fluoxetine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives 1209 54910-89-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prozac
  • fluoxetine
  • fluoxetine hydrochloride
  • fluoxetin
  • fluoxetine HCl
The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
  • Molecular weight: 309.33
  • Formula: C17H18F3NO
  • CLOGP: 4.57
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 21.26
  • ALOGS: -5.26
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 15.20 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.25 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 4.30 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1987 FDA ELI LILLY AND CO

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1155.71 9.43 1703 127754 144217 46412388
Intentional overdose 717.28 9.43 892 128565 64052 46492553
Suicidal ideation 625.06 9.43 776 128681 55606 46500999
Toxicity to various agents 621.48 9.43 1626 127831 210140 46346465
Drug abuse 523.79 9.43 756 128701 62652 46493953
Serotonin syndrome 477.52 9.43 452 129005 23768 46532837
Depression 451.13 9.43 1259 128198 168845 46387760
Suicide attempt 409.64 9.43 625 128832 54411 46502194
Intentional self-injury 362.56 9.43 389 129068 23777 46532828
Drug interaction 287.94 9.43 1220 128237 201874 46354731
Anxiety 285.57 9.43 1128 128329 180829 46375776
Agitation 253.58 9.43 508 128949 54907 46501698
Electrocardiogram QT prolonged 221.18 9.43 459 128998 50866 46505739
Tremor 216.38 9.43 759 128698 114880 46441725
Rheumatoid arthritis 198.74 9.43 224 129233 239991 46316614
Overdose 190.44 9.43 669 128788 101310 46455295
Drug withdrawal syndrome 178.76 9.43 293 129164 27091 46529514
Cardio-respiratory arrest 171.09 9.43 456 129001 59413 46497192
Withdrawal syndrome 161.05 9.43 224 129233 17910 46538695
Poisoning 158.72 9.43 195 129262 13799 46542806
Drug intolerance 148.80 9.43 114 129343 146935 46409670
Respiratory arrest 145.15 9.43 302 129155 33514 46523091
Aggression 137.30 9.43 235 129222 22509 46534096
Irritability 129.53 9.43 263 129194 28683 46527922
Cardiac arrest 127.73 9.43 543 128914 89856 46466749
Akathisia 126.03 9.43 130 129327 7584 46549021
Treatment failure 122.97 9.43 52 129405 93035 46463570
Febrile neutropenia 120.07 9.43 56 129401 94571 46462034
Synovitis 111.10 9.43 18 129439 61057 46495548
Nightmare 108.86 9.43 178 129279 16420 46540185
Rash 104.30 9.43 572 128885 355940 46200665
Somnolence 104.18 9.43 767 128690 155754 46400851
Joint swelling 103.47 9.43 189 129268 165884 46390721
Torsade de pointes 103.26 9.43 147 129310 12007 46544598
Drug ineffective 103.11 9.43 1296 128161 676542 45880063
Mania 102.37 9.43 138 129319 10708 46545897
Disturbance in attention 101.09 9.43 251 129206 31309 46525296
Depressed mood 100.48 9.43 259 129198 33060 46523545
Suicidal behaviour 100.14 9.43 70 129387 2378 46554227
Dystonia 99.87 9.43 139 129318 11118 46545487
Systemic lupus erythematosus 98.77 9.43 29 129428 65151 46491454
Contraindicated product administered 97.34 9.43 50 129407 79897 46476708
Pneumonia 97.28 9.43 628 128829 375692 46180913
Product complaint 96.46 9.43 142 129315 11959 46544646
Neutropenia 95.57 9.43 156 129301 143048 46413557
Confusional state 90.64 9.43 755 128702 159137 46397468
Panic attack 89.47 9.43 183 129274 20059 46536546
Mydriasis 88.72 9.43 127 129330 10426 46546179
Foetal exposure during pregnancy 86.59 9.43 233 129224 30514 46526091
Crying 85.15 9.43 184 129273 20957 46535648
Product substitution issue 85.10 9.43 151 129306 14880 46541725
Sopor 83.81 9.43 176 129281 19652 46536953
Peripheral swelling 83.20 9.43 198 129259 157873 46398732
Exposure during pregnancy 81.75 9.43 547 128910 107665 46448940
Anaemia 78.25 9.43 404 129053 255375 46301230
Coma scale abnormal 77.55 9.43 82 129375 4924 46551681
Muscle rigidity 76.68 9.43 115 129342 9846 46546759
White blood cell count abnormal 74.11 9.43 81 129376 5051 46551554
Self-injurious ideation 72.05 9.43 56 129401 2244 46554361
Galactorrhoea 71.26 9.43 69 129388 3728 46552877
Mood swings 70.73 9.43 146 129311 16106 46540499
Hand deformity 70.58 9.43 7 129450 34567 46522038
Muscle twitching 70.06 9.43 137 129320 14535 46542070
Arthralgia 70.03 9.43 660 128797 363943 46192662
Infusion related reaction 69.62 9.43 108 129349 101100 46455505
Reversible cerebral vasoconstriction syndrome 67.68 9.43 48 129409 1669 46554936
Pyrexia 66.28 9.43 633 128824 348169 46208436
Anger 65.73 9.43 118 129339 11734 46544871
Obsessive-compulsive disorder 65.24 9.43 61 129396 3154 46553451
Infection 64.36 9.43 175 129282 133417 46423188
Hyperprolactinaemia 64.10 9.43 58 129399 2874 46553731
Bezoar 63.77 9.43 43 129414 1376 46555229
Alopecia 63.34 9.43 234 129223 162180 46394425
Tearfulness 62.75 9.43 67 129390 4068 46552537
Restlessness 62.62 9.43 184 129273 25340 46531265
Extrapyramidal disorder 62.25 9.43 112 129345 11156 46545449
Cough 62.07 9.43 379 129078 229870 46326735
Sedation 61.89 9.43 171 129286 22739 46533866
Insomnia 61.21 9.43 713 128744 164211 46392394
Pancytopenia 61.19 9.43 88 129369 84970 46471635
Atrial fibrillation 59.18 9.43 124 129333 103466 46453139
Acute kidney injury 58.59 9.43 398 129059 235457 46321148
Hallucination, auditory 58.26 9.43 106 129351 10650 46545955
Malignant neoplasm progression 57.54 9.43 57 129400 64869 46491736
Renal impairment 57.49 9.43 73 129384 74299 46482306
Parkinsonism 57.28 9.43 89 129368 7859 46548746
Diarrhoea 56.91 9.43 1153 128304 558449 45998156
Tic 56.85 9.43 38 129419 1198 46555407
Thrombocytopenia 55.73 9.43 173 129284 126408 46430197
Hypertonia neonatal 55.36 9.43 22 129435 221 46556384
Seizure 54.92 9.43 552 128905 122502 46434103
Abnormal behaviour 54.75 9.43 155 129302 20903 46535702
Tardive dyskinesia 53.72 9.43 84 129373 7459 46549146
Nasopharyngitis 53.63 9.43 232 129225 153766 46402839
Platelet count decreased 53.63 9.43 124 129333 99900 46456705
Therapeutic product effect incomplete 53.17 9.43 84 129373 78069 46478536
Coma 52.80 9.43 309 129148 58040 46498565
Mucosal inflammation 52.70 9.43 21 129436 38955 46517650
Depressed level of consciousness 52.55 9.43 266 129191 47303 46509302
Drug withdrawal syndrome neonatal 52.00 9.43 43 129414 1885 46554720
Off label use 51.37 9.43 743 128714 379098 46177507
Suspected suicide 51.32 9.43 64 129393 4597 46552008
Disease progression 50.72 9.43 111 129346 91189 46465416
Cerebral vasoconstriction 50.52 9.43 33 129424 1000 46555605
Atrial septal defect 50.02 9.43 74 129383 6258 46550347
Generalised tonic-clonic seizure 49.74 9.43 177 129280 26945 46529660
Accidental death 49.65 9.43 41 129416 1794 46554811
Maternal exposure during breast feeding 49.21 9.43 49 129408 2740 46553865
Cholecystitis chronic 48.87 9.43 97 129360 10402 46546203
Restless legs syndrome 48.63 9.43 124 129333 15719 46540886
Hyperhidrosis 48.58 9.43 418 129039 88890 46467715
Myocardial depression 48.32 9.43 25 129432 483 46556122
Hyperreflexia 48.29 9.43 66 129391 5188 46551417
Paranoia 48.24 9.43 97 129360 10500 46546105
Poisoning deliberate 47.96 9.43 82 129375 7844 46548761
Myoclonus 47.92 9.43 116 129341 14236 46542369
Mood altered 47.64 9.43 109 129348 12898 46543707
Emotional distress 46.89 9.43 189 129268 30518 46526087
Weight increased 46.29 9.43 676 128781 163797 46392808
Swelling 45.56 9.43 184 129273 124327 46432278
Abnormal dreams 44.32 9.43 92 129365 10187 46546418
Decorticate posture 43.97 9.43 21 129436 339 46556266
Cardiac failure 42.94 9.43 99 129358 79849 46476756
Dyspnoea 42.79 9.43 1096 128361 514452 46042153
Respiratory depression 42.25 9.43 97 129360 11503 46545102
Rheumatoid factor positive 42.14 9.43 4 129453 20457 46536148
Alcohol interaction 41.38 9.43 42 129415 2403 46554202
Product use issue 40.49 9.43 131 129326 94513 46462092
Bone marrow failure 40.09 9.43 16 129441 29653 46526952
Memory impairment 39.99 9.43 358 129099 76979 46479626
Blood creatinine increased 39.92 9.43 96 129361 76307 46480298
Wound 39.77 9.43 36 129421 42766 46513839
Cogwheel rigidity 39.70 9.43 33 129424 1457 46555148
Therapeutic response unexpected 39.67 9.43 114 129343 15502 46541103
Abdominal discomfort 39.56 9.43 251 129206 150914 46405691
Blood hyposmosis 39.02 9.43 10 129447 17 46556588
Glossodynia 38.12 9.43 40 129417 44333 46512272
Major depression 37.60 9.43 67 129390 6623 46549982
Stress cardiomyopathy 37.54 9.43 73 129384 7711 46548894
Amnesia 37.36 9.43 220 129237 41411 46515194
C-reactive protein increased 37.05 9.43 66 129391 58524 46498081
Anorgasmia 36.54 9.43 22 129435 576 46556029
Haemoglobin decreased 35.89 9.43 210 129247 128739 46427866
Dyskinesia 35.71 9.43 167 129290 28758 46527847
Clonus 35.62 9.43 50 129407 4030 46552575
Neuropathy peripheral 35.37 9.43 131 129326 90762 46465843
Impulsive behaviour 35.16 9.43 31 129426 1484 46555121
Arthropathy 35.01 9.43 119 129338 84581 46472024
Intentional product misuse 34.22 9.43 236 129221 46892 46509713
Cytomegalovirus infection 33.78 9.43 5 129452 18139 46538466
Hepatic enzyme increased 33.74 9.43 115 129342 81672 46474933
Apathy 33.65 9.43 67 129390 7201 46549404
Panic reaction 33.39 9.43 46 129411 3643 46552962
Herpes zoster 33.35 9.43 88 129369 67784 46488821
Traumatic coma 33.30 9.43 11 129446 61 46556544
Stomatitis 32.46 9.43 90 129367 68207 46488398
Dependence 32.37 9.43 33 129424 1898 46554707
Antipsychotic drug level increased 32.25 9.43 42 129415 3150 46553455
Erythema 32.04 9.43 248 129209 142572 46414033
Maternal drugs affecting foetus 31.96 9.43 56 129401 5462 46551143
General physical health deterioration 31.96 9.43 189 129268 115580 46441025
Drug dependence 31.59 9.43 124 129333 19777 46536828
Miosis 31.58 9.43 62 129395 6595 46550010
Libido increased 31.40 9.43 22 129435 750 46555855
Pleural effusion 31.34 9.43 121 129336 82831 46473774
Binge eating 31.33 9.43 17 129440 363 46556242
Dissociation 31.33 9.43 32 129425 1845 46554760
Electrocardiogram QRS complex prolonged 31.18 9.43 55 129402 5394 46551211
Talipes 31.09 9.43 28 129429 1379 46555226
Atrioventricular block first degree 31.05 9.43 59 129398 6127 46550478
Blood prolactin increased 30.85 9.43 40 129417 2987 46553618
Pericarditis 30.58 9.43 14 129443 23913 46532692
Physical assault 30.49 9.43 24 129433 980 46555625
Reduced facial expression 30.41 9.43 26 129431 1194 46555411
Blood pressure fluctuation 30.26 9.43 24 129433 30424 46526181
Affect lability 30.25 9.43 68 129389 7952 46548653
Oculogyric crisis 30.17 9.43 26 129431 1207 46555398
Loss of libido 30.11 9.43 27 129430 1322 46555283
White blood cell count decreased 30.05 9.43 185 129272 112046 46444559
Personality change 29.99 9.43 53 129404 5205 46551400
Hostility 29.89 9.43 27 129430 1335 46555270
Ventricular hypokinesia 29.86 9.43 46 129411 4032 46552573
Lower respiratory tract infection 29.75 9.43 68 129389 55021 46501584
Mental disorder 29.56 9.43 132 129325 22293 46534312
Hyperkalaemia 29.54 9.43 60 129397 50649 46505956
Blood lactate dehydrogenase increased 29.48 9.43 10 129447 20490 46536115
Agitation neonatal 29.37 9.43 18 129439 487 46556118
Ventricular fibrillation 29.28 9.43 84 129373 11412 46545193
Septic shock 28.49 9.43 75 129382 57818 46498787
Delusion of grandeur 28.46 9.43 12 129445 142 46556463
Abortion missed 28.44 9.43 28 129429 1544 46555061
Morbid thoughts 28.20 9.43 18 129439 524 46556081
Breech presentation 28.18 9.43 24 129433 1096 46555509
Disinhibition 28.14 9.43 22 129435 889 46555716
Hypersensitivity 27.95 9.43 274 129183 150047 46406558
Neoplasm progression 27.84 9.43 20 129437 26663 46529942
Therapeutic product effect decreased 27.79 9.43 126 129331 82475 46474130
Feeling abnormal 27.66 9.43 494 128963 124566 46432039
Sepsis 26.97 9.43 244 129213 135770 46420835
Catatonia 26.93 9.43 42 129415 3720 46552885
Atelectasis neonatal 26.92 9.43 6 129451 3 46556602
Fear 26.68 9.43 102 129355 16070 46540535
Peritonitis 26.66 9.43 12 129445 20702 46535903
Depressive symptom 26.63 9.43 36 129421 2800 46553805
Arthritis 26.57 9.43 117 129340 77199 46479406
Injury 26.56 9.43 211 129246 43816 46512789
Plasma cell myeloma 26.44 9.43 52 129405 44426 46512179
Persistent foetal circulation 26.25 9.43 13 129444 228 46556377
Bradyphrenia 25.97 9.43 55 129402 6175 46550430
Hypertonia 25.45 9.43 45 129412 4421 46552184
Constipation 25.44 9.43 335 129122 173762 46382843
Alcoholism 25.30 9.43 31 129426 2187 46554418
Unresponsive to stimuli 25.08 9.43 164 129293 32010 46524595
Pulseless electrical activity 25.08 9.43 59 129398 7108 46549497
Musculoskeletal pain 24.78 9.43 105 129352 70023 46486582
Migraine 24.72 9.43 300 129157 69726 46486879
Pulmonary valve stenosis 24.68 9.43 14 129443 327 46556278
Food interaction 24.64 9.43 17 129440 565 46556040
Lethargy 24.49 9.43 233 129224 50938 46505667
Leukopenia 24.35 9.43 102 129355 68241 46488364
Eating disorder symptom 24.18 9.43 11 129446 158 46556447
Drug hypersensitivity 24.16 9.43 504 128953 243321 46313284
Hallucination, visual 24.16 9.43 106 129351 17767 46538838
Psychotic disorder 23.93 9.43 125 129332 22496 46534109
Attention-seeking behaviour 23.62 9.43 9 129448 80 46556525
Marital problem 23.40 9.43 11 129446 171 46556434
Brugada syndrome 23.37 9.43 12 129445 228 46556377
Thinking abnormal 23.36 9.43 70 129387 9744 46546861
Dysarthria 23.33 9.43 181 129276 37317 46519288
Dysphoria 23.32 9.43 44 129413 4545 46552060
Intentional product use issue 23.30 9.43 72 129385 52708 46503897
Bulimia nervosa 23.27 9.43 16 129441 529 46556076
Fluid retention 22.99 9.43 69 129388 50977 46505628
Borderline personality disorder 22.76 9.43 18 129439 740 46555865
IIIrd nerve paresis 22.68 9.43 9 129448 90 46556515
Urinary incontinence 22.59 9.43 146 129311 28384 46528221
Inappropriate antidiuretic hormone secretion 22.49 9.43 88 129369 14014 46542591
Osteonecrosis of jaw 22.43 9.43 38 129419 34364 46522241
Nystagmus 22.26 9.43 49 129408 5650 46550955
Feeling of despair 21.85 9.43 26 129431 1779 46554826
Euphoric mood 21.75 9.43 41 129416 4231 46552374
Mental impairment 21.74 9.43 80 129377 12376 46544229
Psychomotor retardation 21.64 9.43 35 129422 3198 46553407
Speech disorder 21.64 9.43 173 129284 35994 46520611
Gallbladder disorder 21.58 9.43 101 129356 17397 46539208
Gastrointestinal haemorrhage 21.52 9.43 126 129331 77247 46479358
Pulmonary valve stenosis congenital 21.48 9.43 10 129447 152 46556453
Negative thoughts 21.42 9.43 18 129439 807 46555798
Diet failure 21.32 9.43 7 129450 38 46556567
Agoraphobia 21.23 9.43 13 129444 351 46556254
Myasthenic syndrome 21.19 9.43 11 129446 214 46556391
Self esteem decreased 21.01 9.43 15 129442 527 46556078
Neonatal asphyxia 20.96 9.43 11 129446 219 46556386
Patent ductus arteriosus 20.84 9.43 38 129419 3824 46552781
Hallucination 20.79 9.43 221 129236 49730 46506875
Posterior reversible encephalopathy syndrome 20.73 9.43 8 129449 15133 46541472
Hepatic function abnormal 20.67 9.43 40 129417 34381 46522224
Gestational diabetes 20.61 9.43 55 129402 7164 46549441
Road traffic accident 20.48 9.43 124 129333 23567 46533038
Balance disorder 20.47 9.43 271 129186 64250 46492355
Dissociative identity disorder 20.43 9.43 8 129449 77 46556528
Multiple sclerosis 20.33 9.43 128 129329 24663 46531942
Homicidal ideation 20.25 9.43 25 129432 1777 46554828
Drug use disorder 20.23 9.43 31 129426 2704 46553901
Neonatal hypoxia 20.22 9.43 14 129443 468 46556137
CYP3A4 polymorphism 20.16 9.43 8 129449 80 46556525
Depression suicidal 20.12 9.43 23 129434 1507 46555098
Mobility decreased 20.04 9.43 93 129364 60501 46496104
Pre-eclampsia 19.96 9.43 58 129399 7936 46548669
Burning mouth syndrome 19.87 9.43 13 129444 395 46556210
Trichotillomania 19.80 9.43 9 129448 129 46556476
Cataplexy 19.72 9.43 20 129437 1143 46555462
Flat affect 19.64 9.43 21 129436 1277 46555328
Psychomotor hyperactivity 19.60 9.43 65 129392 9548 46547057
Posterior segment of eye anomaly congenital 19.56 9.43 4 129453 0 46556605
Fear of weight gain 19.56 9.43 4 129453 0 46556605
Congenital multiplex arthrogryposis 19.56 9.43 4 129453 0 46556605
Posture abnormal 19.36 9.43 27 129430 2163 46554442
Duodenal ulcer repair 19.01 9.43 7 129450 56 46556549
Neonatal complications of substance abuse 18.99 9.43 5 129452 10 46556595
Drug abuser 18.97 9.43 33 129424 3200 46553405
Hyperthermia 18.92 9.43 57 129400 7957 46548648
Hyponatraemia 18.89 9.43 390 129067 100942 46455663
Coordination abnormal 18.84 9.43 70 129387 10879 46545726
Multiple sclerosis relapse 18.78 9.43 189 129268 41936 46514669
Intention tremor 18.72 9.43 12 129445 352 46556253
Primitive reflex test positive 18.67 9.43 5 129452 11 46556594
Emotional poverty 18.54 9.43 11 129446 280 46556325
Prolonged labour 18.54 9.43 14 129443 537 46556068
Inflammation 18.52 9.43 71 129386 48710 46507895
Differential white blood cell count abnormal 18.29 9.43 15 129442 650 46555955
Bipolar I disorder 18.27 9.43 22 129435 1524 46555081
Sleep paralysis 18.18 9.43 13 129444 458 46556147
Spinal shock 18.09 9.43 5 129452 13 46556592
Plasma cell mastitis 18.09 9.43 5 129452 13 46556592
Anterograde amnesia 18.07 9.43 12 129445 374 46556231
Palmar-plantar erythrodysaesthesia syndrome 18.06 9.43 18 129439 20433 46536172
Social avoidant behaviour 18.01 9.43 30 129427 2809 46553796
Progressive supranuclear palsy 18.01 9.43 7 129450 66 46556539
Electrolyte depletion 17.97 9.43 9 129448 162 46556443
Productive cough 17.88 9.43 76 129381 50639 46505966
Protein C increased 17.77 9.43 9 129448 166 46556439
Hospitalisation 17.74 9.43 103 129354 63282 46493323
Feeling guilty 17.65 9.43 13 129444 480 46556125
Long QT syndrome 17.51 9.43 31 129426 3049 46553556
Tachycardia 17.46 9.43 380 129077 99242 46457363
Small for dates baby 17.41 9.43 34 129423 3603 46553002
Eye movement disorder 17.37 9.43 40 129417 4753 46551852
pH body fluid increased 17.33 9.43 4 129453 3 46556602
Affective disorder 17.24 9.43 40 129417 4775 46551830
Hallucinations, mixed 17.24 9.43 35 129422 3814 46552791
Oppositional defiant disorder 17.23 9.43 6 129451 40 46556565
Breast enlargement 17.20 9.43 21 129436 1476 46555129
Procedural hypertension 17.18 9.43 11 129446 322 46556283
Gastric bypass 17.15 9.43 20 129437 1339 46555266
Tongue biting 17.09 9.43 20 129437 1344 46555261
Toxic epidermal necrolysis 17.07 9.43 22 129435 22256 46534349
Blood bilirubin increased 17.03 9.43 44 129413 34140 46522465
Liver function test increased 17.02 9.43 23 129434 22803 46533802
Feeling jittery 17.00 9.43 68 129389 10940 46545665
Drug screen positive 16.98 9.43 35 129422 3856 46552749
Nervousness 16.92 9.43 136 129321 28339 46528266
Blister 16.92 9.43 65 129392 44566 46512039
Blunted affect 16.89 9.43 9 129448 185 46556420
Heart rate 16.86 9.43 6 129451 43 46556562
Bruxism 16.68 9.43 30 129427 2987 46553618
Respiration abnormal 16.68 9.43 38 129419 4483 46552122
Induced abortion failed 16.67 9.43 10 129447 260 46556345
Disturbance in sexual arousal 16.66 9.43 7 129450 82 46556523
Sinus bradycardia 16.59 9.43 79 129378 13703 46542902
Withdrawal catatonia 16.52 9.43 6 129451 46 46556559
Dysphemia 16.43 9.43 26 129431 2332 46554273
Drug eruption 16.41 9.43 21 129436 21308 46535297
Congenital brain damage 16.33 9.43 4 129453 5 46556600
Infantile apnoea 16.28 9.43 15 129442 761 46555844
Drug level increased 16.25 9.43 97 129360 18344 46538261
Acute myeloid leukaemia 16.23 9.43 12 129445 15766 46540839
Joint range of motion decreased 16.22 9.43 11 129446 15113 46541492
Polyneuropathy 16.19 9.43 6 129451 11638 46544967
Pulmonary vasculitis 16.19 9.43 6 129451 49 46556556
Exposure via ingestion 16.10 9.43 32 129425 3435 46553170
Pulmonary haemosiderosis 16.08 9.43 5 129452 22 46556583
Accidental overdose 16.08 9.43 103 129354 19963 46536642
Placenta praevia 16.06 9.43 16 129441 895 46555710
Polydactyly 15.99 9.43 11 129446 364 46556241
Pericardial effusion 15.94 9.43 29 129428 25514 46531091
Intrusive thoughts 15.92 9.43 8 129449 145 46556460
Device related infection 15.89 9.43 21 129436 21020 46535585
Respiratory disorder neonatal 15.81 9.43 16 129441 912 46555693
Microcephaly 15.81 9.43 14 129443 674 46555931
Stress 15.72 9.43 215 129242 51336 46505269
Injection site pain 15.70 9.43 206 129251 106946 46449659
Prescribed overdose 15.70 9.43 64 129393 10385 46546220
Acute respiratory distress syndrome 15.45 9.43 109 129348 21813 46534792
Optic ischaemic neuropathy 15.32 9.43 16 129441 947 46555658
Alcohol withdrawal syndrome 15.31 9.43 15 129442 822 46555783
Agonal rhythm 15.25 9.43 5 129452 27 46556578
Atrioventricular block second degree 15.22 9.43 33 129424 3766 46552839
Thrombophlebitis superficial 15.19 9.43 39 129418 4964 46551641
Oxygen saturation decreased 15.07 9.43 121 129336 69043 46487562
Neuroleptic malignant syndrome 15.06 9.43 66 129391 11056 46545549
Asthenia 15.06 9.43 707 128750 310368 46246237
Dermatillomania 15.04 9.43 8 129449 164 46556441
Prolonged rupture of membranes 15.04 9.43 6 129451 61 46556544
Transplant rejection 15.03 9.43 4 129453 9592 46547013
Bradycardia neonatal 15.02 9.43 13 129444 607 46555998
Heart disease congenital 14.99 9.43 18 129439 1243 46555362
Product use in unapproved indication 14.96 9.43 169 129288 90104 46466501
Hypnopompic hallucination 14.95 9.43 5 129452 29 46556576
Impaired healing 14.92 9.43 52 129405 36691 46519914
Hip arthroplasty 14.81 9.43 17 129440 18095 46538510
Muscle enzyme increased 14.77 9.43 7 129450 111 46556494
Disorientation 14.74 9.43 162 129295 36756 46519849
Depersonalisation/derealisation disorder 14.69 9.43 16 129441 994 46555611
Dehydroepiandrosterone decreased 14.67 9.43 3 129454 0 46556605
Pregnancy with advanced maternal age 14.67 9.43 3 129454 0 46556605
Knee arthroplasty 14.65 9.43 27 129430 23638 46532967
Tachyphrenia 14.62 9.43 18 129439 1276 46555329
Gaze palsy 14.57 9.43 18 129439 1280 46555325
Sudden onset of sleep 14.54 9.43 13 129444 634 46555971
Narcolepsy 14.53 9.43 17 129440 1142 46555463
Tooth hypoplasia 14.46 9.43 6 129451 68 46556537
Cardiac failure congestive 14.34 9.43 174 129283 91576 46465029
Staring 14.32 9.43 19 129438 1451 46555154
Formication 14.32 9.43 33 129424 3923 46552682
Sinus tachycardia 14.31 9.43 106 129351 21543 46535062
Soft tissue injury 14.28 9.43 15 129442 894 46555711
Congenital musculoskeletal anomaly 14.26 9.43 11 129446 436 46556169
Substance abuse 14.25 9.43 34 129423 4133 46552472
Sleep disorder 14.20 9.43 195 129262 46600 46510005
Cleft palate 14.17 9.43 15 129442 902 46555703
Bipolar disorder 14.16 9.43 48 129409 7129 46549476
Infantile vomiting 14.15 9.43 6 129451 72 46556533
Ascites 14.05 9.43 53 129404 36531 46520074
Umbilical cord around neck 14.02 9.43 8 129449 189 46556416
Back pain 13.94 9.43 460 128997 209579 46347026
Dyspnoea exertional 13.92 9.43 82 129375 50207 46506398
Eosinophilic pneumonia acute 13.92 9.43 10 129447 355 46556250
Chronic fatigue syndrome 13.92 9.43 16 129441 1055 46555550
Skin ulcer 13.82 9.43 45 129412 32413 46524192
Sensation of blood flow 13.80 9.43 5 129452 38 46556567
Amenorrhoea 13.78 9.43 55 129402 8840 46547765
Osteonecrosis 13.72 9.43 32 129425 25712 46530893
Thrombosis 13.69 9.43 95 129362 55974 46500631
Emotional disorder 13.66 9.43 69 129388 12255 46544350
Purple glove syndrome 13.65 9.43 8 129449 199 46556406
Basilar migraine 13.58 9.43 5 129452 40 46556565
Gastrointestinal disorder 13.56 9.43 103 129354 59473 46497132
Sinusitis 13.50 9.43 266 129191 129502 46427103
Asthma 13.41 9.43 176 129281 91366 46465239
Red blood cell sedimentation rate increased 13.40 9.43 27 129430 22862 46533743
Biliary dyskinesia 13.37 9.43 26 129431 2747 46553858
Social anxiety disorder 13.35 9.43 10 129447 379 46556226
Floppy infant 13.33 9.43 6 129451 84 46556521
Libido decreased 13.26 9.43 25 129432 2580 46554025
Craniosynostosis 13.18 9.43 7 129450 143 46556462
Parkinsonian gait 13.15 9.43 11 129446 490 46556115
Blood urea increased 13.12 9.43 32 129425 25320 46531285
Pain in extremity 13.10 9.43 585 128872 258095 46298510
Accidental exposure to product 13.10 9.43 24 129433 21057 46535548
Sleep-related eating disorder 13.05 9.43 12 129445 607 46555998
Osteoporosis 13.03 9.43 63 129394 40545 46516060
Somnambulism 13.02 9.43 37 129420 5000 46551605
Loss of bladder sensation 12.97 9.43 5 129452 46 46556559
Multiple organ dysfunction syndrome 12.93 9.43 87 129370 51623 46504982
Blood pressure systolic increased 12.90 9.43 39 129418 28748 46527857
Mononucleosis syndrome 12.88 9.43 7 129450 150 46556455
Psychotic behaviour 12.87 9.43 12 129445 618 46555987
Oedema peripheral 12.77 9.43 341 129116 159365 46397240
Platelet dysfunction 12.72 9.43 6 129451 94 46556511
Transient aphasia 12.69 9.43 5 129452 49 46556556
Poor quality sleep 12.66 9.43 79 129378 15174 46541431
Metastases to bone 12.64 9.43 18 129439 17458 46539147
Tension 12.60 9.43 26 129431 2866 46553739
Thought insertion 12.60 9.43 3 129454 3 46556602
Obsessive thoughts 12.59 9.43 11 129446 520 46556085
Apgar score low 12.57 9.43 12 129445 637 46555968
Hypouricaemia 12.55 9.43 7 129450 158 46556447
Amaurosis 12.50 9.43 11 129446 525 46556080
Myelosuppression 12.47 9.43 3 129454 7700 46548905
Neutrophil count decreased 12.45 9.43 70 129387 43356 46513249
Medical diet 12.45 9.43 4 129453 20 46556585
Liver disorder 12.41 9.43 57 129400 37189 46519416
Anal incontinence 12.40 9.43 65 129392 11713 46544892
Pulmonary valve incompetence 12.39 9.43 17 129440 1341 46555264
Sudden cardiac death 12.36 9.43 22 129435 2173 46554432
Blood count abnormal 12.36 9.43 19 129438 17859 46538746
Agranulocytosis 12.29 9.43 27 129430 22158 46534447
Concussion 12.24 9.43 45 129412 6958 46549647
Hypersomnia 12.22 9.43 79 129378 15360 46541245
Phobia 12.18 9.43 9 129448 334 46556271
Derealisation 12.17 9.43 13 129444 790 46555815
Reactive psychosis 12.14 9.43 3 129454 4 46556601
Breast discomfort 12.11 9.43 9 129448 337 46556268
Ovarian germ cell cancer stage II 12.10 9.43 5 129452 56 46556549
Fluid overload 12.06 9.43 37 129420 27148 46529457
Thrombotic microangiopathy 12.03 9.43 4 129453 8302 46548303
Bronchitis 12.02 9.43 214 129243 105765 46450840
Proteinuria 12.02 9.43 17 129440 16536 46540069
Oesophageal adenocarcinoma 11.95 9.43 7 129450 174 46556431
Bacteraemia 11.93 9.43 13 129444 14166 46542439
Dysmorphism 11.90 9.43 20 129437 1887 46554718
Brucellosis 11.87 9.43 5 129452 59 46556546
Ventricular arrhythmia 11.79 9.43 28 129429 3393 46553212
Pain 11.76 9.43 1151 128306 475797 46080808
Illiteracy 11.74 9.43 3 129454 5 46556600
Lymphocytic hypophysitis 11.74 9.43 7 129450 180 46556425
Confabulation 11.70 9.43 8 129449 262 46556343
Pyloric stenosis 11.68 9.43 9 129448 356 46556249
Antidepressant drug level above therapeutic 11.68 9.43 9 129448 356 46556249
COVID-19 11.67 9.43 21 129436 18554 46538051
Ideas of reference 11.65 9.43 5 129452 62 46556543
Clostridium difficile colitis 11.63 9.43 21 129436 18532 46538073
Localised infection 11.58 9.43 31 129426 23770 46532835
Tooth extraction 11.50 9.43 7 129450 10186 46546419
Job dissatisfaction 11.45 9.43 4 129453 27 46556578
Discomfort 11.43 9.43 79 129378 46591 46510014
Hyperinsulinism 11.39 9.43 3 129454 6 46556599
Renal adenoma 11.39 9.43 3 129454 6 46556599
Unmasking of previously unidentified disease 11.37 9.43 12 129445 719 46555886
Bone erosion 11.35 9.43 6 129451 9437 46547168
Jaw clicking 11.32 9.43 4 129453 28 46556577
Paraesthesia 11.30 9.43 415 129042 117022 46439583
Trismus 11.30 9.43 28 129429 3487 46553118
Loss of consciousness 11.28 9.43 386 129071 107852 46448753
Rash pruritic 11.25 9.43 74 129383 44141 46512464
Urinary tract infection 11.17 9.43 498 128959 219768 46336837
Embolism 11.13 9.43 3 129454 7135 46549470
Panic disorder 11.13 9.43 23 129434 2538 46554067
Hypomania 11.11 9.43 32 129425 4356 46552249
Spina bifida occulta 11.08 9.43 3 129454 7 46556598
Rhinorrhoea 11.04 9.43 82 129375 47583 46509022
Cholecystectomy 11.01 9.43 52 129405 8990 46547615
Obsessive-compulsive symptom 10.97 9.43 4 129453 31 46556574
Cerebral infarction 10.94 9.43 31 129426 23335 46533270
Feelings of worthlessness 10.94 9.43 8 129449 292 46556313
Head deformity 10.92 9.43 5 129452 73 46556532
Purpura senile 10.91 9.43 11 129446 624 46555981
Influenza like illness 10.86 9.43 222 129235 57348 46499257
Initial insomnia 10.83 9.43 32 129425 4420 46552185
Autonomic nervous system imbalance 10.80 9.43 22 129435 2404 46554201
Acute stress disorder 10.78 9.43 7 129450 210 46556395
Communication disorder 10.75 9.43 22 129435 2411 46554194
Helicobacter infection 10.75 9.43 10 129447 11726 46544879
Metabolic acidosis 10.73 9.43 159 129298 38621 46517984
Myocardial infarction 10.73 9.43 198 129259 97330 46459275
Sternal fracture 10.71 9.43 17 129440 1529 46555076
Alcohol use 10.70 9.43 22 129435 2420 46554185
Theft 10.68 9.43 5 129452 77 46556528
Hypothermia 10.68 9.43 64 129393 12119 46544486
Cold agglutinins positive 10.65 9.43 4 129453 34 46556571
Hypoxic-ischaemic encephalopathy 10.60 9.43 30 129427 4043 46552562
Neonatal disorder 10.60 9.43 11 129446 646 46555959
Neonatal seizure 10.59 9.43 8 129449 307 46556298
Dizziness 10.55 9.43 1088 128369 339326 46217279
Premature delivery 10.54 9.43 29 129428 22040 46534565
Fatigue 10.53 9.43 1504 127953 607193 45949412
Feeling drunk 10.48 9.43 29 129428 3858 46552747
Sputum discoloured 10.44 9.43 12 129445 12766 46543839
Death of relative 10.38 9.43 7 129450 224 46556381
Haemorrhage intracranial 10.34 9.43 12 129445 12712 46543893
Tonic convulsion 10.33 9.43 14 129443 1092 46555513
Potentiating drug interaction 10.32 9.43 29 129428 3894 46552711
Base excess increased 10.30 9.43 3 129454 10 46556595
Joint hyperextension 10.30 9.43 7 129450 227 46556378
Pulmonary artery stenosis congenital 10.30 9.43 7 129450 227 46556378
Phonophobia 10.28 9.43 8 129449 321 46556284
Ataxia 10.25 9.43 70 129387 13860 46542745
Tenosynovitis 10.24 9.43 4 129453 7511 46549094
Diverticulitis 10.17 9.43 52 129405 32987 46523618
Death 10.13 9.43 797 128660 334751 46221854
Resorption bone increased 10.12 9.43 14 129443 1113 46555492
Bradykinesia 10.12 9.43 29 129428 3937 46552668
Gait disturbance 10.07 9.43 496 128961 144767 46411838
Spasmodic dysphonia 10.03 9.43 5 129452 89 46556516
Full blood count decreased 10.02 9.43 30 129427 22181 46534424
Skin infection 9.99 9.43 10 129447 11329 46545276
Yawning 9.98 9.43 12 129445 830 46555775
Impulse-control disorder 9.97 9.43 11 129446 693 46555912
Pleural disorder 9.85 9.43 10 129447 572 46556033
Ventricular septal defect 9.81 9.43 29 129428 4005 46552600
Breast cancer stage II 9.81 9.43 11 129446 706 46555899
Hypercalcaemia 9.80 9.43 28 129429 21018 46535587
Pneumocystis jirovecii pneumonia 9.80 9.43 17 129440 15231 46541374
Arnold-Chiari malformation 9.78 9.43 9 129448 456 46556149
Haemorrhage 9.78 9.43 101 129356 54768 46501837
Product deposit 9.77 9.43 6 129451 163 46556442
Fistula 9.76 9.43 5 129452 8005 46548600
Dehydration 9.74 9.43 353 129104 159187 46397418
Toxic skin eruption 9.73 9.43 12 129445 12375 46544230
Cholelithiasis 9.71 9.43 156 129301 38525 46518080
Alpha 2 globulin increased 9.69 9.43 5 129452 96 46556509
Rash maculo-papular 9.68 9.43 42 129415 27832 46528773
Epistaxis 9.65 9.43 123 129334 64182 46492423
Areflexia 9.63 9.43 24 129433 2999 46553606
Infective exacerbation of chronic obstructive airways disease 9.62 9.43 14 129443 1166 46555439
Therapeutic response decreased 9.62 9.43 75 129382 43070 46513535
Cellulitis 9.62 9.43 137 129320 70151 46486454
Hypotonia neonatal 9.56 9.43 12 129445 868 46555737
Transaminases increased 9.54 9.43 42 129415 27719 46528886
Accidental poisoning 9.53 9.43 10 129447 595 46556010
Serum serotonin decreased 9.51 9.43 3 129454 14 46556591
Shock 9.50 9.43 30 129427 21815 46534790
Lactation disorder 9.47 9.43 7 129450 260 46556345
Muscle neoplasm 9.44 9.43 4 129453 48 46556557

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 882.94 10.81 503 57050 17388 29877537
Completed suicide 399.36 10.81 698 56855 98794 29796131
Suicidal ideation 390.50 10.81 411 57142 35703 29859222
Toxicity to various agents 295.82 10.81 877 56676 176306 29718619
Intentional overdose 289.30 10.81 377 57176 41104 29853821
Suicide attempt 269.18 10.81 342 57211 36355 29858570
Drug interaction 268.46 10.81 917 56636 198651 29696274
Obsessive-compulsive disorder 246.85 10.81 132 57421 4009 29890916
Depression 222.58 10.81 518 57035 89919 29805006
Anxiety 217.07 10.81 511 57042 89360 29805565
Aggression 173.07 10.81 278 57275 36629 29858296
Akathisia 162.80 10.81 115 57438 5789 29889136
Agitation 159.21 10.81 333 57220 53740 29841185
Drug abuse 141.92 10.81 412 57141 81660 29813265
Drug withdrawal syndrome 134.81 10.81 178 57375 19631 29875294
Homicide 129.04 10.81 55 57498 991 29893934
Overdose 125.79 10.81 402 57151 83935 29810990
Euphoric mood 114.67 10.81 82 57471 4208 29890717
Psychotic disorder 113.28 10.81 171 57382 21344 29873581
Febrile neutropenia 111.99 10.81 33 57520 106660 29788265
Pneumonia 98.19 10.81 323 57230 333983 29560942
Electrocardiogram QT prolonged 89.87 10.81 207 57346 35628 29859297
Depressed mood 86.32 10.81 133 57420 16896 29878029
Paranoia 86.00 10.81 102 57451 10086 29884839
Anaemia 80.58 10.81 175 57378 207817 29687108
Antipsychotic drug level below therapeutic 79.70 10.81 43 57510 1329 29893596
Sepsis 78.16 10.81 100 57453 146295 29748630
Pyrexia 76.75 10.81 299 57254 294190 29600735
Thrombocytopenia 73.79 10.81 93 57460 136951 29757974
Exposure during pregnancy 73.72 10.81 90 57463 9171 29885754
Mania 72.93 10.81 89 57464 9065 29885860
Poisoning 70.91 10.81 98 57455 11284 29883641
Disinhibition 68 10.81 44 57509 1913 29893012
Suicidal behaviour 66.30 10.81 38 57515 1324 29893601
Malignant neoplasm progression 66.16 10.81 28 57525 72259 29822666
Social avoidant behaviour 63.67 10.81 49 57504 2814 29892111
Therapeutic product effect variable 62.96 10.81 37 57516 1352 29893573
Tremor 62.80 10.81 299 57254 75064 29819861
Increased appetite 62.53 10.81 65 57488 5552 29889373
Intentional self-injury 62.10 10.81 101 57452 13431 29881494
Tic 59.33 10.81 41 57512 1991 29892934
Affective disorder 58.03 10.81 48 57505 3060 29891865
Abnormal behaviour 56.66 10.81 141 57412 25482 29869443
Myoclonus 56.59 10.81 96 57457 13216 29881709
Irritability 54.34 10.81 130 57423 22920 29872005
Muscle twitching 53.49 10.81 72 57481 8083 29886842
Diarrhoea 52.30 10.81 402 57151 333701 29561224
Extrapyramidal disorder 52.07 10.81 82 57471 10611 29884314
Parasomnia 51.90 10.81 20 57533 274 29894651
Hallucination, auditory 51.78 10.81 78 57475 9711 29885214
Hyperreflexia 51.25 10.81 43 57510 2796 29892129
Anger 51.03 10.81 83 57470 11037 29883888
Dyskinesia 50.24 10.81 122 57431 21712 29873213
Tardive dyskinesia 50.08 10.81 55 57498 5002 29889923
Platelet count decreased 49.20 10.81 80 57473 106049 29788876
Panic attack 48.55 10.81 71 57482 8610 29886315
Disturbance in attention 48.12 10.81 121 57432 22008 29872917
Disease progression 47.49 10.81 50 57503 79824 29815101
Drug withdrawal syndrome neonatal 47.08 10.81 43 57510 3132 29891793
Haemoglobin decreased 46.62 10.81 93 57460 114005 29780920
Nightmare 46.02 10.81 83 57470 11993 29882932
Sexual dysfunction 45.64 10.81 57 57496 5944 29888981
Sedation 44.85 10.81 98 57455 16275 29878650
Drug dependence 44.80 10.81 115 57438 21180 29873745
Weight increased 44.55 10.81 271 57282 74642 29820283
Apathy 43.93 10.81 57 57496 6175 29888750
Mental disorder 43.28 10.81 86 57467 13363 29881562
Intentional product misuse 42.58 10.81 155 57398 34512 29860413
Blood prolactin increased 42.24 10.81 29 57524 1393 29893532
Hepatic function abnormal 42.13 10.81 14 57539 41931 29852994
Withdrawal syndrome 41.20 10.81 76 57477 11174 29883751
Atrial fibrillation 40.93 10.81 92 57461 108032 29786893
Neuroleptic malignant syndrome 40.68 10.81 94 57459 16201 29878724
Depersonalisation/derealisation disorder 40.68 10.81 20 57533 507 29894418
Renal impairment 40.39 10.81 62 57491 84122 29810803
Acute kidney injury 40.24 10.81 335 57218 273507 29621418
Visceral congestion 40.08 10.81 20 57533 524 29894401
Infection 39.91 10.81 55 57498 78019 29816906
Pancytopenia 39.51 10.81 64 57489 84988 29809937
Sleep disorder 39.47 10.81 120 57433 24359 29870566
Rheumatoid arthritis 39.24 10.81 15 57538 41182 29853743
Rash 38.50 10.81 214 57339 191675 29703250
Thinking abnormal 38.10 10.81 49 57504 5262 29889663
Homicidal ideation 37.78 10.81 34 57519 2429 29892496
Somnolence 37.68 10.81 316 57237 96447 29798478
Insomnia 37.51 10.81 307 57246 93029 29801896
General physical health deterioration 37.05 10.81 86 57467 99858 29795067
Drug abuser 37.04 10.81 44 57509 4357 29890568
Generalised tonic-clonic seizure 36.49 10.81 101 57452 19450 29875475
Antipsychotic drug level increased 35.89 10.81 37 57516 3129 29891796
Hyperhidrosis 35.72 10.81 236 57317 66854 29828071
Bipolar disorder 35.55 10.81 40 57513 3736 29891189
Bone marrow failure 35.55 10.81 7 57546 29778 29865147
Bruxism 34.09 10.81 25 57528 1334 29893591
Maternal drugs affecting foetus 33.15 10.81 41 57512 4232 29890693
Restlessness 32.95 10.81 107 57446 22492 29872433
Tearfulness 32.65 10.81 26 57527 1570 29893355
Social anxiety disorder 32.41 10.81 14 57539 261 29894664
Choreoathetosis 32.27 10.81 21 57532 922 29894003
Impulsive behaviour 31.88 10.81 28 57525 1937 29892988
Oculogyric crisis 31.60 10.81 24 57529 1351 29893574
Pleural effusion 31.43 10.81 59 57494 74007 29820918
Priapism 31.30 10.81 42 57511 4701 29890224
Dissociation 31.00 10.81 22 57531 1115 29893810
Persistent foetal circulation 30.77 10.81 15 57538 373 29894552
Torsade de pointes 30.75 10.81 52 57501 7138 29887787
Product complaint 30.33 10.81 46 57507 5760 29889165
Stomatitis 30.21 10.81 17 57536 37262 29857663
Muscle rigidity 29.92 10.81 63 57490 10198 29884727
Asphyxia 29.80 10.81 44 57509 5381 29889544
Delusion 29.75 10.81 69 57484 11920 29883005
Oral discharge 29.57 10.81 11 57542 136 29894789
Abnormal sleep-related event 29.55 10.81 16 57537 498 29894427
Nervousness 29.42 10.81 68 57485 11720 29883205
Mucosal inflammation 29.21 10.81 11 57542 30483 29864442
Obesity 29.09 10.81 56 57497 8499 29886426
Antidepressant drug level increased 28.78 10.81 10 57543 100 29894825
Abnormal dreams 28.68 10.81 54 57499 8061 29886864
Major depression 28.68 10.81 37 57516 3985 29890940
Mood swings 28.53 10.81 52 57501 7574 29887351
Hyperkalaemia 28.52 10.81 52 57501 65958 29828967
Environmental exposure 28.29 10.81 13 57540 282 29894643
Rhabdomyolysis 28.21 10.81 214 57339 63366 29831559
Derealisation 28.19 10.81 16 57537 547 29894378
Respiratory failure 28.17 10.81 99 57454 100543 29794382
Seizure 28.06 10.81 301 57252 98174 29796751
Renal failure 27.97 10.81 140 57413 128826 29766099
Septic shock 27.58 10.81 50 57503 63557 29831368
Memory impairment 27.04 10.81 142 57411 37032 29857893
Testis cancer 26.72 10.81 15 57538 502 29894423
Congenital aortic valve stenosis 26.57 10.81 10 57543 128 29894797
Libido decreased 26.48 10.81 38 57515 4528 29890397
Clonus 26.34 10.81 28 57525 2453 29892472
Agitation neonatal 26.04 10.81 19 57534 1006 29893919
Cyanosis neonatal 25.92 10.81 12 57541 265 29894660
Neonatal respiratory distress syndrome 25.67 10.81 35 57518 3977 29890948
Poisoning deliberate 25.65 10.81 43 57510 5861 29889064
Cytomegalovirus infection 25.40 10.81 7 57546 23667 29871258
Hallucination, tactile 25.28 10.81 12 57541 281 29894644
Myocardial infarction 25.21 10.81 140 57413 125485 29769440
Exposure via ingestion 25.16 10.81 28 57525 2583 29892342
Negative thoughts 25.16 10.81 16 57537 675 29894250
Huntington's disease 25.05 10.81 8 57545 60 29894865
Disseminated intravascular coagulation 24.85 10.81 6 57547 22165 29872760
Gastrointestinal haemorrhage 24.77 10.81 80 57473 83366 29811559
Emotional disorder 24.71 10.81 39 57514 5055 29889870
Restless legs syndrome 24.63 10.81 46 57507 6826 29888099
Interstitial lung disease 24.62 10.81 49 57504 60148 29834777
Neutropenia 24.32 10.81 146 57407 128394 29766531
Prescribed overdose 24.31 10.81 52 57501 8509 29886416
Foetal exposure during pregnancy 24.23 10.81 137 57416 36734 29858191
Obsessive-compulsive symptom 24.17 10.81 8 57545 68 29894857
Cardiac failure 24.06 10.81 81 57472 83337 29811588
Herpes zoster 23.77 10.81 14 57539 29929 29864996
Initial insomnia 23.65 10.81 27 57526 2562 29892363
Hostility 23.60 10.81 17 57536 882 29894043
Compulsions 23.37 10.81 10 57543 182 29894743
Violence-related symptom 23.30 10.81 14 57539 533 29894392
Dreamy state 23.26 10.81 6 57547 18 29894907
Coma 23.18 10.81 145 57408 40304 29854621
Obsessive thoughts 23.10 10.81 15 57538 656 29894269
Dystonia 23.07 10.81 55 57498 9672 29885253
Accidental death 23.03 10.81 24 57529 2055 29892870
Tourette's disorder 22.94 10.81 8 57545 81 29894844
Oculoauriculovertebral dysplasia 22.83 10.81 5 57548 5 29894920
Parkinsonism 22.81 10.81 46 57507 7223 29887702
Chorea 22.80 10.81 18 57535 1073 29893852
Neuropathy peripheral 22.75 10.81 65 57488 70410 29824515
Blunted affect 22.44 10.81 11 57542 277 29894648
Colitis 22.30 10.81 16 57537 30804 29864121
Selective mutism 22.21 10.81 7 57546 50 29894875
Alcoholism 22.17 10.81 30 57523 3384 29891541
Serum ferritin abnormal 22.02 10.81 10 57543 211 29894714
Flat affect 21.96 10.81 16 57537 845 29894080
Dyspnoea 21.95 10.81 481 57072 332814 29562111
Cholinergic syndrome 21.83 10.81 13 57540 487 29894438
Hallucination 21.68 10.81 165 57388 48894 29846031
Lethargy 21.62 10.81 140 57413 39379 29855546
Treatment failure 21.40 10.81 21 57532 34658 29860267
Pulmonary embolism 21.10 10.81 78 57475 78057 29816868
Mood altered 21.04 10.81 48 57505 8202 29886723
Urobilinogen urine 21.03 10.81 4 57549 0 29894925
Serum serotonin decreased 21.03 10.81 4 57549 0 29894925
Neonatal disorder 20.92 10.81 16 57537 910 29894015
Mydriasis 20.63 10.81 40 57513 6103 29888822
Vascular stenosis 20.58 10.81 9 57544 173 29894752
Eye movement disorder 20.11 10.81 31 57522 3937 29890988
Congenital hand malformation 20.04 10.81 12 57541 454 29894471
Psychomotor hyperactivity 20.04 10.81 47 57506 8177 29886748
Gambling disorder 19.95 10.81 21 57532 1819 29893106
Alcohol poisoning 19.92 10.81 30 57523 3734 29891191
Loss of libido 19.86 10.81 22 57531 2020 29892905
Urinary tract discomfort 19.80 10.81 7 57546 74 29894851
Plasma cell myeloma 19.80 10.81 46 57507 53416 29841509
Antisocial behaviour 19.73 10.81 10 57543 271 29894654
Ascites 19.69 10.81 24 57529 35897 29859028
Victim of child abuse 19.43 10.81 10 57543 280 29894645
Tremor neonatal 19.35 10.81 11 57542 377 29894548
Drug level increased 19.20 10.81 78 57475 18276 29876649
Loss of employment 19.11 10.81 12 57541 495 29894430
Child abuse 18.91 10.81 9 57544 212 29894713
Self-injurious ideation 18.59 10.81 19 57534 1590 29893335
Erythema 18.59 10.81 81 57472 77370 29817555
Post 5-alpha-reductase inhibitor syndrome 18.56 10.81 6 57547 47 29894878
Infusion related reaction 18.38 10.81 31 57522 40533 29854392
Poor quality sleep 18.32 10.81 42 57511 7199 29887726
Renal ischaemia 18.31 10.81 12 57541 533 29894392
Retinal phototoxicity 18.26 10.81 4 57549 4 29894921
White blood cell count decreased 18.26 10.81 91 57462 83856 29811069
Congenital aortic valve incompetence 18.24 10.81 8 57545 155 29894770
Phobia 18.16 10.81 7 57546 96 29894829
Chronic actinic dermatitis 18.08 10.81 5 57548 21 29894904
Yawning 18.08 10.81 12 57541 545 29894380
Lymphocyte count decreased 18.04 10.81 7 57546 19048 29875877
Product substitution issue 17.90 10.81 51 57502 9984 29884941
Compulsive shopping 17.89 10.81 11 57542 437 29894488
Pituitary tumour benign 17.88 10.81 14 57539 825 29894100
Cognitive disorder 17.58 10.81 91 57462 23599 29871326
Cardiac arrest 17.54 10.81 263 57290 92587 29802338
Cerebral infarction 17.43 10.81 15 57538 26358 29868567
Confusional state 17.27 10.81 359 57194 134475 29760450
Atrial septal defect 17.10 10.81 39 57514 6662 29888263
Tachyphrenia 17.04 10.81 15 57538 1041 29893884
Compulsive hoarding 16.90 10.81 5 57548 28 29894897
Hypersomnia 16.88 10.81 54 57499 11262 29883663
Blood cholesterol increased 16.87 10.81 71 57482 16899 29878026
Autonomic nervous system imbalance 16.84 10.81 22 57531 2399 29892526
Respiratory arrest 16.83 10.81 105 57448 29153 29865772
Coagulation factor VII level decreased 16.79 10.81 7 57546 119 29894806
Oedema 16.73 10.81 36 57517 42957 29851968
Physical deconditioning 16.64 10.81 12 57541 624 29894301
Off label use 16.60 10.81 359 57194 248931 29645994
Muscle necrosis 16.53 10.81 13 57540 771 29894154
Vasoplegia syndrome 16.52 10.81 16 57537 1255 29893670
Dyslipidaemia 16.51 10.81 35 57518 5692 29889233
Feeling guilty 16.20 10.81 9 57544 295 29894630
Liver disorder 16.14 10.81 20 57533 29702 29865223
Somnambulism 16.14 10.81 25 57528 3189 29891736
Blood creatinine increased 16.13 10.81 106 57447 91269 29803656
Myelodysplastic syndrome 16.04 10.81 8 57545 18770 29876155
Erectile dysfunction 15.91 10.81 73 57480 18029 29876896
Self esteem decreased 15.90 10.81 11 57542 535 29894390
Cardiac failure congestive 15.88 10.81 96 57457 84311 29810614
Alcohol use 15.85 10.81 27 57526 3728 29891197
Electrocardiogram QRS complex prolonged 15.79 10.81 29 57524 4248 29890677
Delayed sleep phase 15.77 10.81 3 57550 0 29894925
Microsomia 15.77 10.81 3 57550 0 29894925
Dissociative disorder 15.75 10.81 7 57546 140 29894785
Dysphoria 15.69 10.81 20 57533 2128 29892797
Candida infection 15.65 10.81 5 57548 15357 29879568
Renal artery thrombosis 15.64 10.81 9 57544 316 29894609
Salivary gland cancer stage IV 15.48 10.81 5 57548 39 29894886
Feeling abnormal 15.46 10.81 172 57381 56584 29838341
Hepatic failure 15.44 10.81 26 57527 34017 29860908
Pruritus 15.37 10.81 149 57404 118055 29776870
Miosis 15.33 10.81 41 57512 7735 29887190
Spina bifida 15.19 10.81 9 57544 334 29894591
Grandiosity 15.19 10.81 9 57544 334 29894591
Pneumocystis jirovecii pneumonia 15.07 10.81 7 57546 17113 29877812
Suspected suicide 15.05 10.81 24 57529 3137 29891788
Blood glucose fluctuation 15.03 10.81 26 57527 3635 29891290
Anaphylactic reaction 15.01 10.81 19 57534 27963 29866962
Mutism 14.96 10.81 12 57541 732 29894193
Neoplasm progression 14.92 10.81 8 57545 18015 29876910
Sarcoma metastatic 14.90 10.81 6 57547 93 29894832
Pupil fixed 14.90 10.81 18 57535 1814 29893111
Basilar migraine 14.82 10.81 4 57549 15 29894910
Small for dates baby 14.79 10.81 24 57529 3184 29891741
Hypertonia neonatal 14.69 10.81 9 57544 355 29894570
Cerebrovascular stenosis 14.67 10.81 6 57547 97 29894828
Posture abnormal 14.65 10.81 18 57535 1846 29893079
Arnold-Chiari malformation 14.63 10.81 8 57545 254 29894671
Peripheral swelling 14.57 10.81 64 57489 61010 29833915
Transposition of the great vessels 14.53 10.81 10 57543 482 29894443
Hypogonadism male 14.46 10.81 8 57545 260 29894665
Premature baby 14.44 10.81 67 57486 16624 29878301
Staring 14.37 10.81 16 57537 1477 29893448
Eye colour change 14.35 10.81 8 57545 264 29894661
Peritonitis 14.31 10.81 12 57541 21363 29873562
Blood urea increased 14.20 10.81 24 57529 31357 29863568
Coma uraemic 14.13 10.81 5 57548 53 29894872
Negativism 14.12 10.81 9 57544 381 29894544
Sleep apnoea syndrome 14.10 10.81 67 57486 16790 29878135
Deep vein thrombosis 14.08 10.81 64 57489 60437 29834488
Salivary hypersecretion 14.03 10.81 39 57514 7527 29887398
Otosalpingitis 13.90 10.81 4 57549 20 29894905
Alpha 2 globulin decreased 13.90 10.81 4 57549 20 29894905
Faecal calprotectin 13.90 10.81 4 57549 20 29894905
Accommodation disorder 13.87 10.81 7 57546 188 29894737
Drug resistance 13.86 10.81 11 57542 20122 29874803
Appendicitis perforated 13.85 10.81 17 57536 1741 29893184
Decreased interest 13.82 10.81 19 57534 2176 29892749
Arthralgia 13.78 10.81 181 57372 135610 29759315
Free androgen index decreased 13.74 10.81 4 57549 21 29894904
Sex hormone binding globulin decreased 13.74 10.81 4 57549 21 29894904
Blood creatine phosphokinase MB 13.70 10.81 3 57550 3 29894922
Blood luteinising hormone decreased 13.69 10.81 6 57547 116 29894809
Chronic kidney disease 13.65 10.81 33 57520 37805 29857120
Hyperbilirubinaemia neonatal 13.60 10.81 11 57542 679 29894246
Androgen insensitivity syndrome 13.58 10.81 4 57549 22 29894903
Viral acanthoma 13.58 10.81 4 57549 22 29894903
Dehydration 13.53 10.81 162 57391 123377 29771548
Secondary hypogonadism 13.50 10.81 8 57545 297 29894628
Tinnitus 13.50 10.81 64 57489 16024 29878901
Tumour lysis syndrome 13.47 10.81 4 57549 12881 29882044
Creatinine urine decreased 13.43 10.81 4 57549 23 29894902
Hepatitis E virus test positive 13.43 10.81 4 57549 23 29894902
Feeling drunk 13.32 10.81 16 57537 1603 29893322
Testicular microlithiasis 13.29 10.81 4 57549 24 29894901
Dehydroepiandrosterone decreased 13.29 10.81 4 57549 24 29894901
Blood lactate dehydrogenase increased 13.27 10.81 12 57541 20589 29874336
Palmar-plantar erythrodysaesthesia syndrome 13.21 10.81 6 57547 14864 29880061
Drooling 13.21 10.81 22 57531 2983 29891942
Ear discomfort 13.20 10.81 19 57534 2270 29892655
Inflammatory bowel disease 13.18 10.81 19 57534 2274 29892651
Retrograde ejaculation 13.17 10.81 8 57545 311 29894614
Urine calcium/creatinine ratio increased 13.15 10.81 4 57549 25 29894900
Neutrophil count decreased 13.08 10.81 40 57513 42414 29852511
Tongue injury 13.06 10.81 6 57547 130 29894795
Treatment noncompliance 12.92 10.81 88 57465 25165 29869760
Peritonitis bacterial 12.91 10.81 3 57550 11375 29883550
Feeling jittery 12.85 10.81 25 57528 3823 29891102
Pain 12.85 10.81 244 57309 172397 29722528
Plagiocephaly 12.83 10.81 8 57545 326 29894599
Dysphemia 12.78 10.81 15 57538 1466 29893459
Marital problem 12.75 10.81 5 57548 72 29894853
Symptom masked 12.72 10.81 9 57544 454 29894471
Psychiatric symptom 12.59 10.81 23 57530 3356 29891569
Cough 12.55 10.81 168 57385 125474 29769451
Bronchopulmonary aspergillosis 12.51 10.81 4 57549 12280 29882645
Hyperdynamic left ventricle 12.50 10.81 5 57548 76 29894849
Intrusive thoughts 12.50 10.81 5 57548 76 29894849
Atrial conduction time prolongation 12.49 10.81 3 57550 6 29894919
Alcohol abuse 12.40 10.81 30 57523 5323 29889602
Haematochezia 12.23 10.81 30 57523 34192 29860733
Thought insertion 12.17 10.81 3 57550 7 29894918
Type 2 diabetes mellitus 12.02 10.81 55 57498 13567 29881358
Cataplexy 12.02 10.81 8 57545 365 29894560
COVID-19 12.02 10.81 10 57543 17868 29877057
Renal dysplasia 11.96 10.81 6 57547 159 29894766
Ejaculation disorder 11.90 10.81 12 57541 988 29893937
Pulmonary congestion 11.90 10.81 51 57502 12236 29882689
Melanocytic hyperplasia 11.89 10.81 3 57550 8 29894917
Thyroxine free abnormal 11.89 10.81 3 57550 8 29894917
Poor feeding infant 11.86 10.81 8 57545 373 29894552
Mental impairment 11.83 10.81 42 57511 9235 29885690
Locked-in syndrome 11.78 10.81 7 57546 261 29894664
Dermal cyst 11.75 10.81 14 57539 1390 29893535
Bradycardia 11.75 10.81 184 57369 65342 29829583
Self-medication 11.74 10.81 18 57535 2276 29892649
Alpha globulin increased 11.63 10.81 3 57550 9 29894916
Panic reaction 11.60 10.81 14 57539 1409 29893516
Opisthotonus 11.55 10.81 8 57545 390 29894535
Hospitalisation 11.47 10.81 45 57508 44274 29850651
Aorta hypoplasia 11.44 10.81 5 57548 96 29894829
Antipsychotic drug level decreased 11.42 10.81 11 57542 857 29894068
Posturing 11.39 10.81 9 57544 537 29894388
C-reactive protein increased 11.34 10.81 44 57509 43429 29851496
Economic problem 11.34 10.81 14 57539 1443 29893482
Respiratory depression 11.33 10.81 48 57505 11455 29883470
Schizoaffective disorder 11.32 10.81 12 57541 1048 29893877
Terminal insomnia 11.24 10.81 8 57545 407 29894518
Altered state of consciousness 11.24 10.81 13 57540 19906 29875019
Antipsychotic drug level above therapeutic 11.23 10.81 12 57541 1058 29893867
Atrioventricular block first degree 11.23 10.81 30 57523 5658 29889267
Torticollis 11.18 10.81 12 57541 1063 29893862
Alcohol problem 11.16 10.81 5 57548 102 29894823
Bradypnoea 11.16 10.81 16 57537 1905 29893020
Condition aggravated 11.10 10.81 345 57208 137521 29757404
Coordination abnormal 11.02 10.81 35 57518 7270 29887655
Multiple organ dysfunction syndrome 11.02 10.81 74 57479 63413 29831512
Drug titration error 11.01 10.81 8 57545 421 29894504
Aspartate aminotransferase increased 10.97 10.81 74 57479 63348 29831577
Urine phosphorus decreased 10.94 10.81 4 57549 47 29894878
Cerebral haemorrhage 10.85 10.81 30 57523 32857 29862068
Thrombosis 10.85 10.81 43 57510 42188 29852737
Cortisol increased 10.82 10.81 6 57547 196 29894729

Pharmacologic Action:

SourceCodeDescription
ATC N06AB03 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
ATC N06CA03 NERVOUS SYSTEM
PSYCHOANALEPTICS
PSYCHOLEPTICS AND PSYCHOANALEPTICS IN COMBINATION
Antidepressants in combination with psycholeptics
FDA MoA N0000000109 Serotonin Uptake Inhibitors
FDA EPC N0000175696 Serotonin Reuptake Inhibitor
CHEBI has role CHEBI:35469 thymoanaleptics
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:50949 serotonin reuptake inhibitor
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:88188 allergenic drug
MeSH PA D000928 Antidepressive Agents
MeSH PA D018687 Antidepressive Agents, Second-Generation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D065690 Cytochrome P-450 CYP2D6 Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D017367 Serotonin Uptake Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Premenstrual dysphoric disorder indication 596004
Depressive disorder indication 35489007
Bulimia nervosa indication 78004001
Bipolar affective disorder, current episode depression indication 191627008 DOID:3312
Obsessive-compulsive disorder indication 191736004 DOID:10933
Major depressive disorder indication 370143000
Panic disorder indication 371631005 DOID:594
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Postpartum depression off-label use 58703003 DOID:9478
Cataplexy and narcolepsy off-label use 193042000
Menopausal flushing off-label use 198436008
Fibromyalgia off-label use 203082005 DOID:631
Seasonal affective disorder off-label use 247803002
Suicidal thoughts contraindication 6471006
Weight gain finding contraindication 8943002
Sinus tachycardia contraindication 11092001
Hypercholesterolemia contraindication 13644009
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Cirrhosis of liver contraindication 19943007 DOID:5082
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Dehydration contraindication 34095006
Upper gastrointestinal hemorrhage contraindication 37372002
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Paralytic ileus contraindication 55525008 DOID:8442
Hyperlipidemia contraindication 55822004 DOID:1168
Anorexia nervosa contraindication 56882008 DOID:8689
Abnormal sexual function contraindication 56925008
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Heart failure contraindication 84114007 DOID:6000
Epilepsy contraindication 84757009 DOID:1826
Leukopenia contraindication 84828003 DOID:615
Hyponatremia contraindication 89627008
Tardive dyskinesia contraindication 102449007
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Cerebrovascular accident contraindication 230690007
Mania contraindication 231494001
Hypomania contraindication 231496004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Transient ischemic attack contraindication 266257000 DOID:224
Esophageal dysmotility contraindication 266434009 DOID:9192
Benign prostatic hyperplasia contraindication 266569009
Hypertriglyceridemia contraindication 302870006
Neutropenic disorder contraindication 303011007 DOID:1227
Serotonin syndrome contraindication 371089000
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.32 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 9.09 WOMBAT-PK CHEMBL
Muscarinic acetylcholine receptor M4 GPCR Ki 5.54 PDSP
Muscarinic acetylcholine receptor M2 GPCR Ki 5.57 PDSP
5-hydroxytryptamine receptor 2B GPCR ANTAGONIST Ki 5.30 IUPHAR
Alpha-2B adrenergic receptor GPCR Ki 6.16 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 6.15 DRUG MATRIX
Acetylcholinesterase Enzyme IC50 6.89 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 6.07 CHEMBL
Histamine H3 receptor GPCR Ki 5.14 CHEMBL
Sodium-dependent dopamine transporter Transporter Kd 5.44 WOMBAT-PK
Muscarinic acetylcholine receptor M3 GPCR Ki 6 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 6.05 WOMBAT-PK
Histamine H1 receptor GPCR Ki 5.96 WOMBAT-PK
D(3) dopamine receptor GPCR Ki 5.70 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR Ki 6.40 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR Ki 6.61 WOMBAT-PK
Sodium-dependent noradrenaline transporter Transporter Kd 6.62 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.15 WOMBAT-PK
Beta-1 adrenergic receptor GPCR Ki 5.36 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 5.70 PDSP
Alpha-2A adrenergic receptor GPCR Ki 8.20 CHEMBL
Equilibrative nucleoside transporter 4 Transporter INHIBITOR Ki 4.64 IUPHAR
Muscarinic acetylcholine receptor M5 GPCR Ki 5.57 PDSP
Sodium-dependent serotonin transporter Transporter Ki 8.70 CHEMBL
Transporter Transporter Ki 6.80 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 7.97 CHEMBL
Transporter Transporter Ki 6.84 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 6.22 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 6.11 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 5.72 CHEMBL
Potassium voltage-gated channel subfamily C member 1 Unclassified IC50 4.88 CHEMBL
Serotonin 1 (5-HT1) receptor GPCR IC50 7.82 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 7.07 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 6.96 CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 6.50 IUPHAR
5-hydroxytryptamine receptor 6 GPCR ANTAGONIST Ki 5.80 IUPHAR
G protein-activated inward rectifier potassium channel 2 Ion channel GATING INHIBITOR IC50 4.80 IUPHAR

External reference:

IDSource
D00326 KEGG_DRUG
56296-78-7 SECONDARY_CAS_RN
4019389 VANDF
4019761 VANDF
C0016365 UMLSCUI
CHEBI:5118 CHEBI
RFX PDB_CHEM_ID
CHEMBL41 ChEMBL_ID
CHEMBL153036 ChEMBL_ID
CHEMBL1201082 ChEMBL_ID
DB00472 DRUGBANK_ID
D005473 MESH_DESCRIPTOR_UI
203 IUPHAR_LIGAND_ID
3883 INN_ID
01K63SUP8D UNII
3386 PUBCHEM_CID
227224 RXNORM
17711 MMSL
37675 MMSL
4091 MMSL
41730 MMSL
4746 MMSL
d00236 MMSL
001514 NDDF
004613 NDDF
372767007 SNOMEDCT_US
53640004 SNOMEDCT_US
75115009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3230 CAPSULE 25 mg ORAL NDA 34 sections
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3231 CAPSULE 25 mg ORAL NDA 34 sections
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3232 CAPSULE 25 mg ORAL NDA 34 sections
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3233 CAPSULE 50 mg ORAL NDA 34 sections
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3234 CAPSULE 50 mg ORAL NDA 34 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-0807 TABLET, FILM COATED 20 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5262 TABLET, FILM COATED 60 mg ORAL ANDA 31 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5503 CAPSULE 25 mg ORAL ANDA 32 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5504 CAPSULE 25 mg ORAL ANDA 32 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5505 CAPSULE 50 mg ORAL ANDA 32 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5506 CAPSULE 25 mg ORAL ANDA 32 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5507 CAPSULE 50 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7188 TABLET, FILM COATED 10 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7198 CAPSULE 40 mg ORAL ANDA 31 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0121-0721 SOLUTION 20 mg ORAL ANDA 33 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0121-0721 SOLUTION 20 mg ORAL ANDA 33 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0121-4721 SOLUTION 20 mg ORAL ANDA 33 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0121-4721 SOLUTION 20 mg ORAL ANDA 33 sections
SARAFEM HUMAN PRESCRIPTION DRUG LABEL 1 0430-0210 TABLET 10 mg ORAL NDA 34 sections
SARAFEM HUMAN PRESCRIPTION DRUG LABEL 1 0430-0215 TABLET 15 mg ORAL NDA 34 sections
SARAFEM HUMAN PRESCRIPTION DRUG LABEL 1 0430-0220 TABLET 20 mg ORAL NDA 34 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-1384 CAPSULE 10 mg ORAL ANDA 33 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-7625 CAPSULE 20 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-7638 CAPSULE 10 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8093 CAPSULE 10 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8183 CAPSULE 40 mg ORAL ANDA 33 sections
Prozac HUMAN PRESCRIPTION DRUG LABEL 1 0777-3104 CAPSULE 10 mg ORAL NDA 35 sections
Prozac HUMAN PRESCRIPTION DRUG LABEL 1 0777-3105 CAPSULE 20 mg ORAL NDA 35 sections
Prozac HUMAN PRESCRIPTION DRUG LABEL 1 0777-3107 CAPSULE 40 mg ORAL NDA 35 sections
Fluoxetine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-2822 CAPSULE 20 mg ORAL ANDA 31 sections