escitalopram Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1053 128196-01-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • escitalopram
  • (+)-(S)-Citalopram
  • (+)-Citalopram
  • (S)-Citalopram
  • S-(+)-Citalopram
  • seroplex
  • escitalopram oxalate
  • Molecular weight: 324.40
  • Formula: C20H21FN2O
  • CLOGP: 3.13
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 36.26
  • ALOGS: -4.74
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 8 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.88 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Aug. 14, 2002 FDA FOREST LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1951.42 30.74 607 7096 20427 2329955
Electrocardiogram QT prolonged 1192.77 30.74 333 7370 7481 2342901
Drug interaction 1158.88 30.74 448 7255 28715 2321667
Toxicity to various agents 1132.74 30.74 455 7248 32299 2318083
Hyponatraemia 1086.87 30.74 350 7353 12975 2337407
Suicide attempt 1004.74 30.74 317 7386 10965 2339417
Intentional overdose 966.26 30.74 308 7395 11013 2339369
Serotonin syndrome 878.61 30.74 222 7481 3318 2347064
Overdose 846.53 30.74 322 7381 19585 2330797
Suicidal ideation 772.93 30.74 259 7444 10828 2339554
Somnolence 757.02 30.74 311 7392 23174 2327208
Anxiety 664.67 30.74 303 7400 29056 2321326
Depression 657.86 30.74 297 7406 27835 2322547
Fall 605.96 30.74 331 7372 46768 2303614
Confusional state 578.20 30.74 260 7443 24084 2326298
Tremor 546.25 30.74 238 7465 20423 2329959
Seizure 520.12 30.74 242 7461 24224 2326158
Insomnia 480.55 30.74 233 7470 25554 2324828
Loss of consciousness 475.76 30.74 210 7493 18557 2331825
Dizziness 450.38 30.74 296 7407 58369 2292013
Inappropriate antidiuretic hormone secretion 447.00 30.74 119 7584 2190 2348192
Coma 443.86 30.74 163 7540 8893 2341489
Cardiac arrest 430.34 30.74 183 7520 14747 2335635
Agitation 412.29 30.74 163 7540 10888 2339494
Nausea 397.74 30.74 357 7346 111832 2238550
Product substitution issue 394.75 30.74 129 7574 4940 2345442
Sopor 390.94 30.74 121 7582 3874 2346508
Drug ineffective 357.00 30.74 322 7381 101302 2249080
Drug abuse 354.96 30.74 150 7553 11876 2338506
Condition aggravated 350.82 30.74 203 7500 31776 2318606
Hypotension 345.49 30.74 202 7501 32234 2318148
Headache 335.59 30.74 281 7422 79898 2270484
Intentional self-injury 333.31 30.74 108 7595 4019 2346363
Cardio-respiratory arrest 316.97 30.74 128 7575 9018 2341364
Depressed level of consciousness 289.81 30.74 114 7589 7490 2342892
Exposure during pregnancy 286.74 30.74 164 7539 25055 2325327
Torsade de pointes 275.44 30.74 81 7622 2165 2348217
Drug hypersensitivity 271.52 30.74 199 7504 46444 2303938
Hyperhidrosis 247.03 30.74 126 7577 15296 2335086
Pregnancy 243.86 30.74 102 7601 7847 2342535
Hypokalaemia 243.21 30.74 111 7592 10543 2339839
Vomiting 242.85 30.74 223 7480 71379 2279003
Respiratory arrest 240.20 30.74 94 7609 6084 2344298
Tachycardia 239.65 30.74 126 7577 16283 2334099
Bradycardia 224.69 30.74 103 7600 9878 2340504
Disturbance in attention 208.71 30.74 83 7620 5602 2344780
Fatigue 207.19 30.74 221 7482 84652 2265730
Syncope 205.77 30.74 115 7588 16760 2333622
Dyskinesia 204.40 30.74 78 7625 4711 2345671
Rhabdomyolysis 198.81 30.74 84 7619 6620 2343762
Mania 197.48 30.74 64 7639 2376 2348006
Aggression 197.27 30.74 76 7627 4710 2345672
Restlessness 197.19 30.74 75 7628 4488 2345894
Generalised tonic-clonic seizure 181.87 30.74 74 7629 5298 2345084
Irritability 178.88 30.74 77 7626 6350 2344032
Weight increased 178.41 30.74 116 7587 22221 2328161
Withdrawal syndrome 177.85 30.74 64 7639 3273 2347109
Caesarean section 172.45 30.74 66 7637 4015 2346367
Panic attack 170.83 30.74 65 7638 3891 2346491
Disorientation 169.68 30.74 74 7629 6298 2344084
Malaise 168.65 30.74 163 7540 55422 2294960
Orthostatic hypotension 167.76 30.74 59 7644 2820 2347562
Hyperreflexia 167.42 30.74 45 7658 856 2349526
Mydriasis 166.62 30.74 55 7648 2164 2348218
Foetal exposure during pregnancy 166.40 30.74 69 7634 5183 2345199
Muscle rigidity 164.48 30.74 52 7651 1779 2348603
Feeling abnormal 163.13 30.74 112 7591 23469 2326913
Poisoning deliberate 159.44 30.74 46 7657 1145 2349237
Sleep disorder 158.73 30.74 71 7632 6418 2343964
Asthenia 150.58 30.74 142 7561 46784 2303598
Drug withdrawal syndrome 145.95 30.74 68 7635 6753 2343629
Abnormal behaviour 145.61 30.74 61 7642 4699 2345683
Electrocardiogram QRS complex prolonged 145.01 30.74 42 7661 1060 2349322
Hepatitis 144.41 30.74 66 7637 6271 2344111
Maternal drugs affecting foetus 139.22 30.74 44 7659 1503 2348879
Decreased appetite 136.29 30.74 109 7594 28782 2321600
Sinus bradycardia 133.41 30.74 46 7657 2070 2348312
Amnesia 132.90 30.74 65 7638 7188 2343194
Sinus tachycardia 130.58 30.74 51 7652 3274 2347108
Crying 130.00 30.74 55 7648 4341 2346041
Akathisia 127.71 30.74 42 7661 1632 2348750
Palpitations 125.29 30.74 83 7620 16373 2334009
Arrhythmia 122.49 30.74 58 7645 5970 2344412
Galactorrhoea 121.27 30.74 38 7665 1261 2349121
Toxic epidermal necrolysis 119.16 30.74 47 7656 3097 2347285
Lethargy 118.71 30.74 64 7639 8666 2341716
Paraesthesia 118.58 30.74 90 7613 21998 2328384
Bundle branch block left 118.44 30.74 35 7668 949 2349433
Hypoglycaemia 118.15 30.74 63 7640 8344 2342038
Treatment noncompliance 117.84 30.74 55 7648 5479 2344903
Extrapyramidal disorder 117.52 30.74 43 7660 2304 2348078
Poisoning 116.93 30.74 45 7658 2775 2347607
Hyperthermia 116.70 30.74 38 7665 1430 2348952
Dystonia 116.58 30.74 42 7661 2152 2348230
Clonus 115.84 30.74 31 7672 579 2349803
Hallucination 114.34 30.74 61 7642 8087 2342295
Unresponsive to stimuli 111.75 30.74 51 7652 4825 2345557
Delirium 111.49 30.74 52 7651 5171 2345211
Intentional product misuse 111.01 30.74 63 7640 9426 2340956
Depressed mood 108.63 30.74 51 7652 5147 2345235
Myoclonus 107.89 30.74 41 7662 2442 2347940
Cardiogenic shock 107.76 30.74 41 7662 2450 2347932
Miosis 106.77 30.74 34 7669 1190 2349192
Haematoma 106.27 30.74 50 7653 5071 2345311
Urinary retention 105.49 30.74 45 7658 3622 2346760
Vertigo 100.95 30.74 59 7644 9325 2341057
Muscle twitching 100.12 30.74 40 7663 2725 2347657
Diarrhoea 100.08 30.74 153 7550 83411 2266971
Tinnitus 100.02 30.74 48 7655 5087 2345295
Off label use 99.98 30.74 143 7560 73455 2276927
Tardive dyskinesia 99.54 30.74 35 7668 1669 2348713
Reversible cerebral vasoconstriction syndrome 96.58 30.74 23 7680 261 2350121
Psychomotor hyperactivity 95.43 30.74 35 7668 1887 2348495
Balance disorder 91.14 30.74 56 7647 9691 2340691
Hallucination, visual 90.49 30.74 38 7665 2941 2347441
Mental status changes 90.35 30.74 46 7657 5536 2344846
Abdominal pain 89.61 30.74 93 7610 34281 2316101
Hypomagnesaemia 89.06 30.74 36 7667 2528 2347854
Pulseless electrical activity 87.72 30.74 28 7675 987 2349395
Bruxism 87.34 30.74 26 7677 723 2349659
Blood pressure increased 86.26 30.74 67 7636 16919 2333463
Dysarthria 85.09 30.74 46 7657 6256 2344126
Gamma-glutamyltransferase increased 84.71 30.74 44 7659 5518 2344864
Hepatocellular injury 82.30 30.74 39 7664 4016 2346366
Vision blurred 81.39 30.74 61 7642 14607 2335775
Thrombocytopenia 81.32 30.74 68 7635 19063 2331319
Parkinsonism 80.66 30.74 29 7674 1476 2348906
Sympathomimetic effect 79.77 30.74 13 7690 10 2350372
General physical health deterioration 78.89 30.74 59 7644 14080 2336302
Hypertension 76.68 30.74 77 7626 27284 2323098
Mental disorder 76.64 30.74 37 7666 3970 2346412
Sedation 76.50 30.74 35 7668 3327 2347055
Apathy 76.13 30.74 27 7676 1320 2349062
Alcohol use 75.26 30.74 21 7682 461 2349921
Major depression 74.92 30.74 25 7678 1016 2349366
Angle closure glaucoma 74.63 30.74 23 7680 721 2349661
Product use in unapproved indication 74.50 30.74 52 7651 11148 2339234
Maternal exposure during pregnancy 74.10 30.74 58 7645 14805 2335577
Cholestasis 73.11 30.74 35 7668 3686 2346696
Alanine aminotransferase increased 72.65 30.74 56 7647 13976 2336406
Loss of personal independence in daily activities 72.34 30.74 39 7664 5272 2345110
Muscle spasms 72.32 30.74 67 7636 21499 2328883
Altered state of consciousness 71.89 30.74 35 7668 3825 2346557
Premature baby 71.79 30.74 33 7670 3171 2347211
Delusion 71.73 30.74 29 7674 2036 2348346
Self-injurious ideation 71.63 30.74 21 7682 553 2349829
Epilepsy 71.51 30.74 37 7666 4602 2345780
Psychomotor retardation 71.31 30.74 21 7682 562 2349820
Dry mouth 71.04 30.74 45 7658 8208 2342174
Drug reaction with eosinophilia and systemic symptoms 70.94 30.74 39 7664 5479 2344903
Anaemia 69.66 30.74 82 7621 34710 2315672
Anger 69.57 30.74 30 7673 2477 2347905
Hypotonia 69.55 30.74 27 7676 1703 2348679
Aspartate aminotransferase increased 68.96 30.74 52 7651 12560 2337822
Sexual dysfunction 68.40 30.74 18 7685 314 2350068
International normalised ratio increased 68.19 30.74 42 7661 7294 2343088
Neuroleptic malignant syndrome 68.11 30.74 28 7675 2052 2348330
Affective disorder 67.49 30.74 22 7681 830 2349552
Circulatory collapse 67.09 30.74 33 7670 3687 2346695
Oculogyric crisis 67.06 30.74 18 7685 340 2350042
Thinking abnormal 66.52 30.74 27 7676 1915 2348467
Urinary incontinence 65.93 30.74 34 7669 4199 2346183
Muscular weakness 65.47 30.74 54 7649 14843 2335539
Colitis microscopic 65.46 30.74 22 7681 914 2349468
Suicidal behaviour 64.74 30.74 19 7684 502 2349880
Tongue biting 64.74 30.74 17 7686 294 2350088
Hypersomnia 64.63 30.74 28 7675 2338 2348044
Disease recurrence 63.39 30.74 31 7672 3420 2346962
Drug withdrawal syndrome neonatal 62.71 30.74 18 7685 439 2349943
Weight decreased 62.04 30.74 70 7633 28301 2322081
Bipolar disorder 61.74 30.74 23 7680 1295 2349087
Derealisation 61.46 30.74 15 7688 190 2350192
Human herpesvirus 6 infection 61.36 30.74 17 7686 363 2350019
Ventricular tachycardia 61.22 30.74 29 7674 2982 2347400
Heart rate increased 61.18 30.74 46 7657 11059 2339323
Aphasia 61.07 30.74 34 7669 4894 2345488
Paranoia 61.06 30.74 26 7677 2081 2348301
Hepatitis cholestatic 60.89 30.74 22 7681 1135 2349247
Speech disorder 60.05 30.74 37 7666 6427 2343955
Coordination abnormal 59.17 30.74 25 7678 1963 2348419
Acute kidney injury 59.14 30.74 68 7635 28054 2322328
Shock 59.03 30.74 31 7672 3973 2346409
Dyspnoea 58.56 30.74 117 7586 78616 2271766
Psychotic disorder 57.21 30.74 32 7671 4647 2345735
Respiratory depression 57.06 30.74 25 7678 2145 2348237
Optic nerve injury 57.01 30.74 13 7690 120 2350262
Ventricular fibrillation 56.72 30.74 25 7678 2176 2348206
Hypersensitivity 56.39 30.74 61 7642 23532 2326850
Hypertonia 55.92 30.74 21 7682 1209 2349173
Cognitive disorder 55.66 30.74 33 7670 5348 2345034
Melaena 55.49 30.74 30 7673 4076 2346306
Myalgia 55.19 30.74 60 7643 23273 2327109
Rectal ulcer 54.57 30.74 14 7689 220 2350162
Long QT syndrome 54.47 30.74 17 7686 556 2349826
Blood sodium decreased 54.41 30.74 27 7676 3073 2347309
Medication error 54.19 30.74 34 7669 6097 2344285
Cerebral haematoma 54.06 30.74 17 7686 570 2349812
Gestational diabetes 53.47 30.74 21 7682 1366 2349016
Subdural haematoma 53.04 30.74 24 7679 2222 2348160
Dehydration 52.15 30.74 57 7646 22238 2328144
Thermohypoaesthesia 51.92 30.74 9 7694 14 2350368
Mood altered 51.43 30.74 25 7678 2721 2347661
Hypoaesthesia 51.37 30.74 54 7649 20161 2330221
Ecchymosis 50.78 30.74 21 7682 1562 2348820
Initial insomnia 50.04 30.74 17 7686 730 2349652
Gait disturbance 49.91 30.74 56 7647 22489 2327893
Rash 49.73 30.74 93 7610 59465 2290917
Self-medication 49.61 30.74 16 7687 583 2349799
Ventricular extrasystoles 49.59 30.74 22 7681 1944 2348438
Sepsis neonatal 49.21 30.74 11 7692 92 2350290
Memory impairment 48.90 30.74 43 7660 12880 2337502
Alcoholism 48.63 30.74 14 7689 345 2350037
Logorrhoea 48.55 30.74 15 7688 474 2349908
Mental impairment 48.08 30.74 23 7680 2417 2347965
Impaired work ability 48.07 30.74 21 7682 1789 2348593
Prescribed overdose 47.91 30.74 21 7682 1803 2348579
Impaired driving ability 47.85 30.74 18 7685 1041 2349341
Atrial septal defect 47.11 30.74 19 7684 1325 2349057
Electrocardiogram abnormal 47.05 30.74 19 7684 1329 2349053
Foetal death 46.96 30.74 21 7682 1891 2348491
Extensor plantar response 46.68 30.74 13 7690 283 2350099
Conversion disorder 46.49 30.74 14 7689 405 2349977
Psychomotor skills impaired 46.39 30.74 14 7689 408 2349974
Pyrexia 46.25 30.74 85 7618 53623 2296759
Gun shot wound 45.82 30.74 10 7693 74 2350308
Abdominal pain upper 45.71 30.74 53 7650 22047 2328335
Atrioventricular block 45.42 30.74 18 7685 1199 2349183
Asphyxia 45.13 30.74 17 7686 987 2349395
Pre-eclampsia 45.04 30.74 19 7684 1485 2348897
Abnormal dreams 44.90 30.74 22 7681 2436 2347946
Haemorrhagic stroke 44.20 30.74 17 7686 1045 2349337
Obsessive-compulsive disorder 43.95 30.74 15 7688 653 2349729
Metrorrhagia 43.88 30.74 21 7682 2208 2348174
Muscle tightness 43.86 30.74 20 7683 1885 2348497
Road traffic accident 43.45 30.74 26 7677 4282 2346100
Sight disability 43.36 30.74 8 7695 21 2350361
Depressive symptom 42.94 30.74 14 7689 528 2349854
Vaginal haemorrhage 42.46 30.74 27 7676 4953 2345429
Left ventricle outflow tract obstruction 42.18 30.74 9 7694 59 2350323
Pemphigoid 41.87 30.74 16 7687 966 2349416
Status epilepticus 41.77 30.74 21 7682 2457 2347925
Mood swings 41.72 30.74 23 7680 3246 2347136
Acute respiratory distress syndrome 41.57 30.74 23 7680 3269 2347113
Panic reaction 41.55 30.74 15 7688 772 2349610
Pneumonia aspiration 41.46 30.74 24 7679 3718 2346664
Abdominal discomfort 41.46 30.74 45 7658 17411 2332971
Migraine 41.41 30.74 36 7667 10617 2339765
Bradykinesia 41.30 30.74 14 7689 597 2349785
Product dispensing error 41.27 30.74 21 7682 2520 2347862
Drug intolerance 40.97 30.74 40 7663 13677 2336705
Blood potassium decreased 40.90 30.74 27 7676 5278 2345104
Congenital pulmonary valve atresia 40.79 30.74 8 7695 32 2350350
Homicidal ideation 40.59 30.74 13 7690 463 2349919
Drug dependence 40.45 30.74 22 7681 3023 2347359
Bradyphrenia 40.12 30.74 16 7687 1083 2349299
Renal failure 39.94 30.74 44 7659 17305 2333077
Atrial tachycardia 39.72 30.74 12 7691 351 2350031
Platelet aggregation inhibition 39.60 30.74 7 7696 13 2350369
Cyanosis 39.53 30.74 22 7681 3163 2347219
Dysphagia 39.48 30.74 38 7665 12767 2337615
Libido decreased 39.19 30.74 13 7690 518 2349864
Discomfort 39.15 30.74 26 7677 5133 2345249
Nightmare 39.08 30.74 23 7680 3674 2346708
Nervousness 39.01 30.74 26 7677 5163 2345219
Premature labour 38.92 30.74 19 7684 2087 2348295
Axonal neuropathy 38.75 30.74 10 7693 161 2350221
Anhedonia 38.67 30.74 16 7687 1191 2349191
Stevens-Johnson syndrome 38.59 30.74 24 7679 4235 2346147
White blood cell count increased 38.26 30.74 29 7674 7049 2343333
Sluggishness 38.20 30.74 15 7688 975 2349407
Abortion spontaneous 37.91 30.74 38 7665 13407 2336975
Multimorbidity 37.71 30.74 9 7694 103 2350279
Cerebral haemorrhage 37.62 30.74 26 7677 5478 2344904
Bradypnoea 37.61 30.74 12 7691 422 2349960
Restless legs syndrome 37.56 30.74 19 7684 2252 2348130
Hypomania 37.49 30.74 14 7689 793 2349589
Extradural haematoma 37.36 30.74 11 7692 294 2350088
Product use issue 37.30 30.74 36 7667 12133 2338249
Pupillary reflex impaired 36.95 30.74 12 7691 447 2349935
Partner stress 36.92 30.74 8 7695 57 2350325
Muscle haemorrhage 36.83 30.74 13 7690 626 2349756
Gastrointestinal haemorrhage 36.64 30.74 36 7667 12399 2337983
Drug-induced liver injury 36.47 30.74 22 7681 3677 2346705
Abdominal wall haematoma 36.37 30.74 12 7691 470 2349912
Small for dates baby 36.29 30.74 13 7690 654 2349728
Death 36.21 30.74 99 7604 81369 2269013
Rectal haemorrhage 36.17 30.74 26 7677 5830 2344552
Hypertensive cardiomyopathy 36.10 30.74 8 7695 64 2350318
Nystagmus 35.96 30.74 15 7688 1140 2349242
Hemianopia 35.94 30.74 10 7693 217 2350165
Blood alkaline phosphatase increased 35.78 30.74 27 7676 6518 2343864
Euphoric mood 35.69 30.74 14 7689 907 2349475
Pancreatitis acute 35.64 30.74 22 7681 3831 2346551
Amaurosis 35.59 30.74 9 7694 133 2350249
Purpura 35.47 30.74 17 7686 1793 2348589
Bipolar I disorder 35.41 30.74 11 7692 354 2350028
Apallic syndrome 35.40 30.74 9 7694 136 2350246
Anuria 35.34 30.74 17 7686 1807 2348575
Torticollis 35.29 30.74 11 7692 358 2350024
Petit mal epilepsy 35.09 30.74 13 7690 720 2349662
Postictal state 34.98 30.74 10 7693 240 2350142
Toxic skin eruption 34.74 30.74 18 7685 2242 2348140
Visual impairment 34.58 30.74 34 7669 11721 2338661
Blindness 34.33 30.74 21 7682 3597 2346785
Skin burning sensation 34.22 30.74 17 7686 1939 2348443
Pruritus 34.06 30.74 66 7637 43274 2307108
Contusion 33.92 30.74 35 7668 12775 2337607
Drug level increased 33.90 30.74 19 7684 2768 2347614
Hot flush 33.51 30.74 27 7676 7172 2343210
Bundle branch block 33.23 30.74 9 7694 176 2350206
Therapeutic product effect decreased 33.22 30.74 32 7671 10757 2339625
Glaucoma 33.11 30.74 17 7686 2078 2348304
Affect lability 33.06 30.74 17 7686 2085 2348297
Pulmonary oedema 32.97 30.74 27 7676 7336 2343046
Pupil fixed 32.95 30.74 11 7692 447 2349935
Therapy non-responder 32.74 30.74 28 7675 8076 2342306
Hallucination, auditory 32.39 30.74 17 7686 2175 2348207
Head injury 32.24 30.74 21 7682 4013 2346369
Brain injury 32.24 30.74 13 7690 906 2349476
Drug screen positive 32.22 30.74 13 7690 907 2349475
Blood creatine phosphokinase increased 32.17 30.74 23 7680 5113 2345269
Stupor 32.15 30.74 12 7691 679 2349703
Blood gases abnormal 32.04 30.74 8 7695 112 2350270
Hepatitis acute 31.86 30.74 15 7688 1520 2348862
Alcohol poisoning 31.83 30.74 10 7693 334 2350048
Dysphoria 31.82 30.74 15 7688 1524 2348858
Hyperventilation 31.79 30.74 14 7689 1215 2349167
Anxiety disorder 31.69 30.74 11 7692 504 2349878
Atrioventricular block first degree 31.60 30.74 13 7690 954 2349428
Hyperleukocytosis 31.48 30.74 7 7696 57 2350325
Neuromyelitis optica spectrum disorder 31.45 30.74 9 7694 217 2350165

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1433.14 33.55 439 3749 15873 1726720
Serotonin syndrome 582.30 33.55 149 4039 2639 1739954
Toxicity to various agents 525.87 33.55 248 3940 28893 1713700
Intentional overdose 508.85 33.55 168 4020 7502 1735091
Suicide attempt 494.92 33.55 163 4025 7218 1735375
Drug interaction 492.09 33.55 234 3954 27724 1714869
Suicidal ideation 410.54 33.55 147 4041 8371 1734222
Foetal exposure during pregnancy 396.26 33.55 133 4055 6226 1736367
Anxiety 386.79 33.55 166 4022 15361 1727232
Electrocardiogram QT prolonged 373.43 33.55 123 4065 5422 1737171
Somnolence 352.28 33.55 159 4029 16580 1726013
Overdose 349.43 33.55 158 4030 16543 1726050
Agitation 342.12 33.55 138 4050 10888 1731705
Seizure 340.02 33.55 165 4023 20276 1722317
Depression 308.82 33.55 145 4043 16524 1726069
Tremor 279.92 33.55 126 4062 13005 1729588
Hyponatraemia 235.97 33.55 100 4088 8900 1733693
Aggression 235.70 33.55 97 4091 8018 1734575
Fall 228.92 33.55 140 4048 27074 1715519
Condition aggravated 228.47 33.55 128 4060 21022 1721571
Sopor 221.32 33.55 65 4123 1936 1740657
Intentional self-injury 202.77 33.55 65 4123 2608 1739985
Insomnia 199.04 33.55 107 4081 16169 1726424
Confusional state 198.24 33.55 117 4071 21161 1721432
Maternal drugs affecting foetus 188.36 33.55 51 4137 1120 1741473
Loss of consciousness 182.41 33.55 98 4090 14777 1727816
Coma 181.32 33.55 78 4110 7184 1735409
Hyperhidrosis 177.96 33.55 91 4097 12397 1730196
Mania 162.27 33.55 52 4136 2081 1740512
Sexual dysfunction 149.22 33.55 47 4141 1776 1740817
Restlessness 147.19 33.55 58 4130 4263 1738330
Drug ineffective 143.35 33.55 151 4037 63650 1678943
Bradycardia 142.02 33.55 74 4114 10460 1732133
Electrocardiogram QRS complex prolonged 139.96 33.55 37 4151 738 1741855
Drug abuse 139.78 33.55 80 4108 13609 1728984
Poisoning 134.07 33.55 47 4141 2485 1740108
Malaise 133.83 33.55 104 4084 29461 1713132
Urinary retention 128.20 33.55 56 4132 5339 1737254
Muscle rigidity 124.09 33.55 41 4147 1807 1740786
Dizziness 114.04 33.55 101 4087 34260 1708333
Tachycardia 113.55 33.55 68 4120 12560 1730033
Disorientation 108.34 33.55 50 4138 5419 1737174
Dyskinesia 105.09 33.55 44 4144 3775 1738818
Cardio-respiratory arrest 104.76 33.55 58 4130 9235 1733358
Vomiting 100.84 33.55 99 4089 38216 1704377
Torsade de pointes 99.51 33.55 32 4156 1292 1741301
Abnormal behaviour 98.32 33.55 49 4139 6293 1736300
Product substitution issue 97.64 33.55 40 4148 3246 1739347
Hallucination 97.62 33.55 53 4135 8117 1734476
Nausea 93.59 33.55 109 4079 51087 1691506
Withdrawal syndrome 93.18 33.55 35 4153 2253 1740340
Gun shot wound 92.14 33.55 23 4165 361 1742232
Small for dates baby 91.12 33.55 25 4163 576 1742017
Exposure during pregnancy 89.56 33.55 36 4152 2781 1739812
Drug withdrawal syndrome 88.45 33.55 41 4147 4484 1738109
Apathy 87.97 33.55 29 4159 1267 1741326
Rhabdomyolysis 87.60 33.55 55 4133 11035 1731558
Prescribed overdose 86.61 33.55 31 4157 1739 1740854
Hypotension 86.21 33.55 81 4107 29573 1713020
Feeling abnormal 84.75 33.55 54 4134 11112 1731481
Paranoia 83.88 33.55 32 4156 2149 1740444
Mydriasis 83.39 33.55 28 4160 1296 1741297
Erectile dysfunction 82.49 33.55 39 4149 4458 1738135
Panic attack 81.52 33.55 30 4158 1822 1740771
Weight increased 81.44 33.55 53 4135 11304 1731289
Sleep disorder 79.98 33.55 37 4151 4026 1738567
Disinhibition 79.53 33.55 20 4168 324 1742269
Disturbance in attention 78.52 33.55 37 4151 4197 1738396
Delirium 78.00 33.55 42 4146 6320 1736273
Cerebral haematoma 77.05 33.55 23 4165 722 1741871
Hallucination, visual 75.11 33.55 31 4157 2561 1740032
Irritability 74.83 33.55 39 4149 5493 1737100
Parkinsonism 74.68 33.55 26 4162 1343 1741250
Drug withdrawal syndrome neonatal 74.46 33.55 22 4166 666 1741927
Poisoning deliberate 74.27 33.55 23 4165 819 1741774
Hypospadias 73.58 33.55 21 4167 561 1742032
Amnesia 73.45 33.55 37 4151 4854 1737739
Headache 72.59 33.55 79 4109 34297 1708296
Neuroleptic malignant syndrome 72.53 33.55 32 4156 3116 1739477
Cardiac arrest 71.78 33.55 56 4132 15874 1726719
Libido decreased 71.65 33.55 25 4163 1300 1741293
Epilepsy 71.58 33.55 34 4154 3925 1738668
Abulia 70.57 33.55 15 4173 109 1742484
Myoclonus 68.37 33.55 28 4160 2267 1740326
Anencephaly 67.84 33.55 11 4177 10 1742583
Human herpesvirus 6 infection 67.58 33.55 18 4170 369 1742224
Agranulocytosis 65.53 33.55 31 4157 3545 1739048
Major depression 65.10 33.55 20 4168 693 1741900
Depressed mood 64.17 33.55 29 4159 2987 1739606
Gynaecomastia 63.47 33.55 26 4162 2106 1740487
Diarrhoea 62.85 33.55 92 4096 53760 1688833
Impulsive behaviour 62.18 33.55 18 4170 506 1742087
Hepatitis 61.53 33.55 33 4155 4922 1737671
Inappropriate antidiuretic hormone secretion 61.34 33.55 24 4164 1724 1740869
Hypomania 61.13 33.55 18 4170 538 1742055
Extrapyramidal disorder 60.74 33.55 26 4162 2351 1740242
Caesarean section 59.34 33.55 18 4170 597 1741996
Hyperthermia 58.57 33.55 23 4165 1668 1740925
Premature baby 58.53 33.55 27 4161 2915 1739678
Anhedonia 58.24 33.55 19 4169 802 1741791
Sedation 57.68 33.55 28 4160 3389 1739204
Muscle necrosis 57.56 33.55 14 4174 196 1742397
Mental disorder 56.28 33.55 26 4162 2817 1739776
Generalised tonic-clonic seizure 56.07 33.55 29 4159 4017 1738576
Homicide 55.88 33.55 15 4173 317 1742276
Activation syndrome 55.10 33.55 11 4177 56 1742537
Alcohol use 53.59 33.55 18 4170 833 1741760
Akathisia 52.91 33.55 20 4168 1308 1741285
Depressed level of consciousness 52.77 33.55 33 4155 6559 1736034
Decreased appetite 52.31 33.55 56 4132 23815 1718778
Treatment noncompliance 51.89 33.55 30 4158 5171 1737422
Bruxism 51.84 33.55 14 4174 303 1742290
Off label use 50.98 33.55 70 4118 38501 1704092
Hypomagnesaemia 50.50 33.55 22 4166 2076 1740517
Cardiogenic shock 50.32 33.55 23 4165 2431 1740162
Memory impairment 49.95 33.55 32 4156 6631 1735962
Fatigue 49.68 33.55 80 4108 50701 1691892
Hyperkalaemia 49.57 33.55 35 4153 8512 1734081
Asphyxia 49.34 33.55 18 4170 1065 1741528
Atrial septal defect 48.90 33.55 19 4169 1339 1741254
Hypokalaemia 48.74 33.55 31 4157 6343 1736250
Blood creatine phosphokinase increased 48.45 33.55 35 4153 8821 1733772
Body temperature increased 48.40 33.55 23 4165 2654 1739939
Speech disorder 47.42 33.55 27 4161 4521 1738072
Cholestasis 47.15 33.55 25 4163 3640 1738953
Legal problem 47.00 33.55 10 4178 73 1742520
Asthenia 45.91 33.55 63 4125 34607 1707986
Orthostatic hypotension 45.83 33.55 24 4164 3407 1739186
Self-medication 45.23 33.55 15 4173 667 1741926
Drug hypersensitivity 45.12 33.55 42 4146 15093 1727500
Hypertension 45.03 33.55 47 4141 19401 1723192
Psychotic disorder 44.77 33.55 27 4161 5029 1737564
Alcoholism 44.65 33.55 14 4174 519 1742074
Motor developmental delay 43.83 33.55 9 4179 54 1742539
Hypotonia 42.85 33.55 18 4170 1552 1741041
Hyperreflexia 42.55 33.55 14 4174 607 1741986
Physical assault 41.06 33.55 12 4176 349 1742244
Priapism 40.68 33.55 17 4171 1447 1741146
Sudden death 40.51 33.55 21 4167 2919 1739674
Tachyphrenia 40.43 33.55 11 4177 245 1742348
Sinus bradycardia 39.26 33.55 18 4170 1915 1740678
Road traffic accident 39.15 33.55 22 4166 3591 1739002
Dysgraphia 38.92 33.55 11 4177 283 1742310
Respiratory arrest 38.77 33.55 26 4162 5813 1736780
Pneumonia aspiration 38.74 33.55 25 4163 5241 1737352
Hepatocellular injury 38.65 33.55 21 4167 3210 1739383
Syncope 37.82 33.55 37 4151 14132 1728461
Bradypnoea 37.44 33.55 11 4177 326 1742267
Crying 37.23 33.55 16 4172 1459 1741134
Drug reaction with eosinophilia and systemic symptoms 37.12 33.55 24 4164 5046 1737547
Anger 36.61 33.55 19 4169 2647 1739946
Pelvic kidney 36.24 33.55 6 4182 7 1742586
Urinary incontinence 36.15 33.55 19 4169 2717 1739876
Hepatitis cholestatic 35.57 33.55 15 4173 1306 1741287
Ventricular tachycardia 35.48 33.55 21 4167 3777 1738816
Cognitive disorder 35.45 33.55 22 4166 4308 1738285
Selective eating disorder 35.02 33.55 11 4177 410 1742183
Neonatal respiratory distress syndrome 34.89 33.55 13 4175 816 1741777
Self esteem decreased 34.89 33.55 9 4179 162 1742431
International normalised ratio increased 34.80 33.55 28 4160 8271 1734322
Cerebral haemorrhage 34.76 33.55 25 4163 6252 1736341
Hallucination, auditory 34.67 33.55 17 4171 2100 1740493
Subdural haematoma 34.63 33.55 20 4168 3437 1739156
Hypothyroidism 34.45 33.55 18 4170 2542 1740051
Delusion 33.83 33.55 17 4171 2214 1740379
Clonus 33.79 33.55 11 4177 461 1742132
Abdominal pain upper 33.68 33.55 31 4157 10970 1731623
Exposure via ingestion 33.59 33.55 12 4176 668 1741925

Pharmacologic Action:

SourceCodeDescription
ATC N06AB10 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
FDA EPC N0000175696 Serotonin Reuptake Inhibitor
FDA MoA N0000000109 Serotonin Uptake Inhibitors
CHEBI has role CHEBI:35469 antidepressant

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Major depressive disorder indication 370143000
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Obsessive-compulsive disorder off-label use 191736004 DOID:10933
Menopausal flushing off-label use 198436008
Panic disorder off-label use 371631005 DOID:594
Suicidal thoughts contraindication 6471006
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Upper gastrointestinal hemorrhage contraindication 37372002
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Heart disease contraindication 56265001 DOID:114
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Epilepsy contraindication 84757009 DOID:1826
Hyponatremia contraindication 89627008
Disease of liver contraindication 235856003 DOID:409
Serotonin syndrome contraindication 371089000
Myocardial infarction in recovery phase contraindication 418044006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Ki 8.96 WOMBAT-PK CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 5.91 PDSP
Histamine H1 receptor GPCR Ki 5.71 PDSP
5-hydroxytryptamine receptor 2C GPCR Ki 5.60 PDSP
Alpha-1A adrenergic receptor GPCR Ki 5.41 PDSP
Sodium-dependent noradrenaline transporter Transporter Ki 5.19 PDSP
Transporter Transporter Ki 4.98 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 5.09 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 9.05 CHEMBL

External reference:

IDSource
4024285 VUID
N0000022289 NUI
C1099456 UMLSCUI
D02567 KEGG_DRUG
4O4S742ANY UNII
7953 INN_ID
219861-08-2 SECONDARY_CAS_RN
395246009 SNOMEDCT_US
321988 RXNORM
400447003 SNOMEDCT_US
d04812 MMSL
4024285 VANDF
009709 NDDF
158618 MMSL
CHEMBL1508 ChEMBL_ID
CHEMBL1200322 ChEMBL_ID
DB01175 DRUGBANK_ID
CHEBI:36791 CHEBI
146570 PUBCHEM_CID
7177 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0093-5850 TABLET, FILM COATED 5 mg ORAL ANDA 19 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0093-5851 TABLET, FILM COATED 10 mg ORAL ANDA 19 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0093-5852 TABLET, FILM COATED 20 mg ORAL ANDA 19 sections
Escitalopram Oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0121-0852 SOLUTION 10 mg ORAL ANDA 20 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2005 TABLET, FILM COATED 5 mg ORAL NDA 19 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2010 TABLET, FILM COATED 10 mg ORAL NDA 19 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2020 TABLET, FILM COATED 20 mg ORAL NDA 19 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2101 SOLUTION 5 mg ORAL NDA 19 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-7720 TABLET, FILM COATED 5 mg ORAL ANDA 19 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-7721 TABLET, FILM COATED 10 mg ORAL ANDA 19 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-7722 TABLET, FILM COATED 20 mg ORAL ANDA 19 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-7953 TABLET 5 mg ORAL ANDA 20 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-7954 TABLET 10 mg ORAL ANDA 20 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-7955 TABLET 20 mg ORAL ANDA 20 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6426 TABLET 10 mg ORAL ANDA 19 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6427 TABLET 20 mg ORAL ANDA 19 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 10544-224 TABLET 5 mg ORAL ANDA 19 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 10544-225 TABLET 10 mg ORAL ANDA 19 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 10544-230 TABLET 20 mg ORAL ANDA 19 sections
Escitalopram Oxalate HUMAN PRESCRIPTION DRUG LABEL 1 10544-968 TABLET, FILM COATED 10 mg ORAL NDA authorized generic 20 sections
Escitalopram Oxalate HUMAN PRESCRIPTION DRUG LABEL 1 10544-969 TABLET, FILM COATED 20 mg ORAL NDA authorized generic 20 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 13668-135 TABLET 5 mg ORAL ANDA 19 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 13668-136 TABLET 10 mg ORAL ANDA 19 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 13668-137 TABLET 20 mg ORAL ANDA 19 sections
LEXAPRO HUMAN PRESCRIPTION DRUG LABEL 1 16590-139 TABLET, FILM COATED 10 mg ORAL NDA 20 sections
LEXAPRO HUMAN PRESCRIPTION DRUG LABEL 1 16590-833 TABLET, FILM COATED 5 mg ORAL NDA 20 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 16729-168 TABLET, FILM COATED 5 mg ORAL ANDA 18 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 16729-169 TABLET, FILM COATED 10 mg ORAL ANDA 18 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 16729-170 TABLET, FILM COATED 20 mg ORAL ANDA 18 sections
Escitalopram Oxalate HUMAN PRESCRIPTION DRUG LABEL 1 17856-0551 SOLUTION 5 mg ORAL ANDA 20 sections