fluoxetine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives 1209 54910-89-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prozac
  • fluoxetine
  • fluoxetine hydrochloride
  • fluoxetin
  • fluoxetine HCl
The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
  • Molecular weight: 309.33
  • Formula: C17H18F3NO
  • CLOGP: 4.57
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 21.26
  • ALOGS: -5.26
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 14 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 1.25 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 4.30 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
fu (Fraction unbound in plasma) 0.02 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1987 FDA ELI LILLY AND CO

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1679.45 9.67 1886 147625 143787 63195724
Intentional overdose 1039.73 9.67 1066 148445 73086 63266425
Toxicity to various agents 982.12 9.67 1939 147572 245311 63094200
Suicidal ideation 879.69 9.67 900 148611 61521 63277990
Drug abuse 610.62 9.67 802 148709 71716 63267795
Serotonin syndrome 591.26 9.67 511 149000 28171 63311340
Suicide attempt 589.33 9.67 722 148789 60196 63279315
Intentional self-injury 585.70 9.67 485 149026 25202 63314309
Drug interaction 557.91 9.67 1482 148029 227649 63111862
Electrocardiogram QT prolonged 404.55 9.67 594 148917 58936 63280575
Systemic lupus erythematosus 367.84 9.67 34 149477 208884 63130627
Synovitis 355.87 9.67 21 149490 186897 63152614
Tremor 355.02 9.67 888 148623 131351 63208160
Hand deformity 345.15 9.67 6 149505 159451 63180060
Cardio-respiratory arrest 322.07 9.67 537 148974 59422 63280089
Anxiety 318.36 9.67 1180 148331 216361 63123150
Contraindicated product administered 309.88 9.67 67 149444 217581 63121930
Agitation 294.34 9.67 515 148996 59242 63280269
Glossodynia 280.59 9.67 43 149468 178833 63160678
Joint swelling 272.82 9.67 223 149288 327443 63012068
Wound 258.93 9.67 38 149473 163225 63176286
Infusion related reaction 256.35 9.67 129 149382 245392 63094119
Drug intolerance 255.78 9.67 211 149300 308450 63031061
Overdose 255.21 9.67 720 148791 114358 63225153
Drug withdrawal syndrome 254.26 9.67 317 149194 26877 63312634
Depression 250.80 9.67 1021 148490 195471 63144040
Pericarditis 243.80 9.67 17 149494 131562 63207949
Cardiac arrest 242.52 9.67 616 148895 91929 63247582
Alopecia 241.93 9.67 263 149248 337273 63002238
Treatment failure 240.81 9.67 84 149427 198959 63140552
Arthropathy 231 9.67 133 149378 234659 63104852
Respiratory arrest 229.33 9.67 331 149180 32314 63307197
Swelling 219.86 9.67 195 149316 275183 63064328
Withdrawal syndrome 219.60 9.67 253 149258 19744 63319767
Abdominal discomfort 219.09 9.67 260 149251 320625 63018886
Somnolence 208.09 9.67 903 148608 177782 63161729
Poisoning 200.90 9.67 202 149309 13498 63326013
Rash 192.74 9.67 677 148834 560194 62779317
Irritability 190.76 9.67 299 149212 31395 63308116
Reversible cerebral vasoconstriction syndrome 188.96 9.67 102 149409 2556 63336955
Torsade de pointes 179.73 9.67 188 149323 13163 63326348
Rheumatoid factor positive 179.27 9.67 4 149507 84402 63255109
Helicobacter infection 174.77 9.67 11 149500 92774 63246737
Duodenal ulcer perforation 171.54 9.67 8 149503 87201 63252310
Peripheral swelling 170.46 9.67 226 149285 265716 63073795
Hepatic enzyme increased 167.85 9.67 138 149373 202190 63137321
Sopor 163.42 9.67 230 149281 21934 63317577
Akathisia 158.85 9.67 148 149363 8998 63330513
Poisoning deliberate 158.28 9.67 162 149349 11056 63328455
Therapeutic product effect decreased 157.49 9.67 134 149377 193053 63146458
Disturbance in attention 153.92 9.67 302 149209 37887 63301624
Aggression 144.63 9.67 224 149287 23274 63316237
Depressed mood 144.36 9.67 303 149208 39888 63299623
Arthralgia 142.40 9.67 775 148736 568935 62770576
Infection 141.54 9.67 200 149311 228973 63110538
Coma 140.91 9.67 401 149110 63963 63275548
Drug ineffective 140.32 9.67 1683 147828 1043082 62296429
Product use issue 139.64 9.67 189 149322 220331 63119180
Nightmare 135.35 9.67 195 149316 18999 63320512
Discomfort 134.09 9.67 118 149393 167256 63172255
Folliculitis 133.43 9.67 8 149503 70309 63269202
Suicidal behaviour 130.64 9.67 80 149431 2559 63336952
Blister 124.10 9.67 76 149435 129738 63209773
Seizure 124.00 9.67 629 148882 132005 63207506
Panic attack 123.86 9.67 203 149308 22128 63317383
Febrile neutropenia 123.86 9.67 62 149449 118387 63221124
Mania 123.40 9.67 149 149362 12218 63327293
Respiratory depression 122.03 9.67 156 149355 13559 63325952
Rheumatoid arthritis 120.84 9.67 261 149250 253558 63085953
Muscle injury 119.40 9.67 9 149502 65336 63274175
Crying 117.24 9.67 203 149308 23140 63316371
Hypersensitivity 110.82 9.67 338 149173 292347 63047164
White blood cell count abnormal 110.32 9.67 102 149409 6140 63333371
Mydriasis 109.55 9.67 138 149373 11818 63327693
Product complaint 108.19 9.67 142 149369 12667 63326844
Lower respiratory tract infection 107.51 9.67 92 149419 132215 63207296
Sleep disorder due to general medical condition, insomnia type 105.31 9.67 4 149507 52213 63287298
Depressed level of consciousness 104.53 9.67 353 149158 61725 63277786
Foetal exposure during pregnancy 104.51 9.67 232 149279 31730 63307781
Suspected suicide 104.01 9.67 101 149410 6467 63333044
Impaired healing 103.75 9.67 56 149455 102486 63237025
Product substitution issue 101.98 9.67 155 149356 15841 63323670
Muscle rigidity 97.92 9.67 128 149383 11372 63328139
Galactorrhoea 97.90 9.67 80 149431 4075 63335436
Stomatitis 96.02 9.67 111 149400 138614 63200897
Nasopharyngitis 95.95 9.67 294 149217 253963 63085548
Electrocardiogram QRS complex prolonged 93.45 9.67 91 149420 5847 63333664
General physical health deterioration 91.00 9.67 213 149298 201189 63138322
Bezoar 90.55 9.67 52 149459 1474 63338037
Tardive dyskinesia 89.05 9.67 105 149406 8397 63331114
Rheumatic fever 87.99 9.67 3 149508 43108 63296403
Coma scale abnormal 86.82 9.67 82 149429 5071 63334440
Dystonia 85.41 9.67 132 149379 13687 63325824
Pneumonia 84.80 9.67 679 148832 456088 62883423
Self-injurious ideation 84.13 9.67 61 149450 2598 63336913
Generalised tonic-clonic seizure 83.18 9.67 200 149311 28816 63310695
Anger 79.83 9.67 121 149390 12335 63327176
Muscle twitching 78.59 9.67 155 149356 19513 63319998
Insomnia 78.29 9.67 813 148698 214439 63125072
Mobility decreased 77.49 9.67 103 149408 121056 63218455
Extrapyramidal disorder 76.71 9.67 123 149388 13161 63326350
Abnormal behaviour 76.31 9.67 161 149350 21265 63318246
Neutropenia 75.95 9.67 189 149322 174816 63164695
Drug dependence 75.90 9.67 174 149337 24309 63315202
Tearfulness 75.80 9.67 69 149442 4070 63335441
Off label use 73.62 9.67 1132 148379 673330 62666181
Obsessive-compulsive disorder 73.02 9.67 67 149444 3993 63335518
Restlessness 72.90 9.67 192 149319 29261 63310250
Gastrointestinal disorder 72.85 9.67 123 149388 131116 63208395
Mood swings 71.93 9.67 143 149368 18105 63321406
Pyrexia 70.95 9.67 737 148774 469741 62869770
Miosis 70.78 9.67 87 149424 7266 63332245
Intentional product use issue 69.94 9.67 121 149390 127771 63211740
Hypertonia neonatal 69.90 9.67 25 149486 219 63339292
Myoclonus 69.47 9.67 130 149381 15738 63323773
Hyperhidrosis 69.17 9.67 463 149048 107373 63232138
Dyskinesia 68.67 9.67 198 149313 31804 63307707
C-reactive protein increased 68.57 9.67 73 149438 94634 63244877
Therapeutic product effect incomplete 67.77 9.67 119 149392 124937 63214574
Parkinsonism 67.74 9.67 102 149409 10337 63329174
Hyperprolactinaemia 67.51 9.67 63 149448 3837 63335674
Ill-defined disorder 67.44 9.67 56 149455 81699 63257812
Restless legs syndrome 66.87 9.67 140 149371 18391 63321120
Hip arthroplasty 65.07 9.67 16 149495 47630 63291881
Pain 63.93 9.67 1296 148215 739332 62600179
Disease progression 62.80 9.67 121 149390 122637 63216874
Hallucination, auditory 62.41 9.67 110 149401 12714 63326797
Intentional product misuse 61.94 9.67 296 149215 60621 63278890
Emotional distress 61.92 9.67 193 149318 32356 63307155
Paranoia 61.85 9.67 104 149407 11575 63327936
Drug withdrawal syndrome neonatal 59.69 9.67 45 149466 2036 63337475
Tachycardia 59.57 9.67 479 149032 117677 63221834
Sedation 58.67 9.67 213 149298 38596 63300915
Malignant neoplasm progression 57.57 9.67 65 149446 82056 63257455
Mood altered 57.47 9.67 115 149396 14628 63324883
Therapeutic response unexpected 56.69 9.67 132 149379 18627 63320884
Tic 55.35 9.67 38 149473 1482 63338029
Bradyphrenia 55.29 9.67 75 149436 6905 63332606
Cholecystitis chronic 54.52 9.67 92 149419 10269 63329242
Irritable bowel syndrome 52.74 9.67 70 149441 82342 63257169
Pulseless electrical activity 52.42 9.67 76 149435 7445 63332066
Myocardial depression 52.38 9.67 25 149486 479 63339032
Libido increased 52.26 9.67 35 149476 1310 63338201
Abnormal dreams 52.21 9.67 91 149420 10425 63329086
Depressive symptom 52.08 9.67 56 149455 4046 63335465
Pancytopenia 51.82 9.67 93 149418 96840 63242671
Knee arthroplasty 51.41 9.67 32 149479 54174 63285337
Cerebral vasoconstriction 50.73 9.67 33 149478 1175 63338336
Decorticate posture 50.47 9.67 21 149490 286 63339225
Hyperreflexia 50.45 9.67 66 149445 5868 63333643
Hostility 50.43 9.67 39 149472 1833 63337678
Sinus bradycardia 50.27 9.67 108 149403 14443 63325068
Sinusitis 50.19 9.67 320 149191 226333 63113178
Thrombocytopenia 49.98 9.67 185 149326 150972 63188539
Platelet count decreased 49.90 9.67 126 149385 115996 63223515
Stress cardiomyopathy 49.84 9.67 84 149427 9366 63330145
Alcohol interaction 49.77 9.67 43 149468 2366 63337145
Atrial septal defect 49.66 9.67 71 149440 6867 63332644
Impulsive behaviour 49.37 9.67 36 149475 1547 63337964
Dependence 48.95 9.67 40 149471 2037 63337474
Persistent genital arousal disorder 48.50 9.67 20 149491 266 63339245
Memory impairment 48.45 9.67 415 149096 103843 63235668
Clonus 48.13 9.67 57 149454 4579 63334932
Acute respiratory distress syndrome 47.05 9.67 142 149369 23392 63316119
Renal impairment 47.03 9.67 85 149426 88270 63251241
Eosinophilic pneumonia acute 46.94 9.67 22 149489 404 63339107
Multiple sclerosis 46.81 9.67 145 149366 24227 63315284
Dyspnoea 46.31 9.67 1195 148316 660118 62679393
Anaemia 46.07 9.67 455 149056 292975 63046536
Feeling abnormal 45.90 9.67 543 148968 147849 63191662
Long QT syndrome 45.61 9.67 47 149464 3232 63336279
Mucosal inflammation 45.48 9.67 27 149484 46901 63292610
Exposure during pregnancy 45.42 9.67 563 148948 154984 63184527
Catatonia 44.76 9.67 54 149457 4423 63335088
Speech disorder 44.67 9.67 202 149309 40427 63299084
Accidental death 44.37 9.67 37 149474 1939 63337572
Maternal exposure during breast feeding 43.79 9.67 52 149459 4189 63335322
Red blood cell sedimentation rate increased 43.06 9.67 25 149486 43957 63295554
Blood pressure fluctuation 43.02 9.67 28 149483 46289 63293222
Inappropriate antidiuretic hormone secretion 42.63 9.67 105 149406 15357 63324154
Abortion missed 42.41 9.67 34 149477 1685 63337826
Confusional state 42.36 9.67 787 148724 235593 63103918
Apathy 42.24 9.67 75 149436 8719 63330792
Cerebral microhaemorrhage 42.18 9.67 15 149496 129 63339382
Ventricular fibrillation 42.05 9.67 89 149422 11778 63327733
Morbid thoughts 41.77 9.67 23 149488 600 63338911
Pre-eclampsia 41.46 9.67 76 149435 9057 63330454
Accidental overdose 41.40 9.67 135 149376 23174 63316337
Fear 41.30 9.67 105 149406 15661 63323850
Atrial fibrillation 41.06 9.67 139 149372 116497 63223014
Arthritis 40.91 9.67 138 149373 115783 63223728
Dermatitis atopic 40.51 9.67 78 149433 9646 63329865
Blood hyposmosis 39.60 9.67 10 149501 20 63339491
Maternal drugs affecting foetus 39.53 9.67 55 149456 5187 63334324
Unresponsive to stimuli 39.34 9.67 171 149340 33645 63305866
Agitation neonatal 39.27 9.67 21 149490 516 63338995
Dysarthria 38.78 9.67 201 149310 42510 63297001
Joint range of motion decreased 38.63 9.67 14 149497 32414 63307097
Antipsychotic drug level increased 38.62 9.67 44 149467 3391 63336120
Hyponatraemia 38.45 9.67 418 149093 111482 63228029
Hallucination, visual 38.16 9.67 116 149395 19182 63320329
Urinary incontinence 38.10 9.67 163 149348 31851 63307660
Hypotonia neonatal 38.10 9.67 28 149483 1218 63338293
Major depression 38.02 9.67 68 149443 7950 63331561
Euphoric mood 37.94 9.67 52 149459 4835 63334676
Respiration abnormal 37.85 9.67 60 149451 6357 63333154
Anorgasmia 36.99 9.67 21 149490 582 63338929
Sinus tachycardia 36.51 9.67 133 149378 24135 63315376
Heart sounds 36.51 9.67 25 149486 971 63338540
Stress 36.43 9.67 277 149234 66890 63272621
Inflammation 36.33 9.67 88 149423 82185 63257326
Diarrhoea 36.29 9.67 1349 148162 714017 62625494
Traumatic coma 35.07 9.67 11 149500 61 63339450
Talipes 34.92 9.67 29 149482 1511 63338000
Atrioventricular block first degree 34.90 9.67 62 149449 7211 63332300
Mental disorder 34.82 9.67 137 149374 25782 63313729
Fibromyalgia 34.74 9.67 87 149424 80333 63259178
Blood prolactin increased 34.61 9.67 42 149469 3461 63336050
Cogwheel rigidity 34.44 9.67 32 149479 1938 63337573
Prolonged expiration 34.35 9.67 25 149486 1071 63338440
Myelosuppression 34.29 9.67 7 149504 23696 63315815
Oculogyric crisis 34.11 9.67 30 149481 1691 63337820
Amnesia 34.04 9.67 236 149275 55349 63284162
Maternal exposure during pregnancy 33.78 9.67 343 149168 219719 63119792
Cough 33.62 9.67 486 149025 292257 63047254
Metabolic acidosis 33.52 9.67 201 149310 44868 63294643
Physical assault 33.44 9.67 23 149488 900 63338611
Soft tissue injury 33.15 9.67 29 149482 1623 63337888
Cystostomy 33.15 9.67 11 149500 75 63339436
Cytomegalovirus infection 32.90 9.67 5 149506 20947 63318564
Lethargy 32.66 9.67 235 149276 55772 63283739
Hypertonia 32.52 9.67 47 149464 4590 63334921
Ventricular hypokinesia 32.47 9.67 47 149464 4597 63334914
Blood creatinine increased 32.08 9.67 103 149408 87741 63251770
Bone marrow oedema syndrome 31.91 9.67 9 149502 32 63339479
Cardiac failure 31.53 9.67 106 149405 89036 63250475
Neuropathy peripheral 31.43 9.67 149 149362 113518 63225993
Multiple sclerosis relapse 30.98 9.67 208 149303 48270 63291241
Mental impairment 30.79 9.67 88 149423 14063 63325448
Heart disease congenital 30.58 9.67 25 149486 1274 63338237
Musculoskeletal pain 30.45 9.67 113 149398 92164 63247347
Panic reaction 30.29 9.67 43 149468 4131 63335380
Fatigue 30.07 9.67 1749 147762 886279 62453232
Blood lactic acid decreased 30.06 9.67 12 149499 146 63339365
Breech presentation 29.92 9.67 24 149487 1190 63338321
Psychotic disorder 29.90 9.67 130 149381 25582 63313929
Loss of libido 29.75 9.67 25 149486 1324 63338187
Psoriatic arthropathy 29.60 9.67 113 149398 91407 63248104
Breast discomfort 29.41 9.67 17 149494 488 63339023
Hallucination 29.13 9.67 225 149286 54592 63284919
Sternal fracture 29.02 9.67 31 149480 2223 63337288
Dissociation 28.84 9.67 35 149476 2884 63336627
Depression suicidal 28.80 9.67 28 149483 1795 63337716
Neoplasm progression 28.76 9.67 26 149485 36402 63303109
Herpes zoster 28.52 9.67 99 149412 82363 63257148
Loss of consciousness 28.46 9.67 413 149098 117708 63221803
Hyperthermia 28.29 9.67 65 149446 9091 63330420
Blood lactate dehydrogenase increased 27.50 9.67 10 149501 23106 63316405
Delusion of grandeur 27.38 9.67 13 149498 246 63339265
Drug level increased 27.24 9.67 116 149395 22620 63316891
Drug abuser 27.19 9.67 34 149477 2889 63336622
Alcoholism 27.01 9.67 27 149484 1791 63337720
Thinking abnormal 26.97 9.67 70 149441 10573 63328938
Burning mouth syndrome 26.60 9.67 16 149495 495 63339016
Septic shock 26.57 9.67 75 149436 66554 63272957
Flat affect 26.22 9.67 24 149487 1426 63338085
Pulmonary valve stenosis 26.18 9.67 14 149497 344 63339167
Protein C increased 26.03 9.67 10 149501 109 63339402
Dysphoria 26.00 9.67 44 149467 4922 63334589
Attention-seeking behaviour 25.99 9.67 9 149502 71 63339440
Marital problem 25.97 9.67 11 149500 157 63339354
Persistent foetal circulation 25.82 9.67 12 149499 216 63339295
Concussion 25.72 9.67 63 149448 9181 63330330
Breast enlargement 25.61 9.67 25 149486 1611 63337900
Blood pressure measurement 25.53 9.67 13 149498 288 63339223
Psychomotor retardation 25.37 9.67 38 149473 3832 63335679
Pleural effusion 25.29 9.67 123 149388 93087 63246424
Pulmonary haemosiderosis 25.27 9.67 5 149506 0 63339511
Disinhibition 25.12 9.67 19 149492 864 63338647
Bulimia nervosa 25.09 9.67 15 149496 459 63339052
Affect lability 24.90 9.67 70 149441 11081 63328430
Psychomotor hyperactivity 24.86 9.67 68 149443 10595 63328916
Agoraphobia 24.86 9.67 14 149497 382 63339129
Small for dates baby 24.83 9.67 37 149474 3714 63335797
Posture abnormal 24.75 9.67 29 149482 2303 63337208
Trichotillomania 24.59 9.67 10 149501 128 63339383
Hypomania 24.22 9.67 49 149462 6281 63333230
Poor quality sleep 24.11 9.67 102 149409 19833 63319678
Disorientation 23.85 9.67 167 149344 39285 63300226
Developmental delay 23.85 9.67 23 149488 1460 63338051
Yawning 23.79 9.67 20 149491 1060 63338451
Formication 23.78 9.67 39 149472 4252 63335259
Erythema 23.74 9.67 282 149229 175469 63164042
Prescribed underdose 23.67 9.67 21 149490 29668 63309843
Drug tolerance decreased 23.60 9.67 6 149505 17467 63322044
Hypothermia 23.53 9.67 78 149433 13503 63326008
Vitamin B1 decreased 23.52 9.67 11 149500 201 63339310
Leukocytosis 23.50 9.67 122 149389 25813 63313698
Reduced facial expression 23.50 9.67 26 149485 1940 63337571
Emotional poverty 23.37 9.67 13 149498 346 63339165
Emotional disorder 23.32 9.67 77 149434 13302 63326209
Gallbladder disorder 23.25 9.67 97 149414 18745 63320766
Type 2 diabetes mellitus 23.24 9.67 75 149436 63793 63275718
Bursitis 23.15 9.67 32 149479 37009 63302502
Grip strength decreased 22.78 9.67 12 149499 22275 63317236
Fall 22.61 9.67 1135 148376 391199 62948312
Self esteem decreased 22.58 9.67 16 149495 657 63338854
Drug hypersensitivity 22.56 9.67 558 148953 310129 63029382
White blood cell count decreased 22.51 9.67 214 149297 138890 63200621
Diet failure 22.44 9.67 7 149504 38 63339473
Heart rate 22.38 9.67 8 149503 70 63339441
Bone erosion 22.23 9.67 7 149504 17710 63321801
Gestational diabetes 22.08 9.67 56 149455 8340 63331171
Swollen tongue 22.04 9.67 149 149362 34651 63304860
Pulmonary valve stenosis congenital 21.93 9.67 10 149501 172 63339339
Bone marrow failure 21.84 9.67 22 149489 29268 63310243
Neonatal complications of substance abuse 21.81 9.67 5 149506 5 63339506
Liver disorder 21.72 9.67 60 149451 53627 63285884
Induced abortion failed 21.71 9.67 11 149500 241 63339270
Food interaction 21.58 9.67 17 149494 821 63338690
Lip dry 21.50 9.67 5 149506 15465 63324046
Ventricular arrhythmia 21.49 9.67 35 149476 3793 63335718
Narcolepsy 21.46 9.67 21 149490 1357 63338154
Pulmonary fibrosis 21.44 9.67 38 149473 39771 63299740
CYP3A4 polymorphism 21.43 9.67 8 149503 80 63339431
Haemoglobin decreased 21.39 9.67 229 149282 145256 63194255
Acute kidney injury 21.39 9.67 465 149046 262950 63076561
Sleep-related eating disorder 21.35 9.67 17 149494 834 63338677
Hypotension 21.33 9.67 814 148697 271790 63067721
Somnambulism 21.32 9.67 43 149468 5500 63334011
Dizziness 21.24 9.67 1226 148285 428699 62910812
Weight increased 21.19 9.67 782 148729 260010 63079501
Eating disorder symptom 20.97 9.67 9 149502 133 63339378
Liver function test increased 20.85 9.67 28 149483 32783 63306728
Bruxism 20.85 9.67 33 149478 3492 63336019
Aortic bruit 20.72 9.67 6 149505 24 63339487
Post-traumatic neck syndrome 20.71 9.67 25 149486 2049 63337462
Blood pressure systolic increased 20.68 9.67 51 149460 47346 63292165
Neuroleptic malignant syndrome 20.67 9.67 69 149442 11987 63327524
IIIrd nerve paresis 20.67 9.67 9 149502 138 63339373
Homicidal ideation 20.65 9.67 23 149488 1729 63337782
Eye movement disorder 20.64 9.67 41 149470 5187 63334324
Complication of device insertion 20.46 9.67 51 149460 7513 63331998
Infantile apnoea 20.46 9.67 18 149493 1015 63338496
Electrocardiogram repolarisation abnormality 20.38 9.67 20 149491 1297 63338214
Balance disorder 20.26 9.67 295 149216 84127 63255384
Maternal exposure via partner during pregnancy 20.21 9.67 4 149507 0 63339511
Posterior segment of eye anomaly congenital 20.21 9.67 4 149507 0 63339511
Foetal alcohol syndrome 20.16 9.67 6 149505 27 63339484
Patent ductus arteriosus 20.09 9.67 36 149475 4214 63335297
Device placement issue 20.09 9.67 20 149491 1320 63338191
Dysphemia 20.07 9.67 28 149483 2647 63336864
Incubator therapy 20.02 9.67 7 149504 57 63339454
Borderline personality disorder 19.92 9.67 16 149495 795 63338716
Feeling guilty 19.91 9.67 14 149497 568 63338943
Osteoarthritis 19.87 9.67 137 149374 95206 63244305
Nervousness 19.84 9.67 133 149378 30846 63308665
Brugada syndrome 19.82 9.67 12 149499 376 63339135
Intrusive thoughts 19.78 9.67 10 149501 218 63339293
Tongue biting 19.74 9.67 21 149490 1499 63338012
Ideas of reference 19.70 9.67 8 149503 102 63339409
Peripheral venous disease 19.63 9.67 6 149505 15471 63324040
Adverse event 19.60 9.67 87 149424 67472 63272039
Primitive reflex test positive 19.48 9.67 5 149506 11 63339500
Respiratory disorder neonatal 19.44 9.67 19 149492 1226 63338285
Appetite disorder 19.43 9.67 49 149462 7272 63332239
Pruritus 19.28 9.67 677 148834 360776 62978735
Serum sickness-like reaction 19.17 9.67 13 149498 497 63339014
Bipolar I disorder 19.14 9.67 23 149488 1876 63337635
Gaze palsy 19.12 9.67 20 149491 1400 63338111
Procedural hypertension 19.12 9.67 11 149500 313 63339198
Hypertonic bladder 19.06 9.67 32 149479 3556 63335955
Anhedonia 18.99 9.67 63 149448 10911 63328600
Foetal arrhythmia 18.97 9.67 9 149502 170 63339341
Musculoskeletal stiffness 18.96 9.67 313 149198 184305 63155206
Cholelithiasis 18.92 9.67 172 149339 43753 63295758
Constipation 18.86 9.67 395 149116 224548 63114963
Ventricular tachycardia 18.81 9.67 95 149416 19884 63319627
Neonatal hypoxia 18.81 9.67 14 149497 621 63338890
Drug screen positive 18.80 9.67 32 149479 3597 63335914
Libido decreased 18.62 9.67 27 149484 2645 63336866
Placenta praevia 18.61 9.67 17 149494 1007 63338504
Slow response to stimuli 18.50 9.67 17 149494 1015 63338496
Bradykinesia 18.49 9.67 39 149472 5149 63334362
Ventricular extrasystoles 18.39 9.67 65 149446 11622 63327889
Anterograde amnesia 18.34 9.67 13 149498 534 63338977
Atrioventricular block second degree 18.31 9.67 33 149478 3881 63335630
Gastric bypass 18.30 9.67 22 149489 1795 63337716
Affective disorder 18.30 9.67 43 149468 6103 63333408
Posterior reversible encephalopathy syndrome 18.24 9.67 9 149502 17336 63322175
Sudden onset of sleep 18.21 9.67 13 149498 540 63338971
Cholecystectomy 18.21 9.67 61 149450 10616 63328895
Oppositional defiant disorder 18.20 9.67 6 149505 40 63339471
Hypercalcaemia 18.17 9.67 24 149487 28298 63311213
Spinal shock 18.13 9.67 5 149506 16 63339495
Feeling jittery 18.13 9.67 71 149440 13332 63326179
pH body fluid increased 17.98 9.67 4 149507 3 63339508
Optic ischaemic neuropathy 17.88 9.67 18 149493 1204 63338307
Angle closure glaucoma 17.82 9.67 24 149487 2195 63337316
Hypersomnia 17.82 9.67 87 149424 17968 63321543
Drug eruption 17.72 9.67 25 149486 28669 63310842
Regurgitation 17.67 9.67 21 149490 1693 63337818
Prolonged labour 17.66 9.67 13 149498 567 63338944
Sepsis 17.63 9.67 254 149257 152869 63186642
Supraventricular tachyarrhythmia 17.62 9.67 7 149504 84 63339427
Psoriasis 17.50 9.67 295 149216 86662 63252849
Alcohol use 17.48 9.67 23 149488 2056 63337455
Atelectasis neonatal 17.47 9.67 5 149506 19 63339492
Influenza like illness 17.44 9.67 237 149274 66587 63272924
Binge eating 17.43 9.67 12 149499 470 63339041
Macular degeneration 17.40 9.67 19 149492 24357 63315154
Chronic fatigue syndrome 17.34 9.67 17 149494 1101 63338410
Oesophageal food impaction 17.33 9.67 9 149502 208 63339303
Neonatal respiratory distress 17.10 9.67 11 149500 384 63339127
Electrolyte depletion 17.10 9.67 9 149502 214 63339297
Migraine 17.08 9.67 340 149171 103006 63236505
Prolonged rupture of membranes 17.04 9.67 6 149505 50 63339461
Congenital brain damage 16.98 9.67 4 149507 5 63339506
Hallucinations, mixed 16.86 9.67 36 149475 4793 63334718
Therapy non-responder 16.86 9.67 107 149404 75794 63263717
Bipolar disorder 16.83 9.67 49 149462 7911 63331600
Personality change 16.79 9.67 45 149466 6928 63332583
Toxic epidermal necrolysis 16.74 9.67 21 149490 25313 63314198
Oedema 16.74 9.67 148 149363 97474 63242037
Facet joint syndrome 16.72 9.67 4 149507 12134 63327377
Pre-existing condition improved 16.72 9.67 50 149461 8194 63331317
Neonatal asphyxia 16.70 9.67 10 149501 307 63339204
Inadequate analgesia 16.65 9.67 27 149484 2916 63336595
Energy increased 16.64 9.67 26 149485 2721 63336790
Condition aggravated 16.59 9.67 776 148735 401441 62938070
Polydactyly 16.58 9.67 10 149501 311 63339200
Analgesic drug level increased 16.58 9.67 24 149487 2348 63337163
Dermatillomania 16.54 9.67 8 149503 158 63339353
Agonal rhythm 16.54 9.67 5 149506 24 63339487
Increased appetite 16.41 9.67 55 149456 9575 63329936
Heavy menstrual bleeding 16.38 9.67 84 149427 17689 63321822
Creatinine renal clearance decreased 16.35 9.67 9 149502 16299 63323212
Therapeutic response decreased 16.22 9.67 82 149429 61443 63278068
Foetal monitoring abnormal 16.17 9.67 9 149502 240 63339271
Tachyphrenia 16.13 9.67 18 149493 1356 63338155
Jaundice neonatal 16.12 9.67 15 149496 910 63338601
Acute myopia 16.10 9.67 7 149504 107 63339404
Decreased interest 15.95 9.67 28 149483 3226 63336285
Nystagmus 15.85 9.67 41 149470 6179 63333332
Single umbilical artery 15.74 9.67 9 149502 253 63339258
Dysmorphism 15.71 9.67 23 149488 2273 63337238
Blunted affect 15.71 9.67 9 149502 254 63339257
Phobia 15.68 9.67 10 149501 344 63339167
Hyporesponsive to stimuli 15.68 9.67 16 149495 1088 63338423
Menstruation irregular 15.67 9.67 44 149467 6960 63332551
Tooth hypoplasia 15.65 9.67 6 149505 65 63339446
Alcohol withdrawal syndrome 15.56 9.67 14 149497 813 63338698
Anorexia nervosa 15.49 9.67 9 149502 261 63339250
Mononucleosis syndrome 15.48 9.67 8 149503 183 63339328
Skin ulcer 15.34 9.67 51 149460 42994 63296517
Pulmonary vasculitis 15.32 9.67 7 149504 121 63339390
Anal incontinence 15.29 9.67 68 149443 13508 63326003
Obsessive thoughts 15.24 9.67 12 149499 579 63338932
Staring 15.23 9.67 19 149492 1611 63337900
Panniculitis 15.20 9.67 4 149507 11381 63328130
Osteonecrosis of jaw 15.16 9.67 38 149473 35085 63304426
Abortion spontaneous 15.15 9.67 174 149337 47021 63292490
Tension 15.15 9.67 27 149484 3148 63336363
Umbilical cord around neck 15.09 9.67 8 149503 193 63339318
Psychotic behaviour 15.08 9.67 12 149499 588 63338923
Vertigo 15.06 9.67 211 149300 59676 63279835
Disturbance in sexual arousal 15.01 9.67 7 149504 127 63339384
Cleft palate 14.98 9.67 15 149496 997 63338514
Theft 14.81 9.67 6 149505 76 63339435
Polyneuropathy 14.70 9.67 8 149503 14581 63324930
Pleurothotonus 14.69 9.67 17 149494 1332 63338179
Purple glove syndrome 14.66 9.67 8 149503 205 63339306
Spontaneous haematoma 14.64 9.67 14 149497 879 63338632
Amenorrhoea 14.63 9.67 54 149457 9860 63329651
Feeling drunk 14.60 9.67 31 149480 4111 63335400
Cold agglutinins positive 14.60 9.67 5 149506 38 63339473
Plasma cell mastitis 14.49 9.67 5 149506 39 63339472
Transient aphasia 14.49 9.67 5 149506 39 63339472
Hypoprolactinaemia 14.46 9.67 4 149507 13 63339498
Parkinsonian gait 14.39 9.67 11 149500 508 63339003
Vision blurred 14.39 9.67 300 149211 91624 63247887
Fluid retention 14.38 9.67 82 149429 59604 63279907
Withdrawal catatonia 14.27 9.67 6 149505 84 63339427
Palmar-plantar erythrodysaesthesia syndrome 14.26 9.67 20 149491 22995 63316516
Live birth 14.23 9.67 24 149487 25606 63313905
Negative thoughts 14.20 9.67 14 149497 913 63338598
Liver injury 14.12 9.67 84 149427 60436 63279075
Cardiac output increased 14.08 9.67 8 149503 222 63339289
Sleep paralysis 14.08 9.67 12 149499 648 63338863
Confabulation 14.08 9.67 9 149502 311 63339200
Biliary dyskinesia 14.05 9.67 24 149487 2705 63336806
Coordination abnormal 14.05 9.67 67 149444 13706 63325805
Hypouricaemia 14.04 9.67 7 149504 148 63339363
Microcephaly 14.04 9.67 14 149497 926 63338585
Chemical burn 14.02 9.67 10 149501 415 63339096
Sudden cardiac death 14.01 9.67 21 149490 2119 63337392
Gambling disorder 14.01 9.67 16 149495 1236 63338275
Feeling of despair 13.98 9.67 22 149489 2317 63337194
Cataplexy 13.97 9.67 16 149495 1240 63338271
Social anxiety disorder 13.89 9.67 10 149501 421 63339090
Hypoxic-ischaemic encephalopathy 13.88 9.67 31 149480 4256 63335255
Muscle enzyme increased 13.83 9.67 7 149504 153 63339358
Acute myeloid leukaemia 13.82 9.67 12 149499 17135 63322376
Blood pressure diastolic decreased 13.81 9.67 20 149491 22686 63316825
Swelling face 13.76 9.67 218 149293 63257 63276254
Economic problem 13.74 9.67 20 149491 1966 63337545
Sluggishness 13.71 9.67 35 149476 5234 63334277
Altered state of consciousness 13.65 9.67 104 149407 25126 63314385
Thrombotic microangiopathy 13.56 9.67 4 149507 10557 63328954
Ataxia 13.44 9.67 71 149440 15124 63324387
Pericardial effusion 13.38 9.67 32 149479 30026 63309485
Long QT syndrome congenital 13.38 9.67 6 149505 99 63339412
Basilar migraine 13.31 9.67 5 149506 51 63339460
Metastases to bone 13.29 9.67 18 149493 21001 63318510
Tenosynovitis 13.28 9.67 8 149503 13787 63325724
Neonatal disorder 13.26 9.67 11 149500 572 63338939
Blood pressure diastolic abnormal 13.22 9.67 9 149502 14533 63324978
Craniosynostosis 13.16 9.67 7 149504 170 63339341
Gait disturbance 13.15 9.67 542 148969 182636 63156875
Menopausal symptoms 13.14 9.67 22 149489 2439 63337072
Haematotoxicity 13.09 9.67 3 149508 9373 63330138
Oesophageal adenocarcinoma 13.09 9.67 7 149504 172 63339339
Pregnancy with advanced maternal age 13.09 9.67 3 149508 3 63339508
Floppy infant 13.06 9.67 6 149505 105 63339406
Loss of bladder sensation 13.06 9.67 5 149506 54 63339457
Platelet dysfunction 12.96 9.67 6 149505 107 63339404
Joint hyperextension 12.95 9.67 9 149502 358 63339153
Fear of weight gain 12.93 9.67 4 149507 21 63339490
Duodenal ulcer repair 12.89 9.67 5 149506 56 63339455
Premature labour 12.88 9.67 61 149450 12443 63327068
Amaurosis 12.85 9.67 11 149500 598 63338913
General physical condition abnormal 12.83 9.67 30 149481 4244 63335267
Depersonalisation/derealisation disorder 12.83 9.67 16 149495 1356 63338155
Cytokine release syndrome 12.83 9.67 9 149502 14305 63325206
Oesophageal achalasia 12.82 9.67 10 149501 476 63339035
Post-traumatic stress disorder 12.76 9.67 34 149477 5217 63334294
Blood pressure systolic abnormal 12.56 9.67 8 149503 13378 63326133
Joint effusion 12.51 9.67 13 149498 17047 63322464
Social avoidant behaviour 12.48 9.67 24 149487 2964 63336547
Leukopenia 12.46 9.67 119 149392 77171 63262340
Potentiating drug interaction 12.45 9.67 30 149481 4326 63335185
Brucellosis 12.37 9.67 5 149506 63 63339448
Ventricular septal defect 12.35 9.67 30 149481 4348 63335163
Jaw clicking 12.35 9.67 4 149507 25 63339486
Rhabdomyolysis 12.35 9.67 158 149353 43793 63295718
Hypnopompic hallucination 12.30 9.67 5 149506 64 63339447
Transplant rejection 12.26 9.67 5 149506 10775 63328736
Infantile vomiting 12.20 9.67 6 149505 123 63339388
Respiratory disorder 12.15 9.67 49 149462 39033 63300478
Bradycardia neonatal 12.09 9.67 13 149498 939 63338572
Body height increased 12.09 9.67 5 149506 67 63339444
Medical diet 12.09 9.67 4 149507 27 63339484
Hospitalisation 12.07 9.67 135 149376 84946 63254565
Panic disorder 12.06 9.67 22 149489 2611 63336900
Blood parathyroid hormone decreased 12.05 9.67 4 149507 9787 63329724
Multiple allergies 11.95 9.67 9 149502 13793 63325718
Blood bilirubin increased 11.91 9.67 46 149465 37094 63302417
Adverse drug reaction 11.90 9.67 125 149386 79589 63259922
Blood magnesium decreased 11.90 9.67 62 149449 13136 63326375
Carotid arterial embolus 11.88 9.67 3 149508 6 63339505
Renal adenoma 11.88 9.67 3 149508 6 63339505
Hyperinsulinism 11.88 9.67 3 149508 6 63339505
Bacteraemia 11.86 9.67 14 149497 17334 63322177
Drug use disorder 11.83 9.67 32 149479 4952 63334559
Unmasking of previously unidentified disease 11.82 9.67 13 149498 963 63338548
Extensor plantar response 11.80 9.67 15 149496 1296 63338215
Areflexia 11.77 9.67 24 149487 3094 63336417
Spina bifida occulta 11.57 9.67 3 149508 7 63339504
Peritonitis 11.56 9.67 14 149497 17140 63322371
Personality disorder 11.55 9.67 35 149476 5776 63333735
Substance abuse 11.55 9.67 31 149480 4776 63334735
Antidepressant drug level above therapeutic 11.55 9.67 9 149502 428 63339083
Basal cell carcinoma 11.53 9.67 31 149480 27960 63311551
Coeliac disease 11.53 9.67 8 149503 12789 63326722
Salivary hypersecretion 11.52 9.67 42 149469 7624 63331887
Proteinuria 11.51 9.67 17 149494 19128 63320383
Hypometabolism 11.50 9.67 4 149507 32 63339479
Status migrainosus 11.50 9.67 6 149505 140 63339371
Blood triglycerides increased 11.49 9.67 59 149452 12429 63327082
Pain in extremity 11.47 9.67 651 148860 330835 63008676
Diverticulitis 11.44 9.67 51 149460 39506 63300005
Pulmonary toxicity 11.40 9.67 4 149507 9451 63330060
Acute stress disorder 11.40 9.67 7 149504 225 63339286
Alcohol poisoning 11.40 9.67 18 149493 1901 63337610
Spasmodic dysphonia 11.35 9.67 5 149506 79 63339432
Congenital multiplex arthrogryposis 11.29 9.67 4 149507 34 63339477
Lymphocytic hypophysitis 11.29 9.67 7 149504 229 63339282
Hepatic function abnormal 11.28 9.67 47 149464 37095 63302416
Toxicologic test abnormal 11.25 9.67 11 149500 710 63338801
Urinary retention 11.25 9.67 115 149396 30186 63309325
Hyperkalaemia 11.23 9.67 78 149433 54125 63285386
Hypokalaemia 11.20 9.67 322 149189 103482 63236029
Skin disorder 11.19 9.67 34 149477 29473 63310038
Pregnancy on oral contraceptive 11.18 9.67 13 149498 1024 63338487
Dissociative identity disorder 11.18 9.67 5 149506 82 63339429
Pulmonary valve incompetence 11.17 9.67 15 149496 1368 63338143
Pelvic pain 11.16 9.67 62 149449 13457 63326054
Irregular breathing 11.05 9.67 8 149503 340 63339171
Anticholinergic syndrome 11.04 9.67 20 149491 2362 63337149
Thought insertion 11.02 9.67 3 149508 9 63339502
Tooth demineralisation 11.02 9.67 3 149508 9 63339502
Oedema peripheral 11.01 9.67 351 149160 189160 63150351
Autonomic nervous system imbalance 11.00 9.67 22 149489 2796 63336715
Muscle neoplasm 10.99 9.67 4 149507 37 63339474
Sleep attacks 10.96 9.67 5 149506 86 63339425
Skin necrosis 10.96 9.67 10 149501 13940 63325571
Factitious disorder 10.91 9.67 5 149506 87 63339424
Product deposit 10.87 9.67 7 149504 245 63339266
Gingival discomfort 10.87 9.67 8 149503 349 63339162
Food craving 10.86 9.67 16 149495 1590 63337921
Pulmonary artery stenosis congenital 10.84 9.67 7 149504 246 63339265
Periodic limb movement disorder 10.82 9.67 7 149504 247 63339264
Premature rupture of membranes 10.81 9.67 31 149480 4962 63334549
Gallbladder neoplasm 10.81 9.67 4 149507 39 63339472
Cytopenia 10.79 9.67 7 149504 11594 63327917
Antisocial personality disorder 10.79 9.67 3 149508 10 63339501
Micturition urgency 10.72 9.67 48 149463 9563 63329948
Sensation of blood flow 10.71 9.67 5 149506 91 63339420
Facial paralysis 10.68 9.67 63 149448 13978 63325533
Myasthenic syndrome 10.67 9.67 7 149504 253 63339258
Electrocardiogram QT interval 10.61 9.67 6 149505 165 63339346
Superior mesenteric artery syndrome 10.56 9.67 5 149506 94 63339417
Conduction disorder 10.48 9.67 15 149496 1452 63338059
Apgar score low 10.48 9.67 11 149500 773 63338738
Neutropenic sepsis 10.47 9.67 14 149497 16424 63323087
Lymphatic system neoplasm 10.46 9.67 4 149507 43 63339468
Pyloric stenosis 10.46 9.67 8 149503 370 63339141
Lung disorder 10.40 9.67 95 149416 62166 63277345
Verbal abuse 10.37 9.67 5 149506 98 63339413
Pleural disorder 10.34 9.67 10 149501 637 63338874
Product use in unapproved indication 10.33 9.67 332 149179 178748 63160763
Trismus 10.31 9.67 26 149485 3859 63335652
Ketonuria 10.26 9.67 10 149501 643 63338868
Lactation disorder 10.24 9.67 8 149503 382 63339129
Agranulocytosis 10.23 9.67 28 149483 25106 63314405
Drug ineffective for unapproved indication 10.23 9.67 124 149387 33939 63305572
Hyporeflexia 10.20 9.67 17 149494 1878 63337633
Cardiac output decreased 10.17 9.67 12 149499 960 63338551
Hypersexuality 10.15 9.67 9 149502 513 63338998
Embolism 10.14 9.67 3 149508 7903 63331608
Vaginal haemorrhage 10.05 9.67 104 149407 27383 63312128
Enterocolitis 10.05 9.67 3 149508 7855 63331656
Premature delivery 10.04 9.67 37 149474 30244 63309267
Road traffic accident 10 9.67 131 149380 36501 63303010
Electrocardiogram T wave inversion 9.98 9.67 24 149487 3457 63336054
Pulmonary embolism 9.98 9.67 352 149159 116332 63223179
Psychiatric symptom 9.96 9.67 31 149480 5192 63334319
Death of relative 9.95 9.67 7 149504 284 63339227
Enuresis 9.94 9.67 20 149491 2553 63336958
Bradycardia 9.89 9.67 234 149277 72993 63266518
Alpha 1 globulin increased 9.85 9.67 5 149506 110 63339401
Carbon monoxide poisoning 9.82 9.67 6 149505 191 63339320
Hypertrophic scar 9.82 9.67 3 149508 15 63339496
Spinal fusion acquired 9.82 9.67 3 149508 15 63339496
Enthesopathy 9.79 9.67 4 149507 8610 63330901
Job dissatisfaction 9.78 9.67 4 149507 52 63339459
Hypnagogic hallucination 9.77 9.67 6 149505 193 63339318
Grandiosity 9.76 9.67 7 149504 293 63339218
Uterine hypertonus 9.76 9.67 7 149504 293 63339218
Blood potassium decreased 9.74 9.67 146 149365 41880 63297631
Menstruation normal 9.74 9.67 6 149505 194 63339317
Head deformity 9.73 9.67 5 149506 113 63339398
Heart rate decreased 9.72 9.67 65 149446 45495 63294016
Antidepressant discontinuation syndrome 9.71 9.67 4 149507 53 63339458
Breath sounds abnormal 9.70 9.67 7 149504 10966 63328545
Labour induction 9.69 9.67 5 149506 114 63339397

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 998.34 11.13 554 62608 19379 34874390
Suicidal ideation 461.07 11.13 460 62702 39928 34853841
Completed suicide 428.15 11.13 691 62471 97477 34796292
Toxicity to various agents 421.04 11.13 1038 62124 199324 34694445
Suicide attempt 414.52 11.13 428 62734 38688 34855081
Intentional overdose 350.36 11.13 413 62749 43261 34850508
Drug interaction 325.23 11.13 1020 62142 224926 34668843
Obsessive-compulsive disorder 321.00 11.13 170 62992 5394 34888375
Akathisia 286.38 11.13 180 62982 7929 34885840
Euphoric mood 218.95 11.13 133 63029 5508 34888261
Antipsychotic drug level below therapeutic 203.35 11.13 97 63065 2450 34891319
Aggression 187.08 11.13 287 62875 38677 34855092
Therapeutic product effect variable 185.37 11.13 90 63072 2366 34891403
Disinhibition 184.47 11.13 98 63064 3128 34890641
Anxiety 178.06 11.13 486 62676 98942 34794827
Agitation 172.64 11.13 344 62818 57055 34836714
Drug abuse 161.37 11.13 468 62694 98628 34795141
Overdose 155.00 11.13 437 62725 90622 34803147
Increased appetite 154.19 11.13 119 63043 7310 34886459
Drug withdrawal syndrome 136.92 11.13 174 62988 19660 34874109
Depression 132.34 11.13 431 62731 96667 34797102
Homicide 127.16 11.13 52 63110 897 34892872
Irritability 121.48 11.13 184 62978 24506 34869263
Febrile neutropenia 120.90 11.13 48 63114 136801 34756968
Obesity 117.02 11.13 130 63032 12748 34881021
Drug dependence 105.96 11.13 171 62991 24046 34869723
Electrocardiogram QT prolonged 102.76 11.13 228 62934 40724 34853045
Tardive dyskinesia 95.29 11.13 81 63081 5709 34888060
Pneumonia 89.69 11.13 345 62817 362282 34531487
Depressed mood 89.46 11.13 140 63022 19177 34874592
Anaemia 83.84 11.13 186 62976 233149 34660620
Psychotic disorder 83.82 11.13 155 63007 24297 34869472
Sedation 83.40 11.13 142 63020 20864 34872905
Intentional self-injury 82.94 11.13 113 63049 13658 34880111
Pyrexia 81.55 11.13 318 62844 332695 34561074
Exposure during pregnancy 80.84 11.13 90 63072 8844 34884925
Mania 79.58 11.13 92 63070 9419 34884350
Malignant neoplasm progression 79.17 11.13 30 63132 88016 34805753
Sepsis 76.56 11.13 114 63048 166447 34727322
Tremor 74.34 11.13 321 62841 82266 34811503
Paranoia 74.16 11.13 100 63062 11968 34881801
Disease progression 72.02 11.13 54 63108 108023 34785746
Weight increased 69.96 11.13 343 62819 92690 34801079
Choreoathetosis 68.49 11.13 35 63127 1029 34892740
Suicidal behaviour 67.79 11.13 39 63123 1458 34892311
Tic 63.55 11.13 42 63120 2016 34891753
Platelet count decreased 63.10 11.13 74 63088 119643 34774126
Poisoning 62.81 11.13 93 63069 12133 34881636
Thrombocytopenia 62.47 11.13 117 63045 156130 34737639
Hyperreflexia 61.43 11.13 49 63113 3157 34890612
Sexual dysfunction 61.38 11.13 66 63096 6237 34887532
Victim of child abuse 61.15 11.13 31 63131 896 34892873
Anger 60.48 11.13 90 63072 11794 34881975
General physical health deterioration 59.69 11.13 87 63075 128182 34765587
Abnormal behaviour 59.25 11.13 136 63026 24833 34868936
Drug withdrawal syndrome neonatal 58.27 11.13 50 63112 3569 34890200
Intentional product misuse 58.07 11.13 198 62964 45413 34848356
Extrapyramidal disorder 56.40 11.13 91 63071 12789 34880980
Homicidal ideation 55.73 11.13 43 63119 2639 34891130
Social avoidant behaviour 54.20 11.13 45 63117 3069 34890700
Hallucination, auditory 53.28 11.13 85 63077 11832 34881937
Dyskinesia 53.09 11.13 122 63040 22291 34871478
Muscle twitching 49.58 11.13 76 63086 10222 34883547
Disturbance in attention 49.53 11.13 130 63032 25815 34867954
Diarrhoea 49.33 11.13 459 62703 389453 34504316
Prescribed overdose 49.06 11.13 77 63085 10570 34883199
Synaesthesia 47.86 11.13 9 63153 0 34893769
Withdrawal syndrome 47.86 11.13 83 63079 12372 34881397
Antipsychotic drug level increased 47.71 11.13 46 63116 3819 34889950
Electrocardiogram QRS complex prolonged 47.22 11.13 51 63111 4843 34888926
Parasomnia 46.94 11.13 20 63142 384 34893385
Epidural lipomatosis 46.50 11.13 27 63135 1027 34892742
Renal impairment 46.05 11.13 62 63100 94451 34799318
Respiratory depression 45.96 11.13 95 63067 16150 34877619
Dyslipidaemia 45.93 11.13 62 63100 7426 34886343
Insomnia 45.17 11.13 332 62830 103575 34790194
Pancytopenia 44.78 11.13 64 63098 95093 34798676
Major depression 44.74 11.13 48 63114 4524 34889245
Haemoglobin decreased 44.33 11.13 95 63067 120677 34773092
Bipolar disorder 44.04 11.13 43 63119 3626 34890143
Rhabdomyolysis 43.39 11.13 240 62922 67923 34825846
Torsade de pointes 43.17 11.13 59 63103 7150 34886619
Mental disorder 43.10 11.13 89 63073 15120 34878649
Infection 41.94 11.13 62 63100 90853 34802916
Nightmare 41.71 11.13 85 63077 14306 34879463
Drug abuser 41.34 11.13 43 63119 3911 34889858
Atrial fibrillation 41.11 11.13 101 63061 122292 34771477
Asphyxia 41.02 11.13 56 63106 6779 34886990
Rash 40.72 11.13 236 62926 222516 34671253
Juvenile idiopathic arthritis 40.70 11.13 31 63131 1866 34891903
Tremor neonatal 40.51 11.13 18 63144 384 34893385
Panic attack 40.42 11.13 66 63096 9366 34884403
Myoclonus 40.36 11.13 85 63077 14640 34879129
Generalised tonic-clonic seizure 40.32 11.13 106 63056 21068 34872701
Depersonalisation/derealisation disorder 39.58 11.13 20 63142 574 34893195
Leukaemia 39.30 11.13 45 63117 4558 34889211
Acute kidney injury 38.52 11.13 359 62803 304629 34589140
Visceral congestion 38.47 11.13 20 63142 610 34893159
Hepatic function abnormal 38.41 11.13 16 63146 44347 34849422
Seizure 38.38 11.13 322 62840 104535 34789234
Hyperhidrosis 38.27 11.13 251 62911 75441 34818328
Neutropenia 38.05 11.13 150 63012 156628 34737141
Maternal drugs affecting foetus 37.70 11.13 41 63121 3924 34889845
Chorea 37.05 11.13 24 63138 1113 34892656
Psychomotor hyperactivity 36.81 11.13 64 63098 9558 34884211
Mucosal inflammation 36.69 11.13 12 63150 38610 34855159
Apathy 35.99 11.13 53 63109 6879 34886890
Neuroleptic malignant syndrome 35.40 11.13 91 63071 17843 34875926
Abnormal dreams 35.18 11.13 55 63107 7523 34886246
Thinking abnormal 34.91 11.13 49 63113 6088 34887681
Delusion 34.71 11.13 73 63089 12562 34881207
Off label use 34.58 11.13 542 62620 418982 34474787
Clonus 34.46 11.13 33 63129 2717 34891052
Abnormal sleep-related event 34.22 11.13 17 63145 470 34893299
Stomatitis 34.21 11.13 17 63145 42497 34851272
Cholinergic syndrome 34.03 11.13 18 63144 569 34893200
Blood prolactin increased 33.94 11.13 27 63135 1733 34892036
Drug level increased 33.63 11.13 102 63060 21994 34871775
Priapism 33.17 11.13 43 63119 4951 34888818
Restless legs syndrome 32.53 11.13 56 63106 8298 34885471
Somnolence 32.43 11.13 325 62837 110791 34782978
Mood swings 32.13 11.13 54 63108 7847 34885922
Product complaint 31.99 11.13 46 63116 5844 34887925
Serum ferritin abnormal 31.54 11.13 13 63149 229 34893540
Schizoaffective disorder 31.40 11.13 23 63139 1304 34892465
Nervousness 31.39 11.13 70 63092 12536 34881233
Septic shock 31.20 11.13 51 63111 71783 34821986
Self-medication 31.18 11.13 31 63131 2672 34891097
Mast cell activation syndrome 31.13 11.13 13 63149 237 34893532
Cytomegalovirus infection 31.01 11.13 5 63157 26130 34867639
Obsessive-compulsive symptom 30.91 11.13 11 63151 127 34893642
Oral discharge 30.75 11.13 11 63151 129 34893640
Child abuse 30.29 11.13 15 63147 412 34893357
Rheumatoid arthritis 29.71 11.13 16 63146 38222 34855547
Persistent foetal circulation 29.44 11.13 14 63148 351 34893418
Hallucination 29.28 11.13 176 62986 51322 34842447
Derealisation 28.23 11.13 16 63146 581 34893188
Sinus tachycardia 28.19 11.13 82 63080 17278 34876491
Bruxism 27.99 11.13 24 63138 1711 34892058
COVID-19 27.62 11.13 62 63100 77488 34816281
Sleep disorder 27.58 11.13 122 63040 31566 34862203
Huntington's disease 27.50 11.13 8 63154 45 34893724
Libido decreased 27.47 11.13 38 63124 4658 34889111
Impulsive behaviour 27.19 11.13 26 63136 2136 34891633
Antidepressant drug level increased 27.17 11.13 10 63152 128 34893641
Social anxiety disorder 26.94 11.13 13 63149 337 34893432
Dissociation 26.88 11.13 23 63139 1635 34892134
Muscle rigidity 26.86 11.13 59 63103 10459 34883310
Interstitial lung disease 26.84 11.13 48 63114 65234 34828535
Affective disorder 26.59 11.13 36 63126 4324 34889445
Memory impairment 26.54 11.13 151 63011 43167 34850602
Cardiac failure 26.36 11.13 81 63081 91167 34802602
Congenital aortic valve stenosis 25.91 11.13 10 63152 147 34893622
Neonatal disorder 25.78 11.13 17 63145 813 34892956
Oculogyric crisis 25.71 11.13 22 63140 1564 34892205
Dystonia 25.64 11.13 59 63103 10786 34882983
Neuropathy peripheral 25.43 11.13 72 63090 83191 34810578
Alcoholism 25.34 11.13 29 63133 2936 34890833
Coma 25.26 11.13 155 63007 45523 34848246
Cyanosis neonatal 25.15 11.13 12 63150 303 34893466
Cardiac arrest 25.10 11.13 275 62887 95884 34797885
Hyperkalaemia 25.10 11.13 55 63107 69334 34824435
Product substitution issue 25.07 11.13 56 63106 10039 34883730
Lethargy 24.96 11.13 143 63019 40979 34852790
Mood altered 24.91 11.13 52 63110 8900 34884869
Gambling disorder 24.84 11.13 22 63140 1638 34892131
Foetal exposure during pregnancy 24.79 11.13 135 63027 37966 34855803
Pleural effusion 24.55 11.13 71 63091 81475 34812294
Renal failure 24.53 11.13 137 63025 130420 34763349
Dreamy state 24.42 11.13 6 63156 15 34893754
Accidental death 24.41 11.13 26 63136 2430 34891339
Physical deconditioning 24.41 11.13 20 63142 1339 34892430
Violence-related symptom 24.37 11.13 14 63148 522 34893247
Feeling jittery 24.33 11.13 33 63129 3970 34889799
Initial insomnia 24.11 11.13 29 63133 3095 34890674
Accommodation disorder 23.72 11.13 11 63151 260 34893509
Restlessness 23.63 11.13 100 63062 25382 34868387
Ascites 23.23 11.13 30 63132 46541 34847228
Herpes zoster 23.13 11.13 17 63145 34382 34859387
Hostility 23.07 11.13 16 63146 832 34892937
Pulmonary embolism 22.96 11.13 84 63078 89662 34804107
Respiratory arrest 22.93 11.13 106 63056 27937 34865832
Tearfulness 22.65 11.13 26 63136 2641 34891128
Neonatal respiratory distress syndrome 22.63 11.13 32 63130 4002 34889767
Prostate cancer 22.53 11.13 23 63139 39626 34854143
Alcohol poisoning 22.42 11.13 30 63132 3563 34890206
Poisoning deliberate 22.34 11.13 46 63116 7798 34885971
Parkinsonism 22.33 11.13 47 63115 8091 34885678
Antisocial behaviour 22.24 11.13 12 63150 395 34893374
Disseminated intravascular coagulation 22.13 11.13 6 63156 21810 34871959
Eye movement disorder 22.07 11.13 32 63130 4095 34889674
Poor quality sleep 21.86 11.13 47 63115 8209 34885560
Emotional disorder 21.84 11.13 38 63124 5678 34888091
Infusion related reaction 21.82 11.13 39 63123 53018 34840751
Erythema 21.47 11.13 85 63077 88695 34805074
Serum serotonin decreased 21.27 11.13 4 63158 0 34893769
Mydriasis 21.27 11.13 43 63119 7194 34886575
Porphyria acute 21.14 11.13 11 63151 336 34893433
Arthralgia 21.04 11.13 201 62961 169840 34723929
Vasoplegia syndrome 20.88 11.13 21 63141 1835 34891934
White blood cell count decreased 20.86 11.13 95 63067 95350 34798419
Neoplasm progression 20.82 11.13 8 63154 23292 34870477
Blunted affect 20.76 11.13 11 63151 349 34893420
Peripheral swelling 20.67 11.13 70 63092 76471 34817298
Vascular stenosis 20.65 11.13 9 63153 183 34893586
Hyperdynamic left ventricle 20.56 11.13 9 63153 185 34893584
Pain 20.50 11.13 254 62908 204421 34689348
Flat affect 20.50 11.13 15 63147 849 34892920
Cytokine release syndrome 20.21 11.13 8 63154 22869 34870900
Obsessive thoughts 19.97 11.13 14 63148 741 34893028
Somnambulism 19.70 11.13 26 63136 3046 34890723
Loss of employment 19.61 11.13 12 63150 503 34893266
Compulsive shopping 19.57 11.13 11 63151 393 34893376
Hypersomnia 19.56 11.13 58 63104 12349 34881420
Treatment failure 19.49 11.13 34 63128 46663 34847106
Negative thoughts 19.41 11.13 13 63149 638 34893131
Agitation neonatal 19.41 11.13 16 63146 1080 34892689
Tachyphrenia 19.35 11.13 17 63145 1252 34892517
Schizophrenia 19.24 11.13 46 63116 8620 34885149
Yawning 19.05 11.13 12 63150 530 34893239
Cataplexy 18.91 11.13 10 63152 316 34893453
Joint swelling 18.87 11.13 51 63111 59839 34833930
Self-injurious ideation 18.85 11.13 19 63143 1665 34892104
Compulsive hoarding 18.78 11.13 5 63157 19 34893750
Cough 18.77 11.13 177 62985 149963 34743806
Hypoglycaemia neonatal 18.67 11.13 20 63142 1881 34891888
Tumour lysis syndrome 18.66 11.13 4 63158 17055 34876714
Compulsions 18.66 11.13 9 63153 233 34893536
Metabolic acidosis 18.63 11.13 139 63023 43541 34850228
Loss of libido 18.58 11.13 23 63139 2529 34891240
Renal ischaemia 18.52 11.13 12 63150 557 34893212
Retinal phototoxicity 18.51 11.13 4 63158 4 34893765
Congenital aortic valve incompetence 18.48 11.13 8 63154 160 34893609
Hypomania 18.37 11.13 22 63140 2337 34891432
Alcohol use 18.33 11.13 26 63136 3262 34890507
Lymphocyte count decreased 18.26 11.13 9 63153 22613 34871156
Gastrointestinal haemorrhage 18.20 11.13 90 63072 88387 34805382
Premature baby 18.16 11.13 77 63085 19556 34874213
Neutrophil count decreased 18.07 11.13 41 63121 51063 34842706
Anaphylactic reaction 18.05 11.13 19 63143 32282 34861487
Dissociative disorder 18.05 11.13 11 63151 458 34893311
Pituitary tumour benign 18.03 11.13 14 63148 867 34892902
Dyspnoea 18.02 11.13 531 62631 376251 34517518
Hyperprolactinaemia 17.85 11.13 18 63144 1578 34892191
Chronic actinic dermatitis 17.68 11.13 5 63157 25 34893744
Haematochezia 17.56 11.13 36 63126 46498 34847271
Small for dates baby 17.54 11.13 28 63134 3899 34889870
Multiple organ dysfunction syndrome 17.46 11.13 75 63087 76491 34817278
Coagulation factor VII level decreased 17.26 11.13 7 63155 118 34893651
Pneumocystis jirovecii pneumonia 17.23 11.13 7 63155 19703 34874066
Colitis 17.15 11.13 26 63136 37724 34856045
Urinary tract discomfort 17.10 11.13 7 63155 121 34893648
C-reactive protein increased 17.10 11.13 46 63116 54052 34839717
Hypersexuality 16.99 11.13 17 63145 1476 34892293
Myocardial infarction 16.78 11.13 139 63023 120946 34772823
Secondary hypogonadism 16.77 11.13 9 63153 293 34893476
Selective mutism 16.72 11.13 6 63156 71 34893698
Tourette's disorder 16.65 11.13 6 63156 72 34893697
Renal artery thrombosis 16.42 11.13 9 63153 306 34893463
Palmar-plantar erythrodysaesthesia syndrome 16.34 11.13 5 63157 16790 34876979
Antipsychotic drug level decreased 16.27 11.13 14 63148 1003 34892766
Feeling guilty 16.21 11.13 9 63153 314 34893455
Pupil fixed 16.04 11.13 18 63144 1783 34891986
Basilar migraine 16.01 11.13 4 63158 11 34893758
Intentional product use issue 15.95 11.13 55 63107 59761 34834008
Muscle necrosis 15.83 11.13 13 63149 873 34892896
Congenital hand malformation 15.66 11.13 11 63151 584 34893185
Feeling abnormal 15.65 11.13 179 62983 63056 34830713
Dysphoria 15.57 11.13 20 63142 2282 34891487
Transposition of the great vessels 15.53 11.13 10 63152 459 34893310
Bone marrow failure 15.48 11.13 18 63144 29235 34864534
Coma uraemic 15.46 11.13 5 63157 42 34893727
Autonomic nervous system imbalance 15.46 11.13 21 63141 2530 34891239
Pruritus 15.43 11.13 173 62989 141808 34751961
Phobia 15.43 11.13 7 63155 157 34893612
Erectile dysfunction 15.42 11.13 76 63086 20561 34873208
Attention deficit hyperactivity disorder 15.41 11.13 21 63141 2538 34891231
Treatment noncompliance 15.31 11.13 95 63067 28005 34865764
Decreased interest 15.18 11.13 20 63142 2340 34891429
Thrombosis 15.13 11.13 44 63118 50414 34843355
Spina bifida 15.09 11.13 9 63153 360 34893409
Hyperbilirubinaemia neonatal 15.08 11.13 12 63150 770 34892999
Creatinine urine decreased 15.06 11.13 5 63157 46 34893723
Condition aggravated 15.03 11.13 454 62708 191742 34702027
Bipolar I disorder 15.02 11.13 12 63150 775 34892994
Bronchopulmonary aspergillosis 14.93 11.13 4 63158 14655 34879114
COVID-19 pneumonia 14.88 11.13 6 63156 16961 34876808
Tension 14.87 11.13 19 63143 2156 34891613
Exposure via ingestion 14.83 11.13 19 63143 2162 34891607
Product prescribing error 14.75 11.13 81 63081 22846 34870923
Logorrhoea 14.74 11.13 20 63142 2406 34891363
Liver disorder 14.72 11.13 23 63139 32974 34860795
Cerebrovascular stenosis 14.70 11.13 6 63156 103 34893666
Blood lactate dehydrogenase increased 14.65 11.13 12 63150 22978 34870791
Haemodynamic instability 14.52 11.13 44 63118 9479 34884290
Eye colour change 14.51 11.13 8 63154 275 34893494
Miosis 14.49 11.13 44 63118 9491 34884278
Respiratory failure 14.43 11.13 126 63036 108446 34785323
Post 5-alpha-reductase inhibitor syndrome 14.34 11.13 6 63156 110 34893659
Blood glucose fluctuation 14.31 11.13 26 63136 4018 34889751
Dysphemia 14.31 11.13 16 63146 1579 34892190
Full blood count abnormal 14.22 11.13 8 63154 18660 34875109
Tongue injury 14.19 11.13 6 63156 113 34893656
Alpha 2 globulin decreased 14.14 11.13 4 63158 20 34893749
Otosalpingitis 14.14 11.13 4 63158 20 34893749
Blood luteinising hormone decreased 14.14 11.13 6 63156 114 34893655
Abdominal distension 14.14 11.13 56 63106 58436 34835333
Hospitalisation 14.06 11.13 54 63108 56848 34836921
Sex hormone binding globulin decreased 13.98 11.13 4 63158 21 34893748
Free androgen index decreased 13.98 11.13 4 63158 21 34893748
Crying 13.98 11.13 32 63130 5830 34887939
Pyloric stenosis 13.92 11.13 12 63150 862 34892907
Blood creatine phosphokinase MB 13.88 11.13 3 63159 3 34893766
Delayed sleep phase 13.88 11.13 3 63159 3 34893766
Androgen insensitivity syndrome 13.83 11.13 4 63158 22 34893747
Viral acanthoma 13.83 11.13 4 63158 22 34893747
Binge eating 13.81 11.13 6 63156 121 34893648
Disorientation 13.80 11.13 105 63057 33083 34860686
Death 13.74 11.13 584 62578 397465 34496304
Suspected suicide 13.70 11.13 28 63134 4720 34889049
Mutism 13.67 11.13 12 63150 883 34892886
Productive cough 13.64 11.13 30 63132 37783 34855986
Oedema 13.63 11.13 40 63122 45701 34848068
Blood creatinine increased 13.63 11.13 108 63054 94868 34798901
Staring 13.63 11.13 15 63147 1455 34892314
Marital problem 13.58 11.13 5 63157 64 34893705
Testicular microlithiasis 13.53 11.13 4 63158 24 34893745
Feeling drunk 13.47 11.13 17 63145 1906 34891863
Blood triglycerides increased 13.46 11.13 56 63106 14103 34879666
Ear discomfort 13.43 11.13 20 63142 2622 34891147
Dehydroepiandrosterone decreased 13.39 11.13 4 63158 25 34893744
Urine calcium/creatinine ratio increased 13.39 11.13 4 63158 25 34893744
Appendicitis 13.37 11.13 5 63157 14802 34878967
Blood bilirubin increased 13.32 11.13 31 63131 38265 34855504
Economic problem 13.28 11.13 14 63148 1293 34892476
Salivary hypersecretion 13.24 11.13 40 63122 8604 34885165
Cognitive disorder 13.20 11.13 93 63069 28600 34865169
Hypertonia neonatal 13.15 11.13 9 63153 458 34893311
Confusional state 13.06 11.13 347 62815 143813 34749956
Hypothalamic pituitary adrenal axis suppression 12.97 11.13 6 63156 141 34893628
Hypogonadism male 12.93 11.13 8 63154 342 34893427
Candida infection 12.92 11.13 8 63154 17707 34876062
Fear 12.90 11.13 45 63117 10431 34883338
Speech disorder 12.86 11.13 85 63077 25601 34868168
Arnold-Chiari malformation 12.85 11.13 8 63154 346 34893423
Hepatic failure 12.79 11.13 27 63135 34504 34859265
Arthropathy 12.74 11.13 18 63144 26889 34866880
Alpha globulin increased 12.67 11.13 3 63159 6 34893763
Wrong drug 12.57 11.13 5 63157 80 34893689
Heart rate abnormal 12.53 11.13 16 63146 1815 34891954
Nausea 12.50 11.13 495 62667 339413 34554356
Cerebral infarction 12.38 11.13 19 63143 27436 34866333
Haemophagocytic lymphohistiocytosis 12.37 11.13 4 63158 12969 34880800
Bone marrow oedema 12.30 11.13 10 63152 662 34893107
Drooling 12.30 11.13 22 63140 3360 34890409
Myelodysplastic syndrome 12.27 11.13 10 63152 19198 34874571
Testis cancer 12.25 11.13 14 63148 1415 34892354
Cyclothymic disorder 12.13 11.13 5 63157 88 34893681
Atrial septal defect 12.08 11.13 35 63127 7357 34886412
Thought insertion 12.07 11.13 3 63159 8 34893761
Drug reaction with eosinophilia and systemic symptoms 12.07 11.13 26 63136 32986 34860783
Locked-in syndrome 12.01 11.13 7 63155 268 34893501
Self esteem decreased 11.99 11.13 9 63153 530 34893239
Panic disorder 11.98 11.13 13 63149 1241 34892528
Bradycardia 11.91 11.13 197 62965 75221 34818548
Sleep apnoea syndrome 11.89 11.13 70 63092 20251 34873518
Panic reaction 11.89 11.13 14 63148 1461 34892308
Mental status changes 11.88 11.13 113 63049 37970 34855799
Neutropenic sepsis 11.86 11.13 5 63157 13762 34880007
Psychiatric symptom 11.70 11.13 22 63140 3491 34890278
Abnormal loss of weight 11.66 11.13 24 63138 4066 34889703
Chronic kidney disease 11.60 11.13 37 63125 41173 34852596
Therapeutic product effect incomplete 11.59 11.13 141 63021 50400 34843369
Carbon monoxide poisoning 11.55 11.13 5 63157 100 34893669
Ankyloglossia congenital 11.52 11.13 7 63155 290 34893479
Urinary retention 11.48 11.13 108 63054 36180 34857589
Water intoxication 11.47 11.13 8 63154 420 34893349
Drug intolerance 11.45 11.13 62 63100 59508 34834261
Mixed delusion 11.41 11.13 4 63158 44 34893725
Dyspnoea exertional 11.40 11.13 40 63122 43239 34850530
Retrograde ejaculation 11.38 11.13 8 63154 425 34893344
Multiple sclerosis 11.38 11.13 32 63130 6613 34887156
Coordination abnormal 11.36 11.13 35 63127 7609 34886160
Genital anaesthesia 11.35 11.13 3 63159 11 34893758
Thyroxine free abnormal 11.35 11.13 3 63159 11 34893758
Cardiac failure congestive 11.35 11.13 96 63066 83174 34810595
Cortisol increased 11.33 11.13 6 63156 190 34893579
Therapeutic response unexpected 11.24 11.13 41 63121 9716 34884053
Gastric hypomotility 11.20 11.13 5 63157 108 34893661
Urine phosphorus decreased 11.18 11.13 4 63158 47 34893722

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2158.64 9.71 2636 167475 243131 79331146
Serotonin syndrome 1420.23 9.71 991 169120 44036 79530241
Toxicity to various agents 1297.17 9.71 2806 167305 418734 79155543
Intentional overdose 1288.86 9.71 1348 168763 104612 79469665
Suicidal ideation 1055.30 9.71 1041 169070 75299 79498978
Suicide attempt 785.31 9.71 926 169185 82006 79492271
Drug interaction 776.93 9.71 2290 167821 412893 79161384
Drug abuse 668.05 9.71 1224 168887 161467 79412810
Intentional self-injury 566.76 9.71 504 169607 31915 79542362
Electrocardiogram QT prolonged 487.22 9.71 768 169343 89618 79484659
Overdose 405.25 9.71 1079 169032 183127 79391150
Anxiety 353.89 9.71 1250 168861 247262 79327015
Tremor 351.75 9.71 974 169137 169109 79405168
Agitation 340.07 9.71 694 169417 99021 79475256
Depression 301.30 9.71 1082 169029 215708 79358569
Drug withdrawal syndrome 297.90 9.71 369 169742 34349 79539928
Respiratory arrest 290.82 9.71 475 169636 57075 79517202
Poisoning 286.37 9.71 310 169801 24962 79549315
Cardiac arrest 277.70 9.71 903 169208 171193 79403084
Cardio-respiratory arrest 270.93 9.71 667 169444 107843 79466434
Synovitis 260.85 9.71 15 170096 150719 79423558
Akathisia 257.63 9.71 219 169892 13040 79561237
Febrile neutropenia 240.21 9.71 96 170015 230903 79343374
Torsade de pointes 222.50 9.71 239 169872 19073 79555204
Irritability 222.10 9.71 350 169761 40794 79533483
Aggression 219.73 9.71 392 169719 50566 79523711
Contraindicated product administered 213.33 9.71 39 170072 157499 79416778
Withdrawal syndrome 202.93 9.71 268 169843 26586 79547691
Hand deformity 197.86 9.71 5 170106 103914 79470363
Joint swelling 197.05 9.71 195 169916 288451 79285826
Infusion related reaction 191.41 9.71 128 169983 230109 79344168
Depressed mood 187.68 9.71 356 169755 48124 79526153
Suicidal behaviour 187.41 9.71 105 170006 3142 79571135
Obsessive-compulsive disorder 185.64 9.71 130 169981 5797 79568480
Somnolence 184.25 9.71 1000 169111 237981 79336296
Reversible cerebral vasoconstriction syndrome 182.29 9.71 101 170010 2956 79571321
Poisoning deliberate 179.28 9.71 211 169900 18617 79555660
Systemic lupus erythematosus 170.61 9.71 27 170084 121122 79453155
Pericarditis 167.04 9.71 15 170096 104221 79470056
Rheumatoid arthritis 162.65 9.71 124 169987 208346 79365931
Pneumonia 159.32 9.71 796 169315 659450 78914827
Respiratory depression 158.84 9.71 242 169869 27388 79546889
Tardive dyskinesia 158.73 9.71 151 169960 10420 79563857
Drug intolerance 156.67 9.71 200 169911 263919 79310358
Mania 151.70 9.71 191 169920 18069 79556208
Coma 151.42 9.71 516 169595 100133 79474144
Drug dependence 143.94 9.71 288 169823 40481 79533796
Rash 141.33 9.71 694 169417 577664 78996613
Disturbance in attention 140.45 9.71 325 169786 50476 79523801
Infection 140.29 9.71 186 169925 241526 79332751
Seizure 139.99 9.71 782 169329 188052 79386225
Sopor 139.81 9.71 252 169859 32758 79541519
Treatment failure 134.78 9.71 100 170011 170386 79403891
Peripheral swelling 134.69 9.71 230 169881 269387 79304890
Electrocardiogram QRS complex prolonged 133.55 9.71 139 169972 10694 79563583
Wound 131.40 9.71 42 170069 116137 79458140
General physical health deterioration 131 9.71 242 169869 274996 79299281
Anaemia 130.63 9.71 498 169613 444517 79129760
Mydriasis 130.10 9.71 174 169937 17469 79556808
Panic attack 129.29 9.71 205 169906 24011 79550266
Nightmare 128.64 9.71 212 169899 25649 79548628
Pyrexia 128.64 9.71 884 169227 677825 78896452
Arthropathy 128.63 9.71 113 169998 176998 79397279
Intentional product misuse 117.84 9.71 458 169653 94707 79479570
Swelling 117.54 9.71 175 169936 216536 79357741
Generalised tonic-clonic seizure 116.02 9.71 276 169835 43634 79530643
Helicobacter infection 114.51 9.71 9 170102 69695 79504582
Malignant neoplasm progression 113.78 9.71 75 170036 135915 79438362
Muscle twitching 111.25 9.71 194 169917 24570 79549707
Homicide 110.77 9.71 53 170058 1133 79573144
Rheumatoid factor positive 109.84 9.71 4 170107 59835 79514442
Abnormal behaviour 109.59 9.71 241 169870 36180 79538097
Thrombocytopenia 108.69 9.71 254 169857 265005 79309272
Arthralgia 108.13 9.71 745 169366 571058 79003219
Disease progression 106.81 9.71 142 169969 184220 79390057
Euphoric mood 105.94 9.71 105 170006 7621 79566656
Muscle rigidity 105.72 9.71 168 169943 19714 79554563
Crying 105.45 9.71 182 169929 22861 79551416
Extrapyramidal disorder 104.93 9.71 180 169931 22499 79551778
Off label use 104.89 9.71 1337 168774 905878 78668399
Platelet count decreased 104.78 9.71 158 169953 194506 79379771
Hepatic enzyme increased 103.42 9.71 143 169968 182467 79391810
Alopecia 102.62 9.71 212 169899 231143 79343134
Neutropenia 102.19 9.71 296 169815 287414 79286863
Pancytopenia 101.91 9.71 122 169989 165623 79408654
Therapeutic product effect decreased 101.41 9.71 120 169991 163743 79410534
Dyskinesia 97.98 9.71 262 169849 44511 79529766
Dystonia 97.90 9.71 169 169942 21230 79553047
Restless legs syndrome 97.64 9.71 163 169948 19929 79554348
Sedation 96.25 9.71 286 169825 51609 79522668
Paranoia 96.25 9.71 159 169952 19273 79555004
Galactorrhoea 96.02 9.71 72 170039 3574 79570703
Myoclonus 95.97 9.71 194 169917 27466 79546811
Duodenal ulcer perforation 94.93 9.71 14 170097 66197 79508080
Stomatitis 94.58 9.71 104 170007 146653 79427624
Glossodynia 93.42 9.71 52 170059 103285 79470992
Hyperreflexia 90.02 9.71 100 170011 8285 79565992
Abdominal discomfort 88.26 9.71 259 169852 250468 79323809
Depressed level of consciousness 88.02 9.71 424 169687 96228 79478049
Tic 87.75 9.71 63 170048 2923 79571354
Self-injurious ideation 87.36 9.71 68 170043 3570 79570707
Anger 87.12 9.71 142 169969 17020 79557257
Coma scale abnormal 85.53 9.71 99 170012 8579 79565698
Hallucination, auditory 85.12 9.71 156 169955 20537 79553740
Renal impairment 84.00 9.71 129 169982 157654 79416623
Hyperhidrosis 83.76 9.71 582 169529 150910 79423367
Restlessness 82.24 9.71 252 169859 46240 79528037
Nasopharyngitis 81.78 9.71 273 169838 253608 79320669
Clonus 81.16 9.71 86 170025 6754 79567523
Sepsis 79.92 9.71 300 169811 269128 79305149
C-reactive protein increased 79.28 9.71 95 170016 128932 79445345
Disinhibition 79.08 9.71 56 170055 2542 79571735
Folliculitis 78.73 9.71 12 170099 55368 79518909
Psychotic disorder 77.56 9.71 229 169882 41173 79533104
Bezoar 77.36 9.71 56 170055 2632 79571645
Acute kidney injury 76.79 9.71 723 169388 518681 79055596
Mucosal inflammation 75.93 9.71 33 170078 75547 79498730
Tearfulness 75.30 9.71 78 170033 5967 79568310
Miosis 75.27 9.71 127 169984 15662 79558615
Atrial fibrillation 75.14 9.71 197 169914 197689 79376588
Parkinsonism 74.60 9.71 130 169981 16454 79557823
Abnormal dreams 74.31 9.71 106 170005 11306 79562971
Blister 73.37 9.71 88 170023 119388 79454889
Sleep disorder due to general medical condition, insomnia type 73.33 9.71 5 170106 43551 79530726
Diarrhoea 72.05 9.71 1385 168726 879104 78695173
Mood swings 72.04 9.71 142 169969 19738 79554539
Lower respiratory tract infection 71.35 9.71 103 170008 129117 79445160
Intentional product use issue 71.20 9.71 135 169976 151977 79422300
Drug ineffective 70.74 9.71 1762 168349 1079151 78495126
Muscle injury 70.24 9.71 10 170101 48551 79525726
C-reactive protein abnormal 69.86 9.71 10 170101 48357 79525920
Impulsive behaviour 69.19 9.71 54 170057 2846 79571431
Antipsychotic drug level increased 69.10 9.71 74 170037 5883 79568394
Product substitution issue 69.00 9.71 141 169970 20115 79554162
Accidental death 67.69 9.71 63 170048 4228 79570049
Impaired healing 65.97 9.71 54 170057 87601 79486676
Mental disorder 65.31 9.71 180 169931 31122 79543155
Mobility decreased 63.96 9.71 101 170010 122074 79452203
Discomfort 63.74 9.71 106 170005 125511 79448766
Cytomegalovirus infection 63.54 9.71 8 170103 42636 79531641
Insomnia 61.98 9.71 797 169314 244373 79329904
Drug abuser 61.62 9.71 70 170041 5943 79568334
Cardiac failure 61.21 9.71 151 169960 154691 79419586
Hypersensitivity 60.28 9.71 321 169790 261918 79312359
Hostility 59.46 9.71 45 170066 2265 79572012
Mood altered 59.34 9.71 123 169988 17724 79556553
Myelosuppression 58.98 9.71 8 170103 40288 79533989
Product complaint 57.92 9.71 103 170008 13246 79561031
Sinus bradycardia 57.53 9.71 150 169961 25097 79549180
Apathy 57.42 9.71 101 170010 12876 79561401
Homicidal ideation 56.95 9.71 52 170059 3405 79570872
Social avoidant behaviour 56.19 9.71 60 170051 4754 79569523
Emotional distress 55.82 9.71 200 169911 39769 79534508
Dissociation 55.78 9.71 55 170056 3966 79570311
Victim of child abuse 55.50 9.71 31 170080 922 79573355
Choreoathetosis 55.24 9.71 37 170074 1533 79572744
Septic shock 54.86 9.71 112 169999 122689 79451588
Cholecystitis chronic 54.45 9.71 85 170026 9821 79564456
Drug level increased 54.18 9.71 197 169914 39454 79534823
Confusional state 54.08 9.71 966 169145 317031 79257246
Myocardial depression 53.58 9.71 25 170086 504 79573773
Sinus tachycardia 53.53 9.71 187 169924 36721 79537556
Pain 53.29 9.71 1121 168990 702681 78871596
Hallucination 53.15 9.71 339 169772 85406 79488871
Psychomotor hyperactivity 52.40 9.71 113 169998 16736 79557541
Blood prolactin increased 52.21 9.71 53 170058 3958 79570319
Neuroleptic malignant syndrome 52.16 9.71 153 169958 27406 79546871
Libido increased 51.55 9.71 39 170072 1962 79572315
Speech disorder 51.11 9.71 241 169870 54204 79520073
Blood creatinine increased 51.10 9.71 165 169946 154892 79419385
Decorticate posture 50.29 9.71 21 170090 321 79573956
Increased appetite 50.15 9.71 91 170020 11887 79562390
Feeling abnormal 49.70 9.71 539 169572 158660 79415617
Dyspnoea 49.39 9.71 1422 168689 855603 78718674
Nervousness 49.07 9.71 170 169941 33245 79541032
Thinking abnormal 48.89 9.71 95 170016 13066 79561211
Stress cardiomyopathy 48.24 9.71 86 170025 11080 79563197
Haemoglobin decreased 48.24 9.71 277 169834 221842 79352435
Suspected suicide 47.69 9.71 83 170028 10493 79563784
Memory impairment 47.61 9.71 404 169707 111330 79462947
Neuropathy peripheral 47.52 9.71 149 169962 141156 79433121
Fear 47.43 9.71 128 169983 21858 79552419
Persistent genital arousal disorder 47.27 9.71 19 170092 262 79574015
Hyperprolactinaemia 47.18 9.71 54 170057 4622 79569655
Tachycardia 47.08 9.71 583 169528 177185 79397092
Dependence 47.04 9.71 40 170071 2382 79571895
Inappropriate antidiuretic hormone secretion 46.88 9.71 143 169968 26170 79548107
Hepatic function abnormal 46.87 9.71 52 170059 73055 79501222
Multiple sclerosis 46.35 9.71 128 169983 22154 79552123
Pleural effusion 46.20 9.71 157 169954 145105 79429172
Oculogyric crisis 45.91 9.71 43 170068 2909 79571368
Herpes zoster 45.88 9.71 80 170031 93003 79481274
Antipsychotic drug level below therapeutic 45.55 9.71 30 170081 1208 79573069
Gastrointestinal disorder 45.35 9.71 123 169988 122082 79452195
Product use issue 44.85 9.71 263 169848 209559 79364718
Long QT syndrome 44.32 9.71 59 170052 5896 79568381
Cough 43.86 9.71 536 169575 366253 79208024
Morbid thoughts 43.76 9.71 25 170086 777 79573500
Bradyphrenia 43.49 9.71 80 170031 10560 79563717
Parasomnia 43.25 9.71 22 170089 539 79573738
Arthritis 43.11 9.71 115 169996 114765 79459512
Erythema 43.02 9.71 289 169822 223001 79351276
Alcoholism 42.75 9.71 46 170065 3677 79570600
Neoplasm progression 42.54 9.71 29 170082 51653 79522624
Ill-defined disorder 42.07 9.71 47 170064 65828 79508449
Synaesthesia 41.22 9.71 8 170103 0 79574277
Major depression 41.18 9.71 71 170040 8909 79565368
Epidural lipomatosis 40.96 9.71 28 170083 1200 79573077
Blood hyposmosis 40.92 9.71 10 170101 19 79574258
Cerebral vasoconstriction 40.89 9.71 30 170081 1440 79572837
Physical assault 40.62 9.71 31 170080 1580 79572697
Poor quality sleep 40.03 9.71 123 169988 22599 79551678
Bruxism 39.79 9.71 46 170065 3980 79570297
Blood pressure fluctuation 39.59 9.71 51 170060 67094 79507183
Rhabdomyolysis 39.35 9.71 364 169747 102767 79471510
Drug hypersensitivity 39.15 9.71 428 169683 298488 79275789
Hyperkalaemia 38.90 9.71 120 169991 114278 79459999
Catatonia 38.55 9.71 68 170043 8688 79565589
Atrioventricular block first degree 37.96 9.71 83 170028 12408 79561869
Blood lactate dehydrogenase increased 37.94 9.71 18 170093 39152 79535125
Alcohol poisoning 37.79 9.71 49 170062 4772 79569505
Libido decreased 36.99 9.71 51 170060 5270 79569007
Heart sounds 36.98 9.71 24 170087 942 79573335
Eye movement disorder 36.29 9.71 63 170048 7948 79566329
Yawning 36.03 9.71 27 170084 1339 79572938
Anorgasmia 35.80 9.71 26 170085 1228 79573049
White blood cell count decreased 35.62 9.71 245 169866 188043 79386234
Obsessive-compulsive symptom 35.57 9.71 14 170097 182 79574095
Ascites 35.40 9.71 67 170044 75495 79498782
Cogwheel rigidity 35.18 9.71 38 170073 3050 79571227
Red blood cell sedimentation rate increased 34.94 9.71 28 170083 45914 79528363
Feeling guilty 34.30 9.71 22 170089 846 79573431
Bone marrow failure 34.27 9.71 35 170076 51072 79523205
Prostate cancer 34.25 9.71 14 170097 33254 79541023
Unresponsive to stimuli 34.22 9.71 220 169891 55568 79518709
Flat affect 34.21 9.71 31 170080 2010 79572267
Cytokine release syndrome 34.17 9.71 17 170094 35981 79538296
Huntington's disease 33.91 9.71 8 170103 12 79574265
Marital problem 33.76 9.71 14 170097 210 79574067
Soft tissue injury 33.74 9.71 29 170082 1752 79572525
Traumatic coma 33.71 9.71 10 170101 50 79574227
Derealisation 33.60 9.71 28 170083 1621 79572656
Inflammation 33.57 9.71 96 170015 93657 79480620
Musculoskeletal stiffness 33.46 9.71 227 169884 174781 79399496
Emotional disorder 33.31 9.71 86 170025 14301 79559976
Affective disorder 33.31 9.71 62 170049 8257 79566020
Reduced facial expression 33.23 9.71 35 170076 2730 79571547
Bipolar I disorder 33.09 9.71 31 170080 2098 79572179
Panic reaction 32.86 9.71 45 170066 4620 79569657
Bipolar disorder 32.84 9.71 59 170052 7648 79566629
Accidental overdose 32.73 9.71 169 169942 39412 79534865
Delusion 32.72 9.71 107 170004 20316 79553961
Violence-related symptom 32.59 9.71 20 170091 711 79573566
Lethargy 32.57 9.71 290 169821 81002 79493275
Hip arthroplasty 32.29 9.71 18 170093 35738 79538539
Hallucination, visual 32.28 9.71 147 169964 32582 79541695
Therapeutic product effect incomplete 32.18 9.71 174 169937 141471 79432806
Pulseless electrical activity 32.13 9.71 84 170027 14076 79560201
Metabolic acidosis 31.84 9.71 292 169819 82237 79492040
Bone marrow oedema syndrome 31.58 9.71 9 170102 38 79574239
Abnormal sleep-related event 31.39 9.71 21 170090 868 79573409
Multiple sclerosis relapse 31.36 9.71 188 169923 46345 79527932
Asphyxia 31.31 9.71 74 170037 11646 79562631
Respiration abnormal 31.13 9.71 58 170053 7730 79566547
Prolonged expiration 31.05 9.71 24 170087 1247 79573030
Staring 30.93 9.71 33 170078 2612 79571665
Mental impairment 30.74 9.71 100 170011 18936 79555341
Therapeutic product effect variable 30.74 9.71 29 170082 1980 79572297
Liver disorder 30.70 9.71 68 170043 72349 79501928
Dysarthria 30.13 9.71 247 169864 67375 79506902
Weight increased 29.86 9.71 789 169322 276597 79297680
Cystostomy 29.51 9.71 10 170101 82 79574195
Dysphoria 29.40 9.71 43 170068 4691 79569586
Irritable bowel syndrome 29.32 9.71 55 170056 62186 79512091
Social anxiety disorder 29.03 9.71 17 170094 554 79573723
Obsessive thoughts 29.02 9.71 22 170089 1110 79573167
Negative thoughts 29.02 9.71 24 170087 1375 79572902
Sinusitis 28.86 9.71 272 169839 195229 79379048
Tension 28.81 9.71 41 170070 4363 79569914
Hypomania 28.69 9.71 55 170056 7489 79566788
Hypersomnia 28.47 9.71 111 170000 22975 79551302
Depressive symptom 28.43 9.71 50 170061 6373 79567904
Multiple organ dysfunction syndrome 28.27 9.71 146 169965 120100 79454177
Borderline personality disorder 28.26 9.71 20 170091 907 79573370
Blood bilirubin increased 28.24 9.71 62 170049 66170 79508107
Dysphemia 28.23 9.71 36 170075 3448 79570829
Basilar migraine 28.17 9.71 9 170102 60 79574217
Self-medication 28.16 9.71 44 170067 5088 79569189
Breast discomfort 28.03 9.71 15 170096 409 79573868
Tachyphrenia 28.02 9.71 28 170083 2052 79572225
Amnesia 27.92 9.71 230 169881 62827 79511450
Visceral congestion 27.70 9.71 20 170091 936 79573341
Migraine 27.65 9.71 297 169814 87196 79487081
Aspergillus infection 27.58 9.71 4 170107 19157 79555120
Neutrophil count decreased 27.58 9.71 105 170006 93854 79480423
Complication of device insertion 27.55 9.71 49 170062 6301 79567976
Carbon monoxide poisoning 27.42 9.71 13 170098 272 79574005
Eosinophilic pneumonia acute 27.41 9.71 21 170090 1077 79573200
Thrombotic microangiopathy 27.27 9.71 5 170106 20164 79554113
Antidepressant drug level increased 27.13 9.71 15 170096 437 79573840
Loss of libido 27.08 9.71 31 170080 2654 79571623
Obesity 27.01 9.71 147 169964 34978 79539299
Hyponatraemia 26.98 9.71 531 169580 177317 79396960
Initial insomnia 26.90 9.71 51 170060 6887 79567390
Depersonalisation/derealisation disorder 26.82 9.71 26 170085 1836 79572441
Influenza like illness 26.80 9.71 252 169859 71455 79502822
Musculoskeletal pain 26.54 9.71 120 169991 102234 79472043
Tumour lysis syndrome 26.45 9.71 9 170102 23930 79550347
Urinary incontinence 26.12 9.71 163 169948 40746 79533531
Formication 26.09 9.71 42 170069 4981 79569296
Somnambulism 25.93 9.71 45 170066 5676 79568601
Transplant rejection 25.89 9.71 5 170106 19432 79554845
Oxygen saturation decreased 25.86 9.71 165 169946 128882 79445395
Blunted affect 25.81 9.71 15 170096 482 79573795
Joint range of motion decreased 25.67 9.71 20 170091 33262 79541015
Oedema 25.48 9.71 150 169961 119430 79454847
Palmar-plantar erythrodysaesthesia syndrome 25.44 9.71 20 170091 33114 79541163
Coordination abnormal 25.35 9.71 88 170023 17224 79557053
Heart rate decreased 25.17 9.71 72 170039 70244 79504033
Sternal fracture 25.16 9.71 29 170082 2501 79571776
Decreased interest 25.05 9.71 35 170076 3662 79570615
Psoriatic arthropathy 24.99 9.71 84 170027 77915 79496362
Bacteraemia 24.97 9.71 20 170091 32804 79541473
Treatment noncompliance 24.97 9.71 194 169917 52074 79522203
Attention deficit hyperactivity disorder 24.96 9.71 33 170078 3276 79571001
Disorientation 24.66 9.71 223 169888 62553 79511724
Self esteem decreased 24.65 9.71 19 170092 983 79573294
Swollen tongue 24.36 9.71 165 169946 42405 79531872
Blood lactic acid decreased 24.36 9.71 12 170099 274 79574003
Foetal arrhythmia 24.34 9.71 8 170103 59 79574218
Knee arthroplasty 24.33 9.71 34 170077 43214 79531063
Burning mouth syndrome 24.32 9.71 15 170096 538 79573739
Jaundice neonatal 24.30 9.71 10 170101 147 79574130
Alcohol interaction 24.29 9.71 40 170071 4834 79569443
Foetal exposure during pregnancy 24.25 9.71 44 170067 5746 79568531
Drug screen positive 24.04 9.71 45 170066 6018 79568259
Loss of consciousness 24.00 9.71 497 169614 167446 79406831
Protein C increased 23.98 9.71 9 170102 102 79574175
Priapism 23.85 9.71 38 170073 4467 79569810
Posture abnormal 23.84 9.71 35 170076 3831 79570446
Anterograde amnesia 23.63 9.71 16 170095 675 79573602
Device placement issue 23.58 9.71 20 170091 1187 79573090
Polyneuropathy 23.54 9.71 11 170100 24140 79550137
Blood pressure diastolic decreased 23.50 9.71 18 170093 30198 79544079
Compulsive shopping 23.48 9.71 17 170094 799 79573478
Sleep-related eating disorder 23.15 9.71 16 170095 698 79573579
Serum serotonin decreased 23.15 9.71 6 170105 16 79574261
Diet failure 23.12 9.71 7 170104 38 79574239
Ventricular hypokinesia 23.09 9.71 57 170054 9222 79565055
Hypertonia 23.06 9.71 49 170062 7183 79567094
Acute respiratory distress syndrome 22.99 9.71 167 169944 43900 79530377
Haematotoxicity 22.91 9.71 3 170108 15516 79558761
Grip strength decreased 22.85 9.71 9 170102 21860 79552417
Hyporesponsive to stimuli 22.58 9.71 25 170086 2063 79572214
Trichotillomania 22.46 9.71 10 170101 180 79574097
Serum sickness-like reaction 22.42 9.71 15 170096 620 79573657
Disseminated intravascular coagulation 22.42 9.71 26 170085 35816 79538461
Child abuse 22.41 9.71 13 170098 416 79573861
Bulimia nervosa 22.34 9.71 11 170100 251 79574026
Therapeutic response unexpected 22.28 9.71 93 170018 19853 79554424
Fibromyalgia 22.22 9.71 67 170044 64273 79510004
Oral discharge 22.10 9.71 11 170100 257 79574020
Pneumocystis jirovecii pneumonia 22.10 9.71 22 170089 32486 79541791
Alcohol use 21.89 9.71 38 170073 4793 79569484
Sexual dysfunction 21.82 9.71 50 170061 7713 79566564
Blood pressure measurement 21.76 9.71 13 170098 440 79573837
Autonomic nervous system imbalance 21.75 9.71 37 170074 4593 79569684
Respiratory disorder 21.69 9.71 39 170072 44817 79529460
Gastrointestinal haemorrhage 21.59 9.71 206 169905 147513 79426764
Blood pressure systolic increased 21.56 9.71 72 170039 66914 79507363
Sluggishness 21.50 9.71 45 170066 6527 79567750
COVID-19 pneumonia 21.42 9.71 18 170093 28831 79545446
Analgesic drug level increased 21.40 9.71 30 170081 3148 79571129
Bursitis 21.36 9.71 27 170084 35817 79538460
Panic disorder 21.28 9.71 29 170082 2963 79571314
Exposure via ingestion 21.27 9.71 39 170072 5135 79569142
Hospitalisation 21.27 9.71 116 169995 94120 79480157
Chorea 21.22 9.71 26 170085 2391 79571886
Cholinergic syndrome 21.21 9.71 18 170093 1069 79573208
Personality disorder 21.19 9.71 43 170068 6103 79568174
Stress 21.01 9.71 261 169850 79351 79494926
Single umbilical artery 21.00 9.71 5 170106 8 79574269
Economic problem 20.88 9.71 25 170086 2245 79572032
Pruritus 20.85 9.71 662 169449 393986 79180291
Post-traumatic neck syndrome 20.82 9.71 24 170087 2070 79572207
Colitis 20.82 9.71 83 170028 73224 79501053
Dreamy state 20.81 9.71 7 170104 56 79574221
Oedema peripheral 20.76 9.71 396 169715 251892 79322385
Pathogen resistance 20.63 9.71 3 170108 14339 79559938
Agitation neonatal 20.61 9.71 4 170107 0 79574277
Binge eating 20.36 9.71 13 170098 496 79573781
Hypoalbuminaemia 20.30 9.71 10 170101 21287 79552990
Ideas of reference 20.27 9.71 9 170102 161 79574116
Heart rate 20.19 9.71 8 170103 106 79574171
Loss of personal independence in daily activities 20.13 9.71 132 169979 102448 79471829
Patent ductus arteriosus 20.12 9.71 8 170103 107 79574170
Hyperthermia 20.07 9.71 84 170027 17953 79556324
Hallucinations, mixed 20.01 9.71 45 170066 6854 79567423
Serum ferritin abnormal 19.96 9.71 12 170099 411 79573866
Thought insertion 19.91 9.71 6 170105 32 79574245
Appetite disorder 19.74 9.71 48 170063 7691 79566586
Graft versus host disease 19.73 9.71 4 170107 15022 79559255
Haematochezia 19.71 9.71 108 170003 87537 79486740
Drug eruption 19.67 9.71 40 170071 43895 79530382
Genital anaesthesia 19.67 9.71 5 170106 12 79574265
Osteonecrosis of jaw 19.66 9.71 39 170072 43187 79531090
Phobia 19.62 9.71 12 170099 424 79573853
Feeling of despair 19.55 9.71 27 170084 2794 79571483
Vision blurred 19.51 9.71 326 169785 105572 79468705
Breath sounds abnormal 19.50 9.71 5 170106 15979 79558298
CYP3A4 polymorphism 19.43 9.71 7 170104 70 79574207
Pulmonary haemosiderosis 19.38 9.71 5 170106 13 79574264
Cataplexy 19.33 9.71 16 170095 918 79573359
Bronchopulmonary aspergillosis 19.04 9.71 12 170099 22282 79551995
Hypercalcaemia 18.96 9.71 33 170078 38397 79535880
IIIrd nerve paresis 18.95 9.71 9 170102 189 79574088
Breast enlargement 18.89 9.71 20 170091 1569 79572708
Amenorrhoea 18.87 9.71 47 170064 7645 79566632
Bladder cancer 18.87 9.71 9 170102 19517 79554760
Liver function test increased 18.86 9.71 35 170076 39738 79534539
Agoraphobia 18.86 9.71 13 170098 565 79573712
Proteinuria 18.84 9.71 25 170086 32477 79541800
Enterocolitis 18.77 9.71 4 170107 14508 79559769
Mental status changes 18.75 9.71 222 169889 66737 79507540
Tenosynovitis 18.72 9.71 5 170106 15549 79558728
Tubulointerstitial nephritis 18.71 9.71 33 170078 38202 79536075
Psychomotor retardation 18.69 9.71 41 170070 6143 79568134
Feeling drunk 18.68 9.71 35 170076 4684 79569593
Anhedonia 18.67 9.71 72 170039 14826 79559451
Induced abortion failed 18.62 9.71 9 170102 197 79574080
Accommodation disorder 18.46 9.71 13 170098 585 79573692
Juvenile idiopathic arthritis 18.45 9.71 35 170076 4728 79569549
Depression suicidal 18.44 9.71 31 170080 3811 79570466
Angle closure glaucoma 18.44 9.71 27 170084 2949 79571328
Anaphylactic reaction 18.40 9.71 104 170007 83639 79490638
Urinary retention 18.24 9.71 193 169918 56437 79517840
Dermatitis atopic 18.24 9.71 55 170056 10001 79564276
Concussion 18.21 9.71 53 170058 9450 79564827
Pseudomonas infection 18.20 9.71 11 170100 20892 79553385
Blood urea increased 18.18 9.71 49 170062 48741 79525536
Gambling disorder 18.13 9.71 22 170089 2004 79572273
Oesophageal food impaction 18.10 9.71 11 170100 384 79573893
Dermatillomania 18.05 9.71 9 170102 211 79574066
Bradycardia 18.02 9.71 397 169714 135160 79439117
Retinal phototoxicity 17.85 9.71 4 170107 4 79574273
Prescribed underdose 17.83 9.71 22 170089 29492 79544785
Resting tremor 17.83 9.71 19 170092 1502 79572775
Agranulocytosis 17.71 9.71 44 170067 44986 79529291
Gallbladder disorder 17.70 9.71 85 170026 19255 79555022
Neutropenic sepsis 17.62 9.71 19 170092 27045 79547232
Posterior reversible encephalopathy syndrome 17.62 9.71 18 170093 26263 79548014
Ventricular arrhythmia 17.62 9.71 50 170061 8790 79565487
Chronic actinic dermatitis 17.56 9.71 5 170106 21 79574256
Drooling 17.55 9.71 39 170072 5895 79568382
Incubator therapy 17.52 9.71 6 170105 51 79574226
Pupil fixed 17.42 9.71 29 170082 3537 79570740
Neonatal seizure 17.38 9.71 4 170107 5 79574272
Cytopenia 17.37 9.71 11 170100 20372 79553905
Diverticulitis 17.21 9.71 46 170065 45890 79528387
Pituitary tumour benign 16.88 9.71 24 170087 2552 79571725
Constipation 16.88 9.71 467 169644 282583 79291694
Myelodysplastic syndrome 16.87 9.71 24 170087 30277 79544000
Dehydroepiandrosterone decreased 16.86 9.71 5 170106 25 79574252
Peritonitis 16.83 9.71 21 170090 28015 79546262
Narcolepsy 16.75 9.71 17 170094 1269 79573008
Blood uric acid increased 16.65 9.71 4 170107 13356 79560921
Sleep disorder 16.61 9.71 266 169845 85411 79488866
Blood pressure systolic abnormal 16.59 9.71 8 170103 17239 79557038
Cholecystectomy 16.56 9.71 51 170060 9381 79564896
Salivary hypersecretion 16.42 9.71 67 170044 14157 79560120
Supraventricular tachyarrhythmia 16.42 9.71 7 170104 113 79574164
Balance disorder 16.30 9.71 299 169812 98558 79475719
Fatigue 16.28 9.71 1736 168375 927991 78646286
Hypersexuality 16.28 9.71 19 170092 1661 79572616
Cardiac failure congestive 16.27 9.71 210 169901 142192 79432085
Product use in unapproved indication 16.26 9.71 408 169703 249951 79324326
Secondary hypogonadism 16.21 9.71 10 170101 359 79573918
Acute myopia 16.20 9.71 7 170104 117 79574160
Electrocardiogram repolarisation abnormality 16.17 9.71 22 170089 2245 79572032
Foetal monitoring abnormal 16.11 9.71 8 170103 186 79574091
Basal cell carcinoma 15.92 9.71 35 170076 37340 79536937
Vaginal haemorrhage 15.90 9.71 90 170021 21727 79552550
Confabulation 15.77 9.71 11 170100 487 79573790
Myocardial infarction 15.76 9.71 287 169824 183842 79390435
Haemophagocytic lymphohistiocytosis 15.76 9.71 14 170097 21823 79552454
Cytomegalovirus viraemia 15.66 9.71 4 170107 12817 79561460
Thrombosis 15.61 9.71 110 170001 83990 79490287
Logorrhoea 15.60 9.71 31 170080 4334 79569943
Eating disorder 15.50 9.71 86 170025 20611 79553666
Sleep paralysis 15.48 9.71 12 170099 626 79573651
Cerebral infarction 15.46 9.71 48 170063 45628 79528649
Selective mutism 15.46 9.71 6 170105 75 79574202
Sudden onset of sleep 15.38 9.71 12 170099 632 79573645
Hypoplastic left heart syndrome 15.35 9.71 4 170107 11 79574266
Spinal shock 15.32 9.71 5 170106 36 79574241
Pneumothorax 15.21 9.71 23 170088 28300 79545977
Large intestine perforation 15.21 9.71 6 170105 14561 79559716
Creatinine renal clearance decreased 15.19 9.71 11 170100 18991 79555286
Fluid retention 15.17 9.71 87 170024 69722 79504555
Cellulitis 15.13 9.71 154 169957 108906 79465371
Energy increased 15.12 9.71 26 170085 3256 79571021
Parkinsonian gait 15.11 9.71 14 170097 934 79573343
Tourette's disorder 15.11 9.71 6 170105 80 79574197
Nystagmus 15.07 9.71 51 170060 9853 79564424
Lip dry 15.06 9.71 7 170104 15411 79558866
Slow response to stimuli 15.01 9.71 19 170092 1806 79572471
Skin ulcer 14.94 9.71 62 170049 54088 79520189
Therapy change 14.89 9.71 42 170069 7357 79566920
Osteoarthritis 14.87 9.71 117 169994 87192 79487085
Facet joint syndrome 14.86 9.71 3 170108 11299 79562978
Panniculitis 14.85 9.71 4 170107 12367 79561910
Gastric bypass 14.81 9.71 16 170095 1285 79572992
Acute myeloid leukaemia 14.80 9.71 27 170084 30858 79543419
Menstruation irregular 14.78 9.71 33 170078 5003 79569274
Decreased appetite 14.74 9.71 589 169522 341829 79232448
Blood magnesium decreased 14.70 9.71 72 170039 16440 79557837
Pericardial effusion 14.67 9.71 50 170061 46187 79528090
Device expulsion 14.65 9.71 100 170011 25761 79548516
Maternal exposure during pregnancy 14.64 9.71 204 169907 136334 79437943
Joint hyperextension 14.61 9.71 9 170102 322 79573955
Autism spectrum disorder 14.59 9.71 15 170096 1137 79573140
Vitamin B1 decreased 14.56 9.71 11 170100 552 79573725
Coma uraemic 14.54 9.71 5 170106 43 79574234
Pregnancy on oral contraceptive 14.49 9.71 13 170098 832 79573445
Diffuse large B-cell lymphoma 14.44 9.71 4 170107 12145 79562132
Feeling jittery 14.44 9.71 60 170051 12781 79561496
Enuresis 14.42 9.71 25 170086 3151 79571126
Dyslipidaemia 14.40 9.71 56 170055 11577 79562700
Atrial septal defect 14.24 9.71 19 170092 1903 79572374
Pain in extremity 14.23 9.71 634 169477 363904 79210373
Atrioventricular block second degree 14.22 9.71 41 170070 7271 79567006
Appendicitis 14.22 9.71 14 170097 20780 79553497
Mast cell activation syndrome 14.21 9.71 12 170099 708 79573569
Antisocial behaviour 14.19 9.71 12 170099 709 79573568
Post 5-alpha-reductase inhibitor syndrome 14.18 9.71 6 170105 95 79574182
Disturbance in sexual arousal 14.17 9.71 8 170103 243 79574034
Micturition urgency 14.16 9.71 59 170052 12582 79561695
Swelling face 14.15 9.71 222 169889 70990 79503287
Death of relative 14.08 9.71 8 170103 246 79574031
Klebsiella infection 14.07 9.71 8 170103 15712 79558565
Drug-induced liver injury 14.04 9.71 83 170028 66034 79508243
Anorexia nervosa 14.02 9.71 8 170103 248 79574029
Hypnopompic hallucination 14.01 9.71 6 170105 98 79574179
Cold agglutinins positive 13.97 9.71 5 170106 49 79574228
Dizziness 13.96 9.71 1304 168807 525137 79049140
Gestational diabetes 13.94 9.71 37 170074 6256 79568021
Locked-in syndrome 13.93 9.71 12 170099 727 79573550
Menopausal symptoms 13.92 9.71 19 170092 1944 79572333
Metastases to lung 13.90 9.71 11 170100 18152 79556125
Prolonged rupture of membranes 13.88 9.71 5 170106 50 79574227
Fall 13.86 9.71 1214 168897 486415 79087862
Impulse-control disorder 13.86 9.71 18 170093 1756 79572521
Haemolysis 13.84 9.71 5 170106 12807 79561470
Hypoprolactinaemia 13.83 9.71 4 170107 18 79574259
Legal problem 13.78 9.71 7 170104 171 79574106
Venoocclusive liver disease 13.76 9.71 4 170107 11767 79562510
Heart disease congenital 13.75 9.71 11 170100 601 79573676
Renal disorder 13.72 9.71 45 170066 42060 79532217
Premature baby 13.69 9.71 27 170084 3753 79570524
Bradykinesia 13.67 9.71 43 170068 8000 79566277
Ventricular hypertrophy 13.59 9.71 39 170072 6899 79567378
Purple glove syndrome 13.57 9.71 8 170103 264 79574013
Alcohol withdrawal syndrome 13.57 9.71 19 170092 1992 79572285
Blood triglycerides increased 13.54 9.71 84 170027 20956 79553321
Asthenia 13.49 9.71 925 169186 510764 79063513
Hypoxic-ischaemic encephalopathy 13.47 9.71 42 170069 7778 79566499
Cardiac output increased 13.46 9.71 8 170103 268 79574009
Full blood count abnormal 13.37 9.71 43 170068 40431 79533846
Respiratory failure 13.37 9.71 289 169822 180622 79393655
Second primary malignancy 13.29 9.71 7 170104 14343 79559934
Interstitial lung disease 13.25 9.71 165 169946 112435 79461842
Stereotypy 13.25 9.71 13 170098 932 79573345
Multiple system atrophy 13.22 9.71 9 170102 383 79573894
Blood test abnormal 13.21 9.71 11 170100 17699 79556578
Renal failure 13.18 9.71 327 169784 200641 79373636
Blood creatine phosphokinase MB 13.17 9.71 4 170107 22 79574255
Heavy menstrual bleeding 13.13 9.71 62 170049 13949 79560328
Blood phosphorus increased 13.09 9.71 3 170108 10344 79563933
Dissociative identity disorder 13.07 9.71 5 170106 60 79574217
Intrusive thoughts 13.03 9.71 10 170101 514 79573763
Maternal drugs affecting foetus 13.03 9.71 17 170094 1666 79572611
Jaw clicking 13.02 9.71 4 170107 23 79574254
Umbilical cord around neck 13.02 9.71 4 170107 23 79574254
Hyperdynamic left ventricle 13.00 9.71 9 170102 394 79573883
Productive cough 12.98 9.71 123 169988 88208 79486069
Body temperature decreased 12.97 9.71 31 170080 32114 79542163
Plasma cell myeloma 12.89 9.71 64 170047 53195 79521082
Dissociative disorder 12.85 9.71 12 170099 809 79573468
Status migrainosus 12.85 9.71 5 170106 63 79574214
End stage renal disease 12.81 9.71 5 170106 12215 79562062
Antidepressant drug level above therapeutic 12.79 9.71 11 170100 665 79573612
Tongue biting 12.79 9.71 19 170092 2102 79572175
Drug withdrawal syndrome neonatal 12.77 9.71 8 170103 295 79573982
Rash maculo-papular 12.67 9.71 69 170042 56009 79518268
Personality change 12.62 9.71 49 170062 10121 79564156
Enterococcal infection 12.60 9.71 9 170102 15651 79558626
Premature labour 12.59 9.71 43 170068 8347 79565930
Mutism 12.55 9.71 20 170091 2352 79571925
Electrolyte depletion 12.55 9.71 9 170102 417 79573860
Compulsive hoarding 12.50 9.71 5 170106 68 79574209
Blood potassium decreased 12.49 9.71 153 169958 46359 79527918
Haemorrhage intracranial 12.46 9.71 23 170088 26170 79548107
Antisocial personality disorder 12.44 9.71 5 170106 69 79574208
Ventricular fibrillation 12.33 9.71 113 169998 31813 79542464
Disability 12.32 9.71 11 170100 17109 79557168
Psychiatric symptom 12.31 9.71 38 170073 6997 79567280
Injury 12.29 9.71 233 169878 77263 79497014
Abortion spontaneous 12.20 9.71 106 170005 29401 79544876
Lumbar radiculopathy 12.19 9.71 18 170093 1981 79572296
Cholangitis 12.18 9.71 6 170105 12770 79561507
Tremor neonatal 12.17 9.71 3 170108 6 79574271
Right aortic arch 12.17 9.71 3 170108 6 79574271
Acquired cardiac septal defect 12.17 9.71 3 170108 6 79574271
Apgar score low 12.17 9.71 3 170108 6 79574271
Intervertebral disc displacement 12.12 9.71 9 170102 440 79573837
Procedural hypertension 12.08 9.71 8 170103 325 79573952
Food allergy 12.08 9.71 4 170107 10820 79563457
Duodenal ulcer repair 12.06 9.71 5 170106 75 79574202
Developmental delay 12.06 9.71 14 170097 1217 79573060
Coagulation factor VII level decreased 12.04 9.71 7 170104 225 79574052
Nodule 12.03 9.71 19 170092 22975 79551302
Grandiosity 12.03 9.71 10 170101 577 79573700
Metastases to bone 12.03 9.71 21 170090 24406 79549871
Spontaneous haematoma 12.01 9.71 15 170096 1407 79572870
Brugada syndrome 11.99 9.71 14 170097 1224 79573053
Chemical burn 11.94 9.71 10 170101 583 79573694
Acute psychosis 11.83 9.71 27 170084 4153 79570124
Plasma cell mastitis 11.78 9.71 4 170107 33 79574244
Agonal rhythm 11.77 9.71 5 170106 80 79574197
Enthesopathy 11.76 9.71 5 170106 11603 79562674
Vascular stenosis 11.75 9.71 10 170101 596 79573681
Hypothermia 11.75 9.71 86 170025 22660 79551617
Placenta praevia 11.75 9.71 11 170100 744 79573533
Asthma 11.74 9.71 210 169901 134885 79439392
Toxic epidermal necrolysis 11.71 9.71 52 170059 44529 79529748
Muscle necrosis 11.71 9.71 15 170096 1443 79572834
Long QT syndrome congenital 11.65 9.71 6 170105 151 79574126
Gastrointestinal hypermotility 11.64 9.71 8 170103 346 79573931
Cushingoid 11.63 9.71 3 170108 9549 79564728
Blood parathyroid hormone decreased 11.57 9.71 4 170107 10532 79563745
Gout 11.54 9.71 22 170089 24727 79549550
Gastric disorder 11.53 9.71 41 170070 37392 79536885
Low birth weight baby 11.51 9.71 10 170101 613 79573664
Appendicitis perforated 11.50 9.71 23 170088 3230 79571047
Lung disorder 11.49 9.71 113 169998 80444 79493833
Theft 11.48 9.71 7 170104 246 79574031
Rabbit syndrome 11.46 9.71 8 170103 355 79573922
Skin necrosis 11.44 9.71 13 170098 18074 79556203
Affect lability 11.43 9.71 51 170060 11208 79563069
Cerebrovascular stenosis 11.40 9.71 6 170105 158 79574119
Bladder dilatation 11.39 9.71 18 170093 2101 79572176
Squamous cell carcinoma of skin 11.38 9.71 8 170103 14025 79560252
Pre-eclampsia 11.38 9.71 37 170074 7004 79567273
Neonatal respiratory distress syndrome 11.38 9.71 7 170104 250 79574027
Food interaction 11.36 9.71 16 170095 1686 79572591
Joint effusion 11.34 9.71 13 170098 18001 79556276
Psychotic behaviour 11.33 9.71 13 170098 1116 79573161
Medical diet 11.32 9.71 3 170108 9 79574268
Prostatic specific antigen increased 11.31 9.71 4 170107 10382 79563895
Haemorrhage 11.30 9.71 132 169979 90986 79483291
Red blood cell count decreased 11.28 9.71 74 170037 57439 79516838
Renal artery thrombosis 11.28 9.71 9 170102 490 79573787
Oesophageal achalasia 11.27 9.71 11 170100 783 79573494
Platelet count increased 11.27 9.71 19 170092 22387 79551890
Pulmonary fibrosis 11.26 9.71 52 170059 44060 79530217
Skin disorder 11.26 9.71 36 170075 33907 79540370
Alpha 1 globulin increased 11.23 9.71 5 170106 90 79574187
Schizoaffective disorder 11.19 9.71 18 170093 2134 79572143
Cataract 11.16 9.71 82 170029 62038 79512239
Peripheral sensory neuropathy 11.15 9.71 7 170104 13026 79561251
Pulmonary valve stenosis 11.10 9.71 4 170107 40 79574237
Hyperinsulinism 11.08 9.71 3 170108 10 79574267
Cardiomegaly 11.07 9.71 95 170016 26257 79548020
Back pain 11.06 9.71 533 169578 303647 79270630
Chronic fatigue syndrome 11.04 9.71 14 170097 1333 79572944
COVID-19 11.04 9.71 254 169857 157420 79416857
Uterine hypertonus 11.04 9.71 7 170104 264 79574013
Hypogammaglobulinaemia 11.02 9.71 7 170104 12944 79561333
Persecutory delusion 11.01 9.71 29 170082 4880 79569397
Fistula 11.00 9.71 7 170104 12933 79561344
Pulmonary toxicity 10.96 9.71 7 170104 12907 79561370
Loss of bladder sensation 10.94 9.71 5 170106 96 79574181
Blood pressure diastolic abnormal 10.90 9.71 15 170096 19187 79555090
Heart rate abnormal 10.87 9.71 33 170078 6024 79568253
Oral candidiasis 10.85 9.71 30 170081 29598 79544679
Hypertransaminasaemia 10.77 9.71 6 170105 11918 79562359
Sleep attacks 10.72 9.71 6 170105 179 79574098
Full blood count decreased 10.71 9.71 26 170085 26793 79547484
Hypertriglyceridaemia 10.68 9.71 7 170104 12733 79561544
Melanocytic hyperplasia 10.65 9.71 3 170108 12 79574265
Jaw disorder 10.65 9.71 29 170082 4977 79569300
Chronic kidney disease 10.65 9.71 90 170021 66064 79508213
Compulsions 10.62 9.71 8 170103 400 79573877
Eye colour change 10.57 9.71 8 170103 403 79573874
Head deformity 10.53 9.71 4 170107 47 79574230
Gastric hypomotility 10.52 9.71 6 170105 186 79574091
Hypervolaemia 10.50 9.71 51 170060 42639 79531638
Hypnagogic hallucination 10.46 9.71 6 170105 188 79574089
Skin cancer 10.43 9.71 10 170101 15030 79559247
Delusion of grandeur 10.37 9.71 14 170097 1418 79572859
Gaze palsy 10.33 9.71 21 170090 2984 79571293
Imprisonment 10.33 9.71 9 170102 554 79573723
Device related infection 10.27 9.71 38 170073 34256 79540021
Biliary dyskinesia 10.23 9.71 19 170092 2526 79571751
Dehydration 10.22 9.71 429 169682 247758 79326519
Food craving 10.22 9.71 15 170096 1642 79572635
Regurgitation 10.21 9.71 20 170091 2767 79571510
Clostridium difficile colitis 10.18 9.71 35 170076 32248 79542029
Withdrawal catatonia 10.15 9.71 6 170105 199 79574078
Anal incontinence 10.14 9.71 70 170041 18098 79556179
Metastases to liver 10.13 9.71 29 170082 28285 79545992
Otosalpingitis 10.11 9.71 3 170108 15 79574262
Testicular microlithiasis 10.11 9.71 3 170108 15 79574262
Pregnancy with contraceptive patch 10.11 9.71 3 170108 15 79574262
Sex hormone binding globulin decreased 10.11 9.71 3 170108 15 79574262
Alpha 2 globulin decreased 10.11 9.71 3 170108 15 79574262
Adverse event 10.11 9.71 81 170030 60133 79514144
Exposure during pregnancy 10.10 9.71 285 169826 100847 79473430
Hypoglycaemia neonatal 10.10 9.71 4 170107 53 79574224
Foetal alcohol syndrome 10.10 9.71 4 170107 53 79574224
Pneumonia bacterial 10.09 9.71 16 170095 19315 79554962
Inadequate analgesia 10.03 9.71 27 170084 4602 79569675
Carcinoid syndrome 10.02 9.71 6 170105 204 79574073
Pulmonary alveolar haemorrhage 10.01 9.71 6 170105 11451 79562826
Trismus 10.01 9.71 30 170081 5437 79568840
Colorectal cancer 10.00 9.71 3 170108 8644 79565633
Muscle neoplasm 9.96 9.71 4 170107 55 79574222
Androgen insensitivity syndrome 9.95 9.71 3 170108 16 79574261
Secondary tic 9.95 9.71 3 170108 16 79574261
Free androgen index decreased 9.95 9.71 3 170108 16 79574261
Fear of crowded places 9.95 9.71 3 170108 16 79574261
Hepatic cancer 9.95 9.71 5 170106 10524 79563753
Polydipsia psychogenic 9.91 9.71 6 170105 208 79574069
Tinnitus 9.89 9.71 141 169970 44192 79530085
Ventricular extrasystoles 9.89 9.71 74 170037 19630 79554647
Respiratory tract infection 9.88 9.71 62 170049 48627 79525650
Anticholinergic syndrome 9.86 9.71 23 170088 3588 79570689
Tooth hypoplasia 9.84 9.71 6 170105 211 79574066
Alcohol problem 9.83 9.71 4 170107 57 79574220
Febrile bone marrow aplasia 9.82 9.71 8 170103 13012 79561265
Blood glucose fluctuation 9.81 9.71 34 170077 6648 79567629
Exposure via inhalation 9.81 9.71 5 170106 123 79574154
Cyclothymic disorder 9.81 9.71 6 170105 212 79574065
Wound infection 9.78 9.71 23 170088 23968 79550309
Vasoplegia syndrome 9.78 9.71 23 170088 3607 79570670
Haemodynamic instability 9.72 9.71 67 170044 17315 79556962
Hallucination, tactile 9.72 9.71 9 170102 600 79573677

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Feeling jittery 45.63 22.91 18 774 44 88956
Exposure during pregnancy 32.11 22.91 48 744 1286 87714
Hypertonia neonatal 27.90 22.91 23 769 304 88696
Tremor neonatal 22.95 22.91 13 779 87 88913

Pharmacologic Action:

SourceCodeDescription
ATC N06AB03 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
ATC N06CA03 NERVOUS SYSTEM
PSYCHOANALEPTICS
PSYCHOLEPTICS AND PSYCHOANALEPTICS IN COMBINATION
Antidepressants in combination with psycholeptics
FDA MoA N0000000109 Serotonin Uptake Inhibitors
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:50949 SSRI
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:88188 allergenic drug
MeSH PA D000928 Antidepressive Agents
MeSH PA D018687 Antidepressive Agents, Second-Generation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D065690 Cytochrome P-450 CYP2D6 Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D017367 Selective Serotonin Reuptake Inhibitors
MeSH PA D018490 Serotonin Agents
FDA EPC N0000175696 Serotonin Reuptake Inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Premenstrual dysphoric disorder indication 596004
Depressive disorder indication 35489007
Bulimia nervosa indication 78004001
Bipolar affective disorder, current episode depression indication 191627008 DOID:3312
Obsessive-compulsive disorder indication 191736004 DOID:10933
Major depressive disorder indication 370143000
Panic disorder indication 371631005 DOID:594
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Postpartum depression off-label use 58703003 DOID:9478
Cataplexy and narcolepsy off-label use 193042000
Menopausal flushing off-label use 198436008
Fibromyalgia off-label use 203082005 DOID:631
Seasonal affective disorder off-label use 247803002
Suicidal thoughts contraindication 6471006
Weight gain finding contraindication 8943002
Sinus tachycardia contraindication 11092001
Hypercholesterolemia contraindication 13644009
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Cirrhosis of liver contraindication 19943007 DOID:5082
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Dehydration contraindication 34095006
Upper gastrointestinal hemorrhage contraindication 37372002
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Paralytic ileus contraindication 55525008 DOID:8442
Hyperlipidemia contraindication 55822004 DOID:1168
Anorexia nervosa contraindication 56882008 DOID:8689
Abnormal sexual function contraindication 56925008
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Heart failure contraindication 84114007 DOID:6000
Epilepsy contraindication 84757009 DOID:1826
Leukopenia contraindication 84828003 DOID:615
Hyponatremia contraindication 89627008
Tardive dyskinesia contraindication 102449007
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Cerebrovascular accident contraindication 230690007
Mania contraindication 231494001
Hypomania contraindication 231496004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Transient ischemic attack contraindication 266257000 DOID:224
Esophageal dysmotility contraindication 266434009 DOID:9192
Benign prostatic hyperplasia contraindication 266569009
Hypertriglyceridemia contraindication 302870006
Neutropenic disorder contraindication 303011007 DOID:1227
Serotonin syndrome contraindication 371089000
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Dogs Separation anxiety Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Reconcile Pegasus Laboratories Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.32 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 9.09 WOMBAT-PK CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 8.20 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 6.07 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.16 WOMBAT-PK
Sodium-dependent noradrenaline transporter Transporter Kd 6.62 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR Ki 6.61 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR ANTAGONIST Ki 5.30 IUPHAR
5-hydroxytryptamine receptor 2C GPCR Ki 6.40 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 6.11 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 5.70 PDSP
Alpha-2B adrenergic receptor GPCR Ki 6.16 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 5.70 WOMBAT-PK
Histamine H1 receptor GPCR Ki 5.96 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 6.05 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 5.57 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 6 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR Ki 5.54 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 5.57 PDSP
Sodium-dependent dopamine transporter Transporter Kd 5.44 WOMBAT-PK
Cytochrome P450 2D6 Enzyme IC50 6.16 DRUG MATRIX
Acetylcholinesterase Enzyme IC50 6.89 CHEMBL
Potassium channel subfamily K member 2 Ion channel IC50 4.85 CHEMBL
Histamine H3 receptor GPCR Ki 5.14 CHEMBL
Equilibrative nucleoside transporter 4 Transporter INHIBITOR Ki 4.64 IUPHAR
Beta-1 adrenergic receptor GPCR Ki 5.36 WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 8.70 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 6.11 CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 6.50 IUPHAR
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.62 CHEMBL
Transporter Transporter Ki 6.84 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 7.97 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 7.07 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 6.96 CHEMBL
5-hydroxytryptamine receptor 6 GPCR ANTAGONIST Ki 5.80 IUPHAR
Transporter Transporter Ki 6.80 CHEMBL
Serotonin 1 (5-HT1) receptor GPCR IC50 7.82 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 5.72 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 6.22 CHEMBL
Potassium voltage-gated channel subfamily C member 1 Ion channel IC50 4.88 CHEMBL
G protein-activated inward rectifier potassium channel 2 Ion channel GATING INHIBITOR IC50 4.80 IUPHAR
Sigma intracellular receptor 2 Unclassified Ki 4.79 CHEMBL

External reference:

IDSource
D00326 KEGG_DRUG
56296-78-7 SECONDARY_CAS_RN
4019389 VANDF
4019761 VANDF
C0016365 UMLSCUI
CHEBI:5118 CHEBI
RFX PDB_CHEM_ID
CHEMBL1201082 ChEMBL_ID
CHEMBL153036 ChEMBL_ID
CHEMBL41 ChEMBL_ID
DB00472 DRUGBANK_ID
D005473 MESH_DESCRIPTOR_UI
3386 PUBCHEM_CID
203 IUPHAR_LIGAND_ID
3883 INN_ID
01K63SUP8D UNII
227224 RXNORM
17711 MMSL
28237 MMSL
37675 MMSL
4091 MMSL
41730 MMSL
4746 MMSL
d00236 MMSL
001514 NDDF
004613 NDDF
372767007 SNOMEDCT_US
53640004 SNOMEDCT_US
75115009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3230 CAPSULE 25 mg ORAL NDA 34 sections
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3230 CAPSULE 25 mg ORAL NDA 34 sections
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3231 CAPSULE 25 mg ORAL NDA 34 sections
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3231 CAPSULE 25 mg ORAL NDA 34 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-0807 TABLET, FILM COATED 20 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-0807 TABLET, FILM COATED 20 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-0807 TABLET, FILM COATED 20 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5262 TABLET, FILM COATED 60 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5262 TABLET, FILM COATED 60 mg ORAL ANDA 32 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5503 CAPSULE 25 mg ORAL ANDA 32 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5504 CAPSULE 25 mg ORAL ANDA 32 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5505 CAPSULE 50 mg ORAL ANDA 32 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5506 CAPSULE 25 mg ORAL ANDA 32 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5507 CAPSULE 50 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7188 TABLET, FILM COATED 10 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7188 TABLET, FILM COATED 10 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7188 TABLET, FILM COATED 10 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7198 CAPSULE 40 mg ORAL ANDA 31 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7198 CAPSULE 40 mg ORAL ANDA 31 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7198 CAPSULE 40 mg ORAL ANDA 31 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0121-0721 SOLUTION 20 mg ORAL ANDA 33 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0121-0721 SOLUTION 20 mg ORAL ANDA 33 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0121-4721 SOLUTION 20 mg ORAL ANDA 33 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0121-4721 SOLUTION 20 mg ORAL ANDA 33 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-1384 CAPSULE 10 mg ORAL ANDA 33 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-7625 CAPSULE 20 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-7625 CAPSULE 20 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-7638 CAPSULE 10 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8093 CAPSULE 10 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8093 CAPSULE 10 mg ORAL ANDA 32 sections