escitalopram 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1053 128196-01-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • escitalopram
  • (+)-(S)-Citalopram
  • (+)-Citalopram
  • (S)-Citalopram
  • S-(+)-Citalopram
  • seroplex
  • escitalopram oxalate
  • Molecular weight: 324.40
  • Formula: C20H21FN2O
  • CLOGP: 3.13
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 36.26
  • ALOGS: -4.74
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 8 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.88 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
fu (Fraction unbound in plasma) 0.36 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K
BA (Bioavailability) 100 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AKT2,AKT3,AXL,BRAF,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK12,MET,NTRK2,PDK2,PDK4,PRKDC,TEK,TGFBR1 23
kinase-selectivity-class EIF2AK3,PDK4 2
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.962 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
rat-kpuu-brain Rat brain Kpuu 0.320 % High 1

Approvals:

DateAgencyCompanyOrphan
Aug. 14, 2002 FDA FOREST LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Suicide attempt 1025.16 9.61 1053 206545 74346 90346503
Suicidal ideation 851.26 9.61 945 206653 72910 90347939
Intentional overdose 791.10 9.61 1024 206574 92810 90328039
Serotonin syndrome 718.27 9.61 636 206962 37251 90383598
Pemphigus 705.74 9.61 8 207590 326856 90093993
Completed suicide 629.20 9.61 1164 206434 143894 90276955
Drug interaction 602.90 9.61 1688 205910 274765 90146084
Hand deformity 600.24 9.61 17 207581 296345 90124504
Electrocardiogram QT prolonged 587.72 9.61 776 206822 71680 90349169
Systemic lupus erythematosus 572.75 9.61 76 207522 361820 90059029
Glossodynia 570.23 9.61 44 207554 321735 90099114
Synovitis 562.72 9.61 53 207545 329699 90091150
Somnolence 552.83 9.61 1372 206226 207712 90213137
Pericarditis 489.92 9.61 33 207565 270118 90150731
Duodenal ulcer perforation 489.12 9.61 3 207595 221285 90199564
Helicobacter infection 483.12 9.61 7 207591 226843 90194006
Contraindicated product administered 466.17 9.61 85 207513 320054 90100795
Wound 455.31 9.61 74 207524 302906 90117943
Sopor 453.75 9.61 407 207191 24237 90396612
Folliculitis 420.15 9.61 10 207588 204343 90216506
Arthropathy 411.63 9.61 162 207436 366080 90054769
Infusion related reaction 395.76 9.61 232 207366 416548 90004301
Joint swelling 378.91 9.61 357 207241 502943 89917906
Tremor 368.18 9.61 970 206628 152203 90268646
Rheumatoid factor positive 366.73 9.61 5 207593 171645 90249204
Muscle injury 361.78 9.61 9 207589 176645 90244204
Swelling 357.59 9.61 263 207335 418795 90002054
Treatment failure 329.18 9.61 142 207456 303786 90117063
Anxiety 328.66 9.61 1493 206105 308279 90112570
Hyponatraemia 323.27 9.61 848 206750 132690 90288159
Hepatic enzyme increased 317.40 9.61 219 207379 360517 90060332
Overdose 313.34 9.61 932 206666 156777 90264072
Impaired healing 310.51 9.61 77 207521 234122 90186727
Alopecia 304.11 9.61 414 207184 494657 89926192
Lower respiratory tract infection 294.73 9.61 103 207495 250556 90170293
Intentional self-injury 262.56 9.61 330 207268 29004 90391845
Stomatitis 260.43 9.61 153 207445 274545 90146304
Irritable bowel syndrome 260.27 9.61 76 207522 207372 90213477
Blister 248.93 9.61 137 207461 254861 90165988
Depression 245.13 9.61 1345 206253 299256 90121593
Mobility decreased 241.45 9.61 137 207461 250597 90170252
Fibromyalgia 231.95 9.61 91 207507 206178 90214671
Agitation 226.31 9.61 485 207113 66613 90354236
Toxicity to various agents 222.10 9.61 1269 206329 286577 90134272
Coma 216.83 9.61 500 207098 72132 90348717
C-reactive protein abnormal 215.80 9.61 21 207577 127408 90293441
Abdominal discomfort 215.04 9.61 485 207113 476843 89944006
Ill-defined disorder 212.15 9.61 79 207519 184812 90236037
Liver injury 211.19 9.61 64 207534 170503 90250346
Product substitution issue 210.02 9.61 232 207366 17776 90403073
Facet joint syndrome 209.54 9.61 3 207595 98386 90322463
Type 2 diabetes mellitus 209.02 9.61 102 207496 203142 90217707
Psoriatic arthropathy 208.29 9.61 133 207465 228202 90192647
Inappropriate antidiuretic hormone secretion 204.89 9.61 238 207360 19267 90401582
Lip dry 203.46 9.61 6 207592 100949 90319900
Rheumatoid arthritis 197.54 9.61 329 207269 362285 90058564
Fall 194.27 9.61 1818 205780 479992 89940857
Seizure 191.17 9.61 774 206824 151855 90268994
Therapeutic product effect decreased 190.31 9.61 213 207385 277358 90143491
Bursitis 185.03 9.61 38 207560 131616 90289233
Drug intolerance 177.93 9.61 485 207113 447106 89973743
Akathisia 177.71 9.61 170 207428 10989 90409860
Joint range of motion decreased 173.23 9.61 48 207550 135595 90285254
Drug abuse 168.53 9.61 492 207106 81855 90338994
Maternal exposure during pregnancy 168.52 9.61 358 207240 359705 90061144
Peripheral swelling 166.91 9.61 444 207154 412662 90008187
Reversible cerebral vasoconstriction syndrome 166.91 9.61 109 207489 4021 90416828
Drug hypersensitivity 162.91 9.61 532 207066 463077 89957772
Irritability 161.76 9.61 292 207306 35370 90385479
Discomfort 161.65 9.61 236 207362 274099 90146750
Withdrawal syndrome 160.98 9.61 227 207371 22297 90398552
Product use issue 156.92 9.61 325 207273 329594 90091255
C-reactive protein increased 156.89 9.61 112 207486 181277 90239572
Wheezing 155.32 9.61 190 207408 237890 90182959
Infection 153.30 9.61 380 207218 361714 90059135
Mania 152.82 9.61 175 207423 13949 90406900
Peripheral venous disease 152.75 9.61 10 207588 83911 90336938
Swollen tongue 146.76 9.61 325 207273 45631 90375218
Inflammation 145.84 9.61 117 207481 178475 90242374
Wound infection 142.87 9.61 34 207564 106368 90314481
Blood cholesterol increased 139.95 9.61 162 207436 207850 90212999
Dermatitis atopic 134.05 9.61 213 207385 23259 90397590
Depressed mood 133.96 9.61 331 207267 49891 90370958
Hypercholesterolaemia 132.04 9.61 34 207564 100858 90319991
Tardive dyskinesia 131.25 9.61 143 207455 10787 90410062
Dyskinesia 131.21 9.61 271 207327 36263 90384586
Crying 126.67 9.61 218 207380 25427 90395422
Torsade de pointes 125.17 9.61 164 207434 15018 90405831
Loss of consciousness 124.71 9.61 643 206955 139595 90281254
Restlessness 123.65 9.61 261 207337 35459 90385390
Pulmonary fibrosis 123.17 9.61 46 207552 107457 90313392
Panic attack 118.45 9.61 215 207383 26150 90394699
Galactorrhoea 114.50 9.61 91 207507 4581 90416268
Mydriasis 112.81 9.61 155 207443 14857 90405992
Hyperhidrosis 110.98 9.61 610 206988 135695 90285154
Musculoskeletal stiffness 109.16 9.61 333 207265 296199 90124650
Feeling abnormal 108.96 9.61 706 206892 166529 90254320
Mental disorder 108.24 9.61 233 207365 32085 90388764
Reversible airways obstruction 107.22 9.61 63 207535 1920 90418929
Vital capacity decreased 106.88 9.61 61 207537 1758 90419091
Major depression 106.32 9.61 123 207475 9912 90410937
Autoimmune disorder 106.07 9.61 23 207575 76721 90344128
Myelosuppression 105.10 9.61 4 207594 53587 90367262
Product administered to patient of inappropriate age 104.24 9.61 86 207512 4567 90416282
Muscle rigidity 103.42 9.61 145 207453 14164 90406685
Adjustment disorder with depressed mood 102.59 9.61 7 207591 56746 90364103
Arthralgia 100.95 9.61 1220 206378 777302 89643547
Sinusitis 100.57 9.61 424 207174 342664 90078185
Sciatica 99.54 9.61 54 207544 101328 90319521
Hip arthroplasty 99.11 9.61 26 207572 76182 90344667
Osteoarthritis 98.87 9.61 186 207412 195544 90225305
Psychomotor hyperactivity 98.86 9.61 134 207464 12679 90408170
Psychotic disorder 98.74 9.61 220 207378 31010 90389839
Sympathomimetic effect 98.49 9.61 29 207569 129 90420720
Hallucination, auditory 98.24 9.61 150 207448 15825 90405024
Lower limb fracture 98.02 9.61 36 207562 84977 90335872
Grip strength decreased 97.37 9.61 45 207553 92531 90328318
Hypersensitivity 97.24 9.61 626 206972 454051 89966798
Nasopharyngitis 96.79 9.61 542 207056 406562 90014287
Musculoskeletal pain 95.36 9.61 153 207445 171098 90249751
Foetal exposure during pregnancy 94.94 9.61 264 207334 42711 90378138
Sputum culture positive 94.83 9.61 61 207537 2192 90418657
Pulmonary embolism 94.41 9.61 567 207031 130253 90290596
General physical health deterioration 92.10 9.61 459 207139 354656 90066193
Oedema 91.25 9.61 202 207396 200093 90220756
Gastrointestinal disorder 90.41 9.61 294 207304 256393 90164456
Bone erosion 89.06 9.61 9 207589 53012 90367837
Aggression 87.86 9.61 191 207407 26477 90394372
Bronchial secretion retention 87.71 9.61 70 207528 3545 90417304
Syncope 87.59 9.61 562 207036 132101 90288748
Disturbance in attention 87.44 9.61 272 207326 46837 90374012
Vertigo 86.52 9.61 353 207245 69458 90351391
Hallucination 85.32 9.61 338 207260 65621 90355228
Extrapyramidal disorder 85.03 9.61 142 207456 16161 90404688
Emotional distress 83.75 9.61 228 207370 36434 90384415
Knee arthroplasty 83.58 9.61 43 207555 83139 90337710
Lung disorder 82.42 9.61 135 207463 149748 90271101
Tonsillar ulcer 82.27 9.61 30 207568 288 90420561
Prescribed overdose 82.15 9.61 62 207536 97563 90323286
Neuroleptic malignant syndrome 82.12 9.61 134 207464 14962 90405887
Suicidal behaviour 81.97 9.61 61 207537 2783 90418066
Rash 80.91 9.61 1310 206288 794790 89626059
Paranoia 80.50 9.61 122 207476 12786 90408063
Nightmare 80.19 9.61 163 207435 21562 90399287
Multiple sclerosis relapse 80.12 9.61 283 207315 52022 90368827
Deep vein thrombosis 79.97 9.61 418 207180 91202 90329647
Delusion 79.59 9.61 126 207472 13714 90407135
Long QT syndrome 78.93 9.61 69 207529 3968 90416881
Obesity 77.82 9.61 76 207522 105431 90315418
Intentional product use issue 76.66 9.61 248 207350 216644 90204205
Abnormal behaviour 75.62 9.61 163 207435 22465 90398384
Poisoning deliberate 74.77 9.61 135 207463 16351 90404498
Cholecystitis chronic 74.66 9.61 102 207496 9724 90411125
Angioedema 74.12 9.61 320 207278 64556 90356293
Cardiac arrest 73.92 9.61 452 207146 104483 90316366
Depressive symptom 73.90 9.61 75 207523 5210 90415639
Nail disorder 73.37 9.61 22 207576 59045 90361804
Rhabdomyolysis 73.15 9.61 271 207327 50985 90369864
Depressed level of consciousness 71.96 9.61 344 207254 72440 90348409
Onychomadesis 71.84 9.61 10 207588 45988 90374861
Complication of device insertion 71.37 9.61 103 207495 10333 90410516
Nausea 70.50 9.61 3161 204437 1107155 89313694
Drug withdrawal syndrome 70.03 9.61 183 207415 28540 90392309
Apathy 69.78 9.61 105 207493 10935 90409914
Foot deformity 69.21 9.61 25 207573 59626 90361223
Psychomotor retardation 68.87 9.61 69 207529 4720 90416129
Swelling face 68.84 9.61 368 207230 80984 90339865
Electrocardiogram QRS complex prolonged 67.88 9.61 84 207514 7264 90413585
Hyperreflexia 67.86 9.61 80 207518 6577 90414272
Sinus bradycardia 65.93 9.61 130 207468 16822 90404027
Lupus-like syndrome 64.79 9.61 16 207582 48830 90372019
Dysphonia 64.44 9.61 301 207297 62783 90358066
Adverse event 64.33 9.61 106 207492 117312 90303537
Hypersomnia 63.98 9.61 148 207450 21383 90399466
Pyrexia 63.70 9.61 1097 206501 659388 89761461
Hallucination, visual 63.49 9.61 154 207444 22938 90397911
Blepharospasm 63.04 9.61 24 207574 55421 90365428
Bradycardia 62.14 9.61 366 207232 83481 90337368
Breast cancer stage II 62.03 9.61 5 207593 35329 90385520
Alcoholism 61.94 9.61 43 207555 1757 90419092
Anger 61.77 9.61 112 207486 13608 90407241
Hostility 61.62 9.61 47 207551 2226 90418623
Cardio-respiratory arrest 61.39 9.61 297 207301 62843 90358006
Drug withdrawal syndrome neonatal 60.78 9.61 47 207551 2272 90418577
Dizziness 60.75 9.61 1773 205825 587511 89833338
Gastrointestinal procedural complication 60.42 9.61 27 207571 455 90420394
Sinus tachycardia 59.89 9.61 172 207426 28341 90392508
Muscle twitching 59.83 9.61 155 207443 24047 90396802
Small for dates baby 59.23 9.61 65 207533 4942 90415907
Pain 59.20 9.61 1785 205813 994556 89426293
Injury 58.95 9.61 242 207356 197107 90223742
Multiple sclerosis 58.53 9.61 168 207430 27672 90393177
Miosis 58.24 9.61 89 207509 9395 90411454
Head injury 57.81 9.61 180 207418 31008 90389841
Suspected suicide 57.65 9.61 89 207509 9479 90411370
Bruxism 57.54 9.61 60 207538 4303 90416546
Abnormal dreams 57.31 9.61 97 207501 11160 90409689
Hypertension 57.24 9.61 722 206876 456810 89964039
Exostosis 57.16 9.61 25 207573 53109 90367740
Mental status changes 57.01 9.61 228 207370 44451 90376398
Stiff person syndrome 56.63 9.61 26 207572 468 90420381
Disorientation 56.20 9.61 225 207373 43889 90376960
Lip ulceration 56.18 9.61 44 207554 2168 90418681
Respiratory arrest 56.06 9.61 186 207412 33125 90387724
Gait inability 55.62 9.61 162 207436 146294 90274555
Lower respiratory tract infection viral 55.52 9.61 32 207566 940 90419909
Osteoporosis 54.90 9.61 85 207513 96446 90324403
Red blood cell sedimentation rate increased 54.79 9.61 65 207533 82530 90338319
Taste disorder 54.51 9.61 37 207561 61509 90359340
Hypertonia 54.30 9.61 63 207535 5092 90415757
Finger deformity 54.18 9.61 6 207592 32891 90387958
Libido increased 53.86 9.61 39 207559 1705 90419144
Lethargy 53.68 9.61 286 207312 62853 90357996
Tachycardia 53.67 9.61 575 207023 157098 90263751
Physical deconditioning 53.63 9.61 43 207555 2192 90418657
Drug tolerance decreased 52.57 9.61 6 207592 32124 90388725
Anhedonia 52.34 9.61 94 207504 11337 90409512
Liver disorder 52.23 9.61 126 207472 121143 90299706
Clonus 51.94 9.61 65 207533 5685 90415164
Bradyphrenia 51.86 9.61 75 207523 7537 90413312
Live birth 51.68 9.61 63 207535 79044 90341805
Cerebral haematoma 51.30 9.61 56 207542 4233 90416616
Bipolar disorder 50.57 9.61 81 207517 8904 90411945
Tinnitus 48.77 9.61 212 207386 42890 90377959
Accidental overdose 47.70 9.61 158 207440 28115 90392734
Self-injurious ideation 47.63 9.61 47 207551 3156 90417693
Stress 46.64 9.61 333 207265 81062 90339787
Joint dislocation 46.36 9.61 22 207576 44560 90376289
Onychomycosis 46.28 9.61 14 207584 37362 90383487
Dystonia 46.06 9.61 112 207486 16707 90404142
Generalised tonic-clonic seizure 46.05 9.61 180 207418 34723 90386126
Upper-airway cough syndrome 46.03 9.61 105 207493 15030 90405819
Feeling of despair 45.77 9.61 46 207552 3158 90417691
Restless legs syndrome 45.70 9.61 134 207464 22336 90398513
Vision blurred 45.17 9.61 418 207180 109875 90310974
Product dose omission issue 44.85 9.61 927 206671 290760 90130089
Congenital absence of vertebra 44.42 9.61 12 207586 36 90420813
Arthritis 44.04 9.61 215 207383 167100 90253749
Balance disorder 43.92 9.61 376 207222 96704 90324145
Nervousness 43.62 9.61 174 207424 33882 90386967
Hypotension 43.32 9.61 1013 206585 324384 90096465
Urticaria 43.11 9.61 483 207115 312251 90108598
Prescribed underdose 42.71 9.61 66 207532 74953 90345896
Foreign body in reproductive tract 42.59 9.61 29 207569 1148 90419701
Gestational diabetes 42.18 9.61 82 207516 10500 90410349
Oculogyric crisis 41.83 9.61 39 207559 2440 90418409
Myoclonus 41.59 9.61 117 207481 19051 90401798
Dehydration 41.58 9.61 651 206947 193796 90227053
Activation syndrome 41.48 9.61 17 207581 229 90420620
Night sweats 40.92 9.61 154 207444 128612 90292237
Euphoric mood 40.87 9.61 56 207542 5353 90415496
Torticollis 40.79 9.61 39 207559 2519 90418330
Conversion disorder 40.60 9.61 36 207562 2110 90418739
Bundle branch block right 40.52 9.61 56 207542 5397 90415452
Alcohol use disorder 40.48 9.61 11 207587 34 90420815
Colitis microscopic 40.32 9.61 83 207515 11076 90409773
Eosinophil count increased 40.06 9.61 91 207507 12990 90407859
Headache 40.03 9.61 2385 205213 860361 89560488
Dyspepsia 39.69 9.61 278 207320 197882 90222967
Negative thoughts 39.62 9.61 27 207571 1070 90419779
Drug-induced liver injury 39.56 9.61 93 207505 90225 90330624
Post-traumatic neck syndrome 39.46 9.61 38 207560 2476 90418373
Drug ineffective 39.37 9.61 2688 204910 1381610 89039239
Laryngitis 39.26 9.61 35 207563 50718 90370131
Treatment noncompliance 39.10 9.61 227 207371 51500 90369349
Middle insomnia 39.08 9.61 105 207493 16646 90404203
Drug dependence 38.50 9.61 151 207447 29176 90391673
Sexual dysfunction 38.22 9.61 51 207547 4753 90416096
Affective disorder 38.16 9.61 66 207532 7727 90413122
Homicidal ideation 38.01 9.61 32 207566 1748 90419101
Febrile neutropenia 38.01 9.61 210 207388 158139 90262710
Bundle branch block left 37.59 9.61 66 207532 7819 90413030
Back injury 37.46 9.61 31 207567 46591 90374258
Insomnia 36.68 9.61 1012 206586 332462 90088387
Coeliac disease 36.67 9.61 29 207569 44581 90376268
Feeling jittery 36.52 9.61 97 207501 15274 90405575
Joint stiffness 36.10 9.61 78 207520 77964 90342885
Palpitations 36.09 9.61 475 207123 136253 90284596
Slow speech 35.72 9.61 32 207566 1901 90418948
Immunodeficiency 35.68 9.61 28 207570 43206 90377643
Multiple allergies 35.40 9.61 95 207503 15051 90405798
Somnambulism 34.85 9.61 56 207542 6172 90414677
Macular degeneration 34.75 9.61 22 207576 37948 90382901
Walking aid user 34.71 9.61 19 207579 35487 90385362
Therapeutic response unexpected 34.03 9.61 119 207479 21761 90399088
Emotional disorder 33.98 9.61 93 207505 14904 90405945
Orthostatic hypotension 33.88 9.61 187 207411 41640 90379209
Hepatic cirrhosis 33.81 9.61 58 207540 63195 90357654
Fear 33.68 9.61 99 207499 16523 90404326
Optic nerve injury 33.67 9.61 20 207578 622 90420227
Therapeutic product effect incomplete 33.66 9.61 283 207315 193613 90227236
Soft tissue injury 33.56 9.61 32 207566 2060 90418789
Pyramidal tract syndrome 33.53 9.61 19 207579 540 90420309
Chronic spontaneous urticaria 33.38 9.61 30 207568 1790 90419059
Unresponsive to stimuli 33.31 9.61 174 207424 37947 90382902
Respiratory disorder 33.23 9.61 61 207537 64755 90356094
Antidepressant discontinuation syndrome 33.22 9.61 13 207585 154 90420695
Drug screen positive 33.19 9.61 42 207556 3715 90417134
Subdural hygroma 33.03 9.61 15 207583 263 90420586
Hyperthermia 32.88 9.61 73 207525 10262 90410587
Concussion 32.69 9.61 76 207522 11015 90409834
Dysarthria 32.44 9.61 225 207373 54257 90366592
Yawning 32.38 9.61 24 207574 1088 90419761
Derealisation 32.34 9.61 27 207571 1458 90419391
Contusion 32.28 9.61 394 207204 250822 90170027
Adjustment disorder with mixed anxiety and depressed mood 32.21 9.61 12 207586 123 90420726
Substance abuse 32.17 9.61 50 207548 5356 90415493
Congenital genital malformation female 32.07 9.61 10 207588 56 90420793
Catatonia 31.92 9.61 53 207545 6003 90414846
Screaming 31.68 9.61 41 207557 3709 90417140
Intermenstrual bleeding 31.46 9.61 67 207531 9156 90411693
Mental impairment 31.45 9.61 97 207501 16623 90404226
Maternal drugs affecting foetus 31.13 9.61 48 207550 5107 90415742
Cytomegalovirus infection 31.11 9.61 11 207587 26591 90394258
Abdominal pain upper 30.87 9.61 556 207042 332118 90088731
Pneumonia 30.77 9.61 1173 206425 636886 89783963
Hypomania 30.77 9.61 65 207533 8832 90412017
Psychiatric symptom 30.65 9.61 57 207541 7061 90413788
Congenital pulmonary valve atresia 30.43 9.61 10 207588 68 90420781
COVID-19 30.14 9.61 549 207049 168294 90252555
Panic reaction 30.01 9.61 45 207553 4672 90416177
Haematoma 29.93 9.61 172 207426 38876 90381973
Postictal state 29.66 9.61 25 207573 1368 90419481
Respiratory disorder neonatal 29.53 9.61 25 207573 1376 90419473
Angle closure glaucoma 29.37 9.61 34 207564 2741 90418108
Poisoning 29.29 9.61 89 207509 15128 90405721
Gun shot wound 29.25 9.61 11 207587 116 90420733
Oral candidiasis 29.21 9.61 23 207575 35432 90385417
Hyperventilation 29.12 9.61 54 207544 6674 90414175
Alcohol use 28.95 9.61 27 207571 1690 90419159
Atrioventricular block 28.88 9.61 63 207535 8752 90412097
Nystagmus 28.81 9.61 56 207542 7171 90413678
Initial insomnia 28.77 9.61 65 207533 9245 90411604
Thermohypoaesthesia 28.76 9.61 11 207587 122 90420727
Sedation 28.72 9.61 199 207399 47972 90372877
Alcohol abuse 28.70 9.61 29 207569 2004 90418845
Impaired quality of life 28.64 9.61 117 207481 23027 90397822
Hypocoagulable state 28.62 9.61 26 207572 1573 90419276
Liver function test increased 28.60 9.61 99 207499 84756 90336093
Brain injury 28.49 9.61 58 207540 7680 90413169
Hypokalaemia 28.41 9.61 440 207158 130676 90290173
Dysgeusia 28.37 9.61 212 207386 52348 90368501
Hot flush 28.28 9.61 233 207365 59255 90361594
Device expulsion 28.08 9.61 175 207423 40711 90380138
Anticholinergic syndrome 28.02 9.61 33 207565 2710 90418139
Loss of libido 28.01 9.61 24 207574 1343 90419506
Heavy menstrual bleeding 28.00 9.61 107 207491 20423 90400426
Rheumatoid nodule 27.95 9.61 6 207592 20160 90400689
Disease progression 27.90 9.61 227 207371 156388 90264461
Off label use 27.74 9.61 2162 205436 1100090 89320759
Increased appetite 27.70 9.61 74 207524 11691 90409158
Morose 27.65 9.61 8 207590 33 90420816
Sepsis 27.49 9.61 271 207327 179543 90241306
Adverse reaction 27.48 9.61 17 207581 29695 90391154
Obsessive-compulsive disorder 27.28 9.61 42 207556 4462 90416387
Sight disability 27.05 9.61 11 207587 145 90420704
Drug ineffective for unapproved indication 26.99 9.61 252 207346 66392 90354457
Pneumocystis jirovecii pneumonia 26.94 9.61 8 207590 21608 90399241
Product administration interrupted 26.86 9.61 76 207522 12416 90408433
Pustular psoriasis 26.81 9.61 5 207593 18551 90402298
Ventricular dyskinesia 26.79 9.61 11 207587 149 90420700
Tearfulness 26.77 9.61 43 207555 4737 90416112
Sternal fracture 26.66 9.61 33 207565 2854 90417995
Caesarean section 26.31 9.61 98 207500 18479 90402370
Hyperdynamic left ventricle 26.16 9.61 13 207585 281 90420568
Urinary incontinence 25.93 9.61 161 207437 37405 90383444
Amenorrhoea 25.87 9.61 72 207526 11650 90409199
Constricted affect 25.86 9.61 6 207592 7 90420842
Libido decreased 25.81 9.61 33 207565 2949 90417900
Tongue biting 25.77 9.61 28 207570 2105 90418744
Alcoholic hangover 25.41 9.61 5 207593 0 90420849
Decreased interest 25.17 9.61 40 207558 4367 90416482
Device placement issue 25.14 9.61 27 207571 2003 90418846
Platelet aggregation inhibition 25.02 9.61 11 207587 178 90420671
Hepatitis infectious mononucleosis 24.86 9.61 10 207588 128 90420721
Thinking abnormal 24.86 9.61 71 207527 11661 90409188
Inappropriate schedule of product administration 24.85 9.61 482 207116 149451 90271398
Sputum culture 24.59 9.61 13 207585 321 90420528
Haemoglobin urine 24.45 9.61 10 207588 134 90420715
Cardiogenic shock 24.43 9.61 116 207482 24352 90396497
Ulcer haemorrhage 24.43 9.61 15 207583 26306 90394543
Immobilisation prolonged 24.38 9.61 10 207588 135 90420714
Sepsis neonatal 24.34 9.61 16 207582 597 90420252
Mood swings 24.32 9.61 103 207495 20599 90400250
Altered state of consciousness 24.23 9.61 139 207459 31393 90389456
Hyperphagia 24.10 9.61 31 207567 2787 90418062
Head banging 24.08 9.61 14 207584 418 90420431
Neonatal hypoxia 24.08 9.61 17 207581 714 90420135
Hypotonia 24.07 9.61 69 207529 11357 90409492
Large intestine anastomosis 23.98 9.61 7 207591 30 90420819
Poor quality sleep 23.89 9.61 116 207482 24577 90396272
Cyanosis neonatal 23.76 9.61 14 207584 429 90420420
Polydipsia 23.61 9.61 38 207560 4193 90416656
Fluid replacement 23.59 9.61 16 207582 629 90420220
Reflux gastritis 23.52 9.61 22 207576 1382 90419467
Myositis 23.46 9.61 13 207585 24115 90396734
Ventricular fibrillation 23.26 9.61 78 207520 13966 90406883
Parkinsonism 23.19 9.61 78 207520 13987 90406862
Complication of device removal 23.16 9.61 47 207551 6208 90414641
Tenosynovitis 23.14 9.61 3 207595 14564 90406285
Orbital swelling 23.11 9.61 8 207590 65 90420784
Central pain syndrome 23.04 9.61 16 207582 654 90420195
Extradural haematoma 23.01 9.61 26 207572 2042 90418807
Genital hypoaesthesia 23.01 9.61 6 207592 15 90420834
Asthma 23.00 9.61 403 207195 241757 90179092
Panniculitis 22.92 9.61 3 207595 14455 90406394
Biliary dyskinesia 22.87 9.61 29 207569 2570 90418279
Rapid eye movement sleep behaviour disorder 22.86 9.61 13 207585 372 90420477
Gallbladder disorder 22.86 9.61 98 207500 19705 90401144
Band sensation 22.83 9.61 20 207578 1153 90419696
Moaning 22.79 9.61 19 207579 1024 90419825
Disease recurrence 22.71 9.61 156 207442 37497 90383352
Rib fracture 22.64 9.61 120 207478 26315 90394534
Speech disorder 22.45 9.61 180 207418 45405 90375444
Persecutory delusion 22.43 9.61 32 207566 3176 90417673
Arrhythmia 22.42 9.61 170 207428 42162 90378687
Anorgasmia 22.41 9.61 16 207582 684 90420165
Skin ulcer 22.38 9.61 51 207547 50024 90370825
Rectal ulcer 22.31 9.61 22 207576 1476 90419373
Bradypnoea 22.22 9.61 39 207559 4619 90416230
Cognitive disorder 22.17 9.61 250 207348 69157 90351692
Infusion site reaction 22.05 9.61 8 207590 19031 90401818
Tonsillitis 21.92 9.61 49 207549 6920 90413929
Hypoaesthesia 21.88 9.61 550 207048 313660 90107189
Microcephaly 21.88 9.61 21 207577 1363 90419486
Gastroschisis 21.87 9.61 13 207585 405 90420444
Presyncope 21.75 9.61 136 207462 31669 90389180
Drowning 21.71 9.61 14 207584 505 90420344
Movement disorder 21.70 9.61 127 207471 28892 90391957
Uterine perforation 21.43 9.61 51 207547 7503 90413346
Cerebral haemorrhage 21.40 9.61 144 207454 34378 90386471
Atrioventricular block complete 21.40 9.61 60 207538 9751 90411098
Dysphoria 21.33 9.61 45 207553 6109 90414740
Bipolar II disorder 21.25 9.61 13 207585 427 90420422
Bipolar I disorder 21.19 9.61 25 207573 2057 90418792
Behaviour disorder 21.07 9.61 38 207560 4597 90416252
Compulsive shopping 21.07 9.61 16 207582 753 90420096
Cogwheel rigidity 21.00 9.61 25 207573 2077 90418772
Eczema 20.95 9.61 199 207399 52671 90368178
Dissociation 20.88 9.61 47 207551 6668 90414181
Red blood cell sedimentation rate abnormal 20.84 9.61 15 207583 24189 90396660
Cardiac hypertrophy 20.78 9.61 19 207579 1159 90419690
Blood prolactin increased 20.76 9.61 33 207565 3604 90417245
Catarrh 20.71 9.61 22 207576 1612 90419237
Cerebral thrombosis 20.63 9.61 23 207575 1780 90419069
Maternal exposure timing unspecified 20.61 9.61 13 207585 22470 90398379
Myalgia 20.53 9.61 536 207062 174589 90246260
Burns second degree 20.52 9.61 24 207574 1956 90418893
Subdural haematoma 20.48 9.61 84 207514 16561 90404288
Bile acid malabsorption 20.36 9.61 11 207587 284 90420565
Serum serotonin 20.33 9.61 4 207594 0 90420849
Ovarian granulosa cell tumour 20.32 9.61 6 207592 27 90420822
Orgasm abnormal 20.28 9.61 8 207590 97 90420752
Victim of sexual abuse 20.24 9.61 15 207583 680 90420169
Drug reaction with eosinophilia and systemic symptoms 20.07 9.61 167 207431 42591 90378258
Tracheal atresia 19.97 9.61 6 207592 29 90420820
Stoma obstruction 19.80 9.61 10 207588 224 90420625
Impulsive behaviour 19.67 9.61 22 207576 1708 90419141
Sebaceous gland infection 19.65 9.61 9 207589 161 90420688
Acute myopia 19.55 9.61 9 207589 163 90420686
Pulse absent 19.53 9.61 43 207555 6012 90414837
Social avoidant behaviour 19.52 9.61 31 207567 3382 90417467
Self-medication 19.47 9.61 30 207568 3190 90417659
Sleep talking 19.46 9.61 18 207580 1115 90419734
Disability 19.45 9.61 40 207558 40705 90380144
Respiratory tract infection 19.41 9.61 214 207384 58864 90361985
Prothrombin level increased 19.34 9.61 11 207587 315 90420534
Blood lactic acid 19.24 9.61 8 207590 112 90420737
Hallucinations, mixed 19.19 9.61 42 207556 5847 90415002
Polyarthritis 19.17 9.61 9 207589 18341 90402508
Hyperprolactinaemia 19.15 9.61 40 207558 5393 90415456
Mood altered 19.14 9.61 84 207514 17060 90403789
Psychomotor skills impaired 19.13 9.61 28 207570 2844 90418005
Retroplacental haematoma 19.11 9.61 9 207589 172 90420677
Tension 19.11 9.61 32 207566 3650 90417199
Drug resistance 19.10 9.61 25 207573 30424 90390425
Barotrauma 19.02 9.61 9 207589 174 90420675
Blood creatine phosphokinase increased 18.79 9.61 138 207460 33885 90386964
Partner stress 18.78 9.61 12 207586 426 90420423
Logorrhoea 18.77 9.61 27 207571 2700 90418149
Neutropenic sepsis 18.77 9.61 9 207589 18121 90402728
Withdrawal catatonia 18.65 9.61 9 207589 182 90420667
Dry mouth 18.55 9.61 303 207295 183756 90237093
Keratosis follicular 18.51 9.61 5 207593 15 90420834
Vascular stent stenosis 18.37 9.61 14 207584 662 90420187
Pain in extremity 18.36 9.61 844 206754 449685 89971164
Right ventricular dilatation 18.29 9.61 21 207577 1678 90419171
Pregnancy 18.26 9.61 220 207378 61827 90359022
Retinal ischaemia 18.25 9.61 12 207586 448 90420401
Enuresis 18.16 9.61 30 207568 3384 90417465
Convulsive threshold lowered 18.10 9.61 12 207586 454 90420395
Product administration error 18.08 9.61 113 207485 26310 90394539
Cytotoxic oedema 18.05 9.61 9 207589 196 90420653
Endometrial disorder 18.03 9.61 15 207583 806 90420043
Flight of ideas 18.01 9.61 12 207586 458 90420391
Incoherent 17.96 9.61 37 207561 4940 90415909
Gambling disorder 17.93 9.61 18 207580 1234 90419615
Aphasia 17.90 9.61 163 207435 42649 90378200
Amaurosis 17.89 9.61 15 207583 815 90420034
Trunk injury 17.82 9.61 5 207593 18 90420831
Atrial septal defect 17.61 9.61 50 207548 8184 90412665
Oromandibular dystonia 17.53 9.61 13 207585 590 90420259
Ecchymosis 17.45 9.61 65 207533 12258 90408591
Injection site mass 17.39 9.61 98 207500 21992 90398857
Hypervigilance 17.38 9.61 12 207586 486 90420363
Hypertensive cardiomyopathy 17.34 9.61 10 207588 294 90420555
Eosinophil count abnormal 17.33 9.61 15 207583 851 90419998
Multiple organ dysfunction syndrome 17.29 9.61 89 207509 68247 90352602
General symptom 17.27 9.61 6 207592 14662 90406187
Malignant neoplasm progression 17.20 9.61 159 207439 106711 90314138
Stoma site discharge 17.20 9.61 22 207576 1967 90418882
Hepatitis chronic active 17.17 9.61 7 207591 93 90420756
Learning disorder 17.15 9.61 15 207583 863 90419986
Enterococcus test positive 17.03 9.61 18 207580 1311 90419538
Adverse drug reaction 16.95 9.61 178 207420 116523 90304326
Talipes 16.81 9.61 20 207578 1660 90419189
Death 16.70 9.61 865 206733 455686 89965163
Electroencephalogram abnormal 16.64 9.61 32 207566 4064 90416785
Chronic sinusitis 16.58 9.61 18 207580 23784 90397065
Exercise lack of 16.58 9.61 11 207587 417 90420432
Post concussion syndrome 16.52 9.61 13 207585 645 90420204
Retching 16.43 9.61 87 207511 19072 90401777
Chest pain 16.41 9.61 583 207015 319062 90101787
Hepatic function abnormal 16.29 9.61 53 207545 46235 90374614
Bundle branch block 16.28 9.61 15 207583 924 90419925
Amyloid related imaging abnormality-oedema/effusion 16.22 9.61 15 207583 929 90419920
Snoring 16.08 9.61 36 207562 5090 90415759
Exposure via breast milk 16.05 9.61 23 207575 2292 90418557
Metastases to abdominal wall 16.01 9.61 8 207590 175 90420674
Dysmenorrhoea 16.01 9.61 34 207564 4638 90416211
Congenital diaphragmatic eventration 15.95 9.61 4 207594 8 90420841
Anti-actin antibody positive 15.95 9.61 4 207594 8 90420841
Abdominal wall haematoma 15.91 9.61 28 207570 3324 90417525
Focal dyscognitive seizures 15.88 9.61 27 207571 3117 90417732
Neutropenia 15.83 9.61 393 207205 224511 90196338
Metabolic acidosis 15.77 9.61 196 207402 55480 90365369
Lacunar infarction 15.76 9.61 28 207570 3349 90417500
Idiopathic orbital inflammation 15.66 9.61 9 207589 263 90420586
Incorrect dose administered 15.64 9.61 261 207337 78669 90342180
Drug level increased 15.56 9.61 113 207485 27649 90393200
Pelvic pain 15.48 9.61 73 207525 15284 90405565
Haemorrhagic stroke 15.44 9.61 41 207557 6455 90414394
Septic shock 15.44 9.61 121 207477 84039 90336810
Sleep-related eating disorder 15.43 9.61 15 207583 989 90419860
Cerebellar syndrome 15.43 9.61 30 207568 3842 90417007
Breast swelling 15.43 9.61 19 207579 1635 90419214
Attention-seeking behaviour 15.34 9.61 6 207592 71 90420778
Apnoea 15.34 9.61 52 207546 9362 90411487
Road traffic accident 15.29 9.61 165 207433 107461 90313388
Bradykinesia 15.29 9.61 42 207556 6746 90414103
Staring 15.28 9.61 19 207579 1651 90419198
Sialometaplasia 15.24 9.61 3 207595 0 90420849
Obsessive thoughts 15.24 9.61 12 207586 596 90420253
Labelled drug-drug interaction medication error 15.20 9.61 70 207528 14512 90406337
Parosmia 15.19 9.61 43 207555 7026 90413823
Proctitis 15.16 9.61 8 207590 15251 90405598
Muscle tightness 15.12 9.61 66 207532 13373 90407476
Metamyelocyte count increased 15.12 9.61 8 207590 198 90420651
Executive dysfunction 15.01 9.61 9 207589 285 90420564
Product substitution error 14.97 9.61 5 207593 36 90420813
Coma scale abnormal 14.91 9.61 37 207561 5589 90415260
Flat affect 14.91 9.61 19 207579 1692 90419157
Ear infection 14.90 9.61 96 207502 69679 90351170
Hypopnoea 14.90 9.61 32 207566 4399 90416450
Compulsions 14.87 9.61 8 207590 205 90420644
Device dislocation 14.79 9.61 123 207475 31359 90389490
Extrasystoles 14.78 9.61 37 207561 5620 90415229
Impaired driving ability 14.76 9.61 35 207563 5138 90415711
Potentiating drug interaction 14.76 9.61 37 207561 5625 90415224
Alcohol poisoning 14.76 9.61 20 207578 1892 90418957
Antipsychotic drug level increased 14.72 9.61 29 207569 3750 90417099
Joint hyperextension 14.70 9.61 10 207588 395 90420454
Creatinine renal clearance decreased 14.65 9.61 13 207585 18886 90401963
Embedded device 14.65 9.61 31 207567 4217 90416632
Disinhibition 14.65 9.61 15 207583 1053 90419796
Hypoglycaemia 14.59 9.61 233 207365 69615 90351234
Bone swelling 14.56 9.61 19 207579 1732 90419117
Sluggishness 14.56 9.61 38 207560 5921 90414928
Carcinoid syndrome 14.55 9.61 8 207590 214 90420635
Diplopia 14.48 9.61 114 207484 28600 90392249
Magnetic resonance imaging head abnormal 14.33 9.61 23 207575 2533 90418316
Eyelid haematoma 14.30 9.61 6 207592 86 90420763
Extensor plantar response 14.30 9.61 17 207581 1410 90419439
Disseminated intravascular coagulation 14.23 9.61 17 207581 21521 90399328
Superior sagittal sinus thrombosis 14.22 9.61 13 207585 793 90420056
Amyloid related imaging abnormality-microhaemorrhages and haemosiderin deposits 14.17 9.61 12 207586 661 90420188
Full blood count abnormal 14.13 9.61 137 207461 36460 90384389
Neonatal tachycardia 14.13 9.61 4 207594 15 90420834
Left ventricle outflow tract obstruction 14.12 9.61 10 207588 422 90420427
Vomiting projectile 14.08 9.61 19 207579 1790 90419059
Mucosal inflammation 14.05 9.61 76 207522 57549 90363300
Nervous system disorder 13.95 9.61 91 207507 21502 90399347
Gangrene 13.94 9.61 6 207592 12870 90407979
Heart rate increased 13.94 9.61 348 207250 112554 90308295
Skin necrosis 13.94 9.61 11 207587 16930 90403919
Congenital limb hyperextension 13.92 9.61 4 207594 16 90420833
Jaundice cholestatic 13.90 9.61 3 207595 10040 90410809
Mitral valve sclerosis 13.77 9.61 7 207591 159 90420690
Gingival pain 13.74 9.61 51 207547 9601 90411248
Impaired gastric emptying 13.73 9.61 62 207536 12747 90408102
Transplant rejection 13.73 9.61 6 207592 12752 90408097
Colour blindness 13.71 9.61 9 207589 335 90420514
Mucosal ulceration 13.69 9.61 15 207583 1138 90419711
Upper respiratory tract infection 13.68 9.61 209 207389 128109 90292740
Narrow anterior chamber angle 13.62 9.61 5 207593 49 90420800
Urinary hesitation 13.58 9.61 22 207576 2441 90418408
Clostridium bacteraemia 13.55 9.61 8 207590 246 90420603
Steroid dependence 13.52 9.61 21 207577 2248 90418601
Intensive care unit acquired weakness 13.51 9.61 14 207584 997 90419852
Panic disorder 13.48 9.61 25 207573 3090 90417759
Pollakiuria 13.46 9.61 125 207473 32880 90387969
Bone marrow failure 13.46 9.61 34 207564 32187 90388662
Psychotic disorder due to a general medical condition 13.43 9.61 8 207590 250 90420599
Urinary tract infection 13.36 9.61 841 206757 304791 90116058
Neonatal anuria 13.36 9.61 5 207593 52 90420797
Muscle contractions involuntary 13.31 9.61 24 207574 2904 90417945
Biliary colic 13.27 9.61 29 207569 4034 90416815
Wrong product procured 13.17 9.61 3 207595 3 90420846
Nephrolithiasis 13.14 9.61 171 207427 48914 90371935
Anterograde amnesia 13.11 9.61 11 207587 598 90420251
Arthropod bite 13.05 9.61 47 207551 8720 90412129
Product availability issue 13.05 9.61 42 207556 7362 90413487
Ear pain 13.04 9.61 78 207520 57624 90363225
Female genital tract fistula 13.02 9.61 13 207585 17855 90402994
Transposition of the great vessels 13.02 9.61 8 207590 265 90420584
Sensation of foreign body 12.98 9.61 38 207560 6328 90414521
Incision site haemorrhage 12.97 9.61 11 207587 607 90420242
Blunted affect 12.91 9.61 8 207590 269 90420580
Skin burning sensation 12.88 9.61 83 207515 19528 90401321
Ataxia 12.87 9.61 78 207520 17964 90402885
Flushing 12.85 9.61 279 207319 88212 90332637
Essential tremor 12.82 9.61 16 207582 1396 90419453
Gastrointestinal toxicity 12.75 9.61 3 207595 9464 90411385
Holoprosencephaly 12.74 9.61 4 207594 23 90420826
Nuchal rigidity 12.72 9.61 12 207586 762 90420087
Intelligence test abnormal 12.71 9.61 3 207595 4 90420845
Electrocardiogram abnormal 12.70 9.61 52 207546 10246 90410603
Dissociative disorder 12.70 9.61 11 207587 625 90420224
Spinal cord oedema 12.68 9.61 7 207591 189 90420660
Anxiety disorder 12.66 9.61 32 207566 4890 90415959
Exposure during pregnancy 12.65 9.61 433 207165 237977 90182872
Multimorbidity 12.61 9.61 11 207587 631 90420218
Uvulitis 12.60 9.61 4 207594 24 90420825
Illusion 12.57 9.61 15 207583 1249 90419600
Maternal exposure during breast feeding 12.56 9.61 37 207561 6183 90414666
Vaginal haemorrhage 12.54 9.61 118 207480 31153 90389696
Periorbital inflammation 12.51 9.61 7 207591 194 90420655
Rhythm idioventricular 12.50 9.61 9 207589 390 90420459
Dysphemia 12.49 9.61 24 207574 3046 90417803
Laryngectomy 12.46 9.61 4 207594 25 90420824
Stupor 12.42 9.61 34 207564 5448 90415401
Emotional poverty 12.40 9.61 9 207589 395 90420454
Feeling hot 12.32 9.61 249 207349 77759 90343090
Hunger 12.27 9.61 38 207560 6525 90414324
Impaired work ability 12.21 9.61 81 207517 19245 90401604
Cerebrovascular accident 12.21 9.61 370 207228 123163 90297686
Nephrogenic diabetes insipidus 12.19 9.61 13 207585 957 90419892
Renal impairment 12.18 9.61 169 207429 105252 90315597
Gallbladder injury 12.18 9.61 15 207583 1291 90419558
Obstructive airways disorder 12.12 9.61 101 207497 25768 90395081
Intervertebral disc protrusion 12.12 9.61 105 207493 27091 90393758
Red blood cells urine 12.10 9.61 10 207588 532 90420317
Ocular hypertension 12.10 9.61 17 207581 1663 90419186
Creatinine urine decreased 12.09 9.61 8 207590 302 90420547
Lipase increased 12.07 9.61 54 207544 11057 90409792
Convulsions local 12.07 9.61 4 207594 28 90420821
Belligerence 12.06 9.61 6 207592 130 90420719
Hypernatraemia 12.05 9.61 48 207550 9339 90411510
Vaginitis gardnerella 12.03 9.61 5 207593 70 90420779
Carotid artery thrombosis 12.01 9.61 3 207595 9089 90411760
Trichotillomania 11.98 9.61 6 207592 132 90420717
Wound healing normal 11.96 9.61 3 207595 6 90420843
Atrophy of globe 11.96 9.61 3 207595 6 90420843
Ventricular extrasystoles 11.93 9.61 61 207537 13189 90407660
Sleep deficit 11.90 9.61 13 207585 983 90419866
Tachyphrenia 11.90 9.61 17 207581 1689 90419160
Acute myeloid leukaemia 11.90 9.61 18 207580 20622 90400227
Pre-existing condition improved 11.86 9.61 47 207551 9122 90411727
Polyuria 11.83 9.61 50 207548 9990 90410859
Thrombotic thrombocytopenic purpura 11.81 9.61 28 207570 4110 90416739
Thrombocytopenia 11.80 9.61 376 207222 208349 90212500
Tonic clonic movements 11.78 9.61 17 207581 1705 90419144
Pupillary reflex impaired 11.74 9.61 21 207577 2524 90418325
Pulseless electrical activity 11.73 9.61 46 207552 8886 90411963
Pupil fixed 11.72 9.61 19 207579 2109 90418740
Bladder dilatation 11.70 9.61 13 207585 1002 90419847
Cluster headache 11.69 9.61 12 207586 845 90420004
Arterial occlusive disease 11.68 9.61 7 207591 12439 90408410
Livedo reticularis 11.65 9.61 25 207573 3434 90417415
Sinus arrest 11.60 9.61 19 207579 2127 90418722
Cor pulmonale acute 11.59 9.61 9 207589 438 90420411
Micturition disorder 11.55 9.61 23 207575 2997 90417852
Electrocardiogram P wave abnormal 11.55 9.61 7 207591 226 90420623
Fibrin D dimer increased 11.53 9.61 33 207565 5427 90415422
Product quality issue 11.52 9.61 121 207477 79204 90341645
Monocyte count decreased 11.47 9.61 21 207577 2570 90418279
Cerebral amyloid angiopathy 11.47 9.61 7 207591 229 90420620
Cardiac failure 11.45 9.61 179 207419 109317 90311532
Resting tremor 11.39 9.61 12 207586 871 90419978
Economic problem 11.38 9.61 24 207574 3257 90417592
Food allergy 11.34 9.61 26 207572 25452 90395397
Ventricular tachycardia 11.33 9.61 96 207502 24612 90396237
CSF pressure increased 11.32 9.61 6 207592 149 90420700
Interstitial lung disease 11.32 9.61 116 207482 76289 90344560
Tobacco abuse 11.29 9.61 11 207587 727 90420122
Bronchopulmonary aspergillosis 11.29 9.61 6 207592 11392 90409457
Lipohypertrophy 11.28 9.61 11 207587 728 90420121
Methaemoglobinaemia 11.28 9.61 27 207571 3988 90416861
Housebound 11.20 9.61 7 207591 239 90420610
Urinary retention 11.18 9.61 134 207464 37610 90383239
Bronchial hyperreactivity 11.16 9.61 18 207580 1990 90418859
Congenital tracheomalacia 11.10 9.61 4 207594 37 90420812
Violence-related symptom 11.06 9.61 10 207588 601 90420248
Pancreatic carcinoma recurrent 11.04 9.61 5 207593 87 90420762
Pulmonary infarction 11.03 9.61 22 207576 2870 90417979
Anorectal disorder 11.01 9.61 18 207580 2013 90418836
Breast discharge 11.00 9.61 14 207584 1245 90419604
Fibrous histiocytoma 10.94 9.61 10 207588 610 90420239
Gamma-glutamyltransferase increased 10.92 9.61 134 207464 37818 90383031
Ovarian vein thrombosis 10.89 9.61 5 207593 90 90420759
Depression suicidal 10.89 9.61 18 207580 2031 90418818
Dysplastic naevus 10.87 9.61 7 207591 252 90420597
Selective eating disorder 10.86 9.61 18 207580 2035 90418814
Encephalitis autoimmune 10.83 9.61 18 207580 2040 90418809
Oesophageal atresia 10.80 9.61 10 207588 620 90420229
Overweight 10.77 9.61 34 207564 5900 90414949
Back disorder 10.74 9.61 27 207571 25604 90395245
Parotid gland enlargement 10.74 9.61 12 207586 931 90419918
Dextrocardia 10.74 9.61 4 207594 41 90420808
Investigation abnormal 10.72 9.61 19 207579 2268 90418581
Functional residual capacity increased 10.69 9.61 5 207593 94 90420755
Product dose omission in error 10.67 9.61 82 207516 20421 90400428
Presbyopia 10.67 9.61 10 207588 630 90420219
Surgery 10.64 9.61 153 207445 44734 90376115
Neuromyelitis optica spectrum disorder 10.62 9.61 15 207583 1475 90419374
Electrocardiogram U wave present 10.60 9.61 5 207593 96 90420753
Apallic syndrome 10.59 9.61 11 207587 785 90420064
Tubulointerstitial nephritis and uveitis syndrome 10.56 9.61 7 207591 265 90420584
Diabetes mellitus 10.55 9.61 208 207390 64667 90356182
Haematotoxicity 10.49 9.61 8 207590 12527 90408322
Idiosyncratic drug reaction 10.45 9.61 12 207586 959 90419890
Drug metabolite level high 10.44 9.61 3 207595 12 90420837
Wrong patient received product 10.44 9.61 24 207574 3453 90417396
Periorbital haematoma 10.42 9.61 11 207587 800 90420049
Therapeutic drug monitoring analysis not performed 10.41 9.61 14 207584 1315 90419534
Intensive care 10.37 9.61 14 207584 1320 90419529
Laboratory test abnormal 10.31 9.61 55 207543 41799 90379050
Feeling guilty 10.30 9.61 10 207588 658 90420191
Dopamine dysregulation syndrome 10.30 9.61 6 207592 180 90420669
Fluid retention 10.25 9.61 141 207457 87950 90332899
Congenital melanocytic naevus 10.25 9.61 3 207595 13 90420836
Hepatitis 10.23 9.61 108 207490 70631 90350218
Device breakage 10.20 9.61 61 207537 13983 90406866
Metastases to lung 10.16 9.61 13 207585 15978 90404871
External ear cellulitis 10.13 9.61 7 207591 284 90420565
Gastrointestinal sounds abnormal 10.12 9.61 28 207570 4515 90416334
Pathogen resistance 10.12 9.61 3 207595 8112 90412737
Cyclic vomiting syndrome 10.09 9.61 6 207592 187 90420662
Gastrointestinal ischaemia 10.09 9.61 6 207592 187 90420662
Optic atrophy 10.08 9.61 15 207583 1546 90419303
Food craving 10.08 9.61 17 207581 1950 90418899
Impaired self-care 10.07 9.61 16 207582 1746 90419103
Accommodation disorder 10.01 9.61 8 207590 406 90420443
Vitamin D decreased 10.00 9.61 54 207544 11925 90408924
Drug tolerance 9.97 9.61 16 207582 17900 90402949
Family stress 9.97 9.61 10 207588 685 90420164
Cholestasis 9.95 9.61 127 207471 36172 90384677
Blood pressure diastolic decreased 9.94 9.61 30 207568 26796 90394053
Long QT syndrome congenital 9.94 9.61 5 207593 111 90420738
Ear discomfort 9.93 9.61 48 207550 10152 90410697
Inappropriate affect 9.93 9.61 12 207586 1013 90419836
Retrograde amnesia 9.90 9.61 9 207589 545 90420304
Basilar migraine 9.89 9.61 4 207594 52 90420797
Heterophoria 9.89 9.61 4 207594 52 90420797
Neck injury 9.88 9.61 19 207579 2413 90418436
Agitation neonatal 9.87 9.61 9 207589 547 90420302
Distractibility 9.83 9.61 9 207589 550 90420299
Hepatotoxicity 9.83 9.61 63 207535 45779 90375070
Influenza like illness 9.81 9.61 248 207350 80363 90340486
Throat tightness 9.78 9.61 107 207491 29377 90391472
Substance-induced psychotic disorder 9.76 9.61 21 207577 2891 90417958
Electrocardiogram T wave abnormal 9.72 9.61 20 207578 2668 90418181
Congenital megaureter 9.70 9.61 5 207593 117 90420732
Pruritus 9.70 9.61 1089 206509 540436 89880413
Blood alcohol increased 9.69 9.61 9 207589 560 90420289
Extra dose administered 9.67 9.61 44 207554 9074 90411775
Food intolerance 9.65 9.61 25 207573 3877 90416972
Post-traumatic stress disorder 9.65 9.61 36 207562 6792 90414057
Breast cancer stage I 9.63 9.61 5 207593 9619 90411230
Cerebral cyst 9.63 9.61 7 207591 308 90420541
Lung diffusion disorder 9.62 9.61 5 207593 119 90420730
Cytarabine syndrome 9.62 9.61 4 207594 56 90420793
Hypotonia neonatal 9.61 9.61 14 207584 1416 90419433

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 547.22 10.66 465 98675 25380 42496815
Completed suicide 487.20 10.66 834 98306 95631 42426564
Suicide attempt 437.89 10.66 538 98602 45562 42476633
Suicidal ideation 388.05 10.66 518 98622 47643 42474552
Intentional overdose 380.66 10.66 531 98609 50925 42471270
Anxiety 277.27 10.66 750 98390 117810 42404385
Depression 221.84 10.66 665 98475 110698 42411497
Agitation 209.05 10.66 462 98678 63852 42458343
Foetal exposure during pregnancy 197.62 10.66 377 98763 46934 42475261
Spirometry abnormal 177.93 10.66 124 99016 5022 42517173
Conjunctivitis allergic 166.94 10.66 126 99014 5785 42516410
Somnolence 164.46 10.66 707 98433 140398 42381797
Mycotic allergy 162.47 10.66 115 99025 4776 42517419
Mite allergy 161.53 10.66 116 99024 4930 42517265
Dust allergy 155.80 10.66 116 99024 5216 42516979
Febrile neutropenia 143.92 10.66 132 99008 185571 42336624
Aggression 137.56 10.66 312 98828 43851 42478344
Tremor 137.11 10.66 516 98624 96413 42425782
Intentional self-injury 129.25 10.66 168 98972 15034 42507161
Major depression 128.47 10.66 104 99036 5294 42516901
Normochromic normocytic anaemia 115.44 10.66 123 99017 8908 42513287
Overdose 115.38 10.66 518 98622 104746 42417449
Confusional state 115.22 10.66 725 98415 166872 42355323
Sleep terror 114.21 10.66 76 99064 2850 42519345
Withdrawal syndrome 109.92 10.66 153 98987 14622 42507573
Pulmonary vasculitis 109.13 10.66 101 99039 6165 42516030
Electrocardiogram QT prolonged 108.57 10.66 300 98840 47645 42474550
Sopor 107.75 10.66 143 98997 13059 42509136
Sexual dysfunction 102.42 10.66 101 99039 6674 42515521
Sleep disorder due to a general medical condition 98.74 10.66 159 98981 17294 42504901
Total lung capacity abnormal 98.20 10.66 82 99058 4361 42517834
Drug interaction 96.21 10.66 996 98144 266003 42256192
Mania 95.08 10.66 120 99020 10427 42511768
Neuritis 94.54 10.66 93 99047 6127 42516068
Disturbance in attention 94.10 10.66 212 98928 29654 42492541
Neutropenia 92.64 10.66 204 98936 199227 42322968
Eosinophilic granulomatosis with polyangiitis 90.42 10.66 106 99034 8532 42513663
Multiple organ dysfunction syndrome 89.04 10.66 58 99082 96977 42425218
Off label use 88.74 10.66 1005 98135 637330 41884865
Panic attack 86.11 10.66 117 99023 10928 42511267
Pneumonia 85.64 10.66 603 98537 421546 42100649
Nodule 84.71 10.66 124 99016 12410 42509785
Insomnia 84.61 10.66 517 98623 117736 42404459
Neurological symptom 82.74 10.66 109 99031 9882 42512313
Dyskinesia 80.85 10.66 181 98959 25209 42496986
Intrusive thoughts 80.81 10.66 33 99107 433 42521762
Septic shock 79.84 10.66 58 99082 91614 42430581
Paranoia 79.64 10.66 128 99012 13898 42508297
Loss of personal independence in daily activities 78.67 10.66 275 98865 49541 42472654
Rapid eye movement sleep behaviour disorder 78.41 10.66 29 99111 286 42521909
Muscle rigidity 78.19 10.66 117 99023 11942 42510253
Steroid dependence 77.98 10.66 87 99053 6635 42515560
Interstitial lung disease 77.45 10.66 43 99097 78419 42443776
Poisoning deliberate 76.96 10.66 106 99034 10028 42512167
Restlessness 76.35 10.66 193 98947 29056 42493139
Drug withdrawal syndrome 75.89 10.66 160 98980 21389 42500806
Sepsis 74.82 10.66 227 98913 199107 42323088
Thrombocytopenia 74.82 10.66 212 98928 190067 42332128
Impaired work ability 72.32 10.66 113 99027 11978 42510217
Burns second degree 70.89 10.66 79 99061 6017 42516178
Malignant neoplasm progression 70.60 10.66 89 99051 108311 42413884
Catarrh 70.35 10.66 78 99062 5908 42516287
Nightmare 69.46 10.66 169 98971 24843 42497352
Loss of libido 68.55 10.66 57 99083 3013 42519182
Parosmia 66.94 10.66 86 99054 7605 42514590
Fall 65.98 10.66 834 98306 233686 42288509
Myelosuppression 64.03 10.66 9 99131 40452 42481743
Anaemia 63.47 10.66 387 98753 279891 42242304
Pyrexia 63.28 10.66 599 98541 393443 42128752
Maternal drugs affecting foetus 63.24 10.66 60 99080 3779 42518416
Activation syndrome 62.82 10.66 21 99119 149 42522046
Irritability 62.66 10.66 175 98965 27953 42494242
Gingival pain 61.75 10.66 87 99053 8407 42513788
Respiratory symptom 61.21 10.66 100 99040 11006 42511189
Hypopnoea 60.69 10.66 83 99057 7799 42514396
Hyperreflexia 60.61 10.66 57 99083 3550 42518645
Sedation 60.56 10.66 182 98958 30293 42491902
Arteriosclerosis coronary artery 60.42 10.66 134 99006 18543 42503652
Coma 59.71 10.66 265 98875 53289 42468906
Anger 59.65 10.66 108 99032 12910 42509285
Apathy 59.48 10.66 85 99055 8321 42513874
Abulia 59.45 10.66 30 99110 660 42521535
Antineutrophil cytoplasmic antibody positive 58.54 10.66 61 99079 4304 42517891
Forced expiratory volume decreased 58.23 10.66 80 99060 7550 42514645
Renal failure 57.31 10.66 159 98981 143567 42378628
Medication error 56.71 10.66 188 98952 32966 42489229
Physical deconditioning 56.52 10.66 46 99094 2359 42519836
Homicidal ideation 56.50 10.66 49 99091 2745 42519450
Arteriosclerosis 55.88 10.66 127 99013 17862 42504333
Libido decreased 55.77 10.66 64 99076 5034 42517161
Drug withdrawal syndrome neonatal 55.68 10.66 60 99080 4401 42517794
Systemic lupus erythematosus 55.57 10.66 87 99053 9237 42512958
Tachyphrenia 55.26 10.66 37 99103 1402 42520793
Parkinsonism 55.00 10.66 93 99047 10530 42511665
Cardiac murmur 54.78 10.66 103 99037 12672 42509523
Depressed mood 53.58 10.66 147 98993 23237 42498958
Palpitations 53.37 10.66 247 98893 50550 42471645
Reduced facial expression 53.13 10.66 37 99103 1496 42520699
Alcohol poisoning 52.73 10.66 76 99064 7498 42514697
Renal impairment 52.58 10.66 111 99029 110117 42412078
Mood swings 52.11 10.66 82 99058 8744 42513451
Electrocardiogram QRS complex prolonged 52.08 10.66 66 99074 5757 42516438
Abnormal dreams 51.85 10.66 79 99061 8192 42514003
Erectile dysfunction 51.61 10.66 151 98989 24762 42497433
Akathisia 49.54 10.66 88 99052 10363 42511832
Disease progression 49.40 10.66 170 98970 143486 42378709
Small for dates baby 49.22 10.66 61 99079 5202 42516993
Resting tremor 49.01 10.66 30 99110 971 42521224
Capillaritis 48.99 10.66 41 99099 2187 42520008
Hypomania 48.74 10.66 43 99097 2465 42519730
Pulmonary alveolar haemorrhage 48.71 10.66 107 99033 14709 42507486
Anorgasmia 47.95 10.66 31 99109 1106 42521089
Tardive dyskinesia 47.51 10.66 69 99071 6855 42515340
Mydriasis 47.03 10.66 78 99062 8692 42513503
Impaired quality of life 46.18 10.66 102 99038 14075 42508120
Loss of consciousness 46.11 10.66 370 98770 91984 42430211
Bradykinesia 46.08 10.66 60 99080 5376 42516819
Gun shot wound 45.53 10.66 29 99111 1008 42521187
Foetal malformation 45.23 10.66 17 99123 176 42522019
Tongue thrust 45.01 10.66 12 99128 33 42522162
Infusion related reaction 44.95 10.66 45 99095 60761 42461434
Alcoholism 44.88 10.66 44 99096 2886 42519309
Respiratory disorder neonatal 44.87 10.66 37 99103 1933 42520262
Product substitution issue 44.69 10.66 88 99052 11202 42510993
Infantile back arching 44.45 10.66 14 99126 80 42522115
Suspected suicide 44.33 10.66 63 99077 6136 42516059
Full blood count abnormal 43.80 10.66 161 98979 29715 42492480
Sleep disorder 43.46 10.66 224 98916 47871 42474324
Blood creatinine increased 42.87 10.66 123 99017 109880 42412315
Hallucination, visual 42.20 10.66 126 99014 20894 42501301
Inappropriate antidiuretic hormone secretion 41.97 10.66 108 99032 16433 42505762
Psychomotor hyperactivity 41.68 10.66 84 99056 10874 42511321
Cytokine release syndrome 41.67 10.66 26 99114 44501 42477694
Clonus 41.59 10.66 46 99094 3474 42518721
Chest injury 41.04 10.66 34 99106 1788 42520407
Bone marrow failure 40.88 10.66 13 99127 33080 42489115
Neuroleptic malignant syndrome 40.57 10.66 126 99014 21346 42500849
Acute kidney injury 40.21 10.66 607 98533 366730 42155465
Anhedonia 39.70 10.66 67 99073 7573 42514622
Hyperhidrosis 39.56 10.66 352 98788 90160 42432035
Pancytopenia 39.35 10.66 141 98999 117602 42404593
Seizure 39.21 10.66 441 98699 120120 42402075
Tinnitus 39.16 10.66 152 98988 28786 42493409
Cardiac failure 38.41 10.66 124 99016 106732 42415463
Platelet count decreased 38.16 10.66 179 98961 138402 42383793
Respiratory failure 37.99 10.66 161 98979 127971 42394224
Atrial septal defect 37.95 10.66 67 99073 7852 42514343
Craniosynostosis 37.69 10.66 19 99121 417 42521778
Rhinitis 37.69 10.66 85 99055 11892 42510303
Ascites 37.44 10.66 46 99094 56632 42465563
Self esteem decreased 37.25 10.66 20 99120 502 42521693
Catatonia 36.88 10.66 58 99082 6181 42516014
Myoclonus 36.86 10.66 105 99035 16960 42505235
Abnormal behaviour 36.66 10.66 140 99000 26311 42495884
Pregnancy 36.55 10.66 16 99124 252 42521943
Extrapyramidal disorder 36.44 10.66 102 99038 16310 42505885
Bipolar disorder 35.94 10.66 45 99095 3877 42518318
Hallucination 35.89 10.66 243 98897 57264 42464931
Cogwheel rigidity 35.24 10.66 31 99109 1770 42520425
Parkinsonian gait 35.21 10.66 20 99120 562 42521633
Delusion 35.13 10.66 94 99046 14640 42507555
Thinking abnormal 34.85 10.66 61 99079 7100 42515095
Social avoidant behaviour 34.74 10.66 41 99099 3323 42518872
Condition aggravated 34.64 10.66 822 98318 259932 42262263
Hallucination, auditory 34.61 10.66 94 99046 14770 42507425
Oedema peripheral 34.46 10.66 181 98959 135895 42386300
Mental disorder 34.25 10.66 106 99034 17923 42504272
Homicide 33.87 10.66 23 99117 892 42521303
Infantile apnoea 33.83 10.66 25 99115 1111 42521084
Amnesia 33.43 10.66 143 98997 28294 42493901
Pruritus 33.24 10.66 280 98860 188491 42333704
Infection 33.10 10.66 141 98999 111927 42410268
Agitation neonatal 32.90 10.66 27 99113 1401 42520794
Postictal psychosis 32.78 10.66 14 99126 207 42521988
Impulsive behaviour 32.72 10.66 34 99106 2391 42519804
Neuropathy peripheral 32.70 10.66 124 99016 101729 42420466
Toxic epidermal necrolysis 32.17 10.66 11 99129 26739 42495456
Device dislocation 32.17 10.66 62 99078 7769 42514426
Anencephaly 31.69 10.66 12 99128 127 42522068
Mucosal inflammation 31.64 10.66 41 99099 49333 42472862
Migraine 31.59 10.66 130 99010 25284 42496911
Bronchopulmonary aspergillosis 31.50 10.66 4 99136 19425 42502770
Stress 31.38 10.66 193 98947 44019 42478176
Drug screen positive 31.05 10.66 43 99097 4088 42518107
Electrocardiogram QT interval 31.00 10.66 9 99131 37 42522158
Hypothyroidism 30.78 10.66 152 98988 31932 42490263
Reversible cerebral vasoconstriction syndrome 30.78 10.66 20 99120 720 42521475
Death 30.77 10.66 848 98292 470337 42051858
Cognitive disorder 30.76 10.66 159 98981 34013 42488182
Tumour lysis syndrome 30.72 10.66 7 99133 22224 42499971
Breath holding 30.63 10.66 11 99129 99 42522096
Skin dystrophy 30.63 10.66 7 99133 7 42522188
Suture rupture 30.48 10.66 17 99123 461 42521734
Colitis ulcerative 30.28 10.66 131 99009 26044 42496151
Hypophosphataemia 30.16 10.66 6 99134 20939 42501256
Disseminated intravascular coagulation 30.16 10.66 10 99130 24784 42497411
Alcohol use 29.89 10.66 35 99105 2813 42519382
Vertigo 29.67 10.66 158 98982 34189 42488006
Vasculitis 29.42 10.66 102 99038 18292 42503903
Urinary retention 29.16 10.66 183 98957 42031 42480164
Erythema 29.08 10.66 142 98998 108651 42413544
Hypertonia 28.88 10.66 46 99094 4955 42517240
Bradyphrenia 28.48 10.66 47 99093 5215 42516980
Feeling jittery 28.24 10.66 43 99097 4455 42517740
Joint swelling 28.02 10.66 74 99066 67948 42454247
Cough 27.94 10.66 272 98868 177831 42344364
Mental impairment 27.79 10.66 77 99063 12240 42509955
Anal incontinence 27.78 10.66 65 99075 9316 42512879
Metabolic function test abnormal 27.78 10.66 13 99127 241 42521954
Abdominal pain 27.78 10.66 296 98844 190175 42332020
Painful respiration 27.66 10.66 24 99116 1345 42520850
Wheezing 27.61 10.66 220 98920 54561 42467634
Dissociative disorder 27.55 10.66 18 99122 654 42521541
Poor quality sleep 27.51 10.66 65 99075 9375 42512820
Swollen tongue 27.50 10.66 110 99030 21121 42501074
Cytomegalovirus infection 27.39 10.66 21 99119 32285 42489910
Congenital ureteropelvic junction obstruction 27.27 10.66 9 99131 61 42522134
Walking aid user 27.04 10.66 32 99108 2601 42519594
Accidental overdose 27.03 10.66 134 99006 28196 42493999
Persecutory delusion 26.64 10.66 37 99103 3527 42518668
Urticaria 26.53 10.66 86 99054 73950 42448245
Pleural effusion 26.44 10.66 126 99014 97040 42425155
Swelling 26.38 10.66 55 99085 54830 42467365
Cardiac failure congestive 26.33 10.66 106 99034 85496 42436699
Aspergillus infection 26.32 10.66 3 99137 15834 42506361
Patient elopement 26.04 10.66 11 99129 158 42522037
Pneumocystis jirovecii pneumonia 26.01 10.66 13 99127 25168 42497027
Neonatal respiratory distress 25.99 10.66 20 99120 945 42521250
Sleep talking 25.96 10.66 17 99123 620 42521575
Gambling disorder 25.96 10.66 26 99114 1750 42520445
Acetabulum fracture 25.92 10.66 15 99125 437 42521758
Soft tissue disorder 25.89 10.66 19 99121 835 42521360
Derealisation 25.87 10.66 19 99121 836 42521359
Abnormal clotting factor 25.77 10.66 9 99131 74 42522121
Poor sucking reflex 25.66 10.66 14 99126 363 42521832
Palmar-plantar erythrodysaesthesia syndrome 25.57 10.66 8 99132 20574 42501621
Memory impairment 25.48 10.66 202 98938 50020 42472175
Stomatitis 25.42 10.66 49 99091 50280 42471915
Neutrophil count decreased 25.36 10.66 70 99070 63345 42458850
Choanal stenosis 25.33 10.66 5 99135 0 42522195
Cerebral haematoma 25.01 10.66 46 99094 5564 42516631
Delirium 24.89 10.66 208 98932 52311 42469884
Emotional disorder 24.73 10.66 49 99091 6265 42515930
Haemophagocytic lymphohistiocytosis 24.66 10.66 6 99134 18216 42503979
White blood cell count decreased 24.62 10.66 153 98987 110243 42411952
Hypersensitivity 24.61 10.66 86 99054 72284 42449911
Consciousness fluctuating 24.47 10.66 22 99118 1293 42520902
Legal problem 24.37 10.66 10 99130 133 42522062
Orgasm abnormal 24.03 10.66 10 99130 138 42522057
Bradycardia neonatal 24.00 10.66 22 99118 1326 42520869
Lactic acidosis 23.80 10.66 43 99097 45218 42476977
Bacterial infection 23.79 10.66 18 99122 27861 42494334
Therapeutic product effect incomplete 23.73 10.66 261 98879 70678 42451517
Neonatal seizure 23.61 10.66 15 99125 519 42521676
Libido increased 23.60 10.66 19 99121 959 42521236
Postural orthostatic tachycardia syndrome 23.47 10.66 10 99130 147 42522048
Trisomy 18 23.46 10.66 18 99122 847 42521348
Disorientation 23.44 10.66 155 98985 36234 42485961
Psychomotor retardation 23.42 10.66 39 99101 4360 42517835
Diarrhoea 23.40 10.66 857 98283 459992 42062203
Orthostatic hypotension 23.32 10.66 136 99004 30434 42491761
Feeling guilty 23.03 10.66 13 99127 361 42521834
Rabbit syndrome 23.00 10.66 7 99133 35 42522160
Panic reaction 22.88 10.66 24 99116 1706 42520489
Leukopenia 22.71 10.66 93 99047 74653 42447542
Generalised tonic-clonic seizure 22.54 10.66 121 99019 26258 42495937
Feeling abnormal 22.54 10.66 255 98885 69531 42452664
Drug eruption 22.25 10.66 13 99127 23062 42499133
Painful ejaculation 22.21 10.66 10 99130 169 42522026
Neonatal behavioural syndrome 22.10 10.66 10 99130 171 42522024
Dyspnoea 22.03 10.66 825 98315 441796 42080399
Hyperglycaemia 22.00 10.66 46 99094 45813 42476382
Hepatotoxicity 21.80 10.66 16 99124 25151 42497044
Arthralgia 21.76 10.66 341 98799 204897 42317298
Haemoglobin decreased 21.75 10.66 200 98940 132271 42389924
Ejaculation failure 21.72 10.66 17 99123 824 42521371
Torsade de pointes 21.68 10.66 56 99084 8538 42513657
Bruxism 21.68 10.66 26 99114 2143 42520052
Apraxia 21.58 10.66 22 99118 1513 42520682
Neonatal pneumonia 21.51 10.66 9 99131 126 42522069
Gastrointestinal haemorrhage 21.50 10.66 136 99004 97590 42424605
Toxic encephalopathy 21.49 10.66 49 99091 6904 42515291
Inhibitory drug interaction 21.30 10.66 24 99116 1850 42520345
Colitis 21.28 10.66 48 99092 46524 42475671
Psychotic disorder 21.03 10.66 128 99012 29080 42493115
Prescribed overdose 20.95 10.66 72 99068 12855 42509340
Dementia with Lewy bodies 20.82 10.66 17 99123 876 42521319
Somatic symptom disorder 20.74 10.66 16 99124 759 42521436
Peripheral swelling 20.70 10.66 124 99016 90146 42432049
Dissociation 20.66 10.66 34 99106 3764 42518431
Hypokinesia 20.60 10.66 60 99080 9811 42512384
Tension 20.58 10.66 27 99113 2437 42519758
Alcohol use disorder 20.55 10.66 7 99133 53 42522142
Electrocardiogram QT interval abnormal 20.54 10.66 8 99132 92 42522103
Somnambulism 20.54 10.66 32 99108 3383 42518812
Depersonalisation/derealisation disorder 20.49 10.66 15 99125 657 42521538
Ejaculation disorder 20.43 10.66 18 99122 1030 42521165
Congenital hearing disorder 20.38 10.66 8 99132 94 42522101
Back pain 20.38 10.66 221 98919 141555 42380640
Anaphylactic shock 20.30 10.66 15 99125 23502 42498693
Frequent bowel movements 20.24 10.66 101 99039 21306 42500889
Neutropenic sepsis 20.17 10.66 6 99134 15940 42506255
Graft versus host disease 20.15 10.66 3 99137 12922 42509273
Depressed level of consciousness 20.15 10.66 185 98955 47785 42474410
Blood catecholamines increased 20.05 10.66 6 99134 28 42522167
Lower respiratory tract infection 20.05 10.66 41 99099 41165 42481030
Gastrointestinal hypermotility 20.04 10.66 9 99131 151 42522044
Rheumatoid arthritis 20.00 10.66 43 99097 42397 42479798
Physical assault 19.93 10.66 18 99122 1064 42521131
Electric shock sensation 19.83 10.66 13 99127 475 42521720
Burnout syndrome 19.83 10.66 9 99131 155 42522040
Asthma 19.81 10.66 227 98913 62087 42460108
Pneumonia bacterial 19.67 10.66 6 99134 15686 42506509
Suicidal behaviour 19.66 10.66 21 99119 1525 42520670
Judgement impaired 19.61 10.66 14 99126 589 42521606
Negative thoughts 19.52 10.66 15 99125 707 42521488
Hyperthermia 19.48 10.66 69 99071 12505 42509690
Hypertonia neonatal 19.47 10.66 14 99126 596 42521599
Obstructive airways disorder 19.44 10.66 111 99029 24648 42497547
Electroencephalogram abnormal 19.35 10.66 29 99111 2963 42519232
Appendicitis 19.33 10.66 12 99128 20601 42501594
Hepatic failure 19.32 10.66 37 99103 38063 42484132
Multiple drug therapy 19.28 10.66 18 99122 1111 42521084
Septum pellucidum agenesis 19.20 10.66 7 99133 66 42522129
Dermatitis atopic 19.16 10.66 68 99072 12336 42509859
Post-traumatic stress disorder 19.03 10.66 25 99115 2260 42519935
Depressive symptom 18.98 10.66 33 99107 3820 42518375
Anaphylactic reaction 18.77 10.66 45 99095 42698 42479497
Dementia 18.70 10.66 82 99058 16398 42505797
Crying 18.60 10.66 44 99096 6350 42515845
Hypotonia neonatal 18.59 10.66 20 99120 1464 42520731
Autoscopy 18.52 10.66 10 99130 254 42521941
Hepatic function abnormal 18.40 10.66 60 99080 51507 42470688
Feeling of despair 18.24 10.66 18 99122 1190 42521005
Dysgeusia 18.16 10.66 139 99001 34050 42488145
Brain stem haematoma 18.10 10.66 8 99132 129 42522066
Reactive psychosis 18.03 10.66 4 99136 3 42522192
Pulmonary embolism 18.01 10.66 384 98756 119228 42402967
Hypogammaglobulinaemia 18.00 10.66 3 99137 11888 42510307
Liver disorder 18.00 10.66 41 99099 39603 42482592
Talipes 17.90 10.66 24 99116 2212 42519983
Sleep-related eating disorder 17.83 10.66 11 99129 361 42521834
Affect lability 17.83 10.66 33 99107 4011 42518184
Posterior reversible encephalopathy syndrome 17.79 10.66 4 99136 12817 42509378
Trisomy 21 17.76 10.66 13 99127 569 42521626
Helplessness 17.70 10.66 7 99133 84 42522111
Periodic limb movement disorder 17.62 10.66 8 99132 138 42522057
Hypersomnia 17.56 10.66 74 99066 14544 42507651
Transplant rejection 17.39 10.66 5 99135 13583 42508612
Haemorrhage 17.38 10.66 77 99063 60486 42461709
Autoimmune disorder 17.38 10.66 25 99115 2462 42519733
Tremor neonatal 17.21 10.66 12 99128 486 42521709
Renal dysplasia 17.20 10.66 9 99131 214 42521981
Persistent depressive disorder 17.19 10.66 12 99128 487 42521708
Deprescribing error 17.14 10.66 5 99135 21 42522174
Bronchiectasis 17.02 10.66 85 99055 17934 42504261
Nephropathy toxic 16.94 10.66 9 99131 16829 42505366
Neurotoxicity 16.91 10.66 18 99122 23633 42498562
Hypospadias 16.86 10.66 30 99110 3537 42518658
Drug resistance 16.72 10.66 34 99106 34214 42487981
Electrocardiogram QT shortened 16.68 10.66 8 99132 157 42522038
Fluid retention 16.66 10.66 30 99110 31589 42490606
Muscle necrosis 16.58 10.66 16 99124 1029 42521166
Alcohol abuse 16.56 10.66 32 99108 4017 42518178
Flat affect 16.56 10.66 16 99124 1031 42521164
Nasopharyngitis 16.43 10.66 121 99019 83875 42438320
Priapism 16.42 10.66 42 99098 6365 42515830
Myocardial infarction 16.37 10.66 197 98943 123812 42398383
Toxicity to various agents 16.37 10.66 670 98470 228466 42293729
Ulcer 16.23 10.66 9 99131 16432 42505763
Pulmonary fibrosis 16.20 10.66 112 99028 26569 42495626
Inflammation 16.19 10.66 34 99106 33813 42488382
Contraindicated product administered 16.18 10.66 21 99119 25251 42496944
Acute myocardial infarction 16.07 10.66 75 99065 58090 42464105
Pelvic kidney 16.06 10.66 7 99133 109 42522086
Cerebral infarction 16.04 10.66 30 99110 31139 42491056
Muscle twitching 16.03 10.66 62 99078 11718 42510477
Exposure during pregnancy 16.00 10.66 50 99090 8498 42513697
Mood altered 15.91 10.66 58 99082 10660 42511535
Corneal reflex decreased 15.89 10.66 8 99132 175 42522020
Bladder cancer 15.88 10.66 10 99130 17037 42505158
Illness anxiety disorder 15.77 10.66 8 99132 178 42522017
Panic disorder 15.63 10.66 17 99123 1260 42520935
Hypoglycaemia neonatal 15.59 10.66 22 99118 2128 42520067
Hallucination, olfactory 15.59 10.66 9 99131 261 42521934
Drug hypersensitivity 15.48 10.66 152 98988 99237 42422958
Renal tubular necrosis 15.47 10.66 12 99128 18342 42503853
Atrial fibrillation 15.44 10.66 230 98910 139363 42382832
Premature ejaculation 15.35 10.66 7 99133 122 42522073
Product use issue 15.28 10.66 110 99030 76641 42445554
Obsessive thoughts 15.27 10.66 14 99126 844 42521351
Fear 15.16 10.66 58 99082 10907 42511288
Personality disorder 15.15 10.66 16 99124 1147 42521048
Pernicious anaemia 15.14 10.66 7 99133 126 42522069
Venous angioma of brain 15.14 10.66 5 99135 34 42522161
Pulmonary oedema 15.12 10.66 68 99072 53204 42468991
Obsessive-compulsive disorder 15.06 10.66 42 99098 6701 42515494
Pathogen resistance 15.05 10.66 4 99136 11446 42510749
End stage renal disease 15.03 10.66 10 99130 16548 42505647
Acquired haemophilia 15.00 10.66 19 99121 1656 42520539
Disinhibition 14.98 10.66 30 99110 3865 42518330
Neoplasm progression 14.84 10.66 28 99112 28972 42493223
Klebsiella infection 14.82 10.66 4 99136 11328 42510867
Dystonia 14.78 10.66 64 99076 12726 42509469
Lymphopenia 14.77 10.66 17 99123 21546 42500649
Abdominal distension 14.68 10.66 102 99038 71633 42450562
Family stress 14.66 10.66 7 99133 136 42522059
Ejaculation delayed 14.47 10.66 9 99131 300 42521895
Lung neoplasm malignant 14.34 10.66 14 99126 19133 42503062
Dysgraphia 14.25 10.66 23 99117 2505 42519690
Congenital hydronephrosis 14.17 10.66 13 99127 784 42521411
Anxiety disorder 14.11 10.66 20 99120 1943 42520252
Congenital pulmonary hypertension 14.09 10.66 6 99134 88 42522107
Feelings of worthlessness 14.08 10.66 9 99131 315 42521880
Opiates positive 14 10.66 11 99129 536 42521659
Enterocolitis 13.97 10.66 3 99137 9926 42512269
Neonatal hyponatraemia 13.97 10.66 6 99134 90 42522105
Pseudomonas infection 13.95 10.66 10 99130 15913 42506282
Behaviour disorder 13.89 10.66 42 99098 7012 42515183
Bacteraemia 13.88 10.66 23 99117 25017 42497178
Blood phosphorus increased 13.66 10.66 6 99134 12519 42509676
Retrograde amnesia 13.64 10.66 8 99132 239 42521956
Genital anaesthesia 13.49 10.66 4 99136 18 42522177
Myositis 13.47 10.66 9 99131 14857 42507338
Coronary artery disease 13.28 10.66 72 99068 53648 42468547
Hypertension 13.28 10.66 292 98848 166912 42355283
Second primary malignancy 13.26 10.66 3 99137 9572 42512623
Attention deficit hyperactivity disorder 13.25 10.66 25 99115 3083 42519112
Urinary incontinence 13.18 10.66 91 99049 21577 42500618
Personality change 13.15 10.66 36 99104 5683 42516512
Rapid eye movements sleep abnormal 13.14 10.66 7 99133 173 42522022
Delusional disorder, erotomanic type 13.13 10.66 3 99137 3 42522192
Gynaecomastia 13.11 10.66 61 99079 12506 42509689
Hyperkinesia 13.09 10.66 20 99120 2078 42520117
Cardiac discomfort 13.07 10.66 12 99128 725 42521470
Hyperphosphataemia 13.01 10.66 7 99133 12997 42509198
Lymphocele 13.00 10.66 17 99123 1530 42520665
Cytomegalovirus viraemia 12.95 10.66 4 99136 10373 42511822
Drug intolerance 12.94 10.66 122 99018 80302 42441893
Haemolytic anaemia 12.92 10.66 6 99134 12121 42510074
Breath sounds abnormal 12.86 10.66 6 99134 12087 42510108
Abnormal sleep-related event 12.86 10.66 10 99130 480 42521715
Oromandibular dystonia 12.85 10.66 11 99129 605 42521590
Headache 12.80 10.66 680 98460 238689 42283506
Acute myeloid leukaemia 12.75 10.66 20 99120 22236 42499959
Skin discolouration 12.72 10.66 18 99122 20872 42501323
Electrocardiogram abnormal 12.69 10.66 52 99088 10093 42512102
Herpes zoster 12.68 10.66 47 99093 38830 42483365
Social fear 12.67 10.66 3 99137 4 42522191
Angina pectoris 12.64 10.66 37 99103 32859 42489336
C-reactive protein abnormal 12.63 10.66 3 99137 9258 42512937
Coagulopathy 12.62 10.66 20 99120 22142 42500053
Pneumonitis 12.61 10.66 52 99088 41666 42480529
Logorrhoea 12.49 10.66 23 99117 2784 42519411
Loss of employment 12.42 10.66 10 99130 505 42521690
Chronic kidney disease 12.41 10.66 62 99078 47179 42475016
Male orgasmic disorder 12.32 10.66 6 99134 122 42522073
Hypocalcaemia 12.29 10.66 33 99107 30140 42492055
Hyponatraemia 12.27 10.66 316 98824 101146 42421049
Transient global amnesia 12.24 10.66 9 99131 397 42521798
Sperm concentration decreased 12.22 10.66 7 99133 200 42521995
False positive investigation result 12.15 10.66 11 99129 652 42521543
Eczema 12.13 10.66 127 99013 33959 42488236
Hypervolaemia 12.13 10.66 22 99118 23103 42499092
Rash 11.85 10.66 525 98615 276429 42245766
Lymphadenopathy 11.78 10.66 39 99101 33326 42488869
Grandiosity 11.74 10.66 8 99132 312 42521883
Stevens-Johnson syndrome 11.72 10.66 21 99119 22157 42500038
Epstein-Barr virus infection 11.68 10.66 4 99136 9714 42512481
Peripheral sensory neuropathy 11.64 10.66 3 99137 8759 42513436
Arthropathy 11.59 10.66 33 99107 29564 42492631
Leukocyte adhesion deficiency type I 11.55 10.66 4 99136 32 42522163
Bradypnoea 11.47 10.66 29 99111 4364 42517831
Eye inflammation 11.45 10.66 24 99116 3194 42519001
Polyneuropathy 11.44 10.66 16 99124 18645 42503550
Intensive care 11.42 10.66 14 99126 1180 42521015
Pulmonary toxicity 11.42 10.66 3 99137 8652 42513543
Chemical submission 11.35 10.66 5 99135 80 42522115
Swelling face 11.32 10.66 30 99110 27524 42494671
Selective eating disorder 11.27 10.66 17 99123 1747 42520448
Congenital megaureter 11.27 10.66 6 99134 148 42522047
Theft 11.23 10.66 7 99133 234 42521961
Immune effector cell-associated neurotoxicity syndrome 11.19 10.66 4 99136 9457 42512738
Rash maculo-papular 11.18 10.66 47 99093 37456 42484739
Flight of ideas 11.14 10.66 8 99132 340 42521855
Frustration tolerance decreased 11.11 10.66 24 99116 3262 42518933
Parasomnia 11.08 10.66 9 99131 460 42521735
Lip swelling 11.03 10.66 17 99123 19036 42503159
Epilepsy 11.02 10.66 101 99039 26070 42496125
Psychogenic seizure 10.98 10.66 9 99131 466 42521729
Synovitis 10.96 10.66 12 99128 15555 42506640
General physical health deterioration 10.92 10.66 268 98872 150978 42371217
Obsessive-compulsive personality disorder 10.91 10.66 6 99134 158 42522037
Renal haemorrhage 10.91 10.66 16 99124 1603 42520592
Febrile bone marrow aplasia 10.91 10.66 5 99135 10176 42512019
Device malfunction 10.84 10.66 57 99083 12270 42509925
Drug-induced liver injury 10.78 10.66 49 99091 38224 42483971
Sexually inappropriate behaviour 10.77 10.66 10 99130 613 42521582
Alcohol withdrawal syndrome 10.75 10.66 15 99125 1436 42520759
Congenital diaphragmatic hernia 10.75 10.66 7 99133 253 42521942
Weight increased 10.74 10.66 328 98812 107655 42414540
Cytopenia 10.73 10.66 15 99125 17482 42504713
Carbon dioxide increased 10.72 10.66 14 99126 1258 42520937
Productive cough 10.69 10.66 174 98966 51393 42470802
Generalised anxiety disorder 10.68 10.66 12 99128 922 42521273

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Suicide attempt 1130.22 9.80 1273 246425 102121 110239480
Completed suicide 1103.21 9.80 1960 245738 240421 110101180
Suicidal ideation 1006.97 9.80 1145 246553 92792 110248809
Serotonin syndrome 983.02 9.80 913 246785 58240 110283361
Intentional overdose 913.18 9.80 1296 246402 131205 110210396
Somnolence 609.63 9.80 1751 245947 295698 110045903
Electrocardiogram QT prolonged 559.17 9.80 930 246768 108030 110233571
Drug interaction 524.02 9.80 2363 245335 497820 109843781
Sopor 521.81 9.80 519 247179 36027 110305574
Pemphigus 457.90 9.80 4 247694 214566 110127035
Anxiety 441.09 9.80 1733 245965 343345 109998256
Hand deformity 437.12 9.80 11 247687 218495 110123106
Synovitis 426.86 9.80 55 247643 274037 110067564
Tremor 388.58 9.80 1164 246534 201068 110140533
Overdose 379.04 9.80 1269 246429 232525 110109076
Helicobacter infection 372.25 9.80 7 247691 181870 110159731
Duodenal ulcer perforation 363.04 9.80 7 247691 177693 110163908
Agitation 360.38 9.80 788 246910 112263 110229338
Glossodynia 351.86 9.80 42 247656 221962 110119639
Pericarditis 329.26 9.80 49 247649 219065 110122536
Folliculitis 325.94 9.80 11 247687 167642 110173959
Infusion related reaction 313.77 9.80 237 247461 380925 109960676
Intentional self-injury 305.97 9.80 398 247300 37031 110304570
Depression 298.56 9.80 1454 246244 315881 110025720
Contraindicated product administered 297.19 9.80 93 247605 248174 110093427
Joint swelling 295.21 9.80 334 247364 442511 109899090
Wound 287.53 9.80 84 247614 234353 110107248
Arthropathy 275.93 9.80 150 247548 287372 110054229
Muscle injury 274.56 9.80 9 247689 140798 110200803
Rheumatoid factor positive 273.82 9.80 4 247694 131636 110209965
Coma 265.79 9.80 719 246979 117150 110224451
Swelling 265.66 9.80 237 247461 350804 109990797
Hyponatraemia 263.29 9.80 1075 246623 216578 110125023
Lower respiratory tract infection 235.92 9.80 125 247573 242981 110098620
Inappropriate antidiuretic hormone secretion 228.36 9.80 328 247370 33523 110308078
Systemic lupus erythematosus 228.00 9.80 144 247554 254194 110087407
Toxicity to various agents 225.75 9.80 1843 245855 478712 109862889
Stomatitis 224.92 9.80 166 247532 270076 110071525
Withdrawal syndrome 218.96 9.80 309 247389 31071 110310530
Fall 216.03 9.80 2182 245516 601300 109740301
Treatment failure 209.90 9.80 187 247511 277047 110064554
Impaired healing 209.50 9.80 89 247609 196628 110144973
C-reactive protein abnormal 204.32 9.80 25 247673 129670 110211931
Mania 203.42 9.80 242 247456 20554 110321047
Fibromyalgia 200.99 9.80 66 247632 170843 110170758
Blister 199.34 9.80 132 247566 227244 110114357
Hepatic enzyme increased 195.81 9.80 259 247439 320633 110020968
Irritable bowel syndrome 193.84 9.80 63 247635 164152 110177449
Lip dry 189.60 9.80 8 247690 100075 110241526
Spirometry abnormal 188.74 9.80 130 247568 5367 110336234
Aggression 186.66 9.80 411 247287 58799 110282802
Product substitution issue 185.02 9.80 243 247455 22818 110318783
Irritability 183.71 9.80 360 247338 47449 110294152
Alopecia 182.02 9.80 337 247361 364416 109977185
Mobility decreased 181.10 9.80 159 247539 237263 110104338
Inflammation 179.32 9.80 105 247593 193133 110148468
Seizure 177.62 9.80 970 246728 220215 110121386
Bursitis 169.77 9.80 41 247657 129877 110211724
Conjunctivitis allergic 168.23 9.80 133 247565 6798 110334803
Akathisia 167.15 9.80 199 247499 16914 110324687
Mydriasis 166.31 9.80 226 247472 21931 110319670
Swollen tongue 165.98 9.80 397 247301 59965 110281636
Myelosuppression 164.96 9.80 12 247686 94328 110247273
Ill-defined disorder 163.78 9.80 73 247625 156780 110184821
Drug hypersensitivity 161.86 9.80 501 247197 453589 109888012
Mite allergy 157.53 9.80 119 247579 5684 110335917
Depressed mood 156.62 9.80 390 247308 60419 110281182
Psoriatic arthropathy 155.89 9.80 127 247571 196634 110144967
Reversible cerebral vasoconstriction syndrome 155.05 9.80 109 247589 4652 110336949
Dust allergy 153.98 9.80 119 247579 5882 110335719
Restlessness 153.60 9.80 369 247329 55890 110285711
Loss of consciousness 152.98 9.80 854 246844 195452 110146149
Joint range of motion decreased 152.39 9.80 42 247656 121790 110219811
Peripheral swelling 151.02 9.80 436 247262 403598 109938003
Electrocardiogram QRS complex prolonged 150.15 9.80 165 247533 12856 110328745
Febrile neutropenia 149.89 9.80 302 247396 316465 110025136
Muscle rigidity 149.29 9.80 224 247474 23807 110317794
Peripheral venous disease 149.11 9.80 10 247688 84107 110257494
Mycotic allergy 148.28 9.80 116 247582 5838 110335763
Infection 146.50 9.80 376 247322 361824 109979777
Dyskinesia 145.39 9.80 342 247356 51104 110290497
Panic attack 144.32 9.80 244 247454 28696 110312905
Torsade de pointes 136.62 9.80 208 247490 22392 110319209
C-reactive protein increased 134.82 9.80 174 247524 217745 110123856
Liver injury 133.60 9.80 86 247612 150327 110191274
Mental disorder 133.45 9.80 279 247419 38512 110303089
Disturbance in attention 132.57 9.80 371 247327 61624 110279977
Paranoia 132.54 9.80 204 247494 22170 110319431
Poisoning deliberate 131.30 9.80 222 247476 26109 110315492
Hyperreflexia 128.57 9.80 131 247567 9354 110332247
Drug intolerance 127.47 9.80 474 247224 406038 109935563
Hyperhidrosis 127.29 9.80 786 246912 186512 110155089
Rheumatoid arthritis 124.26 9.80 307 247391 299306 110042295
Psychomotor hyperactivity 121.69 9.80 186 247512 20091 110321510
Tardive dyskinesia 121.40 9.80 151 247547 13428 110328173
Drug withdrawal syndrome 118.64 9.80 263 247435 37791 110303810
Crying 117.24 9.80 208 247490 25420 110316181
Nightmare 112.71 9.80 261 247437 38602 110302999
Pulmonary vasculitis 112.29 9.80 103 247595 6457 110335144
Therapeutic product effect decreased 112.10 9.80 237 247461 244079 110097522
Sexual dysfunction 110.54 9.80 115 247583 8415 110333186
Wound infection 110.36 9.80 39 247659 96426 110245175
Type 2 diabetes mellitus 110.15 9.80 141 247557 177091 110164510
Apathy 109.01 9.80 157 247541 16082 110325519
Clonus 106.71 9.80 114 247584 8602 110332999
Pulmonary embolism 106.16 9.80 833 246865 213641 110127960
Neuroleptic malignant syndrome 103.49 9.80 233 247465 33826 110307775
Hypercholesterolaemia 103.45 9.80 37 247661 90800 110250801
Drug abuse 103.17 9.80 716 246982 176695 110164906
Product use issue 101.94 9.80 357 247341 311338 110030263
Vertigo 99.39 9.80 422 247276 86448 110255153
Suspected suicide 99.19 9.80 145 247553 15054 110326547
Vital capacity decreased 98.19 9.80 60 247638 2013 110339588
Maternal exposure during pregnancy 98.15 9.80 271 247427 254612 110086989
Normochromic normocytic anaemia 97.71 9.80 133 247565 12924 110328677
Hallucination 97.53 9.80 468 247230 100964 110240637
Galactorrhoea 97.15 9.80 78 247620 4077 110337524
Multiple organ dysfunction syndrome 97.09 9.80 118 247580 151592 110190009
Discomfort 97.05 9.80 210 247488 214497 110127104
Total lung capacity abnormal 96.60 9.80 81 247617 4502 110337099
Sympathomimetic effect 95.24 9.80 29 247669 152 110341449
Musculoskeletal stiffness 94.55 9.80 316 247382 279506 110062095
Anger 94.44 9.80 160 247538 18847 110322754
Abnormal dreams 93.86 9.80 129 247569 12651 110328950
Arthralgia 93.68 9.80 1208 246490 778424 109563177
Hallucination, auditory 93.31 9.80 192 247506 26205 110315396
Reversible airways obstruction 92.71 9.80 62 247636 2437 110339164
Anhedonia 90.45 9.80 140 247558 15288 110326313
Musculoskeletal pain 90.42 9.80 170 247528 182853 110158748
Obesity 89.96 9.80 73 247625 113278 110228323
Abnormal behaviour 88.80 9.80 239 247459 38800 110302801
Blood cholesterol increased 88.36 9.80 175 247523 184610 110156991
Burns second degree 87.45 9.80 97 247601 7636 110333965
Pyrexia 87.32 9.80 1451 246247 896814 109444787
Loss of libido 86.72 9.80 65 247633 3068 110338533
Delusion 86.59 9.80 175 247523 23580 110318021
Sinusitis 86.52 9.80 356 247342 296332 110045269
Catarrh 86.40 9.80 94 247604 7241 110334360
Neuritis 85.73 9.80 94 247604 7305 110334296
Nasopharyngitis 85.42 9.80 525 247173 393836 109947765
Complication of device insertion 85.04 9.80 102 247596 8736 110332865
Activation syndrome 84.92 9.80 32 247666 348 110341253
Pneumonia 83.97 9.80 1420 246278 875294 109466307
Major depression 83.78 9.80 111 247587 10510 110331091
Dermatitis atopic 83.57 9.80 180 247518 25361 110316240
Sciatica 83.18 9.80 52 247646 92347 110249254
Onychomadesis 82.20 9.80 5 247693 45658 110295943
Psychotic disorder 81.97 9.80 276 247422 50661 110290940
Neutropenia 81.50 9.80 498 247200 374122 109967479
Alcoholism 81.21 9.80 67 247631 3640 110337961
Intrusive thoughts 80.49 9.80 37 247661 684 110340917
Suicidal behaviour 80.39 9.80 65 247633 3432 110338169
Feeling abnormal 80.32 9.80 685 247013 180026 110161575
Hypertonia 79.23 9.80 96 247602 8310 110333291
Oedema 78.80 9.80 226 247472 209750 110131851
Extrapyramidal disorder 78.42 9.80 189 247509 28678 110312923
Lower limb fracture 77.18 9.80 36 247662 75312 110266289
Depressed level of consciousness 76.76 9.80 472 247226 111806 110229795
Osteoarthritis 76.56 9.80 186 247512 182437 110159164
Confusional state 76.09 9.80 1473 246225 467207 109874394
Adjustment disorder with depressed mood 75.53 9.80 6 247692 43877 110297724
Parosmia 75.04 9.80 118 247580 13062 110328539
Abdominal discomfort 74.93 9.80 545 247153 393313 109948288
Tinnitus 74.68 9.80 301 247397 60239 110281362
Septic shock 74.61 9.80 150 247548 157378 110184223
Multiple sclerosis relapse 74.56 9.80 265 247433 49975 110291626
Thrombocytopenia 74.22 9.80 467 247231 348418 109993183
Eosinophilic granulomatosis with polyangiitis 74.21 9.80 105 247593 10581 110331020
Homicidal ideation 74.18 9.80 63 247635 3564 110338037
Steroid dependence 73.83 9.80 93 247605 8376 110333225
Hypersomnia 73.33 9.80 181 247517 27880 110313721
General physical health deterioration 73.19 9.80 605 247093 424690 109916911
Bone erosion 72.87 9.80 9 247689 46362 110295239
Gastrointestinal disorder 72.63 9.80 287 247411 241665 110099936
Nail disorder 72.39 9.80 20 247678 57915 110283686
Alcohol poisoning 72.28 9.80 95 247603 8925 110332676
Hallucination, visual 72.24 9.80 224 247474 39381 110302220
Rapid eye movement sleep behaviour disorder 71.99 9.80 33 247665 606 110340995
Libido decreased 71.56 9.80 77 247621 5858 110335743
Long QT syndrome 71.54 9.80 84 247614 7034 110334567
Hypersensitivity 71.21 9.80 571 247127 403427 109938174
Gingival pain 71.06 9.80 127 247571 15609 110325992
Libido increased 71.00 9.80 53 247645 2486 110339115
Grip strength decreased 70.96 9.80 46 247652 80128 110261473
Off label use 70.90 9.80 2698 245000 1497487 108844114
Accidental overdose 70.67 9.80 266 247432 51568 110290033
Impaired quality of life 70.53 9.80 186 247512 29831 110311770
Psychomotor retardation 70.22 9.80 87 247611 7705 110333896
Deep vein thrombosis 69.02 9.80 543 247155 139344 110202257
Sepsis 68.69 9.80 440 247258 326906 110014695
Emotional distress 68.66 9.80 239 247459 44608 110296993
Impaired work ability 68.60 9.80 170 247528 26249 110315352
Sputum culture positive 68.40 9.80 62 247636 3827 110337774
Rash 68.14 9.80 1363 246335 819601 109522000
Sleep terror 68.10 9.80 79 247619 6531 110335070
Hypopnoea 66.34 9.80 103 247595 11277 110330324
Bruxism 65.92 9.80 68 247630 4926 110336675
Cytomegalovirus infection 65.81 9.80 20 247678 54424 110287177
Interstitial lung disease 65.71 9.80 133 247565 139201 110202400
Bradyphrenia 65.39 9.80 104 247594 11624 110329977
Myoclonus 65.23 9.80 192 247506 32806 110308795
Cerebral haematoma 64.47 9.80 93 247605 9539 110332062
Parkinsonism 64.32 9.80 149 247549 22038 110319563
Lupus-like syndrome 63.90 9.80 8 247690 40784 110300817
Alcohol use disorder 63.81 9.80 17 247681 49 110341552
Bronchial secretion retention 63.79 9.80 67 247631 4957 110336644
Syncope 63.63 9.80 714 246984 201822 110139779
Bipolar disorder 63.28 9.80 89 247609 8918 110332683
Gun shot wound 62.65 9.80 36 247662 1076 110340525
Derealisation 62.48 9.80 46 247652 2112 110339489
Foot deformity 61.96 9.80 16 247682 48464 110293137
Taste disorder 61.38 9.80 35 247663 65352 110276249
Catatonia 61.35 9.80 99 247599 11201 110330400
Full blood count abnormal 60.82 9.80 268 247430 55784 110285817
Insomnia 60.78 9.80 1140 246558 359450 109982151
Sinus bradycardia 60.64 9.80 174 247524 29309 110312292
Depressive symptom 60.40 9.80 84 247614 8330 110333271
Generalised tonic-clonic seizure 59.75 9.80 262 247436 54418 110287183
Liver disorder 58.73 9.80 146 247552 142097 110199504
Gastrointestinal procedural complication 58.70 9.80 26 247672 439 110341162
Cholecystitis chronic 58.22 9.80 88 247610 9412 110332189
Hip arthroplasty 58.20 9.80 26 247672 55787 110285814
Disorientation 58.05 9.80 312 247386 70359 110271242
Headache 57.57 9.80 2470 245228 879907 109461694
Abulia 57.12 9.80 36 247662 1277 110340324
Disease progression 57.00 9.80 317 247381 243717 110097884
Neurological symptom 56.91 9.80 115 247583 15493 110326108
Hypertension 56.22 9.80 804 246894 509280 109832321
Muscle twitching 56.17 9.80 171 247527 29764 110311837
Feeling of despair 56.17 9.80 55 247643 3743 110337858
Sedation 56.13 9.80 306 247392 69377 110272224
Autoimmune disorder 56.03 9.80 39 247659 65444 110276157
Finger deformity 55.65 9.80 5 247693 33087 110308514
Hostility 55.49 9.80 47 247651 2649 110338952
Drug screen positive 55.26 9.80 70 247628 6340 110335261
Knee arthroplasty 55.15 9.80 39 247659 64909 110276692
Urticaria 55.09 9.80 453 247245 318404 110023197
Resting tremor 55.07 9.80 39 247659 1684 110339917
Hypomania 54.82 9.80 89 247609 10121 110331480
Tachyphrenia 54.60 9.80 44 247654 2312 110339289
Antineutrophil cytoplasmic antibody positive 54.54 9.80 62 247636 5014 110336587
Alcohol use 54.18 9.80 56 247642 4066 110337535
Cardio-respiratory arrest 54.06 9.80 444 247254 115392 110226209
Palpitations 53.56 9.80 569 247129 158643 110182958
Blepharospasm 53.47 9.80 28 247670 54823 110286778
Sinus tachycardia 53.12 9.80 219 247479 44274 110297327
Osteoporosis 52.43 9.80 71 247627 87081 110254520
Red blood cell sedimentation rate increased 52.13 9.80 59 247639 78243 110263358
Head injury 51.56 9.80 212 247486 42805 110298796
Malignant neoplasm progression 51.15 9.80 209 247489 174358 110167243
Arteriosclerosis coronary artery 50.46 9.80 147 247551 24971 110316630
Device dislocation 50.31 9.80 171 247527 31533 110310068
Cardiac failure 49.89 9.80 233 247465 187393 110154208
Respiratory symptom 49.67 9.80 106 247592 14839 110326762
Wheezing 49.56 9.80 351 247347 254879 110086722
Multiple sclerosis 49.35 9.80 148 247550 25550 110316051
Dysgeusia 48.96 9.80 296 247402 69689 110271912
Tonsillar ulcer 48.94 9.80 23 247675 448 110341153
Adverse event 48.67 9.80 107 247591 108702 110232899
Product administered to patient of inappropriate age 48.62 9.80 74 247624 7962 110333639
Swelling face 47.54 9.80 362 247336 91959 110249642
Orthostatic hypotension 47.49 9.80 282 247416 65967 110275634
Rhinitis 47.29 9.80 134 247564 22411 110319190
Renal impairment 47.22 9.80 239 247459 188206 110153395
Hyperthermia 47.15 9.80 129 247569 21143 110320458
Capillaritis 47.11 9.80 41 247657 2398 110339203
Social avoidant behaviour 46.87 9.80 59 247639 5310 110336291
Coeliac disease 46.82 9.80 19 247679 43168 110298433
Tachycardia 46.64 9.80 740 246958 225905 110115696
Stress 46.61 9.80 399 247299 104949 110236652
Breast cancer stage II 46.40 9.80 4 247694 27371 110314230
Arteriosclerosis 46.02 9.80 141 247557 24626 110316975
Respiratory arrest 45.61 9.80 254 247444 58045 110283556
Exostosis 45.48 9.80 23 247675 45933 110295668
Mood swings 45.35 9.80 133 247565 22679 110318922
Negative thoughts 45.22 9.80 34 247664 1612 110339989
Anorgasmia 45.22 9.80 34 247664 1612 110339989
Cogwheel rigidity 44.62 9.80 48 247650 3650 110337951
Pneumocystis jirovecii pneumonia 44.42 9.80 20 247678 42715 110298886
Mental status changes 44.09 9.80 307 247391 75815 110265786
Bradycardia 43.84 9.80 537 247161 154980 110186621
Sleep talking 43.56 9.80 30 247668 1238 110340363
Forced expiratory volume decreased 43.27 9.80 93 247605 13083 110328518
Upper-airway cough syndrome 43.26 9.80 104 247594 15753 110325848
Self esteem decreased 43.06 9.80 28 247670 1049 110340552
Dizziness 42.94 9.80 1943 245755 696250 109645351
Night sweats 42.73 9.80 155 247543 133828 110207773
Persecutory delusion 42.48 9.80 61 247637 6230 110335371
Acute kidney injury 41.90 9.80 1093 246605 634337 109707264
Impulsive behaviour 41.72 9.80 44 247654 3271 110338330
Somnambulism 41.64 9.80 61 247637 6344 110335257
Drug-induced liver injury 41.62 9.80 134 247564 119933 110221668
Platelet count decreased 41.35 9.80 324 247374 230119 110111482
Middle insomnia 41.20 9.80 120 247578 20382 110321219
Alcohol abuse 41.19 9.80 53 247645 4876 110336725
Torticollis 40.98 9.80 43 247655 3178 110338423
Lethargy 40.66 9.80 353 247345 93223 110248378
Foreign body in reproductive tract 40.61 9.80 26 247672 948 110340653
Gestational diabetes 40.48 9.80 65 247633 7324 110334277
Live birth 40.40 9.80 58 247640 69426 110272175
Mucosal inflammation 40.22 9.80 98 247600 96043 110245558
Obstructive airways disorder 40.14 9.80 207 247491 45942 110295659
Restless legs syndrome 40.12 9.80 134 247564 24492 110317109
Screaming 40.03 9.80 52 247646 4829 110336772
Colitis microscopic 39.99 9.80 91 247607 13303 110328298
Emotional disorder 39.88 9.80 102 247596 16058 110325543
Poor quality sleep 39.87 9.80 146 247552 27931 110313670
Pancytopenia 39.84 9.80 290 247408 209323 110132278
Dysphonia 39.81 9.80 299 247399 75630 110265971
Drug tolerance decreased 39.46 9.80 7 247691 27533 110314068
Mental impairment 39.41 9.80 126 247572 22513 110319088
Bone marrow failure 39.15 9.80 43 247655 57805 110283796
Feeling jittery 38.51 9.80 95 247603 14627 110326974
Device expulsion 38.42 9.80 154 247544 30737 110310864
Bundle branch block right 38.37 9.80 85 247613 12206 110329395
Reduced facial expression 38.22 9.80 44 247654 3607 110337994
Dystonia 38.19 9.80 136 247562 25669 110315932
Bronchopulmonary aspergillosis 37.89 9.80 10 247688 29853 110311748
Aspergillus infection 37.83 9.80 6 247692 25610 110315991
Erectile dysfunction 37.67 9.80 109 247589 18447 110323154
Disseminated intravascular coagulation 37.48 9.80 23 247675 41263 110300338
Treatment noncompliance 37.47 9.80 286 247412 72704 110268897
Post-traumatic neck syndrome 37.30 9.80 37 247661 2558 110339043
Onychomycosis 37.07 9.80 20 247678 38511 110303090
Dissociative disorder 36.97 9.80 27 247671 1224 110340377
Hepatic function abnormal 36.59 9.80 92 247606 89203 110252398
Bradykinesia 36.41 9.80 77 247621 10711 110330890
Urinary retention 36.31 9.80 274 247424 69409 110272192
Intentional product use issue 35.95 9.80 368 247330 247538 110094063
Neutropenic sepsis 35.91 9.80 12 247686 30734 110310867
Gait inability 35.87 9.80 170 247528 136206 110205395
Fear 35.84 9.80 124 247574 23069 110318532
Respiratory disorder 35.50 9.80 66 247632 71316 110270285
Panic reaction 35.06 9.80 51 247647 5271 110336330
Loss of personal independence in daily activities 34.80 9.80 500 247198 149520 110192081
Nervousness 34.66 9.80 169 247529 36682 110304919
Conversion disorder 34.45 9.80 34 247664 2336 110339265
Ejaculation failure 34.42 9.80 17 247681 371 110341230
Sleep disorder due to a general medical condition 34.31 9.80 217 247481 51895 110289706
Antidepressant discontinuation syndrome 34.28 9.80 13 247685 144 110341457
Optic nerve injury 34.11 9.80 21 247677 714 110340887
Pulmonary alveolar haemorrhage 34.03 9.80 111 247587 20039 110321562
Adverse reaction 33.78 9.80 12 247686 29582 110312019
Orgasm abnormal 33.29 9.80 14 247684 207 110341394
Cytokine release syndrome 33.23 9.80 67 247631 70239 110271362
Multiple allergies 33.00 9.80 80 247618 12183 110329418
Thinking abnormal 32.75 9.80 91 247607 15049 110326552
Adjustment disorder with mixed anxiety and depressed mood 32.74 9.80 12 247686 120 110341481
Anticholinergic syndrome 32.64 9.80 44 247654 4236 110337365
Tension 32.49 9.80 48 247650 5030 110336571
Euphoric mood 32.14 9.80 65 247633 8762 110332839
Central pain syndrome 32.01 9.80 21 247677 799 110340802
Injury 31.90 9.80 249 247449 177016 110164585
Soft tissue injury 31.88 9.80 32 247666 2244 110339357
Feeling guilty 31.60 9.80 22 247676 924 110340677
Lung disorder 31.44 9.80 255 247443 179792 110161809
Liver function test increased 31.26 9.80 98 247600 88450 110253151
Legal problem 31.17 9.80 12 247686 139 110341462
Tumour lysis syndrome 31.11 9.80 15 247683 30786 110310815
Cardiac arrest 31.06 9.80 616 247082 196137 110145464
Anal incontinence 31.01 9.80 114 247584 21850 110319751
Nodule 30.95 9.80 150 247548 32481 110309120
Pain 30.93 9.80 1787 245911 953168 109388433
Self-injurious ideation 30.62 9.80 43 247655 4303 110337298
Hypokinesia 30.58 9.80 113 247585 21713 110319888
Laryngitis 30.42 9.80 30 247668 42381 110299220
Complication of device removal 30.04 9.80 44 247654 4576 110337025
Cognitive disorder 30.01 9.80 314 247384 87197 110254404
Transplant rejection 29.73 9.80 9 247689 24558 110317043
Chronic spontaneous urticaria 29.73 9.80 29 247669 1964 110339637
Blood creatinine increased 29.70 9.80 264 247434 182625 110158976
Suture rupture 29.65 9.80 19 247679 694 110340907
Rheumatoid nodule 29.43 9.80 5 247693 20291 110321310
Lower respiratory tract infection viral 29.41 9.80 25 247673 1416 110340185
Gambling disorder 29.22 9.80 30 247668 2161 110339440
Brain injury 29.15 9.80 81 247617 13395 110328206
Parkinsonian gait 29.14 9.80 22 247676 1050 110340551
Back injury 29.13 9.80 38 247660 47361 110294240
Erythema 29.11 9.80 468 247230 290979 110050622
Affective disorder 28.83 9.80 72 247626 11169 110330432
Angioedema 28.57 9.80 342 247356 98158 110243443
Joint stiffness 28.55 9.80 68 247630 67175 110274426
Obsessive-compulsive disorder 28.39 9.80 55 247643 7186 110334415
Lip ulceration 28.28 9.80 33 247665 2745 110338856
Postictal state 28.21 9.80 31 247667 2415 110339186
Device placement issue 28.16 9.80 27 247671 1790 110339811
Decreased interest 28.02 9.80 44 247654 4864 110336737
Yawning 27.87 9.80 25 247673 1522 110340079
Concussion 27.62 9.80 72 247626 11466 110330135
Withdrawal catatonia 27.58 9.80 15 247683 402 110341199
Bundle branch block left 27.42 9.80 77 247621 12811 110328790
Rhabdomyolysis 27.41 9.80 400 247298 120001 110221600
Myositis 27.33 9.80 18 247680 31098 110310503
Bradypnoea 27.21 9.80 60 247638 8589 110333012
Haematoma 27.20 9.80 224 247474 58252 110283349
Speech disorder 27.13 9.80 233 247465 61336 110280265
Oculogyric crisis 27.12 9.80 38 247660 3794 110337807
Patient elopement 27.06 9.80 14 247684 338 110341263
Drug dependence 26.80 9.80 198 247500 49822 110291779
Anaemia 26.74 9.80 979 246719 546107 109795494
Cytomegalovirus viraemia 26.60 9.80 4 247694 17760 110323841
Balance disorder 26.44 9.80 387 247311 116173 110225428
Intermenstrual bleeding 26.37 9.80 52 247646 6882 110334719
Poisoning 26.33 9.80 132 247566 28973 110312628
Thermohypoaesthesia 26.27 9.80 10 247688 112 110341489
Dysarthria 26.15 9.80 296 247402 83825 110257776
Cardiac murmur 26.14 9.80 117 247581 24511 110317090
Mood altered 26.14 9.80 106 247592 21269 110320332
Dry mouth 26.11 9.80 304 247394 199644 110141957
Psychiatric symptom 25.76 9.80 61 247637 9152 110332449
Morose 25.66 9.80 8 247690 46 110341555
Blood prolactin increased 25.65 9.80 41 247657 4601 110337000
Hypoaesthesia 25.58 9.80 523 247175 313700 110027901
Drug resistance 25.57 9.80 55 247643 56319 110285282
Miosis 25.30 9.80 107 247591 21876 110319725
Dissociation 25.20 9.80 63 247635 9779 110331822
Sleep-related eating disorder 25.18 9.80 19 247679 906 110340695
Disinhibition 25.10 9.80 33 247665 3101 110338500
Initial insomnia 25.04 9.80 65 247633 10324 110331277
Nausea 25.04 9.80 3146 244552 1232544 109109057
Haematotoxicity 25.02 9.80 8 247690 21074 110320527
Logorrhoea 24.99 9.80 42 247656 4915 110336686
Behaviour disorder 24.97 9.80 62 247636 9585 110332016
Pruritus 24.88 9.80 1057 246641 580503 109761098
Unresponsive to stimuli 24.83 9.80 235 247463 63555 110278046
Abdominal pain upper 24.72 9.80 594 247104 348517 109993084
Enterocolitis 24.71 9.80 6 247692 18943 110322658
Foetal exposure during pregnancy 24.67 9.80 53 247645 7452 110334149
Post transplant lymphoproliferative disorder 24.60 9.80 3 247695 15610 110325991
Amenorrhoea 24.60 9.80 60 247638 9171 110332430
Chest injury 24.42 9.80 34 247664 3375 110338226
Pulmonary toxicity 24.38 9.80 5 247693 17741 110323860
Skin ulcer 24.23 9.80 68 247630 63577 110278024
Chronic sinusitis 24.16 9.80 13 247685 25071 110316530
Platelet aggregation inhibition 24.14 9.80 11 247687 199 110341402
Slow speech 24.12 9.80 34 247664 3414 110338187
Immunodeficiency 24.01 9.80 31 247667 38807 110302794
Victim of sexual abuse 24.00 9.80 15 247683 524 110341077
Increased appetite 23.96 9.80 81 247617 14896 110326705
Dyspepsia 23.92 9.80 293 247405 190672 110150929
Angle closure glaucoma 23.73 9.80 34 247664 3465 110338136
Prescribed overdose 23.72 9.80 108 247590 87473 110254128
Painful ejaculation 23.71 9.80 9 247689 100 110341501
Haemoglobin urine 23.71 9.80 10 247688 149 110341452
Anaphylactic shock 23.62 9.80 50 247648 51496 110290105
Cytomegalovirus infection reactivation 23.53 9.80 6 247692 18327 110323274
Abortion spontaneous 23.34 9.80 144 247554 34138 110307463
Obsessive thoughts 23.31 9.80 21 247677 1286 110340315
Uterine perforation 23.29 9.80 49 247649 6791 110334810
Moaning 23.27 9.80 22 247676 1433 110340168
Maternal exposure timing unspecified 23.18 9.80 9 247689 21004 110320597
Heavy menstrual bleeding 23.15 9.80 85 247613 16280 110325321
Bipolar I disorder 23.04 9.80 27 247671 2256 110339345
Haemophagocytic lymphohistiocytosis 23.01 9.80 22 247676 31537 110310064
Rabbit syndrome 23.01 9.80 13 247685 376 110341225
Judgement impaired 22.99 9.80 21 247677 1309 110340292
Tearfulness 22.92 9.80 51 247647 7344 110334257
Ulcer haemorrhage 22.78 9.80 11 247687 22560 110319041
Sputum culture 22.75 9.80 12 247686 302 110341299
Band sensation 22.61 9.80 19 247679 1059 110340542
Nystagmus 22.54 9.80 67 247631 11510 110330091
Urinary incontinence 22.53 9.80 186 247512 48401 110293200
Infusion site reaction 22.28 9.80 6 247692 17676 110323925
Pathogen resistance 22.26 9.80 6 247692 17666 110323935
Contusion 22.22 9.80 378 247320 232983 110108618
Therapeutic response unexpected 22.18 9.80 109 247589 23734 110317867
Neutrophil count decreased 22.17 9.80 169 247529 120772 110220829
Sternal fracture 22.17 9.80 32 247666 3284 110338317
Anxiety disorder 21.89 9.80 40 247658 5000 110336601
Family stress 21.88 9.80 16 247682 727 110340874
Eczema 21.85 9.80 253 247445 72040 110269561
Compulsive shopping 21.81 9.80 17 247681 851 110340750
Hepatotoxicity 21.80 9.80 71 247627 63329 110278272
Altered state of consciousness 21.79 9.80 211 247487 57415 110284186
Biliary dyskinesia 21.77 9.80 27 247671 2394 110339207
Hot flush 21.73 9.80 235 247463 65801 110275800
Learning disorder 21.70 9.80 16 247682 736 110340865
Hypocoagulable state 21.67 9.80 28 247670 2587 110339014
Hallucinations, mixed 21.59 9.80 55 247643 8638 110332963
Eosinophil count increased 21.58 9.80 99 247599 20959 110320642
Illness anxiety disorder 21.51 9.80 11 247687 259 110341342
Toxic encephalopathy 21.51 9.80 79 247619 15135 110326466
Vision blurred 21.39 9.80 407 247291 128615 110212986
Electric shock sensation 21.32 9.80 24 247674 1920 110339681
Dysgraphia 21.28 9.80 38 247660 4667 110336934
Stiff person syndrome 21.24 9.80 15 247683 645 110340956
Muscle necrosis 21.11 9.80 23 247675 1774 110339827
Flat affect 21.03 9.80 27 247671 2478 110339123
Acute myeloid leukaemia 21.00 9.80 33 247665 38077 110303524
Electrocardiogram QT interval 20.95 9.80 11 247687 274 110341327
Metabolic function test abnormal 20.79 9.80 15 247683 667 110340934
Epstein-Barr virus infection 20.71 9.80 8 247690 18730 110322871
Electrocardiogram abnormal 20.71 9.80 90 247608 18619 110322982
Orbital swelling 20.68 9.80 8 247690 94 110341507
Renal failure 20.62 9.80 370 247328 226204 110115397
Hypermetropia 20.55 9.80 13 247685 464 110341137
Flight of ideas 20.54 9.80 16 247682 800 110340801
Blood creatine phosphokinase increased 20.44 9.80 252 247446 72825 110268776
Sight disability 20.43 9.80 10 247688 214 110341387
Joint dislocation 20.41 9.80 28 247670 34162 110307439
Hepatitis infectious mononucleosis 20.34 9.80 10 247688 216 110341385
Hyperdynamic left ventricle 20.32 9.80 14 247684 578 110341023
Dehydration 20.10 9.80 791 246907 278720 110062881
Sepsis neonatal 20.09 9.80 8 247690 102 110341499
Alcoholic hangover 20.05 9.80 5 247693 10 110341591
Pyramidal tract syndrome 20.01 9.80 16 247682 831 110340770
Presyncope 19.98 9.80 182 247516 48705 110292896
Immobilisation prolonged 19.90 9.80 9 247689 160 110341441
Sebaceous gland infection 19.90 9.80 9 247689 160 110341441
Thrombosis 19.84 9.80 348 247350 108314 110233287
Acetabulum fracture 19.79 9.80 17 247681 977 110340624
Bipolar II disorder 19.67 9.80 13 247685 501 110341100
Electroencephalogram abnormal 19.62 9.80 43 247655 6130 110335471
Product dose omission issue 19.61 9.80 895 246803 320887 110020714
Hyperventilation 19.57 9.80 54 247644 8893 110332708
Dysphoria 19.55 9.80 44 247654 6384 110335217
Polyarthritis 19.51 9.80 9 247689 18954 110322647
Painful respiration 19.22 9.80 32 247666 3715 110337886
Reflux gastritis 19.08 9.80 20 247678 1476 110340125
Nephropathy toxic 19.07 9.80 20 247678 27458 110314143
Product substitution error 19.01 9.80 7 247691 71 110341530
Abnormal clotting factor 18.98 9.80 9 247689 179 110341422
Intensive care 18.97 9.80 25 247673 2354 110339247
Male orgasmic disorder 18.75 9.80 7 247691 74 110341527
Coma scale abnormal 18.66 9.80 56 247642 9670 110331931
Creatinine renal clearance decreased 18.65 9.80 13 247685 21802 110319799
Barotrauma 18.54 9.80 9 247689 189 110341412
Neuropathy peripheral 18.52 9.80 286 247412 178991 110162610
Pulmonary fibrosis 18.51 9.80 143 247555 101899 110239702
Head banging 18.49 9.80 13 247685 555 110341046
Enuresis 18.42 9.80 33 247665 4063 110337538
Obsessive-compulsive personality disorder 18.39 9.80 8 247690 129 110341472
Constricted affect 18.38 9.80 5 247693 16 110341585
Dyspnoea 18.36 9.80 2185 245513 1104687 109236914
Endometrial disorder 18.36 9.80 14 247684 678 110340923
Thrombotic microangiopathy 18.30 9.80 23 247675 29126 110312475
Grandiosity 18.26 9.80 13 247685 566 110341035
Retroplacental haematoma 18.17 9.80 8 247690 133 110341468
Haemorrhagic stroke 18.16 9.80 70 247628 13719 110327882
Oedema peripheral 18.16 9.80 579 247119 328081 110013520
Arthritis 18.12 9.80 265 247433 167321 110174280
Caesarean section 18.09 9.80 70 247628 13747 110327854
Nephropathy 18.08 9.80 4 247694 13463 110328138
Acute myopia 18.03 9.80 9 247689 201 110341400
Hypophosphataemia 18.03 9.80 29 247669 33153 110308448
Inappropriate schedule of product administration 18.01 9.80 590 247108 203047 110138554
Angina pectoris 17.98 9.80 75 247623 62220 110279381
Hyperphagia 17.91 9.80 30 247668 3501 110338100
Palmar-plantar erythrodysaesthesia syndrome 17.81 9.80 41 247657 40984 110300617
Hyperprolactinaemia 17.80 9.80 43 247655 6532 110335069
Graft versus host disease 17.74 9.80 10 247688 18796 110322805
Rib fracture 17.71 9.80 133 247565 33637 110307964
Tongue biting 17.69 9.80 27 247671 2912 110338689
Vasculitis 17.54 9.80 139 247559 35734 110305867
Genital anaesthesia 17.52 9.80 5 247693 20 110341581
Rectal ulcer 17.49 9.80 25 247673 2542 110339059
Stoma obstruction 17.49 9.80 10 247688 296 110341305
Hepatic cirrhosis 17.37 9.80 85 247613 67541 110274060
Drug ineffective 17.35 9.80 3070 244628 1517470 108824131
Exposure via breast milk 17.32 9.80 16 247682 1012 110340589
Cerebral haemorrhage 17.30 9.80 222 247476 64746 110276855
Prescribed underdose 17.28 9.80 81 247617 65093 110276508
Kidney transplant rejection 17.28 9.80 3 247695 11984 110329617
Self-medication 17.14 9.80 41 247657 6191 110335410
Partner stress 17.13 9.80 10 247688 308 110341293
Intraventricular haemorrhage 17.09 9.80 38 247660 5469 110336132
Hyperglycaemia 17.00 9.80 116 247582 84974 110256627
Compulsions 16.99 9.80 11 247687 409 110341192
Large intestine anastomosis 16.92 9.80 7 247691 99 110341502
Cerebral thrombosis 16.92 9.80 24 247674 2424 110339177
Ascites 16.86 9.80 130 247568 92678 110248923
Red blood cell sedimentation rate abnormal 16.83 9.80 18 247680 24491 110317110
Pneumonia fungal 16.81 9.80 6 247692 14748 110326853
Hypervigilance 16.79 9.80 13 247685 644 110340957
Cytopenia 16.67 9.80 26 247672 30090 110311511
Trunk injury 16.62 9.80 5 247693 25 110341576
Subdural haematoma 16.61 9.80 139 247559 36315 110305286
Arrhythmia 16.57 9.80 233 247465 69342 110272259
Skin dystrophy 16.55 9.80 6 247692 58 110341543
Pustular psoriasis 16.44 9.80 5 247693 13600 110328001
Gangrene 16.44 9.80 8 247690 16333 110325268
Schizoaffective disorder 16.38 9.80 27 247671 3109 110338492
Drug withdrawal syndrome neonatal 16.38 9.80 10 247688 335 110341266
Acute myocardial infarction 16.35 9.80 115 247583 83662 110257939
Periodic limb movement disorder 16.17 9.80 11 247687 445 110341156
Neoplasm progression 16.13 9.80 82 247616 64513 110277088
Fluid replacement 16.12 9.80 15 247683 958 110340643
Ventricular dyskinesia 16.10 9.80 11 247687 448 110341153
Gallbladder disorder 16.04 9.80 91 247607 20938 110320663
Ovarian granulosa cell tumour 16.00 9.80 5 247693 29 110341572
Device related infection 15.97 9.80 41 247657 39478 110302123
Autonomic nervous system imbalance 15.87 9.80 38 247660 5742 110335859
Keratosis follicular 15.86 9.80 5 247693 30 110341571
Hypogammaglobulinaemia 15.84 9.80 13 247685 20063 110321538
Fluid retention 15.81 9.80 135 247563 94172 110247429
Bile acid malabsorption 15.78 9.80 11 247687 463 110341138
Belligerence 15.75 9.80 9 247689 266 110341335
Ulcer 15.73 9.80 47 247651 43069 110298532
Reactive psychosis 15.72 9.80 4 247694 9 110341592
Skin necrosis 15.68 9.80 15 247683 21497 110320104
Colitis 15.61 9.80 150 247548 102173 110239428
Muscle tightness 15.57 9.80 70 247628 14692 110326909
White blood cell count decreased 15.49 9.80 393 247305 228997 110112604
Product administration error 15.44 9.80 139 247559 37078 110304523
Myalgia 15.44 9.80 627 247071 221754 110119847
Appendicitis 15.35 9.80 25 247673 28439 110313162
Wrong product procured 15.31 9.80 3 247695 0 110341601
Anterograde amnesia 15.31 9.80 14 247684 874 110340727
Emotional poverty 15.27 9.80 15 247683 1025 110340576
Myocardial infarction 15.24 9.80 321 247377 191762 110149839
Imprisonment 15.15 9.80 13 247685 746 110340855
Product quality issue 15.14 9.80 106 247592 77193 110264408
Nephrotic syndrome 15.13 9.80 6 247692 13825 110327776
Carcinoid syndrome 15.11 9.80 9 247689 288 110341313
Chest pain 15.06 9.80 689 247009 375686 109965915
Death 15.05 9.80 1354 246344 697515 109644086
Blood phosphorus increased 14.98 9.80 9 247689 16331 110325270
Parasomnia 14.97 9.80 13 247685 758 110340843
Hypokalaemia 14.96 9.80 524 247174 181924 110159677
Dementia with Lewy bodies 14.95 9.80 15 247683 1051 110340550
Jaundice cholestatic 14.93 9.80 7 247691 14601 110327000
Pelvic pain 14.91 9.80 73 247625 15869 110325732
Bacteraemia 14.90 9.80 47 247651 42343 110299258
Dysmenorrhoea 14.87 9.80 28 247670 3582 110338019
Amyloid related imaging abnormality-oedema/effusion 14.86 9.80 18 247680 1557 110340044
Eosinophil count abnormal 14.86 9.80 15 247683 1059 110340542
Skin toxicity 14.85 9.80 4 247694 11779 110329822
Bacterial infection 14.84 9.80 53 247645 45983 110295618
Cardiac hypertrophy 14.82 9.80 20 247678 1927 110339674
Focal dyscognitive seizures 14.80 9.80 29 247669 3820 110337781
Retrograde amnesia 14.74 9.80 13 247685 774 110340827
Transient global amnesia 14.73 9.80 15 247683 1070 110340531
Metastases to lung 14.68 9.80 18 247680 23045 110318556
Opiates positive 14.64 9.80 14 247684 925 110340676
Apnoea 14.63 9.80 65 247633 13574 110328027
Aphasia 14.63 9.80 199 247499 58798 110282803
Proctitis 14.59 9.80 10 247688 16917 110324684
Posterior reversible encephalopathy syndrome 14.57 9.80 34 247664 33827 110307774
Impaired driving ability 14.49 9.80 39 247659 6331 110335270
Panic disorder 14.45 9.80 27 247671 3434 110338167
Pleural effusion 14.39 9.80 296 247402 177413 110164188
Blood catecholamines increased 14.31 9.80 6 247692 88 110341513
Respiratory failure 14.25 9.80 370 247328 214962 110126639
Peripheral sensory neuropathy 14.18 9.80 10 247688 16670 110324931
Persistent depressive disorder 14.13 9.80 17 247681 1460 110340141
Gynaecomastia 14.03 9.80 50 247648 9440 110332161
Dementia 14.02 9.80 120 247578 31553 110310048
Brain stem haematoma 14.00 9.80 7 247691 157 110341444
Ejection fraction decreased 13.90 9.80 46 247652 40834 110300767
Hypothyroidism 13.86 9.80 235 247463 72664 110268937
Gastrointestinal stoma output increased 13.85 9.80 14 247684 990 110340611
Neuromyelitis optica spectrum disorder 13.79 9.80 17 247681 1498 110340103
Inappropriate affect 13.78 9.80 18 247680 1681 110339920
Cerebellar syndrome 13.75 9.80 38 247660 6264 110335337
Ejaculation disorder 13.73 9.80 11 247687 573 110341028
Macular degeneration 13.69 9.80 17 247681 21642 110319959
Merycism 13.63 9.80 9 247689 346 110341255
Pseudomonas infection 13.63 9.80 26 247672 27827 110313774
Ear pain 13.61 9.80 67 247631 53159 110288442
Electrocardiogram QT interval abnormal 13.61 9.80 9 247689 347 110341254
Cyclic vomiting syndrome 13.61 9.80 7 247691 167 110341434
Blood alcohol increased 13.60 9.80 14 247684 1012 110340589
Drug screen false positive 13.50 9.80 16 247682 1353 110340248
Abdominal distension 13.49 9.80 294 247404 174809 110166792
Retching 13.44 9.80 92 247606 22590 110319011
End stage renal disease 13.42 9.80 17 247681 21456 110320145
Spinal cord oedema 13.41 9.80 10 247688 468 110341133
Laboratory test abnormal 13.39 9.80 52 247646 44027 110297574
Victim of crime 13.37 9.80 16 247682 1367 110340234
Condition aggravated 13.33 9.80 1859 245839 732977 109608624
Autism spectrum disorder 13.32 9.80 19 247679 1929 110339672
Pneumonia bacterial 13.31 9.80 24 247674 26237 110315364
Oromandibular dystonia 13.29 9.80 15 247683 1204 110340397
Distractibility 13.24 9.80 13 247685 888 110340713
Incoherent 13.19 9.80 45 247653 8313 110333288
Idiopathic orbital inflammation 13.19 9.80 9 247689 366 110341235
Attention-seeking behaviour 13.15 9.80 6 247692 109 110341492
False positive investigation result 13.08 9.80 16 247682 1398 110340203
Substance abuse 13.07 9.80 59 247639 12404 110329197
Joint hyperextension 13.06 9.80 9 247689 372 110341229
Inhibitory drug interaction 13.02 9.80 32 247666 4915 110336686
Breast swelling 13.02 9.80 17 247681 1587 110340014
Freezing phenomenon 13.01 9.80 22 247676 2587 110339014
Deprescribing error 12.98 9.80 5 247693 58 110341543
Muscular weakness 12.94 9.80 441 247257 248027 110093574
Diffuse large B-cell lymphoma 12.91 9.80 10 247688 15888 110325713
Negativism 12.90 9.80 13 247685 916 110340685
Adrenal insufficiency 12.89 9.80 50 247648 42340 110299261
Disorganised speech 12.84 9.80 25 247673 3278 110338323
Apraxia 12.81 9.80 26 247672 3514 110338087
Rhythm idioventricular 12.81 9.80 12 247686 773 110340828
Tonsillitis 12.77 9.80 44 247654 8169 110333432
Homicide 12.72 9.80 14 247684 1092 110340509
Eyelid haematoma 12.72 9.80 6 247692 118 110341483
Neurotoxicity 12.69 9.80 50 247648 42157 110299444
Mucormycosis 12.67 9.80 4 247694 10624 110330977
Polydipsia 12.67 9.80 42 247656 7646 110333955
Anaphylactic reaction 12.62 9.80 180 247518 114120 110227481
Oesophageal carcinoma 12.61 9.80 5 247693 11519 110330082
Haemoglobin decreased 12.60 9.80 443 247255 248284 110093317
Ejaculation delayed 12.59 9.80 7 247691 196 110341405
Leukopenia 12.59 9.80 246 247452 148545 110193056
Lactation disorder 12.59 9.80 8 247690 288 110341313
Medication error 12.55 9.80 317 247381 105049 110236552
Rash maculo-papular 12.55 9.80 106 247592 74116 110267485
Extradural haematoma 12.49 9.80 25 247673 3344 110338257
Internal fixation of fracture 12.45 9.80 10 247688 523 110341078
Hyperphosphataemia 12.44 9.80 11 247687 16370 110325231
Lymphocele 12.43 9.80 18 247680 1853 110339748
Wrong patient received product 12.40 9.80 38 247660 6636 110334965
Vaginitis gardnerella 12.33 9.80 5 247693 67 110341534
Ear infection 12.30 9.80 86 247612 62646 110278955
Left ventricle outflow tract obstruction 12.29 9.80 10 247688 533 110341068
Superior sagittal sinus thrombosis 12.25 9.80 14 247684 1139 110340462
Oral candidiasis 12.24 9.80 55 247643 44705 110296896
Blunted affect 12.24 9.80 10 247688 536 110341065
Genital hypoaesthesia 12.22 9.80 7 247691 208 110341393
Breath sounds abnormal 12.18 9.80 24 247674 25380 110316221
Movement disorder 12.18 9.80 130 247568 36274 110305327
Antipsychotic drug level increased 12.17 9.80 39 247659 6976 110334625
Status epilepticus 12.13 9.80 116 247582 31455 110310146
Corneal reflex decreased 12.13 9.80 10 247688 543 110341058
Anorectal disorder 12.12 9.80 22 247676 2737 110338864
Prothrombin level increased 12.09 9.80 10 247688 545 110341056
Upper respiratory tract infection 12.09 9.80 214 247484 131114 110210487
Anti-actin antibody positive 12.03 9.80 3 247695 6 110341595
Wound healing normal 12.03 9.80 3 247695 6 110341595
Electrocardiogram U wave present 11.98 9.80 6 247692 135 110341466
Drug dose omission by device 11.95 9.80 9 247689 14507 110327094
Stoma site discharge 11.91 9.80 22 247676 2773 110338828
Amyloid related imaging abnormality-microhaemorrhages and haemosiderin deposits 11.91 9.80 15 247683 1351 110340250
Cerebrovascular accident 11.87 9.80 508 247190 180776 110160825
Extensor plantar response 11.82 9.80 18 247680 1937 110339664
Laryngectomy 11.81 9.80 4 247694 31 110341570
Female orgasmic disorder 11.81 9.80 4 247694 31 110341570
Venoocclusive liver disease 11.81 9.80 10 247688 15197 110326404
Febrile bone marrow aplasia 11.80 9.80 13 247685 17452 110324149
Cardiac failure congestive 11.78 9.80 253 247445 150747 110190854
Attention deficit hyperactivity disorder 11.77 9.80 29 247669 4462 110337139
Bladder cancer 11.73 9.80 17 247681 20275 110321326
Cytotoxic oedema 11.73 9.80 9 247689 440 110341161
Convulsive threshold lowered 11.62 9.80 13 247685 1033 110340568
Basal cell carcinoma 11.57 9.80 57 247641 45213 110296388
Cholestasis 11.55 9.80 206 247492 64312 110277289
Ovarian vein thrombosis 11.53 9.80 5 247693 80 110341521
Cataract 11.51 9.80 118 247580 79367 110262234
Female genital tract fistula 11.49 9.80 12 247686 16507 110325094
Illusion 11.47 9.80 18 247680 1989 110339612
Device breakage 11.45 9.80 61 247637 13708 110327893
Hepatocellular injury 11.42 9.80 168 247530 50474 110291127
Staring 11.38 9.80 22 247676 2870 110338731
Menometrorrhagia 11.36 9.80 12 247686 894 110340707
Bone swelling 11.35 9.80 17 247681 1804 110339797
Arthritis bacterial 11.34 9.80 5 247693 10815 110330786
COVID-19 11.33 9.80 664 247034 244396 110097205
Sluggishness 11.30 9.80 40 247658 7527 110334074
Formication 11.29 9.80 33 247665 5615 110335986
Somatic symptom disorder 11.19 9.80 23 247675 3136 110338465
COVID-19 pneumonia 11.17 9.80 44 247654 37099 110304502
Economic problem 11.17 9.80 27 247671 4104 110337497
Psychomotor skills impaired 11.14 9.80 38 247660 7020 110334581
Dizziness postural 11.00 9.80 63 247635 14546 110327055
On and off phenomenon 11.00 9.80 28 247670 4396 110337205
Creatinine urine decreased 10.97 9.80 8 247690 362 110341239
Hepatitis 10.96 9.80 139 247559 89915 110251686
Cerebellar haematoma 10.94 9.80 10 247688 624 110340977
Gambling 10.93 9.80 8 247690 364 110341237
Postural orthostatic tachycardia syndrome 10.92 9.80 17 247681 1865 110339736
Erection increased 10.91 9.80 8 247690 365 110341236
Myelodysplastic syndrome 10.90 9.80 45 247653 37439 110304162
Glare 10.89 9.80 6 247692 165 110341436
Xerophthalmia 10.88 9.80 12 247686 939 110340662
Osteonecrosis of jaw 10.86 9.80 63 247635 47954 110293647
Arterial occlusive disease 10.78 9.80 11 247687 15297 110326304
Generalised anxiety disorder 10.76 9.80 21 247677 2758 110338843
Muscle spasms 10.76 9.80 511 247187 277646 110063955
Atrial flutter 10.73 9.80 24 247674 24238 110317363
Ecchymosis 10.68 9.80 71 247627 17267 110324334
Sickle cell anaemia with crisis 10.68 9.80 4 247694 9541 110332060
Uvulitis 10.66 9.80 4 247694 43 110341558
Adnexa uteri pain 10.57 9.80 8 247690 383 110341218
Drug-disease interaction 10.56 9.80 17 247681 1919 110339682
Priapism 10.55 9.80 33 247665 5828 110335773
Functional residual capacity increased 10.52 9.80 5 247693 100 110341501
Blood test abnormal 10.51 9.80 31 247667 28523 110313078
Temperature regulation disorder 10.50 9.80 8 247690 12818 110328783
Red blood cells urine 10.49 9.80 10 247688 658 110340943
Therapy non-responder 10.49 9.80 270 247428 157037 110184564
Burnout syndrome 10.48 9.80 8 247690 388 110341213
Blood pressure diastolic decreased 10.48 9.80 43 247655 35842 110305759
Cholecystectomy 10.47 9.80 50 247648 10759 110330842
External ear cellulitis 10.47 9.80 7 247691 275 110341326
Labelled drug-drug interaction medication error 10.45 9.80 106 247592 29196 110312405
Periorbital inflammation 10.45 9.80 7 247691 276 110341325
Hyponatraemic encephalopathy 10.45 9.80 8 247690 390 110341211
Amaurosis fugax 10.42 9.80 19 247679 2371 110339230
Female sexual dysfunction 10.42 9.80 4 247694 46 110341555
Klebsiella infection 10.40 9.80 18 247680 19991 110321610
Overweight 10.37 9.80 35 247663 6429 110335172
Hypernatraemia 10.37 9.80 72 247626 17761 110323840
Venous angioma of brain 10.34 9.80 4 247694 47 110341554
Lipohypertrophy 10.32 9.80 12 247686 994 110340607
Retinal ischaemia 10.31 9.80 12 247686 995 110340606
Sperm concentration decreased 10.30 9.80 5 247693 105 110341496
Language disorder 10.29 9.80 25 247673 3813 110337788
Disability 10.28 9.80 34 247664 30189 110311412
Pseudomonal bacteraemia 10.18 9.80 27 247671 4344 110337257
Gastric cancer 10.18 9.80 6 247692 11002 110330599
Hypochloraemia 10.16 9.80 24 247674 3594 110338007
Hepatitis chronic active 10.14 9.80 7 247691 290 110341311
Insulin C-peptide increased 10.13 9.80 6 247692 190 110341411
Tendon injury 10.09 9.80 19 247679 2430 110339171
Urinary tract infection staphylococcal 10.07 9.80 12 247686 1021 110340580
Investigation abnormal 10.05 9.80 19 247679 2437 110339164
Refusal of treatment by patient 10.00 9.80 45 247653 9449 110332152
Muscle haemorrhage 9.99 9.80 36 247662 6833 110334768
Psychotic disorder due to a general medical condition 9.95 9.80 7 247691 299 110341302
Enthesopathy 9.94 9.80 8 247690 12470 110329131
Neoplasm malignant 9.94 9.80 46 247652 37097 110304504
Maternal drugs affecting foetus 9.94 9.80 15 247683 1602 110339999
Hypertransaminasaemia 9.93 9.80 25 247673 24230 110317371
Hyperkinesia 9.92 9.80 22 247676 3162 110338439
Nuchal rigidity 9.91 9.80 13 247685 1219 110340382
Muscle contractions involuntary 9.90 9.80 27 247671 4417 110337184
Physical assault 9.86 9.80 15 247683 1613 110339988
Benign neoplasm of thyroid gland 9.83 9.80 12 247686 1047 110340554

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Human herpesvirus 6 infection 33.67 28.26 15 1149 45 112744
Trismus 29.92 28.26 20 1144 158 112631

Pharmacologic Action:

SourceCodeDescription
ATC N06AB10 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D017367 Selective Serotonin Reuptake Inhibitors
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018490 Serotonin Agents
MeSH PA D049990 Membrane Transport Modulators
FDA EPC N0000175696 Serotonin Reuptake Inhibitor
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:76779 EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
CHEBI has role CHEBI:53784 antispasmodic drug

Related Drugs by ATC class:

N06AB Selective serotonin reuptake inhibitors 7 drugs
citaloprametoperidonefluoxetinefluvoxamineparoxetinesertralinezimeldine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Major depressive disorder indication 370143000
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Obsessive-compulsive disorder off-label use 191736004 DOID:10933
Menopausal flushing off-label use 198436008
Panic disorder off-label use 371631005 DOID:594
Suicidal thoughts contraindication 6471006
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Upper gastrointestinal hemorrhage contraindication 37372002
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Heart disease contraindication 56265001 DOID:114
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Epilepsy contraindication 84757009 DOID:1826
Hyponatremia contraindication 89627008
Disease of liver contraindication 235856003 DOID:409
Serotonin syndrome contraindication 371089000
Myocardial infarction in recovery phase contraindication 418044006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 10MG BASE LEXAPRO ABBVIE N021323 Aug. 14, 2002 RX TABLET ORAL May 12, 2026 NEW PATIENT POPULATION
EQ 20MG BASE LEXAPRO ABBVIE N021323 Aug. 14, 2002 RX TABLET ORAL May 12, 2026 NEW PATIENT POPULATION
EQ 5MG BASE LEXAPRO ABBVIE N021323 Aug. 14, 2002 RX TABLET ORAL May 12, 2026 NEW PATIENT POPULATION
EQ 5MG BASE/5ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** LEXAPRO ABBVIE N021365 Nov. 27, 2002 DISCN SOLUTION ORAL May 12, 2026 NEW PATIENT POPULATION

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Ki 8.96 WOMBAT-PK CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 5.19 PDSP
5-hydroxytryptamine receptor 2C GPCR Ki 5.60 PDSP
5-hydroxytryptamine receptor 6 GPCR Ki 9 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 5.41 PDSP
Muscarinic acetylcholine receptor M1 GPCR Ki 5.91 PDSP
Histamine H1 receptor GPCR Ki 5.71 PDSP
Sodium-dependent serotonin transporter Transporter Ki 9.05 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 5.09 CHEMBL
Transporter Transporter Ki 4.98 CHEMBL

External reference:

IDSource
4024285 VUID
N0000022289 NUI
D02567 KEGG_DRUG
219861-08-2 SECONDARY_CAS_RN
4021356 VANDF
4024285 VANDF
C1099456 UMLSCUI
CHEBI:36791 CHEBI
CHEMBL1508 ChEMBL_ID
DB01175 DRUGBANK_ID
CHEMBL1200322 ChEMBL_ID
D000089983 MESH_DESCRIPTOR_UI
146570 PUBCHEM_CID
7177 IUPHAR_LIGAND_ID
7953 INN_ID
4O4S742ANY UNII
321988 RXNORM
158618 MMSL
16927 MMSL
187848 MMSL
32075 MMSL
d04812 MMSL
009709 NDDF
009710 NDDF
395246009 SNOMEDCT_US
400447003 SNOMEDCT_US
412384000 SNOMEDCT_US
68P PDB_CHEM_ID
4O4S742ANY INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2005 TABLET, FILM COATED 5 mg ORAL NDA 34 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2010 TABLET, FILM COATED 10 mg ORAL NDA 34 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2020 TABLET, FILM COATED 20 mg ORAL NDA 34 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2101 SOLUTION 5 mg ORAL NDA 34 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8475 TABLET, FILM COATED 5 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8476 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8477 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0904-6426 TABLET, FILM COATED 10 mg ORAL ANDA 30 sections
escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0904-6427 TABLET, FILM COATED 20 mg ORAL ANDA 30 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 10544-224 TABLET 5 mg ORAL ANDA 29 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 10544-225 TABLET 10 mg ORAL ANDA 29 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 10544-230 TABLET 20 mg ORAL ANDA 29 sections
Escitalopram Oxalate HUMAN PRESCRIPTION DRUG LABEL 1 10544-968 TABLET, FILM COATED 10 mg ORAL NDA authorized generic 32 sections
Escitalopram Oxalate HUMAN PRESCRIPTION DRUG LABEL 1 10544-969 TABLET, FILM COATED 20 mg ORAL NDA authorized generic 32 sections
escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 13668-135 TABLET, FILM COATED 5 mg ORAL ANDA 30 sections
escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 13668-136 TABLET, FILM COATED 10 mg ORAL ANDA 30 sections
escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 13668-137 TABLET, FILM COATED 20 mg ORAL ANDA 30 sections
escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 16571-755 TABLET, FILM COATED 5 mg ORAL ANDA 22 sections
escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 16571-756 TABLET, FILM COATED 10 mg ORAL ANDA 22 sections
escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 16571-757 TABLET, FILM COATED 20 mg ORAL ANDA 22 sections
Escitalopram Oxalate Human Prescription Drug Label 1 16571-769 SOLUTION 5 mg ORAL ANDA 30 sections
LEXAPRO HUMAN PRESCRIPTION DRUG LABEL 1 16590-139 TABLET, FILM COATED 10 mg ORAL NDA 31 sections
LEXAPRO HUMAN PRESCRIPTION DRUG LABEL 1 16590-833 TABLET, FILM COATED 5 mg ORAL NDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 16729-168 TABLET, FILM COATED 5 mg ORAL ANDA 33 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 16729-168 TABLET, FILM COATED 5 mg ORAL ANDA 33 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 16729-169 TABLET, FILM COATED 10 mg ORAL ANDA 33 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 16729-169 TABLET, FILM COATED 10 mg ORAL ANDA 33 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 16729-170 TABLET, FILM COATED 20 mg ORAL ANDA 33 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 16729-170 TABLET, FILM COATED 20 mg ORAL ANDA 33 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 21695-725 TABLET, FILM COATED 20 mg ORAL ANDA 30 sections