paroxetine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives 2068 61869-08-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • BRL 29060A
  • BRL-29060A
  • paroxetine hydrochloride hydrate
  • brisdelle
  • paroxetine
  • paxetil
  • paxil
  • paroxetine hydrochloride
  • paroxetine mesylate
  • paroxetine hydrochloride hemihydrate
  • paroxetine hydrochloride anhydrous
  • paroxetine mesilate
  • paroxetine HCl
A serotonin uptake inhibitor that is effective in the treatment of depression.
  • Molecular weight: 329.37
  • Formula: C19H20FNO3
  • CLOGP: 4.24
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 39.72
  • ALOGS: -4.59
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 5.40 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.53 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 18 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 18 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.06 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 13 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1992 FDA APOTEX TECHNOLOGIES

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug withdrawal syndrome 2823.05 46.54 639 6821 6182 2344443
Exposure during pregnancy 2251.10 46.54 700 6760 24519 2326106
Suicidal ideation 1940.22 46.54 521 6939 10566 2340059
Atrial septal defect 1787.04 46.54 333 7127 1011 2349614
Completed suicide 1561.46 46.54 509 6951 20525 2330100
Anxiety 1520.04 46.54 542 6918 28817 2321808
Serotonin syndrome 1299.02 46.54 302 7158 3238 2347387
Suicide attempt 1203.18 46.54 361 7099 10921 2339704
Dizziness 1138.01 46.54 536 6924 58129 2292496
Tremor 1121.24 46.54 396 7064 20265 2330360
Toxicity to various agents 1105.23 46.54 443 7017 32311 2318314
Agitation 1068.14 46.54 328 7132 10723 2339902
Ventricular septal defect 1044.88 46.54 196 7264 616 2350009
Depression 1019.77 46.54 401 7059 27731 2322894
Patent ductus arteriosus 1003.37 46.54 184 7276 490 2350135
Insomnia 886.23 46.54 354 7106 25433 2325192
Foetal exposure during pregnancy 863.82 46.54 236 7224 5016 2345609
Intentional self-injury 861.66 46.54 224 7236 3903 2346722
Hyperhidrosis 851.87 46.54 300 7160 15122 2335503
Aggression 847.62 46.54 228 7232 4558 2346067
Nausea 822.14 46.54 540 6920 111649 2238976
Confusional state 821.60 46.54 330 7130 24014 2326611
Drug interaction 817.20 46.54 346 7114 28817 2321808
Hyponatraemia 804.14 46.54 277 7183 13048 2337577
Drug abuse 788.20 46.54 266 7194 11760 2338865
Panic attack 750.16 46.54 199 7261 3757 2346868
Overdose 737.97 46.54 289 7171 19618 2331007
Paraesthesia 729.54 46.54 295 7165 21793 2328832
Cardiac murmur 728.74 46.54 164 7296 1487 2349138
Withdrawal syndrome 705.32 46.54 183 7277 3154 2347471
Nightmare 686.72 46.54 183 7277 3514 2347111
Disturbance in attention 678.73 46.54 199 7261 5486 2345139
Somnolence 664.80 46.54 281 7179 23204 2327421
Irritability 654.64 46.54 199 7261 6228 2344397
Anger 575.98 46.54 147 7313 2360 2348265
Headache 533.45 46.54 365 7095 79814 2270811
Depressed mood 529.28 46.54 161 7299 5037 2345588
Mood swings 523.36 46.54 144 7316 3125 2347500
Heart disease congenital 515.05 46.54 95 7365 262 2350363
Intentional overdose 510.76 46.54 190 7270 11131 2339494
Congenital anomaly 492.12 46.54 96 7364 389 2350236
Drug hypersensitivity 444.84 46.54 267 7193 46376 2304249
Tearfulness 439.96 46.54 98 7362 840 2349785
Crying 438.17 46.54 134 7326 4262 2346363
Decreased appetite 427.55 46.54 221 7239 28670 2321955
Depressed level of consciousness 418.86 46.54 148 7312 7456 2343169
Feeling abnormal 412.23 46.54 202 7258 23379 2327246
Inappropriate antidiuretic hormone secretion 403.37 46.54 109 7351 2200 2348425
Vomiting 396.57 46.54 292 7168 71310 2279315
Multiple congenital abnormalities 392.62 46.54 67 7393 95 2350530
Fatigue 380.11 46.54 305 7155 84568 2266057
Sleep disorder 375.29 46.54 131 7329 6358 2344267
Weight increased 374.39 46.54 186 7274 22151 2328474
Pulmonary valve stenosis 369.00 46.54 61 7399 61 2350564
Restlessness 366.62 46.54 118 7342 4445 2346180
Disorientation 366.05 46.54 128 7332 6244 2344381
Fall 361.36 46.54 235 7225 46864 2303761
Vertigo 335.19 46.54 133 7327 9251 2341374
Sopor 331.93 46.54 106 7354 3889 2346736
Malaise 330.63 46.54 237 7223 55348 2295277
Loss of consciousness 322.39 46.54 159 7301 18608 2332017
Mania 306.53 46.54 89 7371 2351 2348274
Abnormal behaviour 301.89 46.54 103 7357 4657 2345968
Persistent foetal circulation 299.04 46.54 50 7410 57 2350568
Memory impairment 294.14 46.54 133 7327 12790 2337835
Mydriasis 287.89 46.54 83 7377 2136 2348489
Cardio-respiratory arrest 283.14 46.54 117 7343 9029 2341596
Pulmonary artery stenosis congenital 280.43 46.54 47 7413 55 2350570
Electrocardiogram QT prolonged 276.34 46.54 110 7350 7704 2342921
Drug dependence 274.47 46.54 86 7374 2959 2347666
Coma 270.71 46.54 113 7347 8943 2341682
Delirium 269.76 46.54 97 7363 5126 2345499
Coarctation of the aorta 266.43 46.54 48 7412 110 2350515
Altered state of consciousness 266.32 46.54 89 7371 3771 2346854
Neuroleptic malignant syndrome 266.26 46.54 77 7383 2003 2348622
Hallucination 251.37 46.54 104 7356 8044 2342581
Lethargy 251.10 46.54 106 7354 8624 2342001
Parkinsonism 243.86 46.54 67 7393 1438 2349187
Dyskinesia 240.02 46.54 87 7373 4702 2345923
Seizure 239.97 46.54 143 7317 24323 2326302
Drug ineffective 238.51 46.54 255 7205 101369 2249256
Dissociation 237.59 46.54 52 7408 406 2350219
Diarrhoea 232.68 46.54 230 7230 83334 2267291
Activation syndrome 229.86 46.54 39 7421 52 2350573
Developmental delay 227.09 46.54 47 7413 271 2350354
Fallot's tetralogy 226.18 46.54 39 7421 61 2350564
Emotional disorder 223.69 46.54 68 7392 2109 2348516
Tachycardia 223.50 46.54 119 7341 16290 2334335
Pyrexia 218.32 46.54 183 7277 53525 2297100
Asthenia 216.14 46.54 172 7288 46754 2303871
Abnormal dreams 215.56 46.54 68 7392 2390 2348235
Condition aggravated 214.33 46.54 147 7313 31832 2318793
Premature baby 205.68 46.54 70 7390 3134 2347491
Apathy 204.57 46.54 57 7403 1290 2349335
Fear 203.23 46.54 66 7394 2550 2348075
Impulsive behaviour 203.05 46.54 44 7416 326 2350299
Balance disorder 201.82 46.54 94 7366 9653 2340972
Hypotension 200.74 46.54 142 7318 32294 2318331
Product complaint 199.94 46.54 75 7385 4463 2346162
Tinnitus 197.99 46.54 77 7383 5058 2345567
Agoraphobia 196.47 46.54 36 7424 94 2350531
Loss of libido 195.29 46.54 41 7419 256 2350369
Palpitations 192.66 46.54 108 7352 16348 2334277
Mood altered 192.08 46.54 64 7396 2682 2347943
Talipes 190.90 46.54 40 7420 247 2350378
Maternal drugs affecting foetus 187.91 46.54 55 7405 1492 2349133
Delusion 180.52 46.54 57 7403 2008 2348617
Hallucination, auditory 173.09 46.54 56 7404 2136 2348489
Blood creatine phosphokinase increased 170.04 46.54 69 7391 5067 2345558
Speech disorder 167.68 46.54 73 7387 6391 2344234
Amnesia 165.94 46.54 75 7385 7178 2343447
Rhabdomyolysis 165.13 46.54 73 7387 6631 2343994
Hallucination, visual 163.83 46.54 58 7402 2921 2347704
Paranoia 163.00 46.54 53 7407 2054 2348571
Bradyphrenia 160.00 46.54 45 7415 1054 2349571
Hypomania 159.30 46.54 42 7418 765 2349860
Sensory disturbance 159.15 46.54 55 7405 2577 2348048
Myoclonus 158.37 46.54 54 7406 2429 2348196
Extrapyramidal disorder 157.39 46.54 53 7407 2294 2348331
Aspartate aminotransferase increased 156.38 46.54 86 7374 12526 2338099
Cardiomegaly 156.31 46.54 53 7407 2343 2348282
Homicidal ideation 155.07 46.54 37 7423 439 2350186
Vision blurred 152.16 46.54 89 7371 14579 2336046
Depersonalisation/derealisation disorder 149.61 46.54 32 7428 221 2350404
Feeling of despair 146.80 46.54 34 7426 351 2350274
Libido decreased 145.98 46.54 36 7424 495 2350130
Tricuspid valve incompetence 145.94 46.54 46 7414 1610 2349015
Hyperreflexia 145.41 46.54 40 7420 861 2349764
Psychomotor hyperactivity 143.22 46.54 47 7413 1875 2348750
Self-injurious ideation 143.20 46.54 36 7424 538 2350087
Muscle rigidity 141.39 46.54 46 7414 1785 2348840
Bradycardia 140.33 46.54 74 7386 9907 2340718
Hyperacusis 139.52 46.54 33 7427 376 2350249
Hypoplastic left heart syndrome 138.60 46.54 24 7436 39 2350586
Panic reaction 136.60 46.54 37 7423 750 2349875
Bradykinesia 136.07 46.54 35 7425 576 2350049
Thinking abnormal 134.75 46.54 45 7415 1897 2348728
Cleft palate 134.50 46.54 29 7431 209 2350416
Logorrhoea 133.66 46.54 33 7427 456 2350169
Speech disorder developmental 133.43 46.54 26 7434 104 2350521
Dependence 133.39 46.54 32 7428 389 2350236
Nervousness 132.60 46.54 58 7402 5131 2345494
Psychotic disorder 131.70 46.54 56 7404 4623 2346002
Clonus 131.25 46.54 34 7426 576 2350049
Akathisia 129.03 46.54 42 7418 1632 2348993
Dysarthria 127.96 46.54 60 7400 6242 2344383
Psychiatric symptom 127.70 46.54 36 7424 850 2349775
Cyanosis 127.13 46.54 49 7411 3136 2347489
Hypoaesthesia 126.01 46.54 89 7371 20126 2330499
Cardiac arrest 125.03 46.54 79 7381 14851 2335774
Gait disturbance 123.99 46.54 92 7368 22453 2328172
Encephalopathy 123.13 46.54 53 7407 4508 2346117
Right ventricular hypertrophy 122.93 46.54 25 7435 130 2350495
Poisoning 121.96 46.54 46 7414 2774 2347851
Ill-defined disorder 120.83 46.54 48 7412 3330 2347295
Transposition of the great vessels 120.73 46.54 22 7438 55 2350570
Respiratory distress 117.16 46.54 53 7407 5076 2345549
Self esteem decreased 115.83 46.54 24 7436 139 2350486
Emotional distress 112.96 46.54 49 7411 4246 2346379
Cognitive disorder 111.61 46.54 52 7408 5329 2345296
Hypokalaemia 111.37 46.54 65 7395 10589 2340036
Homicide 110.44 46.54 22 7438 101 2350524
Congenital aortic stenosis 108.70 46.54 17 7443 7 2350618
Hepatic function abnormal 108.46 46.54 53 7407 6039 2344586
Treatment noncompliance 107.15 46.54 51 7409 5483 2345142
Dystonia 106.65 46.54 39 7421 2155 2348470
Visual impairment 105.45 46.54 65 7395 11690 2338935
Congenital cardiovascular anomaly 105.29 46.54 19 7441 44 2350581
Generalised tonic-clonic seizure 102.46 46.54 49 7411 5323 2345302
Respiratory arrest 101.82 46.54 51 7409 6127 2344498
Muscle spasms 100.99 46.54 80 7380 21486 2329139
Tension 100.77 46.54 27 7433 524 2350101
Obsessive-compulsive disorder 100.17 46.54 28 7432 640 2349985
Alanine aminotransferase increased 99.70 46.54 67 7393 13965 2336660
Dysmorphism 98.78 46.54 25 7435 384 2350241
Gamma-glutamyltransferase increased 97.84 46.54 48 7412 5514 2345111
Affect lability 97.13 46.54 36 7424 2066 2348559
Depressive symptom 96.49 46.54 26 7434 516 2350109
Spina bifida 96.06 46.54 20 7440 119 2350506
Failure to thrive 94.91 46.54 29 7431 913 2349712
Dehydration 94.44 46.54 78 7382 22217 2328408
Maternal exposure during pregnancy 93.87 46.54 66 7394 14797 2335828
Feeling jittery 92.63 46.54 34 7426 1898 2348727
Hypotonia 92.50 46.54 33 7427 1697 2348928
Constipation 92.30 46.54 76 7384 21553 2329072
Aortic valve incompetence 92.08 46.54 28 7432 867 2349758
Influenza like illness 91.26 46.54 60 7400 12054 2338571
Mitral valve incompetence 90.37 46.54 36 7424 2514 2348111
Pulmonary valve stenosis congenital 89.58 46.54 17 7443 57 2350568
Intentional product misuse 89.01 46.54 54 7406 9435 2341190
Poor quality sleep 88.37 46.54 33 7427 1934 2348691
Suicidal behaviour 88.10 46.54 24 7436 497 2350128
Interstitial lung disease 87.85 46.54 50 7410 7762 2342863
Flat affect 87.85 46.54 21 7439 251 2350374
Bicuspid aortic valve 87.80 46.54 16 7444 40 2350585
Mental disorder 87.07 46.54 40 7420 3967 2346658
Hypersomnia 85.93 46.54 34 7426 2332 2348293
Weight decreased 85.76 46.54 82 7378 28289 2322336
Dyspnoea 84.83 46.54 135 7325 78598 2272027
Ventricular tachycardia 84.59 46.54 36 7424 2975 2347650
Muscle twitching 84.16 46.54 35 7425 2730 2347895
Urinary retention 84.07 46.54 38 7422 3629 2346996
Drug-induced liver injury 83.75 46.54 38 7422 3661 2346964
Derealisation 82.93 46.54 19 7441 186 2350439
General physical health deterioration 82.87 46.54 60 7400 14079 2336546
Dry mouth 82.67 46.54 49 7411 8204 2342421
Unresponsive to stimuli 82.54 46.54 41 7419 4835 2345790
Cardiac failure congestive 82.45 46.54 63 7397 16038 2334587
Small for dates baby 82.23 46.54 24 7436 643 2349982
Alcoholism 82.06 46.54 21 7439 338 2350287
Lung disorder 81.47 46.54 44 7416 6168 2344457
Myalgia 81.27 46.54 73 7387 23260 2327365
Asphyxia 80.66 46.54 26 7434 978 2349647
Eating disorder 80.12 46.54 32 7428 2249 2348376
Blood lactate dehydrogenase increased 79.54 46.54 36 7424 3448 2347177
Anomalous pulmonary venous connection 78.97 46.54 14 7446 28 2350597
Compartment syndrome 78.79 46.54 21 7439 399 2350226
Hot flush 78.06 46.54 45 7415 7154 2343471
Physical assault 77.60 46.54 18 7442 187 2350438
Drug level increased 77.22 46.54 33 7427 2754 2347871
Craniosynostosis 76.38 46.54 15 7445 63 2350562
Night sweats 76.23 46.54 35 7425 3465 2347160
Death 76.06 46.54 131 7329 81337 2269288
Migraine 75.97 46.54 51 7409 10602 2340023
Respiratory depression 74.69 46.54 30 7430 2140 2348485
Alcohol abuse 74.40 46.54 19 7441 303 2350322
Sexual dysfunction 73.83 46.54 19 7441 313 2350312
Coordination abnormal 73.71 46.54 29 7431 1959 2348666
Syncope 73.44 46.54 60 7400 16815 2333810
Chills 73.42 46.54 58 7402 15494 2335131
Brain oedema 72.87 46.54 30 7430 2280 2348345
Hypertension 71.39 46.54 73 7387 27288 2323337
Hepatocellular injury 71.32 46.54 35 7425 4020 2346605
Restless legs syndrome 69.97 46.54 29 7431 2242 2348383
Musculoskeletal stiffness 69.55 46.54 51 7409 12196 2338429
Pain 69.22 46.54 108 7352 61749 2288876
Poisoning deliberate 68.55 46.54 24 7436 1167 2349458
Apnoea 68.26 46.54 25 7435 1386 2349239
Sedation 68.18 46.54 32 7428 3330 2347295
Caesarean section 68.14 46.54 34 7426 4047 2346578
Major depression 67.76 46.54 23 7437 1018 2349607
Dilatation ventricular 66.93 46.54 19 7441 460 2350165
Orthostatic hypotension 66.51 46.54 30 7430 2849 2347776
Euphoric mood 66.50 46.54 22 7438 899 2349726
Bipolar disorder 66.17 46.54 24 7436 1294 2349331
Accidental overdose 66.05 46.54 33 7427 3939 2346686
Dysstasia 65.92 46.54 30 7430 2909 2347716
Aortic stenosis 65.62 46.54 20 7440 624 2350001
Contusion 65.29 46.54 50 7410 12760 2337865
Hypoxia 65.06 46.54 38 7422 6189 2344436
Blood sodium decreased 64.39 46.54 30 7430 3070 2347555
Hyperventilation 64.03 46.54 23 7437 1206 2349419
Social avoidant behaviour 64.03 46.54 19 7441 540 2350085
Ventricular hypoplasia 64.00 46.54 12 7448 37 2350588
Abdominal pain upper 63.22 46.54 62 7398 22038 2328587
Personality change 62.07 46.54 21 7439 920 2349705
Urinary incontinence 61.19 46.54 32 7428 4201 2346424
Respiratory failure 60.74 46.54 49 7411 13479 2337146
Pruritus 60.47 46.54 84 7376 43256 2307369
Tachypnoea 60.46 46.54 26 7434 2203 2348422
Affective disorder 60.11 46.54 20 7440 832 2349793
Feelings of worthlessness 59.31 46.54 13 7447 102 2350523
Cholestasis 59.18 46.54 30 7430 3691 2346934
Abortion spontaneous 58.89 46.54 48 7412 13397 2337228
Gaze palsy 58.16 46.54 16 7444 344 2350281
White blood cell count increased 58.06 46.54 37 7423 7041 2343584
Heart rate increased 58.03 46.54 44 7416 11061 2339564
Foetal death 57.50 46.54 24 7436 1888 2348737
Delivery 57.48 46.54 14 7446 182 2350443
Bronchopulmonary dysplasia 57.26 46.54 12 7448 74 2350551
Ventricular hypertrophy 56.86 46.54 18 7442 638 2349987
Hypertonia 56.58 46.54 21 7439 1209 2349416
Liver injury 56.29 46.54 25 7435 2289 2348336
Product substitution issue 55.78 46.54 32 7428 5037 2345588
Pulmonary valve incompetence 55.74 46.54 14 7446 208 2350417
Blood chloride decreased 55.56 46.54 18 7442 688 2349937
Galactorrhoea 55.46 46.54 21 7439 1278 2349347
Movement disorder 54.53 46.54 26 7434 2802 2347823
Hepatitis 54.16 46.54 34 7426 6303 2344322
Illusion 54.15 46.54 14 7446 235 2350390
Arrhythmia 53.17 46.54 33 7427 5995 2344630
Incontinence 53.16 46.54 21 7439 1433 2349192
Abdominal pain 53.06 46.54 70 7390 34304 2316321
Epilepsy 52.97 46.54 30 7430 4609 2346016
Haematoma 52.83 46.54 31 7429 5090 2345535
Medication error 52.66 46.54 33 7427 6098 2344527
Nervous system disorder 52.13 46.54 26 7434 3090 2347535
Aspiration 52.07 46.54 21 7439 1513 2349112
Hyperbilirubinaemia neonatal 51.54 46.54 11 7449 75 2350550
Stress 51.34 46.54 34 7426 6904 2343721
Eye movement disorder 50.95 46.54 19 7441 1108 2349517
Neonatal respiratory distress syndrome 50.95 46.54 16 7444 552 2350073
Aorta hypoplasia 50.77 46.54 9 7451 18 2350607
Cerebral haemorrhage 50.76 46.54 31 7429 5473 2345152
Prescription drug used without a prescription 50.63 46.54 13 7447 212 2350413
Torsade de pointes 50.60 46.54 23 7437 2223 2348402
Cardiac disorder 49.92 46.54 35 7425 7798 2342827
C-reactive protein increased 49.57 46.54 32 7428 6223 2344402
Vesicoureteric reflux 49.49 46.54 10 7450 50 2350575
Pre-eclampsia 49.03 46.54 20 7440 1484 2349141
Pulmonary artery stenosis 49.00 46.54 10 7450 53 2350572
Liver disorder 48.84 46.54 32 7428 6382 2344243
Mental impairment 48.78 46.54 23 7437 2417 2348208
Aphasia 48.66 46.54 29 7431 4899 2345726
Bundle branch block right 48.42 46.54 17 7443 833 2349792
Decreased activity 48.15 46.54 17 7443 847 2349778
Influenza 47.92 46.54 42 7418 12936 2337689
Ventricular fibrillation 47.89 46.54 22 7438 2179 2348446
Pallor 47.64 46.54 26 7434 3716 2346909
Obsessive thoughts 46.89 46.54 12 7448 193 2350432
Muscular weakness 46.75 46.54 44 7416 14853 2335772
Dementia 46.72 46.54 23 7437 2658 2347967

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Exposure during pregnancy 3656.63 48.33 687 4197 2130 1739767
Atrial septal defect 1907.57 48.33 356 4528 1002 1740895
Foetal exposure during pregnancy 1369.86 48.33 358 4526 6001 1735896
Drug withdrawal syndrome 1346.56 48.33 330 4554 4195 1737702
Completed suicide 1289.21 48.33 421 4463 15891 1726006
Ventricular septal defect 1276.42 48.33 233 4651 545 1741352
Suicidal ideation 1072.80 48.33 315 4569 8203 1733694
Patent ductus arteriosus 1014.28 48.33 188 4696 491 1741406
Aggression 924.72 48.33 278 4606 7837 1734060
Cardiac murmur 909.88 48.33 189 4695 1033 1740864
Anxiety 898.26 48.33 318 4566 15209 1726688
Suicide attempt 675.23 48.33 214 4670 7167 1734730
Toxicity to various agents 672.21 48.33 308 4576 28833 1713064
Irritability 643.76 48.33 193 4691 5339 1736558
Tremor 627.20 48.33 234 4650 12897 1729000
Depression 618.05 48.33 247 4637 16422 1725475
Agitation 572.25 48.33 209 4675 10817 1731080
Serotonin syndrome 563.96 48.33 150 4734 2638 1739259
Heart disease congenital 556.74 48.33 103 4781 262 1741635
Congenital anomaly 540.37 48.33 103 4781 325 1741572
Talipes 503.25 48.33 97 4787 330 1741567
Insomnia 479.89 48.33 205 4679 16071 1725826
Drug abuse 458.90 48.33 189 4695 13500 1728397
Confusional state 454.94 48.33 214 4670 21064 1720833
Hyperhidrosis 451.31 48.33 182 4702 12306 1729591
Overdose 448.57 48.33 197 4687 16504 1725393
Disturbance in attention 429.05 48.33 133 4751 4101 1737796
Multiple congenital abnormalities 427.22 48.33 75 4809 123 1741774
Pulmonary valve stenosis 418.41 48.33 69 4815 57 1741840
Intentional self-injury 388.42 48.33 111 4773 2562 1739335
Intentional overdose 377.21 48.33 140 4744 7530 1734367
Dizziness 371.47 48.33 219 4665 34142 1707755
Sleep disorder 367.23 48.33 117 4767 3946 1737951
Coarctation of the aorta 342.99 48.33 60 4824 95 1741802
Paraesthesia 338.55 48.33 141 4743 10310 1731587
Mania 334.30 48.33 94 4790 2039 1739858
Anger 326.62 48.33 97 4787 2569 1739328
Pulmonary artery stenosis congenital 324.80 48.33 56 4828 77 1741820
Neuroleptic malignant syndrome 314.93 48.33 98 4786 3050 1738847
Withdrawal syndrome 314.37 48.33 91 4793 2197 1739700
Panic attack 310.23 48.33 86 4798 1766 1740131
Persistent foetal circulation 299.72 48.33 52 4832 76 1741821
Fallot's tetralogy 295.35 48.33 53 4831 105 1741792
Bicuspid aortic valve 281.40 48.33 48 4836 59 1741838
Memory impairment 278.16 48.33 108 4776 6555 1735342
Mood swings 276.65 48.33 80 4804 1922 1739975
Nightmare 267.15 48.33 84 4800 2703 1739194
Developmental delay 265.71 48.33 59 4825 455 1741442
Transposition of the great vessels 265.21 48.33 48 4836 102 1741795
Coma 262.22 48.33 106 4778 7156 1734741
Hyponatraemia 259.88 48.33 112 4772 8888 1733009
Drug interaction 257.14 48.33 161 4723 27797 1714100
Hypoplastic left heart syndrome 252.00 48.33 43 4841 53 1741844
Somnolence 251.98 48.33 133 4751 16606 1725291
Tricuspid valve incompetence 237.12 48.33 64 4820 1182 1740715
Depressed mood 236.28 48.33 78 4806 2938 1738959
Seizure 219.20 48.33 130 4754 20311 1721586
Headache 217.57 48.33 157 4727 34219 1707678
Drug withdrawal syndrome neonatal 202.40 48.33 50 4834 638 1741259
Inappropriate antidiuretic hormone secretion 198.36 48.33 60 4824 1688 1740209
Nausea 197.96 48.33 175 4709 51021 1690876
Abnormal behaviour 196.38 48.33 83 4801 6259 1735638
Impulsive behaviour 189.60 48.33 45 4839 479 1741418
Maternal drugs affecting foetus 185.10 48.33 52 4832 1119 1740778
Premature baby 182.92 48.33 64 4820 2878 1739019
Respiratory arrest 179.37 48.33 76 4808 5763 1736134
Depressed level of consciousness 173.72 48.33 77 4807 6515 1735382
Fatigue 171.52 48.33 161 4723 50620 1691277
Cardiac arrest 167.14 48.33 100 4784 15830 1726067
Blood creatine phosphokinase increased 166.84 48.33 82 4802 8774 1733123
Decreased appetite 166.84 48.33 116 4768 23755 1718142
Restlessness 165.91 48.33 66 4818 4255 1737642
Homicide 165.46 48.33 37 4847 295 1741602
Akathisia 165.44 48.33 49 4835 1279 1740618
Congenital aortic stenosis 164.33 48.33 27 4857 21 1741876
Craniosynostosis 160.64 48.33 30 4854 81 1741816
Respiratory distress 157.95 48.33 67 4817 5090 1736807
Feeling abnormal 157.24 48.33 85 4799 11081 1730816
Fall 155.41 48.33 117 4767 27097 1714800
Activation syndrome 155.34 48.33 27 4857 40 1741857
Amnesia 154.64 48.33 65 4819 4826 1737071
Condition aggravated 152.95 48.33 105 4779 21045 1720852
Vertigo 150.82 48.33 62 4822 4351 1737546
Tachycardia 150.14 48.33 86 4798 12542 1729355
Disorientation 147.65 48.33 65 4819 5404 1736493
Cardiomegaly 145.92 48.33 51 4833 2283 1739614
Lethargy 145.74 48.33 70 4814 7114 1734783
Paranoia 145.41 48.33 50 4834 2131 1739766
Delirium 144.44 48.33 67 4817 6295 1735602
Congenital cardiovascular anomaly 144.32 48.33 26 4858 53 1741844
Speech disorder developmental 143.82 48.33 31 4853 204 1741693
Hypospadias 139.91 48.33 36 4848 546 1741351
Right ventricular hypertrophy 137.47 48.33 27 4857 103 1741794
Vomiting 135.88 48.33 125 4759 38190 1703707
Cardio-respiratory arrest 134.30 48.33 72 4812 9221 1732676
Pyrexia 130.05 48.33 133 4751 46267 1695630
Malaise 129.91 48.33 109 4775 29456 1712441
Cleft lip and palate 128.03 48.33 26 4858 122 1741775
Myoclonus 127.71 48.33 46 4838 2249 1739648
Loss of consciousness 127.11 48.33 82 4802 14793 1727104
Plagiocephaly 126.98 48.33 23 4861 49 1741848
Muscle rigidity 125.65 48.33 43 4841 1805 1740092
Cyanosis 124.48 48.33 47 4837 2627 1739270
Mood altered 123.61 48.33 44 4840 2078 1739819
Cleft palate 122.96 48.33 26 4858 154 1741743
Sexual dysfunction 122.31 48.33 42 4842 1781 1740116
Aortic valve incompetence 121.22 48.33 34 4850 726 1741171
Intentional product misuse 120.49 48.33 62 4822 7296 1734601
Asthenia 118.76 48.33 111 4773 34559 1707338
Double outlet right ventricle 117.01 48.33 20 4864 25 1741872
Hallucination, auditory 116.17 48.33 42 4842 2075 1739822
Altered state of consciousness 115.62 48.33 48 4836 3449 1738448
Hyperreflexia 109.22 48.33 30 4854 591 1741306
Tearfulness 108.89 48.33 26 4858 284 1741613
Poisoning 108.85 48.33 42 4842 2490 1739407
Mitral valve incompetence 108.33 48.33 39 4845 1903 1739994
Palpitations 107.48 48.33 56 4828 6758 1735139
Pulmonary valve stenosis congenital 105.70 48.33 19 4865 38 1741859
Erectile dysfunction 104.01 48.33 48 4836 4449 1737448
Arnold-Chiari malformation 103.80 48.33 19 4865 44 1741853
Mydriasis 102.61 48.33 34 4850 1290 1740607
Hyperthermia 102.04 48.33 36 4848 1655 1740242
Tachypnoea 100.95 48.33 39 4845 2319 1739578
Hallucination 100.65 48.33 57 4827 8113 1733784
Personality change 99.75 48.33 32 4852 1094 1740803
Drug ineffective 98.75 48.33 135 4749 63666 1678231
Dyskinesia 98.55 48.33 44 4840 3775 1738122
Attention deficit/hyperactivity disorder 97.71 48.33 26 4858 452 1741445
Tinnitus 96.07 48.33 41 4843 3154 1738743
Aspartate aminotransferase increased 96.03 48.33 61 4823 10695 1731202
Psychotic disorder 95.65 48.33 47 4837 5009 1736888
Autism spectrum disorder 95.23 48.33 24 4860 333 1741564
Electrocardiogram QT prolonged 94.45 48.33 48 4836 5497 1736400
Asthma 94.01 48.33 46 4838 4858 1737039
Parkinsonism 93.61 48.33 32 4852 1337 1740560
Mental status changes 93.15 48.33 49 4835 6026 1735871
Failure to thrive 92.16 48.33 30 4854 1075 1740822
Obsessive-compulsive disorder 92.07 48.33 28 4856 800 1741097
Maternal exposure during pregnancy 91.53 48.33 27 4857 693 1741204
Aortic stenosis 91.18 48.33 26 4858 590 1741307
Cardiopulmonary failure 90.35 48.33 28 4856 853 1741044
Congenital aortic atresia 88.25 48.33 14 4870 6 1741891
Speech disorder 88.19 48.33 43 4841 4505 1737392
Weight increased 88.15 48.33 59 4825 11298 1730599
Drug dependence 87.98 48.33 39 4845 3288 1738609
Emotional disorder 87.94 48.33 29 4855 1083 1740814
Dysmorphism 87.86 48.33 23 4861 374 1741523
Rhabdomyolysis 87.00 48.33 58 4826 11032 1730865
Gait disturbance 86.94 48.33 61 4823 12609 1729288
Extrapyramidal disorder 86.64 48.33 35 4849 2342 1739555
Hypotension 86.48 48.33 87 4797 29567 1712330
Congenital aortic valve incompetence 85.58 48.33 15 4869 24 1741873
Decreased interest 84.03 48.33 22 4862 358 1741539
Balance disorder 83.80 48.33 45 4839 5767 1736130
Nervousness 81.88 48.33 33 4851 2194 1739703
Selective eating disorder 81.79 48.33 22 4862 399 1741498
Homicidal ideation 81.69 48.33 24 4860 607 1741290
Visceral congestion 81.68 48.33 17 4867 92 1741805
Apnoea 80.42 48.33 29 4855 1420 1740477
Hypomania 80.19 48.33 23 4861 533 1741364
Emotional distress 80.16 48.33 31 4853 1847 1740050
Crying 79.92 48.33 29 4855 1446 1740451
Libido decreased 79.14 48.33 28 4856 1297 1740600
Feeling of despair 78.70 48.33 19 4865 218 1741679
Pulmonary malformation 78.56 48.33 14 4870 26 1741871
Cognitive disorder 78.17 48.33 39 4845 4291 1737606
Ill-defined disorder 76.57 48.33 30 4854 1851 1740046
Hypoplastic right heart syndrome 76.47 48.33 12 4872 4 1741893
Abnormal dreams 76.41 48.33 30 4854 1861 1740036
Psychiatric symptom 75.90 48.33 24 4860 782 1741115
Hangover 75.76 48.33 18 4866 192 1741705
Mitral valve stenosis 75.59 48.33 15 4869 61 1741836
Physical assault 75.51 48.33 20 4864 341 1741556
Lung disorder 74.81 48.33 40 4844 5079 1736818
Alanine aminotransferase increased 74.79 48.33 55 4829 12223 1729674
Sopor 74.77 48.33 30 4854 1971 1739926
Pulmonary valve incompetence 74.35 48.33 17 4867 151 1741746
Gun shot wound 74.29 48.33 20 4864 364 1741533
Tonic convulsion 72.35 48.33 18 4866 236 1741661
Apathy 72.16 48.33 26 4858 1270 1740627
Thinking abnormal 71.85 48.33 26 4858 1286 1740611
Sensory disturbance 71.62 48.33 26 4858 1298 1740599
Congenital tricuspid valve atresia 71.12 48.33 12 4872 13 1741884
Cryptorchism 70.66 48.33 19 4865 344 1741553
Poor quality sleep 70.51 48.33 25 4859 1165 1740732
Epilepsy 69.52 48.33 35 4849 3924 1737973
Hamartoma 69.34 48.33 12 4872 17 1741880
Pulmonary hypertension 68.83 48.33 31 4853 2711 1739186
Product complaint 68.44 48.33 30 4854 2460 1739437
Delusion 68.28 48.33 29 4855 2202 1739695
Neonatal asphyxia 68.15 48.33 15 4869 110 1741787
Hypertension 67.81 48.33 63 4821 19385 1722512
Agitation neonatal 67.77 48.33 17 4867 231 1741666
Ventricular hypoplasia 66.75 48.33 12 4872 24 1741873
Poisoning deliberate 66.74 48.33 22 4862 820 1741077
Caesarean section 64.98 48.33 20 4864 595 1741302
Agoraphobia 64.91 48.33 13 4871 56 1741841
Fear 62.99 48.33 24 4860 1372 1740525
Tension 62.90 48.33 17 4867 314 1741583
Psychomotor hyperactivity 62.59 48.33 26 4858 1867 1740030
Respiratory failure 62.52 48.33 53 4831 14452 1727445
Death 62.38 48.33 131 4753 87312 1654585
Tremor neonatal 61.75 48.33 13 4871 75 1741822
Musculoskeletal stiffness 61.74 48.33 37 4847 5839 1736058
Eating disorder 61.67 48.33 23 4861 1239 1740658
Hallucination, visual 60.94 48.33 28 4856 2564 1739333
Self-injurious ideation 60.58 48.33 17 4867 363 1741534
Bronchopulmonary dysplasia 60.10 48.33 13 4871 87 1741810
Hypoaesthesia 59.74 48.33 44 4840 9791 1732106
Developmental hip dysplasia 59.13 48.33 12 4872 56 1741841
Unresponsive to stimuli 58.86 48.33 33 4851 4596 1737301
Mitral valve disease 58.48 48.33 15 4869 224 1741673
Flat affect 58.36 48.33 15 4869 226 1741671
Infantile apnoea 57.58 48.33 15 4869 239 1741658
Spina bifida 57.18 48.33 12 4872 68 1741829
Hyperventilation 57.10 48.33 18 4866 580 1741317
Bipolar disorder 56.76 48.33 19 4865 743 1741154
Logorrhoea 56.17 48.33 17 4867 477 1741420
Social avoidant behaviour 55.93 48.33 18 4866 621 1741276
Lactic acidosis 55.71 48.33 33 4851 5096 1736801
Ventricular hypertrophy 55.26 48.33 19 4865 807 1741090
Acute pulmonary oedema 55.19 48.33 21 4863 1196 1740701
Euphoric mood 54.84 48.33 19 4865 826 1741071
Cleft lip 54.76 48.33 12 4872 86 1741811
Blood lactate dehydrogenase increased 54.48 48.33 29 4855 3646 1738251
Congenital scoliosis 54.22 48.33 9 4875 8 1741889
Loss of libido 53.62 48.33 18 4866 710 1741187
Congenital aortic anomaly 53.53 48.33 10 4874 27 1741870
Gamma-glutamyltransferase increased 53.29 48.33 32 4852 5066 1736831
Pyloric stenosis 53.08 48.33 13 4871 159 1741738
Depersonalisation/derealisation disorder 53.08 48.33 13 4871 159 1741738
Pulmonary oedema 52.94 48.33 35 4849 6551 1735346
Congenital genitourinary abnormality 52.75 48.33 9 4875 11 1741886
Right aortic arch 52.32 48.33 9 4875 12 1741885
Cardiac failure congestive 52.29 48.33 49 4835 15221 1726676
Pulmonary artery stenosis 52.26 48.33 10 4874 32 1741865
Congenital coronary artery malformation 51.90 48.33 9 4875 13 1741884
Chills 50.95 48.33 43 4841 11644 1730253
Obsessive thoughts 50.82 48.33 13 4871 192 1741705
Somnolence neonatal 50.40 48.33 9 4875 17 1741880
Asphyxia 50.23 48.33 19 4865 1064 1740833
Dysarthria 49.82 48.33 31 4853 5228 1736669
Limb malformation 49.70 48.33 11 4873 83 1741814
Disseminated intravascular coagulation 49.33 48.33 27 4857 3587 1738310
Generalised tonic-clonic seizure 49.16 48.33 28 4856 4018 1737879
Alcohol interaction 48.86 48.33 14 4870 323 1741574
Right ventricle outflow tract obstruction 48.80 48.33 8 4876 6 1741891
Affect lability 48.72 48.33 18 4866 944 1740953
Bradycardia 48.49 48.33 40 4844 10494 1731403
Neonatal disorder 48.37 48.33 14 4870 335 1741562

Pharmacologic Action:

SourceCodeDescription
ATC N06AB05 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
FDA EPC N0000175696 Serotonin Reuptake Inhibitor
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:50949 serotonin uptake inhibitor
CHEBI has role CHEBI:35469 antidepressant
MeSH PA D000928 Antidepressive Agents
MeSH PA D018687 Antidepressive Agents, Second-Generation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D065690 Cytochrome P-450 CYP2D6 Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D017367 Serotonin Uptake Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Premenstrual dysphoric disorder indication 596004
Generalized anxiety disorder indication 21897009 DOID:14320
Social phobia indication 25501002 DOID:11257
Depressive disorder indication 35489007
Posttraumatic stress disorder indication 47505003 DOID:2055
Obsessive-compulsive disorder indication 191736004 DOID:10933
Menopausal flushing indication 198436008
Major depressive disorder indication 370143000
Panic disorder indication 371631005 DOID:594
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Fibromyalgia off-label use 203082005 DOID:631
Suicidal thoughts contraindication 6471006
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Upper gastrointestinal hemorrhage contraindication 37372002
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Hyponatremia contraindication 89627008
Seizure disorder contraindication 128613002
Mania contraindication 231494001
Disease of liver contraindication 235856003 DOID:409
Pathological fracture contraindication 268029009
Akathisia contraindication 285145004
Pregnancy, function contraindication 289908002
Serotonin syndrome contraindication 371089000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.51 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 7.5MG BASE BRISDELLE SEBELA IRELAND LTD N204516 June 28, 2013 RX CAPSULE ORAL 8946251 Aug. 4, 2026 TREATMENT OF MODERATE TO SEVERE VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE
EQ 7.5MG BASE BRISDELLE SEBELA IRELAND LTD N204516 June 28, 2013 RX CAPSULE ORAL 9393237 Aug. 4, 2026 TREATMENT OF MODERATE TO SEVERE VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE
EQ 7.5MG BASE BRISDELLE SEBELA IRELAND LTD N204516 June 28, 2013 RX CAPSULE ORAL 8658663 April 6, 2029 TREATMENT OF MODERATE TO SEVERE VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Ki 10.40 CHEMBL CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel Ki 5.07 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 7.46 DRUG MATRIX
Muscarinic acetylcholine receptor M2 GPCR Ki 6.72 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 7.42 DRUG MATRIX
Muscarinic acetylcholine receptor M4 GPCR Ki 7.47 DRUG MATRIX
Muscarinic acetylcholine receptor M5 GPCR Ki 7.05 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 6 DRUG MATRIX
Cytochrome P450 1A2 Enzyme IC50 4.96 WOMBAT-PK
Sodium-dependent dopamine transporter Transporter Kd 6.31 WOMBAT-PK
D(3) dopamine receptor GPCR Ki 5.42 WOMBAT-PK
Sodium-dependent noradrenaline transporter Transporter Kd 7.40 WOMBAT-PK
Beta-1 adrenergic receptor GPCR Ki 5 WOMBAT-PK
5-hydroxytryptamine receptor 1A GPCR Kd 4.52 CHEMBL
P2X purinoceptor 4 Ion channel IC50 5.33 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 5.65 DRUG MATRIX
Substance-P receptor GPCR IC50 6.05 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 10.30 CHEMBL
Transporter Transporter Ki 7.23 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 9.36 CHEMBL
Transporter Transporter Ki 7.48 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 5.27 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 7.01 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 5.20 CHEMBL
Quinolone resistance protein NorA Transporter IC50 5.15 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 7.70 CHEMBL

External reference:

IDSource
C3651908 UMLSCUI
D02260 KEGG_DRUG
3I3T11UD2S UNII
78246-49-8 SECONDARY_CAS_RN
4327 INN_ID
321963000 SNOMEDCT_US
4020815 VANDF
32937 RXNORM
d03157 MMSL
372595009 SNOMEDCT_US
29631 MMSL
004016 NDDF
CHEMBL490 ChEMBL_ID
DB00715 DRUGBANK_ID
CHEMBL1708 ChEMBL_ID
CHEMBL1200609 ChEMBL_ID
8PR PDB_CHEM_ID
CHEBI:7936 CHEBI
43815 PUBCHEM_CID
CHEMBL1256912 ChEMBL_ID
D017374 MESH_DESCRIPTOR_UI
CHEMBL4297919 ChEMBL_ID
4790 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Paroxetine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-2003 TABLET, FILM COATED, EXTENDED RELEASE 12.50 mg ORAL ANDA 18 sections
Paroxetine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-2004 TABLET, FILM COATED, EXTENDED RELEASE 25 mg ORAL ANDA 18 sections
Paroxetine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-2005 TABLET, FILM COATED, EXTENDED RELEASE 37.50 mg ORAL ANDA 18 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0378-7001 TABLET, FILM COATED 10 mg ORAL ANDA 14 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0378-7002 TABLET, FILM COATED 20 mg ORAL ANDA 14 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0378-7003 TABLET, FILM COATED 30 mg ORAL ANDA 14 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0378-7004 TABLET, FILM COATED 40 mg ORAL ANDA 14 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0574-0279 CAPSULE 7.50 mg ORAL NDA 19 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-5576 TABLET, FILM COATED 10 mg ORAL ANDA 13 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-5577 TABLET, FILM COATED 20 mg ORAL ANDA 13 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-5578 TABLET, FILM COATED 30 mg ORAL ANDA 13 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-5579 TABLET, FILM COATED 40 mg ORAL ANDA 13 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-7985 TABLET, FILM COATED 20 mg ORAL ANDA 15 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8173 TABLET, FILM COATED 30 mg ORAL ANDA 15 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8174 TABLET, FILM COATED 40 mg ORAL ANDA 15 sections
PAROXETINE HUMAN PRESCRIPTION DRUG LABEL 1 0904-5676 TABLET, FILM COATED 10 mg ORAL ANDA 14 sections
PAROXETINE HUMAN PRESCRIPTION DRUG LABEL 1 0904-5677 TABLET, FILM COATED 20 mg ORAL ANDA 14 sections
PAROXETINE HUMAN PRESCRIPTION DRUG LABEL 1 0904-5678 TABLET, FILM COATED 30 mg ORAL ANDA 14 sections
PAROXETINE HUMAN PRESCRIPTION DRUG LABEL 1 0904-5679 TABLET, FILM COATED 40 mg ORAL ANDA 14 sections
PAROXETINE HUMAN PRESCRIPTION DRUG LABEL 1 10544-433 TABLET, FILM COATED 20 mg ORAL ANDA 14 sections
PAROXETINE HUMAN PRESCRIPTION DRUG LABEL 1 10544-809 TABLET, FILM COATED 40 mg ORAL ANDA 14 sections
PAROXETINE HUMAN PRESCRIPTION DRUG LABEL 1 12634-248 TABLET, FILM COATED 20 mg ORAL ANDA 14 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 13107-154 TABLET, FILM COATED 10 mg ORAL ANDA 15 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 13107-155 TABLET, FILM COATED 20 mg ORAL ANDA 15 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 13107-156 TABLET, FILM COATED 30 mg ORAL ANDA 15 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 13107-157 TABLET, FILM COATED 40 mg ORAL ANDA 15 sections
PAROXETINE HUMAN PRESCRIPTION DRUG LABEL 1 16590-181 TABLET, FILM COATED 20 mg ORAL ANDA 15 sections
PAROXETINE HUMAN PRESCRIPTION DRUG LABEL 1 16590-322 TABLET, FILM COATED 10 mg ORAL ANDA 15 sections
PAXIL HUMAN PRESCRIPTION DRUG LABEL 1 16590-514 TABLET, FILM COATED, EXTENDED RELEASE 12.50 mg ORAL NDA 15 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 21695-101 TABLET, FILM COATED 10 mg ORAL ANDA 14 sections