fluoxetine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives	1209	54910-89-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: prozac fluoxetine fluoxetine hydrochloride fluoxetin fluoxetine HCl	The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants. Molecular weight: 309.33 Formula: C17H18F3NO CLOGP: 4.57 LIPINSKI: 0 HAC: 2 HDO: 1 TPSA: 21.26 ALOGS: -5.26 ROTB: 7 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

prozac
fluoxetine
fluoxetine hydrochloride
fluoxetin
fluoxetine HCl

The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.

Molecular weight: 309.33
Formula: C17H18F3NO
CLOGP: 4.57
LIPINSKI: 0
HAC: 2
HDO: 1
TPSA: 21.26
ALOGS: -5.26
ROTB: 7

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
20	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	14 mg/mL	Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine)	1.25 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	4.30 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	60 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
fu (Fraction unbound in plasma)	0.02 %	Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

Date	Agency	Company	Orphan
Dec. 29, 1987	FDA	ELI LILLY AND CO

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	1679.45	9.67	1886	147625	143787	63195724
Intentional overdose	1039.73	9.67	1066	148445	73086	63266425
Toxicity to various agents	982.12	9.67	1939	147572	245311	63094200
Suicidal ideation	879.69	9.67	900	148611	61521	63277990
Drug abuse	610.62	9.67	802	148709	71716	63267795
Serotonin syndrome	591.26	9.67	511	149000	28171	63311340
Suicide attempt	589.33	9.67	722	148789	60196	63279315
Intentional self-injury	585.70	9.67	485	149026	25202	63314309
Drug interaction	557.91	9.67	1482	148029	227649	63111862
Electrocardiogram QT prolonged	404.55	9.67	594	148917	58936	63280575
Systemic lupus erythematosus	367.84	9.67	34	149477	208884	63130627
Synovitis	355.87	9.67	21	149490	186897	63152614
Tremor	355.02	9.67	888	148623	131351	63208160
Hand deformity	345.15	9.67	6	149505	159451	63180060
Cardio-respiratory arrest	322.07	9.67	537	148974	59422	63280089
Anxiety	318.36	9.67	1180	148331	216361	63123150
Contraindicated product administered	309.88	9.67	67	149444	217581	63121930
Agitation	294.34	9.67	515	148996	59242	63280269
Glossodynia	280.59	9.67	43	149468	178833	63160678
Joint swelling	272.82	9.67	223	149288	327443	63012068
Wound	258.93	9.67	38	149473	163225	63176286
Infusion related reaction	256.35	9.67	129	149382	245392	63094119
Drug intolerance	255.78	9.67	211	149300	308450	63031061
Overdose	255.21	9.67	720	148791	114358	63225153
Drug withdrawal syndrome	254.26	9.67	317	149194	26877	63312634
Depression	250.80	9.67	1021	148490	195471	63144040
Pericarditis	243.80	9.67	17	149494	131562	63207949
Cardiac arrest	242.52	9.67	616	148895	91929	63247582
Alopecia	241.93	9.67	263	149248	337273	63002238
Treatment failure	240.81	9.67	84	149427	198959	63140552
Arthropathy	231	9.67	133	149378	234659	63104852
Respiratory arrest	229.33	9.67	331	149180	32314	63307197
Swelling	219.86	9.67	195	149316	275183	63064328
Withdrawal syndrome	219.60	9.67	253	149258	19744	63319767
Abdominal discomfort	219.09	9.67	260	149251	320625	63018886
Somnolence	208.09	9.67	903	148608	177782	63161729
Poisoning	200.90	9.67	202	149309	13498	63326013
Rash	192.74	9.67	677	148834	560194	62779317
Irritability	190.76	9.67	299	149212	31395	63308116
Reversible cerebral vasoconstriction syndrome	188.96	9.67	102	149409	2556	63336955
Torsade de pointes	179.73	9.67	188	149323	13163	63326348
Rheumatoid factor positive	179.27	9.67	4	149507	84402	63255109
Helicobacter infection	174.77	9.67	11	149500	92774	63246737
Duodenal ulcer perforation	171.54	9.67	8	149503	87201	63252310
Peripheral swelling	170.46	9.67	226	149285	265716	63073795
Hepatic enzyme increased	167.85	9.67	138	149373	202190	63137321
Sopor	163.42	9.67	230	149281	21934	63317577
Akathisia	158.85	9.67	148	149363	8998	63330513
Poisoning deliberate	158.28	9.67	162	149349	11056	63328455
Therapeutic product effect decreased	157.49	9.67	134	149377	193053	63146458
Disturbance in attention	153.92	9.67	302	149209	37887	63301624
Aggression	144.63	9.67	224	149287	23274	63316237
Depressed mood	144.36	9.67	303	149208	39888	63299623
Arthralgia	142.40	9.67	775	148736	568935	62770576
Infection	141.54	9.67	200	149311	228973	63110538
Coma	140.91	9.67	401	149110	63963	63275548
Drug ineffective	140.32	9.67	1683	147828	1043082	62296429
Product use issue	139.64	9.67	189	149322	220331	63119180
Nightmare	135.35	9.67	195	149316	18999	63320512
Discomfort	134.09	9.67	118	149393	167256	63172255
Folliculitis	133.43	9.67	8	149503	70309	63269202
Suicidal behaviour	130.64	9.67	80	149431	2559	63336952
Blister	124.10	9.67	76	149435	129738	63209773
Seizure	124.00	9.67	629	148882	132005	63207506
Panic attack	123.86	9.67	203	149308	22128	63317383
Febrile neutropenia	123.86	9.67	62	149449	118387	63221124
Mania	123.40	9.67	149	149362	12218	63327293
Respiratory depression	122.03	9.67	156	149355	13559	63325952
Rheumatoid arthritis	120.84	9.67	261	149250	253558	63085953
Muscle injury	119.40	9.67	9	149502	65336	63274175
Crying	117.24	9.67	203	149308	23140	63316371
Hypersensitivity	110.82	9.67	338	149173	292347	63047164
White blood cell count abnormal	110.32	9.67	102	149409	6140	63333371
Mydriasis	109.55	9.67	138	149373	11818	63327693
Product complaint	108.19	9.67	142	149369	12667	63326844
Lower respiratory tract infection	107.51	9.67	92	149419	132215	63207296
Sleep disorder due to general medical condition, insomnia type	105.31	9.67	4	149507	52213	63287298
Depressed level of consciousness	104.53	9.67	353	149158	61725	63277786
Foetal exposure during pregnancy	104.51	9.67	232	149279	31730	63307781
Suspected suicide	104.01	9.67	101	149410	6467	63333044
Impaired healing	103.75	9.67	56	149455	102486	63237025
Product substitution issue	101.98	9.67	155	149356	15841	63323670
Muscle rigidity	97.92	9.67	128	149383	11372	63328139
Galactorrhoea	97.90	9.67	80	149431	4075	63335436
Stomatitis	96.02	9.67	111	149400	138614	63200897
Nasopharyngitis	95.95	9.67	294	149217	253963	63085548
Electrocardiogram QRS complex prolonged	93.45	9.67	91	149420	5847	63333664
General physical health deterioration	91.00	9.67	213	149298	201189	63138322
Bezoar	90.55	9.67	52	149459	1474	63338037
Tardive dyskinesia	89.05	9.67	105	149406	8397	63331114
Rheumatic fever	87.99	9.67	3	149508	43108	63296403
Coma scale abnormal	86.82	9.67	82	149429	5071	63334440
Dystonia	85.41	9.67	132	149379	13687	63325824
Pneumonia	84.80	9.67	679	148832	456088	62883423
Self-injurious ideation	84.13	9.67	61	149450	2598	63336913
Generalised tonic-clonic seizure	83.18	9.67	200	149311	28816	63310695
Anger	79.83	9.67	121	149390	12335	63327176
Muscle twitching	78.59	9.67	155	149356	19513	63319998
Insomnia	78.29	9.67	813	148698	214439	63125072
Mobility decreased	77.49	9.67	103	149408	121056	63218455
Extrapyramidal disorder	76.71	9.67	123	149388	13161	63326350
Abnormal behaviour	76.31	9.67	161	149350	21265	63318246
Neutropenia	75.95	9.67	189	149322	174816	63164695
Drug dependence	75.90	9.67	174	149337	24309	63315202
Tearfulness	75.80	9.67	69	149442	4070	63335441
Off label use	73.62	9.67	1132	148379	673330	62666181
Obsessive-compulsive disorder	73.02	9.67	67	149444	3993	63335518
Restlessness	72.90	9.67	192	149319	29261	63310250
Gastrointestinal disorder	72.85	9.67	123	149388	131116	63208395
Mood swings	71.93	9.67	143	149368	18105	63321406
Pyrexia	70.95	9.67	737	148774	469741	62869770
Miosis	70.78	9.67	87	149424	7266	63332245
Intentional product use issue	69.94	9.67	121	149390	127771	63211740
Hypertonia neonatal	69.90	9.67	25	149486	219	63339292
Myoclonus	69.47	9.67	130	149381	15738	63323773
Hyperhidrosis	69.17	9.67	463	149048	107373	63232138
Dyskinesia	68.67	9.67	198	149313	31804	63307707
C-reactive protein increased	68.57	9.67	73	149438	94634	63244877
Therapeutic product effect incomplete	67.77	9.67	119	149392	124937	63214574
Parkinsonism	67.74	9.67	102	149409	10337	63329174
Hyperprolactinaemia	67.51	9.67	63	149448	3837	63335674
Ill-defined disorder	67.44	9.67	56	149455	81699	63257812
Restless legs syndrome	66.87	9.67	140	149371	18391	63321120
Hip arthroplasty	65.07	9.67	16	149495	47630	63291881
Pain	63.93	9.67	1296	148215	739332	62600179
Disease progression	62.80	9.67	121	149390	122637	63216874
Hallucination, auditory	62.41	9.67	110	149401	12714	63326797
Intentional product misuse	61.94	9.67	296	149215	60621	63278890
Emotional distress	61.92	9.67	193	149318	32356	63307155
Paranoia	61.85	9.67	104	149407	11575	63327936
Drug withdrawal syndrome neonatal	59.69	9.67	45	149466	2036	63337475
Tachycardia	59.57	9.67	479	149032	117677	63221834
Sedation	58.67	9.67	213	149298	38596	63300915
Malignant neoplasm progression	57.57	9.67	65	149446	82056	63257455
Mood altered	57.47	9.67	115	149396	14628	63324883
Therapeutic response unexpected	56.69	9.67	132	149379	18627	63320884
Tic	55.35	9.67	38	149473	1482	63338029
Bradyphrenia	55.29	9.67	75	149436	6905	63332606
Cholecystitis chronic	54.52	9.67	92	149419	10269	63329242
Irritable bowel syndrome	52.74	9.67	70	149441	82342	63257169
Pulseless electrical activity	52.42	9.67	76	149435	7445	63332066
Myocardial depression	52.38	9.67	25	149486	479	63339032
Libido increased	52.26	9.67	35	149476	1310	63338201
Abnormal dreams	52.21	9.67	91	149420	10425	63329086
Depressive symptom	52.08	9.67	56	149455	4046	63335465
Pancytopenia	51.82	9.67	93	149418	96840	63242671
Knee arthroplasty	51.41	9.67	32	149479	54174	63285337
Cerebral vasoconstriction	50.73	9.67	33	149478	1175	63338336
Decorticate posture	50.47	9.67	21	149490	286	63339225
Hyperreflexia	50.45	9.67	66	149445	5868	63333643
Hostility	50.43	9.67	39	149472	1833	63337678
Sinus bradycardia	50.27	9.67	108	149403	14443	63325068
Sinusitis	50.19	9.67	320	149191	226333	63113178
Thrombocytopenia	49.98	9.67	185	149326	150972	63188539
Platelet count decreased	49.90	9.67	126	149385	115996	63223515
Stress cardiomyopathy	49.84	9.67	84	149427	9366	63330145
Alcohol interaction	49.77	9.67	43	149468	2366	63337145
Atrial septal defect	49.66	9.67	71	149440	6867	63332644
Impulsive behaviour	49.37	9.67	36	149475	1547	63337964
Dependence	48.95	9.67	40	149471	2037	63337474
Persistent genital arousal disorder	48.50	9.67	20	149491	266	63339245
Memory impairment	48.45	9.67	415	149096	103843	63235668
Clonus	48.13	9.67	57	149454	4579	63334932
Acute respiratory distress syndrome	47.05	9.67	142	149369	23392	63316119
Renal impairment	47.03	9.67	85	149426	88270	63251241
Eosinophilic pneumonia acute	46.94	9.67	22	149489	404	63339107
Multiple sclerosis	46.81	9.67	145	149366	24227	63315284
Dyspnoea	46.31	9.67	1195	148316	660118	62679393
Anaemia	46.07	9.67	455	149056	292975	63046536
Feeling abnormal	45.90	9.67	543	148968	147849	63191662
Long QT syndrome	45.61	9.67	47	149464	3232	63336279
Mucosal inflammation	45.48	9.67	27	149484	46901	63292610
Exposure during pregnancy	45.42	9.67	563	148948	154984	63184527
Catatonia	44.76	9.67	54	149457	4423	63335088
Speech disorder	44.67	9.67	202	149309	40427	63299084
Accidental death	44.37	9.67	37	149474	1939	63337572
Maternal exposure during breast feeding	43.79	9.67	52	149459	4189	63335322
Red blood cell sedimentation rate increased	43.06	9.67	25	149486	43957	63295554
Blood pressure fluctuation	43.02	9.67	28	149483	46289	63293222
Inappropriate antidiuretic hormone secretion	42.63	9.67	105	149406	15357	63324154
Abortion missed	42.41	9.67	34	149477	1685	63337826
Confusional state	42.36	9.67	787	148724	235593	63103918
Apathy	42.24	9.67	75	149436	8719	63330792
Cerebral microhaemorrhage	42.18	9.67	15	149496	129	63339382
Ventricular fibrillation	42.05	9.67	89	149422	11778	63327733
Morbid thoughts	41.77	9.67	23	149488	600	63338911
Pre-eclampsia	41.46	9.67	76	149435	9057	63330454
Accidental overdose	41.40	9.67	135	149376	23174	63316337
Fear	41.30	9.67	105	149406	15661	63323850
Atrial fibrillation	41.06	9.67	139	149372	116497	63223014
Arthritis	40.91	9.67	138	149373	115783	63223728
Dermatitis atopic	40.51	9.67	78	149433	9646	63329865
Blood hyposmosis	39.60	9.67	10	149501	20	63339491
Maternal drugs affecting foetus	39.53	9.67	55	149456	5187	63334324
Unresponsive to stimuli	39.34	9.67	171	149340	33645	63305866
Agitation neonatal	39.27	9.67	21	149490	516	63338995
Dysarthria	38.78	9.67	201	149310	42510	63297001
Joint range of motion decreased	38.63	9.67	14	149497	32414	63307097
Antipsychotic drug level increased	38.62	9.67	44	149467	3391	63336120
Hyponatraemia	38.45	9.67	418	149093	111482	63228029
Hallucination, visual	38.16	9.67	116	149395	19182	63320329
Urinary incontinence	38.10	9.67	163	149348	31851	63307660
Hypotonia neonatal	38.10	9.67	28	149483	1218	63338293
Major depression	38.02	9.67	68	149443	7950	63331561
Euphoric mood	37.94	9.67	52	149459	4835	63334676
Respiration abnormal	37.85	9.67	60	149451	6357	63333154
Anorgasmia	36.99	9.67	21	149490	582	63338929
Sinus tachycardia	36.51	9.67	133	149378	24135	63315376
Heart sounds	36.51	9.67	25	149486	971	63338540
Stress	36.43	9.67	277	149234	66890	63272621
Inflammation	36.33	9.67	88	149423	82185	63257326
Diarrhoea	36.29	9.67	1349	148162	714017	62625494
Traumatic coma	35.07	9.67	11	149500	61	63339450
Talipes	34.92	9.67	29	149482	1511	63338000
Atrioventricular block first degree	34.90	9.67	62	149449	7211	63332300
Mental disorder	34.82	9.67	137	149374	25782	63313729
Fibromyalgia	34.74	9.67	87	149424	80333	63259178
Blood prolactin increased	34.61	9.67	42	149469	3461	63336050
Cogwheel rigidity	34.44	9.67	32	149479	1938	63337573
Prolonged expiration	34.35	9.67	25	149486	1071	63338440
Myelosuppression	34.29	9.67	7	149504	23696	63315815
Oculogyric crisis	34.11	9.67	30	149481	1691	63337820
Amnesia	34.04	9.67	236	149275	55349	63284162
Maternal exposure during pregnancy	33.78	9.67	343	149168	219719	63119792
Cough	33.62	9.67	486	149025	292257	63047254
Metabolic acidosis	33.52	9.67	201	149310	44868	63294643
Physical assault	33.44	9.67	23	149488	900	63338611
Soft tissue injury	33.15	9.67	29	149482	1623	63337888
Cystostomy	33.15	9.67	11	149500	75	63339436
Cytomegalovirus infection	32.90	9.67	5	149506	20947	63318564
Lethargy	32.66	9.67	235	149276	55772	63283739
Hypertonia	32.52	9.67	47	149464	4590	63334921
Ventricular hypokinesia	32.47	9.67	47	149464	4597	63334914
Blood creatinine increased	32.08	9.67	103	149408	87741	63251770
Bone marrow oedema syndrome	31.91	9.67	9	149502	32	63339479
Cardiac failure	31.53	9.67	106	149405	89036	63250475
Neuropathy peripheral	31.43	9.67	149	149362	113518	63225993
Multiple sclerosis relapse	30.98	9.67	208	149303	48270	63291241
Mental impairment	30.79	9.67	88	149423	14063	63325448
Heart disease congenital	30.58	9.67	25	149486	1274	63338237
Musculoskeletal pain	30.45	9.67	113	149398	92164	63247347
Panic reaction	30.29	9.67	43	149468	4131	63335380
Fatigue	30.07	9.67	1749	147762	886279	62453232
Blood lactic acid decreased	30.06	9.67	12	149499	146	63339365
Breech presentation	29.92	9.67	24	149487	1190	63338321
Psychotic disorder	29.90	9.67	130	149381	25582	63313929
Loss of libido	29.75	9.67	25	149486	1324	63338187
Psoriatic arthropathy	29.60	9.67	113	149398	91407	63248104
Breast discomfort	29.41	9.67	17	149494	488	63339023
Hallucination	29.13	9.67	225	149286	54592	63284919
Sternal fracture	29.02	9.67	31	149480	2223	63337288
Dissociation	28.84	9.67	35	149476	2884	63336627
Depression suicidal	28.80	9.67	28	149483	1795	63337716
Neoplasm progression	28.76	9.67	26	149485	36402	63303109
Herpes zoster	28.52	9.67	99	149412	82363	63257148
Loss of consciousness	28.46	9.67	413	149098	117708	63221803
Hyperthermia	28.29	9.67	65	149446	9091	63330420
Blood lactate dehydrogenase increased	27.50	9.67	10	149501	23106	63316405
Delusion of grandeur	27.38	9.67	13	149498	246	63339265
Drug level increased	27.24	9.67	116	149395	22620	63316891
Drug abuser	27.19	9.67	34	149477	2889	63336622
Alcoholism	27.01	9.67	27	149484	1791	63337720
Thinking abnormal	26.97	9.67	70	149441	10573	63328938
Burning mouth syndrome	26.60	9.67	16	149495	495	63339016
Septic shock	26.57	9.67	75	149436	66554	63272957
Flat affect	26.22	9.67	24	149487	1426	63338085
Pulmonary valve stenosis	26.18	9.67	14	149497	344	63339167
Protein C increased	26.03	9.67	10	149501	109	63339402
Dysphoria	26.00	9.67	44	149467	4922	63334589
Attention-seeking behaviour	25.99	9.67	9	149502	71	63339440
Marital problem	25.97	9.67	11	149500	157	63339354
Persistent foetal circulation	25.82	9.67	12	149499	216	63339295
Concussion	25.72	9.67	63	149448	9181	63330330
Breast enlargement	25.61	9.67	25	149486	1611	63337900
Blood pressure measurement	25.53	9.67	13	149498	288	63339223
Psychomotor retardation	25.37	9.67	38	149473	3832	63335679
Pleural effusion	25.29	9.67	123	149388	93087	63246424
Pulmonary haemosiderosis	25.27	9.67	5	149506	0	63339511
Disinhibition	25.12	9.67	19	149492	864	63338647
Bulimia nervosa	25.09	9.67	15	149496	459	63339052
Affect lability	24.90	9.67	70	149441	11081	63328430
Psychomotor hyperactivity	24.86	9.67	68	149443	10595	63328916
Agoraphobia	24.86	9.67	14	149497	382	63339129
Small for dates baby	24.83	9.67	37	149474	3714	63335797
Posture abnormal	24.75	9.67	29	149482	2303	63337208
Trichotillomania	24.59	9.67	10	149501	128	63339383
Hypomania	24.22	9.67	49	149462	6281	63333230
Poor quality sleep	24.11	9.67	102	149409	19833	63319678
Disorientation	23.85	9.67	167	149344	39285	63300226
Developmental delay	23.85	9.67	23	149488	1460	63338051
Yawning	23.79	9.67	20	149491	1060	63338451
Formication	23.78	9.67	39	149472	4252	63335259
Erythema	23.74	9.67	282	149229	175469	63164042
Prescribed underdose	23.67	9.67	21	149490	29668	63309843
Drug tolerance decreased	23.60	9.67	6	149505	17467	63322044
Hypothermia	23.53	9.67	78	149433	13503	63326008
Vitamin B1 decreased	23.52	9.67	11	149500	201	63339310
Leukocytosis	23.50	9.67	122	149389	25813	63313698
Reduced facial expression	23.50	9.67	26	149485	1940	63337571
Emotional poverty	23.37	9.67	13	149498	346	63339165
Emotional disorder	23.32	9.67	77	149434	13302	63326209
Gallbladder disorder	23.25	9.67	97	149414	18745	63320766
Type 2 diabetes mellitus	23.24	9.67	75	149436	63793	63275718
Bursitis	23.15	9.67	32	149479	37009	63302502
Grip strength decreased	22.78	9.67	12	149499	22275	63317236
Fall	22.61	9.67	1135	148376	391199	62948312
Self esteem decreased	22.58	9.67	16	149495	657	63338854
Drug hypersensitivity	22.56	9.67	558	148953	310129	63029382
White blood cell count decreased	22.51	9.67	214	149297	138890	63200621
Diet failure	22.44	9.67	7	149504	38	63339473
Heart rate	22.38	9.67	8	149503	70	63339441
Bone erosion	22.23	9.67	7	149504	17710	63321801
Gestational diabetes	22.08	9.67	56	149455	8340	63331171
Swollen tongue	22.04	9.67	149	149362	34651	63304860
Pulmonary valve stenosis congenital	21.93	9.67	10	149501	172	63339339
Bone marrow failure	21.84	9.67	22	149489	29268	63310243
Neonatal complications of substance abuse	21.81	9.67	5	149506	5	63339506
Liver disorder	21.72	9.67	60	149451	53627	63285884
Induced abortion failed	21.71	9.67	11	149500	241	63339270
Food interaction	21.58	9.67	17	149494	821	63338690
Lip dry	21.50	9.67	5	149506	15465	63324046
Ventricular arrhythmia	21.49	9.67	35	149476	3793	63335718
Narcolepsy	21.46	9.67	21	149490	1357	63338154
Pulmonary fibrosis	21.44	9.67	38	149473	39771	63299740
CYP3A4 polymorphism	21.43	9.67	8	149503	80	63339431
Haemoglobin decreased	21.39	9.67	229	149282	145256	63194255
Acute kidney injury	21.39	9.67	465	149046	262950	63076561
Sleep-related eating disorder	21.35	9.67	17	149494	834	63338677
Hypotension	21.33	9.67	814	148697	271790	63067721
Somnambulism	21.32	9.67	43	149468	5500	63334011
Dizziness	21.24	9.67	1226	148285	428699	62910812
Weight increased	21.19	9.67	782	148729	260010	63079501
Eating disorder symptom	20.97	9.67	9	149502	133	63339378
Liver function test increased	20.85	9.67	28	149483	32783	63306728
Bruxism	20.85	9.67	33	149478	3492	63336019
Aortic bruit	20.72	9.67	6	149505	24	63339487
Post-traumatic neck syndrome	20.71	9.67	25	149486	2049	63337462
Blood pressure systolic increased	20.68	9.67	51	149460	47346	63292165
Neuroleptic malignant syndrome	20.67	9.67	69	149442	11987	63327524
IIIrd nerve paresis	20.67	9.67	9	149502	138	63339373
Homicidal ideation	20.65	9.67	23	149488	1729	63337782
Eye movement disorder	20.64	9.67	41	149470	5187	63334324
Complication of device insertion	20.46	9.67	51	149460	7513	63331998
Infantile apnoea	20.46	9.67	18	149493	1015	63338496
Electrocardiogram repolarisation abnormality	20.38	9.67	20	149491	1297	63338214
Balance disorder	20.26	9.67	295	149216	84127	63255384
Maternal exposure via partner during pregnancy	20.21	9.67	4	149507	0	63339511
Posterior segment of eye anomaly congenital	20.21	9.67	4	149507	0	63339511
Foetal alcohol syndrome	20.16	9.67	6	149505	27	63339484
Patent ductus arteriosus	20.09	9.67	36	149475	4214	63335297
Device placement issue	20.09	9.67	20	149491	1320	63338191
Dysphemia	20.07	9.67	28	149483	2647	63336864
Incubator therapy	20.02	9.67	7	149504	57	63339454
Borderline personality disorder	19.92	9.67	16	149495	795	63338716
Feeling guilty	19.91	9.67	14	149497	568	63338943
Osteoarthritis	19.87	9.67	137	149374	95206	63244305
Nervousness	19.84	9.67	133	149378	30846	63308665
Brugada syndrome	19.82	9.67	12	149499	376	63339135
Intrusive thoughts	19.78	9.67	10	149501	218	63339293
Tongue biting	19.74	9.67	21	149490	1499	63338012
Ideas of reference	19.70	9.67	8	149503	102	63339409
Peripheral venous disease	19.63	9.67	6	149505	15471	63324040
Adverse event	19.60	9.67	87	149424	67472	63272039
Primitive reflex test positive	19.48	9.67	5	149506	11	63339500
Respiratory disorder neonatal	19.44	9.67	19	149492	1226	63338285
Appetite disorder	19.43	9.67	49	149462	7272	63332239
Pruritus	19.28	9.67	677	148834	360776	62978735
Serum sickness-like reaction	19.17	9.67	13	149498	497	63339014
Bipolar I disorder	19.14	9.67	23	149488	1876	63337635
Procedural hypertension	19.12	9.67	11	149500	313	63339198
Gaze palsy	19.12	9.67	20	149491	1400	63338111
Hypertonic bladder	19.06	9.67	32	149479	3556	63335955
Anhedonia	18.99	9.67	63	149448	10911	63328600
Foetal arrhythmia	18.97	9.67	9	149502	170	63339341
Musculoskeletal stiffness	18.96	9.67	313	149198	184305	63155206
Cholelithiasis	18.92	9.67	172	149339	43753	63295758
Constipation	18.86	9.67	395	149116	224548	63114963
Ventricular tachycardia	18.81	9.67	95	149416	19884	63319627
Neonatal hypoxia	18.81	9.67	14	149497	621	63338890
Drug screen positive	18.80	9.67	32	149479	3597	63335914
Libido decreased	18.62	9.67	27	149484	2645	63336866
Placenta praevia	18.61	9.67	17	149494	1007	63338504
Slow response to stimuli	18.50	9.67	17	149494	1015	63338496
Bradykinesia	18.49	9.67	39	149472	5149	63334362
Ventricular extrasystoles	18.39	9.67	65	149446	11622	63327889
Anterograde amnesia	18.34	9.67	13	149498	534	63338977
Atrioventricular block second degree	18.31	9.67	33	149478	3881	63335630
Gastric bypass	18.30	9.67	22	149489	1795	63337716
Affective disorder	18.30	9.67	43	149468	6103	63333408
Posterior reversible encephalopathy syndrome	18.24	9.67	9	149502	17336	63322175
Sudden onset of sleep	18.21	9.67	13	149498	540	63338971
Cholecystectomy	18.21	9.67	61	149450	10616	63328895
Oppositional defiant disorder	18.20	9.67	6	149505	40	63339471
Hypercalcaemia	18.17	9.67	24	149487	28298	63311213
Spinal shock	18.13	9.67	5	149506	16	63339495
Feeling jittery	18.13	9.67	71	149440	13332	63326179
pH body fluid increased	17.98	9.67	4	149507	3	63339508
Optic ischaemic neuropathy	17.88	9.67	18	149493	1204	63338307
Angle closure glaucoma	17.82	9.67	24	149487	2195	63337316
Hypersomnia	17.82	9.67	87	149424	17968	63321543
Drug eruption	17.72	9.67	25	149486	28669	63310842
Regurgitation	17.67	9.67	21	149490	1693	63337818
Prolonged labour	17.66	9.67	13	149498	567	63338944
Sepsis	17.63	9.67	254	149257	152869	63186642
Supraventricular tachyarrhythmia	17.62	9.67	7	149504	84	63339427
Psoriasis	17.50	9.67	295	149216	86662	63252849
Alcohol use	17.48	9.67	23	149488	2056	63337455
Atelectasis neonatal	17.47	9.67	5	149506	19	63339492
Influenza like illness	17.44	9.67	237	149274	66587	63272924
Binge eating	17.43	9.67	12	149499	470	63339041
Macular degeneration	17.40	9.67	19	149492	24357	63315154
Chronic fatigue syndrome	17.34	9.67	17	149494	1101	63338410
Oesophageal food impaction	17.33	9.67	9	149502	208	63339303
Neonatal respiratory distress	17.10	9.67	11	149500	384	63339127
Electrolyte depletion	17.10	9.67	9	149502	214	63339297
Migraine	17.08	9.67	340	149171	103006	63236505
Prolonged rupture of membranes	17.04	9.67	6	149505	50	63339461
Congenital brain damage	16.98	9.67	4	149507	5	63339506
Hallucinations, mixed	16.86	9.67	36	149475	4793	63334718
Therapy non-responder	16.86	9.67	107	149404	75794	63263717
Bipolar disorder	16.83	9.67	49	149462	7911	63331600
Personality change	16.79	9.67	45	149466	6928	63332583
Toxic epidermal necrolysis	16.74	9.67	21	149490	25313	63314198
Oedema	16.74	9.67	148	149363	97474	63242037
Facet joint syndrome	16.72	9.67	4	149507	12134	63327377
Pre-existing condition improved	16.72	9.67	50	149461	8194	63331317
Neonatal asphyxia	16.70	9.67	10	149501	307	63339204
Inadequate analgesia	16.65	9.67	27	149484	2916	63336595
Energy increased	16.64	9.67	26	149485	2721	63336790
Condition aggravated	16.59	9.67	776	148735	401441	62938070
Polydactyly	16.58	9.67	10	149501	311	63339200
Analgesic drug level increased	16.58	9.67	24	149487	2348	63337163
Dermatillomania	16.54	9.67	8	149503	158	63339353
Agonal rhythm	16.54	9.67	5	149506	24	63339487
Increased appetite	16.41	9.67	55	149456	9575	63329936
Heavy menstrual bleeding	16.38	9.67	84	149427	17689	63321822
Creatinine renal clearance decreased	16.35	9.67	9	149502	16299	63323212
Therapeutic response decreased	16.22	9.67	82	149429	61443	63278068
Foetal monitoring abnormal	16.17	9.67	9	149502	240	63339271
Tachyphrenia	16.13	9.67	18	149493	1356	63338155
Jaundice neonatal	16.12	9.67	15	149496	910	63338601
Acute myopia	16.10	9.67	7	149504	107	63339404
Decreased interest	15.95	9.67	28	149483	3226	63336285
Nystagmus	15.85	9.67	41	149470	6179	63333332
Single umbilical artery	15.74	9.67	9	149502	253	63339258
Dysmorphism	15.71	9.67	23	149488	2273	63337238
Blunted affect	15.71	9.67	9	149502	254	63339257
Phobia	15.68	9.67	10	149501	344	63339167
Hyporesponsive to stimuli	15.68	9.67	16	149495	1088	63338423
Menstruation irregular	15.67	9.67	44	149467	6960	63332551
Tooth hypoplasia	15.65	9.67	6	149505	65	63339446
Alcohol withdrawal syndrome	15.56	9.67	14	149497	813	63338698
Anorexia nervosa	15.49	9.67	9	149502	261	63339250
Mononucleosis syndrome	15.48	9.67	8	149503	183	63339328
Skin ulcer	15.34	9.67	51	149460	42994	63296517
Pulmonary vasculitis	15.32	9.67	7	149504	121	63339390
Anal incontinence	15.29	9.67	68	149443	13508	63326003
Obsessive thoughts	15.24	9.67	12	149499	579	63338932
Staring	15.23	9.67	19	149492	1611	63337900
Panniculitis	15.20	9.67	4	149507	11381	63328130
Osteonecrosis of jaw	15.16	9.67	38	149473	35085	63304426
Abortion spontaneous	15.15	9.67	174	149337	47021	63292490
Tension	15.15	9.67	27	149484	3148	63336363
Umbilical cord around neck	15.09	9.67	8	149503	193	63339318
Psychotic behaviour	15.08	9.67	12	149499	588	63338923
Vertigo	15.06	9.67	211	149300	59676	63279835
Disturbance in sexual arousal	15.01	9.67	7	149504	127	63339384
Cleft palate	14.98	9.67	15	149496	997	63338514
Theft	14.81	9.67	6	149505	76	63339435
Polyneuropathy	14.70	9.67	8	149503	14581	63324930
Pleurothotonus	14.69	9.67	17	149494	1332	63338179
Purple glove syndrome	14.66	9.67	8	149503	205	63339306
Spontaneous haematoma	14.64	9.67	14	149497	879	63338632
Amenorrhoea	14.63	9.67	54	149457	9860	63329651
Feeling drunk	14.60	9.67	31	149480	4111	63335400
Cold agglutinins positive	14.60	9.67	5	149506	38	63339473
Transient aphasia	14.49	9.67	5	149506	39	63339472
Plasma cell mastitis	14.49	9.67	5	149506	39	63339472
Hypoprolactinaemia	14.46	9.67	4	149507	13	63339498
Parkinsonian gait	14.39	9.67	11	149500	508	63339003
Vision blurred	14.39	9.67	300	149211	91624	63247887
Fluid retention	14.38	9.67	82	149429	59604	63279907
Withdrawal catatonia	14.27	9.67	6	149505	84	63339427
Palmar-plantar erythrodysaesthesia syndrome	14.26	9.67	20	149491	22995	63316516
Live birth	14.23	9.67	24	149487	25606	63313905
Negative thoughts	14.20	9.67	14	149497	913	63338598
Liver injury	14.12	9.67	84	149427	60436	63279075
Cardiac output increased	14.08	9.67	8	149503	222	63339289
Sleep paralysis	14.08	9.67	12	149499	648	63338863
Confabulation	14.08	9.67	9	149502	311	63339200
Biliary dyskinesia	14.05	9.67	24	149487	2705	63336806
Coordination abnormal	14.05	9.67	67	149444	13706	63325805
Hypouricaemia	14.04	9.67	7	149504	148	63339363
Microcephaly	14.04	9.67	14	149497	926	63338585
Chemical burn	14.02	9.67	10	149501	415	63339096
Sudden cardiac death	14.01	9.67	21	149490	2119	63337392
Gambling disorder	14.01	9.67	16	149495	1236	63338275
Feeling of despair	13.98	9.67	22	149489	2317	63337194
Cataplexy	13.97	9.67	16	149495	1240	63338271
Social anxiety disorder	13.89	9.67	10	149501	421	63339090
Hypoxic-ischaemic encephalopathy	13.88	9.67	31	149480	4256	63335255
Muscle enzyme increased	13.83	9.67	7	149504	153	63339358
Acute myeloid leukaemia	13.82	9.67	12	149499	17135	63322376
Blood pressure diastolic decreased	13.81	9.67	20	149491	22686	63316825
Swelling face	13.76	9.67	218	149293	63257	63276254
Economic problem	13.74	9.67	20	149491	1966	63337545
Sluggishness	13.71	9.67	35	149476	5234	63334277
Altered state of consciousness	13.65	9.67	104	149407	25126	63314385
Thrombotic microangiopathy	13.56	9.67	4	149507	10557	63328954
Ataxia	13.44	9.67	71	149440	15124	63324387
Pericardial effusion	13.38	9.67	32	149479	30026	63309485
Long QT syndrome congenital	13.38	9.67	6	149505	99	63339412
Basilar migraine	13.31	9.67	5	149506	51	63339460
Metastases to bone	13.29	9.67	18	149493	21001	63318510
Tenosynovitis	13.28	9.67	8	149503	13787	63325724
Neonatal disorder	13.26	9.67	11	149500	572	63338939
Blood pressure diastolic abnormal	13.22	9.67	9	149502	14533	63324978
Craniosynostosis	13.16	9.67	7	149504	170	63339341
Gait disturbance	13.15	9.67	542	148969	182636	63156875
Menopausal symptoms	13.14	9.67	22	149489	2439	63337072
Haematotoxicity	13.09	9.67	3	149508	9373	63330138
Oesophageal adenocarcinoma	13.09	9.67	7	149504	172	63339339
Pregnancy with advanced maternal age	13.09	9.67	3	149508	3	63339508
Floppy infant	13.06	9.67	6	149505	105	63339406
Loss of bladder sensation	13.06	9.67	5	149506	54	63339457
Platelet dysfunction	12.96	9.67	6	149505	107	63339404
Joint hyperextension	12.95	9.67	9	149502	358	63339153
Fear of weight gain	12.93	9.67	4	149507	21	63339490
Duodenal ulcer repair	12.89	9.67	5	149506	56	63339455
Premature labour	12.88	9.67	61	149450	12443	63327068
Amaurosis	12.85	9.67	11	149500	598	63338913
General physical condition abnormal	12.83	9.67	30	149481	4244	63335267
Depersonalisation/derealisation disorder	12.83	9.67	16	149495	1356	63338155
Cytokine release syndrome	12.83	9.67	9	149502	14305	63325206
Oesophageal achalasia	12.82	9.67	10	149501	476	63339035
Post-traumatic stress disorder	12.76	9.67	34	149477	5217	63334294
Blood pressure systolic abnormal	12.56	9.67	8	149503	13378	63326133
Joint effusion	12.51	9.67	13	149498	17047	63322464
Social avoidant behaviour	12.48	9.67	24	149487	2964	63336547
Leukopenia	12.46	9.67	119	149392	77171	63262340
Potentiating drug interaction	12.45	9.67	30	149481	4326	63335185
Brucellosis	12.37	9.67	5	149506	63	63339448
Ventricular septal defect	12.35	9.67	30	149481	4348	63335163
Jaw clicking	12.35	9.67	4	149507	25	63339486
Rhabdomyolysis	12.35	9.67	158	149353	43793	63295718
Hypnopompic hallucination	12.30	9.67	5	149506	64	63339447
Transplant rejection	12.26	9.67	5	149506	10775	63328736
Infantile vomiting	12.20	9.67	6	149505	123	63339388
Respiratory disorder	12.15	9.67	49	149462	39033	63300478
Bradycardia neonatal	12.09	9.67	13	149498	939	63338572
Body height increased	12.09	9.67	5	149506	67	63339444
Medical diet	12.09	9.67	4	149507	27	63339484
Hospitalisation	12.07	9.67	135	149376	84946	63254565
Panic disorder	12.06	9.67	22	149489	2611	63336900
Blood parathyroid hormone decreased	12.05	9.67	4	149507	9787	63329724
Multiple allergies	11.95	9.67	9	149502	13793	63325718
Blood bilirubin increased	11.91	9.67	46	149465	37094	63302417
Adverse drug reaction	11.90	9.67	125	149386	79589	63259922
Blood magnesium decreased	11.90	9.67	62	149449	13136	63326375
Hyperinsulinism	11.88	9.67	3	149508	6	63339505
Renal adenoma	11.88	9.67	3	149508	6	63339505
Carotid arterial embolus	11.88	9.67	3	149508	6	63339505
Bacteraemia	11.86	9.67	14	149497	17334	63322177
Drug use disorder	11.83	9.67	32	149479	4952	63334559
Unmasking of previously unidentified disease	11.82	9.67	13	149498	963	63338548
Extensor plantar response	11.80	9.67	15	149496	1296	63338215
Areflexia	11.77	9.67	24	149487	3094	63336417
Spina bifida occulta	11.57	9.67	3	149508	7	63339504
Peritonitis	11.56	9.67	14	149497	17140	63322371
Personality disorder	11.55	9.67	35	149476	5776	63333735
Substance abuse	11.55	9.67	31	149480	4776	63334735
Antidepressant drug level above therapeutic	11.55	9.67	9	149502	428	63339083
Basal cell carcinoma	11.53	9.67	31	149480	27960	63311551
Coeliac disease	11.53	9.67	8	149503	12789	63326722
Salivary hypersecretion	11.52	9.67	42	149469	7624	63331887
Proteinuria	11.51	9.67	17	149494	19128	63320383
Hypometabolism	11.50	9.67	4	149507	32	63339479
Status migrainosus	11.50	9.67	6	149505	140	63339371
Blood triglycerides increased	11.49	9.67	59	149452	12429	63327082
Pain in extremity	11.47	9.67	651	148860	330835	63008676
Diverticulitis	11.44	9.67	51	149460	39506	63300005
Pulmonary toxicity	11.40	9.67	4	149507	9451	63330060
Acute stress disorder	11.40	9.67	7	149504	225	63339286
Alcohol poisoning	11.40	9.67	18	149493	1901	63337610
Spasmodic dysphonia	11.35	9.67	5	149506	79	63339432
Lymphocytic hypophysitis	11.29	9.67	7	149504	229	63339282
Congenital multiplex arthrogryposis	11.29	9.67	4	149507	34	63339477
Hepatic function abnormal	11.28	9.67	47	149464	37095	63302416
Toxicologic test abnormal	11.25	9.67	11	149500	710	63338801
Urinary retention	11.25	9.67	115	149396	30186	63309325
Hyperkalaemia	11.23	9.67	78	149433	54125	63285386
Hypokalaemia	11.20	9.67	322	149189	103482	63236029
Skin disorder	11.19	9.67	34	149477	29473	63310038
Pregnancy on oral contraceptive	11.18	9.67	13	149498	1024	63338487
Dissociative identity disorder	11.18	9.67	5	149506	82	63339429
Pulmonary valve incompetence	11.17	9.67	15	149496	1368	63338143
Pelvic pain	11.16	9.67	62	149449	13457	63326054
Irregular breathing	11.05	9.67	8	149503	340	63339171
Anticholinergic syndrome	11.04	9.67	20	149491	2362	63337149
Thought insertion	11.02	9.67	3	149508	9	63339502
Tooth demineralisation	11.02	9.67	3	149508	9	63339502
Oedema peripheral	11.01	9.67	351	149160	189160	63150351
Autonomic nervous system imbalance	11.00	9.67	22	149489	2796	63336715
Muscle neoplasm	10.99	9.67	4	149507	37	63339474
Sleep attacks	10.96	9.67	5	149506	86	63339425
Skin necrosis	10.96	9.67	10	149501	13940	63325571
Factitious disorder	10.91	9.67	5	149506	87	63339424
Product deposit	10.87	9.67	7	149504	245	63339266
Gingival discomfort	10.87	9.67	8	149503	349	63339162
Food craving	10.86	9.67	16	149495	1590	63337921
Pulmonary artery stenosis congenital	10.84	9.67	7	149504	246	63339265
Periodic limb movement disorder	10.82	9.67	7	149504	247	63339264
Premature rupture of membranes	10.81	9.67	31	149480	4962	63334549
Gallbladder neoplasm	10.81	9.67	4	149507	39	63339472
Cytopenia	10.79	9.67	7	149504	11594	63327917
Antisocial personality disorder	10.79	9.67	3	149508	10	63339501
Micturition urgency	10.72	9.67	48	149463	9563	63329948
Sensation of blood flow	10.71	9.67	5	149506	91	63339420
Facial paralysis	10.68	9.67	63	149448	13978	63325533
Myasthenic syndrome	10.67	9.67	7	149504	253	63339258
Electrocardiogram QT interval	10.61	9.67	6	149505	165	63339346
Superior mesenteric artery syndrome	10.56	9.67	5	149506	94	63339417
Conduction disorder	10.48	9.67	15	149496	1452	63338059
Apgar score low	10.48	9.67	11	149500	773	63338738
Neutropenic sepsis	10.47	9.67	14	149497	16424	63323087
Lymphatic system neoplasm	10.46	9.67	4	149507	43	63339468
Pyloric stenosis	10.46	9.67	8	149503	370	63339141
Lung disorder	10.40	9.67	95	149416	62166	63277345
Verbal abuse	10.37	9.67	5	149506	98	63339413
Pleural disorder	10.34	9.67	10	149501	637	63338874
Product use in unapproved indication	10.33	9.67	332	149179	178748	63160763
Trismus	10.31	9.67	26	149485	3859	63335652
Ketonuria	10.26	9.67	10	149501	643	63338868
Lactation disorder	10.24	9.67	8	149503	382	63339129
Agranulocytosis	10.23	9.67	28	149483	25106	63314405
Drug ineffective for unapproved indication	10.23	9.67	124	149387	33939	63305572
Hyporeflexia	10.20	9.67	17	149494	1878	63337633
Cardiac output decreased	10.17	9.67	12	149499	960	63338551
Hypersexuality	10.15	9.67	9	149502	513	63338998
Embolism	10.14	9.67	3	149508	7903	63331608
Vaginal haemorrhage	10.05	9.67	104	149407	27383	63312128
Enterocolitis	10.05	9.67	3	149508	7855	63331656
Premature delivery	10.04	9.67	37	149474	30244	63309267
Road traffic accident	10	9.67	131	149380	36501	63303010
Electrocardiogram T wave inversion	9.98	9.67	24	149487	3457	63336054
Pulmonary embolism	9.98	9.67	352	149159	116332	63223179
Psychiatric symptom	9.96	9.67	31	149480	5192	63334319
Death of relative	9.95	9.67	7	149504	284	63339227
Enuresis	9.94	9.67	20	149491	2553	63336958
Bradycardia	9.89	9.67	234	149277	72993	63266518
Alpha 1 globulin increased	9.85	9.67	5	149506	110	63339401
Carbon monoxide poisoning	9.82	9.67	6	149505	191	63339320
Hypertrophic scar	9.82	9.67	3	149508	15	63339496
Spinal fusion acquired	9.82	9.67	3	149508	15	63339496
Enthesopathy	9.79	9.67	4	149507	8610	63330901
Job dissatisfaction	9.78	9.67	4	149507	52	63339459
Hypnagogic hallucination	9.77	9.67	6	149505	193	63339318
Uterine hypertonus	9.76	9.67	7	149504	293	63339218
Grandiosity	9.76	9.67	7	149504	293	63339218
Blood potassium decreased	9.74	9.67	146	149365	41880	63297631
Menstruation normal	9.74	9.67	6	149505	194	63339317
Head deformity	9.73	9.67	5	149506	113	63339398
Heart rate decreased	9.72	9.67	65	149446	45495	63294016
Antidepressant discontinuation syndrome	9.71	9.67	4	149507	53	63339458
Breath sounds abnormal	9.70	9.67	7	149504	10966	63328545
Labour induction	9.69	9.67	5	149506	114	63339397

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Serotonin syndrome	998.34	11.13	554	62608	19379	34874390
Suicidal ideation	461.07	11.13	460	62702	39928	34853841
Completed suicide	428.15	11.13	691	62471	97477	34796292
Toxicity to various agents	421.04	11.13	1038	62124	199324	34694445
Suicide attempt	414.52	11.13	428	62734	38688	34855081
Intentional overdose	350.36	11.13	413	62749	43261	34850508
Drug interaction	325.23	11.13	1020	62142	224926	34668843
Obsessive-compulsive disorder	321.00	11.13	170	62992	5394	34888375
Akathisia	286.38	11.13	180	62982	7929	34885840
Euphoric mood	218.95	11.13	133	63029	5508	34888261
Antipsychotic drug level below therapeutic	203.35	11.13	97	63065	2450	34891319
Aggression	187.08	11.13	287	62875	38677	34855092
Therapeutic product effect variable	185.37	11.13	90	63072	2366	34891403
Disinhibition	184.47	11.13	98	63064	3128	34890641
Anxiety	178.06	11.13	486	62676	98942	34794827
Agitation	172.64	11.13	344	62818	57055	34836714
Drug abuse	161.37	11.13	468	62694	98628	34795141
Overdose	155.00	11.13	437	62725	90622	34803147
Increased appetite	154.19	11.13	119	63043	7310	34886459
Drug withdrawal syndrome	136.92	11.13	174	62988	19660	34874109
Depression	132.34	11.13	431	62731	96667	34797102
Homicide	127.16	11.13	52	63110	897	34892872
Irritability	121.48	11.13	184	62978	24506	34869263
Febrile neutropenia	120.90	11.13	48	63114	136801	34756968
Obesity	117.02	11.13	130	63032	12748	34881021
Drug dependence	105.96	11.13	171	62991	24046	34869723
Electrocardiogram QT prolonged	102.76	11.13	228	62934	40724	34853045
Tardive dyskinesia	95.29	11.13	81	63081	5709	34888060
Pneumonia	89.69	11.13	345	62817	362282	34531487
Depressed mood	89.46	11.13	140	63022	19177	34874592
Anaemia	83.84	11.13	186	62976	233149	34660620
Psychotic disorder	83.82	11.13	155	63007	24297	34869472
Sedation	83.40	11.13	142	63020	20864	34872905
Intentional self-injury	82.94	11.13	113	63049	13658	34880111
Pyrexia	81.55	11.13	318	62844	332695	34561074
Exposure during pregnancy	80.84	11.13	90	63072	8844	34884925
Mania	79.58	11.13	92	63070	9419	34884350
Malignant neoplasm progression	79.17	11.13	30	63132	88016	34805753
Sepsis	76.56	11.13	114	63048	166447	34727322
Tremor	74.34	11.13	321	62841	82266	34811503
Paranoia	74.16	11.13	100	63062	11968	34881801
Disease progression	72.02	11.13	54	63108	108023	34785746
Weight increased	69.96	11.13	343	62819	92690	34801079
Choreoathetosis	68.49	11.13	35	63127	1029	34892740
Suicidal behaviour	67.79	11.13	39	63123	1458	34892311
Tic	63.55	11.13	42	63120	2016	34891753
Platelet count decreased	63.10	11.13	74	63088	119643	34774126
Poisoning	62.81	11.13	93	63069	12133	34881636
Thrombocytopenia	62.47	11.13	117	63045	156130	34737639
Hyperreflexia	61.43	11.13	49	63113	3157	34890612
Sexual dysfunction	61.38	11.13	66	63096	6237	34887532
Victim of child abuse	61.15	11.13	31	63131	896	34892873
Anger	60.48	11.13	90	63072	11794	34881975
General physical health deterioration	59.69	11.13	87	63075	128182	34765587
Abnormal behaviour	59.25	11.13	136	63026	24833	34868936
Drug withdrawal syndrome neonatal	58.27	11.13	50	63112	3569	34890200
Intentional product misuse	58.07	11.13	198	62964	45413	34848356
Extrapyramidal disorder	56.40	11.13	91	63071	12789	34880980
Homicidal ideation	55.73	11.13	43	63119	2639	34891130
Social avoidant behaviour	54.20	11.13	45	63117	3069	34890700
Hallucination, auditory	53.28	11.13	85	63077	11832	34881937
Dyskinesia	53.09	11.13	122	63040	22291	34871478
Muscle twitching	49.58	11.13	76	63086	10222	34883547
Disturbance in attention	49.53	11.13	130	63032	25815	34867954
Diarrhoea	49.33	11.13	459	62703	389453	34504316
Prescribed overdose	49.06	11.13	77	63085	10570	34883199
Synaesthesia	47.86	11.13	9	63153	0	34893769
Withdrawal syndrome	47.86	11.13	83	63079	12372	34881397
Antipsychotic drug level increased	47.71	11.13	46	63116	3819	34889950
Electrocardiogram QRS complex prolonged	47.22	11.13	51	63111	4843	34888926
Parasomnia	46.94	11.13	20	63142	384	34893385
Epidural lipomatosis	46.50	11.13	27	63135	1027	34892742
Renal impairment	46.05	11.13	62	63100	94451	34799318
Respiratory depression	45.96	11.13	95	63067	16150	34877619
Dyslipidaemia	45.93	11.13	62	63100	7426	34886343
Insomnia	45.17	11.13	332	62830	103575	34790194
Pancytopenia	44.78	11.13	64	63098	95093	34798676
Major depression	44.74	11.13	48	63114	4524	34889245
Haemoglobin decreased	44.33	11.13	95	63067	120677	34773092
Bipolar disorder	44.04	11.13	43	63119	3626	34890143
Rhabdomyolysis	43.39	11.13	240	62922	67923	34825846
Torsade de pointes	43.17	11.13	59	63103	7150	34886619
Mental disorder	43.10	11.13	89	63073	15120	34878649
Infection	41.94	11.13	62	63100	90853	34802916
Nightmare	41.71	11.13	85	63077	14306	34879463
Drug abuser	41.34	11.13	43	63119	3911	34889858
Atrial fibrillation	41.11	11.13	101	63061	122292	34771477
Asphyxia	41.02	11.13	56	63106	6779	34886990
Rash	40.72	11.13	236	62926	222516	34671253
Juvenile idiopathic arthritis	40.70	11.13	31	63131	1866	34891903
Tremor neonatal	40.51	11.13	18	63144	384	34893385
Panic attack	40.42	11.13	66	63096	9366	34884403
Myoclonus	40.36	11.13	85	63077	14640	34879129
Generalised tonic-clonic seizure	40.32	11.13	106	63056	21068	34872701
Depersonalisation/derealisation disorder	39.58	11.13	20	63142	574	34893195
Leukaemia	39.30	11.13	45	63117	4558	34889211
Acute kidney injury	38.52	11.13	359	62803	304629	34589140
Visceral congestion	38.47	11.13	20	63142	610	34893159
Hepatic function abnormal	38.41	11.13	16	63146	44347	34849422
Seizure	38.38	11.13	322	62840	104535	34789234
Hyperhidrosis	38.27	11.13	251	62911	75441	34818328
Neutropenia	38.05	11.13	150	63012	156628	34737141
Maternal drugs affecting foetus	37.70	11.13	41	63121	3924	34889845
Chorea	37.05	11.13	24	63138	1113	34892656
Psychomotor hyperactivity	36.81	11.13	64	63098	9558	34884211
Mucosal inflammation	36.69	11.13	12	63150	38610	34855159
Apathy	35.99	11.13	53	63109	6879	34886890
Neuroleptic malignant syndrome	35.40	11.13	91	63071	17843	34875926
Abnormal dreams	35.18	11.13	55	63107	7523	34886246
Thinking abnormal	34.91	11.13	49	63113	6088	34887681
Delusion	34.71	11.13	73	63089	12562	34881207
Off label use	34.58	11.13	542	62620	418982	34474787
Clonus	34.46	11.13	33	63129	2717	34891052
Abnormal sleep-related event	34.22	11.13	17	63145	470	34893299
Stomatitis	34.21	11.13	17	63145	42497	34851272
Cholinergic syndrome	34.03	11.13	18	63144	569	34893200
Blood prolactin increased	33.94	11.13	27	63135	1733	34892036
Drug level increased	33.63	11.13	102	63060	21994	34871775
Priapism	33.17	11.13	43	63119	4951	34888818
Restless legs syndrome	32.53	11.13	56	63106	8298	34885471
Somnolence	32.43	11.13	325	62837	110791	34782978
Mood swings	32.13	11.13	54	63108	7847	34885922
Product complaint	31.99	11.13	46	63116	5844	34887925
Serum ferritin abnormal	31.54	11.13	13	63149	229	34893540
Schizoaffective disorder	31.40	11.13	23	63139	1304	34892465
Nervousness	31.39	11.13	70	63092	12536	34881233
Septic shock	31.20	11.13	51	63111	71783	34821986
Self-medication	31.18	11.13	31	63131	2672	34891097
Mast cell activation syndrome	31.13	11.13	13	63149	237	34893532
Cytomegalovirus infection	31.01	11.13	5	63157	26130	34867639
Obsessive-compulsive symptom	30.91	11.13	11	63151	127	34893642
Oral discharge	30.75	11.13	11	63151	129	34893640
Child abuse	30.29	11.13	15	63147	412	34893357
Rheumatoid arthritis	29.71	11.13	16	63146	38222	34855547
Persistent foetal circulation	29.44	11.13	14	63148	351	34893418
Hallucination	29.28	11.13	176	62986	51322	34842447
Derealisation	28.23	11.13	16	63146	581	34893188
Sinus tachycardia	28.19	11.13	82	63080	17278	34876491
Bruxism	27.99	11.13	24	63138	1711	34892058
COVID-19	27.62	11.13	62	63100	77488	34816281
Sleep disorder	27.58	11.13	122	63040	31566	34862203
Huntington's disease	27.50	11.13	8	63154	45	34893724
Libido decreased	27.47	11.13	38	63124	4658	34889111
Impulsive behaviour	27.19	11.13	26	63136	2136	34891633
Antidepressant drug level increased	27.17	11.13	10	63152	128	34893641
Social anxiety disorder	26.94	11.13	13	63149	337	34893432
Dissociation	26.88	11.13	23	63139	1635	34892134
Muscle rigidity	26.86	11.13	59	63103	10459	34883310
Interstitial lung disease	26.84	11.13	48	63114	65234	34828535
Affective disorder	26.59	11.13	36	63126	4324	34889445
Memory impairment	26.54	11.13	151	63011	43167	34850602
Cardiac failure	26.36	11.13	81	63081	91167	34802602
Congenital aortic valve stenosis	25.91	11.13	10	63152	147	34893622
Neonatal disorder	25.78	11.13	17	63145	813	34892956
Oculogyric crisis	25.71	11.13	22	63140	1564	34892205
Dystonia	25.64	11.13	59	63103	10786	34882983
Neuropathy peripheral	25.43	11.13	72	63090	83191	34810578
Alcoholism	25.34	11.13	29	63133	2936	34890833
Coma	25.26	11.13	155	63007	45523	34848246
Cyanosis neonatal	25.15	11.13	12	63150	303	34893466
Cardiac arrest	25.10	11.13	275	62887	95884	34797885
Hyperkalaemia	25.10	11.13	55	63107	69334	34824435
Product substitution issue	25.07	11.13	56	63106	10039	34883730
Lethargy	24.96	11.13	143	63019	40979	34852790
Mood altered	24.91	11.13	52	63110	8900	34884869
Gambling disorder	24.84	11.13	22	63140	1638	34892131
Foetal exposure during pregnancy	24.79	11.13	135	63027	37966	34855803
Pleural effusion	24.55	11.13	71	63091	81475	34812294
Renal failure	24.53	11.13	137	63025	130420	34763349
Dreamy state	24.42	11.13	6	63156	15	34893754
Accidental death	24.41	11.13	26	63136	2430	34891339
Physical deconditioning	24.41	11.13	20	63142	1339	34892430
Violence-related symptom	24.37	11.13	14	63148	522	34893247
Feeling jittery	24.33	11.13	33	63129	3970	34889799
Initial insomnia	24.11	11.13	29	63133	3095	34890674
Accommodation disorder	23.72	11.13	11	63151	260	34893509
Restlessness	23.63	11.13	100	63062	25382	34868387
Ascites	23.23	11.13	30	63132	46541	34847228
Herpes zoster	23.13	11.13	17	63145	34382	34859387
Hostility	23.07	11.13	16	63146	832	34892937
Pulmonary embolism	22.96	11.13	84	63078	89662	34804107
Respiratory arrest	22.93	11.13	106	63056	27937	34865832
Tearfulness	22.65	11.13	26	63136	2641	34891128
Neonatal respiratory distress syndrome	22.63	11.13	32	63130	4002	34889767
Prostate cancer	22.53	11.13	23	63139	39626	34854143
Alcohol poisoning	22.42	11.13	30	63132	3563	34890206
Poisoning deliberate	22.34	11.13	46	63116	7798	34885971
Parkinsonism	22.33	11.13	47	63115	8091	34885678
Antisocial behaviour	22.24	11.13	12	63150	395	34893374
Disseminated intravascular coagulation	22.13	11.13	6	63156	21810	34871959
Eye movement disorder	22.07	11.13	32	63130	4095	34889674
Poor quality sleep	21.86	11.13	47	63115	8209	34885560
Emotional disorder	21.84	11.13	38	63124	5678	34888091
Infusion related reaction	21.82	11.13	39	63123	53018	34840751
Erythema	21.47	11.13	85	63077	88695	34805074
Serum serotonin decreased	21.27	11.13	4	63158	0	34893769
Mydriasis	21.27	11.13	43	63119	7194	34886575
Porphyria acute	21.14	11.13	11	63151	336	34893433
Arthralgia	21.04	11.13	201	62961	169840	34723929
Vasoplegia syndrome	20.88	11.13	21	63141	1835	34891934
White blood cell count decreased	20.86	11.13	95	63067	95350	34798419
Neoplasm progression	20.82	11.13	8	63154	23292	34870477
Blunted affect	20.76	11.13	11	63151	349	34893420
Peripheral swelling	20.67	11.13	70	63092	76471	34817298
Vascular stenosis	20.65	11.13	9	63153	183	34893586
Hyperdynamic left ventricle	20.56	11.13	9	63153	185	34893584
Pain	20.50	11.13	254	62908	204421	34689348
Flat affect	20.50	11.13	15	63147	849	34892920
Cytokine release syndrome	20.21	11.13	8	63154	22869	34870900
Obsessive thoughts	19.97	11.13	14	63148	741	34893028
Somnambulism	19.70	11.13	26	63136	3046	34890723
Loss of employment	19.61	11.13	12	63150	503	34893266
Compulsive shopping	19.57	11.13	11	63151	393	34893376
Hypersomnia	19.56	11.13	58	63104	12349	34881420
Treatment failure	19.49	11.13	34	63128	46663	34847106
Negative thoughts	19.41	11.13	13	63149	638	34893131
Agitation neonatal	19.41	11.13	16	63146	1080	34892689
Tachyphrenia	19.35	11.13	17	63145	1252	34892517
Schizophrenia	19.24	11.13	46	63116	8620	34885149
Yawning	19.05	11.13	12	63150	530	34893239
Cataplexy	18.91	11.13	10	63152	316	34893453
Joint swelling	18.87	11.13	51	63111	59839	34833930
Self-injurious ideation	18.85	11.13	19	63143	1665	34892104
Compulsive hoarding	18.78	11.13	5	63157	19	34893750
Cough	18.77	11.13	177	62985	149963	34743806
Hypoglycaemia neonatal	18.67	11.13	20	63142	1881	34891888
Tumour lysis syndrome	18.66	11.13	4	63158	17055	34876714
Compulsions	18.66	11.13	9	63153	233	34893536
Metabolic acidosis	18.63	11.13	139	63023	43541	34850228
Loss of libido	18.58	11.13	23	63139	2529	34891240
Renal ischaemia	18.52	11.13	12	63150	557	34893212
Retinal phototoxicity	18.51	11.13	4	63158	4	34893765
Congenital aortic valve incompetence	18.48	11.13	8	63154	160	34893609
Hypomania	18.37	11.13	22	63140	2337	34891432
Alcohol use	18.33	11.13	26	63136	3262	34890507
Lymphocyte count decreased	18.26	11.13	9	63153	22613	34871156
Gastrointestinal haemorrhage	18.20	11.13	90	63072	88387	34805382
Premature baby	18.16	11.13	77	63085	19556	34874213
Neutrophil count decreased	18.07	11.13	41	63121	51063	34842706
Anaphylactic reaction	18.05	11.13	19	63143	32282	34861487
Dissociative disorder	18.05	11.13	11	63151	458	34893311
Pituitary tumour benign	18.03	11.13	14	63148	867	34892902
Dyspnoea	18.02	11.13	531	62631	376251	34517518
Hyperprolactinaemia	17.85	11.13	18	63144	1578	34892191
Chronic actinic dermatitis	17.68	11.13	5	63157	25	34893744
Haematochezia	17.56	11.13	36	63126	46498	34847271
Small for dates baby	17.54	11.13	28	63134	3899	34889870
Multiple organ dysfunction syndrome	17.46	11.13	75	63087	76491	34817278
Coagulation factor VII level decreased	17.26	11.13	7	63155	118	34893651
Pneumocystis jirovecii pneumonia	17.23	11.13	7	63155	19703	34874066
Colitis	17.15	11.13	26	63136	37724	34856045
Urinary tract discomfort	17.10	11.13	7	63155	121	34893648
C-reactive protein increased	17.10	11.13	46	63116	54052	34839717
Hypersexuality	16.99	11.13	17	63145	1476	34892293
Myocardial infarction	16.78	11.13	139	63023	120946	34772823
Secondary hypogonadism	16.77	11.13	9	63153	293	34893476
Selective mutism	16.72	11.13	6	63156	71	34893698
Tourette's disorder	16.65	11.13	6	63156	72	34893697
Renal artery thrombosis	16.42	11.13	9	63153	306	34893463
Palmar-plantar erythrodysaesthesia syndrome	16.34	11.13	5	63157	16790	34876979
Antipsychotic drug level decreased	16.27	11.13	14	63148	1003	34892766
Feeling guilty	16.21	11.13	9	63153	314	34893455
Pupil fixed	16.04	11.13	18	63144	1783	34891986
Basilar migraine	16.01	11.13	4	63158	11	34893758
Intentional product use issue	15.95	11.13	55	63107	59761	34834008
Muscle necrosis	15.83	11.13	13	63149	873	34892896
Congenital hand malformation	15.66	11.13	11	63151	584	34893185
Feeling abnormal	15.65	11.13	179	62983	63056	34830713
Dysphoria	15.57	11.13	20	63142	2282	34891487
Transposition of the great vessels	15.53	11.13	10	63152	459	34893310
Bone marrow failure	15.48	11.13	18	63144	29235	34864534
Coma uraemic	15.46	11.13	5	63157	42	34893727
Autonomic nervous system imbalance	15.46	11.13	21	63141	2530	34891239
Pruritus	15.43	11.13	173	62989	141808	34751961
Phobia	15.43	11.13	7	63155	157	34893612
Erectile dysfunction	15.42	11.13	76	63086	20561	34873208
Attention deficit hyperactivity disorder	15.41	11.13	21	63141	2538	34891231
Treatment noncompliance	15.31	11.13	95	63067	28005	34865764
Decreased interest	15.18	11.13	20	63142	2340	34891429
Thrombosis	15.13	11.13	44	63118	50414	34843355
Spina bifida	15.09	11.13	9	63153	360	34893409
Hyperbilirubinaemia neonatal	15.08	11.13	12	63150	770	34892999
Creatinine urine decreased	15.06	11.13	5	63157	46	34893723
Condition aggravated	15.03	11.13	454	62708	191742	34702027
Bipolar I disorder	15.02	11.13	12	63150	775	34892994
Bronchopulmonary aspergillosis	14.93	11.13	4	63158	14655	34879114
COVID-19 pneumonia	14.88	11.13	6	63156	16961	34876808
Tension	14.87	11.13	19	63143	2156	34891613
Exposure via ingestion	14.83	11.13	19	63143	2162	34891607
Product prescribing error	14.75	11.13	81	63081	22846	34870923
Logorrhoea	14.74	11.13	20	63142	2406	34891363
Liver disorder	14.72	11.13	23	63139	32974	34860795
Cerebrovascular stenosis	14.70	11.13	6	63156	103	34893666
Blood lactate dehydrogenase increased	14.65	11.13	12	63150	22978	34870791
Haemodynamic instability	14.52	11.13	44	63118	9479	34884290
Eye colour change	14.51	11.13	8	63154	275	34893494
Miosis	14.49	11.13	44	63118	9491	34884278
Respiratory failure	14.43	11.13	126	63036	108446	34785323
Post 5-alpha-reductase inhibitor syndrome	14.34	11.13	6	63156	110	34893659
Blood glucose fluctuation	14.31	11.13	26	63136	4018	34889751
Dysphemia	14.31	11.13	16	63146	1579	34892190
Full blood count abnormal	14.22	11.13	8	63154	18660	34875109
Tongue injury	14.19	11.13	6	63156	113	34893656
Alpha 2 globulin decreased	14.14	11.13	4	63158	20	34893749
Otosalpingitis	14.14	11.13	4	63158	20	34893749
Blood luteinising hormone decreased	14.14	11.13	6	63156	114	34893655
Abdominal distension	14.14	11.13	56	63106	58436	34835333
Hospitalisation	14.06	11.13	54	63108	56848	34836921
Sex hormone binding globulin decreased	13.98	11.13	4	63158	21	34893748
Free androgen index decreased	13.98	11.13	4	63158	21	34893748
Crying	13.98	11.13	32	63130	5830	34887939
Pyloric stenosis	13.92	11.13	12	63150	862	34892907
Blood creatine phosphokinase MB	13.88	11.13	3	63159	3	34893766
Delayed sleep phase	13.88	11.13	3	63159	3	34893766
Androgen insensitivity syndrome	13.83	11.13	4	63158	22	34893747
Viral acanthoma	13.83	11.13	4	63158	22	34893747
Binge eating	13.81	11.13	6	63156	121	34893648
Disorientation	13.80	11.13	105	63057	33083	34860686
Death	13.74	11.13	584	62578	397465	34496304
Suspected suicide	13.70	11.13	28	63134	4720	34889049
Mutism	13.67	11.13	12	63150	883	34892886
Productive cough	13.64	11.13	30	63132	37783	34855986
Oedema	13.63	11.13	40	63122	45701	34848068
Blood creatinine increased	13.63	11.13	108	63054	94868	34798901
Staring	13.63	11.13	15	63147	1455	34892314
Marital problem	13.58	11.13	5	63157	64	34893705
Testicular microlithiasis	13.53	11.13	4	63158	24	34893745
Feeling drunk	13.47	11.13	17	63145	1906	34891863
Blood triglycerides increased	13.46	11.13	56	63106	14103	34879666
Ear discomfort	13.43	11.13	20	63142	2622	34891147
Dehydroepiandrosterone decreased	13.39	11.13	4	63158	25	34893744
Urine calcium/creatinine ratio increased	13.39	11.13	4	63158	25	34893744
Appendicitis	13.37	11.13	5	63157	14802	34878967
Blood bilirubin increased	13.32	11.13	31	63131	38265	34855504
Economic problem	13.28	11.13	14	63148	1293	34892476
Salivary hypersecretion	13.24	11.13	40	63122	8604	34885165
Cognitive disorder	13.20	11.13	93	63069	28600	34865169
Hypertonia neonatal	13.15	11.13	9	63153	458	34893311
Confusional state	13.06	11.13	347	62815	143813	34749956
Hypothalamic pituitary adrenal axis suppression	12.97	11.13	6	63156	141	34893628
Hypogonadism male	12.93	11.13	8	63154	342	34893427
Candida infection	12.92	11.13	8	63154	17707	34876062
Fear	12.90	11.13	45	63117	10431	34883338
Speech disorder	12.86	11.13	85	63077	25601	34868168
Arnold-Chiari malformation	12.85	11.13	8	63154	346	34893423
Hepatic failure	12.79	11.13	27	63135	34504	34859265
Arthropathy	12.74	11.13	18	63144	26889	34866880
Alpha globulin increased	12.67	11.13	3	63159	6	34893763
Wrong drug	12.57	11.13	5	63157	80	34893689
Heart rate abnormal	12.53	11.13	16	63146	1815	34891954
Nausea	12.50	11.13	495	62667	339413	34554356
Cerebral infarction	12.38	11.13	19	63143	27436	34866333
Haemophagocytic lymphohistiocytosis	12.37	11.13	4	63158	12969	34880800
Bone marrow oedema	12.30	11.13	10	63152	662	34893107
Drooling	12.30	11.13	22	63140	3360	34890409
Myelodysplastic syndrome	12.27	11.13	10	63152	19198	34874571
Testis cancer	12.25	11.13	14	63148	1415	34892354
Cyclothymic disorder	12.13	11.13	5	63157	88	34893681
Atrial septal defect	12.08	11.13	35	63127	7357	34886412
Thought insertion	12.07	11.13	3	63159	8	34893761
Drug reaction with eosinophilia and systemic symptoms	12.07	11.13	26	63136	32986	34860783
Locked-in syndrome	12.01	11.13	7	63155	268	34893501
Self esteem decreased	11.99	11.13	9	63153	530	34893239
Panic disorder	11.98	11.13	13	63149	1241	34892528
Bradycardia	11.91	11.13	197	62965	75221	34818548
Sleep apnoea syndrome	11.89	11.13	70	63092	20251	34873518
Panic reaction	11.89	11.13	14	63148	1461	34892308
Mental status changes	11.88	11.13	113	63049	37970	34855799
Neutropenic sepsis	11.86	11.13	5	63157	13762	34880007
Psychiatric symptom	11.70	11.13	22	63140	3491	34890278
Abnormal loss of weight	11.66	11.13	24	63138	4066	34889703
Chronic kidney disease	11.60	11.13	37	63125	41173	34852596
Therapeutic product effect incomplete	11.59	11.13	141	63021	50400	34843369
Carbon monoxide poisoning	11.55	11.13	5	63157	100	34893669
Ankyloglossia congenital	11.52	11.13	7	63155	290	34893479
Urinary retention	11.48	11.13	108	63054	36180	34857589
Water intoxication	11.47	11.13	8	63154	420	34893349
Drug intolerance	11.45	11.13	62	63100	59508	34834261
Mixed delusion	11.41	11.13	4	63158	44	34893725
Dyspnoea exertional	11.40	11.13	40	63122	43239	34850530
Retrograde ejaculation	11.38	11.13	8	63154	425	34893344
Multiple sclerosis	11.38	11.13	32	63130	6613	34887156
Coordination abnormal	11.36	11.13	35	63127	7609	34886160
Genital anaesthesia	11.35	11.13	3	63159	11	34893758
Thyroxine free abnormal	11.35	11.13	3	63159	11	34893758
Cardiac failure congestive	11.35	11.13	96	63066	83174	34810595
Cortisol increased	11.33	11.13	6	63156	190	34893579
Therapeutic response unexpected	11.24	11.13	41	63121	9716	34884053
Gastric hypomotility	11.20	11.13	5	63157	108	34893661
Urine phosphorus decreased	11.18	11.13	4	63158	47	34893722

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	2158.64	9.71	2636	167475	243131	79331146
Serotonin syndrome	1420.23	9.71	991	169120	44036	79530241
Toxicity to various agents	1297.17	9.71	2806	167305	418734	79155543
Intentional overdose	1288.86	9.71	1348	168763	104612	79469665
Suicidal ideation	1055.30	9.71	1041	169070	75299	79498978
Suicide attempt	785.31	9.71	926	169185	82006	79492271
Drug interaction	776.93	9.71	2290	167821	412893	79161384
Drug abuse	668.05	9.71	1224	168887	161467	79412810
Intentional self-injury	566.76	9.71	504	169607	31915	79542362
Electrocardiogram QT prolonged	487.22	9.71	768	169343	89618	79484659
Overdose	405.25	9.71	1079	169032	183127	79391150
Anxiety	353.89	9.71	1250	168861	247262	79327015
Tremor	351.75	9.71	974	169137	169109	79405168
Agitation	340.07	9.71	694	169417	99021	79475256
Depression	301.30	9.71	1082	169029	215708	79358569
Drug withdrawal syndrome	297.90	9.71	369	169742	34349	79539928
Respiratory arrest	290.82	9.71	475	169636	57075	79517202
Poisoning	286.37	9.71	310	169801	24962	79549315
Cardiac arrest	277.70	9.71	903	169208	171193	79403084
Cardio-respiratory arrest	270.93	9.71	667	169444	107843	79466434
Synovitis	260.85	9.71	15	170096	150719	79423558
Akathisia	257.63	9.71	219	169892	13040	79561237
Febrile neutropenia	240.21	9.71	96	170015	230903	79343374
Torsade de pointes	222.50	9.71	239	169872	19073	79555204
Irritability	222.10	9.71	350	169761	40794	79533483
Aggression	219.73	9.71	392	169719	50566	79523711
Contraindicated product administered	213.33	9.71	39	170072	157499	79416778
Withdrawal syndrome	202.93	9.71	268	169843	26586	79547691
Hand deformity	197.86	9.71	5	170106	103914	79470363
Joint swelling	197.05	9.71	195	169916	288451	79285826
Infusion related reaction	191.41	9.71	128	169983	230109	79344168
Depressed mood	187.68	9.71	356	169755	48124	79526153
Suicidal behaviour	187.41	9.71	105	170006	3142	79571135
Obsessive-compulsive disorder	185.64	9.71	130	169981	5797	79568480
Somnolence	184.25	9.71	1000	169111	237981	79336296
Reversible cerebral vasoconstriction syndrome	182.29	9.71	101	170010	2956	79571321
Poisoning deliberate	179.28	9.71	211	169900	18617	79555660
Systemic lupus erythematosus	170.61	9.71	27	170084	121122	79453155
Pericarditis	167.04	9.71	15	170096	104221	79470056
Rheumatoid arthritis	162.65	9.71	124	169987	208346	79365931
Pneumonia	159.32	9.71	796	169315	659450	78914827
Respiratory depression	158.84	9.71	242	169869	27388	79546889
Tardive dyskinesia	158.73	9.71	151	169960	10420	79563857
Drug intolerance	156.67	9.71	200	169911	263919	79310358
Mania	151.70	9.71	191	169920	18069	79556208
Coma	151.42	9.71	516	169595	100133	79474144
Drug dependence	143.94	9.71	288	169823	40481	79533796
Rash	141.33	9.71	694	169417	577664	78996613
Disturbance in attention	140.45	9.71	325	169786	50476	79523801
Infection	140.29	9.71	186	169925	241526	79332751
Seizure	139.99	9.71	782	169329	188052	79386225
Sopor	139.81	9.71	252	169859	32758	79541519
Treatment failure	134.78	9.71	100	170011	170386	79403891
Peripheral swelling	134.69	9.71	230	169881	269387	79304890
Electrocardiogram QRS complex prolonged	133.55	9.71	139	169972	10694	79563583
Wound	131.40	9.71	42	170069	116137	79458140
General physical health deterioration	131	9.71	242	169869	274996	79299281
Anaemia	130.63	9.71	498	169613	444517	79129760
Mydriasis	130.10	9.71	174	169937	17469	79556808
Panic attack	129.29	9.71	205	169906	24011	79550266
Nightmare	128.64	9.71	212	169899	25649	79548628
Pyrexia	128.64	9.71	884	169227	677825	78896452
Arthropathy	128.63	9.71	113	169998	176998	79397279
Intentional product misuse	117.84	9.71	458	169653	94707	79479570
Swelling	117.54	9.71	175	169936	216536	79357741
Generalised tonic-clonic seizure	116.02	9.71	276	169835	43634	79530643
Helicobacter infection	114.51	9.71	9	170102	69695	79504582
Malignant neoplasm progression	113.78	9.71	75	170036	135915	79438362
Muscle twitching	111.25	9.71	194	169917	24570	79549707
Homicide	110.77	9.71	53	170058	1133	79573144
Rheumatoid factor positive	109.84	9.71	4	170107	59835	79514442
Abnormal behaviour	109.59	9.71	241	169870	36180	79538097
Thrombocytopenia	108.69	9.71	254	169857	265005	79309272
Arthralgia	108.13	9.71	745	169366	571058	79003219
Disease progression	106.81	9.71	142	169969	184220	79390057
Euphoric mood	105.94	9.71	105	170006	7621	79566656
Muscle rigidity	105.72	9.71	168	169943	19714	79554563
Crying	105.45	9.71	182	169929	22861	79551416
Extrapyramidal disorder	104.93	9.71	180	169931	22499	79551778
Off label use	104.89	9.71	1337	168774	905878	78668399
Platelet count decreased	104.78	9.71	158	169953	194506	79379771
Hepatic enzyme increased	103.42	9.71	143	169968	182467	79391810
Alopecia	102.62	9.71	212	169899	231143	79343134
Neutropenia	102.19	9.71	296	169815	287414	79286863
Pancytopenia	101.91	9.71	122	169989	165623	79408654
Therapeutic product effect decreased	101.41	9.71	120	169991	163743	79410534
Dyskinesia	97.98	9.71	262	169849	44511	79529766
Dystonia	97.90	9.71	169	169942	21230	79553047
Restless legs syndrome	97.64	9.71	163	169948	19929	79554348
Sedation	96.25	9.71	286	169825	51609	79522668
Paranoia	96.25	9.71	159	169952	19273	79555004
Galactorrhoea	96.02	9.71	72	170039	3574	79570703
Myoclonus	95.97	9.71	194	169917	27466	79546811
Duodenal ulcer perforation	94.93	9.71	14	170097	66197	79508080
Stomatitis	94.58	9.71	104	170007	146653	79427624
Glossodynia	93.42	9.71	52	170059	103285	79470992
Hyperreflexia	90.02	9.71	100	170011	8285	79565992
Abdominal discomfort	88.26	9.71	259	169852	250468	79323809
Depressed level of consciousness	88.02	9.71	424	169687	96228	79478049
Tic	87.75	9.71	63	170048	2923	79571354
Self-injurious ideation	87.36	9.71	68	170043	3570	79570707
Anger	87.12	9.71	142	169969	17020	79557257
Coma scale abnormal	85.53	9.71	99	170012	8579	79565698
Hallucination, auditory	85.12	9.71	156	169955	20537	79553740
Renal impairment	84.00	9.71	129	169982	157654	79416623
Hyperhidrosis	83.76	9.71	582	169529	150910	79423367
Restlessness	82.24	9.71	252	169859	46240	79528037
Nasopharyngitis	81.78	9.71	273	169838	253608	79320669
Clonus	81.16	9.71	86	170025	6754	79567523
Sepsis	79.92	9.71	300	169811	269128	79305149
C-reactive protein increased	79.28	9.71	95	170016	128932	79445345
Disinhibition	79.08	9.71	56	170055	2542	79571735
Folliculitis	78.73	9.71	12	170099	55368	79518909
Psychotic disorder	77.56	9.71	229	169882	41173	79533104
Bezoar	77.36	9.71	56	170055	2632	79571645
Acute kidney injury	76.79	9.71	723	169388	518681	79055596
Mucosal inflammation	75.93	9.71	33	170078	75547	79498730
Tearfulness	75.30	9.71	78	170033	5967	79568310
Miosis	75.27	9.71	127	169984	15662	79558615
Atrial fibrillation	75.14	9.71	197	169914	197689	79376588
Parkinsonism	74.60	9.71	130	169981	16454	79557823
Abnormal dreams	74.31	9.71	106	170005	11306	79562971
Blister	73.37	9.71	88	170023	119388	79454889
Sleep disorder due to general medical condition, insomnia type	73.33	9.71	5	170106	43551	79530726
Diarrhoea	72.05	9.71	1385	168726	879104	78695173
Mood swings	72.04	9.71	142	169969	19738	79554539
Lower respiratory tract infection	71.35	9.71	103	170008	129117	79445160
Intentional product use issue	71.20	9.71	135	169976	151977	79422300
Drug ineffective	70.74	9.71	1762	168349	1079151	78495126
Muscle injury	70.24	9.71	10	170101	48551	79525726
C-reactive protein abnormal	69.86	9.71	10	170101	48357	79525920
Impulsive behaviour	69.19	9.71	54	170057	2846	79571431
Antipsychotic drug level increased	69.10	9.71	74	170037	5883	79568394
Product substitution issue	69.00	9.71	141	169970	20115	79554162
Accidental death	67.69	9.71	63	170048	4228	79570049
Impaired healing	65.97	9.71	54	170057	87601	79486676
Mental disorder	65.31	9.71	180	169931	31122	79543155
Mobility decreased	63.96	9.71	101	170010	122074	79452203
Discomfort	63.74	9.71	106	170005	125511	79448766
Cytomegalovirus infection	63.54	9.71	8	170103	42636	79531641
Insomnia	61.98	9.71	797	169314	244373	79329904
Drug abuser	61.62	9.71	70	170041	5943	79568334
Cardiac failure	61.21	9.71	151	169960	154691	79419586
Hypersensitivity	60.28	9.71	321	169790	261918	79312359
Hostility	59.46	9.71	45	170066	2265	79572012
Mood altered	59.34	9.71	123	169988	17724	79556553
Myelosuppression	58.98	9.71	8	170103	40288	79533989
Product complaint	57.92	9.71	103	170008	13246	79561031
Sinus bradycardia	57.53	9.71	150	169961	25097	79549180
Apathy	57.42	9.71	101	170010	12876	79561401
Homicidal ideation	56.95	9.71	52	170059	3405	79570872
Social avoidant behaviour	56.19	9.71	60	170051	4754	79569523
Emotional distress	55.82	9.71	200	169911	39769	79534508
Dissociation	55.78	9.71	55	170056	3966	79570311
Victim of child abuse	55.50	9.71	31	170080	922	79573355
Choreoathetosis	55.24	9.71	37	170074	1533	79572744
Septic shock	54.86	9.71	112	169999	122689	79451588
Cholecystitis chronic	54.45	9.71	85	170026	9821	79564456
Drug level increased	54.18	9.71	197	169914	39454	79534823
Confusional state	54.08	9.71	966	169145	317031	79257246
Myocardial depression	53.58	9.71	25	170086	504	79573773
Sinus tachycardia	53.53	9.71	187	169924	36721	79537556
Pain	53.29	9.71	1121	168990	702681	78871596
Hallucination	53.15	9.71	339	169772	85406	79488871
Psychomotor hyperactivity	52.40	9.71	113	169998	16736	79557541
Blood prolactin increased	52.21	9.71	53	170058	3958	79570319
Neuroleptic malignant syndrome	52.16	9.71	153	169958	27406	79546871
Libido increased	51.55	9.71	39	170072	1962	79572315
Speech disorder	51.11	9.71	241	169870	54204	79520073
Blood creatinine increased	51.10	9.71	165	169946	154892	79419385
Decorticate posture	50.29	9.71	21	170090	321	79573956
Increased appetite	50.15	9.71	91	170020	11887	79562390
Feeling abnormal	49.70	9.71	539	169572	158660	79415617
Dyspnoea	49.39	9.71	1422	168689	855603	78718674
Nervousness	49.07	9.71	170	169941	33245	79541032
Thinking abnormal	48.89	9.71	95	170016	13066	79561211
Stress cardiomyopathy	48.24	9.71	86	170025	11080	79563197
Haemoglobin decreased	48.24	9.71	277	169834	221842	79352435
Suspected suicide	47.69	9.71	83	170028	10493	79563784
Memory impairment	47.61	9.71	404	169707	111330	79462947
Neuropathy peripheral	47.52	9.71	149	169962	141156	79433121
Fear	47.43	9.71	128	169983	21858	79552419
Persistent genital arousal disorder	47.27	9.71	19	170092	262	79574015
Hyperprolactinaemia	47.18	9.71	54	170057	4622	79569655
Tachycardia	47.08	9.71	583	169528	177185	79397092
Dependence	47.04	9.71	40	170071	2382	79571895
Inappropriate antidiuretic hormone secretion	46.88	9.71	143	169968	26170	79548107
Hepatic function abnormal	46.87	9.71	52	170059	73055	79501222
Multiple sclerosis	46.35	9.71	128	169983	22154	79552123
Pleural effusion	46.20	9.71	157	169954	145105	79429172
Oculogyric crisis	45.91	9.71	43	170068	2909	79571368
Herpes zoster	45.88	9.71	80	170031	93003	79481274
Antipsychotic drug level below therapeutic	45.55	9.71	30	170081	1208	79573069
Gastrointestinal disorder	45.35	9.71	123	169988	122082	79452195
Product use issue	44.85	9.71	263	169848	209559	79364718
Long QT syndrome	44.32	9.71	59	170052	5896	79568381
Cough	43.86	9.71	536	169575	366253	79208024
Morbid thoughts	43.76	9.71	25	170086	777	79573500
Bradyphrenia	43.49	9.71	80	170031	10560	79563717
Parasomnia	43.25	9.71	22	170089	539	79573738
Arthritis	43.11	9.71	115	169996	114765	79459512
Erythema	43.02	9.71	289	169822	223001	79351276
Alcoholism	42.75	9.71	46	170065	3677	79570600
Neoplasm progression	42.54	9.71	29	170082	51653	79522624
Ill-defined disorder	42.07	9.71	47	170064	65828	79508449
Synaesthesia	41.22	9.71	8	170103	0	79574277
Major depression	41.18	9.71	71	170040	8909	79565368
Epidural lipomatosis	40.96	9.71	28	170083	1200	79573077
Blood hyposmosis	40.92	9.71	10	170101	19	79574258
Cerebral vasoconstriction	40.89	9.71	30	170081	1440	79572837
Physical assault	40.62	9.71	31	170080	1580	79572697
Poor quality sleep	40.03	9.71	123	169988	22599	79551678
Bruxism	39.79	9.71	46	170065	3980	79570297
Blood pressure fluctuation	39.59	9.71	51	170060	67094	79507183
Rhabdomyolysis	39.35	9.71	364	169747	102767	79471510
Drug hypersensitivity	39.15	9.71	428	169683	298488	79275789
Hyperkalaemia	38.90	9.71	120	169991	114278	79459999
Catatonia	38.55	9.71	68	170043	8688	79565589
Atrioventricular block first degree	37.96	9.71	83	170028	12408	79561869
Blood lactate dehydrogenase increased	37.94	9.71	18	170093	39152	79535125
Alcohol poisoning	37.79	9.71	49	170062	4772	79569505
Libido decreased	36.99	9.71	51	170060	5270	79569007
Heart sounds	36.98	9.71	24	170087	942	79573335
Eye movement disorder	36.29	9.71	63	170048	7948	79566329
Yawning	36.03	9.71	27	170084	1339	79572938
Anorgasmia	35.80	9.71	26	170085	1228	79573049
White blood cell count decreased	35.62	9.71	245	169866	188043	79386234
Obsessive-compulsive symptom	35.57	9.71	14	170097	182	79574095
Ascites	35.40	9.71	67	170044	75495	79498782
Cogwheel rigidity	35.18	9.71	38	170073	3050	79571227
Red blood cell sedimentation rate increased	34.94	9.71	28	170083	45914	79528363
Feeling guilty	34.30	9.71	22	170089	846	79573431
Bone marrow failure	34.27	9.71	35	170076	51072	79523205
Prostate cancer	34.25	9.71	14	170097	33254	79541023
Unresponsive to stimuli	34.22	9.71	220	169891	55568	79518709
Flat affect	34.21	9.71	31	170080	2010	79572267
Cytokine release syndrome	34.17	9.71	17	170094	35981	79538296
Huntington's disease	33.91	9.71	8	170103	12	79574265
Marital problem	33.76	9.71	14	170097	210	79574067
Soft tissue injury	33.74	9.71	29	170082	1752	79572525
Traumatic coma	33.71	9.71	10	170101	50	79574227
Derealisation	33.60	9.71	28	170083	1621	79572656
Inflammation	33.57	9.71	96	170015	93657	79480620
Musculoskeletal stiffness	33.46	9.71	227	169884	174781	79399496
Emotional disorder	33.31	9.71	86	170025	14301	79559976
Affective disorder	33.31	9.71	62	170049	8257	79566020
Reduced facial expression	33.23	9.71	35	170076	2730	79571547
Bipolar I disorder	33.09	9.71	31	170080	2098	79572179
Panic reaction	32.86	9.71	45	170066	4620	79569657
Bipolar disorder	32.84	9.71	59	170052	7648	79566629
Accidental overdose	32.73	9.71	169	169942	39412	79534865
Delusion	32.72	9.71	107	170004	20316	79553961
Violence-related symptom	32.59	9.71	20	170091	711	79573566
Lethargy	32.57	9.71	290	169821	81002	79493275
Hip arthroplasty	32.29	9.71	18	170093	35738	79538539
Hallucination, visual	32.28	9.71	147	169964	32582	79541695
Therapeutic product effect incomplete	32.18	9.71	174	169937	141471	79432806
Pulseless electrical activity	32.13	9.71	84	170027	14076	79560201
Metabolic acidosis	31.84	9.71	292	169819	82237	79492040
Bone marrow oedema syndrome	31.58	9.71	9	170102	38	79574239
Abnormal sleep-related event	31.39	9.71	21	170090	868	79573409
Multiple sclerosis relapse	31.36	9.71	188	169923	46345	79527932
Asphyxia	31.31	9.71	74	170037	11646	79562631
Respiration abnormal	31.13	9.71	58	170053	7730	79566547
Prolonged expiration	31.05	9.71	24	170087	1247	79573030
Staring	30.93	9.71	33	170078	2612	79571665
Mental impairment	30.74	9.71	100	170011	18936	79555341
Therapeutic product effect variable	30.74	9.71	29	170082	1980	79572297
Liver disorder	30.70	9.71	68	170043	72349	79501928
Dysarthria	30.13	9.71	247	169864	67375	79506902
Weight increased	29.86	9.71	789	169322	276597	79297680
Cystostomy	29.51	9.71	10	170101	82	79574195
Dysphoria	29.40	9.71	43	170068	4691	79569586
Irritable bowel syndrome	29.32	9.71	55	170056	62186	79512091
Social anxiety disorder	29.03	9.71	17	170094	554	79573723
Obsessive thoughts	29.02	9.71	22	170089	1110	79573167
Negative thoughts	29.02	9.71	24	170087	1375	79572902
Sinusitis	28.86	9.71	272	169839	195229	79379048
Tension	28.81	9.71	41	170070	4363	79569914
Hypomania	28.69	9.71	55	170056	7489	79566788
Hypersomnia	28.47	9.71	111	170000	22975	79551302
Depressive symptom	28.43	9.71	50	170061	6373	79567904
Multiple organ dysfunction syndrome	28.27	9.71	146	169965	120100	79454177
Borderline personality disorder	28.26	9.71	20	170091	907	79573370
Blood bilirubin increased	28.24	9.71	62	170049	66170	79508107
Dysphemia	28.23	9.71	36	170075	3448	79570829
Basilar migraine	28.17	9.71	9	170102	60	79574217
Self-medication	28.16	9.71	44	170067	5088	79569189
Breast discomfort	28.03	9.71	15	170096	409	79573868
Tachyphrenia	28.02	9.71	28	170083	2052	79572225
Amnesia	27.92	9.71	230	169881	62827	79511450
Visceral congestion	27.70	9.71	20	170091	936	79573341
Migraine	27.65	9.71	297	169814	87196	79487081
Aspergillus infection	27.58	9.71	4	170107	19157	79555120
Neutrophil count decreased	27.58	9.71	105	170006	93854	79480423
Complication of device insertion	27.55	9.71	49	170062	6301	79567976
Carbon monoxide poisoning	27.42	9.71	13	170098	272	79574005
Eosinophilic pneumonia acute	27.41	9.71	21	170090	1077	79573200
Thrombotic microangiopathy	27.27	9.71	5	170106	20164	79554113
Antidepressant drug level increased	27.13	9.71	15	170096	437	79573840
Loss of libido	27.08	9.71	31	170080	2654	79571623
Obesity	27.01	9.71	147	169964	34978	79539299
Hyponatraemia	26.98	9.71	531	169580	177317	79396960
Initial insomnia	26.90	9.71	51	170060	6887	79567390
Depersonalisation/derealisation disorder	26.82	9.71	26	170085	1836	79572441
Influenza like illness	26.80	9.71	252	169859	71455	79502822
Musculoskeletal pain	26.54	9.71	120	169991	102234	79472043
Tumour lysis syndrome	26.45	9.71	9	170102	23930	79550347
Urinary incontinence	26.12	9.71	163	169948	40746	79533531
Formication	26.09	9.71	42	170069	4981	79569296
Somnambulism	25.93	9.71	45	170066	5676	79568601
Transplant rejection	25.89	9.71	5	170106	19432	79554845
Oxygen saturation decreased	25.86	9.71	165	169946	128882	79445395
Blunted affect	25.81	9.71	15	170096	482	79573795
Joint range of motion decreased	25.67	9.71	20	170091	33262	79541015
Oedema	25.48	9.71	150	169961	119430	79454847
Palmar-plantar erythrodysaesthesia syndrome	25.44	9.71	20	170091	33114	79541163
Coordination abnormal	25.35	9.71	88	170023	17224	79557053
Heart rate decreased	25.17	9.71	72	170039	70244	79504033
Sternal fracture	25.16	9.71	29	170082	2501	79571776
Decreased interest	25.05	9.71	35	170076	3662	79570615
Psoriatic arthropathy	24.99	9.71	84	170027	77915	79496362
Bacteraemia	24.97	9.71	20	170091	32804	79541473
Treatment noncompliance	24.97	9.71	194	169917	52074	79522203
Attention deficit hyperactivity disorder	24.96	9.71	33	170078	3276	79571001
Disorientation	24.66	9.71	223	169888	62553	79511724
Self esteem decreased	24.65	9.71	19	170092	983	79573294
Swollen tongue	24.36	9.71	165	169946	42405	79531872
Blood lactic acid decreased	24.36	9.71	12	170099	274	79574003
Foetal arrhythmia	24.34	9.71	8	170103	59	79574218
Knee arthroplasty	24.33	9.71	34	170077	43214	79531063
Burning mouth syndrome	24.32	9.71	15	170096	538	79573739
Jaundice neonatal	24.30	9.71	10	170101	147	79574130
Alcohol interaction	24.29	9.71	40	170071	4834	79569443
Foetal exposure during pregnancy	24.25	9.71	44	170067	5746	79568531
Drug screen positive	24.04	9.71	45	170066	6018	79568259
Loss of consciousness	24.00	9.71	497	169614	167446	79406831
Protein C increased	23.98	9.71	9	170102	102	79574175
Priapism	23.85	9.71	38	170073	4467	79569810
Posture abnormal	23.84	9.71	35	170076	3831	79570446
Anterograde amnesia	23.63	9.71	16	170095	675	79573602
Device placement issue	23.58	9.71	20	170091	1187	79573090
Polyneuropathy	23.54	9.71	11	170100	24140	79550137
Blood pressure diastolic decreased	23.50	9.71	18	170093	30198	79544079
Compulsive shopping	23.48	9.71	17	170094	799	79573478
Sleep-related eating disorder	23.15	9.71	16	170095	698	79573579
Serum serotonin decreased	23.15	9.71	6	170105	16	79574261
Diet failure	23.12	9.71	7	170104	38	79574239
Ventricular hypokinesia	23.09	9.71	57	170054	9222	79565055
Hypertonia	23.06	9.71	49	170062	7183	79567094
Acute respiratory distress syndrome	22.99	9.71	167	169944	43900	79530377
Haematotoxicity	22.91	9.71	3	170108	15516	79558761
Grip strength decreased	22.85	9.71	9	170102	21860	79552417
Hyporesponsive to stimuli	22.58	9.71	25	170086	2063	79572214
Trichotillomania	22.46	9.71	10	170101	180	79574097
Serum sickness-like reaction	22.42	9.71	15	170096	620	79573657
Disseminated intravascular coagulation	22.42	9.71	26	170085	35816	79538461
Child abuse	22.41	9.71	13	170098	416	79573861
Bulimia nervosa	22.34	9.71	11	170100	251	79574026
Therapeutic response unexpected	22.28	9.71	93	170018	19853	79554424
Fibromyalgia	22.22	9.71	67	170044	64273	79510004
Oral discharge	22.10	9.71	11	170100	257	79574020
Pneumocystis jirovecii pneumonia	22.10	9.71	22	170089	32486	79541791
Alcohol use	21.89	9.71	38	170073	4793	79569484
Sexual dysfunction	21.82	9.71	50	170061	7713	79566564
Blood pressure measurement	21.76	9.71	13	170098	440	79573837
Autonomic nervous system imbalance	21.75	9.71	37	170074	4593	79569684
Respiratory disorder	21.69	9.71	39	170072	44817	79529460
Gastrointestinal haemorrhage	21.59	9.71	206	169905	147513	79426764
Blood pressure systolic increased	21.56	9.71	72	170039	66914	79507363
Sluggishness	21.50	9.71	45	170066	6527	79567750
COVID-19 pneumonia	21.42	9.71	18	170093	28831	79545446
Analgesic drug level increased	21.40	9.71	30	170081	3148	79571129
Bursitis	21.36	9.71	27	170084	35817	79538460
Panic disorder	21.28	9.71	29	170082	2963	79571314
Exposure via ingestion	21.27	9.71	39	170072	5135	79569142
Hospitalisation	21.27	9.71	116	169995	94120	79480157
Chorea	21.22	9.71	26	170085	2391	79571886
Cholinergic syndrome	21.21	9.71	18	170093	1069	79573208
Personality disorder	21.19	9.71	43	170068	6103	79568174
Stress	21.01	9.71	261	169850	79351	79494926
Single umbilical artery	21.00	9.71	5	170106	8	79574269
Economic problem	20.88	9.71	25	170086	2245	79572032
Pruritus	20.85	9.71	662	169449	393986	79180291
Post-traumatic neck syndrome	20.82	9.71	24	170087	2070	79572207
Colitis	20.82	9.71	83	170028	73224	79501053
Dreamy state	20.81	9.71	7	170104	56	79574221
Oedema peripheral	20.76	9.71	396	169715	251892	79322385
Pathogen resistance	20.63	9.71	3	170108	14339	79559938
Agitation neonatal	20.61	9.71	4	170107	0	79574277
Binge eating	20.36	9.71	13	170098	496	79573781
Hypoalbuminaemia	20.30	9.71	10	170101	21287	79552990
Ideas of reference	20.27	9.71	9	170102	161	79574116
Heart rate	20.19	9.71	8	170103	106	79574171
Loss of personal independence in daily activities	20.13	9.71	132	169979	102448	79471829
Patent ductus arteriosus	20.12	9.71	8	170103	107	79574170
Hyperthermia	20.07	9.71	84	170027	17953	79556324
Hallucinations, mixed	20.01	9.71	45	170066	6854	79567423
Serum ferritin abnormal	19.96	9.71	12	170099	411	79573866
Thought insertion	19.91	9.71	6	170105	32	79574245
Appetite disorder	19.74	9.71	48	170063	7691	79566586
Graft versus host disease	19.73	9.71	4	170107	15022	79559255
Haematochezia	19.71	9.71	108	170003	87537	79486740
Drug eruption	19.67	9.71	40	170071	43895	79530382
Genital anaesthesia	19.67	9.71	5	170106	12	79574265
Osteonecrosis of jaw	19.66	9.71	39	170072	43187	79531090
Phobia	19.62	9.71	12	170099	424	79573853
Feeling of despair	19.55	9.71	27	170084	2794	79571483
Vision blurred	19.51	9.71	326	169785	105572	79468705
Breath sounds abnormal	19.50	9.71	5	170106	15979	79558298
CYP3A4 polymorphism	19.43	9.71	7	170104	70	79574207
Pulmonary haemosiderosis	19.38	9.71	5	170106	13	79574264
Cataplexy	19.33	9.71	16	170095	918	79573359
Bronchopulmonary aspergillosis	19.04	9.71	12	170099	22282	79551995
Hypercalcaemia	18.96	9.71	33	170078	38397	79535880
IIIrd nerve paresis	18.95	9.71	9	170102	189	79574088
Breast enlargement	18.89	9.71	20	170091	1569	79572708
Amenorrhoea	18.87	9.71	47	170064	7645	79566632
Bladder cancer	18.87	9.71	9	170102	19517	79554760
Liver function test increased	18.86	9.71	35	170076	39738	79534539
Agoraphobia	18.86	9.71	13	170098	565	79573712
Proteinuria	18.84	9.71	25	170086	32477	79541800
Enterocolitis	18.77	9.71	4	170107	14508	79559769
Mental status changes	18.75	9.71	222	169889	66737	79507540
Tenosynovitis	18.72	9.71	5	170106	15549	79558728
Tubulointerstitial nephritis	18.71	9.71	33	170078	38202	79536075
Psychomotor retardation	18.69	9.71	41	170070	6143	79568134
Feeling drunk	18.68	9.71	35	170076	4684	79569593
Anhedonia	18.67	9.71	72	170039	14826	79559451
Induced abortion failed	18.62	9.71	9	170102	197	79574080
Accommodation disorder	18.46	9.71	13	170098	585	79573692
Juvenile idiopathic arthritis	18.45	9.71	35	170076	4728	79569549
Depression suicidal	18.44	9.71	31	170080	3811	79570466
Angle closure glaucoma	18.44	9.71	27	170084	2949	79571328
Anaphylactic reaction	18.40	9.71	104	170007	83639	79490638
Urinary retention	18.24	9.71	193	169918	56437	79517840
Dermatitis atopic	18.24	9.71	55	170056	10001	79564276
Concussion	18.21	9.71	53	170058	9450	79564827
Pseudomonas infection	18.20	9.71	11	170100	20892	79553385
Blood urea increased	18.18	9.71	49	170062	48741	79525536
Gambling disorder	18.13	9.71	22	170089	2004	79572273
Oesophageal food impaction	18.10	9.71	11	170100	384	79573893
Dermatillomania	18.05	9.71	9	170102	211	79574066
Bradycardia	18.02	9.71	397	169714	135160	79439117
Retinal phototoxicity	17.85	9.71	4	170107	4	79574273
Prescribed underdose	17.83	9.71	22	170089	29492	79544785
Resting tremor	17.83	9.71	19	170092	1502	79572775
Agranulocytosis	17.71	9.71	44	170067	44986	79529291
Gallbladder disorder	17.70	9.71	85	170026	19255	79555022
Neutropenic sepsis	17.62	9.71	19	170092	27045	79547232
Posterior reversible encephalopathy syndrome	17.62	9.71	18	170093	26263	79548014
Ventricular arrhythmia	17.62	9.71	50	170061	8790	79565487
Chronic actinic dermatitis	17.56	9.71	5	170106	21	79574256
Drooling	17.55	9.71	39	170072	5895	79568382
Incubator therapy	17.52	9.71	6	170105	51	79574226
Pupil fixed	17.42	9.71	29	170082	3537	79570740
Neonatal seizure	17.38	9.71	4	170107	5	79574272
Cytopenia	17.37	9.71	11	170100	20372	79553905
Diverticulitis	17.21	9.71	46	170065	45890	79528387
Pituitary tumour benign	16.88	9.71	24	170087	2552	79571725
Constipation	16.88	9.71	467	169644	282583	79291694
Myelodysplastic syndrome	16.87	9.71	24	170087	30277	79544000
Dehydroepiandrosterone decreased	16.86	9.71	5	170106	25	79574252
Peritonitis	16.83	9.71	21	170090	28015	79546262
Narcolepsy	16.75	9.71	17	170094	1269	79573008
Blood uric acid increased	16.65	9.71	4	170107	13356	79560921
Sleep disorder	16.61	9.71	266	169845	85411	79488866
Blood pressure systolic abnormal	16.59	9.71	8	170103	17239	79557038
Cholecystectomy	16.56	9.71	51	170060	9381	79564896
Salivary hypersecretion	16.42	9.71	67	170044	14157	79560120
Supraventricular tachyarrhythmia	16.42	9.71	7	170104	113	79574164
Balance disorder	16.30	9.71	299	169812	98558	79475719
Fatigue	16.28	9.71	1736	168375	927991	78646286
Hypersexuality	16.28	9.71	19	170092	1661	79572616
Cardiac failure congestive	16.27	9.71	210	169901	142192	79432085
Product use in unapproved indication	16.26	9.71	408	169703	249951	79324326
Secondary hypogonadism	16.21	9.71	10	170101	359	79573918
Acute myopia	16.20	9.71	7	170104	117	79574160
Electrocardiogram repolarisation abnormality	16.17	9.71	22	170089	2245	79572032
Foetal monitoring abnormal	16.11	9.71	8	170103	186	79574091
Basal cell carcinoma	15.92	9.71	35	170076	37340	79536937
Vaginal haemorrhage	15.90	9.71	90	170021	21727	79552550
Confabulation	15.77	9.71	11	170100	487	79573790
Myocardial infarction	15.76	9.71	287	169824	183842	79390435
Haemophagocytic lymphohistiocytosis	15.76	9.71	14	170097	21823	79552454
Cytomegalovirus viraemia	15.66	9.71	4	170107	12817	79561460
Thrombosis	15.61	9.71	110	170001	83990	79490287
Logorrhoea	15.60	9.71	31	170080	4334	79569943
Eating disorder	15.50	9.71	86	170025	20611	79553666
Sleep paralysis	15.48	9.71	12	170099	626	79573651
Cerebral infarction	15.46	9.71	48	170063	45628	79528649
Selective mutism	15.46	9.71	6	170105	75	79574202
Sudden onset of sleep	15.38	9.71	12	170099	632	79573645
Hypoplastic left heart syndrome	15.35	9.71	4	170107	11	79574266
Spinal shock	15.32	9.71	5	170106	36	79574241
Pneumothorax	15.21	9.71	23	170088	28300	79545977
Large intestine perforation	15.21	9.71	6	170105	14561	79559716
Creatinine renal clearance decreased	15.19	9.71	11	170100	18991	79555286
Fluid retention	15.17	9.71	87	170024	69722	79504555
Cellulitis	15.13	9.71	154	169957	108906	79465371
Energy increased	15.12	9.71	26	170085	3256	79571021
Parkinsonian gait	15.11	9.71	14	170097	934	79573343
Tourette's disorder	15.11	9.71	6	170105	80	79574197
Nystagmus	15.07	9.71	51	170060	9853	79564424
Lip dry	15.06	9.71	7	170104	15411	79558866
Slow response to stimuli	15.01	9.71	19	170092	1806	79572471
Skin ulcer	14.94	9.71	62	170049	54088	79520189
Therapy change	14.89	9.71	42	170069	7357	79566920
Osteoarthritis	14.87	9.71	117	169994	87192	79487085
Facet joint syndrome	14.86	9.71	3	170108	11299	79562978
Panniculitis	14.85	9.71	4	170107	12367	79561910
Gastric bypass	14.81	9.71	16	170095	1285	79572992
Acute myeloid leukaemia	14.80	9.71	27	170084	30858	79543419
Menstruation irregular	14.78	9.71	33	170078	5003	79569274
Decreased appetite	14.74	9.71	589	169522	341829	79232448
Blood magnesium decreased	14.70	9.71	72	170039	16440	79557837
Pericardial effusion	14.67	9.71	50	170061	46187	79528090
Device expulsion	14.65	9.71	100	170011	25761	79548516
Maternal exposure during pregnancy	14.64	9.71	204	169907	136334	79437943
Joint hyperextension	14.61	9.71	9	170102	322	79573955
Autism spectrum disorder	14.59	9.71	15	170096	1137	79573140
Vitamin B1 decreased	14.56	9.71	11	170100	552	79573725
Coma uraemic	14.54	9.71	5	170106	43	79574234
Pregnancy on oral contraceptive	14.49	9.71	13	170098	832	79573445
Diffuse large B-cell lymphoma	14.44	9.71	4	170107	12145	79562132
Feeling jittery	14.44	9.71	60	170051	12781	79561496
Enuresis	14.42	9.71	25	170086	3151	79571126
Dyslipidaemia	14.40	9.71	56	170055	11577	79562700
Atrial septal defect	14.24	9.71	19	170092	1903	79572374
Pain in extremity	14.23	9.71	634	169477	363904	79210373
Atrioventricular block second degree	14.22	9.71	41	170070	7271	79567006
Appendicitis	14.22	9.71	14	170097	20780	79553497
Mast cell activation syndrome	14.21	9.71	12	170099	708	79573569
Antisocial behaviour	14.19	9.71	12	170099	709	79573568
Post 5-alpha-reductase inhibitor syndrome	14.18	9.71	6	170105	95	79574182
Disturbance in sexual arousal	14.17	9.71	8	170103	243	79574034
Micturition urgency	14.16	9.71	59	170052	12582	79561695
Swelling face	14.15	9.71	222	169889	70990	79503287
Death of relative	14.08	9.71	8	170103	246	79574031
Klebsiella infection	14.07	9.71	8	170103	15712	79558565
Drug-induced liver injury	14.04	9.71	83	170028	66034	79508243
Anorexia nervosa	14.02	9.71	8	170103	248	79574029
Hypnopompic hallucination	14.01	9.71	6	170105	98	79574179
Cold agglutinins positive	13.97	9.71	5	170106	49	79574228
Dizziness	13.96	9.71	1304	168807	525137	79049140
Gestational diabetes	13.94	9.71	37	170074	6256	79568021
Locked-in syndrome	13.93	9.71	12	170099	727	79573550
Menopausal symptoms	13.92	9.71	19	170092	1944	79572333
Metastases to lung	13.90	9.71	11	170100	18152	79556125
Prolonged rupture of membranes	13.88	9.71	5	170106	50	79574227
Fall	13.86	9.71	1214	168897	486415	79087862
Impulse-control disorder	13.86	9.71	18	170093	1756	79572521
Haemolysis	13.84	9.71	5	170106	12807	79561470
Hypoprolactinaemia	13.83	9.71	4	170107	18	79574259
Legal problem	13.78	9.71	7	170104	171	79574106
Venoocclusive liver disease	13.76	9.71	4	170107	11767	79562510
Heart disease congenital	13.75	9.71	11	170100	601	79573676
Renal disorder	13.72	9.71	45	170066	42060	79532217
Premature baby	13.69	9.71	27	170084	3753	79570524
Bradykinesia	13.67	9.71	43	170068	8000	79566277
Ventricular hypertrophy	13.59	9.71	39	170072	6899	79567378
Purple glove syndrome	13.57	9.71	8	170103	264	79574013
Alcohol withdrawal syndrome	13.57	9.71	19	170092	1992	79572285
Blood triglycerides increased	13.54	9.71	84	170027	20956	79553321
Asthenia	13.49	9.71	925	169186	510764	79063513
Hypoxic-ischaemic encephalopathy	13.47	9.71	42	170069	7778	79566499
Cardiac output increased	13.46	9.71	8	170103	268	79574009
Full blood count abnormal	13.37	9.71	43	170068	40431	79533846
Respiratory failure	13.37	9.71	289	169822	180622	79393655
Second primary malignancy	13.29	9.71	7	170104	14343	79559934
Interstitial lung disease	13.25	9.71	165	169946	112435	79461842
Stereotypy	13.25	9.71	13	170098	932	79573345
Multiple system atrophy	13.22	9.71	9	170102	383	79573894
Blood test abnormal	13.21	9.71	11	170100	17699	79556578
Renal failure	13.18	9.71	327	169784	200641	79373636
Blood creatine phosphokinase MB	13.17	9.71	4	170107	22	79574255
Heavy menstrual bleeding	13.13	9.71	62	170049	13949	79560328
Blood phosphorus increased	13.09	9.71	3	170108	10344	79563933
Dissociative identity disorder	13.07	9.71	5	170106	60	79574217
Intrusive thoughts	13.03	9.71	10	170101	514	79573763
Maternal drugs affecting foetus	13.03	9.71	17	170094	1666	79572611
Jaw clicking	13.02	9.71	4	170107	23	79574254
Umbilical cord around neck	13.02	9.71	4	170107	23	79574254
Hyperdynamic left ventricle	13.00	9.71	9	170102	394	79573883
Productive cough	12.98	9.71	123	169988	88208	79486069
Body temperature decreased	12.97	9.71	31	170080	32114	79542163
Plasma cell myeloma	12.89	9.71	64	170047	53195	79521082
Dissociative disorder	12.85	9.71	12	170099	809	79573468
Status migrainosus	12.85	9.71	5	170106	63	79574214
End stage renal disease	12.81	9.71	5	170106	12215	79562062
Antidepressant drug level above therapeutic	12.79	9.71	11	170100	665	79573612
Tongue biting	12.79	9.71	19	170092	2102	79572175
Drug withdrawal syndrome neonatal	12.77	9.71	8	170103	295	79573982
Rash maculo-papular	12.67	9.71	69	170042	56009	79518268
Personality change	12.62	9.71	49	170062	10121	79564156
Enterococcal infection	12.60	9.71	9	170102	15651	79558626
Premature labour	12.59	9.71	43	170068	8347	79565930
Mutism	12.55	9.71	20	170091	2352	79571925
Electrolyte depletion	12.55	9.71	9	170102	417	79573860
Compulsive hoarding	12.50	9.71	5	170106	68	79574209
Blood potassium decreased	12.49	9.71	153	169958	46359	79527918
Haemorrhage intracranial	12.46	9.71	23	170088	26170	79548107
Antisocial personality disorder	12.44	9.71	5	170106	69	79574208
Ventricular fibrillation	12.33	9.71	113	169998	31813	79542464
Disability	12.32	9.71	11	170100	17109	79557168
Psychiatric symptom	12.31	9.71	38	170073	6997	79567280
Injury	12.29	9.71	233	169878	77263	79497014
Abortion spontaneous	12.20	9.71	106	170005	29401	79544876
Lumbar radiculopathy	12.19	9.71	18	170093	1981	79572296
Cholangitis	12.18	9.71	6	170105	12770	79561507
Tremor neonatal	12.17	9.71	3	170108	6	79574271
Right aortic arch	12.17	9.71	3	170108	6	79574271
Acquired cardiac septal defect	12.17	9.71	3	170108	6	79574271
Apgar score low	12.17	9.71	3	170108	6	79574271
Intervertebral disc displacement	12.12	9.71	9	170102	440	79573837
Procedural hypertension	12.08	9.71	8	170103	325	79573952
Food allergy	12.08	9.71	4	170107	10820	79563457
Duodenal ulcer repair	12.06	9.71	5	170106	75	79574202
Developmental delay	12.06	9.71	14	170097	1217	79573060
Coagulation factor VII level decreased	12.04	9.71	7	170104	225	79574052
Nodule	12.03	9.71	19	170092	22975	79551302
Grandiosity	12.03	9.71	10	170101	577	79573700
Metastases to bone	12.03	9.71	21	170090	24406	79549871
Spontaneous haematoma	12.01	9.71	15	170096	1407	79572870
Brugada syndrome	11.99	9.71	14	170097	1224	79573053
Chemical burn	11.94	9.71	10	170101	583	79573694
Acute psychosis	11.83	9.71	27	170084	4153	79570124
Plasma cell mastitis	11.78	9.71	4	170107	33	79574244
Agonal rhythm	11.77	9.71	5	170106	80	79574197
Enthesopathy	11.76	9.71	5	170106	11603	79562674
Vascular stenosis	11.75	9.71	10	170101	596	79573681
Hypothermia	11.75	9.71	86	170025	22660	79551617
Placenta praevia	11.75	9.71	11	170100	744	79573533
Asthma	11.74	9.71	210	169901	134885	79439392
Toxic epidermal necrolysis	11.71	9.71	52	170059	44529	79529748
Muscle necrosis	11.71	9.71	15	170096	1443	79572834
Long QT syndrome congenital	11.65	9.71	6	170105	151	79574126
Gastrointestinal hypermotility	11.64	9.71	8	170103	346	79573931
Cushingoid	11.63	9.71	3	170108	9549	79564728
Blood parathyroid hormone decreased	11.57	9.71	4	170107	10532	79563745
Gout	11.54	9.71	22	170089	24727	79549550
Gastric disorder	11.53	9.71	41	170070	37392	79536885
Low birth weight baby	11.51	9.71	10	170101	613	79573664
Appendicitis perforated	11.50	9.71	23	170088	3230	79571047
Lung disorder	11.49	9.71	113	169998	80444	79493833
Theft	11.48	9.71	7	170104	246	79574031
Rabbit syndrome	11.46	9.71	8	170103	355	79573922
Skin necrosis	11.44	9.71	13	170098	18074	79556203
Affect lability	11.43	9.71	51	170060	11208	79563069
Cerebrovascular stenosis	11.40	9.71	6	170105	158	79574119
Bladder dilatation	11.39	9.71	18	170093	2101	79572176
Squamous cell carcinoma of skin	11.38	9.71	8	170103	14025	79560252
Pre-eclampsia	11.38	9.71	37	170074	7004	79567273
Neonatal respiratory distress syndrome	11.38	9.71	7	170104	250	79574027
Food interaction	11.36	9.71	16	170095	1686	79572591
Joint effusion	11.34	9.71	13	170098	18001	79556276
Psychotic behaviour	11.33	9.71	13	170098	1116	79573161
Medical diet	11.32	9.71	3	170108	9	79574268
Prostatic specific antigen increased	11.31	9.71	4	170107	10382	79563895
Haemorrhage	11.30	9.71	132	169979	90986	79483291
Red blood cell count decreased	11.28	9.71	74	170037	57439	79516838
Renal artery thrombosis	11.28	9.71	9	170102	490	79573787
Oesophageal achalasia	11.27	9.71	11	170100	783	79573494
Platelet count increased	11.27	9.71	19	170092	22387	79551890
Pulmonary fibrosis	11.26	9.71	52	170059	44060	79530217
Skin disorder	11.26	9.71	36	170075	33907	79540370
Alpha 1 globulin increased	11.23	9.71	5	170106	90	79574187
Schizoaffective disorder	11.19	9.71	18	170093	2134	79572143
Cataract	11.16	9.71	82	170029	62038	79512239
Peripheral sensory neuropathy	11.15	9.71	7	170104	13026	79561251
Pulmonary valve stenosis	11.10	9.71	4	170107	40	79574237
Hyperinsulinism	11.08	9.71	3	170108	10	79574267
Cardiomegaly	11.07	9.71	95	170016	26257	79548020
Back pain	11.06	9.71	533	169578	303647	79270630
Chronic fatigue syndrome	11.04	9.71	14	170097	1333	79572944
COVID-19	11.04	9.71	254	169857	157420	79416857
Uterine hypertonus	11.04	9.71	7	170104	264	79574013
Hypogammaglobulinaemia	11.02	9.71	7	170104	12944	79561333
Persecutory delusion	11.01	9.71	29	170082	4880	79569397
Fistula	11.00	9.71	7	170104	12933	79561344
Pulmonary toxicity	10.96	9.71	7	170104	12907	79561370
Loss of bladder sensation	10.94	9.71	5	170106	96	79574181
Blood pressure diastolic abnormal	10.90	9.71	15	170096	19187	79555090
Heart rate abnormal	10.87	9.71	33	170078	6024	79568253
Oral candidiasis	10.85	9.71	30	170081	29598	79544679
Hypertransaminasaemia	10.77	9.71	6	170105	11918	79562359
Sleep attacks	10.72	9.71	6	170105	179	79574098
Full blood count decreased	10.71	9.71	26	170085	26793	79547484
Hypertriglyceridaemia	10.68	9.71	7	170104	12733	79561544
Melanocytic hyperplasia	10.65	9.71	3	170108	12	79574265
Jaw disorder	10.65	9.71	29	170082	4977	79569300
Chronic kidney disease	10.65	9.71	90	170021	66064	79508213
Compulsions	10.62	9.71	8	170103	400	79573877
Eye colour change	10.57	9.71	8	170103	403	79573874
Head deformity	10.53	9.71	4	170107	47	79574230
Gastric hypomotility	10.52	9.71	6	170105	186	79574091
Hypervolaemia	10.50	9.71	51	170060	42639	79531638
Hypnagogic hallucination	10.46	9.71	6	170105	188	79574089
Skin cancer	10.43	9.71	10	170101	15030	79559247
Delusion of grandeur	10.37	9.71	14	170097	1418	79572859
Gaze palsy	10.33	9.71	21	170090	2984	79571293
Imprisonment	10.33	9.71	9	170102	554	79573723
Device related infection	10.27	9.71	38	170073	34256	79540021
Biliary dyskinesia	10.23	9.71	19	170092	2526	79571751
Dehydration	10.22	9.71	429	169682	247758	79326519
Food craving	10.22	9.71	15	170096	1642	79572635
Regurgitation	10.21	9.71	20	170091	2767	79571510
Clostridium difficile colitis	10.18	9.71	35	170076	32248	79542029
Withdrawal catatonia	10.15	9.71	6	170105	199	79574078
Anal incontinence	10.14	9.71	70	170041	18098	79556179
Metastases to liver	10.13	9.71	29	170082	28285	79545992
Otosalpingitis	10.11	9.71	3	170108	15	79574262
Testicular microlithiasis	10.11	9.71	3	170108	15	79574262
Pregnancy with contraceptive patch	10.11	9.71	3	170108	15	79574262
Sex hormone binding globulin decreased	10.11	9.71	3	170108	15	79574262
Alpha 2 globulin decreased	10.11	9.71	3	170108	15	79574262
Adverse event	10.11	9.71	81	170030	60133	79514144
Exposure during pregnancy	10.10	9.71	285	169826	100847	79473430
Hypoglycaemia neonatal	10.10	9.71	4	170107	53	79574224
Foetal alcohol syndrome	10.10	9.71	4	170107	53	79574224
Pneumonia bacterial	10.09	9.71	16	170095	19315	79554962
Inadequate analgesia	10.03	9.71	27	170084	4602	79569675
Carcinoid syndrome	10.02	9.71	6	170105	204	79574073
Pulmonary alveolar haemorrhage	10.01	9.71	6	170105	11451	79562826
Trismus	10.01	9.71	30	170081	5437	79568840
Colorectal cancer	10.00	9.71	3	170108	8644	79565633
Muscle neoplasm	9.96	9.71	4	170107	55	79574222
Androgen insensitivity syndrome	9.95	9.71	3	170108	16	79574261
Secondary tic	9.95	9.71	3	170108	16	79574261
Free androgen index decreased	9.95	9.71	3	170108	16	79574261
Fear of crowded places	9.95	9.71	3	170108	16	79574261
Hepatic cancer	9.95	9.71	5	170106	10524	79563753
Polydipsia psychogenic	9.91	9.71	6	170105	208	79574069
Tinnitus	9.89	9.71	141	169970	44192	79530085
Ventricular extrasystoles	9.89	9.71	74	170037	19630	79554647
Respiratory tract infection	9.88	9.71	62	170049	48627	79525650
Anticholinergic syndrome	9.86	9.71	23	170088	3588	79570689
Tooth hypoplasia	9.84	9.71	6	170105	211	79574066
Alcohol problem	9.83	9.71	4	170107	57	79574220
Febrile bone marrow aplasia	9.82	9.71	8	170103	13012	79561265
Blood glucose fluctuation	9.81	9.71	34	170077	6648	79567629
Exposure via inhalation	9.81	9.71	5	170106	123	79574154
Cyclothymic disorder	9.81	9.71	6	170105	212	79574065
Wound infection	9.78	9.71	23	170088	23968	79550309
Vasoplegia syndrome	9.78	9.71	23	170088	3607	79570670
Haemodynamic instability	9.72	9.71	67	170044	17315	79556962
Hallucination, tactile	9.72	9.71	9	170102	600	79573677

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Feeling jittery	45.63	22.91	18	774	44	88956
Exposure during pregnancy	32.11	22.91	48	744	1286	87714
Hypertonia neonatal	27.90	22.91	23	769	304	88696
Tremor neonatal	22.95	22.91	13	779	87	88913

Pharmacologic Action:

Source	Code	Description
ATC	N06AB03	NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Selective serotonin reuptake inhibitors
ATC	N06CA03	NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOLEPTICS AND PSYCHOANALEPTICS IN COMBINATION Antidepressants in combination with psycholeptics
FDA MoA	N0000000109	Serotonin Uptake Inhibitors
CHEBI has role	CHEBI:35469	antidepressants
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:50949	SSRI
CHEBI has role	CHEBI:78298	environmental contaminants
CHEBI has role	CHEBI:88188	allergenic drug
MeSH PA	D000928	Antidepressive Agents
MeSH PA	D018687	Antidepressive Agents, Second-Generation
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D065690	Cytochrome P-450 CYP2D6 Inhibitors
MeSH PA	D065607	Cytochrome P-450 Enzyme Inhibitors
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D065606	Metabolic Side Effects of Drugs and Substances
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D014179	Neurotransmitter Uptake Inhibitors
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D017367	Selective Serotonin Reuptake Inhibitors
MeSH PA	D018490	Serotonin Agents
FDA EPC	N0000175696	Serotonin Reuptake Inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Premenstrual dysphoric disorder	indication	596004
Depressive disorder	indication	35489007
Bulimia nervosa	indication	78004001
Bipolar affective disorder, current episode depression	indication	191627008	DOID:3312
Obsessive-compulsive disorder	indication	191736004	DOID:10933
Major depressive disorder	indication	370143000
Panic disorder	indication	371631005	DOID:594
Posttraumatic stress disorder	off-label use	47505003	DOID:2055
Postpartum depression	off-label use	58703003	DOID:9478
Cataplexy and narcolepsy	off-label use	193042000
Menopausal flushing	off-label use	198436008
Fibromyalgia	off-label use	203082005	DOID:631
Seasonal affective disorder	off-label use	247803002
Suicidal thoughts	contraindication	6471006
Weight gain finding	contraindication	8943002
Sinus tachycardia	contraindication	11092001
Hypercholesterolemia	contraindication	13644009
Bipolar disorder	contraindication	13746004	DOID:3312
Neuroleptic malignant syndrome	contraindication	15244003	DOID:14464
Senile dementia	contraindication	15662003
Agranulocytosis	contraindication	17182001	DOID:12987
Lowered convulsive threshold	contraindication	19260006
Cirrhosis of liver	contraindication	19943007	DOID:5082
Myocardial infarction	contraindication	22298006	DOID:5844
Hypovolemia	contraindication	28560003
Orthostatic hypotension	contraindication	28651003
Dehydration	contraindication	34095006
Upper gastrointestinal hemorrhage	contraindication	37372002
Conduction disorder of the heart	contraindication	44808001
Low blood pressure	contraindication	45007003
Bradycardia	contraindication	48867003
Syndrome of inappropriate vasopressin secretion	contraindication	55004003	DOID:3401
Paralytic ileus	contraindication	55525008	DOID:8442
Hyperlipidemia	contraindication	55822004	DOID:1168
Anorexia nervosa	contraindication	56882008	DOID:8689
Abnormal sexual function	contraindication	56925008
Hepatic failure	contraindication	59927004
Cerebrovascular disease	contraindication	62914000	DOID:6713
Blood coagulation disorder	contraindication	64779008	DOID:1247
Diabetes mellitus	contraindication	73211009	DOID:9351
Hyperglycemia	contraindication	80394007	DOID:4195
Heart failure	contraindication	84114007	DOID:6000
Epilepsy	contraindication	84757009	DOID:1826
Leukopenia	contraindication	84828003	DOID:615
Hyponatremia	contraindication	89627008
Tardive dyskinesia	contraindication	102449007
Seizure disorder	contraindication	128613002
Liver function tests abnormal	contraindication	166603001
Cerebrovascular accident	contraindication	230690007
Mania	contraindication	231494001
Hypomania	contraindication	231496004
Disease of liver	contraindication	235856003	DOID:409
Metabolic syndrome X	contraindication	237602007	DOID:14221
Hyperprolactinemia	contraindication	237662005	DOID:12700
Transient ischemic attack	contraindication	266257000	DOID:224
Esophageal dysmotility	contraindication	266434009	DOID:9192
Benign prostatic hyperplasia	contraindication	266569009
Hypertriglyceridemia	contraindication	302870006
Neutropenic disorder	contraindication	303011007	DOID:1227
Serotonin syndrome	contraindication	371089000
At risk for aspiration	contraindication	371736008
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Myocardial ischemia	contraindication	414795007	DOID:3393
Obesity	contraindication	414916001	DOID:9970
Carcinoma of female breast	contraindication	447782002
Smokes tobacco daily	contraindication	449868002

🐶 Veterinary Drug Use

Species	Use	Relation
Dogs	Separation anxiety	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Reconcile	Pegasus Laboratories Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.32	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN	INHIBITOR	Kd	9.09	WOMBAT-PK	CHEMBL
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	8.20	CHEMBL
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		IC50	6.07	CHEMBL
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	6.16	WOMBAT-PK
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Kd	6.62	WOMBAT-PK
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	6.61	WOMBAT-PK
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN	ANTAGONIST	Ki	5.30	IUPHAR
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	6.40	WOMBAT-PK
5-hydroxytryptamine receptor 6	GPCR	P50406	5HT6R_HUMAN		Ki	6.11	CHEMBL
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN		Ki	5.70	PDSP
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	6.16	DRUG MATRIX
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	5.70	WOMBAT-PK
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN		Ki	5.96	WOMBAT-PK
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN		Ki	6.05	WOMBAT-PK
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN		Ki	5.57	PDSP
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN		Ki	6	WOMBAT-PK
Muscarinic acetylcholine receptor M4	GPCR	P08173	ACM4_HUMAN		Ki	5.54	PDSP
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN		Ki	5.57	PDSP
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Kd	5.44	WOMBAT-PK
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		IC50	6.16	DRUG MATRIX
Acetylcholinesterase	Enzyme	P22303	ACES_HUMAN		IC50	6.89	CHEMBL
Potassium channel subfamily K member 2	Ion channel	O95069	KCNK2_HUMAN		IC50	4.85	CHEMBL
Histamine H3 receptor	GPCR	Q9Y5N1	HRH3_HUMAN		Ki	5.14	CHEMBL
Equilibrative nucleoside transporter 4	Transporter	Q7RTT9	S29A4_HUMAN	INHIBITOR	Ki	4.64	IUPHAR
Beta-1 adrenergic receptor	GPCR	P08588	ADRB1_HUMAN		Ki	5.36	WOMBAT-PK
Sodium-dependent serotonin transporter	Transporter		SC6A4_RAT		Ki	8.70	CHEMBL
Sodium-dependent dopamine transporter	Transporter		SC6A3_RAT		Ki	6.11	CHEMBL
5-hydroxytryptamine receptor 2A	GPCR		5HT2A_RAT	ANTAGONIST	Ki	6.50	IUPHAR
Sigma non-opioid intracellular receptor 1	Membrane receptor		SGMR1_RAT		Ki	6.62	CHEMBL
Transporter	Transporter		Q9WTR4_RAT		Ki	6.84	CHEMBL
Sodium-dependent dopamine transporter	Transporter		SC6A3_MOUSE		Ki	7.97	CHEMBL
Sodium-dependent noradrenaline transporter	Transporter		SC6A2_MOUSE		Ki	7.07	CHEMBL
5-hydroxytryptamine receptor 2C	GPCR		5HT2C_RAT		Ki	6.96	CHEMBL
5-hydroxytryptamine receptor 6	GPCR		5HT6R_RAT	ANTAGONIST	Ki	5.80	IUPHAR
Transporter	Transporter		Q63380_RAT		Ki	6.80	CHEMBL
Serotonin 1 (5-HT1) receptor	GPCR		5HT1A_RAT 5HT1B_RAT 5HT1D_RAT 5HT1F_RAT		IC50	7.82	CHEMBL
Adrenergic receptor alpha-2	GPCR		ADA2B_RAT ADA2C_RAT ADA2A_RAT		Ki	5.72	CHEMBL
Adrenergic receptor alpha-1	GPCR		ADA1B_RAT ADA1D_RAT ADA1A_RAT		Ki	6.22	CHEMBL
Potassium voltage-gated channel subfamily C member 1	Ion channel		KCNC1_RAT		IC50	4.88	CHEMBL
G protein-activated inward rectifier potassium channel 2	Ion channel		KCNJ6_MOUSE	GATING INHIBITOR	IC50	4.80	IUPHAR
Sigma intracellular receptor 2	Unclassified		SGMR2_RAT		Ki	4.79	CHEMBL

External reference:

ID	Source
D00326	KEGG_DRUG
56296-78-7	SECONDARY_CAS_RN
4019389	VANDF
4019761	VANDF
C0016365	UMLSCUI
CHEBI:5118	CHEBI
RFX	PDB_CHEM_ID
CHEMBL1201082	ChEMBL_ID
CHEMBL153036	ChEMBL_ID
CHEMBL41	ChEMBL_ID
DB00472	DRUGBANK_ID
D005473	MESH_DESCRIPTOR_UI
3386	PUBCHEM_CID
203	IUPHAR_LIGAND_ID
3883	INN_ID
01K63SUP8D	UNII
227224	RXNORM
17711	MMSL
28237	MMSL
37675	MMSL
4091	MMSL
41730	MMSL
4746	MMSL
d00236	MMSL
001514	NDDF
004613	NDDF
372767007	SNOMEDCT_US
53640004	SNOMEDCT_US
75115009	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Symbyax	HUMAN PRESCRIPTION DRUG LABEL	2	0002-3230	CAPSULE	25 mg	ORAL	NDA	34 sections
Symbyax	HUMAN PRESCRIPTION DRUG LABEL	2	0002-3230	CAPSULE	25 mg	ORAL	NDA	34 sections
Symbyax	HUMAN PRESCRIPTION DRUG LABEL	2	0002-3231	CAPSULE	25 mg	ORAL	NDA	34 sections
Symbyax	HUMAN PRESCRIPTION DRUG LABEL	2	0002-3231	CAPSULE	25 mg	ORAL	NDA	34 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0807	TABLET, FILM COATED	20 mg	ORAL	ANDA	32 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0807	TABLET, FILM COATED	20 mg	ORAL	ANDA	32 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0807	TABLET, FILM COATED	20 mg	ORAL	ANDA	32 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0093-5262	TABLET, FILM COATED	60 mg	ORAL	ANDA	32 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0093-5262	TABLET, FILM COATED	60 mg	ORAL	ANDA	32 sections
Olanzapine and Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	2	0093-5503	CAPSULE	25 mg	ORAL	ANDA	32 sections
Olanzapine and Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	2	0093-5504	CAPSULE	25 mg	ORAL	ANDA	32 sections
Olanzapine and Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	2	0093-5505	CAPSULE	50 mg	ORAL	ANDA	32 sections
Olanzapine and Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	2	0093-5506	CAPSULE	25 mg	ORAL	ANDA	32 sections
Olanzapine and Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	2	0093-5507	CAPSULE	50 mg	ORAL	ANDA	32 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7188	TABLET, FILM COATED	10 mg	ORAL	ANDA	32 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7188	TABLET, FILM COATED	10 mg	ORAL	ANDA	32 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7188	TABLET, FILM COATED	10 mg	ORAL	ANDA	32 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7198	CAPSULE	40 mg	ORAL	ANDA	31 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7198	CAPSULE	40 mg	ORAL	ANDA	31 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7198	CAPSULE	40 mg	ORAL	ANDA	31 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0121-0721	SOLUTION	20 mg	ORAL	ANDA	33 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0121-0721	SOLUTION	20 mg	ORAL	ANDA	33 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0121-4721	SOLUTION	20 mg	ORAL	ANDA	33 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0121-4721	SOLUTION	20 mg	ORAL	ANDA	33 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0615-1384	CAPSULE	10 mg	ORAL	ANDA	33 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7625	CAPSULE	20 mg	ORAL	ANDA	32 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7625	CAPSULE	20 mg	ORAL	ANDA	32 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7638	CAPSULE	10 mg	ORAL	ANDA	32 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8093	CAPSULE	10 mg	ORAL	ANDA	32 sections
Fluoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8093	CAPSULE	10 mg	ORAL	ANDA	32 sections