escitalopram 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1053 128196-01-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • escitalopram
  • (+)-(S)-Citalopram
  • (+)-Citalopram
  • (S)-Citalopram
  • S-(+)-Citalopram
  • seroplex
  • escitalopram oxalate
  • Molecular weight: 324.40
  • Formula: C20H21FN2O
  • CLOGP: 3.13
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 36.26
  • ALOGS: -4.74
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 8 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.88 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
fu (Fraction unbound in plasma) 0.36 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

DateAgencyCompanyOrphan
Aug. 14, 2002 FDA FOREST LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Suicide attempt 559.73 9.60 760 173267 60158 63254837
Suicidal ideation 540.84 9.60 757 173270 61664 63253331
Intentional overdose 486.73 9.60 790 173237 73362 63241633
Pemphigus 480.98 9.60 4 174023 183722 63131273
Electrocardiogram QT prolonged 464.54 9.60 687 173340 58843 63256152
Serotonin syndrome 405.40 9.60 445 173582 28237 63286758
Hand deformity 382.46 9.60 12 174015 159445 63155550
Contraindicated product administered 375.26 9.60 71 173956 217577 63097418
Synovitis 368.45 9.60 41 173986 186877 63128118
Sopor 354.09 9.60 367 173660 21797 63293198
Systemic lupus erythematosus 352.08 9.60 72 173955 208846 63106149
Glossodynia 340.81 9.60 44 173983 178832 63136163
Drug interaction 325.02 9.60 1366 172661 227765 63087230
Somnolence 316.65 9.60 1143 172884 177542 63137453
Arthropathy 308.01 9.60 129 173898 234663 63080332
Anxiety 307.02 9.60 1295 172732 216246 63098749
Completed suicide 302.87 9.60 983 173044 144690 63170305
Depression 286.05 9.60 1181 172846 195311 63119684
Overdose 283.40 9.60 824 173203 114254 63200741
Treatment failure 283.37 9.60 96 173931 198947 63116048
Joint swelling 281.39 9.60 290 173737 327376 62987619
Swelling 255.88 9.60 227 173800 275151 63039844
Wound 246.21 9.60 71 173956 163192 63151803
Pericarditis 242.01 9.60 36 173991 131543 63183452
Drug intolerance 236.92 9.60 299 173728 308362 63006633
Alopecia 233.99 9.60 352 173675 337184 62977811
Infusion related reaction 228.53 9.60 202 173825 245319 63069676
Duodenal ulcer perforation 223.07 9.60 3 174024 87206 63227789
Helicobacter infection 215.43 9.60 9 174018 92776 63222219
Tremor 212.49 9.60 820 173207 131419 63183576
Rheumatoid factor positive 207.34 9.60 5 174022 84401 63230594
Hyponatraemia 194.79 9.60 712 173315 111188 63203807
Intentional self-injury 193.90 9.60 292 173735 25395 63289600
Product substitution issue 173.96 9.60 217 173810 15779 63299216
Inappropriate antidiuretic hormone secretion 166.94 9.60 209 173818 15253 63299742
Drug ineffective 166.02 9.60 1952 172075 1042813 62272182
Rheumatoid arthritis 156.86 9.60 285 173742 253534 63061461
Abdominal discomfort 156.50 9.60 411 173616 320474 62994521
Folliculitis 156.26 9.60 9 174018 70308 63244687
Hepatic enzyme increased 153.03 9.60 198 173829 202130 63112865
Therapeutic product effect decreased 150.32 9.60 185 173842 193002 63121993
Agitation 147.09 9.60 428 173599 59329 63255666
Muscle injury 146.33 9.60 8 174019 65337 63249658
Lower respiratory tract infection 144.68 9.60 92 173935 132215 63182780
Coma 140.57 9.60 442 173585 63922 63251073
Akathisia 132.84 9.60 144 173883 9002 63305993
Discomfort 122.25 9.60 168 173859 167206 63147789
Peripheral swelling 121.85 9.60 351 173676 265591 63049404
Impaired healing 121.03 9.60 65 173962 102477 63212518
Maternal exposure during pregnancy 117.30 9.60 269 173758 219793 63095202
Stomatitis 114.16 9.60 127 173900 138598 63176397
Arthralgia 113.25 9.60 1008 173019 568702 62746293
Withdrawal syndrome 112.46 9.60 199 173828 19798 63295197
Hypersensitivity 112.17 9.60 418 173609 292267 63022728
Seizure 112.16 9.60 684 173343 131950 63183045
Blister 111.10 9.60 115 173912 129699 63185296
Fall 107.92 9.60 1590 172437 390744 62924251
Product use issue 106.99 9.60 283 173744 220237 63094758
Rash 106.41 9.60 1004 173023 559867 62755128
Drug hypersensitivity 105.67 9.60 465 173562 310222 63004773
Tardive dyskinesia 104.95 9.60 123 173904 8379 63306616
Irritability 104.39 9.60 253 173774 31441 63283554
Mania 104.06 9.60 148 173879 12219 63302776
Infection 98.82 9.60 311 173716 228862 63086133
C-reactive protein abnormal 93.62 9.60 9 174018 46087 63268908
Torsade de pointes 91.27 9.60 145 173882 13206 63301789
Panic attack 88.75 9.60 192 173835 22139 63292856
Reversible airways obstruction 88.65 9.60 58 173969 1784 63313211
Mobility decreased 88.06 9.60 122 173905 121037 63193958
Dyskinesia 87.34 9.60 238 173789 31764 63283231
Vital capacity decreased 87.07 9.60 56 173971 1672 63313323
Crying 86.33 9.60 195 173832 23148 63291847
Muscle rigidity 85.74 9.60 130 173897 11370 63303625
Loss of consciousness 83.26 9.60 582 173445 117539 63197456
Drug abuse 82.86 9.60 406 173621 72112 63242883
Irritable bowel syndrome 82.53 9.60 63 173964 82349 63232646
Depressed mood 81.38 9.60 269 173758 39922 63275073
Reversible cerebral vasoconstriction syndrome 80.20 9.60 63 173964 2595 63312400
Bronchial secretion retention 79.97 9.60 64 173963 2709 63312286
Mental disorder 76.03 9.60 198 173829 25721 63289274
Pain 75.77 9.60 1504 172523 739124 62575871
Sputum culture positive 75.59 9.60 56 173971 2111 63312884
Poisoning deliberate 75.53 9.60 121 173906 11097 63303898
Restlessness 74.43 9.60 213 173814 29240 63285755
Mydriasis 73.80 9.60 124 173903 11832 63303163
Hip arthroplasty 73.11 9.60 20 174007 47626 63267369
Long QT syndrome 72.60 9.60 65 173962 3214 63311781
Galactorrhoea 72.17 9.60 72 173955 4083 63310912
Suicidal behaviour 72.07 9.60 59 173968 2580 63312415
Extrapyramidal disorder 71.88 9.60 130 173897 13154 63301841
Tonsillar ulcer 71.33 9.60 28 173999 275 63314720
Ill-defined disorder 69.28 9.60 73 173954 81682 63233313
Neuroleptic malignant syndrome 69.11 9.60 121 173906 11935 63303060
C-reactive protein increased 68.18 9.60 96 173931 94611 63220384
Psychotic disorder 67.96 9.60 189 173838 25523 63289472
Dermatitis atopic 67.01 9.60 106 173921 9618 63305377
Sympathomimetic effect 66.88 9.60 20 174007 76 63314919
Hyperhidrosis 66.66 9.60 515 173512 107321 63207674
Apathy 66.40 9.60 100 173927 8694 63306301
Disturbance in attention 65.54 9.60 242 173785 37947 63277048
Paranoia 65.38 9.60 116 173911 11563 63303432
Insomnia 64.08 9.60 885 173142 214367 63100628
Knee arthroplasty 63.02 9.60 35 173992 54171 63260824
Toxicity to various agents 62.80 9.60 989 173038 246261 63068734
Foetal exposure during pregnancy 62.12 9.60 211 173816 31751 63283244
Off label use 61.78 9.60 1394 172633 673068 62641927
Inflammation 61.64 9.60 81 173946 82192 63232803
Hallucination, auditory 61.29 9.60 119 173908 12705 63302290
Emotional distress 60.75 9.60 212 173815 32337 63282658
Cholecystitis chronic 59.41 9.60 104 173923 10257 63304738
Stiff person syndrome 58.74 9.60 25 174002 307 63314688
Hallucination, visual 56.17 9.60 147 173880 19151 63295844
Psychomotor hyperactivity 55.98 9.60 103 173924 10560 63304435
Drug withdrawal syndrome neonatal 55.73 9.60 46 173981 2035 63312960
Nightmare 55.65 9.60 146 173881 19048 63295947
Pulmonary embolism 55.64 9.60 526 173501 116158 63198837
Feeling abnormal 55.19 9.60 636 173391 147756 63167239
Abnormal behaviour 55.16 9.60 156 173871 21270 63293725
Febrile neutropenia 55.15 9.60 155 173872 118294 63196701
Fibromyalgia 54.49 9.60 85 173942 80335 63234660
Multiple sclerosis relapse 54.36 9.60 270 173757 48208 63266787
Musculoskeletal stiffness 53.62 9.60 292 173735 184326 63130669
Dizziness 52.26 9.60 1545 172482 428380 62886615
Aggression 51.86 9.60 162 173865 23336 63291659
Pregnancy 51.57 9.60 219 173808 36617 63278378
Deep vein thrombosis 51.11 9.60 399 173628 83401 63231594
Hypertonia 50.56 9.60 63 173964 4574 63310421
Miosis 50.45 9.60 80 173947 7273 63307722
Electrocardiogram QRS complex prolonged 49.87 9.60 71 173956 5867 63309128
Depressed level of consciousness 49.83 9.60 316 173711 61762 63253233
Drug withdrawal syndrome 48.92 9.60 175 173852 27019 63287976
Delusion 48.53 9.60 104 173923 11913 63303082
Hallucination 48.39 9.60 286 173741 54531 63260464
Lip ulceration 48.11 9.60 42 173985 2008 63312987
Nasopharyngitis 47.67 9.60 456 173571 253801 63061194
Hyperreflexia 46.98 9.60 69 173958 5865 63309130
Lower respiratory tract infection viral 46.78 9.60 30 173997 891 63314104
Confusional state 46.54 9.60 908 173119 235472 63079523
Sepsis 46.23 9.60 239 173788 152884 63162111
Death 46.14 9.60 735 173292 373646 62941349
Liver injury 45.93 9.60 59 173968 60461 63254534
Sinus bradycardia 45.62 9.60 114 173913 14437 63300558
Small for dates baby 44.20 9.60 53 173974 3698 63311297
Syncope 44.04 9.60 504 173523 116881 63198114
Oculogyric crisis 43.93 9.60 37 173990 1684 63313311
Psoriatic arthropathy 43.92 9.60 118 173909 91402 63223593
Bruxism 43.51 9.60 51 173976 3474 63311521
Pyrexia 43.08 9.60 972 173055 469506 62845489
Anger 42.70 9.60 101 173926 12355 63302640
Sinusitis 42.69 9.60 406 173621 226247 63088748
Red blood cell sedimentation rate abnormal 42.55 9.60 3 174024 19779 63295216
Congenital absence of vertebra 42.29 9.60 12 174015 36 63314959
Multiple sclerosis 42.28 9.60 155 173872 24217 63290778
Tachycardia 41.97 9.60 502 173525 117654 63197341
Dystonia 40.97 9.60 106 173921 13713 63301282
Abnormal dreams 40.17 9.60 89 173938 10427 63304568
Cerebral haematoma 40.10 9.60 50 173977 3633 63311362
Bradyphrenia 39.94 9.60 70 173957 6910 63308085
Vertigo 39.80 9.60 291 173736 59596 63255399
Osteoporosis 39.42 9.60 60 173967 57278 63257717
Clonus 38.30 9.60 55 173972 4581 63310414
Alcoholism 38.21 9.60 35 173992 1783 63313212
Psychomotor retardation 38.13 9.60 50 173977 3820 63311175
Pyramidal tract syndrome 38.04 9.60 19 174008 344 63314651
Disease progression 37.96 9.60 190 173837 122568 63192427
Hostility 37.33 9.60 35 173992 1837 63313158
Mental status changes 37.16 9.60 210 173817 39389 63275606
Swollen tongue 37.03 9.60 191 173836 34609 63280386
Bipolar disorder 36.99 9.60 73 173954 7887 63307108
Activation syndrome 36.92 9.60 16 174011 206 63314789
Anhedonia 36.56 9.60 88 173939 10886 63304109
Cardiac arrest 35.00 9.60 398 173629 92147 63222848
Product administered to patient of inappropriate age 35.00 9.60 44 173983 3224 63311771
Libido increased 34.50 9.60 29 173998 1316 63313679
Blood cholesterol increased 34.21 9.60 137 173890 93895 63221100
Head injury 33.90 9.60 157 173870 27239 63287756
Bursitis 33.77 9.60 31 173996 37010 63277985
Self-injurious ideation 33.71 9.60 39 173988 2620 63312375
Muscle twitching 33.21 9.60 124 173903 19544 63295451
Bundle branch block left 33.12 9.60 65 173962 6994 63308001
Disorientation 33.01 9.60 203 173824 39249 63275746
Amnesia 32.97 9.60 263 173764 55322 63259673
Generalised tonic-clonic seizure 32.80 9.60 162 173865 28854 63286141
Arthritis 32.73 9.60 185 173842 115736 63199259
Eosinophil count increased 32.58 9.60 84 173943 10844 63304151
Pneumocystis jirovecii pneumonia 32.57 9.60 4 174023 16910 63298085
Upper-airway cough syndrome 32.24 9.60 86 173941 11332 63303663
Chronic spontaneous urticaria 31.88 9.60 26 174001 1131 63313864
Homicidal ideation 31.62 9.60 31 173996 1721 63313274
Subdural hygroma 31.58 9.60 15 174012 242 63314753
Adjustment disorder with mixed anxiety and depressed mood 31.49 9.60 12 174015 108 63314887
Depressive symptom 31.47 9.60 47 173980 4055 63310940
Hypersomnia 31.47 9.60 115 173912 17940 63297055
Slow speech 31.29 9.60 29 173998 1500 63313495
Nausea 31.07 9.60 2731 171296 851740 62463255
Osteoarthritis 30.96 9.60 145 173882 95198 63219797
Foot deformity 30.93 9.60 19 174008 27834 63287161
Angle closure glaucoma 30.60 9.60 34 173993 2185 63312810
Respiratory arrest 30.55 9.60 173 173854 32472 63282523
Acute kidney injury 30.16 9.60 524 173503 262891 63052104
Optic nerve injury 29.79 9.60 19 174008 559 63314436
Gestational diabetes 29.78 9.60 69 173958 8327 63306668
Adverse drug reaction 29.72 9.60 115 173912 79599 63235396
Tinnitus 29.61 9.60 183 173844 35445 63279550
Restless legs syndrome 28.97 9.60 114 173913 18417 63296578
Wheezing 28.96 9.60 149 173878 95446 63219549
Derealisation 28.85 9.60 25 174002 1183 63313812
Torticollis 28.85 9.60 31 173996 1918 63313077
Treatment noncompliance 28.72 9.60 188 173839 37137 63277858
Skin ulcer 28.67 9.60 46 173981 42999 63271996
Rheumatoid nodule 28.67 9.60 6 174021 17149 63297846
Congenital pulmonary valve atresia 28.67 9.60 10 174017 68 63314927
Bradycardia 28.63 9.60 317 173710 72910 63242085
Sinus tachycardia 28.51 9.60 137 173890 24131 63290864
Rhabdomyolysis 28.31 9.60 212 173815 43739 63271256
Cytomegalovirus infection 28.26 9.60 11 174016 20941 63294054
Sexual dysfunction 27.96 9.60 46 173981 4313 63310682
Tongue biting 27.63 9.60 27 174000 1493 63313502
Memory impairment 27.55 9.60 420 173607 103838 63211157
Screaming 27.39 9.60 39 173988 3223 63311772
Tenosynovitis 27.21 9.60 3 174024 13792 63301203
Intentional product use issue 27.19 9.60 222 173805 127670 63187325
Somnambulism 27.18 9.60 52 173975 5491 63309504
Accidental overdose 26.96 9.60 131 173896 23178 63291817
Nervousness 26.93 9.60 161 173866 30818 63284177
Affective disorder 26.93 9.60 55 173972 6091 63308904
Mucosal inflammation 26.92 9.60 55 173972 46873 63268122
Parkinsonism 26.86 9.60 76 173951 10363 63304632
Thermohypoaesthesia 26.84 9.60 11 174016 122 63314873
Adverse event 26.80 9.60 95 173932 67464 63247531
Euphoric mood 26.66 9.60 48 173979 4839 63310156
Neutropenia 26.32 9.60 330 173697 174675 63140320
Morose 26.24 9.60 8 174019 33 63314962
Platelet aggregation inhibition 26.15 9.60 11 174016 131 63314864
Bone erosion 26.14 9.60 8 174019 17709 63297286
Sight disability 26.07 9.60 11 174016 132 63314863
Conversion disorder 26.01 9.60 28 173999 1736 63313259
Red blood cell sedimentation rate increased 25.70 9.60 51 173976 43931 63271064
Initial insomnia 25.69 9.60 54 173973 6103 63308892
Psychiatric symptom 25.61 9.60 49 173978 5174 63309821
Cardio-respiratory arrest 25.50 9.60 264 173763 59695 63255300
Sepsis neonatal 25.41 9.60 16 174011 460 63314535
Panic reaction 25.38 9.60 43 173984 4131 63310864
Major depression 25.33 9.60 63 173964 7955 63307040
Pulmonary fibrosis 25.17 9.60 44 173983 39765 63275230
Gastrointestinal disorder 25.15 9.60 234 173793 131005 63183990
Myoclonus 25.11 9.60 98 173929 15770 63299225
Yawning 25.09 9.60 22 174005 1058 63313937
Gun shot wound 25.08 9.60 11 174016 146 63314849
Cyanosis neonatal 25.03 9.60 15 174012 394 63314601
Multiple allergies 24.98 9.60 89 173938 13713 63301282
Constricted affect 24.79 9.60 6 174021 7 63314988
Lip dry 24.68 9.60 6 174021 15464 63299531
Drug screen positive 24.23 9.60 39 173988 3590 63311405
Musculoskeletal pain 24.07 9.60 151 173876 92126 63222869
Therapeutic product effect incomplete 23.95 9.60 223 173804 124833 63190162
Macular degeneration 23.93 9.60 19 174008 24357 63290638
Bone marrow failure 23.87 9.60 27 174000 29263 63285732
Negative thoughts 23.81 9.60 20 174007 907 63314088
Multiple organ dysfunction syndrome 23.73 9.60 78 173949 56674 63258321
Dysarthria 23.66 9.60 199 173828 42512 63272483
Obsessive-compulsive disorder 23.60 9.60 41 173986 4019 63310976
Ventricular dyskinesia 23.55 9.60 10 174017 122 63314873
Oral candidiasis 23.37 9.60 17 174010 22781 63292214
Moaning 23.28 9.60 19 174008 827 63314168
Neutropenic sepsis 23.23 9.60 8 174019 16430 63298565
Maternal drugs affecting foetus 23.07 9.60 47 173980 5195 63309800
Facet joint syndrome 23.06 9.60 3 174024 12135 63302860
Large intestine anastomosis 22.93 9.60 7 174020 29 63314966
Mental impairment 22.89 9.60 88 173939 14063 63300932
Renal impairment 22.83 9.60 145 173882 88210 63226785
Hypertension 22.76 9.60 587 173440 278716 63036279
Stoma obstruction 22.72 9.60 10 174017 134 63314861
Libido decreased 22.51 9.60 32 173995 2640 63312355
Post-traumatic neck syndrome 22.33 9.60 28 173999 2046 63312949
Haemoglobin urine 22.33 9.60 10 174017 140 63314855
General physical health deterioration 22.29 9.60 403 173624 200999 63113996
Head banging 22.25 9.60 14 174013 402 63314593
Bundle branch block right 22.22 9.60 45 173982 4953 63310042
Pancytopenia 22.12 9.60 165 173862 96768 63218227
Polydipsia 22.04 9.60 37 173990 3527 63311468
Hyperthermia 21.96 9.60 65 173962 9091 63305904
Immobilisation prolonged 21.79 9.60 9 174018 102 63314893
Postictal state 21.77 9.60 20 174007 1023 63313972
Tearfulness 21.75 9.60 40 173987 4099 63310896
Fear 21.50 9.60 93 173934 15673 63299322
Extradural haematoma 21.40 9.60 25 174002 1697 63313298
Complication of device insertion 21.38 9.60 57 173970 7507 63307488
Hepatitis infectious mononucleosis 21.33 9.60 9 174018 108 63314887
Dysphoria 21.24 9.60 44 173983 4922 63310073
Lethargy 21.23 9.60 241 173786 55766 63259229
Panniculitis 21.18 9.60 3 174024 11382 63303613
Antiphospholipid antibodies 21.13 9.60 10 174017 160 63314835
Peripheral venous disease 21.08 9.60 8 174019 15469 63299526
Hepatic function abnormal 20.91 9.60 44 173983 37098 63277897
Bradypnoea 20.83 9.60 36 173991 3514 63311481
Type 2 diabetes mellitus 20.81 9.60 97 173930 63771 63251224
Dyspnoea 20.71 9.60 1547 172480 659766 62655229
Emotional disorder 20.66 9.60 82 173945 13297 63301698
Concussion 20.64 9.60 64 173963 9180 63305815
Heavy menstrual bleeding 20.64 9.60 100 173927 17673 63297322
Platelet count decreased 20.58 9.60 211 173816 115911 63199084
Genital hypoaesthesia 20.45 9.60 6 174021 21 63314974
Sebaceous gland infection 20.43 9.60 10 174017 173 63314822
Hyperventilation 20.32 9.60 49 173978 6067 63308928
Hypomania 20.27 9.60 50 173977 6280 63308715
Drowning 20.08 9.60 14 174013 479 63314516
Unresponsive to stimuli 20.05 9.60 160 173867 33656 63281339
Disseminated intravascular coagulation 19.79 9.60 14 174013 19037 63295958
Antidepressant discontinuation syndrome 19.77 9.60 7 174020 50 63314945
Serum serotonin 19.61 9.60 4 174023 0 63314995
Poisoning 19.60 9.60 82 173945 13618 63301377
Malignant neoplasm progression 19.60 9.60 138 173889 81983 63233012
Gastroschisis 19.58 9.60 13 174014 410 63314585
Thinking abnormal 19.58 9.60 69 173958 10574 63304421
Behaviour disorder 19.51 9.60 33 173994 3166 63311829
Tracheal atresia 19.44 9.60 6 174021 26 63314969
Orbital swelling 19.31 9.60 7 174020 54 63314941
Sputum culture 19.28 9.60 11 174016 263 63314732
Oedema 19.16 9.60 173 173854 97449 63217546
Retinal ischaemia 19.09 9.60 12 174015 344 63314651
Hepatitis chronic active 19.09 9.60 7 174020 56 63314939
Vision blurred 19.04 9.60 356 173671 91568 63223427
Hypervigilance 19.03 9.60 12 174015 346 63314649
Atrioventricular block 19.02 9.60 55 173972 7592 63307403
Feeling jittery 19 9.60 80 173947 13323 63301672
Hypertensive cardiomyopathy 18.95 9.60 10 174017 204 63314791
Epilepsy 18.84 9.60 133 173894 26932 63288063
Right ventricular dilatation 18.83 9.60 21 174006 1355 63313640
Rectal ulcer 18.78 9.60 20 174007 1225 63313770
Intermenstrual bleeding 18.75 9.60 56 173971 7870 63307125
Blood lactic acid 18.74 9.60 8 174019 99 63314896
Band sensation 18.73 9.60 17 174010 856 63314139
Blood prolactin increased 18.59 9.60 34 173993 3469 63311526
Alcohol abuse 18.52 9.60 26 174001 2120 63312875
Cerebral thrombosis 18.48 9.60 23 174004 1668 63313327
Breast swelling 18.46 9.60 21 174006 1385 63313610
Catarrh 18.44 9.60 22 174005 1527 63313468
Retroplacental haematoma 18.42 9.60 9 174018 155 63314840
Stress 18.29 9.60 272 173755 66895 63248100
Feeling of despair 18.23 9.60 27 174000 2312 63312683
Psoriasis 18.09 9.60 337 173690 86620 63228375
Pneumonia 18.09 9.60 1046 172981 455721 62859274
Suspected suicide 18.07 9.60 49 173978 6519 63308476
Learning disorder 18.05 9.60 15 174012 670 63314325
Psychomotor skills impaired 17.98 9.60 27 174000 2341 63312654
Feeling hot 17.89 9.60 214 173813 50140 63264855
Brain injury 17.85 9.60 51 173976 6992 63308003
Biliary dyskinesia 17.78 9.60 29 173998 2700 63312295
Colitis microscopic 17.57 9.60 61 173966 9278 63305717
Device placement issue 17.57 9.60 20 174007 1320 63313675
Middle insomnia 17.56 9.60 75 173952 12568 63302427
Pruritus 17.49 9.60 811 173216 360642 62954353
Loss of libido 17.46 9.60 20 174007 1329 63313666
Amaurosis 17.44 9.60 14 174013 595 63314400
Septic shock 17.39 9.60 109 173918 66520 63248475
Hyperdynamic left ventricle 17.35 9.60 9 174018 177 63314818
Soft tissue injury 17.31 9.60 22 174005 1630 63313365
Persecutory delusion 17.30 9.60 29 173998 2761 63312234
Acute myocardial infarction 17.30 9.60 39 173988 32085 63282910
Barotrauma 17.26 9.60 9 174018 179 63314816
Uterine perforation 17.24 9.60 50 173977 6913 63308082
Burns second degree 17.13 9.60 24 174003 1954 63313041
Caesarean section 17.10 9.60 92 173935 16940 63298055
Respiratory disorder neonatal 17.04 9.60 19 174008 1226 63313769
Cytotoxic oedema 17.04 9.60 9 174018 184 63314811
Tonsillitis 17.01 9.60 44 173983 5691 63309304
Oromandibular dystonia 17.01 9.60 13 174014 514 63314481
Trunk injury 16.93 9.60 5 174022 18 63314977
Neonatal hypoxia 16.93 9.60 14 174013 621 63314374
Creatinine renal clearance decreased 16.92 9.60 12 174015 16296 63298699
Respiratory disorder 16.84 9.60 53 173974 39029 63275966
Cardiogenic shock 16.76 9.60 95 173932 17837 63297158
Orgasm abnormal 16.74 9.60 7 174020 82 63314913
Drug resistance 16.74 9.60 23 174004 22910 63292085
Partner stress 16.68 9.60 12 174015 432 63314563
Foreign body in reproductive tract 16.68 9.60 15 174012 746 63314249
Cardiac failure 16.62 9.60 160 173867 88982 63226013
Decreased interest 16.54 9.60 31 173996 3223 63311772
Substance abuse 16.50 9.60 39 173988 4768 63310227
Balance disorder 16.48 9.60 324 173703 84098 63230897
Impulsive behaviour 16.45 9.60 21 174006 1562 63313433
Gallbladder disorder 16.43 9.60 98 173929 18744 63296251
Bipolar I disorder 16.38 9.60 23 174004 1876 63313119
Dissociation 16.35 9.60 29 173998 2890 63312105
Alcohol use 16.21 9.60 24 174003 2055 63312940
Self-medication 16.19 9.60 28 173999 2735 63312260
Ventricular fibrillation 16.18 9.60 70 173957 11797 63303198
Cardiac hypertrophy 16.14 9.60 17 174010 1028 63313967
Ocular hypertension 16.07 9.60 17 174010 1033 63313962
Hyperphagia 16.02 9.60 22 174005 1757 63313238
Victim of sexual abuse 16.02 9.60 14 174013 670 63314325
Respiratory tract infection 15.94 9.60 179 173848 41304 63273691
Left ventricle outflow tract obstruction 15.93 9.60 10 174017 286 63314709
Blood creatinine increased 15.82 9.60 159 173868 87685 63227310
Microcephaly 15.80 9.60 16 174011 924 63314071
Product substitution error 15.79 9.60 5 174022 24 63314971
Exercise lack of 15.76 9.60 11 174016 377 63314618
Cogwheel rigidity 15.73 9.60 23 174004 1947 63313048
Femur fracture 15.71 9.60 60 173967 41696 63273299
Essential tremor 15.57 9.60 17 174010 1071 63313924
Headache 15.56 9.60 1972 172055 631269 62683726
Hepatotoxicity 15.42 9.60 51 173976 36990 63278005
Magnetic resonance imaging head abnormal 15.35 9.60 23 174004 1990 63313005
Interstitial lung disease 15.28 9.60 103 173924 61805 63253190
Anti-actin antibody positive 15.24 9.60 4 174023 8 63314987
Congenital diaphragmatic eventration 15.24 9.60 4 174023 8 63314987
COVID-19 15.22 9.60 412 173615 112691 63202304
Post concussion syndrome 15.16 9.60 12 174015 500 63314495
Drug dependence 15.15 9.60 117 173910 24366 63290629
Bronchial hyperreactivity 15.13 9.60 21 174006 1694 63313301
Hypokalaemia 15.09 9.60 382 173645 103422 63211573
Catatonia 15.02 9.60 36 173991 4441 63310554
Hypercholesterolaemia 14.97 9.60 22 174005 21312 63293683
Disinhibition 14.78 9.60 15 174012 868 63314127
Periorbital inflammation 14.77 9.60 6 174021 65 63314930
Sternal fracture 14.75 9.60 24 174003 2230 63312765
Therapeutic response unexpected 14.74 9.60 95 173932 18664 63296331
Drug metabolite level high 14.71 9.60 3 174024 0 63314995
Steroid dependence 14.68 9.60 21 174006 1743 63313252
Bundle branch block 14.45 9.60 15 174012 892 63314103
Convulsive threshold lowered 14.35 9.60 10 174017 342 63314653
Prothrombin level increased 14.32 9.60 9 174018 258 63314737
Haematotoxicity 14.26 9.60 4 174023 9372 63305623
Carcinoid syndrome 14.20 9.60 7 174020 123 63314872
Osteonecrosis of jaw 14.19 9.60 49 173978 35074 63279921
Logorrhoea 14.14 9.60 25 174002 2485 63312510
Hypocoagulable state 14.13 9.60 17 174010 1190 63313805
Subdural haematoma 14.12 9.60 77 173950 14251 63300744
Mood swings 14.09 9.60 92 173935 18156 63296839
Attention-seeking behaviour 14.07 9.60 6 174021 74 63314921
Transplant rejection 13.99 9.60 6 174021 10774 63304221
Joint hyperextension 13.97 9.60 10 174017 357 63314638
Joint range of motion decreased 13.95 9.60 44 173983 32384 63282611
Sleep disorder 13.94 9.60 307 173720 81259 63233736
Convulsions local 13.86 9.60 4 174023 13 63314982
Focal dyscognitive seizures 13.83 9.60 27 174000 2894 63312101
Autoimmune disorder 13.82 9.60 16 174011 17161 63297834
Bone swelling 13.81 9.60 20 174007 1678 63313317
Flight of ideas 13.80 9.60 11 174016 463 63314532
Haemorrhagic stroke 13.78 9.60 41 173986 5751 63309244
Incision site haemorrhage 13.76 9.60 12 174015 573 63314422
Gastrointestinal procedural complication 13.74 9.60 8 174019 199 63314796
Obsessive thoughts 13.65 9.60 12 174015 579 63314416
Hemianopia 13.64 9.60 16 174011 1091 63313904
Gambling disorder 13.64 9.60 17 174010 1235 63313760
Cerebellar syndrome 13.57 9.60 30 173997 3509 63311486
Bradykinesia 13.57 9.60 38 173989 5150 63309845
Skin necrosis 13.54 9.60 11 174016 13939 63301056
Compulsions 13.46 9.60 8 174019 207 63314788
Dysgeusia 13.44 9.60 191 173836 46519 63268476
Sleep-related eating disorder 13.42 9.60 14 174013 837 63314158
Neonatal tachycardia 13.42 9.60 4 174023 15 63314980
Withdrawal catatonia 13.40 9.60 6 174021 84 63314911
Pain in extremity 13.30 9.60 758 173269 330728 62984267
Stoma site discharge 13.26 9.60 19 174008 1579 63313416
Snoring 13.26 9.60 33 173994 4169 63310826
Hypopnoea 13.20 9.60 31 173996 3775 63311220
Flat affect 13.16 9.60 18 174009 1432 63313563
Spinal cord oedema 13.12 9.60 7 174020 146 63314849
Sciatica 13.12 9.60 49 173978 34275 63280720
Device expulsion 13.11 9.60 150 173877 34772 63280223
Apnoea 13.07 9.60 50 173977 7972 63307023
Extensor plantar response 13.01 9.60 17 174010 1294 63313701
Orthostatic hypotension 12.99 9.60 154 173873 36006 63278989
Staring 12.97 9.60 19 174008 1611 63313384
Enterococcus test positive 12.89 9.60 16 174011 1157 63313838
Grip strength decreased 12.88 9.60 26 174001 22261 63292734
Pupil fixed 12.85 9.60 20 174007 1789 63313206
Pulmonary contusion 12.84 9.60 4 174023 18 63314977
Narrow anterior chamber angle 12.84 9.60 5 174022 48 63314947
Neuromyelitis optica spectrum disorder 12.83 9.60 15 174012 1019 63313976
Haematoma 12.82 9.60 149 173878 34671 63280324
Colour blindness 12.81 9.60 9 174018 312 63314683
Paraesthesia 12.75 9.60 539 173488 156427 63158568
Neonatal anuria 12.75 9.60 5 174022 49 63314946
Metamyelocyte count increased 12.74 9.60 8 174019 229 63314766
Disease recurrence 12.68 9.60 125 173902 27905 63287090
Wrong product procured 12.64 9.60 3 174024 3 63314992
Cerebral arteriovenous malformation haemorrhagic 12.64 9.60 3 174024 3 63314992
Impaired gastric emptying 12.63 9.60 59 173968 10273 63304722
Transposition of the great vessels 12.61 9.60 8 174019 233 63314762
Fatigue 12.53 9.60 2193 171834 885835 62429160
Anticholinergic syndrome 12.49 9.60 23 174004 2359 63312636
Superior sagittal sinus thrombosis 12.45 9.60 13 174014 778 63314217
Anterograde amnesia 12.42 9.60 11 174016 536 63314459
Illusion 12.41 9.60 15 174012 1055 63313940
Inappropriate schedule of product administration 12.40 9.60 373 173654 103592 63211403
Amenorrhoea 12.40 9.60 57 173970 9857 63305138
Neutrophil count decreased 12.40 9.60 97 173930 56309 63258686
Hypotension 12.38 9.60 887 173140 271717 63043278
Nuchal rigidity 12.38 9.60 12 174015 657 63314338
Gastrointestinal toxicity 12.35 9.60 3 174024 7738 63307257
Diplopia 12.33 9.60 109 173918 23619 63291376
Immunodeficiency 12.25 9.60 23 174004 20231 63294764
Social avoidant behaviour 12.23 9.60 26 174001 2962 63312033
Poor quality sleep 12.19 9.60 95 173932 19840 63295155
Product dose omission issue 12.17 9.60 771 173256 233542 63081453
Ejection fraction decreased 12.12 9.60 27 174000 22305 63292690
Holoprosencephaly 12.03 9.60 4 174023 23 63314972
Nystagmus 12.03 9.60 41 173986 6179 63308816
Blunted affect 11.98 9.60 8 174019 255 63314740
Bile acid malabsorption 11.95 9.60 7 174020 176 63314819
Mucosal ulceration 11.95 9.60 14 174013 953 63314042
Labelled drug-drug interaction medication error 11.88 9.60 70 173957 13329 63301666
Blood pressure diastolic decreased 11.88 9.60 28 173999 22678 63292317
Tonic clonic movements 11.82 9.60 17 174010 1418 63313577
Coma scale abnormal 11.81 9.60 36 173991 5117 63309878
Urinary hesitation 11.80 9.60 22 174005 2278 63312717
Impaired driving ability 11.76 9.60 33 173994 4478 63310517
Fibrous histiocytoma 11.75 9.60 11 174016 576 63314419
Laryngectomy 11.75 9.60 4 174023 25 63314970
Eosinophil count abnormal 11.74 9.60 11 174016 577 63314418
Ovarian vein thrombosis 11.71 9.60 5 174022 62 63314933
Joint dislocation 11.68 9.60 21 174006 18779 63296216
Investigation abnormal 11.68 9.60 20 174007 1938 63313057
Incoherent 11.67 9.60 33 173994 4497 63310498
Choroidal effusion 11.67 9.60 10 174017 466 63314529
Multimorbidity 11.64 9.60 11 174016 583 63314412
Myocardial infarction 11.64 9.60 198 173829 99695 63215300
Psychotic disorder due to a general medical condition 11.62 9.60 8 174019 268 63314727
Sleep talking 11.62 9.60 14 174013 982 63314013
Parotid gland enlargement 11.58 9.60 13 174014 845 63314150
Lupus-like syndrome 11.51 9.60 15 174012 15280 63299715
Liver disorder 11.49 9.60 93 173934 53594 63261401
Wound healing normal 11.43 9.60 3 174024 6 63314989
Atrophy of globe 11.43 9.60 3 174024 6 63314989
Retching 11.41 9.60 74 173953 14571 63300424
Creatinine urine decreased 11.38 9.60 7 174020 193 63314802
Endometrial disorder 11.37 9.60 12 174015 727 63314268
Jaundice cholestatic 11.37 9.60 3 174024 7321 63307674
Sleep disorder due to a general medical condition 11.35 9.60 10 174017 12178 63302817
Urinary incontinence 11.35 9.60 136 173891 31878 63283117
Idiopathic orbital inflammation 11.31 9.60 7 174020 195 63314800
Dissociative disorder 11.31 9.60 9 174018 378 63314617
Neonatal respiratory depression 11.29 9.60 5 174022 68 63314927
Sedation 11.29 9.60 159 173868 38650 63276345
Adjustment disorder with depressed mood 11.28 9.60 7 174020 10197 63304798
Dextrocardia 11.25 9.60 4 174023 29 63314966
Hypernatraemia 11.24 9.60 46 173981 7563 63307432
Lung diffusion disorder 11.16 9.60 5 174022 70 63314925
Disturbance in sexual arousal 11.13 9.60 6 174021 128 63314867
Breast cancer stage II 11.12 9.60 5 174022 8731 63306264
Compulsive shopping 11.11 9.60 12 174015 747 63314248
Road traffic accident 11.03 9.60 151 173876 36481 63278514
Biliary colic 10.99 9.60 28 173999 3589 63311406
Cor pulmonale acute 10.95 9.60 9 174018 396 63314599
Metastases to bone 10.93 9.60 26 174001 20993 63294002
Tachyphrenia 10.91 9.60 16 174011 1358 63313637
Pulse absent 10.90 9.60 36 173991 5338 63309657
Violence-related symptom 10.89 9.60 9 174018 399 63314596
Antipsychotic drug level increased 10.86 9.60 27 174000 3408 63311587
Acute myeloid leukaemia 10.79 9.60 19 174008 17128 63297867
Aphasia 10.75 9.60 138 173889 32862 63282133
Pulseless electrical activity 10.75 9.60 45 173982 7476 63307519
Palpitations 10.74 9.60 394 173633 112376 63202619
Sleep deficit 10.72 9.60 11 174016 645 63314350
Abdominal wall haematoma 10.72 9.60 25 174002 3030 63311965
Obstructive airways disorder 10.71 9.60 95 173932 20604 63294391
Anaemia 10.70 9.60 677 173350 292753 63022242
Lung disorder 10.67 9.60 114 173913 62147 63252848
Alcohol poisoning 10.66 9.60 19 174008 1900 63313095
CSF pressure increased 10.61 9.60 6 174021 141 63314854
Cyclic vomiting syndrome 10.61 9.60 6 174021 141 63314854
Meningocele 10.57 9.60 3 174024 9 63314986
Migraine 10.56 9.60 364 173663 102982 63212013
Hot flush 10.55 9.60 198 173829 50961 63264034
Speech disorder 10.47 9.60 163 173864 40466 63274529
Sluggishness 10.43 9.60 35 173992 5234 63309761
Congenital tracheomalacia 10.40 9.60 4 174023 37 63314958
Electrocardiogram P wave abnormal 10.40 9.60 7 174020 226 63314769
Housebound 10.37 9.60 7 174020 227 63314768
Food craving 10.37 9.60 17 174010 1589 63313406
Oesophageal atresia 10.35 9.60 10 174017 545 63314450
Cytarabine syndrome 10.35 9.60 5 174022 84 63314911
Intensive care unit acquired weakness 10.34 9.60 12 174015 809 63314186
Optic atrophy 10.32 9.60 15 174012 1263 63313732
Inflammatory marker increased 10.25 9.60 3 174024 6836 63308159
Red blood cells urine 10.20 9.60 10 174017 555 63314440
Cluster headache 10.17 9.60 11 174016 686 63314309
Belligerence 10.10 9.60 6 174021 155 63314840
Enuresis 10.08 9.60 22 174005 2551 63312444
Tubulointerstitial nephritis and uveitis syndrome 10.08 9.60 7 174020 238 63314757
Arthropod bite 10.08 9.60 46 173981 7932 63307063
Maternal exposure during breast feeding 10.07 9.60 30 173997 4211 63310784
Cellulitis 10.03 9.60 161 173866 81797 63233198
Erythema 10.02 9.60 387 173640 175364 63139631
Menometrorrhagia 10.01 9.60 13 174014 984 63314011
Mood altered 10.00 9.60 72 173955 14671 63300324
Movement disorder 9.99 9.60 97 173930 21564 63293431
Extrasystoles 9.97 9.60 34 173993 5126 63309869
Mitochondrial myopathy 9.94 9.60 5 174022 92 63314903
Functional residual capacity increased 9.94 9.60 5 174022 92 63314903
Pancreatic carcinoma recurrent 9.94 9.60 5 174022 92 63314903
Hypotonia 9.90 9.60 51 173976 9234 63305761
Sialoadenitis 9.87 9.60 17 174010 1655 63313340
Ecchymosis 9.86 9.60 58 173969 11036 63303959
Apallic syndrome 9.86 9.60 11 174016 710 63314285
Polyarthritis 9.84 9.60 8 174019 10138 63304857
Nephropathy toxic 9.80 9.60 7 174020 9472 63305523
Tobacco abuse 9.80 9.60 11 174016 715 63314280
Head titubation 9.80 9.60 12 174015 856 63314139
Coordination abnormal 9.77 9.60 68 173959 13705 63301290
Emotional poverty 9.75 9.60 8 174019 351 63314644
Electrocardiogram U wave present 9.75 9.60 5 174022 96 63314899
Weight abnormal 9.75 9.60 15 174012 1329 63313666
Normal newborn 9.73 9.60 47 173980 8294 63306701
Exposure via breast milk 9.72 9.60 19 174008 2038 63312957
Female sexual dysfunction 9.71 9.60 4 174023 45 63314950
Hemiplegic migraine 9.70 9.60 5 174022 97 63314898
Mechanical urticaria 9.69 9.60 9 174018 467 63314528
Anorgasmia 9.65 9.60 10 174017 593 63314402
Weight increased 9.62 9.60 835 173192 259957 63055038

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 446.53 10.29 363 77075 19570 34859923
Completed suicide 329.11 10.29 693 76745 97475 34782018
Suicidal ideation 319.65 10.29 420 77018 39968 34839525
Suicide attempt 317.70 10.29 412 77026 38704 34840789
Intentional overdose 269.37 10.29 403 77035 43271 34836222
Agitation 189.53 10.29 403 77035 56996 34822497
Anxiety 166.08 10.29 541 76897 98887 34780606
Aggression 155.38 10.29 296 77142 38668 34840825
Foetal exposure during pregnancy 152.62 10.29 290 77148 37811 34841682
Somnolence 150.43 10.29 564 76874 110552 34768941
Depression 145.09 10.29 509 76929 96589 34782904
Tremor 120.81 10.29 430 77008 82157 34797336
Intentional self-injury 114.75 10.29 147 77291 13624 34865869
Sopor 106.60 10.29 133 77305 12003 34867490
Withdrawal syndrome 105.43 10.29 134 77304 12321 34867172
Overdose 101.36 10.29 435 77003 90624 34788869
Mania 97.92 10.29 113 77325 9398 34870095
Electrocardiogram QT prolonged 92.28 10.29 248 77190 40704 34838789
Intrusive thoughts 87.31 10.29 31 77407 284 34879209
Disturbance in attention 85.36 10.29 182 77256 25763 34853730
Sexual dysfunction 84.34 10.29 86 77352 6217 34873276
Paranoia 83.99 10.29 118 77320 11950 34867543
Drug interaction 83.51 10.29 815 76623 225131 34654362
Poisoning deliberate 82.10 10.29 94 77344 7750 34871743
Mycotic allergy 80.37 10.29 35 77403 573 34878920
Insomnia 80.16 10.29 447 76991 103460 34776033
Febrile neutropenia 76.91 10.29 115 77323 136734 34742759
Mite allergy 75.55 10.29 35 77403 667 34878826
Major depression 75.47 10.29 70 77368 4502 34874991
Spirometry abnormal 74.51 10.29 35 77403 689 34878804
Confusional state 74.25 10.29 560 76878 143600 34735893
Muscle rigidity 70.47 10.29 101 77337 10417 34869076
Sedation 69.84 10.29 148 77290 20858 34858635
Drug withdrawal syndrome 68.58 10.29 142 77296 19692 34859801
Maternal drugs affecting foetus 67.97 10.29 62 77376 3903 34875590
Dust allergy 67.07 10.29 35 77403 871 34878622
Restlessness 66.37 10.29 163 77275 25319 34854174
Panic attack 65.30 10.29 92 77346 9340 34870153
Loss of libido 64.66 10.29 50 77388 2502 34876991
Dyskinesia 64.46 10.29 149 77289 22264 34857229
Conjunctivitis allergic 63.97 10.29 37 77401 1133 34878360
Coma 62.64 10.29 233 77205 45445 34834048
Irritability 62.26 10.29 156 77282 24534 34854959
Fall 60.90 10.29 702 76736 202183 34677310
Anger 59.82 10.29 100 77338 11784 34867709
Interstitial lung disease 58.63 10.29 36 77402 65246 34814247
Tachyphrenia 58.62 10.29 36 77402 1233 34878260
Erectile dysfunction 58.04 10.29 136 77302 20501 34858992
Libido decreased 57.32 10.29 61 77377 4635 34874858
Pyrexia 57.20 10.29 468 76970 332545 34546948
Activation syndrome 57.18 10.29 17 77421 82 34879411
Neutropenia 56.78 10.29 169 77269 156609 34722884
Hyperreflexia 56.66 10.29 51 77387 3155 34876338
Homicidal ideation 54.10 10.29 46 77392 2636 34876857
Septic shock 53.68 10.29 48 77390 71786 34807707
Apathy 53.09 10.29 71 77367 6861 34872632
Respiratory disorder neonatal 52.72 10.29 37 77401 1593 34877900
Thrombocytopenia 52.65 10.29 174 77264 156073 34723420
Mood swings 51.66 10.29 75 77363 7826 34871667
Product substitution issue 50.88 10.29 85 77353 10010 34869483
Hypomania 50.77 10.29 42 77396 2317 34877176
Multiple organ dysfunction syndrome 49.46 10.29 58 77380 76508 34802985
Renal impairment 48.76 10.29 84 77354 94429 34785064
Sepsis 48.54 10.29 197 77241 166364 34713129
Pneumonia 48.49 10.29 542 76896 362085 34517408
Drug withdrawal syndrome neonatal 47.73 10.29 49 77389 3570 34875923
Malignant neoplasm progression 47.51 10.29 76 77362 87970 34791523
Akathisia 45.94 10.29 72 77366 8037 34871456
Hyperhidrosis 45.88 10.29 306 77132 75386 34804107
Gun shot wound 44.60 10.29 29 77409 1099 34878394
Hallucination, visual 44.42 10.29 112 77326 17679 34861814
Chest injury 44.34 10.29 33 77405 1558 34877935
Anorgasmia 43.95 10.29 26 77412 831 34878662
Tardive dyskinesia 43.88 10.29 59 77379 5731 34873762
Renal failure 43.55 10.29 146 77292 130411 34749082
Hallucination 41.98 10.29 225 77213 51273 34828220
Depressed mood 41.51 10.29 115 77323 19202 34860291
Abulia 41.08 10.29 22 77416 578 34878915
Craniosynostosis 41.06 10.29 19 77419 361 34879132
Small for dates baby 40.99 10.29 47 77391 3880 34875613
Catatonia 40.85 10.29 53 77385 4972 34874521
Neuroleptic malignant syndrome 40.77 10.29 109 77329 17825 34861668
Alcoholism 40.66 10.29 41 77397 2924 34876569
Mydriasis 40.64 10.29 64 77374 7173 34872320
Parkinsonism 40.32 10.29 68 77370 8070 34871423
Bipolar disorder 40.15 10.29 45 77393 3624 34875869
Infusion related reaction 38.98 10.29 36 77402 53021 34826472
Hallucination, auditory 38.50 10.29 83 77355 11834 34867659
Seizure 37.51 10.29 376 77062 104481 34775012
Abnormal behaviour 36.44 10.29 130 77308 24839 34854654
Pregnancy 36.30 10.29 16 77422 270 34879223
Foetal malformation 36.06 10.29 13 77425 125 34879368
Reduced facial expression 35.83 10.29 25 77413 1066 34878427
Social avoidant behaviour 35.46 10.29 39 77399 3075 34876418
Off label use 34.85 10.29 688 76750 418836 34460657
Self esteem decreased 34.77 10.29 19 77419 520 34878973
Anaemia 34.67 10.29 340 77098 232995 34646498
Postictal psychosis 34.45 10.29 14 77424 191 34879302
Bone marrow failure 34.31 10.29 11 77427 29242 34850251
Sleep disorder 34.14 10.29 150 77288 31538 34847955
Homicide 34.13 10.29 23 77415 926 34878567
Memory impairment 33.78 10.29 187 77251 43131 34836362
Impulsive behaviour 33.57 10.29 32 77406 2130 34877363
Amnesia 33.52 10.29 132 77306 26431 34853062
Cerebral haematoma 33.41 10.29 46 77392 4569 34874924
Resting tremor 33.18 10.29 20 77418 662 34878831
Mental disorder 33.13 10.29 91 77347 15118 34864375
Anencephaly 32.26 10.29 12 77426 127 34879366
Electrocardiogram QT interval 32.03 10.29 9 77429 34 34879459
Myoclonus 31.97 10.29 88 77350 14637 34864856
Extrapyramidal disorder 31.03 10.29 80 77358 12800 34866693
Delusion 30.98 10.29 79 77359 12556 34866937
Skin dystrophy 30.97 10.29 7 77431 7 34879486
Painful respiration 30.84 10.29 24 77414 1212 34878281
Acute kidney injury 30.76 10.29 483 76955 304505 34574988
Device dislocation 30.67 10.29 52 77386 6197 34873296
Anhedonia 30.67 10.29 58 77380 7527 34871966
Clonus 30.56 10.29 34 77404 2716 34876777
Atrial septal defect 30.48 10.29 57 77381 7335 34872158
Feeling abnormal 30.45 10.29 242 77196 62993 34816500
Cardiac failure 30.44 10.29 102 77336 91146 34788347
Loss of consciousness 29.34 10.29 296 77142 82371 34797122
Persecutory delusion 28.84 10.29 32 77406 2548 34876945
Inappropriate antidiuretic hormone secretion 28.47 10.29 77 77361 12676 34866817
Normochromic normocytic anaemia 28.47 10.29 41 77397 4246 34875247
Drug screen positive 28.10 10.29 39 77399 3904 34875589
Blood creatinine increased 27.84 10.29 112 77326 94864 34784629
Congenital ureteropelvic junction obstruction 27.71 10.29 9 77429 61 34879432
Psychomotor hyperactivity 27.69 10.29 64 77374 9558 34869935
Consciousness fluctuating 27.37 10.29 22 77416 1165 34878328
Emotional disorder 27.31 10.29 47 77391 5669 34873824
Alcohol use 27.23 10.29 35 77403 3253 34876240
Urinary retention 27.19 10.29 155 77283 36133 34843360
Walking aid user 27.11 10.29 27 77411 1897 34877596
Disorientation 27.03 10.29 145 77293 33043 34846450
Myelosuppression 26.97 10.29 5 77433 19260 34860233
Infantile apnoea 26.93 10.29 20 77418 941 34878552
Cogwheel rigidity 26.88 10.29 23 77415 1329 34878164
Hyperthermia 26.84 10.29 67 77371 10510 34868983
Psychotic disorder 26.53 10.29 116 77322 24336 34855157
Reversible cerebral vasoconstriction syndrome 26.45 10.29 15 77423 442 34879051
Ascites 26.25 10.29 39 77399 46532 34832961
Psychomotor retardation 25.85 10.29 36 77402 3614 34875879
Mental impairment 25.79 10.29 65 77373 10257 34869236
Dyspnoea 25.76 10.29 637 76801 376145 34503348
Electrocardiogram QRS complex prolonged 25.73 10.29 42 77396 4852 34874641
Bruxism 25.66 10.29 25 77413 1710 34877783
Abnormal clotting factor 25.59 10.29 9 77429 80 34879413
Choanal stenosis 25.57 10.29 5 77433 0 34879493
Delirium 25.53 10.29 176 77262 43815 34835678
Bradyphrenia 24.99 10.29 41 77397 4757 34874736
Platelet count decreased 24.93 10.29 159 77279 119558 34759935
Postural orthostatic tachycardia syndrome 24.83 10.29 9 77429 88 34879405
Apraxia 24.78 10.29 22 77416 1336 34878157
Physical deconditioning 24.77 10.29 22 77416 1337 34878156
Steroid dependence 24.60 10.29 23 77415 1494 34877999
Cognitive disorder 24.49 10.29 127 77311 28566 34850927
Prescribed overdose 24.49 10.29 65 77373 10582 34868911
Inhibitory drug interaction 24.36 10.29 24 77414 1664 34877829
Poor quality sleep 23.85 10.29 55 77383 8201 34871292
Total lung capacity abnormal 23.81 10.29 10 77428 149 34879344
Sleep disorder due to a general medical condition 23.74 10.29 42 77396 5179 34874314
Death 23.29 10.29 688 76750 397361 34482132
Respiratory failure 23.23 10.29 143 77295 108429 34771064
Torsade de pointes 23.04 10.29 50 77388 7159 34872334
Orthostatic hypotension 23.02 10.29 116 77322 25803 34853690
Hypersomnia 22.94 10.29 70 77368 12337 34867156
Gambling disorder 22.85 10.29 23 77415 1637 34877856
Derealisation 22.75 10.29 15 77423 582 34878911
Cytomegalovirus infection 22.65 10.29 15 77423 26120 34853373
Disseminated intravascular coagulation 22.58 10.29 10 77428 21806 34857687
Feeling guilty 22.55 10.29 12 77426 311 34879182
Agitation neonatal 22.52 10.29 19 77419 1077 34878416
Legal problem 22.51 10.29 10 77428 172 34879321
Priapism 22.48 10.29 40 77398 4954 34874539
Pruritus 22.28 10.29 204 77234 141777 34737716
Libido increased 22.27 10.29 17 77421 834 34878659
Neonatal pneumonia 21.94 10.29 9 77429 126 34879367
Bradypnoea 21.70 10.29 29 77409 2800 34876693
Orgasm abnormal 21.69 10.29 9 77429 130 34879363
Oedema peripheral 21.57 10.29 166 77272 119646 34759847
Negative thoughts 21.57 10.29 15 77423 636 34878857
Infection 21.45 10.29 116 77322 90799 34788694
Gastrointestinal hypermotility 21.26 10.29 9 77429 137 34879356
Dissociation 21.06 10.29 22 77416 1636 34877857
Nightmare 21.06 10.29 75 77363 14316 34865177
Toxic encephalopathy 21.05 10.29 40 77398 5209 34874284
Impaired work ability 20.95 10.29 47 77391 6883 34872610
Cardiac failure congestive 20.91 10.29 104 77334 83166 34796327
Stomatitis 20.82 10.29 39 77399 42475 34837018
Toxic epidermal necrolysis 20.77 10.29 11 77427 21635 34857858
Depressed level of consciousness 20.64 10.29 164 77274 42677 34836816
Burnout syndrome 20.63 10.29 9 77429 148 34879345
Congenital hearing disorder 20.54 10.29 8 77430 97 34879396
Electrocardiogram QT interval abnormal 20.54 10.29 8 77430 97 34879396
Post-traumatic stress disorder 20.46 10.29 23 77415 1858 34877635
Gynaecomastia 20.30 10.29 59 77379 10121 34869372
Crying 20.29 10.29 42 77396 5820 34873673
Abnormal dreams 20.28 10.29 49 77389 7529 34871964
Bradycardia neonatal 20.22 10.29 17 77421 959 34878534
Bronchopulmonary aspergillosis 20.10 10.29 4 77434 14655 34864838
Judgement impaired 20.04 10.29 14 77424 598 34878895
Depressive symptom 19.96 10.29 28 77410 2831 34876662
Neonatal respiratory distress 19.88 10.29 14 77424 606 34878887
Neuropathy peripheral 19.77 10.29 106 77332 83157 34796336
Ejaculation disorder 19.73 10.29 17 77421 992 34878501
Lactic acidosis 19.71 10.29 29 77409 34743 34844750
Medication error 19.68 10.29 110 77328 25455 34854038
Condition aggravated 19.63 10.29 561 76877 191635 34687858
Septum pellucidum agenesis 19.54 10.29 7 77431 66 34879427
Muscle necrosis 19.54 10.29 16 77422 870 34878623
Parkinsonian gait 19.52 10.29 13 77425 513 34878980
Tension 19.36 10.29 24 77414 2151 34877342
Urticaria 19.27 10.29 72 77366 62305 34817188
Drug eruption 19.25 10.29 10 77428 19888 34859605
Autoscopy 19.23 10.29 10 77428 247 34879246
Helplessness 19.17 10.29 7 77431 70 34879423
Leukopenia 19.13 10.29 73 77365 62783 34816710
Retrograde amnesia 18.94 10.29 8 77430 121 34879372
Hypoglycaemia neonatal 18.59 10.29 22 77416 1879 34877614
Bradykinesia 18.59 10.29 32 77406 3861 34875632
Brain stem haematoma 18.54 10.29 8 77430 128 34879365
Somatic symptom disorder 18.52 10.29 14 77424 677 34878816
Dissociative disorder 18.40 10.29 12 77426 457 34879036
Neutropenic sepsis 18.38 10.29 4 77434 13763 34865730
Trisomy 21 18.23 10.29 13 77425 574 34878919
Reactive psychosis 18.23 10.29 4 77434 3 34879490
Feeling of despair 18.17 10.29 16 77422 961 34878532
Dementia with Lewy bodies 18.09 10.29 14 77424 701 34878792
Exposure during pregnancy 18.03 10.29 52 77386 8882 34870611
Rheumatoid arthritis 17.92 10.29 36 77402 38202 34841291
Dementia 17.90 10.29 69 77369 13679 34865814
Physical assault 17.88 10.29 17 77421 1128 34878365
Thinking abnormal 17.86 10.29 41 77397 6096 34873397
Hyperglycaemia 17.80 10.29 38 77400 39442 34840051
Neonatal seizure 17.61 10.29 12 77426 492 34879001
Rash 17.60 10.29 368 77070 222384 34657109
Electrocardiogram QT shortened 17.58 10.29 8 77430 146 34879347
Renal dysplasia 17.58 10.29 9 77429 215 34879278
Aspergillus infection 17.54 10.29 3 77435 12251 34867242
Pneumocystis jirovecii pneumonia 17.51 10.29 11 77427 19699 34859794
Cough 17.46 10.29 231 77207 149909 34729584
Drug resistance 17.43 10.29 19 77419 25908 34853585
Disinhibition 17.39 10.29 28 77410 3198 34876295
Tumour lysis syndrome 17.38 10.29 8 77430 17051 34862442
Joint swelling 17.31 10.29 71 77367 59819 34819674
Hypokinesia 17.26 10.29 51 77387 8829 34870664
Arthralgia 17.19 10.29 269 77169 169772 34709721
Trisomy 18 17.16 10.29 14 77424 757 34878736
Anal incontinence 17.13 10.29 47 77391 7802 34871691
Palmar-plantar erythrodysaesthesia syndrome 16.91 10.29 8 77430 16787 34862706
Dysgraphia 16.87 10.29 23 77415 2264 34877229
Mucosal inflammation 16.73 10.29 38 77400 38584 34840909
Inflammation 16.63 10.29 23 77415 28272 34851221
Back pain 16.60 10.29 181 77257 121608 34757885
Persistent depressive disorder 16.59 10.29 10 77428 331 34879162
Contraindicated product administered 16.46 10.29 14 77424 21467 34858026
Poisoning 16.44 10.29 62 77376 12164 34867329
Urinary incontinence 16.43 10.29 84 77354 18790 34860703
Pelvic kidney 16.39 10.29 7 77431 109 34879384
Disease progression 16.21 10.29 157 77281 107920 34771573
Intensive care 16.02 10.29 12 77426 572 34878921
Obsessive-compulsive disorder 16.00 10.29 37 77401 5527 34873966
Erythema 15.98 10.29 123 77315 88657 34790836
Depersonalisation/derealisation disorder 15.84 10.29 12 77426 582 34878911
Personality disorder 15.74 10.29 16 77422 1152 34878341
Congenital hydronephrosis 15.67 10.29 13 77425 720 34878773
Behaviour disorder 15.63 10.29 34 77404 4876 34874617
Epilepsy 15.57 10.29 91 77347 21404 34858089
Premature ejaculation 15.52 10.29 7 77431 125 34879368
Cardiac discomfort 15.45 10.29 12 77426 604 34878889
Hypersensitivity 15.45 10.29 76 77362 60959 34818534
Hypertonia 15.38 10.29 31 77407 4215 34875278
Venous angioma of brain 15.38 10.29 5 77433 34 34879459
Sleep-related eating disorder 15.32 10.29 9 77429 284 34879209
Hepatotoxicity 15.28 10.29 15 77423 21470 34858023
Family stress 15.22 10.29 7 77431 131 34879362
Talipes 15.19 10.29 20 77418 1903 34877590
Neutrophil count decreased 15.13 10.29 60 77378 51044 34828449
Myocardial infarction 14.93 10.29 184 77254 120901 34758592
Chemical submission 14.90 10.29 5 77433 38 34879455
Pancytopenia 14.80 10.29 137 77301 95020 34784473
Panic disorder 14.79 10.29 16 77422 1238 34878255
Neonatal hyponatraemia 14.76 10.29 6 77432 82 34879411
Liver disorder 14.67 10.29 32 77406 32965 34846528
Feelings of worthlessness 14.61 10.29 9 77429 310 34879183
Ejaculation failure 14.55 10.29 13 77425 796 34878697
Congenital pulmonary hypertension 14.44 10.29 6 77432 87 34879406
Sperm concentration decreased 14.41 10.29 7 77431 149 34879344
Alcohol abuse 14.39 10.29 32 77406 4658 34874835
Logorrhoea 14.38 10.29 22 77416 2404 34877089
Graft versus host disease 14.25 10.29 3 77435 10566 34868927
Rapid eye movement sleep behaviour disorder 14.24 10.29 7 77431 153 34879340
Nodule 14.06 10.29 40 77398 6779 34872714
Fear 13.98 10.29 53 77385 10423 34869070
Atrial fibrillation 13.97 10.29 189 77249 122204 34757289
False positive investigation result 13.96 10.29 10 77428 445 34879048
Head discomfort 13.68 10.29 29 77409 4087 34875406
Generalised tonic-clonic seizure 13.66 10.29 87 77351 21087 34858406
Hypospadias 13.59 10.29 25 77413 3176 34876317
Illness anxiety disorder 13.57 10.29 7 77431 170 34879323
Personality change 13.51 10.29 33 77405 5106 34874387
Rabbit syndrome 13.50 10.29 4 77434 19 34879474
Stress 13.45 10.29 114 77324 30233 34849260
Haemophagocytic lymphohistiocytosis 13.34 10.29 6 77432 12967 34866526
White blood cell count decreased 13.34 10.29 141 77297 95304 34784189
Peripheral swelling 13.32 10.29 107 77331 76434 34803059
Pleural effusion 13.29 10.29 116 77322 81430 34798063
Delusional disorder, erotomanic type 13.27 10.29 3 77435 3 34879490
Bladder cancer 13.24 10.29 10 77428 16268 34863225
Hypophosphataemia 13.19 10.29 4 77434 11022 34868471
Rapid eye movements sleep abnormal 13.17 10.29 7 77431 181 34879312
Ureteric haemorrhage 13.16 10.29 6 77432 110 34879383
Somnambulism 13.06 10.29 24 77414 3048 34876445
Hypocalcaemia 13.06 10.29 21 77417 24268 34855225
Nasopharyngitis 13.03 10.29 96 77342 69872 34809621
Swelling 13.02 10.29 49 77389 42317 34837176
Male orgasmic disorder 12.97 10.29 6 77432 114 34879379
Loss of employment 12.85 10.29 10 77428 505 34878988
Renal haemorrhage 12.84 10.29 16 77422 1441 34878052
Social fear 12.81 10.29 3 77435 4 34879489
C-reactive protein increased 12.77 10.29 69 77369 54029 34825464
Abdominal pain 12.71 10.29 271 77167 163347 34716146
Anaphylactic shock 12.70 10.29 10 77428 15931 34863562
Panic reaction 12.69 10.29 16 77422 1459 34878034
Gastrointestinal haemorrhage 12.65 10.29 130 77308 88347 34791146
Hepatic failure 12.63 10.29 37 77401 34494 34844999
Hallucination, olfactory 12.57 10.29 7 77431 199 34879294
Haemoglobin decreased 12.55 10.29 190 77248 120582 34758911
Human herpesvirus 6 infection 12.52 10.29 19 77419 2062 34877431
Suicidal behaviour 12.50 10.29 16 77422 1481 34878012
Pain in extremity 12.49 10.29 201 77237 126312 34753181
Chronic kidney disease 12.45 10.29 48 77390 41162 34838331
Yawning 12.40 10.29 10 77428 532 34878961
Synovitis 12.29 10.29 8 77430 14058 34865435
Weight increased 12.25 10.29 281 77157 92752 34786741
Attention deficit hyperactivity disorder 12.17 10.29 21 77417 2538 34876955
Fluid retention 12.02 10.29 26 77412 26861 34852632
Tinnitus 11.97 10.29 81 77357 20037 34859456
Suspected suicide 11.96 10.29 30 77408 4718 34874775
Frustration tolerance decreased 11.95 10.29 21 77417 2575 34876918
Feeling jittery 11.93 10.29 27 77411 3976 34875517
Grandiosity 11.92 10.29 8 77430 320 34879173
Haemorrhage 11.86 10.29 66 77372 51304 34828189
Selective eating disorder 11.80 10.29 17 77421 1761 34877732
Palpitations 11.78 10.29 138 77300 39848 34839645
Dizziness 11.71 10.29 594 76844 217927 34661566
Electrocardiogram abnormal 11.70 10.29 46 77392 9201 34870292
Parosmia 11.66 10.29 20 77418 2405 34877088
Multiple drug therapy 11.61 10.29 9 77429 452 34879041
Pulmonary oedema 11.56 10.29 60 77378 47469 34832024
Prescription form tampering 11.52 10.29 9 77429 457 34879036
Prothrombin time abnormal 11.48 10.29 11 77427 737 34878756
Stress at work 11.44 10.29 7 77431 238 34879255
Dystonia 11.42 10.29 51 77387 10794 34868699
Lung neoplasm malignant 11.41 10.29 13 77425 17382 34862111
Congenital megaureter 11.40 10.29 6 77432 152 34879341
Obsessive-compulsive personality disorder 11.40 10.29 6 77432 152 34879341
Obsessive thoughts 11.39 10.29 11 77427 744 34878749
Carbon dioxide increased 11.39 10.29 13 77425 1068 34878425
Treatment failure 11.33 10.29 59 77379 46638 34832855
Leukocyte adhesion deficiency type I 11.33 10.29 4 77434 36 34879457
Posterior reversible encephalopathy syndrome 11.22 10.29 4 77434 9950 34869543
Nephropathy toxic 11.21 10.29 7 77431 12581 34866912
Cytokine release syndrome 11.18 10.29 21 77417 22856 34856637
Affect lability 11.16 10.29 25 77413 3658 34875835
Renal tubular necrosis 11.09 10.29 11 77427 15669 34863824
Psychogenic seizure 11.09 10.29 8 77430 360 34879133
Screaming 11.06 10.29 15 77423 1469 34878024
Theft 11.01 10.29 7 77431 255 34879238
Skin discolouration 11.00 10.29 14 77424 17831 34861662
Hyperammonaemic encephalopathy 10.96 10.29 19 77419 2305 34877188
Suture rupture 10.93 10.29 8 77430 368 34879125
Burns second degree 10.93 10.29 13 77425 1116 34878377
Mood altered 10.90 10.29 44 77394 8908 34870585
Neonatal tachypnoea 10.89 10.29 6 77432 167 34879326
Diarrhoea 10.88 10.29 731 76707 389181 34490312
Colitis microscopic 10.88 10.29 19 77419 2318 34877175
Congenital diaphragmatic hernia 10.79 10.29 7 77431 264 34879229
Sexually inappropriate behaviour 10.78 10.29 9 77429 503 34878990
Sprue-like enteropathy 10.76 10.29 9 77429 504 34878989
Colitis 10.75 10.29 45 77393 37705 34841788
Imprisonment 10.64 10.29 9 77429 512 34878981
Acute myeloid leukaemia 10.59 10.29 15 77423 18255 34861238
Hyponatriuria 10.54 10.29 3 77435 12 34879481
Ejaculation delayed 10.54 10.29 7 77431 275 34879218
Feminisation acquired 10.54 10.29 4 77434 45 34879448
Paresis 10.48 10.29 18 77420 2168 34877325
Catarrh 10.47 10.29 12 77426 990 34878503
Herpes zoster 10.43 10.29 40 77398 34359 34845134
Myositis 10.36 10.29 7 77431 12063 34867430
Cerebrospinal fluid circulation disorder 10.35 10.29 3 77435 13 34879480
Cerebral infarction 10.35 10.29 29 77409 27426 34852067

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Suicide attempt 687.03 9.64 935 197055 81997 79464401
Serotonin syndrome 656.70 9.64 678 197312 44349 79502049
Suicidal ideation 655.69 9.64 876 197114 75464 79470934
Completed suicide 600.29 9.64 1646 196344 244121 79302277
Intentional overdose 581.11 9.64 986 197004 104974 79441424
Sopor 440.22 9.64 474 197516 32536 79513862
Electrocardiogram QT prolonged 439.61 9.64 798 197192 89588 79456810
Somnolence 383.97 9.64 1385 196605 237596 79308802
Anxiety 342.08 9.64 1371 196619 247141 79299257
Overdose 299.47 9.64 1072 196918 183134 79363264
Drug interaction 295.21 9.64 1901 196089 413282 79133116
Depression 277.69 9.64 1170 196820 215620 79330778
Tremor 260.55 9.64 971 197019 169112 79377286
Agitation 252.08 9.64 677 197313 99038 79447360
Synovitis 249.61 9.64 38 197952 150696 79395702
Pemphigus 231.16 9.64 3 197987 99579 79446819
Intentional self-injury 226.22 9.64 337 197653 32082 79514316
Hand deformity 215.66 9.64 10 197980 103909 79442489
Contraindicated product administered 194.18 9.64 74 197916 157464 79388934
Coma 190.00 9.64 616 197374 100033 79446365
Joint swelling 184.57 9.64 269 197721 288377 79258021
Withdrawal syndrome 174.40 9.64 270 197720 26584 79519814
Inappropriate antidiuretic hormone secretion 171.50 9.64 265 197725 26048 79520350
Infusion related reaction 168.35 9.64 194 197796 230043 79316355
Arthropathy 166.77 9.64 118 197872 176993 79369405
Product substitution issue 162.48 9.64 225 197765 20031 79526367
Treatment failure 158.67 9.64 115 197875 170371 79376027
Mania 155.80 9.64 209 197781 18051 79528347
Drug intolerance 155.63 9.64 260 197730 263859 79282539
Aggression 151.58 9.64 368 197622 50590 79495808
Hyponatraemia 151.30 9.64 854 197136 176994 79369404
Duodenal ulcer perforation 149.44 9.64 3 197987 66208 79480190
Glossodynia 140.50 9.64 41 197949 103296 79443102
Fall 138.10 9.64 1831 196159 485798 79060600
Helicobacter infection 137.52 9.64 9 197981 69695 79476703
Poisoning deliberate 134.62 9.64 198 197792 18630 79527768
Irritability 133.08 9.64 307 197683 40837 79505561
Akathisia 132.31 9.64 164 197826 13095 79533303
Rheumatoid factor positive 130.16 9.64 4 197986 59835 79486563
Febrile neutropenia 129.15 9.64 235 197755 230764 79315634
Swelling 128.87 9.64 212 197778 216499 79329899
Systemic lupus erythematosus 127.42 9.64 71 197919 121078 79425320
Pericarditis 126.71 9.64 50 197940 104186 79442212
Muscle rigidity 119.57 9.64 193 197797 19689 79526709
Paranoia 118.73 9.64 190 197800 19242 79527156
Panic attack 117.87 9.64 214 197776 24002 79522396
Wound 115.26 9.64 73 197917 116106 79430292
Seizure 114.96 9.64 833 197157 188001 79358397
Mydriasis 109.85 9.64 174 197816 17469 79528929
Torsade de pointes 108.76 9.64 182 197808 19130 79527268
Mental disorder 101.71 9.64 234 197756 31068 79515330
Folliculitis 101.33 9.64 10 197980 55370 79491028
Tardive dyskinesia 101.09 9.64 128 197862 10443 79535955
Disturbance in attention 100.45 9.64 316 197674 50485 79495913
Reversible cerebral vasoconstriction syndrome 99.85 9.64 73 197917 2984 79543414
Stomatitis 99.50 9.64 131 197859 146626 79399772
Confusional state 97.44 9.64 1212 196778 316785 79229613
Hyperreflexia 95.62 9.64 111 197879 8274 79538124
Restlessness 95.44 9.64 293 197697 46199 79500199
Apathy 94.99 9.64 138 197852 12839 79533559
Dyskinesia 94.57 9.64 285 197705 44488 79501910
Muscle injury 93.68 9.64 7 197983 48554 79497844
Peripheral swelling 92.06 9.64 351 197639 269266 79277132
Depressed mood 90.79 9.64 296 197694 48184 79498214
Crying 90.55 9.64 186 197804 22857 79523541
Loss of consciousness 90.49 9.64 720 197270 167223 79379175
Lower respiratory tract infection 90.02 9.64 113 197877 129107 79417291
Infection 89.59 9.64 304 197686 241408 79304990
Electrocardiogram QRS complex prolonged 89.39 9.64 122 197868 10711 79535687
Alopecia 89.18 9.64 286 197704 231069 79315329
Drug withdrawal syndrome 88.96 9.64 237 197753 34481 79511917
Insomnia 88.23 9.64 964 197026 244206 79302192
Hyperhidrosis 84.66 9.64 655 197335 150837 79395561
Sepsis 84.28 9.64 363 197627 269065 79277333
C-reactive protein abnormal 82.82 9.64 11 197979 48356 79498042
Vital capacity decreased 82.12 9.64 53 197937 1763 79544635
Multiple organ dysfunction syndrome 81.85 9.64 107 197883 120139 79426259
Pyrexia 81.06 9.64 1192 196798 677517 78868881
Neuroleptic malignant syndrome 80.85 9.64 198 197792 27361 79519037
Arthralgia 80.73 9.64 970 197020 570833 78975565
Off label use 79.49 9.64 1684 196306 905531 78640867
Acute kidney injury 79.21 9.64 866 197124 518538 79027860
Sexual dysfunction 79.04 9.64 97 197893 7666 79538732
Anger 78.92 9.64 148 197842 17014 79529384
Drug hypersensitivity 78.27 9.64 429 197561 298487 79247911
Rheumatoid arthritis 78.06 9.64 261 197729 208209 79338189
Reversible airways obstruction 78.03 9.64 55 197935 2121 79544277
Rash 77.92 9.64 991 196999 577367 78969031
Neutropenia 77.50 9.64 409 197581 287301 79259097
Myelosuppression 77.19 9.64 6 197984 40290 79506108
Clonus 75.42 9.64 89 197901 6751 79539647
Hepatic enzyme increased 75.17 9.64 219 197771 182391 79364007
Inflammation 74.03 9.64 74 197916 93679 79452719
Hypersensitivity 73.90 9.64 367 197623 261872 79284526
Impaired healing 72.94 9.64 66 197924 87589 79458809
Spirometry abnormal 72.43 9.64 39 197951 920 79545478
Hallucination 71.04 9.64 409 197581 85336 79461062
Blister 70.87 9.64 117 197873 119359 79427039
Long QT syndrome 69.87 9.64 80 197910 5875 79540523
Hallucination, visual 69.74 9.64 209 197781 32520 79513878
Intrusive thoughts 68.60 9.64 31 197959 493 79545905
Activation syndrome 68.41 9.64 26 197964 259 79546139
Loss of libido 67.74 9.64 55 197935 2630 79543768
Abnormal behaviour 66.07 9.64 220 197770 36201 79510197
Homicidal ideation 65.26 9.64 60 197930 3397 79543001
Psychomotor hyperactivity 65.02 9.64 135 197855 16714 79529684
Libido decreased 65.01 9.64 73 197917 5248 79541150
C-reactive protein increased 64.54 9.64 140 197850 128887 79417511
Suicidal behaviour 64.52 9.64 58 197932 3189 79543209
Drug ineffective 63.71 9.64 2124 195866 1078789 78467609
Septic shock 63.30 9.64 131 197859 122670 79423728
Anhedonia 63.01 9.64 124 197866 14774 79531624
Psychotic disorder 62.98 9.64 236 197754 41166 79505232
Sympathomimetic effect 62.93 9.64 19 197971 85 79546313
Renal impairment 62.93 9.64 192 197798 157591 79388807
Interstitial lung disease 62.48 9.64 115 197875 112485 79433913
Extrapyramidal disorder 62.39 9.64 159 197831 22520 79523878
Discomfort 62.26 9.64 137 197853 125480 79420918
Therapeutic product effect decreased 62.12 9.64 204 197786 163659 79382739
Cerebral haematoma 61.87 9.64 87 197903 7855 79538543
Hallucination, auditory 61.05 9.64 149 197841 20544 79525854
Galactorrhoea 60.66 9.64 59 197931 3587 79542811
Multiple sclerosis relapse 60.11 9.64 252 197738 46281 79500117
Bruxism 59.33 9.64 61 197929 3965 79542433
Mobility decreased 58.31 9.64 136 197854 122039 79424359
Cytomegalovirus infection 57.80 9.64 17 197973 42627 79503771
Gun shot wound 57.52 9.64 36 197954 1134 79545264
Conjunctivitis allergic 56.01 9.64 41 197949 1679 79544719
Alcoholism 55.94 9.64 57 197933 3666 79542732
Derealisation 55.27 9.64 40 197950 1609 79544789
Depressed level of consciousness 55.14 9.64 420 197570 96232 79450166
Bronchial secretion retention 54.81 9.64 59 197931 4045 79542353
Hypertonia 54.53 9.64 78 197912 7154 79539244
Thrombocytopenia 54.43 9.64 410 197580 264849 79281549
Nightmare 54.02 9.64 164 197826 25697 79520701
Cardiac failure 53.83 9.64 200 197790 154642 79391756
Major depression 53.76 9.64 87 197903 8893 79537505
Mite allergy 53.42 9.64 35 197955 1195 79545203
Tachyphrenia 53.30 9.64 43 197947 2037 79544361
Feeling abnormal 53.15 9.64 617 197373 158582 79387816
Delusion 52.91 9.64 140 197850 20283 79526115
Bipolar disorder 52.16 9.64 79 197911 7628 79538770
Sputum culture positive 51.63 9.64 55 197935 3726 79542672
Cholecystitis chronic 51.36 9.64 90 197900 9816 79536582
Abdominal discomfort 51.22 9.64 388 197602 250339 79296059
Platelet count decreased 51.12 9.64 279 197711 194385 79352013
Parkinsonism 50.62 9.64 121 197869 16463 79529935
Libido increased 50.50 9.64 41 197949 1960 79544438
Bradyphrenia 50.48 9.64 93 197897 10547 79535851
Pneumonia 49.95 9.64 1253 196737 658993 78887405
Irritable bowel syndrome 49.28 9.64 49 197941 62192 79484206
Toxicity to various agents 48.78 9.64 1381 196609 420159 79126239
Emotional distress 48.20 9.64 212 197778 39757 79506641
Bone marrow failure 48.13 9.64 34 197956 51073 79495325
Hypersomnia 46.92 9.64 145 197845 22941 79523457
Hypomania 46.41 9.64 74 197916 7470 79538928
Product use issue 44.62 9.64 321 197669 209501 79336897
Mycotic allergy 44.54 9.64 34 197956 1485 79544913
Dust allergy 44.20 9.64 34 197956 1502 79544896
Psychomotor retardation 44.16 9.64 65 197925 6119 79540279
Fibromyalgia 44.03 9.64 57 197933 64283 79482115
Mucosal inflammation 43.90 9.64 75 197915 75505 79470893
Malignant neoplasm progression 43.85 9.64 181 197809 135809 79410589
Abnormal dreams 43.52 9.64 91 197899 11321 79535077
Multiple sclerosis 43.48 9.64 138 197852 22144 79524254
Pancytopenia 43.27 9.64 238 197752 165507 79380891
Knee arthroplasty 43.12 9.64 27 197963 43221 79503177
Device dislocation 42.85 9.64 152 197838 25818 79520580
Tonsillar ulcer 42.58 9.64 21 197969 410 79545988
Drug screen positive 42.25 9.64 63 197927 6000 79540398
Pneumocystis jirovecii pneumonia 42.20 9.64 14 197976 32494 79513904
Disease progression 42.19 9.64 276 197714 184086 79362312
Catatonia 42.13 9.64 77 197913 8679 79537719
Hyperthermia 42.10 9.64 119 197871 17918 79528480
Dermatitis atopic 41.68 9.64 83 197907 9973 79536425
Myoclonus 40.69 9.64 156 197834 27504 79518894
Self esteem decreased 39.87 9.64 27 197963 975 79545423
Generalised tonic-clonic seizure 39.38 9.64 214 197776 43696 79502702
Alcohol use 39.24 9.64 54 197936 4777 79541621
Disseminated intravascular coagulation 39.15 9.64 20 197970 35822 79510576
Hip arthroplasty 38.98 9.64 20 197970 35736 79510662
Pulmonary embolism 38.31 9.64 619 197371 171035 79375363
Screaming 38.20 9.64 48 197942 3885 79542513
Disorientation 38.19 9.64 277 197713 62499 79483899
Neutropenic sepsis 38.15 9.64 10 197980 27054 79519344
Blood creatinine increased 38.13 9.64 227 197763 154830 79391568
Musculoskeletal stiffness 38.05 9.64 266 197724 174742 79371656
Social avoidant behaviour 37.89 9.64 53 197937 4761 79541637
Amnesia 37.65 9.64 277 197713 62780 79483618
Death 37.62 9.64 1095 196895 565419 78980979
Abulia 37.09 9.64 26 197964 994 79545404
Osteoporosis 36.97 9.64 48 197942 54064 79492334
Drug abuse 36.80 9.64 588 197402 162103 79384295
Dizziness 36.57 9.64 1627 196363 524814 79021584
Memory impairment 36.37 9.64 431 197559 111303 79435095
Nasopharyngitis 36.36 9.64 429 197561 253452 79292946
Impulsive behaviour 35.79 9.64 40 197950 2860 79543538
Persecutory delusion 35.63 9.64 52 197938 4857 79541541
Adjustment disorder with mixed anxiety and depressed mood 35.47 9.64 13 197977 116 79546282
Anaemia 35.38 9.64 838 197152 444177 79102221
Red blood cell sedimentation rate abnormal 35.34 9.64 5 197985 20958 79525440
Sinus bradycardia 35.20 9.64 140 197850 25107 79521291
Hepatic function abnormal 35.18 9.64 81 197909 73026 79473372
Muscle twitching 35.07 9.64 138 197852 24626 79521772
Ill-defined disorder 35.03 9.64 69 197921 65806 79480592
Torticollis 34.88 9.64 36 197954 2351 79544047
Vertigo 34.39 9.64 291 197699 68791 79477607
Hostility 34.04 9.64 35 197955 2275 79544123
Bradypnoea 34.03 9.64 57 197933 5995 79540403
Negative thoughts 33.91 9.64 28 197962 1371 79545027
Aspergillus infection 33.67 9.64 4 197986 19157 79527241
Dyspnoea 33.57 9.64 1763 196227 855262 78691136
Sedation 33.32 9.64 232 197758 51663 79494735
Myocardial infarction 33.00 9.64 295 197695 183834 79362564
Maternal exposure during pregnancy 32.99 9.64 201 197789 136337 79410061
Optic nerve injury 32.65 9.64 20 197970 606 79545792
Mood swings 32.49 9.64 116 197874 19764 79526634
Upper-airway cough syndrome 32.18 9.64 82 197908 11611 79534787
Head injury 32.09 9.64 180 197810 37189 79509209
Dystonia 31.73 9.64 121 197869 21278 79525120
Orgasm abnormal 30.92 9.64 13 197977 172 79546226
Emotional disorder 30.77 9.64 92 197898 14295 79532103
Complication of device insertion 30.75 9.64 56 197934 6294 79540104
Chronic spontaneous urticaria 30.72 9.64 25 197965 1199 79545199
Erectile dysfunction 30.63 9.64 93 197897 14571 79531827
Cogwheel rigidity 30.50 9.64 38 197952 3050 79543348
Pain 30.40 9.64 1433 196557 702369 78844029
Sleep disorder 30.36 9.64 336 197654 85341 79461057
Anorgasmia 30.19 9.64 25 197965 1229 79545169
Restless legs syndrome 30.11 9.64 114 197876 19978 79526420
Resting tremor 29.89 9.64 27 197963 1494 79544904
Device expulsion 29.55 9.64 135 197855 25726 79520672
Alcohol abuse 29.47 9.64 50 197940 5313 79541085
Syncope 29.17 9.64 616 197374 178833 79367565
Pregnancy 29.08 9.64 138 197852 26713 79519685
Sinusitis 28.90 9.64 328 197662 195173 79351225
Oculogyric crisis 28.63 9.64 36 197954 2916 79543482
Mental impairment 28.52 9.64 108 197882 18928 79527470
Poor quality sleep 28.52 9.64 122 197868 22600 79523798
Bone erosion 28.41 9.64 5 197985 17842 79528556
Somnambulism 28.40 9.64 51 197939 5670 79540728
Miosis 28.30 9.64 95 197895 15694 79530704
Drug resistance 28.27 9.64 38 197952 42175 79504223
Bronchopulmonary aspergillosis 28.25 9.64 10 197980 22284 79524114
Red blood cell sedimentation rate increased 28.16 9.64 44 197946 45898 79500500
Headache 28.09 9.64 1933 196057 651839 78894559
Legal problem 28.06 9.64 12 197978 166 79546232
Sinus tachycardia 27.96 9.64 172 197818 36736 79509662
Tachycardia 27.86 9.64 607 197383 177161 79369237
Renal failure 27.85 9.64 342 197648 200626 79345772
Depressive symptom 27.82 9.64 54 197936 6369 79540029
Arthritis 27.81 9.64 169 197821 114711 79431687
Deep vein thrombosis 27.70 9.64 438 197552 120481 79425917
Psoriatic arthropathy 27.59 9.64 100 197890 77899 79468499
Rheumatoid nodule 27.51 9.64 5 197985 17433 79528965
Gestational diabetes 27.37 9.64 53 197937 6240 79540158
Epilepsy 27.02 9.64 184 197806 40676 79505722
Suspected suicide 26.89 9.64 72 197918 10504 79535894
Lip ulceration 26.88 9.64 31 197959 2294 79544104
Stiff person syndrome 26.88 9.64 14 197976 308 79546090
Nervousness 26.76 9.64 158 197832 33257 79513141
Feeling of despair 26.72 9.64 34 197956 2787 79543611
Feeling guilty 26.71 9.64 20 197970 848 79545550
Lower respiratory tract infection viral 26.66 9.64 23 197967 1197 79545201
Acute myocardial infarction 26.44 9.64 100 197890 76936 79469462
Morose 26.11 9.64 8 197982 38 79546360
Skin ulcer 26.05 9.64 60 197930 54090 79492308
Swollen tongue 25.98 9.64 188 197802 42382 79504016
Bundle branch block left 25.94 9.64 75 197915 11438 79534960
Platelet aggregation inhibition 25.93 9.64 11 197979 149 79546249
Respiratory arrest 25.83 9.64 237 197753 57313 79489085
Mental status changes 25.77 9.64 267 197723 66692 79479706
Reduced facial expression 25.68 9.64 33 197957 2732 79543666
Bradycardia 25.61 9.64 476 197514 135081 79411317
Dissociative disorder 25.45 9.64 19 197971 802 79545596
Ascites 25.34 9.64 99 197891 75463 79470935
Angle closure glaucoma 25.29 9.64 34 197956 2942 79543456
Fear 25.29 9.64 115 197875 21871 79524527
Thermohypoaesthesia 25.27 9.64 10 197980 112 79546286
Thinking abnormal 25.21 9.64 81 197909 13080 79533318
Pruritus 25.11 9.64 767 197223 393881 79152517
Orthostatic hypotension 25.06 9.64 231 197759 55933 79490465
Initial insomnia 24.93 9.64 54 197936 6884 79539514
Obsessive-compulsive disorder 24.66 9.64 49 197941 5878 79540520
Feeling jittery 24.57 9.64 79 197911 12762 79533636
Pulmonary fibrosis 24.51 9.64 45 197945 44067 79502331
Neutrophil count decreased 24.47 9.64 135 197855 93824 79452574
Yawning 24.42 9.64 23 197967 1343 79545055
Multiple allergies 24.40 9.64 69 197921 10391 79536007
Logorrhoea 24.39 9.64 41 197949 4324 79542074
Sepsis neonatal 24.28 9.64 8 197982 50 79546348
Neuropathy peripheral 24.18 9.64 229 197761 141076 79405322
Transplant rejection 24.15 9.64 9 197981 19428 79526970
Disinhibition 24.12 9.64 31 197959 2567 79543831
Foot deformity 24.04 9.64 15 197975 24059 79522339
Learning disorder 23.99 9.64 16 197974 563 79545835
Moaning 23.97 9.64 21 197969 1116 79545282
Hepatotoxicity 23.83 9.64 58 197932 51294 79495104
Tumour lysis syndrome 23.79 9.64 15 197975 23924 79522474
Sight disability 23.74 9.64 10 197980 133 79546265
Pyramidal tract syndrome 23.55 9.64 16 197974 581 79545817
Conversion disorder 23.54 9.64 26 197964 1835 79544563
Urinary retention 23.33 9.64 229 197761 56401 79489997
Dysphoria 23.24 9.64 42 197948 4692 79541706
Poisoning 23.22 9.64 124 197866 25148 79521250
Postictal state 23.22 9.64 26 197964 1863 79544535
Bundle branch block right 23.17 9.64 71 197919 11180 79535218
Muscle necrosis 23.15 9.64 23 197967 1435 79544963
Device placement issue 22.88 9.64 21 197969 1186 79545212
Blood prolactin increased 22.85 9.64 38 197952 3973 79542425
Post-traumatic neck syndrome 22.68 9.64 27 197963 2067 79544331
Affective disorder 22.54 9.64 58 197932 8261 79538137
Ejaculation failure 22.53 9.64 13 197977 352 79546046
Behaviour disorder 22.53 9.64 49 197941 6264 79540134
Haemoglobin urine 22.48 9.64 10 197980 153 79546245
Haemoglobin decreased 22.44 9.64 402 197588 221717 79324681
Hyperglycaemia 22.42 9.64 94 197896 70241 79476157
Panic reaction 22.41 9.64 41 197949 4624 79541774
Burns second degree 22.29 9.64 30 197960 2598 79543800
Erythema 22.28 9.64 405 197585 222885 79323513
Drug tolerance decreased 22.10 9.64 3 197987 12975 79533423
Antidepressant discontinuation syndrome 21.92 9.64 7 197983 39 79546359
Hypertension 21.86 9.64 640 197350 330352 79216046
Treatment noncompliance 21.84 9.64 212 197778 52056 79494342
Catarrh 21.83 9.64 27 197963 2151 79544247
Gambling disorder 21.74 9.64 26 197964 2000 79544398
Bradykinesia 21.72 9.64 56 197934 7987 79538411
Electrocardiogram QT interval 21.71 9.64 11 197979 228 79546170
Tinnitus 21.67 9.64 186 197804 44147 79502251
Judgement impaired 21.56 9.64 21 197969 1279 79545119
Middle insomnia 21.52 9.64 88 197902 15981 79530417
Uterine perforation 21.45 9.64 48 197942 6255 79540143
Self-injurious ideation 21.44 9.64 35 197955 3603 79542795
Sebaceous gland infection 21.42 9.64 10 197980 172 79546226
Heavy menstrual bleeding 21.42 9.64 80 197910 13931 79532467
Dysgraphia 21.38 9.64 37 197953 3995 79542403
Bursitis 21.34 9.64 35 197955 35809 79510589
Antiphospholipid antibodies 21.21 9.64 9 197981 122 79546276
Psychiatric symptom 21.12 9.64 51 197939 6984 79539414
Family stress 21.09 9.64 16 197974 692 79545706
Sleep-related eating disorder 20.97 9.64 16 197974 698 79545700
Tongue biting 20.78 9.64 26 197964 2095 79544303
Anaphylactic shock 20.64 9.64 36 197954 35960 79510438
Slow speech 20.58 9.64 28 197962 2450 79543948
Tearfulness 20.53 9.64 46 197944 5999 79540399
Victim of sexual abuse 20.37 9.64 14 197976 518 79545880
Lethargy 20.37 9.64 299 197691 80993 79465405
Withdrawal catatonia 20.29 9.64 10 197980 195 79546203
Eosinophil count increased 20.07 9.64 90 197900 17015 79529383
Migraine 20.07 9.64 317 197673 87176 79459222
Euphoric mood 20.05 9.64 53 197937 7673 79538725
Cardio-respiratory arrest 19.79 9.64 379 197611 108131 79438267
Orbital swelling 19.77 9.64 7 197983 56 79546342
Pulmonary toxicity 19.74 9.64 4 197986 12910 79533488
Atrial fibrillation 19.72 9.64 359 197631 197527 79348871
Hepatitis infectious mononucleosis 19.59 9.64 9 197981 149 79546249
Band sensation 19.58 9.64 16 197974 772 79545626
Delirium 19.55 9.64 307 197683 84320 79462078
Acute myeloid leukaemia 19.49 9.64 29 197961 30856 79515542
Lip dry 19.39 9.64 7 197983 15411 79530987
Male orgasmic disorder 19.34 9.64 7 197983 60 79546338
Enterocolitis 19.28 9.64 6 197984 14506 79531892
White blood cell count decreased 19.26 9.64 340 197650 187948 79358450
Hypokinesia 19.24 9.64 96 197894 18964 79527434
Chest injury 19.21 9.64 29 197961 2792 79543606
Oedema 19.12 9.64 197 197793 119383 79427015
Impaired work ability 19.07 9.64 98 197892 19583 79526815
Tension 19.04 9.64 37 197953 4367 79542031
Dissociation 18.89 9.64 35 197955 3986 79542412
Pain in extremity 18.88 9.64 727 197263 363811 79182587
Full blood count abnormal 18.84 9.64 168 197822 40306 79506092
Osteoarthritis 18.82 9.64 133 197857 87176 79459222
Hypervigilance 18.80 9.64 13 197977 486 79545912
Creatinine renal clearance decreased 18.75 9.64 12 197978 18990 79527408
Peripheral venous disease 18.73 9.64 8 197982 15901 79530497
Cardiac failure congestive 18.72 9.64 245 197745 142157 79404241
Painful respiration 18.72 9.64 32 197958 3421 79542977
Post transplant lymphoproliferative disorder 18.72 9.64 3 197987 11461 79534937
Immobilisation prolonged 18.69 9.64 8 197982 111 79546287
Nephropathy toxic 18.69 9.64 14 197976 20405 79525993
Biliary dyskinesia 18.53 9.64 27 197963 2518 79543880
Foetal exposure during pregnancy 18.49 9.64 43 197947 5747 79540651
General physical health deterioration 18.47 9.64 531 197459 274707 79271691
Musculoskeletal pain 18.32 9.64 164 197826 102190 79444208
Obsessive thoughts 18.24 9.64 18 197972 1114 79545284
Intentional product use issue 18.11 9.64 267 197723 151845 79394553
Illness anxiety disorder 18.01 9.64 10 197980 251 79546147
Retroplacental haematoma 18.01 9.64 8 197982 122 79546276
Lupus-like syndrome 17.93 9.64 6 197984 13851 79532547
Constricted affect 17.87 9.64 5 197985 16 79546382
Steroid dependence 17.86 9.64 27 197963 2603 79543795
Head banging 17.85 9.64 13 197977 528 79545870
Liver disorder 17.80 9.64 106 197884 72311 79474087
Concussion 17.77 9.64 58 197932 9445 79536953
Colitis microscopic 17.74 9.64 63 197927 10705 79535693
Soft tissue injury 17.72 9.64 22 197968 1759 79544639
Obsessive-compulsive personality disorder 17.72 9.64 8 197982 127 79546271
Bipolar I disorder 17.60 9.64 24 197966 2105 79544293
Barotrauma 17.57 9.64 9 197981 191 79546207
Haemophagocytic lymphohistiocytosis 17.50 9.64 17 197973 21820 79524578
Foreign body in reproductive tract 17.47 9.64 14 197976 657 79545741
Epstein-Barr virus infection 17.37 9.64 7 197983 14409 79531989
Self-medication 17.37 9.64 39 197951 5093 79541305
Palmar-plantar erythrodysaesthesia syndrome 17.36 9.64 35 197955 33099 79513299
Speech disorder 17.26 9.64 209 197781 54236 79492162
Carcinoid syndrome 17.16 9.64 9 197981 201 79546197
Dysarthria 17.05 9.64 249 197741 67373 79479025
Parkinsonian gait 17.02 9.64 16 197974 932 79545466
Graft versus host disease 16.99 9.64 8 197982 15018 79531380
Breast swelling 16.97 9.64 19 197971 1361 79545037
Grandiosity 16.91 9.64 13 197977 574 79545824
Accidental overdose 16.76 9.64 161 197829 39420 79506978
Liver injury 16.63 9.64 78 197912 56536 79489862
Drug withdrawal syndrome neonatal 16.63 9.64 10 197980 293 79546105
Pleural effusion 16.60 9.64 257 197733 145005 79401393
Retrograde amnesia 16.56 9.64 13 197977 592 79545806
Hypophosphataemia 16.55 9.64 15 197975 19898 79526500
Respiratory failure 16.55 9.64 333 197657 180578 79365820
Sputum culture 16.54 9.64 9 197981 217 79546181
Adverse event 16.52 9.64 85 197905 60129 79486269
Gallbladder disorder 16.50 9.64 93 197897 19247 79527151
Large intestine anastomosis 16.36 9.64 7 197983 97 79546301
Gynaecomastia 16.31 9.64 49 197941 7632 79538766
Compulsions 16.25 9.64 11 197979 397 79546001
Drug-induced liver injury 16.14 9.64 97 197893 66020 79480378
Trunk injury 16.11 9.64 5 197985 25 79546373
Parosmia 16.10 9.64 46 197944 6968 79539430
Kidney transplant rejection 16.03 9.64 3 197987 10243 79536155
Basal cell carcinoma 15.97 9.64 44 197946 37331 79509067
Angina pectoris 15.96 9.64 70 197920 51662 79494736
Intermenstrual bleeding 15.92 9.64 41 197949 5843 79540555
Cyclic vomiting syndrome 15.92 9.64 7 197983 104 79546294
Decreased interest 15.91 9.64 31 197959 3666 79542732
Neoplasm progression 15.91 9.64 70 197920 51612 79494786
Nausea 15.80 9.64 2654 195336 954542 78591856
Abortion spontaneous 15.59 9.64 126 197864 29381 79517017
Partner stress 15.56 9.64 10 197980 330 79546068
Neoplasm malignant 15.50 9.64 35 197955 31775 79514623
Cerebral thrombosis 15.49 9.64 24 197966 2363 79544035
Stoma obstruction 15.39 9.64 9 197981 250 79546148
Reactive psychosis 15.31 9.64 4 197986 9 79546389
Electrocardiogram abnormal 15.30 9.64 82 197908 16655 79529743
Normochromic normocytic anaemia 15.21 9.64 48 197942 7679 79538719
Imprisonment 15.20 9.64 12 197978 551 79545847
Hemianopia 15.08 9.64 20 197970 1708 79544690
Sleep talking 15.07 9.64 16 197974 1080 79545318
Anterograde amnesia 15.04 9.64 13 197977 678 79545720
Abnormal clotting factor 15 9.64 8 197982 185 79546213
Weight increased 14.99 9.64 837 197153 276549 79269849
Cellulitis 14.94 9.64 186 197804 108874 79437524
Drug screen false positive 14.91 9.64 16 197974 1093 79545305
Respiratory disorder 14.89 9.64 59 197931 44797 79501601
Wheezing 14.87 9.64 202 197788 116462 79429936
Rectal ulcer 14.86 9.64 22 197968 2082 79544316
Brain stem haematoma 14.81 9.64 7 197983 124 79546274
Personality disorder 14.79 9.64 41 197949 6105 79540293
Bladder cancer 14.75 9.64 16 197974 19510 79526888
Skin dystrophy 14.72 9.64 6 197984 73 79546325
Unresponsive to stimuli 14.69 9.64 207 197783 55581 79490817
Cerebellar syndrome 14.64 9.64 38 197952 5442 79540956
Focal dyscognitive seizures 14.57 9.64 29 197961 3483 79542915
Ejection fraction decreased 14.55 9.64 41 197949 34536 79511862
Coma scale abnormal 14.49 9.64 51 197939 8627 79537771
Drug eruption 14.45 9.64 58 197932 43877 79502521
Flight of ideas 14.44 9.64 14 197976 848 79545550
Autonomic nervous system imbalance 14.37 9.64 34 197956 4596 79541802
Pneumonia fungal 14.25 9.64 5 197985 11205 79535193
Spinal cord oedema 14.20 9.64 10 197980 385 79546013
Myositis 14.15 9.64 16 197974 19152 79527246
Neurotoxicity 14.10 9.64 38 197952 32480 79513918
Palpitations 14.10 9.64 413 197577 126197 79420201
Gastrointestinal procedural complication 14.05 9.64 8 197982 211 79546187
Oesophageal carcinoma 13.99 9.64 5 197985 11079 79535319
Neuromyelitis optica spectrum disorder 13.95 9.64 15 197975 1027 79545371
Ventricular dyskinesia 13.91 9.64 10 197980 398 79546000
Impaired driving ability 13.90 9.64 37 197953 5378 79541020
Ocular hypertension 13.90 9.64 18 197972 1502 79544896
Haematoma 13.88 9.64 194 197796 52001 79494397
Diarrhoea 13.84 9.64 1946 196044 878543 78667855
Stress 13.82 9.64 276 197714 79336 79467062
Left ventricle outflow tract obstruction 13.80 9.64 10 197980 403 79545995
Belligerence 13.80 9.64 9 197981 305 79546093
Aphasia 13.79 9.64 177 197813 46555 79499843
Inappropriate affect 13.75 9.64 18 197972 1518 79544880
Leukopenia 13.70 9.64 205 197785 116308 79430090
Hyperventilation 13.69 9.64 47 197943 7852 79538546
Complication of device removal 13.67 9.64 30 197960 3859 79542539
Electrocardiogram QT interval abnormal 13.64 9.64 9 197981 311 79546087
Osteonecrosis of jaw 13.64 9.64 58 197932 43168 79503230
Total lung capacity abnormal 13.50 9.64 8 197982 228 79546170
Freezing phenomenon 13.50 9.64 20 197970 1894 79544504
Device related infection 13.47 9.64 42 197948 34252 79512146
Extradural haematoma 13.47 9.64 25 197965 2851 79543547
Skin necrosis 13.46 9.64 15 197975 18072 79528326
Hot flush 13.41 9.64 201 197789 54676 79491722
Urinary incontinence 13.39 9.64 158 197832 40751 79505647
Joint hyperextension 13.36 9.64 9 197981 322 79546076
Periorbital inflammation 13.36 9.64 6 197984 94 79546304
Rash maculo-papular 13.30 9.64 83 197907 55995 79490403
Apnoea 13.30 9.64 61 197929 11643 79534755
Caesarean section 13.27 9.64 64 197926 12471 79533927
Compulsive shopping 13.19 9.64 13 197977 803 79545595
Peripheral sensory neuropathy 13.18 9.64 8 197982 13025 79533373
Sternal fracture 13.13 9.64 23 197967 2507 79543891
Hypercalcaemia 13.11 9.64 50 197940 38380 79508018
Schizoaffective disorder 13.09 9.64 21 197969 2131 79544267
Inhibitory drug interaction 13.07 9.64 32 197958 4421 79541977
Ovarian vein thrombosis 13.05 9.64 5 197985 51 79546347
Product substitution error 13.05 9.64 5 197985 51 79546347
Cardiac arrest 13.05 9.64 537 197453 171559 79374839
Gastrointestinal disorder 13.03 9.64 219 197771 121986 79424412
Hypogammaglobulinaemia 13.03 9.64 8 197982 12943 79533455
Hyperphagia 12.99 9.64 23 197967 2529 79543869
Joint range of motion decreased 12.90 9.64 41 197949 33241 79513157
Prostate cancer 12.89 9.64 41 197949 33227 79513171
Cytokine release syndrome 12.83 9.64 46 197944 35952 79510446
Electroencephalogram abnormal 12.83 9.64 36 197954 5398 79541000
Priapism 12.82 9.64 32 197958 4473 79541925
Anal incontinence 12.72 9.64 83 197907 18085 79528313
Cholangitis 12.70 9.64 8 197982 12768 79533630
Amenorrhoea 12.67 9.64 45 197945 7647 79538751
Hypernatraemia 12.67 9.64 70 197920 14381 79532017
Psychomotor skills impaired 12.66 9.64 35 197955 5202 79541196
Menometrorrhagia 12.64 9.64 12 197978 708 79545690
Rabbit syndrome 12.61 9.64 9 197981 354 79546044
Anaphylactic reaction 12.56 9.64 140 197850 83603 79462795
Nephrotic syndrome 12.56 9.64 6 197984 11168 79535230
Flat affect 12.53 9.64 20 197970 2021 79544377
Metastases to lung 12.52 9.64 16 197974 18147 79528251
Attention-seeking behaviour 12.51 9.64 6 197984 110 79546288
Hypermetropia 12.50 9.64 10 197980 468 79545930
Psoriasis 12.50 9.64 301 197689 89286 79457112
Pneumonitis 12.49 9.64 94 197896 60766 79485632
Alcohol poisoning 12.44 9.64 33 197957 4788 79541610
Bacteraemia 12.33 9.64 41 197949 32783 79513615
Brain injury 12.33 9.64 59 197931 11458 79534940
Victim of crime 12.32 9.64 10 197980 478 79545920
Endometrial disorder 12.22 9.64 11 197979 606 79545792
Bone swelling 12.22 9.64 18 197972 1696 79544702
Mucormycosis 12.19 9.64 3 197987 8466 79537932
Mood altered 12.18 9.64 81 197909 17766 79528632
Gastric cancer 12.17 9.64 5 197985 10174 79536224
Intraventricular haemorrhage 12.15 9.64 33 197957 4854 79541544
Cytopenia 12.04 9.64 20 197970 20363 79526035
Cough 12.03 9.64 767 197223 366022 79180376
Superior sagittal sinus thrombosis 12 9.64 14 197976 1049 79545349
Illusion 12 9.64 18 197972 1723 79544675
Balance disorder 11.99 9.64 326 197664 98531 79447867
Genital hypoaesthesia 11.99 9.64 7 197983 194 79546204
Disorganised speech 11.98 9.64 20 197970 2097 79544301
Dysgeusia 11.94 9.64 204 197786 56973 79489425
Sperm concentration decreased 11.90 9.64 5 197985 66 79546332
Cytotoxic oedema 11.89 9.64 9 197981 388 79546010
Laryngectomy 11.88 9.64 4 197986 27 79546371
Intensive care 11.85 9.64 14 197976 1063 79545335
Arthritis bacterial 11.80 9.64 4 197986 9162 79537236
Cataract 11.80 9.64 98 197892 62022 79484376
Appendicitis 11.74 9.64 21 197969 20773 79525625
Gambling 11.74 9.64 8 197982 292 79546106
Anticholinergic syndrome 11.73 9.64 27 197963 3584 79542814
Anti-actin antibody positive 11.72 9.64 3 197987 6 79546392
Retinal ischaemia 11.72 9.64 12 197978 776 79545622
Wound healing normal 11.72 9.64 3 197987 6 79546392
Inflammatory marker increased 11.72 9.64 6 197984 10734 79535664
Hepatitis chronic active 11.70 9.64 7 197983 203 79546195
Postural orthostatic tachycardia syndrome 11.66 9.64 13 197977 927 79545471
Polyarthritis 11.64 9.64 8 197982 12194 79534204
Electrocardiogram U wave present 11.64 9.64 6 197984 129 79546269
Hypercholesterolaemia 11.59 9.64 25 197965 23070 79523328
Formication 11.58 9.64 33 197957 4990 79541408
Diffuse large B-cell lymphoma 11.55 9.64 8 197982 12141 79534257
Female orgasmic disorder 11.52 9.64 4 197986 30 79546368
False positive investigation result 11.49 9.64 14 197976 1098 79545300
Ejaculation disorder 11.45 9.64 10 197980 529 79545869
Bile acid malabsorption 11.43 9.64 7 197983 212 79546186
Extensor plantar response 11.39 9.64 18 197972 1803 79544595
Lung consolidation 11.36 9.64 4 197986 8943 79537455
Hypopnoea 11.32 9.64 34 197956 5295 79541103
Jaundice cholestatic 11.31 9.64 7 197983 11277 79535121
Nephropathy 11.30 9.64 5 197985 9733 79536665
Polydipsia 11.19 9.64 39 197951 6566 79539832
Pelvic pain 11.19 9.64 64 197926 13317 79533081
Increased appetite 11.16 9.64 59 197931 11919 79534479
Obesity 11.16 9.64 47 197943 35078 79511320
Retching 11.16 9.64 78 197912 17389 79529009
Toxic epidermal necrolysis 11.09 9.64 65 197925 44516 79501882
Gingival pain 11.05 9.64 48 197942 8950 79537448
Sickle cell anaemia with crisis 11.03 9.64 3 197987 7919 79538479
Drug dependence 11.03 9.64 152 197838 40617 79505781
Respiratory tract infection 11.01 9.64 176 197814 48513 79497885
Burnout syndrome 10.92 9.64 8 197982 328 79546070
Carboxyhaemoglobin increased 10.88 9.64 4 197986 36 79546362
Ulcer 10.88 9.64 38 197952 29934 79516464
Hypokalaemia 10.81 9.64 449 197541 143591 79402807
Homicide 10.77 9.64 14 197976 1172 79545226
Delusional disorder, erotomanic type 10.69 9.64 4 197986 38 79546360
Lactation disorder 10.68 9.64 7 197983 239 79546159
Optic atrophy 10.59 9.64 18 197972 1915 79544483
Enthesopathy 10.57 9.64 8 197982 11600 79534798
Blood pressure diastolic decreased 10.51 9.64 39 197951 30177 79516221
Normal newborn 10.49 9.64 40 197950 7032 79539366
Suture rupture 10.49 9.64 10 197980 593 79545805
Posterior reversible encephalopathy syndrome 10.45 9.64 32 197958 26249 79520149
Female sexual dysfunction 10.42 9.64 4 197986 41 79546357
Coronary artery disease 10.40 9.64 108 197882 65366 79481032
Eosinophil count abnormal 10.39 9.64 11 197979 740 79545658
Atrial flutter 10.37 9.64 24 197966 21601 79524797
Idiopathic orbital inflammation 10.31 9.64 7 197983 254 79546144
Urinary tract infection staphylococcal 10.24 9.64 12 197978 903 79545495
Merycism 10.23 9.64 7 197983 257 79546141
Creatinine urine decreased 10.23 9.64 7 197983 257 79546141
Functional residual capacity increased 10.21 9.64 5 197985 96 79546302
COVID-19 pneumonia 10.19 9.64 37 197953 28812 79517586
Pseudomonas infection 10.18 9.64 23 197967 20880 79525518
Back pain 10.16 9.64 635 197355 303545 79242853
Gastrointestinal haemorrhage 10.15 9.64 284 197706 147435 79398963
Sialoadenitis 10.14 9.64 18 197972 1983 79544415
Stoma site discharge 10.09 9.64 19 197971 2190 79544208
Nystagmus 10.08 9.64 50 197940 9854 79536544
Erection increased 10.05 9.64 8 197982 372 79546026
Cerebellar haematoma 10.04 9.64 10 197980 626 79545772
Blood urea nitrogen/creatinine ratio decreased 10.03 9.64 5 197985 100 79546298
Venous angioma of brain 10.02 9.64 4 197986 46 79546352
Oedema peripheral 10 9.64 518 197472 251770 79294628
Cytarabine syndrome 9.99 9.64 5 197985 101 79546297
Staring 9.98 9.64 21 197969 2624 79543774
Nuchal rigidity 9.98 9.64 13 197977 1091 79545307
Myelodysplastic syndrome 9.97 9.64 40 197950 30261 79516137
Angina unstable 9.97 9.64 16 197974 16511 79529887
Gout 9.94 9.64 30 197960 24719 79521679
Therapeutic response unexpected 9.91 9.64 84 197906 19862 79526536
Taste disorder 9.85 9.64 15 197975 15808 79530590
Food craving 9.85 9.64 16 197974 1641 79544757
External ear cellulitis 9.84 9.64 7 197983 274 79546124
Blood alcohol increased 9.81 9.64 14 197976 1281 79545117
Femur fracture 9.81 9.64 56 197934 38596 79507802
Cognitive disorder 9.77 9.64 235 197755 69691 79476707
Hyperkalaemia 9.74 9.64 213 197777 114185 79432213
Coordination abnormal 9.74 9.64 75 197915 17237 79529161
Economic problem 9.73 9.64 19 197971 2251 79544147
Cardiac failure chronic 9.73 9.64 8 197982 11127 79535271
Breast cancer stage II 9.69 9.64 4 197986 8116 79538282
Colitis 9.68 9.64 126 197864 73181 79473217

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Human herpesvirus 6 infection 34.80 32.07 15 835 45 88897

Pharmacologic Action:

SourceCodeDescription
ATC N06AB10 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D017367 Selective Serotonin Reuptake Inhibitors
MeSH PA D018490 Serotonin Agents
FDA EPC N0000175696 Serotonin Reuptake Inhibitor
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:76779 post-proline endopeptidase inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Major depressive disorder indication 370143000
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Obsessive-compulsive disorder off-label use 191736004 DOID:10933
Menopausal flushing off-label use 198436008
Panic disorder off-label use 371631005 DOID:594
Suicidal thoughts contraindication 6471006
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Upper gastrointestinal hemorrhage contraindication 37372002
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Heart disease contraindication 56265001 DOID:114
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Epilepsy contraindication 84757009 DOID:1826
Hyponatremia contraindication 89627008
Disease of liver contraindication 235856003 DOID:409
Serotonin syndrome contraindication 371089000
Myocardial infarction in recovery phase contraindication 418044006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 10MG BASE LEXAPRO ABBVIE N021323 Aug. 14, 2002 RX TABLET ORAL May 12, 2026 NEW PATIENT POPULATION
EQ 20MG BASE LEXAPRO ABBVIE N021323 Aug. 14, 2002 RX TABLET ORAL May 12, 2026 NEW PATIENT POPULATION
EQ 5MG BASE LEXAPRO ABBVIE N021323 Aug. 14, 2002 RX TABLET ORAL May 12, 2026 NEW PATIENT POPULATION
EQ 5MG BASE/5ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** LEXAPRO ABBVIE N021365 Nov. 27, 2002 DISCN SOLUTION ORAL May 12, 2026 NEW PATIENT POPULATION

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Ki 8.96 WOMBAT-PK CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 5.19 PDSP
5-hydroxytryptamine receptor 2C GPCR Ki 5.60 PDSP
Alpha-1A adrenergic receptor GPCR Ki 5.41 PDSP
Histamine H1 receptor GPCR Ki 5.71 PDSP
Muscarinic acetylcholine receptor M1 GPCR Ki 5.91 PDSP
Sodium-dependent serotonin transporter Transporter Ki 9.05 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 5.09 CHEMBL
Transporter Transporter Ki 4.98 CHEMBL

External reference:

IDSource
4024285 VUID
N0000022289 NUI
D02567 KEGG_DRUG
219861-08-2 SECONDARY_CAS_RN
4021356 VANDF
4024285 VANDF
C1099456 UMLSCUI
CHEBI:36791 CHEBI
CHEMBL1508 ChEMBL_ID
DB01175 DRUGBANK_ID
CHEMBL1200322 ChEMBL_ID
D000089983 MESH_DESCRIPTOR_UI
146570 PUBCHEM_CID
7177 IUPHAR_LIGAND_ID
7953 INN_ID
4O4S742ANY UNII
321988 RXNORM
158618 MMSL
16927 MMSL
187848 MMSL
d04812 MMSL
009709 NDDF
009710 NDDF
395246009 SNOMEDCT_US
400447003 SNOMEDCT_US
412384000 SNOMEDCT_US
68P PDB_CHEM_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Escitalopram Oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0121-0852 SOLUTION 10 mg ORAL ANDA 36 sections
Escitalopram Oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0121-0852 SOLUTION 10 mg ORAL ANDA 36 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2005 TABLET, FILM COATED 5 mg ORAL NDA 34 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2005 TABLET, FILM COATED 5 mg ORAL NDA 34 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2005 TABLET, FILM COATED 5 mg ORAL NDA 34 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2010 TABLET, FILM COATED 10 mg ORAL NDA 34 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2010 TABLET, FILM COATED 10 mg ORAL NDA 34 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2010 TABLET, FILM COATED 10 mg ORAL NDA 34 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2020 TABLET, FILM COATED 20 mg ORAL NDA 34 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2020 TABLET, FILM COATED 20 mg ORAL NDA 34 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2020 TABLET, FILM COATED 20 mg ORAL NDA 34 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2101 SOLUTION 5 mg ORAL NDA 34 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2101 SOLUTION 5 mg ORAL NDA 34 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2101 SOLUTION 5 mg ORAL NDA 34 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-7953 TABLET 5 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-7954 TABLET 10 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-7955 TABLET 20 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8348 TABLET, FILM COATED 5 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8349 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8350 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8365 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8366 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8475 TABLET, FILM COATED 5 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8476 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8477 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6426 TABLET 10 mg ORAL ANDA 32 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6426 TABLET 10 mg ORAL ANDA 32 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6426 TABLET 10 mg ORAL ANDA 32 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6427 TABLET 20 mg ORAL ANDA 32 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6427 TABLET 20 mg ORAL ANDA 32 sections