fluoxetine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives 1209 54910-89-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prozac
  • fluoxetine
  • fluoxetine hydrochloride
  • fluoxetin
  • fluoxetine HCl
The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
  • Molecular weight: 309.33
  • Formula: C17H18F3NO
  • CLOGP: 4.57
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 21.26
  • ALOGS: -5.26
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 14 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 1.25 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 4.30 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
fu (Fraction unbound in plasma) 0.02 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.030 Moderate 0.69
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.625 Moderate 0.69
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 28.840 10^-6 cm/s Moderate 0.69
dh-clint Dog hepatocyte intrinsic clearance 5.768 uL/min/10^6 cells Moderate 0.69
dppb Dog plasma protein binding (% unbound) 6.930 % Moderate 0.69
fcs-ppb Fetal calf serum protein binding (% unbound) 19.820 % Moderate 0.69
herg hERG pIC50 6.028 pIC50 Moderate 0.69
hh-clint Human hepatocyte intrinsic clearance 1.419 uL/min/10^6 cells Moderate 0.69
hlm-clint Human liver microsomal intrinsic clearance 3.459 uL/min/mg protein Moderate 0.69
hppb Human plasma protein binding (% unbound) 11.580 % Moderate 0.69
kinase-safety-class ACVR2B,AKT1,BRAF,BTK,CAMK2D,CDK4,CDK5,EIF2AK3,GRK2,ITK,JAK3,MAPK10,MET,NTRK2,PDK2,PDK4,TGFBR1 17
kinase-selectivity-class EIF2AK3,PDK4 2
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.951 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.135 Moderate 0.69
mh-clint Mouse hepatocyte intrinsic clearance 9.750 Moderate 0.69
mppb Mouse plasma protein binding (% unbound) 6.210 Moderate 0.69
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 3.020 Moderate 0.69
pfas-class PFAS structural alert (1 = True, 0 = False) 1
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
pppb Pig plasma protein binding (% unbound) 13.930 % Moderate 0.69
rat-kpuu-brain Rat brain Kpuu 0.600 % High 1
rh-clint Rat hepatocyte intrinsic clearance 17.539 uL/min/10^6 cells Moderate 0.69
rh-fuinc Rat hepatocyte fraction unbound in incubation 12.910 % Moderate 0.69
rppb Rat plasma protein binding (% unbound) 8.660 % Moderate 0.69
solubility-dd Solubility at pH 7.4 in DMSO 946.237 uM Moderate 0.69

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1987 FDA ELI LILLY AND CO

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2598.93 9.85 2189 173114 142869 90310275
Intentional overdose 1824.79 9.85 1486 173817 92348 90360796
Toxicity to various agents 1699.62 9.85 2418 172885 285428 90167716
Suicidal ideation 1309.27 9.85 1109 174194 72746 90380398
Serotonin syndrome 1218.23 9.85 813 174490 37074 90416070
Suicide attempt 1108.05 9.85 1018 174285 74381 90378763
Drug interaction 1037.49 9.85 1891 173412 274562 90178582
Intentional self-injury 872.65 9.85 600 174703 28734 90424410
Drug abuse 826.34 9.85 904 174399 81443 90371701
Electrocardiogram QT prolonged 666.10 9.85 760 174543 71696 90381448
Systemic lupus erythematosus 549.65 9.85 39 175264 361857 90091287
Hand deformity 536.33 9.85 7 175296 296355 90156789
Tremor 530.09 9.85 1013 174290 152160 90300984
Synovitis 520.27 9.85 29 175274 329723 90123421
Cardio-respiratory arrest 506.85 9.85 618 174685 62522 90390622
Glossodynia 454.94 9.85 47 175256 321732 90131412
Infusion related reaction 440.27 9.85 130 175173 416650 90036494
Pericarditis 434.78 9.85 21 175282 270130 90183014
Wound 423.83 9.85 46 175257 302934 90150210
Agitation 409.73 9.85 574 174729 66524 90386620
Somnolence 398.45 9.85 1092 174211 207992 90245152
Duodenal ulcer perforation 388.70 9.85 8 175295 221280 90231864
Joint swelling 386.53 9.85 249 175054 503051 89950093
Helicobacter infection 380.57 9.85 13 175290 226837 90226307
Respiratory arrest 355.49 9.85 378 174925 32933 90420211
Contraindicated product administered 352.62 9.85 92 175211 320047 90133097
Folliculitis 348.94 9.85 10 175293 204343 90248801
Arthropathy 343.98 9.85 139 175164 366103 90087041
Anxiety 332.80 9.85 1332 173971 308440 90144704
Cardiac arrest 332.51 9.85 669 174634 104266 90348878
Alopecia 320.08 9.85 292 175011 494779 89958365
Overdose 318.75 9.85 842 174461 156867 90296277
Hepatic enzyme increased 316.51 9.85 151 175152 360585 90092559
Rheumatoid factor positive 310.66 9.85 4 175299 171646 90281498
Swelling 305.99 9.85 219 175084 418839 90034305
Drug withdrawal syndrome 301.31 9.85 323 174980 28400 90424744
Poisoning 297.40 9.85 242 175061 14975 90438169
Muscle injury 296.70 9.85 10 175293 176644 90276500
Impaired healing 284.61 9.85 54 175249 234145 90218999
Treatment failure 284.26 9.85 116 175187 303812 90149332
Withdrawal syndrome 277.24 9.85 276 175027 22248 90430896
Abdominal discomfort 267.39 9.85 318 174985 477010 89976134
Coma 264.23 9.85 491 174812 72141 90381003
Blister 257.51 9.85 86 175217 254912 90198232
Irritability 251.03 9.85 327 174976 35335 90417809
Reversible cerebral vasoconstriction syndrome 243.46 9.85 131 175172 3999 90449145
Seizure 241.33 9.85 746 174557 151883 90301261
Poisoning deliberate 233.04 9.85 218 175085 16268 90436876
Stomatitis 230.32 9.85 122 175181 274576 90178568
Lower respiratory tract infection 228.99 9.85 99 175204 250560 90202584
Sleep disorder due to general medical condition, insomnia type 220.75 9.85 6 175297 128688 90324456
Peripheral swelling 218.94 9.85 287 175016 412819 90040325
Torsade de pointes 205.50 9.85 196 175107 14986 90438158
Joint range of motion decreased 204.62 9.85 15 175288 135628 90317516
Disturbance in attention 202.96 9.85 343 174960 46766 90406378
Rash 202.75 9.85 823 174480 795277 89657867
Therapeutic product effect decreased 202.53 9.85 145 175158 277426 90175718
Akathisia 200.43 9.85 169 175134 10990 90442154
Discomfort 199.26 9.85 144 175159 274191 90178953
Depression 199.15 9.85 1124 174179 299477 90153667
Mobility decreased 197.78 9.85 120 175183 250614 90202530
Irritable bowel syndrome 197.46 9.85 77 175226 207371 90245773
Drug intolerance 195.93 9.85 354 174949 447237 90005907
Sopor 195.70 9.85 240 175063 24404 90428740
Depressed level of consciousness 195.63 9.85 434 174869 72350 90380794
Nightmare 194.64 9.85 225 175078 21500 90431644
Type 2 diabetes mellitus 192.52 9.85 76 175227 203168 90249976
General physical health deterioration 189.88 9.85 245 175058 354870 90098274
Depressed mood 188.29 9.85 344 174959 49878 90403266
Respiratory depression 186.43 9.85 188 175115 15387 90437757
Ill-defined disorder 185.49 9.85 63 175240 184828 90268316
Infection 185.30 9.85 258 175045 361836 90091308
Aggression 174.55 9.85 236 175067 26432 90426712
Suspected suicide 174.11 9.85 146 175157 9422 90443722
Product use issue 172.90 9.85 231 175072 329688 90123456
Lip dry 172.06 9.85 5 175298 100950 90352194
Facet joint syndrome 170.96 9.85 4 175299 98385 90354759
Generalised tonic-clonic seizure 167.73 9.85 267 175036 34636 90418508
Gastrointestinal disorder 163.74 9.85 153 175150 256534 90196610
Fibromyalgia 162.26 9.85 99 175204 206170 90246974
Suicidal behaviour 161.49 9.85 88 175215 2756 90450388
Panic attack 160.06 9.85 225 175078 26140 90427004
Mydriasis 159.52 9.85 170 175133 14842 90438302
Mania 159.10 9.85 165 175138 13959 90439185
Rheumatoid arthritis 157.54 9.85 288 175015 362326 90090818
Bezoar 156.36 9.85 85 175218 2649 90450495
Nasopharyngitis 155.83 9.85 348 174955 406756 90046388
Bursitis 154.37 9.85 33 175270 131621 90321523
Psoriatic arthropathy 154.18 9.85 129 175174 228206 90224938
Crying 149.99 9.85 215 175088 25430 90427714
C-reactive protein increased 149.87 9.85 82 175221 181307 90271837
Arthralgia 147.33 9.85 893 174410 777629 89675515
Electrocardiogram QRS complex prolonged 141.78 9.85 116 175187 7232 90445912
Foetal exposure during pregnancy 137.24 9.85 275 175028 42700 90410444
Major depression 134.77 9.85 129 175174 9906 90443238
Grip strength decreased 134.72 9.85 12 175291 92564 90360580
Peripheral venous disease 133.39 9.85 7 175296 83914 90369230
Product substitution issue 132.79 9.85 169 175134 17839 90435305
Sedation 132.55 9.85 290 175013 47881 90405263
Febrile neutropenia 131.66 9.85 71 175232 158278 90294866
Inflammation 126.70 9.85 96 175207 178496 90274648
Product complaint 126.31 9.85 143 175160 13357 90439787
Intentional product use issue 126.11 9.85 140 175163 216752 90236392
Extrapyramidal disorder 124.99 9.85 156 175147 16147 90436997
Muscle twitching 124.44 9.85 191 175112 24011 90429133
Swollen tongue 123.43 9.85 274 175029 45682 90407462
Wound infection 122.05 9.85 28 175275 106374 90346770
Metabolic acidosis 121.36 9.85 306 174997 55370 90397774
Tachycardia 113.96 9.85 604 174699 157069 90296075
Dystonia 113.36 9.85 151 175152 16668 90436476
Galactorrhoea 112.33 9.85 84 175219 4588 90448556
Liver injury 111.91 9.85 99 175204 170468 90282676
Hallucination, auditory 110.10 9.85 145 175158 15830 90437314
Tardive dyskinesia 109.52 9.85 120 175183 10810 90442334
Muscle rigidity 108.23 9.85 136 175167 14173 90438971
Hyperhidrosis 107.45 9.85 535 174768 135770 90317374
Pyrexia 105.64 9.85 796 174507 659689 89793455
White blood cell count abnormal 105.61 9.85 99 175204 7405 90445739
Paranoia 104.58 9.85 127 175176 12781 90440363
Abnormal behaviour 104.48 9.85 170 175133 22458 90430686
Drug dependence 103.80 9.85 196 175107 29131 90424013
Pneumonia 102.49 9.85 768 174535 637291 89815853
Hypersensitivity 102.13 9.85 492 174811 454185 89998959
Sinus bradycardia 101.90 9.85 144 175159 16808 90436336
Restlessness 101.65 9.85 218 175085 35502 90417642
Anger 101.55 9.85 129 175174 13591 90439553
Myoclonus 100.99 9.85 153 175150 19015 90434129
Dyskinesia 100.57 9.85 220 175083 36314 90416830
Miosis 100.06 9.85 107 175196 9377 90443767
Coma scale abnormal 98.57 9.85 84 175219 5542 90447602
Wheezing 98.15 9.85 195 175108 237885 90215259
Musculoskeletal pain 96.86 9.85 113 175190 171138 90282006
Sinusitis 96.55 9.85 340 174963 342748 90110396
Osteoarthritis 96.53 9.85 143 175160 195587 90257557
Blood lactic acid decreased 95.78 9.85 35 175268 407 90452737
Mood swings 94.87 9.85 155 175148 20547 90432597
Pulmonary fibrosis 94.14 9.85 45 175258 107458 90345686
Antidepressant drug level increased 91.79 9.85 33 175270 365 90452779
Self-injurious ideation 91.65 9.85 64 175239 3139 90450005
Restless legs syndrome 90.72 9.85 159 175144 22311 90430833
Hyperreflexia 90.20 9.85 86 175217 6571 90446573
Hypotension 90.00 9.85 994 174309 324403 90128741
Intentional product misuse 89.41 9.85 377 174926 89227 90363917
Obsessive-compulsive disorder 88.78 9.85 72 175231 4432 90448712
Acute respiratory distress syndrome 88.54 9.85 181 175122 28505 90424639
Therapeutic product effect incomplete 87.73 9.85 150 175153 193746 90259398
Hip arthroplasty 87.51 9.85 20 175283 76188 90376956
Hypercholesterolaemia 87.18 9.85 43 175260 100849 90352295
Red blood cell sedimentation rate increased 86.61 9.85 26 175277 82569 90370575
Swelling face 86.46 9.85 349 174954 81003 90372141
Blood cholesterol increased 86.05 9.85 170 175133 207842 90245302
Bradypnoea 84.59 9.85 71 175232 4587 90448557
Autoimmune disorder 84.49 9.85 22 175281 76722 90376422
Dysphonia 84.02 9.85 291 175012 62793 90390351
Liver disorder 83.70 9.85 67 175236 121202 90331942
Tearfulness 82.99 9.85 71 175232 4709 90448435
Feeling abnormal 82.91 9.85 581 174722 166654 90286490
Antipsychotic drug level increased 82.18 9.85 64 175239 3715 90449429
Vitamin B1 decreased 82.11 9.85 33 175270 505 90452639
Dermatitis atopic 81.99 9.85 156 175147 23316 90429828
Parkinsonism 80.90 9.85 117 175186 13948 90439196
Adjustment disorder with depressed mood 80.86 9.85 8 175295 56745 90396399
Hyponatraemia 80.27 9.85 487 174816 133051 90320093
Oedema 79.19 9.85 168 175135 200127 90253017
Cardiac output increased 78.73 9.85 32 175271 505 90452639
Unresponsive to stimuli 78.40 9.85 205 175098 37916 90415228
Liver function test increased 78.25 9.85 33 175270 84822 90368322
Myelosuppression 77.82 9.85 7 175296 53584 90399560
Emotional distress 77.29 9.85 199 175104 36463 90416681
Bone erosion 76.79 9.85 7 175296 53014 90400130
Therapeutic response unexpected 75.91 9.85 145 175158 21735 90431409
Stress cardiomyopathy 75.23 9.85 110 175193 13245 90439899
Libido increased 74.96 9.85 45 175258 1699 90451445
Dissociation 74.83 9.85 78 175225 6637 90446507
Prescribed underdose 74.45 9.85 26 175277 74993 90378151
Clonus 73.61 9.85 72 175231 5678 90447466
Hostility 73.54 9.85 49 175254 2224 90450920
Hyperlactacidaemia 72.96 9.85 62 175241 4074 90449070
Mood altered 72.73 9.85 124 175179 17020 90436124
Abnormal dreams 72.72 9.85 99 175204 11158 90441986
Drug withdrawal syndrome neonatal 72.65 9.85 49 175254 2270 90450874
Cholecystitis chronic 72.11 9.85 92 175211 9734 90443410
Pain 71.52 9.85 1429 173874 994912 89458232
Hypertonia neonatal 71.43 9.85 25 175278 254 90452890
Knee arthroplasty 71.04 9.85 36 175267 83146 90369998
Live birth 70.99 9.85 32 175271 79075 90374069
Alcohol interaction 69.60 9.85 43 175260 1711 90451433
Hyperprolactinaemia 69.49 9.85 68 175235 5365 90447779
Tic 68.68 9.85 44 175259 1867 90451277
Complication of device insertion 67.75 9.85 92 175211 10344 90442800
Hypersexuality 67.51 9.85 30 175273 596 90452548
Multiple sclerosis 67.03 9.85 159 175144 27681 90425463
Nail disorder 66.83 9.85 16 175287 59051 90394093
Onychomadesis 66.81 9.85 6 175297 45992 90407152
Bradyphrenia 66.78 9.85 78 175225 7534 90445610
Mental disorder 64.63 9.85 172 175131 32146 90420998
Sinus tachycardia 64.53 9.85 159 175144 28354 90424790
Gait inability 63.80 9.85 116 175187 146340 90306804
Depressive symptom 63.62 9.85 64 175239 5221 90447923
Catatonia 63.32 9.85 68 175235 5988 90447156
Lung disorder 63.27 9.85 121 175182 149762 90303382
Speech disorder 63.08 9.85 213 175090 45372 90407772
Stress 63.07 9.85 318 174985 81077 90372067
Loss of consciousness 63.05 9.85 476 174827 139762 90313382
Sciatica 62.76 9.85 62 175241 101320 90351824
Thrombocytopenia 62.67 9.85 201 175102 208524 90244620
Lethargy 62.47 9.85 265 175038 62874 90390270
Musculoskeletal stiffness 62.44 9.85 328 174975 296204 90156940
Physical deconditioning 62.42 9.85 44 175259 2191 90450953
Drug ineffective for unapproved indication 61.57 9.85 274 175029 66370 90386774
Inappropriate antidiuretic hormone secretion 61.29 9.85 124 175179 19381 90433763
Disease progression 60.54 9.85 133 175170 156482 90296662
Dependence 60.27 9.85 42 175261 2053 90451091
Impulsive behaviour 60.12 9.85 39 175264 1691 90451453
Pulseless electrical activity 59.90 9.85 80 175223 8852 90444292
Neutropenia 59.85 9.85 228 175075 224676 90228468
Angioedema 59.38 9.85 266 175037 64610 90388534
Sulphaemoglobinaemia 58.95 9.85 26 175277 507 90452637
Cerebral vasoconstriction 58.71 9.85 34 175269 1200 90451944
Brugada syndrome 58.51 9.85 25 175278 450 90452694
Malignant neoplasm progression 57.78 9.85 73 175230 106797 90346347
Dysarthria 57.30 9.85 233 175070 54249 90398895
Rhabdomyolysis 56.95 9.85 223 175080 51033 90402111
Maternal exposure during pregnancy 56.92 9.85 435 174868 359628 90093516
Atrial septal defect 55.60 9.85 74 175229 8160 90444984
Blepharospasm 55.39 9.85 19 175284 55426 90397718
Respiration abnormal 54.44 9.85 72 175231 7891 90445253
Hallucination 54.16 9.85 262 175041 65697 90387447
Drug hypersensitivity 53.90 9.85 605 174698 463004 89990140
Prescribed overdose 53.50 9.85 66 175237 97559 90355585
Night sweats 52.58 9.85 106 175197 128660 90324484
Pre-eclampsia 52.36 9.85 84 175219 10964 90442180
Hypertonia 52.35 9.85 57 175246 5098 90448046
Anorgasmia 52.19 9.85 26 175277 674 90452470
Multiple sclerosis relapse 52.11 9.85 220 175083 52085 90401059
Decorticate posture 52.10 9.85 21 175282 324 90452820
Myocardial depression 51.64 9.85 25 175278 608 90452536
Hypotonia neonatal 51.58 9.85 33 175270 1397 90451747
Lower limb fracture 51.47 9.85 53 175250 84960 90368184
Fear 51.43 9.85 105 175198 16517 90436627
Soft tissue injury 51.16 9.85 38 175265 2054 90451090
Mental impairment 51.01 9.85 105 175198 16615 90436529
Taste disorder 50.55 9.85 28 175275 61518 90391626
Sternal fracture 50.36 9.85 43 175260 2844 90450300
Fall 50.15 9.85 1253 174050 480557 89972587
Oculogyric crisis 49.65 9.85 40 175263 2439 90450705
Psychotic disorder 49.62 9.85 153 175150 31077 90422067
Maternal drugs affecting foetus 48.90 9.85 55 175248 5100 90448044
Urinary incontinence 48.90 9.85 172 175131 37394 90415750
Coeliac disease 48.70 9.85 13 175290 44597 90408547
Accidental death 47.41 9.85 36 175267 2012 90451132
Talipes 46.75 9.85 33 175270 1647 90451497
Arthritis 46.22 9.85 167 175136 167148 90285996
Ventricular fibrillation 46.19 9.85 91 175212 13953 90439191
Off label use 45.81 9.85 1708 173595 1100544 89352600
Ventricular hypokinesia 45.64 9.85 54 175249 5287 90447857
Blood prolactin increased 45.55 9.85 45 175258 3592 90449552
Heart sounds 45.28 9.85 28 175275 1116 90452028
Hallucination, visual 45.27 9.85 122 175181 22970 90430174
Maternal exposure during breast feeding 45.27 9.85 58 175245 6162 90446982
Neuroleptic malignant syndrome 45.11 9.85 94 175209 15002 90438142
Euphoric mood 45.09 9.85 54 175249 5355 90447789
Drug level increased 45.03 9.85 137 175166 27625 90425519
Dyspnoea 44.34 9.85 1332 173971 879623 89573521
Concussion 44.15 9.85 78 175225 11013 90442131
Bulimia nervosa 44.05 9.85 21 175282 493 90452651
Abortion missed 44.04 9.85 34 175269 1948 90451196
Disorientation 43.52 9.85 185 175118 43929 90409215
Long QT syndrome 43.39 9.85 46 175257 3991 90449153
Loss of libido 43.10 9.85 29 175274 1338 90451806
Urticaria 42.99 9.85 392 174911 312342 90140802
Prolonged expiration 42.86 9.85 28 175275 1229 90451915
Onychomycosis 42.53 9.85 10 175293 37366 90415778
Agitation neonatal 42.48 9.85 21 175282 535 90452609
Vertigo 42.19 9.85 255 175048 69556 90383588
Drug tolerance decreased 42.13 9.85 6 175297 32124 90421020
Morbid thoughts 41.90 9.85 23 175280 731 90452413
Apathy 41.84 9.85 76 175227 10964 90442180
Vitamin B1 increased 41.80 9.85 15 175288 165 90452979
Accidental overdose 41.70 9.85 135 175168 28138 90425006
Binge eating 40.81 9.85 21 175282 584 90452560
Persistent genital arousal disorder 40.69 9.85 22 175281 678 90452466
Blood hyposmosis 40.61 9.85 10 175293 23 90453121
Obesity 40.44 9.85 90 175213 105417 90347727
Laryngitis 40.38 9.85 24 175279 50729 90402415
Pancytopenia 40.28 9.85 110 175193 120153 90332991
Eosinophilic pneumonia acute 40.25 9.85 22 175281 693 90452451
Poor quality sleep 40.19 9.85 122 175181 24571 90428573
Anhedonia 39.95 9.85 76 175227 11355 90441789
Infantile apnoea 39.85 9.85 27 175276 1260 90451884
Drug-induced liver injury 39.80 9.85 71 175232 90247 90362897
Borderline personality disorder 39.66 9.85 25 175278 1031 90452113
Breast cancer stage II 39.14 9.85 10 175293 35324 90417820
Finger deformity 39.05 9.85 8 175295 32889 90420255
Post-traumatic neck syndrome 38.95 9.85 35 175268 2479 90450665
Adverse event 38.88 9.85 108 175195 117310 90335834
Hypomania 38.60 9.85 65 175238 8832 90444312
Physical assault 38.44 9.85 23 175280 863 90452281
Cogwheel rigidity 38.09 9.85 32 175271 2070 90451074
Breech presentation 37.86 9.85 26 175277 1241 90451903
Drug ineffective 37.73 9.85 2244 173059 1382054 89071090
Platelet count decreased 37.63 9.85 137 175166 136832 90316312
Lupus-like syndrome 37.61 9.85 24 175279 48822 90404322
Insomnia 37.60 9.85 877 174426 332597 90120547
Salivary hypersecretion 37.56 9.85 65 175238 9027 90444117
Balance disorder 37.34 9.85 318 174985 96762 90356382
Traumatic coma 37.20 9.85 11 175292 61 90453083
Ataxia 37.07 9.85 97 175206 17945 90435199
Cerebral microhaemorrhage 36.95 9.85 15 175288 236 90452908
Atrioventricular block first degree 36.68 9.85 62 175241 8449 90444695
Foot deformity 36.32 9.85 37 175266 59614 90393530
Panic reaction 35.94 9.85 45 175258 4672 90448472
Vision blurred 35.67 9.85 348 174955 109945 90343199
Hyperthermia 35.25 9.85 68 175235 10267 90442877
Mucosal inflammation 34.79 9.85 36 175267 57589 90395555
Influenza like illness 34.76 9.85 271 175032 80340 90372804
Somnambulism 34.65 9.85 51 175252 6177 90446967
Pulmonary embolism 34.45 9.85 396 174907 130424 90322720
Neonatal hypoxia 34.40 9.85 20 175283 711 90452433
Electrocardiogram abnormal 34.20 9.85 67 175236 10231 90442913
Psychomotor hyperactivity 33.95 9.85 76 175227 12737 90440407
Thinking abnormal 33.83 9.85 72 175231 11660 90441484
Dry mouth 33.66 9.85 213 175090 183846 90269298
Protein C increased 33.44 9.85 10 175293 58 90453086
Emotional disorder 33.27 9.85 83 175220 14914 90438230
Contusion 33.17 9.85 318 174985 250898 90202246
Drug abuser 33.16 9.85 33 175270 2657 90450487
Substance use disorder 33.04 9.85 29 175274 1991 90451153
Nervousness 32.96 9.85 142 175161 33914 90419230
Hypersomnia 32.83 9.85 104 175199 21427 90431717
Depression suicidal 32.68 9.85 29 175274 2020 90451124
Breast enlargement 32.38 9.85 27 175276 1728 90451416
Alcohol poisoning 32.38 9.85 28 175275 1884 90451260
Drug use disorder 32.34 9.85 58 175245 8285 90444859
Exostosis 32.30 9.85 33 175270 53101 90400043
Disinhibition 32.11 9.85 22 175281 1046 90452098
Libido decreased 32.09 9.85 34 175269 2948 90450196
Dyspepsia 31.94 9.85 238 175065 197922 90255222
Osteoporosis 31.80 9.85 89 175214 96442 90356702
Alcoholism 31.79 9.85 27 175276 1773 90451371
Electrocardiogram repolarisation abnormality 31.44 9.85 24 175279 1352 90451792
Gallbladder disorder 31.44 9.85 97 175206 19706 90433438
Increased appetite 31.42 9.85 70 175233 11695 90441449
Blood pressure fluctuation 31.36 9.85 33 175270 52380 90400764
Affective disorder 31.27 9.85 55 175248 7738 90445406
Eosinophilic pneumonia chronic 31.26 9.85 13 175290 218 90452926
Abdominal pain upper 31.23 9.85 454 174849 332220 90120924
Psychomotor retardation 30.75 9.85 42 175261 4747 90448397
Cytomegalovirus infection 30.50 9.85 7 175296 26595 90426549
Bipolar disorder 30.50 9.85 59 175244 8926 90444218
Cholecystectomy 30.34 9.85 69 175234 11686 90441458
Vasoplegia syndrome 30.13 9.85 32 175271 2782 90450362
Emotional poverty 30.10 9.85 15 175288 389 90452755
Personality change 29.80 9.85 52 175251 7269 90445875
Heart disease congenital 29.67 9.85 25 175278 1624 90451520
Pre-existing condition improved 29.66 9.85 59 175244 9110 90444034
Urinary retention 29.61 9.85 148 175155 37596 90415548
Hallucinations, mixed 29.60 9.85 46 175257 5843 90447301
Dizziness 29.53 9.85 1408 173895 587876 89865268
Injury 29.49 9.85 242 175061 197107 90256037
Delusion of grandeur 29.31 9.85 13 175290 257 90452887
Hypothermia 29.25 9.85 81 175222 15494 90437650
Persistent foetal circulation 29.09 9.85 12 175291 197 90452947
Leukocytosis 29.06 9.85 128 175175 30862 90422282
Social anxiety disorder 28.95 9.85 17 175286 616 90452528
Alcohol use 28.79 9.85 25 175278 1692 90451452
Systolic dysfunction 28.50 9.85 26 175277 1878 90451266
Breast discomfort 28.48 9.85 17 175286 635 90452509
Heavy menstrual bleeding 28.46 9.85 96 175207 20434 90432710
Cystostomy 28.41 9.85 9 175294 65 90453079
Bone marrow oedema syndrome 28.41 9.85 9 175294 65 90453079
Bradycardia 28.32 9.85 267 175036 83580 90369564
Ulcer haemorrhage 28.11 9.85 8 175295 26313 90426831
Feeling guilty 28.10 9.85 17 175286 651 90452493
Asthma 28.10 9.85 316 174987 241844 90211300
Dysphoria 28.09 9.85 46 175257 6108 90447036
Attention-seeking behaviour 28.06 9.85 9 175294 68 90453076
Anaemia 27.94 9.85 497 174806 352305 90100839
Patent ductus arteriosus 27.74 9.85 39 175264 4530 90448614
Hypertonic bladder 27.72 9.85 38 175265 4310 90448834
Respiratory disorder 27.63 9.85 52 175251 64764 90388380
Bruxism 27.62 9.85 38 175265 4325 90448819
Posture abnormal 27.57 9.85 30 175273 2681 90450463
Self-destructive behaviour 27.35 9.85 15 175288 476 90452668
Drug screen positive 27.29 9.85 35 175268 3722 90449422
Amenorrhoea 27.20 9.85 66 175237 11656 90441488
Back injury 27.17 9.85 30 175273 46592 90406552
Blood pressure measurement 27.12 9.85 14 175289 392 90452752
Device placement issue 27.08 9.85 26 175277 2004 90451140
Burning mouth syndrome 27.07 9.85 16 175287 587 90452557
Epilepsy 26.93 9.85 76 175227 82130 90371014
Mental status changes 26.86 9.85 163 175140 44516 90408628
Flat affect 26.86 9.85 24 175279 1687 90451457
Respiratory disorder neonatal 26.78 9.85 22 175281 1379 90451765
Yawning 26.75 9.85 20 175283 1092 90452052
Renal impairment 26.67 9.85 109 175194 105312 90347832
Diarrhoea 26.64 9.85 1516 173787 937674 89515470
Walking aid user 26.58 9.85 18 175285 35488 90417656
Product administration interrupted 26.53 9.85 68 175235 12424 90440720
Trichotillomania 26.50 9.85 10 175293 128 90453016
Cerebral microinfarction 26.43 9.85 6 175297 8 90453136
Pulmonary valve stenosis 26.42 9.85 14 175289 414 90452730
Small for dates baby 26.42 9.85 40 175263 4967 90448177
Formication 26.32 9.85 39 175264 4752 90448392
Disability 26.29 9.85 24 175279 40721 90412423
Sleep-related eating disorder 26.28 9.85 19 175284 985 90452159
Menstruation irregular 26.23 9.85 52 175251 8008 90445136
Meningorrhagia 26.21 9.85 11 175292 189 90452955
Marital problem 26.05 9.85 11 175292 192 90452952
Induced abortion failed 25.95 9.85 11 175292 194 90452950
Abortion spontaneous 25.71 9.85 186 175117 53870 90399274
Altered state of consciousness 25.70 9.85 125 175178 31407 90421737
Joint stiffness 25.67 9.85 72 175231 77970 90375174
Joint dislocation 25.64 9.85 29 175274 44553 90408591
Fluid retention 25.61 9.85 86 175217 88005 90365139
Pleurothotonus 25.60 9.85 21 175282 1314 90451830
Pyramidal tract syndrome 25.53 9.85 15 175288 544 90452600
Blood potassium decreased 25.52 9.85 169 175134 47558 90405586
Eating disorder symptom 25.50 9.85 10 175293 143 90453001
Feeling drunk 25.09 9.85 38 175265 4720 90448424
Narcolepsy 25.07 9.85 22 175281 1510 90451634
Feeling jittery 25.07 9.85 76 175227 15295 90437849
Non-cardiogenic pulmonary oedema 25.05 9.85 20 175283 1204 90451940
Distributive shock 25.03 9.85 32 175271 3392 90449752
Hepatic cirrhosis 25.03 9.85 53 175250 63200 90389944
Colitis microscopic 25.01 9.85 62 175241 11097 90442047
Gestational diabetes 25 9.85 60 175243 10522 90442622
Self esteem decreased 24.99 9.85 17 175286 799 90452345
Food allergy 24.98 9.85 9 175294 25469 90427675
Middle insomnia 24.71 9.85 80 175223 16671 90436473
Bipolar I disorder 24.67 9.85 25 175278 2057 90451087
Hypokalaemia 24.54 9.85 373 174930 130743 90322401
Neoplasm progression 24.45 9.85 30 175273 44456 90408688
Optic ischaemic neuropathy 24.44 9.85 23 175280 1729 90451415
Porphyria acute 24.42 9.85 3 175300 17972 90435172
Ideas of reference 24.15 9.85 9 175294 111 90453033
Homicidal ideation 24.12 9.85 23 175280 1757 90451387
Blood lactate dehydrogenase increased 24.04 9.85 10 175293 25922 90427222
Appetite disorder 24.01 9.85 54 175249 9079 90444065
Diet failure 23.95 9.85 7 175296 37 90453107
Pulmonary haemosiderosis 23.91 9.85 5 175298 3 90453141
Ventricular tachycardia 23.89 9.85 103 175200 24605 90428539
Macular degeneration 23.75 9.85 23 175280 37947 90415197
Echolalia 23.74 9.85 12 175291 321 90452823
Adverse reaction 23.71 9.85 14 175289 29698 90423446
Lactic acidosis 23.64 9.85 173 175130 50290 90402854
Pulmonary valve stenosis congenital 23.51 9.85 10 175293 178 90452966
Ventricular arrhythmia 23.48 9.85 35 175268 4286 90448858
Treatment noncompliance 23.47 9.85 176 175127 51551 90401593
Developmental delay 23.10 9.85 22 175281 1678 90451466
Exposure during pregnancy 22.99 9.85 614 174689 237796 90215348
CYP3A4 polymorphism 22.97 9.85 8 175295 80 90453064
Decreased interest 22.96 9.85 35 175268 4372 90448772
Mediastinitis 22.95 9.85 12 175291 345 90452799
Dysphemia 22.93 9.85 29 175274 3041 90450103
Attention deficit hyperactivity disorder 22.90 9.85 34 175269 4150 90448994
Neonatal complications of substance abuse 22.79 9.85 5 175298 5 90453139
Aortic bruit 22.74 9.85 6 175297 20 90453124
Agoraphobia 22.73 9.85 14 175289 554 90452590
Hypoaesthesia 22.60 9.85 450 174853 313760 90139384
Supraventricular tachyarrhythmia 22.54 9.85 8 175295 85 90453059
IIIrd nerve paresis 22.26 9.85 9 175294 140 90453004
Atrial fibrillation 22.23 9.85 159 175144 133452 90319692
Reduced facial expression 22.13 9.85 26 175277 2527 90450617
Prolonged rupture of membranes 22.05 9.85 7 175296 51 90453093
Cardiac failure 21.98 9.85 123 175180 109373 90343771
Blood creatinine increased 21.96 9.85 111 175192 101275 90351869
Obsessive thoughts 21.85 9.85 14 175289 594 90452550
Neuropathy peripheral 21.83 9.85 165 175138 136805 90316339
Cholelithiasis 21.80 9.85 175 175128 52331 90400813
Bladder dilatation 21.66 9.85 17 175286 998 90452146
Product dose omission issue 21.58 9.85 727 174576 290960 90162184
Communication disorder 21.51 9.85 29 175274 3237 90449907
Foreign body in reproductive tract 21.50 9.85 18 175285 1159 90451985
Eye movement disorder 21.41 9.85 41 175262 6157 90446987
Incubator therapy 21.37 9.85 7 175296 57 90453087
Gastric bypass 21.36 9.85 23 175280 2031 90451113
Foetal alcohol syndrome 21.32 9.85 6 175297 27 90453117
Ventricular extrasystoles 21.13 9.85 65 175238 13185 90439959
Posterior segment of eye anomaly congenital 21 9.85 4 175299 0 90453144
Energy increased 20.94 9.85 28 175275 3102 90450042
Analgesic drug level increased 20.90 9.85 27 175276 2892 90450252
Device material issue 20.86 9.85 12 175291 418 90452726
Procedural hypertension 20.71 9.85 11 175292 327 90452817
Neurodevelopmental disorder 20.66 9.85 10 175293 243 90452901
Tongue biting 20.65 9.85 23 175280 2110 90451034
Chronic fatigue syndrome 20.64 9.85 20 175283 1559 90451585
Blood magnesium decreased 20.55 9.85 72 175231 15621 90437523
Gambling disorder 20.53 9.85 18 175285 1234 90451910
Oedema peripheral 20.51 9.85 363 174940 257552 90195592
Slow response to stimuli 20.51 9.85 17 175286 1079 90452065
Negative thoughts 20.50 9.85 17 175286 1080 90452064
Procedural pneumothorax 20.47 9.85 7 175296 66 90453078
Primitive reflex test positive 20.46 9.85 5 175298 11 90453133
Ear infection 20.36 9.85 68 175235 69707 90383437
Maternal exposure timing unspecified 20.32 9.85 9 175294 22474 90430670
Inadequate analgesia 20.29 9.85 28 175275 3196 90449948
Autonomic nervous system imbalance 20.28 9.85 29 175274 3421 90449723
Placenta praevia 20.12 9.85 17 175286 1108 90452036
Septic shock 20.07 9.85 89 175214 84071 90369073
Pupillary disorder 20.01 9.85 10 175293 261 90452883
Anal incontinence 20 9.85 73 175230 16157 90436987
Gaze palsy 19.99 9.85 20 175283 1621 90451523
Atrioventricular block second degree 19.95 9.85 33 175270 4419 90448725
Infusion site reaction 19.94 9.85 6 175297 19033 90434111
Dermatillomania 19.94 9.85 10 175293 263 90452881
Cytokine release syndrome 19.87 9.85 15 175288 27958 90425186
Sudden onset of sleep 19.87 9.85 13 175290 572 90452572
Electrocardiogram QT shortened 19.84 9.85 9 175294 188 90452956
Premature labour 19.84 9.85 64 175239 13312 90439832
Serum sickness-like reaction 19.81 9.85 13 175290 575 90452569
Sudden cardiac death 19.79 9.85 23 175280 2209 90450935
Apnoea 19.74 9.85 51 175252 9363 90443781
Neonatal disorder 19.73 9.85 13 175290 579 90452565
Herpes zoster 19.72 9.85 105 175198 94539 90358605
Syncope 19.55 9.85 363 174940 132300 90320844
Postural orthostatic tachycardia syndrome 19.46 9.85 23 175280 2249 90450895
Anterograde amnesia 19.39 9.85 13 175290 596 90452548
Vaginal haemorrhage 19.38 9.85 115 175188 31156 90421988
Nystagmus 19.30 9.85 43 175260 7184 90445960
Phobia 19.29 9.85 11 175292 377 90452767
Prolonged labour 19.28 9.85 13 175290 602 90452542
Plasma cell mastitis 19.23 9.85 6 175297 41 90453103
Subarachnoid haemorrhage 19.16 9.85 77 175226 17827 90435317
Frequent bowel movements 19.12 9.85 52 175251 56883 90396261
Vanishing bile duct syndrome 19.11 9.85 18 175285 1354 90451790
Foetal arrhythmia 19.01 9.85 9 175294 208 90452936
Potentiating drug interaction 19.00 9.85 37 175266 5625 90447519
Hypertension 18.88 9.85 709 174594 456823 89996321
Purple glove syndrome 18.81 9.85 9 175294 213 90452931
Hypoxic-ischaemic encephalopathy 18.80 9.85 33 175270 4635 90448509
pH body fluid increased 18.77 9.85 4 175299 3 90453141
Alcohol withdrawal syndrome 18.70 9.85 15 175288 909 90452235
Regurgitation 18.68 9.85 22 175281 2144 90451000
Post-traumatic stress disorder 18.65 9.85 41 175262 6787 90446357
Biliary dyskinesia 18.55 9.85 24 175279 2575 90450569
Bone marrow failure 18.49 9.85 21 175282 32200 90420944
Atelectasis neonatal 18.44 9.85 5 175298 19 90453125
Spinal shock 18.44 9.85 5 175298 19 90453125
Food interaction 18.41 9.85 17 175286 1247 90451897
Oppositional defiant disorder 18.41 9.85 6 175297 48 90453096
Breast pain 18.41 9.85 53 175250 10365 90442779
Thrombotic microangiopathy 18.33 9.85 4 175299 15739 90437405
Transient aphasia 18.30 9.85 6 175297 49 90453095
Polydactyly 18.30 9.85 10 175293 315 90452829
Menopausal symptoms 18.28 9.85 26 175277 3052 90450092
Rib fracture 18.21 9.85 100 175203 26335 90426809
Psychotic behaviour 18.17 9.85 13 175290 663 90452481
Heart rate 18.08 9.85 9 175294 233 90452911
Female genital tract fistula 18.06 9.85 6 175297 17862 90435282
Trismus 18.03 9.85 33 175270 4788 90448356
Antidepressant discontinuation syndrome 18.00 9.85 8 175295 159 90452985
Pain in extremity 17.96 9.85 701 174602 449828 90003316
Theft 17.92 9.85 7 175296 99 90453045
Staring 17.90 9.85 19 175284 1651 90451493
Substance-induced psychotic disorder 17.89 9.85 25 175278 2887 90450257
Hypercalcaemia 17.87 9.85 24 175279 34216 90418928
Cleft palate 17.83 9.85 17 175286 1299 90451845
Acute myopia 17.77 9.85 8 175295 164 90452980
Congenital brain damage 17.77 9.85 4 175299 5 90453139
Spontaneous haematoma 17.70 9.85 16 175287 1142 90452002
Bradykinesia 17.69 9.85 40 175263 6748 90446396
Enuresis 17.63 9.85 27 175276 3387 90449757
Cataplexy 17.56 9.85 18 175285 1502 90451642
Jaundice neonatal 17.53 9.85 15 175288 995 90452149
Proctitis 17.52 9.85 4 175299 15255 90437889
Arrhythmia 17.52 9.85 141 175162 42191 90410953
Agonal rhythm 17.51 9.85 5 175298 24 90453120
Tension 17.46 9.85 28 175275 3654 90449490
Angle closure glaucoma 17.31 9.85 24 175279 2751 90450393
Neonatal asphyxia 17.26 9.85 10 175293 353 90452791
Dysmorphism 17.22 9.85 23 175280 2545 90450599
Foetal monitoring abnormal 17.21 9.85 9 175294 259 90452885
Pruritus 17.20 9.85 864 174439 540661 89912483
Erythema 17.18 9.85 326 174977 228920 90224224
Prescription drug used without a prescription 17.17 9.85 26 175277 3229 90449915
Antipsychotic drug level above therapeutic 17.10 9.85 17 175286 1367 90451777
Toxic encephalopathy 17.09 9.85 46 175257 8653 90444491
Polyneuropathy 17.07 9.85 8 175295 19333 90433811
Congenital gastric anomaly 17.02 9.85 5 175298 27 90453117
Head injury 17.02 9.85 111 175192 31077 90422067
Sleep paralysis 16.95 9.85 14 175289 884 90452260
Blunted affect 16.93 9.85 9 175294 268 90452876
Medical observation 16.74 9.85 8 175295 189 90452955
Sleep apnoea syndrome 16.72 9.85 112 175191 31635 90421509
Fatigue 16.62 9.85 1967 173336 1152056 89301088
Maternal exposure via partner during pregnancy 16.62 9.85 4 175299 8 90453136
Panic disorder 16.60 9.85 25 175278 3090 90450054
Dysgeusia 16.58 9.85 165 175138 52395 90400749
Ventricular septal defect 16.54 9.85 34 175269 5373 90447771
Sluggishness 16.53 9.85 36 175267 5923 90447221
Road traffic accident 16.52 9.85 131 175172 107495 90345649
Electrolyte depletion 16.51 9.85 8 175295 195 90452949
Affect lability 16.48 9.85 74 175229 17989 90435155
Sleep attacks 16.43 9.85 7 175296 125 90453019
Oesophageal food impaction 16.42 9.85 9 175294 285 90452859
Inhibitory drug interaction 16.31 9.85 25 175278 3138 90450006
Anorexia nervosa 16.28 9.85 9 175294 290 90452854
Areflexia 16.26 9.85 27 175276 3626 90449518
Panniculitis 16.19 9.85 4 175299 14454 90438690
Umbilical cord around neck 16.14 9.85 8 175295 205 90452939
Oesophageal achalasia 16.04 9.85 12 175291 656 90452488
Mononucleosis syndrome 15.97 9.85 8 175295 210 90452934
Hypometabolism 15.92 9.85 5 175298 35 90453109
Posterior reversible encephalopathy syndrome 15.84 9.85 12 175291 22327 90430817
Tachyphrenia 15.84 9.85 18 175285 1688 90451456
Intrusive thoughts 15.83 9.85 10 175293 414 90452730
Malformation venous 15.75 9.85 3 175300 0 90453144
Confabulation 15.71 9.85 9 175294 311 90452833
Immunodeficiency 15.66 9.85 38 175265 43196 90409948
Dysuria 15.64 9.85 130 175173 39271 90413873
Hypokinesia 15.61 9.85 66 175237 15631 90437513
Therapy non-responder 15.61 9.85 179 175124 136525 90316619
Cold agglutinins positive 15.56 9.85 5 175298 38 90453106
Gestational hypertension 15.51 9.85 24 175279 3038 90450106
Acidosis 15.45 9.85 57 175246 12679 90440465
Drug eruption 15.45 9.85 28 175275 35379 90417765
Colitis ulcerative 15.44 9.85 62 175241 60204 90392940
Complication of device removal 15.36 9.85 36 175267 6219 90446925
Single umbilical artery 15.33 9.85 9 175294 326 90452818
Hunger 15.28 9.85 37 175266 6526 90446618
Abnormal sleep-related event 15.25 9.85 13 175290 858 90452286
Tooth hypoplasia 15.22 9.85 6 175297 87 90453057
Lactation disorder 15.20 9.85 10 175293 444 90452700
Alkalosis 15.17 9.85 11 175292 573 90452571
Parkinsonian gait 15.03 9.85 11 175292 581 90452563
Abnormal uterine bleeding 15.02 9.85 19 175284 1993 90451151
Blood pressure systolic increased 14.96 9.85 60 175243 58285 90394859
Creatinine renal clearance decreased 14.94 9.85 9 175294 18890 90434254
Urinary hesitation 14.92 9.85 21 175282 2442 90450702
Aspiration 14.85 9.85 65 175238 15628 90437516
Pelvic pain 14.83 9.85 64 175239 15293 90437851
Hypoprolactinaemia 14.80 9.85 4 175299 15 90453129
Depersonalisation/derealisation disorder 14.78 9.85 17 175286 1615 90451529
Sleep disorder 14.71 9.85 282 175021 197748 90255396
Feeling of despair 14.69 9.85 24 175279 3180 90449964
Cold sweat 14.63 9.85 60 175243 14021 90439123
Gastritis 14.62 9.85 134 175169 41619 90411525
Blood triglycerides increased 14.58 9.85 59 175244 13702 90439442
Product deposit 14.57 9.85 9 175294 358 90452786
Craniosynostosis 14.54 9.85 7 175296 168 90452976
Compulsive shopping 14.54 9.85 12 175291 757 90452387
Decreased appetite 14.54 9.85 588 174715 375952 90077192
Ectopic pregnancy 14.49 9.85 24 175279 3217 90449927
Unmasking of previously unidentified disease 14.43 9.85 16 175287 1460 90451684
Blood pressure systolic abnormal 14.41 9.85 10 175293 19468 90433676
Leukopenia 14.36 9.85 125 175178 100585 90352559
Basilar migraine 14.27 9.85 5 175298 51 90453093
Pleural effusion 14.25 9.85 143 175160 111848 90341296
Substance abuse 14.25 9.85 32 175271 5374 90447770
Cytopenia 14.24 9.85 8 175295 17441 90435703
Laboratory test abnormal 14.22 9.85 38 175265 41816 90411328
Medication overuse headache 14.21 9.85 16 175287 1485 90451659
Biliary colic 14.18 9.85 27 175276 4036 90449108
Sleep talking 14.15 9.85 14 175289 1119 90452025
Platelet dysfunction 14.14 9.85 6 175297 106 90453038
Chemical burn 14.06 9.85 10 175293 505 90452639
Obsessive-compulsive symptom 13.99 9.85 6 175297 109 90453035
Long QT syndrome congenital 13.94 9.85 6 175297 110 90453034
Headache 13.94 9.85 1888 173415 860858 89592286
Oesophageal adenocarcinoma 13.93 9.85 7 175296 185 90452959
Duodenal ulcer repair 13.85 9.85 5 175298 56 90453088
Loss of bladder sensation 13.77 9.85 5 175298 57 90453087
Disturbance in sexual arousal 13.77 9.85 8 175295 284 90452860
Joint hyperextension 13.76 9.85 9 175294 396 90452748
Fear of weight gain 13.71 9.85 4 175299 21 90453123
Facial paralysis 13.69 9.85 63 175240 15471 90437673
Pregnancy with advanced maternal age 13.68 9.85 3 175300 3 90453141
Electrocardiogram QT interval 13.62 9.85 7 175296 194 90452950
Delusion 13.62 9.85 58 175245 13782 90439362
Neonatal respiratory distress 13.55 9.85 11 175292 678 90452466
Electrocardiogram T wave inversion 13.51 9.85 25 175278 3658 90449486
Acute myeloid leukaemia 13.50 9.85 12 175291 20628 90432516
Electrocardiogram QRS complex shortened 13.44 9.85 10 175293 542 90452602
Polydipsia 13.41 9.85 27 175276 4204 90448940
Micturition urgency 13.40 9.85 50 175253 11183 90441961
Bacteraemia 13.38 9.85 14 175289 22286 90430858
Psychiatric symptom 13.35 9.85 37 175266 7081 90446063
Product physical issue 13.27 9.85 32 175271 5628 90447516
Hyporesponsive to stimuli 13.25 9.85 16 175287 1601 90451543
Victim of crime 13.23 9.85 12 175291 860 90452284
Drooling 13.22 9.85 28 175275 4518 90448626
Device expulsion 13.21 9.85 129 175174 40757 90412387
Floppy infant 13.20 9.85 6 175297 126 90453018
General physical condition abnormal 13.19 9.85 30 175273 5081 90448063
Extensor plantar response 13.15 9.85 15 175288 1412 90451732
Carbon monoxide poisoning 13.12 9.85 7 175296 210 90452934
Salpingo-oophorectomy bilateral 13.08 9.85 9 175294 431 90452713
Haematotoxicity 13.04 9.85 4 175299 12531 90440613
Haemodynamic instability 12.98 9.85 51 175252 11688 90441456
Pupillary reflex impaired 12.96 9.85 20 175283 2525 90450619
Hypnopompic hallucination 12.85 9.85 5 175298 70 90453074
Polyarthritis 12.83 9.85 10 175293 18340 90434804
Disorganised speech 12.82 9.85 17 175286 1868 90451276
Hyperacusis 12.81 9.85 21 175282 2790 90450354
Pulmonary valve incompetence 12.75 9.85 16 175287 1665 90451479
Medical diet 12.74 9.85 4 175299 28 90453116
Bradycardia neonatal 12.73 9.85 13 175290 1080 90452064
Rubber sensitivity 12.67 9.85 21 175282 2816 90450328
Breath sounds abnormal 12.63 9.85 7 175296 15379 90437765
Physical examination abnormal 12.62 9.85 6 175297 140 90453004
Premature rupture of membranes 12.58 9.85 31 175272 5527 90447617
Dilatation ventricular 12.56 9.85 19 175284 2357 90450787
Palpitations 12.56 9.85 350 174953 136378 90316766
Blood parathyroid hormone decreased 12.53 9.85 4 175299 12212 90440932
Therapeutic response decreased 12.51 9.85 112 175191 89617 90363527
Pregnancy on oral contraceptive 12.51 9.85 13 175290 1102 90452042
Renal adenoma 12.47 9.85 3 175300 6 90453138
Hyperinsulinism 12.47 9.85 3 175300 6 90453138
Thought insertion 12.47 9.85 3 175300 6 90453138
Muscle enzyme increased 12.46 9.85 7 175296 233 90452911
Ventricular hypertrophy 12.42 9.85 23 175280 3368 90449776
Brain injury 12.37 9.85 38 175265 7700 90445444
Hepatitis 12.35 9.85 83 175220 70656 90382488
Social avoidant behaviour 12.31 9.85 23 175280 3390 90449754
Spondylitis 12.31 9.85 6 175297 14172 90438972
Joint effusion 12.26 9.85 12 175291 19698 90433446
Metastases to bone 12.21 9.85 19 175284 25486 90427658
Antidepressant drug level above therapeutic 12.21 9.85 9 175294 481 90452663
Gallbladder hypofunction 12.17 9.85 9 175294 483 90452661
Hepatic steatosis 12.15 9.85 117 175186 36828 90416316
Body height increased 12.13 9.85 5 175298 82 90453062
Eosinophil count decreased 12.03 9.85 22 175281 3190 90449954
Ear pain 12.03 9.85 64 175239 57638 90395506
Dissociative identity disorder 12.02 9.85 5 175298 84 90453060
Electrocardiogram ST segment elevation 11.99 9.85 25 175278 3991 90449153
Status migrainosus 11.96 9.85 6 175297 158 90452986
Caesarean section 11.96 9.85 69 175234 18508 90434636
Bundle branch block right 11.91 9.85 30 175273 5423 90447721
Tremor neonatal 11.89 9.85 6 175297 160 90452984
Pustular psoriasis 11.89 9.85 11 175292 18545 90434599
Infantile vomiting 11.85 9.85 6 175297 161 90452983
Anticholinergic syndrome 11.85 9.85 20 175283 2723 90450421
Microcephaly 11.84 9.85 14 175289 1370 90451774
Hypouricaemia 11.84 9.85 7 175296 257 90452887
Cough 11.83 9.85 588 174715 368374 90084770
Amaurosis 11.78 9.85 11 175292 819 90452325
Muscle neoplasm 11.76 9.85 4 175299 37 90453107
Brucellosis 11.75 9.85 5 175298 89 90453055
Metastases to central nervous system 11.72 9.85 10 175293 17532 90435612
Hypoxia 11.69 9.85 201 175102 72198 90380946
Dissociative amnesia 11.67 9.85 4 175299 38 90453106
Spasmodic dysphonia 11.65 9.85 5 175298 91 90453053
Essential tremor 11.61 9.85 14 175289 1398 90451746
Right ventricular hypertension 11.61 9.85 3 175300 9 90453135
Carotid arterial embolus 11.61 9.85 3 175300 9 90453135
Tooth demineralisation 11.61 9.85 3 175300 9 90453135
Gallbladder neoplasm 11.58 9.85 4 175299 39 90453105
Tinnitus 11.58 9.85 131 175172 42971 90410173
Enterocolitis 11.56 9.85 3 175300 10487 90442657
Encephalopathy 11.51 9.85 139 175164 46305 90406839
Osteonecrosis of jaw 11.48 9.85 38 175265 39065 90414079
Asphyxia 11.47 9.85 35 175268 7068 90446076
Toxic epidermal necrolysis 11.46 9.85 29 175274 32499 90420645
Antisocial personality disorder 11.37 9.85 3 175300 10 90453134
Hypotonia 11.33 9.85 48 175255 11378 90441766
Bronchiectasis 11.31 9.85 16 175287 22314 90430830
Respiratory acidosis 11.28 9.85 38 175265 8081 90445063
Sensation of blood flow 11.27 9.85 5 175298 99 90453045
Dysstasia 11.23 9.85 85 175218 24967 90428177
Pupil fixed 11.23 9.85 17 175286 2111 90451033
Feeling of body temperature change 11.23 9.85 30 175273 5619 90447525
Breast discharge 11.21 9.85 13 175290 1246 90451898
Pleural disorder 11.15 9.85 10 175293 706 90452438
Arnold-Chiari malformation 11.13 9.85 10 175293 708 90452436
Withdrawal catatonia 11.10 9.85 6 175297 185 90452959
Derealisation 11.05 9.85 14 175289 1471 90451673
Lymphocytic hypophysitis 11.03 9.85 7 175296 292 90452852
Blood pressure diastolic decreased 11.02 9.85 22 175281 26804 90426340
Snoring 10.98 9.85 28 175275 5098 90448046
Intermenstrual bleeding 10.96 9.85 41 175262 9182 90443962
Exposure via ingestion 10.93 9.85 19 175284 2648 90450496
Respiratory alkalosis 10.93 9.85 22 175281 3426 90449718
Lymphatic system neoplasm 10.91 9.85 4 175299 47 90453097
Skin necrosis 10.90 9.85 10 175293 16931 90436213
Haemorrhage in pregnancy 10.89 9.85 17 175286 2168 90450976
Hyperthermia malignant 10.89 9.85 13 175290 1285 90451859
Pulse absent 10.89 9.85 31 175272 6024 90447120
Circulatory collapse 10.88 9.85 84 175219 24820 90428324
Liver function test abnormal 10.84 9.85 148 175155 50697 90402447
Grandiosity 10.82 9.85 7 175296 302 90452842
Asthenia 10.82 9.85 887 174416 532864 89920280
Conduction disorder 10.82 9.85 15 175288 1720 90451424
Gingival discomfort 10.81 9.85 8 175295 430 90452714
Screaming 10.80 9.85 23 175280 3727 90449417
Food craving 10.79 9.85 16 175287 1951 90451193
Verbal abuse 10.79 9.85 5 175298 110 90453034
Bipolar II disorder 10.78 9.85 8 175295 432 90452712
Pregnancy with contraceptive patch 10.75 9.85 3 175300 13 90453131
Coagulation factor decreased 10.75 9.85 6 175297 197 90452947
Myocarditis 10.73 9.85 54 175249 13752 90439392
Menstruation normal 10.67 9.85 6 175297 200 90452944
Death of relative 10.65 9.85 8 175295 440 90452704
Embolic stroke 10.62 9.85 24 175279 4048 90449096
Mutism 10.59 9.85 15 175288 1754 90451390
Product administered to patient of inappropriate age 10.58 9.85 26 175277 4627 90448517
Labour induction 10.58 9.85 5 175298 115 90453029
Uterine hypertonus 10.58 9.85 7 175296 314 90452830
Generalised anxiety disorder 10.52 9.85 19 175284 2728 90450416
Economic problem 10.48 9.85 21 175282 3260 90449884
Periodic limb movement disorder 10.47 9.85 9 175294 601 90452543
Pyloric stenosis 10.46 9.85 8 175295 452 90452692
Coordination abnormal 10.45 9.85 74 175229 21282 90431862
Hyporeflexia 10.43 9.85 17 175286 2249 90450895
Ketonuria 10.41 9.85 10 175293 771 90452373
Brain stem haematoma 10.40 9.85 3 175300 15 90453129
Hypertrophic scar 10.40 9.85 3 175300 15 90453129
Purpura senile 10.40 9.85 9 175294 606 90452538
Craniocerebral injury 10.40 9.85 21 175282 3277 90449867
Neonatal seizure 10.38 9.85 9 175294 608 90452536
Cholesterosis 10.37 9.85 8 175295 458 90452686
Pneumonia aspiration 10.36 9.85 123 175180 40817 90412327
Panniculitis lobular 10.34 9.85 4 175299 55 90453089
Blood creatine phosphokinase increased 10.34 9.85 106 175197 33917 90419227
Developmental hip dysplasia 10.33 9.85 14 175289 1571 90451573
Abortion induced 10.32 9.85 48 175255 11840 90441304
Alpha 1 globulin increased 10.31 9.85 5 175298 122 90453022
Blood pressure diastolic abnormal 10.31 9.85 14 175289 19867 90433277
Adrenal insufficiency 10.29 9.85 27 175276 29894 90423250
Alcohol intolerance 10.28 9.85 5 175298 123 90453021
Impulse-control disorder 10.22 9.85 11 175292 971 90452173
Nail pitting 10.21 9.85 7 175296 333 90452811
Superior mesenteric artery syndrome 10.20 9.85 5 175298 125 90453019
Torticollis 10.19 9.85 18 175285 2540 90450604
Transplant rejection 10.19 9.85 6 175297 12752 90440392
Renal tubular acidosis 10.16 9.85 17 175286 2298 90450846
Electrocardiogram ST segment abnormal 10.15 9.85 12 175291 1174 90451970
Intentional dose omission 10.14 9.85 64 175239 17719 90435425
Basal cell carcinoma 10.12 9.85 32 175271 33357 90419787
Cardiomegaly 10.11 9.85 67 175236 18858 90434286
Tenosynovitis 10.11 9.85 8 175295 14559 90438585
Peritonitis 10.10 9.85 14 175289 19691 90433453
Pulmonary vasculitis 10.06 9.85 6 175297 224 90452920
Compulsive sexual behaviour 10.03 9.85 4 175299 60 90453084
Apgar score low 10.01 9.85 12 175291 1191 90451953
Respiratory tract congestion 10.00 9.85 24 175279 27386 90425758
Locked-in syndrome 9.98 9.85 8 175295 484 90452660
Initial insomnia 9.93 9.85 40 175263 9270 90443874
Therapy change 9.89 9.85 37 175266 8285 90444859
Resorption bone increased 9.88 9.85 12 175291 1207 90451937
Crohn's disease 9.88 9.85 26 175277 4825 90448319
Cardiac output decreased 9.88 9.85 11 175292 1009 90452135
Acute stress disorder 9.87 9.85 7 175296 352 90452792
Palmar-plantar erythrodysaesthesia syndrome 9.86 9.85 25 175278 27998 90425146

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 1386.97 11.09 744 73947 25101 42521543
Suicide attempt 614.34 11.09 564 74127 45536 42501108
Intentional overdose 595.08 11.09 582 74109 50874 42495770
Completed suicide 585.80 11.09 781 73910 95684 42450960
Toxicity to various agents 585.09 11.09 1258 73433 227878 42318766
Drug interaction 521.83 11.09 1320 73371 265679 42280965
Suicidal ideation 507.53 11.09 518 74173 47643 42499001
Obsessive-compulsive disorder 383.49 11.09 202 74489 6541 42540103
Akathisia 347.98 11.09 221 74470 10230 42536414
Euphoric mood 283.38 11.09 163 74528 6290 42540354
Antipsychotic drug level below therapeutic 265.47 11.09 124 74567 3080 42543564
Drug abuse 250.16 11.09 561 74130 104210 42442434
Disinhibition 245.37 11.09 125 74566 3770 42542874
Therapeutic product effect variable 244.29 11.09 116 74575 2993 42543651
Aggression 223.49 11.09 328 74363 43835 42502809
Agitation 217.40 11.09 398 74293 63916 42482728
Increased appetite 207.43 11.09 151 74540 8755 42537889
Overdose 197.92 11.09 514 74177 104750 42441894
Anxiety 183.33 11.09 539 74152 118021 42428623
Irritability 181.55 11.09 235 74456 27893 42518751
Homicide 177.27 11.09 65 74626 850 42545794
Febrile neutropenia 176.74 11.09 53 74638 185650 42360994
Obesity 169.50 11.09 175 74516 16284 42530360
Drug dependence 141.27 11.09 212 74479 28882 42517762
Drug withdrawal syndrome 137.43 11.09 179 74512 21370 42525274
Depression 136.12 11.09 467 74224 110896 42435748
Tardive dyskinesia 129.48 11.09 103 74588 6821 42539823
Electrocardiogram QT prolonged 127.11 11.09 268 74423 47677 42498967
Antidepressant drug level increased 112.50 11.09 33 74658 199 42546445
Intentional self-injury 112.43 11.09 136 74555 15066 42531578
Extrapyramidal disorder 107.26 11.09 138 74553 16274 42530370
Anaemia 105.85 11.09 207 74484 280071 42266573
Antipsychotic drug level increased 103.88 11.09 77 74614 4589 42542055
Priapism 102.40 11.09 87 74604 6320 42540324
Pneumonia 102.22 11.09 388 74303 421761 42124883
Mania 101.19 11.09 108 74583 10439 42536205
Major depression 98.16 11.09 79 74612 5319 42541325
Weight increased 98.12 11.09 412 74279 107571 42439073
Malignant neoplasm progression 95.92 11.09 35 74656 108365 42438279
Exposure during pregnancy 95.50 11.09 95 74596 8453 42538191
Pyrexia 94.83 11.09 363 74328 393679 42152965
Depressed mood 92.27 11.09 155 74536 23229 42523415
Sepsis 92.14 11.09 129 74562 199205 42347439
Drug withdrawal syndrome neonatal 89.11 11.09 69 74622 4392 42542252
Sedation 88.60 11.09 177 74514 30298 42516346
Disease progression 87.36 11.09 74 74617 143582 42403062
Tremor 86.63 11.09 368 74323 96561 42450083
Poisoning 82.87 11.09 115 74576 14584 42532060
Paranoia 80.98 11.09 111 74580 13915 42532729
Psychotic disorder 80.58 11.09 166 74525 29042 42517602
Generalised tonic-clonic seizure 77.63 11.09 154 74537 26225 42520419
Anger 76.63 11.09 104 74587 12914 42533730
Suicidal behaviour 75.84 11.09 42 74649 1504 42545140
Dyskinesia 75.65 11.09 149 74542 25241 42521403
Thrombocytopenia 74.85 11.09 137 74554 190142 42356502
Victim of child abuse 74.42 11.09 38 74653 1151 42545493
Platelet count decreased 74.20 11.09 80 74611 138501 42408143
Leukaemia 73.62 11.09 69 74622 5703 42540941
Respiratory depression 73.03 11.09 124 74567 18744 42527900
Epidural lipomatosis 72.50 11.09 43 74648 1757 42544887
Sexual dysfunction 71.48 11.09 73 74618 6702 42539942
Choreoathetosis 71.04 11.09 36 74655 1073 42545571
Social avoidant behaviour 69.31 11.09 53 74638 3311 42543333
Muscle twitching 69.17 11.09 94 74597 11686 42534958
Disturbance in attention 68.98 11.09 158 74533 29708 42516936
Tic 68.55 11.09 46 74645 2337 42544307
Off label use 68.51 11.09 753 73938 637582 41909062
Physical deconditioning 68.17 11.09 46 74645 2359 42544285
Abnormal behaviour 66.78 11.09 145 74546 26306 42520338
Juvenile idiopathic arthritis 66.62 11.09 47 74644 2592 42544052
Hyperreflexia 66.04 11.09 53 74638 3554 42543090
Penile abscess 65.02 11.09 20 74671 145 42546499
Hallucination, auditory 64.69 11.09 103 74588 14761 42531883
General physical health deterioration 63.93 11.09 104 74587 151142 42395502
Prescribed overdose 63.88 11.09 95 74596 12832 42533812
Child abuse 63.17 11.09 31 74660 861 42545783
Diarrhoea 62.39 11.09 513 74178 460336 42086308
Dyslipidaemia 61.23 11.09 79 74612 9339 42537305
Pancytopenia 60.79 11.09 70 74621 117673 42428971
Homicidal ideation 59.73 11.09 45 74646 2749 42543895
Foetal exposure during pregnancy 59.12 11.09 200 74491 47111 42499533
Panic attack 58.68 11.09 84 74607 10961 42535683
Obsessive-compulsive symptom 58.32 11.09 20 74671 212 42546432
Decerebrate posture 58.22 11.09 18 74673 133 42546511
Dissociation 57.50 11.09 50 74641 3748 42542896
Insomnia 57.23 11.09 379 74312 117874 42428770
Neuroleptic malignant syndrome 56.84 11.09 120 74571 21352 42525292
Myelosuppression 55.44 11.09 4 74687 40457 42506187
Dystonia 54.80 11.09 88 74603 12702 42533942
Schizoaffective disorder 54.22 11.09 37 74654 1933 42544711
Cytokine release syndrome 54.19 11.09 7 74684 44520 42502124
Metabolic acidosis 52.73 11.09 205 74486 51653 42494991
Withdrawal syndrome 51.84 11.09 93 74598 14682 42531962
Neutropenia 51.59 11.09 178 74513 199253 42347391
Rhabdomyolysis 51.25 11.09 271 74420 77748 42468896
Bruxism 51.01 11.09 37 74654 2132 42544512
Mucosal inflammation 50.86 11.09 12 74679 49362 42497282
Asphyxia 49.74 11.09 67 74624 8259 42538385
Infection 48.34 11.09 76 74615 111992 42434652
Neonatal respiratory distress syndrome 48.29 11.09 49 74642 4464 42542180
Renal impairment 48.26 11.09 74 74617 110154 42436490
Synaesthesia 48.14 11.09 9 74682 0 42546644
Parasomnia 47.88 11.09 21 74670 448 42546196
Atrial fibrillation 47.64 11.09 109 74582 139484 42407160
Drug abuser 46.56 11.09 43 74648 3488 42543156
Bipolar disorder 46.44 11.09 45 74646 3877 42542767
Rash 46.26 11.09 290 74401 276664 42269980
Hepatic function abnormal 45.00 11.09 17 74674 51550 42495094
Myoclonus 44.74 11.09 95 74596 16970 42529674
Small for dates baby 43.75 11.09 50 74641 5213 42541431
Mental disorder 43.43 11.09 97 74594 17932 42528712
Apathy 43.30 11.09 63 74628 8343 42538301
Haemoglobin decreased 43.16 11.09 106 74585 132365 42414279
Electrocardiogram QRS complex prolonged 42.89 11.09 52 74639 5771 42540873
Torsade de pointes 42.23 11.09 63 74628 8531 42538113
Intentional product misuse 42.02 11.09 217 74474 61683 42484961
Coma 41.52 11.09 195 74496 53359 42493285
Hyperhidrosis 41.32 11.09 286 74405 90226 42456418
Depersonalisation/derealisation disorder 40.68 11.09 21 74670 651 42545993
Septic shock 40.65 11.09 61 74630 91611 42455033
Yawning 40.44 11.09 22 74669 760 42545884
Hallucination 40.01 11.09 203 74488 57304 42489340
Maternal drugs affecting foetus 39.84 11.09 41 74650 3798 42542846
Neuropathy peripheral 39.41 11.09 74 74617 101779 42444865
Drug level increased 39.33 11.09 118 74573 26082 42520562
Derealisation 38.61 11.09 22 74669 833 42545811
Mood swings 38.18 11.09 61 74630 8765 42537879
Seizure 38.08 11.09 350 74341 120211 42426433
Tremor neonatal 37.35 11.09 18 74673 480 42546164
Psychomotor hyperactivity 37.20 11.09 68 74623 10890 42535754
Cytomegalovirus infection 37.16 11.09 6 74685 32300 42514344
Premature baby 36.40 11.09 106 74585 23047 42523597
Eye movement disorder 36.17 11.09 44 74647 4901 42541743
Loss of libido 35.93 11.09 35 74656 3035 42543609
Stomatitis 35.68 11.09 22 74669 50307 42496337
Clonus 35.46 11.09 37 74654 3483 42543161
Parkinsonism 34.90 11.09 65 74626 10558 42536086
Impulsive behaviour 34.86 11.09 31 74660 2394 42544250
Chorea 34.80 11.09 25 74666 1419 42545225
Abnormal sleep-related event 34.62 11.09 17 74674 473 42546171
Oculogyric crisis 34.60 11.09 27 74664 1738 42544906
COVID-19 34.54 11.09 97 74594 115851 42430793
Restless legs syndrome 34.35 11.09 61 74630 9553 42537091
Jaw clicking 34.27 11.09 10 74681 59 42546585
Pulmonary embolism 34.22 11.09 102 74589 119510 42427134
Delusion 34.07 11.09 78 74613 14656 42531988
Hypoglycaemia neonatal 33.96 11.09 29 74662 2121 42544523
Mucosal prolapse syndrome 33.68 11.09 7 74684 5 42546639
Compulsive sexual behaviour 33.45 11.09 14 74677 265 42546379
Bipolar I disorder 33.26 11.09 20 74671 838 42545806
Thinking abnormal 33.07 11.09 51 74640 7110 42539534
Feeling jittery 32.86 11.09 40 74651 4458 42542186
Abnormal dreams 32.85 11.09 55 74636 8216 42538428
Nervousness 32.81 11.09 73 74618 13459 42533185
Product complaint 32.55 11.09 46 74645 5931 42540713
Vasoplegia syndrome 32.45 11.09 31 74660 2624 42544020
Cholinergic syndrome 32.29 11.09 18 74673 653 42545991
Lethargy 32.25 11.09 165 74526 46725 42499919
Hyperprolactinaemia 32.24 11.09 28 74663 2095 42544549
Mydriasis 31.79 11.09 56 74635 8714 42537930
Restlessness 31.68 11.09 118 74573 29131 42517513
Visceral congestion 31.56 11.09 20 74671 921 42545723
Memory impairment 31.30 11.09 172 74519 50050 42496594
Ascites 31.11 11.09 32 74659 56646 42489998
Tachyphrenia 30.37 11.09 23 74668 1416 42545228
Serum ferritin abnormal 30.27 11.09 13 74678 263 42546381
Persistent foetal circulation 30.22 11.09 14 74677 341 42546303
Attention deficit hyperactivity disorder 30.12 11.09 32 74659 3076 42543568
Poor quality sleep 30.07 11.09 57 74634 9383 42537261
Acute kidney injury 30.06 11.09 458 74233 366879 42179765
Cardiac failure 29.94 11.09 92 74599 106764 42439880
Somnolence 29.81 11.09 378 74313 140727 42405917
Product prescribing error 29.67 11.09 107 74584 26005 42520639
Oral discharge 29.45 11.09 11 74680 152 42546492
Emotional disorder 29.20 11.09 45 74646 6269 42540375
Pleural effusion 29.15 11.09 81 74610 97085 42449559
Sinus tachycardia 29.12 11.09 91 74600 20562 42526082
Self-medication 28.81 11.09 32 74659 3234 42543410
Interstitial lung disease 28.62 11.09 59 74632 78403 42468241
Exposure via breast milk 28.54 11.09 28 74663 2449 42544195
Huntington's disease 28.52 11.09 8 74683 40 42546604
Blood prolactin increased 28.41 11.09 27 74664 2271 42544373
Hypertonia neonatal 28.37 11.09 16 74675 594 42546050
Tumour lysis syndrome 28.28 11.09 3 74688 22228 42524416
Gambling disorder 28.14 11.09 24 74667 1752 42544892
Mast cell activation syndrome 27.75 11.09 13 74678 325 42546319
Arthralgia 27.40 11.09 229 74462 205009 42341635
Neutrophil count decreased 27.33 11.09 43 74648 63372 42483272
Affective disorder 26.90 11.09 42 74649 5918 42540726
White blood cell count decreased 26.87 11.09 101 74590 110295 42436349
Erythema 26.83 11.09 99 74592 108694 42437950
Compulsive shopping 26.74 11.09 14 74677 447 42546197
Neonatal disorder 26.69 11.09 17 74674 790 42545854
Erectile dysfunction 26.56 11.09 100 74591 24813 42521831
Infusion related reaction 26.43 11.09 41 74650 60765 42485879
Pain 26.39 11.09 288 74403 244560 42302084
Congenital aortic valve stenosis 26.21 11.09 10 74681 147 42546497
Libido decreased 25.95 11.09 38 74653 5060 42541584
Negative thoughts 25.86 11.09 16 74675 706 42545938
Full blood count abnormal 25.81 11.09 10 74681 29866 42516778
Haematochezia 25.78 11.09 39 74652 58397 42488247
Disseminated intravascular coagulation 25.58 11.09 6 74685 24788 42521856
Cardiac arrest 25.31 11.09 298 74393 109022 42437622
Illusion 25.22 11.09 18 74673 1011 42545633
Psychiatric symptom 25.14 11.09 34 74657 4207 42542437
Mood altered 25.07 11.09 57 74634 10661 42535983
Herpes zoster 24.88 11.09 19 74672 38858 42507786
Cyanosis neonatal 24.83 11.09 12 74679 322 42546322
Respiratory arrest 24.64 11.09 107 74584 28317 42518327
Violence-related symptom 24.62 11.09 14 74677 528 42546116
Dreamy state 24.60 11.09 6 74685 15 42546629
Neoplasm progression 24.58 11.09 10 74681 28990 42517654
Cough 24.55 11.09 197 74494 177906 42368738
Antisocial behaviour 24.52 11.09 13 74678 426 42546218
Rheumatoid arthritis 24.40 11.09 23 74668 42417 42504227
Hostility 24.12 11.09 16 74675 797 42545847
Multiple organ dysfunction syndrome 24.12 11.09 88 74603 96947 42449697
Colitis 23.68 11.09 28 74663 46544 42500100
Dyspnoea 23.65 11.09 593 74098 442028 42104616
Poor feeding infant 23.61 11.09 16 74675 826 42545818
Prostate cancer 23.61 11.09 26 74665 44617 42502027
Respiratory failure 23.55 11.09 130 74561 128002 42418642
Bradycardia 23.45 11.09 241 74450 85243 42461401
Renal failure 23.17 11.09 152 74539 143574 42403070
Product substitution issue 23.11 11.09 57 74634 11233 42535411
Alcoholism 22.95 11.09 27 74664 2903 42543741
Thrombosis 22.94 11.09 54 74637 68457 42478187
Blunted affect 22.87 11.09 12 74679 385 42546259
Treatment noncompliance 22.79 11.09 128 74563 37544 42509100
Muscle rigidity 22.72 11.09 59 74632 12000 42534644
Rubber sensitivity 22.56 11.09 12 74679 396 42546248
Accommodation disorder 22.53 11.09 11 74680 302 42546342
Joint swelling 22.47 11.09 54 74637 67968 42478676
Schizophrenia 22.38 11.09 54 74637 10496 42536148
Porphyria acute 22.34 11.09 12 74679 404 42546240
C-reactive protein increased 22.17 11.09 49 74642 63511 42483133
Salivary hypersecretion 22.14 11.09 55 74636 10888 42535756
Retrograde ejaculation 22.12 11.09 13 74678 522 42546122
Treatment failure 22.08 11.09 48 74643 62576 42484068
Compulsions 21.87 11.09 10 74681 236 42546408
Poisoning deliberate 21.63 11.09 52 74639 10082 42536562
Death 21.62 11.09 645 74046 470540 42076104
Conversion disorder 21.57 11.09 13 74678 547 42546097
Catatonia 21.54 11.09 39 74652 6200 42540444
Lymphocyte count decreased 21.37 11.09 11 74680 27798 42518846
Abdominal distension 21.36 11.09 60 74631 71675 42474969
Hyperkalaemia 21.32 11.09 71 74620 80387 42466257
Antidepressant therapy 21.27 11.09 5 74686 10 42546634
Somnambulism 21.19 11.09 28 74663 3387 42543257
Hypomania 21.14 11.09 24 74667 2484 42544160
Blood creatinine increased 21.11 11.09 110 74581 109893 42436751
Vascular stenosis 20.96 11.09 9 74682 182 42546462
Drug reaction with eosinophilia and systemic symptoms 20.65 11.09 26 74665 42049 42504595
Unresponsive to stimuli 20.55 11.09 109 74582 31294 42515350
Peripheral swelling 20.43 11.09 85 74606 90185 42456459
Accidental death 20.26 11.09 26 74665 3057 42543587
Hypersomnia 20.23 11.09 64 74627 14554 42532090
Liver disorder 19.98 11.09 24 74667 39620 42507024
Loss of employment 19.95 11.09 12 74679 503 42546141
Hypophosphataemia 19.84 11.09 6 74685 20939 42525705
Disorientation 19.66 11.09 120 74571 36269 42510375
Bronchopulmonary aspergillosis 19.46 11.09 5 74686 19424 42527220
Tubulointerstitial nephritis 19.46 11.09 16 74675 31532 42515112
Neonatal respiratory distress 19.43 11.09 15 74676 950 42545694
Enuresis 19.37 11.09 24 74667 2724 42543920
Genital anaesthesia 19.36 11.09 5 74686 17 42546627
Appendicitis 19.36 11.09 6 74685 20607 42526037
Nightmare 19.32 11.09 91 74600 24921 42521723
Palmar-plantar erythrodysaesthesia syndrome 19.31 11.09 6 74685 20576 42526068
Intentional product use issue 19.30 11.09 63 74628 71770 42474874
Suspected suicide 19.21 11.09 37 74654 6162 42540482
Hypersexuality 19.17 11.09 19 74672 1683 42544961
Serum serotonin decreased 19.16 11.09 4 74687 3 42546641
Pruritus 19.16 11.09 225 74466 188546 42358098
Tearfulness 19.15 11.09 27 74664 3473 42543171
Bone marrow failure 18.95 11.09 18 74673 33075 42513569
Compulsive hoarding 18.93 11.09 5 74686 19 42546625
Pituitary tumour benign 18.93 11.09 15 74676 987 42545657
Congenital aortic valve incompetence 18.85 11.09 8 74683 157 42546487
Obsessive thoughts 18.74 11.09 14 74677 844 42545800
Alcohol use 18.68 11.09 24 74667 2824 42543820
Retinal phototoxicity 18.63 11.09 4 74687 4 42546640
Gastrointestinal haemorrhage 18.59 11.09 98 74593 97628 42449016
Malignant catatonia 18.58 11.09 11 74680 448 42546196
Renal artery thrombosis 18.53 11.09 10 74681 340 42546304
Autonomic nervous system imbalance 18.50 11.09 25 74666 3091 42543553
Flat affect 18.35 11.09 15 74676 1032 42545612
Anticipatory anxiety 18.00 11.09 5 74686 24 42546620
Sinus bradycardia 17.85 11.09 62 74629 14791 42531853
Feeling abnormal 17.85 11.09 194 74497 69592 42477052
Chronic actinic dermatitis 17.83 11.09 5 74686 25 42546619
Carbon monoxide poisoning 17.80 11.09 7 74684 112 42546532
Self-injurious ideation 17.69 11.09 19 74672 1849 42544795
Synovitis 17.66 11.09 3 74688 15564 42531080
Initial insomnia 17.63 11.09 28 74663 4002 42542642
Blood uric acid increased 17.63 11.09 3 74688 15544 42531100
Hyperdynamic left ventricle 17.55 11.09 9 74682 275 42546369
Urinary tract discomfort 17.47 11.09 7 74684 118 42546526
COVID-19 pneumonia 17.44 11.09 8 74683 21605 42525039
Mental status changes 17.42 11.09 130 74561 41985 42504659
Logorrhoea 17.40 11.09 23 74668 2784 42543860
Aspartate aminotransferase increased 17.25 11.09 73 74618 77090 42469554
Coagulation factor VII level decreased 17.15 11.09 7 74684 124 42546520
End stage renal disease 17.10 11.09 4 74687 16554 42530090
Confusional state 17.03 11.09 399 74292 167198 42379446
Bradycardia neonatal 16.97 11.09 16 74675 1332 42545312
Neonatal respiratory acidosis 16.90 11.09 6 74685 71 42546573
Hypomagnesaemia 16.90 11.09 15 74676 28473 42518171
Tourette's disorder 16.83 11.09 6 74685 72 42546572
Selective mutism 16.68 11.09 6 74685 74 42546570
Cataplexy 16.67 11.09 10 74681 417 42546227
Cerebral infarction 16.65 11.09 18 74673 31151 42515493
Orthostatic hypotension 16.63 11.09 101 74590 30469 42516175
Tension 16.54 11.09 21 74670 2443 42544201
Anaemia vitamin B12 deficiency 16.51 11.09 11 74680 552 42546092
Hypoperfusion 16.41 11.09 16 74675 1389 42545255
Blood lactate dehydrogenase increased 16.37 11.09 13 74678 26068 42520576
Muscle necrosis 16.31 11.09 14 74677 1031 42545613
Decreased interest 16.26 11.09 22 74669 2723 42543921
Drug intolerance 16.23 11.09 79 74612 80345 42466299
Hospitalisation 16.20 11.09 71 74620 74259 42472385
Agitation neonatal 16.19 11.09 16 74675 1412 42545232
Basilar migraine 16.13 11.09 4 74687 11 42546633
Blood creatine phosphokinase MB 16.05 11.09 3 74688 0 42546644
Neonatal dyspnoea 16.05 11.09 3 74688 0 42546644
Myelodysplastic syndrome 16.04 11.09 10 74681 22735 42523909
Peripheral venous disease 15.99 11.09 23 74668 3013 42543631
Binge eating 15.97 11.09 7 74684 149 42546495
Haemophagocytic lymphohistiocytosis 15.91 11.09 6 74685 18216 42528428
Transposition of the great vessels 15.89 11.09 10 74681 455 42546189
Lymphopenia 15.88 11.09 9 74682 21554 42525090
Lung disorder 15.86 11.09 38 74653 47885 42498759
Muscle tightness 15.83 11.09 32 74659 5521 42541123
Social anxiety disorder 15.78 11.09 11 74680 595 42546049
Exposure via ingestion 15.71 11.09 19 74672 2103 42544541
Pyloric stenosis 15.65 11.09 13 74678 915 42545729
Phobia 15.64 11.09 7 74684 157 42546487
Coma uraemic 15.61 11.09 5 74686 42 42546602
Sleep apnoea syndrome 15.53 11.09 77 74614 21531 42525113
Amnesia 15.50 11.09 94 74597 28343 42518301
Pain in extremity 15.47 11.09 179 74512 150425 42396219
Cardio-respiratory arrest 15.45 11.09 164 74527 58472 42488172
Hepatic failure 15.33 11.09 27 74664 38073 42508571
Pneumocystis jirovecii pneumonia 15.25 11.09 13 74678 25168 42521476
Feeling guilty 15.23 11.09 9 74682 365 42546279
Chronic kidney disease 15.21 11.09 38 74653 47203 42499441
Urinary retention 15.09 11.09 126 74565 42088 42504556
Arthritis 15.02 11.09 32 74659 42033 42504611
Congenital hand malformation 15.02 11.09 11 74680 643 42546001
Therapeutic product effect incomplete 14.94 11.09 190 74501 70749 42475895
Polyneuropathy 14.92 11.09 7 74684 18654 42527990
Creatinine urine decreased 14.84 11.09 5 74686 50 42546594
Staring 14.81 11.09 16 74675 1567 42545077
Dissociative disorder 14.76 11.09 11 74680 661 42545983
Eye colour change 14.72 11.09 8 74683 276 42546368
Transplant rejection 14.60 11.09 3 74688 13585 42533059
Dysphoria 14.56 11.09 21 74670 2759 42543885
Oedema 14.39 11.09 45 74646 51956 42494688
Hyperbilirubinaemia neonatal 14.36 11.09 12 74679 852 42545792
Neutropenic sepsis 14.34 11.09 5 74686 15941 42530703
Cerebrovascular stenosis 14.32 11.09 6 74685 114 42546530
Otosalpingitis 14.26 11.09 4 74687 20 42546624
Alpha 2 globulin decreased 14.26 11.09 4 74687 20 42546624
Fear 14.26 11.09 47 74644 10918 42535726
Marital problem 14.25 11.09 5 74686 57 42546587
Spina bifida 14.19 11.09 9 74682 415 42546229
Aspergillus infection 14.19 11.09 5 74686 15832 42530812
Pancreatitis necrotising 14.14 11.09 24 74667 3625 42543019
Free androgen index decreased 14.10 11.09 4 74687 21 42546623
Sex hormone binding globulin decreased 14.10 11.09 4 74687 21 42546623
Hypertrophic cardiomyopathy 14.05 11.09 15 74676 1450 42545194
Nausea 14.03 11.09 561 74130 396238 42150406
Productive cough 14.01 11.09 45 74646 51522 42495122
Palatal swelling 13.95 11.09 5 74686 61 42546583
Androgen insensitivity syndrome 13.95 11.09 4 74687 22 42546622
Pupil fixed 13.93 11.09 17 74674 1900 42544744
Panic disorder 13.91 11.09 14 74677 1263 42545381
Wrong dose 13.90 11.09 13 74678 1071 42545573
Grandiosity 13.82 11.09 8 74683 312 42546332
Cardiomegaly 13.69 11.09 62 74629 16704 42529940
Testicular microlithiasis 13.65 11.09 4 74687 24 42546620
Blood luteinising hormone decreased 13.64 11.09 6 74685 129 42546515
Blood bilirubin increased 13.59 11.09 34 74657 42218 42504426
Viral acanthoma 13.51 11.09 4 74687 25 42546619
Inflammatory bowel disease 13.40 11.09 23 74668 3506 42543138
Dehydroepiandrosterone decreased 13.38 11.09 4 74687 26 42546618
Tenderness 13.32 11.09 40 74651 8843 42537801
Speech disorder 13.26 11.09 92 74599 29029 42517615
Therapeutic response unexpected 13.24 11.09 47 74644 11334 42535310
Anaphylactic shock 13.22 11.09 13 74678 23504 42523140
Hypospadias 13.22 11.09 23 74668 3544 42543100
Hepatic steatosis 13.05 11.09 73 74618 21375 42525269
Post 5-alpha-reductase inhibitor syndrome 12.95 11.09 6 74685 146 42546498
Toxic skin eruption 12.89 11.09 4 74687 13726 42532918
Antipsychotic drug level decreased 12.85 11.09 13 74678 1180 42545464
Crying 12.79 11.09 32 74659 6362 42540282
Hypocalcaemic seizure 12.77 11.09 5 74686 79 42546565
Urine calcium/creatinine ratio increased 12.77 11.09 4 74687 31 42546613
Alpha globulin increased 12.76 11.09 3 74688 6 42546638
Galactorrhoea 12.76 11.09 9 74682 496 42546148
Feeling of despair 12.71 11.09 13 74678 1195 42545449
Acute respiratory failure 12.71 11.09 31 74660 38827 42507817
Psoriatic arthropathy 12.70 11.09 15 74676 24952 42521692
Hypothyroidism 12.67 11.09 23 74668 32061 42514583
Alcohol problem 12.66 11.09 5 74686 81 42546563
Transaminases increased 12.61 11.09 24 74667 32861 42513783
Hypogonadism male 12.59 11.09 8 74683 370 42546274
Blood glucose fluctuation 12.56 11.09 26 74665 4561 42542083
Prostatic specific antigen increased 12.56 11.09 7 74684 16918 42529726
Self esteem decreased 12.49 11.09 9 74682 513 42546131
Dysphemia 12.43 11.09 16 74675 1886 42544758
Arnold-Chiari malformation 12.40 11.09 8 74683 380 42546264
Affect lability 12.36 11.09 24 74667 4020 42542624
Alcohol abuse 12.34 11.09 24 74667 4025 42542619
Pneumonitis 12.34 11.09 35 74656 41683 42504961
Breath sounds abnormal 12.33 11.09 3 74688 12090 42534554
Infantile back arching 12.23 11.09 5 74686 89 42546555
Dysgeusia 12.22 11.09 26 74665 34163 42512481
Jaundice neonatal 12.21 11.09 17 74674 2162 42544482
Multiple sclerosis 12.14 11.09 35 74656 7563 42539081
Intentional dose omission 12.12 11.09 39 74652 8947 42537697
Dyspnoea exertional 12.12 11.09 46 74645 50102 42496542
Myocardial infarction 12.11 11.09 149 74542 123860 42422784
Shock 12.10 11.09 90 74601 29031 42517613
Physical assault 12.04 11.09 12 74679 1070 42545574
Panic reaction 12.02 11.09 15 74676 1715 42544929
Drug screen positive 12.01 11.09 24 74667 4107 42542537
Pulmonary congestion 11.98 11.09 57 74634 15673 42530971
Akinesia 11.97 11.09 18 74673 2454 42544190
Arthropathy 11.89 11.09 21 74670 29576 42517068
Testis cancer 11.85 11.09 14 74677 1512 42545132
Heart rate abnormal 11.85 11.09 17 74674 2222 42544422
Coordination abnormal 11.84 11.09 36 74655 8014 42538630
Water intoxication 11.82 11.09 8 74683 412 42546232
Dehydration 11.80 11.09 176 74515 141591 42405053
Bacteraemia 11.74 11.09 16 74675 25024 42521620
Feeling drunk 11.74 11.09 17 74674 2241 42544403
Posture abnormal 11.70 11.09 18 74673 2503 42544141
Negative symptoms in schizophrenia 11.70 11.09 5 74686 100 42546544
Cognitive disorder 11.69 11.09 101 74590 34071 42512573
Urobilinogen urine 11.66 11.09 3 74688 10 42546634
Urine phosphorus decreased 11.61 11.09 4 74687 43 42546601
Economic problem 11.58 11.09 15 74676 1780 42544864
Mixed delusion 11.53 11.09 4 74687 44 42546600
Hormone-dependent prostate cancer 11.45 11.09 4 74687 45 42546599
Skin cancer 11.38 11.09 3 74688 11459 42535185
Haemorrhage 11.36 11.09 61 74630 60502 42486142
Rapid eye movement sleep behaviour disorder 11.33 11.09 7 74684 308 42546336
Tongue injury 11.31 11.09 6 74685 197 42546447
Heart rate decreased 11.29 11.09 30 74661 36502 42510142
Atrial septal defect 11.26 11.09 35 74656 7884 42538760
Diverticulitis 11.25 11.09 14 74677 22759 42523885
Bradyphrenia 11.23 11.09 27 74664 5235 42541409
Klebsiella infection 11.19 11.09 3 74688 11329 42535315

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3251.95 9.96 3037 200421 239344 110146497
Serotonin syndrome 2322.54 9.96 1413 202045 57740 110328101
Intentional overdose 2237.55 9.96 1893 201565 130608 110255233
Toxicity to various agents 2190.52 9.96 3481 199977 477074 109908767
Suicidal ideation 1468.91 9.96 1285 202173 92652 110293189
Drug interaction 1381.93 9.96 2920 200538 497263 109888578
Suicide attempt 1315.30 9.96 1260 202198 102134 110283707
Drug abuse 986.87 9.96 1413 202045 175998 110209843
Intentional self-injury 847.55 9.96 636 202822 36793 110349048
Electrocardiogram QT prolonged 778.75 9.96 981 202477 107979 110277862
Overdose 558.78 9.96 1290 202168 232504 110153337
Tremor 478.90 9.96 1112 202346 201120 110184721
Agitation 475.80 9.96 792 202666 112259 110273582
Cardio-respiratory arrest 442.04 9.96 777 202681 115059 110270782
Respiratory arrest 411.72 9.96 522 202936 57777 110328064
Synovitis 407.75 9.96 24 203434 274068 110111773
Poisoning 398.99 9.96 370 203088 28735 110357106
Hand deformity 375.45 9.96 5 203453 218501 110167340
Anxiety 362.73 9.96 1424 202034 343654 110042187
Systemic lupus erythematosus 355.98 9.96 30 203428 254308 110131533
Cardiac arrest 346.07 9.96 967 202491 195786 110190055
Infusion related reaction 341.33 9.96 137 203321 381025 110004816
Akathisia 339.69 9.96 269 203189 16844 110368997
Drug withdrawal syndrome 329.65 9.96 378 203080 37676 110348165
Somnolence 316.99 9.96 1233 202225 296216 110089625
Irritability 313.96 9.96 413 203045 47396 110338445
Pericarditis 308.96 9.96 25 203433 219089 110166752
Joint swelling 302.36 9.96 224 203234 442621 109943220
Febrile neutropenia 289.92 9.96 110 203348 316657 110069184
Coma 289.71 9.96 658 202800 117211 110268630
Helicobacter infection 286.30 9.96 11 203447 181866 110203975
Duodenal ulcer perforation 269.06 9.96 14 203444 177686 110208155
Aggression 268.23 9.96 429 203029 58781 110327060
Wound 267.54 9.96 53 203405 234384 110151457
Contraindicated product administered 257.71 9.96 69 203389 248198 110137643
Generalised tonic-clonic seizure 255.72 9.96 402 203056 54278 110331563
Folliculitis 254.49 9.96 13 203445 167640 110218201
Obsessive-compulsive disorder 246.14 9.96 158 203300 7083 110378758
Poisoning deliberate 245.88 9.96 272 203186 26059 110359782
Depression 244.29 9.96 1193 202265 316142 110069699
Seizure 243.81 9.96 927 202531 220258 110165583
Torsade de pointes 241.95 9.96 251 203207 22349 110363492
Glossodynia 241.47 9.96 56 203402 221948 110163893
Withdrawal syndrome 240.81 9.96 293 203165 31087 110354754
Reversible cerebral vasoconstriction syndrome 234.87 9.96 132 203326 4629 110381212
Respiratory depression 233.00 9.96 291 203167 31710 110354131
General physical health deterioration 230.11 9.96 266 203192 425029 109960812
Arthropathy 229.89 9.96 121 203337 287401 110098440
Depressed mood 229.41 9.96 406 203052 60403 110325438
Hepatic enzyme increased 221.93 9.96 160 203298 320732 110065109
Rheumatoid factor positive 221.91 9.96 4 203454 131636 110254205
Swelling 217.81 9.96 195 203263 350846 110034995
Muscle injury 216.66 9.96 10 203448 140797 110245044
Suicidal behaviour 214.44 9.96 112 203346 3385 110382456
Mydriasis 210.55 9.96 231 203227 21926 110363915
Mania 210.21 9.96 224 203234 20572 110365269
Impaired healing 207.33 9.96 53 203405 196664 110189177
Stomatitis 206.96 9.96 120 203338 270122 110115719
Rheumatoid arthritis 203.80 9.96 152 203306 299461 110086380
Drug dependence 203.10 9.96 345 203113 49675 110336166
Antidepressant drug level increased 199.35 9.96 65 203393 551 110385290
C-reactive protein abnormal 197.01 9.96 10 203448 129685 110256156
Treatment failure 194.62 9.96 136 203322 277098 110108743
Disturbance in attention 193.97 9.96 382 203076 61613 110324228
Extrapyramidal disorder 193.59 9.96 252 203206 28615 110357226
Alopecia 188.90 9.96 236 203222 364517 110021324
Tardive dyskinesia 182.95 9.96 171 203287 13408 110372433
Pneumonia 181.59 9.96 913 202545 875801 109510040
Infection 178.67 9.96 243 203215 361957 110023884
Electrocardiogram QRS complex prolonged 177.41 9.96 165 203293 12856 110372985
Lower respiratory tract infection 174.98 9.96 116 203342 242990 110142851
Peripheral swelling 173.43 9.96 298 203160 403736 109982105
Rash 173.39 9.96 849 202609 820115 109565726
Blister 167.04 9.96 106 203352 227270 110158571
Homicide 165.68 9.96 66 203392 1040 110384801
Antipsychotic drug level increased 164.99 9.96 122 203336 6893 110378948
Mobility decreased 164.61 9.96 118 203340 237304 110148537
Sleep disorder due to general medical condition, insomnia type 164.18 9.96 7 203451 105636 110280205
Facet joint syndrome 162.96 9.96 3 203455 96825 110289016
Panic attack 162.80 9.96 232 203226 28708 110357133
Sopor 161.69 9.96 262 203196 36284 110349557
Muscle twitching 161.12 9.96 235 203223 29700 110356141
Pyrexia 156.92 9.96 989 202469 897276 109488565
Hyperreflexia 156.64 9.96 134 203324 9351 110376490
Joint range of motion decreased 155.91 9.96 20 203438 121812 110264029
Sedation 155.85 9.96 375 203083 69308 110316533
Depressed level of consciousness 154.12 9.96 506 202952 111772 110274069
C-reactive protein increased 154.12 9.96 106 203352 217813 110168028
Therapeutic product effect decreased 153.55 9.96 134 203324 244182 110141659
Euphoric mood 152.54 9.96 128 203330 8699 110377142
Lip dry 151.12 9.96 8 203450 100075 110285766
Bursitis 151.09 9.96 28 203430 129890 110255951
Abdominal discomfort 150.13 9.96 312 203146 393546 109992295
Intentional product misuse 147.16 9.96 558 202900 132346 110253495
Hallucination, auditory 141.74 9.96 207 203251 26190 110359651
Dystonia 140.95 9.96 204 203254 25601 110360240
Ill-defined disorder 140.89 9.96 56 203402 156797 110229044
Irritable bowel syndrome 140.49 9.96 63 203395 164152 110221689
Psoriatic arthropathy 140.08 9.96 95 203363 196666 110189175
Bezoar 139.13 9.96 89 203369 3965 110381876
Abnormal behaviour 138.74 9.96 254 203204 38785 110347056
Myelosuppression 135.09 9.96 10 203448 94330 110291511
Dissociation 134.64 9.96 125 203333 9717 110376124
Paranoia 134.24 9.96 185 203273 22189 110363652
Nasopharyngitis 131.25 9.96 336 203122 394025 109991816
Myoclonus 130.53 9.96 225 203233 32773 110353068
Nightmare 129.54 9.96 246 203212 38617 110347224
Anaemia 128.32 9.96 544 202914 546542 109839299
Thrombocytopenia 128.25 9.96 282 203176 348603 110037238
Drug intolerance 128.00 9.96 356 203102 406156 109979685
Fibromyalgia 126.44 9.96 79 203379 170830 110215011
Disinhibition 125.77 9.96 76 203382 3058 110382783
Arthralgia 125.68 9.96 879 202579 778753 109607088
Intentional product use issue 125.58 9.96 163 203295 247743 110138098
Gastrointestinal disorder 124.72 9.96 157 203301 241795 110144046
Inflammation 123.83 9.96 104 203354 193134 110192707
Restless legs syndrome 123.46 9.96 187 203271 24439 110361402
Disease progression 123.06 9.96 161 203297 243873 110141968
Dyskinesia 122.80 9.96 284 203174 51162 110334679
Malignant neoplasm progression 121.98 9.96 86 203372 174481 110211360
Tachycardia 119.57 9.96 770 202688 225875 110159966
Sinus bradycardia 117.89 9.96 202 203256 29281 110356560
Hyperhidrosis 117.70 9.96 666 202792 186632 110199209
Anger 116.81 9.96 159 203299 18848 110366993
Restlessness 115.48 9.96 293 203165 55966 110329875
Discomfort 115.24 9.96 135 203323 214572 110171269
Crying 115.10 9.96 185 203273 25443 110360398
Clonus 114.05 9.96 108 203350 8608 110377233
Grip strength decreased 113.38 9.96 9 203449 80165 110305676
Swollen tongue 111.27 9.96 302 203156 60060 110325781
Tic 110.83 9.96 73 203385 3420 110382421
Suspected suicide 110.29 9.96 138 203320 15061 110370780
Muscle rigidity 110.02 9.96 175 203283 23856 110361985
Type 2 diabetes mellitus 109.19 9.96 99 203359 177133 110208708
Galactorrhoea 106.21 9.96 76 203382 4079 110381762
Pancytopenia 103.93 9.96 140 203318 209473 110176368
Wound infection 103.53 9.96 25 203433 96440 110289401
Parkinsonism 99.42 9.96 160 203298 22027 110363814
Neutropenia 98.97 9.96 355 203103 374265 110011576
Psychotic disorder 98.08 9.96 259 203199 50678 110335163
Increased appetite 96.17 9.96 128 203330 14849 110370992
Platelet count decreased 96.05 9.96 173 203285 230270 110155571
Rhabdomyolysis 95.61 9.96 457 203001 119944 110265897
Coma scale abnormal 95.19 9.96 103 203355 9623 110376218
Priapism 95.15 9.96 82 203376 5779 110380062
Self-injurious ideation 94.25 9.96 72 203386 4274 110381567
Off label use 93.94 9.96 2076 201382 1498109 108887732
Musculoskeletal pain 93.02 9.96 120 203338 182903 110202938
Abnormal dreams 92.68 9.96 116 203342 12664 110373177
Liver disorder 91.81 9.96 76 203382 142167 110243674
Drug hypersensitivity 91.42 9.96 477 202981 453613 109932228
Mood swings 90.82 9.96 156 203302 22656 110363185
Neuroleptic malignant syndrome 90.22 9.96 196 203262 33863 110351978
Blood lactic acid decreased 87.77 9.96 35 203423 553 110385288
Osteoarthritis 87.50 9.96 125 203333 182498 110203343
Mental disorder 86.99 9.96 209 203249 38582 110347259
Metabolic acidosis 86.88 9.96 389 203069 99355 110286486
Peripheral venous disease 86.07 9.96 24 203434 84093 110301748
Impulsive behaviour 85.58 9.96 61 203397 3254 110382587
Antipsychotic drug level below therapeutic 85.30 9.96 48 203410 1687 110384154
Miosis 83.18 9.96 147 203311 21836 110364005
Product substitution issue 83.15 9.96 151 203307 22910 110362931
Hostility 82.29 9.96 55 203403 2641 110383200
Sinus tachycardia 81.40 9.96 222 203236 44271 110341570
Complication of device insertion 80.27 9.96 90 203368 8748 110377093
Musculoskeletal stiffness 80.13 9.96 256 203202 279566 110106275
Pain 79.64 9.96 1257 202201 953698 109432143
Bradypnoea 78.43 9.96 88 203370 8561 110377280
Swelling face 78.12 9.96 357 203101 91964 110293877
Hallucination 76.94 9.96 380 203078 101052 110284789
Unresponsive to stimuli 76.59 9.96 275 203183 63515 110322326
Cardiac output increased 76.29 9.96 32 203426 579 110385262
Wheezing 76.27 9.96 229 203229 255001 110130840
Drug level increased 75.54 9.96 226 203232 47493 110338348
Drug abuser 74.57 9.96 69 203389 5340 110380501
Mucosal inflammation 74.53 9.96 42 203416 96099 110289742
Feeling abnormal 74.27 9.96 578 202880 180133 110205708
Tearfulness 73.58 9.96 79 203379 7316 110378525
Lung disorder 73.38 9.96 137 203321 179910 110205931
Catatonia 73.21 9.96 97 203361 11203 110374638
Oedema 72.84 9.96 175 203283 209801 110176040
Mood altered 72.10 9.96 136 203322 21239 110364602
Victim of child abuse 72.02 9.96 38 203420 1173 110384668
Emotional distress 69.67 9.96 211 203247 44636 110341205
Cytomegalovirus infection 69.50 9.96 9 203449 54435 110331406
Red blood cell sedimentation rate increased 68.61 9.96 29 203429 78273 110307568
Major depression 68.55 9.96 91 203367 10530 110375311
Libido increased 68.51 9.96 48 203410 2491 110383350
Cytokine release syndrome 68.40 9.96 22 203436 70284 110315557
Nail disorder 68.40 9.96 12 203446 57923 110327918
Sinusitis 68.24 9.96 297 203161 296391 110089450
Stress cardiomyopathy 68.13 9.96 112 203346 15694 110370147
Inappropriate antidiuretic hormone secretion 68.12 9.96 175 203283 33676 110352165
Therapeutic product effect variable 67.84 9.96 49 203409 2669 110383172
Epidural lipomatosis 67.54 9.96 44 203414 2023 110383818
Oculogyric crisis 67.11 9.96 56 203402 3776 110382065
Product complaint 67.08 9.96 104 203354 13868 110371973
Cholecystitis chronic 66.94 9.96 85 203373 9415 110376426
Penile abscess 66.47 9.96 20 203438 126 110385715
Vitamin B1 decreased 66.07 9.96 33 203425 906 110384935
Homicidal ideation 65.59 9.96 54 203404 3573 110382268
Social avoidant behaviour 65.48 9.96 64 203394 5305 110380536
Accidental death 65.41 9.96 62 203396 4947 110380894
Dysphonia 65.28 9.96 295 203163 75634 110310207
Diarrhoea 64.94 9.96 1599 201859 1137906 109247935
Obsessive-compulsive symptom 64.93 9.96 24 203434 305 110385536
Speech disorder 64.44 9.96 254 203204 61315 110324526
Liver function test increased 64.01 9.96 42 203416 88506 110297335
Renal impairment 63.83 9.96 159 203299 188286 110197555
Multiple sclerosis 63.68 9.96 144 203314 25554 110360287
Arthritis 63.57 9.96 133 203325 167453 110218388
Psychomotor hyperactivity 63.47 9.96 125 203333 20152 110365689
Bradyphrenia 63.01 9.96 92 203366 11636 110374205
Liver injury 62.58 9.96 113 203345 150300 110235541
Sepsis 62.44 9.96 350 203108 326996 110058845
Live birth 62.06 9.96 25 203433 69459 110316382
Hypercholesterolaemia 61.81 9.96 46 203412 90791 110295050
Hyperprolactinaemia 61.51 9.96 68 203390 6507 110379334
Product use issue 61.24 9.96 330 203128 311365 110074476
Blood prolactin increased 59.75 9.96 57 203401 4585 110381256
Nervousness 59.72 9.96 176 203282 36675 110349166
Apathy 59.40 9.96 107 203351 16132 110369709
Adjustment disorder with depressed mood 59.15 9.96 6 203452 43877 110341964
Loss of consciousness 58.43 9.96 585 202873 195721 110190120
Poor quality sleep 58.42 9.96 147 203311 27930 110357911
Lethargy 58.25 9.96 332 203126 93244 110292597
Coeliac disease 57.97 9.96 6 203452 43181 110342660
Autoimmune disorder 57.78 9.96 24 203434 65459 110320382
Taste disorder 57.63 9.96 24 203434 65363 110320478
Choreoathetosis 57.58 9.96 37 203421 1661 110384180
Fear 57.52 9.96 130 203328 23063 110362778
Sulphaemoglobinaemia 57.46 9.96 26 203432 569 110385272
Prescribed underdose 57.32 9.96 24 203434 65150 110320691
Acute respiratory distress syndrome 56.10 9.96 220 203238 52978 110332863
Child abuse 56.02 9.96 29 203429 860 110384981
Atrial fibrillation 55.82 9.96 225 203233 229417 110156424
Hypersensitivity 55.77 9.96 475 202983 403523 109982318
Blepharospasm 55.46 9.96 16 203442 54835 110331006
Asphyxia 55.00 9.96 96 203362 14119 110371722
Pulmonary fibrosis 54.90 9.96 64 203394 101978 110283863
Dependence 54.37 9.96 43 203415 2686 110383155
Hypotension 54.31 9.96 1304 202154 522545 109863296
Hypertonia 54.22 9.96 72 203386 8334 110377507
Cardiac failure 53.45 9.96 172 203286 187454 110198387
Thinking abnormal 53.15 9.96 98 203360 15042 110370799
Bradycardia 52.50 9.96 476 202982 155041 110230800
Bipolar I disorder 52.11 9.96 39 203419 2244 110383597
Decorticate posture 52.03 9.96 21 203437 343 110385498
Septic shock 51.74 9.96 135 203323 157393 110228448
Lower limb fracture 51.47 9.96 38 203420 75310 110310531
Libido decreased 51.46 9.96 59 203399 5876 110379965
Bipolar disorder 50.35 9.96 72 203386 8935 110376906
Soft tissue injury 50 9.96 38 203420 2238 110383603
Neuropathy peripheral 49.92 9.96 166 203292 179111 110206730
Hyponatraemia 49.43 9.96 615 202843 217038 110168803
Myocardial depression 49.38 9.96 25 203433 707 110385134
Dyspnoea 49.29 9.96 1607 201851 1105265 109280576
Bruxism 49.07 9.96 53 203405 4941 110380900
Long QT syndrome 49.07 9.96 63 203395 7055 110378786
Anorgasmia 48.85 9.96 33 203425 1613 110384228
Alcoholism 48.63 9.96 46 203412 3661 110382180
Night sweats 48.60 9.96 109 203349 133874 110251967
Dermatitis atopic 48.28 9.96 129 203329 25412 110360429
Hepatic function abnormal 48.04 9.96 56 203402 89239 110296602
Maternal exposure during pregnancy 47.79 9.96 274 203184 254609 110131232
Blood creatinine increased 47.79 9.96 174 203284 182715 110203126
Hyperlactacidaemia 47.44 9.96 67 203391 8219 110377622
Loss of libido 47.18 9.96 42 203416 3091 110382750
Dysarthria 46.92 9.96 290 203168 83831 110302010
Binge eating 46.88 9.96 23 203435 607 110385234
Disorientation 46.82 9.96 255 203203 70416 110315425
Hip arthroplasty 46.81 9.96 22 203436 55791 110330050
Physical assault 46.80 9.96 32 203426 1596 110384245
Cerebral vasoconstriction 46.73 9.96 31 203427 1470 110384371
Heart sounds 46.59 9.96 28 203430 1115 110384726
Attention deficit hyperactivity disorder 46.49 9.96 49 203409 4442 110381399
Affective disorder 46.23 9.96 78 203380 11163 110374678
Therapeutic product effect incomplete 46.16 9.96 233 203225 223572 110162269
Vasoplegia syndrome 45.37 9.96 53 203405 5386 110380455
Derealisation 45.15 9.96 35 203423 2123 110383718
Mental status changes 44.73 9.96 266 203192 75856 110309985
Mental impairment 44.48 9.96 116 203342 22523 110363318
Respiration abnormal 44.31 9.96 71 203387 9738 110376103
Morbid thoughts 44.04 9.96 25 203433 894 110384947
Emotional disorder 43.95 9.96 94 203364 16066 110369775
Hypomania 43.54 9.96 72 203386 10138 110375703
Sciatica 43.50 9.96 64 203394 92335 110293506
Feeling guilty 43.36 9.96 25 203433 921 110384920
Sternal fracture 43.22 9.96 41 203417 3275 110382566
Multiple sclerosis relapse 43.03 9.96 195 203263 50045 110335796
Vitamin B1 increased 42.53 9.96 15 203443 165 110385676
Parasomnia 42.50 9.96 23 203435 748 110385093
Drug-induced liver injury 42.48 9.96 99 203359 119968 110265873
Insomnia 42.45 9.96 914 202544 359676 110026165
Synaesthesia 42.40 9.96 8 203450 0 110385841
Erythema 42.32 9.96 338 203120 291109 110094732
Neoplasm progression 42.31 9.96 34 203424 64561 110321280
Herpes zoster 41.95 9.96 85 203373 108294 110277547
Blood cholesterol increased 41.85 9.96 186 203272 184599 110201242
Respiratory disorder 41.47 9.96 42 203416 71340 110314501
Blood hyposmosis 41.41 9.96 10 203448 22 110385819
Atrioventricular block first degree 41.31 9.96 85 203373 14140 110371701
Treatment noncompliance 40.95 9.96 252 203206 72738 110313103
Hypersomnia 40.78 9.96 129 203329 27932 110357909
Urinary retention 40.62 9.96 243 203215 69440 110316401
Persistent genital arousal disorder 39.60 9.96 21 203437 655 110385186
Juvenile idiopathic arthritis 39.59 9.96 52 203406 5955 110379886
Negative thoughts 39.55 9.96 29 203429 1617 110384224
Alcohol interaction 39.49 9.96 41 203417 3653 110382188
Thrombotic microangiopathy 39.25 9.96 4 203454 29145 110356696
Salivary hypersecretion 39.20 9.96 94 203364 17327 110368514
Foetal exposure during pregnancy 39.06 9.96 58 203400 7447 110378394
Delusion 39.02 9.96 114 203344 23641 110362200
Compulsive sexual behaviour 38.79 9.96 16 203442 277 110385564
Prolonged expiration 38.78 9.96 28 203430 1524 110384317
Influenza like illness 38.67 9.96 287 203171 88125 110297716
Drug screen positive 38.45 9.96 53 203405 6357 110379484
Asthma 38.34 9.96 286 203172 250005 110135836
Vision blurred 38.14 9.96 384 203074 128638 110257203
Panic reaction 38.10 9.96 48 203410 5274 110380567
Onychomycosis 37.58 9.96 12 203446 38519 110347322
Schizoaffective disorder 37.53 9.96 37 203421 3099 110382742
Post-traumatic neck syndrome 37.52 9.96 34 203424 2561 110383280
Sexual dysfunction 37.52 9.96 61 203397 8469 110377372
Borderline personality disorder 37.14 9.96 24 203434 1088 110384753
Gait inability 36.79 9.96 128 203330 136248 110249593
Urticaria 36.69 9.96 392 203066 318465 110067376
Anhedonia 36.62 9.96 85 203373 15343 110370498
Yawning 36.59 9.96 27 203431 1520 110384321
Acute kidney injury 36.51 9.96 890 202568 634540 109751301
Marital problem 36.46 9.96 14 203444 199 110385642
Abnormal sleep-related event 36.43 9.96 22 203436 884 110384957
Oedema peripheral 36.25 9.96 408 203050 328252 110057589
Brugada syndrome 35.96 9.96 27 203431 1561 110384280
Cogwheel rigidity 35.91 9.96 39 203419 3659 110382182
Carbon monoxide poisoning 35.83 9.96 16 203442 339 110385502
Knee arthroplasty 35.73 9.96 40 203418 64908 110320933
Pleural effusion 35.52 9.96 187 203271 177522 110208319
Somnambulism 35.51 9.96 51 203407 6354 110379487
Eye movement disorder 35.45 9.96 64 203394 9664 110376177
Pulseless electrical activity 35.14 9.96 88 203370 16669 110369172
Social anxiety disorder 35.13 9.96 22 203436 944 110384897
Huntington's disease 35.09 9.96 8 203450 12 110385829
Autonomic nervous system imbalance 34.98 9.96 48 203410 5732 110380109
Blood lactate dehydrogenase increased 34.89 9.96 19 203439 44315 110341526
Finger deformity 34.68 9.96 9 203449 33083 110352758
Staring 34.39 9.96 34 203424 2858 110382983
Tachyphrenia 34.33 9.96 31 203427 2325 110383516
Enuresis 34.31 9.96 40 203418 4056 110381785
Bulimia nervosa 34.16 9.96 15 203443 305 110385536
Hallucination, visual 34.13 9.96 154 203304 39451 110346390
Colitis ulcerative 34.11 9.96 56 203402 77307 110308534
Depressive symptom 34.10 9.96 58 203400 8356 110377485
Bone marrow failure 33.64 9.96 34 203424 57814 110328027
Rubber sensitivity 33.63 9.96 31 203427 2387 110383454
Obsessive thoughts 33.62 9.96 24 203434 1283 110384558
Concussion 33.57 9.96 69 203389 11469 110374372
Tension 33.53 9.96 44 203414 5034 110380807
Mucosal prolapse syndrome 33.34 9.96 7 203451 5 110385836
Aspergillus infection 33.27 9.96 4 203454 25612 110360229
Tumour lysis syndrome 33.01 9.96 8 203450 30793 110355048
Neutrophil count decreased 32.97 9.96 113 203345 120828 110265013
Flat affect 32.70 9.96 31 203427 2474 110383367
Urinary incontinence 32.65 9.96 176 203282 48411 110337430
Alcohol use 32.45 9.96 39 203419 4083 110381758
Alcohol poisoning 32.44 9.96 59 203399 8961 110376880
Traumatic coma 31.85 9.96 10 203448 74 110385767
Decreased interest 31.59 9.96 42 203416 4866 110380975
Hallucinations, mixed 31.44 9.96 57 203401 8636 110377205
Therapeutic response unexpected 31.40 9.96 106 203352 23737 110362104
Drug ineffective for unapproved indication 30.84 9.96 307 203151 102531 110283310
Device placement issue 30.68 9.96 26 203432 1791 110384050
Breath sounds abnormal 30.57 9.96 5 203453 25399 110360442
Tubulointerstitial nephritis 30.34 9.96 33 203425 54251 110331590
Violence-related symptom 30.32 9.96 20 203438 939 110384902
Ventricular hypokinesia 30.23 9.96 65 203393 11149 110374692
Protein C increased 29.87 9.96 9 203449 57 110385784
Dysphemia 29.84 9.96 37 203421 4000 110381841
Distributive shock 29.83 9.96 45 203413 5859 110379982
Prostate cancer 29.82 9.96 16 203442 37625 110348216
Bone marrow oedema syndrome 29.61 9.96 9 203449 59 110385782
Breast cancer stage II 29.56 9.96 7 203451 27368 110358473
Reduced facial expression 29.49 9.96 35 203423 3616 110382225
Basilar migraine 29.48 9.96 9 203449 60 110385781
Polyneuropathy 29.44 9.96 11 203447 32001 110353840
Jaundice neonatal 29.35 9.96 12 203446 203 110385638
Blunted affect 29.29 9.96 16 203442 530 110385311
Angioedema 29.03 9.96 293 203165 98207 110287634
Blood pressure fluctuation 28.69 9.96 59 203399 74765 110311076
Depersonalisation/derealisation disorder 28.49 9.96 27 203431 2154 110383687
Self esteem decreased 28.22 9.96 20 203438 1057 110384784
Pupil fixed 28.09 9.96 35 203423 3803 110382038
Fall 28.00 9.96 1368 202090 602114 109783727
Maternal exposure timing unspecified 27.99 9.96 3 203455 21010 110364831
Cystostomy 27.53 9.96 9 203449 77 110385764
Haemoglobin decreased 27.32 9.96 309 203149 248418 110137423
Cholecystectomy 27.26 9.96 61 203397 10748 110375093
Compulsive shopping 27.20 9.96 18 203440 850 110384991
Confusional state 27.16 9.96 1087 202371 467593 109918248
Exposure via ingestion 27.14 9.96 39 203419 4861 110380980
Transplant rejection 27.09 9.96 6 203452 24561 110361280
Ideas of reference 26.96 9.96 11 203447 185 110385656
Bacteraemia 26.91 9.96 23 203435 42367 110343474
Adverse event 26.81 9.96 106 203352 108703 110277138
White blood cell count decreased 26.79 9.96 281 203177 229109 110156732
Breast discomfort 26.71 9.96 15 203443 525 110385316
Stress 26.68 9.96 304 203154 105044 110280797
Self-medication 26.64 9.96 44 203414 6188 110379653
Hypoalbuminaemia 26.58 9.96 10 203448 28964 110356877
Gambling disorder 26.50 9.96 26 203432 2165 110383676
Feeling drunk 26.49 9.96 41 203417 5459 110380382
Blood uric acid increased 26.44 9.96 4 203454 21525 110364316
Visceral congestion 26.38 9.96 21 203437 1324 110384517
Sleep-related eating disorder 26.16 9.96 18 203440 907 110384934
Panic disorder 26.03 9.96 32 203426 3429 110382412
Burning mouth syndrome 26.01 9.96 16 203442 665 110385176
Middle insomnia 25.99 9.96 90 203368 20412 110365429
Frequent bowel movements 25.95 9.96 58 203400 71332 110314509
Foetal arrhythmia 25.87 9.96 8 203450 56 110385785
Analgesic drug level increased 25.76 9.96 34 203424 3912 110381929
Haematotoxicity 25.70 9.96 4 203454 21078 110364763
Formication 25.67 9.96 41 203417 5607 110380234
Appetite disorder 25.62 9.96 56 203402 9713 110376128
Posture abnormal 25.58 9.96 36 203422 4402 110381439
Cerebral microinfarction 25.57 9.96 6 203452 11 110385830
Psychomotor retardation 25.56 9.96 49 203409 7743 110378098
Initial insomnia 25.50 9.96 58 203400 10331 110375510
Drug ineffective 25.31 9.96 2432 201026 1518108 108867733
Electrocardiogram repolarisation abnormality 25.11 9.96 26 203432 2309 110383532
Cough 25.03 9.96 652 202806 460989 109924852
Balance disorder 25.02 9.96 326 203132 116234 110269607
Blood potassium decreased 25 9.96 178 203280 53936 110331905
Non-cardiogenic pulmonary oedema 24.85 9.96 24 203434 1960 110383881
Dyslipidaemia 24.69 9.96 75 203383 15890 110369951
Colitis microscopic 24.66 9.96 67 203391 13327 110372514
Pain in extremity 24.59 9.96 695 202763 486423 109899418
Hepatic steatosis 24.56 9.96 164 203294 48667 110337174
Decreased appetite 24.51 9.96 677 202781 475169 109910672
Ascites 24.43 9.96 88 203370 92720 110293121
Product administration interrupted 24.42 9.96 60 203398 11232 110374609
Asthenia 24.36 9.96 1028 202430 687971 109697870
Dysphoria 24.34 9.96 43 203415 6385 110379456
Diet failure 24.30 9.96 7 203451 37 110385804
Blood pressure measurement 24.28 9.96 14 203444 516 110385325
Blood bilirubin increased 24.26 9.96 66 203392 75906 110309935
Substance-induced psychotic disorder 24.14 9.96 39 203419 5385 110380456
Hyperthermia 24.09 9.96 90 203368 21182 110364659
Serum serotonin decreased 24.03 9.96 6 203452 16 110385825
Serum sickness-like reaction 23.87 9.96 16 203442 772 110385069
COVID-19 pneumonia 23.77 9.96 20 203438 37123 110348718
Colitis 23.76 9.96 102 203356 102221 110283620
Feeling of despair 23.68 9.96 32 203426 3766 110382075
Accidental overdose 23.66 9.96 170 203288 51664 110334177
Device expulsion 23.61 9.96 116 203342 30775 110355066
Menstruation irregular 23.54 9.96 40 203418 5757 110380084
Vaginal haemorrhage 23.51 9.96 100 203358 24974 110360867
Foot deformity 23.39 9.96 33 203425 48447 110337394
Trichotillomania 23.34 9.96 10 203448 191 110385650
Pseudomonas infection 23.32 9.96 11 203447 27842 110357999
Personality change 23.30 9.96 58 203400 10944 110374897
Genital anaesthesia 23.27 9.96 6 203452 19 110385822
Gallbladder disorder 23.01 9.96 88 203370 20941 110364900
Oral discharge 22.97 9.96 11 203447 275 110385566
Dry mouth 22.91 9.96 246 203212 199702 110186139
Sluggishness 22.90 9.96 46 203412 7521 110378320
Drug tolerance decreased 22.87 9.96 11 203447 27529 110358312
Adverse reaction 22.83 9.96 13 203445 29581 110356260
Developmental delay 22.78 9.96 20 203438 1445 110384396
Pruritus 22.64 9.96 858 202600 580702 109805139
Fluid retention 22.52 9.96 93 203365 94214 110291627
Eosinophilic pneumonia acute 22.49 9.96 21 203437 1644 110384197
Bladder dilatation 22.43 9.96 25 203433 2414 110383427
Nystagmus 22.42 9.96 59 203399 11518 110374323
Infusion site reaction 22.38 9.96 3 203455 17679 110368162
Headache 22.37 9.96 1899 201559 880478 109505363
Dizziness 22.24 9.96 1530 201928 696663 109689178
Enterocolitis 22.20 9.96 4 203454 18945 110366896
End stage renal disease 22.20 9.96 6 203452 21467 110364374
Cytopenia 22.15 9.96 14 203444 30102 110355739
Postural orthostatic tachycardia syndrome 22.14 9.96 22 203436 1860 110383981
Anterograde amnesia 22.14 9.96 16 203442 872 110384969
Blood pressure diastolic decreased 22.14 9.96 20 203438 35865 110349976
Device material issue 22.11 9.96 13 203445 497 110385344
Ulcer haemorrhage 22.07 9.96 7 203451 22564 110363277
Graft versus host disease 21.97 9.96 4 203454 18802 110367039
Induced abortion failed 21.91 9.96 9 203449 154 110385687
Altered state of consciousness 21.85 9.96 181 203277 57445 110328396
Dreamy state 21.82 9.96 7 203451 56 110385785
Bronchopulmonary aspergillosis 21.80 9.96 14 203444 29849 110355992
Palmar-plantar erythrodysaesthesia syndrome 21.77 9.96 26 203432 40999 110344842
Heavy menstrual bleeding 21.77 9.96 73 203385 16292 110369549
Loss of personal independence in daily activities 21.75 9.96 174 203284 149846 110235995
Single umbilical artery 21.74 9.96 5 203453 8 110385833
Pneumocystis jirovecii pneumonia 21.72 9.96 28 203430 42707 110343134
Hypersexuality 21.58 9.96 22 203436 1918 110383923
Ataxia 21.56 9.96 111 203347 29997 110355844
Exostosis 21.46 9.96 32 203426 45924 110339917
Phobia 21.40 9.96 12 203446 419 110385422
Hyperkalaemia 21.34 9.96 154 203304 135642 110250199
Blood magnesium decreased 21.33 9.96 83 203375 19913 110365928
Rectal haemorrhage 21.29 9.96 131 203327 119702 110266139
Haematochezia 21.21 9.96 125 203333 115399 110270442
Agitation neonatal 21.20 9.96 4 203454 0 110385841
Dermatillomania 21.19 9.96 11 203447 328 110385513
Back injury 21.19 9.96 34 203424 47365 110338476
Echolalia 21.18 9.96 13 203445 538 110385303
Ventricular arrhythmia 21.18 9.96 53 203405 10034 110375807
Drooling 21.13 9.96 43 203415 7096 110378745
Abdominal pain upper 21.12 9.96 485 202973 348626 110037215
Joint stiffness 21.04 9.96 59 203399 67184 110318657
Disseminated intravascular coagulation 21.04 9.96 27 203431 41259 110344582
Amenorrhoea 20.98 9.96 50 203408 9181 110376660
Full blood count abnormal 20.81 9.96 45 203413 56007 110329834
Vertigo 20.81 9.96 248 203210 86622 110299219
Heart rate decreased 20.78 9.96 80 203378 82676 110303165
Feeling jittery 20.77 9.96 67 203391 14655 110371186
Cardiomegaly 20.58 9.96 107 203351 29023 110356818
Serum ferritin abnormal 20.45 9.96 12 203446 457 110385384
CYP3A4 polymorphism 20.44 9.96 7 203451 70 110385771
Self-destructive behaviour 20.40 9.96 15 203443 840 110385001
Breast enlargement 20.35 9.96 20 203438 1669 110384172
Cholinergic syndrome 20.34 9.96 18 203440 1314 110384527
Cataplexy 20.30 9.96 17 203441 1152 110384689
Hyperphosphataemia 20.22 9.96 3 203455 16378 110369463
Ectopic pregnancy 20.20 9.96 23 203435 2274 110383567
Blood phosphorus increased 20.15 9.96 3 203455 16337 110369504
Oxygen saturation decreased 20.12 9.96 188 203270 156794 110229047
Drug use disorder 20.08 9.96 76 203382 17998 110367843
Blood test abnormal 20.02 9.96 14 203444 28540 110357301
Energy increased 20.00 9.96 29 203429 3645 110382196
Logorrhoea 19.86 9.96 34 203424 4923 110380918
Antidepressant therapy 19.85 9.96 5 203453 14 110385827
Chorea 19.78 9.96 27 203431 3208 110382633
Haemodynamic instability 19.72 9.96 89 203369 22799 110363042
Disability 19.68 9.96 16 203442 30207 110355634
Myelodysplastic syndrome 19.64 9.96 24 203434 37460 110348381
Narcolepsy 19.50 9.96 19 203439 1569 110384272
Communication disorder 19.46 9.96 34 203424 5005 110380836
Lupus-like syndrome 19.45 9.96 28 203430 40764 110345077
Pituitary tumour benign 19.31 9.96 25 203433 2822 110383019
Hyporesponsive to stimuli 19.22 9.96 25 203433 2835 110383006
Retrograde ejaculation 19.21 9.96 11 203447 400 110385441
Drug eruption 19.17 9.96 44 203414 53615 110332226
Accommodation disorder 19.16 9.96 13 203445 640 110385201
Blood pressure systolic increased 19.11 9.96 83 203375 82908 110302933
Blood pressure systolic abnormal 19.05 9.96 11 203447 24839 110361002
IIIrd nerve paresis 18.90 9.96 9 203449 222 110385619
Salpingo-oophorectomy bilateral 18.88 9.96 10 203448 311 110385530
Medical observation 18.83 9.96 9 203449 224 110385617
Thought insertion 18.71 9.96 6 203452 48 110385793
Supraventricular tachyarrhythmia 18.67 9.96 8 203450 153 110385688
Foreign body in reproductive tract 18.66 9.96 15 203443 959 110384882
Prescription drug used without a prescription 18.57 9.96 35 203423 5461 110380380
Posterior reversible encephalopathy syndrome 18.47 9.96 21 203437 33840 110352001
Prolonged rupture of membranes 18.39 9.96 6 203452 51 110385790
Incubator therapy 18.39 9.96 6 203452 51 110385790
Bundle branch block right 18.32 9.96 57 203401 12234 110373607
Cytomegalovirus viraemia 18.30 9.96 5 203453 17759 110368082
Pyramidal tract syndrome 18.30 9.96 14 203444 833 110385008
Chronic actinic dermatitis 18.30 9.96 5 203453 21 110385820
Resting tremor 18.20 9.96 19 203439 1704 110384137
Angle closure glaucoma 18.15 9.96 27 203431 3472 110382369
Pulmonary haemosiderosis 18.11 9.96 5 203453 22 110385819
Food allergy 18.10 9.96 7 203451 19941 110365900
Agoraphobia 18.08 9.96 13 203445 703 110385138
Coordination abnormal 18.06 9.96 93 203365 25135 110360706
Liver function test abnormal 17.93 9.96 200 203258 68750 110317091
Psychiatric symptom 17.89 9.96 47 203411 9166 110376675
Gestational diabetes 17.86 9.96 41 203417 7348 110378493
Haemophagocytic lymphohistiocytosis 17.84 9.96 19 203439 31540 110354301
Abortion spontaneous 17.76 9.96 116 203342 34166 110351675
Immune effector cell-associated neurotoxicity syndrome 17.58 9.96 3 203455 14779 110371062
Laboratory test abnormal 17.55 9.96 34 203424 44045 110341796
Laryngitis 17.51 9.96 32 203426 42379 110343462
Osteonecrosis of jaw 17.46 9.96 39 203419 47978 110337863
Patent ductus arteriosus 17.43 9.96 8 203450 181 110385660
Dehydroepiandrosterone decreased 17.43 9.96 5 203453 26 110385815
Erectile dysfunction 17.39 9.96 74 203384 18482 110367359
Acute myeloid leukaemia 17.35 9.96 27 203431 38083 110347758
Systolic dysfunction 17.32 9.96 30 203428 4385 110381456
Diffuse large B-cell lymphoma 17.29 9.96 4 203454 15894 110369947
Hospitalisation 17.27 9.96 173 203285 142320 110243521
Osteoporosis 17.24 9.96 92 203366 87060 110298781
Dysuria 17.19 9.96 178 203280 60053 110325788
Meningorrhagia 17.14 9.96 10 203448 377 110385464
Basal cell carcinoma 17.10 9.96 36 203422 45234 110340607
Menopausal symptoms 17.03 9.96 22 203436 2479 110383362
Gastric bypass 16.97 9.96 17 203441 1452 110384389
Foetal monitoring abnormal 16.93 9.96 8 203450 194 110385647
Ventricular hypertrophy 16.93 9.96 39 203419 7006 110378835
Heart rate 16.88 9.96 9 203449 284 110385557
Neutropenic sepsis 16.84 9.96 19 203439 30727 110355114
Contusion 16.82 9.96 315 203143 233046 110152795
Hypothermia 16.81 9.96 94 203364 26208 110359633
Pulmonary alveolar haemorrhage 16.81 9.96 8 203450 20142 110365699
Confabulation 16.80 9.96 11 203447 510 110385331
Panniculitis 16.79 9.96 4 203454 15578 110370263
Purple glove syndrome 16.76 9.96 9 203449 288 110385553
Product use in unapproved indication 16.75 9.96 663 202795 446714 109939127
Anticholinergic syndrome 16.68 9.96 29 203429 4251 110381590
Heart disease congenital 16.67 9.96 12 203446 650 110385191
Depression suicidal 16.65 9.96 31 203427 4793 110381048
Acute myopia 16.63 9.96 8 203450 202 110385639
Agranulocytosis 16.63 9.96 58 203400 61702 110324139
Electrocardiogram QT shortened 16.62 9.96 9 203449 293 110385548
Syncope 16.57 9.96 489 202969 202047 110183794
Alcohol withdrawal syndrome 16.52 9.96 20 203438 2110 110383731
Trismus 16.39 9.96 37 203421 6559 110379282
Procedural pneumothorax 16.37 9.96 7 203451 133 110385708
Anorexia nervosa 16.37 9.96 9 203449 302 110385539
Female genital tract fistula 16.37 9.96 5 203453 16514 110369327
Electrocardiogram abnormal 16.31 9.96 73 203385 18636 110367205
Dyspepsia 16.29 9.96 250 203208 190715 110195126
Autism spectrum disorder 16.28 9.96 19 203439 1929 110383912
Venoocclusive liver disease 16.20 9.96 4 203454 15203 110370638
Plasma cell mastitis 16.17 9.96 5 203453 35 110385806
Stereotypy 16.05 9.96 14 203444 1003 110384838
Substance use disorder 16.04 9.96 39 203419 7251 110378590
Hypoxic-ischaemic encephalopathy 16.04 9.96 44 203414 8803 110377038
Premature labour 16.02 9.96 45 203413 9127 110376714
Tenosynovitis 16.01 9.96 5 203453 16278 110369563
Tourette's disorder 15.97 9.96 6 203452 80 110385761
Slow response to stimuli 15.96 9.96 19 203439 1969 110383872
Oesophageal food impaction 15.96 9.96 11 203447 556 110385285
Nodule 15.95 9.96 22 203436 32609 110353232
Sudden onset of sleep 15.95 9.96 12 203446 696 110385145
Hypoplastic left heart syndrome 15.93 9.96 4 203454 11 110385830
Muscular weakness 15.93 9.96 342 203116 248126 110137715
Peritonitis 15.92 9.96 22 203436 32585 110353256
Sleep attacks 15.91 9.96 8 203450 223 110385618
Legal problem 15.87 9.96 7 203451 144 110385697
Antisocial behaviour 15.86 9.96 13 203445 855 110384986
Respiratory symptom 15.79 9.96 4 203454 14941 110370900
Oral candidiasis 15.75 9.96 37 203421 44723 110341118
Lactic acidosis 15.70 9.96 249 203209 92562 110293279
Gout 15.63 9.96 27 203431 36539 110349302
Blood triglycerides increased 15.62 9.96 86 203372 23840 110362001
Maternal drugs affecting foetus 15.61 9.96 17 203441 1600 110384241
Bladder cancer 15.53 9.96 9 203449 20283 110365558
Drug withdrawal syndrome neonatal 15.50 9.96 9 203449 336 110385505
Therapy change 15.49 9.96 47 203411 9950 110375891
Anaphylactic reaction 15.47 9.96 135 203323 114165 110271676
Hepatic cirrhosis 15.34 9.96 68 203390 67558 110318283
Second primary malignancy 15.34 9.96 7 203451 18061 110367780
Hypercalcaemia 15.30 9.96 40 203418 46617 110339224
Premature baby 15.28 9.96 30 203428 4825 110381016
Metastases to lung 15.28 9.96 12 203446 23051 110362790
Coma uraemic 15.27 9.96 5 203453 43 110385798
Selective mutism 15.27 9.96 6 203452 91 110385750
Proctitis 15.26 9.96 6 203452 16921 110368920
Sleep paralysis 15.22 9.96 13 203445 905 110384936
Appendicitis 15.15 9.96 18 203440 28446 110357395
Atrioventricular block second degree 15.14 9.96 41 203417 8140 110377701
Cataract 15.13 9.96 85 203373 79400 110306441
Pregnancy on oral contraceptive 15.10 9.96 13 203445 915 110384926
Complication of device removal 15.09 9.96 29 203429 4591 110381250
Lumbar radiculopathy 14.99 9.96 21 203437 2557 110383284
Spinal shock 14.97 9.96 5 203453 46 110385795
Proteinuria 14.97 9.96 32 203426 39986 110345855
Metastases to central nervous system 14.95 9.96 12 203446 22805 110363036
Multiple system atrophy 14.94 9.96 9 203449 360 110385481
Creatinine renal clearance decreased 14.90 9.96 11 203447 21804 110364037
Gastrointestinal hypermotility 14.85 9.96 9 203449 364 110385477
Economic problem 14.83 9.96 27 203431 4104 110381737
Large intestine perforation 14.82 9.96 6 203452 16623 110369218
Locked-in syndrome 14.81 9.96 13 203445 939 110384902
Pathogen resistance 14.76 9.96 7 203451 17665 110368176
Mutism 14.70 9.96 23 203435 3090 110382751
Theft 14.70 9.96 8 203450 263 110385578
Pre-eclampsia 14.68 9.96 42 203416 8608 110377233
Joint hyperextension 14.67 9.96 9 203449 372 110385469
Hypoaesthesia 14.67 9.96 453 203005 313770 110072071
Hypnopompic hallucination 14.65 9.96 6 203452 102 110385739
Blood creatine phosphokinase MB 14.60 9.96 4 203454 17 110385824
Pupillary disorder 14.59 9.96 11 203447 640 110385201
Feeling of body temperature change 14.59 9.96 34 203424 6154 110379687
Alkalosis 14.57 9.96 12 203446 794 110385047
Pneumonia aspiration 14.53 9.96 220 203238 81013 110304828
Respiratory tract infection 14.51 9.96 75 203383 71542 110314299
Pre-existing condition improved 14.46 9.96 35 203423 6491 110379350
Cold agglutinins positive 14.43 9.96 5 203453 52 110385789
Cerebral infarction 14.42 9.96 48 203410 51790 110334051
Thrombosis 14.41 9.96 129 203329 108533 110277308
Atrial septal defect 14.40 9.96 19 203439 2186 110383655
Cholangitis 14.39 9.96 6 203452 16329 110369512
Anal incontinence 14.37 9.96 79 203379 21885 110363956
Talipes 14.36 9.96 7 203451 182 110385659
Intentional dose omission 14.35 9.96 74 203384 20006 110365835
Medication overuse headache 14.34 9.96 16 203442 1547 110384294
Electrocardiogram QT interval 14.33 9.96 8 203450 277 110385564
Personality disorder 14.28 9.96 54 203404 12783 110373058
Sleep apnoea syndrome 14.26 9.96 125 203333 40322 110345519
Retinal phototoxicity 14.24 9.96 4 203454 19 110385822
Post-traumatic stress disorder 14.21 9.96 35 203423 6561 110379280
Disturbance in sexual arousal 14.15 9.96 9 203449 397 110385444
Heart rate abnormal 14.13 9.96 37 203421 7201 110378640
Oesophageal achalasia 14.03 9.96 13 203445 1008 110384833
Post 5-alpha-reductase inhibitor syndrome 13.94 9.96 6 203452 116 110385725
Differential white blood cell count abnormal 13.87 9.96 19 203439 2265 110383576
Dissociative identity disorder 13.86 9.96 5 203453 59 110385782
Alcohol problem 13.86 9.96 5 203453 59 110385782
Renal artery thrombosis 13.84 9.96 10 203448 545 110385296
Gross motor delay 13.82 9.96 7 203451 198 110385643
Potentiating drug interaction 13.81 9.96 50 203408 11593 110374248
Malignant catatonia 13.80 9.96 11 203447 695 110385146
Alcohol abuse 13.78 9.96 29 203429 4900 110380941
Weight increased 13.76 9.96 922 202536 418722 109967119
Inhibitory drug interaction 13.71 9.96 29 203429 4918 110380923
Polyarthritis 13.70 9.96 9 203449 18954 110366887
Essential tremor 13.69 9.96 17 203441 1841 110384000
Breast pain 13.65 9.96 45 203413 9955 110375886
Eosinophilic pneumonia chronic 13.65 9.96 10 203448 557 110385284
Umbilical cord around neck 13.60 9.96 4 203454 23 110385818
Metastases to bone 13.56 9.96 23 203435 31349 110354492
Acute psychosis 13.55 9.96 29 203429 4958 110380883
Parkinsonian gait 13.49 9.96 13 203445 1059 110384782
Grandiosity 13.46 9.96 10 203448 569 110385272
Arrhythmia 13.46 9.96 191 203267 69384 110316457
Macular degeneration 13.45 9.96 12 203446 21647 110364194
High density lipoprotein increased 13.41 9.96 15 203443 1454 110384387
Pulmonary toxicity 13.40 9.96 8 203450 17738 110368103
Peripheral sensory neuropathy 13.34 9.96 7 203451 16673 110369168
Coagulation factor VII level decreased 13.33 9.96 7 203451 214 110385627
Compulsive hoarding 13.29 9.96 5 203453 67 110385774
Myasthenia gravis 13.26 9.96 12 203446 21499 110364342
Blood lactic acid increased 13.24 9.96 61 203397 15760 110370081
Brain death 13.24 9.96 34 203424 6539 110379302
Walking aid user 13.19 9.96 16 203442 25059 110360782
Antisocial personality disorder 13.15 9.96 5 203453 69 110385772
Antidepressant drug level above therapeutic 13.13 9.96 11 203447 746 110385095
Biliary dyskinesia 13.02 9.96 19 203439 2402 110383439
Febrile bone marrow aplasia 13.01 9.96 8 203450 17457 110368384
Spontaneous haematoma 12.96 9.96 17 203441 1944 110383897
Impulse-control disorder 12.95 9.96 18 203440 2176 110383665
Antipsychotic drug level above therapeutic 12.90 9.96 19 203439 2421 110383420
Blood parathyroid hormone decreased 12.90 9.96 4 203454 13085 110372756
Oesophageal dilatation 12.89 9.96 10 203448 607 110385234
Memory impairment 12.87 9.96 463 202995 196481 110189360
Death of relative 12.86 9.96 8 203450 339 110385502
Hyperacusis 12.83 9.96 21 203437 2931 110382910
Procedural hypertension 12.82 9.96 8 203450 341 110385500
Hypoprolactinaemia 12.81 9.96 4 203454 29 110385812
Biliary colic 12.80 9.96 27 203431 4570 110381271
Skin toxicity 12.75 9.96 3 203455 11780 110374061
Polydipsia 12.73 9.96 37 203421 7651 110378190
Intervertebral disc displacement 12.71 9.96 9 203449 475 110385366
Placenta praevia 12.66 9.96 11 203447 784 110385057
Squamous cell carcinoma of skin 12.65 9.96 8 203450 17195 110368646
Diverticulitis 12.64 9.96 53 203405 53469 110332372
Tremor neonatal 12.62 9.96 3 203455 6 110385835
Right aortic arch 12.62 9.96 3 203455 6 110385835
Acquired cardiac septal defect 12.62 9.96 3 203455 6 110385835
Psychopathic personality 12.62 9.96 3 203455 6 110385835
Apgar score low 12.62 9.96 3 203455 6 110385835
Portal tract inflammation 12.60 9.96 7 203451 240 110385601
Injection site mass 12.58 9.96 83 203375 24530 110361311
Nephrosclerosis 12.56 9.96 17 203441 2004 110383837
Pneumonia bacterial 12.54 9.96 18 203440 26243 110359598
Duodenal ulcer repair 12.54 9.96 5 203453 79 110385762
Klebsiella infection 12.53 9.96 11 203447 19998 110365843
Ventricular tachycardia 12.52 9.96 144 203314 49865 110335976
Bradykinesia 12.52 9.96 46 203412 10742 110375099
Foetal alcohol syndrome 12.47 9.96 4 203454 32 110385809
Tinnitus 12.44 9.96 168 203290 60372 110325469
Gastrointestinal haemorrhage 12.37 9.96 222 203236 165296 110220545
Neonatal seizure 12.36 9.96 4 203454 33 110385808
Vasculitis 12.35 9.96 30 203428 35843 110349998
Blood creatine phosphokinase increased 12.34 9.96 196 203262 72881 110312960
Optic ischaemic neuropathy 12.30 9.96 25 203433 4122 110381719
Right ventricular hypertension 12.30 9.96 3 203455 7 110385834
Muscle contractions involuntary 12.26 9.96 26 203432 4418 110381423
Chronic sinusitis 12.17 9.96 17 203441 25067 110360774
Persecutory delusion 12.12 9.96 32 203426 6259 110379582
Prescription form tampering 12.12 9.96 9 203449 512 110385329
Skin necrosis 12.11 9.96 13 203445 21499 110364342
Inadequate analgesia 12.08 9.96 28 203430 5049 110380792
Psychotic behaviour 12.08 9.96 14 203444 1411 110384430
Chronic fatigue syndrome 12.04 9.96 14 203444 1415 110384426
Spondylitis 12.04 9.96 3 203455 11335 110374506
Cyclothymic disorder 12.04 9.96 7 203451 262 110385579
Rabbit syndrome 12.03 9.96 8 203450 381 110385460
Blood urea increased 12.03 9.96 56 203402 54901 110330940
Appendicitis perforated 12.02 9.96 23 203435 3629 110382212
Drug titration error 12.02 9.96 15 203443 1632 110384209
Prostatic specific antigen increased 12.02 9.96 4 203454 12507 110373334
Amnesia 12 9.96 266 203192 105142 110280699
Pustular psoriasis 11.98 9.96 5 203453 13600 110372241
Low birth weight baby 11.97 9.96 11 203447 844 110384997
Constipation 11.96 9.96 537 202921 357249 110028592
Emotional poverty 11.95 9.96 12 203446 1028 110384813
Cerebrovascular stenosis 11.91 9.96 6 203452 168 110385673
Secondary hypogonadism 11.88 9.96 11 203447 852 110384989
Reflexes abnormal 11.88 9.96 12 203446 1035 110384806
Long QT syndrome congenital 11.87 9.96 6 203452 169 110385672
Fatigue 11.85 9.96 2012 201446 1213946 109171895
Multiple organ dysfunction syndrome 11.81 9.96 202 203256 151508 110234333
Amaurosis fugax 11.77 9.96 18 203440 2372 110383469
Food interaction 11.73 9.96 17 203441 2135 110383706
Orthostatic hypotension 11.69 9.96 179 203279 66070 110319771
Hypoperfusion 11.68 9.96 21 203437 3160 110382681
Pupillary reflex impaired 11.67 9.96 24 203434 3991 110381850
Pulmonary congestion 11.60 9.96 97 203361 30869 110354972
Jaw disorder 11.60 9.96 28 203430 5184 110380657
Epilepsy 11.59 9.96 123 203335 100086 110285755
Tongue biting 11.57 9.96 20 203438 2919 110382922
Loss of bladder sensation 11.55 9.96 5 203453 98 110385743
Uterine hypertonus 11.55 9.96 7 203451 283 110385558
Urinary tract disorder 11.54 9.96 30 203428 5814 110380027
Intrusive thoughts 11.53 9.96 10 203448 711 110385130
Hyperinsulinism 11.52 9.96 3 203455 10 110385831
Torticollis 11.50 9.96 21 203437 3200 110382641
Compulsions 11.47 9.96 8 203450 412 110385429
Joint dislocation 11.45 9.96 29 203429 34161 110351680
Benign prostatic hyperplasia 11.44 9.96 10 203448 18224 110367617
Hepatocellular injury 11.44 9.96 143 203315 50499 110335342
Nasal polyps 11.38 9.96 5 203453 13195 110372646
Joint effusion 11.36 9.96 13 203445 20892 110364949
Ventricular extrasystoles 11.36 9.96 76 203382 22565 110363276
Hypertonic bladder 11.28 9.96 28 203430 5274 110380567
Status migrainosus 11.24 9.96 5 203453 105 110385736
Hypophosphataemia 11.23 9.96 28 203430 33154 110352687
Chemical burn 11.21 9.96 10 203448 738 110385103
Clostridium difficile colitis 11.20 9.96 42 203416 43736 110342105
Product prescribing error 11.19 9.96 144 203314 51187 110334654
Metastases to liver 11.10 9.96 31 203427 35355 110350486
Hyperdynamic left ventricle 11.10 9.96 9 203449 583 110385258
Secondary tic 11.09 9.96 3 203455 12 110385829
Pregnancy with contraceptive patch 11.09 9.96 3 203455 12 110385829
Imprisonment 11.08 9.96 10 203448 749 110385092
Cold sweat 11.08 9.96 74 203384 21957 110363884
Electrocardiogram ST segment abnormal 11.07 9.96 15 203443 1770 110384071
Electrocardiogram T wave inversion 11.05 9.96 29 203429 5651 110380190
Muscle necrosis 10.99 9.96 15 203443 1782 110384059
Exposure via inhalation 10.98 9.96 5 203453 111 110385730
Epstein-Barr virus infection 10.91 9.96 11 203447 18727 110367114
Leukocytosis 10.91 9.96 149 203309 53679 110332162
Medical diet 10.90 9.96 3 203455 13 110385828
Melanocytic hyperplasia 10.90 9.96 3 203455 13 110385828
Vascular stenosis 10.87 9.96 10 203448 768 110385073
Blood glucose fluctuation 10.83 9.96 35 203423 7663 110378178
Road traffic accident 10.80 9.96 136 203322 107262 110278579
Nephrotic syndrome 10.78 9.96 6 203452 13825 110372016
Victim of crime 10.75 9.96 13 203445 1370 110384471
Hypoglycaemia neonatal 10.74 9.96 4 203454 52 110385789
Enterococcal infection 10.71 9.96 13 203445 20353 110365488
Gaze palsy 10.66 9.96 21 203437 3386 110382455
Pneumonia fungal 10.66 9.96 7 203451 14747 110371094
Hysterectomy 10.62 9.96 36 203422 8078 110377763
Snoring 10.61 9.96 32 203426 6752 110379089
Cervicobrachial syndrome 10.59 9.96 12 203446 1180 110384661
Lip swelling 10.57 9.96 141 203317 50526 110335315
Cardiotoxicity 10.57 9.96 60 203398 16821 110369020
Plasma cell myeloma 10.56 9.96 70 203388 62866 110322975
Alpha 2 globulin decreased 10.55 9.96 3 203455 15 110385826
Sex hormone binding globulin decreased 10.55 9.96 3 203455 15 110385826
Testicular microlithiasis 10.55 9.96 3 203455 15 110385826
Rapid eye movement sleep behaviour disorder 10.50 9.96 9 203449 630 110385211
Slow speech 10.48 9.96 21 203437 3427 110382414
Chromaturia 10.48 9.96 91 203367 29269 110356572
Vertebral artery dissection 10.46 9.96 6 203452 219 110385622
Leukaemia 10.41 9.96 34 203424 7484 110378357
Otosalpingitis 10.39 9.96 3 203455 16 110385825
Free androgen index decreased 10.39 9.96 3 203455 16 110385825
Androgen insensitivity syndrome 10.39 9.96 3 203455 16 110385825
Hypnagogic hallucination 10.36 9.96 6 203452 223 110385618
Muscle neoplasm 10.34 9.96 4 203454 58 110385783
Rash maculo-papular 10.34 9.96 87 203371 74135 110311706
Photophobia 10.34 9.96 82 203376 25689 110360152
Regurgitation 10.33 9.96 21 203437 3464 110382377
Inflammatory marker increased 10.27 9.96 7 203451 14462 110371379
Fear of crowded places 10.24 9.96 3 203455 17 110385824
Urobilinogen urine 10.24 9.96 3 203455 17 110385824
Hepatitis 10.23 9.96 111 203347 89943 110295898
Congenital central nervous system anomaly 10.23 9.96 5 203453 131 110385710
Hypokinesia 10.20 9.96 72 203386 21754 110364087
Blood pressure diastolic abnormal 10.20 9.96 20 203438 25795 110360046
Intermenstrual bleeding 10.19 9.96 32 203426 6902 110378939
Alpha 1 globulin increased 10.16 9.96 5 203453 133 110385708
Hypocalcaemic seizure 10.12 9.96 5 203453 134 110385707
Dissociative disorder 10.12 9.96 12 203446 1239 110384602
Fluid intake restriction 10.10 9.96 4 203454 62 110385779
Faeces soft 10.06 9.96 4 203454 11206 110374635
Decerebrate posture 10.03 9.96 6 203452 237 110385604
Extensor plantar response 10.02 9.96 15 203443 1940 110383901
Sleep talking 9.99 9.96 12 203446 1256 110384585
Gastrointestinal toxicity 9.97 9.96 4 203454 11144 110374697

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Feeling jittery 41.90 21.84 18 970 60 112905
Exposure during pregnancy 34.98 21.84 50 938 1303 111662
Hypertonia neonatal 25.03 21.84 23 965 360 112605
Tremor neonatal 22.99 21.84 14 974 111 112854

Pharmacologic Action:

SourceCodeDescription
ATC N06AB03 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
ATC N06CA03 NERVOUS SYSTEM
PSYCHOANALEPTICS
PSYCHOLEPTICS AND PSYCHOANALEPTICS IN COMBINATION
Antidepressants in combination with psycholeptics
FDA MoA N0000000109 Serotonin Uptake Inhibitors
MeSH PA D000928 Antidepressive Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D017367 Selective Serotonin Reuptake Inhibitors
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018490 Serotonin Agents
MeSH PA D018687 Antidepressive Agents, Second-Generation
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D065690 Cytochrome P-450 CYP2D6 Inhibitors
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:50949 serotonin uptake inhibitor
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:88188 drug allergen
FDA EPC N0000175696 Serotonin Reuptake Inhibitor

Related Drugs by ATC class:

N06AB Selective serotonin reuptake inhibitors 7 drugs
citalopramescitaloprametoperidonefluvoxamineparoxetinesertralinezimeldine
N06CA Antidepressants in combination with psycholeptics 2 drugs
amitriptylinemelitracen

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Premenstrual dysphoric disorder indication 596004
Depressive disorder indication 35489007
Bulimia nervosa indication 78004001
Bipolar affective disorder, current episode depression indication 191627008 DOID:3312
Obsessive-compulsive disorder indication 191736004 DOID:10933
Major depressive disorder indication 370143000
Panic disorder indication 371631005 DOID:594
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Postpartum depression off-label use 58703003 DOID:9478
Cataplexy and narcolepsy off-label use 193042000
Menopausal flushing off-label use 198436008
Fibromyalgia off-label use 203082005 DOID:631
Seasonal affective disorder off-label use 247803002
Suicidal thoughts contraindication 6471006
Weight gain finding contraindication 8943002
Sinus tachycardia contraindication 11092001
Hypercholesterolemia contraindication 13644009
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Cirrhosis of liver contraindication 19943007 DOID:5082
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Dehydration contraindication 34095006
Upper gastrointestinal hemorrhage contraindication 37372002
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Paralytic ileus contraindication 55525008 DOID:8442
Hyperlipidemia contraindication 55822004 DOID:1168
Anorexia nervosa contraindication 56882008 DOID:8689
Abnormal sexual function contraindication 56925008
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Heart failure contraindication 84114007 DOID:6000
Epilepsy contraindication 84757009 DOID:1826
Leukopenia contraindication 84828003 DOID:615
Hyponatremia contraindication 89627008
Tardive dyskinesia contraindication 102449007
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Cerebrovascular accident contraindication 230690007
Mania contraindication 231494001
Hypomania contraindication 231496004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Transient ischemic attack contraindication 266257000 DOID:224
Esophageal dysmotility contraindication 266434009 DOID:9192
Benign prostatic hyperplasia contraindication 266569009
Hypertriglyceridemia contraindication 302870006
Neutropenic disorder contraindication 303011007 DOID:1227
Serotonin syndrome contraindication 371089000
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Separation anxiety Indication

🐶 Veterinary products

ProductApplicantIngredients
Reconcile Pegasus Laboratories Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.32 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 9.09 WOMBAT-PK CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.36 WOMBAT-PK
Alpha-2A adrenergic receptor GPCR Ki 8.20 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 6.07 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.16 WOMBAT-PK
Sodium-dependent noradrenaline transporter Transporter Kd 6.62 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR Ki 6.61 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR ANTAGONIST Ki 5.30 IUPHAR
5-hydroxytryptamine receptor 2C GPCR Ki 6.40 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 6.11 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 5.70 PDSP
Alpha-2B adrenergic receptor GPCR Ki 6.16 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 5.70 WOMBAT-PK
Histamine H1 receptor GPCR Ki 5.96 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 6.05 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 5.57 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 6 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR Ki 5.54 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 5.57 PDSP
Sodium-dependent dopamine transporter Transporter Kd 5.44 WOMBAT-PK
Cytochrome P450 2D6 Enzyme IC50 6.16 DRUG MATRIX
Acetylcholinesterase Enzyme IC50 6.89 CHEMBL
Potassium channel subfamily K member 2 Ion channel IC50 4.85 CHEMBL
Histamine H3 receptor GPCR Ki 5.14 CHEMBL
Equilibrative nucleoside transporter 4 Transporter INHIBITOR Ki 4.64 IUPHAR
Transporter Transporter Ki 6.80 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 8.70 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 6.11 CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 6.50 IUPHAR
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.62 CHEMBL
Transporter Transporter Ki 6.84 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 7.97 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 7.07 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 6.96 CHEMBL
Serotonin 1 (5-HT1) receptor GPCR IC50 7.82 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 5.72 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 6.22 CHEMBL
Potassium voltage-gated channel subfamily C member 1 Ion channel IC50 4.88 CHEMBL
G protein-activated inward rectifier potassium channel 2 Ion channel GATING INHIBITOR IC50 4.80 IUPHAR
5-hydroxytryptamine receptor 6 GPCR ANTAGONIST Ki 5.80 IUPHAR
Sigma intracellular receptor 2 Membrane receptor Ki 4.79 CHEMBL

External reference:

IDSource
D00326 KEGG_DRUG
56296-78-7 SECONDARY_CAS_RN
4019389 VANDF
4019761 VANDF
C0016365 UMLSCUI
CHEBI:5118 CHEBI
RFX PDB_CHEM_ID
CHEMBL41 ChEMBL_ID
CHEMBL1201082 ChEMBL_ID
DB00472 DRUGBANK_ID
D005473 MESH_DESCRIPTOR_UI
3386 PUBCHEM_CID
203 IUPHAR_LIGAND_ID
3883 INN_ID
01K63SUP8D UNII
227224 RXNORM
17711 MMSL
28237 MMSL
37675 MMSL
4091 MMSL
41730 MMSL
4746 MMSL
d00236 MMSL
001514 NDDF
004613 NDDF
372767007 SNOMEDCT_US
53640004 SNOMEDCT_US
75115009 SNOMEDCT_US
01K63SUP8D INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5503 CAPSULE 25 mg ORAL ANDA 31 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5504 CAPSULE 25 mg ORAL ANDA 31 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5505 CAPSULE 50 mg ORAL ANDA 31 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5506 CAPSULE 25 mg ORAL ANDA 31 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5507 CAPSULE 50 mg ORAL ANDA 31 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7198 CAPSULE 40 mg ORAL ANDA 30 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7198 CAPSULE 40 mg ORAL ANDA 30 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0121-0721 SOLUTION 20 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0121-4721 SOLUTION 20 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-7625 CAPSULE 20 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8093 CAPSULE 10 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8183 CAPSULE 40 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8183 CAPSULE 40 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8612 CAPSULE 40 mg ORAL ANDA 32 sections
Prozac HUMAN PRESCRIPTION DRUG LABEL 1 0777-3104 CAPSULE 10 mg ORAL NDA 35 sections
Prozac HUMAN PRESCRIPTION DRUG LABEL 1 0777-3105 CAPSULE 20 mg ORAL NDA 35 sections
Prozac HUMAN PRESCRIPTION DRUG LABEL 1 0777-3107 CAPSULE 40 mg ORAL NDA 35 sections
Fluoxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0832-6032 FOR SOLUTION 20 mg ORAL ANDA 35 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7345 CAPSULE 10 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7346 CAPSULE 20 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 10544-065 CAPSULE 20 mg ORAL ANDA 33 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 10544-180 CAPSULE 10 mg ORAL ANDA 33 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 10544-181 CAPSULE 20 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 10544-582 CAPSULE 10 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 10544-583 CAPSULE 40 mg ORAL ANDA 33 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 13668-443 TABLET 10 mg ORAL ANDA 31 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 13668-473 TABLET 20 mg ORAL ANDA 31 sections
FLUOXETINE HUMAN PRESCRIPTION DRUG LABEL 1 16590-099 CAPSULE 10 mg ORAL ANDA 32 sections
FLUOXETINE HUMAN PRESCRIPTION DRUG LABEL 1 16590-100 CAPSULE 20 mg ORAL ANDA 33 sections
Prozac HUMAN PRESCRIPTION DRUG LABEL 1 16590-843 CAPSULE 20 mg ORAL NDA 13 sections