escitalopram 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1053	128196-01-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: escitalopram (+)-(S)-Citalopram (+)-Citalopram (S)-Citalopram S-(+)-Citalopram seroplex escitalopram oxalate	Molecular weight: 324.40 Formula: C20H21FN2O CLOGP: 3.13 LIPINSKI: 0 HAC: 3 HDO: 0 TPSA: 36.26 ALOGS: -4.74 ROTB: 5 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

escitalopram
(+)-(S)-Citalopram
(+)-Citalopram
(S)-Citalopram
S-(+)-Citalopram
seroplex
escitalopram oxalate

Molecular weight: 324.40
Formula: C20H21FN2O
CLOGP: 3.13
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 36.26
ALOGS: -4.74
ROTB: 5

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
10	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	8 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.88 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

Date	Agency	Company	Orphan
Aug. 14, 2002	FDA	FOREST LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Suicide attempt	472.04	9.51	674	151096	51058	50402296
Suicidal ideation	463.91	9.51	693	151077	54692	50398662
Electrocardiogram QT prolonged	447.18	9.51	658	151112	51228	50402126
Intentional overdose	444.07	9.51	725	151045	61779	50391575
Serotonin syndrome	370.95	9.51	413	151357	24300	50429054
Pemphigus	338.81	9.51	4	151766	120162	50333192
Sopor	317.05	9.51	343	151427	19536	50433818
Anxiety	279.13	9.51	1163	150607	176443	50276911
Contraindicated product administered	277.04	9.51	55	151715	148903	50304451
Systemic lupus erythematosus	274.28	9.51	46	151724	140576	50312778
Synovitis	266.38	9.51	30	151740	123835	50329519
Completed suicide	256.43	9.51	924	150846	130965	50322389
Hand deformity	250.14	9.51	12	151758	100187	50353167
Drug interaction	246.30	9.51	1217	150553	198404	50254950
Overdose	242.03	9.51	753	151017	98974	50354380
Depression	238.89	9.51	1056	150714	164367	50288987
Somnolence	231.88	9.51	1000	150770	153985	50299369
Treatment failure	228.03	9.51	65	151705	137572	50315782
Arthropathy	224.84	9.51	96	151674	157810	50295544
Glossodynia	218.39	9.51	41	151729	115528	50337826
Joint swelling	211.24	9.51	255	151515	245031	50208323
Drug intolerance	201.44	9.51	216	151554	218888	50234466
Drug ineffective	182.07	9.51	1580	150190	817753	49635601
Swelling	174.82	9.51	207	151563	200665	50252689
Tremor	166.09	9.51	734	151036	114169	50339185
Intentional self-injury	163.87	9.51	268	151502	22844	50430510
Alopecia	159.67	9.51	308	151462	244739	50208615
Infusion related reaction	155.95	9.51	167	151603	169390	50283964
Product substitution issue	153.62	9.51	200	151570	13857	50439497
Wound	152.65	9.51	63	151707	105731	50347623
Hyponatraemia	146.46	9.51	624	151146	95515	50357839
Pericarditis	146.34	9.51	29	151741	78660	50374694
Rheumatoid arthritis	135.04	9.51	251	151519	202299	50251055
Rheumatoid factor positive	134.88	9.51	3	151767	49856	50403498
Coma	131.94	9.51	423	151347	56456	50396898
Agitation	127.47	9.51	401	151369	52983	50400371
Inappropriate antidiuretic hormone secretion	125.33	9.51	175	151595	12968	50440386
Duodenal ulcer perforation	122.39	9.51	3	151767	45608	50407746
Helicobacter infection	120.72	9.51	7	151763	49695	50403659
Akathisia	115.74	9.51	133	151637	8096	50445258
Abdominal discomfort	110.75	9.51	342	151428	231299	50222055
Lower respiratory tract infection	110.40	9.51	75	151695	95126	50358228
Therapeutic product effect decreased	103.21	9.51	155	151615	135895	50317459
Tardive dyskinesia	101.29	9.51	117	151653	7162	50446192
Peripheral swelling	99.89	9.51	302	151468	205634	50247720
Seizure	97.86	9.51	647	151123	117227	50336127
Arthralgia	97.29	9.51	845	150925	437857	50015497
Mania	96.21	9.51	140	151630	10776	50442578
Withdrawal syndrome	96.19	9.51	182	151588	17408	50435946
Hepatic enzyme increased	92.61	9.51	169	151601	137211	50316143
Rash	92.02	9.51	854	150916	436617	50016737
Fall	91.53	9.51	1461	150309	333471	50119883
Maternal exposure during pregnancy	90.51	9.51	217	151553	159561	50293793
Poisoning deliberate	88.68	9.51	114	151656	7798	50445556
Drug hypersensitivity	88.67	9.51	419	151351	250591	50202763
Folliculitis	88.17	9.51	8	151762	39217	50414137
Muscle injury	87.81	9.51	6	151764	37105	50416249
Hypersensitivity	86.46	9.51	342	151428	214819	50238535
Panic attack	86.46	9.51	184	151586	19158	50434196
Irritability	85.58	9.51	232	151538	28194	50425160
Torsade de pointes	82.21	9.51	136	151634	11699	50441655
Impaired healing	80.87	9.51	55	151715	69731	50383623
Discomfort	80.72	9.51	125	151645	108255	50345099
Muscle rigidity	79.38	9.51	121	151649	9708	50443646
Dyskinesia	77.57	9.51	221	151549	27640	50425714
Drug abuse	75.82	9.51	368	151402	59478	50393876
Sympathomimetic effect	75.07	9.51	20	151750	38	50453316
Infection	72.62	9.51	270	151500	172684	50280670
Stomatitis	72.53	9.51	120	151650	101224	50352130
Disturbance in attention	72.36	9.51	232	151538	30954	50422400
Crying	72.16	9.51	177	151593	20239	50433115
Loss of consciousness	69.90	9.51	544	151226	103809	50349545
Mental disorder	68.74	9.51	182	151588	21809	50431545
Insomnia	68.14	9.51	813	150957	174052	50279302
Mydriasis	67.05	9.51	117	151653	10510	50442844
Tonsillar ulcer	66.54	9.51	27	151743	264	50453090
Long QT syndrome	65.33	9.51	61	151709	2906	50450448
Psychotic disorder	64.64	9.51	177	151593	21635	50431719
C-reactive protein abnormal	64.35	9.51	5	151765	27804	50425550
Extrapyramidal disorder	63.39	9.51	121	151649	11649	50441705
Febrile neutropenia	63.28	9.51	123	151647	97544	50355810
Paranoia	62.80	9.51	112	151658	10236	50443118
Blister	62.19	9.51	100	151670	85318	50368036
Neuroleptic malignant syndrome	61.90	9.51	116	151654	11014	50442340
Restlessness	61.82	9.51	191	151579	24982	50428372
Stiff person syndrome	61.78	9.51	24	151746	207	50453147
Hyperhidrosis	60.33	9.51	467	151303	88959	50364395
Product use issue	59.74	9.51	238	151532	149237	50304117
Sepsis	58.78	9.51	203	151567	132722	50320632
Pain	58.67	9.51	1307	150463	577596	49875758
Death	58.07	9.51	660	151110	324719	50128635
Toxicity to various agents	57.56	9.51	926	150844	211573	50241781
Hallucination, auditory	57.42	9.51	110	151660	10618	50442736
Pregnancy	57.16	9.51	207	151563	29370	50423984
Galactorrhoea	55.46	9.51	62	151708	3661	50449693
Cholecystitis chronic	55.31	9.51	102	151668	9567	50443787
Dizziness	55.21	9.51	1394	150376	344975	50108379
Drug withdrawal syndrome neonatal	54.94	9.51	45	151725	1796	50451558
Emotional distress	54.89	9.51	200	151570	28463	50424891
Confusional state	54.45	9.51	821	150949	185107	50268247
Depressed mood	54.22	9.51	224	151546	33799	50419555
Off label use	53.64	9.51	1052	150718	473374	49979980
Apathy	52.78	9.51	87	151683	7461	50445893
Depressed level of consciousness	52.42	9.51	300	151470	51653	50401701
Lower respiratory tract infection viral	50.55	9.51	29	151741	638	50452716
Hypertonia	50.54	9.51	61	151709	3912	50449442
C-reactive protein increased	50.12	9.51	76	151694	66398	50386956
Hyperreflexia	48.57	9.51	68	151702	5050	50448304
Multiple sclerosis relapse	47.97	9.51	255	151515	42709	50410645
Suicidal behaviour	47.61	9.51	46	151724	2288	50451066
Oculogyric crisis	46.87	9.51	37	151733	1400	50451954
Amnesia	46.62	9.51	250	151520	42010	50411344
Electrocardiogram QRS complex prolonged	46.31	9.51	68	151702	5276	50448078
Miosis	45.84	9.51	74	151696	6236	50447118
Delusion	45.46	9.51	99	151671	10470	50442884
Mobility decreased	44.90	9.51	109	151661	79839	50373515
Feeling abnormal	44.76	9.51	574	151196	124918	50328436
Psychomotor hyperactivity	43.33	9.51	90	151680	9211	50444143
Bruxism	42.52	9.51	49	151721	2991	50450363
Hip arthroplasty	42.46	9.51	19	151751	30410	50422944
Pulmonary embolism	42.30	9.51	479	151291	101225	50352129
Foetal exposure during pregnancy	41.93	9.51	178	151592	27181	50426173
Hallucination	41.68	9.51	261	151509	46396	50406958
Congenital absence of vertebra	41.22	9.51	12	151758	36	50453318
Sinus bradycardia	41.09	9.51	109	151661	13074	50440280
Inflammation	41.07	9.51	67	151703	56845	50396509
Drug withdrawal syndrome	40.65	9.51	166	151604	24915	50428439
Irritable bowel syndrome	40.55	9.51	57	151713	51384	50401970
Aggression	40.14	9.51	147	151623	20969	50432385
Abnormal behaviour	40.06	9.51	140	151630	19518	50433836
Deep vein thrombosis	39.96	9.51	365	151405	72939	50380415
Lip ulceration	39.53	9.51	37	151733	1768	50451586
Pyrexia	39.37	9.51	855	150915	379348	50074006
Reversible airways obstruction	39.29	9.51	29	151741	991	50452363
Knee arthroplasty	39.24	9.51	30	151740	35816	50417538
Bronchial secretion retention	39.02	9.51	34	151736	1479	50451875
Ill-defined disorder	38.82	9.51	65	151705	54589	50398765
Memory impairment	38.72	9.51	386	151384	78974	50374380
Sinusitis	38.32	9.51	327	151443	170231	50283123
Hallucination, visual	38.13	9.51	123	151647	16459	50436895
Reversible cerebral vasoconstriction syndrome	38.12	9.51	39	151731	2080	50451274
Psychomotor retardation	37.91	9.51	49	151721	3369	50449985
Acute kidney injury	37.79	9.51	470	151300	227588	50225766
Nasopharyngitis	37.71	9.51	383	151387	192544	50260810
Anger	37.68	9.51	96	151674	11237	50442117
Red blood cell sedimentation rate abnormal	37.64	9.51	3	151767	16340	50437014
Neutropenia	37.26	9.51	275	151495	147690	50305664
Abnormal dreams	37.15	9.51	85	151685	9292	50444062
Pyramidal tract syndrome	37.07	9.51	19	151751	331	50453023
Vital capacity decreased	36.42	9.51	27	151743	929	50452425
Muscle twitching	35.97	9.51	115	151655	15316	50438038
Mucosal inflammation	35.25	9.51	41	151729	40101	50413253
Clonus	34.57	9.51	52	151718	4123	50449231
Adjustment disorder with mixed anxiety and depressed mood	34.34	9.51	12	151758	74	50453280
Anhedonia	34.11	9.51	83	151687	9441	50443913
Mental status changes	33.71	9.51	205	151565	36067	50417287
Cardiac arrest	33.00	9.51	390	151380	83261	50370093
Syncope	32.95	9.51	462	151308	102540	50350814
Pneumocystis jirovecii pneumonia	32.93	9.51	3	151767	14660	50438694
Multiple sclerosis	32.71	9.51	135	151635	20358	50432996
Hostility	32.42	9.51	33	151737	1749	50451605
Small for dates baby	32.42	9.51	46	151724	3459	50449895
Nightmare	32.29	9.51	114	151656	15972	50437382
Bundle branch block left	32.26	9.51	63	151707	6167	50447187
Osteoporosis	32.22	9.51	53	151717	44826	50408528
Arthritis	31.59	9.51	143	151627	86578	50366776
Slow speech	31.44	9.51	28	151742	1254	50452100
Alcoholism	31.31	9.51	31	151739	1589	50451765
Self-injurious ideation	31.30	9.51	36	151734	2193	50451161
Multiple organ dysfunction syndrome	31.22	9.51	65	151705	50272	50403082
Renal impairment	31.15	9.51	119	151651	75542	50377812
Pancytopenia	30.95	9.51	138	151632	83892	50369462
Subdural hygroma	30.81	9.51	15	151755	233	50453121
Tachycardia	30.52	9.51	444	151326	99319	50354035
Bradyphrenia	30.40	9.51	61	151709	6091	50447263
Disease progression	30.38	9.51	166	151604	95700	50357654
Libido increased	30.19	9.51	27	151743	1216	50452138
Activation syndrome	30.11	9.51	14	151756	195	50453159
Derealisation	30.03	9.51	25	151745	1021	50452333
Optic nerve injury	29.24	9.51	19	151751	526	50452828
Affective disorder	28.81	9.51	54	151716	5127	50448227
Generalised tonic-clonic seizure	28.58	9.51	155	151615	26155	50427199
Homicidal ideation	28.24	9.51	30	151740	1672	50451682
Respiratory arrest	28.14	9.51	170	151600	29839	50423515
Cerebral haematoma	28.03	9.51	41	151729	3170	50450184
Restless legs syndrome	28.00	9.51	108	151662	15789	50437565
Dystonia	27.91	9.51	89	151681	11837	50441517
Congenital pulmonary valve atresia	27.79	9.51	10	151760	68	50453286
Gestational diabetes	27.75	9.51	66	151704	7399	50445955
Dyspnoea	27.41	9.51	1353	150417	546255	49907099
Sputum culture positive	27.22	9.51	27	151743	1387	50451967
Cytomegalovirus infection	27.04	9.51	10	151760	17952	50435402
Skin ulcer	26.98	9.51	40	151730	35278	50418076
Nausea	26.87	9.51	2459	149311	702939	49750415
Sight disability	26.80	9.51	11	151759	111	50453243
Thermohypoaesthesia	26.72	9.51	11	151759	112	50453242
Treatment noncompliance	26.51	9.51	168	151602	29982	50423372
Disorientation	26.00	9.51	189	151581	35295	50418059
Screaming	25.96	9.51	38	151732	2940	50450414
Gun shot wound	25.66	9.51	10	151760	87	50453267
Platelet aggregation inhibition	25.65	9.51	11	151759	125	50453229
Bone marrow failure	25.59	9.51	27	151743	27597	50425757
Morose	25.53	9.51	8	151762	33	50453321
Angle closure glaucoma	25.50	9.51	31	151739	2003	50451351
Obsessive-compulsive disorder	25.40	9.51	40	151730	3300	50450054
Depressive symptom	25.28	9.51	39	151731	3161	50450193
Head injury	25.08	9.51	140	151630	23880	50429474
Gastroschisis	24.89	9.51	13	151757	236	50453118
Tongue biting	24.88	9.51	25	151745	1305	50452049
Behaviour disorder	24.67	9.51	33	151737	2347	50451007
Initial insomnia	24.42	9.51	50	151720	5065	50448289
Musculoskeletal stiffness	24.29	9.51	257	151513	128224	50325130
Euphoric mood	23.47	9.51	43	151727	4012	50449342
Moaning	23.27	9.51	19	151751	755	50452599
Bipolar disorder	23.26	9.51	58	151712	6699	50446655
Sepsis neonatal	23.10	9.51	15	151755	415	50452939
Rheumatoid nodule	23.03	9.51	5	151765	12730	50440624
Hypersomnia	22.97	9.51	99	151671	15215	50438139
Conversion disorder	22.79	9.51	26	151744	1570	50451784
Ventricular dyskinesia	22.69	9.51	10	151760	122	50453232
Dysarthria	22.32	9.51	190	151580	37213	50416141
Large intestine anastomosis	22.31	9.51	7	151763	29	50453325
Bradypnoea	22.26	9.51	36	151734	3038	50450316
Mental impairment	22.18	9.51	83	151687	11961	50441393
Hepatic function abnormal	22.18	9.51	40	151730	32641	50420713
Drug screen positive	22.17	9.51	38	151732	3364	50449990
Adverse drug reaction	21.99	9.51	88	151682	55134	50398220
Nervousness	21.84	9.51	150	151620	27501	50425853
Immobilisation prolonged	21.49	9.51	9	151761	96	50453258
Negative thoughts	21.41	9.51	19	151751	847	50452507
Hyperthermia	21.37	9.51	61	151709	7635	50445719
Sinus tachycardia	21.33	9.51	123	151647	21231	50432123
Myoclonus	21.29	9.51	93	151677	14377	50438977
Pruritus	21.25	9.51	668	151102	282900	50170454
Extradural haematoma	21.23	9.51	25	151745	1562	50451792
Paraesthesia	21.21	9.51	491	151279	119752	50333602
Maternal drugs affecting foetus	21.20	9.51	47	151723	5030	50448324
Head banging	21.13	9.51	14	151756	401	50452953
Neutropenic sepsis	21.09	9.51	8	151762	14139	50439215
Somnambulism	21.04	9.51	46	151724	4878	50448476
Intermenstrual bleeding	20.89	9.51	56	151714	6758	50446596
Osteoarthritis	20.54	9.51	121	151649	68485	50384869
Disseminated intravascular coagulation	20.53	9.51	13	151757	17122	50436232
Emotional disorder	20.51	9.51	80	151690	11756	50441598
Antiphospholipid antibodies	20.50	9.51	10	151760	156	50453198
Pneumonia	20.46	9.51	927	150843	377474	50075880
Sexual dysfunction	20.45	9.51	36	151734	3256	50450098
Blood creatinine increased	20.40	9.51	139	151631	76021	50377333
Bradycardia	20.20	9.51	288	151482	64138	50389216
Pain in extremity	20.15	9.51	644	151126	272221	50181133
Epilepsy	20.11	9.51	122	151648	21445	50431909
Platelet count decreased	20.06	9.51	199	151571	100527	50352827
Postictal state	19.90	9.51	19	151751	931	50452423
Neutrophil count decreased	19.85	9.51	71	151699	45955	50407399
Dysphoria	19.72	9.51	44	151726	4730	50448624
Partner stress	19.55	9.51	12	151758	300	50453054
Cytotoxic oedema	19.51	9.51	9	151761	123	50453231
Bundle branch block right	19.40	9.51	43	151727	4602	50448752
Thinking abnormal	19.37	9.51	68	151702	9499	50443855
Polydipsia	19.20	9.51	34	151736	3090	50450264
Hypervigilance	19.14	9.51	12	151758	312	50453042
Retinal ischaemia	19.10	9.51	12	151758	313	50453041
Cardiogenic shock	19.09	9.51	95	151675	15504	50437850
Post-traumatic neck syndrome	19.06	9.51	26	151744	1884	50451470
Tracheal atresia	18.91	9.51	6	151764	26	50453328
Parkinsonism	18.89	9.51	64	151706	8783	50444571
Libido decreased	18.83	9.51	29	151741	2347	50451007
Bipolar I disorder	18.81	9.51	23	151747	1495	50451859
Band sensation	18.80	9.51	16	151754	674	50452680
Hypertensive cardiomyopathy	18.74	9.51	10	151760	190	50453164
Ocular hypertension	18.69	9.51	17	151753	783	50452571
Foot deformity	18.68	9.51	18	151752	19192	50434162
Rhabdomyolysis	18.63	9.51	189	151581	38838	50414516
Major depression	18.57	9.51	54	151716	6830	50446524
Drowning	18.52	9.51	13	151757	410	50452944
Hepatitis chronic active	18.48	9.51	7	151763	56	50453298
Hyperdynamic left ventricle	18.36	9.51	9	151761	142	50453212
Blood lactic acid	18.34	9.51	8	151762	95	50453259
Cardiac failure	18.33	9.51	143	151627	75897	50377457
Retroplacental haematoma	18.25	9.51	9	151761	144	50453210
Gastrointestinal disorder	18.23	9.51	188	151582	94268	50359086
Learning disorder	18.22	9.51	15	151755	603	50452751
Feeling jittery	18.19	9.51	74	151696	11086	50442268
Hyperventilation	18.17	9.51	46	151724	5363	50447991
Cardio-respiratory arrest	18.15	9.51	244	151526	53648	50399706
Blood prolactin increased	18.11	9.51	33	151737	3066	50450288
Fear	18.08	9.51	89	151681	14460	50438894
Road traffic accident	18.00	9.51	130	151640	24222	50429132
Acute myocardial infarction	17.98	9.51	38	151732	29235	50424119
Product administered to patient of inappropriate age	17.97	9.51	30	151740	2600	50450754
Feeling of despair	17.95	9.51	26	151744	1992	50451362
Amaurosis	17.82	9.51	14	151756	526	50452828
Psychomotor skills impaired	17.51	9.51	26	151744	2038	50451316
Unresponsive to stimuli	17.48	9.51	154	151616	30455	50422899
Biliary dyskinesia	17.30	9.51	29	151741	2521	50450833
Rectal ulcer	17.24	9.51	19	151751	1104	50452250
Injury	17.09	9.51	223	151547	48702	50404652
Hyperphagia	17.05	9.51	22	151748	1510	50451844
Bradykinesia	17.03	9.51	37	151733	3906	50449448
Psoriasis	16.91	9.51	296	151474	68704	50384650
Caesarean section	16.89	9.51	92	151678	15547	50437807
Left ventricle outflow tract obstruction	16.88	9.51	10	151760	234	50453120
Poisoning	16.87	9.51	78	151692	12351	50441003
Bone erosion	16.78	9.51	7	151763	11680	50441674
Vertigo	16.77	9.51	233	151537	51599	50401755
Anaemia	16.73	9.51	604	151166	251852	50201502
Product substitution error	16.71	9.51	5	151765	17	50453337
Cerebral thrombosis	16.65	9.51	22	151748	1546	50451808
Intentional product use issue	16.58	9.51	149	151621	76769	50376585
Barotrauma	16.54	9.51	9	151761	178	50453176
Decreased interest	16.53	9.51	31	151739	2945	50450409
Therapeutic product effect incomplete	16.51	9.51	185	151585	91330	50362024
Heavy menstrual bleeding	16.51	9.51	91	151679	15446	50437908
Colitis microscopic	16.50	9.51	50	151720	6470	50446884
Trunk injury	16.49	9.51	5	151765	18	50453336
Malignant neoplasm progression	16.48	9.51	128	151642	67996	50385358
Sedation	16.46	9.51	152	151618	30458	50422896
Tearfulness	16.39	9.51	35	151735	3652	50449702
Sleep disorder	16.36	9.51	252	151518	57031	50396323
Middle insomnia	16.34	9.51	66	151704	9855	50443499
Impulsive behaviour	16.33	9.51	21	151749	1437	50451917
Balance disorder	16.31	9.51	300	151470	70290	50383064
Oral candidiasis	16.27	9.51	16	151754	16899	50436455
Orgasm abnormal	16.13	9.51	7	151763	82	50453272
Victim of sexual abuse	16.11	9.51	13	151757	508	50452846
Panniculitis	16.08	9.51	3	151767	8500	50444854
Uterine perforation	16.05	9.51	49	151721	6366	50446988
Drug resistance	16.03	9.51	20	151750	18969	50434385
Femur fracture	16.02	9.51	58	151712	37406	50415948
Breast swelling	16.02	9.51	18	151752	1069	50452285
Persecutory delusion	16.00	9.51	27	151743	2360	50450994
Magnetic resonance imaging head abnormal	15.96	9.51	23	151747	1754	50451600
Cogwheel rigidity	15.96	9.51	23	151747	1754	50451600
Hepatitis infectious mononucleosis	15.91	9.51	7	151763	85	50453269
Dermatitis atopic	15.89	9.51	34	151736	3552	50449802
Red blood cell sedimentation rate increased	15.81	9.51	41	151729	29375	50423979
Interstitial lung disease	15.80	9.51	94	151676	53082	50400272
Ventricular fibrillation	15.64	9.51	68	151702	10491	50442863
Respiratory disorder	15.62	9.51	45	151725	31142	50422212
Exercise lack of	15.56	9.51	11	151759	351	50453003
Osteonecrosis of jaw	15.52	9.51	48	151722	32478	50420876
Septic shock	15.49	9.51	104	151666	57071	50396283
Hemianopia	15.44	9.51	16	151754	866	50452488
Self-medication	15.41	9.51	26	151744	2273	50451081
Concussion	15.26	9.51	54	151716	7574	50445780
Dry mouth	15.24	9.51	245	151525	55933	50397421
Gallbladder disorder	15.16	9.51	94	151676	16648	50436706
Orthostatic hypotension	15.16	9.51	145	151625	29336	50424018
Transplant rejection	15.06	9.51	5	151765	9604	50443750
Musculoskeletal pain	15.04	9.51	141	151629	72036	50381318
Congenital diaphragmatic eventration	14.88	9.51	4	151766	8	50453346
Anti-actin antibody positive	14.88	9.51	4	151766	8	50453346
Panic reaction	14.86	9.51	33	151737	3536	50449818
Hypokalaemia	14.80	9.51	357	151413	87635	50365719
Alcohol abuse	14.78	9.51	23	151747	1878	50451476
Tinnitus	14.78	9.51	139	151631	27993	50425361
Hypertension	14.75	9.51	502	151268	210701	50242653
Fibromyalgia	14.73	9.51	77	151693	44901	50408453
Hypocoagulable state	14.65	9.51	16	151754	920	50452434
Carcinoid syndrome	14.59	9.51	7	151763	105	50453249
Transposition of the great vessels	14.54	9.51	8	151762	162	50453192
Prothrombin level increased	14.52	9.51	9	151761	229	50453125
Soft tissue injury	14.51	9.51	20	151750	1464	50451890
Neuromyelitis optica spectrum disorder	14.49	9.51	15	151755	811	50452543
Psychiatric symptom	14.46	9.51	38	151732	4532	50448822
Cellulitis	14.46	9.51	139	151631	70659	50382695
Weight increased	14.41	9.51	742	151028	201149	50252205
Right ventricular dilatation	14.38	9.51	16	151754	940	50452414
Drug dependence	14.33	9.51	105	151665	19654	50433700
Obsessive thoughts	14.27	9.51	12	151758	497	50452857
Bursitis	14.22	9.51	28	151742	22107	50431247
Dissociation	14.16	9.51	25	151745	2266	50451088
Haemoglobin urine	14.14	9.51	7	151763	113	50453241
Alcohol use	13.96	9.51	23	151747	1972	50451382
Cardiac hypertrophy	13.93	9.51	16	151754	973	50452381
Fracture	13.92	9.51	18	151752	16815	50436539
Pupil fixed	13.81	9.51	20	151750	1532	50451822
Flight of ideas	13.80	9.51	10	151760	332	50453022
Stoma site discharge	13.71	9.51	18	151752	1257	50452097
Spinal cord oedema	13.71	9.51	7	151763	121	50453233
Attention-seeking behaviour	13.56	9.51	6	151764	74	50453280
Extensor plantar response	13.52	9.51	17	151753	1137	50452217
Torticollis	13.49	9.51	21	151749	1715	50451639
Wheezing	13.45	9.51	120	151650	61927	50391427
Myocardial infarction	13.42	9.51	187	151583	88840	50364514
Focal dyscognitive seizures	13.39	9.51	27	151743	2705	50450649
White blood cell count decreased	13.36	9.51	258	151512	116464	50336890
Brain injury	13.28	9.51	44	151726	5970	50447384
Dextrocardia	13.28	9.51	4	151766	14	50453340
Vision blurred	13.20	9.51	319	151451	78328	50375026
Lethargy	13.19	9.51	215	151555	49217	50404137
Staring	13.13	9.51	19	151751	1455	50451899
Cerebellar syndrome	13.10	9.51	30	151740	3281	50450073
Atrioventricular block	13.08	9.51	46	151724	6432	50446922
Pulmonary contusion	13.06	9.51	4	151766	15	50453339
Cough	13.02	9.51	591	151179	240673	50212681
Colour blindness	12.99	9.51	9	151761	278	50453076
Disinhibition	12.95	9.51	14	151756	796	50452558
Bundle branch block	12.92	9.51	14	151756	798	50452556
Mood swings	12.87	9.51	87	151683	15867	50437487
Apnoea	12.82	9.51	48	151722	6918	50446436
Joint hyperextension	12.76	9.51	9	151761	286	50453068
Substance abuse	12.75	9.51	34	151736	4090	50449264
Superior sagittal sinus thrombosis	12.69	9.51	13	151757	694	50452660
Tonsillitis	12.69	9.51	38	151732	4885	50448469
Haemophagocytic lymphohistiocytosis	12.67	9.51	5	151765	8628	50444726
Snoring	12.67	9.51	30	151740	3354	50450000
Ovarian vein thrombosis	12.59	9.51	5	151765	46	50453308
Narrow anterior chamber angle	12.59	9.51	5	151765	46	50453308
Haematotoxicity	12.57	9.51	4	151766	7891	50445463
Suspected suicide	12.56	9.51	40	151730	5317	50448037
Nuchal rigidity	12.42	9.51	12	151758	597	50452757
Anterograde amnesia	12.38	9.51	11	151759	491	50452863
Cerebral arteriovenous malformation haemorrhagic	12.37	9.51	3	151767	3	50453351
Wrong product procured	12.37	9.51	3	151767	3	50453351
Metamyelocyte count increased	12.27	9.51	8	151762	223	50453131
Mucosal ulceration	12.26	9.51	14	151756	846	50452508
Bile acid malabsorption	12.24	9.51	7	151763	153	50453201
Haemorrhagic stroke	12.22	9.51	39	151731	5189	50448165
Immunodeficiency	12.12	9.51	16	151754	14812	50438542
Multimorbidity	11.89	9.51	11	151759	518	50452836
Cor pulmonale acute	11.86	9.51	9	151761	321	50453033
Sleep-related eating disorder	11.80	9.51	13	151757	755	50452599
Social avoidant behaviour	11.80	9.51	26	151744	2771	50450583
Holoprosencephaly	11.68	9.51	4	151766	23	50453331
Creatinine urine decreased	11.66	9.51	7	151763	168	50453186
Migraine	11.64	9.51	302	151468	74978	50378376
Impaired driving ability	11.59	9.51	32	151738	3929	50449425
Gambling disorder	11.53	9.51	16	151754	1178	50452176
Coma scale abnormal	11.53	9.51	36	151734	4735	50448619
Retching	11.51	9.51	72	151698	12790	50440564
Convulsive threshold lowered	11.50	9.51	9	151761	336	50453018
Laryngectomy	11.40	9.51	4	151766	25	50453329
Metastases to bone	11.36	9.51	23	151747	17972	50435382
Choroidal effusion	11.30	9.51	10	151760	444	50452910
Sternal fracture	11.30	9.51	21	151749	1981	50451373
Enterococcus test positive	11.30	9.51	15	151755	1059	50452295
Lung diffusion disorder	11.27	9.51	5	151765	62	50453292
Neonatal respiratory depression	11.27	9.51	5	151765	62	50453292
Poor quality sleep	11.25	9.51	87	151683	16559	50436795
Xerophthalmia	11.17	9.51	9	151761	351	50453003
Atrophy of globe	11.16	9.51	3	151767	6	50453348
Meningocele	11.16	9.51	3	151767	6	50453348
Wound healing normal	11.16	9.51	3	151767	6	50453348
Tonic clonic movements	11.10	9.51	16	151754	1221	50452133
Antipsychotic drug level increased	11.03	9.51	27	151743	3082	50450272
Tachyphrenia	11.02	9.51	16	151754	1229	50452125
Head titubation	10.98	9.51	12	151758	691	50452663
Blood pressure diastolic decreased	10.98	9.51	21	151749	16760	50436594
Sialoadenitis	10.97	9.51	17	151753	1383	50451971
Pulseless electrical activity	10.86	9.51	45	151725	6796	50446558
Aphasia	10.86	9.51	132	151638	28362	50424992
Post concussion syndrome	10.84	9.51	10	151760	469	50452885
Enthesopathy	10.83	9.51	4	151766	7189	50446165
Optic atrophy	10.79	9.51	15	151755	1107	50452247
General physical health deterioration	10.78	9.51	335	151435	142099	50311255
Compulsive shopping	10.77	9.51	12	151758	706	50452648
Menometrorrhagia	10.74	9.51	13	151757	836	50452518
Periorbital haemorrhage	10.67	9.51	5	151765	71	50453283
CSF pressure increased	10.66	9.51	6	151764	127	50453227
Acute myeloid leukaemia	10.63	9.51	18	151752	15056	50438298
Blood cholesterol increased	10.61	9.51	110	151660	55105	50398249
Mitochondrial myopathy	10.61	9.51	5	151765	72	50453282
Ejection fraction decreased	10.59	9.51	25	151745	18495	50434859
Creatinine renal clearance decreased	10.57	9.51	12	151758	11869	50441485
Exposure via breast milk	10.53	9.51	18	151752	1590	50451764
Electrocardiogram P wave abnormal	10.49	9.51	7	151763	203	50453151
Flat affect	10.44	9.51	16	151754	1289	50452065
Compulsions	10.43	9.51	7	151763	205	50453149
Upper-airway cough syndrome	10.41	9.51	52	151718	8498	50444856
Sluggishness	10.39	9.51	33	151737	4380	50448974
Hypernatraemia	10.37	9.51	42	151728	6279	50447075
Live birth	10.33	9.51	21	151749	16387	50436967
Macular degeneration	10.32	9.51	17	151753	14371	50438983
Incoherent	10.29	9.51	32	151738	4198	50449156
Feeling hot	10.27	9.51	170	151600	39032	50414322
Logorrhoea	10.26	9.51	22	151748	2302	50451052
Pancreatic carcinoma recurrent	10.25	9.51	5	151765	78	50453276
Essential tremor	10.24	9.51	13	151757	878	50452476
Apallic syndrome	10.22	9.51	11	151759	622	50452732
Haematoma	10.21	9.51	138	151632	30372	50422982
Biliary colic	10.21	9.51	27	151743	3232	50450122
Neonatal asphyxia	10.19	9.51	7	151763	213	50453141
Therapeutic response unexpected	10.11	9.51	82	151688	15833	50437521
Immune-mediated myositis	10.09	9.51	14	151756	1031	50452323
Disturbance in sexual arousal	10.08	9.51	5	151765	81	50453273
Neoplasm progression	10.07	9.51	49	151721	29108	50424246
Congenital tracheomalacia	10.05	9.51	4	151766	37	50453317
Diplopia	10.03	9.51	95	151675	19165	50434189
Oesophageal atresia	10.03	9.51	10	151760	517	50452837
Housebound	10.02	9.51	7	151763	219	50453135
Tubulointerstitial nephritis	9.98	9.51	19	151751	15192	50438162
Multiple allergies	9.97	9.51	51	151719	8412	50444942
Endometrial disorder	9.93	9.51	11	151759	643	50452711
Amenorrhoea	9.91	9.51	51	151719	8433	50444921
Cluster headache	9.90	9.51	10	151760	525	50452829
Tic	9.85	9.51	15	151755	1202	50452152
Belligerence	9.85	9.51	6	151764	148	50453206
Psychotic disorder due to a general medical condition	9.80	9.51	7	151763	227	50453127
Micturition disorder	9.79	9.51	19	151751	1852	50451502
Catatonia	9.78	9.51	29	151741	3707	50449647
Yawning	9.77	9.51	13	151757	920	50452434
Erythema	9.75	9.51	350	151420	146064	50307290
Sleep talking	9.73	9.51	13	151757	923	50452431
Electrocardiogram U wave present	9.71	9.51	5	151765	88	50453266
Skin necrosis	9.65	9.51	11	151759	10856	50442498
Splenic thrombosis	9.65	9.51	3	151767	12	50453342
Blood osmolarity increased	9.64	9.51	6	151764	154	50453200
Inappropriate affect	9.63	9.51	12	151758	795	50452559
Speech disorder	9.63	9.51	155	151615	35393	50417961
Basilar migraine	9.61	9.51	4	151766	42	50453312
Anorgasmia	9.60	9.51	10	151760	545	50452809
Osteonecrosis	9.53	9.51	35	151735	22482	50430872
Device placement issue	9.53	9.51	12	151758	804	50452550
Polyarthritis	9.51	9.51	6	151764	7921	50445433

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Serotonin syndrome	423.62	10.02	340	68270	17172	29488745
Completed suicide	293.76	10.02	647	67963	89599	29416318
Suicidal ideation	284.54	10.02	376	68234	34340	29471577
Suicide attempt	247.08	10.02	348	68262	33762	29472155
Intentional overdose	227.29	10.02	357	68253	38171	29467746
Agitation	172.56	10.02	373	68237	50931	29454986
Anxiety	151.67	10.02	489	68121	84876	29421041
Aggression	132.99	10.02	270	68340	35271	29470646
Somnolence	128.71	10.02	494	68116	93461	29412456
Foetal exposure during pregnancy	124.01	10.02	255	68355	33612	29472305
Depression	115.21	10.02	446	68164	84701	29421216
Tremor	114.42	10.02	403	68207	73135	29432782
Sopor	106.25	10.02	129	68481	10805	29495112
Intentional self-injury	100.51	10.02	134	68476	12327	29493590
Overdose	90.51	10.02	396	68214	79423	29426494
Electrocardiogram QT prolonged	90.20	10.02	234	68376	35903	29470014
Paranoia	88.69	10.02	112	68498	9765	29496152
Poisoning deliberate	87.89	10.02	86	68524	5645	29500272
Mania	87.10	10.02	104	68506	8559	29497358
Sexual dysfunction	79.53	10.02	82	68528	5732	29500185
Withdrawal syndrome	79.29	10.02	112	68498	10880	29495037
Drug interaction	75.62	10.02	744	67866	196641	29309276
Febrile neutropenia	69.80	10.02	95	68515	112145	29393772
Intrusive thoughts	69.19	10.02	25	68585	230	29505687
Restlessness	66.52	10.02	154	68456	21991	29483926
Maternal drugs affecting foetus	66.49	10.02	62	68548	3831	29502086
Drug withdrawal syndrome	65.31	10.02	135	68475	17849	29488068
Muscle rigidity	65.10	10.02	94	68516	9317	29496600
Insomnia	63.34	10.02	387	68223	88374	29417543
Disturbance in attention	63.27	10.02	148	68462	21276	29484641
Fall	62.62	10.02	657	67953	176521	29329396
Coma	61.12	10.02	216	68394	39234	29466683
Dyskinesia	60.79	10.02	140	68470	19921	29485996
Confusional state	60.62	10.02	505	68105	127372	29378545
Irritability	57.90	10.02	146	68464	22006	29483911
Activation syndrome	56.41	10.02	17	68593	82	29505835
Major depression	55.93	10.02	56	68554	3779	29502138
Erectile dysfunction	54.92	10.02	126	68484	17883	29488034
Loss of libido	54.24	10.02	44	68566	2252	29503665
Apathy	53.86	10.02	69	68541	6102	29499815
Anger	53.50	10.02	93	68517	10797	29495120
Interstitial lung disease	53.37	10.02	34	68576	57684	29448233
Panic attack	53.03	10.02	80	68530	8246	29497671
Hyperhidrosis	52.91	10.02	292	68318	64248	29441669
Thrombocytopenia	52.74	10.02	150	68460	134673	29371244
Sedation	52.22	10.02	121	68489	17284	29488633
Product substitution issue	51.28	10.02	83	68527	9089	29496828
Libido decreased	50.62	10.02	56	68554	4242	29501675
Pyrexia	50.07	10.02	427	68183	287195	29218722
Neutropenia	49.73	10.02	149	68461	131562	29374355
Septic shock	48.70	10.02	44	68566	62516	29443401
Pneumonia	48.57	10.02	492	68118	319680	29186237
Hypomania	47.87	10.02	40	68570	2135	29503782
Akathisia	47.60	10.02	68	68542	6674	29499243
Renal impairment	47.42	10.02	72	68538	81261	29424656
Anorgasmia	45.47	10.02	24	68586	583	29505334
Gun shot wound	44.40	10.02	29	68581	1056	29504861
Hallucination	44.07	10.02	213	68397	44499	29461418
Parkinsonism	43.64	10.02	68	68542	7210	29498707
Hallucination, visual	43.54	10.02	103	68507	14912	29491005
Mycotic allergy	43.47	10.02	18	68592	246	29505671
Abulia	43.45	10.02	22	68588	489	29505428
Tardive dyskinesia	43.09	10.02	57	68553	5201	29500716
Tachyphrenia	42.44	10.02	29	68581	1140	29504777
Respiratory disorder neonatal	41.70	10.02	31	68579	1394	29504523
Chest injury	41.54	10.02	31	68579	1402	29504515
Sepsis	40.91	10.02	181	68429	142501	29363416
Homicidal ideation	40.82	10.02	39	68571	2485	29503432
Bipolar disorder	40.67	10.02	44	68566	3251	29502666
Mite allergy	40.30	10.02	18	68592	299	29505618
Renal failure	40.01	10.02	141	68469	118458	29387459
Mood swings	39.70	10.02	65	68545	7186	29498731
Neuroleptic malignant syndrome	39.69	10.02	104	68506	16044	29489873
Mydriasis	39.51	10.02	59	68551	6026	29499891
Malignant neoplasm progression	38.76	10.02	70	68540	73789	29432128
Acute kidney injury	38.39	10.02	412	68198	264855	29241062
Spirometry abnormal	37.32	10.02	18	68592	359	29505558
Sleep disorder	37.31	10.02	133	68477	24253	29481664
Alcoholism	37.24	10.02	38	68572	2623	29503294
Hallucination, auditory	37.19	10.02	74	68536	9519	29496398
Drug withdrawal syndrome neonatal	36.19	10.02	42	68568	3353	29502564
Memory impairment	36.13	10.02	174	68436	36296	29469621
Anaemia	35.95	10.02	296	68314	200655	29305262
Multiple organ dysfunction syndrome	35.71	10.02	57	68553	63059	29442858
Foetal malformation	35.47	10.02	13	68597	125	29505792
Abnormal behaviour	35.26	10.02	126	68484	23001	29482916
Infusion related reaction	35.19	10.02	30	68580	43856	29462061
Amnesia	35.07	10.02	124	68486	22519	29483398
Seizure	34.56	10.02	349	68261	92774	29413143
Trisomy 18	34.44	10.02	14	68596	182	29505735
Hyperreflexia	34.18	10.02	37	68573	2735	29503182
Resting tremor	34.18	10.02	20	68590	597	29505320
Social avoidant behaviour	34.08	10.02	38	68572	2904	29503013
Homicide	33.64	10.02	23	68587	905	29505012
Bone marrow failure	33.38	10.02	11	68599	27438	29478479
Impulsive behaviour	33.29	10.02	31	68579	1912	29504005
Conjunctivitis allergic	33.21	10.02	20	68590	630	29505287
Dust allergy	32.89	10.02	18	68592	471	29505446
Small for dates baby	32.79	10.02	41	68569	3538	29502379
Walking aid user	32.17	10.02	27	68583	1450	29504467
Electrocardiogram QT interval	31.83	10.02	9	68601	33	29505884
Anencephaly	31.72	10.02	12	68598	127	29505790
Loss of consciousness	31.66	10.02	286	68324	73770	29432147
Painful respiration	30.95	10.02	24	68586	1150	29504767
Skin dystrophy	30.64	10.02	7	68603	7	29505910
Dyspnoea	30.61	10.02	554	68056	326178	29179739
Delusion	30.43	10.02	75	68535	11141	29494776
Postural orthostatic tachycardia syndrome	30.28	10.02	9	68601	41	29505876
Psychotic disorder	30.27	10.02	110	68500	20244	29485673
Prescribed overdose	30.14	10.02	64	68546	8619	29497298
Electrocardiogram QRS complex prolonged	29.82	10.02	42	68568	4068	29501849
Rheumatoid arthritis	29.63	10.02	19	68591	32133	29473784
Depressed mood	28.93	10.02	94	68516	16354	29489563
Cerebral haematoma	28.39	10.02	42	68568	4254	29501663
Delirium	28.20	10.02	172	68438	39225	29466692
Craniosynostosis	28.16	10.02	14	68596	299	29505618
Blood creatinine increased	28.13	10.02	102	68508	85000	29420917
Clonus	28.03	10.02	31	68579	2347	29503570
Feeling abnormal	27.90	10.02	219	68391	54226	29451691
Drug screen positive	27.81	10.02	39	68571	3762	29502155
Consciousness fluctuating	27.74	10.02	21	68589	971	29504946
Congenital ureteropelvic junction obstruction	27.30	10.02	9	68601	61	29505856
Alcohol use	27.30	10.02	35	68575	3097	29502820
Psychomotor retardation	27.11	10.02	34	68576	2942	29502975
Reversible cerebral vasoconstriction syndrome	27.10	10.02	13	68597	256	29505661
Psychomotor hyperactivity	26.75	10.02	59	68551	8154	29497763
Self esteem decreased	26.65	10.02	16	68594	501	29505416
Lactic acidosis	26.37	10.02	19	68591	30228	29475689
Disorientation	25.83	10.02	136	68474	29379	29476538
Myoclonus	25.18	10.02	78	68532	13231	29492686
Depressed level of consciousness	25.01	10.02	159	68451	36783	29469134
Depressive symptom	24.91	10.02	25	68585	1692	29504225
Extrapyramidal disorder	24.84	10.02	68	68542	10763	29495154
Bradypnoea	24.72	10.02	29	68581	2342	29503575
Bruxism	24.68	10.02	24	68586	1563	29504354
Hyperthermia	24.48	10.02	62	68548	9368	29496549
Catatonia	24.39	10.02	40	68570	4428	29501489
Apraxia	24.25	10.02	21	68589	1177	29504740
Platelet count decreased	24.18	10.02	143	68467	104529	29401388
Libido increased	24.09	10.02	17	68593	704	29505213
Emotional disorder	24.07	10.02	42	68568	4889	29501028
Respiratory failure	23.89	10.02	130	68480	97001	29408916
Anhedonia	23.77	10.02	52	68558	7148	29498769
Cogwheel rigidity	23.58	10.02	21	68589	1222	29504695
Gynaecomastia	23.42	10.02	56	68554	8161	29497756
Cardiac failure	23.05	10.02	100	68510	79187	29426730
Torsade de pointes	23.01	10.02	49	68561	6612	29499305
Gambling disorder	22.97	10.02	23	68587	1552	29504365
Derealisation	22.54	10.02	15	68595	564	29505353
Agitation neonatal	22.37	10.02	19	68591	1037	29504880
Hypersomnia	22.20	10.02	65	68545	10689	29495228
Legal problem	22.18	10.02	10	68600	170	29505747
Feeling guilty	22.14	10.02	12	68598	308	29505609
Reduced facial expression	22.11	10.02	16	68594	690	29505227
Gastrointestinal hypermotility	21.93	10.02	9	68601	120	29505797
Orgasm abnormal	21.67	10.02	9	68601	124	29505793
Priapism	21.61	10.02	38	68572	4450	29501467
Neonatal respiratory distress	21.58	10.02	14	68596	504	29505413
Neonatal pneumonia	21.54	10.02	9	68601	126	29505791
Total lung capacity abnormal	21.54	10.02	9	68601	126	29505791
Pregnancy	21.50	10.02	11	68599	250	29505667
Electrocardiogram QT interval abnormal	21.46	10.02	8	68602	81	29505836
Negative thoughts	21.46	10.02	15	68595	612	29505305
Cardiac failure congestive	21.41	10.02	98	68512	76483	29429434
Off label use	21.14	10.02	534	68076	300266	29205651
Contraindicated product administered	21.05	10.02	8	68602	18258	29487659
Disseminated intravascular coagulation	21.03	10.02	10	68600	19970	29485947
Cytomegalovirus infection	21.01	10.02	14	68596	23201	29482716
Disinhibition	20.96	10.02	28	68582	2579	29503338
Tension	20.95	10.02	24	68586	1889	29504028
Burnout syndrome	20.74	10.02	9	68601	139	29505778
Physical deconditioning	20.67	10.02	16	68594	765	29505152
Abnormal dreams	20.63	10.02	48	68562	6872	29499045
Inhibitory drug interaction	20.59	10.02	21	68589	1449	29504468
Crying	20.41	10.02	41	68569	5310	29500607
Congenital hearing disorder	20.40	10.02	8	68602	94	29505823
Persecutory delusion	20.37	10.02	25	68585	2116	29503801
Parkinsonian gait	20.36	10.02	13	68597	455	29505462
Poor quality sleep	20.30	10.02	49	68561	7184	29498733
Urinary retention	20.19	10.02	135	68475	31763	29474154
Muscle necrosis	20.17	10.02	16	68594	793	29505124
Condition aggravated	19.99	10.02	462	68148	145833	29360084
Judgement impaired	19.88	10.02	14	68596	578	29505339
Cognitive disorder	19.69	10.02	107	68503	23392	29482525
Ejaculation disorder	19.66	10.02	17	68593	951	29504966
Hypoglycaemia neonatal	19.51	10.02	22	68588	1702	29504215
Trisomy 21	19.41	10.02	13	68597	494	29505423
Poisoning	19.31	10.02	59	68551	9934	29495983
Septum pellucidum agenesis	19.22	10.02	7	68603	66	29505851
Atrial septal defect	19.06	10.02	46	68564	6743	29499174
Infantile apnoea	18.91	10.02	16	68594	869	29505048
Retrograde amnesia	18.89	10.02	8	68602	116	29505801
Bronchopulmonary aspergillosis	18.87	10.02	3	68607	12341	29493576
Infection	18.72	10.02	103	68507	76648	29429269
Brain stem haematoma	18.65	10.02	8	68602	120	29505797
Mental disorder	18.56	10.02	69	68541	12836	29493081
Rash	18.30	10.02	320	68290	189499	29316418
Dysgraphia	18.12	10.02	23	68587	2015	29503902
Reactive psychosis	18.04	10.02	4	68606	3	29505914
Physical assault	18.00	10.02	17	68593	1067	29504850
Pancytopenia	17.96	10.02	116	68494	83052	29422865
Stomatitis	17.87	10.02	37	68573	37076	29468841
Pruritus	17.85	10.02	179	68431	116670	29389247
Toxic epidermal necrolysis	17.74	10.02	10	68600	18143	29487774
Bradykinesia	17.67	10.02	30	68580	3417	29502500
Congenital pulmonary hypertension	17.56	10.02	6	68604	46	29505871
Neonatal seizure	17.55	10.02	12	68598	472	29505445
Electrocardiogram QT shortened	17.48	10.02	8	68602	141	29505776
Persistent depressive disorder	17.47	10.02	10	68600	286	29505631
Death	17.44	10.02	634	67976	341450	29164467
Obsessive-compulsive disorder	17.38	10.02	35	68575	4541	29501376
Pain in extremity	17.36	10.02	168	68442	110265	29395652
Neutrophil count decreased	17.35	10.02	48	68562	43519	29462398
Ascites	17.22	10.02	37	68573	36582	29469335
Gastrointestinal haemorrhage	17.14	10.02	111	68499	79422	29426495
Inappropriate antidiuretic hormone secretion	17.04	10.02	60	68550	10872	29495045
Pelvic kidney	17.01	10.02	7	68603	94	29505823
Exposure during pregnancy	16.99	10.02	51	68559	8503	29497414
Oedema peripheral	16.94	10.02	156	68454	103401	29402516
Drug resistance	16.93	10.02	15	68595	21525	29484392
Mental impairment	16.76	10.02	53	68557	9088	29496829
Drug eruption	16.69	10.02	9	68601	16732	29489185
Hypertonia	16.63	10.02	31	68579	3798	29502119
Erythema	16.56	10.02	105	68505	75501	29430416
Urticaria	16.46	10.02	68	68542	54592	29451325
Nightmare	16.38	10.02	61	68549	11356	29494561
Feeling of despair	16.36	10.02	15	68595	907	29505010
Orthostatic hypotension	16.32	10.02	99	68511	22530	29483387
Postictal psychosis	16.25	10.02	8	68602	167	29505750
Toxic encephalopathy	16.01	10.02	34	68576	4578	29501339
Renal dysplasia	15.83	10.02	8	68602	177	29505740
Bradyphrenia	15.73	10.02	32	68578	4182	29501735
Feelings of worthlessness	15.71	10.02	9	68601	258	29505659
Personality disorder	15.65	10.02	16	68594	1107	29504810
Congenital hydronephrosis	15.62	10.02	13	68597	690	29505227
Depersonalisation/derealisation disorder	15.59	10.02	12	68598	569	29505348
Neutropenic sepsis	15.54	10.02	4	68606	11723	29494194
Cough	15.50	10.02	204	68406	126523	29379394
Stress	15.48	10.02	94	68516	21396	29484521
Medication error	15.42	10.02	93	68517	21118	29484799
Helplessness	15.42	10.02	6	68604	69	29505848
Neuropathy peripheral	15.37	10.02	99	68511	70928	29434989
Aspergillus infection	15.24	10.02	3	68607	10578	29495339
Leukopenia	15.21	10.02	71	68539	55132	29450785
Sleep-related eating disorder	15.13	10.02	9	68601	277	29505640
Neonatal hyponatraemia	15.12	10.02	6	68604	73	29505844
Alcohol abuse	15.11	10.02	32	68578	4301	29501616
Haemophagocytic lymphohistiocytosis	15.09	10.02	3	68607	10501	29495416
Head discomfort	15.03	10.02	27	68583	3215	29502702
Hyperglycaemia	15.02	10.02	36	68574	34251	29471666
Family stress	14.92	10.02	7	68603	131	29505786
Atrial fibrillation	14.85	10.02	165	68445	105481	29400436
Weight increased	14.77	10.02	255	68355	76412	29429505
Ejaculation failure	14.63	10.02	13	68597	754	29505163
Palmar-plantar erythrodysaesthesia syndrome	14.61	10.02	8	68602	14751	29491166
Dementia with Lewy bodies	14.59	10.02	12	68598	626	29505291
Hepatotoxicity	14.58	10.02	12	68598	17855	29488062
Inflammation	14.34	10.02	19	68591	22709	29483208
Muscle twitching	14.23	10.02	46	68564	7980	29497937
Sperm concentration decreased	14.14	10.02	7	68603	148	29505769
Somatic symptom disorder	14.06	10.02	11	68599	534	29505383
Pneumocystis jirovecii pneumonia	14.03	10.02	11	68599	16768	29489149
Hypersensitivity	14.02	10.02	69	68541	52834	29453083
Renal haemorrhage	13.96	10.02	16	68594	1260	29504657
Swelling	13.95	10.02	39	68571	35244	29470673
White blood cell count decreased	13.88	10.02	125	68485	83237	29422680
Tearfulness	13.82	10.02	18	68592	1618	29504299
Personality change	13.64	10.02	32	68578	4606	29501311
Stress at work	13.61	10.02	7	68603	161	29505756
Illness anxiety disorder	13.49	10.02	7	68603	164	29505753
Pneumonitis	13.46	10.02	28	68582	28016	29477901
Human herpesvirus 6 infection	13.46	10.02	19	68591	1844	29504073
Rabbit syndrome	13.32	10.02	4	68606	19	29505898
Graft versus host disease	13.32	10.02	3	68607	9625	29496292
Dementia	13.30	10.02	58	68552	11600	29494317
Panic disorder	13.15	10.02	15	68595	1175	29504742
Delusional disorder, erotomanic type	13.13	10.02	3	68607	3	29505914
Rapid eye movements sleep abnormal	13.12	10.02	7	68603	174	29505743
Tumour lysis syndrome	13.07	10.02	8	68602	13876	29492041
Device dislocation	13.06	10.02	31	68579	4496	29501421
Joint swelling	12.99	10.02	65	68545	49565	29456352
Nasopharyngitis	12.99	10.02	83	68527	59582	29446335
Loss of employment	12.94	10.02	10	68600	477	29505440
Ureteric haemorrhage	12.90	10.02	6	68604	110	29505807
Epilepsy	12.88	10.02	80	68530	18352	29487565
Yawning	12.88	10.02	10	68600	480	29505437
Feeling jittery	12.87	10.02	27	68583	3606	29502311
Social fear	12.67	10.02	3	68607	4	29505913
Arthralgia	12.61	10.02	238	68372	139379	29366538
Myocardial infarction	12.61	10.02	180	68430	110116	29395801
Somnambulism	12.59	10.02	23	68587	2775	29503142
Dizziness	12.58	10.02	549	68061	189135	29316782
Hyperammonaemic encephalopathy	12.50	10.02	19	68591	1971	29503946
Premature ejaculation	12.42	10.02	6	68604	120	29505797
Treatment failure	12.38	10.02	44	68566	36895	29469022
Symptom recurrence	12.26	10.02	8	68602	291	29505626
Thinking abnormal	12.13	10.02	33	68577	5203	29500714
Electrocardiogram abnormal	12.12	10.02	41	68569	7281	29498636
Frustration tolerance decreased	12.07	10.02	20	68590	2232	29503685
Selective eating disorder	12.07	10.02	17	68593	1646	29504271
Paresis	12.07	10.02	18	68592	1836	29504081
Congenital megaureter	12.03	10.02	6	68604	129	29505788
Carbon dioxide increased	12.01	10.02	13	68597	961	29504956
Haemoglobin decreased	11.99	10.02	178	68432	108197	29397720
Delusion of grandeur	11.85	10.02	9	68601	418	29505499
Logorrhoea	11.84	10.02	20	68590	2268	29503649
Acute myocardial infarction	11.81	10.02	65	68545	48373	29457544
Grandiosity	11.72	10.02	8	68602	314	29505603
Mucosal inflammation	11.71	10.02	36	68574	31559	29474358
Cleft lip and palate	11.69	10.02	8	68602	315	29505602
Exposure via breast milk	11.69	10.02	17	68593	1695	29504222
Hepatic failure	11.61	10.02	36	68574	31476	29474441
Sprue-like enteropathy	11.61	10.02	9	68601	431	29505486
Pleural effusion	11.46	10.02	109	68501	71799	29434118
Prescription form tampering	11.40	10.02	9	68601	443	29505474
Mood altered	11.36	10.02	43	68567	8068	29497849
Obsessive-compulsive personality disorder	11.32	10.02	6	68604	147	29505770
Back pain	11.31	10.02	168	68442	102116	29403801
Anaphylactic reaction	11.26	10.02	30	68580	27543	29478374
Chronic kidney disease	11.15	10.02	45	68565	36371	29469546
Suture rupture	11.09	10.02	8	68602	343	29505574
Attention deficit hyperactivity disorder	10.97	10.02	19	68591	2198	29503719
Post-traumatic stress disorder	10.92	10.02	16	68594	1606	29504311
Theft	10.86	10.02	7	68603	249	29505668
Obsessive thoughts	10.80	10.02	10	68600	612	29505305
Multiple drug therapy	10.77	10.02	8	68602	359	29505558
Screaming	10.77	10.02	14	68596	1256	29504661
Urogenital haemorrhage	10.76	10.02	9	68601	481	29505436
Imprisonment	10.76	10.02	9	68601	481	29505436
Behaviour disorder	10.69	10.02	25	68585	3591	29502326
Onycholysis	10.66	10.02	9	68601	487	29505430
Neonatal tachypnoea	10.63	10.02	6	68604	167	29505750
Impaired work ability	10.62	10.02	33	68577	5607	29500310
Diffuse alopecia	10.61	10.02	3	68607	11	29505906
Microvascular coronary artery disease	10.60	10.02	4	68606	42	29505875
Affect lability	10.59	10.02	24	68586	3378	29502539
Urinary incontinence	10.58	10.02	70	68540	16411	29489506
Skin exfoliation	10.54	10.02	23	68587	22622	29483295
Congenital diaphragmatic hernia	10.52	10.02	7	68603	263	29505654
Flat affect	10.52	10.02	11	68599	781	29505136
Hypocalcaemia	10.46	10.02	20	68590	20645	29485272
Dissociation	10.45	10.02	13	68597	1116	29504801
Tinnitus	10.44	10.02	67	68543	15547	29490370
Hyponatriuria	10.41	10.02	3	68607	12	29505905
Nephropathy toxic	10.40	10.02	6	68604	10750	29495167
Coronary artery disease	10.39	10.02	60	68550	44130	29461787
Feminisation acquired	10.36	10.02	4	68606	45	29505872
Hypospadias	10.27	10.02	22	68588	2980	29502937
Posterior reversible encephalopathy syndrome	10.23	10.02	4	68606	8972	29496945
Male orgasmic disorder	10.22	10.02	5	68605	103	29505814
Cerebrospinal fluid circulation disorder	10.21	10.02	3	68607	13	29505904
Soft tissue disorder	10.15	10.02	10	68600	662	29505255
Fluid retention	10.11	10.02	25	68585	23535	29482382
Compulsions	10.11	10.02	6	68604	184	29505733
Cryptorchism	10.08	10.02	17	68593	1925	29503992
Hallucination, olfactory	10.08	10.02	6	68604	185	29505732
Renal tubular necrosis	10.06	10.02	11	68599	14304	29491613
Autonomic nervous system imbalance	10.03	10.02	19	68591	2357	29503560

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Serotonin syndrome	613.75	9.67	636	172305	38646	64287145
Suicide attempt	580.67	9.67	828	172113	70179	64255612
Suicidal ideation	576.91	9.67	798	172143	65744	64260047
Intentional overdose	526.32	9.67	899	172042	89045	64236746
Completed suicide	514.32	9.67	1543	171398	222871	64102920
Electrocardiogram QT prolonged	415.45	9.67	756	172185	78692	64247099
Sopor	404.63	9.67	447	172494	29214	64296577
Anxiety	324.57	9.67	1236	171705	201413	64124378
Somnolence	293.73	9.67	1202	171739	202443	64123348
Overdose	271.00	9.67	992	171949	158574	64167217
Drug interaction	232.71	9.67	1714	171227	360369	63965422
Depression	226.67	9.67	1033	171908	182258	64143533
Agitation	225.44	9.67	632	172309	87735	64238056
Tremor	216.00	9.67	878	172063	147352	64178439
Intentional self-injury	192.15	9.67	307	172634	28737	64297054
Coma	183.09	9.67	584	172357	87031	64238760
Synovitis	174.85	9.67	28	172913	99062	64226729
Poisoning deliberate	153.53	9.67	185	172756	13273	64312518
Pemphigus	147.85	9.67	3	172938	60698	64265093
Product substitution issue	146.91	9.67	209	172732	17652	64308139
Contraindicated product administered	146.37	9.67	53	172888	107776	64218015
Withdrawal syndrome	144.12	9.67	240	172701	23252	64302539
Mania	142.03	9.67	196	172745	16090	64309701
Drug intolerance	133.93	9.67	185	172756	187807	64137984
Fall	132.90	9.67	1703	171238	415123	63910668
Joint swelling	132.45	9.67	234	172707	215148	64110643
Hand deformity	130.15	9.67	10	172931	62761	64263030
Febrile neutropenia	128.41	9.67	190	172751	187467	64138324
Akathisia	124.45	9.67	154	172787	11356	64314435
Aggression	123.13	9.67	336	172605	45896	64279895
Arthropathy	123.03	9.67	87	172854	120880	64204911
Treatment failure	122.83	9.67	81	172860	116735	64209056
Inappropriate antidiuretic hormone secretion	122.66	9.67	217	172724	22072	64303719
Infusion related reaction	119.00	9.67	160	172781	164307	64161484
Paranoia	118.11	9.67	180	172761	16172	64309619
Hyponatraemia	116.89	9.67	739	172202	147600	64178191
Irritability	111.07	9.67	280	172661	36466	64289325
Panic attack	108.92	9.67	199	172742	20754	64305037
Muscle rigidity	107.84	9.67	179	172762	17294	64308497
Seizure	104.58	9.67	786	172155	166106	64159685
Torsade de pointes	103.33	9.67	175	172766	17188	64308603
Systemic lupus erythematosus	102.22	9.67	40	172901	77572	64248219
Mydriasis	100.10	9.67	161	172780	15151	64310640
Tardive dyskinesia	97.95	9.67	122	172819	9056	64316735
Acute kidney injury	94.19	9.67	762	172179	448478	63877313
Confusional state	93.48	9.67	1091	171850	260053	64065738
Disturbance in attention	90.55	9.67	279	172662	40795	64284996
Swelling	88.91	9.67	185	172756	160033	64165758
Insomnia	87.78	9.67	863	172078	196973	64128818
Sepsis	87.46	9.67	320	172621	230021	64095770
Mental disorder	86.80	9.67	208	172733	26237	64299554
Hyperhidrosis	86.68	9.67	603	172338	124317	64201474
Neutropenia	86.39	9.67	340	172601	239284	64086507
Dyskinesia	86.33	9.67	267	172674	39121	64286670
Apathy	83.05	9.67	125	172816	11107	64314684
Restlessness	82.88	9.67	265	172676	39520	64286271
Loss of consciousness	81.53	9.67	678	172263	147687	64178104
Duodenal ulcer perforation	79.57	9.67	3	172938	34622	64291169
Crying	79.28	9.67	170	172771	19920	64305871
Multiple organ dysfunction syndrome	79.23	9.67	93	172848	101320	64224471
Drug withdrawal syndrome	78.95	9.67	223	172718	31068	64294723
Helicobacter infection	77.08	9.67	7	172934	38355	64287436
Glossodynia	76.32	9.67	39	172902	64657	64261134
Neuroleptic malignant syndrome	76.09	9.67	191	172750	24805	64300986
Electrocardiogram QRS complex prolonged	75.77	9.67	108	172833	9136	64316655
Drug ineffective	75.39	9.67	1699	171242	838548	63487243
Renal impairment	73.14	9.67	158	172783	134859	64190932
Hyperreflexia	73.07	9.67	93	172848	7055	64318736
Pyrexia	72.61	9.67	1058	171883	557586	63768205
Rheumatoid arthritis	71.45	9.67	215	172726	164079	64161712
Anger	70.10	9.67	140	172801	15601	64310190
Sexual dysfunction	69.03	9.67	86	172855	6385	64319406
Peripheral swelling	69.02	9.67	307	172634	208846	64116945
Sympathomimetic effect	68.65	9.67	19	172922	52	64325739
Pericarditis	67.54	9.67	42	172899	62474	64263317
Infection	67.45	9.67	261	172680	184619	64141172
Arthralgia	67.12	9.67	811	172130	441449	63884342
Rash	66.54	9.67	849	172092	457700	63868091
Hallucination	66.48	9.67	377	172564	72411	64253380
Lower respiratory tract infection	66.44	9.67	94	172847	94520	64231271
Wound	65.44	9.67	65	172876	76412	64249379
Stomatitis	62.97	9.67	124	172817	109481	64216310
Long QT syndrome	62.50	9.67	73	172868	5066	64320725
Clonus	62.12	9.67	79	172862	5988	64319803
Psychotic disorder	62.00	9.67	219	172722	34359	64291432
Depressed mood	61.29	9.67	245	172696	40767	64285024
Interstitial lung disease	61.09	9.67	105	172836	97627	64228164
Activation syndrome	60.67	9.67	24	172917	247	64325544
Off label use	60.54	9.67	1266	171675	631540	63694251
Depressed level of consciousness	59.98	9.67	399	172542	81037	64244754
Bruxism	58.95	9.67	60	172881	3564	64322227
Septic shock	58.26	9.67	122	172819	105315	64220476
Gun shot wound	58.12	9.67	36	172905	1028	64324763
Reversible cerebral vasoconstriction syndrome	57.96	9.67	49	172892	2293	64323498
Intrusive thoughts	56.86	9.67	25	172916	342	64325449
Multiple sclerosis relapse	56.16	9.67	239	172702	40896	64284895
Derealisation	56.03	9.67	40	172901	1455	64324336
Hypersensitivity	55.79	9.67	304	172637	196148	64129643
Pancytopenia	55.74	9.67	197	172744	143112	64182679
Pneumonia	55.72	9.67	1112	171829	558464	63767327
Hallucination, auditory	55.34	9.67	133	172808	16806	64308985
Drug hypersensitivity	55.11	9.67	392	172549	237423	64088368
Extrapyramidal disorder	54.97	9.67	145	172796	19407	64306384
Cytomegalovirus infection	54.48	9.67	16	172925	37183	64288608
Abnormal behaviour	54.43	9.67	206	172735	33416	64292375
C-reactive protein abnormal	54.03	9.67	7	172934	29040	64296751
Libido decreased	53.32	9.67	65	172876	4719	64321072
Psychomotor hyperactivity	53.29	9.67	119	172822	14332	64311459
Thrombocytopenia	52.78	9.67	367	172574	223434	64102357
Hallucination, visual	52.26	9.67	179	172762	27655	64298136
Folliculitis	51.93	9.67	9	172932	30068	64295723
Anhedonia	51.82	9.67	114	172827	13592	64312199
Alopecia	51.80	9.67	248	172693	165442	64160349
Myelosuppression	51.73	9.67	3	172938	23827	64301964
Alcoholism	50.96	9.67	54	172887	3363	64322428
Inflammation	50.87	9.67	60	172881	65240	64260551
Amnesia	50.85	9.67	260	172681	48009	64277782
Cardiac failure	50.79	9.67	183	172758	132190	64193601
Platelet count decreased	50.71	9.67	254	172687	167457	64158334
Hypertonia	50.52	9.67	73	172868	6252	64319539
Muscle injury	50.08	9.67	6	172935	26431	64299360
Delusion	50.04	9.67	133	172808	17881	64307910
Homicidal ideation	49.51	9.67	52	172889	3205	64322586
Memory impairment	49.43	9.67	396	172545	85286	64240505
Bone marrow failure	49.38	9.67	34	172907	47918	64277873
Cholecystitis chronic	49.27	9.67	89	172852	9198	64316593
Impaired healing	48.81	9.67	54	172887	60419	64265372
Galactorrhoea	48.24	9.67	51	172890	3168	64322623
C-reactive protein increased	48.19	9.67	115	172826	94794	64230997
Cerebral haematoma	47.58	9.67	76	172865	7109	64318682
Libido increased	47.51	9.67	39	172902	1751	64324040
Mucosal inflammation	47.17	9.67	59	172882	62525	64263266
Loss of libido	46.96	9.67	44	172897	2360	64323431
Bipolar disorder	45.44	9.67	72	172869	6689	64319102
Psychomotor retardation	45.00	9.67	62	172879	5081	64320710
Dyspnoea	44.26	9.67	1531	171410	717143	63608648
Toxicity to various agents	44.03	9.67	1281	171660	362232	63963559
Parkinsonism	43.92	9.67	110	172831	14263	64311528
Abnormal dreams	43.61	9.67	90	172851	10266	64315525
Feeling abnormal	43.29	9.67	548	172393	133054	64192737
Major depression	42.87	9.67	76	172865	7740	64318051
Muscle twitching	42.75	9.67	130	172811	18868	64306923
Emotional distress	42.15	9.67	200	172741	35838	64289953
Anaemia	42.12	9.67	738	172203	377942	63947849
Blood creatinine increased	41.98	9.67	204	172737	135578	64190213
Tachyphrenia	41.87	9.67	37	172904	1839	64323952
Death	41.42	9.67	982	171959	481723	63844068
Hepatic enzyme increased	40.89	9.67	194	172747	129749	64196042
Hypomania	40.49	9.67	62	172879	5592	64320199
Suicidal behaviour	40.20	9.67	44	172897	2843	64322948
Dizziness	39.99	9.67	1469	171472	428694	63897097
Pregnancy	39.89	9.67	135	172806	20730	64305061
Drug screen positive	39.88	9.67	62	172879	5667	64320124
Adjustment disorder with mixed anxiety and depressed mood	39.50	9.67	13	172928	74	64325717
Disseminated intravascular coagulation	38.90	9.67	19	172922	32329	64293462
Tonsillar ulcer	38.71	9.67	20	172921	399	64325392
Pneumocystis jirovecii pneumonia	38.48	9.67	13	172928	27621	64298170
Abulia	38.46	9.67	26	172915	865	64324926
Hyperthermia	38.42	9.67	110	172831	15440	64310351
Sleep disorder	38.36	9.67	283	172658	59426	64266365
Spirometry abnormal	37.99	9.67	22	172919	554	64325237
Screaming	37.80	9.67	47	172894	3482	64322309
Bradypnoea	37.55	9.67	57	172884	5102	64320689
Malignant neoplasm progression	37.00	9.67	166	172775	112705	64213086
Multiple sclerosis	36.60	9.67	123	172818	18818	64306973
Alcohol use	36.59	9.67	53	172888	4549	64321242
Bradyphrenia	36.43	9.67	79	172862	9327	64316464
Impulsive behaviour	36.07	9.67	40	172901	2623	64323168
Neutrophil count decreased	35.75	9.67	98	172843	77098	64248693
Social avoidant behaviour	35.53	9.67	52	172889	4505	64321286
Hypersomnia	35.45	9.67	125	172816	19592	64306199
Blister	35.14	9.67	106	172835	80861	64244930
Nightmare	35.12	9.67	130	172811	20863	64304928
Hepatic function abnormal	35.03	9.67	75	172866	64238	64261553
Reversible airways obstruction	34.92	9.67	27	172914	1111	64324680
Therapeutic product effect decreased	34.11	9.67	176	172765	115175	64210616
Neutropenic sepsis	34.10	9.67	10	172931	23262	64302529
Disorientation	33.83	9.67	261	172680	55567	64270224
Abdominal discomfort	33.77	9.67	319	172622	182003	64143788
Self esteem decreased	33.14	9.67	24	172917	893	64324898
Myocardial infarction	32.95	9.67	285	172656	165536	64160255
Discomfort	32.91	9.67	109	172832	80769	64245022
Sinus bradycardia	32.80	9.67	135	172806	22758	64303033
Optic nerve injury	32.61	9.67	20	172921	561	64325230
Drug abuse	32.46	9.67	517	172424	131857	64193934
Sedation	32.26	9.67	206	172735	41256	64284535
Vital capacity decreased	31.95	9.67	25	172916	1047	64324744
Negative thoughts	31.44	9.67	27	172914	1291	64324500
Myoclonus	31.29	9.67	142	172799	24976	64300815
Emotional disorder	30.97	9.67	89	172852	12518	64313273
Oculogyric crisis	30.78	9.67	36	172905	2502	64323289
Mobility decreased	30.76	9.67	122	172819	85718	64240073
Orgasm abnormal	30.44	9.67	13	172928	165	64325626
Aspergillus infection	30.34	9.67	4	172937	16375	64309416
Anorgasmia	30.18	9.67	23	172918	926	64324865
Pain in extremity	29.86	9.67	603	172338	302482	64023309
Resting tremor	29.80	9.67	27	172914	1387	64324404
Acute myocardial infarction	29.74	9.67	92	172849	69626	64256165
Hostility	29.63	9.67	33	172908	2174	64323617
Osteoporosis	29.34	9.67	42	172899	42038	64283753
Depressive symptom	29.01	9.67	47	172894	4449	64321342
Erectile dysfunction	28.97	9.67	87	172854	12540	64313251
Generalised tonic-clonic seizure	28.56	9.67	194	172747	39663	64286128
Renal failure	28.31	9.67	331	172610	181357	64144434
Arthritis	28.23	9.67	122	172819	83692	64242099
Nasopharyngitis	27.99	9.67	364	172577	195709	64130082
Obsessive-compulsive disorder	27.92	9.67	48	172893	4770	64321021
Red blood cell sedimentation rate abnormal	27.88	9.67	5	172936	16301	64309490
Lower respiratory tract infection viral	27.88	9.67	22	172919	933	64324858
Drug resistance	27.61	9.67	32	172909	35070	64290721
Legal problem	27.44	9.67	12	172929	162	64325629
Cogwheel rigidity	27.41	9.67	36	172905	2817	64322974
Poor quality sleep	27.34	9.67	112	172829	18839	64306952
Head injury	27.32	9.67	166	172775	32676	64293115
Miosis	27.29	9.67	88	172853	13178	64312613
Pulmonary embolism	27.16	9.67	547	172394	145809	64179982
Feeling jittery	27.02	9.67	76	172865	10559	64315232
Skin ulcer	26.78	9.67	48	172893	43926	64281865
Pruritus	26.61	9.67	636	172305	311764	64014027
Behaviour disorder	26.58	9.67	45	172896	4417	64321374
Bronchopulmonary aspergillosis	26.54	9.67	9	172932	19076	64306715
Gestational diabetes	26.44	9.67	51	172890	5539	64320252
Alcohol abuse	26.38	9.67	47	172894	4805	64320986
Affective disorder	26.33	9.67	56	172885	6524	64319267
Feeling guilty	26.29	9.67	20	172921	803	64324988
Morose	26.22	9.67	8	172933	34	64325757
Persecutory delusion	26.20	9.67	43	172898	4115	64321676
Disease progression	26.18	9.67	248	172693	141432	64184359
Syncope	25.96	9.67	579	172362	157056	64168735
Electrocardiogram QT interval	25.94	9.67	11	172930	137	64325654
Disinhibition	25.85	9.67	31	172910	2212	64323579
Platelet aggregation inhibition	25.73	9.67	11	172930	140	64325651
Stiff person syndrome	25.64	9.67	13	172928	249	64325542
Feeling of despair	25.60	9.67	33	172908	2535	64323256
White blood cell count decreased	25.58	9.67	285	172656	157552	64168239
Restless legs syndrome	25.37	9.67	102	172839	17014	64308777
Thermohypoaesthesia	25.36	9.67	10	172931	102	64325689
Catatonia	25.07	9.67	60	172881	7560	64318231
Sinusitis	25.06	9.67	260	172681	145668	64180123
Haemophagocytic lymphohistiocytosis	25.02	9.67	8	172933	17601	64308190
Mood swings	25.02	9.67	103	172838	17365	64308426
Sepsis neonatal	24.85	9.67	8	172933	42	64325749
Moaning	24.61	9.67	21	172920	995	64324796
Sight disability	24.53	9.67	10	172931	112	64325679
Epilepsy	24.50	9.67	164	172777	33367	64292424
Somnambulism	24.44	9.67	47	172894	5094	64320697
Bradykinesia	24.16	9.67	54	172887	6506	64319285
Mite allergy	24.05	9.67	18	172923	705	64325086
Haemoglobin decreased	24.00	9.67	373	172568	194690	64131101
Initial insomnia	23.92	9.67	50	172891	5754	64320037
Respiratory arrest	23.87	9.67	232	172709	52753	64273038
Bundle branch block left	23.84	9.67	70	172871	9964	64315827
Poisoning	23.84	9.67	119	172822	21760	64304031
Learning disorder	23.73	9.67	16	172925	530	64325261
Pyramidal tract syndrome	23.67	9.67	16	172925	532	64325259
Bradycardia	23.67	9.67	447	172494	117772	64208019
Judgement impaired	23.62	9.67	21	172920	1052	64324739
Dysgraphia	23.38	9.67	37	172904	3434	64322357
Tachycardia	23.26	9.67	545	172396	149034	64176757
Dysphoria	23.21	9.67	42	172899	4346	64321445
Angle closure glaucoma	23.20	9.67	32	172909	2625	64323166
Maternal exposure during pregnancy	23.19	9.67	156	172785	95728	64230063
Weight increased	23.14	9.67	742	172199	212606	64113185
Knee arthroplasty	23.03	9.67	23	172918	26976	64298815
Product use issue	23.01	9.67	278	172663	151437	64174354
Device dislocation	22.95	9.67	115	172826	21063	64304728
Mental status changes	22.93	9.67	258	172683	60904	64264887
Neuropathy peripheral	22.89	9.67	203	172738	117322	64208469
Transplant rejection	22.85	9.67	9	172932	17392	64308399
Cardiac failure congestive	22.69	9.67	232	172709	130348	64195443
Postictal state	22.68	9.67	25	172916	1628	64324163
Nervousness	22.47	9.67	146	172795	29410	64296381
Orthostatic hypotension	22.22	9.67	207	172734	46531	64279260
Cough	21.80	9.67	630	172311	301518	64024273
Ejaculation failure	21.74	9.67	13	172928	348	64325443
Erythema	21.59	9.67	362	172579	186708	64139083
Blood prolactin increased	21.58	9.67	36	172905	3492	64322299
Uterine perforation	21.54	9.67	48	172893	5772	64320019
Atrial fibrillation	21.44	9.67	326	172615	170763	64155028
Self-injurious ideation	21.42	9.67	34	172907	3163	64322628
Bronchial secretion retention	21.41	9.67	30	172911	2497	64323294
Thinking abnormal	21.41	9.67	74	172867	11482	64314309
Rheumatoid nodule	21.37	9.67	4	172937	12647	64313144
Tearfulness	21.33	9.67	42	172899	4631	64321160
Tumour lysis syndrome	21.08	9.67	13	172928	19427	64306364
Middle insomnia	20.92	9.67	79	172862	12798	64312993
Sinus tachycardia	20.92	9.67	153	172788	32035	64293756
Irritable bowel syndrome	20.83	9.67	43	172898	37326	64288465
Band sensation	20.81	9.67	16	172925	653	64325138
Antiphospholipid antibodies	20.74	9.67	9	172932	119	64325672
Tension	20.63	9.67	37	172904	3803	64321988
Sleep-related eating disorder	20.53	9.67	16	172925	666	64325125
Tubulointerstitial nephritis	20.43	9.67	32	172909	30877	64294914
Anaphylactic shock	20.43	9.67	31	172910	30297	64295494
Ascites	20.42	9.67	91	172850	61910	64263881
Cellulitis	20.41	9.67	157	172784	93500	64232291
Lip ulceration	20.40	9.67	26	172915	1975	64323816
Heavy menstrual bleeding	20.38	9.67	75	172866	12002	64313789
Hyperglycaemia	20.38	9.67	89	172852	60879	64264912
Victim of sexual abuse	20.30	9.67	13	172928	394	64325397
Conversion disorder	20.21	9.67	24	172917	1695	64324096
Pain	20.21	9.67	1247	171694	552264	63773527
Foetal exposure during pregnancy	20.16	9.67	40	172901	4436	64321355
Dystonia	20.13	9.67	102	172839	18763	64307028
Mental impairment	20.06	9.67	92	172849	16251	64309540
Slow speech	20.03	9.67	26	172915	2011	64323780
Delirium	19.98	9.67	278	172663	68916	64256875
Headache	19.93	9.67	1663	171278	527804	63797987
Gambling disorder	19.93	9.67	25	172916	1869	64323922
Respiratory failure	19.89	9.67	308	172633	160875	64164916
Post-traumatic neck syndrome	19.84	9.67	25	172916	1877	64323914
Bipolar I disorder	19.64	9.67	24	172917	1747	64324044
Device expulsion	19.63	9.67	110	172831	21026	64304765
Migraine	19.40	9.67	255	172686	62422	64263369
Treatment noncompliance	19.40	9.67	190	172751	43292	64282499
Hypertension	19.35	9.67	538	172403	258723	64067068
Chest injury	19.32	9.67	28	172913	2405	64323386
Reduced facial expression	19.28	9.67	26	172915	2087	64323704
Logorrhoea	19.16	9.67	37	172904	4022	64321769
Family stress	19.01	9.67	15	172926	636	64325155
Bone erosion	18.89	9.67	4	172937	11591	64314200
Carcinoid syndrome	18.82	9.67	9	172932	151	64325640
Hypervigilance	18.80	9.67	13	172928	449	64325342
Fear	18.75	9.67	105	172836	20066	64305725
Immobilisation prolonged	18.70	9.67	8	172933	102	64325689
Euphoric mood	18.65	9.67	49	172892	6542	64319249
Self-medication	18.62	9.67	37	172904	4108	64321683
Acute myeloid leukaemia	18.57	9.67	28	172913	27435	64298356
Conjunctivitis allergic	18.50	9.67	18	172923	1012	64324779
Biliary dyskinesia	18.40	9.67	27	172914	2345	64323446
Graft versus host disease	18.38	9.67	7	172934	13806	64311985
Gynaecomastia	18.34	9.67	46	172895	5970	64319821
Nausea	18.32	9.67	2389	170552	783411	63542380
Painful respiration	18.26	9.67	31	172910	3050	64322741
Breast swelling	18.24	9.67	18	172923	1030	64324761
Red blood cell sedimentation rate increased	18.22	9.67	35	172906	31200	64294591
Tongue biting	18.15	9.67	23	172918	1737	64324054
Retroplacental haematoma	18.03	9.67	8	172933	112	64325679
Dry mouth	17.96	9.67	244	172697	60174	64265617
Illness anxiety disorder	17.77	9.67	10	172931	238	64325553
Drug withdrawal syndrome neonatal	17.62	9.67	10	172931	242	64325549
Personality disorder	17.60	9.67	39	172902	4672	64321119
Head banging	17.60	9.67	13	172928	499	64325292
Hepatotoxicity	17.56	9.67	52	172889	39910	64285881
Intermenstrual bleeding	17.56	9.67	41	172900	5084	64320707
Leukopenia	17.53	9.67	180	172761	101062	64224729
Parkinsonian gait	17.48	9.67	16	172925	833	64324958
Obsessive-compulsive personality disorder	17.42	9.67	8	172933	122	64325669
Injury	17.42	9.67	228	172713	55764	64270027
Hip arthroplasty	17.30	9.67	19	172922	21332	64304459
Nephropathy toxic	17.27	9.67	13	172928	17501	64308290
Torticollis	17.20	9.67	25	172916	2152	64323639
Mycotic allergy	17.11	9.67	17	172924	981	64324810
Palmar-plantar erythrodysaesthesia syndrome	17.07	9.67	32	172909	28787	64297004
Barotrauma	17.01	9.67	9	172932	189	64325602
Colitis microscopic	16.86	9.67	51	172890	7381	64318410
Obsessive thoughts	16.84	9.67	17	172924	1000	64324791
Ill-defined disorder	16.82	9.67	61	172880	43991	64281800
Skin dystrophy	16.71	9.67	6	172935	46	64325745
Deep vein thrombosis	16.58	9.67	384	172557	104798	64220993
Suspected suicide	16.55	9.67	56	172885	8598	64317193
Grandiosity	16.46	9.67	13	172928	552	64325239
Enthesopathy	16.38	9.67	3	172938	9635	64316156
Dust allergy	16.34	9.67	17	172924	1036	64324755
Decreased interest	16.32	9.67	31	172910	3329	64322462
Male orgasmic disorder	16.28	9.67	6	172935	50	64325741
Trunk injury	16.25	9.67	5	172936	22	64325769
Pleural effusion	16.24	9.67	240	172701	126319	64199472
Speech disorder	16.23	9.67	200	172741	48241	64277550
Enterocolitis	16.14	9.67	6	172935	12012	64313779
Neoplasm progression	16.12	9.67	56	172885	40908	64284883
Kidney transplant rejection	16.08	9.67	3	172938	9508	64316283
Colitis	15.98	9.67	92	172849	58582	64267209
Pneumonitis	15.95	9.67	75	172866	50290	64275501
Bundle branch block right	15.86	9.67	62	172879	10207	64315584
Large intestine anastomosis	15.84	9.67	7	172934	97	64325694
Partner stress	15.83	9.67	10	172931	296	64325495
Cerebral thrombosis	15.73	9.67	24	172917	2158	64323633
Hemianopia	15.69	9.67	20	172921	1519	64324272
Retrograde amnesia	15.66	9.67	12	172929	487	64325304
Freezing phenomenon	15.62	9.67	20	172921	1526	64324265
Road traffic accident	15.55	9.67	138	172803	30607	64295184
Epstein-Barr virus infection	15.53	9.67	7	172934	12481	64313310
Ocular hypertension	15.48	9.67	18	172923	1243	64324548
Coma scale abnormal	15.48	9.67	51	172890	7723	64318068
Rectal ulcer	15.47	9.67	22	172919	1857	64323934
Left ventricle outflow tract obstruction	15.44	9.67	10	172931	309	64325482
Neuromyelitis optica spectrum disorder	15.44	9.67	15	172926	842	64324949
Gallbladder disorder	15.40	9.67	88	172853	16942	64308849
Soft tissue injury	15.29	9.67	20	172921	1559	64324232
Schizoaffective disorder	15.21	9.67	20	172921	1567	64324224
Inappropriate affect	15.17	9.67	18	172923	1270	64324521
Drug screen false positive	15.10	9.67	16	172925	996	64324795
Sleep talking	15.06	9.67	16	172925	999	64324792
Anterograde amnesia	15.04	9.67	13	172928	627	64325164
Reactive psychosis	15.01	9.67	4	172937	9	64325782
Angina pectoris	14.95	9.67	66	172875	45015	64280776
Cerebellar syndrome	14.92	9.67	38	172903	4978	64320813
Postural orthostatic tachycardia syndrome	14.90	9.67	12	172929	524	64325267
Neurotoxicity	14.88	9.67	32	172909	27372	64298419
Imprisonment	14.87	9.67	12	172929	526	64325265
Brain stem haematoma	14.72	9.67	7	172934	116	64325675
Compulsions	14.70	9.67	10	172931	336	64325455
Pneumonia fungal	14.59	9.67	3	172938	8874	64316917
Psychomotor skills impaired	14.56	9.67	32	172909	3813	64321978
Spinal cord oedema	14.50	9.67	10	172931	344	64325447
Hypophosphataemia	14.42	9.67	11	172930	14709	64311082
Focal dyscognitive seizures	14.34	9.67	29	172912	3261	64322530
Urinary retention	14.33	9.67	198	172743	49003	64276788
Coronary artery disease	14.27	9.67	99	172842	60334	64265457
Caesarean section	14.24	9.67	64	172877	11210	64314581
Haemoglobin urine	14.20	9.67	7	172934	126	64325665
Foot deformity	14.14	9.67	14	172927	16490	64309301
Diarrhoea	14.10	9.67	1710	171231	720994	63604797
Autonomic nervous system imbalance	14.10	9.67	33	172908	4099	64321692
Hepatitis infectious mononucleosis	14.10	9.67	7	172934	128	64325663
Ovarian vein thrombosis	14.08	9.67	5	172936	37	64325754
Hydrops foetalis	14.06	9.67	6	172935	76	64325715
Osteonecrosis of jaw	14.01	9.67	57	172884	39768	64286023
Gastrointestinal haemorrhage	13.99	9.67	260	172681	132052	64193739
Intraventricular haemorrhage	13.99	9.67	33	172908	4120	64321671
Hyperphagia	13.96	9.67	23	172918	2208	64323583
Myositis	13.91	9.67	14	172927	16363	64309428
Hypokinesia	13.87	9.67	84	172857	16512	64309279
Flight of ideas	13.86	9.67	13	172928	698	64325093
Electrocardiogram QT interval abnormal	13.85	9.67	9	172932	280	64325511
Apnoea	13.80	9.67	60	172881	10362	64315429
Delusion of grandeur	13.72	9.67	12	172929	588	64325203
Product substitution error	13.64	9.67	5	172936	41	64325750
Sputum culture positive	13.58	9.67	27	172914	2999	64322792
Dysarthria	13.43	9.67	229	172712	59177	64266614
Extradural haematoma	13.38	9.67	25	172916	2651	64323140
Musculoskeletal stiffness	13.37	9.67	241	172700	122965	64202826
Device related infection	13.35	9.67	40	172901	30586	64295205
Cardio-respiratory arrest	13.35	9.67	352	172589	98041	64227750
Device placement issue	13.33	9.67	13	172928	733	64325058
Abortion spontaneous	13.31	9.67	114	172827	25029	64300762
Belligerence	13.27	9.67	9	172932	301	64325490
Neoplasm malignant	13.27	9.67	29	172912	24659	64301132
Psychiatric symptom	13.26	9.67	42	172899	6231	64319560
Drug use disorder	13.22	9.67	41	172900	6013	64319778
Ventricular dyskinesia	13.22	9.67	10	172931	398	64325393
Peripheral sensory neuropathy	13.21	9.67	7	172934	11371	64314420
Metabolic acidosis	13.19	9.67	124	172817	70834	64254957
Drug eruption	13.17	9.67	51	172890	36085	64289706
Concussion	13.15	9.67	49	172892	7889	64317902
Respiratory disorder	13.14	9.67	51	172890	36060	64289731
Electrocardiogram abnormal	13.08	9.67	71	172870	13410	64312381
Pulmonary fibrosis	13.04	9.67	39	172902	29839	64295952
Lethargy	13.02	9.67	270	172671	72324	64253467
Cytotoxic oedema	12.96	9.67	9	172932	313	64325478
Compulsive shopping	12.89	9.67	13	172928	764	64325027
Atrial flutter	12.87	9.67	20	172921	19360	64306431
Total lung capacity abnormal	12.85	9.67	7	172934	156	64325635
Hyperventilation	12.85	9.67	44	172897	6796	64318995
Menometrorrhagia	12.80	9.67	12	172929	644	64325147
Cardiogenic shock	12.70	9.67	138	172803	32289	64293502
Muscle necrosis	12.64	9.67	16	172925	1207	64324584
Creatinine renal clearance decreased	12.63	9.67	12	172929	14409	64311382
Hypermetropia	12.61	9.67	10	172931	427	64325364
Bacteraemia	12.58	9.67	34	172907	26877	64298914
Impaired driving ability	12.56	9.67	34	172907	4620	64321171
Osteoarthritis	12.50	9.67	109	172832	63227	64262564
Vertigo	12.46	9.67	225	172716	58786	64267005
Alcohol poisoning	12.41	9.67	32	172909	4223	64321568
Inhibitory drug interaction	12.41	9.67	29	172912	3598	64322193
Pelvic pain	12.36	9.67	60	172881	10850	64314941
Ileus	12.32	9.67	27	172914	22939	64302852
Basal cell carcinoma	12.24	9.67	42	172899	30796	64294995
Arthritis bacterial	12.18	9.67	3	172938	7836	64317955
Bile acid malabsorption	12.17	9.67	7	172934	174	64325617
Superior sagittal sinus thrombosis	12.10	9.67	14	172927	962	64324829
Electroencephalogram abnormal	12.08	9.67	36	172905	5167	64320624
Aphasia	12.07	9.67	165	172776	40741	64285050
Attention-seeking behaviour	12.07	9.67	6	172935	110	64325681
Joint hyperextension	12.05	9.67	8	172933	258	64325533
Fibromyalgia	12.04	9.67	52	172889	35679	64290112
Retching	11.99	9.67	76	172865	15180	64310611
Pulmonary toxicity	11.97	9.67	4	172937	8557	64317234
Hepatitis chronic active	11.96	9.67	7	172934	180	64325611
Complication of device insertion	11.94	9.67	35	172906	4977	64320814
Xerophthalmia	11.86	9.67	10	172931	466	64325325
Retinal ischaemia	11.86	9.67	12	172929	708	64325083
Sialoadenitis	11.83	9.67	18	172923	1615	64324176
Extensor plantar response	11.77	9.67	18	172923	1622	64324169
Priapism	11.73	9.67	30	172911	3940	64321851
Unresponsive to stimuli	11.66	9.67	195	172746	50198	64275593
Rash maculo-papular	11.62	9.67	76	172865	46950	64278841
Sperm concentration decreased	11.60	9.67	5	172936	65	64325726
Nephropathy	11.58	9.67	4	172937	8382	64317409
Mood altered	11.58	9.67	78	172863	15901	64309890
Laryngectomy	11.58	9.67	4	172937	27	64325764
Hyperkalaemia	11.56	9.67	196	172745	100933	64224858
Anti-actin antibody positive	11.49	9.67	3	172938	6	64325785
Wound healing normal	11.49	9.67	3	172938	6	64325785
Tinnitus	11.47	9.67	141	172800	33992	64291799
Ejection fraction decreased	11.46	9.67	39	172902	28668	64297123
Panic reaction	11.46	9.67	30	172911	3997	64321794
Gambling	11.45	9.67	8	172933	281	64325510
Stoma site discharge	11.42	9.67	18	172923	1664	64324127
Hyperdynamic left ventricle	11.40	9.67	8	172933	283	64325508
Psoriasis	11.36	9.67	262	172679	71441	64254350
Female orgasmic disorder	11.33	9.67	4	172937	29	64325762
Ejaculation disorder	11.30	9.67	10	172931	498	64325293
Drug-induced liver injury	11.27	9.67	78	172863	47565	64278226
General physical health deterioration	11.26	9.67	441	172500	203984	64121807
Optic atrophy	11.26	9.67	18	172923	1685	64324106
Endometrial disorder	11.25	9.67	10	172931	501	64325290
Thrombotic microangiopathy	11.24	9.67	17	172924	16638	64309153
Upper-airway cough syndrome	11.24	9.67	50	172891	8720	64317071
Angina unstable	11.22	9.67	15	172926	15452	64310339
Prescribed overdose	11.19	9.67	93	172848	20238	64305553
Paraesthesia	11.17	9.67	454	172487	134068	64191723
Yawning	11.15	9.67	15	172926	1201	64324590
Diffuse large B-cell lymphoma	11.13	9.67	7	172934	10354	64315437
Anaphylactic reaction	11.11	9.67	124	172817	68540	64257251
Hot flush	11.10	9.67	180	172761	46055	64279736
Product use in unapproved indication	11.08	9.67	375	172566	176243	64149548
Mucormycosis	11.04	9.67	3	172938	7338	64318453
Balance disorder	11.02	9.67	299	172642	83627	64242164
Hypogammaglobulinaemia	11.01	9.67	7	172934	10292	64315499
Burnout syndrome	10.99	9.67	8	172933	300	64325491
Nephrotic syndrome	10.94	9.67	6	172935	9561	64316230
Merycism	10.91	9.67	7	172934	213	64325578
Carboxyhaemoglobin increased	10.89	9.67	4	172937	33	64325758
Metastases to lung	10.87	9.67	15	172926	15249	64310542
Intentional product use issue	10.84	9.67	185	172756	95179	64230612
Musculoskeletal pain	10.83	9.67	153	172788	81141	64244650
Pulmonary tuberculosis	10.82	9.67	3	172938	7241	64318550
Cytokine release syndrome	10.76	9.67	25	172916	20804	64304987
Creatinine urine decreased	10.73	9.67	7	172934	219	64325572
Posterior reversible encephalopathy syndrome	10.72	9.67	29	172912	22917	64302874
Nuchal rigidity	10.68	9.67	13	172928	942	64324849
Cholangitis	10.67	9.67	8	172933	10794	64314997
Cataract	10.67	9.67	87	172854	51175	64274616
Cardiac arrest	10.60	9.67	510	172431	153554	64172237
Delusional disorder, erotomanic type	10.58	9.67	4	172937	36	64325755
Cognitive disorder	10.58	9.67	207	172734	54880	64270911
Amenorrhoea	10.53	9.67	40	172901	6499	64319292
Pseudomonas infection	10.46	9.67	20	172921	17863	64307928
Liver disorder	10.45	9.67	92	172849	53259	64272532
Hypercalcaemia	10.41	9.67	46	172895	31370	64294421
Blood urea nitrogen/creatinine ratio decreased	10.40	9.67	5	172936	85	64325706
Blood gases abnormal	10.38	9.67	13	172928	970	64324821
Suture rupture	10.34	9.67	10	172931	558	64325233
Lymphadenopathy	10.29	9.67	78	172863	46608	64279183
Homicide	10.26	9.67	14	172927	1137	64324654
Cytopenia	10.24	9.67	16	172925	15455	64310336
Dissociation	10.22	9.67	24	172917	2987	64322804
Staring	10.21	9.67	21	172920	2389	64323402
Emotional poverty	10.21	9.67	11	172930	698	64325093
Lung consolidation	10.21	9.67	4	172937	7754	64318037
Dermatitis atopic	10.14	9.67	28	172913	3848	64321943
Shoulder deformity	10.13	9.67	4	172937	41	64325750
Flat affect	10.11	9.67	18	172923	1839	64323952
Inflammatory marker increased	10.11	9.67	5	172936	8446	64317345
Foreign body in reproductive tract	10.10	9.67	9	172932	452	64325339
Drug dependence	10.09	9.67	135	172806	33177	64292614
Oedema peripheral	10.05	9.67	461	172480	209856	64115935
Sternal fracture	10.02	9.67	20	172921	2227	64323564
Hypochloraemia	9.99	9.67	19	172922	2042	64323749
Blood alcohol increased	9.97	9.67	14	172927	1168	64324623
Cerebellar haematoma	9.95	9.67	10	172931	585	64325206
Wheezing	9.93	9.67	154	172787	80425	64245366
Lactic acidosis	9.90	9.67	111	172830	61299	64264492
Polyarthritis	9.85	9.67	7	172934	9708	64316083
Erection increased	9.85	9.67	8	172933	354	64325437
Choroidal effusion	9.71	9.67	10	172931	602	64325189
Polydipsia	9.70	9.67	36	172905	5785	64320006

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Human herpesvirus 6 infection	34.35	33.45	15	812	45	83806

Pharmacologic Action:

Source	Code	Description
ATC	N06AB10	NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Selective serotonin reuptake inhibitors
FDA MoA	N0000000109	Serotonin Uptake Inhibitors
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D014179	Neurotransmitter Uptake Inhibitors
MeSH PA	D018490	Serotonin Agents
MeSH PA	D017367	Serotonin Uptake Inhibitors
FDA EPC	N0000175696	Serotonin Reuptake Inhibitor
CHEBI has role	CHEBI:35469	antidepressants
CHEBI has role	CHEBI:76779	post-proline endopeptidase inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Generalized anxiety disorder	indication	21897009	DOID:14320
Major depressive disorder	indication	370143000
Posttraumatic stress disorder	off-label use	47505003	DOID:2055
Bipolar affective disorder, current episode depression	off-label use	191627008	DOID:3312
Obsessive-compulsive disorder	off-label use	191736004	DOID:10933
Menopausal flushing	off-label use	198436008
Panic disorder	off-label use	371631005	DOID:594
Suicidal thoughts	contraindication	6471006
Bipolar disorder	contraindication	13746004	DOID:3312
Neuroleptic malignant syndrome	contraindication	15244003	DOID:14464
Upper gastrointestinal hemorrhage	contraindication	37372002
Syndrome of inappropriate vasopressin secretion	contraindication	55004003	DOID:3401
Heart disease	contraindication	56265001	DOID:114
Acute nephropathy	contraindication	58574008
Blood coagulation disorder	contraindication	64779008	DOID:1247
Epilepsy	contraindication	84757009	DOID:1826
Hyponatremia	contraindication	89627008
Disease of liver	contraindication	235856003	DOID:409
Serotonin syndrome	contraindication	371089000
Myocardial infarction in recovery phase	contraindication	418044006

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.33	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN	INHIBITOR	Ki	8.96	WOMBAT-PK	CHEMBL
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	5.19	PDSP
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	5.60	PDSP
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN		Ki	5.41	PDSP
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN		Ki	5.71	PDSP
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN		Ki	5.91	PDSP
Sodium-dependent serotonin transporter	Transporter		SC6A4_RAT		Ki	9.05	CHEMBL
Sodium-dependent dopamine transporter	Transporter		SC6A3_RAT		Ki	5.09	CHEMBL
Transporter	Transporter		Q63380_RAT		Ki	4.98	CHEMBL

External reference:

ID	Source
4024285	VUID
N0000022289	NUI
D02567	KEGG_DRUG
219861-08-2	SECONDARY_CAS_RN
4021356	VANDF
4024285	VANDF
C1099456	UMLSCUI
CHEBI:36791	CHEBI
68P	PDB_CHEM_ID
CHEMBL1508	ChEMBL_ID
DB01175	DRUGBANK_ID
CHEMBL1200322	ChEMBL_ID
D000089983	MESH_DESCRIPTOR_UI
146570	PUBCHEM_CID
7177	IUPHAR_LIGAND_ID
7953	INN_ID
4O4S742ANY	UNII
321988	RXNORM
158618	MMSL
16927	MMSL
187848	MMSL
d04812	MMSL
009709	NDDF
009710	NDDF
395246009	SNOMEDCT_US
400447003	SNOMEDCT_US
412384000	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Escitalopram Oxalate	HUMAN PRESCRIPTION DRUG LABEL	1	0121-0852	SOLUTION	10 mg	ORAL	ANDA	36 sections
Lexapro	HUMAN PRESCRIPTION DRUG LABEL	1	0456-2005	TABLET, FILM COATED	5 mg	ORAL	NDA	32 sections
Lexapro	HUMAN PRESCRIPTION DRUG LABEL	1	0456-2005	TABLET, FILM COATED	5 mg	ORAL	NDA	32 sections
Lexapro	HUMAN PRESCRIPTION DRUG LABEL	1	0456-2010	TABLET, FILM COATED	10 mg	ORAL	NDA	32 sections
Lexapro	HUMAN PRESCRIPTION DRUG LABEL	1	0456-2010	TABLET, FILM COATED	10 mg	ORAL	NDA	32 sections
Lexapro	HUMAN PRESCRIPTION DRUG LABEL	1	0456-2020	TABLET, FILM COATED	20 mg	ORAL	NDA	32 sections
Lexapro	HUMAN PRESCRIPTION DRUG LABEL	1	0456-2020	TABLET, FILM COATED	20 mg	ORAL	NDA	32 sections
Lexapro	HUMAN PRESCRIPTION DRUG LABEL	1	0456-2101	SOLUTION	5 mg	ORAL	NDA	32 sections
Lexapro	HUMAN PRESCRIPTION DRUG LABEL	1	0456-2101	SOLUTION	5 mg	ORAL	NDA	32 sections
Escitalopram	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7953	TABLET	5 mg	ORAL	ANDA	31 sections
Escitalopram	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7954	TABLET	10 mg	ORAL	ANDA	31 sections
Escitalopram	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7955	TABLET	20 mg	ORAL	ANDA	31 sections
Escitalopram	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8348	TABLET, FILM COATED	5 mg	ORAL	ANDA	31 sections
Escitalopram	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8349	TABLET, FILM COATED	10 mg	ORAL	ANDA	31 sections
Escitalopram	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8350	TABLET, FILM COATED	20 mg	ORAL	ANDA	31 sections
Escitalopram	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8365	TABLET, FILM COATED	10 mg	ORAL	ANDA	31 sections
Escitalopram	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8366	TABLET, FILM COATED	20 mg	ORAL	ANDA	31 sections
escitalopram oxalate	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6426	TABLET	10 mg	ORAL	ANDA	30 sections
escitalopram oxalate	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6426	TABLET	10 mg	ORAL	ANDA	30 sections
escitalopram oxalate	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6427	TABLET	20 mg	ORAL	ANDA	30 sections
escitalopram oxalate	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6427	TABLET	20 mg	ORAL	ANDA	30 sections
escitalopram oxalate	HUMAN PRESCRIPTION DRUG LABEL	1	10544-224	TABLET	5 mg	ORAL	ANDA	29 sections
escitalopram oxalate	HUMAN PRESCRIPTION DRUG LABEL	1	10544-225	TABLET	10 mg	ORAL	ANDA	29 sections
escitalopram oxalate	HUMAN PRESCRIPTION DRUG LABEL	1	10544-230	TABLET	20 mg	ORAL	ANDA	29 sections
Escitalopram Oxalate	HUMAN PRESCRIPTION DRUG LABEL	1	10544-968	TABLET, FILM COATED	10 mg	ORAL	NDA authorized generic	32 sections
Escitalopram Oxalate	HUMAN PRESCRIPTION DRUG LABEL	1	10544-969	TABLET, FILM COATED	20 mg	ORAL	NDA authorized generic	32 sections
escitalopram oxalate	HUMAN PRESCRIPTION DRUG LABEL	1	13668-135	TABLET	5 mg	ORAL	ANDA	28 sections
escitalopram oxalate	HUMAN PRESCRIPTION DRUG LABEL	1	13668-135	TABLET	5 mg	ORAL	ANDA	28 sections
escitalopram oxalate	HUMAN PRESCRIPTION DRUG LABEL	1	13668-136	TABLET	10 mg	ORAL	ANDA	28 sections
escitalopram oxalate	HUMAN PRESCRIPTION DRUG LABEL	1	13668-136	TABLET	10 mg	ORAL	ANDA	28 sections