Stem definition | Drug id | CAS RN |
---|---|---|
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives | 1209 | 54910-89-3 |
Dose | Unit | Route |
---|---|---|
20 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 15.20 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 1.25 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 4.30 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 60 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 29, 1987 | FDA | ELI LILLY AND CO |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1384.32 | 9.81 | 1729 | 133111 | 130160 | 50340124 |
Intentional overdose | 822.75 | 9.81 | 921 | 133919 | 61583 | 50408701 |
Toxicity to various agents | 710.32 | 9.81 | 1673 | 133167 | 210826 | 50259458 |
Suicidal ideation | 697.99 | 9.81 | 798 | 134042 | 54587 | 50415697 |
Serotonin syndrome | 506.45 | 9.81 | 463 | 134377 | 24250 | 50446034 |
Drug abuse | 481.28 | 9.81 | 690 | 134150 | 59156 | 50411128 |
Suicide attempt | 469.15 | 9.81 | 632 | 134208 | 51100 | 50419184 |
Intentional self-injury | 446.48 | 9.81 | 419 | 134421 | 22693 | 50447591 |
Drug interaction | 422.27 | 9.81 | 1329 | 133511 | 198292 | 50271992 |
Electrocardiogram QT prolonged | 319.69 | 9.81 | 529 | 134311 | 51357 | 50418927 |
Anxiety | 294.92 | 9.81 | 1091 | 133749 | 176515 | 50293769 |
Tremor | 290.07 | 9.81 | 815 | 134025 | 114088 | 50356196 |
Systemic lupus erythematosus | 271.93 | 9.81 | 29 | 134811 | 140593 | 50329691 |
Agitation | 264.98 | 9.81 | 495 | 134345 | 52889 | 50417395 |
Drug intolerance | 263.87 | 9.81 | 127 | 134713 | 218977 | 50251307 |
Synovitis | 251.55 | 9.81 | 21 | 134819 | 123844 | 50346440 |
Hand deformity | 238.47 | 9.81 | 6 | 134834 | 100193 | 50370091 |
Cardio-respiratory arrest | 236.05 | 9.81 | 474 | 134366 | 53418 | 50416866 |
Contraindicated product administered | 231.67 | 9.81 | 56 | 134784 | 148902 | 50321382 |
Drug withdrawal syndrome | 228.13 | 9.81 | 307 | 134533 | 24774 | 50445510 |
Depression | 224.36 | 9.81 | 954 | 133886 | 164469 | 50305815 |
Overdose | 219.68 | 9.81 | 674 | 134166 | 99053 | 50371231 |
Joint swelling | 212.80 | 9.81 | 204 | 134636 | 245082 | 50225202 |
Withdrawal syndrome | 212.20 | 9.81 | 248 | 134592 | 17342 | 50452942 |
Treatment failure | 209.66 | 9.81 | 54 | 134786 | 137583 | 50332701 |
Glossodynia | 190.70 | 9.81 | 38 | 134802 | 115531 | 50354753 |
Poisoning | 189.28 | 9.81 | 198 | 134642 | 12231 | 50458053 |
Respiratory arrest | 188.86 | 9.81 | 309 | 134531 | 29700 | 50440584 |
Infusion related reaction | 186.83 | 9.81 | 110 | 134730 | 169447 | 50300837 |
Cardiac arrest | 182.92 | 9.81 | 564 | 134276 | 83087 | 50387197 |
Irritability | 176.60 | 9.81 | 291 | 134549 | 28135 | 50442149 |
Rash | 173.79 | 9.81 | 592 | 134248 | 436879 | 50033405 |
Alopecia | 173.37 | 9.81 | 240 | 134600 | 244807 | 50225477 |
Wound | 172.03 | 9.81 | 36 | 134804 | 105758 | 50364526 |
Swelling | 157.38 | 9.81 | 182 | 134658 | 200690 | 50269594 |
Reversible cerebral vasoconstriction syndrome | 153.88 | 9.81 | 86 | 134754 | 2033 | 50468251 |
Pericarditis | 152.64 | 9.81 | 16 | 134824 | 78673 | 50391611 |
Somnolence | 152.62 | 9.81 | 815 | 134025 | 154170 | 50316114 |
Peripheral swelling | 150.38 | 9.81 | 197 | 134643 | 205739 | 50264545 |
Drug ineffective | 148.98 | 9.81 | 1433 | 133407 | 817900 | 49652384 |
Arthropathy | 143.15 | 9.81 | 126 | 134714 | 157780 | 50312504 |
Abdominal discomfort | 142.69 | 9.81 | 249 | 134591 | 231392 | 50238892 |
Akathisia | 141.53 | 9.81 | 140 | 134700 | 8089 | 50462195 |
Nightmare | 138.85 | 9.81 | 192 | 134648 | 15894 | 50454390 |
Aggression | 137.72 | 9.81 | 221 | 134619 | 20895 | 50449389 |
Torsade de pointes | 128.21 | 9.81 | 158 | 134682 | 11677 | 50458607 |
Disturbance in attention | 124.39 | 9.81 | 264 | 134576 | 30922 | 50439362 |
Hepatic enzyme increased | 120.47 | 9.81 | 113 | 134727 | 137267 | 50333017 |
Depressed mood | 118.73 | 9.81 | 273 | 134567 | 33750 | 50436534 |
Arthralgia | 117.66 | 9.81 | 687 | 134153 | 438015 | 50032269 |
Panic attack | 116.10 | 9.81 | 195 | 134645 | 19147 | 50451137 |
Mania | 115.47 | 9.81 | 144 | 134696 | 10772 | 50459512 |
Rheumatoid factor positive | 114.90 | 9.81 | 4 | 134836 | 49855 | 50420429 |
Infection | 114.77 | 9.81 | 177 | 134663 | 172777 | 50297507 |
Febrile neutropenia | 113.83 | 9.81 | 59 | 134781 | 97608 | 50372676 |
Suicidal behaviour | 113.02 | 9.81 | 73 | 134767 | 2261 | 50468023 |
Sopor | 110.89 | 9.81 | 194 | 134646 | 19685 | 50450599 |
Product complaint | 105.23 | 9.81 | 141 | 134699 | 11325 | 50458959 |
Therapeutic product effect decreased | 104.63 | 9.81 | 125 | 134715 | 135925 | 50334359 |
Crying | 104.61 | 9.81 | 192 | 134648 | 20224 | 50450060 |
Mydriasis | 102.65 | 9.81 | 134 | 134706 | 10493 | 50459791 |
White blood cell count abnormal | 100.01 | 9.81 | 96 | 134744 | 5344 | 50464940 |
Rheumatoid arthritis | 99.96 | 9.81 | 247 | 134593 | 202303 | 50267981 |
Product use issue | 99.13 | 9.81 | 153 | 134687 | 149322 | 50320962 |
Discomfort | 98.76 | 9.81 | 86 | 134754 | 108294 | 50361990 |
Foetal exposure during pregnancy | 98.20 | 9.81 | 222 | 134618 | 27137 | 50443147 |
Product substitution issue | 97.02 | 9.81 | 151 | 134689 | 13906 | 50456378 |
Seizure | 94.45 | 9.81 | 587 | 134253 | 117287 | 50352997 |
Helicobacter infection | 94.12 | 9.81 | 11 | 134829 | 49691 | 50420593 |
Duodenal ulcer perforation | 91.82 | 9.81 | 8 | 134832 | 45603 | 50424681 |
Neutropenia | 90.17 | 9.81 | 160 | 134680 | 147805 | 50322479 |
Hypersensitivity | 89.42 | 9.81 | 285 | 134555 | 214876 | 50255408 |
Muscle rigidity | 87.36 | 9.81 | 119 | 134721 | 9710 | 50460574 |
Respiratory depression | 87.09 | 9.81 | 132 | 134708 | 11878 | 50458406 |
Nasopharyngitis | 85.56 | 9.81 | 248 | 134592 | 192679 | 50277605 |
Self-injurious ideation | 84.72 | 9.81 | 60 | 134780 | 2169 | 50468115 |
Pneumonia | 83.96 | 9.81 | 627 | 134213 | 377774 | 50092510 |
Lower respiratory tract infection | 83.80 | 9.81 | 78 | 134762 | 95123 | 50375161 |
Coma scale abnormal | 83.59 | 9.81 | 82 | 134758 | 4689 | 50465595 |
Coma | 82.39 | 9.81 | 335 | 134505 | 56544 | 50413740 |
Suspected suicide | 80.95 | 9.81 | 85 | 134755 | 5272 | 50465012 |
Dystonia | 79.38 | 9.81 | 126 | 134714 | 11800 | 50458484 |
Folliculitis | 78.63 | 9.81 | 7 | 134833 | 39218 | 50431066 |
Stomatitis | 78.02 | 9.81 | 93 | 134747 | 101251 | 50369033 |
Blister | 77.55 | 9.81 | 68 | 134772 | 85350 | 50384934 |
Insomnia | 76.15 | 9.81 | 756 | 134084 | 174109 | 50296175 |
Galactorrhoea | 74.76 | 9.81 | 69 | 134771 | 3654 | 50466630 |
Anger | 73.05 | 9.81 | 118 | 134722 | 11215 | 50459069 |
Depressed level of consciousness | 72.89 | 9.81 | 303 | 134537 | 51650 | 50418634 |
Mood swings | 71.81 | 9.81 | 142 | 134698 | 15812 | 50454472 |
Bezoar | 69.84 | 9.81 | 44 | 134796 | 1304 | 50468980 |
Muscle twitching | 69.04 | 9.81 | 137 | 134703 | 15294 | 50454990 |
Abnormal behaviour | 68.87 | 9.81 | 158 | 134682 | 19500 | 50450784 |
Muscle injury | 68.34 | 9.81 | 9 | 134831 | 37102 | 50433182 |
Tearfulness | 67.66 | 9.81 | 65 | 134775 | 3622 | 50466662 |
Sleep disorder due to general medical condition, insomnia type | 67.65 | 9.81 | 4 | 134836 | 31443 | 50438841 |
Poisoning deliberate | 67.62 | 9.81 | 94 | 134746 | 7818 | 50462466 |
Off label use | 67.40 | 9.81 | 876 | 133964 | 473550 | 49996734 |
Hypertonia neonatal | 66.89 | 9.81 | 25 | 134815 | 219 | 50470065 |
Impaired healing | 66.49 | 9.81 | 53 | 134787 | 69733 | 50400551 |
Drug dependence | 66.14 | 9.81 | 156 | 134684 | 19603 | 50450681 |
Exposure during pregnancy | 65.79 | 9.81 | 549 | 134291 | 120466 | 50349818 |
Obsessive-compulsive disorder | 65.33 | 9.81 | 61 | 134779 | 3279 | 50467005 |
Hyperprolactinaemia | 64.94 | 9.81 | 61 | 134779 | 3304 | 50466980 |
Restlessness | 64.81 | 9.81 | 180 | 134660 | 24993 | 50445291 |
Pyrexia | 64.02 | 9.81 | 676 | 134164 | 379527 | 50090757 |
Electrocardiogram QRS complex prolonged | 63.86 | 9.81 | 75 | 134765 | 5269 | 50465015 |
Confusional state | 63.50 | 9.81 | 766 | 134074 | 185162 | 50285122 |
Hyperhidrosis | 63.45 | 9.81 | 432 | 134408 | 88994 | 50381290 |
Extrapyramidal disorder | 61.95 | 9.81 | 112 | 134728 | 11658 | 50458626 |
Hallucination, auditory | 61.53 | 9.81 | 106 | 134734 | 10622 | 50459662 |
Parkinsonism | 61 | 9.81 | 95 | 134745 | 8752 | 50461532 |
Myoclonus | 60.61 | 9.81 | 125 | 134715 | 14345 | 50455939 |
Miosis | 60.06 | 9.81 | 79 | 134761 | 6231 | 50464053 |
Generalised tonic-clonic seizure | 59.88 | 9.81 | 180 | 134660 | 26130 | 50444154 |
Restless legs syndrome | 59.29 | 9.81 | 131 | 134709 | 15766 | 50454518 |
Memory impairment | 59.08 | 9.81 | 388 | 134452 | 78972 | 50391312 |
General physical health deterioration | 58.20 | 9.81 | 190 | 134650 | 142244 | 50328040 |
Pancytopenia | 56.65 | 9.81 | 85 | 134755 | 83945 | 50386339 |
Sedation | 56.58 | 9.81 | 195 | 134645 | 30415 | 50439869 |
Malignant neoplasm progression | 56.27 | 9.81 | 59 | 134781 | 68065 | 50402219 |
Gastrointestinal disorder | 54.97 | 9.81 | 105 | 134735 | 94351 | 50375933 |
Disease progression | 54.55 | 9.81 | 108 | 134732 | 95758 | 50374526 |
Intentional product misuse | 54.53 | 9.81 | 258 | 134582 | 46476 | 50423808 |
Therapeutic product effect incomplete | 53.90 | 9.81 | 101 | 134739 | 91414 | 50378870 |
Anaemia | 53.68 | 9.81 | 423 | 134417 | 252033 | 50218251 |
Therapeutic response unexpected | 53.64 | 9.81 | 126 | 134714 | 15789 | 50454495 |
Platelet count decreased | 53.51 | 9.81 | 118 | 134722 | 100608 | 50369676 |
Drug withdrawal syndrome neonatal | 53.10 | 9.81 | 42 | 134798 | 1799 | 50468485 |
Cerebral vasoconstriction | 52.96 | 9.81 | 33 | 134807 | 959 | 50469325 |
Tardive dyskinesia | 52.77 | 9.81 | 80 | 134760 | 7199 | 50463085 |
Myocardial depression | 52.14 | 9.81 | 25 | 134815 | 425 | 50469859 |
Mood altered | 51.93 | 9.81 | 109 | 134731 | 12664 | 50457620 |
Emotional distress | 51.59 | 9.81 | 181 | 134659 | 28482 | 50441802 |
Paranoia | 51.35 | 9.81 | 96 | 134744 | 10252 | 50460032 |
Cholecystitis chronic | 50.88 | 9.81 | 92 | 134748 | 9577 | 50460707 |
Renal impairment | 50.55 | 9.81 | 77 | 134763 | 75584 | 50394700 |
Abnormal dreams | 50.34 | 9.81 | 90 | 134750 | 9287 | 50460997 |
Thrombocytopenia | 49.64 | 9.81 | 174 | 134666 | 127499 | 50342785 |
Mucosal inflammation | 48.64 | 9.81 | 23 | 134817 | 40119 | 50430165 |
Hyperreflexia | 48.60 | 9.81 | 64 | 134776 | 5054 | 50465230 |
Persistent genital arousal disorder | 48.55 | 9.81 | 20 | 134820 | 232 | 50470052 |
Libido increased | 48.50 | 9.81 | 34 | 134806 | 1209 | 50469075 |
Decorticate posture | 48.24 | 9.81 | 21 | 134819 | 282 | 50470002 |
Dyspnoea | 47.70 | 9.81 | 1104 | 133736 | 546504 | 49923780 |
Clonus | 47.27 | 9.81 | 57 | 134783 | 4118 | 50466166 |
Tic | 46.81 | 9.81 | 33 | 134807 | 1184 | 50469100 |
Impulsive behaviour | 45.83 | 9.81 | 35 | 134805 | 1423 | 50468861 |
Hostility | 45.79 | 9.81 | 38 | 134802 | 1744 | 50468540 |
Atrial fibrillation | 45.63 | 9.81 | 130 | 134710 | 101615 | 50368669 |
Pulseless electrical activity | 45.15 | 9.81 | 72 | 134768 | 6769 | 50463515 |
Dyskinesia | 45.12 | 9.81 | 170 | 134670 | 27691 | 50442593 |
Atrial septal defect | 44.99 | 9.81 | 69 | 134771 | 6272 | 50464012 |
Maternal exposure during breast feeding | 44.54 | 9.81 | 49 | 134791 | 3205 | 50467079 |
Accidental death | 44.42 | 9.81 | 37 | 134803 | 1707 | 50468577 |
Cough | 44.26 | 9.81 | 420 | 134420 | 240844 | 50229440 |
Amnesia | 44.10 | 9.81 | 226 | 134614 | 42034 | 50428250 |
Alcohol interaction | 43.56 | 9.81 | 40 | 134800 | 2104 | 50468180 |
Diarrhoea | 43.32 | 9.81 | 1216 | 133624 | 587260 | 49883024 |
C-reactive protein increased | 43.12 | 9.81 | 69 | 134771 | 66405 | 50403879 |
Pain | 42.92 | 9.81 | 1195 | 133645 | 577708 | 49892576 |
Intentional product use issue | 41.76 | 9.81 | 89 | 134751 | 76829 | 50393455 |
Long QT syndrome | 41.17 | 9.81 | 45 | 134795 | 2922 | 50467362 |
Sinusitis | 40.94 | 9.81 | 276 | 134564 | 170282 | 50300002 |
Ill-defined disorder | 40.11 | 9.81 | 52 | 134788 | 54602 | 50415682 |
Feeling abnormal | 39.78 | 9.81 | 510 | 134330 | 124982 | 50345302 |
Bradyphrenia | 39.57 | 9.81 | 64 | 134776 | 6088 | 50464196 |
Blood hyposmosis | 39.42 | 9.81 | 10 | 134830 | 17 | 50470267 |
Hip arthroplasty | 39.13 | 9.81 | 16 | 134824 | 30413 | 50439871 |
Stress cardiomyopathy | 38.93 | 9.81 | 73 | 134767 | 7814 | 50462470 |
Blood pressure fluctuation | 38.34 | 9.81 | 24 | 134816 | 35799 | 50434485 |
Ventricular fibrillation | 38.24 | 9.81 | 86 | 134754 | 10473 | 50459811 |
Mobility decreased | 38.21 | 9.81 | 99 | 134741 | 79849 | 50390435 |
Agitation neonatal | 38.13 | 9.81 | 21 | 134819 | 482 | 50469802 |
Euphoric mood | 37.41 | 9.81 | 50 | 134790 | 4005 | 50466279 |
Multiple sclerosis | 37.39 | 9.81 | 130 | 134710 | 20363 | 50449921 |
Depressive symptom | 36.74 | 9.81 | 44 | 134796 | 3156 | 50467128 |
Pre-eclampsia | 36.69 | 9.81 | 72 | 134768 | 7972 | 50462312 |
Dependence | 36.20 | 9.81 | 34 | 134806 | 1841 | 50468443 |
Anorgasmia | 36.20 | 9.81 | 21 | 134819 | 534 | 50469750 |
Atrioventricular block first degree | 35.20 | 9.81 | 61 | 134779 | 6140 | 50464144 |
Bone marrow failure | 34.76 | 9.81 | 15 | 134825 | 27609 | 50442675 |
Sinus bradycardia | 34.66 | 9.81 | 95 | 134745 | 13088 | 50457196 |
Knee arthroplasty | 34.42 | 9.81 | 27 | 134813 | 35819 | 50434465 |
Maternal drugs affecting foetus | 34.28 | 9.81 | 54 | 134786 | 5023 | 50465261 |
Hyponatraemia | 34.05 | 9.81 | 399 | 134441 | 95740 | 50374544 |
Morbid thoughts | 34.01 | 9.81 | 20 | 134820 | 522 | 50469762 |
Cogwheel rigidity | 33.88 | 9.81 | 32 | 134808 | 1745 | 50468539 |
Apathy | 33.75 | 9.81 | 67 | 134773 | 7481 | 50462803 |
Traumatic coma | 33.73 | 9.81 | 11 | 134829 | 61 | 50470223 |
Blood creatinine increased | 33.64 | 9.81 | 98 | 134742 | 76062 | 50394222 |
Hallucination, visual | 33.63 | 9.81 | 109 | 134731 | 16473 | 50453811 |
Oculogyric crisis | 33.55 | 9.81 | 29 | 134811 | 1408 | 50468876 |
Speech disorder | 32.93 | 9.81 | 184 | 134656 | 35364 | 50434920 |
Cardiac failure | 32.75 | 9.81 | 99 | 134741 | 75941 | 50394343 |
Delusion of grandeur | 32.42 | 9.81 | 13 | 134827 | 140 | 50470144 |
Neuropathy peripheral | 32.38 | 9.81 | 140 | 134700 | 96617 | 50373667 |
Ventricular hypokinesia | 32.11 | 9.81 | 46 | 134794 | 3934 | 50466350 |
Major depression | 31.86 | 9.81 | 62 | 134778 | 6822 | 50463462 |
Cytomegalovirus infection | 31.57 | 9.81 | 5 | 134835 | 17957 | 50452327 |
Hypotonia neonatal | 31.48 | 9.81 | 24 | 134816 | 973 | 50469311 |
Mental disorder | 31.41 | 9.81 | 129 | 134711 | 21862 | 50448422 |
Blood prolactin increased | 31.37 | 9.81 | 40 | 134800 | 3059 | 50467225 |
Physical assault | 31.22 | 9.81 | 23 | 134817 | 885 | 50469399 |
Mental impairment | 30.88 | 9.81 | 86 | 134754 | 11958 | 50458326 |
Hypertonia | 30.71 | 9.81 | 45 | 134795 | 3928 | 50466356 |
Herpes zoster | 30.60 | 9.81 | 92 | 134748 | 70694 | 50399590 |
Respiration abnormal | 30.03 | 9.81 | 51 | 134789 | 5051 | 50465233 |
Tachycardia | 29.75 | 9.81 | 401 | 134439 | 99362 | 50370922 |
Psychotic disorder | 29.63 | 9.81 | 126 | 134714 | 21686 | 50448598 |
Acute kidney injury | 29.42 | 9.81 | 429 | 134411 | 227629 | 50242655 |
Hallucination | 29.35 | 9.81 | 219 | 134621 | 46438 | 50423846 |
Arthritis | 29.31 | 9.81 | 125 | 134715 | 86596 | 50383688 |
Loss of libido | 29.20 | 9.81 | 25 | 134815 | 1198 | 50469086 |
Abortion missed | 29.15 | 9.81 | 28 | 134812 | 1560 | 50468724 |
Breech presentation | 29.13 | 9.81 | 24 | 134816 | 1090 | 50469194 |
Inappropriate antidiuretic hormone secretion | 29.04 | 9.81 | 89 | 134751 | 13054 | 50457230 |
Fear | 28.93 | 9.81 | 95 | 134745 | 14454 | 50455830 |
Soft tissue injury | 28.83 | 9.81 | 27 | 134813 | 1457 | 50468827 |
Unresponsive to stimuli | 28.73 | 9.81 | 159 | 134681 | 30450 | 50439834 |
Dysarthria | 28.51 | 9.81 | 184 | 134656 | 37219 | 50433065 |
Catatonia | 28.42 | 9.81 | 42 | 134798 | 3694 | 50466590 |
Accidental overdose | 28.23 | 9.81 | 115 | 134725 | 19418 | 50450866 |
Antipsychotic drug level increased | 28.17 | 9.81 | 38 | 134802 | 3071 | 50467213 |
Erythema | 28.06 | 9.81 | 252 | 134588 | 146162 | 50324122 |
Talipes | 27.99 | 9.81 | 26 | 134814 | 1388 | 50468896 |
Pleural effusion | 27.78 | 9.81 | 117 | 134723 | 81337 | 50388947 |
Lethargy | 27.77 | 9.81 | 226 | 134614 | 49206 | 50421078 |
Stress | 27.60 | 9.81 | 241 | 134599 | 53552 | 50416732 |
Burning mouth syndrome | 27.58 | 9.81 | 16 | 134824 | 407 | 50469877 |
Sternal fracture | 27.15 | 9.81 | 30 | 134810 | 1972 | 50468312 |
Affect lability | 26.87 | 9.81 | 68 | 134772 | 8930 | 50461354 |
Neoplasm progression | 26.71 | 9.81 | 23 | 134817 | 29134 | 50441150 |
Migraine | 26.46 | 9.81 | 312 | 134528 | 74968 | 50395316 |
Pulmonary valve stenosis | 26.07 | 9.81 | 14 | 134826 | 305 | 50469979 |
Injury | 26.05 | 9.81 | 221 | 134619 | 48704 | 50421580 |
White blood cell count decreased | 25.98 | 9.81 | 193 | 134647 | 116529 | 50353755 |
Flat affect | 25.84 | 9.81 | 24 | 134816 | 1281 | 50469003 |
Fatigue | 25.66 | 9.81 | 1585 | 133255 | 706016 | 49764268 |
Blood lactate dehydrogenase increased | 25.62 | 9.81 | 10 | 134830 | 19552 | 50450732 |
Panic reaction | 25.55 | 9.81 | 39 | 134801 | 3530 | 50466754 |
Bulimia nervosa | 25.49 | 9.81 | 15 | 134825 | 392 | 50469892 |
Urinary incontinence | 25.46 | 9.81 | 145 | 134695 | 28063 | 50442221 |
Reduced facial expression | 25.36 | 9.81 | 26 | 134814 | 1568 | 50468716 |
Inflammation | 25.30 | 9.81 | 73 | 134767 | 56839 | 50413445 |
Haemoglobin decreased | 25.24 | 9.81 | 217 | 134623 | 126999 | 50343285 |
Alcoholism | 25.01 | 9.81 | 26 | 134814 | 1594 | 50468690 |
Multiple sclerosis relapse | 24.98 | 9.81 | 198 | 134642 | 42766 | 50427518 |
Septic shock | 24.93 | 9.81 | 74 | 134766 | 57101 | 50413183 |
Attention-seeking behaviour | 24.90 | 9.81 | 9 | 134831 | 71 | 50470213 |
Poor quality sleep | 24.85 | 9.81 | 99 | 134741 | 16547 | 50453737 |
Protein C increased | 24.83 | 9.81 | 10 | 134830 | 109 | 50470175 |
Red blood cell sedimentation rate increased | 24.82 | 9.81 | 25 | 134815 | 29391 | 50440893 |
Weight increased | 24.81 | 9.81 | 709 | 134131 | 201182 | 50269102 |
Drug abuser | 24.77 | 9.81 | 34 | 134806 | 2794 | 50467490 |
Marital problem | 24.73 | 9.81 | 11 | 134829 | 156 | 50470128 |
Pulmonary haemosiderosis | 24.65 | 9.81 | 5 | 134835 | 0 | 50470284 |
Agoraphobia | 24.60 | 9.81 | 14 | 134826 | 343 | 50469941 |
Persistent foetal circulation | 24.51 | 9.81 | 12 | 134828 | 214 | 50470070 |
Disinhibition | 24.49 | 9.81 | 19 | 134821 | 791 | 50469493 |
Posture abnormal | 24.44 | 9.81 | 29 | 134811 | 2060 | 50468224 |
Depression suicidal | 24.43 | 9.81 | 25 | 134815 | 1504 | 50468780 |
Drug level increased | 24.42 | 9.81 | 109 | 134731 | 19159 | 50451125 |
Trichotillomania | 24.28 | 9.81 | 10 | 134830 | 116 | 50470168 |
Heart sounds | 24.04 | 9.81 | 17 | 134823 | 613 | 50469671 |
Musculoskeletal pain | 23.80 | 9.81 | 105 | 134735 | 72072 | 50398212 |
Irritable bowel syndrome | 23.59 | 9.81 | 65 | 134775 | 51376 | 50418908 |
Sinus tachycardia | 23.54 | 9.81 | 116 | 134724 | 21238 | 50449046 |
Food interaction | 23.42 | 9.81 | 17 | 134823 | 639 | 50469645 |
Dysphoria | 23.33 | 9.81 | 44 | 134796 | 4730 | 50465554 |
Thinking abnormal | 23.24 | 9.81 | 67 | 134773 | 9500 | 50460784 |
Self esteem decreased | 23.22 | 9.81 | 16 | 134824 | 553 | 50469731 |
Heart rate | 22.60 | 9.81 | 8 | 134832 | 59 | 50470225 |
Hypothermia | 22.60 | 9.81 | 77 | 134763 | 11939 | 50458345 |
Pulmonary valve stenosis congenital | 22.41 | 9.81 | 10 | 134830 | 143 | 50470141 |
Narcolepsy | 22.33 | 9.81 | 21 | 134819 | 1139 | 50469145 |
Concussion | 22.11 | 9.81 | 57 | 134783 | 7571 | 50462713 |
Metabolic acidosis | 22.07 | 9.81 | 178 | 134662 | 38647 | 50431637 |
Prolonged expiration | 21.99 | 9.81 | 17 | 134823 | 704 | 50469580 |
Respiratory disorder neonatal | 21.99 | 9.81 | 19 | 134821 | 922 | 50469362 |
Hyperthermia | 21.78 | 9.81 | 57 | 134783 | 7639 | 50462645 |
Diet failure | 21.74 | 9.81 | 7 | 134833 | 37 | 50470247 |
Sepsis | 21.62 | 9.81 | 238 | 134602 | 132687 | 50337597 |
Gallbladder disorder | 21.43 | 9.81 | 95 | 134745 | 16647 | 50453637 |
Psychomotor retardation | 21.23 | 9.81 | 35 | 134805 | 3383 | 50466901 |
Neonatal complications of substance abuse | 21.20 | 9.81 | 5 | 134835 | 5 | 50470279 |
Infantile apnoea | 21.16 | 9.81 | 18 | 134822 | 855 | 50469429 |
Induced abortion failed | 21.15 | 9.81 | 11 | 134829 | 224 | 50470060 |
Myelosuppression | 21.15 | 9.81 | 5 | 134835 | 13512 | 50456772 |
Eye movement disorder | 21.11 | 9.81 | 41 | 134799 | 4504 | 50465780 |
Bipolar I disorder | 21.02 | 9.81 | 23 | 134817 | 1495 | 50468789 |
Emotional poverty | 20.83 | 9.81 | 12 | 134828 | 301 | 50469983 |
Dissociation | 20.76 | 9.81 | 28 | 134812 | 2263 | 50468021 |
Neonatal hypoxia | 20.70 | 9.81 | 14 | 134826 | 469 | 50469815 |
Eating disorder symptom | 20.53 | 9.81 | 9 | 134831 | 123 | 50470161 |
Borderline personality disorder | 20.50 | 9.81 | 16 | 134824 | 672 | 50469612 |
CYP3A4 polymorphism | 20.47 | 9.81 | 8 | 134832 | 80 | 50470204 |
Disorientation | 20.34 | 9.81 | 163 | 134677 | 35321 | 50434963 |
Brugada syndrome | 20.24 | 9.81 | 12 | 134828 | 318 | 50469966 |
Aortic bruit | 19.99 | 9.81 | 6 | 134834 | 24 | 50470260 |
Tongue biting | 19.91 | 9.81 | 21 | 134819 | 1309 | 50468975 |
Gestational diabetes | 19.83 | 9.81 | 54 | 134786 | 7411 | 50462873 |
Drug use disorder | 19.82 | 9.81 | 32 | 134808 | 3040 | 50467244 |
IIIrd nerve paresis | 19.78 | 9.81 | 9 | 134831 | 135 | 50470149 |
Posterior segment of eye anomaly congenital | 19.72 | 9.81 | 4 | 134836 | 0 | 50470284 |
Leukocytosis | 19.68 | 9.81 | 115 | 134725 | 22464 | 50447820 |
Feeling jittery | 19.67 | 9.81 | 70 | 134770 | 11090 | 50459194 |
Patent ductus arteriosus | 19.66 | 9.81 | 36 | 134804 | 3784 | 50466500 |
Dizziness | 19.44 | 9.81 | 1118 | 133722 | 345251 | 50125033 |
Procedural hypertension | 19.38 | 9.81 | 11 | 134829 | 268 | 50470016 |
Small for dates baby | 19.27 | 9.81 | 34 | 134806 | 3471 | 50466813 |
Slow response to stimuli | 19.21 | 9.81 | 17 | 134823 | 852 | 50469432 |
Dysphemia | 19.11 | 9.81 | 27 | 134813 | 2279 | 50468005 |
Joint range of motion decreased | 19.00 | 9.81 | 13 | 134827 | 18499 | 50451785 |
Hypomania | 18.96 | 9.81 | 39 | 134801 | 4466 | 50465818 |
Neonatal asphyxia | 18.95 | 9.81 | 10 | 134830 | 210 | 50470074 |
Sleep-related eating disorder | 18.95 | 9.81 | 16 | 134824 | 752 | 50469532 |
Posterior reversible encephalopathy syndrome | 18.95 | 9.81 | 8 | 134832 | 14920 | 50455364 |
Ventricular tachycardia | 18.93 | 9.81 | 88 | 134752 | 15733 | 50454551 |
Homicidal ideation | 18.88 | 9.81 | 23 | 134817 | 1679 | 50468605 |
Drug eruption | 18.87 | 9.81 | 21 | 134819 | 23585 | 50446699 |
Primitive reflex test positive | 18.87 | 9.81 | 5 | 134835 | 11 | 50470273 |
Optic ischaemic neuropathy | 18.79 | 9.81 | 18 | 134822 | 999 | 50469285 |
Electrolyte depletion | 18.77 | 9.81 | 9 | 134831 | 153 | 50470131 |
Ideas of reference | 18.75 | 9.81 | 8 | 134832 | 102 | 50470182 |
Road traffic accident | 18.68 | 9.81 | 120 | 134720 | 24232 | 50446052 |
Developmental delay | 18.61 | 9.81 | 20 | 134820 | 1274 | 50469010 |
Constipation | 18.51 | 9.81 | 366 | 134474 | 185342 | 50284942 |
Gastric bypass | 18.44 | 9.81 | 21 | 134819 | 1427 | 50468857 |
Post-traumatic neck syndrome | 18.31 | 9.81 | 24 | 134816 | 1886 | 50468398 |
Spinal shock | 18.28 | 9.81 | 5 | 134835 | 13 | 50470271 |
Osteonecrosis of jaw | 18.18 | 9.81 | 37 | 134803 | 32489 | 50437795 |
Gaze palsy | 18.12 | 9.81 | 20 | 134820 | 1313 | 50468971 |
Maternal exposure during pregnancy | 18.08 | 9.81 | 308 | 134532 | 159470 | 50310814 |
Anterograde amnesia | 17.90 | 9.81 | 13 | 134827 | 489 | 50469795 |
Psychomotor hyperactivity | 17.84 | 9.81 | 60 | 134780 | 9241 | 50461043 |
Blood pressure measurement | 17.79 | 9.81 | 10 | 134830 | 239 | 50470045 |
Heart disease congenital | 17.72 | 9.81 | 19 | 134821 | 1207 | 50469077 |
Somnambulism | 17.71 | 9.81 | 40 | 134800 | 4884 | 50465400 |
Blood pressure systolic increased | 17.63 | 9.81 | 43 | 134797 | 35406 | 50434878 |
Atelectasis neonatal | 17.52 | 9.81 | 5 | 134835 | 16 | 50470268 |
pH body fluid increased | 17.49 | 9.81 | 4 | 134836 | 3 | 50470281 |
Oppositional defiant disorder | 17.47 | 9.81 | 6 | 134834 | 40 | 50470244 |
Drug screen positive | 17.43 | 9.81 | 32 | 134808 | 3370 | 50466914 |
Loss of consciousness | 17.42 | 9.81 | 382 | 134458 | 103971 | 50366313 |
Bruxism | 17.38 | 9.81 | 30 | 134810 | 3010 | 50467274 |
Drug hypersensitivity | 17.28 | 9.81 | 523 | 134317 | 250487 | 50219797 |
Neuroleptic malignant syndrome | 17.27 | 9.81 | 67 | 134773 | 11063 | 50459221 |
Atrioventricular block second degree | 17.23 | 9.81 | 33 | 134807 | 3588 | 50466696 |
Sudden onset of sleep | 17.23 | 9.81 | 13 | 134827 | 519 | 50469765 |
Personality change | 17.21 | 9.81 | 43 | 134797 | 5602 | 50464682 |
Disturbance in sexual arousal | 17.16 | 9.81 | 7 | 134833 | 79 | 50470205 |
Liver function test increased | 17.15 | 9.81 | 26 | 134814 | 25580 | 50444704 |
Prolonged labour | 16.97 | 9.81 | 13 | 134827 | 531 | 50469753 |
Cholecystectomy | 16.96 | 9.81 | 59 | 134781 | 9244 | 50461040 |
Supraventricular tachyarrhythmia | 16.86 | 9.81 | 7 | 134833 | 83 | 50470201 |
Balance disorder | 16.82 | 9.81 | 273 | 134567 | 70317 | 50399967 |
Acute respiratory distress syndrome | 16.82 | 9.81 | 105 | 134735 | 20994 | 50449290 |
Influenza like illness | 16.73 | 9.81 | 230 | 134610 | 57229 | 50413055 |
Chronic fatigue syndrome | 16.68 | 9.81 | 17 | 134823 | 1018 | 50469266 |
Energy increased | 16.68 | 9.81 | 25 | 134815 | 2227 | 50468057 |
Hallucinations, mixed | 16.66 | 9.81 | 35 | 134805 | 4068 | 50466216 |
Pruritus | 16.65 | 9.81 | 603 | 134237 | 282965 | 50187319 |
Congenital brain damage | 16.49 | 9.81 | 4 | 134836 | 5 | 50470279 |
Hyperkalaemia | 16.44 | 9.81 | 69 | 134771 | 48020 | 50422264 |
Nervousness | 16.39 | 9.81 | 128 | 134712 | 27523 | 50442761 |
Affective disorder | 16.36 | 9.81 | 40 | 134800 | 5141 | 50465143 |
Serum sickness-like reaction | 16.35 | 9.81 | 12 | 134828 | 459 | 50469825 |
Hypercalcaemia | 16.34 | 9.81 | 23 | 134817 | 23329 | 50446955 |
Prolonged rupture of membranes | 16.31 | 9.81 | 6 | 134834 | 50 | 50470234 |
Regurgitation | 16.27 | 9.81 | 19 | 134821 | 1327 | 50468957 |
Placenta praevia | 16.09 | 9.81 | 16 | 134824 | 930 | 50469354 |
Hypersomnia | 16.04 | 9.81 | 82 | 134758 | 15232 | 50455052 |
Withdrawal catatonia | 16.01 | 9.81 | 6 | 134834 | 53 | 50470231 |
Palmar-plantar erythrodysaesthesia syndrome | 15.93 | 9.81 | 18 | 134822 | 20080 | 50450204 |
Agonal rhythm | 15.93 | 9.81 | 5 | 134835 | 24 | 50470260 |
Pulmonary vasculitis | 15.91 | 9.81 | 6 | 134834 | 54 | 50470230 |
Blunted affect | 15.87 | 9.81 | 9 | 134831 | 219 | 50470065 |
Accidental exposure to product | 15.84 | 9.81 | 23 | 134817 | 23034 | 50447250 |
Emotional disorder | 15.79 | 9.81 | 68 | 134772 | 11768 | 50458516 |
Eosinophilic pneumonia acute | 15.76 | 9.81 | 10 | 134830 | 300 | 50469984 |
Tachyphrenia | 15.76 | 9.81 | 18 | 134822 | 1227 | 50469057 |
Loss of bladder sensation | 15.76 | 9.81 | 5 | 134835 | 25 | 50470259 |
Polydactyly | 15.73 | 9.81 | 10 | 134830 | 301 | 50469983 |
Libido decreased | 15.67 | 9.81 | 25 | 134815 | 2351 | 50467933 |
Nystagmus | 15.55 | 9.81 | 41 | 134799 | 5520 | 50464764 |
Obsessive thoughts | 15.52 | 9.81 | 12 | 134828 | 497 | 50469787 |
Paraesthesia | 15.51 | 9.81 | 425 | 134415 | 119818 | 50350466 |
Breast enlargement | 15.50 | 9.81 | 19 | 134821 | 1396 | 50468888 |
Analgesic drug level increased | 15.45 | 9.81 | 21 | 134819 | 1710 | 50468574 |
Breast discomfort | 15.43 | 9.81 | 11 | 134829 | 402 | 50469882 |
Toxic epidermal necrolysis | 15.37 | 9.81 | 20 | 134820 | 20972 | 50449312 |
Alcohol withdrawal syndrome | 15.37 | 9.81 | 14 | 134826 | 729 | 50469555 |
Fluid retention | 15.33 | 9.81 | 76 | 134764 | 50573 | 50419711 |
Hepatic function abnormal | 15.21 | 9.81 | 41 | 134799 | 32640 | 50437644 |
Plasma cell mastitis | 15.15 | 9.81 | 5 | 134835 | 29 | 50470255 |
Phobia | 15.14 | 9.81 | 10 | 134830 | 322 | 50469962 |
Sleep paralysis | 15.05 | 9.81 | 12 | 134828 | 520 | 50469764 |
Psoriasis | 15.03 | 9.81 | 263 | 134577 | 68737 | 50401547 |
Tooth hypoplasia | 14.93 | 9.81 | 6 | 134834 | 65 | 50470219 |
Acute myeloid leukaemia | 14.92 | 9.81 | 11 | 134829 | 15063 | 50455221 |
Intrusive thoughts | 14.91 | 9.81 | 8 | 134832 | 174 | 50470110 |
Oesophageal food impaction | 14.91 | 9.81 | 8 | 134832 | 174 | 50470110 |
Staring | 14.88 | 9.81 | 19 | 134821 | 1455 | 50468829 |
Leukopenia | 14.85 | 9.81 | 112 | 134728 | 67416 | 50402868 |
Parkinsonian gait | 14.76 | 9.81 | 11 | 134829 | 431 | 50469853 |
Formication | 14.69 | 9.81 | 31 | 134809 | 3615 | 50466669 |
Polyneuropathy | 14.62 | 9.81 | 7 | 134833 | 12124 | 50458160 |
Alcohol use | 14.57 | 9.81 | 22 | 134818 | 1973 | 50468311 |
Skin ulcer | 14.48 | 9.81 | 47 | 134793 | 35271 | 50435013 |
Peritonitis | 14.45 | 9.81 | 12 | 134828 | 15474 | 50454810 |
Chemical burn | 14.38 | 9.81 | 10 | 134830 | 351 | 50469933 |
Feeling of despair | 14.37 | 9.81 | 22 | 134818 | 1996 | 50468288 |
Umbilical cord around neck | 14.28 | 9.81 | 8 | 134832 | 190 | 50470094 |
Psychotic behaviour | 14.27 | 9.81 | 12 | 134828 | 561 | 50469723 |
Microcephaly | 14.25 | 9.81 | 14 | 134826 | 802 | 50469482 |
Device placement issue | 14.25 | 9.81 | 14 | 134826 | 802 | 50469482 |
Bipolar disorder | 14.23 | 9.81 | 45 | 134795 | 6712 | 50463572 |
Hypoprolactinaemia | 14.21 | 9.81 | 4 | 134836 | 12 | 50470272 |
Hyporesponsive to stimuli | 14.20 | 9.81 | 15 | 134825 | 937 | 50469347 |
Transplant rejection | 14.18 | 9.81 | 4 | 134836 | 9605 | 50460679 |
Bradykinesia | 14.15 | 9.81 | 32 | 134808 | 3911 | 50466373 |
Cleft palate | 14.05 | 9.81 | 15 | 134825 | 948 | 50469336 |
Gait disturbance | 14.03 | 9.81 | 510 | 134330 | 149495 | 50320789 |
Decreased interest | 14.01 | 9.81 | 27 | 134813 | 2949 | 50467335 |
Cold agglutinins positive | 13.99 | 9.81 | 5 | 134835 | 38 | 50470246 |
Muscle enzyme increased | 13.99 | 9.81 | 7 | 134833 | 131 | 50470153 |
Congenital multiplex arthrogryposis | 13.97 | 9.81 | 4 | 134836 | 13 | 50470271 |
Mononucleosis syndrome | 13.90 | 9.81 | 7 | 134833 | 133 | 50470151 |
Transient aphasia | 13.88 | 9.81 | 5 | 134835 | 39 | 50470245 |
Hypnopompic hallucination | 13.88 | 9.81 | 5 | 134835 | 39 | 50470245 |
Sluggishness | 13.86 | 9.81 | 34 | 134806 | 4379 | 50465905 |
Pre-existing condition improved | 13.80 | 9.81 | 46 | 134794 | 7051 | 50463233 |
Purple glove syndrome | 13.74 | 9.81 | 8 | 134832 | 205 | 50470079 |
Anhedonia | 13.71 | 9.81 | 56 | 134784 | 9468 | 50460816 |
Bone erosion | 13.70 | 9.81 | 7 | 134833 | 11680 | 50458604 |
Coordination abnormal | 13.68 | 9.81 | 64 | 134776 | 11470 | 50458814 |
Basilar migraine | 13.67 | 9.81 | 5 | 134835 | 41 | 50470243 |
Brucellosis | 13.67 | 9.81 | 5 | 134835 | 41 | 50470243 |
Cholelithiasis | 13.61 | 9.81 | 158 | 134682 | 37815 | 50432469 |
Pericardial effusion | 13.56 | 9.81 | 30 | 134810 | 25559 | 50444725 |
Floppy infant | 13.56 | 9.81 | 6 | 134834 | 84 | 50470200 |
Negative thoughts | 13.55 | 9.81 | 14 | 134826 | 852 | 50469432 |
Hypouricaemia | 13.53 | 9.81 | 7 | 134833 | 141 | 50470143 |
Binge eating | 13.52 | 9.81 | 10 | 134830 | 387 | 50469897 |
Hospitalisation | 13.41 | 9.81 | 116 | 134724 | 67821 | 50402463 |
Post-traumatic stress disorder | 13.35 | 9.81 | 33 | 134807 | 4270 | 50466014 |
Sudden cardiac death | 13.35 | 9.81 | 21 | 134819 | 1951 | 50468333 |
Back pain | 13.34 | 9.81 | 466 | 134374 | 219564 | 50250720 |
Dermatillomania | 13.23 | 9.81 | 7 | 134833 | 148 | 50470136 |
Drug tolerance decreased | 13.17 | 9.81 | 4 | 134836 | 9156 | 50461128 |
Ventricular arrhythmia | 13.17 | 9.81 | 28 | 134812 | 3281 | 50467003 |
Amenorrhoea | 13.10 | 9.81 | 51 | 134789 | 8433 | 50461851 |
Biliary dyskinesia | 13.08 | 9.81 | 24 | 134816 | 2526 | 50467758 |
Device related infection | 13.00 | 9.81 | 22 | 134818 | 20713 | 50449571 |
Feeling guilty | 12.99 | 9.81 | 11 | 134829 | 519 | 50469765 |
Depersonalisation/derealisation disorder | 12.98 | 9.81 | 16 | 134824 | 1182 | 50469102 |
Tension | 12.93 | 9.81 | 25 | 134815 | 2737 | 50467547 |
General physical condition abnormal | 12.93 | 9.81 | 29 | 134811 | 3524 | 50466760 |
Sensation of blood flow | 12.89 | 9.81 | 5 | 134835 | 49 | 50470235 |
Amaurosis | 12.81 | 9.81 | 11 | 134829 | 529 | 50469755 |
Heavy menstrual bleeding | 12.81 | 9.81 | 78 | 134762 | 15459 | 50454825 |
Cataplexy | 12.80 | 9.81 | 15 | 134825 | 1051 | 50469233 |
Jaw clicking | 12.78 | 9.81 | 4 | 134836 | 19 | 50470265 |
Pregnancy with advanced maternal age | 12.72 | 9.81 | 3 | 134837 | 3 | 50470281 |
Potentiating drug interaction | 12.63 | 9.81 | 30 | 134810 | 3786 | 50466498 |
Platelet dysfunction | 12.62 | 9.81 | 6 | 134834 | 100 | 50470184 |
Oesophageal adenocarcinoma | 12.62 | 9.81 | 7 | 134833 | 163 | 50470121 |
Craniosynostosis | 12.58 | 9.81 | 7 | 134833 | 164 | 50470120 |
Therapeutic response decreased | 12.56 | 9.81 | 74 | 134766 | 47157 | 50423127 |
Ascites | 12.54 | 9.81 | 51 | 134789 | 35810 | 50434474 |
Hypoxic-ischaemic encephalopathy | 12.49 | 9.81 | 30 | 134810 | 3812 | 50466472 |
Fear of weight gain | 12.45 | 9.81 | 4 | 134836 | 21 | 50470263 |
Neonatal disorder | 12.43 | 9.81 | 11 | 134829 | 551 | 50469733 |
Gastrointestinal haemorrhage | 12.43 | 9.81 | 130 | 134710 | 73191 | 50397093 |
Feeling drunk | 12.40 | 9.81 | 29 | 134811 | 3624 | 50466660 |
Liver disorder | 12.36 | 9.81 | 54 | 134786 | 37168 | 50433116 |
Thrombotic microangiopathy | 12.36 | 9.81 | 4 | 134836 | 8787 | 50461497 |
Metastases to bone | 12.32 | 9.81 | 18 | 134822 | 17977 | 50452307 |
Duodenal ulcer repair | 12.29 | 9.81 | 5 | 134835 | 56 | 50470228 |
Panic disorder | 12.23 | 9.81 | 22 | 134818 | 2281 | 50468003 |
Appetite disorder | 12.22 | 9.81 | 40 | 134800 | 6074 | 50464210 |
Personality disorder | 12.21 | 9.81 | 32 | 134808 | 4292 | 50465992 |
Blood bilirubin increased | 12.21 | 9.81 | 44 | 134796 | 31994 | 50438290 |
Haematotoxicity | 12.20 | 9.81 | 3 | 134837 | 7892 | 50462392 |
Incubator therapy | 12.15 | 9.81 | 4 | 134836 | 23 | 50470261 |
Medical diet | 12.15 | 9.81 | 4 | 134836 | 23 | 50470261 |
Skin infection | 12.13 | 9.81 | 9 | 134831 | 12282 | 50458002 |
Bradycardia neonatal | 12.03 | 9.81 | 13 | 134827 | 833 | 50469451 |
Ketonuria | 11.99 | 9.81 | 10 | 134830 | 462 | 50469822 |
Pleurothotonus | 11.94 | 9.81 | 16 | 134824 | 1285 | 50468999 |
Infantile vomiting | 11.87 | 9.81 | 6 | 134834 | 115 | 50470169 |
Anorexia nervosa | 11.83 | 9.81 | 7 | 134833 | 185 | 50470099 |
Panniculitis | 11.72 | 9.81 | 4 | 134836 | 8499 | 50461785 |
Anal incontinence | 11.67 | 9.81 | 61 | 134779 | 11429 | 50458855 |
Areflexia | 11.62 | 9.81 | 24 | 134816 | 2756 | 50467528 |
Antidepressant drug level above therapeutic | 11.61 | 9.81 | 9 | 134831 | 374 | 50469910 |
Osteoporosis | 11.58 | 9.81 | 71 | 134769 | 44808 | 50425476 |
Oxygen saturation decreased | 11.57 | 9.81 | 132 | 134708 | 73116 | 50397168 |
Social avoidant behaviour | 11.52 | 9.81 | 24 | 134816 | 2773 | 50467511 |
Carotid arterial embolus | 11.51 | 9.81 | 3 | 134837 | 6 | 50470278 |
Renal adenoma | 11.51 | 9.81 | 3 | 134837 | 6 | 50470278 |
Hyperinsulinism | 11.51 | 9.81 | 3 | 134837 | 6 | 50470278 |
Ventricular septal defect | 11.51 | 9.81 | 30 | 134810 | 4011 | 50466273 |
Myasthenic syndrome | 11.50 | 9.81 | 7 | 134833 | 195 | 50470089 |
Job dissatisfaction | 11.48 | 9.81 | 4 | 134836 | 28 | 50470256 |
Gambling disorder | 11.44 | 9.81 | 15 | 134825 | 1179 | 50469105 |
Tenosynovitis | 11.41 | 9.81 | 7 | 134833 | 10558 | 50459726 |
Joint hyperextension | 11.35 | 9.81 | 8 | 134832 | 287 | 50469997 |
Creatinine renal clearance decreased | 11.34 | 9.81 | 9 | 134831 | 11872 | 50458412 |
Economic problem | 11.33 | 9.81 | 19 | 134821 | 1863 | 50468421 |
Confabulation | 11.32 | 9.81 | 8 | 134832 | 288 | 50469996 |
Product use in unapproved indication | 11.31 | 9.81 | 229 | 134611 | 115590 | 50354694 |
Sleep disorder | 11.31 | 9.81 | 215 | 134625 | 57068 | 50413216 |
Theft | 11.30 | 9.81 | 5 | 134835 | 70 | 50470214 |
Hypnagogic hallucination | 11.29 | 9.81 | 6 | 134834 | 128 | 50470156 |
Foetal arrhythmia | 11.29 | 9.81 | 6 | 134834 | 128 | 50470156 |
Pulmonary valve incompetence | 11.26 | 9.81 | 15 | 134825 | 1198 | 50469086 |
Social anxiety disorder | 11.25 | 9.81 | 9 | 134831 | 392 | 50469892 |
Neonatal respiratory distress | 11.23 | 9.81 | 8 | 134832 | 292 | 50469992 |
Fall | 11.20 | 9.81 | 1037 | 133803 | 333895 | 50136389 |
Spina bifida occulta | 11.20 | 9.81 | 3 | 134837 | 7 | 50470277 |
Unmasking of previously unidentified disease | 11.14 | 9.81 | 12 | 134828 | 766 | 50469518 |
Lymphocytic hypophysitis | 11.12 | 9.81 | 7 | 134833 | 207 | 50470077 |
Substance abuse | 11.12 | 9.81 | 30 | 134810 | 4094 | 50466190 |
Hypometabolism | 11.02 | 9.81 | 4 | 134836 | 32 | 50470252 |
Injection site pain | 11.00 | 9.81 | 219 | 134621 | 110805 | 50359479 |
Yawning | 10.99 | 9.81 | 13 | 134827 | 920 | 50469364 |
Acute stress disorder | 10.98 | 9.81 | 7 | 134833 | 212 | 50470072 |
Proteinuria | 10.97 | 9.81 | 17 | 134823 | 16580 | 50453704 |
Postural tremor | 10.92 | 9.81 | 7 | 134833 | 214 | 50470070 |
Dissociative identity disorder | 10.87 | 9.81 | 5 | 134835 | 77 | 50470207 |
Neutropenic sepsis | 10.86 | 9.81 | 13 | 134827 | 14134 | 50456150 |
Death of relative | 10.83 | 9.81 | 7 | 134833 | 217 | 50470067 |
Apgar score low | 10.79 | 9.81 | 11 | 134829 | 659 | 50469625 |
Spasmodic dysphonia | 10.76 | 9.81 | 5 | 134835 | 79 | 50470205 |
Complication of device insertion | 10.74 | 9.81 | 38 | 134802 | 6003 | 50464281 |
Jaundice neonatal | 10.73 | 9.81 | 12 | 134828 | 799 | 50469485 |
Pregnancy on oral contraceptive | 10.72 | 9.81 | 13 | 134827 | 945 | 50469339 |
Pleural disorder | 10.70 | 9.81 | 10 | 134830 | 538 | 50469746 |
Cytopenia | 10.67 | 9.81 | 5 | 134835 | 8770 | 50461514 |
Thought insertion | 10.66 | 9.81 | 3 | 134837 | 9 | 50470275 |
Tooth demineralisation | 10.66 | 9.81 | 3 | 134837 | 9 | 50470275 |
Dysmorphism | 10.62 | 9.81 | 20 | 134820 | 2147 | 50468137 |
Muscle neoplasm | 10.61 | 9.81 | 4 | 134836 | 36 | 50470248 |
Obsessive-compulsive symptom | 10.61 | 9.81 | 4 | 134836 | 36 | 50470248 |
Dermatitis atopic | 10.60 | 9.81 | 27 | 134813 | 3559 | 50466725 |
Enthesopathy | 10.60 | 9.81 | 3 | 134837 | 7190 | 50463094 |
Sleep attacks | 10.59 | 9.81 | 5 | 134835 | 82 | 50470202 |
Respiratory disorder | 10.50 | 9.81 | 45 | 134795 | 31142 | 50439142 |
Diverticulitis | 10.50 | 9.81 | 49 | 134791 | 33133 | 50437151 |
Lactation disorder | 10.46 | 9.81 | 8 | 134832 | 326 | 50469958 |
Autonomic nervous system imbalance | 10.46 | 9.81 | 21 | 134819 | 2364 | 50467920 |
Antisocial personality disorder | 10.42 | 9.81 | 3 | 134837 | 10 | 50470274 |
Oedema peripheral | 10.40 | 9.81 | 331 | 134509 | 157630 | 50312654 |
Hypertonic bladder | 10.38 | 9.81 | 24 | 134816 | 2976 | 50467308 |
Superior mesenteric artery syndrome | 10.37 | 9.81 | 5 | 134835 | 86 | 50470198 |
Multiple organ dysfunction syndrome | 10.36 | 9.81 | 85 | 134755 | 50252 | 50420032 |
Blood pressure diastolic decreased | 10.34 | 9.81 | 18 | 134822 | 16763 | 50453521 |
Gallbladder neoplasm | 10.33 | 9.81 | 4 | 134836 | 39 | 50470245 |
Bacteraemia | 10.31 | 9.81 | 14 | 134826 | 14419 | 50455865 |
Extensor plantar response | 10.30 | 9.81 | 14 | 134826 | 1140 | 50469144 |
Dental restoration failure | 10.29 | 9.81 | 10 | 134830 | 565 | 50469719 |
Neutrophil count decreased | 10.28 | 9.81 | 76 | 134764 | 45950 | 50424334 |
Pyloric stenosis | 10.27 | 9.81 | 8 | 134832 | 335 | 50469949 |
Lymphatic system neoplasm | 10.24 | 9.81 | 4 | 134836 | 40 | 50470244 |
Pulmonary artery stenosis congenital | 10.23 | 9.81 | 7 | 134833 | 239 | 50470045 |
Metastases to central nervous system | 10.21 | 9.81 | 9 | 134831 | 11273 | 50459011 |
Treatment noncompliance | 10.17 | 9.81 | 124 | 134716 | 30026 | 50440258 |
Blood triglycerides increased | 10.11 | 9.81 | 58 | 134782 | 11254 | 50459030 |
Embolism | 10.10 | 9.81 | 3 | 134837 | 6965 | 50463319 |
Asthenia | 10.08 | 9.81 | 723 | 134117 | 318319 | 50151965 |
Apnoea | 10.06 | 9.81 | 41 | 134799 | 6925 | 50463359 |
Multiple allergies | 10.02 | 9.81 | 5 | 134835 | 8458 | 50461826 |
Joint effusion | 9.96 | 9.81 | 12 | 134828 | 13009 | 50457275 |
Productive cough | 9.95 | 9.81 | 91 | 134749 | 52603 | 50417681 |
Blood urea increased | 9.94 | 9.81 | 31 | 134809 | 23554 | 50446730 |
Micturition urgency | 9.91 | 9.81 | 46 | 134794 | 8218 | 50462066 |
Haemorrhage intracranial | 9.90 | 9.81 | 11 | 134829 | 12363 | 50457921 |
Electrocardiogram repolarisation abnormality | 9.87 | 9.81 | 14 | 134826 | 1186 | 50469098 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Serotonin syndrome | 878.30 | 10.68 | 502 | 57794 | 17010 | 29499221 |
Suicidal ideation | 418.86 | 10.68 | 424 | 57872 | 34292 | 29481939 |
Completed suicide | 376.01 | 10.68 | 653 | 57643 | 89593 | 29426638 |
Toxicity to various agents | 349.86 | 10.68 | 935 | 57361 | 172726 | 29343505 |
Suicide attempt | 339.30 | 10.68 | 376 | 57920 | 33734 | 29482497 |
Intentional overdose | 305.38 | 10.68 | 378 | 57918 | 38150 | 29478081 |
Drug interaction | 260.66 | 10.68 | 917 | 57379 | 196468 | 29319763 |
Obsessive-compulsive disorder | 244.87 | 10.68 | 137 | 58159 | 4439 | 29511792 |
Akathisia | 210.18 | 10.68 | 143 | 58153 | 6599 | 29509632 |
Anxiety | 181.83 | 10.68 | 470 | 57826 | 84895 | 29431336 |
Euphoric mood | 159.16 | 10.68 | 106 | 58190 | 4719 | 29511512 |
Agitation | 155.98 | 10.68 | 325 | 57971 | 50979 | 29465252 |
Aggression | 153.96 | 10.68 | 262 | 58034 | 35279 | 29480952 |
Overdose | 144.44 | 10.68 | 414 | 57882 | 79405 | 29436826 |
Drug abuse | 140.37 | 10.68 | 410 | 57886 | 79473 | 29436758 |
Antipsychotic drug level below therapeutic | 139.11 | 10.68 | 71 | 58225 | 1903 | 29514328 |
Drug withdrawal syndrome | 133.69 | 10.68 | 171 | 58125 | 17813 | 29498418 |
Therapeutic product effect variable | 127.90 | 10.68 | 66 | 58230 | 1811 | 29514420 |
Depression | 125.44 | 10.68 | 411 | 57885 | 84736 | 29431495 |
Homicide | 123.91 | 10.68 | 52 | 58244 | 876 | 29515355 |
Disinhibition | 123.25 | 10.68 | 72 | 58224 | 2535 | 29513696 |
Febrile neutropenia | 113.11 | 10.68 | 40 | 58256 | 112200 | 29404031 |
Increased appetite | 109.81 | 10.68 | 93 | 58203 | 5971 | 29510260 |
Pneumonia | 93.25 | 10.68 | 322 | 57974 | 319850 | 29196381 |
Electrocardiogram QT prolonged | 92.82 | 10.68 | 214 | 58082 | 35923 | 29480308 |
Psychotic disorder | 86.72 | 10.68 | 149 | 58147 | 20205 | 29496026 |
Depressed mood | 85.83 | 10.68 | 132 | 58164 | 16316 | 29499915 |
Drug dependence | 84.72 | 10.68 | 150 | 58146 | 20831 | 29495400 |
Pyrexia | 79.87 | 10.68 | 295 | 58001 | 287327 | 29228904 |
Irritability | 78.88 | 10.68 | 150 | 58146 | 22002 | 29494229 |
Paranoia | 78.29 | 10.68 | 97 | 58199 | 9780 | 29506451 |
Anaemia | 75.33 | 10.68 | 179 | 58117 | 200772 | 29315459 |
Sepsis | 75.06 | 10.68 | 103 | 58193 | 142579 | 29373652 |
Malignant neoplasm progression | 74.92 | 10.68 | 26 | 58270 | 73833 | 29442398 |
Exposure during pregnancy | 74.31 | 10.68 | 88 | 58208 | 8466 | 29507765 |
Poisoning | 71.09 | 10.68 | 93 | 58203 | 9900 | 29506331 |
Obesity | 70.49 | 10.68 | 92 | 58204 | 9771 | 29506460 |
Mania | 68.54 | 10.68 | 85 | 58211 | 8578 | 29507653 |
Intentional self-injury | 66.42 | 10.68 | 101 | 58195 | 12360 | 29503871 |
Suicidal behaviour | 65.32 | 10.68 | 38 | 58258 | 1327 | 29514904 |
Intentional product misuse | 63.77 | 10.68 | 181 | 58115 | 34480 | 29481751 |
Tardive dyskinesia | 62.90 | 10.68 | 64 | 58232 | 5194 | 29511037 |
Thrombocytopenia | 62.55 | 10.68 | 106 | 58190 | 134717 | 29381514 |
Tremor | 59.05 | 10.68 | 294 | 58002 | 73244 | 29442987 |
Anger | 57.66 | 10.68 | 88 | 58208 | 10802 | 29505429 |
Platelet count decreased | 57.63 | 10.68 | 73 | 58223 | 104599 | 29411632 |
Drug withdrawal syndrome neonatal | 57.26 | 10.68 | 50 | 58246 | 3345 | 29512886 |
Weight increased | 57.02 | 10.68 | 300 | 57996 | 76367 | 29439864 |
Victim of child abuse | 55.53 | 10.68 | 29 | 58267 | 816 | 29515415 |
Sedation | 54.87 | 10.68 | 112 | 58184 | 17293 | 29498938 |
Muscle twitching | 54.48 | 10.68 | 73 | 58223 | 7953 | 29508278 |
Hyperreflexia | 53.26 | 10.68 | 44 | 58252 | 2728 | 29513503 |
Social avoidant behaviour | 53.02 | 10.68 | 45 | 58251 | 2897 | 29513334 |
Abnormal behaviour | 52.93 | 10.68 | 131 | 58165 | 22996 | 29493235 |
Disease progression | 51.80 | 10.68 | 51 | 58245 | 81865 | 29434366 |
Dyskinesia | 50.60 | 10.68 | 118 | 58178 | 19943 | 29496288 |
Diarrhoea | 50.49 | 10.68 | 417 | 57879 | 332281 | 29183950 |
Sexual dysfunction | 49.16 | 10.68 | 59 | 58237 | 5755 | 29510476 |
Hallucination, auditory | 48.66 | 10.68 | 76 | 58220 | 9517 | 29506714 |
Tic | 48.06 | 10.68 | 35 | 58261 | 1800 | 29514431 |
Disturbance in attention | 47.61 | 10.68 | 120 | 58176 | 21304 | 29494927 |
Synaesthesia | 47.08 | 10.68 | 9 | 58287 | 0 | 29516231 |
Parasomnia | 47.01 | 10.68 | 20 | 58276 | 349 | 29515882 |
General physical health deterioration | 45.74 | 10.68 | 83 | 58213 | 102774 | 29413457 |
Haemoglobin decreased | 45.10 | 10.68 | 91 | 58205 | 108284 | 29407947 |
Nightmare | 42.73 | 10.68 | 79 | 58217 | 11338 | 29504893 |
Withdrawal syndrome | 42.33 | 10.68 | 77 | 58219 | 10915 | 29505316 |
Extrapyramidal disorder | 41.87 | 10.68 | 76 | 58220 | 10755 | 29505476 |
Mental disorder | 41.81 | 10.68 | 84 | 58212 | 12821 | 29503410 |
Pancytopenia | 41.74 | 10.68 | 62 | 58234 | 83106 | 29433125 |
Atrial fibrillation | 41.20 | 10.68 | 92 | 58204 | 105554 | 29410677 |
Myoclonus | 41.19 | 10.68 | 85 | 58211 | 13224 | 29503007 |
Bipolar disorder | 41.05 | 10.68 | 41 | 58255 | 3254 | 29512977 |
Visceral congestion | 40.89 | 10.68 | 20 | 58276 | 488 | 29515743 |
Renal impairment | 40.46 | 10.68 | 61 | 58235 | 81272 | 29434959 |
Tremor neonatal | 40.44 | 10.68 | 18 | 58278 | 352 | 29515879 |
Antipsychotic drug level increased | 39.75 | 10.68 | 40 | 58256 | 3203 | 29513028 |
Insomnia | 39.61 | 10.68 | 305 | 57991 | 88456 | 29427775 |
Panic attack | 39.53 | 10.68 | 64 | 58232 | 8262 | 29507969 |
Hepatic function abnormal | 39.48 | 10.68 | 14 | 58282 | 39245 | 29476986 |
Drug abuser | 39.40 | 10.68 | 43 | 58253 | 3784 | 29512447 |
Infection | 38.73 | 10.68 | 57 | 58239 | 76694 | 29439537 |
Asphyxia | 38.63 | 10.68 | 50 | 58246 | 5265 | 29510966 |
Depersonalisation/derealisation disorder | 38.35 | 10.68 | 20 | 58276 | 561 | 29515670 |
Homicidal ideation | 38.26 | 10.68 | 35 | 58261 | 2489 | 29513742 |
Prescribed overdose | 37.54 | 10.68 | 64 | 58232 | 8619 | 29507612 |
Rash | 37.53 | 10.68 | 220 | 58076 | 189599 | 29326632 |
Thinking abnormal | 36.11 | 10.68 | 48 | 58248 | 5188 | 29511043 |
Chorea | 35.89 | 10.68 | 23 | 58273 | 958 | 29515273 |
Maternal drugs affecting foetus | 35.39 | 10.68 | 41 | 58255 | 3852 | 29512379 |
Blood prolactin increased | 35.14 | 10.68 | 27 | 58269 | 1507 | 29514724 |
Delusion | 35.14 | 10.68 | 72 | 58224 | 11144 | 29505087 |
Somnolence | 35.03 | 10.68 | 310 | 57986 | 93645 | 29422586 |
Hyperhidrosis | 34.71 | 10.68 | 232 | 58064 | 64308 | 29451923 |
Neutropenia | 33.91 | 10.68 | 139 | 58157 | 131572 | 29384659 |
Abnormal sleep-related event | 33.88 | 10.68 | 17 | 58279 | 439 | 29515792 |
Acute kidney injury | 33.87 | 10.68 | 347 | 57949 | 264920 | 29251311 |
Mast cell activation syndrome | 33.76 | 10.68 | 13 | 58283 | 173 | 29516058 |
Seizure | 33.05 | 10.68 | 304 | 57992 | 92819 | 29423412 |
Apathy | 32.85 | 10.68 | 50 | 58246 | 6121 | 29510110 |
Bone marrow failure | 32.81 | 10.68 | 7 | 58289 | 27442 | 29488789 |
Torsade de pointes | 32.71 | 10.68 | 52 | 58244 | 6609 | 29509622 |
Respiratory depression | 32.43 | 10.68 | 78 | 58218 | 13445 | 29502786 |
Generalised tonic-clonic seizure | 32.36 | 10.68 | 97 | 58199 | 19042 | 29497189 |
Priapism | 32.28 | 10.68 | 42 | 58254 | 4446 | 29511785 |
Mucosal inflammation | 32.23 | 10.68 | 11 | 58285 | 31584 | 29484647 |
Affective disorder | 31.96 | 10.68 | 35 | 58261 | 3091 | 29513140 |
Product complaint | 31.95 | 10.68 | 46 | 58250 | 5359 | 29510872 |
Tearfulness | 31.50 | 10.68 | 26 | 58270 | 1610 | 29514621 |
Stomatitis | 31.37 | 10.68 | 17 | 58279 | 37096 | 29479135 |
Neuroleptic malignant syndrome | 31.33 | 10.68 | 86 | 58210 | 16062 | 29500169 |
Nervousness | 31.29 | 10.68 | 69 | 58227 | 11237 | 29504994 |
Restless legs syndrome | 30.89 | 10.68 | 52 | 58244 | 6932 | 29509299 |
Mood swings | 30.76 | 10.68 | 53 | 58243 | 7198 | 29509033 |
Dyslipidaemia | 30.71 | 10.68 | 48 | 58248 | 6013 | 29510218 |
Dissociation | 30.63 | 10.68 | 22 | 58274 | 1107 | 29515124 |
Social anxiety disorder | 30.60 | 10.68 | 13 | 58283 | 226 | 29516005 |
Oral discharge | 30.53 | 10.68 | 11 | 58285 | 120 | 29516111 |
Choreoathetosis | 30.28 | 10.68 | 21 | 58275 | 999 | 29515232 |
Sleep disorder | 30.00 | 10.68 | 111 | 58185 | 24275 | 29491956 |
Rhabdomyolysis | 29.98 | 10.68 | 214 | 58082 | 60594 | 29455637 |
Poisoning deliberate | 29.90 | 10.68 | 46 | 58250 | 5685 | 29510546 |
Cytomegalovirus infection | 29.71 | 10.68 | 5 | 58291 | 23210 | 29493021 |
Major depression | 29.33 | 10.68 | 37 | 58259 | 3798 | 29512433 |
Septic shock | 29.14 | 10.68 | 49 | 58247 | 62511 | 29453720 |
Persistent foetal circulation | 29.10 | 10.68 | 14 | 58282 | 329 | 29515902 |
Antidepressant drug level increased | 28.89 | 10.68 | 10 | 58286 | 96 | 29516135 |
Memory impairment | 28.67 | 10.68 | 145 | 58151 | 36325 | 29479906 |
Abnormal dreams | 28.60 | 10.68 | 50 | 58246 | 6870 | 29509361 |
Hallucination | 28.57 | 10.68 | 168 | 58128 | 44544 | 29471687 |
Bruxism | 28.03 | 10.68 | 24 | 58272 | 1563 | 29514668 |
Huntington's disease | 27.76 | 10.68 | 8 | 58288 | 39 | 29516192 |
Serum ferritin abnormal | 27.67 | 10.68 | 12 | 58284 | 220 | 29516011 |
Impulsive behaviour | 27.63 | 10.68 | 26 | 58270 | 1917 | 29514314 |
Libido decreased | 27.51 | 10.68 | 38 | 58258 | 4260 | 29511971 |
Derealisation | 27.39 | 10.68 | 16 | 58280 | 563 | 29515668 |
Congenital aortic valve stenosis | 26.82 | 10.68 | 10 | 58286 | 121 | 29516110 |
Rheumatoid arthritis | 26.78 | 10.68 | 15 | 58281 | 32137 | 29484094 |
Clonus | 26.74 | 10.68 | 28 | 58268 | 2350 | 29513881 |
Coma | 26.35 | 10.68 | 150 | 58146 | 39300 | 29476931 |
Interstitial lung disease | 26.16 | 10.68 | 46 | 58250 | 57672 | 29458559 |
Alcoholism | 25.84 | 10.68 | 29 | 58267 | 2632 | 29513599 |
Accidental death | 25.73 | 10.68 | 26 | 58270 | 2092 | 29514139 |
Cyanosis neonatal | 25.46 | 10.68 | 12 | 58284 | 269 | 29515962 |
Gastrointestinal haemorrhage | 25.08 | 10.68 | 77 | 58219 | 79456 | 29436775 |
Neonatal disorder | 24.94 | 10.68 | 17 | 58279 | 786 | 29515445 |
Accommodation disorder | 24.91 | 10.68 | 11 | 58285 | 211 | 29516020 |
Oculogyric crisis | 24.90 | 10.68 | 21 | 58275 | 1340 | 29514891 |
Initial insomnia | 24.85 | 10.68 | 29 | 58267 | 2746 | 29513485 |
Foetal exposure during pregnancy | 24.78 | 10.68 | 132 | 58164 | 33735 | 29482496 |
Renal failure | 24.73 | 10.68 | 135 | 58161 | 118464 | 29397767 |
Respiratory failure | 24.67 | 10.68 | 103 | 58193 | 97028 | 29419203 |
Schizoaffective disorder | 24.53 | 10.68 | 19 | 58277 | 1073 | 29515158 |
Antisocial behaviour | 24.38 | 10.68 | 12 | 58284 | 297 | 29515934 |
Epidural lipomatosis | 24.36 | 10.68 | 16 | 58280 | 695 | 29515536 |
Gambling disorder | 24.19 | 10.68 | 22 | 58274 | 1553 | 29514678 |
Violence-related symptom | 23.96 | 10.68 | 14 | 58282 | 493 | 29515738 |
Alcohol poisoning | 23.94 | 10.68 | 30 | 58266 | 3059 | 29513172 |
Dreamy state | 23.90 | 10.68 | 6 | 58290 | 15 | 29516216 |
Hyperdynamic left ventricle | 23.77 | 10.68 | 9 | 58287 | 114 | 29516117 |
Hyperkalaemia | 23.48 | 10.68 | 54 | 58242 | 61338 | 29454893 |
Cardiac failure | 23.44 | 10.68 | 79 | 58217 | 79208 | 29437023 |
Restlessness | 23.33 | 10.68 | 96 | 58200 | 22049 | 29494182 |
Treatment failure | 23.33 | 10.68 | 23 | 58273 | 36916 | 29479315 |
Pleural effusion | 23.11 | 10.68 | 69 | 58227 | 71839 | 29444392 |
Feeling jittery | 23.07 | 10.68 | 32 | 58264 | 3601 | 29512630 |
Vasoplegia syndrome | 23.03 | 10.68 | 21 | 58275 | 1487 | 29514744 |
Neuropathy peripheral | 22.94 | 10.68 | 68 | 58228 | 70959 | 29445272 |
Electrocardiogram QRS complex prolonged | 22.87 | 10.68 | 34 | 58262 | 4076 | 29512155 |
Eye movement disorder | 22.65 | 10.68 | 32 | 58264 | 3664 | 29512567 |
Juvenile idiopathic arthritis | 22.45 | 10.68 | 20 | 58276 | 1374 | 29514857 |
Hostility | 22.35 | 10.68 | 16 | 58280 | 801 | 29515430 |
Herpes zoster | 22.31 | 10.68 | 16 | 58280 | 30036 | 29486195 |
Pulmonary embolism | 22.12 | 10.68 | 77 | 58219 | 76457 | 29439774 |
Cardiac arrest | 22.11 | 10.68 | 262 | 58034 | 85329 | 29430902 |
Disseminated intravascular coagulation | 22.10 | 10.68 | 6 | 58290 | 19974 | 29496257 |
Product substitution issue | 22.09 | 10.68 | 53 | 58243 | 9119 | 29507112 |
Mood altered | 21.88 | 10.68 | 49 | 58247 | 8062 | 29508169 |
Myocardial infarction | 21.67 | 10.68 | 128 | 58168 | 110168 | 29406063 |
Blunted affect | 21.34 | 10.68 | 11 | 58285 | 301 | 29515930 |
Obsessive thoughts | 21.32 | 10.68 | 14 | 58282 | 608 | 29515623 |
Muscle rigidity | 21.20 | 10.68 | 53 | 58243 | 9358 | 29506873 |
Serum serotonin decreased | 20.93 | 10.68 | 4 | 58292 | 0 | 29516231 |
Parkinsonism | 20.80 | 10.68 | 45 | 58251 | 7233 | 29508998 |
Flat affect | 20.50 | 10.68 | 15 | 58281 | 777 | 29515454 |
Neonatal respiratory distress syndrome | 20.47 | 10.68 | 31 | 58265 | 3779 | 29512452 |
Off label use | 20.40 | 10.68 | 445 | 57851 | 300355 | 29215876 |
Vascular stenosis | 20.36 | 10.68 | 9 | 58287 | 173 | 29516058 |
White blood cell count decreased | 20.19 | 10.68 | 90 | 58206 | 83272 | 29432959 |
Lethargy | 20.13 | 10.68 | 135 | 58161 | 37445 | 29478786 |
Dystonia | 20.00 | 10.68 | 53 | 58243 | 9696 | 29506535 |
Compulsions | 19.99 | 10.68 | 9 | 58287 | 181 | 29516050 |
Poor quality sleep | 19.85 | 10.68 | 44 | 58252 | 7189 | 29509042 |
Respiratory arrest | 19.80 | 10.68 | 102 | 58194 | 25731 | 29490500 |
Hypersomnia | 19.61 | 10.68 | 56 | 58240 | 10698 | 29505533 |
Emotional disorder | 19.57 | 10.68 | 35 | 58261 | 4896 | 29511335 |
Drug level increased | 19.44 | 10.68 | 81 | 58215 | 18706 | 29497525 |
Cholinergic syndrome | 19.29 | 10.68 | 12 | 58284 | 474 | 29515757 |
Psychomotor hyperactivity | 19.29 | 10.68 | 47 | 58249 | 8166 | 29508065 |
Loss of employment | 19.27 | 10.68 | 12 | 58284 | 475 | 29515756 |
Yawning | 19.20 | 10.68 | 12 | 58284 | 478 | 29515753 |
Compulsive shopping | 18.94 | 10.68 | 11 | 58285 | 383 | 29515848 |
Hypoglycaemia neonatal | 18.85 | 10.68 | 20 | 58276 | 1704 | 29514527 |
Negative thoughts | 18.83 | 10.68 | 13 | 58283 | 614 | 29515617 |
Self-injurious ideation | 18.77 | 10.68 | 19 | 58277 | 1532 | 29514699 |
Agitation neonatal | 18.72 | 10.68 | 16 | 58280 | 1040 | 29515191 |
Erythema | 18.69 | 10.68 | 81 | 58215 | 75525 | 29440706 |
Dyspnoea | 18.68 | 10.68 | 496 | 57800 | 326236 | 29189995 |
Pneumocystis jirovecii pneumonia | 18.63 | 10.68 | 5 | 58291 | 16774 | 29499457 |
Compulsive hoarding | 18.56 | 10.68 | 5 | 58291 | 18 | 29516213 |
Peripheral swelling | 18.50 | 10.68 | 64 | 58232 | 63675 | 29452556 |
Physical deconditioning | 18.45 | 10.68 | 14 | 58282 | 767 | 29515464 |
Pituitary tumour benign | 18.37 | 10.68 | 14 | 58282 | 772 | 29515459 |
Somnambulism | 18.30 | 10.68 | 25 | 58271 | 2773 | 29513458 |
Congenital aortic valve incompetence | 18.28 | 10.68 | 8 | 58288 | 150 | 29516081 |
Premature baby | 18.28 | 10.68 | 75 | 58221 | 17205 | 29499026 |
Renal ischaemia | 18.20 | 10.68 | 12 | 58284 | 525 | 29515706 |
Retinal phototoxicity | 18.16 | 10.68 | 4 | 58292 | 4 | 29516227 |
Infusion related reaction | 18.10 | 10.68 | 37 | 58259 | 43849 | 29472382 |
Schizophrenia | 18.09 | 10.68 | 40 | 58256 | 6525 | 29509706 |
Chronic actinic dermatitis | 17.95 | 10.68 | 5 | 58291 | 21 | 29516210 |
COVID-19 | 17.91 | 10.68 | 27 | 58269 | 35987 | 29480244 |
Mydriasis | 17.82 | 10.68 | 38 | 58258 | 6047 | 29510184 |
Leukaemia | 17.69 | 10.68 | 29 | 58267 | 3781 | 29512450 |
Small for dates baby | 17.66 | 10.68 | 28 | 58268 | 3551 | 29512680 |
Arthralgia | 17.61 | 10.68 | 183 | 58113 | 139434 | 29376797 |
Lymphocyte count decreased | 17.53 | 10.68 | 8 | 58288 | 19263 | 29496968 |
Cognitive disorder | 17.47 | 10.68 | 92 | 58204 | 23407 | 29492824 |
Loss of libido | 17.32 | 10.68 | 22 | 58274 | 2274 | 29513957 |
Tachyphrenia | 17.31 | 10.68 | 16 | 58280 | 1153 | 29515078 |
Urinary tract discomfort | 17.18 | 10.68 | 7 | 58289 | 109 | 29516122 |
Colitis | 16.96 | 10.68 | 22 | 58274 | 31226 | 29485005 |
Pain | 16.93 | 10.68 | 237 | 58059 | 171195 | 29345036 |
Ascites | 16.75 | 10.68 | 29 | 58267 | 36590 | 29479641 |
Blood cholesterol increased | 16.74 | 10.68 | 68 | 58228 | 15527 | 29500704 |
Liver disorder | 16.70 | 10.68 | 18 | 58278 | 27731 | 29488500 |
Coagulation factor VII level decreased | 16.67 | 10.68 | 7 | 58289 | 118 | 29516113 |
Neoplasm progression | 16.51 | 10.68 | 8 | 58288 | 18604 | 29497627 |
Condition aggravated | 16.51 | 10.68 | 391 | 57905 | 145904 | 29370327 |
Secondary hypogonadism | 16.50 | 10.68 | 9 | 58287 | 277 | 29515954 |
Anaphylactic reaction | 16.47 | 10.68 | 18 | 58278 | 27555 | 29488676 |
Testis cancer | 16.43 | 10.68 | 14 | 58282 | 906 | 29515325 |
Selective mutism | 16.29 | 10.68 | 6 | 58290 | 70 | 29516161 |
Renal artery thrombosis | 16.24 | 10.68 | 9 | 58287 | 286 | 29515945 |
Alcohol use | 16.14 | 10.68 | 25 | 58271 | 3107 | 29513124 |
Tourette's disorder | 16.14 | 10.68 | 6 | 58290 | 72 | 29516159 |
C-reactive protein increased | 16.07 | 10.68 | 40 | 58256 | 44223 | 29472008 |
Cough | 16.02 | 10.68 | 166 | 58130 | 126561 | 29389670 |
Cerebral infarction | 16.00 | 10.68 | 15 | 58281 | 24660 | 29491571 |
Dissociative disorder | 16.00 | 10.68 | 8 | 58288 | 205 | 29516026 |
Muscle necrosis | 15.87 | 10.68 | 13 | 58283 | 796 | 29515435 |
Dysphoria | 15.71 | 10.68 | 20 | 58276 | 2072 | 29514159 |
Tumour lysis syndrome | 15.68 | 10.68 | 4 | 58292 | 13880 | 29502351 |
Basilar migraine | 15.66 | 10.68 | 4 | 58292 | 11 | 29516220 |
Pupil fixed | 15.65 | 10.68 | 18 | 58278 | 1678 | 29514553 |
Feeling guilty | 15.55 | 10.68 | 9 | 58287 | 311 | 29515920 |
Haematochezia | 15.41 | 10.68 | 31 | 58265 | 36952 | 29479279 |
Child abuse | 15.39 | 10.68 | 8 | 58288 | 223 | 29516008 |
Decreased interest | 15.36 | 10.68 | 20 | 58276 | 2118 | 29514113 |
Neutrophil count decreased | 15.33 | 10.68 | 40 | 58256 | 43527 | 29472704 |
Hepatic failure | 15.31 | 10.68 | 24 | 58272 | 31488 | 29484743 |
Palmar-plantar erythrodysaesthesia syndrome | 15.29 | 10.68 | 5 | 58291 | 14754 | 29501477 |
Autonomic nervous system imbalance | 15.20 | 10.68 | 21 | 58275 | 2355 | 29513876 |
Phobia | 15.14 | 10.68 | 7 | 58289 | 150 | 29516081 |
Erectile dysfunction | 15.14 | 10.68 | 73 | 58223 | 17936 | 29498295 |
Coma uraemic | 15.04 | 10.68 | 5 | 58291 | 42 | 29516189 |
Congenital hand malformation | 15.03 | 10.68 | 11 | 58285 | 570 | 29515661 |
Obsessive-compulsive symptom | 14.93 | 10.68 | 6 | 58290 | 90 | 29516141 |
Salivary hypersecretion | 14.91 | 10.68 | 40 | 58256 | 7369 | 29508862 |
Transposition of the great vessels | 14.91 | 10.68 | 10 | 58286 | 450 | 29515781 |
Miosis | 14.89 | 10.68 | 42 | 58254 | 7967 | 29508264 |
Blood glucose fluctuation | 14.88 | 10.68 | 26 | 58270 | 3571 | 29512660 |
Hyperbilirubinaemia neonatal | 14.72 | 10.68 | 12 | 58284 | 730 | 29515501 |
Spina bifida | 14.71 | 10.68 | 9 | 58287 | 345 | 29515886 |
Exposure via ingestion | 14.69 | 10.68 | 19 | 58277 | 1999 | 29514232 |
Bipolar I disorder | 14.68 | 10.68 | 12 | 58284 | 733 | 29515498 |
Ear discomfort | 14.65 | 10.68 | 20 | 58276 | 2217 | 29514014 |
Feeling abnormal | 14.64 | 10.68 | 168 | 58128 | 54277 | 29461954 |
Pyloric stenosis | 14.61 | 10.68 | 12 | 58284 | 738 | 29515493 |
Eye colour change | 14.53 | 10.68 | 8 | 58288 | 251 | 29515980 |
Post 5-alpha-reductase inhibitor syndrome | 14.46 | 10.68 | 6 | 58290 | 98 | 29516133 |
Dysphemia | 14.42 | 10.68 | 16 | 58280 | 1434 | 29514797 |
Cerebrovascular stenosis | 14.35 | 10.68 | 6 | 58290 | 100 | 29516131 |
Joint swelling | 14.29 | 10.68 | 50 | 58246 | 49580 | 29466651 |
Tongue injury | 14.25 | 10.68 | 6 | 58290 | 102 | 29516129 |
Hypogonadism male | 14.21 | 10.68 | 8 | 58288 | 262 | 29515969 |
Cataplexy | 14.16 | 10.68 | 8 | 58288 | 264 | 29515967 |
Crying | 14.07 | 10.68 | 32 | 58264 | 5319 | 29510912 |
Tension | 13.91 | 10.68 | 18 | 58278 | 1895 | 29514336 |
Deep vein thrombosis | 13.87 | 10.68 | 62 | 58234 | 57337 | 29458894 |
Death | 13.85 | 10.68 | 543 | 57753 | 341541 | 29174690 |
Myelodysplastic syndrome | 13.84 | 10.68 | 9 | 58287 | 17785 | 29498446 |
Otosalpingitis | 13.80 | 10.68 | 4 | 58292 | 20 | 29516211 |
Faecal calprotectin | 13.80 | 10.68 | 4 | 58292 | 20 | 29516211 |
Alpha 2 globulin decreased | 13.80 | 10.68 | 4 | 58292 | 20 | 29516211 |
Blood luteinising hormone decreased | 13.73 | 10.68 | 6 | 58290 | 112 | 29516119 |
Self-medication | 13.72 | 10.68 | 19 | 58277 | 2135 | 29514096 |
Hypertonia neonatal | 13.70 | 10.68 | 9 | 58287 | 391 | 29515840 |
Tinnitus | 13.64 | 10.68 | 64 | 58232 | 15550 | 29500681 |
Free androgen index decreased | 13.64 | 10.68 | 4 | 58292 | 21 | 29516210 |
Sex hormone binding globulin decreased | 13.64 | 10.68 | 4 | 58292 | 21 | 29516210 |
Blood creatine phosphokinase MB | 13.62 | 10.68 | 3 | 58293 | 3 | 29516228 |
Delayed sleep phase | 13.62 | 10.68 | 3 | 58293 | 3 | 29516228 |
Oedema | 13.62 | 10.68 | 38 | 58258 | 40445 | 29475786 |
Atrial conduction time prolongation | 13.62 | 10.68 | 3 | 58293 | 3 | 29516228 |
Multiple organ dysfunction syndrome | 13.61 | 10.68 | 71 | 58225 | 63045 | 29453186 |
Hypomania | 13.58 | 10.68 | 19 | 58277 | 2156 | 29514075 |
Androgen insensitivity syndrome | 13.48 | 10.68 | 4 | 58292 | 22 | 29516209 |
Viral acanthoma | 13.48 | 10.68 | 4 | 58292 | 22 | 29516209 |
Hospitalisation | 13.46 | 10.68 | 46 | 58250 | 45942 | 29470289 |
Dry mouth | 13.36 | 10.68 | 81 | 58215 | 21703 | 29494528 |
Testicular microlithiasis | 13.19 | 10.68 | 4 | 58292 | 24 | 29516207 |
Fear | 13.18 | 10.68 | 45 | 58251 | 9459 | 29506772 |
Marital problem | 13.16 | 10.68 | 5 | 58291 | 64 | 29516167 |
Blood creatinine increased | 13.13 | 10.68 | 106 | 58190 | 84996 | 29431235 |
Bronchopulmonary aspergillosis | 13.11 | 10.68 | 4 | 58292 | 12340 | 29503891 |
Dehydroepiandrosterone decreased | 13.05 | 10.68 | 4 | 58292 | 25 | 29516206 |
Urine calcium/creatinine ratio increased | 13.05 | 10.68 | 4 | 58292 | 25 | 29516206 |
Blood triglycerides increased | 13.02 | 10.68 | 55 | 58241 | 12779 | 29503452 |
Arnold-Chiari malformation | 12.95 | 10.68 | 8 | 58288 | 312 | 29515919 |
Logorrhoea | 12.84 | 10.68 | 19 | 58277 | 2269 | 29513962 |
Suspected suicide | 12.82 | 10.68 | 26 | 58270 | 3994 | 29512237 |
Retrograde ejaculation | 12.82 | 10.68 | 8 | 58288 | 318 | 29515913 |
Urinary retention | 12.78 | 10.68 | 107 | 58189 | 31791 | 29484440 |
Economic problem | 12.70 | 10.68 | 14 | 58282 | 1246 | 29514985 |
Inflammatory bowel disease | 12.69 | 10.68 | 19 | 58277 | 2292 | 29513939 |
Feeling drunk | 12.64 | 10.68 | 16 | 58280 | 1648 | 29514583 |
Hypothalamic pituitary adrenal axis suppression | 12.59 | 10.68 | 6 | 58290 | 138 | 29516093 |
Confusional state | 12.41 | 10.68 | 335 | 57961 | 127542 | 29388689 |
Thought insertion | 12.41 | 10.68 | 3 | 58293 | 6 | 29516225 |
Alpha globulin increased | 12.41 | 10.68 | 3 | 58293 | 6 | 29516225 |
Chronic kidney disease | 12.39 | 10.68 | 34 | 58262 | 36382 | 29479849 |
Treatment noncompliance | 12.36 | 10.68 | 86 | 58210 | 24141 | 29492090 |
Panic reaction | 12.21 | 10.68 | 14 | 58282 | 1301 | 29514930 |
Blood urea increased | 12.20 | 10.68 | 23 | 58273 | 28089 | 29488142 |
Wrong drug | 12.15 | 10.68 | 5 | 58291 | 80 | 29516151 |
Blood lactate dehydrogenase increased | 12.08 | 10.68 | 12 | 58284 | 19197 | 29497034 |
Pruritus | 12.08 | 10.68 | 160 | 58136 | 116689 | 29399542 |
Therapeutic response unexpected | 12.06 | 10.68 | 41 | 58255 | 8597 | 29507634 |
Locked-in syndrome | 12.04 | 10.68 | 7 | 58289 | 244 | 29515987 |
Atrial septal defect | 12.04 | 10.68 | 35 | 58261 | 6754 | 29509477 |
Blood bilirubin increased | 12.02 | 10.68 | 31 | 58265 | 33862 | 29482369 |
Cardiac failure congestive | 11.99 | 10.68 | 95 | 58201 | 76486 | 29439745 |
Thrombosis | 11.97 | 10.68 | 44 | 58252 | 43001 | 29473230 |
Bone marrow oedema | 11.94 | 10.68 | 9 | 58287 | 488 | 29515743 |
Haemophagocytic lymphohistiocytosis | 11.91 | 10.68 | 3 | 58293 | 10501 | 29505730 |
Prostate cancer | 11.87 | 10.68 | 20 | 58276 | 25507 | 29490724 |
Psychiatric symptom | 11.87 | 10.68 | 22 | 58274 | 3162 | 29513069 |
Cyclothymic disorder | 11.87 | 10.68 | 5 | 58291 | 85 | 29516146 |
Cortisol increased | 11.85 | 10.68 | 6 | 58290 | 158 | 29516073 |
Thyroxine free abnormal | 11.81 | 10.68 | 3 | 58293 | 8 | 29516223 |
Creatinine urine decreased | 11.79 | 10.68 | 4 | 58292 | 36 | 29516195 |
Dermal cyst | 11.77 | 10.68 | 14 | 58282 | 1353 | 29514878 |
Staring | 11.67 | 10.68 | 14 | 58282 | 1365 | 29514866 |
Self esteem decreased | 11.62 | 10.68 | 9 | 58287 | 508 | 29515723 |
Panic disorder | 11.61 | 10.68 | 13 | 58283 | 1177 | 29515054 |
Heart rate abnormal | 11.48 | 10.68 | 15 | 58281 | 1594 | 29514637 |
Candida infection | 11.44 | 10.68 | 8 | 58288 | 15217 | 29501014 |
Galactorrhoea | 11.44 | 10.68 | 8 | 58288 | 386 | 29515845 |
Drooling | 11.42 | 10.68 | 21 | 58275 | 3000 | 29513231 |
Disorientation | 11.29 | 10.68 | 98 | 58198 | 29417 | 29486814 |
Retinopathy of prematurity | 11.22 | 10.68 | 5 | 58291 | 98 | 29516133 |
Sinus tachycardia | 11.20 | 10.68 | 59 | 58237 | 15010 | 29501221 |
Multiple sclerosis | 11.19 | 10.68 | 30 | 58266 | 5524 | 29510707 |
Renal dysplasia | 11.17 | 10.68 | 6 | 58290 | 179 | 29516052 |
Water intoxication | 11.17 | 10.68 | 8 | 58288 | 401 | 29515830 |
Sleep apnoea syndrome | 11.15 | 10.68 | 66 | 58230 | 17533 | 29498698 |
Full blood count abnormal | 11.13 | 10.68 | 8 | 58288 | 15005 | 29501226 |
Carbon monoxide poisoning | 11.13 | 10.68 | 5 | 58291 | 100 | 29516131 |
Terminal insomnia | 11.11 | 10.68 | 8 | 58288 | 404 | 29515827 |
Genital anaesthesia | 11.09 | 10.68 | 3 | 58293 | 11 | 29516220 |
Symptom masked | 11.09 | 10.68 | 9 | 58287 | 544 | 29515687 |
Dyspnoea exertional | 11.02 | 10.68 | 36 | 58260 | 36454 | 29479777 |
Persistent depressive disorder | 10.98 | 10.68 | 7 | 58289 | 289 | 29515942 |
Ankyloglossia congenital | 10.96 | 10.68 | 7 | 58289 | 290 | 29515941 |
Pulmonary congestion | 10.88 | 10.68 | 51 | 58245 | 12385 | 29503846 |
Drug resistance | 10.85 | 10.68 | 16 | 58280 | 21524 | 29494707 |
Urine phosphorus decreased | 10.84 | 10.68 | 4 | 58292 | 47 | 29516184 |
Premature rupture of membranes | 10.70 | 10.68 | 3 | 58293 | 13 | 29516218 |
Drug titration error | 10.69 | 10.68 | 8 | 58288 | 429 | 29515802 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1809.36 | 9.78 | 2443 | 151704 | 221971 | 64122614 |
Serotonin syndrome | 1230.32 | 9.78 | 900 | 153247 | 38382 | 64306203 |
Intentional overdose | 1057.59 | 9.78 | 1186 | 152961 | 88758 | 64255827 |
Toxicity to various agents | 991.23 | 9.78 | 2473 | 151674 | 361040 | 63983545 |
Suicidal ideation | 878.75 | 9.78 | 933 | 153214 | 65609 | 64278976 |
Suicide attempt | 652.29 | 9.78 | 826 | 153321 | 70181 | 64274404 |
Drug interaction | 605.49 | 9.78 | 2070 | 152077 | 360013 | 63984572 |
Drug abuse | 547.15 | 9.78 | 1066 | 153081 | 131308 | 64213277 |
Intentional self-injury | 425.86 | 9.78 | 431 | 153716 | 28613 | 64315972 |
Electrocardiogram QT prolonged | 389.72 | 9.78 | 689 | 153458 | 78759 | 64265826 |
Overdose | 369.16 | 9.78 | 1023 | 153124 | 158543 | 64186042 |
Anxiety | 348.70 | 9.78 | 1171 | 152976 | 201478 | 64143107 |
Agitation | 310.78 | 9.78 | 666 | 153481 | 87701 | 64256884 |
Poisoning | 288.91 | 9.78 | 307 | 153840 | 21572 | 64323013 |
Tremor | 285.98 | 9.78 | 891 | 153256 | 147339 | 64197246 |
Drug withdrawal syndrome | 280.79 | 9.78 | 360 | 153787 | 30931 | 64313654 |
Depression | 275.36 | 9.78 | 1013 | 153134 | 182278 | 64162307 |
Respiratory arrest | 246.29 | 9.78 | 449 | 153698 | 52536 | 64292049 |
Febrile neutropenia | 222.54 | 9.78 | 85 | 154062 | 187572 | 64157013 |
Cardiac arrest | 220.91 | 9.78 | 839 | 153308 | 153225 | 64191360 |
Cardio-respiratory arrest | 209.95 | 9.78 | 613 | 153534 | 97780 | 64246805 |
Akathisia | 206.71 | 9.78 | 191 | 153956 | 11319 | 64333266 |
Withdrawal syndrome | 191.74 | 9.78 | 258 | 153889 | 23234 | 64321351 |
Aggression | 186.67 | 9.78 | 369 | 153778 | 45863 | 64298722 |
Synovitis | 180.59 | 9.78 | 15 | 154132 | 99075 | 64245510 |
Irritability | 176.61 | 9.78 | 316 | 153831 | 36430 | 64308155 |
Suicidal behaviour | 174.30 | 9.78 | 100 | 154047 | 2787 | 64341798 |
Depressed mood | 167.59 | 9.78 | 329 | 153818 | 40683 | 64303902 |
Torsade de pointes | 165.65 | 9.78 | 206 | 153941 | 17157 | 64327428 |
Pneumonia | 164.18 | 9.78 | 734 | 153413 | 558842 | 63785743 |
Contraindicated product administered | 163.35 | 9.78 | 30 | 154117 | 107799 | 64236786 |
Somnolence | 162.16 | 9.78 | 934 | 153213 | 202711 | 64141874 |
Drug intolerance | 160.90 | 9.78 | 128 | 154019 | 187864 | 64156721 |
Reversible cerebral vasoconstriction syndrome | 151.85 | 9.78 | 85 | 154062 | 2257 | 64342328 |
Obsessive-compulsive disorder | 147.55 | 9.78 | 109 | 154038 | 4709 | 64339876 |
Joint swelling | 147.04 | 9.78 | 179 | 153968 | 215203 | 64129382 |
Infusion related reaction | 141.97 | 9.78 | 111 | 154036 | 164356 | 64180229 |
Mania | 139.26 | 9.78 | 183 | 153964 | 16103 | 64328482 |
Rheumatoid arthritis | 136.68 | 9.78 | 115 | 154032 | 164179 | 64180406 |
Anaemia | 132.34 | 9.78 | 463 | 153684 | 378217 | 63966368 |
Nightmare | 130.99 | 9.78 | 203 | 153944 | 20790 | 64323795 |
Hand deformity | 128.08 | 9.78 | 5 | 154142 | 62766 | 64281819 |
Disturbance in attention | 125.69 | 9.78 | 293 | 153854 | 40781 | 64303804 |
Rash | 125.20 | 9.78 | 617 | 153530 | 457932 | 63886653 |
Drug dependence | 125.07 | 9.78 | 258 | 153889 | 33054 | 64311531 |
Pyrexia | 124.27 | 9.78 | 804 | 153343 | 557840 | 63786745 |
Treatment failure | 124.04 | 9.78 | 62 | 154085 | 116754 | 64227831 |
Panic attack | 122.97 | 9.78 | 197 | 153950 | 20756 | 64323829 |
Mydriasis | 120.15 | 9.78 | 165 | 153982 | 15147 | 64329438 |
Respiratory depression | 119.63 | 9.78 | 207 | 153940 | 23236 | 64321349 |
Intentional product misuse | 118.13 | 9.78 | 411 | 153736 | 71884 | 64272701 |
Peripheral swelling | 117.87 | 9.78 | 199 | 153948 | 208954 | 64135631 |
Systemic lupus erythematosus | 114.56 | 9.78 | 23 | 154124 | 77589 | 64266996 |
Infection | 113.59 | 9.78 | 166 | 153981 | 184714 | 64159871 |
Muscle twitching | 112.01 | 9.78 | 179 | 153968 | 18819 | 64325766 |
Coma | 110.05 | 9.78 | 458 | 153689 | 87157 | 64257428 |
Seizure | 109.85 | 9.78 | 729 | 153418 | 166163 | 64178422 |
Thrombocytopenia | 109.38 | 9.78 | 232 | 153915 | 223569 | 64121016 |
Tardive dyskinesia | 109.31 | 9.78 | 122 | 154025 | 9056 | 64335529 |
Neutropenia | 109.28 | 9.78 | 258 | 153889 | 239366 | 64105219 |
Malignant neoplasm progression | 108.18 | 9.78 | 68 | 154079 | 112803 | 64231782 |
Homicide | 106.55 | 9.78 | 53 | 154094 | 1098 | 64343487 |
Poisoning deliberate | 105.56 | 9.78 | 145 | 154002 | 13313 | 64331272 |
Pancytopenia | 105.48 | 9.78 | 112 | 154035 | 143197 | 64201388 |
Platelet count decreased | 102.61 | 9.78 | 151 | 153996 | 167560 | 64177025 |
Pericarditis | 102.32 | 9.78 | 14 | 154133 | 62502 | 64282083 |
Abnormal behaviour | 97.62 | 9.78 | 235 | 153912 | 33387 | 64311198 |
Crying | 96.82 | 9.78 | 173 | 153974 | 19917 | 64324668 |
Paranoia | 94.94 | 9.78 | 153 | 153994 | 16199 | 64328386 |
General physical health deterioration | 94.88 | 9.78 | 218 | 153929 | 204207 | 64140378 |
Sopor | 93.40 | 9.78 | 214 | 153933 | 29447 | 64315138 |
Dystonia | 91.62 | 9.78 | 163 | 153984 | 18702 | 64325883 |
Off label use | 90.22 | 9.78 | 1023 | 153124 | 631783 | 63712802 |
Restless legs syndrome | 89.78 | 9.78 | 153 | 153994 | 16963 | 64327622 |
Self-injurious ideation | 88.30 | 9.78 | 68 | 154079 | 3129 | 64341456 |
Euphoric mood | 87.91 | 9.78 | 93 | 154054 | 6498 | 64338087 |
Myoclonus | 87.85 | 9.78 | 189 | 153958 | 24929 | 64319656 |
Arthralgia | 87.63 | 9.78 | 658 | 153489 | 441602 | 63902983 |
Muscle rigidity | 87.47 | 9.78 | 153 | 153994 | 17320 | 64327265 |
Extrapyramidal disorder | 86.18 | 9.78 | 162 | 153985 | 19390 | 64325195 |
Sedation | 86.15 | 9.78 | 256 | 153891 | 41206 | 64303379 |
Coma scale abnormal | 85.24 | 9.78 | 99 | 154048 | 7675 | 64336910 |
Sepsis | 84.88 | 9.78 | 275 | 153872 | 230066 | 64114519 |
Generalised tonic-clonic seizure | 84.64 | 9.78 | 248 | 153899 | 39609 | 64304976 |
Wound | 83.60 | 9.78 | 39 | 154108 | 76438 | 64268147 |
Swelling | 83.45 | 9.78 | 160 | 153987 | 160058 | 64184527 |
Disease progression | 83.34 | 9.78 | 131 | 154016 | 141549 | 64203036 |
Electrocardiogram QRS complex prolonged | 82.35 | 9.78 | 106 | 154041 | 9138 | 64335447 |
Diarrhoea | 81.82 | 9.78 | 1226 | 152921 | 721478 | 63623107 |
Hyperreflexia | 81.69 | 9.78 | 93 | 154054 | 7055 | 64337530 |
Anger | 81.63 | 9.78 | 140 | 154007 | 15601 | 64328984 |
Tearfulness | 80.93 | 9.78 | 76 | 154071 | 4597 | 64339988 |
Acute kidney injury | 80.85 | 9.78 | 686 | 153461 | 448554 | 63896031 |
Renal impairment | 80.22 | 9.78 | 124 | 154023 | 134893 | 64209692 |
Restlessness | 80.16 | 9.78 | 243 | 153904 | 39542 | 64305043 |
Stomatitis | 79.15 | 9.78 | 87 | 154060 | 109518 | 64235067 |
Psychotic disorder | 79.10 | 9.78 | 221 | 153926 | 34357 | 64310228 |
Atrial fibrillation | 78.13 | 9.78 | 184 | 153963 | 170905 | 64173680 |
Drug ineffective | 78.02 | 9.78 | 1478 | 152669 | 838769 | 63505816 |
Hallucination, auditory | 77.98 | 9.78 | 143 | 154004 | 16796 | 64327789 |
Hyperhidrosis | 77.58 | 9.78 | 538 | 153609 | 124382 | 64220203 |
Tic | 77.40 | 9.78 | 58 | 154089 | 2561 | 64342024 |
Nasopharyngitis | 75.10 | 9.78 | 230 | 153917 | 195843 | 64148742 |
Galactorrhoea | 75.08 | 9.78 | 62 | 154085 | 3157 | 64341428 |
Mucosal inflammation | 74.70 | 9.78 | 28 | 154119 | 62556 | 64282029 |
Hepatic enzyme increased | 74.68 | 9.78 | 122 | 154025 | 129821 | 64214764 |
Arthropathy | 72.91 | 9.78 | 110 | 154037 | 120857 | 64223728 |
Clonus | 72.86 | 9.78 | 81 | 154066 | 5986 | 64338599 |
Dyskinesia | 72.37 | 9.78 | 233 | 153914 | 39155 | 64305430 |
Mood swings | 71.18 | 9.78 | 140 | 154007 | 17328 | 64327257 |
Accidental death | 69.19 | 9.78 | 63 | 154084 | 3662 | 64340923 |
Miosis | 68.81 | 9.78 | 118 | 154029 | 13148 | 64331437 |
Confusional state | 68.18 | 9.78 | 937 | 153210 | 260207 | 64084378 |
Rheumatoid factor positive | 67.37 | 9.78 | 4 | 154143 | 34934 | 64309651 |
Abnormal dreams | 67.22 | 9.78 | 102 | 154045 | 10254 | 64334331 |
Parkinsonism | 67.00 | 9.78 | 122 | 154025 | 14251 | 64330334 |
Insomnia | 66.79 | 9.78 | 745 | 153402 | 197091 | 64147494 |
Alopecia | 65.86 | 9.78 | 191 | 153956 | 165499 | 64179086 |
Impulsive behaviour | 65.71 | 9.78 | 53 | 154094 | 2610 | 64341975 |
Bone marrow failure | 65.19 | 9.78 | 17 | 154130 | 47935 | 64296650 |
Therapeutic product effect decreased | 64.71 | 9.78 | 110 | 154037 | 115241 | 64229344 |
Helicobacter infection | 64.19 | 9.78 | 8 | 154139 | 38354 | 64306231 |
Depressed level of consciousness | 63.07 | 9.78 | 371 | 153776 | 81065 | 64263520 |
Product substitution issue | 62.00 | 9.78 | 134 | 154013 | 17727 | 64326858 |
Cytomegalovirus infection | 61.66 | 9.78 | 8 | 154139 | 37191 | 64307394 |
Memory impairment | 61.06 | 9.78 | 382 | 153765 | 85300 | 64259285 |
Mental disorder | 60.46 | 9.78 | 169 | 153978 | 26276 | 64318309 |
C-reactive protein increased | 58.46 | 9.78 | 85 | 154062 | 94824 | 64249761 |
Disinhibition | 58.25 | 9.78 | 46 | 154101 | 2197 | 64342388 |
Cardiac failure | 57.56 | 9.78 | 146 | 154001 | 132227 | 64212358 |
Drug abuser | 57.15 | 9.78 | 70 | 154077 | 5738 | 64338847 |
Lower respiratory tract infection | 57.05 | 9.78 | 86 | 154061 | 94528 | 64250057 |
Product complaint | 56.40 | 9.78 | 102 | 154045 | 11852 | 64332733 |
Antipsychotic drug level increased | 55.85 | 9.78 | 65 | 154082 | 5050 | 64339535 |
Hallucination | 54.69 | 9.78 | 329 | 153818 | 72459 | 64272126 |
Hostility | 54.62 | 9.78 | 44 | 154103 | 2163 | 64342422 |
Hepatic function abnormal | 53.47 | 9.78 | 45 | 154102 | 64268 | 64280317 |
Social avoidant behaviour | 53.28 | 9.78 | 60 | 154087 | 4497 | 64340088 |
Haemoglobin decreased | 52.77 | 9.78 | 263 | 153884 | 194800 | 64149785 |
Dyspnoea | 52.71 | 9.78 | 1312 | 152835 | 717362 | 63627223 |
Bezoar | 52.58 | 9.78 | 43 | 154104 | 2160 | 64342425 |
Myocardial depression | 52.07 | 9.78 | 25 | 154122 | 478 | 64344107 |
Cough | 51.78 | 9.78 | 467 | 153680 | 301681 | 64042904 |
Septic shock | 51.71 | 9.78 | 109 | 154038 | 105328 | 64239257 |
Glossodynia | 51.69 | 9.78 | 47 | 154100 | 64649 | 64279936 |
Blood creatinine increased | 51.45 | 9.78 | 160 | 153987 | 135622 | 64208963 |
Cholecystitis chronic | 51.34 | 9.78 | 85 | 154062 | 9202 | 64335383 |
Emotional distress | 50.51 | 9.78 | 195 | 153952 | 35843 | 64308742 |
Hypersensitivity | 50.26 | 9.78 | 270 | 153877 | 196182 | 64148403 |
Decorticate posture | 49.52 | 9.78 | 21 | 154126 | 296 | 64344289 |
Victim of child abuse | 49.47 | 9.78 | 29 | 154118 | 842 | 64343743 |
Libido increased | 49.28 | 9.78 | 38 | 154109 | 1752 | 64342833 |
Blood prolactin increased | 49.23 | 9.78 | 51 | 154096 | 3477 | 64341108 |
Abdominal discomfort | 49.21 | 9.78 | 246 | 153901 | 182076 | 64162509 |
Mood altered | 48.89 | 9.78 | 114 | 154033 | 15865 | 64328720 |
Dissociation | 48.40 | 9.78 | 47 | 154100 | 2964 | 64341621 |
Apathy | 48.18 | 9.78 | 92 | 154055 | 11140 | 64333445 |
Herpes zoster | 47.71 | 9.78 | 72 | 154075 | 79115 | 64265470 |
Persistent genital arousal disorder | 47.70 | 9.78 | 19 | 154128 | 226 | 64344359 |
Thinking abnormal | 47.55 | 9.78 | 93 | 154054 | 11463 | 64333122 |
Oculogyric crisis | 47.29 | 9.78 | 43 | 154104 | 2495 | 64342090 |
Erythema | 46.81 | 9.78 | 259 | 153888 | 186811 | 64157774 |
Hyperprolactinaemia | 46.64 | 9.78 | 53 | 154094 | 4012 | 64340573 |
Feeling abnormal | 46.38 | 9.78 | 506 | 153641 | 133096 | 64211489 |
Nervousness | 45.65 | 9.78 | 165 | 153982 | 29391 | 64315194 |
Pleural effusion | 45.26 | 9.78 | 153 | 153994 | 126406 | 64218179 |
Hyperkalaemia | 45.16 | 9.78 | 110 | 154037 | 101019 | 64243566 |
Sleep disorder due to general medical condition, insomnia type | 45.14 | 9.78 | 5 | 154142 | 26265 | 64318320 |
Neuroleptic malignant syndrome | 44.23 | 9.78 | 146 | 154001 | 24850 | 64319735 |
Neuropathy peripheral | 44.16 | 9.78 | 139 | 154008 | 117386 | 64227199 |
Duodenal ulcer perforation | 43.89 | 9.78 | 14 | 154133 | 34611 | 64309974 |
Discomfort | 43.65 | 9.78 | 79 | 154068 | 80799 | 64263786 |
Parasomnia | 43.49 | 9.78 | 22 | 154125 | 473 | 64344112 |
Drug level increased | 43.10 | 9.78 | 179 | 153968 | 34017 | 64310568 |
Cerebral vasoconstriction | 42.81 | 9.78 | 30 | 154117 | 1192 | 64343393 |
Long QT syndrome | 42.78 | 9.78 | 57 | 154090 | 5082 | 64339503 |
C-reactive protein abnormal | 42.05 | 9.78 | 9 | 154138 | 29038 | 64315547 |
Intentional product use issue | 41.59 | 9.78 | 105 | 154042 | 95259 | 64249326 |
Migraine | 41.30 | 9.78 | 274 | 153873 | 62403 | 64282182 |
Poor quality sleep | 41.26 | 9.78 | 119 | 154028 | 18832 | 64325753 |
Blister | 41.14 | 9.78 | 82 | 154065 | 80885 | 64263700 |
Synaesthesia | 40.31 | 9.78 | 8 | 154139 | 0 | 64344585 |
Folliculitis | 40.25 | 9.78 | 11 | 154136 | 30066 | 64314519 |
Blood hyposmosis | 40.14 | 9.78 | 10 | 154137 | 18 | 64344567 |
Homicidal ideation | 40.00 | 9.78 | 44 | 154103 | 3213 | 64341372 |
Alcoholism | 39.97 | 9.78 | 45 | 154102 | 3372 | 64341213 |
Myelosuppression | 39.80 | 9.78 | 5 | 154142 | 23825 | 64320760 |
Anorgasmia | 39.69 | 9.78 | 26 | 154121 | 923 | 64343662 |
Impaired healing | 39.40 | 9.78 | 52 | 154095 | 60421 | 64284164 |
Atrioventricular block first degree | 38.95 | 9.78 | 82 | 154065 | 10652 | 64333933 |
Gastrointestinal disorder | 38.94 | 9.78 | 99 | 154048 | 89610 | 64254975 |
Stress cardiomyopathy | 38.70 | 9.78 | 75 | 154072 | 9182 | 64335403 |
Physical assault | 38.64 | 9.78 | 31 | 154116 | 1515 | 64343070 |
Multiple sclerosis | 38.44 | 9.78 | 116 | 154031 | 18825 | 64325760 |
Morbid thoughts | 38.18 | 9.78 | 23 | 154124 | 703 | 64343882 |
White blood cell count decreased | 38.14 | 9.78 | 221 | 153926 | 157616 | 64186969 |
Reduced facial expression | 37.81 | 9.78 | 35 | 154112 | 2078 | 64342507 |
Neoplasm progression | 37.45 | 9.78 | 26 | 154121 | 40938 | 64303647 |
Dependence | 37.22 | 9.78 | 35 | 154112 | 2120 | 64342465 |
Mobility decreased | 37.05 | 9.78 | 95 | 154052 | 85745 | 64258840 |
Product use issue | 36.89 | 9.78 | 212 | 153935 | 151503 | 64193082 |
Eye movement disorder | 36.75 | 9.78 | 63 | 154084 | 7016 | 64337569 |
Alcohol poisoning | 36.66 | 9.78 | 48 | 154099 | 4207 | 64340378 |
Blood pressure fluctuation | 36.53 | 9.78 | 42 | 154105 | 51829 | 64292756 |
Bruxism | 36.18 | 9.78 | 44 | 154103 | 3580 | 64341005 |
Fear | 35.85 | 9.78 | 118 | 154029 | 20053 | 64324532 |
Speech disorder | 35.77 | 9.78 | 218 | 153929 | 48223 | 64296362 |
Amnesia | 35.50 | 9.78 | 217 | 153930 | 48052 | 64296533 |
Libido decreased | 35.21 | 9.78 | 50 | 154097 | 4734 | 64339851 |
Bipolar I disorder | 34.96 | 9.78 | 31 | 154116 | 1740 | 64342845 |
Muscle injury | 34.76 | 9.78 | 10 | 154137 | 26427 | 64318158 |
Affective disorder | 34.74 | 9.78 | 59 | 154088 | 6521 | 64338064 |
Major depression | 34.74 | 9.78 | 65 | 154082 | 7751 | 64336834 |
Blood lactate dehydrogenase increased | 34.43 | 9.78 | 18 | 154129 | 33060 | 64311525 |
Pain | 34.39 | 9.78 | 1034 | 153113 | 552477 | 63792108 |
Cogwheel rigidity | 34.10 | 9.78 | 38 | 154109 | 2815 | 64341770 |
Flat affect | 33.70 | 9.78 | 31 | 154116 | 1826 | 64342759 |
Obesity | 33.65 | 9.78 | 117 | 154030 | 20445 | 64324140 |
Weight increased | 33.44 | 9.78 | 705 | 153442 | 212643 | 64131942 |
Derealisation | 33.22 | 9.78 | 28 | 154119 | 1467 | 64343118 |
Huntington's disease | 33.01 | 9.78 | 8 | 154139 | 12 | 64344573 |
Traumatic coma | 32.59 | 9.78 | 10 | 154137 | 50 | 64344535 |
Marital problem | 32.41 | 9.78 | 14 | 154133 | 207 | 64344378 |
Ascites | 32.18 | 9.78 | 62 | 154085 | 61939 | 64282646 |
Psychomotor hyperactivity | 31.71 | 9.78 | 91 | 154056 | 14360 | 64330225 |
Increased appetite | 31.71 | 9.78 | 73 | 154074 | 10073 | 64334512 |
Arthritis | 31.57 | 9.78 | 99 | 154048 | 83715 | 64260870 |
Violence-related symptom | 31.43 | 9.78 | 20 | 154127 | 675 | 64343910 |
Mental impairment | 31.22 | 9.78 | 98 | 154049 | 16245 | 64328340 |
Bipolar disorder | 31.02 | 9.78 | 57 | 154090 | 6704 | 64337881 |
Abnormal sleep-related event | 30.93 | 9.78 | 21 | 154126 | 792 | 64343793 |
Hallucination, visual | 30.72 | 9.78 | 140 | 154007 | 27694 | 64316891 |
Sinus bradycardia | 30.56 | 9.78 | 122 | 154025 | 22771 | 64321814 |
Suspected suicide | 30.12 | 9.78 | 65 | 154082 | 8589 | 64335996 |
Inappropriate antidiuretic hormone secretion | 29.93 | 9.78 | 119 | 154028 | 22170 | 64322415 |
Soft tissue injury | 29.91 | 9.78 | 27 | 154120 | 1552 | 64343033 |
Sinus tachycardia | 29.84 | 9.78 | 154 | 153993 | 32034 | 64312551 |
Bradyphrenia | 29.76 | 9.78 | 68 | 154079 | 9338 | 64335247 |
Drug hypersensitivity | 29.73 | 9.78 | 395 | 153752 | 237420 | 64107165 |
Gastrointestinal haemorrhage | 29.48 | 9.78 | 190 | 153957 | 132122 | 64212463 |
Sleep disorder | 29.09 | 9.78 | 243 | 153904 | 59466 | 64285119 |
Delusion | 29.05 | 9.78 | 102 | 154045 | 17912 | 64326673 |
Foetal exposure during pregnancy | 28.93 | 9.78 | 44 | 154103 | 4432 | 64340153 |
Obsessive thoughts | 28.90 | 9.78 | 22 | 154125 | 995 | 64343590 |
Oxygen saturation decreased | 28.68 | 9.78 | 145 | 154002 | 107031 | 64237554 |
Staring | 28.64 | 9.78 | 32 | 154115 | 2378 | 64342207 |
Multiple organ dysfunction syndrome | 28.41 | 9.78 | 135 | 154012 | 101278 | 64243307 |
Visceral congestion | 28.38 | 9.78 | 20 | 154127 | 802 | 64343783 |
Unresponsive to stimuli | 28.34 | 9.78 | 212 | 153935 | 50181 | 64294404 |
Borderline personality disorder | 28.33 | 9.78 | 20 | 154127 | 804 | 64343781 |
Social anxiety disorder | 28.27 | 9.78 | 16 | 154131 | 434 | 64344151 |
Emotional disorder | 28.26 | 9.78 | 80 | 154067 | 12527 | 64332058 |
Transplant rejection | 28.23 | 9.78 | 4 | 154143 | 17397 | 64327188 |
Dysphoria | 28.17 | 9.78 | 43 | 154104 | 4345 | 64340240 |
Panic reaction | 28.05 | 9.78 | 41 | 154106 | 3986 | 64340599 |
Negative thoughts | 27.89 | 9.78 | 24 | 154123 | 1294 | 64343291 |
Hypersomnia | 27.88 | 9.78 | 107 | 154040 | 19610 | 64324975 |
Basilar migraine | 27.83 | 9.78 | 9 | 154138 | 55 | 64344530 |
Blood bilirubin increased | 27.79 | 9.78 | 60 | 154087 | 57493 | 64287092 |
Pulseless electrical activity | 27.74 | 9.78 | 80 | 154067 | 12659 | 64331926 |
Hypomania | 27.64 | 9.78 | 49 | 154098 | 5605 | 64338980 |
Therapeutic product effect incomplete | 27.12 | 9.78 | 141 | 154006 | 103341 | 64241244 |
Depersonalisation/derealisation disorder | 27.12 | 9.78 | 26 | 154121 | 1614 | 64342971 |
Loss of libido | 27.00 | 9.78 | 31 | 154116 | 2373 | 64342212 |
Hyponatraemia | 26.86 | 9.78 | 501 | 153646 | 147838 | 64196747 |
Palmar-plantar erythrodysaesthesia syndrome | 26.73 | 9.78 | 18 | 154129 | 28801 | 64315784 |
Tension | 26.61 | 9.78 | 39 | 154108 | 3801 | 64340784 |
Lethargy | 26.60 | 9.78 | 278 | 153869 | 72316 | 64272269 |
Multiple sclerosis relapse | 26.60 | 9.78 | 179 | 153968 | 40956 | 64303629 |
Carbon monoxide poisoning | 26.59 | 9.78 | 13 | 154134 | 259 | 64344326 |
Dysphemia | 26.59 | 9.78 | 35 | 154112 | 3084 | 64341501 |
Blunted affect | 26.31 | 9.78 | 15 | 154132 | 413 | 64344172 |
Feeling guilty | 26.06 | 9.78 | 19 | 154128 | 804 | 64343781 |
Aspergillus infection | 26.03 | 9.78 | 4 | 154143 | 16375 | 64328210 |
Tachyphrenia | 25.96 | 9.78 | 27 | 154120 | 1849 | 64342736 |
Influenza like illness | 25.87 | 9.78 | 243 | 153904 | 61459 | 64283126 |
Neutrophil count decreased | 25.81 | 9.78 | 96 | 154051 | 77100 | 64267485 |
Asphyxia | 25.79 | 9.78 | 65 | 154082 | 9501 | 64335084 |
Antidepressant drug level increased | 25.55 | 9.78 | 14 | 154133 | 356 | 64344229 |
Respiratory failure | 25.49 | 9.78 | 254 | 153893 | 160929 | 64183656 |
Initial insomnia | 25.46 | 9.78 | 48 | 154099 | 5756 | 64338829 |
Yawning | 25.44 | 9.78 | 22 | 154125 | 1194 | 64343391 |
Antipsychotic drug level below therapeutic | 25.15 | 9.78 | 20 | 154127 | 965 | 64343620 |
Catatonia | 25.12 | 9.78 | 56 | 154091 | 7564 | 64337021 |
Injury | 24.73 | 9.78 | 223 | 153924 | 55769 | 64288816 |
Bacteraemia | 24.70 | 9.78 | 17 | 154130 | 26894 | 64317691 |
Rhabdomyolysis | 24.65 | 9.78 | 331 | 153816 | 91395 | 64253190 |
Liver disorder | 24.63 | 9.78 | 57 | 154090 | 53294 | 64291291 |
Thrombotic microangiopathy | 24.44 | 9.78 | 5 | 154142 | 16650 | 64327935 |
Somnambulism | 24.42 | 9.78 | 44 | 154103 | 5097 | 64339488 |
Ventricular hypokinesia | 24.39 | 9.78 | 56 | 154091 | 7713 | 64336872 |
Tumour lysis syndrome | 24.39 | 9.78 | 8 | 154139 | 19432 | 64325153 |
Coordination abnormal | 24.36 | 9.78 | 85 | 154062 | 14879 | 64329706 |
Burning mouth syndrome | 24.31 | 9.78 | 15 | 154132 | 479 | 64344106 |
Tachycardia | 24.31 | 9.78 | 497 | 153650 | 149082 | 64195503 |
Self esteem decreased | 24.23 | 9.78 | 19 | 154128 | 898 | 64343687 |
Posture abnormal | 24.19 | 9.78 | 35 | 154112 | 3371 | 64341214 |
Heart sounds | 23.96 | 9.78 | 16 | 154131 | 587 | 64343998 |
Heart rate | 23.81 | 9.78 | 8 | 154139 | 56 | 64344529 |
Respiration abnormal | 23.80 | 9.78 | 49 | 154098 | 6266 | 64338319 |
Ill-defined disorder | 23.79 | 9.78 | 43 | 154104 | 44009 | 64300576 |
Serum serotonin decreased | 23.67 | 9.78 | 6 | 154141 | 12 | 64344573 |
Sternal fracture | 23.61 | 9.78 | 28 | 154119 | 2219 | 64342366 |
Treatment noncompliance | 23.37 | 9.78 | 181 | 153966 | 43301 | 64301284 |
Decreased interest | 23.10 | 9.78 | 34 | 154113 | 3326 | 64341259 |
Anterograde amnesia | 23.09 | 9.78 | 16 | 154131 | 624 | 64343961 |
Disseminated intravascular coagulation | 22.99 | 9.78 | 26 | 154121 | 32322 | 64312263 |
Protein C increased | 22.98 | 9.78 | 9 | 154138 | 102 | 64344483 |
Dysarthria | 22.96 | 9.78 | 230 | 153917 | 59176 | 64285409 |
Priapism | 22.84 | 9.78 | 37 | 154110 | 3933 | 64340652 |
Haemophagocytic lymphohistiocytosis | 22.53 | 9.78 | 7 | 154140 | 17602 | 64326983 |
Compulsive shopping | 22.50 | 9.78 | 17 | 154130 | 760 | 64343825 |
Diet failure | 22.49 | 9.78 | 7 | 154140 | 37 | 64344548 |
Osteonecrosis of jaw | 22.30 | 9.78 | 38 | 154109 | 39787 | 64304798 |
Accidental overdose | 22.28 | 9.78 | 147 | 154000 | 33410 | 64311175 |
Drug screen positive | 22.24 | 9.78 | 45 | 154102 | 5684 | 64338901 |
Therapeutic response unexpected | 22.21 | 9.78 | 90 | 154057 | 16911 | 64327674 |
Choreoathetosis | 22.17 | 9.78 | 22 | 154125 | 1425 | 64343160 |
Pneumocystis jirovecii pneumonia | 22.16 | 9.78 | 20 | 154127 | 27614 | 64316971 |
Depressive symptom | 22.02 | 9.78 | 39 | 154108 | 4457 | 64340128 |
Bulimia nervosa | 21.98 | 9.78 | 11 | 154136 | 231 | 64344354 |
Myocardial infarction | 21.98 | 9.78 | 272 | 153875 | 165549 | 64179036 |
Personality disorder | 21.97 | 9.78 | 40 | 154107 | 4671 | 64339914 |
Polyneuropathy | 21.96 | 9.78 | 10 | 154137 | 19884 | 64324701 |
Trichotillomania | 21.84 | 9.78 | 10 | 154137 | 171 | 64344414 |
Autonomic nervous system imbalance | 21.75 | 9.78 | 37 | 154110 | 4095 | 64340490 |
Hyporesponsive to stimuli | 21.59 | 9.78 | 24 | 154123 | 1773 | 64342812 |
Disorientation | 21.50 | 9.78 | 216 | 153931 | 55612 | 64288973 |
Depression suicidal | 21.45 | 9.78 | 28 | 154119 | 2447 | 64342138 |
Hypertonia | 21.44 | 9.78 | 47 | 154100 | 6278 | 64338307 |
Oral discharge | 21.23 | 9.78 | 11 | 154136 | 249 | 64344336 |
Chorea | 21.14 | 9.78 | 25 | 154122 | 1975 | 64342610 |
Myelodysplastic syndrome | 20.90 | 9.78 | 21 | 154126 | 27558 | 64317027 |
Haematotoxicity | 20.83 | 9.78 | 3 | 154144 | 12893 | 64331692 |
Obsessive-compulsive symptom | 20.72 | 9.78 | 9 | 154138 | 135 | 64344450 |
Inflammation | 20.67 | 9.78 | 83 | 154064 | 65217 | 64279368 |
Sinusitis | 20.63 | 9.78 | 236 | 153911 | 145692 | 64198893 |
Musculoskeletal pain | 20.62 | 9.78 | 112 | 154035 | 81182 | 64263403 |
Graft versus host disease | 20.57 | 9.78 | 4 | 154143 | 13809 | 64330776 |
Panic disorder | 20.57 | 9.78 | 29 | 154118 | 2728 | 64341857 |
Sluggishness | 20.21 | 9.78 | 43 | 154104 | 5627 | 64338958 |
Red blood cell sedimentation rate increased | 20.20 | 9.78 | 27 | 154120 | 31208 | 64313377 |
Analgesic drug level increased | 20.17 | 9.78 | 26 | 154121 | 2244 | 64342341 |
Agitation neonatal | 20.16 | 9.78 | 4 | 154143 | 0 | 64344585 |
Cardiac failure congestive | 20.13 | 9.78 | 207 | 153940 | 130373 | 64214212 |
Mast cell activation syndrome | 20.09 | 9.78 | 12 | 154135 | 361 | 64344224 |
Pathogen resistance | 20.07 | 9.78 | 3 | 154144 | 12540 | 64332045 |
Alcohol interaction | 20.06 | 9.78 | 37 | 154110 | 4364 | 64340221 |
Dreamy state | 20.03 | 9.78 | 7 | 154140 | 56 | 64344529 |
Ventricular fibrillation | 19.97 | 9.78 | 111 | 154036 | 23749 | 64320836 |
Patent ductus arteriosus | 19.95 | 9.78 | 8 | 154139 | 97 | 64344488 |
Exposure during pregnancy | 19.93 | 9.78 | 278 | 153869 | 77397 | 64267188 |
Sleep-related eating disorder | 19.92 | 9.78 | 15 | 154132 | 667 | 64343918 |
Phobia | 19.77 | 9.78 | 12 | 154135 | 372 | 64344213 |
Ideas of reference | 19.76 | 9.78 | 9 | 154138 | 152 | 64344433 |
Blood urea increased | 19.72 | 9.78 | 48 | 154099 | 44105 | 64300480 |
Urinary incontinence | 19.72 | 9.78 | 151 | 153996 | 36000 | 64308585 |
Cerebral infarction | 19.64 | 9.78 | 43 | 154104 | 41001 | 64303584 |
Exposure via ingestion | 19.62 | 9.78 | 39 | 154108 | 4863 | 64339722 |
Thought insertion | 19.56 | 9.78 | 6 | 154141 | 30 | 64344555 |
Prolonged expiration | 19.51 | 9.78 | 16 | 154131 | 807 | 64343778 |
Stress | 19.51 | 9.78 | 226 | 153921 | 60308 | 64284277 |
Hallucinations, mixed | 19.42 | 9.78 | 44 | 154103 | 6008 | 64338577 |
Cataplexy | 19.37 | 9.78 | 16 | 154131 | 815 | 64343770 |
Economic problem | 19.36 | 9.78 | 25 | 154122 | 2162 | 64342423 |
Delusion of grandeur | 19.34 | 9.78 | 14 | 154133 | 586 | 64343999 |
Genital anaesthesia | 19.10 | 9.78 | 5 | 154142 | 12 | 64344573 |
IIIrd nerve paresis | 18.94 | 9.78 | 9 | 154138 | 168 | 64344417 |
Alcohol use | 18.89 | 9.78 | 37 | 154110 | 4565 | 64340020 |
Drug eruption | 18.87 | 9.78 | 36 | 154111 | 36100 | 64308485 |
Hospitalisation | 18.86 | 9.78 | 104 | 154043 | 75103 | 64269482 |
Accommodation disorder | 18.85 | 9.78 | 13 | 154134 | 503 | 64344082 |
Post-traumatic neck syndrome | 18.84 | 9.78 | 23 | 154124 | 1879 | 64342706 |
Pulmonary haemosiderosis | 18.82 | 9.78 | 5 | 154142 | 13 | 64344572 |
Renal failure | 18.81 | 9.78 | 313 | 153834 | 181375 | 64163210 |
CYP3A4 polymorphism | 18.65 | 9.78 | 7 | 154140 | 70 | 64344515 |
Epidural lipomatosis | 18.62 | 9.78 | 16 | 154131 | 861 | 64343724 |
Induced abortion failed | 18.29 | 9.78 | 9 | 154138 | 182 | 64344403 |
Agoraphobia | 18.17 | 9.78 | 13 | 154134 | 534 | 64344051 |
Serum sickness-like reaction | 18.11 | 9.78 | 13 | 154134 | 537 | 64344048 |
Interstitial lung disease | 18.07 | 9.78 | 148 | 153999 | 97584 | 64247001 |
Heart rate decreased | 18.07 | 9.78 | 69 | 154078 | 54998 | 64289587 |
Blood pressure diastolic decreased | 18.05 | 9.78 | 16 | 154131 | 22285 | 64322300 |
Respiratory disorder | 17.97 | 9.78 | 37 | 154110 | 36074 | 64308511 |
Posterior reversible encephalopathy syndrome | 17.93 | 9.78 | 17 | 154130 | 22929 | 64321656 |
Hypoplastic left heart syndrome | 17.92 | 9.78 | 4 | 154143 | 3 | 64344582 |
Peritonitis | 17.90 | 9.78 | 20 | 154127 | 25003 | 64319582 |
Hypoalbuminaemia | 17.84 | 9.78 | 10 | 154137 | 17664 | 64326921 |
Anaphylactic reaction | 17.74 | 9.78 | 94 | 154053 | 68570 | 64276015 |
Product use in unapproved indication | 17.72 | 9.78 | 306 | 153841 | 176312 | 64168273 |
Feeling drunk | 17.71 | 9.78 | 34 | 154113 | 4133 | 64340452 |
Colitis | 17.69 | 9.78 | 76 | 154071 | 58598 | 64285987 |
Feeling of despair | 17.68 | 9.78 | 26 | 154121 | 2542 | 64342043 |
Bronchopulmonary aspergillosis | 17.59 | 9.78 | 12 | 154135 | 19073 | 64325512 |
Asthenia | 17.55 | 9.78 | 840 | 153307 | 427204 | 63917381 |
Blood pressure systolic increased | 17.52 | 9.78 | 60 | 154087 | 49393 | 64295192 |
Prostate cancer | 17.52 | 9.78 | 13 | 154134 | 19782 | 64324803 |
Narcolepsy | 17.48 | 9.78 | 17 | 154130 | 1074 | 64343511 |
Metabolic acidosis | 17.42 | 9.78 | 252 | 153895 | 70706 | 64273879 |
Retinal phototoxicity | 17.39 | 9.78 | 4 | 154143 | 4 | 64344581 |
Neutropenic sepsis | 17.32 | 9.78 | 18 | 154129 | 23254 | 64321331 |
Psychomotor retardation | 17.18 | 9.78 | 38 | 154109 | 5105 | 64339480 |
Amenorrhoea | 17.18 | 9.78 | 44 | 154103 | 6495 | 64338090 |
Pupil fixed | 17.09 | 9.78 | 29 | 154118 | 3203 | 64341382 |
Serum ferritin abnormal | 17.03 | 9.78 | 11 | 154136 | 381 | 64344204 |
Vision blurred | 17.02 | 9.78 | 307 | 153840 | 90009 | 64254576 |
Chronic actinic dermatitis | 17.00 | 9.78 | 5 | 154142 | 21 | 64344564 |
Liver function test increased | 16.93 | 9.78 | 30 | 154117 | 30940 | 64313645 |
Pituitary tumour benign | 16.93 | 9.78 | 24 | 154123 | 2269 | 64342316 |
Neonatal seizure | 16.92 | 9.78 | 4 | 154143 | 5 | 64344580 |
Proteinuria | 16.90 | 9.78 | 25 | 154122 | 27698 | 64316887 |
Gallbladder disorder | 16.85 | 9.78 | 83 | 154064 | 16947 | 64327638 |
Tubulointerstitial nephritis | 16.84 | 9.78 | 30 | 154117 | 30879 | 64313706 |
Enterocolitis | 16.84 | 9.78 | 4 | 154143 | 12014 | 64332571 |
Pseudomonas infection | 16.81 | 9.78 | 11 | 154136 | 17872 | 64326713 |
Cytokine release syndrome | 16.79 | 9.78 | 15 | 154132 | 20814 | 64323771 |
Cellulitis | 16.78 | 9.78 | 143 | 154004 | 93514 | 64251071 |
Complication of device insertion | 16.71 | 9.78 | 37 | 154110 | 4975 | 64339610 |
Foetal arrhythmia | 16.64 | 9.78 | 5 | 154142 | 23 | 64344562 |
Device placement issue | 16.64 | 9.78 | 14 | 154133 | 732 | 64343853 |
Acute myeloid leukaemia | 16.51 | 9.78 | 25 | 154122 | 27438 | 64317147 |
Tenosynovitis | 16.46 | 9.78 | 4 | 154143 | 11829 | 64332756 |
Sexual dysfunction | 16.44 | 9.78 | 43 | 154104 | 6428 | 64338157 |
Supraventricular tachyarrhythmia | 16.30 | 9.78 | 7 | 154140 | 102 | 64344483 |
Dehydroepiandrosterone decreased | 16.30 | 9.78 | 5 | 154142 | 25 | 64344560 |
Micturition urgency | 16.14 | 9.78 | 58 | 154089 | 10301 | 64334284 |
Tinnitus | 16.14 | 9.78 | 138 | 154009 | 33995 | 64310590 |
Oedema peripheral | 16.12 | 9.78 | 381 | 153766 | 209936 | 64134649 |
Feeling jittery | 16.11 | 9.78 | 59 | 154088 | 10576 | 64334009 |
Antisocial personality disorder | 15.98 | 9.78 | 5 | 154142 | 27 | 64344558 |
Agranulocytosis | 15.97 | 9.78 | 43 | 154104 | 38186 | 64306399 |
Oesophageal food impaction | 15.86 | 9.78 | 10 | 154137 | 332 | 64344253 |
Disturbance in sexual arousal | 15.86 | 9.78 | 8 | 154139 | 171 | 64344414 |
Productive cough | 15.85 | 9.78 | 106 | 154041 | 73097 | 64271488 |
Hypercalcaemia | 15.80 | 9.78 | 32 | 154115 | 31384 | 64313201 |
Gambling disorder | 15.75 | 9.78 | 21 | 154126 | 1873 | 64342712 |
Oedema | 15.75 | 9.78 | 142 | 154005 | 91793 | 64252792 |
Hypnopompic hallucination | 15.73 | 9.78 | 6 | 154141 | 63 | 64344522 |
COVID-19 pneumonia | 15.72 | 9.78 | 10 | 154137 | 16494 | 64328091 |
Sleep paralysis | 15.70 | 9.78 | 12 | 154135 | 546 | 64344039 |
Binge eating | 15.65 | 9.78 | 11 | 154136 | 439 | 64344146 |
Slow response to stimuli | 15.62 | 9.78 | 19 | 154128 | 1546 | 64343039 |
Antisocial behaviour | 15.60 | 9.78 | 12 | 154135 | 551 | 64344034 |
Jaundice neonatal | 15.49 | 9.78 | 7 | 154140 | 116 | 64344469 |
Formication | 15.48 | 9.78 | 33 | 154114 | 4324 | 64340261 |
Secondary hypogonadism | 15.44 | 9.78 | 10 | 154137 | 348 | 64344237 |
Road traffic accident | 15.44 | 9.78 | 126 | 154021 | 30619 | 64313966 |
Self-medication | 15.43 | 9.78 | 32 | 154115 | 4113 | 64340472 |
Loss of consciousness | 15.41 | 9.78 | 464 | 153683 | 147901 | 64196684 |
Cytopenia | 15.26 | 9.78 | 9 | 154138 | 15462 | 64329123 |
Musculoskeletal stiffness | 15.25 | 9.78 | 205 | 153942 | 123001 | 64221584 |
Drooling | 15.24 | 9.78 | 37 | 154110 | 5282 | 64339303 |
Transaminases increased | 15.20 | 9.78 | 55 | 154092 | 44539 | 64300046 |
Cholecystectomy | 15.19 | 9.78 | 48 | 154099 | 7984 | 64336601 |
Fluid retention | 15.18 | 9.78 | 82 | 154065 | 59524 | 64285061 |
Anhedonia | 15.17 | 9.78 | 69 | 154078 | 13637 | 64330948 |
Spinal shock | 15.13 | 9.78 | 5 | 154142 | 33 | 64344552 |
Chronic kidney disease | 15.13 | 9.78 | 79 | 154068 | 57840 | 64286745 |
Tremor neonatal | 15.12 | 9.78 | 3 | 154144 | 0 | 64344585 |
Parkinsonian gait | 15.07 | 9.78 | 14 | 154133 | 835 | 64343750 |
Diverticulitis | 14.98 | 9.78 | 45 | 154102 | 38573 | 64306012 |
Selective mutism | 14.94 | 9.78 | 6 | 154141 | 73 | 64344512 |
Energy increased | 14.92 | 9.78 | 25 | 154122 | 2733 | 64341852 |
Sudden onset of sleep | 14.88 | 9.78 | 12 | 154135 | 591 | 64343994 |
Therapeutic product effect variable | 14.88 | 9.78 | 19 | 154128 | 1625 | 64342960 |
Dermatillomania | 14.87 | 9.78 | 8 | 154139 | 196 | 64344389 |
Fatigue | 14.87 | 9.78 | 1565 | 152582 | 747165 | 63597420 |
Attention deficit hyperactivity disorder | 14.84 | 9.78 | 25 | 154122 | 2745 | 64341840 |
Atrial septal defect | 14.79 | 9.78 | 19 | 154128 | 1634 | 64342951 |
Rash maculo-papular | 14.74 | 9.78 | 60 | 154087 | 46966 | 64297619 |
Hyperdynamic left ventricle | 14.74 | 9.78 | 9 | 154138 | 282 | 64344303 |
Concussion | 14.61 | 9.78 | 47 | 154100 | 7891 | 64336694 |
Death of relative | 14.55 | 9.78 | 8 | 154139 | 205 | 64344380 |
Mental status changes | 14.53 | 9.78 | 216 | 153931 | 60946 | 64283639 |
Blood pressure measurement | 14.52 | 9.78 | 10 | 154137 | 386 | 64344199 |
Atrioventricular block second degree | 14.51 | 9.78 | 41 | 154106 | 6413 | 64338172 |
Tourette's disorder | 14.45 | 9.78 | 6 | 154141 | 80 | 64344505 |
Large intestine perforation | 14.44 | 9.78 | 6 | 154141 | 12598 | 64331987 |
Cytomegalovirus viraemia | 14.41 | 9.78 | 4 | 154143 | 10824 | 64333761 |
Cholangitis | 14.36 | 9.78 | 4 | 154143 | 10798 | 64333787 |
Gastric bypass | 14.33 | 9.78 | 15 | 154132 | 1035 | 64343550 |
Locked-in syndrome | 14.32 | 9.78 | 12 | 154135 | 624 | 64343961 |
Breath sounds abnormal | 14.30 | 9.78 | 5 | 154142 | 11664 | 64332921 |
Hip arthroplasty | 14.28 | 9.78 | 18 | 154129 | 21333 | 64323252 |
COVID-19 | 14.27 | 9.78 | 94 | 154053 | 65046 | 64279539 |
Pregnancy on oral contraceptive | 14.24 | 9.78 | 13 | 154134 | 758 | 64343827 |
Hypoprolactinaemia | 14.17 | 9.78 | 4 | 154143 | 14 | 64344571 |
Salivary hypersecretion | 14.17 | 9.78 | 62 | 154085 | 12051 | 64332534 |
Klebsiella infection | 14.16 | 9.78 | 7 | 154140 | 13274 | 64331311 |
Haemorrhage intracranial | 14.11 | 9.78 | 22 | 154125 | 23862 | 64320723 |
Constipation | 14.04 | 9.78 | 429 | 153718 | 228908 | 64115677 |
Accidental exposure to product | 14.00 | 9.78 | 26 | 154121 | 26338 | 64318247 |
Coma uraemic | 13.99 | 9.78 | 5 | 154142 | 43 | 64344542 |
Thrombosis | 13.98 | 9.78 | 105 | 154042 | 70537 | 64274048 |
Jaw clicking | 13.96 | 9.78 | 4 | 154143 | 15 | 64344570 |
Eating disorder | 13.94 | 9.78 | 78 | 154069 | 16727 | 64327858 |
Post 5-alpha-reductase inhibitor syndrome | 13.87 | 9.78 | 6 | 154141 | 89 | 64344496 |
Tongue biting | 13.86 | 9.78 | 19 | 154128 | 1741 | 64342844 |
Autism spectrum disorder | 13.85 | 9.78 | 14 | 154133 | 927 | 64343658 |
Skin ulcer | 13.85 | 9.78 | 56 | 154091 | 43918 | 64300667 |
Pruritus | 13.81 | 9.78 | 608 | 153539 | 311792 | 64032793 |
Decreased appetite | 13.80 | 9.78 | 541 | 153606 | 280748 | 64063837 |
Pneumothorax | 13.77 | 9.78 | 23 | 154124 | 24275 | 64320310 |
Epistaxis | 13.75 | 9.78 | 159 | 153988 | 97972 | 64246613 |
Pericardial effusion | 13.66 | 9.78 | 48 | 154099 | 39206 | 64305379 |
Antidepressant drug level above therapeutic | 13.65 | 9.78 | 11 | 154136 | 541 | 64344044 |
Breast discomfort | 13.63 | 9.78 | 9 | 154138 | 324 | 64344261 |
Logorrhoea | 13.57 | 9.78 | 30 | 154117 | 4029 | 64340556 |
Metastases to lung | 13.54 | 9.78 | 10 | 154137 | 15254 | 64329331 |
Blood test abnormal | 13.53 | 9.78 | 7 | 154140 | 12936 | 64331649 |
Alcohol withdrawal syndrome | 13.50 | 9.78 | 19 | 154128 | 1784 | 64342801 |
Diffuse large B-cell lymphoma | 13.47 | 9.78 | 4 | 154143 | 10357 | 64334228 |
Bradycardia | 13.45 | 9.78 | 374 | 153773 | 117845 | 64226740 |
Cold agglutinins positive | 13.41 | 9.78 | 5 | 154142 | 49 | 64344536 |
Prolonged rupture of membranes | 13.33 | 9.78 | 5 | 154142 | 50 | 64344535 |
Personality change | 13.29 | 9.78 | 48 | 154099 | 8545 | 64336040 |
Electrolyte depletion | 13.24 | 9.78 | 9 | 154138 | 340 | 64344245 |
Chemical burn | 13.24 | 9.78 | 10 | 154137 | 447 | 64344138 |
Confabulation | 13.20 | 9.78 | 10 | 154137 | 449 | 64344136 |
Renal disorder | 13.15 | 9.78 | 42 | 154105 | 35323 | 64309262 |
Mutism | 13.15 | 9.78 | 20 | 154127 | 2014 | 64342571 |
Device related infection | 13.13 | 9.78 | 34 | 154113 | 30592 | 64313993 |
Haemolysis | 13.07 | 9.78 | 5 | 154142 | 11034 | 64333551 |
Gestational diabetes | 13.05 | 9.78 | 36 | 154111 | 5554 | 64339031 |
Faecal calprotectin | 13.04 | 9.78 | 4 | 154143 | 20 | 64344565 |
Umbilical cord around neck | 13.04 | 9.78 | 4 | 154143 | 20 | 64344565 |
Urinary retention | 12.99 | 9.78 | 177 | 153970 | 49024 | 64295561 |
Joint hyperextension | 12.90 | 9.78 | 8 | 154139 | 258 | 64344327 |
Prescribed overdose | 12.86 | 9.78 | 88 | 154059 | 20243 | 64324342 |
Ventricular arrhythmia | 12.84 | 9.78 | 43 | 154104 | 7372 | 64337213 |
Purple glove syndrome | 12.79 | 9.78 | 8 | 154139 | 262 | 64344323 |
Venoocclusive liver disease | 12.78 | 9.78 | 4 | 154143 | 10011 | 64334574 |
Blood creatine phosphokinase MB | 12.72 | 9.78 | 4 | 154143 | 22 | 64344563 |
Balance disorder | 12.70 | 9.78 | 276 | 153871 | 83650 | 64260935 |
Therapy change | 12.68 | 9.78 | 39 | 154108 | 6395 | 64338190 |
Nystagmus | 12.65 | 9.78 | 49 | 154098 | 9019 | 64335566 |
Basal cell carcinoma | 12.64 | 9.78 | 35 | 154112 | 30803 | 64313782 |
Candida infection | 12.63 | 9.78 | 36 | 154111 | 31383 | 64313202 |
Vascular stenosis | 12.62 | 9.78 | 10 | 154137 | 480 | 64344105 |
Dissociative identity disorder | 12.59 | 9.78 | 5 | 154142 | 59 | 64344526 |
Dyspnoea exertional | 12.58 | 9.78 | 114 | 154033 | 73616 | 64270969 |
Appetite disorder | 12.58 | 9.78 | 39 | 154108 | 6422 | 64338163 |
Haemorrhage | 12.55 | 9.78 | 125 | 154022 | 79226 | 64265359 |
Body temperature decreased | 12.54 | 9.78 | 27 | 154120 | 25901 | 64318684 |
Hypervolaemia | 12.54 | 9.78 | 48 | 154099 | 38237 | 64306348 |
Blood magnesium decreased | 12.52 | 9.78 | 66 | 154081 | 13839 | 64330746 |
Muscle necrosis | 12.46 | 9.78 | 15 | 154132 | 1208 | 64343377 |
Second primary malignancy | 12.42 | 9.78 | 7 | 154140 | 12330 | 64332255 |
Enterococcal infection | 12.41 | 9.78 | 9 | 154138 | 13857 | 64330728 |
Multiple system atrophy | 12.40 | 9.78 | 9 | 154138 | 378 | 64344207 |
Lumbar radiculopathy | 12.40 | 9.78 | 18 | 154129 | 1739 | 64342846 |
Ventricular hypertrophy | 12.38 | 9.78 | 39 | 154108 | 6477 | 64338108 |
Back pain | 12.30 | 9.78 | 481 | 153666 | 249690 | 64094895 |
Impulse-control disorder | 12.29 | 9.78 | 17 | 154130 | 1571 | 64343014 |
Vasoplegia syndrome | 12.28 | 9.78 | 23 | 154124 | 2744 | 64341841 |
Brugada syndrome | 12.27 | 9.78 | 14 | 154133 | 1064 | 64343521 |
Resting tremor | 12.26 | 9.78 | 16 | 154131 | 1398 | 64343187 |
Procedural hypertension | 12.24 | 9.78 | 8 | 154139 | 283 | 64344302 |
Dehydration | 12.18 | 9.78 | 410 | 153737 | 216353 | 64128232 |
Blood triglycerides increased | 12.14 | 9.78 | 82 | 154065 | 18784 | 64325801 |
Toxic skin eruption | 12.14 | 9.78 | 17 | 154130 | 19267 | 64325318 |
Prostatic specific antigen increased | 12.11 | 9.78 | 3 | 154144 | 8757 | 64335828 |
Red blood cell count decreased | 12.08 | 9.78 | 67 | 154080 | 48319 | 64296266 |
Affect lability | 12.07 | 9.78 | 48 | 154099 | 8942 | 64335643 |
Haematochezia | 12.04 | 9.78 | 101 | 154046 | 66272 | 64278313 |
Enthesopathy | 12.03 | 9.78 | 4 | 154143 | 9634 | 64334951 |
Plasma cell mastitis | 12.03 | 9.78 | 4 | 154143 | 27 | 64344558 |
Blood pressure increased | 12.03 | 9.78 | 317 | 153830 | 172235 | 64172350 |
Persecutory delusion | 12.00 | 9.78 | 29 | 154118 | 4129 | 64340456 |
End stage renal disease | 11.98 | 9.78 | 5 | 154142 | 10470 | 64334115 |
Coagulation factor VII level decreased | 11.98 | 9.78 | 7 | 154140 | 202 | 64344383 |
Appendicitis perforated | 11.97 | 9.78 | 23 | 154124 | 2797 | 64341788 |
Hypoxic-ischaemic encephalopathy | 11.97 | 9.78 | 41 | 154106 | 7111 | 64337474 |
Compulsive hoarding | 11.95 | 9.78 | 5 | 154142 | 68 | 64344517 |
Skin infection | 11.92 | 9.78 | 11 | 154136 | 15026 | 64329559 |
Metastases to bone | 11.90 | 9.78 | 19 | 154128 | 20416 | 64324169 |
Agonal rhythm | 11.89 | 9.78 | 5 | 154142 | 69 | 64344516 |
Acquired cardiac septal defect | 11.84 | 9.78 | 3 | 154144 | 6 | 64344579 |
Apgar score low | 11.84 | 9.78 | 3 | 154144 | 6 | 64344579 |
Right aortic arch | 11.84 | 9.78 | 3 | 154144 | 6 | 64344579 |
Loss of bladder sensation | 11.82 | 9.78 | 5 | 154142 | 70 | 64344515 |
Vaginal haemorrhage | 11.81 | 9.78 | 83 | 154064 | 19261 | 64325324 |
Food interaction | 11.81 | 9.78 | 16 | 154131 | 1450 | 64343135 |
Blood potassium decreased | 11.78 | 9.78 | 148 | 153999 | 40251 | 64304334 |
Skin cancer | 11.76 | 9.78 | 7 | 154140 | 11967 | 64332618 |
Dissociative disorder | 11.73 | 9.78 | 9 | 154138 | 412 | 64344173 |
Cataract | 11.72 | 9.78 | 73 | 154074 | 51189 | 64293396 |
Hypogammaglobulinaemia | 11.65 | 9.78 | 5 | 154142 | 10294 | 64334291 |
Osteonecrosis | 11.60 | 9.78 | 32 | 154115 | 28197 | 64316388 |
Knee arthroplasty | 11.55 | 9.78 | 30 | 154117 | 26969 | 64317616 |
Duodenal ulcer repair | 11.51 | 9.78 | 5 | 154142 | 75 | 64344510 |
Drug resistance | 11.50 | 9.78 | 44 | 154103 | 35058 | 64309527 |
Dizziness | 11.49 | 9.78 | 1185 | 152962 | 428978 | 63915607 |
Intervertebral disc displacement | 11.48 | 9.78 | 9 | 154138 | 425 | 64344160 |
Gout | 11.47 | 9.78 | 21 | 154126 | 21392 | 64323193 |
Stereotypy | 11.44 | 9.78 | 12 | 154135 | 830 | 64343755 |
Cholinergic syndrome | 11.43 | 9.78 | 12 | 154135 | 831 | 64343754 |
Plasma cell myeloma | 11.39 | 9.78 | 64 | 154083 | 46011 | 64298574 |
Pain in extremity | 11.39 | 9.78 | 600 | 153547 | 302485 | 64042100 |
Grandiosity | 11.37 | 9.78 | 10 | 154137 | 555 | 64344030 |
Full blood count decreased | 11.36 | 9.78 | 23 | 154124 | 22559 | 64322026 |
Drug-induced liver injury | 11.34 | 9.78 | 67 | 154080 | 47576 | 64297009 |
Placenta praevia | 11.31 | 9.78 | 11 | 154136 | 695 | 64343890 |
Metastases to central nervous system | 11.24 | 9.78 | 10 | 154137 | 13902 | 64330683 |
Hypnagogic hallucination | 11.23 | 9.78 | 6 | 154141 | 145 | 64344440 |
Neonatal respiratory distress syndrome | 11.17 | 9.78 | 7 | 154140 | 230 | 64344355 |
Renal artery thrombosis | 11.14 | 9.78 | 9 | 154138 | 444 | 64344141 |
Chronic fatigue syndrome | 11.11 | 9.78 | 14 | 154133 | 1181 | 64343404 |
Psychotic behaviour | 11.11 | 9.78 | 13 | 154134 | 1016 | 64343569 |
Gaze palsy | 11.08 | 9.78 | 21 | 154126 | 2529 | 64342056 |
Pulmonary vasculitis | 11.06 | 9.78 | 7 | 154140 | 234 | 64344351 |
Compulsions | 10.98 | 9.78 | 8 | 154139 | 338 | 64344247 |
Medical diet | 10.98 | 9.78 | 3 | 154144 | 9 | 64344576 |
Cerebrovascular stenosis | 10.97 | 9.78 | 6 | 154141 | 152 | 64344433 |
Pulmonary valve stenosis | 10.94 | 9.78 | 4 | 154143 | 37 | 64344548 |
Creatinine renal clearance decreased | 10.90 | 9.78 | 11 | 154136 | 14410 | 64330175 |
Hyperthermia | 10.86 | 9.78 | 69 | 154078 | 15481 | 64329104 |
Hypothermia | 10.86 | 9.78 | 83 | 154064 | 19773 | 64324812 |
Exposure via inhalation | 10.84 | 9.78 | 5 | 154142 | 87 | 64344498 |
Status migrainosus | 10.84 | 9.78 | 4 | 154143 | 38 | 64344547 |
Blood pressure decreased | 10.82 | 9.78 | 143 | 154004 | 86056 | 64258529 |
Withdrawal catatonia | 10.80 | 9.78 | 6 | 154141 | 157 | 64344428 |
Schizophrenia | 10.75 | 9.78 | 54 | 154093 | 11114 | 64333471 |
Hyperinsulinism | 10.74 | 9.78 | 3 | 154144 | 10 | 64344575 |
Premature baby | 10.73 | 9.78 | 24 | 154123 | 3248 | 64341337 |
Loss of personal independence in daily activities | 10.70 | 9.78 | 116 | 154031 | 72338 | 64272247 |
Peripheral sensory neuropathy | 10.70 | 9.78 | 7 | 154140 | 11371 | 64333214 |
Alpha 1 globulin increased | 10.69 | 9.78 | 5 | 154142 | 90 | 64344495 |
Acute psychosis | 10.65 | 9.78 | 26 | 154121 | 3726 | 64340859 |
Hepatic failure | 10.64 | 9.78 | 83 | 154064 | 55311 | 64289274 |
Maternal drugs affecting foetus | 10.58 | 9.78 | 16 | 154131 | 1604 | 64342981 |
Intrusive thoughts | 10.56 | 9.78 | 8 | 154139 | 359 | 64344226 |
Oral candidiasis | 10.55 | 9.78 | 25 | 154122 | 23187 | 64321398 |
Panniculitis | 10.55 | 9.78 | 4 | 154143 | 8875 | 64335710 |
Haematuria | 10.53 | 9.78 | 93 | 154054 | 60378 | 64284207 |
Head deformity | 10.49 | 9.78 | 4 | 154143 | 42 | 64344543 |
Febrile bone marrow aplasia | 10.48 | 9.78 | 7 | 154140 | 11248 | 64333337 |
Transient aphasia | 10.46 | 9.78 | 6 | 154141 | 167 | 64344418 |
Blood cholesterol increased | 10.45 | 9.78 | 173 | 153974 | 49893 | 64294692 |
Legal problem | 10.43 | 9.78 | 6 | 154141 | 168 | 64344417 |
Localised infection | 10.41 | 9.78 | 37 | 154110 | 30124 | 64314461 |
Eye colour change | 10.39 | 9.78 | 8 | 154139 | 368 | 64344217 |
Hypertriglyceridaemia | 10.39 | 9.78 | 7 | 154140 | 11198 | 64333387 |
Gastrointestinal hypermotility | 10.38 | 9.78 | 7 | 154140 | 261 | 64344324 |
Lymphocyte count decreased | 10.36 | 9.78 | 56 | 154091 | 40643 | 64303942 |
Lymphatic system neoplasm | 10.32 | 9.78 | 4 | 154143 | 44 | 64344541 |
Melanocytic hyperplasia | 10.32 | 9.78 | 3 | 154144 | 12 | 64344573 |
Cardiomegaly | 10.29 | 9.78 | 94 | 154053 | 23590 | 64320995 |
Spasmodic dysphonia | 10.27 | 9.78 | 6 | 154141 | 173 | 64344412 |
Food allergy | 10.26 | 9.78 | 3 | 154144 | 7848 | 64336737 |
Squamous cell carcinoma of skin | 10.25 | 9.78 | 8 | 154139 | 11868 | 64332717 |
Ventricular tachycardia | 10.19 | 9.78 | 126 | 154021 | 34139 | 64310446 |
Anorexia nervosa | 10.15 | 9.78 | 6 | 154141 | 177 | 64344408 |
Sleep attacks | 10.12 | 9.78 | 6 | 154141 | 178 | 64344407 |
Osteoporosis | 10.11 | 9.78 | 59 | 154088 | 42021 | 64302564 |
Toxic epidermal necrolysis | 10.10 | 9.78 | 50 | 154097 | 37116 | 64307469 |
Aplastic anaemia | 10.10 | 9.78 | 11 | 154136 | 13909 | 64330676 |
Brucellosis | 9.99 | 9.78 | 5 | 154142 | 105 | 64344480 |
Heavy menstrual bleeding | 9.98 | 9.78 | 56 | 154091 | 12021 | 64332564 |
Gastric disorder | 9.96 | 9.78 | 36 | 154111 | 29161 | 64315424 |
Regurgitation | 9.95 | 9.78 | 18 | 154129 | 2091 | 64342494 |
Full blood count abnormal | 9.95 | 9.78 | 37 | 154110 | 29720 | 64314865 |
Bradypnoea | 9.91 | 9.78 | 31 | 154116 | 5128 | 64339457 |
Internal haemorrhage | 9.90 | 9.78 | 3 | 154144 | 7664 | 64336921 |
Right ventricular failure | 9.86 | 9.78 | 23 | 154124 | 21448 | 64323137 |
Blood glucose fluctuation | 9.84 | 9.78 | 34 | 154113 | 5921 | 64338664 |
Breast enlargement | 9.84 | 9.78 | 14 | 154133 | 1328 | 64343257 |
Imprisonment | 9.80 | 9.78 | 9 | 154138 | 529 | 64344056 |
Strabismus | 9.78 | 9.78 | 18 | 154129 | 2119 | 64342466 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Feeling jittery | 44.99 | 21.75 | 18 | 757 | 44 | 83859 |
Exposure during pregnancy | 31.08 | 21.75 | 48 | 727 | 1275 | 82628 |
Hypertonia neonatal | 27.16 | 21.75 | 23 | 752 | 304 | 83599 |
Tremor neonatal | 23.52 | 21.75 | 13 | 762 | 79 | 83824 |
Source | Code | Description |
---|---|---|
ATC | N06AB03 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Selective serotonin reuptake inhibitors |
ATC | N06CA03 | NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOLEPTICS AND PSYCHOANALEPTICS IN COMBINATION Antidepressants in combination with psycholeptics |
FDA MoA | N0000000109 | Serotonin Uptake Inhibitors |
CHEBI has role | CHEBI:35469 | antidepressants |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:50949 | SSRI |
CHEBI has role | CHEBI:78298 | environmental contaminants |
CHEBI has role | CHEBI:88188 | allergenic drug |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D018687 | Antidepressive Agents, Second-Generation |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D065690 | Cytochrome P-450 CYP2D6 Inhibitors |
MeSH PA | D065607 | Cytochrome P-450 Enzyme Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D065606 | Metabolic Side Effects of Drugs and Substances |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D018490 | Serotonin Agents |
MeSH PA | D017367 | Serotonin Uptake Inhibitors |
FDA EPC | N0000175696 | Serotonin Reuptake Inhibitor |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Premenstrual dysphoric disorder | indication | 596004 | |
Depressive disorder | indication | 35489007 | |
Bulimia nervosa | indication | 78004001 | |
Bipolar affective disorder, current episode depression | indication | 191627008 | DOID:3312 |
Obsessive-compulsive disorder | indication | 191736004 | DOID:10933 |
Major depressive disorder | indication | 370143000 | |
Panic disorder | indication | 371631005 | DOID:594 |
Posttraumatic stress disorder | off-label use | 47505003 | DOID:2055 |
Postpartum depression | off-label use | 58703003 | DOID:9478 |
Cataplexy and narcolepsy | off-label use | 193042000 | |
Menopausal flushing | off-label use | 198436008 | |
Fibromyalgia | off-label use | 203082005 | DOID:631 |
Seasonal affective disorder | off-label use | 247803002 | |
Suicidal thoughts | contraindication | 6471006 | |
Weight gain finding | contraindication | 8943002 | |
Sinus tachycardia | contraindication | 11092001 | |
Hypercholesterolemia | contraindication | 13644009 | |
Bipolar disorder | contraindication | 13746004 | DOID:3312 |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Senile dementia | contraindication | 15662003 | |
Agranulocytosis | contraindication | 17182001 | DOID:12987 |
Lowered convulsive threshold | contraindication | 19260006 | |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Hypovolemia | contraindication | 28560003 | |
Orthostatic hypotension | contraindication | 28651003 | |
Dehydration | contraindication | 34095006 | |
Upper gastrointestinal hemorrhage | contraindication | 37372002 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Bradycardia | contraindication | 48867003 | |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Paralytic ileus | contraindication | 55525008 | DOID:8442 |
Hyperlipidemia | contraindication | 55822004 | DOID:1168 |
Anorexia nervosa | contraindication | 56882008 | DOID:8689 |
Abnormal sexual function | contraindication | 56925008 | |
Hepatic failure | contraindication | 59927004 | |
Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Heart failure | contraindication | 84114007 | DOID:6000 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Leukopenia | contraindication | 84828003 | DOID:615 |
Hyponatremia | contraindication | 89627008 | |
Tardive dyskinesia | contraindication | 102449007 | |
Seizure disorder | contraindication | 128613002 | |
Liver function tests abnormal | contraindication | 166603001 | |
Cerebrovascular accident | contraindication | 230690007 | |
Mania | contraindication | 231494001 | |
Hypomania | contraindication | 231496004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Metabolic syndrome X | contraindication | 237602007 | DOID:14221 |
Hyperprolactinemia | contraindication | 237662005 | DOID:12700 |
Transient ischemic attack | contraindication | 266257000 | DOID:224 |
Esophageal dysmotility | contraindication | 266434009 | DOID:9192 |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Hypertriglyceridemia | contraindication | 302870006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Serotonin syndrome | contraindication | 371089000 | |
At risk for aspiration | contraindication | 371736008 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Obesity | contraindication | 414916001 | DOID:9970 |
Carcinoma of female breast | contraindication | 447782002 | |
Smokes tobacco daily | contraindication | 449868002 |
Species | Use | Relation |
---|---|---|
Dogs | Separation anxiety | Indication |
Product | Applicant | Ingredients |
---|---|---|
Reconcile | Pegasus Laboratories Inc. | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.32 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Kd | 9.09 | WOMBAT-PK | CHEMBL | |||
Alpha-2A adrenergic receptor | GPCR | Ki | 8.20 | CHEMBL | |||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | IC50 | 6.07 | CHEMBL | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 6.16 | WOMBAT-PK | |||||
Sodium-dependent noradrenaline transporter | Transporter | Kd | 6.62 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 6.61 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2B | GPCR | ANTAGONIST | Ki | 5.30 | IUPHAR | ||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 6.40 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 6 | GPCR | Ki | 6.11 | CHEMBL | |||||
Alpha-1A adrenergic receptor | GPCR | Ki | 5.70 | PDSP | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 6.16 | DRUG MATRIX | |||||
D(3) dopamine receptor | GPCR | Ki | 5.70 | WOMBAT-PK | |||||
Histamine H1 receptor | GPCR | Ki | 5.96 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 6.05 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M2 | GPCR | Ki | 5.57 | PDSP | |||||
Muscarinic acetylcholine receptor M3 | GPCR | Ki | 6 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M4 | GPCR | Ki | 5.54 | PDSP | |||||
Muscarinic acetylcholine receptor M5 | GPCR | Ki | 5.57 | PDSP | |||||
Sodium-dependent dopamine transporter | Transporter | Kd | 5.44 | WOMBAT-PK | |||||
Cytochrome P450 2D6 | Enzyme | IC50 | 6.16 | DRUG MATRIX | |||||
Acetylcholinesterase | Enzyme | IC50 | 6.89 | CHEMBL | |||||
Potassium channel subfamily K member 2 | Ion channel | IC50 | 4.85 | CHEMBL | |||||
Histamine H3 receptor | GPCR | Ki | 5.14 | CHEMBL | |||||
Equilibrative nucleoside transporter 4 | Transporter | INHIBITOR | Ki | 4.64 | IUPHAR | ||||
Beta-1 adrenergic receptor | GPCR | Ki | 5.36 | WOMBAT-PK | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 8.70 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 6.11 | CHEMBL | |||||
5-hydroxytryptamine receptor 2A | GPCR | ANTAGONIST | Ki | 6.50 | IUPHAR | ||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.62 | CHEMBL | |||||
Transporter | Transporter | Ki | 6.84 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 7.97 | CHEMBL | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 7.07 | CHEMBL | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 6.96 | CHEMBL | |||||
5-hydroxytryptamine receptor 6 | GPCR | ANTAGONIST | Ki | 5.80 | IUPHAR | ||||
Transporter | Transporter | Ki | 6.80 | CHEMBL | |||||
Serotonin 1 (5-HT1) receptor | GPCR | IC50 | 7.82 | CHEMBL | |||||
Adrenergic receptor alpha-2 | GPCR | Ki | 5.72 | CHEMBL | |||||
Adrenergic receptor alpha-1 | GPCR | Ki | 6.22 | CHEMBL | |||||
Potassium voltage-gated channel subfamily C member 1 | Ion channel | IC50 | 4.88 | CHEMBL | |||||
G protein-activated inward rectifier potassium channel 2 | Ion channel | GATING INHIBITOR | IC50 | 4.80 | IUPHAR | ||||
Sigma intracellular receptor 2 | Unclassified | Ki | 4.79 | CHEMBL |
ID | Source |
---|---|
D00326 | KEGG_DRUG |
56296-78-7 | SECONDARY_CAS_RN |
4019389 | VANDF |
4019761 | VANDF |
C0016365 | UMLSCUI |
CHEBI:5118 | CHEBI |
RFX | PDB_CHEM_ID |
CHEMBL1201082 | ChEMBL_ID |
CHEMBL153036 | ChEMBL_ID |
CHEMBL41 | ChEMBL_ID |
DB00472 | DRUGBANK_ID |
D005473 | MESH_DESCRIPTOR_UI |
3386 | PUBCHEM_CID |
203 | IUPHAR_LIGAND_ID |
3883 | INN_ID |
01K63SUP8D | UNII |
227224 | RXNORM |
17711 | MMSL |
37675 | MMSL |
4091 | MMSL |
41730 | MMSL |
4746 | MMSL |
d00236 | MMSL |
001514 | NDDF |
004613 | NDDF |
372767007 | SNOMEDCT_US |
53640004 | SNOMEDCT_US |
75115009 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Symbyax | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0002-3230 | CAPSULE | 25 mg | ORAL | NDA | 34 sections |
Symbyax | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0002-3231 | CAPSULE | 25 mg | ORAL | NDA | 34 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0807 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 32 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0807 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 32 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5262 | TABLET, FILM COATED | 60 mg | ORAL | ANDA | 32 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5262 | TABLET, FILM COATED | 60 mg | ORAL | ANDA | 32 sections |
Olanzapine and Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-5503 | CAPSULE | 25 mg | ORAL | ANDA | 32 sections |
Olanzapine and Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-5504 | CAPSULE | 25 mg | ORAL | ANDA | 32 sections |
Olanzapine and Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-5505 | CAPSULE | 50 mg | ORAL | ANDA | 32 sections |
Olanzapine and Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-5506 | CAPSULE | 25 mg | ORAL | ANDA | 32 sections |
Olanzapine and Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-5507 | CAPSULE | 50 mg | ORAL | ANDA | 32 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7188 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 32 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7188 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 32 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7198 | CAPSULE | 40 mg | ORAL | ANDA | 31 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7198 | CAPSULE | 40 mg | ORAL | ANDA | 31 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0721 | SOLUTION | 20 mg | ORAL | ANDA | 33 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0721 | SOLUTION | 20 mg | ORAL | ANDA | 33 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-4721 | SOLUTION | 20 mg | ORAL | ANDA | 33 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-4721 | SOLUTION | 20 mg | ORAL | ANDA | 33 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-1384 | CAPSULE | 10 mg | ORAL | ANDA | 33 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7625 | CAPSULE | 20 mg | ORAL | ANDA | 32 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7638 | CAPSULE | 10 mg | ORAL | ANDA | 32 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8093 | CAPSULE | 10 mg | ORAL | ANDA | 32 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8183 | CAPSULE | 40 mg | ORAL | ANDA | 33 sections |
Prozac | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0777-3104 | CAPSULE | 10 mg | ORAL | NDA | 35 sections |
Prozac | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0777-3105 | CAPSULE | 20 mg | ORAL | NDA | 35 sections |
Prozac | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0777-3107 | CAPSULE | 40 mg | ORAL | NDA | 35 sections |
Fluoxetine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2822 | CAPSULE | 20 mg | ORAL | ANDA | 31 sections |
Fluoxetine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2823 | CAPSULE | 10 mg | ORAL | ANDA | 31 sections |
Fluoxetine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2824 | CAPSULE | 40 mg | ORAL | ANDA | 31 sections |