fluoxetine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives 1209 54910-89-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prozac
  • fluoxetine
  • fluoxetine hydrochloride
  • fluoxetin
  • fluoxetine HCl
The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
  • Molecular weight: 309.33
  • Formula: C17H18F3NO
  • CLOGP: 4.57
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 21.26
  • ALOGS: -5.26
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 15.20 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.25 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 4.30 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1987 FDA ELI LILLY AND CO

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1384.32 9.81 1729 133111 130160 50340124
Intentional overdose 822.75 9.81 921 133919 61583 50408701
Toxicity to various agents 710.32 9.81 1673 133167 210826 50259458
Suicidal ideation 697.99 9.81 798 134042 54587 50415697
Serotonin syndrome 506.45 9.81 463 134377 24250 50446034
Drug abuse 481.28 9.81 690 134150 59156 50411128
Suicide attempt 469.15 9.81 632 134208 51100 50419184
Intentional self-injury 446.48 9.81 419 134421 22693 50447591
Drug interaction 422.27 9.81 1329 133511 198292 50271992
Electrocardiogram QT prolonged 319.69 9.81 529 134311 51357 50418927
Anxiety 294.92 9.81 1091 133749 176515 50293769
Tremor 290.07 9.81 815 134025 114088 50356196
Systemic lupus erythematosus 271.93 9.81 29 134811 140593 50329691
Agitation 264.98 9.81 495 134345 52889 50417395
Drug intolerance 263.87 9.81 127 134713 218977 50251307
Synovitis 251.55 9.81 21 134819 123844 50346440
Hand deformity 238.47 9.81 6 134834 100193 50370091
Cardio-respiratory arrest 236.05 9.81 474 134366 53418 50416866
Contraindicated product administered 231.67 9.81 56 134784 148902 50321382
Drug withdrawal syndrome 228.13 9.81 307 134533 24774 50445510
Depression 224.36 9.81 954 133886 164469 50305815
Overdose 219.68 9.81 674 134166 99053 50371231
Joint swelling 212.80 9.81 204 134636 245082 50225202
Withdrawal syndrome 212.20 9.81 248 134592 17342 50452942
Treatment failure 209.66 9.81 54 134786 137583 50332701
Glossodynia 190.70 9.81 38 134802 115531 50354753
Poisoning 189.28 9.81 198 134642 12231 50458053
Respiratory arrest 188.86 9.81 309 134531 29700 50440584
Infusion related reaction 186.83 9.81 110 134730 169447 50300837
Cardiac arrest 182.92 9.81 564 134276 83087 50387197
Irritability 176.60 9.81 291 134549 28135 50442149
Rash 173.79 9.81 592 134248 436879 50033405
Alopecia 173.37 9.81 240 134600 244807 50225477
Wound 172.03 9.81 36 134804 105758 50364526
Swelling 157.38 9.81 182 134658 200690 50269594
Reversible cerebral vasoconstriction syndrome 153.88 9.81 86 134754 2033 50468251
Pericarditis 152.64 9.81 16 134824 78673 50391611
Somnolence 152.62 9.81 815 134025 154170 50316114
Peripheral swelling 150.38 9.81 197 134643 205739 50264545
Drug ineffective 148.98 9.81 1433 133407 817900 49652384
Arthropathy 143.15 9.81 126 134714 157780 50312504
Abdominal discomfort 142.69 9.81 249 134591 231392 50238892
Akathisia 141.53 9.81 140 134700 8089 50462195
Nightmare 138.85 9.81 192 134648 15894 50454390
Aggression 137.72 9.81 221 134619 20895 50449389
Torsade de pointes 128.21 9.81 158 134682 11677 50458607
Disturbance in attention 124.39 9.81 264 134576 30922 50439362
Hepatic enzyme increased 120.47 9.81 113 134727 137267 50333017
Depressed mood 118.73 9.81 273 134567 33750 50436534
Arthralgia 117.66 9.81 687 134153 438015 50032269
Panic attack 116.10 9.81 195 134645 19147 50451137
Mania 115.47 9.81 144 134696 10772 50459512
Rheumatoid factor positive 114.90 9.81 4 134836 49855 50420429
Infection 114.77 9.81 177 134663 172777 50297507
Febrile neutropenia 113.83 9.81 59 134781 97608 50372676
Suicidal behaviour 113.02 9.81 73 134767 2261 50468023
Sopor 110.89 9.81 194 134646 19685 50450599
Product complaint 105.23 9.81 141 134699 11325 50458959
Therapeutic product effect decreased 104.63 9.81 125 134715 135925 50334359
Crying 104.61 9.81 192 134648 20224 50450060
Mydriasis 102.65 9.81 134 134706 10493 50459791
White blood cell count abnormal 100.01 9.81 96 134744 5344 50464940
Rheumatoid arthritis 99.96 9.81 247 134593 202303 50267981
Product use issue 99.13 9.81 153 134687 149322 50320962
Discomfort 98.76 9.81 86 134754 108294 50361990
Foetal exposure during pregnancy 98.20 9.81 222 134618 27137 50443147
Product substitution issue 97.02 9.81 151 134689 13906 50456378
Seizure 94.45 9.81 587 134253 117287 50352997
Helicobacter infection 94.12 9.81 11 134829 49691 50420593
Duodenal ulcer perforation 91.82 9.81 8 134832 45603 50424681
Neutropenia 90.17 9.81 160 134680 147805 50322479
Hypersensitivity 89.42 9.81 285 134555 214876 50255408
Muscle rigidity 87.36 9.81 119 134721 9710 50460574
Respiratory depression 87.09 9.81 132 134708 11878 50458406
Nasopharyngitis 85.56 9.81 248 134592 192679 50277605
Self-injurious ideation 84.72 9.81 60 134780 2169 50468115
Pneumonia 83.96 9.81 627 134213 377774 50092510
Lower respiratory tract infection 83.80 9.81 78 134762 95123 50375161
Coma scale abnormal 83.59 9.81 82 134758 4689 50465595
Coma 82.39 9.81 335 134505 56544 50413740
Suspected suicide 80.95 9.81 85 134755 5272 50465012
Dystonia 79.38 9.81 126 134714 11800 50458484
Folliculitis 78.63 9.81 7 134833 39218 50431066
Stomatitis 78.02 9.81 93 134747 101251 50369033
Blister 77.55 9.81 68 134772 85350 50384934
Insomnia 76.15 9.81 756 134084 174109 50296175
Galactorrhoea 74.76 9.81 69 134771 3654 50466630
Anger 73.05 9.81 118 134722 11215 50459069
Depressed level of consciousness 72.89 9.81 303 134537 51650 50418634
Mood swings 71.81 9.81 142 134698 15812 50454472
Bezoar 69.84 9.81 44 134796 1304 50468980
Muscle twitching 69.04 9.81 137 134703 15294 50454990
Abnormal behaviour 68.87 9.81 158 134682 19500 50450784
Muscle injury 68.34 9.81 9 134831 37102 50433182
Tearfulness 67.66 9.81 65 134775 3622 50466662
Sleep disorder due to general medical condition, insomnia type 67.65 9.81 4 134836 31443 50438841
Poisoning deliberate 67.62 9.81 94 134746 7818 50462466
Off label use 67.40 9.81 876 133964 473550 49996734
Hypertonia neonatal 66.89 9.81 25 134815 219 50470065
Impaired healing 66.49 9.81 53 134787 69733 50400551
Drug dependence 66.14 9.81 156 134684 19603 50450681
Exposure during pregnancy 65.79 9.81 549 134291 120466 50349818
Obsessive-compulsive disorder 65.33 9.81 61 134779 3279 50467005
Hyperprolactinaemia 64.94 9.81 61 134779 3304 50466980
Restlessness 64.81 9.81 180 134660 24993 50445291
Pyrexia 64.02 9.81 676 134164 379527 50090757
Electrocardiogram QRS complex prolonged 63.86 9.81 75 134765 5269 50465015
Confusional state 63.50 9.81 766 134074 185162 50285122
Hyperhidrosis 63.45 9.81 432 134408 88994 50381290
Extrapyramidal disorder 61.95 9.81 112 134728 11658 50458626
Hallucination, auditory 61.53 9.81 106 134734 10622 50459662
Parkinsonism 61 9.81 95 134745 8752 50461532
Myoclonus 60.61 9.81 125 134715 14345 50455939
Miosis 60.06 9.81 79 134761 6231 50464053
Generalised tonic-clonic seizure 59.88 9.81 180 134660 26130 50444154
Restless legs syndrome 59.29 9.81 131 134709 15766 50454518
Memory impairment 59.08 9.81 388 134452 78972 50391312
General physical health deterioration 58.20 9.81 190 134650 142244 50328040
Pancytopenia 56.65 9.81 85 134755 83945 50386339
Sedation 56.58 9.81 195 134645 30415 50439869
Malignant neoplasm progression 56.27 9.81 59 134781 68065 50402219
Gastrointestinal disorder 54.97 9.81 105 134735 94351 50375933
Disease progression 54.55 9.81 108 134732 95758 50374526
Intentional product misuse 54.53 9.81 258 134582 46476 50423808
Therapeutic product effect incomplete 53.90 9.81 101 134739 91414 50378870
Anaemia 53.68 9.81 423 134417 252033 50218251
Therapeutic response unexpected 53.64 9.81 126 134714 15789 50454495
Platelet count decreased 53.51 9.81 118 134722 100608 50369676
Drug withdrawal syndrome neonatal 53.10 9.81 42 134798 1799 50468485
Cerebral vasoconstriction 52.96 9.81 33 134807 959 50469325
Tardive dyskinesia 52.77 9.81 80 134760 7199 50463085
Myocardial depression 52.14 9.81 25 134815 425 50469859
Mood altered 51.93 9.81 109 134731 12664 50457620
Emotional distress 51.59 9.81 181 134659 28482 50441802
Paranoia 51.35 9.81 96 134744 10252 50460032
Cholecystitis chronic 50.88 9.81 92 134748 9577 50460707
Renal impairment 50.55 9.81 77 134763 75584 50394700
Abnormal dreams 50.34 9.81 90 134750 9287 50460997
Thrombocytopenia 49.64 9.81 174 134666 127499 50342785
Mucosal inflammation 48.64 9.81 23 134817 40119 50430165
Hyperreflexia 48.60 9.81 64 134776 5054 50465230
Persistent genital arousal disorder 48.55 9.81 20 134820 232 50470052
Libido increased 48.50 9.81 34 134806 1209 50469075
Decorticate posture 48.24 9.81 21 134819 282 50470002
Dyspnoea 47.70 9.81 1104 133736 546504 49923780
Clonus 47.27 9.81 57 134783 4118 50466166
Tic 46.81 9.81 33 134807 1184 50469100
Impulsive behaviour 45.83 9.81 35 134805 1423 50468861
Hostility 45.79 9.81 38 134802 1744 50468540
Atrial fibrillation 45.63 9.81 130 134710 101615 50368669
Pulseless electrical activity 45.15 9.81 72 134768 6769 50463515
Dyskinesia 45.12 9.81 170 134670 27691 50442593
Atrial septal defect 44.99 9.81 69 134771 6272 50464012
Maternal exposure during breast feeding 44.54 9.81 49 134791 3205 50467079
Accidental death 44.42 9.81 37 134803 1707 50468577
Cough 44.26 9.81 420 134420 240844 50229440
Amnesia 44.10 9.81 226 134614 42034 50428250
Alcohol interaction 43.56 9.81 40 134800 2104 50468180
Diarrhoea 43.32 9.81 1216 133624 587260 49883024
C-reactive protein increased 43.12 9.81 69 134771 66405 50403879
Pain 42.92 9.81 1195 133645 577708 49892576
Intentional product use issue 41.76 9.81 89 134751 76829 50393455
Long QT syndrome 41.17 9.81 45 134795 2922 50467362
Sinusitis 40.94 9.81 276 134564 170282 50300002
Ill-defined disorder 40.11 9.81 52 134788 54602 50415682
Feeling abnormal 39.78 9.81 510 134330 124982 50345302
Bradyphrenia 39.57 9.81 64 134776 6088 50464196
Blood hyposmosis 39.42 9.81 10 134830 17 50470267
Hip arthroplasty 39.13 9.81 16 134824 30413 50439871
Stress cardiomyopathy 38.93 9.81 73 134767 7814 50462470
Blood pressure fluctuation 38.34 9.81 24 134816 35799 50434485
Ventricular fibrillation 38.24 9.81 86 134754 10473 50459811
Mobility decreased 38.21 9.81 99 134741 79849 50390435
Agitation neonatal 38.13 9.81 21 134819 482 50469802
Euphoric mood 37.41 9.81 50 134790 4005 50466279
Multiple sclerosis 37.39 9.81 130 134710 20363 50449921
Depressive symptom 36.74 9.81 44 134796 3156 50467128
Pre-eclampsia 36.69 9.81 72 134768 7972 50462312
Dependence 36.20 9.81 34 134806 1841 50468443
Anorgasmia 36.20 9.81 21 134819 534 50469750
Atrioventricular block first degree 35.20 9.81 61 134779 6140 50464144
Bone marrow failure 34.76 9.81 15 134825 27609 50442675
Sinus bradycardia 34.66 9.81 95 134745 13088 50457196
Knee arthroplasty 34.42 9.81 27 134813 35819 50434465
Maternal drugs affecting foetus 34.28 9.81 54 134786 5023 50465261
Hyponatraemia 34.05 9.81 399 134441 95740 50374544
Morbid thoughts 34.01 9.81 20 134820 522 50469762
Cogwheel rigidity 33.88 9.81 32 134808 1745 50468539
Apathy 33.75 9.81 67 134773 7481 50462803
Traumatic coma 33.73 9.81 11 134829 61 50470223
Blood creatinine increased 33.64 9.81 98 134742 76062 50394222
Hallucination, visual 33.63 9.81 109 134731 16473 50453811
Oculogyric crisis 33.55 9.81 29 134811 1408 50468876
Speech disorder 32.93 9.81 184 134656 35364 50434920
Cardiac failure 32.75 9.81 99 134741 75941 50394343
Delusion of grandeur 32.42 9.81 13 134827 140 50470144
Neuropathy peripheral 32.38 9.81 140 134700 96617 50373667
Ventricular hypokinesia 32.11 9.81 46 134794 3934 50466350
Major depression 31.86 9.81 62 134778 6822 50463462
Cytomegalovirus infection 31.57 9.81 5 134835 17957 50452327
Hypotonia neonatal 31.48 9.81 24 134816 973 50469311
Mental disorder 31.41 9.81 129 134711 21862 50448422
Blood prolactin increased 31.37 9.81 40 134800 3059 50467225
Physical assault 31.22 9.81 23 134817 885 50469399
Mental impairment 30.88 9.81 86 134754 11958 50458326
Hypertonia 30.71 9.81 45 134795 3928 50466356
Herpes zoster 30.60 9.81 92 134748 70694 50399590
Respiration abnormal 30.03 9.81 51 134789 5051 50465233
Tachycardia 29.75 9.81 401 134439 99362 50370922
Psychotic disorder 29.63 9.81 126 134714 21686 50448598
Acute kidney injury 29.42 9.81 429 134411 227629 50242655
Hallucination 29.35 9.81 219 134621 46438 50423846
Arthritis 29.31 9.81 125 134715 86596 50383688
Loss of libido 29.20 9.81 25 134815 1198 50469086
Abortion missed 29.15 9.81 28 134812 1560 50468724
Breech presentation 29.13 9.81 24 134816 1090 50469194
Inappropriate antidiuretic hormone secretion 29.04 9.81 89 134751 13054 50457230
Fear 28.93 9.81 95 134745 14454 50455830
Soft tissue injury 28.83 9.81 27 134813 1457 50468827
Unresponsive to stimuli 28.73 9.81 159 134681 30450 50439834
Dysarthria 28.51 9.81 184 134656 37219 50433065
Catatonia 28.42 9.81 42 134798 3694 50466590
Accidental overdose 28.23 9.81 115 134725 19418 50450866
Antipsychotic drug level increased 28.17 9.81 38 134802 3071 50467213
Erythema 28.06 9.81 252 134588 146162 50324122
Talipes 27.99 9.81 26 134814 1388 50468896
Pleural effusion 27.78 9.81 117 134723 81337 50388947
Lethargy 27.77 9.81 226 134614 49206 50421078
Stress 27.60 9.81 241 134599 53552 50416732
Burning mouth syndrome 27.58 9.81 16 134824 407 50469877
Sternal fracture 27.15 9.81 30 134810 1972 50468312
Affect lability 26.87 9.81 68 134772 8930 50461354
Neoplasm progression 26.71 9.81 23 134817 29134 50441150
Migraine 26.46 9.81 312 134528 74968 50395316
Pulmonary valve stenosis 26.07 9.81 14 134826 305 50469979
Injury 26.05 9.81 221 134619 48704 50421580
White blood cell count decreased 25.98 9.81 193 134647 116529 50353755
Flat affect 25.84 9.81 24 134816 1281 50469003
Fatigue 25.66 9.81 1585 133255 706016 49764268
Blood lactate dehydrogenase increased 25.62 9.81 10 134830 19552 50450732
Panic reaction 25.55 9.81 39 134801 3530 50466754
Bulimia nervosa 25.49 9.81 15 134825 392 50469892
Urinary incontinence 25.46 9.81 145 134695 28063 50442221
Reduced facial expression 25.36 9.81 26 134814 1568 50468716
Inflammation 25.30 9.81 73 134767 56839 50413445
Haemoglobin decreased 25.24 9.81 217 134623 126999 50343285
Alcoholism 25.01 9.81 26 134814 1594 50468690
Multiple sclerosis relapse 24.98 9.81 198 134642 42766 50427518
Septic shock 24.93 9.81 74 134766 57101 50413183
Attention-seeking behaviour 24.90 9.81 9 134831 71 50470213
Poor quality sleep 24.85 9.81 99 134741 16547 50453737
Protein C increased 24.83 9.81 10 134830 109 50470175
Red blood cell sedimentation rate increased 24.82 9.81 25 134815 29391 50440893
Weight increased 24.81 9.81 709 134131 201182 50269102
Drug abuser 24.77 9.81 34 134806 2794 50467490
Marital problem 24.73 9.81 11 134829 156 50470128
Pulmonary haemosiderosis 24.65 9.81 5 134835 0 50470284
Agoraphobia 24.60 9.81 14 134826 343 50469941
Persistent foetal circulation 24.51 9.81 12 134828 214 50470070
Disinhibition 24.49 9.81 19 134821 791 50469493
Posture abnormal 24.44 9.81 29 134811 2060 50468224
Depression suicidal 24.43 9.81 25 134815 1504 50468780
Drug level increased 24.42 9.81 109 134731 19159 50451125
Trichotillomania 24.28 9.81 10 134830 116 50470168
Heart sounds 24.04 9.81 17 134823 613 50469671
Musculoskeletal pain 23.80 9.81 105 134735 72072 50398212
Irritable bowel syndrome 23.59 9.81 65 134775 51376 50418908
Sinus tachycardia 23.54 9.81 116 134724 21238 50449046
Food interaction 23.42 9.81 17 134823 639 50469645
Dysphoria 23.33 9.81 44 134796 4730 50465554
Thinking abnormal 23.24 9.81 67 134773 9500 50460784
Self esteem decreased 23.22 9.81 16 134824 553 50469731
Heart rate 22.60 9.81 8 134832 59 50470225
Hypothermia 22.60 9.81 77 134763 11939 50458345
Pulmonary valve stenosis congenital 22.41 9.81 10 134830 143 50470141
Narcolepsy 22.33 9.81 21 134819 1139 50469145
Concussion 22.11 9.81 57 134783 7571 50462713
Metabolic acidosis 22.07 9.81 178 134662 38647 50431637
Respiratory disorder neonatal 21.99 9.81 19 134821 922 50469362
Prolonged expiration 21.99 9.81 17 134823 704 50469580
Hyperthermia 21.78 9.81 57 134783 7639 50462645
Diet failure 21.74 9.81 7 134833 37 50470247
Sepsis 21.62 9.81 238 134602 132687 50337597
Gallbladder disorder 21.43 9.81 95 134745 16647 50453637
Psychomotor retardation 21.23 9.81 35 134805 3383 50466901
Neonatal complications of substance abuse 21.20 9.81 5 134835 5 50470279
Infantile apnoea 21.16 9.81 18 134822 855 50469429
Induced abortion failed 21.15 9.81 11 134829 224 50470060
Myelosuppression 21.15 9.81 5 134835 13512 50456772
Eye movement disorder 21.11 9.81 41 134799 4504 50465780
Bipolar I disorder 21.02 9.81 23 134817 1495 50468789
Emotional poverty 20.83 9.81 12 134828 301 50469983
Dissociation 20.76 9.81 28 134812 2263 50468021
Neonatal hypoxia 20.70 9.81 14 134826 469 50469815
Eating disorder symptom 20.53 9.81 9 134831 123 50470161
Borderline personality disorder 20.50 9.81 16 134824 672 50469612
CYP3A4 polymorphism 20.47 9.81 8 134832 80 50470204
Disorientation 20.34 9.81 163 134677 35321 50434963
Brugada syndrome 20.24 9.81 12 134828 318 50469966
Aortic bruit 19.99 9.81 6 134834 24 50470260
Tongue biting 19.91 9.81 21 134819 1309 50468975
Gestational diabetes 19.83 9.81 54 134786 7411 50462873
Drug use disorder 19.82 9.81 32 134808 3040 50467244
IIIrd nerve paresis 19.78 9.81 9 134831 135 50470149
Posterior segment of eye anomaly congenital 19.72 9.81 4 134836 0 50470284
Leukocytosis 19.68 9.81 115 134725 22464 50447820
Feeling jittery 19.67 9.81 70 134770 11090 50459194
Patent ductus arteriosus 19.66 9.81 36 134804 3784 50466500
Dizziness 19.44 9.81 1118 133722 345251 50125033
Procedural hypertension 19.38 9.81 11 134829 268 50470016
Small for dates baby 19.27 9.81 34 134806 3471 50466813
Slow response to stimuli 19.21 9.81 17 134823 852 50469432
Dysphemia 19.11 9.81 27 134813 2279 50468005
Joint range of motion decreased 19.00 9.81 13 134827 18499 50451785
Hypomania 18.96 9.81 39 134801 4466 50465818
Neonatal asphyxia 18.95 9.81 10 134830 210 50470074
Sleep-related eating disorder 18.95 9.81 16 134824 752 50469532
Posterior reversible encephalopathy syndrome 18.95 9.81 8 134832 14920 50455364
Ventricular tachycardia 18.93 9.81 88 134752 15733 50454551
Homicidal ideation 18.88 9.81 23 134817 1679 50468605
Drug eruption 18.87 9.81 21 134819 23585 50446699
Primitive reflex test positive 18.87 9.81 5 134835 11 50470273
Optic ischaemic neuropathy 18.79 9.81 18 134822 999 50469285
Electrolyte depletion 18.77 9.81 9 134831 153 50470131
Ideas of reference 18.75 9.81 8 134832 102 50470182
Road traffic accident 18.68 9.81 120 134720 24232 50446052
Developmental delay 18.61 9.81 20 134820 1274 50469010
Constipation 18.51 9.81 366 134474 185342 50284942
Gastric bypass 18.44 9.81 21 134819 1427 50468857
Post-traumatic neck syndrome 18.31 9.81 24 134816 1886 50468398
Spinal shock 18.28 9.81 5 134835 13 50470271
Osteonecrosis of jaw 18.18 9.81 37 134803 32489 50437795
Gaze palsy 18.12 9.81 20 134820 1313 50468971
Maternal exposure during pregnancy 18.08 9.81 308 134532 159470 50310814
Anterograde amnesia 17.90 9.81 13 134827 489 50469795
Psychomotor hyperactivity 17.84 9.81 60 134780 9241 50461043
Blood pressure measurement 17.79 9.81 10 134830 239 50470045
Heart disease congenital 17.72 9.81 19 134821 1207 50469077
Somnambulism 17.71 9.81 40 134800 4884 50465400
Blood pressure systolic increased 17.63 9.81 43 134797 35406 50434878
Atelectasis neonatal 17.52 9.81 5 134835 16 50470268
pH body fluid increased 17.49 9.81 4 134836 3 50470281
Oppositional defiant disorder 17.47 9.81 6 134834 40 50470244
Drug screen positive 17.43 9.81 32 134808 3370 50466914
Loss of consciousness 17.42 9.81 382 134458 103971 50366313
Bruxism 17.38 9.81 30 134810 3010 50467274
Drug hypersensitivity 17.28 9.81 523 134317 250487 50219797
Neuroleptic malignant syndrome 17.27 9.81 67 134773 11063 50459221
Atrioventricular block second degree 17.23 9.81 33 134807 3588 50466696
Sudden onset of sleep 17.23 9.81 13 134827 519 50469765
Personality change 17.21 9.81 43 134797 5602 50464682
Disturbance in sexual arousal 17.16 9.81 7 134833 79 50470205
Liver function test increased 17.15 9.81 26 134814 25580 50444704
Prolonged labour 16.97 9.81 13 134827 531 50469753
Cholecystectomy 16.96 9.81 59 134781 9244 50461040
Supraventricular tachyarrhythmia 16.86 9.81 7 134833 83 50470201
Balance disorder 16.82 9.81 273 134567 70317 50399967
Acute respiratory distress syndrome 16.82 9.81 105 134735 20994 50449290
Influenza like illness 16.73 9.81 230 134610 57229 50413055
Chronic fatigue syndrome 16.68 9.81 17 134823 1018 50469266
Energy increased 16.68 9.81 25 134815 2227 50468057
Hallucinations, mixed 16.66 9.81 35 134805 4068 50466216
Pruritus 16.65 9.81 603 134237 282965 50187319
Congenital brain damage 16.49 9.81 4 134836 5 50470279
Hyperkalaemia 16.44 9.81 69 134771 48020 50422264
Nervousness 16.39 9.81 128 134712 27523 50442761
Affective disorder 16.36 9.81 40 134800 5141 50465143
Serum sickness-like reaction 16.35 9.81 12 134828 459 50469825
Hypercalcaemia 16.34 9.81 23 134817 23329 50446955
Prolonged rupture of membranes 16.31 9.81 6 134834 50 50470234
Regurgitation 16.27 9.81 19 134821 1327 50468957
Placenta praevia 16.09 9.81 16 134824 930 50469354
Hypersomnia 16.04 9.81 82 134758 15232 50455052
Withdrawal catatonia 16.01 9.81 6 134834 53 50470231
Palmar-plantar erythrodysaesthesia syndrome 15.93 9.81 18 134822 20080 50450204
Agonal rhythm 15.93 9.81 5 134835 24 50470260
Pulmonary vasculitis 15.91 9.81 6 134834 54 50470230
Blunted affect 15.87 9.81 9 134831 219 50470065
Accidental exposure to product 15.84 9.81 23 134817 23034 50447250
Emotional disorder 15.79 9.81 68 134772 11768 50458516
Eosinophilic pneumonia acute 15.76 9.81 10 134830 300 50469984
Loss of bladder sensation 15.76 9.81 5 134835 25 50470259
Tachyphrenia 15.76 9.81 18 134822 1227 50469057
Polydactyly 15.73 9.81 10 134830 301 50469983
Libido decreased 15.67 9.81 25 134815 2351 50467933
Nystagmus 15.55 9.81 41 134799 5520 50464764
Obsessive thoughts 15.52 9.81 12 134828 497 50469787
Paraesthesia 15.51 9.81 425 134415 119818 50350466
Breast enlargement 15.50 9.81 19 134821 1396 50468888
Analgesic drug level increased 15.45 9.81 21 134819 1710 50468574
Breast discomfort 15.43 9.81 11 134829 402 50469882
Toxic epidermal necrolysis 15.37 9.81 20 134820 20972 50449312
Alcohol withdrawal syndrome 15.37 9.81 14 134826 729 50469555
Fluid retention 15.33 9.81 76 134764 50573 50419711
Hepatic function abnormal 15.21 9.81 41 134799 32640 50437644
Plasma cell mastitis 15.15 9.81 5 134835 29 50470255
Phobia 15.14 9.81 10 134830 322 50469962
Sleep paralysis 15.05 9.81 12 134828 520 50469764
Psoriasis 15.03 9.81 263 134577 68737 50401547
Tooth hypoplasia 14.93 9.81 6 134834 65 50470219
Acute myeloid leukaemia 14.92 9.81 11 134829 15063 50455221
Intrusive thoughts 14.91 9.81 8 134832 174 50470110
Oesophageal food impaction 14.91 9.81 8 134832 174 50470110
Staring 14.88 9.81 19 134821 1455 50468829
Leukopenia 14.85 9.81 112 134728 67416 50402868
Parkinsonian gait 14.76 9.81 11 134829 431 50469853
Formication 14.69 9.81 31 134809 3615 50466669
Polyneuropathy 14.62 9.81 7 134833 12124 50458160
Alcohol use 14.57 9.81 22 134818 1973 50468311
Skin ulcer 14.48 9.81 47 134793 35271 50435013
Peritonitis 14.45 9.81 12 134828 15474 50454810
Chemical burn 14.38 9.81 10 134830 351 50469933
Feeling of despair 14.37 9.81 22 134818 1996 50468288
Umbilical cord around neck 14.28 9.81 8 134832 190 50470094
Psychotic behaviour 14.27 9.81 12 134828 561 50469723
Device placement issue 14.25 9.81 14 134826 802 50469482
Microcephaly 14.25 9.81 14 134826 802 50469482
Bipolar disorder 14.23 9.81 45 134795 6712 50463572
Hypoprolactinaemia 14.21 9.81 4 134836 12 50470272
Hyporesponsive to stimuli 14.20 9.81 15 134825 937 50469347
Transplant rejection 14.18 9.81 4 134836 9605 50460679
Bradykinesia 14.15 9.81 32 134808 3911 50466373
Cleft palate 14.05 9.81 15 134825 948 50469336
Gait disturbance 14.03 9.81 510 134330 149495 50320789
Decreased interest 14.01 9.81 27 134813 2949 50467335
Cold agglutinins positive 13.99 9.81 5 134835 38 50470246
Muscle enzyme increased 13.99 9.81 7 134833 131 50470153
Congenital multiplex arthrogryposis 13.97 9.81 4 134836 13 50470271
Mononucleosis syndrome 13.90 9.81 7 134833 133 50470151
Transient aphasia 13.88 9.81 5 134835 39 50470245
Hypnopompic hallucination 13.88 9.81 5 134835 39 50470245
Sluggishness 13.86 9.81 34 134806 4379 50465905
Pre-existing condition improved 13.80 9.81 46 134794 7051 50463233
Purple glove syndrome 13.74 9.81 8 134832 205 50470079
Anhedonia 13.71 9.81 56 134784 9468 50460816
Bone erosion 13.70 9.81 7 134833 11680 50458604
Coordination abnormal 13.68 9.81 64 134776 11470 50458814
Brucellosis 13.67 9.81 5 134835 41 50470243
Basilar migraine 13.67 9.81 5 134835 41 50470243
Cholelithiasis 13.61 9.81 158 134682 37815 50432469
Pericardial effusion 13.56 9.81 30 134810 25559 50444725
Floppy infant 13.56 9.81 6 134834 84 50470200
Negative thoughts 13.55 9.81 14 134826 852 50469432
Hypouricaemia 13.53 9.81 7 134833 141 50470143
Binge eating 13.52 9.81 10 134830 387 50469897
Hospitalisation 13.41 9.81 116 134724 67821 50402463
Post-traumatic stress disorder 13.35 9.81 33 134807 4270 50466014
Sudden cardiac death 13.35 9.81 21 134819 1951 50468333
Back pain 13.34 9.81 466 134374 219564 50250720
Dermatillomania 13.23 9.81 7 134833 148 50470136
Drug tolerance decreased 13.17 9.81 4 134836 9156 50461128
Ventricular arrhythmia 13.17 9.81 28 134812 3281 50467003
Amenorrhoea 13.10 9.81 51 134789 8433 50461851
Biliary dyskinesia 13.08 9.81 24 134816 2526 50467758
Device related infection 13.00 9.81 22 134818 20713 50449571
Feeling guilty 12.99 9.81 11 134829 519 50469765
Depersonalisation/derealisation disorder 12.98 9.81 16 134824 1182 50469102
Tension 12.93 9.81 25 134815 2737 50467547
General physical condition abnormal 12.93 9.81 29 134811 3524 50466760
Sensation of blood flow 12.89 9.81 5 134835 49 50470235
Amaurosis 12.81 9.81 11 134829 529 50469755
Heavy menstrual bleeding 12.81 9.81 78 134762 15459 50454825
Cataplexy 12.80 9.81 15 134825 1051 50469233
Jaw clicking 12.78 9.81 4 134836 19 50470265
Pregnancy with advanced maternal age 12.72 9.81 3 134837 3 50470281
Potentiating drug interaction 12.63 9.81 30 134810 3786 50466498
Platelet dysfunction 12.62 9.81 6 134834 100 50470184
Oesophageal adenocarcinoma 12.62 9.81 7 134833 163 50470121
Craniosynostosis 12.58 9.81 7 134833 164 50470120
Therapeutic response decreased 12.56 9.81 74 134766 47157 50423127
Ascites 12.54 9.81 51 134789 35810 50434474
Hypoxic-ischaemic encephalopathy 12.49 9.81 30 134810 3812 50466472
Fear of weight gain 12.45 9.81 4 134836 21 50470263
Neonatal disorder 12.43 9.81 11 134829 551 50469733
Gastrointestinal haemorrhage 12.43 9.81 130 134710 73191 50397093
Feeling drunk 12.40 9.81 29 134811 3624 50466660
Liver disorder 12.36 9.81 54 134786 37168 50433116
Thrombotic microangiopathy 12.36 9.81 4 134836 8787 50461497
Metastases to bone 12.32 9.81 18 134822 17977 50452307
Duodenal ulcer repair 12.29 9.81 5 134835 56 50470228
Panic disorder 12.23 9.81 22 134818 2281 50468003
Appetite disorder 12.22 9.81 40 134800 6074 50464210
Personality disorder 12.21 9.81 32 134808 4292 50465992
Blood bilirubin increased 12.21 9.81 44 134796 31994 50438290
Haematotoxicity 12.20 9.81 3 134837 7892 50462392
Incubator therapy 12.15 9.81 4 134836 23 50470261
Medical diet 12.15 9.81 4 134836 23 50470261
Skin infection 12.13 9.81 9 134831 12282 50458002
Bradycardia neonatal 12.03 9.81 13 134827 833 50469451
Ketonuria 11.99 9.81 10 134830 462 50469822
Pleurothotonus 11.94 9.81 16 134824 1285 50468999
Infantile vomiting 11.87 9.81 6 134834 115 50470169
Anorexia nervosa 11.83 9.81 7 134833 185 50470099
Panniculitis 11.72 9.81 4 134836 8499 50461785
Anal incontinence 11.67 9.81 61 134779 11429 50458855
Areflexia 11.62 9.81 24 134816 2756 50467528
Antidepressant drug level above therapeutic 11.61 9.81 9 134831 374 50469910
Osteoporosis 11.58 9.81 71 134769 44808 50425476
Oxygen saturation decreased 11.57 9.81 132 134708 73116 50397168
Social avoidant behaviour 11.52 9.81 24 134816 2773 50467511
Renal adenoma 11.51 9.81 3 134837 6 50470278
Hyperinsulinism 11.51 9.81 3 134837 6 50470278
Carotid arterial embolus 11.51 9.81 3 134837 6 50470278
Ventricular septal defect 11.51 9.81 30 134810 4011 50466273
Myasthenic syndrome 11.50 9.81 7 134833 195 50470089
Job dissatisfaction 11.48 9.81 4 134836 28 50470256
Gambling disorder 11.44 9.81 15 134825 1179 50469105
Tenosynovitis 11.41 9.81 7 134833 10558 50459726
Joint hyperextension 11.35 9.81 8 134832 287 50469997
Creatinine renal clearance decreased 11.34 9.81 9 134831 11872 50458412
Economic problem 11.33 9.81 19 134821 1863 50468421
Confabulation 11.32 9.81 8 134832 288 50469996
Product use in unapproved indication 11.31 9.81 229 134611 115590 50354694
Sleep disorder 11.31 9.81 215 134625 57068 50413216
Theft 11.30 9.81 5 134835 70 50470214
Hypnagogic hallucination 11.29 9.81 6 134834 128 50470156
Foetal arrhythmia 11.29 9.81 6 134834 128 50470156
Pulmonary valve incompetence 11.26 9.81 15 134825 1198 50469086
Social anxiety disorder 11.25 9.81 9 134831 392 50469892
Neonatal respiratory distress 11.23 9.81 8 134832 292 50469992
Fall 11.20 9.81 1037 133803 333895 50136389
Spina bifida occulta 11.20 9.81 3 134837 7 50470277
Unmasking of previously unidentified disease 11.14 9.81 12 134828 766 50469518
Lymphocytic hypophysitis 11.12 9.81 7 134833 207 50470077
Substance abuse 11.12 9.81 30 134810 4094 50466190
Hypometabolism 11.02 9.81 4 134836 32 50470252
Injection site pain 11.00 9.81 219 134621 110805 50359479
Yawning 10.99 9.81 13 134827 920 50469364
Acute stress disorder 10.98 9.81 7 134833 212 50470072
Proteinuria 10.97 9.81 17 134823 16580 50453704
Postural tremor 10.92 9.81 7 134833 214 50470070
Dissociative identity disorder 10.87 9.81 5 134835 77 50470207
Neutropenic sepsis 10.86 9.81 13 134827 14134 50456150
Death of relative 10.83 9.81 7 134833 217 50470067
Apgar score low 10.79 9.81 11 134829 659 50469625
Spasmodic dysphonia 10.76 9.81 5 134835 79 50470205
Complication of device insertion 10.74 9.81 38 134802 6003 50464281
Jaundice neonatal 10.73 9.81 12 134828 799 50469485
Pregnancy on oral contraceptive 10.72 9.81 13 134827 945 50469339
Pleural disorder 10.70 9.81 10 134830 538 50469746
Cytopenia 10.67 9.81 5 134835 8770 50461514
Tooth demineralisation 10.66 9.81 3 134837 9 50470275
Thought insertion 10.66 9.81 3 134837 9 50470275
Dysmorphism 10.62 9.81 20 134820 2147 50468137
Obsessive-compulsive symptom 10.61 9.81 4 134836 36 50470248
Muscle neoplasm 10.61 9.81 4 134836 36 50470248
Dermatitis atopic 10.60 9.81 27 134813 3559 50466725
Enthesopathy 10.60 9.81 3 134837 7190 50463094
Sleep attacks 10.59 9.81 5 134835 82 50470202
Respiratory disorder 10.50 9.81 45 134795 31142 50439142
Diverticulitis 10.50 9.81 49 134791 33133 50437151
Lactation disorder 10.46 9.81 8 134832 326 50469958
Autonomic nervous system imbalance 10.46 9.81 21 134819 2364 50467920
Antisocial personality disorder 10.42 9.81 3 134837 10 50470274
Oedema peripheral 10.40 9.81 331 134509 157630 50312654
Hypertonic bladder 10.38 9.81 24 134816 2976 50467308
Superior mesenteric artery syndrome 10.37 9.81 5 134835 86 50470198
Multiple organ dysfunction syndrome 10.36 9.81 85 134755 50252 50420032
Blood pressure diastolic decreased 10.34 9.81 18 134822 16763 50453521
Gallbladder neoplasm 10.33 9.81 4 134836 39 50470245
Bacteraemia 10.31 9.81 14 134826 14419 50455865
Extensor plantar response 10.30 9.81 14 134826 1140 50469144
Dental restoration failure 10.29 9.81 10 134830 565 50469719
Neutrophil count decreased 10.28 9.81 76 134764 45950 50424334
Pyloric stenosis 10.27 9.81 8 134832 335 50469949
Lymphatic system neoplasm 10.24 9.81 4 134836 40 50470244
Pulmonary artery stenosis congenital 10.23 9.81 7 134833 239 50470045
Metastases to central nervous system 10.21 9.81 9 134831 11273 50459011
Treatment noncompliance 10.17 9.81 124 134716 30026 50440258
Blood triglycerides increased 10.11 9.81 58 134782 11254 50459030
Embolism 10.10 9.81 3 134837 6965 50463319
Asthenia 10.08 9.81 723 134117 318319 50151965
Apnoea 10.06 9.81 41 134799 6925 50463359
Multiple allergies 10.02 9.81 5 134835 8458 50461826
Joint effusion 9.96 9.81 12 134828 13009 50457275
Productive cough 9.95 9.81 91 134749 52603 50417681
Blood urea increased 9.94 9.81 31 134809 23554 50446730
Micturition urgency 9.91 9.81 46 134794 8218 50462066
Haemorrhage intracranial 9.90 9.81 11 134829 12363 50457921
Electrocardiogram repolarisation abnormality 9.87 9.81 14 134826 1186 50469098

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 878.30 10.68 502 57794 17010 29499221
Suicidal ideation 418.86 10.68 424 57872 34292 29481939
Completed suicide 376.01 10.68 653 57643 89593 29426638
Toxicity to various agents 349.86 10.68 935 57361 172726 29343505
Suicide attempt 339.30 10.68 376 57920 33734 29482497
Intentional overdose 305.38 10.68 378 57918 38150 29478081
Drug interaction 260.66 10.68 917 57379 196468 29319763
Obsessive-compulsive disorder 244.87 10.68 137 58159 4439 29511792
Akathisia 210.18 10.68 143 58153 6599 29509632
Anxiety 181.83 10.68 470 57826 84895 29431336
Euphoric mood 159.16 10.68 106 58190 4719 29511512
Agitation 155.98 10.68 325 57971 50979 29465252
Aggression 153.96 10.68 262 58034 35279 29480952
Overdose 144.44 10.68 414 57882 79405 29436826
Drug abuse 140.37 10.68 410 57886 79473 29436758
Antipsychotic drug level below therapeutic 139.11 10.68 71 58225 1903 29514328
Drug withdrawal syndrome 133.69 10.68 171 58125 17813 29498418
Therapeutic product effect variable 127.90 10.68 66 58230 1811 29514420
Depression 125.44 10.68 411 57885 84736 29431495
Homicide 123.91 10.68 52 58244 876 29515355
Disinhibition 123.25 10.68 72 58224 2535 29513696
Febrile neutropenia 113.11 10.68 40 58256 112200 29404031
Increased appetite 109.81 10.68 93 58203 5971 29510260
Pneumonia 93.25 10.68 322 57974 319850 29196381
Electrocardiogram QT prolonged 92.82 10.68 214 58082 35923 29480308
Psychotic disorder 86.72 10.68 149 58147 20205 29496026
Depressed mood 85.83 10.68 132 58164 16316 29499915
Drug dependence 84.72 10.68 150 58146 20831 29495400
Pyrexia 79.87 10.68 295 58001 287327 29228904
Irritability 78.88 10.68 150 58146 22002 29494229
Paranoia 78.29 10.68 97 58199 9780 29506451
Anaemia 75.33 10.68 179 58117 200772 29315459
Sepsis 75.06 10.68 103 58193 142579 29373652
Malignant neoplasm progression 74.92 10.68 26 58270 73833 29442398
Exposure during pregnancy 74.31 10.68 88 58208 8466 29507765
Poisoning 71.09 10.68 93 58203 9900 29506331
Obesity 70.49 10.68 92 58204 9771 29506460
Mania 68.54 10.68 85 58211 8578 29507653
Intentional self-injury 66.42 10.68 101 58195 12360 29503871
Suicidal behaviour 65.32 10.68 38 58258 1327 29514904
Intentional product misuse 63.77 10.68 181 58115 34480 29481751
Tardive dyskinesia 62.90 10.68 64 58232 5194 29511037
Thrombocytopenia 62.55 10.68 106 58190 134717 29381514
Tremor 59.05 10.68 294 58002 73244 29442987
Anger 57.66 10.68 88 58208 10802 29505429
Platelet count decreased 57.63 10.68 73 58223 104599 29411632
Drug withdrawal syndrome neonatal 57.26 10.68 50 58246 3345 29512886
Weight increased 57.02 10.68 300 57996 76367 29439864
Victim of child abuse 55.53 10.68 29 58267 816 29515415
Sedation 54.87 10.68 112 58184 17293 29498938
Muscle twitching 54.48 10.68 73 58223 7953 29508278
Hyperreflexia 53.26 10.68 44 58252 2728 29513503
Social avoidant behaviour 53.02 10.68 45 58251 2897 29513334
Abnormal behaviour 52.93 10.68 131 58165 22996 29493235
Disease progression 51.80 10.68 51 58245 81865 29434366
Dyskinesia 50.60 10.68 118 58178 19943 29496288
Diarrhoea 50.49 10.68 417 57879 332281 29183950
Sexual dysfunction 49.16 10.68 59 58237 5755 29510476
Hallucination, auditory 48.66 10.68 76 58220 9517 29506714
Tic 48.06 10.68 35 58261 1800 29514431
Disturbance in attention 47.61 10.68 120 58176 21304 29494927
Synaesthesia 47.08 10.68 9 58287 0 29516231
Parasomnia 47.01 10.68 20 58276 349 29515882
General physical health deterioration 45.74 10.68 83 58213 102774 29413457
Haemoglobin decreased 45.10 10.68 91 58205 108284 29407947
Nightmare 42.73 10.68 79 58217 11338 29504893
Withdrawal syndrome 42.33 10.68 77 58219 10915 29505316
Extrapyramidal disorder 41.87 10.68 76 58220 10755 29505476
Mental disorder 41.81 10.68 84 58212 12821 29503410
Pancytopenia 41.74 10.68 62 58234 83106 29433125
Atrial fibrillation 41.20 10.68 92 58204 105554 29410677
Myoclonus 41.19 10.68 85 58211 13224 29503007
Bipolar disorder 41.05 10.68 41 58255 3254 29512977
Visceral congestion 40.89 10.68 20 58276 488 29515743
Renal impairment 40.46 10.68 61 58235 81272 29434959
Tremor neonatal 40.44 10.68 18 58278 352 29515879
Antipsychotic drug level increased 39.75 10.68 40 58256 3203 29513028
Insomnia 39.61 10.68 305 57991 88456 29427775
Panic attack 39.53 10.68 64 58232 8262 29507969
Hepatic function abnormal 39.48 10.68 14 58282 39245 29476986
Drug abuser 39.40 10.68 43 58253 3784 29512447
Infection 38.73 10.68 57 58239 76694 29439537
Asphyxia 38.63 10.68 50 58246 5265 29510966
Depersonalisation/derealisation disorder 38.35 10.68 20 58276 561 29515670
Homicidal ideation 38.26 10.68 35 58261 2489 29513742
Prescribed overdose 37.54 10.68 64 58232 8619 29507612
Rash 37.53 10.68 220 58076 189599 29326632
Thinking abnormal 36.11 10.68 48 58248 5188 29511043
Chorea 35.89 10.68 23 58273 958 29515273
Maternal drugs affecting foetus 35.39 10.68 41 58255 3852 29512379
Blood prolactin increased 35.14 10.68 27 58269 1507 29514724
Delusion 35.14 10.68 72 58224 11144 29505087
Somnolence 35.03 10.68 310 57986 93645 29422586
Hyperhidrosis 34.71 10.68 232 58064 64308 29451923
Neutropenia 33.91 10.68 139 58157 131572 29384659
Abnormal sleep-related event 33.88 10.68 17 58279 439 29515792
Acute kidney injury 33.87 10.68 347 57949 264920 29251311
Mast cell activation syndrome 33.76 10.68 13 58283 173 29516058
Seizure 33.05 10.68 304 57992 92819 29423412
Apathy 32.85 10.68 50 58246 6121 29510110
Bone marrow failure 32.81 10.68 7 58289 27442 29488789
Torsade de pointes 32.71 10.68 52 58244 6609 29509622
Respiratory depression 32.43 10.68 78 58218 13445 29502786
Generalised tonic-clonic seizure 32.36 10.68 97 58199 19042 29497189
Priapism 32.28 10.68 42 58254 4446 29511785
Mucosal inflammation 32.23 10.68 11 58285 31584 29484647
Affective disorder 31.96 10.68 35 58261 3091 29513140
Product complaint 31.95 10.68 46 58250 5359 29510872
Tearfulness 31.50 10.68 26 58270 1610 29514621
Stomatitis 31.37 10.68 17 58279 37096 29479135
Neuroleptic malignant syndrome 31.33 10.68 86 58210 16062 29500169
Nervousness 31.29 10.68 69 58227 11237 29504994
Restless legs syndrome 30.89 10.68 52 58244 6932 29509299
Mood swings 30.76 10.68 53 58243 7198 29509033
Dyslipidaemia 30.71 10.68 48 58248 6013 29510218
Dissociation 30.63 10.68 22 58274 1107 29515124
Social anxiety disorder 30.60 10.68 13 58283 226 29516005
Oral discharge 30.53 10.68 11 58285 120 29516111
Choreoathetosis 30.28 10.68 21 58275 999 29515232
Sleep disorder 30.00 10.68 111 58185 24275 29491956
Rhabdomyolysis 29.98 10.68 214 58082 60594 29455637
Poisoning deliberate 29.90 10.68 46 58250 5685 29510546
Cytomegalovirus infection 29.71 10.68 5 58291 23210 29493021
Major depression 29.33 10.68 37 58259 3798 29512433
Septic shock 29.14 10.68 49 58247 62511 29453720
Persistent foetal circulation 29.10 10.68 14 58282 329 29515902
Antidepressant drug level increased 28.89 10.68 10 58286 96 29516135
Memory impairment 28.67 10.68 145 58151 36325 29479906
Abnormal dreams 28.60 10.68 50 58246 6870 29509361
Hallucination 28.57 10.68 168 58128 44544 29471687
Bruxism 28.03 10.68 24 58272 1563 29514668
Huntington's disease 27.76 10.68 8 58288 39 29516192
Serum ferritin abnormal 27.67 10.68 12 58284 220 29516011
Impulsive behaviour 27.63 10.68 26 58270 1917 29514314
Libido decreased 27.51 10.68 38 58258 4260 29511971
Derealisation 27.39 10.68 16 58280 563 29515668
Congenital aortic valve stenosis 26.82 10.68 10 58286 121 29516110
Rheumatoid arthritis 26.78 10.68 15 58281 32137 29484094
Clonus 26.74 10.68 28 58268 2350 29513881
Coma 26.35 10.68 150 58146 39300 29476931
Interstitial lung disease 26.16 10.68 46 58250 57672 29458559
Alcoholism 25.84 10.68 29 58267 2632 29513599
Accidental death 25.73 10.68 26 58270 2092 29514139
Cyanosis neonatal 25.46 10.68 12 58284 269 29515962
Gastrointestinal haemorrhage 25.08 10.68 77 58219 79456 29436775
Neonatal disorder 24.94 10.68 17 58279 786 29515445
Accommodation disorder 24.91 10.68 11 58285 211 29516020
Oculogyric crisis 24.90 10.68 21 58275 1340 29514891
Initial insomnia 24.85 10.68 29 58267 2746 29513485
Foetal exposure during pregnancy 24.78 10.68 132 58164 33735 29482496
Renal failure 24.73 10.68 135 58161 118464 29397767
Respiratory failure 24.67 10.68 103 58193 97028 29419203
Schizoaffective disorder 24.53 10.68 19 58277 1073 29515158
Antisocial behaviour 24.38 10.68 12 58284 297 29515934
Epidural lipomatosis 24.36 10.68 16 58280 695 29515536
Gambling disorder 24.19 10.68 22 58274 1553 29514678
Violence-related symptom 23.96 10.68 14 58282 493 29515738
Alcohol poisoning 23.94 10.68 30 58266 3059 29513172
Dreamy state 23.90 10.68 6 58290 15 29516216
Hyperdynamic left ventricle 23.77 10.68 9 58287 114 29516117
Hyperkalaemia 23.48 10.68 54 58242 61338 29454893
Cardiac failure 23.44 10.68 79 58217 79208 29437023
Restlessness 23.33 10.68 96 58200 22049 29494182
Treatment failure 23.33 10.68 23 58273 36916 29479315
Pleural effusion 23.11 10.68 69 58227 71839 29444392
Feeling jittery 23.07 10.68 32 58264 3601 29512630
Vasoplegia syndrome 23.03 10.68 21 58275 1487 29514744
Neuropathy peripheral 22.94 10.68 68 58228 70959 29445272
Electrocardiogram QRS complex prolonged 22.87 10.68 34 58262 4076 29512155
Eye movement disorder 22.65 10.68 32 58264 3664 29512567
Juvenile idiopathic arthritis 22.45 10.68 20 58276 1374 29514857
Hostility 22.35 10.68 16 58280 801 29515430
Herpes zoster 22.31 10.68 16 58280 30036 29486195
Pulmonary embolism 22.12 10.68 77 58219 76457 29439774
Cardiac arrest 22.11 10.68 262 58034 85329 29430902
Disseminated intravascular coagulation 22.10 10.68 6 58290 19974 29496257
Product substitution issue 22.09 10.68 53 58243 9119 29507112
Mood altered 21.88 10.68 49 58247 8062 29508169
Myocardial infarction 21.67 10.68 128 58168 110168 29406063
Blunted affect 21.34 10.68 11 58285 301 29515930
Obsessive thoughts 21.32 10.68 14 58282 608 29515623
Muscle rigidity 21.20 10.68 53 58243 9358 29506873
Serum serotonin decreased 20.93 10.68 4 58292 0 29516231
Parkinsonism 20.80 10.68 45 58251 7233 29508998
Flat affect 20.50 10.68 15 58281 777 29515454
Neonatal respiratory distress syndrome 20.47 10.68 31 58265 3779 29512452
Off label use 20.40 10.68 445 57851 300355 29215876
Vascular stenosis 20.36 10.68 9 58287 173 29516058
White blood cell count decreased 20.19 10.68 90 58206 83272 29432959
Lethargy 20.13 10.68 135 58161 37445 29478786
Dystonia 20.00 10.68 53 58243 9696 29506535
Compulsions 19.99 10.68 9 58287 181 29516050
Poor quality sleep 19.85 10.68 44 58252 7189 29509042
Respiratory arrest 19.80 10.68 102 58194 25731 29490500
Hypersomnia 19.61 10.68 56 58240 10698 29505533
Emotional disorder 19.57 10.68 35 58261 4896 29511335
Drug level increased 19.44 10.68 81 58215 18706 29497525
Cholinergic syndrome 19.29 10.68 12 58284 474 29515757
Psychomotor hyperactivity 19.29 10.68 47 58249 8166 29508065
Loss of employment 19.27 10.68 12 58284 475 29515756
Yawning 19.20 10.68 12 58284 478 29515753
Compulsive shopping 18.94 10.68 11 58285 383 29515848
Hypoglycaemia neonatal 18.85 10.68 20 58276 1704 29514527
Negative thoughts 18.83 10.68 13 58283 614 29515617
Self-injurious ideation 18.77 10.68 19 58277 1532 29514699
Agitation neonatal 18.72 10.68 16 58280 1040 29515191
Erythema 18.69 10.68 81 58215 75525 29440706
Dyspnoea 18.68 10.68 496 57800 326236 29189995
Pneumocystis jirovecii pneumonia 18.63 10.68 5 58291 16774 29499457
Compulsive hoarding 18.56 10.68 5 58291 18 29516213
Peripheral swelling 18.50 10.68 64 58232 63675 29452556
Physical deconditioning 18.45 10.68 14 58282 767 29515464
Pituitary tumour benign 18.37 10.68 14 58282 772 29515459
Somnambulism 18.30 10.68 25 58271 2773 29513458
Congenital aortic valve incompetence 18.28 10.68 8 58288 150 29516081
Premature baby 18.28 10.68 75 58221 17205 29499026
Renal ischaemia 18.20 10.68 12 58284 525 29515706
Retinal phototoxicity 18.16 10.68 4 58292 4 29516227
Infusion related reaction 18.10 10.68 37 58259 43849 29472382
Schizophrenia 18.09 10.68 40 58256 6525 29509706
Chronic actinic dermatitis 17.95 10.68 5 58291 21 29516210
COVID-19 17.91 10.68 27 58269 35987 29480244
Mydriasis 17.82 10.68 38 58258 6047 29510184
Leukaemia 17.69 10.68 29 58267 3781 29512450
Small for dates baby 17.66 10.68 28 58268 3551 29512680
Arthralgia 17.61 10.68 183 58113 139434 29376797
Lymphocyte count decreased 17.53 10.68 8 58288 19263 29496968
Cognitive disorder 17.47 10.68 92 58204 23407 29492824
Loss of libido 17.32 10.68 22 58274 2274 29513957
Tachyphrenia 17.31 10.68 16 58280 1153 29515078
Urinary tract discomfort 17.18 10.68 7 58289 109 29516122
Colitis 16.96 10.68 22 58274 31226 29485005
Pain 16.93 10.68 237 58059 171195 29345036
Ascites 16.75 10.68 29 58267 36590 29479641
Blood cholesterol increased 16.74 10.68 68 58228 15527 29500704
Liver disorder 16.70 10.68 18 58278 27731 29488500
Coagulation factor VII level decreased 16.67 10.68 7 58289 118 29516113
Neoplasm progression 16.51 10.68 8 58288 18604 29497627
Condition aggravated 16.51 10.68 391 57905 145904 29370327
Secondary hypogonadism 16.50 10.68 9 58287 277 29515954
Anaphylactic reaction 16.47 10.68 18 58278 27555 29488676
Testis cancer 16.43 10.68 14 58282 906 29515325
Selective mutism 16.29 10.68 6 58290 70 29516161
Renal artery thrombosis 16.24 10.68 9 58287 286 29515945
Alcohol use 16.14 10.68 25 58271 3107 29513124
Tourette's disorder 16.14 10.68 6 58290 72 29516159
C-reactive protein increased 16.07 10.68 40 58256 44223 29472008
Cough 16.02 10.68 166 58130 126561 29389670
Cerebral infarction 16.00 10.68 15 58281 24660 29491571
Dissociative disorder 16.00 10.68 8 58288 205 29516026
Muscle necrosis 15.87 10.68 13 58283 796 29515435
Dysphoria 15.71 10.68 20 58276 2072 29514159
Tumour lysis syndrome 15.68 10.68 4 58292 13880 29502351
Basilar migraine 15.66 10.68 4 58292 11 29516220
Pupil fixed 15.65 10.68 18 58278 1678 29514553
Feeling guilty 15.55 10.68 9 58287 311 29515920
Haematochezia 15.41 10.68 31 58265 36952 29479279
Child abuse 15.39 10.68 8 58288 223 29516008
Decreased interest 15.36 10.68 20 58276 2118 29514113
Neutrophil count decreased 15.33 10.68 40 58256 43527 29472704
Hepatic failure 15.31 10.68 24 58272 31488 29484743
Palmar-plantar erythrodysaesthesia syndrome 15.29 10.68 5 58291 14754 29501477
Autonomic nervous system imbalance 15.20 10.68 21 58275 2355 29513876
Phobia 15.14 10.68 7 58289 150 29516081
Erectile dysfunction 15.14 10.68 73 58223 17936 29498295
Coma uraemic 15.04 10.68 5 58291 42 29516189
Congenital hand malformation 15.03 10.68 11 58285 570 29515661
Obsessive-compulsive symptom 14.93 10.68 6 58290 90 29516141
Salivary hypersecretion 14.91 10.68 40 58256 7369 29508862
Transposition of the great vessels 14.91 10.68 10 58286 450 29515781
Miosis 14.89 10.68 42 58254 7967 29508264
Blood glucose fluctuation 14.88 10.68 26 58270 3571 29512660
Hyperbilirubinaemia neonatal 14.72 10.68 12 58284 730 29515501
Spina bifida 14.71 10.68 9 58287 345 29515886
Exposure via ingestion 14.69 10.68 19 58277 1999 29514232
Bipolar I disorder 14.68 10.68 12 58284 733 29515498
Ear discomfort 14.65 10.68 20 58276 2217 29514014
Feeling abnormal 14.64 10.68 168 58128 54277 29461954
Pyloric stenosis 14.61 10.68 12 58284 738 29515493
Eye colour change 14.53 10.68 8 58288 251 29515980
Post 5-alpha-reductase inhibitor syndrome 14.46 10.68 6 58290 98 29516133
Dysphemia 14.42 10.68 16 58280 1434 29514797
Cerebrovascular stenosis 14.35 10.68 6 58290 100 29516131
Joint swelling 14.29 10.68 50 58246 49580 29466651
Tongue injury 14.25 10.68 6 58290 102 29516129
Hypogonadism male 14.21 10.68 8 58288 262 29515969
Cataplexy 14.16 10.68 8 58288 264 29515967
Crying 14.07 10.68 32 58264 5319 29510912
Tension 13.91 10.68 18 58278 1895 29514336
Deep vein thrombosis 13.87 10.68 62 58234 57337 29458894
Death 13.85 10.68 543 57753 341541 29174690
Myelodysplastic syndrome 13.84 10.68 9 58287 17785 29498446
Otosalpingitis 13.80 10.68 4 58292 20 29516211
Faecal calprotectin 13.80 10.68 4 58292 20 29516211
Alpha 2 globulin decreased 13.80 10.68 4 58292 20 29516211
Blood luteinising hormone decreased 13.73 10.68 6 58290 112 29516119
Self-medication 13.72 10.68 19 58277 2135 29514096
Hypertonia neonatal 13.70 10.68 9 58287 391 29515840
Tinnitus 13.64 10.68 64 58232 15550 29500681
Free androgen index decreased 13.64 10.68 4 58292 21 29516210
Sex hormone binding globulin decreased 13.64 10.68 4 58292 21 29516210
Blood creatine phosphokinase MB 13.62 10.68 3 58293 3 29516228
Delayed sleep phase 13.62 10.68 3 58293 3 29516228
Oedema 13.62 10.68 38 58258 40445 29475786
Atrial conduction time prolongation 13.62 10.68 3 58293 3 29516228
Multiple organ dysfunction syndrome 13.61 10.68 71 58225 63045 29453186
Hypomania 13.58 10.68 19 58277 2156 29514075
Androgen insensitivity syndrome 13.48 10.68 4 58292 22 29516209
Viral acanthoma 13.48 10.68 4 58292 22 29516209
Hospitalisation 13.46 10.68 46 58250 45942 29470289
Dry mouth 13.36 10.68 81 58215 21703 29494528
Testicular microlithiasis 13.19 10.68 4 58292 24 29516207
Fear 13.18 10.68 45 58251 9459 29506772
Marital problem 13.16 10.68 5 58291 64 29516167
Blood creatinine increased 13.13 10.68 106 58190 84996 29431235
Bronchopulmonary aspergillosis 13.11 10.68 4 58292 12340 29503891
Dehydroepiandrosterone decreased 13.05 10.68 4 58292 25 29516206
Urine calcium/creatinine ratio increased 13.05 10.68 4 58292 25 29516206
Blood triglycerides increased 13.02 10.68 55 58241 12779 29503452
Arnold-Chiari malformation 12.95 10.68 8 58288 312 29515919
Logorrhoea 12.84 10.68 19 58277 2269 29513962
Suspected suicide 12.82 10.68 26 58270 3994 29512237
Retrograde ejaculation 12.82 10.68 8 58288 318 29515913
Urinary retention 12.78 10.68 107 58189 31791 29484440
Economic problem 12.70 10.68 14 58282 1246 29514985
Inflammatory bowel disease 12.69 10.68 19 58277 2292 29513939
Feeling drunk 12.64 10.68 16 58280 1648 29514583
Hypothalamic pituitary adrenal axis suppression 12.59 10.68 6 58290 138 29516093
Confusional state 12.41 10.68 335 57961 127542 29388689
Thought insertion 12.41 10.68 3 58293 6 29516225
Alpha globulin increased 12.41 10.68 3 58293 6 29516225
Chronic kidney disease 12.39 10.68 34 58262 36382 29479849
Treatment noncompliance 12.36 10.68 86 58210 24141 29492090
Panic reaction 12.21 10.68 14 58282 1301 29514930
Blood urea increased 12.20 10.68 23 58273 28089 29488142
Wrong drug 12.15 10.68 5 58291 80 29516151
Blood lactate dehydrogenase increased 12.08 10.68 12 58284 19197 29497034
Pruritus 12.08 10.68 160 58136 116689 29399542
Therapeutic response unexpected 12.06 10.68 41 58255 8597 29507634
Locked-in syndrome 12.04 10.68 7 58289 244 29515987
Atrial septal defect 12.04 10.68 35 58261 6754 29509477
Blood bilirubin increased 12.02 10.68 31 58265 33862 29482369
Cardiac failure congestive 11.99 10.68 95 58201 76486 29439745
Thrombosis 11.97 10.68 44 58252 43001 29473230
Bone marrow oedema 11.94 10.68 9 58287 488 29515743
Haemophagocytic lymphohistiocytosis 11.91 10.68 3 58293 10501 29505730
Prostate cancer 11.87 10.68 20 58276 25507 29490724
Psychiatric symptom 11.87 10.68 22 58274 3162 29513069
Cyclothymic disorder 11.87 10.68 5 58291 85 29516146
Cortisol increased 11.85 10.68 6 58290 158 29516073
Thyroxine free abnormal 11.81 10.68 3 58293 8 29516223
Creatinine urine decreased 11.79 10.68 4 58292 36 29516195
Dermal cyst 11.77 10.68 14 58282 1353 29514878
Staring 11.67 10.68 14 58282 1365 29514866
Self esteem decreased 11.62 10.68 9 58287 508 29515723
Panic disorder 11.61 10.68 13 58283 1177 29515054
Heart rate abnormal 11.48 10.68 15 58281 1594 29514637
Candida infection 11.44 10.68 8 58288 15217 29501014
Galactorrhoea 11.44 10.68 8 58288 386 29515845
Drooling 11.42 10.68 21 58275 3000 29513231
Disorientation 11.29 10.68 98 58198 29417 29486814
Retinopathy of prematurity 11.22 10.68 5 58291 98 29516133
Sinus tachycardia 11.20 10.68 59 58237 15010 29501221
Multiple sclerosis 11.19 10.68 30 58266 5524 29510707
Renal dysplasia 11.17 10.68 6 58290 179 29516052
Water intoxication 11.17 10.68 8 58288 401 29515830
Sleep apnoea syndrome 11.15 10.68 66 58230 17533 29498698
Full blood count abnormal 11.13 10.68 8 58288 15005 29501226
Carbon monoxide poisoning 11.13 10.68 5 58291 100 29516131
Terminal insomnia 11.11 10.68 8 58288 404 29515827
Genital anaesthesia 11.09 10.68 3 58293 11 29516220
Symptom masked 11.09 10.68 9 58287 544 29515687
Dyspnoea exertional 11.02 10.68 36 58260 36454 29479777
Persistent depressive disorder 10.98 10.68 7 58289 289 29515942
Ankyloglossia congenital 10.96 10.68 7 58289 290 29515941
Pulmonary congestion 10.88 10.68 51 58245 12385 29503846
Drug resistance 10.85 10.68 16 58280 21524 29494707
Urine phosphorus decreased 10.84 10.68 4 58292 47 29516184
Premature rupture of membranes 10.70 10.68 3 58293 13 29516218
Drug titration error 10.69 10.68 8 58288 429 29515802

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1809.36 9.78 2443 151704 221971 64122614
Serotonin syndrome 1230.32 9.78 900 153247 38382 64306203
Intentional overdose 1057.59 9.78 1186 152961 88758 64255827
Toxicity to various agents 991.23 9.78 2473 151674 361040 63983545
Suicidal ideation 878.75 9.78 933 153214 65609 64278976
Suicide attempt 652.29 9.78 826 153321 70181 64274404
Drug interaction 605.49 9.78 2070 152077 360013 63984572
Drug abuse 547.15 9.78 1066 153081 131308 64213277
Intentional self-injury 425.86 9.78 431 153716 28613 64315972
Electrocardiogram QT prolonged 389.72 9.78 689 153458 78759 64265826
Overdose 369.16 9.78 1023 153124 158543 64186042
Anxiety 348.70 9.78 1171 152976 201478 64143107
Agitation 310.78 9.78 666 153481 87701 64256884
Poisoning 288.91 9.78 307 153840 21572 64323013
Tremor 285.98 9.78 891 153256 147339 64197246
Drug withdrawal syndrome 280.79 9.78 360 153787 30931 64313654
Depression 275.36 9.78 1013 153134 182278 64162307
Respiratory arrest 246.29 9.78 449 153698 52536 64292049
Febrile neutropenia 222.54 9.78 85 154062 187572 64157013
Cardiac arrest 220.91 9.78 839 153308 153225 64191360
Cardio-respiratory arrest 209.95 9.78 613 153534 97780 64246805
Akathisia 206.71 9.78 191 153956 11319 64333266
Withdrawal syndrome 191.74 9.78 258 153889 23234 64321351
Aggression 186.67 9.78 369 153778 45863 64298722
Synovitis 180.59 9.78 15 154132 99075 64245510
Irritability 176.61 9.78 316 153831 36430 64308155
Suicidal behaviour 174.30 9.78 100 154047 2787 64341798
Depressed mood 167.59 9.78 329 153818 40683 64303902
Torsade de pointes 165.65 9.78 206 153941 17157 64327428
Pneumonia 164.18 9.78 734 153413 558842 63785743
Contraindicated product administered 163.35 9.78 30 154117 107799 64236786
Somnolence 162.16 9.78 934 153213 202711 64141874
Drug intolerance 160.90 9.78 128 154019 187864 64156721
Reversible cerebral vasoconstriction syndrome 151.85 9.78 85 154062 2257 64342328
Obsessive-compulsive disorder 147.55 9.78 109 154038 4709 64339876
Joint swelling 147.04 9.78 179 153968 215203 64129382
Infusion related reaction 141.97 9.78 111 154036 164356 64180229
Mania 139.26 9.78 183 153964 16103 64328482
Rheumatoid arthritis 136.68 9.78 115 154032 164179 64180406
Anaemia 132.34 9.78 463 153684 378217 63966368
Nightmare 130.99 9.78 203 153944 20790 64323795
Hand deformity 128.08 9.78 5 154142 62766 64281819
Disturbance in attention 125.69 9.78 293 153854 40781 64303804
Rash 125.20 9.78 617 153530 457932 63886653
Drug dependence 125.07 9.78 258 153889 33054 64311531
Pyrexia 124.27 9.78 804 153343 557840 63786745
Treatment failure 124.04 9.78 62 154085 116754 64227831
Panic attack 122.97 9.78 197 153950 20756 64323829
Mydriasis 120.15 9.78 165 153982 15147 64329438
Respiratory depression 119.63 9.78 207 153940 23236 64321349
Intentional product misuse 118.13 9.78 411 153736 71884 64272701
Peripheral swelling 117.87 9.78 199 153948 208954 64135631
Systemic lupus erythematosus 114.56 9.78 23 154124 77589 64266996
Infection 113.59 9.78 166 153981 184714 64159871
Muscle twitching 112.01 9.78 179 153968 18819 64325766
Coma 110.05 9.78 458 153689 87157 64257428
Seizure 109.85 9.78 729 153418 166163 64178422
Thrombocytopenia 109.38 9.78 232 153915 223569 64121016
Tardive dyskinesia 109.31 9.78 122 154025 9056 64335529
Neutropenia 109.28 9.78 258 153889 239366 64105219
Malignant neoplasm progression 108.18 9.78 68 154079 112803 64231782
Homicide 106.55 9.78 53 154094 1098 64343487
Poisoning deliberate 105.56 9.78 145 154002 13313 64331272
Pancytopenia 105.48 9.78 112 154035 143197 64201388
Platelet count decreased 102.61 9.78 151 153996 167560 64177025
Pericarditis 102.32 9.78 14 154133 62502 64282083
Abnormal behaviour 97.62 9.78 235 153912 33387 64311198
Crying 96.82 9.78 173 153974 19917 64324668
Paranoia 94.94 9.78 153 153994 16199 64328386
General physical health deterioration 94.88 9.78 218 153929 204207 64140378
Sopor 93.40 9.78 214 153933 29447 64315138
Dystonia 91.62 9.78 163 153984 18702 64325883
Off label use 90.22 9.78 1023 153124 631783 63712802
Restless legs syndrome 89.78 9.78 153 153994 16963 64327622
Self-injurious ideation 88.30 9.78 68 154079 3129 64341456
Euphoric mood 87.91 9.78 93 154054 6498 64338087
Myoclonus 87.85 9.78 189 153958 24929 64319656
Arthralgia 87.63 9.78 658 153489 441602 63902983
Muscle rigidity 87.47 9.78 153 153994 17320 64327265
Extrapyramidal disorder 86.18 9.78 162 153985 19390 64325195
Sedation 86.15 9.78 256 153891 41206 64303379
Coma scale abnormal 85.24 9.78 99 154048 7675 64336910
Sepsis 84.88 9.78 275 153872 230066 64114519
Generalised tonic-clonic seizure 84.64 9.78 248 153899 39609 64304976
Wound 83.60 9.78 39 154108 76438 64268147
Swelling 83.45 9.78 160 153987 160058 64184527
Disease progression 83.34 9.78 131 154016 141549 64203036
Electrocardiogram QRS complex prolonged 82.35 9.78 106 154041 9138 64335447
Diarrhoea 81.82 9.78 1226 152921 721478 63623107
Hyperreflexia 81.69 9.78 93 154054 7055 64337530
Anger 81.63 9.78 140 154007 15601 64328984
Tearfulness 80.93 9.78 76 154071 4597 64339988
Acute kidney injury 80.85 9.78 686 153461 448554 63896031
Renal impairment 80.22 9.78 124 154023 134893 64209692
Restlessness 80.16 9.78 243 153904 39542 64305043
Stomatitis 79.15 9.78 87 154060 109518 64235067
Psychotic disorder 79.10 9.78 221 153926 34357 64310228
Atrial fibrillation 78.13 9.78 184 153963 170905 64173680
Drug ineffective 78.02 9.78 1478 152669 838769 63505816
Hallucination, auditory 77.98 9.78 143 154004 16796 64327789
Hyperhidrosis 77.58 9.78 538 153609 124382 64220203
Tic 77.40 9.78 58 154089 2561 64342024
Nasopharyngitis 75.10 9.78 230 153917 195843 64148742
Galactorrhoea 75.08 9.78 62 154085 3157 64341428
Mucosal inflammation 74.70 9.78 28 154119 62556 64282029
Hepatic enzyme increased 74.68 9.78 122 154025 129821 64214764
Arthropathy 72.91 9.78 110 154037 120857 64223728
Clonus 72.86 9.78 81 154066 5986 64338599
Dyskinesia 72.37 9.78 233 153914 39155 64305430
Mood swings 71.18 9.78 140 154007 17328 64327257
Accidental death 69.19 9.78 63 154084 3662 64340923
Miosis 68.81 9.78 118 154029 13148 64331437
Confusional state 68.18 9.78 937 153210 260207 64084378
Rheumatoid factor positive 67.37 9.78 4 154143 34934 64309651
Abnormal dreams 67.22 9.78 102 154045 10254 64334331
Parkinsonism 67.00 9.78 122 154025 14251 64330334
Insomnia 66.79 9.78 745 153402 197091 64147494
Alopecia 65.86 9.78 191 153956 165499 64179086
Impulsive behaviour 65.71 9.78 53 154094 2610 64341975
Bone marrow failure 65.19 9.78 17 154130 47935 64296650
Therapeutic product effect decreased 64.71 9.78 110 154037 115241 64229344
Helicobacter infection 64.19 9.78 8 154139 38354 64306231
Depressed level of consciousness 63.07 9.78 371 153776 81065 64263520
Product substitution issue 62.00 9.78 134 154013 17727 64326858
Cytomegalovirus infection 61.66 9.78 8 154139 37191 64307394
Memory impairment 61.06 9.78 382 153765 85300 64259285
Mental disorder 60.46 9.78 169 153978 26276 64318309
C-reactive protein increased 58.46 9.78 85 154062 94824 64249761
Disinhibition 58.25 9.78 46 154101 2197 64342388
Cardiac failure 57.56 9.78 146 154001 132227 64212358
Drug abuser 57.15 9.78 70 154077 5738 64338847
Lower respiratory tract infection 57.05 9.78 86 154061 94528 64250057
Product complaint 56.40 9.78 102 154045 11852 64332733
Antipsychotic drug level increased 55.85 9.78 65 154082 5050 64339535
Hallucination 54.69 9.78 329 153818 72459 64272126
Hostility 54.62 9.78 44 154103 2163 64342422
Hepatic function abnormal 53.47 9.78 45 154102 64268 64280317
Social avoidant behaviour 53.28 9.78 60 154087 4497 64340088
Haemoglobin decreased 52.77 9.78 263 153884 194800 64149785
Dyspnoea 52.71 9.78 1312 152835 717362 63627223
Bezoar 52.58 9.78 43 154104 2160 64342425
Myocardial depression 52.07 9.78 25 154122 478 64344107
Cough 51.78 9.78 467 153680 301681 64042904
Septic shock 51.71 9.78 109 154038 105328 64239257
Glossodynia 51.69 9.78 47 154100 64649 64279936
Blood creatinine increased 51.45 9.78 160 153987 135622 64208963
Cholecystitis chronic 51.34 9.78 85 154062 9202 64335383
Emotional distress 50.51 9.78 195 153952 35843 64308742
Hypersensitivity 50.26 9.78 270 153877 196182 64148403
Decorticate posture 49.52 9.78 21 154126 296 64344289
Victim of child abuse 49.47 9.78 29 154118 842 64343743
Libido increased 49.28 9.78 38 154109 1752 64342833
Blood prolactin increased 49.23 9.78 51 154096 3477 64341108
Abdominal discomfort 49.21 9.78 246 153901 182076 64162509
Mood altered 48.89 9.78 114 154033 15865 64328720
Dissociation 48.40 9.78 47 154100 2964 64341621
Apathy 48.18 9.78 92 154055 11140 64333445
Herpes zoster 47.71 9.78 72 154075 79115 64265470
Persistent genital arousal disorder 47.70 9.78 19 154128 226 64344359
Thinking abnormal 47.55 9.78 93 154054 11463 64333122
Oculogyric crisis 47.29 9.78 43 154104 2495 64342090
Erythema 46.81 9.78 259 153888 186811 64157774
Hyperprolactinaemia 46.64 9.78 53 154094 4012 64340573
Feeling abnormal 46.38 9.78 506 153641 133096 64211489
Nervousness 45.65 9.78 165 153982 29391 64315194
Pleural effusion 45.26 9.78 153 153994 126406 64218179
Hyperkalaemia 45.16 9.78 110 154037 101019 64243566
Sleep disorder due to general medical condition, insomnia type 45.14 9.78 5 154142 26265 64318320
Neuroleptic malignant syndrome 44.23 9.78 146 154001 24850 64319735
Neuropathy peripheral 44.16 9.78 139 154008 117386 64227199
Duodenal ulcer perforation 43.89 9.78 14 154133 34611 64309974
Discomfort 43.65 9.78 79 154068 80799 64263786
Parasomnia 43.49 9.78 22 154125 473 64344112
Drug level increased 43.10 9.78 179 153968 34017 64310568
Cerebral vasoconstriction 42.81 9.78 30 154117 1192 64343393
Long QT syndrome 42.78 9.78 57 154090 5082 64339503
C-reactive protein abnormal 42.05 9.78 9 154138 29038 64315547
Intentional product use issue 41.59 9.78 105 154042 95259 64249326
Migraine 41.30 9.78 274 153873 62403 64282182
Poor quality sleep 41.26 9.78 119 154028 18832 64325753
Blister 41.14 9.78 82 154065 80885 64263700
Synaesthesia 40.31 9.78 8 154139 0 64344585
Folliculitis 40.25 9.78 11 154136 30066 64314519
Blood hyposmosis 40.14 9.78 10 154137 18 64344567
Homicidal ideation 40.00 9.78 44 154103 3213 64341372
Alcoholism 39.97 9.78 45 154102 3372 64341213
Myelosuppression 39.80 9.78 5 154142 23825 64320760
Anorgasmia 39.69 9.78 26 154121 923 64343662
Impaired healing 39.40 9.78 52 154095 60421 64284164
Atrioventricular block first degree 38.95 9.78 82 154065 10652 64333933
Gastrointestinal disorder 38.94 9.78 99 154048 89610 64254975
Stress cardiomyopathy 38.70 9.78 75 154072 9182 64335403
Physical assault 38.64 9.78 31 154116 1515 64343070
Multiple sclerosis 38.44 9.78 116 154031 18825 64325760
Morbid thoughts 38.18 9.78 23 154124 703 64343882
White blood cell count decreased 38.14 9.78 221 153926 157616 64186969
Reduced facial expression 37.81 9.78 35 154112 2078 64342507
Neoplasm progression 37.45 9.78 26 154121 40938 64303647
Dependence 37.22 9.78 35 154112 2120 64342465
Mobility decreased 37.05 9.78 95 154052 85745 64258840
Product use issue 36.89 9.78 212 153935 151503 64193082
Eye movement disorder 36.75 9.78 63 154084 7016 64337569
Alcohol poisoning 36.66 9.78 48 154099 4207 64340378
Blood pressure fluctuation 36.53 9.78 42 154105 51829 64292756
Bruxism 36.18 9.78 44 154103 3580 64341005
Fear 35.85 9.78 118 154029 20053 64324532
Speech disorder 35.77 9.78 218 153929 48223 64296362
Amnesia 35.50 9.78 217 153930 48052 64296533
Libido decreased 35.21 9.78 50 154097 4734 64339851
Bipolar I disorder 34.96 9.78 31 154116 1740 64342845
Muscle injury 34.76 9.78 10 154137 26427 64318158
Affective disorder 34.74 9.78 59 154088 6521 64338064
Major depression 34.74 9.78 65 154082 7751 64336834
Blood lactate dehydrogenase increased 34.43 9.78 18 154129 33060 64311525
Pain 34.39 9.78 1034 153113 552477 63792108
Cogwheel rigidity 34.10 9.78 38 154109 2815 64341770
Flat affect 33.70 9.78 31 154116 1826 64342759
Obesity 33.65 9.78 117 154030 20445 64324140
Weight increased 33.44 9.78 705 153442 212643 64131942
Derealisation 33.22 9.78 28 154119 1467 64343118
Huntington's disease 33.01 9.78 8 154139 12 64344573
Traumatic coma 32.59 9.78 10 154137 50 64344535
Marital problem 32.41 9.78 14 154133 207 64344378
Ascites 32.18 9.78 62 154085 61939 64282646
Psychomotor hyperactivity 31.71 9.78 91 154056 14360 64330225
Increased appetite 31.71 9.78 73 154074 10073 64334512
Arthritis 31.57 9.78 99 154048 83715 64260870
Violence-related symptom 31.43 9.78 20 154127 675 64343910
Mental impairment 31.22 9.78 98 154049 16245 64328340
Bipolar disorder 31.02 9.78 57 154090 6704 64337881
Abnormal sleep-related event 30.93 9.78 21 154126 792 64343793
Hallucination, visual 30.72 9.78 140 154007 27694 64316891
Sinus bradycardia 30.56 9.78 122 154025 22771 64321814
Suspected suicide 30.12 9.78 65 154082 8589 64335996
Inappropriate antidiuretic hormone secretion 29.93 9.78 119 154028 22170 64322415
Soft tissue injury 29.91 9.78 27 154120 1552 64343033
Sinus tachycardia 29.84 9.78 154 153993 32034 64312551
Bradyphrenia 29.76 9.78 68 154079 9338 64335247
Drug hypersensitivity 29.73 9.78 395 153752 237420 64107165
Gastrointestinal haemorrhage 29.48 9.78 190 153957 132122 64212463
Sleep disorder 29.09 9.78 243 153904 59466 64285119
Delusion 29.05 9.78 102 154045 17912 64326673
Foetal exposure during pregnancy 28.93 9.78 44 154103 4432 64340153
Obsessive thoughts 28.90 9.78 22 154125 995 64343590
Oxygen saturation decreased 28.68 9.78 145 154002 107031 64237554
Staring 28.64 9.78 32 154115 2378 64342207
Multiple organ dysfunction syndrome 28.41 9.78 135 154012 101278 64243307
Visceral congestion 28.38 9.78 20 154127 802 64343783
Unresponsive to stimuli 28.34 9.78 212 153935 50181 64294404
Borderline personality disorder 28.33 9.78 20 154127 804 64343781
Social anxiety disorder 28.27 9.78 16 154131 434 64344151
Emotional disorder 28.26 9.78 80 154067 12527 64332058
Transplant rejection 28.23 9.78 4 154143 17397 64327188
Dysphoria 28.17 9.78 43 154104 4345 64340240
Panic reaction 28.05 9.78 41 154106 3986 64340599
Negative thoughts 27.89 9.78 24 154123 1294 64343291
Hypersomnia 27.88 9.78 107 154040 19610 64324975
Basilar migraine 27.83 9.78 9 154138 55 64344530
Blood bilirubin increased 27.79 9.78 60 154087 57493 64287092
Pulseless electrical activity 27.74 9.78 80 154067 12659 64331926
Hypomania 27.64 9.78 49 154098 5605 64338980
Therapeutic product effect incomplete 27.12 9.78 141 154006 103341 64241244
Depersonalisation/derealisation disorder 27.12 9.78 26 154121 1614 64342971
Loss of libido 27.00 9.78 31 154116 2373 64342212
Hyponatraemia 26.86 9.78 501 153646 147838 64196747
Palmar-plantar erythrodysaesthesia syndrome 26.73 9.78 18 154129 28801 64315784
Tension 26.61 9.78 39 154108 3801 64340784
Lethargy 26.60 9.78 278 153869 72316 64272269
Multiple sclerosis relapse 26.60 9.78 179 153968 40956 64303629
Carbon monoxide poisoning 26.59 9.78 13 154134 259 64344326
Dysphemia 26.59 9.78 35 154112 3084 64341501
Blunted affect 26.31 9.78 15 154132 413 64344172
Feeling guilty 26.06 9.78 19 154128 804 64343781
Aspergillus infection 26.03 9.78 4 154143 16375 64328210
Tachyphrenia 25.96 9.78 27 154120 1849 64342736
Influenza like illness 25.87 9.78 243 153904 61459 64283126
Neutrophil count decreased 25.81 9.78 96 154051 77100 64267485
Asphyxia 25.79 9.78 65 154082 9501 64335084
Antidepressant drug level increased 25.55 9.78 14 154133 356 64344229
Respiratory failure 25.49 9.78 254 153893 160929 64183656
Initial insomnia 25.46 9.78 48 154099 5756 64338829
Yawning 25.44 9.78 22 154125 1194 64343391
Antipsychotic drug level below therapeutic 25.15 9.78 20 154127 965 64343620
Catatonia 25.12 9.78 56 154091 7564 64337021
Injury 24.73 9.78 223 153924 55769 64288816
Bacteraemia 24.70 9.78 17 154130 26894 64317691
Rhabdomyolysis 24.65 9.78 331 153816 91395 64253190
Liver disorder 24.63 9.78 57 154090 53294 64291291
Thrombotic microangiopathy 24.44 9.78 5 154142 16650 64327935
Somnambulism 24.42 9.78 44 154103 5097 64339488
Ventricular hypokinesia 24.39 9.78 56 154091 7713 64336872
Tumour lysis syndrome 24.39 9.78 8 154139 19432 64325153
Coordination abnormal 24.36 9.78 85 154062 14879 64329706
Burning mouth syndrome 24.31 9.78 15 154132 479 64344106
Tachycardia 24.31 9.78 497 153650 149082 64195503
Self esteem decreased 24.23 9.78 19 154128 898 64343687
Posture abnormal 24.19 9.78 35 154112 3371 64341214
Heart sounds 23.96 9.78 16 154131 587 64343998
Heart rate 23.81 9.78 8 154139 56 64344529
Respiration abnormal 23.80 9.78 49 154098 6266 64338319
Ill-defined disorder 23.79 9.78 43 154104 44009 64300576
Serum serotonin decreased 23.67 9.78 6 154141 12 64344573
Sternal fracture 23.61 9.78 28 154119 2219 64342366
Treatment noncompliance 23.37 9.78 181 153966 43301 64301284
Decreased interest 23.10 9.78 34 154113 3326 64341259
Anterograde amnesia 23.09 9.78 16 154131 624 64343961
Disseminated intravascular coagulation 22.99 9.78 26 154121 32322 64312263
Protein C increased 22.98 9.78 9 154138 102 64344483
Dysarthria 22.96 9.78 230 153917 59176 64285409
Priapism 22.84 9.78 37 154110 3933 64340652
Haemophagocytic lymphohistiocytosis 22.53 9.78 7 154140 17602 64326983
Compulsive shopping 22.50 9.78 17 154130 760 64343825
Diet failure 22.49 9.78 7 154140 37 64344548
Osteonecrosis of jaw 22.30 9.78 38 154109 39787 64304798
Accidental overdose 22.28 9.78 147 154000 33410 64311175
Drug screen positive 22.24 9.78 45 154102 5684 64338901
Therapeutic response unexpected 22.21 9.78 90 154057 16911 64327674
Choreoathetosis 22.17 9.78 22 154125 1425 64343160
Pneumocystis jirovecii pneumonia 22.16 9.78 20 154127 27614 64316971
Depressive symptom 22.02 9.78 39 154108 4457 64340128
Bulimia nervosa 21.98 9.78 11 154136 231 64344354
Myocardial infarction 21.98 9.78 272 153875 165549 64179036
Personality disorder 21.97 9.78 40 154107 4671 64339914
Polyneuropathy 21.96 9.78 10 154137 19884 64324701
Trichotillomania 21.84 9.78 10 154137 171 64344414
Autonomic nervous system imbalance 21.75 9.78 37 154110 4095 64340490
Hyporesponsive to stimuli 21.59 9.78 24 154123 1773 64342812
Disorientation 21.50 9.78 216 153931 55612 64288973
Depression suicidal 21.45 9.78 28 154119 2447 64342138
Hypertonia 21.44 9.78 47 154100 6278 64338307
Oral discharge 21.23 9.78 11 154136 249 64344336
Chorea 21.14 9.78 25 154122 1975 64342610
Myelodysplastic syndrome 20.90 9.78 21 154126 27558 64317027
Haematotoxicity 20.83 9.78 3 154144 12893 64331692
Obsessive-compulsive symptom 20.72 9.78 9 154138 135 64344450
Inflammation 20.67 9.78 83 154064 65217 64279368
Sinusitis 20.63 9.78 236 153911 145692 64198893
Musculoskeletal pain 20.62 9.78 112 154035 81182 64263403
Graft versus host disease 20.57 9.78 4 154143 13809 64330776
Panic disorder 20.57 9.78 29 154118 2728 64341857
Sluggishness 20.21 9.78 43 154104 5627 64338958
Red blood cell sedimentation rate increased 20.20 9.78 27 154120 31208 64313377
Analgesic drug level increased 20.17 9.78 26 154121 2244 64342341
Agitation neonatal 20.16 9.78 4 154143 0 64344585
Cardiac failure congestive 20.13 9.78 207 153940 130373 64214212
Mast cell activation syndrome 20.09 9.78 12 154135 361 64344224
Pathogen resistance 20.07 9.78 3 154144 12540 64332045
Alcohol interaction 20.06 9.78 37 154110 4364 64340221
Dreamy state 20.03 9.78 7 154140 56 64344529
Ventricular fibrillation 19.97 9.78 111 154036 23749 64320836
Patent ductus arteriosus 19.95 9.78 8 154139 97 64344488
Exposure during pregnancy 19.93 9.78 278 153869 77397 64267188
Sleep-related eating disorder 19.92 9.78 15 154132 667 64343918
Phobia 19.77 9.78 12 154135 372 64344213
Ideas of reference 19.76 9.78 9 154138 152 64344433
Blood urea increased 19.72 9.78 48 154099 44105 64300480
Urinary incontinence 19.72 9.78 151 153996 36000 64308585
Cerebral infarction 19.64 9.78 43 154104 41001 64303584
Exposure via ingestion 19.62 9.78 39 154108 4863 64339722
Thought insertion 19.56 9.78 6 154141 30 64344555
Prolonged expiration 19.51 9.78 16 154131 807 64343778
Stress 19.51 9.78 226 153921 60308 64284277
Hallucinations, mixed 19.42 9.78 44 154103 6008 64338577
Cataplexy 19.37 9.78 16 154131 815 64343770
Economic problem 19.36 9.78 25 154122 2162 64342423
Delusion of grandeur 19.34 9.78 14 154133 586 64343999
Genital anaesthesia 19.10 9.78 5 154142 12 64344573
IIIrd nerve paresis 18.94 9.78 9 154138 168 64344417
Alcohol use 18.89 9.78 37 154110 4565 64340020
Drug eruption 18.87 9.78 36 154111 36100 64308485
Hospitalisation 18.86 9.78 104 154043 75103 64269482
Accommodation disorder 18.85 9.78 13 154134 503 64344082
Post-traumatic neck syndrome 18.84 9.78 23 154124 1879 64342706
Pulmonary haemosiderosis 18.82 9.78 5 154142 13 64344572
Renal failure 18.81 9.78 313 153834 181375 64163210
CYP3A4 polymorphism 18.65 9.78 7 154140 70 64344515
Epidural lipomatosis 18.62 9.78 16 154131 861 64343724
Induced abortion failed 18.29 9.78 9 154138 182 64344403
Agoraphobia 18.17 9.78 13 154134 534 64344051
Serum sickness-like reaction 18.11 9.78 13 154134 537 64344048
Interstitial lung disease 18.07 9.78 148 153999 97584 64247001
Heart rate decreased 18.07 9.78 69 154078 54998 64289587
Blood pressure diastolic decreased 18.05 9.78 16 154131 22285 64322300
Respiratory disorder 17.97 9.78 37 154110 36074 64308511
Posterior reversible encephalopathy syndrome 17.93 9.78 17 154130 22929 64321656
Hypoplastic left heart syndrome 17.92 9.78 4 154143 3 64344582
Peritonitis 17.90 9.78 20 154127 25003 64319582
Hypoalbuminaemia 17.84 9.78 10 154137 17664 64326921
Anaphylactic reaction 17.74 9.78 94 154053 68570 64276015
Product use in unapproved indication 17.72 9.78 306 153841 176312 64168273
Feeling drunk 17.71 9.78 34 154113 4133 64340452
Colitis 17.69 9.78 76 154071 58598 64285987
Feeling of despair 17.68 9.78 26 154121 2542 64342043
Bronchopulmonary aspergillosis 17.59 9.78 12 154135 19073 64325512
Asthenia 17.55 9.78 840 153307 427204 63917381
Blood pressure systolic increased 17.52 9.78 60 154087 49393 64295192
Prostate cancer 17.52 9.78 13 154134 19782 64324803
Narcolepsy 17.48 9.78 17 154130 1074 64343511
Metabolic acidosis 17.42 9.78 252 153895 70706 64273879
Retinal phototoxicity 17.39 9.78 4 154143 4 64344581
Neutropenic sepsis 17.32 9.78 18 154129 23254 64321331
Psychomotor retardation 17.18 9.78 38 154109 5105 64339480
Amenorrhoea 17.18 9.78 44 154103 6495 64338090
Pupil fixed 17.09 9.78 29 154118 3203 64341382
Serum ferritin abnormal 17.03 9.78 11 154136 381 64344204
Vision blurred 17.02 9.78 307 153840 90009 64254576
Chronic actinic dermatitis 17.00 9.78 5 154142 21 64344564
Liver function test increased 16.93 9.78 30 154117 30940 64313645
Pituitary tumour benign 16.93 9.78 24 154123 2269 64342316
Neonatal seizure 16.92 9.78 4 154143 5 64344580
Proteinuria 16.90 9.78 25 154122 27698 64316887
Gallbladder disorder 16.85 9.78 83 154064 16947 64327638
Tubulointerstitial nephritis 16.84 9.78 30 154117 30879 64313706
Enterocolitis 16.84 9.78 4 154143 12014 64332571
Pseudomonas infection 16.81 9.78 11 154136 17872 64326713
Cytokine release syndrome 16.79 9.78 15 154132 20814 64323771
Cellulitis 16.78 9.78 143 154004 93514 64251071
Complication of device insertion 16.71 9.78 37 154110 4975 64339610
Foetal arrhythmia 16.64 9.78 5 154142 23 64344562
Device placement issue 16.64 9.78 14 154133 732 64343853
Acute myeloid leukaemia 16.51 9.78 25 154122 27438 64317147
Tenosynovitis 16.46 9.78 4 154143 11829 64332756
Sexual dysfunction 16.44 9.78 43 154104 6428 64338157
Supraventricular tachyarrhythmia 16.30 9.78 7 154140 102 64344483
Dehydroepiandrosterone decreased 16.30 9.78 5 154142 25 64344560
Micturition urgency 16.14 9.78 58 154089 10301 64334284
Tinnitus 16.14 9.78 138 154009 33995 64310590
Oedema peripheral 16.12 9.78 381 153766 209936 64134649
Feeling jittery 16.11 9.78 59 154088 10576 64334009
Antisocial personality disorder 15.98 9.78 5 154142 27 64344558
Agranulocytosis 15.97 9.78 43 154104 38186 64306399
Oesophageal food impaction 15.86 9.78 10 154137 332 64344253
Disturbance in sexual arousal 15.86 9.78 8 154139 171 64344414
Productive cough 15.85 9.78 106 154041 73097 64271488
Hypercalcaemia 15.80 9.78 32 154115 31384 64313201
Gambling disorder 15.75 9.78 21 154126 1873 64342712
Oedema 15.75 9.78 142 154005 91793 64252792
Hypnopompic hallucination 15.73 9.78 6 154141 63 64344522
COVID-19 pneumonia 15.72 9.78 10 154137 16494 64328091
Sleep paralysis 15.70 9.78 12 154135 546 64344039
Binge eating 15.65 9.78 11 154136 439 64344146
Slow response to stimuli 15.62 9.78 19 154128 1546 64343039
Antisocial behaviour 15.60 9.78 12 154135 551 64344034
Jaundice neonatal 15.49 9.78 7 154140 116 64344469
Formication 15.48 9.78 33 154114 4324 64340261
Secondary hypogonadism 15.44 9.78 10 154137 348 64344237
Road traffic accident 15.44 9.78 126 154021 30619 64313966
Self-medication 15.43 9.78 32 154115 4113 64340472
Loss of consciousness 15.41 9.78 464 153683 147901 64196684
Cytopenia 15.26 9.78 9 154138 15462 64329123
Musculoskeletal stiffness 15.25 9.78 205 153942 123001 64221584
Drooling 15.24 9.78 37 154110 5282 64339303
Transaminases increased 15.20 9.78 55 154092 44539 64300046
Cholecystectomy 15.19 9.78 48 154099 7984 64336601
Fluid retention 15.18 9.78 82 154065 59524 64285061
Anhedonia 15.17 9.78 69 154078 13637 64330948
Spinal shock 15.13 9.78 5 154142 33 64344552
Chronic kidney disease 15.13 9.78 79 154068 57840 64286745
Tremor neonatal 15.12 9.78 3 154144 0 64344585
Parkinsonian gait 15.07 9.78 14 154133 835 64343750
Diverticulitis 14.98 9.78 45 154102 38573 64306012
Selective mutism 14.94 9.78 6 154141 73 64344512
Energy increased 14.92 9.78 25 154122 2733 64341852
Sudden onset of sleep 14.88 9.78 12 154135 591 64343994
Therapeutic product effect variable 14.88 9.78 19 154128 1625 64342960
Dermatillomania 14.87 9.78 8 154139 196 64344389
Fatigue 14.87 9.78 1565 152582 747165 63597420
Attention deficit hyperactivity disorder 14.84 9.78 25 154122 2745 64341840
Atrial septal defect 14.79 9.78 19 154128 1634 64342951
Rash maculo-papular 14.74 9.78 60 154087 46966 64297619
Hyperdynamic left ventricle 14.74 9.78 9 154138 282 64344303
Concussion 14.61 9.78 47 154100 7891 64336694
Death of relative 14.55 9.78 8 154139 205 64344380
Mental status changes 14.53 9.78 216 153931 60946 64283639
Blood pressure measurement 14.52 9.78 10 154137 386 64344199
Atrioventricular block second degree 14.51 9.78 41 154106 6413 64338172
Tourette's disorder 14.45 9.78 6 154141 80 64344505
Large intestine perforation 14.44 9.78 6 154141 12598 64331987
Cytomegalovirus viraemia 14.41 9.78 4 154143 10824 64333761
Cholangitis 14.36 9.78 4 154143 10798 64333787
Gastric bypass 14.33 9.78 15 154132 1035 64343550
Locked-in syndrome 14.32 9.78 12 154135 624 64343961
Breath sounds abnormal 14.30 9.78 5 154142 11664 64332921
Hip arthroplasty 14.28 9.78 18 154129 21333 64323252
COVID-19 14.27 9.78 94 154053 65046 64279539
Pregnancy on oral contraceptive 14.24 9.78 13 154134 758 64343827
Hypoprolactinaemia 14.17 9.78 4 154143 14 64344571
Salivary hypersecretion 14.17 9.78 62 154085 12051 64332534
Klebsiella infection 14.16 9.78 7 154140 13274 64331311
Haemorrhage intracranial 14.11 9.78 22 154125 23862 64320723
Constipation 14.04 9.78 429 153718 228908 64115677
Accidental exposure to product 14.00 9.78 26 154121 26338 64318247
Coma uraemic 13.99 9.78 5 154142 43 64344542
Thrombosis 13.98 9.78 105 154042 70537 64274048
Jaw clicking 13.96 9.78 4 154143 15 64344570
Eating disorder 13.94 9.78 78 154069 16727 64327858
Post 5-alpha-reductase inhibitor syndrome 13.87 9.78 6 154141 89 64344496
Tongue biting 13.86 9.78 19 154128 1741 64342844
Autism spectrum disorder 13.85 9.78 14 154133 927 64343658
Skin ulcer 13.85 9.78 56 154091 43918 64300667
Pruritus 13.81 9.78 608 153539 311792 64032793
Decreased appetite 13.80 9.78 541 153606 280748 64063837
Pneumothorax 13.77 9.78 23 154124 24275 64320310
Epistaxis 13.75 9.78 159 153988 97972 64246613
Pericardial effusion 13.66 9.78 48 154099 39206 64305379
Antidepressant drug level above therapeutic 13.65 9.78 11 154136 541 64344044
Breast discomfort 13.63 9.78 9 154138 324 64344261
Logorrhoea 13.57 9.78 30 154117 4029 64340556
Metastases to lung 13.54 9.78 10 154137 15254 64329331
Blood test abnormal 13.53 9.78 7 154140 12936 64331649
Alcohol withdrawal syndrome 13.50 9.78 19 154128 1784 64342801
Diffuse large B-cell lymphoma 13.47 9.78 4 154143 10357 64334228
Bradycardia 13.45 9.78 374 153773 117845 64226740
Cold agglutinins positive 13.41 9.78 5 154142 49 64344536
Prolonged rupture of membranes 13.33 9.78 5 154142 50 64344535
Personality change 13.29 9.78 48 154099 8545 64336040
Electrolyte depletion 13.24 9.78 9 154138 340 64344245
Chemical burn 13.24 9.78 10 154137 447 64344138
Confabulation 13.20 9.78 10 154137 449 64344136
Renal disorder 13.15 9.78 42 154105 35323 64309262
Mutism 13.15 9.78 20 154127 2014 64342571
Device related infection 13.13 9.78 34 154113 30592 64313993
Haemolysis 13.07 9.78 5 154142 11034 64333551
Gestational diabetes 13.05 9.78 36 154111 5554 64339031
Faecal calprotectin 13.04 9.78 4 154143 20 64344565
Umbilical cord around neck 13.04 9.78 4 154143 20 64344565
Urinary retention 12.99 9.78 177 153970 49024 64295561
Joint hyperextension 12.90 9.78 8 154139 258 64344327
Prescribed overdose 12.86 9.78 88 154059 20243 64324342
Ventricular arrhythmia 12.84 9.78 43 154104 7372 64337213
Purple glove syndrome 12.79 9.78 8 154139 262 64344323
Venoocclusive liver disease 12.78 9.78 4 154143 10011 64334574
Blood creatine phosphokinase MB 12.72 9.78 4 154143 22 64344563
Balance disorder 12.70 9.78 276 153871 83650 64260935
Therapy change 12.68 9.78 39 154108 6395 64338190
Nystagmus 12.65 9.78 49 154098 9019 64335566
Basal cell carcinoma 12.64 9.78 35 154112 30803 64313782
Candida infection 12.63 9.78 36 154111 31383 64313202
Vascular stenosis 12.62 9.78 10 154137 480 64344105
Dissociative identity disorder 12.59 9.78 5 154142 59 64344526
Dyspnoea exertional 12.58 9.78 114 154033 73616 64270969
Appetite disorder 12.58 9.78 39 154108 6422 64338163
Haemorrhage 12.55 9.78 125 154022 79226 64265359
Body temperature decreased 12.54 9.78 27 154120 25901 64318684
Hypervolaemia 12.54 9.78 48 154099 38237 64306348
Blood magnesium decreased 12.52 9.78 66 154081 13839 64330746
Muscle necrosis 12.46 9.78 15 154132 1208 64343377
Second primary malignancy 12.42 9.78 7 154140 12330 64332255
Enterococcal infection 12.41 9.78 9 154138 13857 64330728
Multiple system atrophy 12.40 9.78 9 154138 378 64344207
Lumbar radiculopathy 12.40 9.78 18 154129 1739 64342846
Ventricular hypertrophy 12.38 9.78 39 154108 6477 64338108
Back pain 12.30 9.78 481 153666 249690 64094895
Impulse-control disorder 12.29 9.78 17 154130 1571 64343014
Vasoplegia syndrome 12.28 9.78 23 154124 2744 64341841
Brugada syndrome 12.27 9.78 14 154133 1064 64343521
Resting tremor 12.26 9.78 16 154131 1398 64343187
Procedural hypertension 12.24 9.78 8 154139 283 64344302
Dehydration 12.18 9.78 410 153737 216353 64128232
Blood triglycerides increased 12.14 9.78 82 154065 18784 64325801
Toxic skin eruption 12.14 9.78 17 154130 19267 64325318
Prostatic specific antigen increased 12.11 9.78 3 154144 8757 64335828
Red blood cell count decreased 12.08 9.78 67 154080 48319 64296266
Affect lability 12.07 9.78 48 154099 8942 64335643
Haematochezia 12.04 9.78 101 154046 66272 64278313
Enthesopathy 12.03 9.78 4 154143 9634 64334951
Plasma cell mastitis 12.03 9.78 4 154143 27 64344558
Blood pressure increased 12.03 9.78 317 153830 172235 64172350
Persecutory delusion 12.00 9.78 29 154118 4129 64340456
End stage renal disease 11.98 9.78 5 154142 10470 64334115
Coagulation factor VII level decreased 11.98 9.78 7 154140 202 64344383
Appendicitis perforated 11.97 9.78 23 154124 2797 64341788
Hypoxic-ischaemic encephalopathy 11.97 9.78 41 154106 7111 64337474
Compulsive hoarding 11.95 9.78 5 154142 68 64344517
Skin infection 11.92 9.78 11 154136 15026 64329559
Metastases to bone 11.90 9.78 19 154128 20416 64324169
Agonal rhythm 11.89 9.78 5 154142 69 64344516
Acquired cardiac septal defect 11.84 9.78 3 154144 6 64344579
Apgar score low 11.84 9.78 3 154144 6 64344579
Right aortic arch 11.84 9.78 3 154144 6 64344579
Loss of bladder sensation 11.82 9.78 5 154142 70 64344515
Vaginal haemorrhage 11.81 9.78 83 154064 19261 64325324
Food interaction 11.81 9.78 16 154131 1450 64343135
Blood potassium decreased 11.78 9.78 148 153999 40251 64304334
Skin cancer 11.76 9.78 7 154140 11967 64332618
Dissociative disorder 11.73 9.78 9 154138 412 64344173
Cataract 11.72 9.78 73 154074 51189 64293396
Hypogammaglobulinaemia 11.65 9.78 5 154142 10294 64334291
Osteonecrosis 11.60 9.78 32 154115 28197 64316388
Knee arthroplasty 11.55 9.78 30 154117 26969 64317616
Duodenal ulcer repair 11.51 9.78 5 154142 75 64344510
Drug resistance 11.50 9.78 44 154103 35058 64309527
Dizziness 11.49 9.78 1185 152962 428978 63915607
Intervertebral disc displacement 11.48 9.78 9 154138 425 64344160
Gout 11.47 9.78 21 154126 21392 64323193
Stereotypy 11.44 9.78 12 154135 830 64343755
Cholinergic syndrome 11.43 9.78 12 154135 831 64343754
Plasma cell myeloma 11.39 9.78 64 154083 46011 64298574
Pain in extremity 11.39 9.78 600 153547 302485 64042100
Grandiosity 11.37 9.78 10 154137 555 64344030
Full blood count decreased 11.36 9.78 23 154124 22559 64322026
Drug-induced liver injury 11.34 9.78 67 154080 47576 64297009
Placenta praevia 11.31 9.78 11 154136 695 64343890
Metastases to central nervous system 11.24 9.78 10 154137 13902 64330683
Hypnagogic hallucination 11.23 9.78 6 154141 145 64344440
Neonatal respiratory distress syndrome 11.17 9.78 7 154140 230 64344355
Renal artery thrombosis 11.14 9.78 9 154138 444 64344141
Chronic fatigue syndrome 11.11 9.78 14 154133 1181 64343404
Psychotic behaviour 11.11 9.78 13 154134 1016 64343569
Gaze palsy 11.08 9.78 21 154126 2529 64342056
Pulmonary vasculitis 11.06 9.78 7 154140 234 64344351
Compulsions 10.98 9.78 8 154139 338 64344247
Medical diet 10.98 9.78 3 154144 9 64344576
Cerebrovascular stenosis 10.97 9.78 6 154141 152 64344433
Pulmonary valve stenosis 10.94 9.78 4 154143 37 64344548
Creatinine renal clearance decreased 10.90 9.78 11 154136 14410 64330175
Hyperthermia 10.86 9.78 69 154078 15481 64329104
Hypothermia 10.86 9.78 83 154064 19773 64324812
Exposure via inhalation 10.84 9.78 5 154142 87 64344498
Status migrainosus 10.84 9.78 4 154143 38 64344547
Blood pressure decreased 10.82 9.78 143 154004 86056 64258529
Withdrawal catatonia 10.80 9.78 6 154141 157 64344428
Schizophrenia 10.75 9.78 54 154093 11114 64333471
Hyperinsulinism 10.74 9.78 3 154144 10 64344575
Premature baby 10.73 9.78 24 154123 3248 64341337
Loss of personal independence in daily activities 10.70 9.78 116 154031 72338 64272247
Peripheral sensory neuropathy 10.70 9.78 7 154140 11371 64333214
Alpha 1 globulin increased 10.69 9.78 5 154142 90 64344495
Acute psychosis 10.65 9.78 26 154121 3726 64340859
Hepatic failure 10.64 9.78 83 154064 55311 64289274
Maternal drugs affecting foetus 10.58 9.78 16 154131 1604 64342981
Intrusive thoughts 10.56 9.78 8 154139 359 64344226
Oral candidiasis 10.55 9.78 25 154122 23187 64321398
Panniculitis 10.55 9.78 4 154143 8875 64335710
Haematuria 10.53 9.78 93 154054 60378 64284207
Head deformity 10.49 9.78 4 154143 42 64344543
Febrile bone marrow aplasia 10.48 9.78 7 154140 11248 64333337
Transient aphasia 10.46 9.78 6 154141 167 64344418
Blood cholesterol increased 10.45 9.78 173 153974 49893 64294692
Legal problem 10.43 9.78 6 154141 168 64344417
Localised infection 10.41 9.78 37 154110 30124 64314461
Eye colour change 10.39 9.78 8 154139 368 64344217
Hypertriglyceridaemia 10.39 9.78 7 154140 11198 64333387
Gastrointestinal hypermotility 10.38 9.78 7 154140 261 64344324
Lymphocyte count decreased 10.36 9.78 56 154091 40643 64303942
Lymphatic system neoplasm 10.32 9.78 4 154143 44 64344541
Melanocytic hyperplasia 10.32 9.78 3 154144 12 64344573
Cardiomegaly 10.29 9.78 94 154053 23590 64320995
Spasmodic dysphonia 10.27 9.78 6 154141 173 64344412
Food allergy 10.26 9.78 3 154144 7848 64336737
Squamous cell carcinoma of skin 10.25 9.78 8 154139 11868 64332717
Ventricular tachycardia 10.19 9.78 126 154021 34139 64310446
Anorexia nervosa 10.15 9.78 6 154141 177 64344408
Sleep attacks 10.12 9.78 6 154141 178 64344407
Osteoporosis 10.11 9.78 59 154088 42021 64302564
Toxic epidermal necrolysis 10.10 9.78 50 154097 37116 64307469
Aplastic anaemia 10.10 9.78 11 154136 13909 64330676
Brucellosis 9.99 9.78 5 154142 105 64344480
Heavy menstrual bleeding 9.98 9.78 56 154091 12021 64332564
Gastric disorder 9.96 9.78 36 154111 29161 64315424
Regurgitation 9.95 9.78 18 154129 2091 64342494
Full blood count abnormal 9.95 9.78 37 154110 29720 64314865
Bradypnoea 9.91 9.78 31 154116 5128 64339457
Internal haemorrhage 9.90 9.78 3 154144 7664 64336921
Right ventricular failure 9.86 9.78 23 154124 21448 64323137
Blood glucose fluctuation 9.84 9.78 34 154113 5921 64338664
Breast enlargement 9.84 9.78 14 154133 1328 64343257
Imprisonment 9.80 9.78 9 154138 529 64344056
Strabismus 9.78 9.78 18 154129 2119 64342466

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Feeling jittery 44.99 21.75 18 757 44 83859
Exposure during pregnancy 31.08 21.75 48 727 1275 82628
Hypertonia neonatal 27.16 21.75 23 752 304 83599
Tremor neonatal 23.52 21.75 13 762 79 83824

Pharmacologic Action:

SourceCodeDescription
ATC N06AB03 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
ATC N06CA03 NERVOUS SYSTEM
PSYCHOANALEPTICS
PSYCHOLEPTICS AND PSYCHOANALEPTICS IN COMBINATION
Antidepressants in combination with psycholeptics
FDA MoA N0000000109 Serotonin Uptake Inhibitors
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:50949 SSRI
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:88188 allergenic drug
MeSH PA D000928 Antidepressive Agents
MeSH PA D018687 Antidepressive Agents, Second-Generation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D065690 Cytochrome P-450 CYP2D6 Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D017367 Serotonin Uptake Inhibitors
FDA EPC N0000175696 Serotonin Reuptake Inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Premenstrual dysphoric disorder indication 596004
Depressive disorder indication 35489007
Bulimia nervosa indication 78004001
Bipolar affective disorder, current episode depression indication 191627008 DOID:3312
Obsessive-compulsive disorder indication 191736004 DOID:10933
Major depressive disorder indication 370143000
Panic disorder indication 371631005 DOID:594
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Postpartum depression off-label use 58703003 DOID:9478
Cataplexy and narcolepsy off-label use 193042000
Menopausal flushing off-label use 198436008
Fibromyalgia off-label use 203082005 DOID:631
Seasonal affective disorder off-label use 247803002
Suicidal thoughts contraindication 6471006
Weight gain finding contraindication 8943002
Sinus tachycardia contraindication 11092001
Hypercholesterolemia contraindication 13644009
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Cirrhosis of liver contraindication 19943007 DOID:5082
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Dehydration contraindication 34095006
Upper gastrointestinal hemorrhage contraindication 37372002
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Paralytic ileus contraindication 55525008 DOID:8442
Hyperlipidemia contraindication 55822004 DOID:1168
Anorexia nervosa contraindication 56882008 DOID:8689
Abnormal sexual function contraindication 56925008
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Heart failure contraindication 84114007 DOID:6000
Epilepsy contraindication 84757009 DOID:1826
Leukopenia contraindication 84828003 DOID:615
Hyponatremia contraindication 89627008
Tardive dyskinesia contraindication 102449007
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Cerebrovascular accident contraindication 230690007
Mania contraindication 231494001
Hypomania contraindication 231496004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Transient ischemic attack contraindication 266257000 DOID:224
Esophageal dysmotility contraindication 266434009 DOID:9192
Benign prostatic hyperplasia contraindication 266569009
Hypertriglyceridemia contraindication 302870006
Neutropenic disorder contraindication 303011007 DOID:1227
Serotonin syndrome contraindication 371089000
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Dogs Separation anxiety Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Reconcile Pegasus Laboratories Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.32 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 9.09 WOMBAT-PK CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 8.20 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 6.07 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.16 WOMBAT-PK
Sodium-dependent noradrenaline transporter Transporter Kd 6.62 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR Ki 6.61 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR ANTAGONIST Ki 5.30 IUPHAR
5-hydroxytryptamine receptor 2C GPCR Ki 6.40 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 6.11 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 5.70 PDSP
Alpha-2B adrenergic receptor GPCR Ki 6.16 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 5.70 WOMBAT-PK
Histamine H1 receptor GPCR Ki 5.96 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 6.05 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 5.57 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 6 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR Ki 5.54 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 5.57 PDSP
Sodium-dependent dopamine transporter Transporter Kd 5.44 WOMBAT-PK
Cytochrome P450 2D6 Enzyme IC50 6.16 DRUG MATRIX
Acetylcholinesterase Enzyme IC50 6.89 CHEMBL
Potassium channel subfamily K member 2 Ion channel IC50 4.85 CHEMBL
Histamine H3 receptor GPCR Ki 5.14 CHEMBL
Equilibrative nucleoside transporter 4 Transporter INHIBITOR Ki 4.64 IUPHAR
Beta-1 adrenergic receptor GPCR Ki 5.36 WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 8.70 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 6.11 CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 6.50 IUPHAR
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.62 CHEMBL
Transporter Transporter Ki 6.84 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 7.97 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 7.07 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 6.96 CHEMBL
5-hydroxytryptamine receptor 6 GPCR ANTAGONIST Ki 5.80 IUPHAR
Transporter Transporter Ki 6.80 CHEMBL
Serotonin 1 (5-HT1) receptor GPCR IC50 7.82 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 5.72 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 6.22 CHEMBL
Potassium voltage-gated channel subfamily C member 1 Ion channel IC50 4.88 CHEMBL
G protein-activated inward rectifier potassium channel 2 Ion channel GATING INHIBITOR IC50 4.80 IUPHAR
Sigma intracellular receptor 2 Unclassified Ki 4.79 CHEMBL

External reference:

IDSource
D00326 KEGG_DRUG
56296-78-7 SECONDARY_CAS_RN
4019389 VANDF
4019761 VANDF
C0016365 UMLSCUI
CHEBI:5118 CHEBI
RFX PDB_CHEM_ID
CHEMBL1201082 ChEMBL_ID
CHEMBL153036 ChEMBL_ID
CHEMBL41 ChEMBL_ID
DB00472 DRUGBANK_ID
D005473 MESH_DESCRIPTOR_UI
3386 PUBCHEM_CID
203 IUPHAR_LIGAND_ID
3883 INN_ID
01K63SUP8D UNII
227224 RXNORM
17711 MMSL
37675 MMSL
4091 MMSL
41730 MMSL
4746 MMSL
d00236 MMSL
001514 NDDF
004613 NDDF
372767007 SNOMEDCT_US
53640004 SNOMEDCT_US
75115009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3230 CAPSULE 25 mg ORAL NDA 34 sections
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3231 CAPSULE 25 mg ORAL NDA 34 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-0807 TABLET, FILM COATED 20 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-0807 TABLET, FILM COATED 20 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5262 TABLET, FILM COATED 60 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5262 TABLET, FILM COATED 60 mg ORAL ANDA 32 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5503 CAPSULE 25 mg ORAL ANDA 32 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5504 CAPSULE 25 mg ORAL ANDA 32 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5505 CAPSULE 50 mg ORAL ANDA 32 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5506 CAPSULE 25 mg ORAL ANDA 32 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5507 CAPSULE 50 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7188 TABLET, FILM COATED 10 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7188 TABLET, FILM COATED 10 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7198 CAPSULE 40 mg ORAL ANDA 31 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7198 CAPSULE 40 mg ORAL ANDA 31 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0121-0721 SOLUTION 20 mg ORAL ANDA 33 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0121-0721 SOLUTION 20 mg ORAL ANDA 33 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0121-4721 SOLUTION 20 mg ORAL ANDA 33 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0121-4721 SOLUTION 20 mg ORAL ANDA 33 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-1384 CAPSULE 10 mg ORAL ANDA 33 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-7625 CAPSULE 20 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-7638 CAPSULE 10 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8093 CAPSULE 10 mg ORAL ANDA 32 sections
Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8183 CAPSULE 40 mg ORAL ANDA 33 sections
Prozac HUMAN PRESCRIPTION DRUG LABEL 1 0777-3104 CAPSULE 10 mg ORAL NDA 35 sections
Prozac HUMAN PRESCRIPTION DRUG LABEL 1 0777-3105 CAPSULE 20 mg ORAL NDA 35 sections
Prozac HUMAN PRESCRIPTION DRUG LABEL 1 0777-3107 CAPSULE 40 mg ORAL NDA 35 sections
Fluoxetine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-2822 CAPSULE 20 mg ORAL ANDA 31 sections
Fluoxetine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-2823 CAPSULE 10 mg ORAL ANDA 31 sections
Fluoxetine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-2824 CAPSULE 40 mg ORAL ANDA 31 sections