Stem definition | Drug id | CAS RN |
---|---|---|
1053 | 128196-01-0 |
Dose | Unit | Route |
---|---|---|
10 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 8 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.88 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 14, 2002 | FDA | FOREST LABS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Suicide attempt | 472.04 | 9.51 | 674 | 151096 | 51058 | 50402296 |
Suicidal ideation | 463.91 | 9.51 | 693 | 151077 | 54692 | 50398662 |
Electrocardiogram QT prolonged | 447.18 | 9.51 | 658 | 151112 | 51228 | 50402126 |
Intentional overdose | 444.07 | 9.51 | 725 | 151045 | 61779 | 50391575 |
Serotonin syndrome | 370.95 | 9.51 | 413 | 151357 | 24300 | 50429054 |
Pemphigus | 338.81 | 9.51 | 4 | 151766 | 120162 | 50333192 |
Sopor | 317.05 | 9.51 | 343 | 151427 | 19536 | 50433818 |
Anxiety | 279.13 | 9.51 | 1163 | 150607 | 176443 | 50276911 |
Contraindicated product administered | 277.04 | 9.51 | 55 | 151715 | 148903 | 50304451 |
Systemic lupus erythematosus | 274.28 | 9.51 | 46 | 151724 | 140576 | 50312778 |
Synovitis | 266.38 | 9.51 | 30 | 151740 | 123835 | 50329519 |
Completed suicide | 256.43 | 9.51 | 924 | 150846 | 130965 | 50322389 |
Hand deformity | 250.14 | 9.51 | 12 | 151758 | 100187 | 50353167 |
Drug interaction | 246.30 | 9.51 | 1217 | 150553 | 198404 | 50254950 |
Overdose | 242.03 | 9.51 | 753 | 151017 | 98974 | 50354380 |
Depression | 238.89 | 9.51 | 1056 | 150714 | 164367 | 50288987 |
Somnolence | 231.88 | 9.51 | 1000 | 150770 | 153985 | 50299369 |
Treatment failure | 228.03 | 9.51 | 65 | 151705 | 137572 | 50315782 |
Arthropathy | 224.84 | 9.51 | 96 | 151674 | 157810 | 50295544 |
Glossodynia | 218.39 | 9.51 | 41 | 151729 | 115528 | 50337826 |
Joint swelling | 211.24 | 9.51 | 255 | 151515 | 245031 | 50208323 |
Drug intolerance | 201.44 | 9.51 | 216 | 151554 | 218888 | 50234466 |
Drug ineffective | 182.07 | 9.51 | 1580 | 150190 | 817753 | 49635601 |
Swelling | 174.82 | 9.51 | 207 | 151563 | 200665 | 50252689 |
Tremor | 166.09 | 9.51 | 734 | 151036 | 114169 | 50339185 |
Intentional self-injury | 163.87 | 9.51 | 268 | 151502 | 22844 | 50430510 |
Alopecia | 159.67 | 9.51 | 308 | 151462 | 244739 | 50208615 |
Infusion related reaction | 155.95 | 9.51 | 167 | 151603 | 169390 | 50283964 |
Product substitution issue | 153.62 | 9.51 | 200 | 151570 | 13857 | 50439497 |
Wound | 152.65 | 9.51 | 63 | 151707 | 105731 | 50347623 |
Hyponatraemia | 146.46 | 9.51 | 624 | 151146 | 95515 | 50357839 |
Pericarditis | 146.34 | 9.51 | 29 | 151741 | 78660 | 50374694 |
Rheumatoid arthritis | 135.04 | 9.51 | 251 | 151519 | 202299 | 50251055 |
Rheumatoid factor positive | 134.88 | 9.51 | 3 | 151767 | 49856 | 50403498 |
Coma | 131.94 | 9.51 | 423 | 151347 | 56456 | 50396898 |
Agitation | 127.47 | 9.51 | 401 | 151369 | 52983 | 50400371 |
Inappropriate antidiuretic hormone secretion | 125.33 | 9.51 | 175 | 151595 | 12968 | 50440386 |
Duodenal ulcer perforation | 122.39 | 9.51 | 3 | 151767 | 45608 | 50407746 |
Helicobacter infection | 120.72 | 9.51 | 7 | 151763 | 49695 | 50403659 |
Akathisia | 115.74 | 9.51 | 133 | 151637 | 8096 | 50445258 |
Abdominal discomfort | 110.75 | 9.51 | 342 | 151428 | 231299 | 50222055 |
Lower respiratory tract infection | 110.40 | 9.51 | 75 | 151695 | 95126 | 50358228 |
Therapeutic product effect decreased | 103.21 | 9.51 | 155 | 151615 | 135895 | 50317459 |
Tardive dyskinesia | 101.29 | 9.51 | 117 | 151653 | 7162 | 50446192 |
Peripheral swelling | 99.89 | 9.51 | 302 | 151468 | 205634 | 50247720 |
Seizure | 97.86 | 9.51 | 647 | 151123 | 117227 | 50336127 |
Arthralgia | 97.29 | 9.51 | 845 | 150925 | 437857 | 50015497 |
Mania | 96.21 | 9.51 | 140 | 151630 | 10776 | 50442578 |
Withdrawal syndrome | 96.19 | 9.51 | 182 | 151588 | 17408 | 50435946 |
Hepatic enzyme increased | 92.61 | 9.51 | 169 | 151601 | 137211 | 50316143 |
Rash | 92.02 | 9.51 | 854 | 150916 | 436617 | 50016737 |
Fall | 91.53 | 9.51 | 1461 | 150309 | 333471 | 50119883 |
Maternal exposure during pregnancy | 90.51 | 9.51 | 217 | 151553 | 159561 | 50293793 |
Poisoning deliberate | 88.68 | 9.51 | 114 | 151656 | 7798 | 50445556 |
Drug hypersensitivity | 88.67 | 9.51 | 419 | 151351 | 250591 | 50202763 |
Folliculitis | 88.17 | 9.51 | 8 | 151762 | 39217 | 50414137 |
Muscle injury | 87.81 | 9.51 | 6 | 151764 | 37105 | 50416249 |
Hypersensitivity | 86.46 | 9.51 | 342 | 151428 | 214819 | 50238535 |
Panic attack | 86.46 | 9.51 | 184 | 151586 | 19158 | 50434196 |
Irritability | 85.58 | 9.51 | 232 | 151538 | 28194 | 50425160 |
Torsade de pointes | 82.21 | 9.51 | 136 | 151634 | 11699 | 50441655 |
Impaired healing | 80.87 | 9.51 | 55 | 151715 | 69731 | 50383623 |
Discomfort | 80.72 | 9.51 | 125 | 151645 | 108255 | 50345099 |
Muscle rigidity | 79.38 | 9.51 | 121 | 151649 | 9708 | 50443646 |
Dyskinesia | 77.57 | 9.51 | 221 | 151549 | 27640 | 50425714 |
Drug abuse | 75.82 | 9.51 | 368 | 151402 | 59478 | 50393876 |
Sympathomimetic effect | 75.07 | 9.51 | 20 | 151750 | 38 | 50453316 |
Infection | 72.62 | 9.51 | 270 | 151500 | 172684 | 50280670 |
Stomatitis | 72.53 | 9.51 | 120 | 151650 | 101224 | 50352130 |
Disturbance in attention | 72.36 | 9.51 | 232 | 151538 | 30954 | 50422400 |
Crying | 72.16 | 9.51 | 177 | 151593 | 20239 | 50433115 |
Loss of consciousness | 69.90 | 9.51 | 544 | 151226 | 103809 | 50349545 |
Mental disorder | 68.74 | 9.51 | 182 | 151588 | 21809 | 50431545 |
Insomnia | 68.14 | 9.51 | 813 | 150957 | 174052 | 50279302 |
Mydriasis | 67.05 | 9.51 | 117 | 151653 | 10510 | 50442844 |
Tonsillar ulcer | 66.54 | 9.51 | 27 | 151743 | 264 | 50453090 |
Long QT syndrome | 65.33 | 9.51 | 61 | 151709 | 2906 | 50450448 |
Psychotic disorder | 64.64 | 9.51 | 177 | 151593 | 21635 | 50431719 |
C-reactive protein abnormal | 64.35 | 9.51 | 5 | 151765 | 27804 | 50425550 |
Extrapyramidal disorder | 63.39 | 9.51 | 121 | 151649 | 11649 | 50441705 |
Febrile neutropenia | 63.28 | 9.51 | 123 | 151647 | 97544 | 50355810 |
Paranoia | 62.80 | 9.51 | 112 | 151658 | 10236 | 50443118 |
Blister | 62.19 | 9.51 | 100 | 151670 | 85318 | 50368036 |
Neuroleptic malignant syndrome | 61.90 | 9.51 | 116 | 151654 | 11014 | 50442340 |
Restlessness | 61.82 | 9.51 | 191 | 151579 | 24982 | 50428372 |
Stiff person syndrome | 61.78 | 9.51 | 24 | 151746 | 207 | 50453147 |
Hyperhidrosis | 60.33 | 9.51 | 467 | 151303 | 88959 | 50364395 |
Product use issue | 59.74 | 9.51 | 238 | 151532 | 149237 | 50304117 |
Sepsis | 58.78 | 9.51 | 203 | 151567 | 132722 | 50320632 |
Pain | 58.67 | 9.51 | 1307 | 150463 | 577596 | 49875758 |
Death | 58.07 | 9.51 | 660 | 151110 | 324719 | 50128635 |
Toxicity to various agents | 57.56 | 9.51 | 926 | 150844 | 211573 | 50241781 |
Hallucination, auditory | 57.42 | 9.51 | 110 | 151660 | 10618 | 50442736 |
Pregnancy | 57.16 | 9.51 | 207 | 151563 | 29370 | 50423984 |
Galactorrhoea | 55.46 | 9.51 | 62 | 151708 | 3661 | 50449693 |
Cholecystitis chronic | 55.31 | 9.51 | 102 | 151668 | 9567 | 50443787 |
Dizziness | 55.21 | 9.51 | 1394 | 150376 | 344975 | 50108379 |
Drug withdrawal syndrome neonatal | 54.94 | 9.51 | 45 | 151725 | 1796 | 50451558 |
Emotional distress | 54.89 | 9.51 | 200 | 151570 | 28463 | 50424891 |
Confusional state | 54.45 | 9.51 | 821 | 150949 | 185107 | 50268247 |
Depressed mood | 54.22 | 9.51 | 224 | 151546 | 33799 | 50419555 |
Off label use | 53.64 | 9.51 | 1052 | 150718 | 473374 | 49979980 |
Apathy | 52.78 | 9.51 | 87 | 151683 | 7461 | 50445893 |
Depressed level of consciousness | 52.42 | 9.51 | 300 | 151470 | 51653 | 50401701 |
Lower respiratory tract infection viral | 50.55 | 9.51 | 29 | 151741 | 638 | 50452716 |
Hypertonia | 50.54 | 9.51 | 61 | 151709 | 3912 | 50449442 |
C-reactive protein increased | 50.12 | 9.51 | 76 | 151694 | 66398 | 50386956 |
Hyperreflexia | 48.57 | 9.51 | 68 | 151702 | 5050 | 50448304 |
Multiple sclerosis relapse | 47.97 | 9.51 | 255 | 151515 | 42709 | 50410645 |
Suicidal behaviour | 47.61 | 9.51 | 46 | 151724 | 2288 | 50451066 |
Oculogyric crisis | 46.87 | 9.51 | 37 | 151733 | 1400 | 50451954 |
Amnesia | 46.62 | 9.51 | 250 | 151520 | 42010 | 50411344 |
Electrocardiogram QRS complex prolonged | 46.31 | 9.51 | 68 | 151702 | 5276 | 50448078 |
Miosis | 45.84 | 9.51 | 74 | 151696 | 6236 | 50447118 |
Delusion | 45.46 | 9.51 | 99 | 151671 | 10470 | 50442884 |
Mobility decreased | 44.90 | 9.51 | 109 | 151661 | 79839 | 50373515 |
Feeling abnormal | 44.76 | 9.51 | 574 | 151196 | 124918 | 50328436 |
Psychomotor hyperactivity | 43.33 | 9.51 | 90 | 151680 | 9211 | 50444143 |
Bruxism | 42.52 | 9.51 | 49 | 151721 | 2991 | 50450363 |
Hip arthroplasty | 42.46 | 9.51 | 19 | 151751 | 30410 | 50422944 |
Pulmonary embolism | 42.30 | 9.51 | 479 | 151291 | 101225 | 50352129 |
Foetal exposure during pregnancy | 41.93 | 9.51 | 178 | 151592 | 27181 | 50426173 |
Hallucination | 41.68 | 9.51 | 261 | 151509 | 46396 | 50406958 |
Congenital absence of vertebra | 41.22 | 9.51 | 12 | 151758 | 36 | 50453318 |
Sinus bradycardia | 41.09 | 9.51 | 109 | 151661 | 13074 | 50440280 |
Inflammation | 41.07 | 9.51 | 67 | 151703 | 56845 | 50396509 |
Drug withdrawal syndrome | 40.65 | 9.51 | 166 | 151604 | 24915 | 50428439 |
Irritable bowel syndrome | 40.55 | 9.51 | 57 | 151713 | 51384 | 50401970 |
Aggression | 40.14 | 9.51 | 147 | 151623 | 20969 | 50432385 |
Abnormal behaviour | 40.06 | 9.51 | 140 | 151630 | 19518 | 50433836 |
Deep vein thrombosis | 39.96 | 9.51 | 365 | 151405 | 72939 | 50380415 |
Lip ulceration | 39.53 | 9.51 | 37 | 151733 | 1768 | 50451586 |
Pyrexia | 39.37 | 9.51 | 855 | 150915 | 379348 | 50074006 |
Reversible airways obstruction | 39.29 | 9.51 | 29 | 151741 | 991 | 50452363 |
Knee arthroplasty | 39.24 | 9.51 | 30 | 151740 | 35816 | 50417538 |
Bronchial secretion retention | 39.02 | 9.51 | 34 | 151736 | 1479 | 50451875 |
Ill-defined disorder | 38.82 | 9.51 | 65 | 151705 | 54589 | 50398765 |
Memory impairment | 38.72 | 9.51 | 386 | 151384 | 78974 | 50374380 |
Sinusitis | 38.32 | 9.51 | 327 | 151443 | 170231 | 50283123 |
Hallucination, visual | 38.13 | 9.51 | 123 | 151647 | 16459 | 50436895 |
Reversible cerebral vasoconstriction syndrome | 38.12 | 9.51 | 39 | 151731 | 2080 | 50451274 |
Psychomotor retardation | 37.91 | 9.51 | 49 | 151721 | 3369 | 50449985 |
Acute kidney injury | 37.79 | 9.51 | 470 | 151300 | 227588 | 50225766 |
Nasopharyngitis | 37.71 | 9.51 | 383 | 151387 | 192544 | 50260810 |
Anger | 37.68 | 9.51 | 96 | 151674 | 11237 | 50442117 |
Red blood cell sedimentation rate abnormal | 37.64 | 9.51 | 3 | 151767 | 16340 | 50437014 |
Neutropenia | 37.26 | 9.51 | 275 | 151495 | 147690 | 50305664 |
Abnormal dreams | 37.15 | 9.51 | 85 | 151685 | 9292 | 50444062 |
Pyramidal tract syndrome | 37.07 | 9.51 | 19 | 151751 | 331 | 50453023 |
Vital capacity decreased | 36.42 | 9.51 | 27 | 151743 | 929 | 50452425 |
Muscle twitching | 35.97 | 9.51 | 115 | 151655 | 15316 | 50438038 |
Mucosal inflammation | 35.25 | 9.51 | 41 | 151729 | 40101 | 50413253 |
Clonus | 34.57 | 9.51 | 52 | 151718 | 4123 | 50449231 |
Adjustment disorder with mixed anxiety and depressed mood | 34.34 | 9.51 | 12 | 151758 | 74 | 50453280 |
Anhedonia | 34.11 | 9.51 | 83 | 151687 | 9441 | 50443913 |
Mental status changes | 33.71 | 9.51 | 205 | 151565 | 36067 | 50417287 |
Cardiac arrest | 33.00 | 9.51 | 390 | 151380 | 83261 | 50370093 |
Syncope | 32.95 | 9.51 | 462 | 151308 | 102540 | 50350814 |
Pneumocystis jirovecii pneumonia | 32.93 | 9.51 | 3 | 151767 | 14660 | 50438694 |
Multiple sclerosis | 32.71 | 9.51 | 135 | 151635 | 20358 | 50432996 |
Hostility | 32.42 | 9.51 | 33 | 151737 | 1749 | 50451605 |
Small for dates baby | 32.42 | 9.51 | 46 | 151724 | 3459 | 50449895 |
Nightmare | 32.29 | 9.51 | 114 | 151656 | 15972 | 50437382 |
Bundle branch block left | 32.26 | 9.51 | 63 | 151707 | 6167 | 50447187 |
Osteoporosis | 32.22 | 9.51 | 53 | 151717 | 44826 | 50408528 |
Arthritis | 31.59 | 9.51 | 143 | 151627 | 86578 | 50366776 |
Slow speech | 31.44 | 9.51 | 28 | 151742 | 1254 | 50452100 |
Alcoholism | 31.31 | 9.51 | 31 | 151739 | 1589 | 50451765 |
Self-injurious ideation | 31.30 | 9.51 | 36 | 151734 | 2193 | 50451161 |
Multiple organ dysfunction syndrome | 31.22 | 9.51 | 65 | 151705 | 50272 | 50403082 |
Renal impairment | 31.15 | 9.51 | 119 | 151651 | 75542 | 50377812 |
Pancytopenia | 30.95 | 9.51 | 138 | 151632 | 83892 | 50369462 |
Subdural hygroma | 30.81 | 9.51 | 15 | 151755 | 233 | 50453121 |
Tachycardia | 30.52 | 9.51 | 444 | 151326 | 99319 | 50354035 |
Bradyphrenia | 30.40 | 9.51 | 61 | 151709 | 6091 | 50447263 |
Disease progression | 30.38 | 9.51 | 166 | 151604 | 95700 | 50357654 |
Libido increased | 30.19 | 9.51 | 27 | 151743 | 1216 | 50452138 |
Activation syndrome | 30.11 | 9.51 | 14 | 151756 | 195 | 50453159 |
Derealisation | 30.03 | 9.51 | 25 | 151745 | 1021 | 50452333 |
Optic nerve injury | 29.24 | 9.51 | 19 | 151751 | 526 | 50452828 |
Affective disorder | 28.81 | 9.51 | 54 | 151716 | 5127 | 50448227 |
Generalised tonic-clonic seizure | 28.58 | 9.51 | 155 | 151615 | 26155 | 50427199 |
Homicidal ideation | 28.24 | 9.51 | 30 | 151740 | 1672 | 50451682 |
Respiratory arrest | 28.14 | 9.51 | 170 | 151600 | 29839 | 50423515 |
Cerebral haematoma | 28.03 | 9.51 | 41 | 151729 | 3170 | 50450184 |
Restless legs syndrome | 28.00 | 9.51 | 108 | 151662 | 15789 | 50437565 |
Dystonia | 27.91 | 9.51 | 89 | 151681 | 11837 | 50441517 |
Congenital pulmonary valve atresia | 27.79 | 9.51 | 10 | 151760 | 68 | 50453286 |
Gestational diabetes | 27.75 | 9.51 | 66 | 151704 | 7399 | 50445955 |
Dyspnoea | 27.41 | 9.51 | 1353 | 150417 | 546255 | 49907099 |
Sputum culture positive | 27.22 | 9.51 | 27 | 151743 | 1387 | 50451967 |
Cytomegalovirus infection | 27.04 | 9.51 | 10 | 151760 | 17952 | 50435402 |
Skin ulcer | 26.98 | 9.51 | 40 | 151730 | 35278 | 50418076 |
Nausea | 26.87 | 9.51 | 2459 | 149311 | 702939 | 49750415 |
Sight disability | 26.80 | 9.51 | 11 | 151759 | 111 | 50453243 |
Thermohypoaesthesia | 26.72 | 9.51 | 11 | 151759 | 112 | 50453242 |
Treatment noncompliance | 26.51 | 9.51 | 168 | 151602 | 29982 | 50423372 |
Disorientation | 26.00 | 9.51 | 189 | 151581 | 35295 | 50418059 |
Screaming | 25.96 | 9.51 | 38 | 151732 | 2940 | 50450414 |
Gun shot wound | 25.66 | 9.51 | 10 | 151760 | 87 | 50453267 |
Platelet aggregation inhibition | 25.65 | 9.51 | 11 | 151759 | 125 | 50453229 |
Bone marrow failure | 25.59 | 9.51 | 27 | 151743 | 27597 | 50425757 |
Morose | 25.53 | 9.51 | 8 | 151762 | 33 | 50453321 |
Angle closure glaucoma | 25.50 | 9.51 | 31 | 151739 | 2003 | 50451351 |
Obsessive-compulsive disorder | 25.40 | 9.51 | 40 | 151730 | 3300 | 50450054 |
Depressive symptom | 25.28 | 9.51 | 39 | 151731 | 3161 | 50450193 |
Head injury | 25.08 | 9.51 | 140 | 151630 | 23880 | 50429474 |
Gastroschisis | 24.89 | 9.51 | 13 | 151757 | 236 | 50453118 |
Tongue biting | 24.88 | 9.51 | 25 | 151745 | 1305 | 50452049 |
Behaviour disorder | 24.67 | 9.51 | 33 | 151737 | 2347 | 50451007 |
Initial insomnia | 24.42 | 9.51 | 50 | 151720 | 5065 | 50448289 |
Musculoskeletal stiffness | 24.29 | 9.51 | 257 | 151513 | 128224 | 50325130 |
Euphoric mood | 23.47 | 9.51 | 43 | 151727 | 4012 | 50449342 |
Moaning | 23.27 | 9.51 | 19 | 151751 | 755 | 50452599 |
Bipolar disorder | 23.26 | 9.51 | 58 | 151712 | 6699 | 50446655 |
Sepsis neonatal | 23.10 | 9.51 | 15 | 151755 | 415 | 50452939 |
Rheumatoid nodule | 23.03 | 9.51 | 5 | 151765 | 12730 | 50440624 |
Hypersomnia | 22.97 | 9.51 | 99 | 151671 | 15215 | 50438139 |
Conversion disorder | 22.79 | 9.51 | 26 | 151744 | 1570 | 50451784 |
Ventricular dyskinesia | 22.69 | 9.51 | 10 | 151760 | 122 | 50453232 |
Dysarthria | 22.32 | 9.51 | 190 | 151580 | 37213 | 50416141 |
Large intestine anastomosis | 22.31 | 9.51 | 7 | 151763 | 29 | 50453325 |
Bradypnoea | 22.26 | 9.51 | 36 | 151734 | 3038 | 50450316 |
Mental impairment | 22.18 | 9.51 | 83 | 151687 | 11961 | 50441393 |
Hepatic function abnormal | 22.18 | 9.51 | 40 | 151730 | 32641 | 50420713 |
Drug screen positive | 22.17 | 9.51 | 38 | 151732 | 3364 | 50449990 |
Adverse drug reaction | 21.99 | 9.51 | 88 | 151682 | 55134 | 50398220 |
Nervousness | 21.84 | 9.51 | 150 | 151620 | 27501 | 50425853 |
Immobilisation prolonged | 21.49 | 9.51 | 9 | 151761 | 96 | 50453258 |
Negative thoughts | 21.41 | 9.51 | 19 | 151751 | 847 | 50452507 |
Hyperthermia | 21.37 | 9.51 | 61 | 151709 | 7635 | 50445719 |
Sinus tachycardia | 21.33 | 9.51 | 123 | 151647 | 21231 | 50432123 |
Myoclonus | 21.29 | 9.51 | 93 | 151677 | 14377 | 50438977 |
Pruritus | 21.25 | 9.51 | 668 | 151102 | 282900 | 50170454 |
Extradural haematoma | 21.23 | 9.51 | 25 | 151745 | 1562 | 50451792 |
Paraesthesia | 21.21 | 9.51 | 491 | 151279 | 119752 | 50333602 |
Maternal drugs affecting foetus | 21.20 | 9.51 | 47 | 151723 | 5030 | 50448324 |
Head banging | 21.13 | 9.51 | 14 | 151756 | 401 | 50452953 |
Neutropenic sepsis | 21.09 | 9.51 | 8 | 151762 | 14139 | 50439215 |
Somnambulism | 21.04 | 9.51 | 46 | 151724 | 4878 | 50448476 |
Intermenstrual bleeding | 20.89 | 9.51 | 56 | 151714 | 6758 | 50446596 |
Osteoarthritis | 20.54 | 9.51 | 121 | 151649 | 68485 | 50384869 |
Disseminated intravascular coagulation | 20.53 | 9.51 | 13 | 151757 | 17122 | 50436232 |
Emotional disorder | 20.51 | 9.51 | 80 | 151690 | 11756 | 50441598 |
Antiphospholipid antibodies | 20.50 | 9.51 | 10 | 151760 | 156 | 50453198 |
Pneumonia | 20.46 | 9.51 | 927 | 150843 | 377474 | 50075880 |
Sexual dysfunction | 20.45 | 9.51 | 36 | 151734 | 3256 | 50450098 |
Blood creatinine increased | 20.40 | 9.51 | 139 | 151631 | 76021 | 50377333 |
Bradycardia | 20.20 | 9.51 | 288 | 151482 | 64138 | 50389216 |
Pain in extremity | 20.15 | 9.51 | 644 | 151126 | 272221 | 50181133 |
Epilepsy | 20.11 | 9.51 | 122 | 151648 | 21445 | 50431909 |
Platelet count decreased | 20.06 | 9.51 | 199 | 151571 | 100527 | 50352827 |
Postictal state | 19.90 | 9.51 | 19 | 151751 | 931 | 50452423 |
Neutrophil count decreased | 19.85 | 9.51 | 71 | 151699 | 45955 | 50407399 |
Dysphoria | 19.72 | 9.51 | 44 | 151726 | 4730 | 50448624 |
Partner stress | 19.55 | 9.51 | 12 | 151758 | 300 | 50453054 |
Cytotoxic oedema | 19.51 | 9.51 | 9 | 151761 | 123 | 50453231 |
Bundle branch block right | 19.40 | 9.51 | 43 | 151727 | 4602 | 50448752 |
Thinking abnormal | 19.37 | 9.51 | 68 | 151702 | 9499 | 50443855 |
Polydipsia | 19.20 | 9.51 | 34 | 151736 | 3090 | 50450264 |
Hypervigilance | 19.14 | 9.51 | 12 | 151758 | 312 | 50453042 |
Retinal ischaemia | 19.10 | 9.51 | 12 | 151758 | 313 | 50453041 |
Cardiogenic shock | 19.09 | 9.51 | 95 | 151675 | 15504 | 50437850 |
Post-traumatic neck syndrome | 19.06 | 9.51 | 26 | 151744 | 1884 | 50451470 |
Tracheal atresia | 18.91 | 9.51 | 6 | 151764 | 26 | 50453328 |
Parkinsonism | 18.89 | 9.51 | 64 | 151706 | 8783 | 50444571 |
Libido decreased | 18.83 | 9.51 | 29 | 151741 | 2347 | 50451007 |
Bipolar I disorder | 18.81 | 9.51 | 23 | 151747 | 1495 | 50451859 |
Band sensation | 18.80 | 9.51 | 16 | 151754 | 674 | 50452680 |
Hypertensive cardiomyopathy | 18.74 | 9.51 | 10 | 151760 | 190 | 50453164 |
Ocular hypertension | 18.69 | 9.51 | 17 | 151753 | 783 | 50452571 |
Foot deformity | 18.68 | 9.51 | 18 | 151752 | 19192 | 50434162 |
Rhabdomyolysis | 18.63 | 9.51 | 189 | 151581 | 38838 | 50414516 |
Major depression | 18.57 | 9.51 | 54 | 151716 | 6830 | 50446524 |
Drowning | 18.52 | 9.51 | 13 | 151757 | 410 | 50452944 |
Hepatitis chronic active | 18.48 | 9.51 | 7 | 151763 | 56 | 50453298 |
Hyperdynamic left ventricle | 18.36 | 9.51 | 9 | 151761 | 142 | 50453212 |
Blood lactic acid | 18.34 | 9.51 | 8 | 151762 | 95 | 50453259 |
Cardiac failure | 18.33 | 9.51 | 143 | 151627 | 75897 | 50377457 |
Retroplacental haematoma | 18.25 | 9.51 | 9 | 151761 | 144 | 50453210 |
Gastrointestinal disorder | 18.23 | 9.51 | 188 | 151582 | 94268 | 50359086 |
Learning disorder | 18.22 | 9.51 | 15 | 151755 | 603 | 50452751 |
Feeling jittery | 18.19 | 9.51 | 74 | 151696 | 11086 | 50442268 |
Hyperventilation | 18.17 | 9.51 | 46 | 151724 | 5363 | 50447991 |
Cardio-respiratory arrest | 18.15 | 9.51 | 244 | 151526 | 53648 | 50399706 |
Blood prolactin increased | 18.11 | 9.51 | 33 | 151737 | 3066 | 50450288 |
Fear | 18.08 | 9.51 | 89 | 151681 | 14460 | 50438894 |
Road traffic accident | 18.00 | 9.51 | 130 | 151640 | 24222 | 50429132 |
Acute myocardial infarction | 17.98 | 9.51 | 38 | 151732 | 29235 | 50424119 |
Product administered to patient of inappropriate age | 17.97 | 9.51 | 30 | 151740 | 2600 | 50450754 |
Feeling of despair | 17.95 | 9.51 | 26 | 151744 | 1992 | 50451362 |
Amaurosis | 17.82 | 9.51 | 14 | 151756 | 526 | 50452828 |
Psychomotor skills impaired | 17.51 | 9.51 | 26 | 151744 | 2038 | 50451316 |
Unresponsive to stimuli | 17.48 | 9.51 | 154 | 151616 | 30455 | 50422899 |
Biliary dyskinesia | 17.30 | 9.51 | 29 | 151741 | 2521 | 50450833 |
Rectal ulcer | 17.24 | 9.51 | 19 | 151751 | 1104 | 50452250 |
Injury | 17.09 | 9.51 | 223 | 151547 | 48702 | 50404652 |
Hyperphagia | 17.05 | 9.51 | 22 | 151748 | 1510 | 50451844 |
Bradykinesia | 17.03 | 9.51 | 37 | 151733 | 3906 | 50449448 |
Psoriasis | 16.91 | 9.51 | 296 | 151474 | 68704 | 50384650 |
Caesarean section | 16.89 | 9.51 | 92 | 151678 | 15547 | 50437807 |
Left ventricle outflow tract obstruction | 16.88 | 9.51 | 10 | 151760 | 234 | 50453120 |
Poisoning | 16.87 | 9.51 | 78 | 151692 | 12351 | 50441003 |
Bone erosion | 16.78 | 9.51 | 7 | 151763 | 11680 | 50441674 |
Vertigo | 16.77 | 9.51 | 233 | 151537 | 51599 | 50401755 |
Anaemia | 16.73 | 9.51 | 604 | 151166 | 251852 | 50201502 |
Product substitution error | 16.71 | 9.51 | 5 | 151765 | 17 | 50453337 |
Cerebral thrombosis | 16.65 | 9.51 | 22 | 151748 | 1546 | 50451808 |
Intentional product use issue | 16.58 | 9.51 | 149 | 151621 | 76769 | 50376585 |
Barotrauma | 16.54 | 9.51 | 9 | 151761 | 178 | 50453176 |
Decreased interest | 16.53 | 9.51 | 31 | 151739 | 2945 | 50450409 |
Therapeutic product effect incomplete | 16.51 | 9.51 | 185 | 151585 | 91330 | 50362024 |
Heavy menstrual bleeding | 16.51 | 9.51 | 91 | 151679 | 15446 | 50437908 |
Colitis microscopic | 16.50 | 9.51 | 50 | 151720 | 6470 | 50446884 |
Trunk injury | 16.49 | 9.51 | 5 | 151765 | 18 | 50453336 |
Malignant neoplasm progression | 16.48 | 9.51 | 128 | 151642 | 67996 | 50385358 |
Sedation | 16.46 | 9.51 | 152 | 151618 | 30458 | 50422896 |
Tearfulness | 16.39 | 9.51 | 35 | 151735 | 3652 | 50449702 |
Sleep disorder | 16.36 | 9.51 | 252 | 151518 | 57031 | 50396323 |
Middle insomnia | 16.34 | 9.51 | 66 | 151704 | 9855 | 50443499 |
Impulsive behaviour | 16.33 | 9.51 | 21 | 151749 | 1437 | 50451917 |
Balance disorder | 16.31 | 9.51 | 300 | 151470 | 70290 | 50383064 |
Oral candidiasis | 16.27 | 9.51 | 16 | 151754 | 16899 | 50436455 |
Orgasm abnormal | 16.13 | 9.51 | 7 | 151763 | 82 | 50453272 |
Victim of sexual abuse | 16.11 | 9.51 | 13 | 151757 | 508 | 50452846 |
Panniculitis | 16.08 | 9.51 | 3 | 151767 | 8500 | 50444854 |
Uterine perforation | 16.05 | 9.51 | 49 | 151721 | 6366 | 50446988 |
Drug resistance | 16.03 | 9.51 | 20 | 151750 | 18969 | 50434385 |
Femur fracture | 16.02 | 9.51 | 58 | 151712 | 37406 | 50415948 |
Breast swelling | 16.02 | 9.51 | 18 | 151752 | 1069 | 50452285 |
Persecutory delusion | 16.00 | 9.51 | 27 | 151743 | 2360 | 50450994 |
Magnetic resonance imaging head abnormal | 15.96 | 9.51 | 23 | 151747 | 1754 | 50451600 |
Cogwheel rigidity | 15.96 | 9.51 | 23 | 151747 | 1754 | 50451600 |
Hepatitis infectious mononucleosis | 15.91 | 9.51 | 7 | 151763 | 85 | 50453269 |
Dermatitis atopic | 15.89 | 9.51 | 34 | 151736 | 3552 | 50449802 |
Red blood cell sedimentation rate increased | 15.81 | 9.51 | 41 | 151729 | 29375 | 50423979 |
Interstitial lung disease | 15.80 | 9.51 | 94 | 151676 | 53082 | 50400272 |
Ventricular fibrillation | 15.64 | 9.51 | 68 | 151702 | 10491 | 50442863 |
Respiratory disorder | 15.62 | 9.51 | 45 | 151725 | 31142 | 50422212 |
Exercise lack of | 15.56 | 9.51 | 11 | 151759 | 351 | 50453003 |
Osteonecrosis of jaw | 15.52 | 9.51 | 48 | 151722 | 32478 | 50420876 |
Septic shock | 15.49 | 9.51 | 104 | 151666 | 57071 | 50396283 |
Hemianopia | 15.44 | 9.51 | 16 | 151754 | 866 | 50452488 |
Self-medication | 15.41 | 9.51 | 26 | 151744 | 2273 | 50451081 |
Concussion | 15.26 | 9.51 | 54 | 151716 | 7574 | 50445780 |
Dry mouth | 15.24 | 9.51 | 245 | 151525 | 55933 | 50397421 |
Gallbladder disorder | 15.16 | 9.51 | 94 | 151676 | 16648 | 50436706 |
Orthostatic hypotension | 15.16 | 9.51 | 145 | 151625 | 29336 | 50424018 |
Transplant rejection | 15.06 | 9.51 | 5 | 151765 | 9604 | 50443750 |
Musculoskeletal pain | 15.04 | 9.51 | 141 | 151629 | 72036 | 50381318 |
Congenital diaphragmatic eventration | 14.88 | 9.51 | 4 | 151766 | 8 | 50453346 |
Anti-actin antibody positive | 14.88 | 9.51 | 4 | 151766 | 8 | 50453346 |
Panic reaction | 14.86 | 9.51 | 33 | 151737 | 3536 | 50449818 |
Hypokalaemia | 14.80 | 9.51 | 357 | 151413 | 87635 | 50365719 |
Alcohol abuse | 14.78 | 9.51 | 23 | 151747 | 1878 | 50451476 |
Tinnitus | 14.78 | 9.51 | 139 | 151631 | 27993 | 50425361 |
Hypertension | 14.75 | 9.51 | 502 | 151268 | 210701 | 50242653 |
Fibromyalgia | 14.73 | 9.51 | 77 | 151693 | 44901 | 50408453 |
Hypocoagulable state | 14.65 | 9.51 | 16 | 151754 | 920 | 50452434 |
Carcinoid syndrome | 14.59 | 9.51 | 7 | 151763 | 105 | 50453249 |
Transposition of the great vessels | 14.54 | 9.51 | 8 | 151762 | 162 | 50453192 |
Prothrombin level increased | 14.52 | 9.51 | 9 | 151761 | 229 | 50453125 |
Soft tissue injury | 14.51 | 9.51 | 20 | 151750 | 1464 | 50451890 |
Neuromyelitis optica spectrum disorder | 14.49 | 9.51 | 15 | 151755 | 811 | 50452543 |
Psychiatric symptom | 14.46 | 9.51 | 38 | 151732 | 4532 | 50448822 |
Cellulitis | 14.46 | 9.51 | 139 | 151631 | 70659 | 50382695 |
Weight increased | 14.41 | 9.51 | 742 | 151028 | 201149 | 50252205 |
Right ventricular dilatation | 14.38 | 9.51 | 16 | 151754 | 940 | 50452414 |
Drug dependence | 14.33 | 9.51 | 105 | 151665 | 19654 | 50433700 |
Obsessive thoughts | 14.27 | 9.51 | 12 | 151758 | 497 | 50452857 |
Bursitis | 14.22 | 9.51 | 28 | 151742 | 22107 | 50431247 |
Dissociation | 14.16 | 9.51 | 25 | 151745 | 2266 | 50451088 |
Haemoglobin urine | 14.14 | 9.51 | 7 | 151763 | 113 | 50453241 |
Alcohol use | 13.96 | 9.51 | 23 | 151747 | 1972 | 50451382 |
Cardiac hypertrophy | 13.93 | 9.51 | 16 | 151754 | 973 | 50452381 |
Fracture | 13.92 | 9.51 | 18 | 151752 | 16815 | 50436539 |
Pupil fixed | 13.81 | 9.51 | 20 | 151750 | 1532 | 50451822 |
Flight of ideas | 13.80 | 9.51 | 10 | 151760 | 332 | 50453022 |
Stoma site discharge | 13.71 | 9.51 | 18 | 151752 | 1257 | 50452097 |
Spinal cord oedema | 13.71 | 9.51 | 7 | 151763 | 121 | 50453233 |
Attention-seeking behaviour | 13.56 | 9.51 | 6 | 151764 | 74 | 50453280 |
Extensor plantar response | 13.52 | 9.51 | 17 | 151753 | 1137 | 50452217 |
Torticollis | 13.49 | 9.51 | 21 | 151749 | 1715 | 50451639 |
Wheezing | 13.45 | 9.51 | 120 | 151650 | 61927 | 50391427 |
Myocardial infarction | 13.42 | 9.51 | 187 | 151583 | 88840 | 50364514 |
Focal dyscognitive seizures | 13.39 | 9.51 | 27 | 151743 | 2705 | 50450649 |
White blood cell count decreased | 13.36 | 9.51 | 258 | 151512 | 116464 | 50336890 |
Brain injury | 13.28 | 9.51 | 44 | 151726 | 5970 | 50447384 |
Dextrocardia | 13.28 | 9.51 | 4 | 151766 | 14 | 50453340 |
Vision blurred | 13.20 | 9.51 | 319 | 151451 | 78328 | 50375026 |
Lethargy | 13.19 | 9.51 | 215 | 151555 | 49217 | 50404137 |
Staring | 13.13 | 9.51 | 19 | 151751 | 1455 | 50451899 |
Cerebellar syndrome | 13.10 | 9.51 | 30 | 151740 | 3281 | 50450073 |
Atrioventricular block | 13.08 | 9.51 | 46 | 151724 | 6432 | 50446922 |
Pulmonary contusion | 13.06 | 9.51 | 4 | 151766 | 15 | 50453339 |
Cough | 13.02 | 9.51 | 591 | 151179 | 240673 | 50212681 |
Colour blindness | 12.99 | 9.51 | 9 | 151761 | 278 | 50453076 |
Disinhibition | 12.95 | 9.51 | 14 | 151756 | 796 | 50452558 |
Bundle branch block | 12.92 | 9.51 | 14 | 151756 | 798 | 50452556 |
Mood swings | 12.87 | 9.51 | 87 | 151683 | 15867 | 50437487 |
Apnoea | 12.82 | 9.51 | 48 | 151722 | 6918 | 50446436 |
Joint hyperextension | 12.76 | 9.51 | 9 | 151761 | 286 | 50453068 |
Substance abuse | 12.75 | 9.51 | 34 | 151736 | 4090 | 50449264 |
Superior sagittal sinus thrombosis | 12.69 | 9.51 | 13 | 151757 | 694 | 50452660 |
Tonsillitis | 12.69 | 9.51 | 38 | 151732 | 4885 | 50448469 |
Haemophagocytic lymphohistiocytosis | 12.67 | 9.51 | 5 | 151765 | 8628 | 50444726 |
Snoring | 12.67 | 9.51 | 30 | 151740 | 3354 | 50450000 |
Ovarian vein thrombosis | 12.59 | 9.51 | 5 | 151765 | 46 | 50453308 |
Narrow anterior chamber angle | 12.59 | 9.51 | 5 | 151765 | 46 | 50453308 |
Haematotoxicity | 12.57 | 9.51 | 4 | 151766 | 7891 | 50445463 |
Suspected suicide | 12.56 | 9.51 | 40 | 151730 | 5317 | 50448037 |
Nuchal rigidity | 12.42 | 9.51 | 12 | 151758 | 597 | 50452757 |
Anterograde amnesia | 12.38 | 9.51 | 11 | 151759 | 491 | 50452863 |
Cerebral arteriovenous malformation haemorrhagic | 12.37 | 9.51 | 3 | 151767 | 3 | 50453351 |
Wrong product procured | 12.37 | 9.51 | 3 | 151767 | 3 | 50453351 |
Metamyelocyte count increased | 12.27 | 9.51 | 8 | 151762 | 223 | 50453131 |
Mucosal ulceration | 12.26 | 9.51 | 14 | 151756 | 846 | 50452508 |
Bile acid malabsorption | 12.24 | 9.51 | 7 | 151763 | 153 | 50453201 |
Haemorrhagic stroke | 12.22 | 9.51 | 39 | 151731 | 5189 | 50448165 |
Immunodeficiency | 12.12 | 9.51 | 16 | 151754 | 14812 | 50438542 |
Multimorbidity | 11.89 | 9.51 | 11 | 151759 | 518 | 50452836 |
Cor pulmonale acute | 11.86 | 9.51 | 9 | 151761 | 321 | 50453033 |
Sleep-related eating disorder | 11.80 | 9.51 | 13 | 151757 | 755 | 50452599 |
Social avoidant behaviour | 11.80 | 9.51 | 26 | 151744 | 2771 | 50450583 |
Holoprosencephaly | 11.68 | 9.51 | 4 | 151766 | 23 | 50453331 |
Creatinine urine decreased | 11.66 | 9.51 | 7 | 151763 | 168 | 50453186 |
Migraine | 11.64 | 9.51 | 302 | 151468 | 74978 | 50378376 |
Impaired driving ability | 11.59 | 9.51 | 32 | 151738 | 3929 | 50449425 |
Gambling disorder | 11.53 | 9.51 | 16 | 151754 | 1178 | 50452176 |
Coma scale abnormal | 11.53 | 9.51 | 36 | 151734 | 4735 | 50448619 |
Retching | 11.51 | 9.51 | 72 | 151698 | 12790 | 50440564 |
Convulsive threshold lowered | 11.50 | 9.51 | 9 | 151761 | 336 | 50453018 |
Laryngectomy | 11.40 | 9.51 | 4 | 151766 | 25 | 50453329 |
Metastases to bone | 11.36 | 9.51 | 23 | 151747 | 17972 | 50435382 |
Choroidal effusion | 11.30 | 9.51 | 10 | 151760 | 444 | 50452910 |
Sternal fracture | 11.30 | 9.51 | 21 | 151749 | 1981 | 50451373 |
Enterococcus test positive | 11.30 | 9.51 | 15 | 151755 | 1059 | 50452295 |
Lung diffusion disorder | 11.27 | 9.51 | 5 | 151765 | 62 | 50453292 |
Neonatal respiratory depression | 11.27 | 9.51 | 5 | 151765 | 62 | 50453292 |
Poor quality sleep | 11.25 | 9.51 | 87 | 151683 | 16559 | 50436795 |
Xerophthalmia | 11.17 | 9.51 | 9 | 151761 | 351 | 50453003 |
Atrophy of globe | 11.16 | 9.51 | 3 | 151767 | 6 | 50453348 |
Meningocele | 11.16 | 9.51 | 3 | 151767 | 6 | 50453348 |
Wound healing normal | 11.16 | 9.51 | 3 | 151767 | 6 | 50453348 |
Tonic clonic movements | 11.10 | 9.51 | 16 | 151754 | 1221 | 50452133 |
Antipsychotic drug level increased | 11.03 | 9.51 | 27 | 151743 | 3082 | 50450272 |
Tachyphrenia | 11.02 | 9.51 | 16 | 151754 | 1229 | 50452125 |
Head titubation | 10.98 | 9.51 | 12 | 151758 | 691 | 50452663 |
Blood pressure diastolic decreased | 10.98 | 9.51 | 21 | 151749 | 16760 | 50436594 |
Sialoadenitis | 10.97 | 9.51 | 17 | 151753 | 1383 | 50451971 |
Pulseless electrical activity | 10.86 | 9.51 | 45 | 151725 | 6796 | 50446558 |
Aphasia | 10.86 | 9.51 | 132 | 151638 | 28362 | 50424992 |
Post concussion syndrome | 10.84 | 9.51 | 10 | 151760 | 469 | 50452885 |
Enthesopathy | 10.83 | 9.51 | 4 | 151766 | 7189 | 50446165 |
Optic atrophy | 10.79 | 9.51 | 15 | 151755 | 1107 | 50452247 |
General physical health deterioration | 10.78 | 9.51 | 335 | 151435 | 142099 | 50311255 |
Compulsive shopping | 10.77 | 9.51 | 12 | 151758 | 706 | 50452648 |
Menometrorrhagia | 10.74 | 9.51 | 13 | 151757 | 836 | 50452518 |
Periorbital haemorrhage | 10.67 | 9.51 | 5 | 151765 | 71 | 50453283 |
CSF pressure increased | 10.66 | 9.51 | 6 | 151764 | 127 | 50453227 |
Acute myeloid leukaemia | 10.63 | 9.51 | 18 | 151752 | 15056 | 50438298 |
Blood cholesterol increased | 10.61 | 9.51 | 110 | 151660 | 55105 | 50398249 |
Mitochondrial myopathy | 10.61 | 9.51 | 5 | 151765 | 72 | 50453282 |
Ejection fraction decreased | 10.59 | 9.51 | 25 | 151745 | 18495 | 50434859 |
Creatinine renal clearance decreased | 10.57 | 9.51 | 12 | 151758 | 11869 | 50441485 |
Exposure via breast milk | 10.53 | 9.51 | 18 | 151752 | 1590 | 50451764 |
Electrocardiogram P wave abnormal | 10.49 | 9.51 | 7 | 151763 | 203 | 50453151 |
Flat affect | 10.44 | 9.51 | 16 | 151754 | 1289 | 50452065 |
Compulsions | 10.43 | 9.51 | 7 | 151763 | 205 | 50453149 |
Upper-airway cough syndrome | 10.41 | 9.51 | 52 | 151718 | 8498 | 50444856 |
Sluggishness | 10.39 | 9.51 | 33 | 151737 | 4380 | 50448974 |
Hypernatraemia | 10.37 | 9.51 | 42 | 151728 | 6279 | 50447075 |
Live birth | 10.33 | 9.51 | 21 | 151749 | 16387 | 50436967 |
Macular degeneration | 10.32 | 9.51 | 17 | 151753 | 14371 | 50438983 |
Incoherent | 10.29 | 9.51 | 32 | 151738 | 4198 | 50449156 |
Feeling hot | 10.27 | 9.51 | 170 | 151600 | 39032 | 50414322 |
Logorrhoea | 10.26 | 9.51 | 22 | 151748 | 2302 | 50451052 |
Pancreatic carcinoma recurrent | 10.25 | 9.51 | 5 | 151765 | 78 | 50453276 |
Essential tremor | 10.24 | 9.51 | 13 | 151757 | 878 | 50452476 |
Apallic syndrome | 10.22 | 9.51 | 11 | 151759 | 622 | 50452732 |
Haematoma | 10.21 | 9.51 | 138 | 151632 | 30372 | 50422982 |
Biliary colic | 10.21 | 9.51 | 27 | 151743 | 3232 | 50450122 |
Neonatal asphyxia | 10.19 | 9.51 | 7 | 151763 | 213 | 50453141 |
Therapeutic response unexpected | 10.11 | 9.51 | 82 | 151688 | 15833 | 50437521 |
Immune-mediated myositis | 10.09 | 9.51 | 14 | 151756 | 1031 | 50452323 |
Disturbance in sexual arousal | 10.08 | 9.51 | 5 | 151765 | 81 | 50453273 |
Neoplasm progression | 10.07 | 9.51 | 49 | 151721 | 29108 | 50424246 |
Congenital tracheomalacia | 10.05 | 9.51 | 4 | 151766 | 37 | 50453317 |
Diplopia | 10.03 | 9.51 | 95 | 151675 | 19165 | 50434189 |
Oesophageal atresia | 10.03 | 9.51 | 10 | 151760 | 517 | 50452837 |
Housebound | 10.02 | 9.51 | 7 | 151763 | 219 | 50453135 |
Tubulointerstitial nephritis | 9.98 | 9.51 | 19 | 151751 | 15192 | 50438162 |
Multiple allergies | 9.97 | 9.51 | 51 | 151719 | 8412 | 50444942 |
Endometrial disorder | 9.93 | 9.51 | 11 | 151759 | 643 | 50452711 |
Amenorrhoea | 9.91 | 9.51 | 51 | 151719 | 8433 | 50444921 |
Cluster headache | 9.90 | 9.51 | 10 | 151760 | 525 | 50452829 |
Tic | 9.85 | 9.51 | 15 | 151755 | 1202 | 50452152 |
Belligerence | 9.85 | 9.51 | 6 | 151764 | 148 | 50453206 |
Psychotic disorder due to a general medical condition | 9.80 | 9.51 | 7 | 151763 | 227 | 50453127 |
Micturition disorder | 9.79 | 9.51 | 19 | 151751 | 1852 | 50451502 |
Catatonia | 9.78 | 9.51 | 29 | 151741 | 3707 | 50449647 |
Yawning | 9.77 | 9.51 | 13 | 151757 | 920 | 50452434 |
Erythema | 9.75 | 9.51 | 350 | 151420 | 146064 | 50307290 |
Sleep talking | 9.73 | 9.51 | 13 | 151757 | 923 | 50452431 |
Electrocardiogram U wave present | 9.71 | 9.51 | 5 | 151765 | 88 | 50453266 |
Skin necrosis | 9.65 | 9.51 | 11 | 151759 | 10856 | 50442498 |
Splenic thrombosis | 9.65 | 9.51 | 3 | 151767 | 12 | 50453342 |
Blood osmolarity increased | 9.64 | 9.51 | 6 | 151764 | 154 | 50453200 |
Inappropriate affect | 9.63 | 9.51 | 12 | 151758 | 795 | 50452559 |
Speech disorder | 9.63 | 9.51 | 155 | 151615 | 35393 | 50417961 |
Basilar migraine | 9.61 | 9.51 | 4 | 151766 | 42 | 50453312 |
Anorgasmia | 9.60 | 9.51 | 10 | 151760 | 545 | 50452809 |
Osteonecrosis | 9.53 | 9.51 | 35 | 151735 | 22482 | 50430872 |
Device placement issue | 9.53 | 9.51 | 12 | 151758 | 804 | 50452550 |
Polyarthritis | 9.51 | 9.51 | 6 | 151764 | 7921 | 50445433 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Serotonin syndrome | 423.62 | 10.02 | 340 | 68270 | 17172 | 29488745 |
Completed suicide | 293.76 | 10.02 | 647 | 67963 | 89599 | 29416318 |
Suicidal ideation | 284.54 | 10.02 | 376 | 68234 | 34340 | 29471577 |
Suicide attempt | 247.08 | 10.02 | 348 | 68262 | 33762 | 29472155 |
Intentional overdose | 227.29 | 10.02 | 357 | 68253 | 38171 | 29467746 |
Agitation | 172.56 | 10.02 | 373 | 68237 | 50931 | 29454986 |
Anxiety | 151.67 | 10.02 | 489 | 68121 | 84876 | 29421041 |
Aggression | 132.99 | 10.02 | 270 | 68340 | 35271 | 29470646 |
Somnolence | 128.71 | 10.02 | 494 | 68116 | 93461 | 29412456 |
Foetal exposure during pregnancy | 124.01 | 10.02 | 255 | 68355 | 33612 | 29472305 |
Depression | 115.21 | 10.02 | 446 | 68164 | 84701 | 29421216 |
Tremor | 114.42 | 10.02 | 403 | 68207 | 73135 | 29432782 |
Sopor | 106.25 | 10.02 | 129 | 68481 | 10805 | 29495112 |
Intentional self-injury | 100.51 | 10.02 | 134 | 68476 | 12327 | 29493590 |
Overdose | 90.51 | 10.02 | 396 | 68214 | 79423 | 29426494 |
Electrocardiogram QT prolonged | 90.20 | 10.02 | 234 | 68376 | 35903 | 29470014 |
Paranoia | 88.69 | 10.02 | 112 | 68498 | 9765 | 29496152 |
Poisoning deliberate | 87.89 | 10.02 | 86 | 68524 | 5645 | 29500272 |
Mania | 87.10 | 10.02 | 104 | 68506 | 8559 | 29497358 |
Sexual dysfunction | 79.53 | 10.02 | 82 | 68528 | 5732 | 29500185 |
Withdrawal syndrome | 79.29 | 10.02 | 112 | 68498 | 10880 | 29495037 |
Drug interaction | 75.62 | 10.02 | 744 | 67866 | 196641 | 29309276 |
Febrile neutropenia | 69.80 | 10.02 | 95 | 68515 | 112145 | 29393772 |
Intrusive thoughts | 69.19 | 10.02 | 25 | 68585 | 230 | 29505687 |
Restlessness | 66.52 | 10.02 | 154 | 68456 | 21991 | 29483926 |
Maternal drugs affecting foetus | 66.49 | 10.02 | 62 | 68548 | 3831 | 29502086 |
Drug withdrawal syndrome | 65.31 | 10.02 | 135 | 68475 | 17849 | 29488068 |
Muscle rigidity | 65.10 | 10.02 | 94 | 68516 | 9317 | 29496600 |
Insomnia | 63.34 | 10.02 | 387 | 68223 | 88374 | 29417543 |
Disturbance in attention | 63.27 | 10.02 | 148 | 68462 | 21276 | 29484641 |
Fall | 62.62 | 10.02 | 657 | 67953 | 176521 | 29329396 |
Coma | 61.12 | 10.02 | 216 | 68394 | 39234 | 29466683 |
Dyskinesia | 60.79 | 10.02 | 140 | 68470 | 19921 | 29485996 |
Confusional state | 60.62 | 10.02 | 505 | 68105 | 127372 | 29378545 |
Irritability | 57.90 | 10.02 | 146 | 68464 | 22006 | 29483911 |
Activation syndrome | 56.41 | 10.02 | 17 | 68593 | 82 | 29505835 |
Major depression | 55.93 | 10.02 | 56 | 68554 | 3779 | 29502138 |
Erectile dysfunction | 54.92 | 10.02 | 126 | 68484 | 17883 | 29488034 |
Loss of libido | 54.24 | 10.02 | 44 | 68566 | 2252 | 29503665 |
Apathy | 53.86 | 10.02 | 69 | 68541 | 6102 | 29499815 |
Anger | 53.50 | 10.02 | 93 | 68517 | 10797 | 29495120 |
Interstitial lung disease | 53.37 | 10.02 | 34 | 68576 | 57684 | 29448233 |
Panic attack | 53.03 | 10.02 | 80 | 68530 | 8246 | 29497671 |
Hyperhidrosis | 52.91 | 10.02 | 292 | 68318 | 64248 | 29441669 |
Thrombocytopenia | 52.74 | 10.02 | 150 | 68460 | 134673 | 29371244 |
Sedation | 52.22 | 10.02 | 121 | 68489 | 17284 | 29488633 |
Product substitution issue | 51.28 | 10.02 | 83 | 68527 | 9089 | 29496828 |
Libido decreased | 50.62 | 10.02 | 56 | 68554 | 4242 | 29501675 |
Pyrexia | 50.07 | 10.02 | 427 | 68183 | 287195 | 29218722 |
Neutropenia | 49.73 | 10.02 | 149 | 68461 | 131562 | 29374355 |
Septic shock | 48.70 | 10.02 | 44 | 68566 | 62516 | 29443401 |
Pneumonia | 48.57 | 10.02 | 492 | 68118 | 319680 | 29186237 |
Hypomania | 47.87 | 10.02 | 40 | 68570 | 2135 | 29503782 |
Akathisia | 47.60 | 10.02 | 68 | 68542 | 6674 | 29499243 |
Renal impairment | 47.42 | 10.02 | 72 | 68538 | 81261 | 29424656 |
Anorgasmia | 45.47 | 10.02 | 24 | 68586 | 583 | 29505334 |
Gun shot wound | 44.40 | 10.02 | 29 | 68581 | 1056 | 29504861 |
Hallucination | 44.07 | 10.02 | 213 | 68397 | 44499 | 29461418 |
Parkinsonism | 43.64 | 10.02 | 68 | 68542 | 7210 | 29498707 |
Hallucination, visual | 43.54 | 10.02 | 103 | 68507 | 14912 | 29491005 |
Mycotic allergy | 43.47 | 10.02 | 18 | 68592 | 246 | 29505671 |
Abulia | 43.45 | 10.02 | 22 | 68588 | 489 | 29505428 |
Tardive dyskinesia | 43.09 | 10.02 | 57 | 68553 | 5201 | 29500716 |
Tachyphrenia | 42.44 | 10.02 | 29 | 68581 | 1140 | 29504777 |
Respiratory disorder neonatal | 41.70 | 10.02 | 31 | 68579 | 1394 | 29504523 |
Chest injury | 41.54 | 10.02 | 31 | 68579 | 1402 | 29504515 |
Sepsis | 40.91 | 10.02 | 181 | 68429 | 142501 | 29363416 |
Homicidal ideation | 40.82 | 10.02 | 39 | 68571 | 2485 | 29503432 |
Bipolar disorder | 40.67 | 10.02 | 44 | 68566 | 3251 | 29502666 |
Mite allergy | 40.30 | 10.02 | 18 | 68592 | 299 | 29505618 |
Renal failure | 40.01 | 10.02 | 141 | 68469 | 118458 | 29387459 |
Mood swings | 39.70 | 10.02 | 65 | 68545 | 7186 | 29498731 |
Neuroleptic malignant syndrome | 39.69 | 10.02 | 104 | 68506 | 16044 | 29489873 |
Mydriasis | 39.51 | 10.02 | 59 | 68551 | 6026 | 29499891 |
Malignant neoplasm progression | 38.76 | 10.02 | 70 | 68540 | 73789 | 29432128 |
Acute kidney injury | 38.39 | 10.02 | 412 | 68198 | 264855 | 29241062 |
Spirometry abnormal | 37.32 | 10.02 | 18 | 68592 | 359 | 29505558 |
Sleep disorder | 37.31 | 10.02 | 133 | 68477 | 24253 | 29481664 |
Alcoholism | 37.24 | 10.02 | 38 | 68572 | 2623 | 29503294 |
Hallucination, auditory | 37.19 | 10.02 | 74 | 68536 | 9519 | 29496398 |
Drug withdrawal syndrome neonatal | 36.19 | 10.02 | 42 | 68568 | 3353 | 29502564 |
Memory impairment | 36.13 | 10.02 | 174 | 68436 | 36296 | 29469621 |
Anaemia | 35.95 | 10.02 | 296 | 68314 | 200655 | 29305262 |
Multiple organ dysfunction syndrome | 35.71 | 10.02 | 57 | 68553 | 63059 | 29442858 |
Foetal malformation | 35.47 | 10.02 | 13 | 68597 | 125 | 29505792 |
Abnormal behaviour | 35.26 | 10.02 | 126 | 68484 | 23001 | 29482916 |
Infusion related reaction | 35.19 | 10.02 | 30 | 68580 | 43856 | 29462061 |
Amnesia | 35.07 | 10.02 | 124 | 68486 | 22519 | 29483398 |
Seizure | 34.56 | 10.02 | 349 | 68261 | 92774 | 29413143 |
Trisomy 18 | 34.44 | 10.02 | 14 | 68596 | 182 | 29505735 |
Hyperreflexia | 34.18 | 10.02 | 37 | 68573 | 2735 | 29503182 |
Resting tremor | 34.18 | 10.02 | 20 | 68590 | 597 | 29505320 |
Social avoidant behaviour | 34.08 | 10.02 | 38 | 68572 | 2904 | 29503013 |
Homicide | 33.64 | 10.02 | 23 | 68587 | 905 | 29505012 |
Bone marrow failure | 33.38 | 10.02 | 11 | 68599 | 27438 | 29478479 |
Impulsive behaviour | 33.29 | 10.02 | 31 | 68579 | 1912 | 29504005 |
Conjunctivitis allergic | 33.21 | 10.02 | 20 | 68590 | 630 | 29505287 |
Dust allergy | 32.89 | 10.02 | 18 | 68592 | 471 | 29505446 |
Small for dates baby | 32.79 | 10.02 | 41 | 68569 | 3538 | 29502379 |
Walking aid user | 32.17 | 10.02 | 27 | 68583 | 1450 | 29504467 |
Electrocardiogram QT interval | 31.83 | 10.02 | 9 | 68601 | 33 | 29505884 |
Anencephaly | 31.72 | 10.02 | 12 | 68598 | 127 | 29505790 |
Loss of consciousness | 31.66 | 10.02 | 286 | 68324 | 73770 | 29432147 |
Painful respiration | 30.95 | 10.02 | 24 | 68586 | 1150 | 29504767 |
Skin dystrophy | 30.64 | 10.02 | 7 | 68603 | 7 | 29505910 |
Dyspnoea | 30.61 | 10.02 | 554 | 68056 | 326178 | 29179739 |
Delusion | 30.43 | 10.02 | 75 | 68535 | 11141 | 29494776 |
Postural orthostatic tachycardia syndrome | 30.28 | 10.02 | 9 | 68601 | 41 | 29505876 |
Psychotic disorder | 30.27 | 10.02 | 110 | 68500 | 20244 | 29485673 |
Prescribed overdose | 30.14 | 10.02 | 64 | 68546 | 8619 | 29497298 |
Electrocardiogram QRS complex prolonged | 29.82 | 10.02 | 42 | 68568 | 4068 | 29501849 |
Rheumatoid arthritis | 29.63 | 10.02 | 19 | 68591 | 32133 | 29473784 |
Depressed mood | 28.93 | 10.02 | 94 | 68516 | 16354 | 29489563 |
Cerebral haematoma | 28.39 | 10.02 | 42 | 68568 | 4254 | 29501663 |
Delirium | 28.20 | 10.02 | 172 | 68438 | 39225 | 29466692 |
Craniosynostosis | 28.16 | 10.02 | 14 | 68596 | 299 | 29505618 |
Blood creatinine increased | 28.13 | 10.02 | 102 | 68508 | 85000 | 29420917 |
Clonus | 28.03 | 10.02 | 31 | 68579 | 2347 | 29503570 |
Feeling abnormal | 27.90 | 10.02 | 219 | 68391 | 54226 | 29451691 |
Drug screen positive | 27.81 | 10.02 | 39 | 68571 | 3762 | 29502155 |
Consciousness fluctuating | 27.74 | 10.02 | 21 | 68589 | 971 | 29504946 |
Congenital ureteropelvic junction obstruction | 27.30 | 10.02 | 9 | 68601 | 61 | 29505856 |
Alcohol use | 27.30 | 10.02 | 35 | 68575 | 3097 | 29502820 |
Psychomotor retardation | 27.11 | 10.02 | 34 | 68576 | 2942 | 29502975 |
Reversible cerebral vasoconstriction syndrome | 27.10 | 10.02 | 13 | 68597 | 256 | 29505661 |
Psychomotor hyperactivity | 26.75 | 10.02 | 59 | 68551 | 8154 | 29497763 |
Self esteem decreased | 26.65 | 10.02 | 16 | 68594 | 501 | 29505416 |
Lactic acidosis | 26.37 | 10.02 | 19 | 68591 | 30228 | 29475689 |
Disorientation | 25.83 | 10.02 | 136 | 68474 | 29379 | 29476538 |
Myoclonus | 25.18 | 10.02 | 78 | 68532 | 13231 | 29492686 |
Depressed level of consciousness | 25.01 | 10.02 | 159 | 68451 | 36783 | 29469134 |
Depressive symptom | 24.91 | 10.02 | 25 | 68585 | 1692 | 29504225 |
Extrapyramidal disorder | 24.84 | 10.02 | 68 | 68542 | 10763 | 29495154 |
Bradypnoea | 24.72 | 10.02 | 29 | 68581 | 2342 | 29503575 |
Bruxism | 24.68 | 10.02 | 24 | 68586 | 1563 | 29504354 |
Hyperthermia | 24.48 | 10.02 | 62 | 68548 | 9368 | 29496549 |
Catatonia | 24.39 | 10.02 | 40 | 68570 | 4428 | 29501489 |
Apraxia | 24.25 | 10.02 | 21 | 68589 | 1177 | 29504740 |
Platelet count decreased | 24.18 | 10.02 | 143 | 68467 | 104529 | 29401388 |
Libido increased | 24.09 | 10.02 | 17 | 68593 | 704 | 29505213 |
Emotional disorder | 24.07 | 10.02 | 42 | 68568 | 4889 | 29501028 |
Respiratory failure | 23.89 | 10.02 | 130 | 68480 | 97001 | 29408916 |
Anhedonia | 23.77 | 10.02 | 52 | 68558 | 7148 | 29498769 |
Cogwheel rigidity | 23.58 | 10.02 | 21 | 68589 | 1222 | 29504695 |
Gynaecomastia | 23.42 | 10.02 | 56 | 68554 | 8161 | 29497756 |
Cardiac failure | 23.05 | 10.02 | 100 | 68510 | 79187 | 29426730 |
Torsade de pointes | 23.01 | 10.02 | 49 | 68561 | 6612 | 29499305 |
Gambling disorder | 22.97 | 10.02 | 23 | 68587 | 1552 | 29504365 |
Derealisation | 22.54 | 10.02 | 15 | 68595 | 564 | 29505353 |
Agitation neonatal | 22.37 | 10.02 | 19 | 68591 | 1037 | 29504880 |
Hypersomnia | 22.20 | 10.02 | 65 | 68545 | 10689 | 29495228 |
Legal problem | 22.18 | 10.02 | 10 | 68600 | 170 | 29505747 |
Feeling guilty | 22.14 | 10.02 | 12 | 68598 | 308 | 29505609 |
Reduced facial expression | 22.11 | 10.02 | 16 | 68594 | 690 | 29505227 |
Gastrointestinal hypermotility | 21.93 | 10.02 | 9 | 68601 | 120 | 29505797 |
Orgasm abnormal | 21.67 | 10.02 | 9 | 68601 | 124 | 29505793 |
Priapism | 21.61 | 10.02 | 38 | 68572 | 4450 | 29501467 |
Neonatal respiratory distress | 21.58 | 10.02 | 14 | 68596 | 504 | 29505413 |
Neonatal pneumonia | 21.54 | 10.02 | 9 | 68601 | 126 | 29505791 |
Total lung capacity abnormal | 21.54 | 10.02 | 9 | 68601 | 126 | 29505791 |
Pregnancy | 21.50 | 10.02 | 11 | 68599 | 250 | 29505667 |
Electrocardiogram QT interval abnormal | 21.46 | 10.02 | 8 | 68602 | 81 | 29505836 |
Negative thoughts | 21.46 | 10.02 | 15 | 68595 | 612 | 29505305 |
Cardiac failure congestive | 21.41 | 10.02 | 98 | 68512 | 76483 | 29429434 |
Off label use | 21.14 | 10.02 | 534 | 68076 | 300266 | 29205651 |
Contraindicated product administered | 21.05 | 10.02 | 8 | 68602 | 18258 | 29487659 |
Disseminated intravascular coagulation | 21.03 | 10.02 | 10 | 68600 | 19970 | 29485947 |
Cytomegalovirus infection | 21.01 | 10.02 | 14 | 68596 | 23201 | 29482716 |
Disinhibition | 20.96 | 10.02 | 28 | 68582 | 2579 | 29503338 |
Tension | 20.95 | 10.02 | 24 | 68586 | 1889 | 29504028 |
Burnout syndrome | 20.74 | 10.02 | 9 | 68601 | 139 | 29505778 |
Physical deconditioning | 20.67 | 10.02 | 16 | 68594 | 765 | 29505152 |
Abnormal dreams | 20.63 | 10.02 | 48 | 68562 | 6872 | 29499045 |
Inhibitory drug interaction | 20.59 | 10.02 | 21 | 68589 | 1449 | 29504468 |
Crying | 20.41 | 10.02 | 41 | 68569 | 5310 | 29500607 |
Congenital hearing disorder | 20.40 | 10.02 | 8 | 68602 | 94 | 29505823 |
Persecutory delusion | 20.37 | 10.02 | 25 | 68585 | 2116 | 29503801 |
Parkinsonian gait | 20.36 | 10.02 | 13 | 68597 | 455 | 29505462 |
Poor quality sleep | 20.30 | 10.02 | 49 | 68561 | 7184 | 29498733 |
Urinary retention | 20.19 | 10.02 | 135 | 68475 | 31763 | 29474154 |
Muscle necrosis | 20.17 | 10.02 | 16 | 68594 | 793 | 29505124 |
Condition aggravated | 19.99 | 10.02 | 462 | 68148 | 145833 | 29360084 |
Judgement impaired | 19.88 | 10.02 | 14 | 68596 | 578 | 29505339 |
Cognitive disorder | 19.69 | 10.02 | 107 | 68503 | 23392 | 29482525 |
Ejaculation disorder | 19.66 | 10.02 | 17 | 68593 | 951 | 29504966 |
Hypoglycaemia neonatal | 19.51 | 10.02 | 22 | 68588 | 1702 | 29504215 |
Trisomy 21 | 19.41 | 10.02 | 13 | 68597 | 494 | 29505423 |
Poisoning | 19.31 | 10.02 | 59 | 68551 | 9934 | 29495983 |
Septum pellucidum agenesis | 19.22 | 10.02 | 7 | 68603 | 66 | 29505851 |
Atrial septal defect | 19.06 | 10.02 | 46 | 68564 | 6743 | 29499174 |
Infantile apnoea | 18.91 | 10.02 | 16 | 68594 | 869 | 29505048 |
Retrograde amnesia | 18.89 | 10.02 | 8 | 68602 | 116 | 29505801 |
Bronchopulmonary aspergillosis | 18.87 | 10.02 | 3 | 68607 | 12341 | 29493576 |
Infection | 18.72 | 10.02 | 103 | 68507 | 76648 | 29429269 |
Brain stem haematoma | 18.65 | 10.02 | 8 | 68602 | 120 | 29505797 |
Mental disorder | 18.56 | 10.02 | 69 | 68541 | 12836 | 29493081 |
Rash | 18.30 | 10.02 | 320 | 68290 | 189499 | 29316418 |
Dysgraphia | 18.12 | 10.02 | 23 | 68587 | 2015 | 29503902 |
Reactive psychosis | 18.04 | 10.02 | 4 | 68606 | 3 | 29505914 |
Physical assault | 18.00 | 10.02 | 17 | 68593 | 1067 | 29504850 |
Pancytopenia | 17.96 | 10.02 | 116 | 68494 | 83052 | 29422865 |
Stomatitis | 17.87 | 10.02 | 37 | 68573 | 37076 | 29468841 |
Pruritus | 17.85 | 10.02 | 179 | 68431 | 116670 | 29389247 |
Toxic epidermal necrolysis | 17.74 | 10.02 | 10 | 68600 | 18143 | 29487774 |
Bradykinesia | 17.67 | 10.02 | 30 | 68580 | 3417 | 29502500 |
Congenital pulmonary hypertension | 17.56 | 10.02 | 6 | 68604 | 46 | 29505871 |
Neonatal seizure | 17.55 | 10.02 | 12 | 68598 | 472 | 29505445 |
Electrocardiogram QT shortened | 17.48 | 10.02 | 8 | 68602 | 141 | 29505776 |
Persistent depressive disorder | 17.47 | 10.02 | 10 | 68600 | 286 | 29505631 |
Death | 17.44 | 10.02 | 634 | 67976 | 341450 | 29164467 |
Obsessive-compulsive disorder | 17.38 | 10.02 | 35 | 68575 | 4541 | 29501376 |
Pain in extremity | 17.36 | 10.02 | 168 | 68442 | 110265 | 29395652 |
Neutrophil count decreased | 17.35 | 10.02 | 48 | 68562 | 43519 | 29462398 |
Ascites | 17.22 | 10.02 | 37 | 68573 | 36582 | 29469335 |
Gastrointestinal haemorrhage | 17.14 | 10.02 | 111 | 68499 | 79422 | 29426495 |
Inappropriate antidiuretic hormone secretion | 17.04 | 10.02 | 60 | 68550 | 10872 | 29495045 |
Pelvic kidney | 17.01 | 10.02 | 7 | 68603 | 94 | 29505823 |
Exposure during pregnancy | 16.99 | 10.02 | 51 | 68559 | 8503 | 29497414 |
Oedema peripheral | 16.94 | 10.02 | 156 | 68454 | 103401 | 29402516 |
Drug resistance | 16.93 | 10.02 | 15 | 68595 | 21525 | 29484392 |
Mental impairment | 16.76 | 10.02 | 53 | 68557 | 9088 | 29496829 |
Drug eruption | 16.69 | 10.02 | 9 | 68601 | 16732 | 29489185 |
Hypertonia | 16.63 | 10.02 | 31 | 68579 | 3798 | 29502119 |
Erythema | 16.56 | 10.02 | 105 | 68505 | 75501 | 29430416 |
Urticaria | 16.46 | 10.02 | 68 | 68542 | 54592 | 29451325 |
Nightmare | 16.38 | 10.02 | 61 | 68549 | 11356 | 29494561 |
Feeling of despair | 16.36 | 10.02 | 15 | 68595 | 907 | 29505010 |
Orthostatic hypotension | 16.32 | 10.02 | 99 | 68511 | 22530 | 29483387 |
Postictal psychosis | 16.25 | 10.02 | 8 | 68602 | 167 | 29505750 |
Toxic encephalopathy | 16.01 | 10.02 | 34 | 68576 | 4578 | 29501339 |
Renal dysplasia | 15.83 | 10.02 | 8 | 68602 | 177 | 29505740 |
Bradyphrenia | 15.73 | 10.02 | 32 | 68578 | 4182 | 29501735 |
Feelings of worthlessness | 15.71 | 10.02 | 9 | 68601 | 258 | 29505659 |
Personality disorder | 15.65 | 10.02 | 16 | 68594 | 1107 | 29504810 |
Congenital hydronephrosis | 15.62 | 10.02 | 13 | 68597 | 690 | 29505227 |
Depersonalisation/derealisation disorder | 15.59 | 10.02 | 12 | 68598 | 569 | 29505348 |
Neutropenic sepsis | 15.54 | 10.02 | 4 | 68606 | 11723 | 29494194 |
Cough | 15.50 | 10.02 | 204 | 68406 | 126523 | 29379394 |
Stress | 15.48 | 10.02 | 94 | 68516 | 21396 | 29484521 |
Medication error | 15.42 | 10.02 | 93 | 68517 | 21118 | 29484799 |
Helplessness | 15.42 | 10.02 | 6 | 68604 | 69 | 29505848 |
Neuropathy peripheral | 15.37 | 10.02 | 99 | 68511 | 70928 | 29434989 |
Aspergillus infection | 15.24 | 10.02 | 3 | 68607 | 10578 | 29495339 |
Leukopenia | 15.21 | 10.02 | 71 | 68539 | 55132 | 29450785 |
Sleep-related eating disorder | 15.13 | 10.02 | 9 | 68601 | 277 | 29505640 |
Neonatal hyponatraemia | 15.12 | 10.02 | 6 | 68604 | 73 | 29505844 |
Alcohol abuse | 15.11 | 10.02 | 32 | 68578 | 4301 | 29501616 |
Haemophagocytic lymphohistiocytosis | 15.09 | 10.02 | 3 | 68607 | 10501 | 29495416 |
Head discomfort | 15.03 | 10.02 | 27 | 68583 | 3215 | 29502702 |
Hyperglycaemia | 15.02 | 10.02 | 36 | 68574 | 34251 | 29471666 |
Family stress | 14.92 | 10.02 | 7 | 68603 | 131 | 29505786 |
Atrial fibrillation | 14.85 | 10.02 | 165 | 68445 | 105481 | 29400436 |
Weight increased | 14.77 | 10.02 | 255 | 68355 | 76412 | 29429505 |
Ejaculation failure | 14.63 | 10.02 | 13 | 68597 | 754 | 29505163 |
Palmar-plantar erythrodysaesthesia syndrome | 14.61 | 10.02 | 8 | 68602 | 14751 | 29491166 |
Dementia with Lewy bodies | 14.59 | 10.02 | 12 | 68598 | 626 | 29505291 |
Hepatotoxicity | 14.58 | 10.02 | 12 | 68598 | 17855 | 29488062 |
Inflammation | 14.34 | 10.02 | 19 | 68591 | 22709 | 29483208 |
Muscle twitching | 14.23 | 10.02 | 46 | 68564 | 7980 | 29497937 |
Sperm concentration decreased | 14.14 | 10.02 | 7 | 68603 | 148 | 29505769 |
Somatic symptom disorder | 14.06 | 10.02 | 11 | 68599 | 534 | 29505383 |
Pneumocystis jirovecii pneumonia | 14.03 | 10.02 | 11 | 68599 | 16768 | 29489149 |
Hypersensitivity | 14.02 | 10.02 | 69 | 68541 | 52834 | 29453083 |
Renal haemorrhage | 13.96 | 10.02 | 16 | 68594 | 1260 | 29504657 |
Swelling | 13.95 | 10.02 | 39 | 68571 | 35244 | 29470673 |
White blood cell count decreased | 13.88 | 10.02 | 125 | 68485 | 83237 | 29422680 |
Tearfulness | 13.82 | 10.02 | 18 | 68592 | 1618 | 29504299 |
Personality change | 13.64 | 10.02 | 32 | 68578 | 4606 | 29501311 |
Stress at work | 13.61 | 10.02 | 7 | 68603 | 161 | 29505756 |
Illness anxiety disorder | 13.49 | 10.02 | 7 | 68603 | 164 | 29505753 |
Pneumonitis | 13.46 | 10.02 | 28 | 68582 | 28016 | 29477901 |
Human herpesvirus 6 infection | 13.46 | 10.02 | 19 | 68591 | 1844 | 29504073 |
Rabbit syndrome | 13.32 | 10.02 | 4 | 68606 | 19 | 29505898 |
Graft versus host disease | 13.32 | 10.02 | 3 | 68607 | 9625 | 29496292 |
Dementia | 13.30 | 10.02 | 58 | 68552 | 11600 | 29494317 |
Panic disorder | 13.15 | 10.02 | 15 | 68595 | 1175 | 29504742 |
Delusional disorder, erotomanic type | 13.13 | 10.02 | 3 | 68607 | 3 | 29505914 |
Rapid eye movements sleep abnormal | 13.12 | 10.02 | 7 | 68603 | 174 | 29505743 |
Tumour lysis syndrome | 13.07 | 10.02 | 8 | 68602 | 13876 | 29492041 |
Device dislocation | 13.06 | 10.02 | 31 | 68579 | 4496 | 29501421 |
Joint swelling | 12.99 | 10.02 | 65 | 68545 | 49565 | 29456352 |
Nasopharyngitis | 12.99 | 10.02 | 83 | 68527 | 59582 | 29446335 |
Loss of employment | 12.94 | 10.02 | 10 | 68600 | 477 | 29505440 |
Ureteric haemorrhage | 12.90 | 10.02 | 6 | 68604 | 110 | 29505807 |
Epilepsy | 12.88 | 10.02 | 80 | 68530 | 18352 | 29487565 |
Yawning | 12.88 | 10.02 | 10 | 68600 | 480 | 29505437 |
Feeling jittery | 12.87 | 10.02 | 27 | 68583 | 3606 | 29502311 |
Social fear | 12.67 | 10.02 | 3 | 68607 | 4 | 29505913 |
Arthralgia | 12.61 | 10.02 | 238 | 68372 | 139379 | 29366538 |
Myocardial infarction | 12.61 | 10.02 | 180 | 68430 | 110116 | 29395801 |
Somnambulism | 12.59 | 10.02 | 23 | 68587 | 2775 | 29503142 |
Dizziness | 12.58 | 10.02 | 549 | 68061 | 189135 | 29316782 |
Hyperammonaemic encephalopathy | 12.50 | 10.02 | 19 | 68591 | 1971 | 29503946 |
Premature ejaculation | 12.42 | 10.02 | 6 | 68604 | 120 | 29505797 |
Treatment failure | 12.38 | 10.02 | 44 | 68566 | 36895 | 29469022 |
Symptom recurrence | 12.26 | 10.02 | 8 | 68602 | 291 | 29505626 |
Thinking abnormal | 12.13 | 10.02 | 33 | 68577 | 5203 | 29500714 |
Electrocardiogram abnormal | 12.12 | 10.02 | 41 | 68569 | 7281 | 29498636 |
Frustration tolerance decreased | 12.07 | 10.02 | 20 | 68590 | 2232 | 29503685 |
Selective eating disorder | 12.07 | 10.02 | 17 | 68593 | 1646 | 29504271 |
Paresis | 12.07 | 10.02 | 18 | 68592 | 1836 | 29504081 |
Congenital megaureter | 12.03 | 10.02 | 6 | 68604 | 129 | 29505788 |
Carbon dioxide increased | 12.01 | 10.02 | 13 | 68597 | 961 | 29504956 |
Haemoglobin decreased | 11.99 | 10.02 | 178 | 68432 | 108197 | 29397720 |
Delusion of grandeur | 11.85 | 10.02 | 9 | 68601 | 418 | 29505499 |
Logorrhoea | 11.84 | 10.02 | 20 | 68590 | 2268 | 29503649 |
Acute myocardial infarction | 11.81 | 10.02 | 65 | 68545 | 48373 | 29457544 |
Grandiosity | 11.72 | 10.02 | 8 | 68602 | 314 | 29505603 |
Mucosal inflammation | 11.71 | 10.02 | 36 | 68574 | 31559 | 29474358 |
Cleft lip and palate | 11.69 | 10.02 | 8 | 68602 | 315 | 29505602 |
Exposure via breast milk | 11.69 | 10.02 | 17 | 68593 | 1695 | 29504222 |
Hepatic failure | 11.61 | 10.02 | 36 | 68574 | 31476 | 29474441 |
Sprue-like enteropathy | 11.61 | 10.02 | 9 | 68601 | 431 | 29505486 |
Pleural effusion | 11.46 | 10.02 | 109 | 68501 | 71799 | 29434118 |
Prescription form tampering | 11.40 | 10.02 | 9 | 68601 | 443 | 29505474 |
Mood altered | 11.36 | 10.02 | 43 | 68567 | 8068 | 29497849 |
Obsessive-compulsive personality disorder | 11.32 | 10.02 | 6 | 68604 | 147 | 29505770 |
Back pain | 11.31 | 10.02 | 168 | 68442 | 102116 | 29403801 |
Anaphylactic reaction | 11.26 | 10.02 | 30 | 68580 | 27543 | 29478374 |
Chronic kidney disease | 11.15 | 10.02 | 45 | 68565 | 36371 | 29469546 |
Suture rupture | 11.09 | 10.02 | 8 | 68602 | 343 | 29505574 |
Attention deficit hyperactivity disorder | 10.97 | 10.02 | 19 | 68591 | 2198 | 29503719 |
Post-traumatic stress disorder | 10.92 | 10.02 | 16 | 68594 | 1606 | 29504311 |
Theft | 10.86 | 10.02 | 7 | 68603 | 249 | 29505668 |
Obsessive thoughts | 10.80 | 10.02 | 10 | 68600 | 612 | 29505305 |
Multiple drug therapy | 10.77 | 10.02 | 8 | 68602 | 359 | 29505558 |
Screaming | 10.77 | 10.02 | 14 | 68596 | 1256 | 29504661 |
Urogenital haemorrhage | 10.76 | 10.02 | 9 | 68601 | 481 | 29505436 |
Imprisonment | 10.76 | 10.02 | 9 | 68601 | 481 | 29505436 |
Behaviour disorder | 10.69 | 10.02 | 25 | 68585 | 3591 | 29502326 |
Onycholysis | 10.66 | 10.02 | 9 | 68601 | 487 | 29505430 |
Neonatal tachypnoea | 10.63 | 10.02 | 6 | 68604 | 167 | 29505750 |
Impaired work ability | 10.62 | 10.02 | 33 | 68577 | 5607 | 29500310 |
Diffuse alopecia | 10.61 | 10.02 | 3 | 68607 | 11 | 29505906 |
Microvascular coronary artery disease | 10.60 | 10.02 | 4 | 68606 | 42 | 29505875 |
Affect lability | 10.59 | 10.02 | 24 | 68586 | 3378 | 29502539 |
Urinary incontinence | 10.58 | 10.02 | 70 | 68540 | 16411 | 29489506 |
Skin exfoliation | 10.54 | 10.02 | 23 | 68587 | 22622 | 29483295 |
Congenital diaphragmatic hernia | 10.52 | 10.02 | 7 | 68603 | 263 | 29505654 |
Flat affect | 10.52 | 10.02 | 11 | 68599 | 781 | 29505136 |
Hypocalcaemia | 10.46 | 10.02 | 20 | 68590 | 20645 | 29485272 |
Dissociation | 10.45 | 10.02 | 13 | 68597 | 1116 | 29504801 |
Tinnitus | 10.44 | 10.02 | 67 | 68543 | 15547 | 29490370 |
Hyponatriuria | 10.41 | 10.02 | 3 | 68607 | 12 | 29505905 |
Nephropathy toxic | 10.40 | 10.02 | 6 | 68604 | 10750 | 29495167 |
Coronary artery disease | 10.39 | 10.02 | 60 | 68550 | 44130 | 29461787 |
Feminisation acquired | 10.36 | 10.02 | 4 | 68606 | 45 | 29505872 |
Hypospadias | 10.27 | 10.02 | 22 | 68588 | 2980 | 29502937 |
Posterior reversible encephalopathy syndrome | 10.23 | 10.02 | 4 | 68606 | 8972 | 29496945 |
Male orgasmic disorder | 10.22 | 10.02 | 5 | 68605 | 103 | 29505814 |
Cerebrospinal fluid circulation disorder | 10.21 | 10.02 | 3 | 68607 | 13 | 29505904 |
Soft tissue disorder | 10.15 | 10.02 | 10 | 68600 | 662 | 29505255 |
Fluid retention | 10.11 | 10.02 | 25 | 68585 | 23535 | 29482382 |
Compulsions | 10.11 | 10.02 | 6 | 68604 | 184 | 29505733 |
Cryptorchism | 10.08 | 10.02 | 17 | 68593 | 1925 | 29503992 |
Hallucination, olfactory | 10.08 | 10.02 | 6 | 68604 | 185 | 29505732 |
Renal tubular necrosis | 10.06 | 10.02 | 11 | 68599 | 14304 | 29491613 |
Autonomic nervous system imbalance | 10.03 | 10.02 | 19 | 68591 | 2357 | 29503560 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Serotonin syndrome | 613.75 | 9.67 | 636 | 172305 | 38646 | 64287145 |
Suicide attempt | 580.67 | 9.67 | 828 | 172113 | 70179 | 64255612 |
Suicidal ideation | 576.91 | 9.67 | 798 | 172143 | 65744 | 64260047 |
Intentional overdose | 526.32 | 9.67 | 899 | 172042 | 89045 | 64236746 |
Completed suicide | 514.32 | 9.67 | 1543 | 171398 | 222871 | 64102920 |
Electrocardiogram QT prolonged | 415.45 | 9.67 | 756 | 172185 | 78692 | 64247099 |
Sopor | 404.63 | 9.67 | 447 | 172494 | 29214 | 64296577 |
Anxiety | 324.57 | 9.67 | 1236 | 171705 | 201413 | 64124378 |
Somnolence | 293.73 | 9.67 | 1202 | 171739 | 202443 | 64123348 |
Overdose | 271.00 | 9.67 | 992 | 171949 | 158574 | 64167217 |
Drug interaction | 232.71 | 9.67 | 1714 | 171227 | 360369 | 63965422 |
Depression | 226.67 | 9.67 | 1033 | 171908 | 182258 | 64143533 |
Agitation | 225.44 | 9.67 | 632 | 172309 | 87735 | 64238056 |
Tremor | 216.00 | 9.67 | 878 | 172063 | 147352 | 64178439 |
Intentional self-injury | 192.15 | 9.67 | 307 | 172634 | 28737 | 64297054 |
Coma | 183.09 | 9.67 | 584 | 172357 | 87031 | 64238760 |
Synovitis | 174.85 | 9.67 | 28 | 172913 | 99062 | 64226729 |
Poisoning deliberate | 153.53 | 9.67 | 185 | 172756 | 13273 | 64312518 |
Pemphigus | 147.85 | 9.67 | 3 | 172938 | 60698 | 64265093 |
Product substitution issue | 146.91 | 9.67 | 209 | 172732 | 17652 | 64308139 |
Contraindicated product administered | 146.37 | 9.67 | 53 | 172888 | 107776 | 64218015 |
Withdrawal syndrome | 144.12 | 9.67 | 240 | 172701 | 23252 | 64302539 |
Mania | 142.03 | 9.67 | 196 | 172745 | 16090 | 64309701 |
Drug intolerance | 133.93 | 9.67 | 185 | 172756 | 187807 | 64137984 |
Fall | 132.90 | 9.67 | 1703 | 171238 | 415123 | 63910668 |
Joint swelling | 132.45 | 9.67 | 234 | 172707 | 215148 | 64110643 |
Hand deformity | 130.15 | 9.67 | 10 | 172931 | 62761 | 64263030 |
Febrile neutropenia | 128.41 | 9.67 | 190 | 172751 | 187467 | 64138324 |
Akathisia | 124.45 | 9.67 | 154 | 172787 | 11356 | 64314435 |
Aggression | 123.13 | 9.67 | 336 | 172605 | 45896 | 64279895 |
Arthropathy | 123.03 | 9.67 | 87 | 172854 | 120880 | 64204911 |
Treatment failure | 122.83 | 9.67 | 81 | 172860 | 116735 | 64209056 |
Inappropriate antidiuretic hormone secretion | 122.66 | 9.67 | 217 | 172724 | 22072 | 64303719 |
Infusion related reaction | 119.00 | 9.67 | 160 | 172781 | 164307 | 64161484 |
Paranoia | 118.11 | 9.67 | 180 | 172761 | 16172 | 64309619 |
Hyponatraemia | 116.89 | 9.67 | 739 | 172202 | 147600 | 64178191 |
Irritability | 111.07 | 9.67 | 280 | 172661 | 36466 | 64289325 |
Panic attack | 108.92 | 9.67 | 199 | 172742 | 20754 | 64305037 |
Muscle rigidity | 107.84 | 9.67 | 179 | 172762 | 17294 | 64308497 |
Seizure | 104.58 | 9.67 | 786 | 172155 | 166106 | 64159685 |
Torsade de pointes | 103.33 | 9.67 | 175 | 172766 | 17188 | 64308603 |
Systemic lupus erythematosus | 102.22 | 9.67 | 40 | 172901 | 77572 | 64248219 |
Mydriasis | 100.10 | 9.67 | 161 | 172780 | 15151 | 64310640 |
Tardive dyskinesia | 97.95 | 9.67 | 122 | 172819 | 9056 | 64316735 |
Acute kidney injury | 94.19 | 9.67 | 762 | 172179 | 448478 | 63877313 |
Confusional state | 93.48 | 9.67 | 1091 | 171850 | 260053 | 64065738 |
Disturbance in attention | 90.55 | 9.67 | 279 | 172662 | 40795 | 64284996 |
Swelling | 88.91 | 9.67 | 185 | 172756 | 160033 | 64165758 |
Insomnia | 87.78 | 9.67 | 863 | 172078 | 196973 | 64128818 |
Sepsis | 87.46 | 9.67 | 320 | 172621 | 230021 | 64095770 |
Mental disorder | 86.80 | 9.67 | 208 | 172733 | 26237 | 64299554 |
Hyperhidrosis | 86.68 | 9.67 | 603 | 172338 | 124317 | 64201474 |
Neutropenia | 86.39 | 9.67 | 340 | 172601 | 239284 | 64086507 |
Dyskinesia | 86.33 | 9.67 | 267 | 172674 | 39121 | 64286670 |
Apathy | 83.05 | 9.67 | 125 | 172816 | 11107 | 64314684 |
Restlessness | 82.88 | 9.67 | 265 | 172676 | 39520 | 64286271 |
Loss of consciousness | 81.53 | 9.67 | 678 | 172263 | 147687 | 64178104 |
Duodenal ulcer perforation | 79.57 | 9.67 | 3 | 172938 | 34622 | 64291169 |
Crying | 79.28 | 9.67 | 170 | 172771 | 19920 | 64305871 |
Multiple organ dysfunction syndrome | 79.23 | 9.67 | 93 | 172848 | 101320 | 64224471 |
Drug withdrawal syndrome | 78.95 | 9.67 | 223 | 172718 | 31068 | 64294723 |
Helicobacter infection | 77.08 | 9.67 | 7 | 172934 | 38355 | 64287436 |
Glossodynia | 76.32 | 9.67 | 39 | 172902 | 64657 | 64261134 |
Neuroleptic malignant syndrome | 76.09 | 9.67 | 191 | 172750 | 24805 | 64300986 |
Electrocardiogram QRS complex prolonged | 75.77 | 9.67 | 108 | 172833 | 9136 | 64316655 |
Drug ineffective | 75.39 | 9.67 | 1699 | 171242 | 838548 | 63487243 |
Renal impairment | 73.14 | 9.67 | 158 | 172783 | 134859 | 64190932 |
Hyperreflexia | 73.07 | 9.67 | 93 | 172848 | 7055 | 64318736 |
Pyrexia | 72.61 | 9.67 | 1058 | 171883 | 557586 | 63768205 |
Rheumatoid arthritis | 71.45 | 9.67 | 215 | 172726 | 164079 | 64161712 |
Anger | 70.10 | 9.67 | 140 | 172801 | 15601 | 64310190 |
Sexual dysfunction | 69.03 | 9.67 | 86 | 172855 | 6385 | 64319406 |
Peripheral swelling | 69.02 | 9.67 | 307 | 172634 | 208846 | 64116945 |
Sympathomimetic effect | 68.65 | 9.67 | 19 | 172922 | 52 | 64325739 |
Pericarditis | 67.54 | 9.67 | 42 | 172899 | 62474 | 64263317 |
Infection | 67.45 | 9.67 | 261 | 172680 | 184619 | 64141172 |
Arthralgia | 67.12 | 9.67 | 811 | 172130 | 441449 | 63884342 |
Rash | 66.54 | 9.67 | 849 | 172092 | 457700 | 63868091 |
Hallucination | 66.48 | 9.67 | 377 | 172564 | 72411 | 64253380 |
Lower respiratory tract infection | 66.44 | 9.67 | 94 | 172847 | 94520 | 64231271 |
Wound | 65.44 | 9.67 | 65 | 172876 | 76412 | 64249379 |
Stomatitis | 62.97 | 9.67 | 124 | 172817 | 109481 | 64216310 |
Long QT syndrome | 62.50 | 9.67 | 73 | 172868 | 5066 | 64320725 |
Clonus | 62.12 | 9.67 | 79 | 172862 | 5988 | 64319803 |
Psychotic disorder | 62.00 | 9.67 | 219 | 172722 | 34359 | 64291432 |
Depressed mood | 61.29 | 9.67 | 245 | 172696 | 40767 | 64285024 |
Interstitial lung disease | 61.09 | 9.67 | 105 | 172836 | 97627 | 64228164 |
Activation syndrome | 60.67 | 9.67 | 24 | 172917 | 247 | 64325544 |
Off label use | 60.54 | 9.67 | 1266 | 171675 | 631540 | 63694251 |
Depressed level of consciousness | 59.98 | 9.67 | 399 | 172542 | 81037 | 64244754 |
Bruxism | 58.95 | 9.67 | 60 | 172881 | 3564 | 64322227 |
Septic shock | 58.26 | 9.67 | 122 | 172819 | 105315 | 64220476 |
Gun shot wound | 58.12 | 9.67 | 36 | 172905 | 1028 | 64324763 |
Reversible cerebral vasoconstriction syndrome | 57.96 | 9.67 | 49 | 172892 | 2293 | 64323498 |
Intrusive thoughts | 56.86 | 9.67 | 25 | 172916 | 342 | 64325449 |
Multiple sclerosis relapse | 56.16 | 9.67 | 239 | 172702 | 40896 | 64284895 |
Derealisation | 56.03 | 9.67 | 40 | 172901 | 1455 | 64324336 |
Hypersensitivity | 55.79 | 9.67 | 304 | 172637 | 196148 | 64129643 |
Pancytopenia | 55.74 | 9.67 | 197 | 172744 | 143112 | 64182679 |
Pneumonia | 55.72 | 9.67 | 1112 | 171829 | 558464 | 63767327 |
Hallucination, auditory | 55.34 | 9.67 | 133 | 172808 | 16806 | 64308985 |
Drug hypersensitivity | 55.11 | 9.67 | 392 | 172549 | 237423 | 64088368 |
Extrapyramidal disorder | 54.97 | 9.67 | 145 | 172796 | 19407 | 64306384 |
Cytomegalovirus infection | 54.48 | 9.67 | 16 | 172925 | 37183 | 64288608 |
Abnormal behaviour | 54.43 | 9.67 | 206 | 172735 | 33416 | 64292375 |
C-reactive protein abnormal | 54.03 | 9.67 | 7 | 172934 | 29040 | 64296751 |
Libido decreased | 53.32 | 9.67 | 65 | 172876 | 4719 | 64321072 |
Psychomotor hyperactivity | 53.29 | 9.67 | 119 | 172822 | 14332 | 64311459 |
Thrombocytopenia | 52.78 | 9.67 | 367 | 172574 | 223434 | 64102357 |
Hallucination, visual | 52.26 | 9.67 | 179 | 172762 | 27655 | 64298136 |
Folliculitis | 51.93 | 9.67 | 9 | 172932 | 30068 | 64295723 |
Anhedonia | 51.82 | 9.67 | 114 | 172827 | 13592 | 64312199 |
Alopecia | 51.80 | 9.67 | 248 | 172693 | 165442 | 64160349 |
Myelosuppression | 51.73 | 9.67 | 3 | 172938 | 23827 | 64301964 |
Alcoholism | 50.96 | 9.67 | 54 | 172887 | 3363 | 64322428 |
Inflammation | 50.87 | 9.67 | 60 | 172881 | 65240 | 64260551 |
Amnesia | 50.85 | 9.67 | 260 | 172681 | 48009 | 64277782 |
Cardiac failure | 50.79 | 9.67 | 183 | 172758 | 132190 | 64193601 |
Platelet count decreased | 50.71 | 9.67 | 254 | 172687 | 167457 | 64158334 |
Hypertonia | 50.52 | 9.67 | 73 | 172868 | 6252 | 64319539 |
Muscle injury | 50.08 | 9.67 | 6 | 172935 | 26431 | 64299360 |
Delusion | 50.04 | 9.67 | 133 | 172808 | 17881 | 64307910 |
Homicidal ideation | 49.51 | 9.67 | 52 | 172889 | 3205 | 64322586 |
Memory impairment | 49.43 | 9.67 | 396 | 172545 | 85286 | 64240505 |
Bone marrow failure | 49.38 | 9.67 | 34 | 172907 | 47918 | 64277873 |
Cholecystitis chronic | 49.27 | 9.67 | 89 | 172852 | 9198 | 64316593 |
Impaired healing | 48.81 | 9.67 | 54 | 172887 | 60419 | 64265372 |
Galactorrhoea | 48.24 | 9.67 | 51 | 172890 | 3168 | 64322623 |
C-reactive protein increased | 48.19 | 9.67 | 115 | 172826 | 94794 | 64230997 |
Cerebral haematoma | 47.58 | 9.67 | 76 | 172865 | 7109 | 64318682 |
Libido increased | 47.51 | 9.67 | 39 | 172902 | 1751 | 64324040 |
Mucosal inflammation | 47.17 | 9.67 | 59 | 172882 | 62525 | 64263266 |
Loss of libido | 46.96 | 9.67 | 44 | 172897 | 2360 | 64323431 |
Bipolar disorder | 45.44 | 9.67 | 72 | 172869 | 6689 | 64319102 |
Psychomotor retardation | 45.00 | 9.67 | 62 | 172879 | 5081 | 64320710 |
Dyspnoea | 44.26 | 9.67 | 1531 | 171410 | 717143 | 63608648 |
Toxicity to various agents | 44.03 | 9.67 | 1281 | 171660 | 362232 | 63963559 |
Parkinsonism | 43.92 | 9.67 | 110 | 172831 | 14263 | 64311528 |
Abnormal dreams | 43.61 | 9.67 | 90 | 172851 | 10266 | 64315525 |
Feeling abnormal | 43.29 | 9.67 | 548 | 172393 | 133054 | 64192737 |
Major depression | 42.87 | 9.67 | 76 | 172865 | 7740 | 64318051 |
Muscle twitching | 42.75 | 9.67 | 130 | 172811 | 18868 | 64306923 |
Emotional distress | 42.15 | 9.67 | 200 | 172741 | 35838 | 64289953 |
Anaemia | 42.12 | 9.67 | 738 | 172203 | 377942 | 63947849 |
Blood creatinine increased | 41.98 | 9.67 | 204 | 172737 | 135578 | 64190213 |
Tachyphrenia | 41.87 | 9.67 | 37 | 172904 | 1839 | 64323952 |
Death | 41.42 | 9.67 | 982 | 171959 | 481723 | 63844068 |
Hepatic enzyme increased | 40.89 | 9.67 | 194 | 172747 | 129749 | 64196042 |
Hypomania | 40.49 | 9.67 | 62 | 172879 | 5592 | 64320199 |
Suicidal behaviour | 40.20 | 9.67 | 44 | 172897 | 2843 | 64322948 |
Dizziness | 39.99 | 9.67 | 1469 | 171472 | 428694 | 63897097 |
Pregnancy | 39.89 | 9.67 | 135 | 172806 | 20730 | 64305061 |
Drug screen positive | 39.88 | 9.67 | 62 | 172879 | 5667 | 64320124 |
Adjustment disorder with mixed anxiety and depressed mood | 39.50 | 9.67 | 13 | 172928 | 74 | 64325717 |
Disseminated intravascular coagulation | 38.90 | 9.67 | 19 | 172922 | 32329 | 64293462 |
Tonsillar ulcer | 38.71 | 9.67 | 20 | 172921 | 399 | 64325392 |
Pneumocystis jirovecii pneumonia | 38.48 | 9.67 | 13 | 172928 | 27621 | 64298170 |
Abulia | 38.46 | 9.67 | 26 | 172915 | 865 | 64324926 |
Hyperthermia | 38.42 | 9.67 | 110 | 172831 | 15440 | 64310351 |
Sleep disorder | 38.36 | 9.67 | 283 | 172658 | 59426 | 64266365 |
Spirometry abnormal | 37.99 | 9.67 | 22 | 172919 | 554 | 64325237 |
Screaming | 37.80 | 9.67 | 47 | 172894 | 3482 | 64322309 |
Bradypnoea | 37.55 | 9.67 | 57 | 172884 | 5102 | 64320689 |
Malignant neoplasm progression | 37.00 | 9.67 | 166 | 172775 | 112705 | 64213086 |
Multiple sclerosis | 36.60 | 9.67 | 123 | 172818 | 18818 | 64306973 |
Alcohol use | 36.59 | 9.67 | 53 | 172888 | 4549 | 64321242 |
Bradyphrenia | 36.43 | 9.67 | 79 | 172862 | 9327 | 64316464 |
Impulsive behaviour | 36.07 | 9.67 | 40 | 172901 | 2623 | 64323168 |
Neutrophil count decreased | 35.75 | 9.67 | 98 | 172843 | 77098 | 64248693 |
Social avoidant behaviour | 35.53 | 9.67 | 52 | 172889 | 4505 | 64321286 |
Hypersomnia | 35.45 | 9.67 | 125 | 172816 | 19592 | 64306199 |
Blister | 35.14 | 9.67 | 106 | 172835 | 80861 | 64244930 |
Nightmare | 35.12 | 9.67 | 130 | 172811 | 20863 | 64304928 |
Hepatic function abnormal | 35.03 | 9.67 | 75 | 172866 | 64238 | 64261553 |
Reversible airways obstruction | 34.92 | 9.67 | 27 | 172914 | 1111 | 64324680 |
Therapeutic product effect decreased | 34.11 | 9.67 | 176 | 172765 | 115175 | 64210616 |
Neutropenic sepsis | 34.10 | 9.67 | 10 | 172931 | 23262 | 64302529 |
Disorientation | 33.83 | 9.67 | 261 | 172680 | 55567 | 64270224 |
Abdominal discomfort | 33.77 | 9.67 | 319 | 172622 | 182003 | 64143788 |
Self esteem decreased | 33.14 | 9.67 | 24 | 172917 | 893 | 64324898 |
Myocardial infarction | 32.95 | 9.67 | 285 | 172656 | 165536 | 64160255 |
Discomfort | 32.91 | 9.67 | 109 | 172832 | 80769 | 64245022 |
Sinus bradycardia | 32.80 | 9.67 | 135 | 172806 | 22758 | 64303033 |
Optic nerve injury | 32.61 | 9.67 | 20 | 172921 | 561 | 64325230 |
Drug abuse | 32.46 | 9.67 | 517 | 172424 | 131857 | 64193934 |
Sedation | 32.26 | 9.67 | 206 | 172735 | 41256 | 64284535 |
Vital capacity decreased | 31.95 | 9.67 | 25 | 172916 | 1047 | 64324744 |
Negative thoughts | 31.44 | 9.67 | 27 | 172914 | 1291 | 64324500 |
Myoclonus | 31.29 | 9.67 | 142 | 172799 | 24976 | 64300815 |
Emotional disorder | 30.97 | 9.67 | 89 | 172852 | 12518 | 64313273 |
Oculogyric crisis | 30.78 | 9.67 | 36 | 172905 | 2502 | 64323289 |
Mobility decreased | 30.76 | 9.67 | 122 | 172819 | 85718 | 64240073 |
Orgasm abnormal | 30.44 | 9.67 | 13 | 172928 | 165 | 64325626 |
Aspergillus infection | 30.34 | 9.67 | 4 | 172937 | 16375 | 64309416 |
Anorgasmia | 30.18 | 9.67 | 23 | 172918 | 926 | 64324865 |
Pain in extremity | 29.86 | 9.67 | 603 | 172338 | 302482 | 64023309 |
Resting tremor | 29.80 | 9.67 | 27 | 172914 | 1387 | 64324404 |
Acute myocardial infarction | 29.74 | 9.67 | 92 | 172849 | 69626 | 64256165 |
Hostility | 29.63 | 9.67 | 33 | 172908 | 2174 | 64323617 |
Osteoporosis | 29.34 | 9.67 | 42 | 172899 | 42038 | 64283753 |
Depressive symptom | 29.01 | 9.67 | 47 | 172894 | 4449 | 64321342 |
Erectile dysfunction | 28.97 | 9.67 | 87 | 172854 | 12540 | 64313251 |
Generalised tonic-clonic seizure | 28.56 | 9.67 | 194 | 172747 | 39663 | 64286128 |
Renal failure | 28.31 | 9.67 | 331 | 172610 | 181357 | 64144434 |
Arthritis | 28.23 | 9.67 | 122 | 172819 | 83692 | 64242099 |
Nasopharyngitis | 27.99 | 9.67 | 364 | 172577 | 195709 | 64130082 |
Obsessive-compulsive disorder | 27.92 | 9.67 | 48 | 172893 | 4770 | 64321021 |
Red blood cell sedimentation rate abnormal | 27.88 | 9.67 | 5 | 172936 | 16301 | 64309490 |
Lower respiratory tract infection viral | 27.88 | 9.67 | 22 | 172919 | 933 | 64324858 |
Drug resistance | 27.61 | 9.67 | 32 | 172909 | 35070 | 64290721 |
Legal problem | 27.44 | 9.67 | 12 | 172929 | 162 | 64325629 |
Cogwheel rigidity | 27.41 | 9.67 | 36 | 172905 | 2817 | 64322974 |
Poor quality sleep | 27.34 | 9.67 | 112 | 172829 | 18839 | 64306952 |
Head injury | 27.32 | 9.67 | 166 | 172775 | 32676 | 64293115 |
Miosis | 27.29 | 9.67 | 88 | 172853 | 13178 | 64312613 |
Pulmonary embolism | 27.16 | 9.67 | 547 | 172394 | 145809 | 64179982 |
Feeling jittery | 27.02 | 9.67 | 76 | 172865 | 10559 | 64315232 |
Skin ulcer | 26.78 | 9.67 | 48 | 172893 | 43926 | 64281865 |
Pruritus | 26.61 | 9.67 | 636 | 172305 | 311764 | 64014027 |
Behaviour disorder | 26.58 | 9.67 | 45 | 172896 | 4417 | 64321374 |
Bronchopulmonary aspergillosis | 26.54 | 9.67 | 9 | 172932 | 19076 | 64306715 |
Gestational diabetes | 26.44 | 9.67 | 51 | 172890 | 5539 | 64320252 |
Alcohol abuse | 26.38 | 9.67 | 47 | 172894 | 4805 | 64320986 |
Affective disorder | 26.33 | 9.67 | 56 | 172885 | 6524 | 64319267 |
Feeling guilty | 26.29 | 9.67 | 20 | 172921 | 803 | 64324988 |
Morose | 26.22 | 9.67 | 8 | 172933 | 34 | 64325757 |
Persecutory delusion | 26.20 | 9.67 | 43 | 172898 | 4115 | 64321676 |
Disease progression | 26.18 | 9.67 | 248 | 172693 | 141432 | 64184359 |
Syncope | 25.96 | 9.67 | 579 | 172362 | 157056 | 64168735 |
Electrocardiogram QT interval | 25.94 | 9.67 | 11 | 172930 | 137 | 64325654 |
Disinhibition | 25.85 | 9.67 | 31 | 172910 | 2212 | 64323579 |
Platelet aggregation inhibition | 25.73 | 9.67 | 11 | 172930 | 140 | 64325651 |
Stiff person syndrome | 25.64 | 9.67 | 13 | 172928 | 249 | 64325542 |
Feeling of despair | 25.60 | 9.67 | 33 | 172908 | 2535 | 64323256 |
White blood cell count decreased | 25.58 | 9.67 | 285 | 172656 | 157552 | 64168239 |
Restless legs syndrome | 25.37 | 9.67 | 102 | 172839 | 17014 | 64308777 |
Thermohypoaesthesia | 25.36 | 9.67 | 10 | 172931 | 102 | 64325689 |
Catatonia | 25.07 | 9.67 | 60 | 172881 | 7560 | 64318231 |
Sinusitis | 25.06 | 9.67 | 260 | 172681 | 145668 | 64180123 |
Haemophagocytic lymphohistiocytosis | 25.02 | 9.67 | 8 | 172933 | 17601 | 64308190 |
Mood swings | 25.02 | 9.67 | 103 | 172838 | 17365 | 64308426 |
Sepsis neonatal | 24.85 | 9.67 | 8 | 172933 | 42 | 64325749 |
Moaning | 24.61 | 9.67 | 21 | 172920 | 995 | 64324796 |
Sight disability | 24.53 | 9.67 | 10 | 172931 | 112 | 64325679 |
Epilepsy | 24.50 | 9.67 | 164 | 172777 | 33367 | 64292424 |
Somnambulism | 24.44 | 9.67 | 47 | 172894 | 5094 | 64320697 |
Bradykinesia | 24.16 | 9.67 | 54 | 172887 | 6506 | 64319285 |
Mite allergy | 24.05 | 9.67 | 18 | 172923 | 705 | 64325086 |
Haemoglobin decreased | 24.00 | 9.67 | 373 | 172568 | 194690 | 64131101 |
Initial insomnia | 23.92 | 9.67 | 50 | 172891 | 5754 | 64320037 |
Respiratory arrest | 23.87 | 9.67 | 232 | 172709 | 52753 | 64273038 |
Bundle branch block left | 23.84 | 9.67 | 70 | 172871 | 9964 | 64315827 |
Poisoning | 23.84 | 9.67 | 119 | 172822 | 21760 | 64304031 |
Learning disorder | 23.73 | 9.67 | 16 | 172925 | 530 | 64325261 |
Pyramidal tract syndrome | 23.67 | 9.67 | 16 | 172925 | 532 | 64325259 |
Bradycardia | 23.67 | 9.67 | 447 | 172494 | 117772 | 64208019 |
Judgement impaired | 23.62 | 9.67 | 21 | 172920 | 1052 | 64324739 |
Dysgraphia | 23.38 | 9.67 | 37 | 172904 | 3434 | 64322357 |
Tachycardia | 23.26 | 9.67 | 545 | 172396 | 149034 | 64176757 |
Dysphoria | 23.21 | 9.67 | 42 | 172899 | 4346 | 64321445 |
Angle closure glaucoma | 23.20 | 9.67 | 32 | 172909 | 2625 | 64323166 |
Maternal exposure during pregnancy | 23.19 | 9.67 | 156 | 172785 | 95728 | 64230063 |
Weight increased | 23.14 | 9.67 | 742 | 172199 | 212606 | 64113185 |
Knee arthroplasty | 23.03 | 9.67 | 23 | 172918 | 26976 | 64298815 |
Product use issue | 23.01 | 9.67 | 278 | 172663 | 151437 | 64174354 |
Device dislocation | 22.95 | 9.67 | 115 | 172826 | 21063 | 64304728 |
Mental status changes | 22.93 | 9.67 | 258 | 172683 | 60904 | 64264887 |
Neuropathy peripheral | 22.89 | 9.67 | 203 | 172738 | 117322 | 64208469 |
Transplant rejection | 22.85 | 9.67 | 9 | 172932 | 17392 | 64308399 |
Cardiac failure congestive | 22.69 | 9.67 | 232 | 172709 | 130348 | 64195443 |
Postictal state | 22.68 | 9.67 | 25 | 172916 | 1628 | 64324163 |
Nervousness | 22.47 | 9.67 | 146 | 172795 | 29410 | 64296381 |
Orthostatic hypotension | 22.22 | 9.67 | 207 | 172734 | 46531 | 64279260 |
Cough | 21.80 | 9.67 | 630 | 172311 | 301518 | 64024273 |
Ejaculation failure | 21.74 | 9.67 | 13 | 172928 | 348 | 64325443 |
Erythema | 21.59 | 9.67 | 362 | 172579 | 186708 | 64139083 |
Blood prolactin increased | 21.58 | 9.67 | 36 | 172905 | 3492 | 64322299 |
Uterine perforation | 21.54 | 9.67 | 48 | 172893 | 5772 | 64320019 |
Atrial fibrillation | 21.44 | 9.67 | 326 | 172615 | 170763 | 64155028 |
Self-injurious ideation | 21.42 | 9.67 | 34 | 172907 | 3163 | 64322628 |
Bronchial secretion retention | 21.41 | 9.67 | 30 | 172911 | 2497 | 64323294 |
Thinking abnormal | 21.41 | 9.67 | 74 | 172867 | 11482 | 64314309 |
Rheumatoid nodule | 21.37 | 9.67 | 4 | 172937 | 12647 | 64313144 |
Tearfulness | 21.33 | 9.67 | 42 | 172899 | 4631 | 64321160 |
Tumour lysis syndrome | 21.08 | 9.67 | 13 | 172928 | 19427 | 64306364 |
Middle insomnia | 20.92 | 9.67 | 79 | 172862 | 12798 | 64312993 |
Sinus tachycardia | 20.92 | 9.67 | 153 | 172788 | 32035 | 64293756 |
Irritable bowel syndrome | 20.83 | 9.67 | 43 | 172898 | 37326 | 64288465 |
Band sensation | 20.81 | 9.67 | 16 | 172925 | 653 | 64325138 |
Antiphospholipid antibodies | 20.74 | 9.67 | 9 | 172932 | 119 | 64325672 |
Tension | 20.63 | 9.67 | 37 | 172904 | 3803 | 64321988 |
Sleep-related eating disorder | 20.53 | 9.67 | 16 | 172925 | 666 | 64325125 |
Tubulointerstitial nephritis | 20.43 | 9.67 | 32 | 172909 | 30877 | 64294914 |
Anaphylactic shock | 20.43 | 9.67 | 31 | 172910 | 30297 | 64295494 |
Ascites | 20.42 | 9.67 | 91 | 172850 | 61910 | 64263881 |
Cellulitis | 20.41 | 9.67 | 157 | 172784 | 93500 | 64232291 |
Lip ulceration | 20.40 | 9.67 | 26 | 172915 | 1975 | 64323816 |
Heavy menstrual bleeding | 20.38 | 9.67 | 75 | 172866 | 12002 | 64313789 |
Hyperglycaemia | 20.38 | 9.67 | 89 | 172852 | 60879 | 64264912 |
Victim of sexual abuse | 20.30 | 9.67 | 13 | 172928 | 394 | 64325397 |
Conversion disorder | 20.21 | 9.67 | 24 | 172917 | 1695 | 64324096 |
Pain | 20.21 | 9.67 | 1247 | 171694 | 552264 | 63773527 |
Foetal exposure during pregnancy | 20.16 | 9.67 | 40 | 172901 | 4436 | 64321355 |
Dystonia | 20.13 | 9.67 | 102 | 172839 | 18763 | 64307028 |
Mental impairment | 20.06 | 9.67 | 92 | 172849 | 16251 | 64309540 |
Slow speech | 20.03 | 9.67 | 26 | 172915 | 2011 | 64323780 |
Delirium | 19.98 | 9.67 | 278 | 172663 | 68916 | 64256875 |
Headache | 19.93 | 9.67 | 1663 | 171278 | 527804 | 63797987 |
Gambling disorder | 19.93 | 9.67 | 25 | 172916 | 1869 | 64323922 |
Respiratory failure | 19.89 | 9.67 | 308 | 172633 | 160875 | 64164916 |
Post-traumatic neck syndrome | 19.84 | 9.67 | 25 | 172916 | 1877 | 64323914 |
Bipolar I disorder | 19.64 | 9.67 | 24 | 172917 | 1747 | 64324044 |
Device expulsion | 19.63 | 9.67 | 110 | 172831 | 21026 | 64304765 |
Migraine | 19.40 | 9.67 | 255 | 172686 | 62422 | 64263369 |
Treatment noncompliance | 19.40 | 9.67 | 190 | 172751 | 43292 | 64282499 |
Hypertension | 19.35 | 9.67 | 538 | 172403 | 258723 | 64067068 |
Chest injury | 19.32 | 9.67 | 28 | 172913 | 2405 | 64323386 |
Reduced facial expression | 19.28 | 9.67 | 26 | 172915 | 2087 | 64323704 |
Logorrhoea | 19.16 | 9.67 | 37 | 172904 | 4022 | 64321769 |
Family stress | 19.01 | 9.67 | 15 | 172926 | 636 | 64325155 |
Bone erosion | 18.89 | 9.67 | 4 | 172937 | 11591 | 64314200 |
Carcinoid syndrome | 18.82 | 9.67 | 9 | 172932 | 151 | 64325640 |
Hypervigilance | 18.80 | 9.67 | 13 | 172928 | 449 | 64325342 |
Fear | 18.75 | 9.67 | 105 | 172836 | 20066 | 64305725 |
Immobilisation prolonged | 18.70 | 9.67 | 8 | 172933 | 102 | 64325689 |
Euphoric mood | 18.65 | 9.67 | 49 | 172892 | 6542 | 64319249 |
Self-medication | 18.62 | 9.67 | 37 | 172904 | 4108 | 64321683 |
Acute myeloid leukaemia | 18.57 | 9.67 | 28 | 172913 | 27435 | 64298356 |
Conjunctivitis allergic | 18.50 | 9.67 | 18 | 172923 | 1012 | 64324779 |
Biliary dyskinesia | 18.40 | 9.67 | 27 | 172914 | 2345 | 64323446 |
Graft versus host disease | 18.38 | 9.67 | 7 | 172934 | 13806 | 64311985 |
Gynaecomastia | 18.34 | 9.67 | 46 | 172895 | 5970 | 64319821 |
Nausea | 18.32 | 9.67 | 2389 | 170552 | 783411 | 63542380 |
Painful respiration | 18.26 | 9.67 | 31 | 172910 | 3050 | 64322741 |
Breast swelling | 18.24 | 9.67 | 18 | 172923 | 1030 | 64324761 |
Red blood cell sedimentation rate increased | 18.22 | 9.67 | 35 | 172906 | 31200 | 64294591 |
Tongue biting | 18.15 | 9.67 | 23 | 172918 | 1737 | 64324054 |
Retroplacental haematoma | 18.03 | 9.67 | 8 | 172933 | 112 | 64325679 |
Dry mouth | 17.96 | 9.67 | 244 | 172697 | 60174 | 64265617 |
Illness anxiety disorder | 17.77 | 9.67 | 10 | 172931 | 238 | 64325553 |
Drug withdrawal syndrome neonatal | 17.62 | 9.67 | 10 | 172931 | 242 | 64325549 |
Personality disorder | 17.60 | 9.67 | 39 | 172902 | 4672 | 64321119 |
Head banging | 17.60 | 9.67 | 13 | 172928 | 499 | 64325292 |
Hepatotoxicity | 17.56 | 9.67 | 52 | 172889 | 39910 | 64285881 |
Intermenstrual bleeding | 17.56 | 9.67 | 41 | 172900 | 5084 | 64320707 |
Leukopenia | 17.53 | 9.67 | 180 | 172761 | 101062 | 64224729 |
Parkinsonian gait | 17.48 | 9.67 | 16 | 172925 | 833 | 64324958 |
Obsessive-compulsive personality disorder | 17.42 | 9.67 | 8 | 172933 | 122 | 64325669 |
Injury | 17.42 | 9.67 | 228 | 172713 | 55764 | 64270027 |
Hip arthroplasty | 17.30 | 9.67 | 19 | 172922 | 21332 | 64304459 |
Nephropathy toxic | 17.27 | 9.67 | 13 | 172928 | 17501 | 64308290 |
Torticollis | 17.20 | 9.67 | 25 | 172916 | 2152 | 64323639 |
Mycotic allergy | 17.11 | 9.67 | 17 | 172924 | 981 | 64324810 |
Palmar-plantar erythrodysaesthesia syndrome | 17.07 | 9.67 | 32 | 172909 | 28787 | 64297004 |
Barotrauma | 17.01 | 9.67 | 9 | 172932 | 189 | 64325602 |
Colitis microscopic | 16.86 | 9.67 | 51 | 172890 | 7381 | 64318410 |
Obsessive thoughts | 16.84 | 9.67 | 17 | 172924 | 1000 | 64324791 |
Ill-defined disorder | 16.82 | 9.67 | 61 | 172880 | 43991 | 64281800 |
Skin dystrophy | 16.71 | 9.67 | 6 | 172935 | 46 | 64325745 |
Deep vein thrombosis | 16.58 | 9.67 | 384 | 172557 | 104798 | 64220993 |
Suspected suicide | 16.55 | 9.67 | 56 | 172885 | 8598 | 64317193 |
Grandiosity | 16.46 | 9.67 | 13 | 172928 | 552 | 64325239 |
Enthesopathy | 16.38 | 9.67 | 3 | 172938 | 9635 | 64316156 |
Dust allergy | 16.34 | 9.67 | 17 | 172924 | 1036 | 64324755 |
Decreased interest | 16.32 | 9.67 | 31 | 172910 | 3329 | 64322462 |
Male orgasmic disorder | 16.28 | 9.67 | 6 | 172935 | 50 | 64325741 |
Trunk injury | 16.25 | 9.67 | 5 | 172936 | 22 | 64325769 |
Pleural effusion | 16.24 | 9.67 | 240 | 172701 | 126319 | 64199472 |
Speech disorder | 16.23 | 9.67 | 200 | 172741 | 48241 | 64277550 |
Enterocolitis | 16.14 | 9.67 | 6 | 172935 | 12012 | 64313779 |
Neoplasm progression | 16.12 | 9.67 | 56 | 172885 | 40908 | 64284883 |
Kidney transplant rejection | 16.08 | 9.67 | 3 | 172938 | 9508 | 64316283 |
Colitis | 15.98 | 9.67 | 92 | 172849 | 58582 | 64267209 |
Pneumonitis | 15.95 | 9.67 | 75 | 172866 | 50290 | 64275501 |
Bundle branch block right | 15.86 | 9.67 | 62 | 172879 | 10207 | 64315584 |
Large intestine anastomosis | 15.84 | 9.67 | 7 | 172934 | 97 | 64325694 |
Partner stress | 15.83 | 9.67 | 10 | 172931 | 296 | 64325495 |
Cerebral thrombosis | 15.73 | 9.67 | 24 | 172917 | 2158 | 64323633 |
Hemianopia | 15.69 | 9.67 | 20 | 172921 | 1519 | 64324272 |
Retrograde amnesia | 15.66 | 9.67 | 12 | 172929 | 487 | 64325304 |
Freezing phenomenon | 15.62 | 9.67 | 20 | 172921 | 1526 | 64324265 |
Road traffic accident | 15.55 | 9.67 | 138 | 172803 | 30607 | 64295184 |
Epstein-Barr virus infection | 15.53 | 9.67 | 7 | 172934 | 12481 | 64313310 |
Ocular hypertension | 15.48 | 9.67 | 18 | 172923 | 1243 | 64324548 |
Coma scale abnormal | 15.48 | 9.67 | 51 | 172890 | 7723 | 64318068 |
Rectal ulcer | 15.47 | 9.67 | 22 | 172919 | 1857 | 64323934 |
Left ventricle outflow tract obstruction | 15.44 | 9.67 | 10 | 172931 | 309 | 64325482 |
Neuromyelitis optica spectrum disorder | 15.44 | 9.67 | 15 | 172926 | 842 | 64324949 |
Gallbladder disorder | 15.40 | 9.67 | 88 | 172853 | 16942 | 64308849 |
Soft tissue injury | 15.29 | 9.67 | 20 | 172921 | 1559 | 64324232 |
Schizoaffective disorder | 15.21 | 9.67 | 20 | 172921 | 1567 | 64324224 |
Inappropriate affect | 15.17 | 9.67 | 18 | 172923 | 1270 | 64324521 |
Drug screen false positive | 15.10 | 9.67 | 16 | 172925 | 996 | 64324795 |
Sleep talking | 15.06 | 9.67 | 16 | 172925 | 999 | 64324792 |
Anterograde amnesia | 15.04 | 9.67 | 13 | 172928 | 627 | 64325164 |
Reactive psychosis | 15.01 | 9.67 | 4 | 172937 | 9 | 64325782 |
Angina pectoris | 14.95 | 9.67 | 66 | 172875 | 45015 | 64280776 |
Cerebellar syndrome | 14.92 | 9.67 | 38 | 172903 | 4978 | 64320813 |
Postural orthostatic tachycardia syndrome | 14.90 | 9.67 | 12 | 172929 | 524 | 64325267 |
Neurotoxicity | 14.88 | 9.67 | 32 | 172909 | 27372 | 64298419 |
Imprisonment | 14.87 | 9.67 | 12 | 172929 | 526 | 64325265 |
Brain stem haematoma | 14.72 | 9.67 | 7 | 172934 | 116 | 64325675 |
Compulsions | 14.70 | 9.67 | 10 | 172931 | 336 | 64325455 |
Pneumonia fungal | 14.59 | 9.67 | 3 | 172938 | 8874 | 64316917 |
Psychomotor skills impaired | 14.56 | 9.67 | 32 | 172909 | 3813 | 64321978 |
Spinal cord oedema | 14.50 | 9.67 | 10 | 172931 | 344 | 64325447 |
Hypophosphataemia | 14.42 | 9.67 | 11 | 172930 | 14709 | 64311082 |
Focal dyscognitive seizures | 14.34 | 9.67 | 29 | 172912 | 3261 | 64322530 |
Urinary retention | 14.33 | 9.67 | 198 | 172743 | 49003 | 64276788 |
Coronary artery disease | 14.27 | 9.67 | 99 | 172842 | 60334 | 64265457 |
Caesarean section | 14.24 | 9.67 | 64 | 172877 | 11210 | 64314581 |
Haemoglobin urine | 14.20 | 9.67 | 7 | 172934 | 126 | 64325665 |
Foot deformity | 14.14 | 9.67 | 14 | 172927 | 16490 | 64309301 |
Diarrhoea | 14.10 | 9.67 | 1710 | 171231 | 720994 | 63604797 |
Autonomic nervous system imbalance | 14.10 | 9.67 | 33 | 172908 | 4099 | 64321692 |
Hepatitis infectious mononucleosis | 14.10 | 9.67 | 7 | 172934 | 128 | 64325663 |
Ovarian vein thrombosis | 14.08 | 9.67 | 5 | 172936 | 37 | 64325754 |
Hydrops foetalis | 14.06 | 9.67 | 6 | 172935 | 76 | 64325715 |
Osteonecrosis of jaw | 14.01 | 9.67 | 57 | 172884 | 39768 | 64286023 |
Gastrointestinal haemorrhage | 13.99 | 9.67 | 260 | 172681 | 132052 | 64193739 |
Intraventricular haemorrhage | 13.99 | 9.67 | 33 | 172908 | 4120 | 64321671 |
Hyperphagia | 13.96 | 9.67 | 23 | 172918 | 2208 | 64323583 |
Myositis | 13.91 | 9.67 | 14 | 172927 | 16363 | 64309428 |
Hypokinesia | 13.87 | 9.67 | 84 | 172857 | 16512 | 64309279 |
Flight of ideas | 13.86 | 9.67 | 13 | 172928 | 698 | 64325093 |
Electrocardiogram QT interval abnormal | 13.85 | 9.67 | 9 | 172932 | 280 | 64325511 |
Apnoea | 13.80 | 9.67 | 60 | 172881 | 10362 | 64315429 |
Delusion of grandeur | 13.72 | 9.67 | 12 | 172929 | 588 | 64325203 |
Product substitution error | 13.64 | 9.67 | 5 | 172936 | 41 | 64325750 |
Sputum culture positive | 13.58 | 9.67 | 27 | 172914 | 2999 | 64322792 |
Dysarthria | 13.43 | 9.67 | 229 | 172712 | 59177 | 64266614 |
Extradural haematoma | 13.38 | 9.67 | 25 | 172916 | 2651 | 64323140 |
Musculoskeletal stiffness | 13.37 | 9.67 | 241 | 172700 | 122965 | 64202826 |
Device related infection | 13.35 | 9.67 | 40 | 172901 | 30586 | 64295205 |
Cardio-respiratory arrest | 13.35 | 9.67 | 352 | 172589 | 98041 | 64227750 |
Device placement issue | 13.33 | 9.67 | 13 | 172928 | 733 | 64325058 |
Abortion spontaneous | 13.31 | 9.67 | 114 | 172827 | 25029 | 64300762 |
Belligerence | 13.27 | 9.67 | 9 | 172932 | 301 | 64325490 |
Neoplasm malignant | 13.27 | 9.67 | 29 | 172912 | 24659 | 64301132 |
Psychiatric symptom | 13.26 | 9.67 | 42 | 172899 | 6231 | 64319560 |
Drug use disorder | 13.22 | 9.67 | 41 | 172900 | 6013 | 64319778 |
Ventricular dyskinesia | 13.22 | 9.67 | 10 | 172931 | 398 | 64325393 |
Peripheral sensory neuropathy | 13.21 | 9.67 | 7 | 172934 | 11371 | 64314420 |
Metabolic acidosis | 13.19 | 9.67 | 124 | 172817 | 70834 | 64254957 |
Drug eruption | 13.17 | 9.67 | 51 | 172890 | 36085 | 64289706 |
Concussion | 13.15 | 9.67 | 49 | 172892 | 7889 | 64317902 |
Respiratory disorder | 13.14 | 9.67 | 51 | 172890 | 36060 | 64289731 |
Electrocardiogram abnormal | 13.08 | 9.67 | 71 | 172870 | 13410 | 64312381 |
Pulmonary fibrosis | 13.04 | 9.67 | 39 | 172902 | 29839 | 64295952 |
Lethargy | 13.02 | 9.67 | 270 | 172671 | 72324 | 64253467 |
Cytotoxic oedema | 12.96 | 9.67 | 9 | 172932 | 313 | 64325478 |
Compulsive shopping | 12.89 | 9.67 | 13 | 172928 | 764 | 64325027 |
Atrial flutter | 12.87 | 9.67 | 20 | 172921 | 19360 | 64306431 |
Total lung capacity abnormal | 12.85 | 9.67 | 7 | 172934 | 156 | 64325635 |
Hyperventilation | 12.85 | 9.67 | 44 | 172897 | 6796 | 64318995 |
Menometrorrhagia | 12.80 | 9.67 | 12 | 172929 | 644 | 64325147 |
Cardiogenic shock | 12.70 | 9.67 | 138 | 172803 | 32289 | 64293502 |
Muscle necrosis | 12.64 | 9.67 | 16 | 172925 | 1207 | 64324584 |
Creatinine renal clearance decreased | 12.63 | 9.67 | 12 | 172929 | 14409 | 64311382 |
Hypermetropia | 12.61 | 9.67 | 10 | 172931 | 427 | 64325364 |
Bacteraemia | 12.58 | 9.67 | 34 | 172907 | 26877 | 64298914 |
Impaired driving ability | 12.56 | 9.67 | 34 | 172907 | 4620 | 64321171 |
Osteoarthritis | 12.50 | 9.67 | 109 | 172832 | 63227 | 64262564 |
Vertigo | 12.46 | 9.67 | 225 | 172716 | 58786 | 64267005 |
Alcohol poisoning | 12.41 | 9.67 | 32 | 172909 | 4223 | 64321568 |
Inhibitory drug interaction | 12.41 | 9.67 | 29 | 172912 | 3598 | 64322193 |
Pelvic pain | 12.36 | 9.67 | 60 | 172881 | 10850 | 64314941 |
Ileus | 12.32 | 9.67 | 27 | 172914 | 22939 | 64302852 |
Basal cell carcinoma | 12.24 | 9.67 | 42 | 172899 | 30796 | 64294995 |
Arthritis bacterial | 12.18 | 9.67 | 3 | 172938 | 7836 | 64317955 |
Bile acid malabsorption | 12.17 | 9.67 | 7 | 172934 | 174 | 64325617 |
Superior sagittal sinus thrombosis | 12.10 | 9.67 | 14 | 172927 | 962 | 64324829 |
Electroencephalogram abnormal | 12.08 | 9.67 | 36 | 172905 | 5167 | 64320624 |
Aphasia | 12.07 | 9.67 | 165 | 172776 | 40741 | 64285050 |
Attention-seeking behaviour | 12.07 | 9.67 | 6 | 172935 | 110 | 64325681 |
Joint hyperextension | 12.05 | 9.67 | 8 | 172933 | 258 | 64325533 |
Fibromyalgia | 12.04 | 9.67 | 52 | 172889 | 35679 | 64290112 |
Retching | 11.99 | 9.67 | 76 | 172865 | 15180 | 64310611 |
Pulmonary toxicity | 11.97 | 9.67 | 4 | 172937 | 8557 | 64317234 |
Hepatitis chronic active | 11.96 | 9.67 | 7 | 172934 | 180 | 64325611 |
Complication of device insertion | 11.94 | 9.67 | 35 | 172906 | 4977 | 64320814 |
Xerophthalmia | 11.86 | 9.67 | 10 | 172931 | 466 | 64325325 |
Retinal ischaemia | 11.86 | 9.67 | 12 | 172929 | 708 | 64325083 |
Sialoadenitis | 11.83 | 9.67 | 18 | 172923 | 1615 | 64324176 |
Extensor plantar response | 11.77 | 9.67 | 18 | 172923 | 1622 | 64324169 |
Priapism | 11.73 | 9.67 | 30 | 172911 | 3940 | 64321851 |
Unresponsive to stimuli | 11.66 | 9.67 | 195 | 172746 | 50198 | 64275593 |
Rash maculo-papular | 11.62 | 9.67 | 76 | 172865 | 46950 | 64278841 |
Sperm concentration decreased | 11.60 | 9.67 | 5 | 172936 | 65 | 64325726 |
Nephropathy | 11.58 | 9.67 | 4 | 172937 | 8382 | 64317409 |
Mood altered | 11.58 | 9.67 | 78 | 172863 | 15901 | 64309890 |
Laryngectomy | 11.58 | 9.67 | 4 | 172937 | 27 | 64325764 |
Hyperkalaemia | 11.56 | 9.67 | 196 | 172745 | 100933 | 64224858 |
Anti-actin antibody positive | 11.49 | 9.67 | 3 | 172938 | 6 | 64325785 |
Wound healing normal | 11.49 | 9.67 | 3 | 172938 | 6 | 64325785 |
Tinnitus | 11.47 | 9.67 | 141 | 172800 | 33992 | 64291799 |
Ejection fraction decreased | 11.46 | 9.67 | 39 | 172902 | 28668 | 64297123 |
Panic reaction | 11.46 | 9.67 | 30 | 172911 | 3997 | 64321794 |
Gambling | 11.45 | 9.67 | 8 | 172933 | 281 | 64325510 |
Stoma site discharge | 11.42 | 9.67 | 18 | 172923 | 1664 | 64324127 |
Hyperdynamic left ventricle | 11.40 | 9.67 | 8 | 172933 | 283 | 64325508 |
Psoriasis | 11.36 | 9.67 | 262 | 172679 | 71441 | 64254350 |
Female orgasmic disorder | 11.33 | 9.67 | 4 | 172937 | 29 | 64325762 |
Ejaculation disorder | 11.30 | 9.67 | 10 | 172931 | 498 | 64325293 |
Drug-induced liver injury | 11.27 | 9.67 | 78 | 172863 | 47565 | 64278226 |
General physical health deterioration | 11.26 | 9.67 | 441 | 172500 | 203984 | 64121807 |
Optic atrophy | 11.26 | 9.67 | 18 | 172923 | 1685 | 64324106 |
Endometrial disorder | 11.25 | 9.67 | 10 | 172931 | 501 | 64325290 |
Thrombotic microangiopathy | 11.24 | 9.67 | 17 | 172924 | 16638 | 64309153 |
Upper-airway cough syndrome | 11.24 | 9.67 | 50 | 172891 | 8720 | 64317071 |
Angina unstable | 11.22 | 9.67 | 15 | 172926 | 15452 | 64310339 |
Prescribed overdose | 11.19 | 9.67 | 93 | 172848 | 20238 | 64305553 |
Paraesthesia | 11.17 | 9.67 | 454 | 172487 | 134068 | 64191723 |
Yawning | 11.15 | 9.67 | 15 | 172926 | 1201 | 64324590 |
Diffuse large B-cell lymphoma | 11.13 | 9.67 | 7 | 172934 | 10354 | 64315437 |
Anaphylactic reaction | 11.11 | 9.67 | 124 | 172817 | 68540 | 64257251 |
Hot flush | 11.10 | 9.67 | 180 | 172761 | 46055 | 64279736 |
Product use in unapproved indication | 11.08 | 9.67 | 375 | 172566 | 176243 | 64149548 |
Mucormycosis | 11.04 | 9.67 | 3 | 172938 | 7338 | 64318453 |
Balance disorder | 11.02 | 9.67 | 299 | 172642 | 83627 | 64242164 |
Hypogammaglobulinaemia | 11.01 | 9.67 | 7 | 172934 | 10292 | 64315499 |
Burnout syndrome | 10.99 | 9.67 | 8 | 172933 | 300 | 64325491 |
Nephrotic syndrome | 10.94 | 9.67 | 6 | 172935 | 9561 | 64316230 |
Merycism | 10.91 | 9.67 | 7 | 172934 | 213 | 64325578 |
Carboxyhaemoglobin increased | 10.89 | 9.67 | 4 | 172937 | 33 | 64325758 |
Metastases to lung | 10.87 | 9.67 | 15 | 172926 | 15249 | 64310542 |
Intentional product use issue | 10.84 | 9.67 | 185 | 172756 | 95179 | 64230612 |
Musculoskeletal pain | 10.83 | 9.67 | 153 | 172788 | 81141 | 64244650 |
Pulmonary tuberculosis | 10.82 | 9.67 | 3 | 172938 | 7241 | 64318550 |
Cytokine release syndrome | 10.76 | 9.67 | 25 | 172916 | 20804 | 64304987 |
Creatinine urine decreased | 10.73 | 9.67 | 7 | 172934 | 219 | 64325572 |
Posterior reversible encephalopathy syndrome | 10.72 | 9.67 | 29 | 172912 | 22917 | 64302874 |
Nuchal rigidity | 10.68 | 9.67 | 13 | 172928 | 942 | 64324849 |
Cholangitis | 10.67 | 9.67 | 8 | 172933 | 10794 | 64314997 |
Cataract | 10.67 | 9.67 | 87 | 172854 | 51175 | 64274616 |
Cardiac arrest | 10.60 | 9.67 | 510 | 172431 | 153554 | 64172237 |
Delusional disorder, erotomanic type | 10.58 | 9.67 | 4 | 172937 | 36 | 64325755 |
Cognitive disorder | 10.58 | 9.67 | 207 | 172734 | 54880 | 64270911 |
Amenorrhoea | 10.53 | 9.67 | 40 | 172901 | 6499 | 64319292 |
Pseudomonas infection | 10.46 | 9.67 | 20 | 172921 | 17863 | 64307928 |
Liver disorder | 10.45 | 9.67 | 92 | 172849 | 53259 | 64272532 |
Hypercalcaemia | 10.41 | 9.67 | 46 | 172895 | 31370 | 64294421 |
Blood urea nitrogen/creatinine ratio decreased | 10.40 | 9.67 | 5 | 172936 | 85 | 64325706 |
Blood gases abnormal | 10.38 | 9.67 | 13 | 172928 | 970 | 64324821 |
Suture rupture | 10.34 | 9.67 | 10 | 172931 | 558 | 64325233 |
Lymphadenopathy | 10.29 | 9.67 | 78 | 172863 | 46608 | 64279183 |
Homicide | 10.26 | 9.67 | 14 | 172927 | 1137 | 64324654 |
Cytopenia | 10.24 | 9.67 | 16 | 172925 | 15455 | 64310336 |
Dissociation | 10.22 | 9.67 | 24 | 172917 | 2987 | 64322804 |
Staring | 10.21 | 9.67 | 21 | 172920 | 2389 | 64323402 |
Emotional poverty | 10.21 | 9.67 | 11 | 172930 | 698 | 64325093 |
Lung consolidation | 10.21 | 9.67 | 4 | 172937 | 7754 | 64318037 |
Dermatitis atopic | 10.14 | 9.67 | 28 | 172913 | 3848 | 64321943 |
Shoulder deformity | 10.13 | 9.67 | 4 | 172937 | 41 | 64325750 |
Flat affect | 10.11 | 9.67 | 18 | 172923 | 1839 | 64323952 |
Inflammatory marker increased | 10.11 | 9.67 | 5 | 172936 | 8446 | 64317345 |
Foreign body in reproductive tract | 10.10 | 9.67 | 9 | 172932 | 452 | 64325339 |
Drug dependence | 10.09 | 9.67 | 135 | 172806 | 33177 | 64292614 |
Oedema peripheral | 10.05 | 9.67 | 461 | 172480 | 209856 | 64115935 |
Sternal fracture | 10.02 | 9.67 | 20 | 172921 | 2227 | 64323564 |
Hypochloraemia | 9.99 | 9.67 | 19 | 172922 | 2042 | 64323749 |
Blood alcohol increased | 9.97 | 9.67 | 14 | 172927 | 1168 | 64324623 |
Cerebellar haematoma | 9.95 | 9.67 | 10 | 172931 | 585 | 64325206 |
Wheezing | 9.93 | 9.67 | 154 | 172787 | 80425 | 64245366 |
Lactic acidosis | 9.90 | 9.67 | 111 | 172830 | 61299 | 64264492 |
Polyarthritis | 9.85 | 9.67 | 7 | 172934 | 9708 | 64316083 |
Erection increased | 9.85 | 9.67 | 8 | 172933 | 354 | 64325437 |
Choroidal effusion | 9.71 | 9.67 | 10 | 172931 | 602 | 64325189 |
Polydipsia | 9.70 | 9.67 | 36 | 172905 | 5785 | 64320006 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Human herpesvirus 6 infection | 34.35 | 33.45 | 15 | 812 | 45 | 83806 |
Source | Code | Description |
---|---|---|
ATC | N06AB10 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Selective serotonin reuptake inhibitors |
FDA MoA | N0000000109 | Serotonin Uptake Inhibitors |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D018490 | Serotonin Agents |
MeSH PA | D017367 | Serotonin Uptake Inhibitors |
FDA EPC | N0000175696 | Serotonin Reuptake Inhibitor |
CHEBI has role | CHEBI:35469 | antidepressants |
CHEBI has role | CHEBI:76779 | post-proline endopeptidase inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Generalized anxiety disorder | indication | 21897009 | DOID:14320 |
Major depressive disorder | indication | 370143000 | |
Posttraumatic stress disorder | off-label use | 47505003 | DOID:2055 |
Bipolar affective disorder, current episode depression | off-label use | 191627008 | DOID:3312 |
Obsessive-compulsive disorder | off-label use | 191736004 | DOID:10933 |
Menopausal flushing | off-label use | 198436008 | |
Panic disorder | off-label use | 371631005 | DOID:594 |
Suicidal thoughts | contraindication | 6471006 | |
Bipolar disorder | contraindication | 13746004 | DOID:3312 |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Upper gastrointestinal hemorrhage | contraindication | 37372002 | |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Heart disease | contraindication | 56265001 | DOID:114 |
Acute nephropathy | contraindication | 58574008 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Hyponatremia | contraindication | 89627008 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Serotonin syndrome | contraindication | 371089000 | |
Myocardial infarction in recovery phase | contraindication | 418044006 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.33 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Ki | 8.96 | WOMBAT-PK | CHEMBL | |||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.19 | PDSP | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 5.60 | PDSP | |||||
Alpha-1A adrenergic receptor | GPCR | Ki | 5.41 | PDSP | |||||
Histamine H1 receptor | GPCR | Ki | 5.71 | PDSP | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 5.91 | PDSP | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 9.05 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 5.09 | CHEMBL | |||||
Transporter | Transporter | Ki | 4.98 | CHEMBL |
ID | Source |
---|---|
4024285 | VUID |
N0000022289 | NUI |
D02567 | KEGG_DRUG |
219861-08-2 | SECONDARY_CAS_RN |
4021356 | VANDF |
4024285 | VANDF |
C1099456 | UMLSCUI |
CHEBI:36791 | CHEBI |
68P | PDB_CHEM_ID |
CHEMBL1508 | ChEMBL_ID |
DB01175 | DRUGBANK_ID |
CHEMBL1200322 | ChEMBL_ID |
D000089983 | MESH_DESCRIPTOR_UI |
146570 | PUBCHEM_CID |
7177 | IUPHAR_LIGAND_ID |
7953 | INN_ID |
4O4S742ANY | UNII |
321988 | RXNORM |
158618 | MMSL |
16927 | MMSL |
187848 | MMSL |
d04812 | MMSL |
009709 | NDDF |
009710 | NDDF |
395246009 | SNOMEDCT_US |
400447003 | SNOMEDCT_US |
412384000 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Escitalopram Oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0852 | SOLUTION | 10 mg | ORAL | ANDA | 36 sections |
Lexapro | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-2005 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Lexapro | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-2005 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Lexapro | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-2010 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Lexapro | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-2010 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Lexapro | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-2020 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 32 sections |
Lexapro | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-2020 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 32 sections |
Lexapro | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-2101 | SOLUTION | 5 mg | ORAL | NDA | 32 sections |
Lexapro | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-2101 | SOLUTION | 5 mg | ORAL | NDA | 32 sections |
Escitalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7953 | TABLET | 5 mg | ORAL | ANDA | 31 sections |
Escitalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7954 | TABLET | 10 mg | ORAL | ANDA | 31 sections |
Escitalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7955 | TABLET | 20 mg | ORAL | ANDA | 31 sections |
Escitalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8348 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 31 sections |
Escitalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8349 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
Escitalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8350 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 31 sections |
Escitalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8365 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
Escitalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8366 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 31 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6426 | TABLET | 10 mg | ORAL | ANDA | 30 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6426 | TABLET | 10 mg | ORAL | ANDA | 30 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6427 | TABLET | 20 mg | ORAL | ANDA | 30 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6427 | TABLET | 20 mg | ORAL | ANDA | 30 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-224 | TABLET | 5 mg | ORAL | ANDA | 29 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-225 | TABLET | 10 mg | ORAL | ANDA | 29 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-230 | TABLET | 20 mg | ORAL | ANDA | 29 sections |
Escitalopram Oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-968 | TABLET, FILM COATED | 10 mg | ORAL | NDA authorized generic | 32 sections |
Escitalopram Oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-969 | TABLET, FILM COATED | 20 mg | ORAL | NDA authorized generic | 32 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-135 | TABLET | 5 mg | ORAL | ANDA | 28 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-135 | TABLET | 5 mg | ORAL | ANDA | 28 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-136 | TABLET | 10 mg | ORAL | ANDA | 28 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-136 | TABLET | 10 mg | ORAL | ANDA | 28 sections |