paroxetine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives 2068 61869-08-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • BRL 29060A
  • BRL-29060A
  • paroxetine hydrochloride hydrate
  • brisdelle
  • paroxetine
  • paxetil
  • paxil
  • paroxetine hydrochloride
  • paroxetine mesylate
  • paroxetine hydrochloride hemihydrate
  • paroxetine hydrochloride anhydrous
  • paroxetine mesilate
  • paroxetine HCl
A serotonin uptake inhibitor that is effective in the treatment of depression.
  • Molecular weight: 329.37
  • Formula: C19H20FNO3
  • CLOGP: 4.24
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 39.72
  • ALOGS: -4.59
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 5.40 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.53 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 18 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 18 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.06 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 13 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK3,MAP3K7,MAPK10,MAPK12,MAPK7,MET,NTRK2,PDK2,PDK4,PIM2,PRKDC,SIK2,SIK3,TEK,TGFBR1 32
kinase-selectivity-class EIF2AK3,PDK4 2
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.627 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
rat-kpuu-brain Rat brain Kpuu 0.262 % High 1

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1992 FDA APOTEX TECHNOLOGIES

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug withdrawal syndrome 1047.16 9.32 594 126224 28129 90473500
Serotonin syndrome 1033.57 9.32 650 126168 37237 90464392
Atrial septal defect 789.02 9.32 330 126488 7904 90493725
Suicidal ideation 705.78 9.32 680 126138 73175 90428454
Drug abuse 665.06 9.32 692 126126 81655 90419974
Suicide attempt 588.09 9.32 622 126196 74777 90426852
Drug interaction 552.49 9.32 1204 125614 275249 90226380
Sopor 545.31 9.32 371 126447 24273 90477356
Ventricular septal defect 433.36 9.32 191 126627 5216 90496413
Agitation 422.42 9.32 495 126323 66603 90435026
Patent ductus arteriosus 417.30 9.32 177 126641 4392 90497237
Tremor 355.69 9.32 710 126108 152463 90349166
Pemphigus 346.38 9.32 30 126788 326834 90174795
Hand deformity 337.74 9.32 19 126799 296343 90205286
Systemic lupus erythematosus 323.52 9.32 58 126760 361838 90139791
Glossodynia 321.49 9.32 37 126781 321742 90179887
Mydriasis 313.21 9.32 218 126600 14794 90486835
Somnolence 298.31 9.32 800 126018 208284 90293345
Intentional self-injury 291.23 9.32 276 126542 29058 90472571
Nightmare 284.39 9.32 239 126579 21486 90480143
Hallucinations, mixed 276.26 9.32 144 126674 5745 90495884
Hyponatraemia 265.55 9.32 581 126237 132957 90368672
Alopecia 263.20 9.32 186 126632 494885 90006744
Anxiety 261.49 9.32 989 125829 308783 90192846
Toxicity to various agents 258.85 9.32 938 125880 286908 90214721
Completed suicide 257.16 9.32 603 126215 144455 90357174
Anti-cyclic citrullinated peptide antibody positive 246.90 9.32 23 126795 236410 90265219
Heart disease congenital 245.74 9.32 91 126727 1558 90500071
Exposure during pregnancy 238.59 9.32 805 126013 237605 90264024
Pericarditis 237.69 9.32 45 126773 270106 90231523
Foetal exposure during pregnancy 229.75 9.32 292 126526 42683 90458946
Pulmonary valve stenosis 221.65 9.32 61 126757 367 90501262
Disorientation 220.60 9.32 290 126528 43824 90457805
Helicobacter infection 219.37 9.32 29 126789 226821 90274808
Contraindicated product administered 218.91 9.32 87 126731 320052 90181577
Irritability 217.59 9.32 259 126559 35403 90466226
Multiple congenital abnormalities 214.53 9.32 64 126754 533 90501096
Duodenal ulcer perforation 209.93 9.32 30 126788 221258 90280371
Off label use 209.61 9.32 815 126003 1101437 89400192
Cardiac murmur 209.45 9.32 186 126632 18008 90483621
Joint swelling 203.54 9.32 243 126575 503057 89998572
Swelling 196.84 9.32 178 126640 418880 90082749
Infusion related reaction 195.81 9.32 177 126641 416603 90085026
Mania 194.45 9.32 160 126658 13964 90487665
Depersonalisation/derealisation disorder 192.68 9.32 76 126742 1556 90500073
Abdominal discomfort 192.42 9.32 231 126587 477097 90024532
Neuroleptic malignant syndrome 189.23 9.32 162 126656 14934 90486695
Anger 183.84 9.32 153 126665 13567 90488062
Synovitis 182.98 9.32 118 126700 329634 90171995
Persistent foetal circulation 181.93 9.32 45 126773 164 90501465
Hallucination, auditory 181.29 9.32 162 126656 15813 90485816
Folliculitis 177.69 9.32 35 126783 204318 90297311
Poisoning deliberate 176.90 9.32 162 126656 16324 90485305
Aggression 176.57 9.32 202 126616 26466 90475163
Panic attack 175.06 9.32 200 126618 26165 90475464
Drug intolerance 167.54 9.32 229 126589 447362 90054267
Bradyphrenia 166.93 9.32 114 126704 7498 90494131
Overdose 162.51 9.32 538 126280 157171 90344458
Withdrawal syndrome 161.76 9.32 178 126640 22346 90479283
Muscle injury 160.60 9.32 27 126791 176627 90325002
Hypersensitivity 159.96 9.32 243 126575 454434 90047195
Mood swings 159.88 9.32 170 126648 20532 90481097
Inappropriate antidiuretic hormone secretion 157.45 9.32 164 126654 19341 90482288
Derealisation 157.45 9.32 64 126754 1421 90500208
Blister 156.02 9.32 81 126737 254917 90246712
Myoglobin urine present 155.10 9.32 53 126765 709 90500920
Wound 154.14 9.32 119 126699 302861 90198768
Disturbance in attention 153.33 9.32 253 126565 46856 90454773
Restlessness 153.17 9.32 218 126600 35502 90466127
Discomfort 152.40 9.32 98 126720 274237 90227392
Hyperhidrosis 151.29 9.32 477 126341 135828 90365801
Hepatic enzyme increased 149.12 9.32 171 126647 360565 90141064
Stomatitis 147.38 9.32 102 126716 274596 90227033
Mobility decreased 147.06 9.32 84 126734 250650 90250979
Congenital anomaly 146.21 9.32 98 126720 6249 90495380
Rash 144.40 9.32 599 126219 795501 89706128
Dyskinesia 143.62 9.32 214 126604 36320 90465309
Arthropathy 143.54 9.32 181 126637 366061 90135568
Coarctation of the aorta 141.21 9.32 47 126771 577 90501052
Irritable bowel syndrome 140.72 9.32 57 126761 207391 90294238
Sleep disorder due to general medical condition, insomnia type 138.45 9.32 11 126807 128683 90372946
Pulmonary artery stenosis congenital 137.87 9.32 43 126775 422 90501207
Activation syndrome 136.41 9.32 37 126781 209 90501420
Extrapyramidal disorder 135.06 9.32 139 126679 16164 90485465
Lower respiratory tract infection 134.56 9.32 93 126725 250566 90251063
Psoriatic arthropathy 133.18 9.32 77 126741 228258 90273371
Nasopharyngitis 132.43 9.32 229 126589 406875 90094754
Drug ineffective 127.22 9.32 1283 125535 1383015 89118614
Intentional overdose 126.61 9.32 352 126466 93482 90408147
Feeling of despair 124.13 9.32 69 126749 3135 90498494
Gastric pH decreased 123.76 9.32 48 126770 938 90500691
Fallot's tetralogy 123.32 9.32 27 126791 47 90501582
Rheumatoid arthritis 122.52 9.32 199 126619 362415 90139214
Treatment failure 120.32 9.32 149 126669 303779 90197850
Dissociation 118.28 9.32 88 126730 6627 90495002
Altered state of consciousness 117.27 9.32 180 126638 31352 90470277
Rheumatic fever 115.98 9.32 35 126783 153086 90348543
Drug dependence 115.58 9.32 172 126646 29155 90472474
Fibromyalgia 114.10 9.32 74 126744 206195 90295434
Impaired healing 112.84 9.32 97 126721 234102 90267527
C-reactive protein abnormal 112.49 9.32 21 126797 127408 90374221
Joint range of motion decreased 110.26 9.32 27 126791 135616 90366013
Tearfulness 108.18 9.32 73 126745 4707 90496922
Product use issue 106.87 9.32 186 126632 329733 90171896
Cogwheel rigidity 106.10 9.32 54 126764 2048 90499581
General physical health deterioration 105.51 9.32 211 126607 354904 90146725
Intentional product use issue 105.50 9.32 89 126729 216803 90284826
Developmental delay 104.66 9.32 50 126768 1650 90499979
Emotional disorder 103.35 9.32 116 126702 14881 90486748
Hallucination, visual 102.06 9.32 143 126675 22949 90478680
Infection 99.35 9.32 225 126593 361869 90139760
Hyperreflexia 99.22 9.32 79 126739 6578 90495051
Crying 99.05 9.32 149 126669 25496 90476133
Coma 95.55 9.32 270 126548 72362 90429267
Peripheral swelling 95.45 9.32 280 126538 412826 90088803
Pain 95.19 9.32 914 125904 995427 89506202
Confusional state 94.90 9.32 890 125928 385315 90116314
Hallucination 94.52 9.32 253 126565 65706 90435923
Abnormal behaviour 93.92 9.32 136 126682 22492 90479137
Talipes 93.16 9.32 46 126772 1634 90499995
Breath sounds abnormal 92.61 9.32 111 126707 15275 90486354
Muscle rigidity 92.38 9.32 107 126711 14202 90487427
Flat affect 92.36 9.32 46 126772 1665 90499964
Rhabdomyolysis 90.65 9.32 213 126605 51043 90450586
Liver injury 90.56 9.32 64 126754 170503 90331126
Nervousness 90.13 9.32 167 126651 33889 90467740
Depression 89.60 9.32 723 126095 299878 90201751
Gastrointestinal disorder 89.37 9.32 138 126680 256549 90245080
Depressed mood 89.14 9.32 209 126609 50013 90451616
H1N1 influenza 88.17 9.32 47 126771 1963 90499666
Blood creatine phosphokinase increased 86.51 9.32 164 126654 33859 90467770
Dystonia 86.29 9.32 112 126706 16707 90484922
Clonus 85.19 9.32 68 126750 5682 90495947
Psychotic disorder 84.99 9.32 155 126663 31075 90470554
Swollen joint count increased 84.97 9.32 25 126793 111181 90390448
Homicidal ideation 84.85 9.32 44 126774 1736 90499893
Thermal burn 83.59 9.32 72 126746 6690 90494939
Agoraphobia 83.37 9.32 31 126787 537 90501092
Seizure 83.27 9.32 428 126390 152201 90349428
Abnormal dreams 82.63 9.32 90 126728 11167 90490462
Therapeutic product effect decreased 80.64 9.32 167 126651 277404 90224225
Delusion 80.29 9.32 98 126720 13742 90487887
Transposition of the great vessels 79.91 9.32 25 126793 248 90501381
Congenital aortic stenosis 79.40 9.32 17 126801 25 90501604
Cyanosis 79.40 9.32 116 126702 19339 90482290
Bronchial neoplasm 78.06 9.32 29 126789 501 90501128
Vertigo 78.05 9.32 245 126573 69566 90432063
Myoclonus 77.81 9.32 114 126704 19054 90482575
Arthralgia 77.74 9.32 706 126112 777816 89723813
Impulsive behaviour 77.44 9.32 41 126777 1689 90499940
Speech disorder 76.90 9.32 186 126632 45399 90456230
Hyperprolactinaemia 75.73 9.32 62 126756 5371 90496258
Speech disorder developmental 74.56 9.32 33 126785 910 90500719
Electrocardiogram QT prolonged 74.41 9.32 247 126571 72209 90429420
Libido increased 74.32 9.32 40 126778 1704 90499925
Type 2 diabetes mellitus 73.91 9.32 106 126712 203138 90298491
Depressed level of consciousness 73.75 9.32 247 126571 72537 90429092
Fall 73.68 9.32 1012 125806 480798 90020831
Hypoplastic left heart syndrome 73.14 9.32 22 126796 189 90501440
Parkinsonism 72.68 9.32 94 126724 13971 90487658
Grip strength decreased 72.23 9.32 20 126798 92556 90409073
Bronchial haemorrhage 72.18 9.32 29 126789 624 90501005
Bursitis 71.74 9.32 48 126770 131606 90370023
Encephalopathy 71.50 9.32 183 126635 46261 90455368
Wheezing 71.06 9.32 141 126677 237939 90263690
Sinus tachycardia 70.71 9.32 136 126682 28377 90473252
Cardio-respiratory arrest 70.04 9.32 221 126597 62919 90438710
Drooling 70.01 9.32 55 126763 4491 90497138
Insomnia 70.01 9.32 744 126074 332730 90168899
Toxic encephalopathy 69.95 9.32 73 126745 8626 90493003
Ill-defined disorder 69.66 9.32 94 126724 184797 90316832
Feeling of body temperature change 69.53 9.32 60 126758 5589 90496040
Affective disorder 69.22 9.32 69 126749 7724 90493905
Rheumatoid factor positive 69.10 9.32 83 126735 171567 90330062
Sinusitis 68.49 9.32 248 126570 342840 90158789
Facet joint syndrome 68.39 9.32 26 126792 98363 90403266
Homicide 68.12 9.32 23 126795 296 90501333
Febrile neutropenia 67.61 9.32 73 126745 158276 90343353
Loss of consciousness 67.49 9.32 380 126438 139858 90361771
Lip dry 66.40 9.32 29 126789 100926 90400703
Nasal turbinate hypertrophy 65.72 9.32 30 126788 891 90500738
Maternal exposure during pregnancy 65.62 9.32 270 126548 359793 90141836
Amylase increased 65.38 9.32 64 126754 7008 90494621
Oedema 63.83 9.32 114 126704 200181 90301448
Emotional distress 63.35 9.32 151 126667 36511 90465118
Wound infection 63.27 9.32 35 126783 106367 90395262
Feeling jittery 63.23 9.32 92 126726 15279 90486350
Akathisia 63.09 9.32 78 126740 11081 90490548
Restless legs syndrome 63.02 9.32 113 126705 22357 90479272
Endometrial ablation 62.54 9.32 30 126788 999 90500630
Apathy 62.15 9.32 77 126741 10963 90490666
Menstrual disorder 61.38 9.32 58 126760 6080 90495549
Knee arthroplasty 59.47 9.32 21 126797 83161 90418468
Myelosuppression 59.29 9.32 4 126814 53587 90448042
Pulmonary valve stenosis congenital 58.33 9.32 18 126800 170 90501459
Renal ischaemia 58.17 9.32 25 126793 641 90500988
Bicuspid aortic valve 57.47 9.32 17 126801 137 90501492
Anomalous pulmonary venous connection 56.39 9.32 14 126804 52 90501577
Breast cancer stage III 55.95 9.32 24 126794 84423 90417206
Cleft palate 55.56 9.32 30 126788 1286 90500343
Muscle disorder 55.22 9.32 52 126766 5427 90496202
Therapeutic product ineffective 54.95 9.32 37 126781 2377 90499252
Hip arthroplasty 54.89 9.32 19 126799 76189 90425440
Galactorrhoea 54.24 9.32 48 126770 4624 90497005
Right ventricular hypertrophy 53.27 9.32 25 126793 792 90500837
Incontinence 53.23 9.32 79 126739 13356 90488273
Urticaria 53.00 9.32 241 126577 312493 90189136
Fear 52.37 9.32 88 126730 16534 90485095
Musculoskeletal pain 52.32 9.32 100 126718 171151 90330478
Hostility 52.12 9.32 35 126783 2238 90499391
Treatment noncompliance 51.92 9.32 175 126643 51552 90450077
Cough 50.93 9.32 305 126513 368657 90132972
Hepatocellular injury 50.83 9.32 120 126698 28838 90472791
Tinnitus 50.71 9.32 154 126664 42948 90458681
PCO2 increased 50.11 9.32 28 126790 1285 90500344
Balance disorder 50.01 9.32 268 126550 96812 90404817
Dependence 49.83 9.32 33 126785 2062 90499567
Parosmia 49.26 9.32 55 126763 7014 90494615
Loss of libido 49.06 9.32 28 126790 1339 90500290
Pneumonia 48.51 9.32 616 126202 637443 89864186
Bronchial disorder 48.37 9.32 29 126789 1521 90500108
Urinary retention 48.35 9.32 139 126679 37605 90464024
Substance abuse 48.26 9.32 48 126770 5358 90496271
Disorganised speech 48.03 9.32 31 126787 1854 90499775
Obsessive-compulsive disorder 47.81 9.32 44 126774 4460 90497169
Autoimmune disorder 47.46 9.32 24 126794 76720 90424909
Psychomotor hyperactivity 47.43 9.32 73 126745 12740 90488889
Tachycardia 47.33 9.32 380 126438 157293 90344336
Delirium 47.08 9.32 278 126540 104081 90397548
Hypoaesthesia oral 47.05 9.32 81 126737 15519 90486110
COVID-19 47.00 9.32 104 126714 168739 90332890
Craniosynostosis 46.97 9.32 15 126803 160 90501469
Troponin increased 46.85 9.32 74 126744 13207 90488422
Logorrhoea 46.39 9.32 35 126783 2692 90498937
Self-injurious ideation 45.59 9.32 37 126781 3166 90498463
Lower limb fracture 44.97 9.32 32 126786 84981 90416648
Paralysis 44.77 9.32 67 126751 11411 90490218
Product complaint 44.58 9.32 73 126745 13427 90488202
Paranoia 44.26 9.32 71 126747 12837 90488792
Bradycardia 44.23 9.32 233 126585 83614 90418015
Self esteem decreased 44.23 9.32 22 126796 794 90500835
Reversible cerebral vasoconstriction syndrome 43.17 9.32 40 126778 4090 90497539
Adjustment disorder with depressed mood 42.91 9.32 13 126805 56740 90444889
Spina bifida 42.66 9.32 22 126796 858 90500771
Peripheral venous disease 42.57 9.32 33 126785 83888 90417741
Deep vein thrombosis postoperative 42.52 9.32 23 126795 70786 90430843
Hypomania 42.18 9.32 57 126761 8840 90492789
Dislocation of vertebra 41.99 9.32 13 126805 55955 90445674
Sciatica 41.88 9.32 48 126770 101334 90400295
Blood lactate dehydrogenase increased 41.81 9.32 104 126714 25828 90475801
Malignant neoplasm progression 41.61 9.32 53 126765 106817 90394812
Rhonchi 41.54 9.32 34 126784 2944 90498685
Libido decreased 41.50 9.32 34 126784 2948 90498681
Congenital cardiovascular anomaly 41.23 9.32 18 126800 480 90501149
Muscle twitching 41.08 9.32 99 126719 24103 90477526
Maternal drugs affecting foetus 40.98 9.32 43 126775 5112 90496517
Neonatal behavioural syndrome 40.98 9.32 12 126806 93 90501536
Poisoning 40.74 9.32 75 126743 15142 90486487
Blood sodium decreased 40.64 9.32 107 126711 27506 90474123
Soft tissue injury 40.43 9.32 29 126789 2063 90499566
Coeliac disease 40.12 9.32 7 126811 44603 90457026
Soliloquy 39.88 9.32 16 126802 343 90501286
Pyrexia 39.61 9.32 668 126150 659817 89841812
Respiratory depression 39.49 9.32 75 126743 15500 90486129
Diabetes insipidus 39.30 9.32 34 126784 3178 90498451
Hyperacusis 39.02 9.32 32 126786 2779 90498850
Congenital mitral valve stenosis 39.01 9.32 7 126811 0 90501629
Disease progression 38.44 9.32 103 126715 156512 90345117
Depressive symptom 38.35 9.32 42 126776 5243 90496386
Alloimmunisation 38.11 9.32 8 126810 10 90501619
Injury 37.81 9.32 145 126673 197204 90304425
Blood pH decreased 37.36 9.32 30 126788 2528 90499101
Victim of crime 37.16 9.32 20 126798 852 90500777
Social anxiety disorder 37.10 9.32 18 126800 615 90501014
Vision blurred 37.10 9.32 273 126545 110020 90391609
Dizziness 37.08 9.32 1083 125735 588201 89913428
Granuloma skin 36.97 9.32 59 126759 10621 90491008
Bone erosion 36.86 9.32 14 126804 53007 90448622
PO2 increased 36.73 9.32 20 126798 872 90500757
Upper respiratory tract infection 36.56 9.32 78 126740 128240 90373389
Alanine aminotransferase increased 36.49 9.32 287 126531 118051 90383578
Prescribed overdose 36.38 9.32 50 126768 97575 90404054
Macular degeneration 36.33 9.32 5 126813 37965 90463664
Cognitive disorder 36.01 9.32 192 126626 69215 90432414
Dyspnoea 35.81 9.32 949 125869 880006 89621623
Chorea 35.71 9.32 27 126791 2083 90499546
Post-traumatic neck syndrome 35.69 9.32 29 126789 2485 90499144
Mood altered 35.64 9.32 76 126742 17068 90484561
Generalised anxiety disorder 35.49 9.32 30 126788 2717 90498912
Accidental poisoning 35.36 9.32 20 126798 940 90500689
Hypocoagulable state 35.18 9.32 24 126794 1575 90500054
Prescription form tampering 34.74 9.32 18 126800 709 90500920
Ventricular hypoplasia 34.68 9.32 12 126806 167 90501462
Bradykinesia 34.50 9.32 45 126773 6743 90494886
Injection site pain 34.33 9.32 126 126692 173573 90328056
Memory impairment 34.12 9.32 424 126394 196820 90304809
DiGeorge's syndrome 33.44 9.32 6 126812 0 90501629
Endocrine ophthalmopathy 33.27 9.32 20 126798 1054 90500575
Asphyxia 32.90 9.32 45 126773 7058 90494571
Increased appetite 32.78 9.32 59 126759 11706 90489923
Cardiomegaly 32.75 9.32 78 126740 18847 90482782
Alcoholism 32.62 9.32 24 126794 1776 90499853
Retinitis 32.55 9.32 7 126811 38451 90463178
Blood cholesterol increased 32.48 9.32 165 126653 207847 90293782
Osteoarthritis 32.44 9.32 152 126666 195578 90306051
Panniculitis 32.28 9.32 66 126752 14392 90487237
Mental disorder 32.13 9.32 109 126709 32209 90469420
Ebstein's anomaly 31.68 9.32 7 126811 13 90501616
Nail disorder 31.55 9.32 22 126796 59045 90442584
Feeling abnormal 31.33 9.32 365 126453 166870 90334759
Musculoskeletal stiffness 31.20 9.32 265 126553 296267 90205362
Blood parathyroid hormone decreased 31.19 9.32 59 126759 12157 90489472
Lupus vulgaris 31.15 9.32 12 126806 45047 90456582
Ear infection 31.09 9.32 31 126787 69744 90431885
Schizophrenia 30.87 9.32 66 126752 14848 90486781
Fatigue 30.73 9.32 1312 125506 1152711 89348918
Hypertonia 30.71 9.32 37 126781 5118 90496511
Aphasia 30.64 9.32 130 126688 42682 90458947
Therapy non-responder 30.54 9.32 94 126724 136610 90365019
Sensory disturbance 30.52 9.32 67 126751 15346 90486283
Electroencephalogram abnormal 30.50 9.32 33 126785 4063 90497566
Sternal fracture 30.25 9.32 28 126790 2859 90498770
Road traffic accident 30.18 9.32 66 126752 107560 90394069
Middle insomnia 30.03 9.32 70 126748 16681 90484948
Alcohol abuse 30.03 9.32 24 126794 2009 90499620
Live birth 30.00 9.32 40 126778 79067 90422562
Pain in extremity 29.87 9.32 447 126371 450082 90051547
Apraxia 29.83 9.32 25 126793 2237 90499392
Coma scale 29.52 9.32 8 126810 45 90501584
Dysmorphism 29.05 9.32 26 126792 2542 90499087
Cholestasis 28.97 9.32 114 126704 36185 90465444
Premature baby 28.93 9.32 89 126729 24988 90476641
Anhedonia 28.93 9.32 55 126763 11376 90490253
Toxic shock syndrome 28.67 9.32 18 126800 1026 90500603
Clinodactyly 28.53 9.32 10 126808 145 90501484
Feelings of worthlessness 28.51 9.32 13 126805 385 90501244
Vesicoureteric reflux 28.35 9.32 12 126806 296 90501333
Joint hyperextension 28.29 9.32 13 126805 392 90501237
Micrognathia 28.24 9.32 12 126806 299 90501330
Liver function test increased 28.20 9.32 47 126771 84808 90416821
Urticaria thermal 27.80 9.32 14 126804 519 90501110
Aortic valve incompetence 27.76 9.32 40 126778 6584 90495045
Lung disorder 27.51 9.32 112 126706 149771 90351858
Premature labour 27.46 9.32 59 126759 13317 90488312
Gait inability 27.16 9.32 109 126709 146347 90355282
Poor quality sleep 26.98 9.32 86 126732 24607 90477022
Tricuspid valve incompetence 26.87 9.32 67 126751 16664 90484965
Muscular weakness 26.85 9.32 174 126644 206492 90295137
Eye movement disorder 26.82 9.32 38 126780 6160 90495469
Dilatation ventricular 26.77 9.32 24 126794 2352 90499277
Creutzfeldt-Jakob disease 26.64 9.32 10 126808 178 90501451
Aorta hypoplasia 26.44 9.32 10 126808 182 90501447
Hypokinesia 26.42 9.32 64 126754 15633 90485996
Blood triglycerides increased 26.33 9.32 59 126759 13702 90487927
Death 26.27 9.32 465 126353 456086 90045543
Obsessive thoughts 26.06 9.32 14 126804 594 90501035
Violence-related symptom 26.00 9.32 14 126804 597 90501032
Neuropathy peripheral 25.99 9.32 101 126717 136869 90364760
Dizziness postural 25.99 9.32 46 126772 9007 90492622
Congenital heart valve disorder 25.98 9.32 8 126810 75 90501554
Hepatotoxicity 25.94 9.32 16 126802 45826 90455803
Antidepressant drug level above therapeutic 25.94 9.32 13 126805 477 90501152
Oxygen saturation abnormal 25.91 9.32 31 126787 4257 90497372
Disinhibition 25.83 9.32 17 126801 1051 90500578
Onychomycosis 25.76 9.32 10 126808 37366 90464263
Haemorrhagic stroke 25.45 9.32 38 126780 6458 90495171
Neutrophil count decreased 25.31 9.32 38 126780 71494 90430135
Skin necrosis 25.29 9.32 66 126752 16875 90484754
Dysarthria 25.12 9.32 146 126672 54336 90447293
Panic reaction 25.12 9.32 32 126786 4685 90496944
Lupus-like syndrome 25.04 9.32 19 126799 48827 90452802
Inflammation 24.94 9.32 147 126671 178445 90323184
Paraesthesia 24.84 9.32 490 126328 249836 90251793
Mental impairment 24.82 9.32 65 126753 16655 90484974
Blood bicarbonate decreased 24.77 9.32 26 126792 3093 90498536
Psychomotor skills impaired 24.72 9.32 25 126793 2847 90498782
Ventricular hypertrophy 24.69 9.32 27 126791 3364 90498265
Congenital aortic valve incompetence 24.67 9.32 6 126812 20 90501609
Respiratory distress 24.65 9.32 114 126704 38832 90462797
Heterophoria 24.53 9.32 7 126811 49 90501580
Cytomegalovirus infection 24.31 9.32 4 126814 26598 90475031
Drug abuser 24.23 9.32 24 126794 2666 90498963
Anorgasmia 24.22 9.32 14 126804 686 90500943
Hypoplastic right heart syndrome 24.16 9.32 7 126811 52 90501577
Finger deformity 24.04 9.32 8 126810 32889 90468740
Hot flush 24.00 9.32 154 126664 59334 90442295
Cerebral microhaemorrhage 23.84 9.32 10 126808 241 90501388
Major depression 23.83 9.32 47 126771 9988 90491641
Physical assault 23.64 9.32 15 126803 871 90500758
Congenital tricuspid valve atresia 23.39 9.32 7 126811 59 90501570
Lethargy 23.39 9.32 160 126658 62979 90438650
Tardive dyskinesia 23.35 9.32 49 126769 10881 90490748
Wound complication 23.32 9.32 31 126787 4732 90496897
Euphoric mood 23.16 9.32 33 126785 5376 90496253
Vulvovaginal burning sensation 23.09 9.32 23 126795 2572 90499057
Somnolence neonatal 23.08 9.32 8 126810 112 90501517
Negative thoughts 23.04 9.32 16 126802 1081 90500548
Tension 22.88 9.32 27 126791 3655 90497974
Psychiatric symptom 22.84 9.32 38 126780 7080 90494549
Palpitations 22.82 9.32 292 126526 136436 90365193
Generalised tonic-clonic seizure 22.71 9.32 103 126715 34800 90466829
Drug eruption 22.67 9.32 104 126714 35303 90466326
Tonic clonic movements 22.65 9.32 19 126799 1703 90499926
Compartment syndrome 22.63 9.32 24 126794 2888 90498741
Blood potassium increased 22.43 9.32 72 126746 20677 90480952
Eyelid disorder 22.38 9.32 21 126797 2182 90499447
Congenital aortic atresia 22.29 9.32 4 126814 0 90501629
Pilonidal cyst congenital 22.29 9.32 4 126814 0 90501629
Myoglobin blood increased 22.24 9.32 18 126800 1534 90500095
Sluggishness 22.13 9.32 34 126784 5925 90495704
Thinking abnormal 22.11 9.32 50 126768 11682 90489947
Frontotemporal dementia 22.04 9.32 11 126807 400 90501229
Altered visual depth perception 21.91 9.32 11 126807 405 90501224
Injection site erythema 21.81 9.32 68 126750 98434 90403195
Wolff-Parkinson-White syndrome 21.77 9.32 9 126809 209 90501420
Coronary artery disease 21.71 9.32 99 126719 33524 90468105
X-ray abnormal 21.63 9.32 19 126799 45405 90456224
Mitral valve incompetence 21.55 9.32 75 126743 22449 90479180
Phonophobia 21.19 9.32 11 126807 435 90501194
Granuloma 21.18 9.32 34 126784 6151 90495478
Hepatic encephalopathy 20.92 9.32 54 126764 13718 90487911
Parkinson's disease 20.81 9.32 15 126803 1075 90500554
Aspartate aminotransferase increased 20.78 9.32 228 126590 102709 90398920
Mental status changes 20.77 9.32 120 126698 44559 90457070
Hypotonia 20.76 9.32 48 126770 11378 90490251
Hepatic cytolysis 20.69 9.32 92 126726 30824 90470805
Immunodeficiency 20.69 9.32 18 126800 43216 90458413
Antidepressant discontinuation syndrome 20.50 9.32 8 126810 159 90501470
Product dose omission issue 20.50 9.32 286 126532 291401 90210228
Breast cancer stage II 20.46 9.32 12 126806 35322 90466307
Drug level increased 20.41 9.32 85 126733 27677 90473952
Gamma-glutamyltransferase increased 20.38 9.32 106 126712 37846 90463783
Bronchopulmonary dysplasia 20.32 9.32 12 126806 612 90501017
Night sweats 20.17 9.32 102 126716 128664 90372965
Apallic syndrome 20.06 9.32 13 126805 783 90500846
Bipolar disorder 20.04 9.32 41 126777 8944 90492685
Mucosal inflammation 20.01 9.32 31 126787 57594 90444035
Anaemia neonatal 20.00 9.32 10 126808 365 90501264
Onychomadesis 19.85 9.32 21 126797 45977 90455652
Immature respiratory system 19.70 9.32 6 126812 54 90501575
Velopharyngeal incompetence 19.65 9.32 5 126813 21 90501608
Mitochondrial toxicity 19.65 9.32 12 126806 651 90500978
Liver disorder 19.61 9.32 95 126723 121174 90380455
Failure to thrive 19.50 9.32 39 126779 8372 90493257
Frequent bowel movements 19.42 9.32 31 126787 56904 90444725
Metastases to liver 19.38 9.32 8 126810 28799 90472830
Respiratory tract infection 19.37 9.32 33 126785 59045 90442584
Colitis microscopic 19.32 9.32 46 126772 11113 90490516
Staphylococcal infection 19.30 9.32 125 126693 48314 90453315
Walking aid user 19.26 9.32 13 126805 35493 90466136
Lividity 19.18 9.32 10 126808 399 90501230
Hypotension 19.06 9.32 593 126225 324804 90176825
Sedation 19.00 9.32 124 126694 48047 90453582
Congenital aortic anomaly 18.96 9.32 6 126812 62 90501567
Pulmonary artery stenosis 18.92 9.32 9 126809 294 90501335
Sudden death 18.92 9.32 45 126773 10864 90490765
Product use in unapproved indication 18.84 9.32 344 126474 335892 90165737
Illusion 18.84 9.32 15 126803 1249 90500380
Adverse reaction 18.81 9.32 9 126809 29703 90471926
Apnoea 18.73 9.32 41 126777 9373 90492256
Cholecystitis chronic 18.65 9.32 42 126776 9784 90491845
Toxicologic test abnormal 18.56 9.32 12 126806 720 90500909
Slow response to stimuli 18.49 9.32 14 126804 1082 90500547
Haemorrhagic diathesis 18.42 9.32 30 126788 5494 90496135
Hepatic cirrhosis 18.39 9.32 38 126780 63215 90438414
Trichotillomania 18.33 9.32 7 126811 131 90501498
Sepsis 18.32 9.32 162 126656 179652 90321977
Foetal movement disorder 18.26 9.32 4 126814 7 90501622
Cleft lip and palate 18.20 9.32 12 126806 744 90500885
Impatience 18.18 9.32 10 126808 445 90501184
Hypercholesterolaemia 18.13 9.32 76 126742 100816 90400813
Accidental overdose 18.07 9.32 83 126735 28190 90473439
Panic disorder 17.97 9.32 22 126796 3093 90498536
Social avoidant behaviour 17.93 9.32 23 126795 3390 90498239
Dyspepsia 17.86 9.32 184 126634 197976 90303653
Skin laceration 17.82 9.32 78 126740 25957 90475672
Dry mouth 17.81 9.32 168 126650 183891 90317738
Osteoporosis 17.79 9.32 72 126746 96459 90405170
Bruxism 17.78 9.32 26 126792 4337 90497292
Brugada syndrome 17.78 9.32 10 126808 465 90501164
Muscle tightness 17.70 9.32 50 126768 13389 90488240
Catatonia 17.68 9.32 31 126787 6025 90495604
Cleft uvula 17.59 9.32 4 126814 9 90501620
Antisocial personality disorder 17.59 9.32 4 126814 9 90501620
Hospitalisation 17.59 9.32 106 126712 127994 90373635
Dissociative disorder 17.55 9.32 11 126807 625 90501004
Persecutory delusion 17.46 9.32 22 126796 3186 90498443
Congenital tracheomalacia 17.40 9.32 5 126813 36 90501593
Subdural haematoma 17.31 9.32 57 126761 16588 90485041
Maternal exposure timing unspecified 17.27 9.32 5 126813 22478 90479151
Abdominal pain upper 17.21 9.32 345 126473 332329 90169300
Trismus 17.19 9.32 27 126791 4794 90496835
Respiratory arrest 17.17 9.32 92 126726 33219 90468410
Pneumonitis 17.09 9.32 22 126796 44148 90457481
Feeling guilty 17.05 9.32 11 126807 657 90500972
Pulmonary valve incompetence 17.03 9.32 16 126802 1665 90499964
Poriomania 16.99 9.32 6 126812 89 90501540
Laryngitis 16.97 9.32 28 126790 50725 90450904
Anaphylactic reaction 16.95 9.32 64 126754 87460 90414169
Campylobacter colitis 16.94 9.32 5 126813 40 90501589
Arthritis 16.93 9.32 151 126667 167164 90334465
Pruritus 16.87 9.32 604 126214 540921 89960708
Injection site reaction 16.77 9.32 69 126749 92011 90409618
Chemical submission 16.76 9.32 10 126808 520 90501109
Interruption of aortic arch 16.72 9.32 3 126815 0 90501629
Subvalvular aortic stenosis 16.72 9.32 3 126815 0 90501629
Lipomeningocele 16.72 9.32 3 126815 0 90501629
Neutropenia 16.71 9.32 218 126600 224686 90276943
Flank pain 16.68 9.32 62 126756 19160 90482469
Diabetic hyperosmolar coma 16.64 9.32 9 126809 387 90501242
Post procedural haematuria 16.62 9.32 5 126813 43 90501586
Hypoglycaemia 16.61 9.32 160 126658 69688 90431941
Lactose intolerance 16.61 9.32 22 126796 3347 90498282
Antidepressant drug level increased 16.60 9.32 9 126809 389 90501240
Rhinalgia 16.54 9.32 19 126799 2499 90499130
Therapy interrupted 16.42 9.32 28 126790 50080 90451549
Mitochondrial encephalomyopathy 16.40 9.32 6 126812 99 90501530
Perseveration 16.39 9.32 8 126810 277 90501352
Scratch 16.36 9.32 40 126778 9826 90491803
Arnold-Chiari malformation 16.33 9.32 11 126807 707 90500922
Suicidal behaviour 16.27 9.32 20 126798 2824 90498805
Administration site erythema 16.20 9.32 12 126806 897 90500732
Hyperthermia 16.19 9.32 41 126777 10294 90491335
Yawning 16.15 9.32 13 126805 1099 90500530
Tethered cord syndrome 16.15 9.32 8 126810 286 90501343
Asthma 16.11 9.32 240 126578 241920 90259709
Autoimmune nephritis 16.11 9.32 9 126809 413 90501216
Seronegative arthritis 16.10 9.32 3 126815 18231 90483398
Fluid retention 16.05 9.32 66 126752 88025 90413604
Torsade de pointes 15.80 9.32 52 126766 15130 90486499
Respiratory acidosis 15.74 9.32 35 126783 8084 90493545
C-reactive protein increased 15.71 9.32 170 126648 181219 90320410
Food allergy 15.70 9.32 8 126810 25470 90476159
Female genital tract fistula 15.64 9.32 3 126815 17865 90483764
Otospondylomegaepiphyseal dysplasia 15.53 9.32 6 126812 116 90501513
Intra-abdominal haematoma 15.49 9.32 17 126801 2127 90499502
Ankle fracture 15.47 9.32 63 126755 20307 90481322
Gaze palsy 15.45 9.32 15 126803 1626 90500003
Drug resistance 15.41 9.32 12 126806 30437 90471192
Polydactyly 15.39 9.32 8 126810 317 90501312
Neonatal seizure 15.36 9.32 10 126808 607 90501022
Posterior reversible encephalopathy syndrome 15.36 9.32 6 126812 22333 90479296
Oesophageal atresia 15.17 9.32 10 126808 620 90501009
Drug hypersensitivity 15.15 9.32 514 126304 463095 90038534
Plagiocephaly 15.11 9.32 6 126812 125 90501504
Basal cell carcinoma 15.08 9.32 89 126729 33300 90468329
C-reactive protein 15.08 9.32 13 126805 31354 90470275
Congenital muscle absence 14.99 9.32 4 126814 21 90501608
Female orgasmic disorder 14.98 9.32 5 126813 62 90501567
Malaise 14.93 9.32 669 126149 585317 89916312
Ear pain 14.88 9.32 37 126781 57665 90443964
VACTERL syndrome 14.84 9.32 4 126814 22 90501607
Atrioventricular septal defect 14.82 9.32 8 126810 343 90501286
Abortion missed 14.81 9.32 16 126802 1966 90499663
Dyskinesia neonatal 14.64 9.32 3 126815 3 90501626
Marcus Gunn syndrome 14.64 9.32 3 126815 3 90501626
Leucine aminopeptidase increased 14.64 9.32 3 126815 3 90501626
Amnesia 14.57 9.32 223 126595 108282 90393347
Neonatal asphyxia 14.56 9.32 8 126810 355 90501274
Right aortic arch 14.54 9.32 7 126811 235 90501394
Oscillopsia 14.52 9.32 6 126812 139 90501490
Intestinal infarction 14.50 9.32 12 126806 1055 90500574
Gynaecomastia 14.40 9.32 7 126811 240 90501389
Drowning 14.38 9.32 9 126809 510 90501119
Product label confusion 14.34 9.32 7 126811 22843 90478786
Muscle spasticity 14.29 9.32 17 126801 35305 90466324
Resting tremor 14.29 9.32 11 126807 872 90500757
Rheumatoid nodule 14.25 9.32 61 126757 20105 90481524
Psoriasis 14.23 9.32 135 126683 147619 90354010
Personality disorder 14.20 9.32 44 126774 12400 90489229
Nodule 14.17 9.32 10 126808 26676 90474953
Left ventricular dysfunction 14.17 9.32 49 126769 14620 90487009
Prescription drug used without a prescription 14.15 9.32 20 126798 3235 90498394
Chronic spontaneous urticaria 14.15 9.32 15 126803 1805 90499824
Legal problem 14.14 9.32 4 126814 27 90501602
Right ventricle outflow tract obstruction 14.14 9.32 4 126814 27 90501602
Muscle contracture 14.14 9.32 15 126803 1806 90499823
Mean cell haemoglobin increased 14.11 9.32 22 126796 3883 90497746
Communication disorder 14.10 9.32 20 126798 3246 90498383
Nasal ulcer 14.06 9.32 18 126800 2648 90498981
Blood lactic acid increased 13.93 9.32 35 126783 8743 90492886
Genital labial adhesions 13.89 9.32 4 126814 29 90501600
Cardiac valve disease 13.89 9.32 24 126794 4611 90497018
Posture abnormal 13.82 9.32 18 126800 2693 90498936
Amimia 13.81 9.32 5 126813 80 90501549
Small for dates baby 13.81 9.32 25 126793 4982 90496647
Sensory loss 13.81 9.32 56 126762 18019 90483610
Tri-iodothyronine free decreased 13.78 9.32 8 126810 395 90501234
Hyporesponsive to stimuli 13.78 9.32 14 126804 1603 90500026
Colitis ulcerative 13.77 9.32 41 126777 60225 90441404
Electrocardiogram repolarisation abnormality 13.75 9.32 13 126805 1363 90500266
Hyperlipidaemia 13.71 9.32 66 126752 22850 90478779
Antipsychotic drug level above therapeutic 13.69 9.32 13 126805 1371 90500258
Posturing 13.67 9.32 9 126809 557 90501072
Product selection error 13.55 9.32 7 126811 274 90501355
Tracheal injury 13.50 9.32 6 126812 167 90501462
Oculogyric crisis 13.49 9.32 17 126801 2462 90499167
Ligament sprain 13.44 9.32 48 126770 14551 90487078
Asplenia 13.43 9.32 3 126815 6 90501623
Myocarditis bacterial 13.43 9.32 3 126815 6 90501623
Pseudohallucination 13.37 9.32 6 126812 171 90501458
Serum sickness-like reaction 13.35 9.32 9 126809 579 90501050
Psychomotor retardation 13.32 9.32 24 126794 4765 90496864
Sexual dysfunction 13.27 9.32 24 126794 4780 90496849
Thrombocytopenia 13.15 9.32 209 126609 208516 90293113
Diet refusal 13.13 9.32 9 126809 595 90501034
Product substitution issue 13.13 9.32 55 126763 17953 90483676
Infusion site scar 13.11 9.32 9 126809 597 90501032
Abdominal wall cyst 13.04 9.32 4 126814 37 90501592
Anal atresia 12.97 9.32 8 126810 442 90501187
Glossoptosis 12.92 9.32 5 126813 97 90501532
White blood cell count decreased 12.77 9.32 161 126657 166948 90334681
Secretion discharge 12.75 9.32 50 126768 15846 90485783
Mutism 12.73 9.32 14 126804 1755 90499874
Dyslipidaemia 12.73 9.32 37 126781 10070 90491559
Localised infection 12.69 9.32 17 126801 33545 90468084
Dextrocardia 12.67 9.32 4 126814 41 90501588
Incoherent 12.66 9.32 24 126794 4953 90496676
Behaviour disorder 12.60 9.32 23 126795 4612 90497017
Marital problem 12.59 9.32 6 126812 197 90501432
Hepatitis fulminant 12.58 9.32 21 126797 3924 90497705
Ventricular tachycardia 12.57 9.32 68 126750 24640 90476989
Cystocele 12.56 9.32 13 126805 1521 90500108
Blood aldosterone abnormal 12.50 9.32 4 126814 43 90501586
Proctitis 12.47 9.32 3 126815 15256 90486373
Concussion 12.46 9.32 39 126779 11052 90490577
Pancytopenia 12.40 9.32 108 126710 120155 90381474
Congenital neurological disorder 12.34 9.32 3 126815 10 90501619
Bundle branch block right 12.30 9.32 25 126793 5428 90496201
Double outlet right ventricle 12.25 9.32 4 126814 46 90501583
Long QT syndrome 12.22 9.32 21 126797 4016 90497613
Arrhythmia 12.14 9.32 101 126717 42231 90459398
Vascular access site pain 12.11 9.32 8 126810 498 90501131
Vitamin B12 deficiency 12.04 9.32 30 126788 7456 90494173
Supraventricular tachycardia 12.00 9.32 50 126768 16286 90485343
Blood chloride decreased 11.98 9.32 27 126791 6292 90495337
Hyperventilation 11.93 9.32 28 126790 6700 90494929
Pneumonia aspiration 11.91 9.32 98 126720 40842 90460787
Alcohol poisoning 11.85 9.32 14 126804 1898 90499731
Cardiac failure congestive 11.81 9.32 199 126619 98495 90403134
Hypoosmolar state 11.80 9.32 6 126812 227 90501402
Respiratory failure 11.80 9.32 232 126586 118186 90383443
Congenital diaphragmatic hernia 11.68 9.32 6 126812 232 90501397
Temperature regulation disorder 11.65 9.32 3 126815 14576 90487053
Rib fracture 11.64 9.32 70 126748 26365 90475264
Gastrointestinal ulcer haemorrhage 11.62 9.32 10 126808 928 90500701
Oliguria 11.61 9.32 37 126781 10587 90491042
Exostosis 11.54 9.32 37 126781 53097 90448532
Affect lability 11.52 9.32 53 126765 18010 90483619
Device expulsion 11.52 9.32 25 126793 40861 90460768
Hydrocephalus 11.51 9.32 26 126792 6068 90495561
Urinary incontinence 11.51 9.32 91 126727 37475 90464154
Housebound 11.49 9.32 6 126812 240 90501389
Hypersomnia 11.46 9.32 60 126758 21471 90480158
Laboratory test abnormal 11.46 9.32 26 126792 41828 90459801
Acute hepatic failure 11.42 9.32 62 126756 22499 90479130
Vasculitis 11.41 9.32 9 126809 22684 90478945
Mitral valve prolapse 11.38 9.32 16 126802 2575 90499054
Gastrointestinal anastomotic stenosis 11.37 9.32 3 126815 15 90501614
Injection site pruritus 11.33 9.32 38 126780 53796 90447833
Cerebral haematoma 11.31 9.32 21 126797 4268 90497361
Decreased activity 11.31 9.32 31 126787 8161 90493468
Malocclusion 11.29 9.32 5 126813 138 90501491
Pelvic pain 11.27 9.32 47 126771 15310 90486319
Exomphalos 11.26 9.32 8 126810 561 90501068
Fibrocystic breast disease 11.25 9.32 11 126807 1203 90500426
Cerebellar haematoma 11.24 9.32 7 126811 393 90501236
Hypochloraemia 11.23 9.32 16 126802 2606 90499023
Clostridium difficile infection 11.21 9.32 21 126797 36224 90465405
Intentional device use issue 11.19 9.32 5 126813 141 90501488
Limb injury 11.17 9.32 79 126739 31429 90470200
Gastric infection 11.14 9.32 20 126798 3960 90497669
Breast enlargement 11.12 9.32 13 126805 1742 90499887
Paroxysmal arrhythmia 11.11 9.32 4 126814 63 90501566
Haematocrit decreased 11.04 9.32 98 126720 41734 90459895
Accommodation disorder 11.02 9.32 7 126811 407 90501222
Hypoprothrombinaemia 11.01 9.32 7 126811 408 90501221
Arteriosclerosis coronary artery 11.00 9.32 34 126784 9569 90492060
Parkinsonian gait 10.97 9.32 8 126810 584 90501045
Delusion of grandeur 10.97 9.32 6 126812 264 90501365
Bladder dilatation 10.94 9.32 10 126808 1005 90500624
Congenital scoliosis 10.94 9.32 4 126814 66 90501563
Syndactyly 10.93 9.32 8 126810 587 90501042
Hypothermia 10.92 9.32 47 126771 15528 90486101
Hypercapnic coma 10.91 9.32 6 126812 267 90501362
Delivery 10.90 9.32 13 126805 1780 90499849
Congenital pulmonary valve disorder 10.88 9.32 4 126814 67 90501562
Inappropriate affect 10.85 9.32 10 126808 1015 90500614
Oxygen saturation decreased 10.85 9.32 211 126607 107272 90394357
Aortic stenosis 10.84 9.32 26 126792 6310 90495319
Palmar-plantar erythrodysaesthesia syndrome 10.80 9.32 14 126804 28009 90473620
Gestational diabetes 10.79 9.32 36 126782 10546 90491083
Congenital coronary artery malformation 10.78 9.32 5 126813 154 90501475
Therapy partial responder 10.76 9.32 9 126809 22034 90479595
Cerebral ventricle dilatation 10.68 9.32 10 126808 1036 90500593
Premature delivery 10.68 9.32 24 126794 38738 90462891
Phaeochromocytoma 10.67 9.32 8 126810 609 90501020
Normetanephrine urine increased 10.64 9.32 3 126815 20 90501609
Pallor 10.60 9.32 83 126735 34082 90467547
Diabetes mellitus 10.59 9.32 138 126680 64737 90436892
Hypersexuality 10.57 9.32 8 126810 618 90501011
Poor sucking reflex 10.56 9.32 7 126811 438 90501191
Porphyria acute 10.56 9.32 6 126812 17969 90483660
Neonatal respiratory distress syndrome 10.55 9.32 17 126801 3084 90498545
Delusional disorder, unspecified type 10.55 9.32 7 126811 439 90501190
Energy increased 10.44 9.32 17 126801 3113 90498516
Eye pain 10.42 9.32 101 126717 44067 90457562
Vessel puncture site bruise 10.41 9.32 7 126811 449 90501180
Hanging 10.39 9.32 3 126815 22 90501607
Therapeutic response shortened 10.38 9.32 10 126808 22869 90478760
Pulmonary embolism 10.37 9.32 248 126570 130572 90371057
Diabetic neuropathy 10.35 9.32 21 126797 4553 90497076
Wrong patient 10.34 9.32 9 126809 848 90500781
Condition aggravated 10.33 9.32 706 126112 594839 89906790
Helplessness 10.25 9.32 6 126812 301 90501328
Weight increased 10.18 9.32 697 126121 417230 90084399
Aeromonas infection 10.17 9.32 5 126813 176 90501453
Hyponatraemic coma 10.16 9.32 3 126815 24 90501605
Deafness 10.16 9.32 60 126758 22454 90479175
Leukopenia 10.13 9.32 91 126727 100619 90401010
Ataxia 10.11 9.32 51 126767 17991 90483638
Skin haemorrhage 10.11 9.32 9 126809 21371 90480258
Device difficult to use 10.08 9.32 6 126812 17519 90484110
Carotid artery disease 10.05 9.32 12 126806 1645 90499984
Cerebrovascular accident 10.04 9.32 235 126583 123298 90378331
Cholelithiasis 10.00 9.32 115 126703 52391 90449238
Postural tremor 10.00 9.32 7 126811 479 90501150
Sacroiliac joint dysfunction 9.96 9.32 4 126814 86 90501543
Third stage postpartum haemorrhage 9.95 9.32 3 126815 26 90501603
Mitral valve atresia 9.95 9.32 3 126815 26 90501603
Rash erythematous 9.95 9.32 52 126766 65052 90436577
Stupor 9.93 9.32 23 126795 5459 90496170
Blepharitis 9.90 9.32 19 126799 3957 90497672
Poverty of speech 9.88 9.32 6 126812 322 90501307
Dilatation atrial 9.86 9.32 13 126805 1968 90499661
Oedema peripheral 9.86 9.32 280 126538 257635 90243994
Thoracic radiculopathy 9.85 9.32 3 126815 27 90501602
Gingival disorder 9.85 9.32 19 126799 3972 90497657
Economic problem 9.85 9.32 17 126801 3264 90498365
Vulvovaginal pruritus 9.84 9.32 19 126799 3974 90497655
Angina unstable 9.83 9.32 27 126791 7116 90494513
Sleep disorder due to a general medical condition 9.82 9.32 31 126787 44707 90456922
Circadian rhythm sleep disorder 9.75 9.32 8 126810 695 90500934
Liposarcoma 9.74 9.32 5 126813 193 90501436
Drug withdrawal syndrome neonatal 9.71 9.32 14 126804 2305 90499324
Alcohol use 9.70 9.32 12 126806 1705 90499924
Poor dental condition 9.70 9.32 7 126811 503 90501126
Neoplasm progression 9.64 9.32 31 126787 44455 90457174
Injection site swelling 9.60 9.32 47 126771 59792 90441837
Large for dates baby 9.59 9.32 7 126811 512 90501117
Inferior vena caval occlusion 9.57 9.32 3 126815 30 90501599
Atrioventricular block second degree 9.56 9.32 20 126798 4432 90497197
Blood cholinesterase decreased 9.51 9.32 5 126813 203 90501426
No adverse event 9.46 9.32 56 126762 67926 90433703
Nephrogenic diabetes insipidus 9.38 9.32 9 126809 961 90500668
Orgasm abnormal 9.36 9.32 4 126814 101 90501528
Spondyloarthropathy 9.36 9.32 10 126808 1214 90500415
Product dispensing error 9.36 9.32 38 126780 12235 90489394
Postoperative delirium 9.33 9.32 5 126813 211 90501418

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Exposure during pregnancy 1907.15 11.49 638 59691 7910 42553096
Atrial septal defect 825.43 11.49 338 59991 7581 42553425
Ventricular septal defect 553.08 11.49 215 60114 4184 42556822
Patent ductus arteriosus 498.46 11.49 187 60142 3289 42557717
Serotonin syndrome 486.90 11.49 354 59975 25491 42535515
Drug withdrawal syndrome 451.63 11.49 315 60014 21234 42539772
Foetal exposure during pregnancy 433.96 11.49 428 59901 46883 42514123
Suicidal ideation 314.65 11.49 364 59965 47797 42513209
Congenital anomaly 311.82 11.49 107 60222 1434 42559572
Suicide attempt 298.77 11.49 347 59982 45753 42515253
Poisoning deliberate 294.98 11.49 182 60147 9952 42551054
Cardiac murmur 284.68 11.49 194 60135 12581 42548425
Multiple congenital abnormalities 258.00 11.49 73 60256 487 42560519
Heart disease congenital 256.67 11.49 91 60238 1351 42559655
Completed suicide 254.67 11.49 475 59854 95990 42465016
Drug abuse 250.94 11.49 495 59834 104276 42456730
Aggression 247.80 11.49 309 60020 43854 42517152
Talipes 238.23 11.49 97 60232 2139 42558867
Pulmonary valve stenosis 228.50 11.49 63 60266 377 42560629
Anxiety 225.68 11.49 510 59819 118050 42442956
Irritability 206.51 11.49 226 60103 27902 42533104
Coarctation of the aorta 196.78 11.49 57 60272 418 42560588
Coma 180.70 11.49 294 60035 53260 42507746
Persistent foetal circulation 175.94 11.49 49 60280 306 42560700
Off label use 169.23 11.49 413 59916 637922 41923084
Hypoplastic left heart syndrome 166.23 11.49 43 60286 193 42560813
Agitation 161.29 11.49 310 60019 64004 42497002
Pulmonary artery stenosis congenital 160.74 11.49 50 60279 480 42560526
Fallot's tetralogy 157.26 11.49 39 60290 142 42560864
Intentional overdose 156.92 11.49 270 60059 51186 42509820
Bicuspid aortic valve 153.79 11.49 43 60286 273 42560733
Sopor 144.85 11.49 132 60197 13070 42547936
Intentional self-injury 141.95 11.49 139 60190 15063 42545943
Febrile neutropenia 135.34 11.49 47 60282 185656 42375350
Tremor 133.72 11.49 369 59960 96560 42464446
Transposition of the great vessels 133.22 11.49 42 60287 423 42560583
Mania 124.69 11.49 110 60219 10437 42550569
Congenital aortic stenosis 120.76 11.49 28 60301 70 42560936
Insomnia 120.71 11.49 405 59924 117848 42443158
Extrapyramidal disorder 120.66 11.49 132 60197 16280 42544726
Panic attack 110.68 11.49 105 60224 10940 42550066
Neuroleptic malignant syndrome 110.51 11.49 144 60185 21328 42539678
Withdrawal syndrome 108.90 11.49 119 60210 14656 42546350
Disturbance in attention 107.59 11.49 169 60160 29697 42531309
Impulsive behaviour 103.81 11.49 56 60273 2369 42558637
Somnolence 102.23 11.49 433 59896 140672 42420334
Craniosynostosis 98.94 11.49 33 60296 403 42560603
Depression 97.78 11.49 363 59966 111000 42450006
Developmental delay 94.75 11.49 58 60271 3124 42557882
Homicide 91.71 11.49 38 60291 877 42560129
Congenital cardiovascular anomaly 87.68 11.49 25 60304 172 42560834
Toxicity to various agents 86.75 11.49 588 59741 228548 42332458
Activation syndrome 86.71 11.49 24 60305 146 42560860
Sexual dysfunction 82.77 11.49 72 60257 6703 42554303
Confusional state 82.26 11.49 460 59869 167137 42393869
Drug ineffective 81.52 11.49 541 59788 629656 41931350
Anger 77.65 11.49 94 60235 12924 42548082
Pneumonia 72.81 11.49 329 60000 421820 42139186
Drug dependence 72.57 11.49 140 60189 28954 42532052
Cleft palate 72.47 11.49 29 60300 610 42560396
Disease progression 71.51 11.49 59 60270 143597 42417409
Double outlet right ventricle 69.59 11.49 19 60310 109 42560897
COVID-19 69.21 11.49 39 60290 115909 42445097
Overdose 67.81 11.49 312 60017 104952 42456054
Cogwheel rigidity 67.23 11.49 38 60291 1763 42559243
Mood swings 66.63 11.49 72 60257 8754 42552252
Congenital aortic atresia 66.32 11.49 14 60315 18 42560988
Erectile dysfunction 66.00 11.49 123 60206 24790 42536216
Sepsis 64.17 11.49 115 60214 199219 42361787
Acute kidney injury 63.45 11.49 286 60043 367051 42193955
Pulmonary malformation 62.20 11.49 14 60315 29 42560977
Hypoplastic right heart syndrome 59.48 11.49 12 60317 10 42560996
Altered state of consciousness 59.04 11.49 129 60200 29130 42531876
Parkinsonism 58.99 11.49 74 60255 10549 42550457
Speech disorder developmental 56.42 11.49 37 60292 2248 42558758
Head titubation 55.68 11.49 22 60307 447 42560559
Tricuspid valve incompetence 54.80 11.49 73 60256 11040 42549966
Inappropriate antidiuretic hormone secretion 54.64 11.49 90 60239 16451 42544555
Mydriasis 53.40 11.49 64 60265 8706 42552300
Gun shot wound 53.10 11.49 27 60302 1010 42559996
Diarrhoea 52.88 11.49 409 59920 460440 42100566
Cleft lip and palate 52.83 11.49 26 60303 906 42560100
Nervousness 50.71 11.49 78 60251 13454 42547552
Hyperhidrosis 50.16 11.49 257 60072 90255 42470751
Anticholinergic syndrome 49.98 11.49 30 60299 1559 42559447
Drug withdrawal syndrome neonatal 49.70 11.49 45 60284 4416 42556590
Affect lability 49.45 11.49 43 60286 4001 42557005
Maternal drugs affecting foetus 49.34 11.49 42 60287 3797 42557209
Pulmonary valve stenosis congenital 49.28 11.49 15 60314 133 42560873
Arnold-Chiari malformation 48.88 11.49 19 60310 369 42560637
Rash 48.74 11.49 214 60115 276740 42284266
Drug interaction 48.44 11.49 584 59745 266415 42294591
Hamartoma 48.32 11.49 12 60317 44 42560962
Asphyxia 47.84 11.49 59 60270 8267 42552739
Congenital aortic valve incompetence 47.67 11.49 15 60314 150 42560856
Plagiocephaly 47.15 11.49 21 60308 581 42560425
Depressed mood 47.07 11.49 103 60226 23281 42537725
Visceral congestion 46.73 11.49 24 60305 917 42560089
Sleep disorder 46.60 11.49 162 60167 47933 42513073
Hypomania 46.38 11.49 34 60295 2474 42558532
Death 44.79 11.49 439 59890 470746 42090260
Akathisia 44.56 11.49 64 60265 10387 42550619
Dyspnoea 44.36 11.49 407 59922 442214 42118792
Product use in unapproved indication 44.18 11.49 125 60204 184331 42376675
Ventricular hypoplasia 44.07 11.49 12 60317 68 42560938
Depressed level of consciousness 43.41 11.49 158 60171 47812 42513194
Abnormal behaviour 42.84 11.49 107 60222 26344 42534662
Hyper IgE syndrome 42.50 11.49 14 60315 164 42560842
Hangover 42.45 11.49 24 60305 1114 42559892
Ejaculation delayed 42.03 11.49 16 60313 293 42560713
Intentional product use issue 41.65 11.49 25 60304 71808 42489198
Thinking abnormal 41.55 11.49 51 60278 7110 42553896
Pyrexia 41.36 11.49 358 59971 393684 42167322
Right aortic arch 41.25 11.49 9 60320 15 42560991
Poisoning 40.72 11.49 74 60255 14625 42546381
Choanal atresia 40.62 11.49 8 60321 5 42561001
Congenital tricuspid valve atresia 40.19 11.49 12 60317 99 42560907
Malignant neoplasm progression 40.07 11.49 57 60272 108343 42452663
Restlessness 39.91 11.49 111 60218 29138 42531868
Pancytopenia 39.61 11.49 66 60263 117677 42443329
Libido decreased 39.20 11.49 42 60287 5056 42555950
Thrombocytopenia 39.20 11.49 138 60191 190141 42370865
Bipolar disorder 38.74 11.49 37 60292 3885 42557121
Feeling of despair 38.49 11.49 23 60306 1185 42559821
Disorientation 38.27 11.49 126 60203 36263 42524743
Attention deficit hyperactivity disorder 37.90 11.49 33 60296 3075 42557931
Amnesia 37.90 11.49 107 60222 28330 42532676
Tremor neonatal 37.82 11.49 17 60312 481 42560525
Mitral valve stenosis 37.60 11.49 15 60314 313 42560693
Hyperreflexia 37.49 11.49 35 60294 3572 42557434
Hyperthermia 37.01 11.49 65 60264 12509 42548497
Agoraphobia 36.90 11.49 14 60315 254 42560752
Infection 36.61 11.49 64 60265 112004 42449002
Cytokine release syndrome 36.53 11.49 9 60320 44518 42516488
Dextrocardia 36.24 11.49 10 60319 60 42560946
Somnolence neonatal 35.73 11.49 8 60321 16 42560990
Right ventricular hypertrophy 35.59 11.49 24 60305 1528 42559478
Delirium 35.52 11.49 158 60171 52361 42508645
Physical assault 35.52 11.49 21 60308 1061 42559945
Homicidal ideation 34.75 11.49 30 60299 2764 42558242
Maternal exposure during pregnancy 34.66 11.49 46 60283 6932 42554074
Congenital aortic anomaly 34.56 11.49 10 60319 73 42560933
Renal impairment 34.18 11.49 65 60264 110163 42450843
Anaemia 33.83 11.49 245 60084 280033 42280973
Cough 33.53 11.49 134 60195 177969 42383037
Anencephaly 33.46 11.49 11 60318 128 42560878
Interruption of aortic arch 33.37 11.49 6 60323 0 42561006
DiGeorge's syndrome 33.37 11.49 6 60323 0 42561006
Memory impairment 33.15 11.49 150 60179 50072 42510934
Atrial fibrillation 33.11 11.49 95 60234 139498 42421508
Septic shock 33.09 11.49 49 60280 91623 42469383
General physical health deterioration 32.97 11.49 107 60222 151139 42409867
Hypertonia 32.95 11.49 38 60291 4963 42556043
Emotional distress 32.51 11.49 71 60258 16022 42544984
Muscle rigidity 32.51 11.49 60 60269 11999 42549007
Drug abuser 32.42 11.49 32 60297 3499 42557507
Treatment failure 32.03 11.49 25 60304 62599 42498407
Congenital pulmonary artery anomaly 31.96 11.49 7 60322 12 42560994
Product use issue 31.83 11.49 37 60292 76714 42484292
Abdominal pain 31.78 11.49 150 60179 190321 42370685
Oral discharge 31.74 11.49 11 60318 152 42560854
Neutropenia 31.57 11.49 160 60169 199271 42361735
Logorrhoea 30.65 11.49 28 60301 2779 42558227
Hypospadias 30.31 11.49 31 60298 3536 42557470
Congenital scoliosis 30.29 11.49 10 60319 118 42560888
Paraesthesia 29.19 11.49 191 60138 73268 42487738
Resting tremor 29.17 11.49 18 60311 983 42560023
Epistaxis 29.04 11.49 31 60298 66795 42494211
Pruritus 29.00 11.49 153 60176 188618 42372388
Hyperarousal 29.00 11.49 8 60321 48 42560958
Congenital genitourinary abnormality 28.86 11.49 8 60321 49 42560957
Alcohol interaction 28.76 11.49 24 60305 2111 42558895
Myoclonus 28.65 11.49 70 60259 16995 42544011
Multiple cardiac defects 28.58 11.49 8 60321 51 42560955
Ascites 28.52 11.49 23 60306 56655 42504351
Selective eating disorder 28.37 11.49 22 60307 1742 42559264
Hallucination, auditory 28.25 11.49 64 60265 14800 42546206
Congenital coronary artery malformation 28.19 11.49 8 60321 54 42560952
C-reactive protein increased 28.17 11.49 29 60300 63531 42497475
Congenital mitral valve stenosis 27.81 11.49 5 60324 0 42561006
Ebstein's anomaly 27.81 11.49 5 60324 0 42561006
Exhibitionism 27.70 11.49 8 60321 58 42560948
Dyskinesia 27.67 11.49 89 60240 25301 42535705
Patient elopement 27.57 11.49 10 60319 159 42560847
Cytomegalovirus infection 27.56 11.49 6 60323 32300 42528706
Cleft lip 27.49 11.49 12 60317 316 42560690
Verbal abuse 27.37 11.49 11 60318 234 42560772
Drug use disorder 27.34 11.49 51 60278 10282 42550724
Peripheral swelling 27.31 11.49 54 60275 90216 42470790
Blood creatine phosphokinase increased 27.28 11.49 138 60191 48200 42512806
Bradykinesia 27.25 11.49 36 60293 5400 42555606
Dependence 27.22 11.49 20 60309 1460 42559546
Developmental hip dysplasia 27.04 11.49 12 60317 329 42560677
Ejaculation failure 26.77 11.49 16 60313 825 42560181
Personality disorder 26.70 11.49 18 60311 1145 42559861
Pulmonary valve incompetence 26.70 11.49 18 60311 1145 42559861
Sleep apnoea syndrome 26.57 11.49 79 60250 21529 42539477
Delusion 26.42 11.49 62 60267 14672 42546334
Vascular stenosis 26.38 11.49 10 60319 181 42560825
Cerebral haematoma 26.36 11.49 36 60293 5574 42555432
Mucosal inflammation 26.16 11.49 19 60310 49355 42511651
Cardio-respiratory arrest 25.49 11.49 156 60173 58480 42502526
Loss of personal independence in daily activities 25.33 11.49 20 60309 49796 42511210
Subgaleal haematoma 25.16 11.49 8 60321 83 42560923
Neuropathy peripheral 25.12 11.49 68 60261 101785 42459221
Congenital hand malformation 24.96 11.49 14 60315 640 42560366
Urticarial vasculitis 24.91 11.49 8 60321 86 42560920
Aortic valve incompetence 24.89 11.49 38 60291 6510 42554496
Neural tube defect 24.57 11.49 7 60322 48 42560958
Vertigo 24.49 11.49 105 60224 34242 42526764
Pulmonary artery stenosis 24.38 11.49 11 60318 314 42560692
Blepharospasm 24.07 11.49 18 60311 1350 42559656
Paranoia 24.05 11.49 58 60271 13968 42547038
Erythema 23.67 11.49 77 60252 108716 42452290
Truncus arteriosus persistent 23.55 11.49 6 60323 25 42560981
Antipsychotic drug level increased 23.54 11.49 31 60298 4635 42556371
Mucosal prolapse syndrome 23.44 11.49 5 60324 7 42560999
Thrombosis 23.40 11.49 38 60291 68473 42492533
Congenital diaphragmatic hernia 23.39 11.49 10 60319 250 42560756
Administration related reaction 23.29 11.49 9 60320 172 42560834
Judgement impaired 23.26 11.49 13 60316 590 42560416
Seizure 23.25 11.49 267 60062 120294 42440712
Hallucination, visual 23.19 11.49 74 60255 20946 42540060
Dystonia 23.13 11.49 54 60275 12736 42548270
Emotional disorder 23.10 11.49 36 60293 6278 42554728
Bronchopulmonary dysplasia 23.05 11.49 14 60315 743 42560263
Accidental death 23.01 11.49 25 60304 3058 42557948
Haemoptysis 22.90 11.49 19 60310 46148 42514858
Congenital tracheomalacia 22.67 11.49 5 60324 9 42560997
Platelet count decreased 22.59 11.49 110 60219 138471 42422535
Congenital hydronephrosis 22.39 11.49 14 60315 783 42560223
Anorgasmia 22.36 11.49 16 60313 1121 42559885
Cardiac failure 22.31 11.49 77 60252 106779 42454227
Cardiomegaly 22.25 11.49 63 60266 16703 42544303
Aspermia 22.25 11.49 4 60325 0 42561006
Abdominal transposition 22.25 11.49 4 60325 0 42561006
Noonan syndrome 22.25 11.49 4 60325 0 42561006
Mitral valve atresia 22.25 11.49 4 60325 0 42561006
Idiosyncratic alcohol intoxication 22.25 11.49 4 60325 0 42561006
Self esteem decreased 22.19 11.49 12 60317 510 42560496
Joint swelling 22.07 11.49 39 60290 67983 42493023
Labelled drug-drug interaction issue 21.99 11.49 19 60310 1752 42559254
Depersonalisation/derealisation disorder 21.95 11.49 13 60316 659 42560347
Anaphylactic reaction 21.94 11.49 17 60312 42726 42518280
Autism spectrum disorder 21.90 11.49 24 60305 2964 42558042
Neutrophil count decreased 21.82 11.49 35 60294 63380 42497626
Decreased interest 21.79 11.49 23 60306 2722 42558284
Enuresis 21.77 11.49 23 60306 2725 42558281
Respiratory acidosis 21.65 11.49 35 60294 6296 42554710
Lower respiratory tract infection 21.65 11.49 16 60313 41190 42519816
Spina bifida 21.59 11.49 11 60318 413 42560593
Dysmorphism 21.51 11.49 25 60304 3291 42557715
Illusion 21.44 11.49 15 60314 1014 42559992
Prostate cancer 21.37 11.49 19 60310 44624 42516382
Miosis 21.36 11.49 54 60275 13392 42547614
Loss of consciousness 21.28 11.49 212 60117 92142 42468864
Ventricular hypertrophy 21.28 11.49 30 60299 4786 42556220
Agitation neonatal 21.22 11.49 17 60312 1411 42559595
Arthralgia 21.22 11.49 187 60142 205051 42355955
Ejaculation disorder 21.19 11.49 15 60314 1033 42559973
Tonic convulsion 21.01 11.49 18 60311 1641 42559365
Congenital pulmonary hypertension 20.87 11.49 7 60322 87 42560919
Theft 20.80 11.49 9 60320 232 42560774
Reversible cerebral vasoconstriction syndrome 20.79 11.49 13 60316 727 42560279
Neonatal asphyxia 20.40 11.49 11 60318 465 42560541
Epilepsy 20.22 11.49 82 60247 26089 42534917
Wolff-Parkinson-White syndrome 20.21 11.49 9 60320 249 42560757
Tension 20.19 11.49 21 60308 2443 42558563
Swelling 20.13 11.49 29 60300 54856 42506150
Infantile apnoea 20.11 11.49 15 60314 1121 42559885
Congenital flat feet 20.01 11.49 4 60325 3 42561003
Neoplasm progression 19.98 11.49 8 60321 28992 42532014
Congenital hydrocephalus 19.87 11.49 8 60321 171 42560835
Scaphocephaly 19.83 11.49 6 60323 52 42560954
Incorrect route of product administration 19.77 11.49 5 60324 24300 42536706
Gastroschisis 19.70 11.49 8 60321 175 42560831
Neurosis 19.70 11.49 8 60321 175 42560831
Intention tremor 19.68 11.49 11 60318 499 42560507
Infusion related reaction 19.60 11.49 35 60294 60771 42500235
Product dose omission issue 19.53 11.49 133 60196 154232 42406774
Psychomotor hyperactivity 19.53 11.49 46 60283 10912 42550094
Inappropriate schedule of product administration 19.42 11.49 70 60259 95832 42465174
Transient tachypnoea of the newborn 19.37 11.49 8 60321 183 42560823
Cerebrovascular stenosis 19.20 11.49 7 60322 113 42560893
Caesarean section 19.18 11.49 19 60310 2087 42558919
Mood altered 19.11 11.49 45 60284 10673 42550333
Psychotic disorder 19.09 11.49 87 60242 29121 42531885
Mitral valve incompetence 19.07 11.49 59 60270 16430 42544576
Premature baby 19.06 11.49 74 60255 23079 42537927
Nightmare 19.03 11.49 78 60251 24934 42536072
Sedation complication 18.93 11.49 22 60307 2897 42558109
Flat affect 18.92 11.49 14 60315 1033 42559973
Inadequate analgesia 18.92 11.49 23 60306 3174 42557832
Clumsiness 18.91 11.49 18 60311 1882 42559124
Hyponatraemia 18.80 11.49 223 60106 101239 42459767
Hospitalisation 18.79 11.49 49 60280 74281 42486725
Crying 18.75 11.49 33 60296 6361 42554645
Abnormal dreams 18.45 11.49 38 60291 8233 42552773
Haemoglobin decreased 18.36 11.49 111 60218 132360 42428646
White blood cell count decreased 18.35 11.49 87 60242 110309 42450697
Renal dysplasia 18.18 11.49 8 60321 215 42560791
Psychiatric symptom 18.12 11.49 26 60303 4215 42556791
Cytogenetic abnormality 18.08 11.49 13 60316 918 42560088
Hypersensitivity 18.08 11.49 48 60281 72322 42488684
Legal problem 18.01 11.49 7 60322 136 42560870
Cryptorchism 17.93 11.49 18 60311 2009 42558997
Plasmodium vivax infection 17.86 11.49 4 60325 8 42560998
Transvestism 17.86 11.49 4 60325 8 42560998
Speech disorder 17.75 11.49 85 60244 29036 42531970
Tricuspid valve disease 17.74 11.49 8 60321 228 42560778
Colitis 17.69 11.49 24 60305 46548 42514458
Motor dysfunction 17.68 11.49 37 60292 8109 42552897
Plasma cell myeloma 17.59 11.49 25 60304 47553 42513453
Chemical submission 17.58 11.49 6 60323 79 42560927
Libido increased 17.50 11.49 13 60316 965 42560041
Fear 17.38 11.49 44 60285 10921 42550085
Chordee 17.37 11.49 6 60323 82 42560924
Tearfulness 17.27 11.49 23 60306 3477 42557529
Euphoric mood 17.26 11.49 32 60297 6421 42554585
Fall 17.19 11.49 444 59885 234076 42326930
Pleurothotonus 17.12 11.49 14 60315 1197 42559809
Somatic dysfunction 17.10 11.49 5 60324 38 42560968
Product administration error 17.08 11.49 61 60268 18282 42542724
Eating disorder 17.08 11.49 41 60288 9844 42551162
Pulmonary hypoplasia 16.94 11.49 10 60319 504 42560502
Tardive dyskinesia 16.87 11.49 33 60296 6891 42554115
Abdominal distension 16.86 11.49 49 60280 71686 42489320
Oedema peripheral 16.84 11.49 118 60211 135958 42425048
Type 2 diabetes mellitus 16.84 11.49 61 60268 18410 42542596
Derealisation 16.74 11.49 12 60317 843 42560163
Obsessive thoughts 16.70 11.49 12 60317 846 42560160
Porencephaly 16.69 11.49 3 60326 0 42561006
Congenital pulmonary valve disorder 16.69 11.49 3 60326 0 42561006
Congenital Eustachian tube anomaly 16.69 11.49 3 60326 0 42561006
Ammonia abnormal 16.68 11.49 6 60323 93 42560913
Abulia 16.61 11.49 11 60318 679 42560327
Pain in extremity 16.55 11.49 135 60194 150469 42410537
Mitral valve prolapse 16.51 11.49 11 60318 686 42560320
Excessive sexual fantasies 16.48 11.49 4 60325 13 42560993
Panic disorder 16.47 11.49 14 60315 1263 42559743
Loss of libido 16.43 11.49 21 60308 3049 42557957
Productive cough 16.33 11.49 30 60299 51537 42509469
Injection site pain 16.28 11.49 36 60293 57762 42503244
Substance use disorder 16.21 11.49 28 60301 5317 42555689
Incoherent 16.16 11.49 26 60303 4659 42556347
Drug intolerance 16.09 11.49 59 60270 80365 42480641
Perinatal stroke 16.07 11.49 5 60324 48 42560958
Infertility male 16.01 11.49 7 60322 185 42560821
Pain 16.00 11.49 247 60082 244601 42316405
No adverse event 15.97 11.49 19 60310 39002 42522004
Oesophageal disorder 15.87 11.49 14 60315 1328 42559678
Bronchopulmonary aspergillosis 15.79 11.49 4 60325 19425 42541581
Congenital renal disorder 15.76 11.49 6 60323 110 42560896
Hypophosphataemia 15.75 11.49 5 60324 20940 42540066
Pneumocystis jirovecii pneumonia 15.70 11.49 8 60321 25173 42535833
Hepatotoxicity 15.68 11.49 8 60321 25159 42535847
Antisocial behaviour 15.68 11.49 9 60320 430 42560576
Hyperkinesia 15.63 11.49 17 60312 2081 42558925
Leukopenia 15.50 11.49 54 60275 74692 42486314
Vesicoureteric reflux 15.44 11.49 7 60322 202 42560804
Cytopenia 15.44 11.49 3 60326 17494 42543512
Appendicitis 15.36 11.49 5 60324 20608 42540398
Palmar-plantar erythrodysaesthesia syndrome 15.33 11.49 5 60324 20577 42540429
Exomphalos 15.19 11.49 7 60322 210 42560796
Product complaint 15.19 11.49 29 60300 5948 42555058
Opisthotonus 15.01 11.49 10 60319 624 42560382
Cyclothymic disorder 14.83 11.49 6 60323 130 42560876
Reflux laryngitis 14.83 11.49 6 60323 130 42560876
Injection site swelling 14.79 11.49 3 60326 16970 42544036
Hallucination 14.72 11.49 135 60194 57372 42503634
Oculoauriculovertebral dysplasia 14.61 11.49 3 60326 3 42561003
Congenital mitral valve incompetence 14.54 11.49 6 60323 137 42560869
Chronic kidney disease 14.51 11.49 28 60301 47213 42513793
Basal cell carcinoma 14.51 11.49 7 60322 22726 42538280
Drug ineffective for unapproved indication 14.49 11.49 27 60302 46136 42514870
Respiratory distress 14.39 11.49 105 60224 41715 42519291
Urinary tract infection 14.39 11.49 82 60247 99202 42461804
Hepatocellular injury 14.35 11.49 69 60260 23609 42537397
Drug screen positive 14.35 11.49 23 60306 4108 42556898
End stage renal disease 14.27 11.49 3 60326 16555 42544451
Feeling guilty 14.25 11.49 8 60321 366 42560640
Hypocalcaemia 14.25 11.49 13 60316 30160 42530846
Skin exfoliation 14.23 11.49 23 60306 41530 42519476
Feeling jittery 14.22 11.49 24 60305 4474 42556532
Ankyloglossia congenital 14.17 11.49 8 60321 370 42560636
Apnoea 14.17 11.49 33 60296 7770 42553236
Ulcer 14.13 11.49 3 60326 16438 42544568
Respiratory tract infection 14.11 11.49 10 60319 26312 42534694
Congenital tricuspid valve incompetence 14.11 11.49 6 60323 148 42560858
Glomerular filtration rate decreased 14.02 11.49 3 60326 16348 42544658
Renal failure 13.95 11.49 133 60196 143593 42417413
Pancreas infection 13.94 11.49 8 60321 382 42560624
Obsessive-compulsive disorder 13.91 11.49 30 60299 6713 42554293
Sedation 13.82 11.49 82 60247 30393 42530613
Sexually transmitted disease 13.73 11.49 4 60325 30 42560976
Pyloric stenosis 13.69 11.49 11 60318 917 42560089
Microcephaly 13.63 11.49 11 60318 923 42560083
Multiple organ dysfunction syndrome 13.60 11.49 81 60248 96954 42464052
Asplenia 13.48 11.49 5 60324 85 42560921
Confusional arousal 13.29 11.49 4 60325 34 42560972
Myocardial bridging 13.29 11.49 4 60325 34 42560972
COVID-19 pneumonia 13.27 11.49 7 60322 21606 42539400
Foetal macrosomia 13.21 11.49 6 60323 174 42560832
Eyelid ptosis congenital 13.11 11.49 5 60324 92 42560914
Failure to thrive 13.09 11.49 36 60293 9386 42551620
Acute pulmonary oedema 12.97 11.49 34 60295 8617 42552389
Gastrointestinal haemorrhage 12.96 11.49 83 60246 97643 42463363
Neonatal disorder 12.84 11.49 10 60319 797 42560209
Blood creatinine increased 12.83 11.49 97 60232 109906 42451100
Brachycephaly 12.82 11.49 5 60324 98 42560908
Vasculitis 12.79 11.49 5 60324 18389 42542617
Hydrocele 12.78 11.49 17 60312 2566 42558440
Clonus 12.78 11.49 20 60309 3500 42557506
Feeling abnormal 12.75 11.49 153 60176 69633 42491373
Personal relationship issue 12.74 11.49 7 60322 307 42560699
Mitral valve disease 12.61 11.49 13 60316 1497 42559509
Gallbladder injury 12.61 11.49 6 60323 194 42560812
Acute myeloid leukaemia 12.54 11.49 8 60321 22248 42538758
Hepatic enzyme increased 12.50 11.49 29 60300 45755 42515251
Electrocardiogram QT prolonged 12.50 11.49 113 60216 47832 42513174
Cognitive disorder 12.45 11.49 87 60242 34085 42526921
Waxy flexibility 12.42 11.49 5 60324 107 42560899
Transcription medication error 12.38 11.49 7 60322 325 42560681
Aorta hypoplasia 12.29 11.49 5 60324 110 42560896
Nystagmus 12.28 11.49 25 60304 5371 42555635
Major depression 12.28 11.49 25 60304 5373 42555633
Genital paraesthesia 12.21 11.49 4 60325 46 42560960
Limb asymmetry 12.20 11.49 5 60324 112 42560894
Impulse-control disorder 12.15 11.49 13 60316 1562 42559444
Dry skin 12.11 11.49 32 60297 48306 42512700
Stomatitis 12.10 11.49 34 60295 50295 42510711
Otitis media chronic 12.08 11.49 5 60324 115 42560891
Divorced 12.08 11.49 3 60326 11 42560995
Bacterial infection 12.03 11.49 13 60316 27866 42533140
Ventricular tachycardia 12.01 11.49 15 60314 30145 42530861
Herpes zoster 11.97 11.49 23 60306 38854 42522152
Haematoma muscle 11.97 11.49 15 60314 2135 42558871
Feeling of relaxation 11.91 11.49 4 60325 50 42560956
Intentional product misuse 11.88 11.49 137 60192 61763 42499243
Congenital brain damage 11.87 11.49 3 60326 12 42560994
Right ventricle outflow tract obstruction 11.84 11.49 4 60325 51 42560955
Jaundice neonatal 11.81 11.49 15 60314 2164 42558842
Cellulitis 11.78 11.49 46 60283 61539 42499467
Head injury 11.78 11.49 59 60270 20523 42540483
Wheezing 11.75 11.49 39 60290 54742 42506264
Neutropenic sepsis 11.65 11.49 4 60325 15942 42545064
Subdural haematoma 11.64 11.49 64 60265 23074 42537932
Negative thoughts 11.60 11.49 9 60320 713 42560293
Pneumonia staphylococcal 11.59 11.49 19 60310 3457 42557549
Housebound 11.59 11.49 6 60323 233 42560773
Apathy 11.56 11.49 32 60297 8374 42552632
Eczema 11.55 11.49 19 60310 34067 42526939
Liver function test increased 11.53 11.49 7 60322 19991 42541015
Colitis ulcerative 11.53 11.49 12 60317 26163 42534843
Syndactyly 11.51 11.49 10 60319 929 42560077

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 1430.16 9.70 925 147134 58228 110383012
Drug abuse 885.26 9.70 1138 146921 176273 110264967
Drug withdrawal syndrome 880.16 9.70 579 147480 37475 110403765
Suicide attempt 812.86 9.70 839 147220 102555 110338685
Suicidal ideation 809.32 9.70 801 147258 93136 110348104
Sopor 688.57 9.70 490 147569 36056 110405184
Drug interaction 542.08 9.70 1684 146375 498499 109942741
Completed suicide 495.17 9.70 1038 147021 241343 110199897
Agitation 487.97 9.70 676 147383 112375 110328865
Poisoning deliberate 470.69 9.70 342 147717 25989 110415251
Tremor 423.38 9.70 875 147184 201357 110239883
Somnolence 406.37 9.70 1089 146970 296360 110144880
Anxiety 399.71 9.70 1190 146869 343888 110097352
Toxicity to various agents 367.32 9.70 1442 146617 479113 109962127
Intentional self-injury 361.40 9.70 340 147719 37089 110404151
Mydriasis 347.34 9.70 266 147793 21891 110419349
Coma 297.54 9.70 552 147507 117317 110323923
Aggression 295.15 9.70 380 147679 58830 110382410
Irritability 290.38 9.70 339 147720 47470 110393770
Mania 277.31 9.70 227 147832 20569 110420671
Neuroleptic malignant syndrome 272.14 9.70 279 147780 33780 110407460
Hyponatraemia 254.00 9.70 753 147306 216900 110224340
Off label use 251.46 9.70 1096 146963 1499089 108942151
Intentional overdose 250.21 9.70 550 147509 131951 110309289
Disorientation 234.92 9.70 374 147685 70297 110370943
Withdrawal syndrome 216.91 9.70 238 147821 31142 110410098
Hand deformity 216.47 9.70 21 148038 218485 110222755
Panic attack 213.19 9.70 227 147832 28713 110412527
Overdose 202.62 9.70 731 147328 233063 110208177
Depersonalisation/derealisation disorder 201.12 9.70 84 147975 2097 110439143
Disturbance in attention 197.73 9.70 322 147737 61673 110379567
Extrapyramidal disorder 196.17 9.70 217 147842 28650 110412590
Inappropriate antidiuretic hormone secretion 195.57 9.70 234 147825 33617 110407623
Nightmare 194.57 9.70 250 147809 38613 110402627
Confusional state 193.76 9.70 1180 146879 467500 109973740
Hallucinations, mixed 188.20 9.70 127 147932 8566 110432674
Systemic lupus erythematosus 185.52 9.70 55 148004 254283 110186957
Glossodynia 183.36 9.70 37 148022 221967 110219273
Pemphigus 183.08 9.70 33 148026 214537 110226703
Mood swings 177.06 9.70 184 147875 22628 110418612
Derealisation 172.15 9.70 75 147984 2083 110439157
Febrile neutropenia 168.71 9.70 108 147951 316659 110124581
Altered state of consciousness 162.11 9.70 283 147776 57343 110383897
Anti-cyclic citrullinated peptide antibody positive 161.88 9.70 25 148034 181959 110259281
Dyskinesia 161.07 9.70 265 147794 51181 110390059
Activation syndrome 157.23 9.70 45 148014 335 110440905
Bradyphrenia 154.23 9.70 127 147932 11601 110429639
Restlessness 154 9.70 273 147786 55986 110385254
Cogwheel rigidity 153.16 9.70 82 147977 3616 110437624
Helicobacter infection 152.95 9.70 29 148030 181848 110259392
Myoglobin urine present 151.39 9.70 54 148005 866 110440374
Pericarditis 149.86 9.70 53 148006 219061 110222179
Depression 149.23 9.70 827 147232 316508 110124732
Hyperhidrosis 149.16 9.70 570 147489 186728 110254512
Anger 148.76 9.70 154 147905 18853 110422387
Feeling of despair 145.57 9.70 80 147979 3718 110437522
Duodenal ulcer perforation 143.88 9.70 31 148028 177669 110263571
Drug dependence 143.77 9.70 248 147811 49772 110391468
Hallucination, auditory 143.58 9.70 177 147882 26220 110415020
Alopecia 143.57 9.70 166 147893 364587 110076653
Insomnia 138.35 9.70 891 147168 359699 110081541
Joint swelling 137.17 9.70 239 147820 442606 109998634
Impulsive behaviour 135.87 9.70 73 147986 3242 110437998
Homicide 134.54 9.70 52 148007 1054 110440186
Infusion related reaction 133.93 9.70 189 147870 380973 110060267
Swelling 133.63 9.70 164 147895 350877 110090363
Gastric pH decreased 123.78 9.70 48 148011 982 110440258
Emotional disorder 121.22 9.70 128 147931 16032 110425208
Hyperreflexia 121.16 9.70 101 147958 9384 110431856
Folliculitis 120.87 9.70 37 148022 167616 110273624
Contraindicated product administered 119.86 9.70 94 147965 248173 110193067
Blister 116.35 9.70 81 147978 227295 110213945
Rash 109.96 9.70 647 147412 820317 109620923
Hallucination, visual 109.44 9.70 193 147866 39412 110401828
Dissociation 107.85 9.70 96 147963 9746 110431494
Intentional product use issue 107.39 9.70 104 147955 247802 110193438
Drug intolerance 107.24 9.70 241 147818 406271 110034969
Parkinsonism 106.79 9.70 140 147919 22047 110419193
Akathisia 106.65 9.70 123 147936 16990 110424250
Stomatitis 106.29 9.70 123 147936 270119 110171121
C-reactive protein abnormal 106.27 9.70 22 148037 129673 110311567
Depressed level of consciousness 105.75 9.70 361 147698 111917 110329323
Wound 105.50 9.70 95 147964 234342 110206898
Synovitis 105.40 9.70 127 147932 273965 110167275
Muscle injury 105.32 9.70 29 148030 140778 110300462
Myelosuppression 105.21 9.70 5 148054 94335 110346905
Delirium 104.25 9.70 407 147652 134618 110306622
Cardio-respiratory arrest 102.65 9.70 365 147694 115471 110325769
Sleep disorder due to general medical condition, insomnia type 102.40 9.70 11 148048 105632 110335608
Psoriatic arthropathy 102.12 9.70 69 147990 196692 110244548
Myoclonus 101.97 9.70 169 147890 32829 110408411
Lower respiratory tract infection 101.85 9.70 105 147954 243001 110198239
Mobility decreased 101.23 9.70 101 147958 237321 110203919
Nervousness 99.79 9.70 178 147881 36673 110404567
Muscle rigidity 99.56 9.70 141 147918 23890 110417350
Vertigo 98.80 9.70 298 147761 86572 110354668
Drug ineffective 96.66 9.70 1445 146614 1519095 108922145
Agoraphobia 95.49 9.70 36 148023 680 110440560
Abnormal behaviour 94.91 9.70 180 147879 38859 110402381
Nasopharyngitis 94.37 9.70 246 147813 394115 110047125
Hypersensitivity 93.66 9.70 256 147803 403742 110037498
Blood creatine phosphokinase increased 93.03 9.70 261 147798 72816 110368424
Irritable bowel syndrome 92.98 9.70 52 148007 164163 110277077
Fall 92.54 9.70 1223 146836 602259 109838981
Delusion 92.01 9.70 135 147924 23620 110417620
Loss of consciousness 90.47 9.70 509 147550 195797 110245443
Hepatic enzyme increased 89.80 9.70 184 147875 320708 110120532
Rhabdomyolysis 88.98 9.70 358 147701 120043 110321197
General physical health deterioration 88.82 9.70 283 147776 425012 110016228
Flat affect 88.46 9.70 50 148009 2455 110438785
Libido increased 87.83 9.70 50 148009 2489 110438751
COVID-19 87.54 9.70 120 147939 244940 110196300
Abdominal discomfort 87.29 9.70 255 147804 393603 110047637
Hallucination 86.79 9.70 316 147743 101116 110340124
Speech disorder 86.47 9.70 228 147831 61341 110379899
Homicidal ideation 85.79 9.70 56 148003 3571 110437669
Dystonia 84.94 9.70 136 147923 25669 110415571
Joint range of motion decreased 84.09 9.70 29 148030 121803 110319437
Pneumonia 84.01 9.70 760 147299 875954 109565286
Bronchial neoplasm 82.71 9.70 30 148029 506 110440734
Electrocardiogram QT prolonged 82.13 9.70 326 147733 108634 110332606
Fibromyalgia 82.10 9.70 65 147994 170844 110270396
Disease progression 81.76 9.70 125 147934 243909 110197331
Crying 81.54 9.70 133 147926 25495 110415745
Psychotic disorder 80.23 9.70 197 147862 50740 110390500
Clonus 78.09 9.70 76 147983 8640 110432600
Poisoning 76.78 9.70 139 147920 28966 110412274
Treatment failure 76.68 9.70 160 147899 277074 110164166
Discomfort 75.82 9.70 106 147953 214601 110226639
Depressed mood 75.26 9.70 215 147844 60594 110380646
Emotional distress 74.44 9.70 177 147882 44670 110396570
Feeling jittery 74.14 9.70 95 147964 14627 110426613
Rheumatic fever 73.55 9.70 36 148023 122543 110318697
Restless legs syndrome 73.26 9.70 124 147935 24502 110416738
Abnormal dreams 73.24 9.70 88 147971 12692 110428548
Sepsis 73.20 9.70 211 147848 327135 110114105
Infection 72.85 9.70 245 147814 361955 110079285
Gastrointestinal disorder 72.66 9.70 133 147926 241819 110199421
Seizure 72.50 9.70 526 147533 220659 110220581
H1N1 influenza 72.37 9.70 47 148012 2971 110438269
Cough 71.58 9.70 346 147713 461295 109979945
Malignant neoplasm progression 71.30 9.70 77 147982 174490 110266750
Affective disorder 70.40 9.70 81 147978 11160 110430080
Peripheral swelling 69.73 9.70 291 147768 403743 110037497
Libido decreased 69.26 9.70 60 147999 5875 110435365
Tearfulness 69.12 9.70 66 147993 7329 110433911
Sexual dysfunction 68.35 9.70 70 147989 8460 110432780
Impaired healing 67.60 9.70 99 147960 196618 110244622
Menstrual disorder 67.54 9.70 54 148005 4730 110436510
Asphyxia 67.34 9.70 89 147970 14126 110427114
Feeling of body temperature change 67.09 9.70 60 147999 6128 110435112
Sinus tachycardia 66.84 9.70 169 147890 44324 110396916
Arthropathy 66.75 9.70 182 147877 287340 110153900
Nasal turbinate hypertrophy 66.24 9.70 29 148030 815 110440425
Endometrial ablation 66.16 9.70 30 148029 918 110440322
Drooling 65.37 9.70 63 147996 7076 110434164
Hyperprolactinaemia 63.97 9.70 60 147999 6515 110434725
Product use issue 63.93 9.70 209 147850 311486 110129754
Encephalopathy 63.91 9.70 246 147813 80809 110360431
Hepatocellular injury 63.59 9.70 180 147879 50462 110390778
Bursitis 62.91 9.70 49 148010 129869 110311371
Rheumatoid arthritis 62.77 9.70 199 147860 299414 110141826
Erectile dysfunction 62.73 9.70 99 147960 18457 110422783
Facet joint syndrome 61.90 9.70 26 148033 96802 110344438
Fear 60.21 9.70 110 147949 23083 110418157
Wheezing 59.66 9.70 161 147898 255069 110186171
Breath sounds abnormal 59.13 9.70 115 147944 25289 110415951
Pyrexia 58.07 9.70 850 147209 897415 109543825
Lip dry 57.65 9.70 31 148028 100052 110341188
Hypertonia 56.77 9.70 63 147996 8343 110432897
Urinary retention 56.18 9.70 213 147846 69470 110371770
Muscle disorder 55.74 9.70 56 148003 6616 110434624
Oedema 55.71 9.70 124 147935 209852 110231388
Liver injury 55.38 9.70 72 147987 150341 110290899
Bradykinesia 54.93 9.70 70 147989 10718 110430522
Congenital hydrocephalus 53.99 9.70 14 148045 68 110441172
Therapeutic product ineffective 53.89 9.70 37 148022 2567 110438673
Grip strength decreased 53.76 9.70 20 148039 80154 110361086
Logorrhoea 53.62 9.70 48 148011 4909 110436331
Hostility 52.73 9.70 37 148022 2659 110438581
Bronchial haemorrhage 52.56 9.70 29 148030 1358 110439882
Psychomotor hyperactivity 52.42 9.70 96 147963 20181 110421059
Paranoia 51.73 9.70 101 147958 22273 110418967
Tachycardia 51.30 9.70 496 147563 226149 110215091
Musculoskeletal pain 51.12 9.70 105 147954 182918 110258322
Galactorrhoea 50.51 9.70 43 148016 4112 110437128
Dyspnoea 50.46 9.70 1114 146945 1105758 109335482
Memory impairment 50.12 9.70 442 147617 196502 110244738
Thinking abnormal 50.11 9.70 80 147979 15060 110426180
Gun shot wound 49.86 9.70 26 148033 1086 110440154
Reversible cerebral vasoconstriction syndrome 49.33 9.70 45 148014 4716 110436524
Substance abuse 48.51 9.70 71 147988 12392 110428848
Drug abuser 48.15 9.70 47 148012 5362 110435878
Swollen joint count increased 48.06 9.70 26 148033 83635 110357605
Hyperthermia 47.94 9.70 95 147964 21177 110420063
Self esteem decreased 47.77 9.70 25 148034 1052 110440188
Cytomegalovirus infection 47.23 9.70 8 148051 54436 110386804
Hypomania 46.94 9.70 63 147996 10147 110431093
Bipolar disorder 46.74 9.70 59 148000 8948 110432292
Pain 46.74 9.70 950 147109 954005 109487235
Neutrophil count decreased 46.50 9.70 56 148003 120885 110320355
Apathy 45.98 9.70 80 147979 16159 110425081
Therapeutic product effect decreased 45.92 9.70 170 147889 244146 110197094
Incontinence 45.87 9.70 81 147978 16554 110424686
Toxic encephalopathy 45.77 9.70 77 147982 15137 110426103
Sinusitis 45.00 9.70 224 147835 296464 110144776
Breast cancer stage III 44.85 9.70 25 148034 79092 110362148
Arthralgia 44.53 9.70 755 147304 778877 109662363
Euphoric mood 44.51 9.70 57 148002 8770 110432470
Cognitive disorder 44.39 9.70 233 147826 87278 110353962
Premature labour 44.33 9.70 58 148001 9114 110432126
Muscle twitching 44.23 9.70 113 147946 29822 110411418
Dependence 43.28 9.70 33 148026 2696 110438544
Physical assault 43.13 9.70 27 148032 1601 110439639
PCO2 increased 43.07 9.70 29 148030 1948 110439292
Anorgasmia 42.86 9.70 27 148032 1619 110439621
Neuropathy peripheral 42.71 9.70 112 147947 179165 110262075
Amylase increased 42.61 9.70 67 147992 12452 110428788
Alloimmunisation 42.13 9.70 9 148050 14 110441226
Pancytopenia 41.97 9.70 142 147917 209471 110231769
Urticaria 41.64 9.70 253 147806 318604 110122636
Hangover 41.33 9.70 31 148028 2471 110438769
Bradycardia 41.11 9.70 352 147707 155165 110286075
Lung disorder 40.26 9.70 116 147943 179931 110261309
Cytokine release syndrome 40.17 9.70 22 148037 70284 110370956
Tinnitus 40.01 9.70 174 147885 60366 110380874
Visceral congestion 39.96 9.70 24 148035 1321 110439919
Apraxia 39.72 9.70 35 148024 3505 110437735
Soft tissue injury 39.39 9.70 29 148030 2247 110438993
Peripheral venous disease 39.13 9.70 33 148026 84084 110357156
Mood altered 38.36 9.70 87 147972 21288 110419952
Wound infection 37.80 9.70 44 148015 96421 110344819
Major depression 37.76 9.70 58 148001 10563 110430677
Cerebral haematoma 37.68 9.70 55 148004 9577 110431663
Ejaculation delayed 37.55 9.70 13 148046 190 110441050
Ill-defined disorder 37.35 9.70 98 147961 156755 110284485
Hypoaesthesia oral 37.20 9.70 75 147984 16927 110424313
Accidental poisoning 37.10 9.70 29 148030 2458 110438782
Affect lability 37.01 9.70 79 147980 18558 110422682
Hyperacusis 36.81 9.70 31 148028 2921 110438319
Mucosal inflammation 36.45 9.70 45 148014 96096 110345144
Respiratory acidosis 36.43 9.70 66 147993 13760 110427480
Bronchial disorder 36.37 9.70 30 148029 2746 110438494
Rhonchi 36.06 9.70 37 148022 4481 110436759
Coeliac disease 36.05 9.70 7 148052 43180 110398060
Dysarthria 36.03 9.70 214 147845 83907 110357333
Product complaint 35.93 9.70 66 147993 13906 110427334
Anticholinergic syndrome 35.89 9.70 36 148023 4244 110436996
Balance disorder 35.78 9.70 273 147786 116287 110324953
Disorganised speech 35.76 9.70 32 148027 3271 110437969
Lower limb fracture 35.74 9.70 29 148030 75319 110365921
Thrombocytopenia 35.71 9.70 297 147762 348588 110092652
Loss of libido 35.20 9.70 31 148028 3102 110438138
Granuloma skin 35.14 9.70 58 148001 11225 110430015
Septic shock 34.85 9.70 102 147957 157426 110283814
Verbal abuse 34.66 9.70 14 148045 320 110440920
Paralysis 34.35 9.70 69 147990 15531 110425709
Generalised anxiety disorder 34.27 9.70 29 148030 2750 110438490
Treatment noncompliance 34.08 9.70 190 147869 72800 110368440
Post-traumatic neck syndrome 33.91 9.70 28 148031 2567 110438673
Paraesthesia 33.78 9.70 539 147520 275982 110165258
Obsessive-compulsive disorder 33.78 9.70 45 148014 7196 110434044
Ascites 33.57 9.70 45 148014 92763 110348477
Alcohol abuse 33.39 9.70 37 148022 4892 110436348
Thermal burn 33.28 9.70 47 148012 7941 110433299
Chemical submission 33.19 9.70 16 148043 564 110440676
Product use in unapproved indication 32.55 9.70 413 147646 446964 109994276
Catatonia 32.43 9.70 56 148003 11244 110429996
Neutropenia 32.26 9.70 333 147726 374287 110066953
Injection site pain 32.01 9.70 126 147933 177796 110263444
Hepatotoxicity 31.86 9.70 23 148036 63377 110377863
Self-injurious ideation 31.84 9.70 34 148025 4312 110436928
Maternal exposure during pregnancy 31.84 9.70 205 147854 254678 110186562
Illusion 31.24 9.70 24 148035 1983 110439257
Personality disorder 30.96 9.70 59 148000 12778 110428462
Hypokinesia 30.81 9.70 81 147978 21745 110419495
Anaphylactic reaction 30.72 9.70 67 147992 114233 110327007
Increased appetite 30.34 9.70 64 147995 14913 110426327
Sciatica 30.28 9.70 48 148011 92351 110348889
Incoherent 30.22 9.70 46 148013 8312 110432928
Renal ischaemia 30.22 9.70 25 148034 2298 110438942
Dizziness 30.12 9.70 1181 146878 697012 109744228
Autoimmune disorder 30.08 9.70 26 148033 65457 110375783
Rheumatoid factor positive 30.02 9.70 84 147975 131556 110309684
Tardive dyskinesia 29.83 9.70 60 147999 13519 110427721
Schizophrenia 29.80 9.70 80 147979 21746 110419494
Panniculitis 29.74 9.70 65 147994 15517 110425723
Oral discharge 29.72 9.70 12 148047 274 110440966
Joint hyperextension 29.61 9.70 13 148046 368 110440872
Endocrine ophthalmopathy 29.58 9.70 20 148039 1353 110439887
PO2 increased 29.57 9.70 21 148038 1538 110439702
Vision blurred 29.49 9.70 283 147776 128739 110312501
Ejaculation failure 29.38 9.70 13 148046 375 110440865
Blood sodium decreased 29.14 9.70 115 147944 38204 110403036
Sedation 29.03 9.70 176 147883 69507 110371733
Blood parathyroid hormone decreased 28.95 9.70 58 148001 13031 110428209
Antidepressant discontinuation syndrome 28.83 9.70 10 148049 147 110441093
Panic disorder 28.82 9.70 29 148030 3432 110437808
Antipsychotic drug level increased 28.82 9.70 41 148018 6974 110434266
Negative thoughts 28.55 9.70 21 148038 1625 110439615
Hip arthroplasty 28.37 9.70 20 148039 55793 110385447
Pain in extremity 28.32 9.70 470 147589 486648 109954592
Electroencephalogram abnormal 28.24 9.70 38 148021 6135 110435105
Subdural haematoma 28.21 9.70 110 147949 36344 110404896
Violence-related symptom 28.20 9.70 17 148042 942 110440298
Social anxiety disorder 28.09 9.70 17 148042 949 110440291
Liver function test increased 28.08 9.70 47 148012 88501 110352739
Toxicologic test abnormal 28.06 9.70 19 148040 1288 110439952
Sternal fracture 28.01 9.70 28 148031 3288 110437952
Accidental death 27.90 9.70 34 148025 4975 110436265
Exhibitionism 27.90 9.70 8 148051 60 110441180
Frontotemporal dementia 27.88 9.70 15 148044 668 110440572
Nail disorder 27.85 9.70 22 148037 57913 110383327
Respiratory tract infection 27.70 9.70 33 148026 71584 110369656
Tension 27.53 9.70 34 148025 5044 110436196
Drug use disorder 27.51 9.70 69 147990 18005 110423235
Feeling abnormal 27.50 9.70 366 147693 180345 110260895
Colitis ulcerative 27.49 9.70 38 148021 77325 110363915
Miosis 27.46 9.70 78 147981 21905 110419335
Patient elopement 27.32 9.70 12 148047 340 110440900
Product dose omission issue 27.30 9.70 287 147772 321495 110119745
Bone erosion 27.24 9.70 14 148045 46357 110394883
Sensory disturbance 27.01 9.70 67 147992 17362 110423878
Metastases to liver 27.00 9.70 7 148052 35379 110405861
Coma scale 26.92 9.70 8 148051 69 110441171
Middle insomnia 26.85 9.70 74 147985 20428 110420812
Anaemia 26.76 9.70 544 147515 546542 109894698
Deep vein thrombosis postoperative 26.68 9.70 24 148035 59267 110381973
Lividity 26.58 9.70 14 148045 597 110440643
Atrial fibrillation 26.54 9.70 189 147870 229453 110211787
Blood pH decreased 26.51 9.70 32 148027 4637 110436603
Vulvovaginal burning sensation 26.36 9.70 22 148037 2047 110439193
Eye movement disorder 26.35 9.70 47 148012 9681 110431559
Parosmia 26.32 9.70 56 148003 13124 110428116
Knee arthroplasty 26.12 9.70 29 148030 64919 110376321
Social avoidant behaviour 26.02 9.70 34 148025 5335 110435905
C-reactive protein increased 25.84 9.70 178 147881 217741 110223499
Cyanosis 25.72 9.70 93 147966 29648 110411592
Obsessive thoughts 25.71 9.70 18 148041 1289 110439951
Neutropenic sepsis 25.63 9.70 5 148054 30741 110410499
Resting tremor 25.51 9.70 20 148039 1703 110439537
Urticaria thermal 25.49 9.70 13 148046 518 110440722
Alcoholism 25.41 9.70 28 148031 3679 110437561
Hyperarousal 25.21 9.70 7 148052 46 110441194
Hyper IgE syndrome 25.15 9.70 14 148045 667 110440573
Head titubation 25.10 9.70 18 148041 1339 110439901
Tonic clonic movements 25.07 9.70 25 148034 2927 110438313
Chorea 24.93 9.70 26 148033 3209 110438031
Intentional product misuse 24.92 9.70 280 147779 132624 110308616
Osteoarthritis 24.83 9.70 143 147916 182480 110258760
Live birth 24.82 9.70 34 148025 69450 110371790
Victim of crime 24.79 9.70 18 148041 1365 110439875
Administration site erythema 24.79 9.70 12 148047 427 110440813
Liver disorder 24.78 9.70 102 147957 142141 110299099
Adjustment disorder with depressed mood 24.68 9.70 14 148045 43869 110397371
Creutzfeldt-Jakob disease 24.66 9.70 10 148049 231 110441009
Anhedonia 24.64 9.70 60 147999 15368 110425872
Soliloquy 24.64 9.70 16 148043 1011 110440229
Haemorrhagic stroke 24.61 9.70 56 148003 13733 110427507
Dislocation of vertebra 24.51 9.70 14 148045 43707 110397533
Finger deformity 24.39 9.70 7 148052 33085 110408155
Inadequate analgesia 24.38 9.70 32 148027 5045 110436195
Respiratory depression 24.31 9.70 96 147963 31905 110409335
Upper respiratory tract infection 24.26 9.70 92 147967 131236 110310004
Housebound 24.18 9.70 12 148047 451 110440789
Drug level increased 24.16 9.70 127 147932 47592 110393648
Aspergillus infection 23.99 9.70 3 148056 25613 110415627
Type 2 diabetes mellitus 23.98 9.70 139 147920 177093 110264147
Blood lactate dehydrogenase increased 23.84 9.70 120 147939 44214 110397026
Hypocoagulable state 23.80 9.70 23 148036 2592 110438648
Mental disorder 23.76 9.70 109 147950 38682 110402558
Mucosal prolapse syndrome 23.72 9.70 5 148054 7 110441233
Frequent bowel movements 23.48 9.70 37 148022 71353 110369887
Oxygen saturation abnormal 23.35 9.70 33 148026 5578 110435662
Feeling guilty 23.34 9.70 15 148044 931 110440309
Toxic shock syndrome 23.27 9.70 18 148041 1502 110439738
Judgement impaired 23.14 9.70 17 148042 1313 110439927
Diarrhoea 23.13 9.70 1269 146790 1138236 109303004
Labelled drug-drug interaction issue 23.11 9.70 28 148031 4073 110437167
Pneumonitis 23.02 9.70 42 148017 76489 110364751
Trichotillomania 22.86 9.70 9 148050 192 110441048
Inflammation 22.83 9.70 158 147901 193080 110248160
Transplant rejection 22.71 9.70 3 148056 24564 110416676
Haemophagocytic lymphohistiocytosis 22.67 9.70 7 148052 31552 110409688
Mental status changes 22.64 9.70 177 147882 75945 110365295
Pneumonia aspiration 22.59 9.70 186 147873 81047 110360193
Therapy non-responder 22.58 9.70 121 147938 157186 110284054
Idiosyncratic alcohol intoxication 22.47 9.70 4 148055 0 110441240
Aspermia 22.47 9.70 4 148055 0 110441240
Tonic convulsion 22.44 9.70 24 148035 3050 110438190
Colitis microscopic 22.37 9.70 53 148006 13341 110427899
Mental impairment 22.37 9.70 74 147985 22565 110418675
Vasculitis 22.34 9.70 10 148049 35863 110405377
Platelet count decreased 22.30 9.70 199 147860 230244 110210996
Injection site erythema 22.29 9.70 59 148000 94117 110347123
Hepatic cytolysis 22.27 9.70 138 147921 54915 110386325
White blood cell count decreased 22.24 9.70 198 147861 229192 110212048
Muscular weakness 22.15 9.70 219 147840 248249 110192991
Diabetes insipidus 22.14 9.70 35 148024 6535 110434705
Alcohol interaction 22.10 9.70 26 148033 3668 110437572
Onychomycosis 22.09 9.70 12 148047 38519 110402721
Amnesia 22.05 9.70 227 147832 105181 110336059
Cholestasis 22.02 9.70 155 147904 64363 110376877
Persecutory delusion 21.87 9.70 34 148025 6257 110434983
Dissociative disorder 21.79 9.70 16 148043 1235 110440005
Haematoma muscle 21.56 9.70 27 148032 4063 110437177
Ejaculation disorder 21.55 9.70 12 148047 572 110440668
Death 21.48 9.70 743 147316 698126 109743114
Feelings of worthlessness 21.44 9.70 12 148047 578 110440662
Drug screen positive 21.39 9.70 34 148025 6376 110434864
Antidepressant drug level above therapeutic 21.18 9.70 13 148046 744 110440496
Cerebral microhaemorrhage 21.08 9.70 11 148048 460 110440780
Sensory loss 21.08 9.70 70 147989 21387 110419853
Muscle tightness 21.06 9.70 55 148004 14707 110426533
Parkinson's disease 20.94 9.70 17 148042 1522 110439718
Product administration error 20.91 9.70 102 147957 37115 110404125
Troponin increased 20.78 9.70 87 147972 29679 110411561
Head injury 20.77 9.70 113 147946 42904 110398336
Lethargy 20.76 9.70 204 147855 93372 110347868
Neoplasm progression 20.75 9.70 34 148025 64561 110376679
Torsade de pointes 20.68 9.70 72 147987 22528 110418712
Trismus 20.67 9.70 34 148025 6562 110434678
Psychiatric symptom 20.59 9.70 41 148018 9172 110432068
Cardiac failure 20.44 9.70 157 147902 187469 110253771
Hypersomnia 20.37 9.70 83 147976 27978 110413262
Disinhibition 20.33 9.70 23 148036 3111 110438129
Accommodation disorder 20.31 9.70 12 148047 641 110440599
Aphasia 20.29 9.70 142 147917 58855 110382385
Clostridium difficile infection 20.18 9.70 24 148035 52105 110389135
Ear infection 20.17 9.70 33 148026 62699 110378541
Retinitis 20.15 9.70 9 148050 32318 110408922
Prostate cancer 19.79 9.70 13 148046 37628 110403612
Pneumocystis jirovecii pneumonia 19.59 9.70 17 148042 42718 110398522
Skin laceration 19.32 9.70 93 147966 33660 110407580
Respiratory arrest 19.28 9.70 139 147920 58160 110383080
Palmar-plantar erythrodysaesthesia syndrome 19.20 9.70 16 148043 41009 110400231
Prescribed overdose 19.15 9.70 57 148002 87524 110353716
Generalised tonic-clonic seizure 19.03 9.70 132 147927 54548 110386692
Oedema peripheral 18.79 9.70 318 147741 328342 110112898
Fluid retention 18.79 9.70 64 147995 94243 110346997
Drug resistance 18.74 9.70 29 148030 56345 110384895
Sluggishness 18.53 9.70 35 148024 7532 110433708
Poriomania 18.43 9.70 8 148051 220 110441020
Brugada syndrome 18.42 9.70 16 148043 1572 110439668
Enuresis 18.41 9.70 25 148034 4071 110437169
Immunodeficiency 18.36 9.70 15 148044 38823 110402417
Antidepressant drug level increased 18.32 9.70 11 148048 605 110440635
Coronary artery disease 18.27 9.70 161 147898 71529 110369711
Depressive symptom 18.27 9.70 37 148022 8377 110432863
Substance use disorder 18.20 9.70 34 148025 7256 110433984
Night sweats 18.17 9.70 105 147954 133878 110307362
Behaviour disorder 18.14 9.70 40 148019 9607 110431633
Transvestism 18.09 9.70 4 148055 8 110441232
Colitis 18.06 9.70 73 147986 102250 110338990
Abdominal pain 18.00 9.70 536 147523 512453 109928787
Myoglobin blood increased 17.78 9.70 25 148034 4207 110437033
Onychomadesis 17.70 9.70 21 148038 45642 110395598
Bradypnoea 17.56 9.70 37 148022 8612 110432628
Dry mouth 17.50 9.70 177 147882 199771 110241469
Plasmodium vivax infection 17.47 9.70 4 148055 10 110441230
Cholecystitis chronic 17.42 9.70 39 148020 9461 110431779
Blood chloride decreased 17.37 9.70 38 148021 9077 110432163
Poor quality sleep 17.27 9.70 79 147980 27998 110413242
Wrong patient 17.18 9.70 15 148044 1484 110439756
Cyclothymic disorder 17.17 9.70 8 148051 261 110440979
Drug ineffective for unapproved indication 17.14 9.70 75 147984 102763 110338477
Phonophobia 17.13 9.70 11 148048 682 110440558
Abortion missed 16.86 9.70 15 148044 1522 110439718
Thrombotic microangiopathy 16.83 9.70 9 148050 29140 110412100
Hyperkinesia 16.75 9.70 21 148038 3163 110438077
Hospitalisation 16.59 9.70 117 147942 142376 110298864
Pleural effusion 16.52 9.70 155 147904 177554 110263686
Excessive sexual fantasies 16.47 9.70 4 148055 14 110441226
Alanine aminotransferase increased 16.37 9.70 341 147718 183432 110257808
Pruritus 16.34 9.70 625 147434 580935 109860305
Maternal exposure timing unspecified 16.33 9.70 4 148055 21009 110420231
Eyelid disorder 16.20 9.70 18 148041 2387 110438853
Lupus vulgaris 16.12 9.70 13 148046 33870 110407370
Posterior reversible encephalopathy syndrome 16.10 9.70 13 148046 33848 110407392
Somatic dysfunction 15.99 9.70 5 148054 52 110441188
Mitochondrial encephalomyopathy 15.98 9.70 6 148053 112 110441128
Administration related reaction 15.97 9.70 8 148051 307 110440933
Skin necrosis 15.91 9.70 64 147995 21448 110419792
Anticoagulation drug level abnormal 15.85 9.70 8 148051 312 110440928
Tri-iodothyronine free decreased 15.77 9.70 9 148050 450 110440790
Lactose intolerance 15.72 9.70 19 148040 2757 110438483
Marital problem 15.69 9.70 7 148052 206 110441034
Dizziness postural 15.56 9.70 49 148010 14560 110426680
Hepatic cirrhosis 15.53 9.70 43 148016 67583 110373657
Dissociative amnesia 15.51 9.70 6 148053 122 110441118
Clumsiness 15.39 9.70 22 148037 3758 110437482
Abdominal distension 15.32 9.70 155 147904 174948 110266292
Gamma-glutamyltransferase increased 15.27 9.70 137 147922 61172 110380068
Productive cough 15.27 9.70 90 147969 114215 110327025
Stupor 15.23 9.70 34 148025 8231 110433009
Blood triglycerides increased 15.22 9.70 68 147991 23858 110417382
Macular degeneration 15.21 9.70 5 148054 21654 110419586
Suicidal behaviour 15.20 9.70 21 148038 3476 110437764
Haemorrhagic diathesis 15.11 9.70 32 148027 7476 110433764
Bacterial infection 15.00 9.70 24 148035 46012 110395228
Impaired quality of life 14.94 9.70 11 148048 30006 110411234
Diet refusal 14.93 9.70 11 148048 853 110440387
Antisocial behaviour 14.89 9.70 11 148048 857 110440383
Altered visual depth perception 14.86 9.70 9 148050 503 110440737
Injection site reaction 14.82 9.70 65 147994 89005 110352235
Bronchopulmonary aspergillosis 14.79 9.70 11 148048 29852 110411388
Dysacusis 14.78 9.70 3 148056 3 110441237
Congenital muscle absence 14.72 9.70 4 148055 24 110441216
Rheumatoid nodule 14.70 9.70 60 147999 20236 110421004
Apallic syndrome 14.59 9.70 12 148047 1094 110440146
Legal problem 14.55 9.70 6 148053 145 110441095
Lupus-like syndrome 14.53 9.70 20 148039 40772 110400468
Diabetic hyperosmolar coma 14.51 9.70 11 148048 891 110440349
Sleep disorder due to a general medical condition 14.45 9.70 30 148029 52082 110389158
Localised infection 14.45 9.70 22 148037 43026 110398214
Tumour lysis syndrome 14.43 9.70 12 148047 30789 110410451
Blood bicarbonate decreased 14.42 9.70 27 148032 5770 110435470
Arthritis 14.40 9.70 149 147910 167437 110273803
Myocardial bridging 14.32 9.70 4 148055 27 110441213
Bladder dilatation 14.31 9.70 17 148042 2422 110438818
Psychomotor retardation 14.30 9.70 32 148027 7760 110433480
X-ray abnormal 14.28 9.70 18 148041 38099 110403141
Granuloma 14.20 9.70 36 148023 9454 110431786
Oesophageal disorder 14.20 9.70 19 148040 3051 110438189
Gaze palsy 14.12 9.70 20 148039 3387 110437853
Heterophoria 14.09 9.70 5 148054 79 110441161
Gambling disorder 14.08 9.70 16 148043 2175 110439065
Compartment syndrome 14.05 9.70 27 148032 5883 110435357
Pleurothotonus 13.99 9.70 17 148042 2481 110438759
C-reactive protein 13.98 9.70 12 148047 30319 110410921
Hyperlipidaemia 13.96 9.70 89 147970 35759 110405481
Fatigue 13.90 9.70 1421 146638 1214537 109226703
Influenza like illness 13.83 9.70 180 147879 88232 110353008
Hypoosmolar state 13.82 9.70 8 148051 411 110440829
Injection site pruritus 13.81 9.70 30 148029 51228 110390012
Amimia 13.80 9.70 5 148054 84 110441156
Convulsions local 13.80 9.70 5 148054 84 110441156
Suspiciousness 13.79 9.70 10 148049 757 110440483
Enterococcal infection 13.79 9.70 5 148054 20361 110420879
Decreased activity 13.77 9.70 39 148020 10935 110430305
Cerebrovascular stenosis 13.73 9.70 6 148053 168 110441072
Palpitations 13.72 9.70 294 147765 158918 110282322
Sleep apnoea syndrome 13.70 9.70 97 147962 40350 110400890
Inappropriate schedule of product administration 13.69 9.70 191 147868 203446 110237794
Perseveration 13.68 9.70 8 148051 419 110440821
Vascular stenosis 13.66 9.70 10 148049 768 110440472
Hallucination, olfactory 13.63 9.70 9 148050 585 110440655
Neonatal seizure 13.62 9.70 4 148055 33 110441207
Slow response to stimuli 13.60 9.70 15 148044 1973 110439267
Road traffic accident 13.60 9.70 86 147973 107312 110333928
Therapy interrupted 13.55 9.70 29 148030 49793 110391447
Cardiotoxicity 13.54 9.70 3 148056 16878 110424362
Gait inability 13.53 9.70 117 147942 136259 110304981
Infusion site scar 13.53 9.70 8 148051 428 110440812
Nasal ulcer 13.51 9.70 17 148042 2570 110438670
Anaemia neonatal 13.51 9.70 4 148055 34 110441206
Metastases to lung 13.49 9.70 7 148052 23056 110418184
Hyperventilation 13.45 9.70 34 148025 8913 110432327
COVID-19 pneumonia 13.44 9.70 18 148041 37125 110404115
Gastric infection 13.38 9.70 22 148037 4244 110436996
Impatience 13.26 9.70 10 148049 804 110440436
Wound complication 13.22 9.70 27 148032 6150 110435090
Ankle fracture 13.12 9.70 57 148002 19762 110421478
Injury 13.11 9.70 163 147896 177102 110264138
Chronic kidney disease 13.10 9.70 55 148004 76236 110365004
Product label confusion 13.09 9.70 7 148052 22670 110418570
Psoriasis 13.06 9.70 122 147937 139871 110301369
Cystocele 13.02 9.70 11 148048 1041 110440199
Cellulitis 13.00 9.70 107 147952 125909 110315331
Vulvovaginal pruritus 13.00 9.70 19 148040 3312 110437928
Energy increased 12.97 9.70 20 148039 3654 110437586
Psychomotor skills impaired 12.97 9.70 29 148030 7029 110434211
Hyperphosphataemia 12.97 9.70 3 148056 16378 110424862
Acute pulmonary oedema 12.92 9.70 51 148008 16945 110424295
Flank pain 12.71 9.70 63 147996 23067 110418173
Blood aldosterone abnormal 12.67 9.70 4 148055 43 110441197
Narcolepsy 12.67 9.70 13 148046 1575 110439665
Nephrogenic diabetes insipidus 12.66 9.70 16 148043 2429 110438811
Cytopenia 12.61 9.70 13 148046 30103 110411137
Hypocalcaemia 12.59 9.70 45 148014 65321 110375919
Concussion 12.57 9.70 39 148020 11499 110429741
Libido disorder 12.55 9.70 7 148052 335 110440905
Laboratory test abnormal 12.55 9.70 25 148034 44054 110397186
Product dose omission in error 12.52 9.70 8 148051 23504 110417736
Campylobacter colitis 12.51 9.70 5 148054 111 110441129
Pseudohallucination 12.51 9.70 6 148053 209 110441031
Anterograde amnesia 12.49 9.70 10 148049 878 110440362
Skin haemorrhage 12.48 9.70 9 148050 24818 110416422
Myocarditis bacterial 12.47 9.70 3 148056 10 110441230
Intention tremor 12.43 9.70 10 148049 884 110440356
Decreased interest 12.39 9.70 23 148036 4885 110436355
Product dispensing error 12.39 9.70 49 148010 16296 110424944
Pancreas infection 12.39 9.70 8 148051 501 110440739
Potentiating drug interaction 12.36 9.70 39 148020 11604 110429636
Orgasm abnormal 12.35 9.70 6 148053 215 110441025
Neurological decompensation 12.33 9.70 28 148031 6855 110434385
Rash erythematous 12.27 9.70 62 147997 81770 110359470
Injection site swelling 12.26 9.70 42 148017 61748 110379492
Appendicitis 12.24 9.70 12 148047 28452 110412788
Fibrocystic breast disease 12.23 9.70 9 148050 697 110440543
No adverse event 12.21 9.70 54 148005 73785 110367455
Thought insertion 12.13 9.70 4 148055 50 110441190
Bladder cancer 12.11 9.70 6 148053 20286 110420954
Bruxism 12.10 9.70 23 148036 4971 110436269
Leukopenia 12.09 9.70 134 147925 148657 110292583
Homosexuality 12.05 9.70 4 148055 51 110441189
Dyssomnia 12.05 9.70 4 148055 51 110441189
Epistaxis 12.00 9.70 114 147945 130258 110310982
Rhinalgia 11.97 9.70 20 148039 3909 110437331
Tracheal injury 11.96 9.70 6 148053 231 110441009
Inappropriate affect 11.94 9.70 13 148046 1686 110439554
Intentional device use issue 11.93 9.70 5 148054 126 110441114
Weight increased 11.88 9.70 681 147378 418963 110022277
Metastases to central nervous system 11.83 9.70 8 148051 22809 110418431
Personality change 11.81 9.70 37 148022 10965 110430275
Drug tolerance decreased 11.75 9.70 70 147989 27470 110413770
Food allergy 11.75 9.70 6 148053 19942 110421298
Incorrect route of product administration 11.75 9.70 45 148014 64016 110377224
Benzodiazepine drug level increased 11.70 9.70 6 148053 242 110440998
Drug hypersensitivity 11.67 9.70 493 147566 453597 109987643
Asthma 11.59 9.70 251 147808 250040 110191200
Paroxysmal arrhythmia 11.46 9.70 4 148055 60 110441180
Posture abnormal 11.46 9.70 21 148038 4417 110436823
Angina unstable 11.45 9.70 48 148011 16384 110424856
Osteoporosis 11.44 9.70 69 147990 87083 110354157
Delivery 11.44 9.70 10 148049 991 110440249
Cardiac septal hypertrophy 11.39 9.70 7 148052 402 110440838
Delusional perception 11.39 9.70 7 148052 402 110440838
Pneumonia bacterial 11.38 9.70 11 148048 26250 110414990
Serum sickness-like reaction 11.35 9.70 9 148050 779 110440461
Nephropathy toxic 11.35 9.70 12 148047 27466 110413774
Vascular access site pain 11.25 9.70 8 148051 587 110440653
Ligament sprain 11.25 9.70 47 148012 16021 110425219
Abdominal pain upper 11.21 9.70 369 147690 348742 110092498
Renal impairment 11.20 9.70 181 147878 188264 110252976
Theft 11.20 9.70 6 148053 265 110440975
Autoimmune nephritis 11.19 9.70 9 148050 795 110440445
Yawning 11.15 9.70 12 148047 1535 110439705
Thoracic outlet syndrome 11.15 9.70 5 148054 149 110441091
Antipsychotic drug level above therapeutic 11.13 9.70 15 148044 2425 110438815
Dysstasia 11.11 9.70 79 147980 32907 110408333
Neurosis 11.07 9.70 8 148051 602 110440638
Arthritis enteropathic 11.05 9.70 7 148052 424 110440816
Plasma cell myeloma 11.04 9.70 45 148014 62891 110378349
Multiple organ dysfunction syndrome 11.03 9.70 140 147919 151570 110289670
Intra-abdominal haematoma 11.02 9.70 18 148041 3454 110437786
Immunosuppression 10.98 9.70 5 148054 17754 110423486
Pulmonary toxicity 10.97 9.70 5 148054 17741 110423499
Antisocial personality disorder 10.89 9.70 4 148055 70 110441170
Blood potassium increased 10.84 9.70 79 147980 33170 110408070
Drug dose omission by device 10.83 9.70 3 148056 14513 110426727
Impulse-control disorder 10.80 9.70 14 148045 2180 110439060
Inflammatory marker increased 10.78 9.70 3 148056 14466 110426774
Mouth ulceration 10.76 9.70 31 148028 48107 110393133
Dermatitis allergic 10.76 9.70 8 148051 21716 110419524
Communication disorder 10.75 9.70 22 148037 5017 110436223
Uveitis 10.75 9.70 8 148051 21702 110419538
Vasoplegia syndrome 10.74 9.70 23 148036 5416 110435824
Rhinitis 10.73 9.70 59 148000 22486 110418754
Carotid artery disease 10.65 9.70 14 148045 2209 110439031
Nodule 10.64 9.70 17 148042 32614 110408626
Gastrointestinal anastomotic stenosis 10.64 9.70 4 148055 75 110441165
Oral candidiasis 10.62 9.70 28 148031 44732 110396508
Product selection error 10.62 9.70 7 148052 454 110440786
Device difficult to use 10.57 9.70 6 148053 18799 110422441
Prescription drug used without a prescription 10.57 9.70 23 148036 5473 110435767
Grimacing 10.57 9.70 9 148050 861 110440379
Porphyria acute 10.55 9.70 6 148053 18774 110422466
Drug screen false positive 10.55 9.70 11 148048 1358 110439882
Transcription medication error 10.54 9.70 8 148051 649 110440591
Hypervigilance 10.54 9.70 8 148051 649 110440591
Normetanephrine urine increased 10.52 9.70 3 148056 22 110441218
Gastrointestinal ulcer haemorrhage 10.52 9.70 12 148047 1638 110439602
Glomerular filtration rate decreased 10.51 9.70 14 148045 28942 110412298
Jealous delusion 10.45 9.70 7 148052 466 110440774
Delusional disorder, unspecified type 10.38 9.70 9 148050 882 110440358
Platelet function test abnormal 10.33 9.70 5 148054 178 110441062
Haemolysis 10.32 9.70 4 148055 15635 110425605
Paraphilia 10.31 9.70 4 148055 82 110441158
Walking aid user 10.30 9.70 11 148048 25064 110416176
Cardiac valve disease 10.29 9.70 25 148034 6396 110434844
Coagulation factor V level decreased 10.27 9.70 8 148051 675 110440565
Chronic spontaneous urticaria 10.25 9.70 13 148046 1980 110439260
Job dissatisfaction 10.22 9.70 4 148055 84 110441156
Feeling of relaxation 10.20 9.70 5 148054 183 110441057
Pigmentation disorder 10.19 9.70 27 148032 7284 110433956
Breast cancer stage II 10.18 9.70 13 148046 27362 110413878
Drowning 10.16 9.70 9 148050 908 110440332
Respiratory tract congestion 10.14 9.70 16 148043 30841 110410399
Nervous system disorder 10.13 9.70 75 147984 31646 110409594
Transaminases increased 10.10 9.70 47 148012 63343 110377897
Third stage postpartum haemorrhage 10.08 9.70 3 148056 26 110441214
Ammonia abnormal 10.06 9.70 6 148053 326 110440914
Hypothermia 10.06 9.70 65 147994 26237 110415003
Adverse reaction 10.05 9.70 15 148044 29579 110411661
Glucose tolerance test abnormal 10.05 9.70 4 148055 88 110441152
Therapeutic response shortened 10.04 9.70 15 148044 29568 110411672
Post procedural haematuria 10.04 9.70 6 148053 327 110440913
Thoracic radiculopathy 9.98 9.70 3 148056 27 110441213
Blepharitis 9.86 9.70 20 148039 4532 110436708
Peripheral sensory neuropathy 9.85 9.70 5 148054 16675 110424565
Blood osmolarity decreased 9.85 9.70 11 148048 1467 110439773
Prescription form tampering 9.84 9.70 7 148052 514 110440726
Psychiatric decompensation 9.83 9.70 23 148036 5742 110435498
Vessel puncture site bruise 9.83 9.70 7 148052 515 110440725
Second primary malignancy 9.83 9.70 6 148053 18062 110423178
Motor dysfunction 9.76 9.70 61 147998 24345 110416895
Foetal exposure during pregnancy 9.74 9.70 27 148032 7478 110433762
Haemoglobin decreased 9.70 9.70 256 147803 248471 110192769
Bacteraemia 9.70 9.70 27 148032 42363 110398877

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06AB05 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
MeSH PA D000928 Antidepressive Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D017367 Selective Serotonin Reuptake Inhibitors
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018490 Serotonin Agents
MeSH PA D018687 Antidepressive Agents, Second-Generation
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D065690 Cytochrome P-450 CYP2D6 Inhibitors
FDA EPC N0000175696 Serotonin Reuptake Inhibitor
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:50183 P450 inhibitor
CHEBI has role CHEBI:50908 hepatotoxic agent
CHEBI has role CHEBI:50949 serotonin uptake inhibitor

Related Drugs by ATC class:

N06AB Selective serotonin reuptake inhibitors 7 drugs
citalopramescitaloprametoperidonefluoxetinefluvoxaminesertralinezimeldine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Premenstrual dysphoric disorder indication 596004
Generalized anxiety disorder indication 21897009 DOID:14320
Social phobia indication 25501002 DOID:11257
Depressive disorder indication 35489007
Posttraumatic stress disorder indication 47505003 DOID:2055
Obsessive-compulsive disorder indication 191736004 DOID:10933
Menopausal flushing indication 198436008
Major depressive disorder indication 370143000
Panic disorder indication 371631005 DOID:594
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Fibromyalgia off-label use 203082005 DOID:631
Suicidal thoughts contraindication 6471006
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Upper gastrointestinal hemorrhage contraindication 37372002
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Hyponatremia contraindication 89627008
Seizure disorder contraindication 128613002
Mania contraindication 231494001
Disease of liver contraindication 235856003 DOID:409
Pathological fracture contraindication 268029009
Akathisia contraindication 285145004
Pregnancy, function contraindication 289908002
Serotonin syndrome contraindication 371089000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.51 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 7.5MG BASE BRISDELLE LEGACY N204516 June 28, 2013 RX CAPSULE ORAL 8946251 Aug. 4, 2026 TREATMENT OF MODERATE TO SEVERE VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE
EQ 7.5MG BASE BRISDELLE LEGACY N204516 June 28, 2013 RX CAPSULE ORAL 9393237 Aug. 4, 2026 TREATMENT OF MODERATE TO SEVERE VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE
EQ 7.5MG BASE BRISDELLE LEGACY N204516 June 28, 2013 RX CAPSULE ORAL 8658663 April 6, 2029 TREATMENT OF MODERATE TO SEVERE VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Ki 10.40 CHEMBL CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 5.65 DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2 Ion channel Ki 5.07 DRUG MATRIX
Cytochrome P450 3A4 Enzyme IC50 4.70 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Kd 7.40 WOMBAT-PK
5-hydroxytryptamine receptor 1A GPCR Kd 4.52 CHEMBL
5-hydroxytryptamine receptor 6 GPCR Ki 9.22 CHEMBL
D(3) dopamine receptor GPCR Ki 5.42 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 7.46 DRUG MATRIX
Muscarinic acetylcholine receptor M2 GPCR Ki 6.72 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 7.42 DRUG MATRIX
Muscarinic acetylcholine receptor M4 GPCR Ki 7.47 DRUG MATRIX
Muscarinic acetylcholine receptor M5 GPCR Ki 7.05 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Kd 6.31 WOMBAT-PK
Cytochrome P450 2D6 Enzyme IC50 6 DRUG MATRIX
Cytochrome P450 1A2 Enzyme IC50 4.96 WOMBAT-PK
Substance-P receptor GPCR IC50 6.05 CHEMBL
Potassium voltage-gated channel subfamily A member 3 Ion channel IC50 4.50 CHEMBL
Myeloperoxidase Enzyme IC50 7.70 CHEMBL
Beta-adrenergic receptor kinase 1 Kinase IC50 5.86 CHEMBL
P2X purinoceptor 4 Ion channel IC50 5.33 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5 WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 10.30 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 7.01 CHEMBL
Transporter Transporter Ki 7.48 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 9.36 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 7.70 CHEMBL
Transporter Transporter Ki 7.23 CHEMBL
Quinolone resistance protein NorA Transporter IC50 5.15 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 5.20 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 5.27 CHEMBL
P2X purinoceptor 4 Ion channel IC50 5.61 CHEMBL
Beta-adrenergic receptor kinase 1 Kinase IC50 5.89 CHEMBL

External reference:

IDSource
D02260 KEGG_DRUG
110429-35-1 SECONDARY_CAS_RN
217797-14-3 SECONDARY_CAS_RN
78246-49-8 SECONDARY_CAS_RN
4020738 VANDF
4020815 VANDF
C0070122 UMLSCUI
CHEBI:7936 CHEBI
8PR PDB_CHEM_ID
CHEMBL490 ChEMBL_ID
CHEMBL6067650 ChEMBL_ID
CHEMBL1200609 ChEMBL_ID
DB00715 DRUGBANK_ID
CHEMBL1256912 ChEMBL_ID
D017374 MESH_DESCRIPTOR_UI
43815 PUBCHEM_CID
4790 IUPHAR_LIGAND_ID
4327 INN_ID
41VRH5220H UNII
114228 RXNORM
18339 MMSL
205288 MMSL
262886 MMSL
29631 MMSL
4517 MMSL
47422 MMSL
5236 MMSL
d03157 MMSL
004016 NDDF
004017 NDDF
008361 NDDF
1269153001 SNOMEDCT_US
321963000 SNOMEDCT_US
372595009 SNOMEDCT_US
411000220105 SNOMEDCT_US
420495003 SNOMEDCT_US
96214003 SNOMEDCT_US
41VRH5220H INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0378-7001 TABLET, FILM COATED 10 mg ORAL ANDA 29 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0378-7002 TABLET, FILM COATED 20 mg ORAL ANDA 29 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0378-7003 TABLET, FILM COATED 30 mg ORAL ANDA 29 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0378-7004 TABLET, FILM COATED 40 mg ORAL ANDA 29 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0574-0279 CAPSULE 7.50 mg ORAL NDA authorized generic 28 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-7985 TABLET, FILM COATED 20 mg ORAL ANDA 24 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8173 TABLET, FILM COATED 30 mg ORAL ANDA 24 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8174 TABLET, FILM COATED 40 mg ORAL ANDA 24 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8359 TABLET, FILM COATED 10 mg ORAL ANDA 25 sections
PAROXETINE HUMAN PRESCRIPTION DRUG LABEL 1 0904-5676 TABLET, FILM COATED 10 mg ORAL ANDA 21 sections
PAROXETINE HUMAN PRESCRIPTION DRUG LABEL 1 0904-5677 TABLET, FILM COATED 20 mg ORAL ANDA 21 sections
PAROXETINE HUMAN PRESCRIPTION DRUG LABEL 1 0904-5678 TABLET, FILM COATED 30 mg ORAL ANDA 21 sections
PAROXETINE HUMAN PRESCRIPTION DRUG LABEL 1 0904-5679 TABLET, FILM COATED 40 mg ORAL ANDA 21 sections
PAROXETINE HUMAN PRESCRIPTION DRUG LABEL 1 10544-433 TABLET, FILM COATED 20 mg ORAL ANDA 32 sections
PAROXETINE HUMAN PRESCRIPTION DRUG LABEL 1 10544-809 TABLET, FILM COATED 40 mg ORAL ANDA 32 sections
PAROXETINE HUMAN PRESCRIPTION DRUG LABEL 1 12634-248 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
Paroxetine Human Prescription Drug Label 1 13107-154 TABLET, FILM COATED 10 mg ORAL ANDA 29 sections
Paroxetine Human Prescription Drug Label 1 13107-155 TABLET, FILM COATED 20 mg ORAL ANDA 29 sections
Paroxetine Human Prescription Drug Label 1 13107-156 TABLET, FILM COATED 30 mg ORAL ANDA 29 sections
Paroxetine Human Prescription Drug Label 1 13107-157 TABLET, FILM COATED 40 mg ORAL ANDA 29 sections
PAROXETINE Human Prescription Drug Label 1 16590-181 TABLET, FILM COATED 20 mg ORAL ANDA 25 sections
PAROXETINE Human Prescription Drug Label 1 16590-322 TABLET, FILM COATED 10 mg ORAL ANDA 30 sections
PAXILCR HUMAN PRESCRIPTION DRUG LABEL 1 16590-514 TABLET, FILM COATED, EXTENDED RELEASE 12.50 mg ORAL NDA 15 sections
Paroxetine Human Prescription Drug Label 1 16714-181 TABLET, FILM COATED 10 mg ORAL ANDA 29 sections
Paroxetine Human Prescription Drug Label 1 16714-182 TABLET, FILM COATED 20 mg ORAL ANDA 29 sections
Paroxetine Human Prescription Drug Label 1 16714-183 TABLET, FILM COATED 30 mg ORAL ANDA 29 sections
Paroxetine Human Prescription Drug Label 1 16714-184 TABLET, FILM COATED 40 mg ORAL ANDA 29 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 21695-101 TABLET, FILM COATED 10 mg ORAL ANDA 22 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 21695-102 TABLET, FILM COATED 20 mg ORAL ANDA 22 sections
Paroxetine HUMAN PRESCRIPTION DRUG LABEL 1 21695-103 TABLET, FILM COATED 30 mg ORAL ANDA 22 sections