863251
Diarrhoea 58.68 10.74 705 91745 389207 34475274
Neonatal seizure 58.59 10.74 28 92422 476 34864005
Hepatic function abnormal 58.55 10.74 22 92428 44341 34820140
Fall 58.51 10.74 805 91645 202080 34662401
Genital hypoaesthesia 57.46 10.74 22 92428 209 34864272
Accidental death 56.52 10.74 49 92401 2407 34862074
Septic shock 56.43 10.74 64 92386 71770 34792711
Sopor 56.39 10.74 109 92341 12027 34852454
Hallucination 55.95 10.74 277 92173 51221 34813260
Cryptorchism 55.84 10.74 45 92405 1996 34862485
Panic attack 55.67 10.74 94 92356 9338 34855143
Obesity 55.42 10.74 112 92338 12766 34851715
Multiple organ dysfunction syndrome 55.11 10.74 73 92377 76493 34787988
Prescribed overdose 54.92 10.74 100 92350 10547 34853934
Somnambulism 54.53 10.74 53 92397 3019 34861462
Muscle rigidity 54.52 10.74 99 92351 10419 34854062
Bradycardia neonatal 53.68 10.74 33 92417 943 34863538
Mental impairment 53.31 10.74 97 92353 10225 34854256
Hallucination, auditory 52.91 10.74 105 92345 11812 34852669
Exposure during pregnancy 52.68 10.74 89 92361 8845 34855636
Intentional product misuse 52.18 10.74 249 92201 45362 34819119
Homicide 51.97 10.74 32 92418 917 34863564
Disease progression 51.21 10.74 133 92317 107944 34756537
Cytomegalovirus infection 51.01 10.74 5 92445 26130 34838351
Platelet count decreased 50.33 10.74 156 92294 119561 34744920
Rhinitis perennial 50.07 10.74 22 92428 305 34864176
Withdrawal syndrome 49.69 10.74 105 92345 12350 34852131
Mood swings 49.66 10.74 81 92369 7820 34856661
Somnolence 49.57 10.74 480 91970 110636 34753845
Hallucination, visual 49.21 10.74 130 92320 17661 34846820
Hypospadias 49.06 10.74 51 92399 3150 34861331
Disturbance in sexual arousal 47.50 10.74 17 92433 131 34864350
Drug screen positive 46.90 10.74 55 92395 3888 34860593
Poverty of speech 46.53 10.74 19 92431 217 34864264
Cardiac failure 45.79 10.74 109 92341 91139 34773342
Derealisation 45.64 10.74 25 92425 572 34863909
Logorrhoea 45.23 10.74 43 92407 2383 34862098
Muscle twitching 44.83 10.74 90 92360 10208 34854273
Coma scale abnormal 44.53 10.74 54 92396 3954 34860527
COVID-19 44.43 10.74 86 92364 77464 34787017
Hypoglycaemia neonatal 43.89 10.74 38 92412 1863 34862618
Mydriasis 43.88 10.74 73 92377 7164 34857317
Parathyroid gland enlargement 42.84 10.74 16 92434 141 34864340
Cardiac arrest 42.69 10.74 415 92035 95744 34768737
Drug reaction with eosinophilia and systemic symptoms 42.52 10.74 17 92433 32995 34831486
Hypomania 42.44 10.74 41 92409 2318 34862163
Neutropenia 41.95 10.74 243 92207 156535 34707946
Upper respiratory fungal infection 41.33 10.74 16 92434 157 34864324
Myoclonus 41.13 10.74 108 92342 14617 34849864
Renal failure 40.73 10.74 192 92258 130365 34734116
Mucosal inflammation 40.60 10.74 26 92424 38596 34825885
Haemangioma congenital 40.45 10.74 22 92428 496 34863985
Leukaemia 40.13 10.74 55 92395 4548 34859933
Infantile apnoea 39.35 10.74 27 92423 934 34863547
Depressed level of consciousness 38.69 10.74 219 92231 42622 34821859
Hyperreflexia 38.60 10.74 45 92405 3161 34861320
Cytokine release syndrome 38.42 10.74 7 92443 22870 34841611
Congenital ureteropelvic junction obstruction 38.25 10.74 12 92438 58 34864423
Dyslipidaemia 38.20 10.74 70 92380 7418 34857063
Premature ejaculation 38.03 10.74 14 92436 118 34864363
Drug ineffective 37.89 10.74 920 91530 455831 34408650
Stomatitis 37.81 10.74 34 92416 42480 34822001
Hanging 37.72 10.74 15 92435 159 34864322
Alcohol use 37.68 10.74 45 92405 3243 34861238
Atrial fibrillation 37.59 10.74 181 92269 122212 34742269
Drug withdrawal syndrome 36.90 10.74 126 92324 19708 34844773
Vasoplegia syndrome 36.72 10.74 34 92416 1822 34862659
Ventricular septal defect 36.69 10.74 49 92401 3952 34860529
Anaemia 36.48 10.74 418 92032 232917 34631564
Amnesia 36.38 10.74 153 92297 26410 34838071
Prescription drug used without a prescription 36.07 10.74 36 92414 2118 34862363
Neuropathy peripheral 36.05 10.74 107 92343 83156 34781325
Pleural effusion 35.88 10.74 104 92346 81442 34783039
Oedema peripheral 35.74 10.74 179 92271 119633 34744848
Disorientation 35.67 10.74 178 92272 33010 34831471
Mania 35.44 10.74 78 92372 9433 34855048
Dyskinesia 35.42 10.74 135 92315 22278 34842203
Congenital hepatomegaly 35.29 10.74 9 92441 16 34864465
Hyperhidrosis 35.23 10.74 330 92120 75362 34789119
Inappropriate antidiuretic hormone secretion 35.08 10.74 93 92357 12660 34851821
Forced expiratory volume 34.96 10.74 13 92437 113 34864368
Anorgasmia 34.91 10.74 24 92426 833 34863648
Respiratory failure 34.85 10.74 158 92292 108414 34756067
Thrombocytopenia 34.78 10.74 256 92194 155991 34708490
Rheumatoid arthritis 34.70 10.74 30 92420 38208 34826273
Loss of consciousness 34.37 10.74 352 92098 82315 34782166
Mental disorder 34.09 10.74 103 92347 15106 34849375
Adjustment disorder 33.96 10.74 27 92423 1174 34863307
Negative thoughts 33.25 10.74 21 92429 630 34863851
Hyperventilation 32.94 10.74 39 92411 2785 34861696
Pneumonitis 32.71 10.74 25 92425 33853 34830628
Renal impairment 32.49 10.74 134 92316 94379 34770102
Drug resistance 32.34 10.74 14 92436 25913 34838568
Bipolar disorder 32.23 10.74 44 92406 3625 34860856
Electrocardiogram QRS complex prolonged 31.89 10.74 51 92399 4843 34859638
Unresponsive to stimuli 31.88 10.74 151 92299 27418 34837063
Circulatory collapse 31.84 10.74 125 92325 20913 34843568
Apgar score low 31.67 10.74 23 92427 872 34863609
Newborn persistent pulmonary hypertension 31.25 10.74 12 92438 115 34864366
Gun shot wound 31.13 10.74 25 92425 1103 34863378
Pancytopenia 30.82 10.74 138 92312 95019 34769462
Tardive dyskinesia 30.65 10.74 55 92395 5735 34858746
Product use in unapproved indication 30.41 10.74 184 92266 117315 34747166
Limb deformity 29.99 10.74 19 92431 573 34863908
Nightmare 29.98 10.74 95 92355 14296 34850185
Failure to suspend medication 29.83 10.74 17 92433 421 34864060
Optic nerve hypoplasia 29.63 10.74 6 92444 0 34864481
Weight increased 29.59 10.74 376 92074 92657 34771824
Apathy 29.48 10.74 60 92390 6872 34857609
Patent ductus arteriosus 29.12 10.74 40 92410 3314 34861167
Toxicologic test abnormal 28.56 10.74 18 92432 538 34863943
Selective eating disorder 28.46 10.74 29 92421 1749 34862732
C-reactive protein increased 28.43 10.74 63 92387 54035 34810446
Drug hypersensitivity 28.41 10.74 113 92337 80416 34784065
Psychomotor hyperactivity 28.34 10.74 72 92378 9550 34854931
Myelosuppression 28.15 10.74 8 92442 19257 34845224
Foot deformity 27.82 10.74 46 92404 4491 34859990
Spontaneous penile erection 27.69 10.74 13 92437 212 34864269
Pregnancy 27.61 10.74 14 92436 272 34864209
Hyperbilirubinaemia neonatal 27.45 10.74 20 92430 762 34863719
Hypotonia neonatal 27.31 10.74 25 92425 1320 34863161
Impaired work ability 27.15 10.74 58 92392 6872 34857609
Torsade de pointes 26.72 10.74 59 92391 7150 34857331
Prostate cancer 26.33 10.74 40 92410 39609 34824872
Sexual relationship change 26.28 10.74 7 92443 16 34864465
Hypertonia 25.97 10.74 43 92407 4203 34860278
Infection 25.88 10.74 138 92312 90777 34773704
Tremor neonatal 25.77 10.74 15 92435 387 34864094
Eosinophilia 25.76 10.74 19 92431 26203 34838278
Pneumocystis jirovecii pneumonia 25.63 10.74 10 92440 19700 34844781
Radiologically isolated syndrome 25.48 10.74 6 92444 6 34864475
Impulsive behaviour 25.45 10.74 30 92420 2132 34862349
Disseminated intravascular coagulation 25.33 10.74 13 92437 21803 34842678
Decreased appetite 25.23 10.74 300 92150 166092 34698389
Finnegan score increased 24.92 10.74 7 92443 21 34864460
Intentional product misuse to child 24.69 10.74 5 92445 0 34864481
Congenital hypercoagulation 24.69 10.74 5 92445 0 34864481
Synovitis 24.29 10.74 4 92446 14062 34850419
Oedema 24.26 10.74 53 92397 45688 34818793
Clonus 24.18 10.74 33 92417 2717 34861764
Haemophagocytic lymphohistiocytosis 24.00 10.74 3 92447 12970 34851511
Infusion related reaction 23.82 10.74 67 92383 52990 34811491
Schizoaffective disorder 23.75 10.74 23 92427 1304 34863177
Heat stroke 23.73 10.74 20 92430 945 34863536
Neonatal pneumonia 23.68 10.74 10 92440 125 34864356
Congenital pulmonary hypertension 23.65 10.74 9 92441 84 34864397
Seizure 23.56 10.74 399 92051 104458 34760023
Bronchopulmonary aspergillosis 23.53 10.74 5 92445 14654 34849827
Panic reaction 23.51 10.74 24 92426 1451 34863030
Antipsychotic drug level increased 23.45 10.74 39 92411 3826 34860655
Tumour lysis syndrome 23.29 10.74 8 92442 17051 34847430
Delusion 23.27 10.74 80 92370 12555 34851926
Kinematic imbalances due to suboccipital strain 23.07 10.74 6 92444 12 34864469
Parkinsonism 23.05 10.74 60 92390 8078 34856403
Dissociation 22.91 10.74 25 92425 1633 34862848
Conduction disorder 22.75 10.74 28 92422 2082 34862399
Thrombosis 22.44 10.74 64 92386 50394 34814087
Bladder trabeculation 22.35 10.74 5 92445 3 34864478
Dreamy state 22.15 10.74 6 92444 15 34864466
Neonatal disorder 22.07 10.74 18 92432 812 34863669
Myocardial fibrosis 21.90 10.74 21 92429 1176 34863305
Congenital hydronephrosis 21.85 10.74 17 92433 716 34863765
Myocardial infarction 21.69 10.74 210 92240 120875 34743606
Tic 21.69 10.74 27 92423 2031 34862450
Feeling abnormal 21.57 10.74 259 92191 62976 34801505
Mental status changes 21.33 10.74 173 92277 37910 34826571
Lactic acidosis 21.29 10.74 37 92413 34735 34829746
Major depression 21.16 10.74 41 92409 4531 34859950
Joint swelling 21.14 10.74 84 92366 59806 34804675
Infant irritability 21.06 10.74 7 92443 42 34864439
Maternal exposure during breast feeding 20.88 10.74 23 92427 1518 34862963
Toxic epidermal necrolysis 20.86 10.74 16 92434 21630 34842851
Interstitial granulomatous dermatitis 20.82 10.74 10 92440 172 34864309
Gender dysphoria 20.78 10.74 7 92443 44 34864437
Constipation 20.74 10.74 247 92203 136735 34727746
Drug dependence 20.68 10.74 122 92328 24095 34840386
Dyspnoea 20.55 10.74 802 91648 375980 34488501
Agoraphobia 20.51 10.74 11 92439 241 34864240
Postmortem blood drug level increased 20.43 10.74 11 92439 243 34864238
Epistaxis 20.38 10.74 82 92368 58169 34806312
Substance abuse 20.28 10.74 55 92395 7586 34856895
Thinking abnormal 20.28 10.74 48 92402 6089 34858392
Blood alcohol increased 20.12 10.74 17 92433 806 34863675
Bacterial infection 20.06 10.74 10 92440 17053 34847428
Sexually inappropriate behaviour 20.06 10.74 14 92436 498 34863983
Pulmonary oedema 20.03 10.74 203 92247 47326 34817155
Brain oedema 20.02 10.74 81 92369 13740 34850741
Hyponatraemic syndrome 19.88 10.74 10 92440 191 34864290
Pilonidal cyst congenital 19.84 10.74 6 92444 25 34864456
Congenital central nervous system anomaly 19.80 10.74 15 92435 607 34863874
Peripheral swelling 19.72 10.74 120 92330 76421 34788060
Suicidal behaviour 19.69 10.74 22 92428 1475 34863006
Hyperbilirubinaemia 19.61 10.74 10 92440 16833 34847648
Victim of chemical submission 19.44 10.74 7 92443 55 34864426
Cough 19.34 10.74 280 92170 149860 34714621
Persistent foetal circulation 19.21 10.74 12 92438 353 34864128
Wrong product administered 19.04 10.74 43 92407 5291 34859190
Choanal atresia 18.90 10.74 5 92445 11 34864470
Anhidrosis 18.88 10.74 8 92442 101 34864380
Parkinson's disease 18.86 10.74 21 92429 1403 34863078
Medication error 18.84 10.74 124 92326 25441 34839040
Osmolar gap abnormal 18.79 10.74 6 92444 31 34864450
Decreased interest 18.79 10.74 27 92423 2333 34862148
Bradyphrenia 18.62 10.74 40 92410 4758 34859723
Intestinal congestion 18.60 10.74 5 92445 12 34864469
Poor quality sleep 18.59 10.74 56 92394 8200 34856281
Dysphemia 18.56 10.74 22 92428 1573 34862908
Bladder cancer 18.46 10.74 10 92440 16268 34848213
Neuroleptic malignant syndrome 18.43 10.74 95 92355 17839 34846642
Hypercalcaemia 18.29 10.74 9 92441 15459 34849022
Blood bilirubin increased 18.21 10.74 47 92403 38249 34826232
Accidental overdose 18.20 10.74 103 92347 20037 34844444
Diffuse large B-cell lymphoma stage II 18.19 10.74 6 92444 35 34864446
Duodenal ulcer perforation 18.15 10.74 22 92428 1610 34862871
Hospitalisation 18.12 10.74 83 92367 56819 34807662
Tachycardia 18.10 10.74 320 92130 84452 34780029
Insomnia 18.03 10.74 380 92070 103527 34760954
Bone marrow failure 18.03 10.74 31 92419 29222 34835259
Rash 18 10.74 450 92000 222302 34642179
Salivary hypersecretion 17.94 10.74 57 92393 8587 34855894
Haematuria 17.81 10.74 70 92380 49996 34814485
Neonatal infection 17.75 10.74 12 92438 405 34864076
Abnormal behaviour 17.73 10.74 120 92330 24849 34839632
Cardiogenic shock 17.53 10.74 27 92423 26591 34837890
Leukopenia 17.48 10.74 248 92202 62608 34801873
Colitis 17.44 10.74 47 92403 37703 34826778
Exposure via ingestion 17.43 10.74 25 92425 2156 34862325
Self-medication 17.38 10.74 28 92422 2675 34861806
Coordination abnormal 17.35 10.74 52 92398 7592 34856889
Influenza 17.32 10.74 70 92380 49596 34814885
Cytopenia 17.31 10.74 6 92444 12717 34851764
Ascites 17.29 10.74 64 92386 46507 34817974
Abdominal distension 17.08 10.74 88 92362 58404 34806077
Arthropathy 17.05 10.74 28 92422 26879 34837602
COVID-19 pneumonia 17.05 10.74 12 92438 16955 34847526
Libido disorder 17.01 10.74 10 92440 263 34864218
Hyponatraemia 16.90 10.74 310 92140 82381 34782100
Hepatitis C virus test positive 16.90 10.74 11 92439 348 34864133
Liver disorder 16.87 10.74 39 92411 32958 34831523
Lymphoma 16.84 10.74 6 92444 12501 34851980
Economic problem 16.84 10.74 19 92431 1288 34863193
Alcoholism 16.77 10.74 29 92421 2936 34861545
Urticaria 16.48 10.74 97 92353 62280 34802201
Drug-induced liver injury 16.48 10.74 32 92418 28800 34835681
Incontinence 16.45 10.74 43 92407 5804 34858677
Bronchopulmonary aspergillosis allergic 16.44 10.74 16 92434 913 34863568
Wrong patient received product 16.40 10.74 27 92423 2627 34861854
Dyspnoea exertional 16.38 10.74 59 92391 43220 34821261
Nasopharyngitis 16.34 10.74 113 92337 69855 34794626
Myelodysplastic syndrome 16.32 10.74 16 92434 19192 34845289
Rectourethral fistula 16.32 10.74 5 92445 22 34864459
Opiates positive 16.30 10.74 13 92437 568 34863913
Osteonecrosis of jaw 16.27 10.74 14 92436 17875 34846606
Xanthoma 16.20 10.74 7 92443 93 34864388
Slow response to stimuli 16.18 10.74 15 92435 805 34863676
Spermatozoa morphology abnormal 16.10 10.74 4 92446 6 34864475
Blood catecholamines decreased 16.10 10.74 4 92446 6 34864475
Congenital pneumonia 16.06 10.74 7 92443 95 34864386
White blood cell count decreased 16.06 10.74 168 92282 95277 34769204
Rhinorrhoea 16 10.74 27 92423 25641 34838840
Facial spasm 15.89 10.74 9 92441 220 34864261
Generalised tonic-clonic seizure 15.78 10.74 103 92347 21071 34843410
Acute myeloid leukaemia 15.78 10.74 15 92435 18255 34846226
Bronchial disorder 15.74 10.74 19 92431 1384 34863097
Cyanosis neonatal 15.69 10.74 10 92440 305 34864176
Morbid thoughts 15.57 10.74 9 92441 229 34864252
Hand deformity 15.55 10.74 32 92418 3693 34860788
Arachnoid cyst 15.50 10.74 9 92441 231 34864250
Pneumonia bacterial 15.47 10.74 6 92444 11866 34852615
Positive end-expiratory pressure 15.38 10.74 4 92446 8 34864473
Physical assault 15.36 10.74 17 92433 1128 34863353
Hydrocele 15.35 10.74 23 92427 2064 34862417
Oesophageal carcinoma 15.30 10.74 3 92447 9301 34855180
Urinary retention 15.29 10.74 155 92295 36133 34828348
Hypertrophic cardiomyopathy 15.21 10.74 17 92433 1140 34863341
Anomaly of external ear congenital 15.20 10.74 7 92443 109 34864372
Acute stress disorder 15.18 10.74 8 92442 169 34864312
Poor feeding infant 15.03 10.74 12 92438 525 34863956
Eye haematoma 14.97 10.74 6 92444 65 34864416
Floppy infant 14.92 10.74 7 92443 114 34864367
Pruritus 14.89 10.74 275 92175 141706 34722775
Abnormal dreams 14.85 10.74 49 92401 7529 34856952
Tendon disorder 14.82 10.74 27 92423 2848 34861633
Gas poisoning 14.81 10.74 3 92447 0 34864481
Holoprosencephaly 14.81 10.74 3 92447 0 34864481
Visual snow syndrome 14.81 10.74 3 92447 0 34864481
Genital anaesthesia 14.77 10.74 4 92446 10 34864471
Hypertrophic scar 14.77 10.74 4 92446 10 34864471
Syncope 14.76 10.74 331 92119 91120 34773361
Oesophageal perforation 14.72 10.74 17 92433 1182 34863299
Caesarean section 14.72 10.74 23 92427 2141 34862340
Muscle mass 14.71 10.74 9 92441 255 34864226
Gastrointestinal mucosal exfoliation 14.70 10.74 7 92443 118 34864363
JC virus CSF test positive 14.70 10.74 7 92443 118 34864363
Periventricular leukomalacia 14.66 10.74 6 92444 69 34864412
Radicular pain 14.50 10.74 6 92444 71 34864410
Self-injurious ideation 14.50 10.74 20 92430 1664 34862817
Pneumonitis chemical 14.49 10.74 8 92442 186 34864295
Resting tremor 14.48 10.74 13 92437 669 34863812
Blood creatinine increased 14.47 10.74 171 92279 94805 34769676
Psychiatric symptom 14.46 10.74 30 92420 3483 34860998
Priapism 14.33 10.74 37 92413 4957 34859524
Thrombotic stroke 14.31 10.74 9 92441 268 34864213
Opisthotonus 14.29 10.74 11 92439 456 34864025
Granulocytopenia 14.27 10.74 44 92406 6523 34857958
Appendicitis 14.20 10.74 11 92439 14796 34849685
Angioedema 14.11 10.74 51 92399 37323 34827158
Vestibular disorder 14.10 10.74 16 92434 1091 34863390
Testicular atrophy 14.01 10.74 12 92438 580 34863901
Acute myocardial infarction 13.95 10.74 84 92366 53635 34810846
Head circumference abnormal 13.92 10.74 5 92445 39 34864442
Iron binding capacity total increased 13.92 10.74 5 92445 39 34864442
Hepatic failure 13.79 10.74 46 92404 34485 34829996
Infantile vomiting 13.70 10.74 5 92445 41 34864440
Hepatic cytolysis 13.61 10.74 11 92439 14485 34849996
Ventricular flutter 13.48 10.74 6 92444 86 34864395
Erythema 13.46 10.74 160 92290 88620 34775861
Dysarthria 13.45 10.74 146 92304 34636 34829845
Cardiac failure congestive 13.43 10.74 148 92302 83122 34781359
Lacrimation increased 13.40 10.74 3 92447 8479 34856002
Oesophageal atresia 13.38 10.74 11 92439 502 34863979
Arthralgia 13.32 10.74 345 92105 169696 34694785
Tension 13.27 10.74 22 92428 2153 34862328
Drug dispensed to wrong patient 13.17 10.74 11 92439 513 34863968
Congenital hydrocephalus 13.11 10.74 6 92444 92 34864389
Micropenis 13.11 10.74 5 92445 47 34864434
Jaundice 13.06 10.74 42 92408 31840 34832641
Activation syndrome 13.05 10.74 6 92444 93 34864388
Teratogenicity 13.01 10.74 5 92445 48 34864433
Pleurothotonus 13.01 10.74 16 92434 1189 34863292
Product use issue 12.91 10.74 106 92344 63110 34801371
Toxic skin eruption 12.90 10.74 7 92443 11378 34853103
Accidental poisoning 12.86 10.74 13 92437 777 34863704
Myositis 12.85 10.74 8 92442 12062 34852419
Thrombotic microangiopathy 12.85 10.74 6 92444 10624 34853857
Staphylococcal sepsis 12.79 10.74 5 92445 9839 34854642
Carbon monoxide poisoning 12.72 10.74 6 92444 99 34864382
Rash maculo-papular 12.71 10.74 36 92414 28415 34836066
Brugada syndrome 12.71 10.74 13 92437 788 34863693
Osteoporosis 12.68 10.74 9 92441 12659 34851822
Persistent depressive disorder 12.61 10.74 9 92441 332 34864149
Mood altered 12.59 10.74 52 92398 8900 34855581
Haematospermia 12.56 10.74 9 92441 334 34864147
Open reduction of fracture 12.56 10.74 6 92444 102 34864379
Angle closure glaucoma 12.48 10.74 14 92436 943 34863538
Blood urea increased 12.44 10.74 40 92410 30324 34834157
Hyperuricaemia 12.40 10.74 3 92447 8040 34856441
Neoplasm progression 12.35 10.74 27 92423 23273 34841208
Haemoglobin decreased 12.33 10.74 235 92215 120537 34743944
Renal disorder 12.32 10.74 31 92419 25449 34839032
Bronchitis 12.32 10.74 63 92387 41900 34822581
Semen volume decreased 12.26 10.74 9 92441 347 34864134
Coagulation factor increased 12.25 10.74 5 92445 57 34864424
Dystonia 12.24 10.74 59 92391 10786 34853695
Venoocclusive liver disease 12.22 10.74 3 92447 7963 34856518
Emotional disorder 12.15 10.74 38 92412 5678 34858803
Contraindicated product administered 12.14 10.74 24 92426 21457 34843024
Social avoidant behaviour 12.13 10.74 26 92424 3088 34861393
Dissociative disorder 12.11 10.74 10 92440 459 34864022
Drug abuser 12.08 10.74 30 92420 3924 34860557
Bacteraemia 12.05 10.74 21 92429 19696 34844785
Pulmonary embolism 12.03 10.74 166 92284 89580 34774901
Respiratory distress 11.97 10.74 51 92399 35614 34828867
Pulmonary valve stenosis 11.97 10.74 9 92441 360 34864121
Male orgasmic disorder 11.95 10.74 6 92444 114 34864367
Wrong dose 11.90 10.74 11 92439 588 34863893
Intentional product use issue 11.89 10.74 101 92349 59715 34804766
Crystalluria 11.89 10.74 10 92440 471 34864010
Personality disorder 11.79 10.74 15 92435 1153 34863328
Hypoalbuminaemia 11.73 10.74 9 92441 12165 34852316
Coagulation factor VII level decreased 11.72 10.74 6 92444 119 34864362
Personality change 11.70 10.74 35 92415 5104 34859377
Klebsiella infection 11.64 10.74 4 92446 8527 34855954
Adjusted calcium increased 11.63 10.74 4 92446 27 34864454
Adrenal insufficiency 11.59 10.74 12 92438 14035 34850446
Pulmonary artery stenosis congenital 11.54 10.74 10 92440 491 34863990
Alcoholic psychosis 11.53 10.74 3 92447 6 34864475
Liver function test increased 11.40 10.74 13 92437 14552 34849929
CSF white blood cell count positive 11.39 10.74 4 92446 29 34864452
Application site hypersensitivity 11.37 10.74 6 92444 127 34864354
Sleep disorder due to a general medical condition 11.36 10.74 35 92415 5186 34859295
Lymphocyte count decreased 11.35 10.74 27 92423 22595 34841886
Bradykinesia 11.33 10.74 29 92421 3864 34860617
Oliguria 11.32 10.74 4 92446 8376 34856105
Hepatic enzyme increased 11.29 10.74 59 92391 39021 34825460
Memory impairment 11.28 10.74 169 92281 43149 34821332
Graft versus host disease 11.26 10.74 7 92443 10562 34853919
Blood pressure fluctuation 11.24 10.74 32 92418 25217 34839264
Transaminases increased 11.22 10.74 35 92415 26788 34837693
Pericardial effusion 11.17 10.74 31 92419 24631 34839850
Kidney transplant rejection 11.16 10.74 3 92447 7494 34856987
Antidepressant drug level increased 11.16 10.74 6 92444 132 34864349
Product administered to patient of inappropriate age 11.16 10.74 26 92424 3265 34861216
Antipsychotic drug level above therapeutic 11.15 10.74 15 92435 1218 34863263
Treatment failure 11.11 10.74 75 92375 46622 34817859
Dysphoria 11.09 10.74 21 92429 2281 34862200
HIV peripheral neuropathy 11.05 10.74 4 92446 32 34864449
Infertility 11.02 10.74 7 92443 212 34864269
Diabetic foetopathy 11.02 10.74 7 92443 212 34864269
Product dose omission issue 11.00 10.74 237 92213 119474 34745007
Reduced facial expression 11.00 10.74 14 92436 1077 34863404
Alcohol interaction 10.98 10.74 24 92426 2889 34861592
Anaphylactic reaction 10.96 10.74 46 92404 32255 34832226
Chronic kidney disease 10.93 10.74 64 92386 41146 34823335
Dissociative amnesia 10.91 10.74 5 92445 77 34864404
Cognitive disorder 10.89 10.74 120 92330 28573 34835908
Yawning 10.86 10.74 10 92440 532 34863949
Application site reaction 10.85 10.74 9 92441 416 34864065
Poor personal hygiene 10.82 10.74 8 92442 312 34864169
Incoherent 10.79 10.74 31 92419 4421 34860060
Therapy partial responder 10.77 10.74 6 92444 9610 34854871
Product storage error 10.76 10.74 4 92446 8118 34856363

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2255.12 9.72 3183 232892 242584 79265729
Toxicity to various agents 1944.58 9.72 4018 232057 417522 79090791
Drug abuse 1382.90 9.72 2034 234041 160657 79347656
Serotonin syndrome 1019.05 9.72 934 235141 44093 79464220
Electrocardiogram QT prolonged 741.14 9.72 1112 234963 89274 79419039
Overdose 715.84 9.72 1642 234433 182564 79325749
Drug interaction 629.43 9.72 2663 233412 412520 79095793
Intentional overdose 625.60 9.72 1124 234951 104836 79403477
Suicidal ideation 616.94 9.72 933 235142 75407 79432906
Suicide attempt 478.29 9.72 871 235204 82061 79426252
Respiratory arrest 355.57 9.72 623 235452 56927 79451386
Sopor 355.25 9.72 463 235612 32547 79475766
Synovitis 330.27 9.72 32 236043 150702 79357611
Anxiety 325.11 9.72 1527 234548 246985 79261328
Intentional self-injury 324.69 9.72 439 235636 31980 79476333
Agitation 322.81 9.72 829 235246 98886 79409427
Poisoning 322.38 9.72 386 235689 24886 79483427
Off label use 282.59 9.72 1557 234518 905658 78602655
Cardio-respiratory arrest 280.62 9.72 831 235244 107679 79400634
Drug ineffective 272.17 9.72 1981 234094 1078932 78429381
Torsade de pointes 271.37 9.72 310 235765 19002 79489311
Hand deformity 256.90 9.72 12 236063 103907 79404406
Tremor 241.52 9.72 1071 235004 169012 79339301
Temperature regulation disorder 224.23 9.72 165 235910 5688 79502625
Hyponatraemia 221.65 9.72 1078 234997 176770 79331543
Pemphigus 221.15 9.72 20 236055 99562 79408751
Paranoia 214.44 9.72 276 235799 19156 79489157
Systemic lupus erythematosus 204.51 9.72 53 236022 121096 79387217
Febrile neutropenia 197.19 9.72 236 235839 230763 79277550
Hyperhidrosis 195.06 9.72 927 235148 150565 79357748
Arthropathy 188.15 9.72 149 235926 176962 79331351
Depression suicidal 186.03 9.72 125 235950 3717 79504596
Treatment failure 180.38 9.72 144 235931 170342 79337971
Cardiac arrest 180.32 9.72 994 235081 171102 79337211
Aggression 178.83 9.72 437 235638 50521 79457792
Pericarditis 175.17 9.72 46 236029 104190 79404123
Restlessness 173.15 9.72 408 235667 46084 79462229
Helicobacter infection 172.43 9.72 8 236067 69696 79438617
Tearfulness 172.12 9.72 143 235932 5902 79502411
Depression 169.58 9.72 1161 234914 215629 79292684
Disturbance in attention 169.15 9.72 427 235648 50374 79457939
Drug intolerance 168.53 9.72 329 235746 263790 79244523
Panic attack 166.50 9.72 275 235800 23941 79484372
Somnolence 166.18 9.72 1244 234831 237737 79270576
Therapeutic product effect decreased 161.64 9.72 148 235927 163715 79344598
Psychiatric decompensation 161.54 9.72 116 235959 3847 79504466
Loss of libido 161.18 9.72 100 235975 2585 79505728
Fall 159.20 9.72 2170 233905 485459 79022854
Food allergy 157.59 9.72 177 235898 10647 79497666
Irritability 155.32 9.72 363 235712 40781 79467532
Infusion related reaction 151.95 9.72 281 235794 229956 79278357
Rheumatoid factor positive 150.90 9.72 6 236069 59833 79448480
Depressive symptom 146.70 9.72 134 235941 6289 79502024
Electrocardiogram QRS complex prolonged 143.98 9.72 169 235906 10664 79497649
Coeliac disease 142.50 9.72 172 235903 11179 79497134
Withdrawal syndrome 142.15 9.72 272 235803 26582 79481731
Confusional state 140.84 9.72 1500 234575 316497 79191816
Psychotic disorder 137.83 9.72 348 235727 41054 79467259
Glossodynia 137.29 9.72 67 236008 103270 79405043
Mydriasis 134.49 9.72 210 235865 17433 79490880
Alopecia 132.67 9.72 306 235769 231049 79277264
Pyrexia 131.08 9.72 1331 234744 677378 78830935
Infection 129.69 9.72 331 235744 241381 79266932
Accidental overdose 128.96 9.72 330 235745 39251 79469062
Akathisia 127.38 9.72 176 235899 13083 79495230
Psychomotor skills impaired 126.98 9.72 113 235962 5124 79503189
Myoclonus 124.67 9.72 262 235813 27398 79480915
Interstitial lung disease 124.32 9.72 91 235984 112509 79395804
Joint swelling 124.16 9.72 438 235637 288208 79220105
Accidental death 123.20 9.72 102 235973 4189 79504124
Loss of consciousness 122.82 9.72 885 235190 167058 79341255
Muscle twitching 122.77 9.72 244 235831 24520 79483793
Muscle injury 122.01 9.72 5 236070 48556 79459757
Malignant neoplasm progression 121.33 9.72 134 235941 135856 79372457
Muscle rigidity 121.15 9.72 214 235861 19668 79488645
Depressed mood 120.26 9.72 366 235709 48114 79460199
Intentional product misuse 120.01 9.72 579 235496 94586 79413727
Seizure 119.56 9.72 962 235113 187872 79320441
Nightmare 117.77 9.72 246 235829 25615 79482698
Anorgasmia 116.28 9.72 62 236013 1192 79507121
Duodenal ulcer perforation 115.55 9.72 27 236048 66184 79442129
Unresponsive to stimuli 114.71 9.72 395 235680 55393 79452920
Pneumonia 109.91 9.72 1339 234736 658907 78849406
Hyperreflexia 106.80 9.72 128 235947 8257 79500056
Wound 106.39 9.72 112 235963 116067 79392246
Sleep disorder due to general medical condition, insomnia type 104.57 9.72 6 236069 43550 79464763
Septic shock 103.09 9.72 127 235948 122674 79385639
Stomatitis 102.30 9.72 173 235902 146584 79361729
Obsessive-compulsive disorder 102.21 9.72 106 235969 5821 79502492
Hallucination 101.92 9.72 513 235562 85232 79423081
Drug withdrawal syndrome 101.47 9.72 278 235797 34440 79473873
Neutropenia 99.07 9.72 476 235599 287234 79221079
Coma scale abnormal 98.49 9.72 125 235950 8553 79499760
Mania 96.70 9.72 185 235890 18075 79490238
Bruxism 95.89 9.72 86 235989 3940 79504373
Rash 95.41 9.72 1175 234900 577183 78931130
Product use in unapproved indication 94.71 9.72 400 235675 249959 79258354
Hepatic function abnormal 94.70 9.72 49 236026 73058 79435255
C-reactive protein increased 91.88 9.72 150 235925 128877 79379436
Disinhibition 87.90 9.72 68 236007 2530 79505783
Libido decreased 87.90 9.72 93 235982 5228 79503085
Acute kidney injury 87.62 9.72 1050 235025 518354 78989959
Orgasmic sensation decreased 86.10 9.72 22 236053 33 79508280
Folliculitis 84.75 9.72 29 236046 55351 79452962
Homicidal ideation 84.63 9.72 75 236000 3382 79504931
Cytomegalovirus infection 83.72 9.72 13 236062 42631 79465682
Exposure via ingestion 82.94 9.72 89 235986 5085 79503228
Discomfort 81.33 9.72 155 235920 125462 79382851
Disease progression 81.08 9.72 277 235798 184085 79324228
Immunodeficiency 81.00 9.72 191 235884 21577 79486736
Anger 77.85 9.72 163 235912 16999 79491314
Mucosal inflammation 77.22 9.72 66 236009 75514 79432799
Blister 76.85 9.72 148 235927 119328 79388985
Pancytopenia 76.34 9.72 244 235831 165501 79342812
Disorientation 76.30 9.72 378 235697 62398 79445915
Erectile dysfunction 75.73 9.72 147 235928 14517 79493796
Peripheral swelling 75.31 9.72 478 235597 269139 79239174
Abdominal discomfort 74.48 9.72 436 235639 250291 79258022
Dyskinesia 74.42 9.72 296 235779 44477 79463836
Depressed level of consciousness 72.75 9.72 513 235562 96139 79412174
Long QT syndrome 72.74 9.72 89 235986 5866 79502447
Mood swings 72.42 9.72 173 235902 19707 79488606
Alcoholism 72.29 9.72 71 236004 3652 79504661
Platelet count decreased 71.77 9.72 314 235761 194350 79313963
Psychomotor retardation 71.65 9.72 90 235985 6094 79502219
C-reactive protein abnormal 71.17 9.72 27 236048 48340 79459973
Contraindicated product administered 70.42 9.72 235 235840 157303 79351010
Inappropriate antidiuretic hormone secretion 70.33 9.72 204 235871 26109 79482204
Galactorrhoea 69.81 9.72 69 236006 3577 79504736
Intrusive thoughts 69.45 9.72 33 236042 491 79507822
Tachyphrenia 69.41 9.72 54 236021 2026 79506287
Impulsive behaviour 69.17 9.72 62 236013 2838 79505475
Myelosuppression 67.27 9.72 18 236057 40278 79468035
Psychomotor hyperactivity 67.27 9.72 152 235923 16697 79491616
Disturbance in sexual arousal 67.18 9.72 26 236049 225 79508088
Multiple organ dysfunction syndrome 65.73 9.72 163 235912 120083 79388230
Bradyphrenia 65.44 9.72 115 235960 10525 79497788
Generalised tonic-clonic seizure 64.89 9.72 280 235795 43630 79464683
Irritable bowel syndrome 64.02 9.72 54 236021 62187 79446126
Thrombocytopenia 63.42 9.72 492 235583 264767 79243546
Swelling 62.16 9.72 381 235694 216330 79291983
Sexual dysfunction 61.40 9.72 94 235981 7669 79500644
Cardiac failure 61.27 9.72 243 235832 154599 79353714
Fibromyalgia 61.20 9.72 60 236015 64280 79444033
Intentional product use issue 58.75 9.72 241 235834 151871 79356442
Impaired healing 58.64 9.72 106 235969 87549 79420764
Cytokine release syndrome 58.38 9.72 17 236058 35981 79472332
Sepsis 58.37 9.72 513 235562 268915 79239398
Psoriatic arthropathy 58.06 9.72 88 235987 77911 79430402
Self-injurious ideation 57.30 9.72 62 236013 3576 79504737
Hallucination, auditory 56.82 9.72 162 235913 20531 79487782
Hallucination, visual 56.51 9.72 219 235856 32510 79475803
Memory impairment 56.03 9.72 541 235534 111193 79397120
Alcohol use 55.48 9.72 70 236005 4761 79503552
Drug dependence 54.99 9.72 253 235822 40516 79467797
Sinusitis 54.88 9.72 346 235729 195155 79313158
Parkinsonism 54.77 9.72 139 235936 16445 79491868
Ill-defined disorder 54.36 9.72 69 236006 65806 79442507
Homicide 53.65 9.72 37 236038 1149 79507164
Drug resistance 53.63 9.72 29 236046 42184 79466129
Dizziness 52.85 9.72 1980 234095 524461 78983852
Drug screen positive 51.64 9.72 76 235999 5987 79502326
Clonus 51.55 9.72 81 235994 6759 79501554
Haematemesis 51.44 9.72 297 235778 51967 79456346
Amnesia 51.18 9.72 341 235734 62716 79445597
Yawning 51.18 9.72 38 236037 1328 79506985
Medication error 50.87 9.72 363 235712 68279 79440034
Thinking abnormal 50.63 9.72 117 235958 13044 79495269
Myocardial stunning 50.51 9.72 20 236055 185 79508128
Negative thoughts 50.37 9.72 38 236037 1361 79506952
Renal impairment 50.30 9.72 268 235807 157515 79350798
Arthralgia 50.16 9.72 1299 234776 570504 78937809
Liver disorder 49.86 9.72 86 235989 72331 79435982
Mental disorder 49.67 9.72 204 235871 31098 79477215
Haemophagocytic lymphohistiocytosis 49.52 9.72 4 236071 21833 79486480
Mental impairment 49.36 9.72 146 235929 18890 79489423
Maternal exposure during pregnancy 49.24 9.72 222 235853 136316 79371997
Insomnia 49.05 9.72 1008 235067 244162 79264151
Lethargy 48.63 9.72 409 235666 80883 79427430
Product use issue 48.36 9.72 393 235682 209429 79298884
Hepatic enzyme increased 48.31 9.72 329 235746 182281 79326032
Bradykinesia 48.26 9.72 86 235989 7957 79500356
Pneumocystis jirovecii pneumonia 48.07 9.72 18 236057 32490 79475823
Abnormal dreams 47.86 9.72 105 235970 11307 79497006
Antipsychotic drug level below therapeutic 47.65 9.72 35 236040 1203 79507110
Genital hypoaesthesia 47.40 9.72 19 236056 182 79508131
Bursitis 47.28 9.72 221 235854 35623 79472690
Cerebral vasoconstriction 46.55 9.72 37 236038 1433 79506880
Knee arthroplasty 46.37 9.72 36 236039 43212 79465101
Rhinitis perennial 46.02 9.72 22 236053 332 79507981
Asphyxia 45.98 9.72 105 235970 11615 79496698
Labelled drug-drug interaction issue 45.67 9.72 36 236039 1377 79506936
Physical assault 45.64 9.72 38 236037 1573 79506740
Nasopharyngitis 45.12 9.72 507 235568 253374 79254939
Lower respiratory tract infection 44.88 9.72 213 235862 129007 79379306
Sedation 44.78 9.72 285 235790 51610 79456703
Toxicologic test abnormal 44.72 9.72 35 236040 1325 79506988
Increased appetite 44.45 9.72 105 235970 11873 79496440
Alcohol abuse 43.92 9.72 66 236009 5297 79503016
Anaemia 43.64 9.72 994 235081 444021 79064292
Rheumatic fever 43.54 9.72 15 236060 28510 79479803
Pleural effusion 42.89 9.72 253 235822 145009 79363304
Dyspnoea 42.76 9.72 2088 233987 854937 78653376
Drug reaction with eosinophilia and systemic symptoms 42.69 9.72 78 235997 64166 79444147
Dissociation 42.62 9.72 56 236019 3965 79504348
Blood cholesterol increased 41.57 9.72 119 235956 83601 79424712
Premature ejaculation 40.65 9.72 13 236062 59 79508254
Abnormal behaviour 40.54 9.72 214 235861 36207 79472106
Panic reaction 40.49 9.72 59 236016 4606 79503707
Coma 40.43 9.72 466 235609 100183 79408130
Major depression 40.39 9.72 85 235990 8895 79499418
Cardiac failure congestive 39.96 9.72 252 235823 142150 79366163
Bone marrow failure 39.66 9.72 56 236019 51051 79457262
Reversible cerebral vasoconstriction syndrome 39.48 9.72 47 236028 3010 79505303
Concussion 39.36 9.72 87 235988 9416 79498897
Hip arthroplasty 39.32 9.72 29 236046 35727 79472586
Syncope 39.30 9.72 748 235327 178701 79329612
Neuropathy peripheral 39.17 9.72 251 235824 141054 79367259
Bronchopulmonary aspergillosis 39.07 9.72 9 236066 22285 79486028
Nicotine dependence 39.03 9.72 28 236047 927 79507386
Atrial fibrillation 38.88 9.72 386 235689 197500 79310813
Angle closure glaucoma 38.84 9.72 46 236029 2930 79505383
Bradycardia 38.38 9.72 589 235486 134968 79373345
Rib deformity 38.10 9.72 17 236058 217 79508096
Antidepressant drug level above therapeutic 37.63 9.72 24 236051 652 79507661
Hyperprolactinaemia 37.52 9.72 57 236018 4619 79503694
Suicidal behaviour 37.21 9.72 47 236028 3200 79505113
Ascites 37.08 9.72 108 235967 75454 79432859
Renal failure 37.03 9.72 398 235677 200570 79307743
Euphoric mood 36.95 9.72 75 236000 7651 79500662
Diarrhoea 36.84 9.72 2183 233892 878306 78630007
Somnambulism 36.70 9.72 63 236012 5658 79502655
Rash erythematous 36.34 9.72 294 235781 57475 79450838
Urinary retention 36.06 9.72 289 235786 56341 79451972
Tachycardia 35.90 9.72 732 235343 177036 79331277
Substance abuse 35.57 9.72 89 235986 10437 79497876
Adrenal insufficiency 35.56 9.72 20 236055 28467 79479846
Hypertonia 35.53 9.72 71 236004 7161 79501152
Acute myeloid leukaemia 35.34 9.72 24 236051 30861 79477452
Haematotoxicity 34.76 9.72 3 236072 15516 79492797
Logorrhoea 34.73 9.72 53 236022 4312 79504001
Pneumonitis 34.44 9.72 81 235994 60779 79447534
Apathy 34.09 9.72 100 235975 12877 79495436
Crying 34.09 9.72 147 235928 22896 79485417
Catatonia 33.86 9.72 78 235997 8678 79499635
Calcium deficiency 33.66 9.72 25 236050 874 79507439
Hyperventilation 33.49 9.72 73 236002 7826 79500487
Toxic epidermal necrolysis 33.46 9.72 50 236025 44531 79463782
Illness anxiety disorder 33.26 9.72 16 236059 245 79508068
Red blood cell sedimentation rate increased 33.07 9.72 53 236022 45889 79462424
COVID-19 32.90 9.72 303 235772 157371 79350942
Prostate cancer 32.84 9.72 30 236045 33238 79475075
Parathyroid gland enlargement 32.83 9.72 14 236061 159 79508154
Rheumatoid nodule 32.72 9.72 6 236069 17432 79490881
Condition aggravated 32.70 9.72 1184 234891 499940 79008373
Product prescribing error 32.63 9.72 236 235839 44577 79463736
Neoplasm progression 32.37 9.72 65 236010 51617 79456696
Tic 32.30 9.72 42 236033 2944 79505369
Drug eruption 32.28 9.72 50 236025 43885 79464428
Tardive dyskinesia 32.24 9.72 86 235989 10485 79497828
Oedema peripheral 31.83 9.72 540 235535 251748 79256565
Aspartate aminotransferase increased 31.78 9.72 260 235815 138381 79369932
Forced expiratory volume 31.72 9.72 12 236063 97 79508216
Extrapyramidal disorder 31.52 9.72 142 235933 22537 79485776
Palmar-plantar erythrodysaesthesia syndrome 31.39 9.72 31 236044 33103 79475210
Hepatic cytolysis 31.20 9.72 21 236054 27130 79481183
Tumour lysis syndrome 31.06 9.72 16 236059 23923 79484390
Rabbit syndrome 31.02 9.72 17 236058 346 79507967
Blood bilirubin increased 30.83 9.72 97 235978 66135 79442178
Hostility 30.63 9.72 36 236039 2274 79506039
Pulseless electrical activity 30.63 9.72 102 235973 14058 79494255
Bladder cancer 30.27 9.72 10 236065 19516 79488797
Premature delivery 29.98 9.72 16 236059 23451 79484862
Hyponatraemic syndrome 29.90 9.72 22 236053 758 79507555
Restless legs syndrome 29.59 9.72 128 235947 19964 79488349
Alcohol poisoning 29.51 9.72 52 236023 4769 79503544
Female sexual arousal disorder 29.46 9.72 7 236068 6 79508307
Spontaneous penile erection 29.40 9.72 12 236063 121 79508192
Blood creatinine increased 29.40 9.72 305 235770 154752 79353561
Emotional distress 29.39 9.72 211 235864 39758 79468555
Derealisation 29.35 9.72 30 236045 1619 79506694
Eosinophilia 29.29 9.72 56 236019 45289 79463024
Neutrophil count decreased 29.15 9.72 161 235914 93798 79414515
Myelodysplastic syndrome 29.11 9.72 28 236047 30273 79478040
Circulatory collapse 28.95 9.72 201 235874 37467 79470846
Arthritis 28.88 9.72 210 235865 114670 79393643
Post viral fatigue syndrome 28.87 9.72 16 236059 333 79507980
Obsessive thoughts 28.59 9.72 25 236050 1107 79507206
Musculoskeletal stiffness 28.57 9.72 356 235719 174652 79333661
Thrombotic microangiopathy 28.46 9.72 12 236063 20157 79488156
Myocardial fibrosis 28.33 9.72 30 236045 1688 79506625
Neonatal infection 28.09 9.72 8 236067 22 79508291
Posterior reversible encephalopathy syndrome 28.02 9.72 22 236053 26259 79482054
Poverty of speech 27.98 9.72 19 236056 575 79507738
Nervousness 27.90 9.72 182 235893 33233 79475080
Alcohol interaction 27.82 9.72 51 236024 4823 79503490
Mental status changes 27.78 9.72 312 235763 66647 79441666
Drug tolerance decreased 27.77 9.72 3 236072 12975 79495338
Skin ulcer 27.60 9.72 76 235999 54074 79454239
Antidepressant drug level increased 27.55 9.72 17 236058 435 79507878
Therapeutic product effect incomplete 27.52 9.72 277 235798 141368 79366945
Flat affect 27.39 9.72 32 236043 2009 79506304
Postmortem blood drug level increased 26.99 9.72 21 236054 788 79507525
Dementia 26.84 9.72 144 235931 24515 79483798
Dystonia 26.81 9.72 130 235945 21269 79487044
Hypersensitivity 26.73 9.72 582 235493 261657 79246656
Liver function test increased 26.68 9.72 48 236027 39725 79468588
Sinus tachycardia 26.65 9.72 194 235881 36714 79471599
Drug hypersensitivity 26.42 9.72 678 235397 298238 79210075
Hypokinesia 26.23 9.72 119 235956 18941 79489372
COVID-19 pneumonia 26.19 9.72 28 236047 28821 79479492
Obesity 26.16 9.72 186 235889 34939 79473374
Hypercalcaemia 26.12 9.72 46 236029 38384 79469929
Speech disorder 26.00 9.72 261 235814 54184 79454129
Haematuria 25.98 9.72 110 235965 68726 79439587
Incoherent 25.95 9.72 65 236010 7627 79500686
Gun shot wound 25.92 9.72 24 236051 1146 79507167
Cytopenia 25.89 9.72 14 236061 20369 79487944
Cholecystitis chronic 25.70 9.72 76 235999 9830 79498483
Orgasm abnormal 25.59 9.72 12 236063 173 79508140
Carcinoid heart disease 25.40 9.72 9 236066 59 79508254
Respiratory distress 25.39 9.72 88 235987 58251 79450062
Enterocolitis 25.15 9.72 6 236069 14506 79493807
Brain injury 24.94 9.72 83 235992 11434 79496879
Osteonecrosis of jaw 24.88 9.72 57 236018 43169 79465144
Polyhydramnios 24.82 9.72 28 236047 1692 79506621
Radiologically isolated syndrome 24.81 9.72 6 236069 6 79508307
Pathogen resistance 24.72 9.72 6 236069 14336 79493977
Sexually inappropriate behaviour 24.65 9.72 17 236058 528 79507785
Libido increased 24.59 9.72 30 236045 1971 79506342
Prescribed overdose 24.48 9.72 194 235881 37689 79470624
Lactic acidosis 24.41 9.72 116 235959 70243 79438070
Failure to suspend medication 24.35 9.72 16 236059 458 79507855
Pseudomonas infection 24.24 9.72 16 236059 20887 79487426
Blood uric acid increased 24.21 9.72 5 236070 13355 79494958
Neuroleptic malignant syndrome 24.18 9.72 152 235923 27407 79480906
Tension 23.79 9.72 45 236030 4359 79503954
Transplant rejection 23.76 9.72 14 236061 19423 79488890
White blood cell count decreased 23.74 9.72 403 235672 187885 79320428
Dysarthria 23.63 9.72 305 235770 67317 79440996
Optic ischaemic neuropathy 23.62 9.72 36 236039 2925 79505388
Dissociative amnesia 23.57 9.72 10 236065 112 79508201
Urticaria 23.48 9.72 396 235679 184805 79323508
Delusion 23.42 9.72 121 235954 20302 79488011
Panic disorder 23.34 9.72 36 236039 2956 79505357
Upper respiratory fungal infection 23.30 9.72 14 236061 341 79507972
Atonic urinary bladder 23.24 9.72 9 236066 78 79508235
Dysphemia 23.19 9.72 39 236036 3445 79504868
Neuropathy, ataxia, retinitis pigmentosa syndrome 23.18 9.72 8 236067 48 79508265
Injection site pain 23.16 9.72 259 235816 129579 79378734
Bipolar I disorder 23.11 9.72 30 236045 2099 79506214
Cognitive disorder 23.03 9.72 312 235763 69614 79438699
Anhidrosis 23.01 9.72 12 236063 220 79508093
Drug-induced liver injury 22.94 9.72 109 235966 66008 79442305
Skin swelling 22.91 9.72 42 236033 3972 79504341
Therapeutic product effect variable 22.89 9.72 29 236046 1980 79506333
Rash maculo-papular 22.81 9.72 87 235988 55991 79452322
Bipolar disorder 22.80 9.72 62 236013 7645 79500668
Sebaceous gland infection 22.72 9.72 11 236064 171 79508142
Vertigo 22.65 9.72 308 235767 68774 79439539
Hypomania 22.63 9.72 61 236014 7483 79500830
Hypersomnia 22.59 9.72 131 235944 22955 79485358
Prescription drug used without a prescription 22.39 9.72 42 236033 4043 79504270
Dreamy state 22.26 9.72 8 236067 55 79508258
Psychiatric symptom 22.23 9.72 58 236017 6977 79501336
Venoocclusive liver disease 22.19 9.72 4 236071 11767 79496546
Social avoidant behaviour 22.16 9.72 46 236029 4768 79503545
Hypochloraemia 22.11 9.72 32 236043 2483 79505830
Gestational diabetes 22.10 9.72 54 236021 6239 79502074
Antipsychotic drug level above therapeutic 22.10 9.72 29 236046 2051 79506262
Oedema 21.94 9.72 237 235838 119343 79388970
Red blood cell sedimentation rate abnormal 21.78 9.72 18 236057 20945 79487368
Personality change 21.77 9.72 73 236002 10097 79498216
Aplastic anaemia 21.74 9.72 13 236062 17892 79490421
Disseminated intravascular coagulation 21.67 9.72 46 236029 35796 79472517
Herpes zoster 21.59 9.72 174 235901 92909 79415404
Respiratory tract infection 21.49 9.72 73 236002 48616 79459697
Foetal chromosome abnormality 21.48 9.72 6 236069 15 79508298
Myocardial infarction 21.34 9.72 400 235675 183729 79324584
Schizoaffective disorder 21.32 9.72 29 236046 2123 79506190
Polyneuropathy 21.30 9.72 24 236051 24127 79484186
Epstein-Barr virus infection 21.29 9.72 8 236067 14408 79493905
Swollen tongue 21.27 9.72 206 235869 42364 79465949
Sputum purulent 21.26 9.72 23 236052 1326 79506987
Hypogammaglobulinaemia 21.21 9.72 6 236069 12945 79495368
Neonatal seizure 21.20 9.72 5 236070 4 79508309
Drug ineffective for unapproved indication 21.16 9.72 79 235996 51159 79457154
Muscle tightness 21.15 9.72 85 235990 12829 79495484
Pulmonary toxicity 21.12 9.72 6 236069 12908 79495405
Adverse event 21.05 9.72 99 235976 60115 79448198
Bronchomalacia 21.02 9.72 12 236063 265 79508048
Vascular access site thrombosis 21.02 9.72 7 236068 37 79508276
CFTR gene mutation 20.89 9.72 9 236066 105 79508208
Abnormal weight gain 20.89 9.72 32 236043 2612 79505701
Activation syndrome 20.70 9.72 12 236063 273 79508040
Hypocalcaemia 20.60 9.72 77 235998 49847 79458466
Pruritus 20.48 9.72 957 235118 393691 79114622
Poor quality sleep 20.35 9.72 126 235949 22596 79485717
Delirium 20.34 9.72 358 235717 84269 79424044
Pupillary reflex impaired 20.31 9.72 36 236039 3317 79504996
Therapy non-responder 20.29 9.72 175 235900 92130 79416183
Bone erosion 20.24 9.72 14 236061 17833 79490480
Diaphragmatic rupture 20.24 9.72 11 236064 220 79508093
Hyperuricaemia 20.21 9.72 5 236070 11794 79496519
Foetal death 20.19 9.72 61 236014 7983 79500330
Gastrointestinal disorder 20.16 9.72 248 235827 121957 79386356
Pulmonary arterial hypertension 20.16 9.72 33 236042 28333 79479980
Alanine aminotransferase increased 20.15 9.72 349 235726 162221 79346092
Lung disorder 19.89 9.72 148 235927 80409 79427904
Interstitial granulomatous dermatitis 19.76 9.72 11 236064 231 79508082
Histrionic personality disorder 19.74 9.72 7 236068 46 79508267
Chronic sinusitis 19.62 9.72 7 236068 13019 79495294
Tinnitus 19.50 9.72 209 235866 44124 79464189
Gender dysphoria 19.37 9.72 7 236068 49 79508264
Pulmonary alveolar haemorrhage 19.35 9.72 5 236070 11452 79496861
Neuroglycopenia 19.35 9.72 14 236061 470 79507843
Spermatozoa morphology abnormal 19.30 9.72 4 236071 0 79508313
Sexual inhibition 19.30 9.72 4 236071 0 79508313
Nocturnal emission 19.30 9.72 4 236071 0 79508313
Agoraphobia 19.28 9.72 15 236060 563 79507750
Acute myocardial infarction 19.28 9.72 141 235934 76895 79431418
Dermatitis bullous 19.27 9.72 9 236066 14236 79494077
Facial spasm 19.23 9.72 17 236058 764 79507549
Opiates positive 19.22 9.72 19 236056 985 79507328
Orthostatic intolerance 19.17 9.72 26 236049 1898 79506415
Therapy interrupted 19.13 9.72 40 236035 31301 79477012
Cytomegalovirus viraemia 19.12 9.72 7 236068 12814 79495499
Self-medication 19.06 9.72 45 236030 5087 79503226
Decreased interest 19.02 9.72 37 236038 3660 79504653
Cholangitis 19.02 9.72 7 236068 12769 79495544
Intestinal congestion 19.01 9.72 5 236070 9 79508304
Hypoalbuminaemia 18.97 9.72 21 236054 21276 79487037
Acute generalised exanthematous pustulosis 18.96 9.72 14 236061 17240 79491073
Macular degeneration 18.94 9.72 5 236070 11291 79497022
Hyperbilirubinaemia 18.89 9.72 27 236048 24491 79483822
Autoimmune disorder 18.88 9.72 13 236062 16599 79491714
Menopause 18.85 9.72 27 236048 2075 79506238
Conduction disorder 18.84 9.72 35 236040 3344 79504969
Head injury 18.75 9.72 181 235894 37188 79471125
Pulmonary oedema 18.67 9.72 366 235709 87888 79420425
Loss of bladder sensation 18.59 9.72 8 236067 93 79508220
Blood alcohol increased 18.55 9.72 21 236054 1274 79507039
Ventricular arrhythmia 18.52 9.72 63 236012 8777 79499536
Fear 18.51 9.72 120 235955 21866 79486447
Heat stroke 18.49 9.72 24 236051 1679 79506634
Drug abuser 18.42 9.72 49 236026 5964 79502349
Product dose omission issue 18.42 9.72 575 235500 246962 79261351
Pneumonia bacterial 18.41 9.72 18 236057 19313 79489000
Cerebrospinal fluid retention 18.37 9.72 8 236067 96 79508217
Libido disorder 18.27 9.72 11 236064 269 79508044
Metastases to liver 18.26 9.72 35 236040 28279 79480034
Genital anaesthesia 18.04 9.72 5 236070 12 79508301
Panniculitis 18.04 9.72 7 236068 12364 79495949
Hospitalisation 18.00 9.72 185 235890 94051 79414262
Therapy partial responder 18.00 9.72 15 236060 17382 79490931
Basal ganglion degeneration 18 9.72 13 236062 435 79507878
Mobility decreased 17.94 9.72 254 235821 121921 79386392
Cataract 17.90 9.72 109 235966 62011 79446302
Pain 17.84 9.72 1818 234257 701984 78806329
Subclavian artery thrombosis 17.82 9.72 6 236069 33 79508280
Hanging 17.82 9.72 9 236066 154 79508159
Influenza 17.80 9.72 273 235802 129333 79378980
Sexual relationship change 17.76 9.72 5 236070 13 79508300
Sternal fracture 17.75 9.72 29 236046 2501 79505812
Semen volume decreased 17.75 9.72 7 236068 64 79508249
Antipsychotic drug level increased 17.70 9.72 48 236027 5909 79502404
Bacteraemia 17.54 9.72 45 236030 32779 79475534
Post-traumatic neck syndrome 17.48 9.72 26 236049 2068 79506245
Drug withdrawal syndrome neonatal 17.47 9.72 11 236064 292 79508021
Atrophic vulvovaginitis 17.30 9.72 20 236055 1241 79507072
Mood altered 17.28 9.72 101 235974 17746 79490567
Ejection fraction decreased 17.27 9.72 49 236026 34528 79473785
Amputation stump pain 17.25 9.72 6 236069 37 79508276
CYP3A4 polymorphism 17.20 9.72 7 236068 70 79508243
Hypersexuality 17.20 9.72 23 236052 1657 79506656
Feeling abnormal 17.18 9.72 604 235471 158595 79349718
Cystoid macular oedema 17.12 9.72 25 236050 1955 79506358
Electrolyte substitution therapy 17.07 9.72 4 236071 3 79508310
Legal problem 17.07 9.72 9 236066 169 79508144
Meningitis streptococcal 17.07 9.72 9 236066 169 79508144
Incontinence 17.00 9.72 85 235990 14079 79494234
Lymphoma 16.93 9.72 16 236059 17444 79490869
Morbid thoughts 16.90 9.72 16 236059 786 79507527
Musculoskeletal pain 16.77 9.72 208 235867 102146 79406167
Graft versus host disease 16.76 9.72 12 236063 15014 79493299
Personality disorder 16.76 9.72 48 236027 6098 79502215
Multiple sclerosis relapse 16.73 9.72 211 235864 46322 79461991
Hypokalaemia 16.68 9.72 551 235524 143489 79364824
Thrombosis 16.52 9.72 164 235911 83936 79424377
Basal cell carcinoma 16.52 9.72 56 236019 37319 79470994
Respiratory depression 16.51 9.72 139 235936 27491 79480822
Hepatotoxicity 16.48 9.72 87 235988 51265 79457048
Persistent depressive disorder 16.35 9.72 19 236056 1186 79507127
Kidney transplant rejection 16.32 9.72 5 236070 10241 79498072
Caesarean section 16.32 9.72 77 235998 12458 79495855
Ventricular tachycardia 16.32 9.72 193 235882 41742 79466571
Organising pneumonia 16.27 9.72 6 236069 10933 79497380
Cough 16.23 9.72 904 235171 365885 79142428
Violence-related symptom 16.21 9.72 15 236060 716 79507597
Soft tissue injury 16.15 9.72 23 236052 1758 79506555
Nystagmus 16.07 9.72 65 236010 9839 79498474
Hypoglycaemia 16.00 9.72 404 235671 101190 79407123
Therapeutic response decreased 15.95 9.72 124 235951 66729 79441584
Accidental poisoning 15.92 9.72 22 236053 1635 79506678
Polymenorrhagia 15.91 9.72 6 236069 48 79508265
Acute respiratory failure 15.87 9.72 107 235968 59434 79448879
Balance disorder 15.84 9.72 394 235681 98463 79409850
Stress 15.78 9.72 327 235748 79285 79429028
Toxic skin eruption 15.78 9.72 26 236049 22267 79486046
Parkinson's disease 15.78 9.72 22 236053 1649 79506664
Throat irritation 15.72 9.72 65 236010 40881 79467432
Mucormycosis 15.70 9.72 3 236072 8466 79499847
Cardiac steatosis 15.70 9.72 6 236069 50 79508263
Adenovirus infection 15.65 9.72 3 236072 8444 79499869
Chronic kidney disease 15.64 9.72 123 235952 66031 79442282
Burns second degree 15.64 9.72 28 236047 2600 79505713
Epistaxis 15.61 9.72 234 235841 111281 79397032
Fluid retention 15.61 9.72 292 235783 69517 79438796
Drug level above therapeutic 15.58 9.72 59 236016 8664 79499649
Cystitis haemorrhagic 15.49 9.72 4 236071 9168 79499145
Bronchitis 15.39 9.72 283 235792 130361 79377952
Stupor 15.31 9.72 50 236025 6822 79501491
Skin toxicity 15.30 9.72 3 236072 8311 79500002
Dermatillomania 15.29 9.72 9 236066 211 79508102
Adjustment disorder with depressed mood 15.28 9.72 4 236071 9082 79499231
Dysponesis 15.28 9.72 4 236071 7 79508306
Uterine enlargement 15.23 9.72 16 236059 892 79507421
Lipoedema 15.21 9.72 9 236066 213 79508100
Hallucinations, mixed 15.19 9.72 50 236025 6849 79501464
Right ventricular failure 15.19 9.72 29 236046 23468 79484845
Disability 15.11 9.72 17 236058 17103 79491210
Hepatocellular carcinoma 15.11 9.72 4 236071 9017 79499296
Sensory disturbance 15.04 9.72 86 235989 14991 79493322
Posturing 14.95 9.72 17 236058 1036 79507277
Dysphoria 14.93 9.72 39 236036 4695 79503618
Anticholinergic syndrome 14.89 9.72 33 236042 3578 79504735
Coordination abnormal 14.88 9.72 95 235980 17217 79491096
Hyperkinesia 14.88 9.72 28 236047 2701 79505612
Aspergillus infection 14.86 9.72 21 236054 19140 79489173
Renal disorder 14.85 9.72 69 236006 42036 79466277
Proteinuria 14.84 9.72 48 236027 32454 79475859
Adjustment disorder 14.77 9.72 35 236040 3965 79504348
Vasoplegia syndrome 14.77 9.72 33 236042 3597 79504716
End stage renal disease 14.66 9.72 9 236066 12211 79496102
Blunted affect 14.66 9.72 12 236063 485 79507828
Female orgasmic disorder 14.63 9.72 5 236070 29 79508284
Ankylosing spondylitis 14.62 9.72 9 236066 12196 79496117
Hypervigilance 14.61 9.72 12 236063 487 79507826
Agranulocytosis 14.61 9.72 76 235999 44954 79463359
Wrong product administered 14.51 9.72 59 236016 8953 79499360
New daily persistent headache 14.48 9.72 3 236072 0 79508313
Gas poisoning 14.48 9.72 3 236072 0 79508313
Intervertebral disc disorder 14.46 9.72 39 236036 4786 79503527
Product storage error 14.45 9.72 16 236059 16210 79492103
Dysaesthesia 14.36 9.72 44 236031 5804 79502509
Multiple sclerosis 14.34 9.72 114 235961 22168 79486145
Trismus 14.24 9.72 42 236033 5425 79502888
Feeling of despair 14.23 9.72 28 236047 2793 79505520
Localised infection 14.20 9.72 60 236015 37515 79470798
Colorectal cancer 14.18 9.72 4 236071 8643 79499670
Initial insomnia 14.15 9.72 49 236026 6889 79501424
Appendicitis 14.03 9.72 25 236050 20769 79487544
Metastases to lung 13.99 9.72 20 236055 18143 79490170
Vertigo CNS origin 13.96 9.72 5 236070 34 79508279
Joint range of motion decreased 13.95 9.72 51 236024 33231 79475082
Self esteem decreased 13.93 9.72 16 236059 986 79507327
Tobacco user 13.86 9.72 14 236061 745 79507568
Job dissatisfaction 13.85 9.72 6 236069 71 79508242
Meconium in amniotic fluid 13.85 9.72 7 236068 120 79508193
Injection site reaction 13.84 9.72 100 235975 54685 79453628
Wrong technique in product usage process 13.71 9.72 146 235929 73729 79434584
Acute stress disorder 13.68 9.72 11 236064 433 79507880
Vascular access site infection 13.64 9.72 7 236068 124 79508189
Acute graft versus host disease in skin 13.60 9.72 3 236072 7655 79500658
Creatinine renal clearance decreased 13.60 9.72 22 236053 18980 79489333
Haematospermia 13.59 9.72 9 236066 261 79508052
Differential white blood cell count abnormal 13.49 9.72 23 236052 2054 79506259
Product administration error 13.48 9.72 149 235926 31697 79476616
Anaphylactic reaction 13.41 9.72 171 235904 83572 79424741
Melaena 13.38 9.72 254 235821 60636 79447677
Heterophoria 13.37 9.72 5 236070 39 79508274
Renal cancer 13.33 9.72 10 236065 12216 79496097
Blood catecholamines decreased 13.33 9.72 4 236071 14 79508299
Haemolysis 13.31 9.72 11 236064 12801 79495512
Heparin-induced thrombocytopenia 13.28 9.72 6 236069 9676 79498637
Multiple drug therapy 13.28 9.72 34 236041 4044 79504269
Economic problem 13.27 9.72 24 236051 2246 79506067
Arrhythmia 13.26 9.72 255 235820 61017 79447296
Asthma 13.22 9.72 507 235568 134588 79373725
Cholestasis 13.22 9.72 95 235980 52014 79456299
Testicular atrophy 13.19 9.72 10 236065 361 79507952
Vaginal haemorrhage 13.16 9.72 110 235965 21707 79486606
Tissue infiltration 13.09 9.72 13 236062 678 79507635
Suspected suicide 13.07 9.72 64 236011 10512 79497801
Pyelonephritis chronic 12.98 9.72 9 236066 282 79508031
Cushingoid 12.98 9.72 6 236069 9546 79498767
Myositis 12.98 9.72 23 236052 19145 79489168
Congestive hepatopathy 12.88 9.72 36 236039 4511 79503802
Potentiating drug interaction 12.84 9.72 56 236019 8763 79499550
Gastrointestinal toxicity 12.84 9.72 4 236071 8105 79500208
Systolic hypertension 12.82 9.72 13 236062 695 79507618
Executive dysfunction 12.70 9.72 9 236066 292 79508021
Catarrh 12.70 9.72 23 236052 2155 79506158
Anaphylactic shock 12.69 9.72 59 236016 35937 79472376
Fibrous histiocytoma 12.65 9.72 13 236062 706 79507607
Ocular hyperaemia 12.64 9.72 42 236033 28164 79480149
Osteoporosis 12.61 9.72 101 235974 54011 79454302
Jaundice cholestatic 12.60 9.72 9 236066 11275 79497038
Hepatitis fulminant 12.59 9.72 3 236072 7259 79501054
Marital problem 12.59 9.72 8 236067 216 79508097
Facial paralysis 12.58 9.72 106 235969 20966 79487347
Hyperthermia 12.56 9.72 94 235981 17943 79490370
Adjusted calcium decreased 12.55 9.72 8 236067 217 79508096
Saliva altered 12.54 9.72 11 236064 489 79507824
Adrenergic syndrome 12.53 9.72 7 236068 148 79508165
Oliguria 12.52 9.72 18 236057 16291 79492022
Mutism 12.52 9.72 24 236051 2348 79505965
Pregnancy 12.47 9.72 128 235947 26723 79481590
Tuberculosis 12.45 9.72 16 236059 15182 79493131
Bisexuality 12.41 9.72 3 236072 3 79508310
Cervix haematoma uterine 12.41 9.72 3 236072 3 79508310
Antidepressant drug level below therapeutic 12.41 9.72 3 236072 3 79508310
Cardiac death 12.37 9.72 19 236056 1555 79506758
Cholecystectomy 12.32 9.72 58 236017 9374 79498939
Feeling guilty 12.30 9.72 14 236061 854 79507459
Cellulitis 12.30 9.72 238 235837 108822 79399491
Cardiac failure chronic 12.28 9.72 9 236066 11126 79497187
Respiratory disorder 12.26 9.72 80 235995 44776 79463537
Post-traumatic stress disorder 12.24 9.72 37 236038 4844 79503469
Movement disorder 12.22 9.72 129 235946 27130 79481183
Social problem 12.21 9.72 18 236057 1420 79506893
Peripheral circulatory failure 12.21 9.72 16 236059 1130 79507183
Electrocardiogram QT interval abnormal 12.21 9.72 9 236066 311 79508002
Gastrointestinal mucosal exfoliation 12.20 9.72 8 236067 228 79508085
Osmolar gap abnormal 12.18 9.72 6 236069 97 79508216
Pleurisy 12.17 9.72 8 236067 10467 79497846
Stiff person syndrome 12.16 9.72 9 236066 313 79508000
Hepatitis C virus test positive 12.15 9.72 10 236065 407 79507906
Azoospermia 12.13 9.72 7 236068 158 79508155
Pneumonia viral 12.06 9.72 6 236069 9152 79499161
Psychogenic seizure 12.04 9.72 21 236054 1910 79506403
Diffuse large B-cell lymphoma stage II 12.02 9.72 6 236069 100 79508213
Cardiomegaly 11.95 9.72 125 235950 26227 79482086
Nephropathy 11.92 9.72 7 236068 9731 79498582
Metastases to bone 11.92 9.72 35 236040 24392 79483921
Pulmonary fibrosis 11.89 9.72 79 235996 44033 79464280
Drug level increased 11.88 9.72 174 235901 39477 79468836
Unintentional medical device removal 11.86 9.72 4 236071 7708 79500605
Hepatic steatosis 11.86 9.72 167 235908 37571 79470742
Detoxification 11.81 9.72 6 236069 104 79508209
Blood osmolarity decreased 11.79 9.72 17 236058 1314 79506999
Pelvic fracture 11.78 9.72 69 236006 12135 79496178
Teratogenicity 11.76 9.72 8 236067 243 79508070
Poor personal hygiene 11.75 9.72 11 236064 533 79507780
Peritoneal perforation 11.71 9.72 7 236068 169 79508144
JC virus CSF test positive 11.71 9.72 7 236068 169 79508144
Exposure to allergen 11.70 9.72 9 236066 332 79507981
Injection site erythema 11.68 9.72 162 235913 78035 79430278
Hypoxic-ischaemic encephalopathy 11.65 9.72 50 236025 7770 79500543
Pyelonephritis 11.64 9.72 27 236048 20361 79487952
Colitis 11.63 9.72 150 235925 73157 79435156
Gastrointestinal sounds abnormal 11.62 9.72 39 236036 5396 79502917
Hypocoagulable state 11.59 9.72 22 236053 2137 79506176
Skin laceration 11.58 9.72 134 235941 28828 79479485
Wrong patient received product 11.57 9.72 35 236040 4583 79503730
Osmotic demyelination syndrome 11.52 9.72 18 236057 1495 79506818
Hypertension 11.49 9.72 834 235241 330158 79178155
Spermatozoa progressive motility decreased 11.48 9.72 5 236070 60 79508253
Pneumothorax 11.48 9.72 44 236031 28279 79480034
Bipolar II disorder 11.47 9.72 10 236065 441 79507872
Stoma site infection 11.45 9.72 18 236057 1502 79506811
Bulimia nervosa 11.44 9.72 8 236067 254 79508059
Foot deformity 11.38 9.72 35 236040 24039 79484274
Inflammation 11.38 9.72 202 235873 93551 79414762
Chronic graft versus host disease 11.37 9.72 3 236072 6778 79501535
Drug dose titration not performed 11.37 9.72 13 236062 797 79507516
Tricuspid valve incompetence 11.34 9.72 26 236049 19686 79488627
Male orgasmic disorder 11.33 9.72 5 236070 62 79508251
Peripheral ischaemia 11.29 9.72 7 236068 9450 79498863
Lip swelling 11.28 9.72 177 235898 40734 79467579
Injection site pruritus 11.26 9.72 76 235999 42207 79466106
Blood ethanol increased 11.25 9.72 12 236063 681 79507632
Hypervolaemia 11.23 9.72 77 235998 42613 79465700
Alcoholic psychosis 11.20 9.72 3 236072 6 79508307
Adjusted calcium increased 11.19 9.72 5 236070 64 79508249
Pneumonia fungal 11.19 9.72 10 236065 11200 79497113
Akinesia 11.19 9.72 28 236047 3284 79505029
Hypopnoea 11.18 9.72 38 236037 5291 79503022
Pickwickian syndrome 11.15 9.72 10 236065 458 79507855
Upper respiratory tract infection 11.14 9.72 351 235724 90817 79417496
Hypoxia 11.13 9.72 227 235848 103016 79405297
Product substitution issue 11.11 9.72 100 235975 20156 79488157
Contraindicated product prescribed 11.10 9.72 19 236056 1702 79506611
Frequent bowel movements 11.07 9.72 135 235940 29404 79478909
Decreased appetite 11.06 9.72 868 235207 341550 79166763
Amniorrhexis 10.95 9.72 4 236071 29 79508284
Photosensitivity reaction 10.93 9.72 103 235972 21024 79487289
Heavy menstrual bleeding 10.91 9.72 75 236000 13936 79494377
Cardiac tamponade 10.89 9.72 7 236068 9269 79499044
Accommodation disorder 10.87 9.72 11 236064 587 79507726
Antisocial behaviour 10.86 9.72 12 236063 709 79507604
Benign prostatic hyperplasia 10.84 9.72 11 236064 11601 79496712
Carbon monoxide poisoning 10.84 9.72 8 236067 277 79508036
Miosis 10.84 9.72 82 235993 15707 79492606
Diffuse large B-cell lymphoma 10.80 9.72 12 236063 12137 79496176
Therapy cessation 10.77 9.72 66 236009 37496 79470817
Pancreatitis relapsing 10.76 9.72 14 236061 982 79507331
Parotid gland enlargement 10.74 9.72 14 236061 984 79507329
Dermatitis exfoliative generalised 10.72 9.72 4 236071 7237 79501076
Autoscopy 10.61 9.72 5 236070 73 79508240
Emotional disorder 10.60 9.72 76 235999 14311 79494002
Angiodermatitis 10.55 9.72 5 236070 74 79508239
Atrial flutter 10.54 9.72 31 236044 21594 79486719
Inguinal mass 10.54 9.72 7 236068 204 79508109
Thrombotic stroke 10.46 9.72 12 236063 739 79507574
Subdural haemorrhage 10.43 9.72 40 236035 5908 79502405
Gallbladder disorder 10.36 9.72 95 235980 19245 79489068
Genito-pelvic pain/penetration disorder 10.34 9.72 3 236072 9 79508304
Tendonitis 10.33 9.72 36 236039 23794 79484519
Feeling of body temperature change 10.33 9.72 37 236038 5289 79503024
Extensor plantar response 10.33 9.72 19 236056 1802 79506511
Palpitations 10.31 9.72 466 235609 126144 79382169
Gastrointestinal procedural complication 10.30 9.72 7 236068 212 79508101
Slow response to stimuli 10.30 9.72 19 236056 1806 79506507
Biliary dyskinesia 10.20 9.72 23 236052 2522 79505791
Agonal rhythm 10.20 9.72 5 236070 80 79508233
Joint effusion 10.17 9.72 24 236051 17990 79490323
Coagulation factor increased 10.14 9.72 5 236070 81 79508232
Anaesthesia 10.14 9.72 10 236065 517 79507796
Pupillary light reflex tests abnormal 10.13 9.72 8 236067 307 79508006
Lower limb fracture 10.11 9.72 35 236040 23180 79485133
Scleroedema 10.10 9.72 4 236071 37 79508276
Liver injury 10.06 9.72 113 235962 56501 79451812
Drug dose omission by device 10.05 9.72 3 236072 6247 79502066
Conversion disorder 10.03 9.72 19 236056 1842 79506471
Anhedonia 10.02 9.72 77 235998 14821 79493492
HIV peripheral neuropathy 10.01 9.72 4 236071 38 79508275
Alanine aminotransferase abnormal 10.00 9.72 7 236068 8860 79499453
Borderline personality disorder 9.97 9.72 13 236062 914 79507399
Phlebitis 9.92 9.72 7 236068 8823 79499490
Body dysmorphic disorder 9.91 9.72 8 236067 317 79507996
Maternal exposure during breast feeding 9.89 9.72 24 236051 2761 79505552
Colour blindness 9.88 9.72 9 236066 421 79507892
Polyarthritis 9.84 9.72 13 236062 12189 79496124
Urinary incontinence 9.81 9.72 173 235902 40736 79467577
Reflexes abnormal 9.79 9.72 13 236062 930 79507383
Phobia 9.77 9.72 9 236066 427 79507886
Vitreous floaters 9.76 9.72 45 236030 7211 79501102

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cryptorchism 34.98 29.56 38 1433 371 87950
Respiratory disorder neonatal 34.30 29.56 80 1391 1586 86735

Pharmacologic Action:

SourceCodeDescription
ATC N06AB04 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:50949 SSRI
CHEBI has role CHEBI:76779 post-proline endopeptidase inhibitors
CHEBI has role CHEBI:77402 EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitors
CHEBI has role CHEBI:78298 environmental contaminants
FDA EPC N0000175696 Serotonin Reuptake Inhibitor
MeSH PA D000928 Antidepressive Agents
MeSH PA D018687 Antidepressive Agents, Second-Generation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D017367 Selective Serotonin Reuptake Inhibitors
MeSH PA D018490 Serotonin Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Depressive disorder indication 35489007
Major depressive disorder indication 370143000
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Obsessive-compulsive disorder off-label use 191736004 DOID:10933
Menopausal flushing off-label use 198436008
Panic disorder off-label use 371631005 DOID:594
Suicidal thoughts contraindication 6471006
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Torsades de pointes contraindication 31722008
Upper gastrointestinal hemorrhage contraindication 37372002
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Heart disease contraindication 56265001 DOID:114
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Epilepsy contraindication 84757009 DOID:1826
Hyponatremia contraindication 89627008
Prolonged QT interval contraindication 111975006
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Serotonin syndrome contraindication 371089000
Myocardial infarction in recovery phase contraindication 418044006
Poor metabolizer due to cytochrome p450 CYP2C19 variant contraindication 424500005
Congenital long QT syndrome contraindication 442917000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 8.94 WOMBAT-PK CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.40 WOMBAT-PK
Sodium-dependent noradrenaline transporter Transporter Ki 5.21 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 5.19 PDSP
5-hydroxytryptamine receptor 2B GPCR Ki 5.93 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.21 WOMBAT-PK
Histamine H1 receptor GPCR Ki 6.46 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 5.88 PDSP
Sodium-dependent dopamine transporter Transporter Ki 4.78 CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 6.15 DRUG MATRIX
Acetylcholinesterase Enzyme IC50 4.13 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.73 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.78 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 5.74 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 5.76 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 4.30 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 8.82 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 5.03 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.54 CHEMBL
Transporter Transporter Ki 5.21 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 8.54 CHEMBL
Transporter Transporter Ki 5.23 CHEMBL
Sigma intracellular receptor 2 Unclassified Ki 5.27 CHEMBL

External reference:

IDSource
4021129 VUID
N0000148583 NUI
D00822 KEGG_DRUG
59729-32-7 SECONDARY_CAS_RN
221078 RXNORM
4021129 VANDF
4021130 VANDF
C0008845 UMLSCUI
CHEBI:3723 CHEBI
CHEMBL549 ChEMBL_ID
CHEMBL399730 ChEMBL_ID
DB00215 DRUGBANK_ID
CHEMBL1200781 ChEMBL_ID
D015283 MESH_DESCRIPTOR_UI
2771 PUBCHEM_CID
7547 IUPHAR_LIGAND_ID
4138 INN_ID
0DHU5B8D6V UNII
21814 MMSL
62559 MMSL
7486 MMSL
d04332 MMSL
005106 NDDF
005107 NDDF
116521005 SNOMEDCT_US
321986007 SNOMEDCT_US
372596005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0054-0062 SOLUTION 10 mg ORAL ANDA 27 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0054-0062 SOLUTION 10 mg ORAL ANDA 27 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0054-0062 SOLUTION 10 mg ORAL ANDA 27 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0121-0848 SOLUTION 10 mg ORAL ANDA 32 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0121-1696 SOLUTION 20 mg ORAL ANDA 32 sections
Citalopram Human Prescription Drug Label 1 0185-0371 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Citalopram Human Prescription Drug Label 1 0185-0372 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
Citalopram Human Prescription Drug Label 1 0185-0373 TABLET, FILM COATED 40 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6231 TABLET, FILM COATED 10 mg ORAL ANDA 39 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6231 TABLET, FILM COATED 10 mg ORAL ANDA 39 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6232 TABLET, FILM COATED 20 mg ORAL ANDA 39 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6232 TABLET, FILM COATED 20 mg ORAL ANDA 39 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6233 TABLET, FILM COATED 40 mg ORAL ANDA 39 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6233 TABLET, FILM COATED 40 mg ORAL ANDA 39 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4010 TABLET, FILM COATED 10 mg ORAL NDA 35 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4010 TABLET, FILM COATED 10 mg ORAL NDA 35 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4010 TABLET, FILM COATED 10 mg ORAL NDA 35 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4020 TABLET, FILM COATED 20 mg ORAL NDA 35 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4020 TABLET, FILM COATED 20 mg ORAL NDA 35 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4020 TABLET, FILM COATED 20 mg ORAL NDA 35 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4040 TABLET, FILM COATED 40 mg ORAL NDA 35 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4040 TABLET, FILM COATED 40 mg ORAL NDA 35 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4040 TABLET, FILM COATED 40 mg ORAL NDA 35 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8022 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8022 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8022 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8023 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8023 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8023 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8141 TABLET, FILM COATED 40 mg ORAL ANDA 31 sections