Stem definition | Drug id | CAS RN |
---|---|---|
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives | 2068 | 61869-08-7 |
Dose | Unit | Route |
---|---|---|
20 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 5.40 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 2 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 2.53 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 18 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 18 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.06 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 13 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 29, 1992 | FDA | APOTEX TECHNOLOGIES |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug withdrawal syndrome | 939.65 | 10.27 | 585 | 108886 | 26609 | 63352942 |
Serotonin syndrome | 770.45 | 10.27 | 527 | 108944 | 28155 | 63351396 |
Atrial septal defect | 763.87 | 10.27 | 326 | 109145 | 6612 | 63372939 |
Suicidal ideation | 498.82 | 10.27 | 576 | 108895 | 61845 | 63317706 |
Ventricular septal defect | 427.35 | 10.27 | 189 | 109282 | 4189 | 63375362 |
Sopor | 396.47 | 10.27 | 319 | 109152 | 21845 | 63357706 |
Patent ductus arteriosus | 394.11 | 10.27 | 177 | 109294 | 4073 | 63375478 |
Drug abuse | 380.23 | 10.27 | 543 | 108928 | 71975 | 63307576 |
Suicide attempt | 356.55 | 10.27 | 481 | 108990 | 60437 | 63319114 |
Exposure during pregnancy | 317.82 | 10.27 | 776 | 108695 | 154771 | 63224780 |
Agitation | 292.18 | 10.27 | 433 | 109038 | 59324 | 63320227 |
Drug interaction | 287.09 | 10.27 | 958 | 108513 | 228173 | 63151378 |
Anxiety | 277.38 | 10.27 | 915 | 108556 | 216626 | 63162925 |
Alopecia | 276.68 | 10.27 | 118 | 109353 | 337418 | 63042133 |
Contraindicated product administered | 272.58 | 10.27 | 29 | 109442 | 217619 | 63161932 |
Systemic lupus erythematosus | 263.78 | 10.27 | 27 | 109444 | 208891 | 63170660 |
Tremor | 261.86 | 10.27 | 652 | 108819 | 131587 | 63247964 |
Heart disease congenital | 248.38 | 10.27 | 91 | 109380 | 1208 | 63378343 |
Congenital anomaly | 241.29 | 10.27 | 97 | 109374 | 1679 | 63377872 |
Glossodynia | 239.67 | 10.27 | 18 | 109453 | 178858 | 63200693 |
Mydriasis | 226.45 | 10.27 | 178 | 109293 | 11778 | 63367773 |
Intentional self-injury | 223.70 | 10.27 | 248 | 109223 | 25439 | 63354112 |
Foetal exposure during pregnancy | 222.38 | 10.27 | 275 | 109196 | 31687 | 63347864 |
Nightmare | 216.83 | 10.27 | 213 | 109258 | 18981 | 63360570 |
Pulmonary valve stenosis | 215.24 | 10.27 | 60 | 109411 | 298 | 63379253 |
Off label use | 209.70 | 10.27 | 541 | 108930 | 673921 | 62705630 |
Multiple congenital abnormalities | 203.18 | 10.27 | 64 | 109407 | 516 | 63379035 |
Drug ineffective | 201.81 | 10.27 | 1024 | 108447 | 1043741 | 62335810 |
Cardiac murmur | 199.88 | 10.27 | 180 | 109291 | 14372 | 63365179 |
Drug intolerance | 190.39 | 10.27 | 152 | 109319 | 308509 | 63071042 |
Hallucinations, mixed | 187.47 | 10.27 | 112 | 109359 | 4717 | 63374834 |
Abdominal discomfort | 184.53 | 10.27 | 169 | 109302 | 320716 | 63058835 |
Pericarditis | 182.80 | 10.27 | 11 | 109460 | 131568 | 63247983 |
Hyponatraemia | 182.06 | 10.27 | 513 | 108958 | 111387 | 63268164 |
Somnolence | 179.16 | 10.27 | 695 | 108776 | 177990 | 63201561 |
Joint swelling | 174.10 | 10.27 | 185 | 109286 | 327481 | 63052070 |
Persistent foetal circulation | 173.47 | 10.27 | 46 | 109425 | 182 | 63379369 |
Depersonalisation/derealisation disorder | 172.90 | 10.27 | 71 | 109400 | 1301 | 63378250 |
Irritability | 169.94 | 10.27 | 240 | 109231 | 31454 | 63348097 |
Synovitis | 166.87 | 10.27 | 57 | 109414 | 186861 | 63192690 |
Neuroleptic malignant syndrome | 163.36 | 10.27 | 148 | 109323 | 11908 | 63367643 |
Anger | 163.10 | 10.27 | 150 | 109321 | 12306 | 63367245 |
Mania | 162.07 | 10.27 | 149 | 109322 | 12218 | 63367333 |
Swelling | 159.51 | 10.27 | 144 | 109327 | 275234 | 63104317 |
Pulmonary artery stenosis congenital | 154.85 | 10.27 | 43 | 109428 | 210 | 63379341 |
Disorientation | 152.79 | 10.27 | 257 | 109214 | 39195 | 63340356 |
Bradyphrenia | 147.69 | 10.27 | 111 | 109360 | 6869 | 63372682 |
Rash | 145.68 | 10.27 | 489 | 108982 | 560382 | 62819169 |
Treatment failure | 144.12 | 10.27 | 82 | 109389 | 198961 | 63180590 |
Myoglobin urine present | 143.61 | 10.27 | 53 | 109418 | 719 | 63378832 |
Dissociation | 140.83 | 10.27 | 78 | 109393 | 2841 | 63376710 |
Rheumatoid arthritis | 140.79 | 10.27 | 138 | 109333 | 253681 | 63125870 |
Derealisation | 140.38 | 10.27 | 59 | 109412 | 1149 | 63378402 |
Infusion related reaction | 140.25 | 10.27 | 130 | 109341 | 245391 | 63134160 |
Hallucination, auditory | 136.87 | 10.27 | 138 | 109333 | 12686 | 63366865 |
Panic attack | 136.19 | 10.27 | 180 | 109291 | 22151 | 63357400 |
Coarctation of the aorta | 135.04 | 10.27 | 47 | 109424 | 532 | 63379019 |
Helicobacter infection | 134.39 | 10.27 | 6 | 109465 | 92779 | 63286772 |
Completed suicide | 132.66 | 10.27 | 550 | 108921 | 145123 | 63234428 |
Activation syndrome | 132.52 | 10.27 | 37 | 109434 | 185 | 63379366 |
Hyperhidrosis | 131.34 | 10.27 | 447 | 109024 | 107389 | 63272162 |
Disturbance in attention | 131.23 | 10.27 | 236 | 109235 | 37953 | 63341598 |
Mood swings | 130.13 | 10.27 | 159 | 109312 | 18089 | 63361462 |
Overdose | 129.76 | 10.27 | 465 | 109006 | 114613 | 63264938 |
Arthropathy | 128.65 | 10.27 | 129 | 109342 | 234663 | 63144888 |
Aggression | 127.54 | 10.27 | 179 | 109292 | 23319 | 63356232 |
Depression | 127.53 | 10.27 | 672 | 108799 | 195820 | 63183731 |
Discomfort | 125.45 | 10.27 | 66 | 109405 | 167308 | 63212243 |
Feeling of despair | 125.33 | 10.27 | 67 | 109404 | 2272 | 63377279 |
Restlessness | 123.66 | 10.27 | 199 | 109272 | 29254 | 63350297 |
Confusional state | 123.58 | 10.27 | 763 | 108708 | 235617 | 63143934 |
Product use issue | 121.00 | 10.27 | 121 | 109350 | 220399 | 63159152 |
Hypersensitivity | 119.97 | 10.27 | 200 | 109271 | 292485 | 63087066 |
Inappropriate antidiuretic hormone secretion | 117.25 | 10.27 | 139 | 109332 | 15323 | 63364228 |
Withdrawal syndrome | 112.52 | 10.27 | 155 | 109316 | 19842 | 63359709 |
Fallot's tetralogy | 112.16 | 10.27 | 27 | 109444 | 64 | 63379487 |
Pain | 111.65 | 10.27 | 784 | 108687 | 739844 | 62639707 |
Gastric pH decreased | 107.66 | 10.27 | 43 | 109428 | 731 | 63378820 |
Dyskinesia | 105.18 | 10.27 | 194 | 109277 | 31808 | 63347743 |
Developmental delay | 101.23 | 10.27 | 50 | 109421 | 1433 | 63378118 |
Toxicity to various agents | 101.03 | 10.27 | 751 | 108720 | 246499 | 63133052 |
Blister | 99.03 | 10.27 | 50 | 109421 | 129764 | 63249787 |
Hepatic enzyme increased | 97.87 | 10.27 | 123 | 109348 | 202205 | 63177346 |
Insomnia | 96.72 | 10.27 | 669 | 108802 | 214583 | 63164968 |
Therapeutic product effect decreased | 96.02 | 10.27 | 115 | 109356 | 193072 | 63186479 |
Stomatitis | 93.63 | 10.27 | 62 | 109409 | 138663 | 63240888 |
Wound | 91.35 | 10.27 | 88 | 109383 | 163175 | 63216376 |
Poisoning deliberate | 90.31 | 10.27 | 104 | 109367 | 11114 | 63368437 |
Extrapyramidal disorder | 90.29 | 10.27 | 113 | 109358 | 13171 | 63366380 |
Folliculitis | 88.90 | 10.27 | 9 | 109462 | 70308 | 63309243 |
Peripheral swelling | 87.20 | 10.27 | 207 | 109264 | 265735 | 63113816 |
Nasopharyngitis | 86.51 | 10.27 | 194 | 109277 | 254063 | 63125488 |
Drug dependence | 86.28 | 10.27 | 153 | 109318 | 24330 | 63355221 |
Tearfulness | 85.75 | 10.27 | 65 | 109406 | 4074 | 63375477 |
Cogwheel rigidity | 85.19 | 10.27 | 49 | 109422 | 1921 | 63377630 |
Intentional product use issue | 85.18 | 10.27 | 58 | 109413 | 127834 | 63251717 |
Flat affect | 84.69 | 10.27 | 44 | 109427 | 1406 | 63378145 |
Agoraphobia | 84.17 | 10.27 | 30 | 109441 | 366 | 63379185 |
Arthralgia | 83.28 | 10.27 | 608 | 108863 | 569102 | 62810449 |
Muscle rigidity | 81.66 | 10.27 | 100 | 109371 | 11400 | 63368151 |
Muscle injury | 80.98 | 10.27 | 9 | 109462 | 65336 | 63314215 |
Transposition of the great vessels | 77.84 | 10.27 | 25 | 109446 | 216 | 63379335 |
Crying | 77.32 | 10.27 | 142 | 109329 | 23201 | 63356350 |
Homicidal ideation | 76.89 | 10.27 | 44 | 109427 | 1708 | 63377843 |
Congenital aortic stenosis | 76.28 | 10.27 | 17 | 109454 | 24 | 63379527 |
Emotional disorder | 74.21 | 10.27 | 103 | 109368 | 13276 | 63366275 |
Talipes | 73.88 | 10.27 | 41 | 109430 | 1499 | 63378052 |
Bronchial neoplasm | 73.82 | 10.27 | 29 | 109442 | 471 | 63379080 |
Febrile neutropenia | 73.32 | 10.27 | 58 | 109413 | 118391 | 63261160 |
Lower respiratory tract infection | 72.06 | 10.27 | 73 | 109398 | 132234 | 63247317 |
Memory impairment | 72.02 | 10.27 | 363 | 109108 | 103895 | 63275656 |
H1N1 influenza | 71.87 | 10.27 | 42 | 109429 | 1697 | 63377854 |
Abnormal behaviour | 71.80 | 10.27 | 131 | 109340 | 21295 | 63358256 |
Dystonia | 71.64 | 10.27 | 103 | 109368 | 13716 | 63365835 |
Hyperreflexia | 71.04 | 10.27 | 68 | 109403 | 5866 | 63373685 |
Depressed mood | 71.00 | 10.27 | 190 | 109281 | 40001 | 63339550 |
Delirium | 70.96 | 10.27 | 220 | 109251 | 50321 | 63329230 |
Impulsive behaviour | 70.13 | 10.27 | 40 | 109431 | 1543 | 63378008 |
Thermal burn | 69.96 | 10.27 | 68 | 109403 | 5978 | 63373573 |
Hypoplastic left heart syndrome | 69.88 | 10.27 | 22 | 109449 | 177 | 63379374 |
Bronchial haemorrhage | 69.08 | 10.27 | 29 | 109442 | 563 | 63378988 |
Nervousness | 69.00 | 10.27 | 160 | 109311 | 30819 | 63348732 |
Maternal exposure during pregnancy | 68.43 | 10.27 | 176 | 109295 | 219886 | 63159665 |
Mobility decreased | 68.12 | 10.27 | 65 | 109406 | 121094 | 63258457 |
Intentional overdose | 67.45 | 10.27 | 280 | 109191 | 73872 | 63305679 |
Psoriatic arthropathy | 67.20 | 10.27 | 37 | 109434 | 91483 | 63288068 |
Parkinsonism | 66.53 | 10.27 | 86 | 109385 | 10353 | 63369198 |
Blood creatine phosphokinase increased | 66.50 | 10.27 | 156 | 109315 | 30274 | 63349277 |
Altered state of consciousness | 66.01 | 10.27 | 139 | 109332 | 25091 | 63354460 |
Speech disorder developmental | 65.21 | 10.27 | 29 | 109442 | 651 | 63378900 |
Nasal turbinate hypertrophy | 65.13 | 10.27 | 30 | 109441 | 733 | 63378818 |
Breath sounds abnormal | 64.68 | 10.27 | 87 | 109384 | 10886 | 63368665 |
Cough | 62.39 | 10.27 | 276 | 109195 | 292467 | 63087084 |
Libido increased | 62.32 | 10.27 | 35 | 109436 | 1310 | 63378241 |
Congenital cardiovascular anomaly | 61.73 | 10.27 | 18 | 109453 | 108 | 63379443 |
Cyanosis | 61.18 | 10.27 | 107 | 109364 | 16828 | 63362723 |
General physical health deterioration | 61.14 | 10.27 | 163 | 109308 | 201239 | 63178312 |
Myoclonus | 60.93 | 10.27 | 103 | 109368 | 15765 | 63363786 |
Psychotic disorder | 60.82 | 10.27 | 136 | 109335 | 25576 | 63353975 |
Rheumatoid factor positive | 60.72 | 10.27 | 35 | 109436 | 84371 | 63295180 |
Apathy | 60.08 | 10.27 | 75 | 109396 | 8719 | 63370832 |
Amylase increased | 60.00 | 10.27 | 64 | 109407 | 6281 | 63373270 |
Infection | 59.14 | 10.27 | 200 | 109271 | 228973 | 63150578 |
Clonus | 59.08 | 10.27 | 55 | 109416 | 4581 | 63374970 |
Delusion | 58.57 | 10.27 | 87 | 109384 | 11930 | 63367621 |
Endometrial ablation | 58.46 | 10.27 | 30 | 109441 | 934 | 63378617 |
Bicuspid aortic valve | 58.02 | 10.27 | 17 | 109454 | 104 | 63379447 |
Cleft palate | 57.08 | 10.27 | 30 | 109441 | 982 | 63378569 |
Feeling of body temperature change | 56.52 | 10.27 | 55 | 109416 | 4842 | 63374709 |
Affective disorder | 56.38 | 10.27 | 61 | 109410 | 6085 | 63373466 |
Homicide | 55.68 | 10.27 | 22 | 109449 | 363 | 63379188 |
Drooling | 55.40 | 10.27 | 49 | 109422 | 3819 | 63375732 |
Pulmonary valve stenosis congenital | 55.20 | 10.27 | 18 | 109453 | 164 | 63379387 |
Renal ischaemia | 54.38 | 10.27 | 25 | 109446 | 608 | 63378943 |
Impaired healing | 54.23 | 10.27 | 58 | 109413 | 102484 | 63277067 |
Irritable bowel syndrome | 54.03 | 10.27 | 38 | 109433 | 82374 | 63297177 |
Abnormal dreams | 53.95 | 10.27 | 78 | 109393 | 10438 | 63369113 |
Anomalous pulmonary venous connection | 53.70 | 10.27 | 14 | 109457 | 51 | 63379500 |
Hyperprolactinaemia | 53.07 | 10.27 | 48 | 109423 | 3852 | 63375699 |
Toxic encephalopathy | 52.97 | 10.27 | 61 | 109410 | 6518 | 63373033 |
Right ventricular hypertrophy | 51.88 | 10.27 | 25 | 109446 | 678 | 63378873 |
Hallucination | 51.43 | 10.27 | 209 | 109262 | 54608 | 63324943 |
Hallucination, visual | 51.28 | 10.27 | 107 | 109364 | 19191 | 63360360 |
Malignant neoplasm progression | 51.08 | 10.27 | 40 | 109431 | 82081 | 63297470 |
Therapeutic product ineffective | 50.98 | 10.27 | 34 | 109437 | 1738 | 63377813 |
Feeling jittery | 50.14 | 10.27 | 86 | 109385 | 13317 | 63366234 |
Knee arthroplasty | 49.25 | 10.27 | 16 | 109455 | 54190 | 63325361 |
Hip arthroplasty | 49.06 | 10.27 | 11 | 109460 | 47635 | 63331916 |
Fatigue | 48.39 | 10.27 | 1165 | 108306 | 886863 | 62492688 |
Speech disorder | 48.17 | 10.27 | 167 | 109304 | 40462 | 63339089 |
Depressed level of consciousness | 47.78 | 10.27 | 223 | 109248 | 61855 | 63317696 |
Bronchial disorder | 47.70 | 10.27 | 29 | 109442 | 1261 | 63378290 |
Vertigo | 47.47 | 10.27 | 217 | 109254 | 59670 | 63319881 |
Menstrual disorder | 47.46 | 10.27 | 52 | 109419 | 5261 | 63374290 |
COVID-19 | 46.53 | 10.27 | 77 | 109394 | 113026 | 63266525 |
PCO2 increased | 46.19 | 10.27 | 28 | 109443 | 1211 | 63378340 |
Death | 46.11 | 10.27 | 418 | 109053 | 373963 | 63005588 |
Troponin increased | 46.10 | 10.27 | 71 | 109400 | 10050 | 63369501 |
Pneumonia | 45.99 | 10.27 | 535 | 108936 | 456232 | 62923319 |
Galactorrhoea | 44.86 | 10.27 | 45 | 109426 | 4110 | 63375441 |
Emotional distress | 44.13 | 10.27 | 140 | 109331 | 32409 | 63347142 |
Loss of libido | 43.99 | 10.27 | 28 | 109443 | 1321 | 63378230 |
Self esteem decreased | 43.89 | 10.27 | 22 | 109449 | 651 | 63378900 |
Dependence | 43.87 | 10.27 | 33 | 109438 | 2044 | 63377507 |
Craniosynostosis | 43.73 | 10.27 | 15 | 109456 | 162 | 63379389 |
Social anxiety disorder | 43.33 | 10.27 | 19 | 109452 | 412 | 63379139 |
Muscle disorder | 43.29 | 10.27 | 48 | 109423 | 4921 | 63374630 |
Hypomania | 43.26 | 10.27 | 54 | 109417 | 6276 | 63373275 |
Akathisia | 42.84 | 10.27 | 65 | 109406 | 9081 | 63370470 |
Logorrhoea | 42.49 | 10.27 | 35 | 109436 | 2475 | 63377076 |
Accidental poisoning | 42.35 | 10.27 | 21 | 109450 | 607 | 63378944 |
Gastrointestinal disorder | 42.29 | 10.27 | 103 | 109368 | 131136 | 63248415 |
Seizure | 42.27 | 10.27 | 381 | 109090 | 132253 | 63247298 |
Obsessive-compulsive disorder | 42.06 | 10.27 | 43 | 109428 | 4017 | 63375534 |
Depressive symptom | 41.69 | 10.27 | 43 | 109428 | 4059 | 63375492 |
Dyspnoea | 41.54 | 10.27 | 848 | 108623 | 660465 | 62719086 |
Fear | 41.40 | 10.27 | 87 | 109384 | 15679 | 63363872 |
Paranoia | 41.17 | 10.27 | 73 | 109398 | 11606 | 63367945 |
Encephalopathy | 40.90 | 10.27 | 153 | 109318 | 38467 | 63341084 |
Electrocardiogram QT prolonged | 40.89 | 10.27 | 207 | 109264 | 59323 | 63320228 |
Disease progression | 40.62 | 10.27 | 95 | 109376 | 122663 | 63256888 |
Hostility | 40.11 | 10.27 | 30 | 109441 | 1842 | 63377709 |
Incontinence | 40.09 | 10.27 | 72 | 109399 | 11560 | 63367991 |
Rhonchi | 39.65 | 10.27 | 34 | 109437 | 2542 | 63377009 |
Hyperacusis | 39.02 | 10.27 | 31 | 109440 | 2082 | 63377469 |
Spina bifida | 38.84 | 10.27 | 22 | 109449 | 837 | 63378714 |
Fibromyalgia | 38.73 | 10.27 | 49 | 109422 | 80371 | 63299180 |
Restless legs syndrome | 38.33 | 10.27 | 93 | 109378 | 18438 | 63361113 |
Fall | 38.09 | 10.27 | 915 | 108556 | 391419 | 62988132 |
Amnesia | 37.98 | 10.27 | 193 | 109278 | 55392 | 63324159 |
Hypoaesthesia oral | 37.88 | 10.27 | 75 | 109396 | 12958 | 63366593 |
Parosmia | 37.79 | 10.27 | 50 | 109421 | 6156 | 63373395 |
Substance abuse | 37.75 | 10.27 | 44 | 109427 | 4763 | 63374788 |
Congenital mitral valve stenosis | 37.55 | 10.27 | 7 | 109464 | 0 | 63379551 |
Paraesthesia | 37.10 | 10.27 | 424 | 109047 | 156542 | 63223009 |
Diabetes insipidus | 37.09 | 10.27 | 33 | 109438 | 2592 | 63376959 |
Chorea | 36.99 | 10.27 | 27 | 109444 | 1597 | 63377954 |
Sinusitis | 36.90 | 10.27 | 234 | 109237 | 226419 | 63153132 |
Libido decreased | 36.58 | 10.27 | 33 | 109438 | 2639 | 63376912 |
Loss of consciousness | 36.46 | 10.27 | 337 | 109134 | 117784 | 63261767 |
Product complaint | 36.37 | 10.27 | 73 | 109398 | 12736 | 63366815 |
Tinnitus | 35.96 | 10.27 | 139 | 109332 | 35489 | 63344062 |
Muscle twitching | 35.76 | 10.27 | 94 | 109377 | 19574 | 63359977 |
PO2 increased | 35.72 | 10.27 | 21 | 109450 | 858 | 63378693 |
Blood lactate dehydrogenase increased | 35.62 | 10.27 | 104 | 109367 | 23012 | 63356539 |
Psychomotor hyperactivity | 35.48 | 10.27 | 65 | 109406 | 10598 | 63368953 |
Treatment noncompliance | 34.76 | 10.27 | 142 | 109329 | 37183 | 63342368 |
Urinary retention | 34.58 | 10.27 | 123 | 109348 | 30178 | 63349373 |
Dizziness | 34.57 | 10.27 | 978 | 108493 | 428947 | 62950604 |
Ventricular hypoplasia | 34.00 | 10.27 | 12 | 109459 | 142 | 63379409 |
Therapy non-responder | 33.77 | 10.27 | 49 | 109422 | 75852 | 63303699 |
Hepatocellular injury | 33.73 | 10.27 | 114 | 109357 | 27267 | 63352284 |
Tachycardia | 33.45 | 10.27 | 331 | 109140 | 117825 | 63261726 |
Generalised anxiety disorder | 33.20 | 10.27 | 28 | 109443 | 2046 | 63377505 |
Maternal drugs affecting foetus | 33.11 | 10.27 | 43 | 109428 | 5199 | 63374352 |
Respiratory depression | 32.94 | 10.27 | 73 | 109398 | 13642 | 63365909 |
Product dose omission issue | 32.70 | 10.27 | 253 | 109218 | 234060 | 63145491 |
Endocrine ophthalmopathy | 32.56 | 10.27 | 18 | 109453 | 653 | 63378898 |
Paralysis | 32.50 | 10.27 | 60 | 109411 | 9840 | 63369711 |
Prescription form tampering | 32.22 | 10.27 | 17 | 109454 | 561 | 63378990 |
DiGeorge's syndrome | 32.19 | 10.27 | 6 | 109465 | 0 | 63379551 |
Congenital aortic valve incompetence | 32.19 | 10.27 | 6 | 109465 | 0 | 63379551 |
Balance disorder | 31.92 | 10.27 | 252 | 109219 | 84170 | 63295381 |
Bradykinesia | 31.91 | 10.27 | 42 | 109429 | 5146 | 63374405 |
Blood pH decreased | 31.64 | 10.27 | 30 | 109441 | 2557 | 63376994 |
Weight increased | 31.58 | 10.27 | 628 | 108843 | 260164 | 63119387 |
Neonatal behavioural syndrome | 31.30 | 10.27 | 9 | 109462 | 51 | 63379500 |
Electroencephalogram abnormal | 31.18 | 10.27 | 35 | 109436 | 3637 | 63375914 |
Increased appetite | 31.16 | 10.27 | 58 | 109413 | 9572 | 63369979 |
Macular degeneration | 31.12 | 10.27 | 3 | 109468 | 24373 | 63355178 |
Self-injurious ideation | 30.94 | 10.27 | 30 | 109441 | 2629 | 63376922 |
Neutrophil count decreased | 30.83 | 10.27 | 31 | 109440 | 56375 | 63323176 |
Neuropathy peripheral | 30.81 | 10.27 | 97 | 109374 | 113570 | 63265981 |
Myelosuppression | 30.04 | 10.27 | 3 | 109468 | 23700 | 63355851 |
Soft tissue injury | 30.00 | 10.27 | 24 | 109447 | 1628 | 63377923 |
Injection site pain | 29.69 | 10.27 | 119 | 109352 | 129681 | 63249870 |
Ebstein's anomaly | 29.56 | 10.27 | 7 | 109464 | 15 | 63379536 |
Coma | 29.40 | 10.27 | 201 | 109270 | 64163 | 63315388 |
Asphyxia | 29.05 | 10.27 | 44 | 109427 | 6137 | 63373414 |
Toxic shock syndrome | 28.77 | 10.27 | 18 | 109453 | 824 | 63378727 |
Joint range of motion decreased | 28.71 | 10.27 | 10 | 109461 | 32418 | 63347133 |
Schizophrenia | 28.60 | 10.27 | 57 | 109414 | 9895 | 63369656 |
Pain in extremity | 28.58 | 10.27 | 401 | 109070 | 331085 | 63048466 |
Coma scale | 28.33 | 10.27 | 8 | 109463 | 42 | 63379509 |
Blood sodium decreased | 28.15 | 10.27 | 99 | 109372 | 24153 | 63355398 |
Alcoholism | 27.99 | 10.27 | 24 | 109447 | 1794 | 63377757 |
Apraxia | 27.96 | 10.27 | 24 | 109447 | 1797 | 63377754 |
Feelings of worthlessness | 27.73 | 10.27 | 13 | 109458 | 331 | 63379220 |
Hypertonia | 27.69 | 10.27 | 37 | 109434 | 4600 | 63374951 |
Rhabdomyolysis | 27.54 | 10.27 | 149 | 109322 | 43802 | 63335749 |
Sinus tachycardia | 27.26 | 10.27 | 98 | 109373 | 24170 | 63355381 |
Cardio-respiratory arrest | 27.24 | 10.27 | 187 | 109284 | 59772 | 63319779 |
Cerebral microhaemorrhage | 27.21 | 10.27 | 10 | 109461 | 134 | 63379417 |
Hepatotoxicity | 27.15 | 10.27 | 15 | 109456 | 37026 | 63342525 |
Injection site erythema | 27.00 | 10.27 | 65 | 109406 | 83109 | 63296442 |
Joint hyperextension | 26.93 | 10.27 | 13 | 109458 | 354 | 63379197 |
Cardiomegaly | 26.90 | 10.27 | 79 | 109392 | 17535 | 63362016 |
Sensory disturbance | 26.57 | 10.27 | 67 | 109404 | 13605 | 63365946 |
Micrognathia | 26.56 | 10.27 | 12 | 109459 | 280 | 63379271 |
Vesicoureteric reflux | 26.23 | 10.27 | 11 | 109460 | 213 | 63379338 |
Mental disorder | 26.06 | 10.27 | 101 | 109370 | 25818 | 63353733 |
Neutropenia | 25.82 | 10.27 | 186 | 109285 | 174819 | 63204732 |
Eye movement disorder | 25.69 | 10.27 | 38 | 109433 | 5190 | 63374361 |
Pyrexia | 25.54 | 10.27 | 617 | 108854 | 469861 | 62909690 |
Adverse drug reaction | 25.33 | 10.27 | 63 | 109408 | 79651 | 63299900 |
Post-traumatic neck syndrome | 25.27 | 10.27 | 24 | 109447 | 2050 | 63377501 |
Soliloquy | 25.19 | 10.27 | 11 | 109460 | 236 | 63379315 |
Dysmorphism | 25.03 | 10.27 | 25 | 109446 | 2271 | 63377280 |
Creutzfeldt-Jakob disease | 24.88 | 10.27 | 10 | 109461 | 173 | 63379378 |
Vision blurred | 24.80 | 10.27 | 255 | 109216 | 91669 | 63287882 |
Negative thoughts | 24.79 | 10.27 | 17 | 109454 | 910 | 63378641 |
Sepsis | 24.44 | 10.27 | 159 | 109312 | 152964 | 63226587 |
Congenital heart valve disorder | 24.33 | 10.27 | 8 | 109463 | 75 | 63379476 |
Personality disorder | 24.03 | 10.27 | 39 | 109432 | 5772 | 63373779 |
Obsessive thoughts | 23.70 | 10.27 | 14 | 109457 | 577 | 63378974 |
Anaphylactic reaction | 23.63 | 10.27 | 49 | 109422 | 66051 | 63313500 |
Anorgasmia | 23.44 | 10.27 | 14 | 109457 | 589 | 63378962 |
Cytomegalovirus infection | 23.33 | 10.27 | 4 | 109467 | 20948 | 63358603 |
Compartment syndrome | 23.32 | 10.27 | 24 | 109447 | 2260 | 63377291 |
Aorta hypoplasia | 23.26 | 10.27 | 9 | 109462 | 140 | 63379411 |
Aortic valve incompetence | 23.16 | 10.27 | 39 | 109432 | 5949 | 63373602 |
Disinhibition | 23.16 | 10.27 | 16 | 109455 | 867 | 63378684 |
Vulvovaginal burning sensation | 23.06 | 10.27 | 23 | 109448 | 2086 | 63377465 |
Panic reaction | 22.95 | 10.27 | 32 | 109439 | 4142 | 63375409 |
Psychiatric symptom | 22.89 | 10.27 | 36 | 109435 | 5187 | 63374364 |
Tricuspid valve incompetence | 22.74 | 10.27 | 66 | 109405 | 14555 | 63364996 |
Alcohol abuse | 22.73 | 10.27 | 23 | 109448 | 2123 | 63377428 |
Oedema | 22.64 | 10.27 | 89 | 109382 | 97533 | 63282018 |
Rhinalgia | 22.39 | 10.27 | 20 | 109451 | 1579 | 63377972 |
Liver injury | 22.37 | 10.27 | 44 | 109427 | 60476 | 63319075 |
Oxygen saturation abnormal | 22.37 | 10.27 | 29 | 109442 | 3500 | 63376051 |
Mucosal inflammation | 22.17 | 10.27 | 29 | 109442 | 46899 | 63332652 |
Bronchopulmonary dysplasia | 22.07 | 10.27 | 12 | 109459 | 421 | 63379130 |
Dilatation ventricular | 21.96 | 10.27 | 24 | 109447 | 2421 | 63377130 |
Hypoplastic right heart syndrome | 21.95 | 10.27 | 7 | 109464 | 59 | 63379492 |
Urticaria thermal | 21.92 | 10.27 | 12 | 109459 | 427 | 63379124 |
Eyelid disorder | 21.78 | 10.27 | 21 | 109450 | 1828 | 63377723 |
Blood bicarbonate decreased | 21.57 | 10.27 | 26 | 109445 | 2915 | 63376636 |
Altered visual depth perception | 21.57 | 10.27 | 11 | 109460 | 338 | 63379213 |
Tension | 21.56 | 10.27 | 27 | 109444 | 3148 | 63376403 |
Middle insomnia | 21.55 | 10.27 | 59 | 109412 | 12584 | 63366967 |
Pilonidal cyst congenital | 21.46 | 10.27 | 4 | 109467 | 0 | 63379551 |
Congenital aortic atresia | 21.46 | 10.27 | 4 | 109467 | 0 | 63379551 |
Mood altered | 21.45 | 10.27 | 65 | 109406 | 14678 | 63364873 |
Musculoskeletal stiffness | 21.45 | 10.27 | 209 | 109262 | 184409 | 63195142 |
Somnolence neonatal | 21.45 | 10.27 | 8 | 109463 | 112 | 63379439 |
Metastases to liver | 21.43 | 10.27 | 7 | 109464 | 23632 | 63355919 |
Ventricular hypertrophy | 21.41 | 10.27 | 28 | 109443 | 3408 | 63376143 |
Phonophobia | 21.02 | 10.27 | 11 | 109460 | 357 | 63379194 |
Blood triglycerides increased | 21.01 | 10.27 | 58 | 109413 | 12430 | 63367121 |
Upper respiratory tract infection | 20.86 | 10.27 | 72 | 109399 | 81975 | 63297576 |
Musculoskeletal pain | 20.84 | 10.27 | 85 | 109386 | 92192 | 63287359 |
Hypokinesia | 20.80 | 10.27 | 62 | 109409 | 13874 | 63365677 |
Sensory loss | 20.77 | 10.27 | 51 | 109420 | 10187 | 63369364 |
Wolff-Parkinson-White syndrome | 20.76 | 10.27 | 8 | 109463 | 123 | 63379428 |
Pulmonary artery stenosis | 20.75 | 10.27 | 9 | 109462 | 190 | 63379361 |
Chemical submission | 20.72 | 10.27 | 10 | 109461 | 272 | 63379279 |
Clinodactyly | 20.65 | 10.27 | 8 | 109463 | 125 | 63379426 |
Hot flush | 20.60 | 10.27 | 155 | 109316 | 51004 | 63328547 |
Poisoning | 20.50 | 10.27 | 61 | 109410 | 13639 | 63365912 |
Euphoric mood | 20.48 | 10.27 | 33 | 109438 | 4854 | 63374697 |
Condition aggravated | 20.32 | 10.27 | 533 | 108938 | 401684 | 62977867 |
Poor quality sleep | 20.30 | 10.27 | 78 | 109393 | 19857 | 63359694 |
Physical assault | 20.24 | 10.27 | 15 | 109456 | 908 | 63378643 |
Aphasia | 20.09 | 10.27 | 111 | 109360 | 32889 | 63346662 |
Sternal fracture | 20.03 | 10.27 | 22 | 109449 | 2232 | 63377319 |
Posterior reversible encephalopathy syndrome | 20.01 | 10.27 | 3 | 109468 | 17342 | 63362209 |
Sluggishness | 19.96 | 10.27 | 34 | 109437 | 5235 | 63374316 |
Dysarthria | 19.87 | 10.27 | 134 | 109337 | 42577 | 63336974 |
Catatonia | 19.82 | 10.27 | 31 | 109440 | 4446 | 63375105 |
Dizziness postural | 19.71 | 10.27 | 41 | 109430 | 7335 | 63372216 |
Pneumonitis | 19.66 | 10.27 | 19 | 109452 | 35203 | 63344348 |
Major depression | 19.62 | 10.27 | 43 | 109428 | 7975 | 63371576 |
Grip strength decreased | 19.51 | 10.27 | 7 | 109464 | 22280 | 63357271 |
Premature baby | 19.40 | 10.27 | 79 | 109392 | 20656 | 63358895 |
Antidepressant discontinuation syndrome | 18.77 | 10.27 | 6 | 109465 | 51 | 63379500 |
Therapy interrupted | 18.71 | 10.27 | 17 | 109454 | 32438 | 63347113 |
Right ventricle outflow tract obstruction | 18.69 | 10.27 | 4 | 109467 | 4 | 63379547 |
Foetal movement disorder | 18.69 | 10.27 | 4 | 109467 | 4 | 63379547 |
Arthritis | 18.68 | 10.27 | 120 | 109351 | 115801 | 63263750 |
Velopharyngeal incompetence | 18.62 | 10.27 | 5 | 109466 | 21 | 63379530 |
Drug abuser | 18.50 | 10.27 | 24 | 109447 | 2899 | 63376652 |
Thinking abnormal | 18.47 | 10.27 | 50 | 109421 | 10593 | 63368958 |
Congenital tricuspid valve atresia | 18.45 | 10.27 | 7 | 109464 | 103 | 63379448 |
Mental impairment | 18.39 | 10.27 | 60 | 109411 | 14091 | 63365460 |
Illusion | 18.28 | 10.27 | 15 | 109456 | 1055 | 63378496 |
Bradycardia | 18.28 | 10.27 | 200 | 109271 | 73027 | 63306524 |
Plagiocephaly | 18.18 | 10.27 | 6 | 109465 | 57 | 63379494 |
Blood potassium increased | 18.12 | 10.27 | 71 | 109400 | 18238 | 63361313 |
Frontotemporal dementia | 18.08 | 10.27 | 10 | 109461 | 363 | 63379188 |
Failure to thrive | 18.07 | 10.27 | 39 | 109432 | 7159 | 63372392 |
Cleft lip and palate | 17.83 | 10.27 | 12 | 109459 | 623 | 63378928 |
Anaemia | 17.82 | 10.27 | 378 | 109093 | 293052 | 63086499 |
Granuloma | 17.77 | 10.27 | 34 | 109437 | 5727 | 63373824 |
Congenital aortic anomaly | 17.73 | 10.27 | 6 | 109465 | 62 | 63379489 |
Ear infection | 17.66 | 10.27 | 24 | 109447 | 38189 | 63341362 |
White blood cell count decreased | 17.65 | 10.27 | 154 | 109317 | 138950 | 63240601 |
Impatience | 17.64 | 10.27 | 10 | 109461 | 381 | 63379170 |
Leukopenia | 17.58 | 10.27 | 71 | 109400 | 77219 | 63302332 |
Hypotonia | 17.52 | 10.27 | 45 | 109426 | 9240 | 63370311 |
Psychomotor skills impaired | 17.48 | 10.27 | 21 | 109450 | 2347 | 63377204 |
Therapeutic product effect incomplete | 17.44 | 10.27 | 135 | 109336 | 124921 | 63254630 |
Trismus | 17.34 | 10.27 | 27 | 109444 | 3858 | 63375693 |
Panic disorder | 17.26 | 10.27 | 22 | 109449 | 2611 | 63376940 |
Drug resistance | 17.23 | 10.27 | 9 | 109462 | 22924 | 63356627 |
Premature labour | 17.15 | 10.27 | 54 | 109417 | 12450 | 63367101 |
Mitral valve incompetence | 17.03 | 10.27 | 73 | 109398 | 19521 | 63360030 |
Hospitalisation | 17.02 | 10.27 | 82 | 109389 | 84999 | 63294552 |
Scratch | 16.97 | 10.27 | 36 | 109435 | 6529 | 63373022 |
Sleep disorder | 16.92 | 10.27 | 215 | 109256 | 81351 | 63298200 |
Trichotillomania | 16.91 | 10.27 | 7 | 109464 | 131 | 63379420 |
Campylobacter colitis | 16.87 | 10.27 | 5 | 109466 | 32 | 63379519 |
Tardive dyskinesia | 16.87 | 10.27 | 42 | 109429 | 8460 | 63371091 |
Pulmonary valve incompetence | 16.84 | 10.27 | 16 | 109455 | 1367 | 63378184 |
Cleft uvula | 16.76 | 10.27 | 4 | 109467 | 9 | 63379542 |
Antisocial personality disorder | 16.76 | 10.27 | 4 | 109467 | 9 | 63379542 |
Slow response to stimuli | 16.66 | 10.27 | 14 | 109457 | 1018 | 63378533 |
Myoglobin blood increased | 16.63 | 10.27 | 16 | 109455 | 1389 | 63378162 |
Parkinson's disease | 16.58 | 10.27 | 15 | 109456 | 1204 | 63378347 |
Social avoidant behaviour | 16.56 | 10.27 | 23 | 109448 | 2965 | 63376586 |
Congenital tracheomalacia | 16.37 | 10.27 | 5 | 109466 | 36 | 63379515 |
Feeling guilty | 16.34 | 10.27 | 11 | 109460 | 571 | 63378980 |
Wrong patient | 16.33 | 10.27 | 8 | 109463 | 225 | 63379326 |
Apnoea | 16.31 | 10.27 | 40 | 109431 | 7982 | 63371569 |
Ill-defined disorder | 16.24 | 10.27 | 79 | 109392 | 81676 | 63297875 |
Nodule | 16.17 | 10.27 | 8 | 109463 | 21018 | 63358533 |
Subvalvular aortic stenosis | 16.09 | 10.27 | 3 | 109468 | 0 | 63379551 |
Interruption of aortic arch | 16.09 | 10.27 | 3 | 109468 | 0 | 63379551 |
Lipomeningocele | 16.09 | 10.27 | 3 | 109468 | 0 | 63379551 |
Localised infection | 16.06 | 10.27 | 17 | 109454 | 30193 | 63349358 |
Product use in unapproved indication | 15.99 | 10.27 | 215 | 109256 | 178865 | 63200686 |
Generalised tonic-clonic seizure | 15.96 | 10.27 | 95 | 109376 | 28921 | 63350630 |
Poriomania | 15.96 | 10.27 | 6 | 109465 | 86 | 63379465 |
Blepharospasm | 15.64 | 10.27 | 33 | 109438 | 5963 | 63373588 |
Skin laceration | 15.62 | 10.27 | 79 | 109392 | 22629 | 63356922 |
Feeling abnormal | 15.56 | 10.27 | 350 | 109121 | 148042 | 63231509 |
Post procedural haematuria | 15.49 | 10.27 | 5 | 109466 | 44 | 63379507 |
Otospondylomegaepiphyseal dysplasia | 15.47 | 10.27 | 6 | 109465 | 94 | 63379457 |
Respiratory tract infection | 15.47 | 10.27 | 30 | 109441 | 41453 | 63338098 |
Diabetic hyperosmolar coma | 15.46 | 10.27 | 9 | 109462 | 361 | 63379190 |
Bipolar disorder | 15.46 | 10.27 | 39 | 109432 | 7921 | 63371630 |
Pancytopenia | 15.28 | 10.27 | 101 | 109370 | 96832 | 63282719 |
Chronic spontaneous urticaria | 15.27 | 10.27 | 14 | 109457 | 1143 | 63378408 |
VACTERL syndrome | 15.25 | 10.27 | 4 | 109467 | 15 | 63379536 |
Back pain | 15.25 | 10.27 | 343 | 109128 | 263802 | 63115749 |
Urticaria | 15.19 | 10.27 | 198 | 109273 | 165604 | 63213947 |
Dyslipidaemia | 15.18 | 10.27 | 37 | 109434 | 7356 | 63372195 |
Lactose intolerance | 15.15 | 10.27 | 22 | 109449 | 2956 | 63376595 |
Perseveration | 15.08 | 10.27 | 8 | 109463 | 267 | 63379284 |
Brugada syndrome | 15.06 | 10.27 | 9 | 109462 | 379 | 63379172 |
Arnold-Chiari malformation | 15.02 | 10.27 | 11 | 109460 | 654 | 63378897 |
Alanine aminotransferase increased | 15.02 | 10.27 | 257 | 109214 | 103513 | 63276038 |
Diarrhoea | 14.86 | 10.27 | 1048 | 108423 | 714318 | 62665233 |
Tethered cord syndrome | 14.84 | 10.27 | 8 | 109463 | 276 | 63379275 |
Anhedonia | 14.69 | 10.27 | 47 | 109424 | 10927 | 63368624 |
Gaze palsy | 14.64 | 10.27 | 15 | 109456 | 1405 | 63378146 |
Amimia | 14.58 | 10.27 | 5 | 109466 | 54 | 63379497 |
Antipsychotic drug level above therapeutic | 14.51 | 10.27 | 13 | 109458 | 1030 | 63378521 |
Ear pain | 14.47 | 10.27 | 25 | 109446 | 36093 | 63343458 |
Oesophageal atresia | 14.42 | 10.27 | 10 | 109461 | 545 | 63379006 |
Staphylococcal infection | 14.42 | 10.27 | 121 | 109350 | 41135 | 63338416 |
Female orgasmic disorder | 14.41 | 10.27 | 5 | 109466 | 56 | 63379495 |
Autoimmune nephritis | 14.37 | 10.27 | 9 | 109462 | 413 | 63379138 |
Yawning | 14.12 | 10.27 | 13 | 109458 | 1067 | 63378484 |
Autoimmune disorder | 14.04 | 10.27 | 6 | 109465 | 17171 | 63362380 |
Atrioventricular septal defect | 14.04 | 10.27 | 8 | 109463 | 308 | 63379243 |
Leucine aminopeptidase increased | 14.02 | 10.27 | 3 | 109468 | 3 | 63379548 |
Dyskinesia neonatal | 14.02 | 10.27 | 3 | 109468 | 3 | 63379548 |
Marcus Gunn syndrome | 14.02 | 10.27 | 3 | 109468 | 3 | 63379548 |
Neonatal asphyxia | 14.02 | 10.27 | 8 | 109463 | 309 | 63379242 |
Premature delivery | 14.01 | 10.27 | 19 | 109452 | 30262 | 63349289 |
Oculogyric crisis | 13.93 | 10.27 | 16 | 109455 | 1705 | 63377846 |
Mean cell haemoglobin increased | 13.90 | 10.27 | 21 | 109450 | 2922 | 63376629 |
Wheezing | 13.89 | 10.27 | 102 | 109369 | 95493 | 63284058 |
Wound infection | 13.86 | 10.27 | 10 | 109461 | 21400 | 63358151 |
Tri-iodothyronine free decreased | 13.85 | 10.27 | 8 | 109463 | 316 | 63379235 |
Foetal death | 13.77 | 10.27 | 46 | 109425 | 10934 | 63368617 |
Thrombocytopenia | 13.67 | 10.27 | 181 | 109290 | 150976 | 63228575 |
Oscillopsia | 13.40 | 10.27 | 6 | 109465 | 137 | 63379414 |
Persecutory delusion | 13.31 | 10.27 | 20 | 109451 | 2770 | 63376781 |
Intra-abdominal haematoma | 13.31 | 10.27 | 16 | 109455 | 1789 | 63377762 |
Injection site pruritus | 13.30 | 10.27 | 37 | 109434 | 45079 | 63334472 |
Intentional device use issue | 13.28 | 10.27 | 5 | 109466 | 72 | 63379479 |
Device expulsion | 13.24 | 10.27 | 25 | 109446 | 34897 | 63344654 |
Nasal ulcer | 13.17 | 10.27 | 18 | 109453 | 2286 | 63377265 |
Left ventricular dysfunction | 13.11 | 10.27 | 48 | 109423 | 11940 | 63367611 |
Palpitations | 13.11 | 10.27 | 270 | 109201 | 112500 | 63267051 |
Right aortic arch | 13.10 | 10.27 | 7 | 109464 | 237 | 63379314 |
Drowning | 13.09 | 10.27 | 9 | 109462 | 484 | 63379067 |
Dextrocardia | 13.07 | 10.27 | 4 | 109467 | 29 | 63379522 |
Genital labial adhesions | 13.07 | 10.27 | 4 | 109467 | 29 | 63379522 |
Dairy intolerance | 12.97 | 10.27 | 5 | 109466 | 77 | 63379474 |
Glossoptosis | 12.97 | 10.27 | 5 | 109466 | 77 | 63379474 |
Aeromonas infection | 12.97 | 10.27 | 5 | 109466 | 77 | 63379474 |
Resting tremor | 12.95 | 10.27 | 11 | 109460 | 812 | 63378739 |
Muscle contracture | 12.93 | 10.27 | 14 | 109457 | 1397 | 63378154 |
Hypocoagulable state | 12.90 | 10.27 | 13 | 109458 | 1194 | 63378357 |
Dermatitis allergic | 12.86 | 10.27 | 5 | 109466 | 15143 | 63364408 |
Heterophoria | 12.84 | 10.27 | 4 | 109467 | 31 | 63379520 |
Serum sickness-like reaction | 12.81 | 10.27 | 9 | 109462 | 501 | 63379050 |
Congenital neurological disorder | 12.81 | 10.27 | 3 | 109468 | 6 | 63379545 |
Asplenia | 12.81 | 10.27 | 3 | 109468 | 6 | 63379545 |
Bursitis | 12.79 | 10.27 | 28 | 109443 | 37013 | 63342538 |
Pruritus | 12.71 | 10.27 | 502 | 108969 | 360951 | 63018600 |
Suicidal behaviour | 12.71 | 10.27 | 19 | 109452 | 2620 | 63376931 |
Tenosynovitis | 12.66 | 10.27 | 4 | 109467 | 13791 | 63365760 |
Clostridium difficile infection | 12.65 | 10.27 | 20 | 109451 | 29902 | 63349649 |
Cholecystitis chronic | 12.64 | 10.27 | 43 | 109428 | 10318 | 63369233 |
Reversible cerebral vasoconstriction syndrome | 12.60 | 10.27 | 19 | 109452 | 2639 | 63376912 |
Dissociative disorder | 12.54 | 10.27 | 8 | 109463 | 379 | 63379172 |
Drug-disease interaction | 12.53 | 10.27 | 9 | 109462 | 519 | 63379032 |
Intestinal infarction | 12.51 | 10.27 | 12 | 109459 | 1038 | 63378513 |
Spina bifida occulta | 12.49 | 10.27 | 3 | 109468 | 7 | 63379544 |
Muscle tightness | 12.48 | 10.27 | 47 | 109424 | 11853 | 63367698 |
Marital problem | 12.47 | 10.27 | 6 | 109465 | 162 | 63379389 |
Coronary artery disease | 12.42 | 10.27 | 97 | 109374 | 32280 | 63347271 |
Antiphospholipid antibodies | 12.41 | 10.27 | 6 | 109465 | 164 | 63379387 |
Cognitive disorder | 12.38 | 10.27 | 149 | 109322 | 55666 | 63323885 |
Haemorrhagic diathesis | 12.34 | 10.27 | 25 | 109446 | 4390 | 63375161 |
Laboratory test abnormal | 12.34 | 10.27 | 17 | 109454 | 26895 | 63352656 |
Anal atresia | 12.33 | 10.27 | 8 | 109463 | 390 | 63379161 |
Atrial fibrillation | 12.32 | 10.27 | 135 | 109336 | 116501 | 63263050 |
Ankle fracture | 12.20 | 10.27 | 62 | 109409 | 17793 | 63361758 |
Sacroiliac joint dysfunction | 12.12 | 10.27 | 4 | 109467 | 38 | 63379513 |
Apallic syndrome | 12.09 | 10.27 | 10 | 109461 | 711 | 63378840 |
Epilepsy | 12.05 | 10.27 | 84 | 109387 | 26981 | 63352570 |
Platelet count decreased | 12.03 | 10.27 | 135 | 109336 | 115987 | 63263564 |
Diverticulitis | 12.00 | 10.27 | 32 | 109439 | 39525 | 63340026 |
Electrocardiogram repolarisation abnormality | 11.95 | 10.27 | 13 | 109458 | 1304 | 63378247 |
Inferior vena caval occlusion | 11.95 | 10.27 | 3 | 109468 | 9 | 63379542 |
Paroxysmal arrhythmia | 11.94 | 10.27 | 4 | 109467 | 40 | 63379511 |
Abdominal pain | 11.79 | 10.27 | 401 | 109070 | 293055 | 63086496 |
Abdominal wall cyst | 11.76 | 10.27 | 4 | 109467 | 42 | 63379509 |
Hypoosmolar state | 11.72 | 10.27 | 6 | 109465 | 186 | 63379365 |
Double outlet right ventricle | 11.68 | 10.27 | 4 | 109467 | 43 | 63379508 |
Fluid retention | 11.66 | 10.27 | 58 | 109413 | 59628 | 63319923 |
Affect lability | 11.66 | 10.27 | 44 | 109427 | 11107 | 63368444 |
Vascular access site pain | 11.64 | 10.27 | 5 | 109466 | 103 | 63379448 |
Administration site erythema | 11.58 | 10.27 | 10 | 109461 | 755 | 63378796 |
Sudden death | 11.57 | 10.27 | 42 | 109429 | 10407 | 63369144 |
Posture abnormal | 11.53 | 10.27 | 17 | 109454 | 2315 | 63377236 |
Hypercapnic coma | 11.51 | 10.27 | 6 | 109465 | 193 | 63379358 |
Poor sucking reflex | 11.50 | 10.27 | 7 | 109464 | 305 | 63379246 |
Lupus-like syndrome | 11.49 | 10.27 | 6 | 109465 | 15289 | 63364262 |
Blood aldosterone abnormal | 11.44 | 10.27 | 4 | 109467 | 46 | 63379505 |
Wound complication | 11.42 | 10.27 | 22 | 109449 | 3725 | 63375826 |
Subdural haematoma | 11.41 | 10.27 | 52 | 109419 | 14276 | 63365275 |
Vitamin B12 deficiency | 11.38 | 10.27 | 27 | 109444 | 5276 | 63374275 |
Hepatitis fulminant | 11.38 | 10.27 | 21 | 109450 | 3443 | 63376108 |
Mutism | 11.29 | 10.27 | 14 | 109457 | 1616 | 63377935 |
Delivery | 11.28 | 10.27 | 13 | 109458 | 1390 | 63378161 |
Decreased activity | 11.28 | 10.27 | 30 | 109441 | 6290 | 63373261 |
Aortic stenosis | 11.25 | 10.27 | 26 | 109445 | 4994 | 63374557 |
Diet refusal | 11.24 | 10.27 | 9 | 109462 | 611 | 63378940 |
Cystocele | 11.21 | 10.27 | 12 | 109459 | 1182 | 63378369 |
Vasculitis | 11.15 | 10.27 | 9 | 109462 | 18200 | 63361351 |
Palmar-plantar erythrodysaesthesia syndrome | 11.10 | 10.27 | 14 | 109457 | 23001 | 63356550 |
Pharyngitis | 11.09 | 10.27 | 11 | 109460 | 20132 | 63359419 |
Vulvovaginal pruritus | 11.08 | 10.27 | 20 | 109451 | 3223 | 63376328 |
Congenital diaphragmatic hernia | 11.00 | 10.27 | 6 | 109465 | 212 | 63379339 |
Blood cholinesterase decreased | 10.90 | 10.27 | 5 | 109466 | 121 | 63379430 |
Hyperventilation | 10.88 | 10.27 | 29 | 109442 | 6087 | 63373464 |
Congenital pulmonary valve disorder | 10.79 | 10.27 | 4 | 109467 | 55 | 63379496 |
Congenital eye disorder | 10.75 | 10.27 | 3 | 109468 | 15 | 63379536 |
Mental status changes | 10.74 | 10.27 | 110 | 109361 | 39489 | 63340062 |
Postural tremor | 10.74 | 10.27 | 7 | 109464 | 344 | 63379207 |
Ventricular tachycardia | 10.72 | 10.27 | 65 | 109406 | 19914 | 63359637 |
Posturing | 10.66 | 10.27 | 8 | 109463 | 494 | 63379057 |
Neoplasm progression | 10.65 | 10.27 | 30 | 109441 | 36398 | 63343153 |
Disorganised speech | 10.64 | 10.27 | 12 | 109459 | 1253 | 63378298 |
Communication disorder | 10.64 | 10.27 | 17 | 109454 | 2483 | 63377068 |
Housebound | 10.60 | 10.27 | 6 | 109465 | 228 | 63379323 |
Economic problem | 10.58 | 10.27 | 15 | 109456 | 1971 | 63377580 |
Laryngomalacia | 10.53 | 10.27 | 4 | 109467 | 59 | 63379492 |
Head titubation | 10.49 | 10.27 | 10 | 109461 | 858 | 63378693 |
Osteoporosis | 10.48 | 10.27 | 57 | 109414 | 57281 | 63322270 |
Cerebral haematoma | 10.47 | 10.27 | 21 | 109450 | 3662 | 63375889 |
Hypochloraemia | 10.45 | 10.27 | 15 | 109456 | 1994 | 63377557 |
Normetanephrine urine increased | 10.43 | 10.27 | 3 | 109468 | 17 | 63379534 |
Parkinsonian gait | 10.42 | 10.27 | 8 | 109463 | 511 | 63379040 |
Congenital scoliosis | 10.35 | 10.27 | 4 | 109467 | 62 | 63379489 |
Infusion site scar | 10.35 | 10.27 | 8 | 109463 | 516 | 63379035 |
Hydrocephalus | 10.33 | 10.27 | 26 | 109445 | 5274 | 63374277 |
Hyperthermia | 10.30 | 10.27 | 37 | 109434 | 9119 | 63370432 |
Granuloma skin | 10.28 | 10.27 | 35 | 109436 | 8402 | 63371149 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Exposure during pregnancy | 1837.68 | 11.53 | 641 | 53284 | 8293 | 34894713 |
Atrial septal defect | 826.73 | 11.53 | 340 | 53585 | 7052 | 34895954 |
Ventricular septal defect | 554.96 | 11.53 | 215 | 53710 | 3786 | 34899220 |
Patent ductus arteriosus | 496.53 | 11.53 | 189 | 53736 | 3165 | 34899841 |
Foetal exposure during pregnancy | 446.32 | 11.53 | 410 | 53515 | 37691 | 34865315 |
Drug withdrawal syndrome | 411.57 | 11.53 | 298 | 53627 | 19536 | 34883470 |
Cardiac murmur | 345.78 | 11.53 | 190 | 53735 | 7647 | 34895359 |
Congenital anomaly | 309.49 | 11.53 | 106 | 53819 | 1287 | 34901719 |
Suicidal ideation | 305.10 | 11.53 | 343 | 53582 | 40045 | 34862961 |
Serotonin syndrome | 300.91 | 11.53 | 248 | 53677 | 19685 | 34883321 |
Heart disease congenital | 252.29 | 11.53 | 91 | 53834 | 1299 | 34901707 |
Multiple congenital abnormalities | 251.29 | 11.53 | 73 | 53852 | 491 | 34902515 |
Suicide attempt | 240.40 | 11.53 | 299 | 53626 | 38817 | 34864189 |
Pulmonary valve stenosis | 238.84 | 11.53 | 64 | 53861 | 305 | 34902701 |
Anxiety | 228.91 | 11.53 | 486 | 53439 | 98942 | 34804064 |
Aggression | 225.41 | 11.53 | 289 | 53636 | 38675 | 34864331 |
Talipes | 223.58 | 11.53 | 91 | 53834 | 1832 | 34901174 |
Irritability | 213.06 | 11.53 | 225 | 53700 | 24465 | 34878541 |
Coarctation of the aorta | 191.94 | 11.53 | 57 | 53868 | 418 | 34902588 |
Completed suicide | 188.00 | 11.53 | 446 | 53479 | 97722 | 34805284 |
Persistent foetal circulation | 174.91 | 11.53 | 50 | 53875 | 315 | 34902691 |
Bicuspid aortic valve | 164.22 | 11.53 | 43 | 53882 | 184 | 34902822 |
Pulmonary artery stenosis congenital | 163.46 | 11.53 | 51 | 53874 | 450 | 34902556 |
Hypoplastic left heart syndrome | 162.02 | 11.53 | 43 | 53882 | 196 | 34902810 |
Fallot's tetralogy | 151.85 | 11.53 | 39 | 53886 | 152 | 34902854 |
Transposition of the great vessels | 133.39 | 11.53 | 43 | 53882 | 426 | 34902580 |
Agitation | 132.40 | 11.53 | 281 | 53644 | 57118 | 34845888 |
Poisoning deliberate | 121.26 | 11.53 | 99 | 53826 | 7745 | 34895261 |
Off label use | 120.78 | 11.53 | 296 | 53629 | 419228 | 34483778 |
Congenital aortic stenosis | 118.94 | 11.53 | 28 | 53897 | 68 | 34902938 |
Tremor | 117.65 | 11.53 | 336 | 53589 | 82251 | 34820755 |
Extrapyramidal disorder | 117.57 | 11.53 | 121 | 53804 | 12759 | 34890247 |
Mania | 114.43 | 11.53 | 104 | 53821 | 9407 | 34893599 |
Insomnia | 106.16 | 11.53 | 377 | 53548 | 103530 | 34799476 |
Coma | 105.75 | 11.53 | 224 | 53701 | 45454 | 34857552 |
Sopor | 105.37 | 11.53 | 111 | 53814 | 12025 | 34890981 |
Febrile neutropenia | 104.84 | 11.53 | 40 | 53885 | 136809 | 34766197 |
Intentional self-injury | 103.95 | 11.53 | 117 | 53808 | 13654 | 34889352 |
Impulsive behaviour | 102.52 | 11.53 | 55 | 53870 | 2107 | 34900899 |
Panic attack | 101.63 | 11.53 | 97 | 53828 | 9335 | 34893671 |
Drug abuse | 100.76 | 11.53 | 359 | 53566 | 98737 | 34804269 |
Depression | 98.93 | 11.53 | 352 | 53573 | 96746 | 34806260 |
Activation syndrome | 97.53 | 11.53 | 24 | 53901 | 75 | 34902931 |
Developmental delay | 97.47 | 11.53 | 58 | 53867 | 2717 | 34900289 |
Craniosynostosis | 96.59 | 11.53 | 32 | 53893 | 348 | 34902658 |
Intentional overdose | 95.17 | 11.53 | 209 | 53716 | 43465 | 34859541 |
Neuroleptic malignant syndrome | 94.31 | 11.53 | 127 | 53798 | 17807 | 34885199 |
Disturbance in attention | 89.64 | 11.53 | 151 | 53774 | 25794 | 34877212 |
Congenital cardiovascular anomaly | 85.19 | 11.53 | 25 | 53900 | 175 | 34902831 |
Homicide | 83.98 | 11.53 | 37 | 53888 | 912 | 34902094 |
Somnolence | 82.64 | 11.53 | 365 | 53560 | 110751 | 34792255 |
Withdrawal syndrome | 79.32 | 11.53 | 97 | 53828 | 12358 | 34890648 |
Anger | 78.04 | 11.53 | 94 | 53831 | 11790 | 34891216 |
Pneumonia | 76.28 | 11.53 | 295 | 53630 | 362332 | 34540674 |
Sexual dysfunction | 72.08 | 11.53 | 67 | 53858 | 6236 | 34896770 |
Acute kidney injury | 70.11 | 11.53 | 239 | 53686 | 304749 | 34598257 |
Double outlet right ventricle | 68.57 | 11.53 | 19 | 53906 | 105 | 34902901 |
Confusional state | 67.27 | 11.53 | 416 | 53509 | 143744 | 34759262 |
Congenital aortic atresia | 66.49 | 11.53 | 14 | 53911 | 15 | 34902991 |
Mood swings | 61.11 | 11.53 | 68 | 53857 | 7833 | 34895173 |
Pulmonary malformation | 61.00 | 11.53 | 14 | 53911 | 29 | 34902977 |
Cogwheel rigidity | 60.22 | 11.53 | 33 | 53892 | 1319 | 34901687 |
Death | 59.76 | 11.53 | 365 | 53560 | 397684 | 34505322 |
Hypoplastic right heart syndrome | 58.45 | 11.53 | 12 | 53913 | 10 | 34902996 |
Sleep disorder | 58.39 | 11.53 | 142 | 53783 | 31546 | 34871460 |
Head titubation | 56.67 | 11.53 | 22 | 53903 | 389 | 34902617 |
Cleft palate | 56.60 | 11.53 | 25 | 53900 | 620 | 34902386 |
Tricuspid valve incompetence | 55.76 | 11.53 | 72 | 53853 | 9688 | 34893318 |
Sepsis | 55.54 | 11.53 | 108 | 53817 | 166453 | 34736553 |
Drug ineffective | 54.80 | 11.53 | 447 | 53478 | 456304 | 34446702 |
Speech disorder developmental | 54.80 | 11.53 | 37 | 53888 | 2163 | 34900843 |
Erectile dysfunction | 53.39 | 11.53 | 106 | 53819 | 20531 | 34882475 |
Inappropriate antidiuretic hormone secretion | 53.34 | 11.53 | 81 | 53844 | 12672 | 34890334 |
Drug withdrawal syndrome neonatal | 52.44 | 11.53 | 44 | 53881 | 3575 | 34899431 |
Ventricular hypoplasia | 51.52 | 11.53 | 14 | 53911 | 71 | 34902935 |
Cleft lip and palate | 51.25 | 11.53 | 26 | 53899 | 886 | 34902120 |
Nervousness | 51.22 | 11.53 | 79 | 53846 | 12527 | 34890479 |
Visceral congestion | 50.75 | 11.53 | 23 | 53902 | 607 | 34902399 |
Disease progression | 49.74 | 11.53 | 56 | 53869 | 108021 | 34794985 |
Overdose | 49.71 | 11.53 | 274 | 53651 | 90785 | 34812221 |
Hyperhidrosis | 49.10 | 11.53 | 239 | 53686 | 75453 | 34827553 |
Arnold-Chiari malformation | 48.99 | 11.53 | 19 | 53906 | 335 | 34902671 |
Pulmonary valve stenosis congenital | 48.62 | 11.53 | 15 | 53910 | 127 | 34902879 |
Anticholinergic syndrome | 48.46 | 11.53 | 28 | 53897 | 1241 | 34901765 |
Diarrhoea | 47.44 | 11.53 | 380 | 53545 | 389532 | 34513474 |
Plagiocephaly | 47.31 | 11.53 | 21 | 53904 | 527 | 34902479 |
Hamartoma | 47.29 | 11.53 | 12 | 53913 | 44 | 34902962 |
Congenital aortic valve incompetence | 46.14 | 11.53 | 15 | 53910 | 153 | 34902853 |
Gun shot wound | 46.05 | 11.53 | 26 | 53899 | 1102 | 34901904 |
Maternal drugs affecting foetus | 45.05 | 11.53 | 42 | 53883 | 3923 | 34899083 |
Dyspnoea | 43.63 | 11.53 | 372 | 53553 | 376410 | 34526596 |
Tremor neonatal | 43.25 | 11.53 | 18 | 53907 | 384 | 34902622 |
Congenital tricuspid valve atresia | 43.12 | 11.53 | 13 | 53912 | 101 | 34902905 |
Libido decreased | 42.63 | 11.53 | 44 | 53881 | 4652 | 34898354 |
Ejaculation delayed | 42.12 | 11.53 | 16 | 53909 | 266 | 34902740 |
Drug dependence | 41.95 | 11.53 | 106 | 53819 | 24111 | 34878895 |
Thinking abnormal | 41.04 | 11.53 | 49 | 53876 | 6088 | 34896918 |
Attention deficit hyperactivity disorder | 41.03 | 11.53 | 33 | 53892 | 2526 | 34900480 |
Toxicity to various agents | 40.64 | 11.53 | 480 | 53445 | 199882 | 34703124 |
Restlessness | 40.51 | 11.53 | 108 | 53817 | 25374 | 34877632 |
Right aortic arch | 40.48 | 11.53 | 9 | 53916 | 15 | 34902991 |
COVID-19 | 40.46 | 11.53 | 36 | 53889 | 77514 | 34825492 |
Depressed mood | 40.43 | 11.53 | 91 | 53834 | 19226 | 34883780 |
Hangover | 39.63 | 11.53 | 23 | 53902 | 1028 | 34901978 |
Hyperreflexia | 38.44 | 11.53 | 35 | 53890 | 3171 | 34899835 |
Abdominal pain | 38.32 | 11.53 | 127 | 53798 | 163491 | 34739515 |
Abnormal behaviour | 37.86 | 11.53 | 104 | 53821 | 24865 | 34878141 |
Mitral valve stenosis | 37.69 | 11.53 | 15 | 53910 | 284 | 34902722 |
Nightmare | 37.32 | 11.53 | 74 | 53851 | 14317 | 34888689 |
Rash | 37.22 | 11.53 | 197 | 53728 | 222555 | 34680451 |
Pyrexia | 37.09 | 11.53 | 332 | 53593 | 332681 | 34570325 |
Anaemia | 37.00 | 11.53 | 210 | 53715 | 233125 | 34669881 |
Thrombocytopenia | 36.78 | 11.53 | 121 | 53804 | 156126 | 34746880 |
Bipolar disorder | 36.27 | 11.53 | 36 | 53889 | 3633 | 34899373 |
Affect lability | 36.16 | 11.53 | 36 | 53889 | 3647 | 34899359 |
Mydriasis | 36.15 | 11.53 | 50 | 53875 | 7187 | 34895819 |
Malignant neoplasm progression | 35.92 | 11.53 | 50 | 53875 | 87996 | 34815010 |
Feeling of despair | 35.83 | 11.53 | 21 | 53904 | 956 | 34902050 |
Somnolence neonatal | 35.04 | 11.53 | 8 | 53917 | 16 | 34902990 |
Infection | 34.78 | 11.53 | 54 | 53871 | 90861 | 34812145 |
Intentional product use issue | 34.67 | 11.53 | 25 | 53900 | 59791 | 34843215 |
Akathisia | 34.61 | 11.53 | 52 | 53873 | 8057 | 34894949 |
Parkinsonism | 34.47 | 11.53 | 52 | 53873 | 8086 | 34894920 |
Memory impairment | 34.21 | 11.53 | 145 | 53780 | 43173 | 34859833 |
Right ventricular hypertrophy | 33.97 | 11.53 | 24 | 53901 | 1510 | 34901496 |
Dextrocardia | 33.94 | 11.53 | 11 | 53914 | 111 | 34902895 |
Disorientation | 33.46 | 11.53 | 120 | 53805 | 33068 | 34869938 |
Altered state of consciousness | 33.37 | 11.53 | 94 | 53831 | 22799 | 34880207 |
General physical health deterioration | 33.26 | 11.53 | 95 | 53830 | 128174 | 34774832 |
Hyperthermia | 33.17 | 11.53 | 59 | 53866 | 10518 | 34892488 |
Neutropenia | 33.17 | 11.53 | 127 | 53798 | 156651 | 34746355 |
Agoraphobia | 33.02 | 11.53 | 13 | 53912 | 239 | 34902767 |
Amnesia | 32.95 | 11.53 | 103 | 53822 | 26460 | 34876546 |
DiGeorge's syndrome | 32.86 | 11.53 | 6 | 53919 | 0 | 34903006 |
Interruption of aortic arch | 32.86 | 11.53 | 6 | 53919 | 0 | 34903006 |
Hypomania | 32.78 | 11.53 | 28 | 53897 | 2331 | 34900675 |
Hypospadias | 32.75 | 11.53 | 32 | 53893 | 3169 | 34899837 |
Congenital aortic anomaly | 32.69 | 11.53 | 10 | 53915 | 82 | 34902924 |
Choanal atresia | 32.56 | 11.53 | 7 | 53918 | 9 | 34902997 |
Anencephaly | 32.53 | 11.53 | 11 | 53914 | 128 | 34902878 |
Oral discharge | 32.45 | 11.53 | 11 | 53914 | 129 | 34902877 |
Renal impairment | 31.71 | 11.53 | 61 | 53864 | 94452 | 34808554 |
Homicidal ideation | 31.61 | 11.53 | 29 | 53896 | 2653 | 34900353 |
Cough | 31.52 | 11.53 | 122 | 53803 | 150018 | 34752988 |
Congenital scoliosis | 31.49 | 11.53 | 10 | 53915 | 94 | 34902912 |
Congenital pulmonary artery anomaly | 31.36 | 11.53 | 7 | 53918 | 12 | 34902994 |
Muscle rigidity | 30.86 | 11.53 | 57 | 53868 | 10461 | 34892545 |
Product use issue | 29.90 | 11.53 | 32 | 53893 | 63184 | 34839822 |
Depressed level of consciousness | 29.74 | 11.53 | 138 | 53787 | 42703 | 34860303 |
Pancytopenia | 29.73 | 11.53 | 64 | 53861 | 95093 | 34807913 |
Emotional distress | 29.47 | 11.53 | 69 | 53856 | 14957 | 34888049 |
Treatment failure | 29.10 | 11.53 | 18 | 53907 | 46679 | 34856327 |
Vertigo | 28.94 | 11.53 | 96 | 53829 | 25440 | 34877566 |
Drug abuser | 28.82 | 11.53 | 33 | 53892 | 3921 | 34899085 |
Verbal abuse | 28.20 | 11.53 | 11 | 53914 | 197 | 34902809 |
Congenital genitourinary abnormality | 28.17 | 11.53 | 8 | 53917 | 49 | 34902957 |
Epistaxis | 28.10 | 11.53 | 29 | 53896 | 58222 | 34844784 |
Atrial fibrillation | 27.95 | 11.53 | 96 | 53829 | 122297 | 34780709 |
Physical assault | 27.91 | 11.53 | 19 | 53906 | 1126 | 34901880 |
Hyper IgE syndrome | 27.38 | 11.53 | 8 | 53917 | 55 | 34902951 |
Ebstein's anomaly | 27.38 | 11.53 | 5 | 53920 | 0 | 34903006 |
Abdominal transposition | 27.38 | 11.53 | 5 | 53920 | 0 | 34903006 |
Congenital mitral valve stenosis | 27.38 | 11.53 | 5 | 53920 | 0 | 34903006 |
Developmental hip dysplasia | 27.34 | 11.53 | 12 | 53913 | 293 | 34902713 |
Congenital coronary artery malformation | 27.14 | 11.53 | 8 | 53917 | 57 | 34902949 |
Cytomegalovirus infection | 27.09 | 11.53 | 4 | 53921 | 26131 | 34876875 |
Product use in unapproved indication | 26.94 | 11.53 | 92 | 53833 | 117407 | 34785599 |
Multiple cardiac defects | 26.66 | 11.53 | 8 | 53917 | 61 | 34902945 |
Asphyxia | 26.60 | 11.53 | 42 | 53883 | 6793 | 34896213 |
Selective eating disorder | 26.55 | 11.53 | 22 | 53903 | 1756 | 34901250 |
Cleft lip | 26.19 | 11.53 | 12 | 53913 | 325 | 34902681 |
Myoclonus | 26.07 | 11.53 | 65 | 53860 | 14660 | 34888346 |
Ejaculation failure | 26.07 | 11.53 | 16 | 53909 | 793 | 34902213 |
C-reactive protein increased | 26.01 | 11.53 | 27 | 53898 | 54071 | 34848935 |
Blepharospasm | 25.66 | 11.53 | 18 | 53907 | 1120 | 34901886 |
Vascular stenosis | 25.49 | 11.53 | 10 | 53915 | 182 | 34902824 |
Paraesthesia | 25.49 | 11.53 | 178 | 53747 | 63994 | 34839012 |
Autism spectrum disorder | 25.47 | 11.53 | 24 | 53901 | 2272 | 34900734 |
Joint swelling | 25.45 | 11.53 | 33 | 53892 | 59857 | 34843149 |
Respiratory acidosis | 25.38 | 11.53 | 35 | 53890 | 5015 | 34897991 |
Congenital hand malformation | 25.07 | 11.53 | 14 | 53911 | 581 | 34902425 |
Bronchopulmonary dysplasia | 25 | 11.53 | 14 | 53911 | 584 | 34902422 |
Delirium | 24.39 | 11.53 | 133 | 53792 | 43858 | 34859148 |
Paranoia | 24.30 | 11.53 | 56 | 53869 | 12012 | 34890994 |
Pulmonary valve incompetence | 24.20 | 11.53 | 16 | 53909 | 903 | 34902103 |
Neural tube defect | 24.10 | 11.53 | 7 | 53918 | 47 | 34902959 |
Pulmonary artery stenosis | 24.01 | 11.53 | 11 | 53914 | 298 | 34902708 |
Subgaleal haematoma | 23.82 | 11.53 | 8 | 53917 | 91 | 34902915 |
Blood creatine phosphokinase increased | 23.79 | 11.53 | 134 | 53791 | 44723 | 34858283 |
Septic shock | 23.54 | 11.53 | 47 | 53878 | 71787 | 34831219 |
Emotional disorder | 23.47 | 11.53 | 36 | 53889 | 5680 | 34897326 |
Resting tremor | 23.29 | 11.53 | 14 | 53911 | 668 | 34902338 |
Hepatic enzyme increased | 23.08 | 11.53 | 16 | 53909 | 39064 | 34863942 |
Seizure | 22.91 | 11.53 | 255 | 53670 | 104602 | 34798404 |
Truncus arteriosus persistent | 22.85 | 11.53 | 6 | 53919 | 26 | 34902980 |
Ascites | 22.67 | 11.53 | 23 | 53902 | 46548 | 34856458 |
Peripheral swelling | 22.66 | 11.53 | 53 | 53872 | 76488 | 34826518 |
Aortic valve incompetence | 22.59 | 11.53 | 36 | 53889 | 5868 | 34897138 |
Neonatal asphyxia | 22.55 | 11.53 | 11 | 53914 | 344 | 34902662 |
Logorrhoea | 22.51 | 11.53 | 23 | 53902 | 2403 | 34900603 |
Sedation complication | 22.49 | 11.53 | 20 | 53905 | 1757 | 34901249 |
Congenital hydronephrosis | 22.36 | 11.53 | 14 | 53911 | 719 | 34902287 |
Congenital tracheomalacia | 22.25 | 11.53 | 5 | 53920 | 9 | 34902997 |
Platelet count decreased | 22.19 | 11.53 | 102 | 53823 | 119615 | 34783391 |
Congenital diaphragmatic hernia | 22.17 | 11.53 | 10 | 53915 | 261 | 34902745 |
Spina bifida | 22.15 | 11.53 | 11 | 53914 | 358 | 34902648 |
Cardiomegaly | 22.12 | 11.53 | 63 | 53862 | 15375 | 34887631 |
Erythema | 22.10 | 11.53 | 67 | 53858 | 88713 | 34814293 |
Judgement impaired | 22.04 | 11.53 | 13 | 53912 | 599 | 34902407 |
Mood altered | 21.98 | 11.53 | 45 | 53880 | 8907 | 34894099 |
Mitral valve atresia | 21.90 | 11.53 | 4 | 53921 | 0 | 34903006 |
Idiosyncratic alcohol intoxication | 21.90 | 11.53 | 4 | 53921 | 0 | 34903006 |
Porencephaly | 21.90 | 11.53 | 4 | 53921 | 0 | 34903006 |
Noonan syndrome | 21.90 | 11.53 | 4 | 53921 | 0 | 34903006 |
Sleep apnoea syndrome | 21.79 | 11.53 | 75 | 53850 | 20246 | 34882760 |
Agitation neonatal | 21.65 | 11.53 | 16 | 53909 | 1080 | 34901926 |
Dystonia | 21.48 | 11.53 | 50 | 53875 | 10795 | 34892211 |
Hyperarousal | 21.24 | 11.53 | 6 | 53919 | 36 | 34902970 |
Infantile apnoea | 21.20 | 11.53 | 15 | 53910 | 946 | 34902060 |
Prostate cancer | 21.16 | 11.53 | 18 | 53907 | 39631 | 34863375 |
Bradykinesia | 21.12 | 11.53 | 28 | 53897 | 3865 | 34899141 |
Chemical submission | 21.10 | 11.53 | 6 | 53919 | 37 | 34902969 |
Dyskinesia | 20.87 | 11.53 | 79 | 53846 | 22334 | 34880672 |
Self esteem decreased | 20.87 | 11.53 | 12 | 53913 | 527 | 34902479 |
Illusion | 20.82 | 11.53 | 14 | 53911 | 813 | 34902193 |
Tearfulness | 20.70 | 11.53 | 23 | 53902 | 2644 | 34900362 |
Wolff-Parkinson-White syndrome | 20.61 | 11.53 | 9 | 53916 | 217 | 34902789 |
Ejaculation disorder | 20.54 | 11.53 | 15 | 53910 | 994 | 34902012 |
Intention tremor | 20.49 | 11.53 | 11 | 53914 | 422 | 34902584 |
Pneumocystis jirovecii pneumonia | 20.46 | 11.53 | 3 | 53922 | 19707 | 34883299 |
Congenital pulmonary hypertension | 20.36 | 11.53 | 7 | 53918 | 86 | 34902920 |
Ventricular hypertrophy | 20.32 | 11.53 | 30 | 53895 | 4577 | 34898429 |
Flat affect | 20.26 | 11.53 | 14 | 53911 | 850 | 34902156 |
Somatic dysfunction | 20.23 | 11.53 | 5 | 53920 | 16 | 34902990 |
Haemoglobin decreased | 20.03 | 11.53 | 107 | 53818 | 120665 | 34782341 |
Congenital hydrocephalus | 20.00 | 11.53 | 7 | 53918 | 91 | 34902915 |
Reversible cerebral vasoconstriction syndrome | 19.93 | 11.53 | 11 | 53914 | 446 | 34902560 |
Premature baby | 19.79 | 11.53 | 71 | 53854 | 19562 | 34883444 |
Derealisation | 19.73 | 11.53 | 12 | 53913 | 585 | 34902421 |
Congenital flat feet | 19.67 | 11.53 | 4 | 53921 | 3 | 34903003 |
Gastroschisis | 19.47 | 11.53 | 8 | 53917 | 165 | 34902841 |
Decreased interest | 19.44 | 11.53 | 21 | 53904 | 2339 | 34900667 |
Psychotic disorder | 19.41 | 11.53 | 82 | 53843 | 24370 | 34878636 |
Cerebrovascular stenosis | 19.27 | 11.53 | 7 | 53918 | 102 | 34902904 |
Dysmorphism | 19.16 | 11.53 | 24 | 53901 | 3132 | 34899874 |
Infantile back arching | 19.14 | 11.53 | 4 | 53921 | 4 | 34903002 |
Tension | 19.06 | 11.53 | 20 | 53905 | 2155 | 34900851 |
Clumsiness | 19.01 | 11.53 | 18 | 53907 | 1714 | 34901292 |
Mitral valve prolapse | 19.00 | 11.53 | 12 | 53913 | 626 | 34902380 |
Scaphocephaly | 18.98 | 11.53 | 5 | 53920 | 22 | 34902984 |
Mucosal inflammation | 18.88 | 11.53 | 19 | 53906 | 38603 | 34864403 |
Transient tachypnoea of the newborn | 18.83 | 11.53 | 8 | 53917 | 180 | 34902826 |
Crying | 18.77 | 11.53 | 33 | 53892 | 5829 | 34897177 |
Cytokine release syndrome | 18.67 | 11.53 | 6 | 53919 | 22871 | 34880135 |
Psychiatric symptom | 18.65 | 11.53 | 25 | 53900 | 3488 | 34899518 |
Delusion | 18.53 | 11.53 | 52 | 53873 | 12583 | 34890423 |
Abnormal dreams | 18.49 | 11.53 | 38 | 53887 | 7540 | 34895466 |
Hallucination, auditory | 18.42 | 11.53 | 50 | 53875 | 11867 | 34891139 |
Tonic convulsion | 18.23 | 11.53 | 15 | 53910 | 1186 | 34901820 |
Arthralgia | 18.22 | 11.53 | 171 | 53754 | 169870 | 34733136 |
Speech disorder | 18.01 | 11.53 | 83 | 53842 | 25603 | 34877403 |
Infusion related reaction | 18.00 | 11.53 | 34 | 53891 | 53023 | 34849983 |
Hospitalisation | 17.99 | 11.53 | 38 | 53887 | 56864 | 34846142 |
Oedema peripheral | 17.79 | 11.53 | 110 | 53815 | 119702 | 34783304 |
Tricuspid valve disease | 17.73 | 11.53 | 8 | 53917 | 209 | 34902797 |
Ammonia abnormal | 17.65 | 11.53 | 6 | 53919 | 71 | 34902935 |
Plasmodium vivax infection | 17.52 | 11.53 | 4 | 53921 | 8 | 34902998 |
Neoplasm progression | 17.50 | 11.53 | 7 | 53918 | 23293 | 34879713 |
Renal dysplasia | 17.48 | 11.53 | 8 | 53917 | 216 | 34902790 |
Maternal exposure during pregnancy | 17.48 | 11.53 | 29 | 53896 | 4889 | 34898117 |
Hypersensitivity | 17.48 | 11.53 | 43 | 53882 | 60992 | 34842014 |
Alcohol interaction | 17.44 | 11.53 | 22 | 53903 | 2891 | 34900115 |
Caesarean section | 17.38 | 11.53 | 19 | 53906 | 2145 | 34900861 |
Cardiac failure | 17.35 | 11.53 | 77 | 53848 | 91171 | 34811835 |
Lower respiratory tract infection | 17.33 | 11.53 | 14 | 53911 | 31623 | 34871383 |
Aortic stenosis | 17.27 | 11.53 | 27 | 53898 | 4331 | 34898675 |
Gastrointestinal haemorrhage | 17.22 | 11.53 | 74 | 53851 | 88403 | 34814603 |
Right ventricle outflow tract obstruction | 17.20 | 11.53 | 4 | 53921 | 9 | 34902997 |
Obsessive thoughts | 17.16 | 11.53 | 12 | 53913 | 743 | 34902263 |
Abulia | 17.15 | 11.53 | 11 | 53914 | 589 | 34902417 |
Neutrophil count decreased | 17.12 | 11.53 | 33 | 53892 | 51071 | 34851935 |
Euphoric mood | 17.09 | 11.53 | 31 | 53894 | 5610 | 34897396 |
Chordee | 17.07 | 11.53 | 6 | 53919 | 79 | 34902927 |
Type 2 diabetes mellitus | 17.04 | 11.53 | 59 | 53866 | 15973 | 34887033 |
Opisthotonus | 17.03 | 11.53 | 10 | 53915 | 457 | 34902549 |
Pruritus | 16.88 | 11.53 | 139 | 53786 | 141842 | 34761164 |
Hyperkinesia | 16.84 | 11.53 | 17 | 53908 | 1751 | 34901255 |
Multiple organ dysfunction syndrome | 16.84 | 11.53 | 61 | 53864 | 76505 | 34826501 |
Jaundice neonatal | 16.74 | 11.53 | 15 | 53910 | 1331 | 34901675 |
Neuropathy peripheral | 16.60 | 11.53 | 69 | 53856 | 83194 | 34819812 |
Cyclothymic disorder | 16.54 | 11.53 | 6 | 53919 | 87 | 34902919 |
Neurosis | 16.54 | 11.53 | 7 | 53918 | 156 | 34902850 |
Cryptorchism | 16.53 | 11.53 | 18 | 53907 | 2023 | 34900983 |
Personality disorder | 16.51 | 11.53 | 14 | 53911 | 1154 | 34901852 |
Pulmonary hypoplasia | 16.45 | 11.53 | 10 | 53915 | 487 | 34902519 |
Loss of libido | 16.45 | 11.53 | 20 | 53905 | 2532 | 34900474 |
Congenital Eustachian tube anomaly | 16.43 | 11.53 | 3 | 53922 | 0 | 34903006 |
Congenital pulmonary valve disorder | 16.43 | 11.53 | 3 | 53922 | 0 | 34903006 |
Hypertonia | 16.40 | 11.53 | 26 | 53899 | 4220 | 34898786 |
Abdominal distension | 16.14 | 11.53 | 42 | 53883 | 58450 | 34844556 |
White blood cell count decreased | 16.13 | 11.53 | 84 | 53841 | 95361 | 34807645 |
Pleurothotonus | 16.13 | 11.53 | 14 | 53911 | 1191 | 34901815 |
Plasma cell myeloma | 16.03 | 11.53 | 25 | 53900 | 42012 | 34860994 |
Leukopenia | 15.95 | 11.53 | 47 | 53878 | 62809 | 34840197 |
Dissociation | 15.90 | 11.53 | 16 | 53909 | 1642 | 34901364 |
Renal failure | 15.89 | 11.53 | 127 | 53798 | 130430 | 34772576 |
Colitis | 15.83 | 11.53 | 21 | 53904 | 37729 | 34865277 |
Legal problem | 15.79 | 11.53 | 7 | 53918 | 175 | 34902831 |
Thrombosis | 15.69 | 11.53 | 34 | 53891 | 50424 | 34852582 |
Panic disorder | 15.65 | 11.53 | 14 | 53911 | 1240 | 34901766 |
Inadequate analgesia | 15.53 | 11.53 | 21 | 53904 | 2954 | 34900052 |
Infertility male | 15.51 | 11.53 | 7 | 53918 | 183 | 34902823 |
Epilepsy | 15.48 | 11.53 | 70 | 53855 | 21425 | 34881581 |
Hypotension | 15.34 | 11.53 | 245 | 53680 | 221404 | 34681602 |
Ankyloglossia congenital | 15.34 | 11.53 | 8 | 53917 | 289 | 34902717 |
Vesicoureteric reflux | 15.30 | 11.53 | 7 | 53918 | 189 | 34902817 |
Congenital renal disorder | 15.25 | 11.53 | 6 | 53919 | 110 | 34902896 |
Haemoptysis | 15.17 | 11.53 | 19 | 53906 | 34987 | 34868019 |
Mitral valve incompetence | 15.03 | 11.53 | 54 | 53871 | 14889 | 34888117 |
Drug intolerance | 14.79 | 11.53 | 45 | 53880 | 59525 | 34843481 |
Poisoning | 14.78 | 11.53 | 47 | 53878 | 12179 | 34890827 |
Device breakage | 14.78 | 11.53 | 18 | 53907 | 2282 | 34900724 |
Feeling jittery | 14.76 | 11.53 | 24 | 53901 | 3979 | 34899027 |
Product administration error | 14.72 | 11.53 | 57 | 53868 | 16287 | 34886719 |
Feeling guilty | 14.71 | 11.53 | 8 | 53917 | 315 | 34902691 |
Exomphalos | 14.65 | 11.53 | 7 | 53918 | 209 | 34902797 |
Anaphylactic reaction | 14.56 | 11.53 | 17 | 53908 | 32284 | 34870722 |
Vasoplegia syndrome | 14.40 | 11.53 | 16 | 53909 | 1840 | 34901166 |
Oculoauriculovertebral dysplasia | 14.35 | 11.53 | 3 | 53922 | 3 | 34903003 |
Chronic kidney disease | 14.34 | 11.53 | 26 | 53899 | 41184 | 34861822 |
Hepatocellular injury | 14.29 | 11.53 | 70 | 53855 | 22141 | 34880865 |
Incoherent | 14.17 | 11.53 | 25 | 53900 | 4427 | 34898579 |
Tardive dyskinesia | 14.09 | 11.53 | 29 | 53896 | 5761 | 34897245 |
Sexually transmitted disease | 13.88 | 11.53 | 4 | 53921 | 26 | 34902980 |
Congenital mitral valve incompetence | 13.80 | 11.53 | 6 | 53919 | 143 | 34902863 |
Hepatotoxicity | 13.78 | 11.53 | 8 | 53917 | 21477 | 34881529 |
Contraindicated product administered | 13.77 | 11.53 | 8 | 53917 | 21473 | 34881533 |
Product complaint | 13.75 | 11.53 | 29 | 53896 | 5861 | 34897145 |
Clonus | 13.73 | 11.53 | 19 | 53906 | 2731 | 34900275 |
Loss of consciousness | 13.72 | 11.53 | 191 | 53734 | 82476 | 34820530 |
Obsessive-compulsive disorder | 13.69 | 11.53 | 28 | 53897 | 5536 | 34897470 |
Cerebral palsy | 13.69 | 11.53 | 6 | 53919 | 146 | 34902860 |
Drug screen positive | 13.68 | 11.53 | 23 | 53902 | 3920 | 34899086 |
Therapeutic response decreased | 13.68 | 11.53 | 15 | 53910 | 29298 | 34873708 |
Congenital tricuspid valve incompetence | 13.61 | 11.53 | 6 | 53919 | 148 | 34902858 |
Hallucination, visual | 13.61 | 11.53 | 59 | 53866 | 17732 | 34885274 |
Anomalous pulmonary venous connection | 13.51 | 11.53 | 5 | 53920 | 77 | 34902929 |
Phimosis | 13.51 | 11.53 | 11 | 53914 | 857 | 34902149 |
Apnoea | 13.50 | 11.53 | 31 | 53894 | 6633 | 34896373 |
Pyloric stenosis | 13.44 | 11.53 | 11 | 53914 | 863 | 34902143 |
Asplenia | 13.39 | 11.53 | 5 | 53920 | 79 | 34902927 |
Loss of personal independence in daily activities | 13.36 | 11.53 | 19 | 53906 | 33160 | 34869846 |
Drug interaction | 13.35 | 11.53 | 449 | 53476 | 225497 | 34677509 |
Impulse-control disorder | 13.30 | 11.53 | 13 | 53912 | 1288 | 34901718 |
Cytogenetic abnormality | 13.21 | 11.53 | 11 | 53914 | 884 | 34902122 |
Failure to thrive | 13.21 | 11.53 | 36 | 53889 | 8565 | 34894441 |
Ventricular tachycardia | 13.08 | 11.53 | 13 | 53912 | 26566 | 34876440 |
Basal cell carcinoma | 13.07 | 11.53 | 7 | 53918 | 19651 | 34883355 |
Hypocalcaemia | 12.99 | 11.53 | 11 | 53914 | 24278 | 34878728 |
Hyponatraemia | 12.90 | 11.53 | 189 | 53736 | 82502 | 34820504 |
Brachycephaly | 12.90 | 11.53 | 5 | 53920 | 88 | 34902918 |
Otitis media chronic | 12.90 | 11.53 | 5 | 53920 | 88 | 34902918 |
Hydrocele | 12.88 | 11.53 | 16 | 53909 | 2071 | 34900935 |
Aorta hypoplasia | 12.85 | 11.53 | 5 | 53920 | 89 | 34902917 |
Cognitive disorder | 12.84 | 11.53 | 82 | 53843 | 28611 | 34874395 |
Personality change | 12.81 | 11.53 | 26 | 53899 | 5113 | 34897893 |
Swelling | 12.80 | 11.53 | 29 | 53896 | 42337 | 34860669 |
Eyelid ptosis congenital | 12.70 | 11.53 | 5 | 53920 | 92 | 34902914 |
Palmar-plantar erythrodysaesthesia syndrome | 12.69 | 11.53 | 5 | 53920 | 16790 | 34886216 |
Urinary tract infection | 12.58 | 11.53 | 77 | 53848 | 84004 | 34819002 |
Feeling abnormal | 12.55 | 11.53 | 151 | 53774 | 63084 | 34839922 |
Thought insertion | 12.54 | 11.53 | 3 | 53922 | 8 | 34902998 |
Depersonalisation/derealisation disorder | 12.48 | 11.53 | 9 | 53916 | 585 | 34902421 |
Genital paraesthesia | 12.46 | 11.53 | 4 | 53921 | 39 | 34902967 |
Major depression | 12.45 | 11.53 | 24 | 53901 | 4548 | 34898458 |
Administration related reaction | 12.40 | 11.53 | 5 | 53920 | 98 | 34902908 |
Neutropenic sepsis | 12.37 | 11.53 | 3 | 53922 | 13764 | 34889242 |
Mitral valve disease | 12.35 | 11.53 | 13 | 53912 | 1406 | 34901600 |
Cardio-respiratory arrest | 12.32 | 11.53 | 135 | 53790 | 55138 | 34847868 |
Jealous delusion | 12.20 | 11.53 | 7 | 53918 | 306 | 34902700 |
Eating disorder | 12.17 | 11.53 | 34 | 53891 | 8206 | 34894800 |
Dehydration | 12.14 | 11.53 | 135 | 53790 | 129834 | 34773172 |
Duodenal atresia | 12.04 | 11.53 | 3 | 53922 | 10 | 34902996 |
Microcephaly | 12.04 | 11.53 | 10 | 53915 | 801 | 34902205 |
Exhibitionism | 12.03 | 11.53 | 4 | 53921 | 44 | 34902962 |
Affective disorder | 12.01 | 11.53 | 23 | 53902 | 4337 | 34898669 |
Hypertonia neonatal | 11.98 | 11.53 | 8 | 53917 | 459 | 34902547 |
Nystagmus | 11.93 | 11.53 | 24 | 53901 | 4691 | 34898315 |
Incorrect route of product administration | 11.92 | 11.53 | 4 | 53921 | 14841 | 34888165 |
Hyperventilation | 11.90 | 11.53 | 18 | 53907 | 2806 | 34900200 |
Patient uncooperative | 11.86 | 11.53 | 8 | 53917 | 467 | 34902539 |
Neonatal disorder | 11.84 | 11.53 | 10 | 53915 | 820 | 34902186 |
Limb asymmetry | 11.83 | 11.53 | 5 | 53920 | 111 | 34902895 |
Divorced | 11.82 | 11.53 | 3 | 53922 | 11 | 34902995 |
Cellulitis | 11.76 | 11.53 | 42 | 53883 | 52909 | 34850097 |
Decerebrate posture | 11.72 | 11.53 | 4 | 53921 | 48 | 34902958 |
Herpes zoster | 11.70 | 11.53 | 22 | 53903 | 34377 | 34868629 |
Suspiciousness | 11.68 | 11.53 | 7 | 53918 | 332 | 34902674 |
Device related infection | 11.66 | 11.53 | 6 | 53919 | 17231 | 34885775 |
Persistent depressive disorder | 11.65 | 11.53 | 7 | 53918 | 334 | 34902672 |
Apathy | 11.64 | 11.53 | 30 | 53895 | 6902 | 34896104 |
Psychomotor hyperactivity | 11.64 | 11.53 | 37 | 53888 | 9585 | 34893421 |
Feeling of relaxation | 11.57 | 11.53 | 4 | 53921 | 50 | 34902956 |
Renal salt-wasting syndrome | 11.57 | 11.53 | 7 | 53918 | 338 | 34902668 |
Ventricular fibrillation | 11.56 | 11.53 | 11 | 53914 | 22943 | 34880063 |
Bone marrow failure | 11.54 | 11.53 | 17 | 53908 | 29236 | 34873770 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Serotonin syndrome | 976.89 | 10.33 | 701 | 125014 | 44326 | 79574347 |
Drug withdrawal syndrome | 779.44 | 10.33 | 552 | 125163 | 34166 | 79584507 |
Suicidal ideation | 615.69 | 10.33 | 678 | 125037 | 75662 | 79543011 |
Suicide attempt | 532.32 | 10.33 | 655 | 125060 | 82277 | 79536396 |
Sopor | 511.74 | 10.33 | 421 | 125294 | 32589 | 79586084 |
Drug abuse | 436.01 | 10.33 | 858 | 124857 | 161833 | 79456840 |
Anxiety | 428.36 | 10.33 | 1099 | 124616 | 247413 | 79371260 |
Agitation | 357.61 | 10.33 | 597 | 125118 | 99118 | 79519555 |
Tremor | 339.39 | 10.33 | 796 | 124919 | 169287 | 79449386 |
Completed suicide | 296.18 | 10.33 | 956 | 124759 | 244811 | 79373862 |
Somnolence | 283.80 | 10.33 | 925 | 124790 | 238056 | 79380617 |
Intentional self-injury | 268.24 | 10.33 | 292 | 125423 | 32127 | 79586546 |
Irritability | 260.67 | 10.33 | 323 | 125392 | 40821 | 79577852 |
Drug interaction | 252.43 | 10.33 | 1306 | 124409 | 413877 | 79204796 |
Mydriasis | 246.53 | 10.33 | 212 | 125503 | 17431 | 79601242 |
Mania | 240.22 | 10.33 | 212 | 125503 | 18048 | 79600625 |
Aggression | 225.38 | 10.33 | 336 | 125379 | 50622 | 79568051 |
Neuroleptic malignant syndrome | 222.39 | 10.33 | 245 | 125470 | 27314 | 79591359 |
Off label use | 219.46 | 10.33 | 718 | 124997 | 906497 | 78712176 |
Poisoning deliberate | 213.27 | 10.33 | 201 | 125514 | 18627 | 79600046 |
Confusional state | 204.78 | 10.33 | 1017 | 124698 | 316980 | 79301693 |
Depression | 202.86 | 10.33 | 776 | 124939 | 216014 | 79402659 |
Nightmare | 195.14 | 10.33 | 222 | 125493 | 25639 | 79593034 |
Hyponatraemia | 178.32 | 10.33 | 651 | 125064 | 177197 | 79441476 |
Panic attack | 176.17 | 10.33 | 204 | 125511 | 24012 | 79594661 |
Disorientation | 175.12 | 10.33 | 337 | 125378 | 62439 | 79556234 |
Disturbance in attention | 173.84 | 10.33 | 298 | 125417 | 50503 | 79568170 |
Depersonalisation/derealisation disorder | 171.00 | 10.33 | 75 | 125640 | 1787 | 79616886 |
Derealisation | 163.14 | 10.33 | 70 | 125645 | 1579 | 79617094 |
Activation syndrome | 162.76 | 10.33 | 45 | 125670 | 240 | 79618433 |
Extrapyramidal disorder | 161.55 | 10.33 | 189 | 125526 | 22490 | 79596183 |
Insomnia | 159.06 | 10.33 | 786 | 124929 | 244384 | 79374289 |
Febrile neutropenia | 154.35 | 10.33 | 86 | 125629 | 230913 | 79387760 |
Contraindicated product administered | 153.04 | 10.33 | 31 | 125684 | 157507 | 79461166 |
Mood swings | 148.87 | 10.33 | 170 | 125545 | 19710 | 79598963 |
Toxicity to various agents | 147.27 | 10.33 | 1152 | 124563 | 420388 | 79198285 |
Feeling of despair | 144.19 | 10.33 | 76 | 125639 | 2745 | 79615928 |
Inappropriate antidiuretic hormone secretion | 143.76 | 10.33 | 192 | 125523 | 26121 | 79592552 |
Withdrawal syndrome | 143.74 | 10.33 | 194 | 125521 | 26660 | 79592013 |
Overdose | 143.37 | 10.33 | 623 | 125092 | 183583 | 79435090 |
Intentional overdose | 141.07 | 10.33 | 427 | 125288 | 105533 | 79513140 |
Coma | 141.01 | 10.33 | 413 | 125302 | 100236 | 79518437 |
Bradyphrenia | 140.88 | 10.33 | 124 | 125591 | 10516 | 79608157 |
Anger | 139.20 | 10.33 | 153 | 125562 | 17009 | 79601664 |
Alopecia | 138.22 | 10.33 | 98 | 125617 | 231257 | 79387416 |
Dissociation | 136.85 | 10.33 | 83 | 125632 | 3938 | 79614735 |
Restlessness | 136.36 | 10.33 | 255 | 125460 | 46237 | 79572436 |
Myoglobin urine present | 134.13 | 10.33 | 52 | 125663 | 895 | 79617778 |
Hyperhidrosis | 128.47 | 10.33 | 526 | 125189 | 150966 | 79467707 |
Impulsive behaviour | 128.33 | 10.33 | 71 | 125644 | 2829 | 79615844 |
Cogwheel rigidity | 126.85 | 10.33 | 72 | 125643 | 3016 | 79615657 |
Dyskinesia | 124.42 | 10.33 | 240 | 125475 | 44533 | 79574140 |
Systemic lupus erythematosus | 119.42 | 10.33 | 23 | 125692 | 121126 | 79497547 |
Homicide | 116.19 | 10.33 | 50 | 125665 | 1136 | 79617537 |
Hallucinations, mixed | 113.21 | 10.33 | 91 | 125624 | 6808 | 79611865 |
Drug intolerance | 112.50 | 10.33 | 151 | 125564 | 263968 | 79354705 |
Drug ineffective | 111.18 | 10.33 | 1130 | 124585 | 1079783 | 78538890 |
Glossodynia | 109.87 | 10.33 | 16 | 125699 | 103321 | 79515352 |
Joint swelling | 109.34 | 10.33 | 179 | 125536 | 288467 | 79330206 |
Pericarditis | 106.60 | 10.33 | 18 | 125697 | 104218 | 79514455 |
Gastric pH decreased | 105.77 | 10.33 | 43 | 125672 | 843 | 79617830 |
Synovitis | 100.82 | 10.33 | 56 | 125659 | 150678 | 79467995 |
Hyperreflexia | 97.80 | 10.33 | 91 | 125624 | 8294 | 79610379 |
Delirium | 97.04 | 10.33 | 324 | 125391 | 84303 | 79534370 |
Emotional disorder | 96.04 | 10.33 | 116 | 125599 | 14271 | 79604402 |
Rash | 95.37 | 10.33 | 529 | 125186 | 577829 | 79040844 |
Hallucination, auditory | 95.15 | 10.33 | 139 | 125576 | 20554 | 79598119 |
Drug dependence | 93.67 | 10.33 | 202 | 125513 | 40567 | 79578106 |
Infusion related reaction | 90.75 | 10.33 | 139 | 125576 | 230098 | 79388575 |
Agoraphobia | 89.97 | 10.33 | 34 | 125681 | 544 | 79618129 |
Helicobacter infection | 89.48 | 10.33 | 5 | 125710 | 69699 | 79548974 |
Altered state of consciousness | 89.32 | 10.33 | 207 | 125508 | 43615 | 79575058 |
Muscle rigidity | 89.17 | 10.33 | 132 | 125583 | 19750 | 79598923 |
Nervousness | 86.64 | 10.33 | 174 | 125541 | 33241 | 79585432 |
Memory impairment | 85.42 | 10.33 | 376 | 125339 | 111358 | 79507315 |
Akathisia | 85.41 | 10.33 | 105 | 125610 | 13154 | 79605519 |
Flat affect | 84.95 | 10.33 | 48 | 125667 | 1993 | 79616680 |
Pneumonia | 83.55 | 10.33 | 654 | 125061 | 659592 | 78959081 |
Swelling | 83.34 | 10.33 | 133 | 125582 | 216578 | 79402095 |
Myoclonus | 82.71 | 10.33 | 153 | 125562 | 27507 | 79591166 |
Treatment failure | 82.64 | 10.33 | 88 | 125627 | 170398 | 79448275 |
Bronchial neoplasm | 79.50 | 10.33 | 30 | 125685 | 478 | 79618195 |
Intentional product use issue | 78.91 | 10.33 | 74 | 125641 | 152038 | 79466635 |
Homicidal ideation | 77.61 | 10.33 | 55 | 125660 | 3402 | 79615271 |
Sepsis | 75.83 | 10.33 | 198 | 125517 | 269230 | 79349443 |
Parkinsonism | 75.67 | 10.33 | 111 | 125604 | 16473 | 79602200 |
Abnormal behaviour | 75.28 | 10.33 | 173 | 125542 | 36248 | 79582425 |
Rheumatoid arthritis | 74.58 | 10.33 | 134 | 125581 | 208336 | 79410337 |
Vertigo | 74.38 | 10.33 | 259 | 125456 | 68823 | 79549850 |
Malignant neoplasm progression | 73.11 | 10.33 | 64 | 125651 | 135926 | 79482747 |
Dystonia | 72.49 | 10.33 | 125 | 125590 | 21274 | 79597399 |
Cough | 72.18 | 10.33 | 315 | 125400 | 366474 | 79252199 |
Depressed level of consciousness | 72.17 | 10.33 | 323 | 125392 | 96329 | 79522344 |
Blister | 72.11 | 10.33 | 50 | 125665 | 119426 | 79499247 |
Blood creatine phosphokinase increased | 71.34 | 10.33 | 248 | 125467 | 65842 | 79552831 |
Product use issue | 69.69 | 10.33 | 141 | 125574 | 209681 | 79408992 |
Disease progression | 68.22 | 10.33 | 116 | 125599 | 184246 | 79434427 |
Libido increased | 67.31 | 10.33 | 41 | 125674 | 1960 | 79616713 |
Crying | 67.07 | 10.33 | 126 | 125589 | 22917 | 79595756 |
Libido decreased | 66.45 | 10.33 | 60 | 125655 | 5261 | 79613412 |
Nasal turbinate hypertrophy | 66.31 | 10.33 | 29 | 125686 | 686 | 79617987 |
Feeling jittery | 66.04 | 10.33 | 91 | 125624 | 12750 | 79605923 |
Abdominal discomfort | 65.52 | 10.33 | 191 | 125524 | 250536 | 79368137 |
Stomatitis | 65.44 | 10.33 | 81 | 125634 | 146676 | 79471997 |
COVID-19 | 65.23 | 10.33 | 92 | 125623 | 157582 | 79461091 |
Delusion | 64.91 | 10.33 | 116 | 125599 | 20307 | 79598366 |
Psychotic disorder | 64.90 | 10.33 | 177 | 125538 | 41225 | 79577448 |
Hypersensitivity | 63.40 | 10.33 | 207 | 125508 | 262032 | 79356641 |
Endometrial ablation | 63.19 | 10.33 | 30 | 125685 | 863 | 79617810 |
General physical health deterioration | 62.64 | 10.33 | 223 | 125492 | 275015 | 79343658 |
Clonus | 62.56 | 10.33 | 65 | 125650 | 6775 | 79611898 |
Affective disorder | 62.04 | 10.33 | 71 | 125644 | 8248 | 79610425 |
Speech disorder | 62.00 | 10.33 | 208 | 125507 | 54237 | 79564436 |
Hepatic enzyme increased | 61.25 | 10.33 | 122 | 125593 | 182488 | 79436185 |
H1N1 influenza | 61.04 | 10.33 | 42 | 125673 | 2477 | 79616196 |
Peripheral swelling | 60.33 | 10.33 | 220 | 125495 | 269397 | 79349276 |
Tearfulness | 59.94 | 10.33 | 60 | 125655 | 5985 | 79612688 |
Emotional distress | 57.86 | 10.33 | 166 | 125549 | 39803 | 79578870 |
Fall | 57.67 | 10.33 | 1084 | 124631 | 486545 | 79132128 |
Drooling | 57.19 | 10.33 | 58 | 125657 | 5876 | 79612797 |
Depressed mood | 56.80 | 10.33 | 187 | 125528 | 48293 | 79570380 |
Feeling of body temperature change | 56.78 | 10.33 | 55 | 125660 | 5271 | 79613402 |
Wound | 56.26 | 10.33 | 60 | 125655 | 116119 | 79502554 |
Folliculitis | 55.66 | 10.33 | 10 | 125705 | 55370 | 79563303 |
Loss of consciousness | 55.20 | 10.33 | 453 | 125262 | 167490 | 79451183 |
Menstrual disorder | 55.05 | 10.33 | 48 | 125667 | 4019 | 79614654 |
Hallucination, visual | 54.40 | 10.33 | 143 | 125572 | 32586 | 79586087 |
Sexual dysfunction | 54.13 | 10.33 | 64 | 125651 | 7699 | 79610974 |
Nasopharyngitis | 53.66 | 10.33 | 212 | 125503 | 253669 | 79365004 |
Dyspnoea | 53.45 | 10.33 | 991 | 124724 | 856034 | 78762639 |
Paraesthesia | 52.36 | 10.33 | 465 | 125250 | 175858 | 79442815 |
Congenital hydrocephalus | 51.72 | 10.33 | 14 | 125701 | 68 | 79618605 |
Abnormal dreams | 51.51 | 10.33 | 76 | 125639 | 11336 | 79607337 |
Paranoia | 51.35 | 10.33 | 102 | 125613 | 19330 | 79599343 |
Discomfort | 51.25 | 10.33 | 74 | 125641 | 125543 | 79493130 |
Therapeutic product ineffective | 51.24 | 10.33 | 34 | 125681 | 1888 | 79616785 |
Hypomania | 50.63 | 10.33 | 61 | 125654 | 7483 | 79611190 |
Breath sounds abnormal | 49.79 | 10.33 | 90 | 125625 | 15894 | 79602779 |
Bronchial haemorrhage | 49.48 | 10.33 | 29 | 125686 | 1291 | 79617382 |
Psoriatic arthropathy | 49.28 | 10.33 | 31 | 125684 | 77968 | 79540705 |
Arthropathy | 49.16 | 10.33 | 131 | 125584 | 176980 | 79441693 |
Restless legs syndrome | 48.98 | 10.33 | 102 | 125613 | 19990 | 79598683 |
Myelosuppression | 48.48 | 10.33 | 4 | 125711 | 40292 | 79578381 |
Hepatocellular injury | 48.28 | 10.33 | 175 | 125540 | 47418 | 79571255 |
Therapeutic product effect decreased | 47.95 | 10.33 | 118 | 125597 | 163745 | 79454928 |
Lower respiratory tract infection | 47.15 | 10.33 | 82 | 125633 | 129138 | 79489535 |
Cytomegalovirus infection | 46.74 | 10.33 | 6 | 125709 | 42638 | 79576035 |
Infection | 46.65 | 10.33 | 209 | 125506 | 241503 | 79377170 |
Hallucination | 46.62 | 10.33 | 262 | 125453 | 85483 | 79533190 |
Muscle disorder | 46.49 | 10.33 | 51 | 125664 | 5656 | 79613017 |
Muscle injury | 46.22 | 10.33 | 10 | 125705 | 48551 | 79570122 |
Thinking abnormal | 46.05 | 10.33 | 78 | 125637 | 13083 | 79605590 |
Mobility decreased | 45.99 | 10.33 | 76 | 125639 | 122099 | 79496574 |
Self esteem decreased | 45.62 | 10.33 | 25 | 125690 | 977 | 79617696 |
Apathy | 45.53 | 10.33 | 77 | 125638 | 12900 | 79605773 |
Cardio-respiratory arrest | 45.45 | 10.33 | 310 | 125405 | 108200 | 79510473 |
Galactorrhoea | 45.31 | 10.33 | 41 | 125674 | 3605 | 79615068 |
Seizure | 45.23 | 10.33 | 476 | 125239 | 188358 | 79430315 |
Asphyxia | 44.42 | 10.33 | 72 | 125643 | 11648 | 79607025 |
Bradykinesia | 44.40 | 10.33 | 59 | 125656 | 7984 | 79610689 |
Sleep disorder | 44.10 | 10.33 | 258 | 125457 | 85419 | 79533254 |
Neutrophil count decreased | 43.86 | 10.33 | 50 | 125665 | 93909 | 79524764 |
Hyperprolactinaemia | 43.78 | 10.33 | 45 | 125670 | 4631 | 79614042 |
Erectile dysfunction | 43.69 | 10.33 | 81 | 125634 | 14583 | 79604090 |
Pyrexia | 43.44 | 10.33 | 781 | 124934 | 677928 | 78940745 |
Pain | 43.14 | 10.33 | 816 | 124899 | 702986 | 78915687 |
Logorrhoea | 42.68 | 10.33 | 43 | 125672 | 4322 | 79614351 |
Renal ischaemia | 42.17 | 10.33 | 25 | 125690 | 1137 | 79617536 |
Neutropenia | 42.10 | 10.33 | 273 | 125442 | 287437 | 79331236 |
Blepharospasm | 42.06 | 10.33 | 49 | 125666 | 5802 | 79612871 |
Gun shot wound | 42.01 | 10.33 | 25 | 125690 | 1145 | 79617528 |
Anaemia | 41.91 | 10.33 | 474 | 125241 | 444541 | 79174132 |
Personality disorder | 41.75 | 10.33 | 50 | 125665 | 6096 | 79612577 |
Bipolar disorder | 41.73 | 10.33 | 56 | 125659 | 7651 | 79611022 |
Euphoric mood | 41.62 | 10.33 | 56 | 125659 | 7670 | 79611003 |
Visceral congestion | 41.19 | 10.33 | 23 | 125692 | 933 | 79617740 |
Hostility | 41.19 | 10.33 | 32 | 125683 | 2278 | 79616395 |
Death | 41.10 | 10.33 | 637 | 125078 | 565877 | 79052796 |
Muscle twitching | 40.95 | 10.33 | 108 | 125607 | 24656 | 79594017 |
PCO2 increased | 40.67 | 10.33 | 29 | 125686 | 1811 | 79616862 |
Substance abuse | 40.35 | 10.33 | 65 | 125650 | 10461 | 79608212 |
Hyperacusis | 40.09 | 10.33 | 31 | 125684 | 2192 | 79616481 |
Fear | 39.58 | 10.33 | 99 | 125616 | 21887 | 79596786 |
Parosmia | 39.57 | 10.33 | 52 | 125663 | 6962 | 79611711 |
Drug abuser | 39.35 | 10.33 | 48 | 125667 | 5965 | 79612708 |
Hangover | 39.28 | 10.33 | 30 | 125685 | 2082 | 79616591 |
Apraxia | 39.13 | 10.33 | 34 | 125681 | 2833 | 79615840 |
Chemical submission | 39.01 | 10.33 | 16 | 125699 | 321 | 79618352 |
Thrombocytopenia | 38.65 | 10.33 | 252 | 125463 | 265007 | 79353666 |
Tinnitus | 38.38 | 10.33 | 155 | 125560 | 44178 | 79574495 |
Pancytopenia | 37.87 | 10.33 | 134 | 125581 | 165611 | 79453062 |
Electrocardiogram QT prolonged | 37.71 | 10.33 | 258 | 125457 | 90128 | 79528545 |
Hyperthermia | 37.63 | 10.33 | 86 | 125629 | 17951 | 79600722 |
Arthralgia | 37.50 | 10.33 | 655 | 125060 | 571148 | 79047525 |
Amnesia | 37.19 | 10.33 | 197 | 125518 | 62860 | 79555813 |
Incontinence | 37.00 | 10.33 | 74 | 125641 | 14090 | 79604583 |
Neuropathy peripheral | 36.63 | 10.33 | 108 | 125607 | 141197 | 79477476 |
Ejaculation delayed | 36.59 | 10.33 | 13 | 125702 | 173 | 79618500 |
Rhabdomyolysis | 36.50 | 10.33 | 283 | 125432 | 102848 | 79515825 |
Rhonchi | 36.28 | 10.33 | 38 | 125677 | 3998 | 79614675 |
Amylase increased | 36.05 | 10.33 | 64 | 125651 | 11145 | 79607528 |
Psychomotor hyperactivity | 35.89 | 10.33 | 81 | 125634 | 16768 | 79601905 |
Affect lability | 35.84 | 10.33 | 64 | 125651 | 11195 | 79607478 |
Hypertonia | 35.32 | 10.33 | 50 | 125665 | 7182 | 79611491 |
Bronchial disorder | 34.95 | 10.33 | 30 | 125685 | 2459 | 79616214 |
Physical assault | 34.71 | 10.33 | 25 | 125690 | 1586 | 79617087 |
Verbal abuse | 34.55 | 10.33 | 14 | 125701 | 272 | 79618401 |
Premature labour | 33.80 | 10.33 | 53 | 125662 | 8337 | 79610336 |
Septic shock | 33.19 | 10.33 | 92 | 125623 | 122709 | 79495964 |
Tachycardia | 33.15 | 10.33 | 427 | 125288 | 177341 | 79441332 |
Loss of libido | 32.99 | 10.33 | 30 | 125685 | 2655 | 79616018 |
Endocrine ophthalmopathy | 32.70 | 10.33 | 18 | 125697 | 710 | 79617963 |
Mucosal inflammation | 32.35 | 10.33 | 43 | 125672 | 75537 | 79543136 |
Ascites | 31.32 | 10.33 | 44 | 125671 | 75518 | 79543155 |
Hypoaesthesia oral | 31.32 | 10.33 | 69 | 125646 | 14055 | 79604618 |
Respiratory acidosis | 31.06 | 10.33 | 60 | 125655 | 11140 | 79607533 |
Social anxiety disorder | 30.95 | 10.33 | 16 | 125699 | 555 | 79618118 |
Atrial fibrillation | 30.89 | 10.33 | 184 | 125531 | 197702 | 79420971 |
Anaphylactic reaction | 30.67 | 10.33 | 53 | 125662 | 83690 | 79534983 |
Increased appetite | 30.60 | 10.33 | 62 | 125653 | 11916 | 79606757 |
Product complaint | 30.49 | 10.33 | 66 | 125649 | 13283 | 79605390 |
Obsessive-compulsive disorder | 30.47 | 10.33 | 42 | 125673 | 5885 | 79612788 |
Sinus tachycardia | 30.34 | 10.33 | 127 | 125588 | 36781 | 79581892 |
Soft tissue injury | 30.31 | 10.33 | 24 | 125691 | 1757 | 79616916 |
Hepatotoxicity | 30.31 | 10.33 | 22 | 125693 | 51330 | 79567343 |
Dizziness | 30.00 | 10.33 | 1062 | 124653 | 525379 | 79093294 |
Generalised anxiety disorder | 29.88 | 10.33 | 26 | 125689 | 2171 | 79616502 |
Troponin increased | 29.85 | 10.33 | 82 | 125633 | 19173 | 79599500 |
Major depression | 29.82 | 10.33 | 52 | 125663 | 8928 | 79609745 |
Antidepressant discontinuation syndrome | 29.70 | 10.33 | 8 | 125707 | 38 | 79618635 |
Dependence | 29.63 | 10.33 | 27 | 125688 | 2395 | 79616278 |
Abdominal pain | 29.60 | 10.33 | 434 | 125281 | 389135 | 79229538 |
Sensory loss | 29.41 | 10.33 | 64 | 125651 | 12927 | 79605746 |
Dysarthria | 29.39 | 10.33 | 195 | 125520 | 67427 | 79551246 |
Joint hyperextension | 29.32 | 10.33 | 13 | 125702 | 318 | 79618355 |
Neutropenic sepsis | 29.20 | 10.33 | 4 | 125711 | 27060 | 79591613 |
Poisoning | 29.17 | 10.33 | 97 | 125618 | 25175 | 79593498 |
Hip arthroplasty | 29.08 | 10.33 | 10 | 125705 | 35746 | 79582927 |
Toxic encephalopathy | 28.97 | 10.33 | 59 | 125656 | 11381 | 79607292 |
Urinary retention | 28.79 | 10.33 | 170 | 125545 | 56460 | 79562213 |
Electroencephalogram abnormal | 28.68 | 10.33 | 39 | 125676 | 5395 | 79613278 |
Illusion | 28.64 | 10.33 | 23 | 125692 | 1718 | 79616955 |
Oral discharge | 28.58 | 10.33 | 12 | 125703 | 256 | 79618417 |
Head titubation | 28.47 | 10.33 | 18 | 125697 | 920 | 79617753 |
Gastrointestinal disorder | 28.45 | 10.33 | 98 | 125617 | 122107 | 79496566 |
Panic disorder | 28.39 | 10.33 | 29 | 125686 | 2963 | 79615710 |
PO2 increased | 28.32 | 10.33 | 22 | 125693 | 1566 | 79617107 |
Schizophrenia | 28.29 | 10.33 | 70 | 125645 | 15370 | 79603303 |
Anorgasmia | 28.26 | 10.33 | 20 | 125695 | 1234 | 79617439 |
Impaired healing | 28.16 | 10.33 | 60 | 125655 | 87595 | 79531078 |
Ejaculation failure | 28.11 | 10.33 | 13 | 125702 | 352 | 79618321 |
Irritable bowel syndrome | 28.10 | 10.33 | 34 | 125681 | 62207 | 79556466 |
Vulvovaginal burning sensation | 27.97 | 10.33 | 22 | 125693 | 1595 | 79617078 |
Chorea | 27.74 | 10.33 | 26 | 125689 | 2391 | 79616282 |
Mood altered | 27.67 | 10.33 | 76 | 125639 | 17771 | 79600902 |
Platelet count decreased | 27.31 | 10.33 | 187 | 125528 | 194477 | 79424196 |
Sensory disturbance | 27.25 | 10.33 | 68 | 125647 | 15009 | 79603664 |
Anticholinergic syndrome | 27.23 | 10.33 | 31 | 125684 | 3580 | 79615093 |
Balance disorder | 26.94 | 10.33 | 256 | 125459 | 98601 | 79520072 |
Coma scale | 26.84 | 10.33 | 8 | 125707 | 58 | 79618615 |
Rheumatoid factor positive | 26.69 | 10.33 | 33 | 125682 | 59806 | 79558867 |
Paralysis | 26.58 | 10.33 | 62 | 125653 | 13115 | 79605558 |
Diarrhoea | 26.53 | 10.33 | 1127 | 124588 | 879362 | 78739311 |
Negative thoughts | 26.30 | 10.33 | 20 | 125695 | 1379 | 79617294 |
Encephalopathy | 26.13 | 10.33 | 189 | 125526 | 67208 | 79551465 |
Cerebral microhaemorrhage | 26.10 | 10.33 | 11 | 125704 | 237 | 79618436 |
Weight increased | 25.94 | 10.33 | 596 | 125119 | 276790 | 79341883 |
Oedema | 25.79 | 10.33 | 99 | 125616 | 119481 | 79499192 |
Catatonia | 25.63 | 10.33 | 48 | 125667 | 8708 | 79609965 |
Obsessive thoughts | 25.39 | 10.33 | 18 | 125697 | 1114 | 79617559 |
Tension | 25.39 | 10.33 | 33 | 125682 | 4371 | 79614302 |
Cardiac failure | 25.22 | 10.33 | 142 | 125573 | 154700 | 79463973 |
Therapy non-responder | 25.05 | 10.33 | 69 | 125646 | 92236 | 79526437 |
Post-traumatic neck syndrome | 24.95 | 10.33 | 23 | 125692 | 2071 | 79616602 |
Vision blurred | 24.90 | 10.33 | 266 | 125449 | 105632 | 79513041 |
Eye movement disorder | 24.81 | 10.33 | 45 | 125670 | 7966 | 79610707 |
Metastases to liver | 24.67 | 10.33 | 7 | 125708 | 28307 | 79590366 |
Alcohol abuse | 24.62 | 10.33 | 36 | 125679 | 5327 | 79613346 |
Hypokinesia | 24.58 | 10.33 | 76 | 125639 | 18984 | 79599689 |
Social avoidant behaviour | 24.58 | 10.33 | 34 | 125681 | 4780 | 79613893 |
Epilepsy | 24.33 | 10.33 | 128 | 125587 | 40732 | 79577941 |
Product dose omission issue | 24.32 | 10.33 | 261 | 125454 | 247276 | 79371397 |
Joint range of motion decreased | 24.29 | 10.33 | 11 | 125704 | 33271 | 79585402 |
Creutzfeldt-Jakob disease | 24.18 | 10.33 | 10 | 125705 | 205 | 79618468 |
Injection site erythema | 23.90 | 10.33 | 55 | 125660 | 78142 | 79540531 |
Toxic shock syndrome | 23.80 | 10.33 | 18 | 125697 | 1231 | 79617442 |
Multiple organ dysfunction syndrome | 23.76 | 10.33 | 103 | 125612 | 120143 | 79498530 |
Depressive symptom | 23.72 | 10.33 | 39 | 125676 | 6384 | 79612289 |
Incoherent | 23.56 | 10.33 | 43 | 125672 | 7649 | 79611024 |
Treatment noncompliance | 23.49 | 10.33 | 152 | 125563 | 52116 | 79566557 |
Pneumocystis jirovecii pneumonia | 23.33 | 10.33 | 11 | 125704 | 32497 | 79586176 |
Accidental poisoning | 23.32 | 10.33 | 20 | 125695 | 1637 | 79617036 |
Fibromyalgia | 23.31 | 10.33 | 41 | 125674 | 64299 | 79554374 |
Urticaria thermal | 22.78 | 10.33 | 12 | 125703 | 433 | 79618240 |
Prostate cancer | 22.75 | 10.33 | 12 | 125703 | 33256 | 79585417 |
Pain in extremity | 22.46 | 10.33 | 422 | 125293 | 364116 | 79254557 |
Diabetes insipidus | 22.38 | 10.33 | 34 | 125681 | 5203 | 79613470 |
Feeling guilty | 22.29 | 10.33 | 15 | 125700 | 853 | 79617820 |
Blood pH decreased | 22.17 | 10.33 | 32 | 125683 | 4679 | 79613994 |
White blood cell count decreased | 22.11 | 10.33 | 190 | 125525 | 188098 | 79430575 |
Cognitive disorder | 22.09 | 10.33 | 187 | 125528 | 69739 | 79548934 |
Housebound | 22.02 | 10.33 | 12 | 125703 | 464 | 79618209 |
Trichotillomania | 21.93 | 10.33 | 9 | 125706 | 181 | 79618492 |
Thermal burn | 21.90 | 10.33 | 40 | 125675 | 7120 | 79611553 |
Product use in unapproved indication | 21.86 | 10.33 | 271 | 125444 | 250088 | 79368585 |
Idiosyncratic alcohol intoxication | 21.82 | 10.33 | 4 | 125711 | 0 | 79618673 |
Acute kidney injury | 21.76 | 10.33 | 638 | 125077 | 518766 | 79099907 |
Frontotemporal dementia | 21.72 | 10.33 | 13 | 125702 | 602 | 79618071 |
Tardive dyskinesia | 21.61 | 10.33 | 50 | 125665 | 10521 | 79608152 |
Oxygen saturation abnormal | 21.38 | 10.33 | 31 | 125684 | 4551 | 79614122 |
Knee arthroplasty | 21.30 | 10.33 | 22 | 125693 | 43226 | 79575447 |
Blood sodium decreased | 21.07 | 10.33 | 106 | 125609 | 33149 | 79585524 |
Judgement impaired | 21.02 | 10.33 | 17 | 125698 | 1283 | 79617390 |
Pneumonitis | 20.96 | 10.33 | 40 | 125675 | 60820 | 79557853 |
Maternal exposure during pregnancy | 20.75 | 10.33 | 128 | 125587 | 136410 | 79482263 |
Clostridium difficile infection | 20.70 | 10.33 | 22 | 125693 | 42663 | 79576010 |
Mental disorder | 20.70 | 10.33 | 101 | 125614 | 31201 | 79587472 |
Injection site pain | 20.64 | 10.33 | 120 | 125595 | 129718 | 79488955 |
Self-injurious ideation | 20.57 | 10.33 | 27 | 125688 | 3611 | 79615062 |
Feelings of worthlessness | 20.36 | 10.33 | 12 | 125703 | 540 | 79618133 |
Aspergillus infection | 20.28 | 10.33 | 3 | 125712 | 19158 | 79599515 |
Posterior reversible encephalopathy syndrome | 20.28 | 10.33 | 8 | 125707 | 26273 | 79592400 |
Blood lactate dehydrogenase increased | 20.18 | 10.33 | 118 | 125597 | 39052 | 79579621 |
Alcoholism | 20.08 | 10.33 | 27 | 125688 | 3696 | 79614977 |
Psychiatric symptom | 19.89 | 10.33 | 38 | 125677 | 6997 | 79611676 |
Inadequate analgesia | 19.71 | 10.33 | 30 | 125685 | 4599 | 79614074 |
Sternal fracture | 19.56 | 10.33 | 22 | 125693 | 2508 | 79616165 |
Skin laceration | 19.55 | 10.33 | 94 | 125621 | 28868 | 79589805 |
Accommodation disorder | 19.47 | 10.33 | 12 | 125703 | 586 | 79618087 |
Bradycardia | 19.43 | 10.33 | 311 | 125404 | 135246 | 79483427 |
Cytokine release syndrome | 19.26 | 10.33 | 17 | 125698 | 35981 | 79582692 |
Disinhibition | 19.08 | 10.33 | 22 | 125693 | 2576 | 79616097 |
Rhinitis | 19.06 | 10.33 | 59 | 125656 | 14748 | 79603925 |
Rhinalgia | 19.02 | 10.33 | 21 | 125694 | 2346 | 79616327 |
Administration site erythema | 18.98 | 10.33 | 10 | 125705 | 361 | 79618312 |
Leukopenia | 18.88 | 10.33 | 107 | 125608 | 116406 | 79502267 |
Cellulitis | 18.86 | 10.33 | 98 | 125617 | 108962 | 79509711 |
Sinusitis | 18.85 | 10.33 | 207 | 125508 | 195294 | 79423379 |
Musculoskeletal pain | 18.84 | 10.33 | 90 | 125625 | 102264 | 79516409 |
Drug screen positive | 18.71 | 10.33 | 34 | 125681 | 6029 | 79612644 |
Somatic dysfunction | 18.69 | 10.33 | 5 | 125710 | 23 | 79618650 |
Cyanosis | 18.66 | 10.33 | 84 | 125631 | 25098 | 79593575 |
Neoplasm progression | 18.66 | 10.33 | 33 | 125682 | 51649 | 79567024 |
Hyperlipidaemia | 18.57 | 10.33 | 86 | 125629 | 26007 | 79592666 |
Haemoglobin decreased | 18.43 | 10.33 | 243 | 125472 | 221876 | 79396797 |
Feeling abnormal | 18.43 | 10.33 | 353 | 125362 | 158846 | 79459827 |
Colitis | 18.29 | 10.33 | 57 | 125658 | 73250 | 79545423 |
Dissociative disorder | 18.29 | 10.33 | 13 | 125702 | 808 | 79617865 |
Ejaculation disorder | 18.02 | 10.33 | 11 | 125704 | 528 | 79618145 |
Respiratory tract infection | 17.66 | 10.33 | 31 | 125684 | 48658 | 79570015 |
Mental impairment | 17.64 | 10.33 | 68 | 125647 | 18968 | 79599705 |
Hyperarousal | 17.59 | 10.33 | 5 | 125710 | 30 | 79618643 |
Brugada syndrome | 17.54 | 10.33 | 15 | 125700 | 1223 | 79617450 |
Foetal death | 17.50 | 10.33 | 39 | 125676 | 8005 | 79610668 |
Poriomania | 17.39 | 10.33 | 8 | 125707 | 214 | 79618459 |
Parkinson's disease | 17.33 | 10.33 | 17 | 125698 | 1654 | 79617019 |
Palmar-plantar erythrodysaesthesia syndrome | 17.31 | 10.33 | 16 | 125699 | 33118 | 79585555 |
Renal impairment | 17.30 | 10.33 | 162 | 125553 | 157621 | 79461052 |
Myoglobin blood increased | 17.22 | 10.33 | 23 | 125692 | 3128 | 79615545 |
Muscle tightness | 17.13 | 10.33 | 52 | 125663 | 12862 | 79605811 |
Middle insomnia | 17.07 | 10.33 | 60 | 125655 | 16009 | 79602664 |
Campylobacter colitis | 17.05 | 10.33 | 5 | 125710 | 34 | 79618639 |
Bronchopulmonary aspergillosis | 16.85 | 10.33 | 7 | 125708 | 22287 | 79596386 |
Plasmodium vivax infection | 16.82 | 10.33 | 4 | 125711 | 10 | 79618663 |
Resting tremor | 16.77 | 10.33 | 16 | 125699 | 1505 | 79617168 |
Sluggishness | 16.77 | 10.33 | 34 | 125681 | 6538 | 79612135 |
Eyelid disorder | 16.68 | 10.33 | 18 | 125697 | 1960 | 79616713 |
Hyperkinesia | 16.60 | 10.33 | 21 | 125694 | 2708 | 79615965 |
Therapy interrupted | 16.53 | 10.33 | 15 | 125700 | 31326 | 79587347 |
Localised infection | 16.47 | 10.33 | 21 | 125694 | 37554 | 79581119 |
Dysacusis | 16.36 | 10.33 | 3 | 125712 | 0 | 79618673 |
Toxicologic test abnormal | 16.33 | 10.33 | 15 | 125700 | 1345 | 79617328 |
Grip strength decreased | 16.32 | 10.33 | 7 | 125708 | 21862 | 79596811 |
Haemophagocytic lymphohistiocytosis | 16.28 | 10.33 | 7 | 125708 | 21830 | 79596843 |
Reversible cerebral vasoconstriction syndrome | 16.23 | 10.33 | 22 | 125693 | 3035 | 79615638 |
Oedema peripheral | 16.17 | 10.33 | 290 | 125425 | 251998 | 79366675 |
Drug resistance | 16.12 | 10.33 | 26 | 125689 | 42187 | 79576486 |
Hospitalisation | 16.12 | 10.33 | 85 | 125630 | 94151 | 79524522 |
Tri-iodothyronine free decreased | 15.99 | 10.33 | 9 | 125706 | 371 | 79618302 |
Phonophobia | 15.90 | 10.33 | 10 | 125705 | 506 | 79618167 |
Lactose intolerance | 15.90 | 10.33 | 19 | 125696 | 2311 | 79616362 |
Clumsiness | 15.84 | 10.33 | 22 | 125693 | 3105 | 79615568 |
Vasculitis | 15.82 | 10.33 | 10 | 125705 | 25092 | 79593581 |
Generalised tonic-clonic seizure | 15.81 | 10.33 | 121 | 125594 | 43789 | 79574884 |
Persecutory delusion | 15.75 | 10.33 | 28 | 125687 | 4881 | 79613792 |
Soliloquy | 15.68 | 10.33 | 11 | 125704 | 669 | 79618004 |
Altered visual depth perception | 15.62 | 10.33 | 9 | 125706 | 388 | 79618285 |
Vulvovaginal pruritus | 15.60 | 10.33 | 20 | 125695 | 2613 | 79616060 |
Fluid retention | 15.56 | 10.33 | 57 | 125658 | 69752 | 79548921 |
C-reactive protein increased | 15.23 | 10.33 | 130 | 125585 | 128897 | 79489776 |
Epistaxis | 15.20 | 10.33 | 108 | 125607 | 111407 | 79507266 |
Fatigue | 15.18 | 10.33 | 1261 | 124454 | 928466 | 78690207 |
Spinal pain | 15.00 | 10.33 | 3 | 125712 | 15389 | 79603284 |
Migraine | 14.99 | 10.33 | 207 | 125508 | 87286 | 79531387 |
Bladder cancer | 14.97 | 10.33 | 6 | 125709 | 19520 | 79599153 |
Sedation | 14.94 | 10.33 | 136 | 125579 | 51759 | 79566914 |
Hypersomnia | 14.91 | 10.33 | 74 | 125641 | 23012 | 79595661 |
Blood chloride decreased | 14.91 | 10.33 | 37 | 125678 | 8140 | 79610533 |
Intentional device use issue | 14.85 | 10.33 | 5 | 125710 | 56 | 79618617 |
Dissociative amnesia | 14.83 | 10.33 | 6 | 125709 | 116 | 79618557 |
Poor quality sleep | 14.80 | 10.33 | 73 | 125642 | 22649 | 79596024 |
Amimia | 14.77 | 10.33 | 5 | 125710 | 57 | 79618616 |
Pleural effusion | 14.73 | 10.33 | 152 | 125563 | 145110 | 79473563 |
Vasoplegia syndrome | 14.72 | 10.33 | 23 | 125692 | 3607 | 79615066 |
Subdural haematoma | 14.48 | 10.33 | 92 | 125623 | 31342 | 79587331 |
Tumour lysis syndrome | 14.46 | 10.33 | 10 | 125705 | 23929 | 79594744 |
Vascular stenosis | 14.44 | 10.33 | 10 | 125705 | 596 | 79618077 |
Antiphospholipid antibodies | 14.42 | 10.33 | 6 | 125709 | 125 | 79618548 |
Cystocele | 14.38 | 10.33 | 11 | 125704 | 765 | 79617908 |
Mental status changes | 14.27 | 10.33 | 165 | 125550 | 66794 | 79551879 |
Marital problem | 14.26 | 10.33 | 7 | 125708 | 217 | 79618456 |
Diabetic hyperosmolar coma | 14.12 | 10.33 | 11 | 125704 | 786 | 79617887 |
Respiratory depression | 14.08 | 10.33 | 83 | 125632 | 27547 | 79591126 |
Impatience | 14.06 | 10.33 | 10 | 125705 | 622 | 79618051 |
Hypoosmolar state | 14.01 | 10.33 | 8 | 125707 | 339 | 79618334 |
Dizziness postural | 13.93 | 10.33 | 45 | 125670 | 11504 | 79607169 |
Hypervolaemia | 13.89 | 10.33 | 29 | 125686 | 42661 | 79576012 |
Nasal ulcer | 13.87 | 10.33 | 17 | 125698 | 2123 | 79616550 |
Suspiciousness | 13.85 | 10.33 | 10 | 125705 | 637 | 79618036 |
Compartment syndrome | 13.82 | 10.33 | 27 | 125688 | 5055 | 79613618 |
Chronic spontaneous urticaria | 13.73 | 10.33 | 13 | 125702 | 1211 | 79617462 |
Bacteraemia | 13.71 | 10.33 | 19 | 125696 | 32805 | 79585868 |
Infusion site scar | 13.67 | 10.33 | 8 | 125707 | 355 | 79618318 |
Influenza like illness | 13.67 | 10.33 | 173 | 125542 | 71534 | 79547139 |
Hyperventilation | 13.62 | 10.33 | 35 | 125680 | 7864 | 79610809 |
Trismus | 13.61 | 10.33 | 28 | 125687 | 5439 | 79613234 |
Plasma cell myeloma | 13.58 | 10.33 | 41 | 125674 | 53218 | 79565455 |
Wrong patient | 13.57 | 10.33 | 8 | 125707 | 360 | 79618313 |
Wheezing | 13.57 | 10.33 | 118 | 125597 | 116546 | 79502127 |
Gaze palsy | 13.54 | 10.33 | 20 | 125695 | 2985 | 79615688 |
Cerebral haematoma | 13.50 | 10.33 | 35 | 125680 | 7907 | 79610766 |
Stupor | 13.49 | 10.33 | 32 | 125683 | 6840 | 79611833 |
Chronic kidney disease | 13.48 | 10.33 | 56 | 125659 | 66098 | 79552575 |
Sleep disorder due to a general medical condition | 13.46 | 10.33 | 3 | 125712 | 14274 | 79604399 |
Decreased activity | 13.45 | 10.33 | 37 | 125678 | 8657 | 79610016 |
Blood bicarbonate decreased | 13.42 | 10.33 | 27 | 125688 | 5164 | 79613509 |
Coronary artery disease | 13.36 | 10.33 | 160 | 125555 | 65314 | 79553359 |
Immunodeficiency | 13.27 | 10.33 | 9 | 125706 | 21759 | 79596914 |
Diet refusal | 13.26 | 10.33 | 11 | 125704 | 860 | 79617813 |
Cholecystitis chronic | 13.24 | 10.33 | 40 | 125675 | 9866 | 79608807 |
Dermatitis allergic | 13.22 | 10.33 | 6 | 125709 | 18124 | 79600549 |
Accidental death | 13.16 | 10.33 | 24 | 125691 | 4267 | 79614406 |
Cerebrovascular stenosis | 13.13 | 10.33 | 6 | 125709 | 158 | 79618515 |
Dairy intolerance | 13.12 | 10.33 | 5 | 125710 | 82 | 79618591 |
Upper respiratory tract infection | 13.06 | 10.33 | 87 | 125628 | 91081 | 79527592 |
Nephropathy toxic | 13.06 | 10.33 | 8 | 125707 | 20411 | 79598262 |
Perseveration | 13.01 | 10.33 | 8 | 125707 | 389 | 79618284 |
Laboratory test abnormal | 13.00 | 10.33 | 15 | 125700 | 28033 | 79590640 |
Thought insertion | 12.87 | 10.33 | 4 | 125711 | 34 | 79618639 |
Productive cough | 12.81 | 10.33 | 84 | 125631 | 88247 | 79530426 |
Urticaria | 12.79 | 10.33 | 210 | 125505 | 184991 | 79433682 |
Violence-related symptom | 12.76 | 10.33 | 10 | 125705 | 721 | 79617952 |
Injection site pruritus | 12.71 | 10.33 | 30 | 125685 | 42253 | 79576420 |
Slow response to stimuli | 12.65 | 10.33 | 15 | 125700 | 1810 | 79616863 |
Delivery | 12.63 | 10.33 | 10 | 125705 | 732 | 79617941 |
Blood triglycerides increased | 12.58 | 10.33 | 66 | 125649 | 20974 | 79597699 |
Intention tremor | 12.58 | 10.33 | 10 | 125705 | 736 | 79617937 |
Arthritis | 12.57 | 10.33 | 118 | 125597 | 114762 | 79503911 |
Granuloma | 12.53 | 10.33 | 35 | 125680 | 8262 | 79610411 |
Neurotoxicity | 12.44 | 10.33 | 20 | 125695 | 32498 | 79586175 |
Posture abnormal | 12.34 | 10.33 | 22 | 125693 | 3844 | 79614829 |
Hypoaesthesia | 12.29 | 10.33 | 370 | 125345 | 178982 | 79439691 |
Device related infection | 12.29 | 10.33 | 22 | 125693 | 34272 | 79584401 |
Aphasia | 12.23 | 10.33 | 120 | 125595 | 46612 | 79572061 |
Product administration error | 12.17 | 10.33 | 89 | 125626 | 31757 | 79586916 |
Colitis microscopic | 12.13 | 10.33 | 41 | 125674 | 10727 | 79607946 |
Ankle fracture | 12.13 | 10.33 | 56 | 125659 | 16913 | 79601760 |
Dyssomnia | 12.11 | 10.33 | 4 | 125711 | 42 | 79618631 |
Erythema | 12.09 | 10.33 | 264 | 125451 | 223026 | 79395647 |
Ammonia abnormal | 12.05 | 10.33 | 6 | 125709 | 192 | 79618481 |
Anhedonia | 12.04 | 10.33 | 51 | 125664 | 14847 | 79603826 |
Antipsychotic drug level increased | 11.98 | 10.33 | 28 | 125687 | 5929 | 79612744 |
Bone marrow failure | 11.88 | 10.33 | 41 | 125674 | 51066 | 79567607 |
Head injury | 11.83 | 10.33 | 100 | 125615 | 37269 | 79581404 |
Tonic convulsion | 11.82 | 10.33 | 16 | 125699 | 2204 | 79616469 |
Blood aldosterone abnormal | 11.79 | 10.33 | 4 | 125711 | 46 | 79618627 |
Metastases to lung | 11.78 | 10.33 | 7 | 125708 | 18156 | 79600517 |
Oscillopsia | 11.77 | 10.33 | 6 | 125709 | 202 | 79618471 |
Serum sickness-like reaction | 11.77 | 10.33 | 9 | 125706 | 626 | 79618047 |
Impaired quality of life | 11.74 | 10.33 | 4 | 125711 | 14382 | 79604291 |
Jealous delusion | 11.72 | 10.33 | 7 | 125708 | 323 | 79618350 |
Exhibitionism | 11.71 | 10.33 | 4 | 125711 | 47 | 79618626 |
Enterococcal infection | 11.71 | 10.33 | 5 | 125710 | 15655 | 79603018 |
Cytopenia | 11.68 | 10.33 | 9 | 125706 | 20374 | 79598299 |
Sinus congestion | 11.62 | 10.33 | 62 | 125653 | 19834 | 79598839 |
Tenosynovitis | 11.57 | 10.33 | 5 | 125710 | 15549 | 79603124 |
Ear infection | 11.54 | 10.33 | 23 | 125692 | 34409 | 79584264 |
Cyclothymic disorder | 11.50 | 10.33 | 6 | 125709 | 212 | 79618461 |
Hyperbilirubinaemia | 11.49 | 10.33 | 13 | 125702 | 24505 | 79594168 |
Paroxysmal arrhythmia | 11.49 | 10.33 | 4 | 125711 | 50 | 79618623 |
Liver injury | 11.49 | 10.33 | 48 | 125667 | 56566 | 79562107 |
Thrombotic microangiopathy | 11.44 | 10.33 | 9 | 125706 | 20160 | 79598513 |
Scratch | 11.40 | 10.33 | 34 | 125681 | 8329 | 79610344 |
Impulse-control disorder | 11.35 | 10.33 | 14 | 125701 | 1760 | 79616913 |
Liver function test increased | 11.34 | 10.33 | 29 | 125686 | 39744 | 79578929 |
Hypervigilance | 11.34 | 10.33 | 8 | 125707 | 491 | 79618182 |
Fibrocystic breast disease | 11.34 | 10.33 | 9 | 125706 | 661 | 79618012 |
Oropharyngeal pain | 11.26 | 10.33 | 114 | 125601 | 109239 | 79509434 |
Suicidal behaviour | 11.04 | 10.33 | 19 | 125696 | 3228 | 79615445 |
Vascular access site pain | 11.00 | 10.33 | 5 | 125710 | 130 | 79618543 |
Psychomotor skills impaired | 10.96 | 10.33 | 25 | 125690 | 5212 | 79613461 |
Hypercholesterolaemia | 10.89 | 10.33 | 68 | 125647 | 23027 | 79595646 |
Energy increased | 10.89 | 10.33 | 19 | 125696 | 3263 | 79615410 |
Haemodynamic instability | 10.85 | 10.33 | 7 | 125708 | 17375 | 79601298 |
Normetanephrine urine increased | 10.85 | 10.33 | 3 | 125712 | 16 | 79618657 |
Rash macular | 10.85 | 10.33 | 18 | 125697 | 28881 | 79589792 |
Injection site swelling | 10.83 | 10.33 | 38 | 125677 | 47094 | 79571579 |
Inflammation | 10.82 | 10.33 | 95 | 125620 | 93658 | 79525015 |
Delusional perception | 10.81 | 10.33 | 7 | 125708 | 373 | 79618300 |
Yawning | 10.77 | 10.33 | 12 | 125703 | 1354 | 79617319 |
Antisocial behaviour | 10.76 | 10.33 | 9 | 125706 | 712 | 79617961 |
Cardiotoxicity | 10.71 | 10.33 | 3 | 125712 | 12236 | 79606437 |
Back pain | 10.71 | 10.33 | 382 | 125333 | 303798 | 79314875 |
Prescription form tampering | 10.61 | 10.33 | 7 | 125708 | 385 | 79618288 |
Autoimmune nephritis | 10.57 | 10.33 | 9 | 125706 | 730 | 79617943 |
Rash erythematous | 10.51 | 10.33 | 51 | 125664 | 57718 | 79560955 |
Decreased interest | 10.49 | 10.33 | 20 | 125695 | 3677 | 79614996 |
Imprisonment | 10.48 | 10.33 | 8 | 125707 | 555 | 79618118 |
Anaphylactic shock | 10.46 | 10.33 | 26 | 125689 | 35970 | 79582703 |
Herpes zoster | 10.45 | 10.33 | 95 | 125620 | 92988 | 79525685 |
Feeling of relaxation | 10.43 | 10.33 | 5 | 125710 | 147 | 79618526 |
Transaminases increased | 10.42 | 10.33 | 44 | 125671 | 51699 | 79566974 |
Hyper IgE syndrome | 10.38 | 10.33 | 8 | 125707 | 563 | 79618110 |
Gastrointestinal haemorrhage | 10.36 | 10.33 | 167 | 125548 | 147552 | 79471121 |
Metastases to bone | 10.35 | 10.33 | 14 | 125701 | 24413 | 79594260 |
None
Source | Code | Description |
---|---|---|
ATC | N06AB05 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Selective serotonin reuptake inhibitors |
FDA MoA | N0000000109 | Serotonin Uptake Inhibitors |
CHEBI has role | CHEBI:35469 | antidepressants |
CHEBI has role | CHEBI:35474 | anti-anxiety agents |
CHEBI has role | CHEBI:50183 | P450 inhibitors |
CHEBI has role | CHEBI:50908 | agente hepatotoxico |
CHEBI has role | CHEBI:50949 | SSRI |
FDA EPC | N0000175696 | Serotonin Reuptake Inhibitor |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D018687 | Antidepressive Agents, Second-Generation |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D065690 | Cytochrome P-450 CYP2D6 Inhibitors |
MeSH PA | D065607 | Cytochrome P-450 Enzyme Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D065606 | Metabolic Side Effects of Drugs and Substances |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D017367 | Selective Serotonin Reuptake Inhibitors |
MeSH PA | D018490 | Serotonin Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Premenstrual dysphoric disorder | indication | 596004 | |
Generalized anxiety disorder | indication | 21897009 | DOID:14320 |
Social phobia | indication | 25501002 | DOID:11257 |
Depressive disorder | indication | 35489007 | |
Posttraumatic stress disorder | indication | 47505003 | DOID:2055 |
Obsessive-compulsive disorder | indication | 191736004 | DOID:10933 |
Menopausal flushing | indication | 198436008 | |
Major depressive disorder | indication | 370143000 | |
Panic disorder | indication | 371631005 | DOID:594 |
Bipolar affective disorder, current episode depression | off-label use | 191627008 | DOID:3312 |
Fibromyalgia | off-label use | 203082005 | DOID:631 |
Suicidal thoughts | contraindication | 6471006 | |
Bipolar disorder | contraindication | 13746004 | DOID:3312 |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Upper gastrointestinal hemorrhage | contraindication | 37372002 | |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Acute nephropathy | contraindication | 58574008 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Hyponatremia | contraindication | 89627008 | |
Seizure disorder | contraindication | 128613002 | |
Mania | contraindication | 231494001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Pathological fracture | contraindication | 268029009 | |
Akathisia | contraindication | 285145004 | |
Pregnancy, function | contraindication | 289908002 | |
Serotonin syndrome | contraindication | 371089000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.51 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
EQ 7.5MG BASE | BRISDELLE | SEBELA IRELAND LTD | N204516 | June 28, 2013 | RX | CAPSULE | ORAL | 8946251 | Aug. 4, 2026 | TREATMENT OF MODERATE TO SEVERE VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE |
EQ 7.5MG BASE | BRISDELLE | SEBELA IRELAND LTD | N204516 | June 28, 2013 | RX | CAPSULE | ORAL | 9393237 | Aug. 4, 2026 | TREATMENT OF MODERATE TO SEVERE VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE |
EQ 7.5MG BASE | BRISDELLE | SEBELA IRELAND LTD | N204516 | June 28, 2013 | RX | CAPSULE | ORAL | 8658663 | April 6, 2029 | TREATMENT OF MODERATE TO SEVERE VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Ki | 10.40 | CHEMBL | CHEMBL | |||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 5.65 | DRUG MATRIX | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | Ki | 5.07 | DRUG MATRIX | |||||
Sodium-dependent noradrenaline transporter | Transporter | Kd | 7.40 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 1A | GPCR | Kd | 4.52 | CHEMBL | |||||
D(3) dopamine receptor | GPCR | Ki | 5.42 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 7.46 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M2 | GPCR | Ki | 6.72 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M3 | GPCR | Ki | 7.42 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M4 | GPCR | Ki | 7.47 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M5 | GPCR | Ki | 7.05 | DRUG MATRIX | |||||
Sodium-dependent dopamine transporter | Transporter | Kd | 6.31 | WOMBAT-PK | |||||
Cytochrome P450 2D6 | Enzyme | IC50 | 6 | DRUG MATRIX | |||||
Cytochrome P450 1A2 | Enzyme | IC50 | 4.96 | WOMBAT-PK | |||||
Substance-P receptor | GPCR | IC50 | 6.05 | CHEMBL | |||||
Potassium voltage-gated channel subfamily A member 3 | Ion channel | IC50 | 4.50 | CHEMBL | |||||
Myeloperoxidase | Enzyme | IC50 | 7.70 | CHEMBL | |||||
Beta-adrenergic receptor kinase 1 | Kinase | IC50 | 5.86 | CHEMBL | |||||
P2X purinoceptor 4 | Ion channel | IC50 | 5.33 | CHEMBL | |||||
Beta-1 adrenergic receptor | GPCR | Ki | 5 | WOMBAT-PK | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 10.30 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 7.01 | CHEMBL | |||||
Transporter | Transporter | Ki | 7.48 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 9.36 | CHEMBL | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 7.70 | CHEMBL | |||||
Transporter | Transporter | Ki | 7.23 | CHEMBL | |||||
Quinolone resistance protein NorA | Transporter | IC50 | 5.15 | CHEMBL | |||||
Adrenergic receptor alpha-2 | GPCR | Ki | 5.20 | CHEMBL | |||||
Adrenergic receptor alpha-1 | GPCR | Ki | 5.27 | CHEMBL | |||||
P2X purinoceptor 4 | Ion channel | IC50 | 5.61 | CHEMBL | |||||
Beta-adrenergic receptor kinase 1 | Kinase | IC50 | 5.89 | CHEMBL |
ID | Source |
---|---|
D02260 | KEGG_DRUG |
110429-35-1 | SECONDARY_CAS_RN |
217797-14-3 | SECONDARY_CAS_RN |
78246-49-8 | SECONDARY_CAS_RN |
4020738 | VANDF |
4020815 | VANDF |
C0070122 | UMLSCUI |
CHEBI:7936 | CHEBI |
8PR | PDB_CHEM_ID |
CHEMBL490 | ChEMBL_ID |
CHEMBL4297919 | ChEMBL_ID |
CHEMBL1200609 | ChEMBL_ID |
DB00715 | DRUGBANK_ID |
CHEMBL1708 | ChEMBL_ID |
CHEMBL1256912 | ChEMBL_ID |
D017374 | MESH_DESCRIPTOR_UI |
43815 | PUBCHEM_CID |
4790 | IUPHAR_LIGAND_ID |
4327 | INN_ID |
41VRH5220H | UNII |
114228 | RXNORM |
18339 | MMSL |
205288 | MMSL |
262886 | MMSL |
29631 | MMSL |
4517 | MMSL |
47422 | MMSL |
5236 | MMSL |
d03157 | MMSL |
004016 | NDDF |
004017 | NDDF |
008361 | NDDF |
1269153001 | SNOMEDCT_US |
321963000 | SNOMEDCT_US |
372595009 | SNOMEDCT_US |
411000220105 | SNOMEDCT_US |
420495003 | SNOMEDCT_US |
96214003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7001 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7001 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7002 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7002 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7003 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7003 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7004 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7004 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0574-0279 | CAPSULE | 7.50 mg | ORAL | NDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0574-0279 | CAPSULE | 7.50 mg | ORAL | NDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7985 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 24 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7985 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 24 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8173 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 24 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8173 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 24 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8174 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 24 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8174 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 24 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8359 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 25 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8359 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 25 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5676 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 37 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5676 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 37 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5677 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 37 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5677 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 37 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5678 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 37 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5678 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 37 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5679 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 37 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5679 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 37 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-433 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 32 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-809 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 32 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-248 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 31 sections |
Paroxetine | Human Prescription Drug Label | 1 | 13107-154 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 34 sections |